Mitch Report

date generated: 2022-10-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                         x
## 0610009B22Rik -0.23492611
## 0610009E02Rik -0.09139988
## 0610009L18Rik -1.43010001
## 0610010K14Rik -0.78295210
## 0610012G03Rik -0.10566247
## 0610030E20Rik -0.39636314

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	1604
num_genes_in_profile	17319
duplicated_genes_present	0
num_profile_genes_in_sets	8454
num_profile_genes_not_in_sets	8865

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	1604
num_genesets_excluded	423
num_genesets_included	1181

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
EUKARYOTIC TRANSLATION ELONGATION	88	5.90e-27	-0.662	3.48e-24
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	96	1.03e-27	-0.644	1.21e-24
SCAVENGING OF HEME FROM PLASMA	12	2.04e-04	0.619	4.38e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	107	1.56e-26	-0.596	6.15e-24
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	3.33e-04	0.575	6.66e-03
ATTENUATION PHASE	25	1.25e-06	-0.560	4.63e-05
NONSENSE MEDIATED DECAY NMD	110	4.85e-24	-0.558	1.15e-21
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	1.58e-03	0.550	2.19e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	4.37e-04	0.524	8.20e-03
SELENOAMINO ACID METABOLISM	110	1.46e-20	-0.513	2.46e-18
EUKARYOTIC TRANSLATION INITIATION	115	1.57e-19	-0.488	2.06e-17
SEROTONIN RECEPTORS	10	8.62e-03	0.480	7.14e-02
ASPARTATE AND ASPARAGINE METABOLISM	11	6.19e-03	0.477	5.75e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	3.16e-03	-0.473	3.52e-02
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	4.10e-03	0.460	4.29e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	1.07e-02	0.444	7.86e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS	165	1.14e-22	-0.442	2.25e-20
BRANCHED CHAIN AMINO ACID CATABOLISM	21	4.80e-04	0.440	8.73e-03
FGFR2 ALTERNATIVE SPLICING	25	1.65e-04	-0.435	3.67e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	2.60e-03	0.435	3.08e-02
REDUCTION OF CYTOSOLIC CA LEVELS	11	1.32e-02	0.432	8.85e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	9.65e-03	0.431	7.60e-02
RHOBTB2 GTPASE CYCLE	23	3.81e-04	-0.428	7.38e-03
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	4.57e-03	-0.423	4.62e-02
CITRIC ACID CYCLE TCA CYCLE	22	7.19e-04	0.417	1.16e-02
INFLUENZA INFECTION	146	1.05e-17	-0.411	1.24e-15
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	2.54e-02	-0.408	1.34e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	21	1.21e-03	0.408	1.79e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	2.59e-02	0.407	1.34e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	1.15e-02	0.405	8.14e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	1.04e-07	-0.400	5.36e-06
HSF1 ACTIVATION	27	3.54e-04	-0.397	6.96e-03
GLYCOSPHINGOLIPID METABOLISM	37	3.18e-05	0.395	8.16e-04
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	8.15e-03	0.395	6.87e-02
COMPLEX I BIOGENESIS	56	4.45e-07	-0.390	1.94e-05
RHOBTB3 ATPASE CYCLE	10	3.37e-02	0.388	1.49e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	1.57e-02	0.387	9.89e-02
BETA CATENIN PHOSPHORYLATION CASCADE	16	7.51e-03	0.386	6.52e-02
G PROTEIN ACTIVATION	23	1.39e-03	-0.385	2.02e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	3.51e-02	0.385	1.53e-01
FCGR ACTIVATION	11	2.84e-02	0.382	1.37e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	1.37e-07	-0.378	6.72e-06
GLUTAMATE AND GLUTAMINE METABOLISM	13	1.88e-02	0.376	1.08e-01
RRNA PROCESSING	195	1.40e-19	-0.376	2.06e-17
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	1.36e-02	0.368	8.92e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	14	1.86e-02	-0.363	1.08e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	18	7.81e-03	-0.362	6.63e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	10	4.96e-02	0.359	1.84e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	4.15e-02	-0.355	1.66e-01
DISEASES OF DNA REPAIR	11	4.31e-02	-0.352	1.70e-01

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
EUKARYOTIC TRANSLATION ELONGATION	88	5.90e-27	-0.662000	3.48e-24
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	96	1.03e-27	-0.644000	1.21e-24
SCAVENGING OF HEME FROM PLASMA	12	2.04e-04	0.619000	4.38e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	107	1.56e-26	-0.596000	6.15e-24
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	3.33e-04	0.575000	6.66e-03
ATTENUATION PHASE	25	1.25e-06	-0.560000	4.63e-05
NONSENSE MEDIATED DECAY NMD	110	4.85e-24	-0.558000	1.15e-21
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	1.58e-03	0.550000	2.19e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	4.37e-04	0.524000	8.20e-03
SELENOAMINO ACID METABOLISM	110	1.46e-20	-0.513000	2.46e-18
EUKARYOTIC TRANSLATION INITIATION	115	1.57e-19	-0.488000	2.06e-17
SEROTONIN RECEPTORS	10	8.62e-03	0.480000	7.14e-02
ASPARTATE AND ASPARAGINE METABOLISM	11	6.19e-03	0.477000	5.75e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	3.16e-03	-0.473000	3.52e-02
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	4.10e-03	0.460000	4.29e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	1.07e-02	0.444000	7.86e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS	165	1.14e-22	-0.442000	2.25e-20
BRANCHED CHAIN AMINO ACID CATABOLISM	21	4.80e-04	0.440000	8.73e-03
FGFR2 ALTERNATIVE SPLICING	25	1.65e-04	-0.435000	3.67e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	2.60e-03	0.435000	3.08e-02
REDUCTION OF CYTOSOLIC CA LEVELS	11	1.32e-02	0.432000	8.85e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	9.65e-03	0.431000	7.60e-02
RHOBTB2 GTPASE CYCLE	23	3.81e-04	-0.428000	7.38e-03
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	4.57e-03	-0.423000	4.62e-02
CITRIC ACID CYCLE TCA CYCLE	22	7.19e-04	0.417000	1.16e-02
INFLUENZA INFECTION	146	1.05e-17	-0.411000	1.24e-15
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	2.54e-02	-0.408000	1.34e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	21	1.21e-03	0.408000	1.79e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	2.59e-02	0.407000	1.34e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	1.15e-02	0.405000	8.14e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	1.04e-07	-0.400000	5.36e-06
HSF1 ACTIVATION	27	3.54e-04	-0.397000	6.96e-03
GLYCOSPHINGOLIPID METABOLISM	37	3.18e-05	0.395000	8.16e-04
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	8.15e-03	0.395000	6.87e-02
COMPLEX I BIOGENESIS	56	4.45e-07	-0.390000	1.94e-05
RHOBTB3 ATPASE CYCLE	10	3.37e-02	0.388000	1.49e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	1.57e-02	0.387000	9.89e-02
BETA CATENIN PHOSPHORYLATION CASCADE	16	7.51e-03	0.386000	6.52e-02
G PROTEIN ACTIVATION	23	1.39e-03	-0.385000	2.02e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	3.51e-02	0.385000	1.53e-01
FCGR ACTIVATION	11	2.84e-02	0.382000	1.37e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	1.37e-07	-0.378000	6.72e-06
GLUTAMATE AND GLUTAMINE METABOLISM	13	1.88e-02	0.376000	1.08e-01
RRNA PROCESSING	195	1.40e-19	-0.376000	2.06e-17
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	1.36e-02	0.368000	8.92e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	14	1.86e-02	-0.363000	1.08e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	18	7.81e-03	-0.362000	6.63e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	10	4.96e-02	0.359000	1.84e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	4.15e-02	-0.355000	1.66e-01
DISEASES OF DNA REPAIR	11	4.31e-02	-0.352000	1.70e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	3.01e-02	-0.347000	1.41e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	4.85e-02	0.344000	1.81e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	4.04e-02	0.342000	1.65e-01
MRNA SPLICING MINOR PATHWAY	52	2.09e-05	-0.341000	6.32e-04
CELLULAR RESPONSE TO STARVATION	147	1.02e-12	-0.341000	8.60e-11
SCAVENGING BY CLASS A RECEPTORS	14	2.83e-02	-0.339000	1.37e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	3.49e-02	-0.338000	1.53e-01
SIGNALING BY ROBO RECEPTORS	210	4.02e-17	-0.337000	4.32e-15
PROLONGED ERK ACTIVATION EVENTS	14	2.92e-02	0.337000	1.38e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	3.61e-02	-0.336000	1.55e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	3.09e-03	-0.335000	3.48e-02
ERKS ARE INACTIVATED	13	3.73e-02	0.334000	1.57e-01
BIOTIN TRANSPORT AND METABOLISM	11	5.61e-02	0.333000	1.94e-01
NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS	10	6.90e-02	0.332000	2.23e-01
MATURATION OF NUCLEOPROTEIN	10	6.97e-02	-0.331000	2.24e-01
OLFACTORY SIGNALING PATHWAY	30	1.71e-03	-0.331000	2.32e-02
VITAMIN B5 PANTOTHENATE METABOLISM	15	2.71e-02	0.330000	1.36e-01
REVERSIBLE HYDRATION OF CARBON DIOXIDE	10	7.29e-02	0.327000	2.30e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	36	7.05e-04	-0.326000	1.16e-02
ERK MAPK TARGETS	22	8.65e-03	0.323000	7.14e-02
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	5.87e-05	0.322000	1.45e-03
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	4.44e-02	-0.322000	1.72e-01
HSF1 DEPENDENT TRANSACTIVATION	35	1.02e-03	-0.321000	1.57e-02
MRNA SPLICING	188	4.05e-14	-0.320000	3.68e-12
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	5.66e-03	0.320000	5.44e-02
RECEPTOR MEDIATED MITOPHAGY	11	6.71e-02	0.319000	2.19e-01
SIGNALING BY WNT IN CANCER	31	2.14e-03	0.319000	2.69e-02
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	8.15e-02	-0.318000	2.50e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	1.45e-02	0.316000	9.28e-02
SIGNALING BY EGFR IN CANCER	22	1.05e-02	-0.315000	7.84e-02
SYNTHESIS OF PC	27	4.66e-03	0.315000	4.66e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	6.20e-02	0.311000	2.07e-01
UNWINDING OF DNA	12	6.20e-02	0.311000	2.07e-01
DAG AND IP3 SIGNALING	40	6.68e-04	0.311000	1.13e-02
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	29	3.81e-03	0.310000	4.05e-02
EFFECTS OF PIP2 HYDROLYSIS	27	5.31e-03	0.310000	5.24e-02
NRAGE SIGNALS DEATH THROUGH JNK	56	6.06e-05	0.310000	1.46e-03
INOSITOL PHOSPHATE METABOLISM	46	2.77e-04	0.310000	5.75e-03
HEME BIOSYNTHESIS	13	5.72e-02	0.305000	1.97e-01
INTRA GOLGI TRAFFIC	43	5.75e-04	0.304000	1.03e-02
APOPTOSIS INDUCED DNA FRAGMENTATION	10	9.76e-02	0.303000	2.81e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	2.66e-02	0.302000	1.36e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	24	1.05e-02	-0.302000	7.84e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	5.10e-02	0.301000	1.88e-01
INTERFERON ALPHA BETA SIGNALING	57	8.57e-05	-0.301000	2.02e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS	14	5.15e-02	0.301000	1.88e-01
PLATELET CALCIUM HOMEOSTASIS	25	9.47e-03	0.300000	7.56e-02
HDMS DEMETHYLATE HISTONES	26	8.74e-03	0.297000	7.17e-02
RETROGRADE NEUROTROPHIN SIGNALLING	14	5.56e-02	0.296000	1.94e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	1.09e-01	0.292000	3.03e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	2.45e-02	0.291000	1.33e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	2.89e-02	-0.290000	1.38e-01
NICOTINAMIDE SALVAGING	15	5.27e-02	-0.289000	1.90e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	13	7.19e-02	0.288000	2.28e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	29	7.47e-03	0.287000	6.52e-02
RESPIRATORY ELECTRON TRANSPORT	102	6.21e-07	-0.286000	2.53e-05
SPHINGOLIPID METABOLISM	78	1.29e-05	0.286000	4.02e-04
INHIBITION OF DNA RECOMBINATION AT TELOMERE	34	3.97e-03	-0.286000	4.18e-02
TRANSLATION	287	9.18e-17	-0.285000	9.03e-15
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	1.18e-02	-0.285000	8.29e-02
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	2.37e-02	0.285000	1.29e-01
RRNA PROCESSING IN THE MITOCHONDRION	10	1.19e-01	0.284000	3.21e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	4.94e-02	0.284000	1.84e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	17	4.37e-02	-0.283000	1.71e-01
DARPP 32 EVENTS	23	1.94e-02	0.282000	1.11e-01
CA DEPENDENT EVENTS	36	3.58e-03	0.281000	3.88e-02
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	12	9.33e-02	0.280000	2.72e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	87	6.58e-06	0.280000	2.22e-04
CD28 DEPENDENT PI3K AKT SIGNALING	21	2.70e-02	0.279000	1.36e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	2.73e-02	0.278000	1.36e-01
VXPX CARGO TARGETING TO CILIUM	19	3.59e-02	0.278000	1.55e-01
PRE NOTCH PROCESSING IN GOLGI	17	4.73e-02	0.278000	1.78e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	9.63e-02	0.277000	2.79e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	5.53e-02	0.277000	1.94e-01
DNA METHYLATION	19	3.75e-02	-0.276000	1.57e-01
VOLTAGE GATED POTASSIUM CHANNELS	39	3.00e-03	0.275000	3.48e-02
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	3.36e-02	0.275000	1.49e-01
P75NTR REGULATES AXONOGENESIS	10	1.34e-01	0.274000	3.48e-01
PI METABOLISM	80	2.38e-05	0.273000	6.72e-04
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	10	1.35e-01	0.273000	3.48e-01
MYOGENESIS	24	2.14e-02	0.271000	1.20e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	23	2.49e-02	-0.270000	1.33e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	9.18e-04	0.268000	1.45e-02
SIGNALING BY FGFR2 IIIA TM	19	4.38e-02	-0.267000	1.71e-01
GLUCONEOGENESIS	27	1.64e-02	0.267000	1.01e-01
GLUCAGON TYPE LIGAND RECEPTORS	26	1.86e-02	-0.267000	1.08e-01
SODIUM CALCIUM EXCHANGERS	10	1.46e-01	0.265000	3.64e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	4.74e-02	0.263000	1.78e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	1.32e-01	0.262000	3.43e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	1.33e-01	-0.261000	3.46e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	5.35e-12	-0.260000	3.71e-10
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	3.08e-02	-0.260000	1.43e-01
ION TRANSPORT BY P TYPE ATPASES	48	1.88e-03	0.259000	2.41e-02
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	4.48e-02	0.259000	1.72e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	4.00e-02	0.259000	1.64e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	5.86e-07	-0.259000	2.47e-05
INTERLEUKIN 6 FAMILY SIGNALING	19	5.16e-02	0.258000	1.88e-01
IRAK4 DEFICIENCY TLR2 4	13	1.08e-01	0.258000	2.99e-01
PRC2 METHYLATES HISTONES AND DNA	28	1.85e-02	-0.257000	1.08e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	2.10e-02	0.257000	1.19e-01
LONG TERM POTENTIATION	23	3.35e-02	0.256000	1.49e-01
EARLY PHASE OF HIV LIFE CYCLE	13	1.10e-01	-0.256000	3.04e-01
FATTY ACYL COA BIOSYNTHESIS	32	1.26e-02	0.255000	8.64e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	2.48e-02	0.254000	1.33e-01
SHC MEDIATED CASCADE FGFR3	12	1.27e-01	0.254000	3.37e-01
RAP1 SIGNALLING	15	8.87e-02	0.254000	2.63e-01
MITOCHONDRIAL TRANSLATION	93	2.39e-05	-0.254000	6.72e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	6.26e-02	-0.254000	2.08e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	27	2.32e-02	0.253000	1.27e-01
HIV ELONGATION ARREST AND RECOVERY	32	1.37e-02	-0.252000	8.96e-02
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	1.03e-01	0.251000	2.93e-01
G PROTEIN MEDIATED EVENTS	52	1.81e-03	0.250000	2.40e-02
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	1.08e-01	-0.248000	2.99e-01
TIGHT JUNCTION INTERACTIONS	18	6.84e-02	0.248000	2.22e-01
STRIATED MUSCLE CONTRACTION	26	2.86e-02	-0.248000	1.37e-01
KERATAN SULFATE BIOSYNTHESIS	26	2.95e-02	0.247000	1.39e-01
MTOR SIGNALLING	41	6.35e-03	0.246000	5.86e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	6.33e-02	-0.246000	2.09e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	1.80e-03	-0.246000	2.40e-02
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	21	5.16e-02	-0.245000	1.88e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	4.17e-02	-0.245000	1.66e-01
SIALIC ACID METABOLISM	32	1.64e-02	0.245000	1.01e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	24	3.84e-02	0.244000	1.60e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	32	1.69e-02	0.244000	1.03e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	2.60e-02	0.243000	1.34e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	26	3.20e-02	0.243000	1.47e-01
PARASITE INFECTION	57	1.53e-03	0.243000	2.17e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS	21	5.52e-02	-0.242000	1.94e-01
RAF ACTIVATION	34	1.51e-02	0.241000	9.53e-02
MICRORNA MIRNA BIOGENESIS	24	4.11e-02	-0.241000	1.66e-01
OTHER SEMAPHORIN INTERACTIONS	19	6.97e-02	-0.240000	2.24e-01
AMINE LIGAND BINDING RECEPTORS	29	2.57e-02	0.239000	1.34e-01
FCGR3A MEDIATED IL10 SYNTHESIS	35	1.44e-02	0.239000	9.28e-02
BASE EXCISION REPAIR AP SITE FORMATION	28	2.87e-02	-0.239000	1.37e-01
RHOBTB GTPASE CYCLE	35	1.46e-02	-0.239000	9.34e-02
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	8.12e-02	0.237000	2.50e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	1.94e-01	-0.237000	4.23e-01
ERYTHROPOIETIN ACTIVATES RAS	13	1.39e-01	0.237000	3.54e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	7.52e-02	0.236000	2.34e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	83	2.14e-04	-0.235000	4.50e-03
SIGNALING BY LEPTIN	10	1.98e-01	0.235000	4.29e-01
METABOLISM OF RNA	647	2.78e-24	-0.235000	8.22e-22
P75NTR SIGNALS VIA NF KB	16	1.04e-01	-0.235000	2.93e-01
METABOLISM OF AMINE DERIVED HORMONES	10	2.00e-01	-0.234000	4.30e-01
SHC MEDIATED CASCADE FGFR4	10	2.03e-01	0.232000	4.34e-01
AMINO ACIDS REGULATE MTORC1	51	4.17e-03	0.232000	4.31e-02
FCERI MEDIATED CA 2 MOBILIZATION	27	3.75e-02	0.231000	1.57e-01
ION CHANNEL TRANSPORT	143	1.84e-06	0.231000	6.59e-05
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	2.07e-01	-0.231000	4.37e-01
ACTIVATION OF SMO	16	1.12e-01	0.230000	3.08e-01
O LINKED GLYCOSYLATION OF MUCINS	41	1.12e-02	0.229000	7.99e-02
GLUCOSE METABOLISM	79	4.49e-04	0.228000	8.29e-03
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	4.39e-02	0.228000	1.71e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	2.84e-02	-0.228000	1.37e-01
GPVI MEDIATED ACTIVATION CASCADE	31	2.85e-02	0.227000	1.37e-01
CHAPERONE MEDIATED AUTOPHAGY	20	7.88e-02	-0.227000	2.44e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	13	1.60e-01	0.225000	3.79e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	8.16e-02	-0.225000	2.50e-01
SULFUR AMINO ACID METABOLISM	25	5.17e-02	0.225000	1.88e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	8.18e-02	0.225000	2.50e-01
FRS MEDIATED FGFR3 SIGNALING	14	1.47e-01	0.224000	3.64e-01
CYTOSOLIC TRNA AMINOACYLATION	24	5.76e-02	0.224000	1.97e-01
CELLULAR HEXOSE TRANSPORT	11	1.98e-01	0.224000	4.29e-01
COPII MEDIATED VESICLE TRANSPORT	65	1.85e-03	0.223000	2.40e-02
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	3.07e-03	-0.223000	3.48e-02
GAB1 SIGNALOSOME	14	1.49e-01	-0.223000	3.64e-01
STIMULI SENSING CHANNELS	78	6.87e-04	0.222000	1.14e-02
INTERLEUKIN 6 SIGNALING	10	2.24e-01	0.222000	4.58e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	1.83e-01	0.222000	4.06e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	16	1.24e-01	0.222000	3.31e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.84e-01	-0.221000	4.09e-01
HS GAG BIOSYNTHESIS	30	3.63e-02	0.221000	1.55e-01
G BETA GAMMA SIGNALLING THROUGH CDC42	19	9.65e-02	-0.220000	2.79e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	2.29e-01	0.220000	4.64e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	3.42e-02	0.220000	1.51e-01
PHOSPHOLIPID METABOLISM	187	2.28e-07	0.220000	1.08e-05
RNA POLYMERASE I PROMOTER ESCAPE	46	1.01e-02	-0.219000	7.78e-02
RHO GTPASES ACTIVATE CIT	18	1.08e-01	-0.219000	2.99e-01
TBC RABGAPS	42	1.42e-02	0.219000	9.25e-02
SIGNALLING TO ERKS	34	2.86e-02	0.217000	1.37e-01
INSULIN RECEPTOR RECYCLING	20	9.32e-02	0.217000	2.72e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	2.35e-01	0.217000	4.70e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	21	8.75e-02	0.215000	2.63e-01
NEUROTRANSMITTER RELEASE CYCLE	49	9.32e-03	0.215000	7.54e-02
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	7.47e-02	-0.215000	2.34e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	46	1.21e-02	-0.214000	8.43e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	1.82e-01	-0.214000	4.06e-01
SIGNALING BY NOTCH3	48	1.06e-02	-0.213000	7.84e-02
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	16	1.41e-01	0.213000	3.55e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	1.68e-01	0.213000	3.90e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	15	1.54e-01	0.213000	3.70e-01
MTORC1 MEDIATED SIGNALLING	24	7.15e-02	0.213000	2.27e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	6.07e-02	0.213000	2.05e-01
G1 S SPECIFIC TRANSCRIPTION	27	5.64e-02	0.212000	1.95e-01
SIGNAL AMPLIFICATION	31	4.19e-02	-0.211000	1.67e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	89	5.98e-04	0.211000	1.04e-02
CRISTAE FORMATION	31	4.36e-02	-0.209000	1.71e-01
CARGO CONCENTRATION IN THE ER	30	4.72e-02	0.209000	1.78e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	1.36e-01	-0.209000	3.48e-01
SHC MEDIATED CASCADE FGFR1	15	1.61e-01	0.209000	3.80e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	5.20e-02	0.209000	1.88e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	91	6.15e-04	0.208000	1.05e-02
ION HOMEOSTASIS	48	1.28e-02	0.208000	8.71e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS	23	8.48e-02	0.208000	2.56e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	5.98e-02	-0.206000	2.03e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	27	6.57e-02	0.205000	2.16e-01
APOPTOTIC EXECUTION PHASE	45	1.76e-02	0.205000	1.05e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	141	2.94e-05	0.204000	7.71e-04
RAB REGULATION OF TRAFFICKING	119	1.23e-04	0.204000	2.79e-03
HDACS DEACETYLATE HISTONES	45	1.84e-02	-0.203000	1.08e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	26	7.30e-02	-0.203000	2.30e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	61	6.09e-03	-0.203000	5.71e-02
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	34	4.06e-02	0.203000	1.65e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	198	9.20e-07	0.202000	3.62e-05
COMMON PATHWAY OF FIBRIN CLOT FORMATION	12	2.25e-01	0.202000	4.58e-01
RHOB GTPASE CYCLE	69	3.68e-03	0.202000	3.95e-02
MUCOPOLYSACCHARIDOSES	11	2.46e-01	0.202000	4.85e-01
KERATAN SULFATE KERATIN METABOLISM	32	4.80e-02	0.202000	1.80e-01
FRS MEDIATED FGFR4 SIGNALING	12	2.28e-01	0.201000	4.63e-01
G ALPHA 12 13 SIGNALLING EVENTS	76	2.50e-03	0.201000	2.98e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	74	3.04e-03	0.199000	3.48e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	85	1.55e-03	0.199000	2.17e-02
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	1.09e-02	0.199000	7.86e-02
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	171	7.64e-06	0.199000	2.51e-04
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	1.59e-01	0.198000	3.77e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA	14	2.02e-01	0.197000	4.32e-01
HEDGEHOG LIGAND BIOGENESIS	62	7.29e-03	-0.197000	6.47e-02
SIGNALING BY NODAL	16	1.74e-01	0.196000	3.96e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	1.88e-01	-0.196000	4.16e-01
CTLA4 INHIBITORY SIGNALING	20	1.29e-01	0.196000	3.40e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	2.05e-01	0.196000	4.35e-01
ONCOGENE INDUCED SENESCENCE	32	5.56e-02	-0.196000	1.94e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	84	1.97e-03	0.195000	2.50e-02
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	64	6.88e-03	-0.195000	6.20e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	9.87e-02	-0.195000	2.83e-01
NCAM1 INTERACTIONS	41	3.13e-02	-0.194000	1.45e-01
PLATELET AGGREGATION PLUG FORMATION	31	6.29e-02	0.193000	2.09e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	2.08e-02	0.193000	1.18e-01
STABILIZATION OF P53	55	1.34e-02	-0.193000	8.91e-02
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	2.51e-01	-0.191000	4.91e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	65	7.68e-03	-0.191000	6.58e-02
RECYCLING PATHWAY OF L1	40	3.65e-02	0.191000	1.56e-01
CARNITINE METABOLISM	14	2.16e-01	0.191000	4.49e-01
INTERLEUKIN 20 FAMILY SIGNALING	14	2.16e-01	0.191000	4.49e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	13	2.35e-01	-0.190000	4.70e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	2.90e-02	0.190000	1.38e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	2.35e-01	-0.190000	4.70e-01
PEROXISOMAL LIPID METABOLISM	27	8.79e-02	0.190000	2.63e-01
FRS MEDIATED FGFR1 SIGNALING	17	1.76e-01	0.190000	3.98e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	2.99e-01	0.190000	5.44e-01
ZINC TRANSPORTERS	16	1.90e-01	0.189000	4.19e-01
DISEASES OF IMMUNE SYSTEM	25	1.04e-01	0.188000	2.93e-01
RHO GTPASES ACTIVATE ROCKS	19	1.57e-01	-0.188000	3.75e-01
RHOG GTPASE CYCLE	74	5.37e-03	0.187000	5.25e-02
G0 AND EARLY G1	26	9.90e-02	0.187000	2.83e-01
BILE ACID AND BILE SALT METABOLISM	27	9.39e-02	0.186000	2.73e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	3.98e-02	0.186000	1.64e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	6.20e-02	0.185000	2.07e-01
NUCLEOBASE CATABOLISM	31	7.52e-02	0.185000	2.34e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	15	2.16e-01	-0.184000	4.49e-01
METABOLISM OF CARBOHYDRATES	260	3.20e-07	0.184000	1.45e-05
GENERATION OF SECOND MESSENGER MOLECULES	19	1.68e-01	-0.183000	3.90e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	8.88e-02	-0.183000	2.63e-01
COLLAGEN CHAIN TRIMERIZATION	42	4.06e-02	-0.183000	1.65e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	1.71e-02	-0.183000	1.03e-01
SIGNALING BY FGFR2 IN DISEASE	36	5.82e-02	-0.182000	1.98e-01
RAC1 GTPASE CYCLE	179	2.62e-05	0.182000	7.21e-04
PYRUVATE METABOLISM	27	1.01e-01	0.182000	2.89e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	2.31e-02	0.182000	1.27e-01
JOSEPHIN DOMAIN DUBS	11	2.96e-01	-0.182000	5.43e-01
INTERLEUKIN 17 SIGNALING	67	1.01e-02	0.182000	7.78e-02
SIGNALING BY INSULIN RECEPTOR	62	1.36e-02	0.181000	8.92e-02
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	31	8.08e-02	-0.181000	2.49e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	30	8.60e-02	-0.181000	2.59e-01
TELOMERE MAINTENANCE	77	6.07e-03	-0.181000	5.71e-02
EPIGENETIC REGULATION OF GENE EXPRESSION	102	1.62e-03	-0.181000	2.22e-02
PI3K EVENTS IN ERBB2 SIGNALING	15	2.26e-01	-0.181000	4.60e-01
HIV TRANSCRIPTION INITIATION	45	3.63e-02	-0.180000	1.55e-01
INTERFERON GAMMA SIGNALING	80	5.33e-03	-0.180000	5.24e-02
PROTEIN METHYLATION	17	1.98e-01	-0.180000	4.29e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	1.68e-02	-0.180000	1.03e-01
NEURONAL SYSTEM	373	2.58e-09	0.180000	1.53e-07
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	1.99e-01	0.180000	4.30e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	12	2.82e-01	0.179000	5.29e-01
HIV TRANSCRIPTION ELONGATION	42	4.45e-02	-0.179000	1.72e-01
SYNTHESIS OF PE	13	2.64e-01	0.179000	5.09e-01
POTASSIUM CHANNELS	91	3.20e-03	0.179000	3.53e-02
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	3.05e-01	0.179000	5.51e-01
HDR THROUGH MMEJ ALT NHEJ	10	3.28e-01	-0.179000	5.77e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	3.28e-01	0.179000	5.77e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	2.48e-01	0.178000	4.87e-01
INTEGRIN SIGNALING	24	1.32e-01	0.178000	3.43e-01
RHO GTPASES ACTIVATE PAKS	21	1.60e-01	-0.177000	3.79e-01
CHONDROITIN SULFATE BIOSYNTHESIS	18	1.93e-01	0.177000	4.22e-01
PEPTIDE LIGAND BINDING RECEPTORS	114	1.13e-03	-0.177000	1.69e-02
RAC2 GTPASE CYCLE	88	4.25e-03	0.176000	4.36e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	2.38e-01	0.176000	4.73e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	45	4.22e-02	-0.175000	1.67e-01
KERATAN SULFATE DEGRADATION	12	2.95e-01	0.175000	5.43e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.86e-02	-0.174000	1.60e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	50	3.35e-02	-0.174000	1.49e-01
PREGNENOLONE BIOSYNTHESIS	12	2.97e-01	-0.174000	5.43e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	108	1.83e-03	0.174000	2.40e-02
PI 3K CASCADE FGFR3	12	2.98e-01	0.174000	5.43e-01
SIGNALING BY VEGF	103	2.41e-03	0.173000	2.90e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	23	1.51e-01	-0.173000	3.64e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	70	1.25e-02	-0.173000	8.60e-02
NONHOMOLOGOUS END JOINING NHEJ	42	5.35e-02	-0.172000	1.91e-01
DEGRADATION OF DVL	56	2.60e-02	-0.172000	1.34e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	186	5.29e-05	0.172000	1.33e-03
NUCLEAR ENVELOPE BREAKDOWN	49	3.75e-02	0.172000	1.57e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	7.09e-02	-0.172000	2.26e-01
MEMBRANE TRAFFICKING	581	2.13e-12	0.171000	1.58e-10
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	5.82e-02	-0.171000	1.98e-01
GLYCOLYSIS	65	1.72e-02	0.171000	1.03e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	1.18e-01	0.170000	3.21e-01
PHASE 0 RAPID DEPOLARISATION	28	1.19e-01	0.170000	3.21e-01
COLLAGEN DEGRADATION	52	3.41e-02	-0.170000	1.51e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	2.55e-01	-0.170000	4.97e-01
RNA POLYMERASE I TRANSCRIPTION	66	1.72e-02	-0.170000	1.03e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	2.14e-02	0.169000	1.20e-01
RHOU GTPASE CYCLE	34	8.88e-02	0.169000	2.63e-01
E2F MEDIATED REGULATION OF DNA REPLICATION	20	1.92e-01	0.169000	4.21e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	2.43e-01	-0.169000	4.82e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	9.44e-02	-0.168000	2.74e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	1.63e-01	0.168000	3.82e-01
GLYCOGEN METABOLISM	25	1.48e-01	0.167000	3.64e-01
PYROPTOSIS	21	1.85e-01	-0.167000	4.09e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	68	1.72e-02	-0.167000	1.03e-01
VESICLE MEDIATED TRANSPORT	615	1.78e-12	0.167000	1.40e-10
NEGATIVE REGULATION OF MAPK PATHWAY	42	6.12e-02	0.167000	2.06e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	2.68e-02	-0.167000	1.36e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	1.03e-01	-0.166000	2.93e-01
RHOA GTPASE CYCLE	144	5.82e-04	0.166000	1.03e-02
VLDLR INTERNALISATION AND DEGRADATION	11	3.42e-01	0.165000	5.92e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	93	5.89e-03	0.165000	5.61e-02
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	1.12e-02	-0.165000	7.99e-02
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	92	6.45e-03	0.164000	5.90e-02
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	3.25e-01	0.164000	5.72e-01
HEME SIGNALING	45	5.77e-02	0.164000	1.97e-01
RORA ACTIVATES GENE EXPRESSION	18	2.30e-01	0.163000	4.66e-01
SYNTHESIS OF PA	29	1.28e-01	0.163000	3.37e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	27	1.42e-01	0.163000	3.58e-01
METABOLISM OF PORPHYRINS	19	2.20e-01	0.163000	4.54e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	1.02e-01	0.162000	2.89e-01
INSULIN RECEPTOR SIGNALLING CASCADE	43	6.61e-02	0.162000	2.17e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT	11	3.53e-01	0.162000	6.00e-01
LYSINE CATABOLISM	11	3.54e-01	0.161000	6.01e-01
ENDOSOMAL VACUOLAR PATHWAY	11	3.55e-01	-0.161000	6.01e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	20	2.13e-01	-0.161000	4.47e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	1.04e-02	0.161000	7.84e-02
PLATELET SENSITIZATION BY LDL	16	2.67e-01	0.160000	5.12e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	27	1.49e-01	-0.160000	3.64e-01
GLYCOSAMINOGLYCAN METABOLISM	116	2.98e-03	0.160000	3.48e-02
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	2.05e-01	0.160000	4.35e-01
TRP CHANNELS	20	2.18e-01	0.159000	4.52e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	2.43e-01	-0.159000	4.82e-01
NUCLEAR IMPORT OF REV PROTEIN	32	1.19e-01	0.159000	3.21e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	20	2.21e-01	-0.158000	4.54e-01
ESTROGEN DEPENDENT GENE EXPRESSION	103	5.67e-03	-0.158000	5.44e-02
SIGNALING BY FLT3 FUSION PROTEINS	19	2.34e-01	0.158000	4.70e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	245	2.18e-05	0.158000	6.43e-04
FATTY ACID METABOLISM	148	9.43e-04	0.158000	1.47e-02
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	9.43e-03	0.158000	7.56e-02
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	4.56e-02	-0.157000	1.74e-01
INSULIN PROCESSING	25	1.74e-01	0.157000	3.96e-01
TOLL LIKE RECEPTOR CASCADES	138	1.45e-03	0.157000	2.09e-02
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	9.88e-02	0.157000	2.83e-01
CD28 CO STIMULATION	31	1.32e-01	0.156000	3.43e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	180	3.04e-04	-0.156000	6.19e-03
SIGNALING BY FGFR2	63	3.22e-02	-0.156000	1.47e-01
GAP JUNCTION DEGRADATION	11	3.70e-01	0.156000	6.15e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	85	1.30e-02	-0.156000	8.83e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	1.61e-01	0.156000	3.80e-01
GOLGI TO ER RETROGRADE TRANSPORT	120	3.24e-03	0.156000	3.55e-02
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	3.51e-01	0.156000	5.98e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	3.73e-01	0.155000	6.16e-01
NUCLEOBASE BIOSYNTHESIS	15	2.98e-01	0.155000	5.43e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	2.44e-01	0.155000	4.83e-01
DEGRADATION OF AXIN	54	4.96e-02	-0.155000	1.84e-01
CELL CELL JUNCTION ORGANIZATION	52	5.55e-02	0.154000	1.94e-01
ENDOGENOUS STEROLS	20	2.35e-01	-0.153000	4.70e-01
SYNAPTIC ADHESION LIKE MOLECULES	21	2.24e-01	0.153000	4.58e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	31	1.40e-01	-0.153000	3.55e-01
FERTILIZATION	11	3.82e-01	-0.152000	6.21e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	5.53e-02	-0.152000	1.94e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	4.05e-01	0.152000	6.41e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	1.64e-01	-0.152000	3.83e-01
METABOLISM OF LIPIDS	619	1.24e-10	0.152000	8.12e-09
TRANSPORT OF SMALL MOLECULES	590	3.27e-10	0.152000	2.04e-08
CELLULAR RESPONSE TO HYPOXIA	73	2.51e-02	-0.152000	1.34e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	1.58e-01	-0.152000	3.77e-01
CHROMOSOME MAINTENANCE	100	8.91e-03	-0.151000	7.26e-02
P75 NTR RECEPTOR MEDIATED SIGNALLING	95	1.09e-02	0.151000	7.86e-02
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	1.59e-01	0.151000	3.77e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	2.27e-02	0.151000	1.26e-01
REGULATION OF IFNA SIGNALING	12	3.64e-01	-0.151000	6.09e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	2.51e-02	-0.151000	1.34e-01
BASE EXCISION REPAIR	55	5.34e-02	-0.151000	1.91e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	2.97e-01	-0.151000	5.43e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	16	2.98e-01	0.150000	5.43e-01
ASSEMBLY OF THE HIV VIRION	16	2.99e-01	-0.150000	5.43e-01
CGMP EFFECTS	15	3.15e-01	0.150000	5.62e-01
AGGREPHAGY	34	1.30e-01	-0.150000	3.41e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	1.62e-01	0.150000	3.82e-01
CARDIAC CONDUCTION	107	7.46e-03	0.150000	6.52e-02
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	36	1.20e-01	-0.150000	3.22e-01
SHC1 EVENTS IN EGFR SIGNALING	11	3.91e-01	-0.149000	6.30e-01
POLYMERASE SWITCHING	14	3.34e-01	-0.149000	5.85e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	12	3.73e-01	0.149000	6.16e-01
MHC CLASS II ANTIGEN PRESENTATION	102	9.60e-03	0.148000	7.60e-02
REGULATION OF SIGNALING BY CBL	22	2.32e-01	0.147000	4.69e-01
RNA POLYMERASE III CHAIN ELONGATION	18	2.81e-01	0.147000	5.26e-01
PURINE SALVAGE	12	3.78e-01	0.147000	6.21e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	25	2.04e-01	0.147000	4.35e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	1.28e-01	0.147000	3.37e-01
PURINE CATABOLISM	16	3.10e-01	0.146000	5.57e-01
CELL JUNCTION ORGANIZATION	77	2.63e-02	0.146000	1.35e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	5.20e-02	-0.146000	1.88e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	104	1.01e-02	0.146000	7.78e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	4.02e-01	0.146000	6.40e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	59	5.37e-02	-0.145000	1.91e-01
IRS MEDIATED SIGNALLING	38	1.22e-01	0.145000	3.25e-01
PI 3K CASCADE FGFR1	15	3.33e-01	0.145000	5.84e-01
ASPARAGINE N LINKED GLYCOSYLATION	285	2.84e-05	0.144000	7.62e-04
TRANSCRIPTION OF THE HIV GENOME	67	4.16e-02	-0.144000	1.66e-01
RAS PROCESSING	23	2.33e-01	0.144000	4.70e-01
CDC42 GTPASE CYCLE	154	2.18e-03	0.143000	2.71e-02
MAPK6 MAPK4 SIGNALING	85	2.27e-02	-0.143000	1.26e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	3.73e-01	0.143000	6.16e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	69	4.13e-02	-0.142000	1.66e-01
TRANS GOLGI NETWORK VESICLE BUDDING	70	4.00e-02	0.142000	1.64e-01
SIGNALING BY RETINOIC ACID	34	1.52e-01	0.142000	3.66e-01
RHOC GTPASE CYCLE	74	3.50e-02	0.142000	1.53e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	1.72e-01	-0.142000	3.94e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	1.73e-01	-0.142000	3.95e-01
RAC3 GTPASE CYCLE	90	2.06e-02	0.141000	1.17e-01
SIGNALING BY FGFR	73	3.70e-02	-0.141000	1.57e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	6.78e-02	0.141000	2.21e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	68	4.42e-02	-0.141000	1.72e-01
INTEGRIN CELL SURFACE INTERACTIONS	74	3.59e-02	-0.141000	1.55e-01
DISEASES OF GLYCOSYLATION	124	6.79e-03	0.141000	6.17e-02
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	8.84e-02	0.141000	2.63e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	3.17e-01	0.140000	5.65e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	3.66e-01	0.139000	6.11e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	2.48e-01	-0.139000	4.87e-01
TRAFFICKING OF AMPA RECEPTORS	31	1.80e-01	0.139000	4.04e-01
POLO LIKE KINASE MEDIATED EVENTS	13	3.86e-01	-0.139000	6.25e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	4.06e-01	0.139000	6.41e-01
COLLAGEN FORMATION	82	3.06e-02	-0.138000	1.42e-01
NEPHRIN FAMILY INTERACTIONS	21	2.73e-01	0.138000	5.16e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	4.29e-01	-0.138000	6.63e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	23	2.53e-01	0.138000	4.94e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	6.32e-02	-0.138000	2.09e-01
O LINKED GLYCOSYLATION	86	2.75e-02	0.138000	1.37e-01
SLC TRANSPORTER DISORDERS	77	3.74e-02	0.137000	1.57e-01
PI3K AKT SIGNALING IN CANCER	86	2.82e-02	0.137000	1.37e-01
DEGRADATION OF GLI1 BY THE PROTEASOME	58	7.16e-02	-0.137000	2.27e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	34	1.70e-01	-0.136000	3.91e-01
PI 3K CASCADE FGFR4	10	4.58e-01	0.136000	6.94e-01
MEIOTIC RECOMBINATION	38	1.49e-01	-0.135000	3.64e-01
AMYLOID FIBER FORMATION	56	8.01e-02	-0.135000	2.47e-01
G1 S DNA DAMAGE CHECKPOINTS	66	5.76e-02	-0.135000	1.97e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	43	1.25e-01	-0.135000	3.33e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	2.44e-02	0.135000	1.33e-01
PLASMA LIPOPROTEIN REMODELING	15	3.67e-01	0.135000	6.11e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	1.36e-01	0.135000	3.49e-01
L1CAM INTERACTIONS	107	1.63e-02	0.134000	1.01e-01
MITOTIC PROPHASE	93	2.52e-02	0.134000	1.34e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	36	1.65e-01	0.134000	3.85e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	28	2.22e-01	-0.133000	4.56e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	4.24e-01	0.133000	6.59e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	288	1.02e-04	0.133000	2.37e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	11	4.45e-01	0.133000	6.79e-01
ONCOGENIC MAPK SIGNALING	76	4.49e-02	0.133000	1.72e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	153	4.53e-03	-0.133000	4.62e-02
MEIOTIC SYNAPSIS	39	1.51e-01	-0.133000	3.64e-01
CYTOPROTECTION BY HMOX1	120	1.20e-02	-0.133000	8.37e-02
OPIOID SIGNALLING	87	3.27e-02	0.133000	1.48e-01
PENTOSE PHOSPHATE PATHWAY	13	4.09e-01	-0.132000	6.44e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	55	9.05e-02	-0.132000	2.66e-01
SIGNALING BY HIPPO	20	3.07e-01	0.132000	5.54e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	605	3.31e-08	-0.132000	1.78e-06
MRNA CAPPING	29	2.19e-01	-0.132000	4.53e-01
OXIDATIVE STRESS INDUCED SENESCENCE	77	4.59e-02	-0.132000	1.75e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	1.19e-01	-0.132000	3.21e-01
METHYLATION	11	4.50e-01	0.131000	6.84e-01
RMTS METHYLATE HISTONE ARGININES	42	1.40e-01	-0.131000	3.55e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	1.66e-01	0.131000	3.87e-01
ANTIMICROBIAL PEPTIDES	17	3.48e-01	0.131000	5.95e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	35	1.79e-01	0.131000	4.04e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	3.80e-01	-0.131000	6.21e-01
LDL CLEARANCE	15	3.80e-01	0.131000	6.21e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	183	2.31e-03	0.131000	2.82e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	64	7.08e-02	-0.131000	2.26e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	1.75e-01	0.131000	3.98e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	110	1.84e-02	-0.130000	1.08e-01
CS DS DEGRADATION	14	3.99e-01	-0.130000	6.39e-01
COHESIN LOADING ONTO CHROMATIN	10	4.79e-01	0.129000	7.10e-01
NEDDYLATION	218	1.04e-03	0.129000	1.57e-02
GP1B IX V ACTIVATION SIGNALLING	10	4.80e-01	0.129000	7.11e-01
ANTIGEN PROCESSING CROSS PRESENTATION	98	2.79e-02	-0.129000	1.37e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	1.77e-01	0.128000	4.00e-01
SIGNALING BY FGFR4 IN DISEASE	10	4.83e-01	-0.128000	7.13e-01
NEUREXINS AND NEUROLIGINS	54	1.05e-01	0.128000	2.95e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	3.82e-01	0.126000	6.21e-01
REGULATED NECROSIS	46	1.39e-01	-0.126000	3.54e-01
SIGNALING BY NTRKS	131	1.33e-02	0.125000	8.85e-02
NEGATIVE REGULATION OF FGFR1 SIGNALING	26	2.69e-01	0.125000	5.14e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	21	3.21e-01	0.125000	5.67e-01
RHO GTPASES ACTIVATE KTN1	11	4.74e-01	0.125000	7.03e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	7.05e-02	-0.124000	2.26e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	3.76e-01	-0.124000	6.18e-01
RHO GTPASES ACTIVATE PKNS	46	1.45e-01	-0.124000	3.63e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	46	1.47e-01	0.124000	3.64e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	2.13e-01	-0.124000	4.47e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	3.52e-01	-0.123000	6.00e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	3.40e-01	0.123000	5.90e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	4.42e-01	0.123000	6.76e-01
CLATHRIN MEDIATED ENDOCYTOSIS	132	1.50e-02	0.123000	9.53e-02
CELL CELL COMMUNICATION	108	2.78e-02	0.123000	1.37e-01
METABOLISM OF COFACTORS	19	3.57e-01	-0.122000	6.03e-01
THE PHOTOTRANSDUCTION CASCADE	21	3.33e-01	-0.122000	5.84e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	2.64e-01	0.122000	5.09e-01
RESOLUTION OF ABASIC SITES AP SITES	37	2.00e-01	-0.122000	4.30e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	4.66e-01	0.122000	6.99e-01
SIGNALING BY ERBB2 IN CANCER	25	2.93e-01	-0.122000	5.42e-01
DERMATAN SULFATE BIOSYNTHESIS	11	4.86e-01	-0.121000	7.14e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	43	1.69e-01	0.121000	3.91e-01
RHOF GTPASE CYCLE	41	1.80e-01	0.121000	4.04e-01
NERVOUS SYSTEM DEVELOPMENT	553	1.25e-06	-0.121000	4.63e-05
PHASE 2 PLATEAU PHASE	12	4.69e-01	-0.121000	7.00e-01
NUCLEAR SIGNALING BY ERBB4	31	2.46e-01	-0.120000	4.85e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	2.19e-01	0.120000	4.53e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	4.91e-01	-0.120000	7.18e-01
TRIGLYCERIDE METABOLISM	23	3.20e-01	0.120000	5.67e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	5.15e-01	0.119000	7.34e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	5.15e-01	0.119000	7.34e-01
TRNA AMINOACYLATION	42	1.83e-01	0.119000	4.06e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	87	5.61e-02	0.119000	1.94e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	2.70e-01	-0.118000	5.14e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	4.60e-01	-0.118000	6.96e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	7.69e-03	-0.118000	6.58e-02
AURKA ACTIVATION BY TPX2	72	8.45e-02	0.118000	2.56e-01
ABC TRANSPORTER DISORDERS	69	9.18e-02	-0.117000	2.69e-01
SIGNALING BY BMP	25	3.10e-01	0.117000	5.57e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	30	2.67e-01	0.117000	5.12e-01
UCH PROTEINASES	90	5.51e-02	-0.117000	1.94e-01
FLT3 SIGNALING IN DISEASE	28	2.85e-01	0.117000	5.32e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	51	1.50e-01	-0.117000	3.64e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	21	3.56e-01	0.116000	6.03e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	61	1.17e-01	-0.116000	3.18e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	1.64e-01	-0.116000	3.83e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	4.69e-01	-0.116000	7.00e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	64	1.12e-01	0.115000	3.08e-01
METAL ION SLC TRANSPORTERS	25	3.20e-01	0.115000	5.67e-01
ACYL CHAIN REMODELLING OF PE	17	4.13e-01	0.115000	6.47e-01
SIGNALING BY NOTCH	187	6.96e-03	-0.115000	6.23e-02
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	120	3.03e-02	0.115000	1.42e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	5.11e-01	0.115000	7.34e-01
POTENTIAL THERAPEUTICS FOR SARS	77	8.37e-02	-0.114000	2.55e-01
INTERFERON SIGNALING	168	1.09e-02	-0.114000	7.86e-02
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	2.75e-01	0.113000	5.18e-01
TRANSLESION SYNTHESIS BY POLK	17	4.19e-01	-0.113000	6.56e-01
GLUTATHIONE SYNTHESIS AND RECYCLING	11	5.17e-01	0.113000	7.35e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	11	5.17e-01	0.113000	7.35e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	4.35e-01	0.113000	6.68e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	44	1.98e-01	0.112000	4.29e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	12	5.01e-01	0.112000	7.28e-01
RESOLUTION OF SISTER CHROMATID COHESION	105	4.72e-02	0.112000	1.78e-01
DEATH RECEPTOR SIGNALLING	134	2.55e-02	0.112000	1.34e-01
G2 M CHECKPOINTS	133	2.61e-02	-0.112000	1.34e-01
SIGNALING BY NOTCH2	33	2.68e-01	-0.111000	5.13e-01
REGULATION OF RAS BY GAPS	67	1.17e-01	-0.111000	3.18e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	19	4.03e-01	0.111000	6.40e-01
SIGNALLING TO RAS	20	3.93e-01	0.110000	6.31e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	349	4.21e-04	0.110000	8.01e-03
NOTCH HLH TRANSCRIPTION PATHWAY	28	3.14e-01	-0.110000	5.61e-01
TNFR2 NON CANONICAL NF KB PATHWAY	81	8.82e-02	-0.110000	2.63e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	4.09e-01	0.109000	6.44e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	1.43e-01	0.109000	3.60e-01
FCERI MEDIATED MAPK ACTIVATION	29	3.08e-01	0.109000	5.55e-01
ADHERENS JUNCTIONS INTERACTIONS	32	2.86e-01	0.109000	5.33e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	1.53e-01	0.108000	3.69e-01
PROTEIN FOLDING	90	7.67e-02	-0.108000	2.38e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	3.41e-01	0.108000	5.90e-01
HS GAG DEGRADATION	20	4.03e-01	0.108000	6.40e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	10	5.54e-01	0.108000	7.61e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	71	1.17e-01	0.108000	3.18e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	3.94e-01	0.107000	6.32e-01
G2 M DNA DAMAGE CHECKPOINT	65	1.35e-01	-0.107000	3.48e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	3.19e-01	0.107000	5.67e-01
DNA DOUBLE STRAND BREAK RESPONSE	51	1.88e-01	-0.107000	4.16e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	50	1.93e-01	0.106000	4.22e-01
SIGNALING BY PDGFR IN DISEASE	20	4.10e-01	0.106000	6.44e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	2.87e-01	0.106000	5.34e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	4.65e-01	-0.106000	6.99e-01
DISEASES OF METABOLISM	198	1.08e-02	0.105000	7.86e-02
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	25	3.63e-01	-0.105000	6.09e-01
REPRODUCTION	75	1.16e-01	-0.105000	3.17e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	2.44e-01	0.105000	4.83e-01
ADAPTIVE IMMUNE SYSTEM	614	1.04e-05	0.105000	3.31e-04
FLT3 SIGNALING	36	2.78e-01	0.105000	5.21e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	5.50e-01	0.104000	7.61e-01
REGULATION OF FZD BY UBIQUITINATION	20	4.24e-01	0.103000	6.59e-01
COMPLEMENT CASCADE	29	3.37e-01	-0.103000	5.88e-01
TRANSPORT OF ORGANIC ANIONS	10	5.74e-01	0.103000	7.76e-01
CD28 DEPENDENT VAV1 PATHWAY	11	5.55e-01	-0.103000	7.61e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	3.07e-01	0.103000	5.54e-01
RAB GERANYLGERANYLATION	59	1.73e-01	0.103000	3.95e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	4.92e-01	0.102000	7.19e-01
INFECTIOUS DISEASE	740	2.45e-06	-0.102000	8.51e-05
TRANSCRIPTIONAL REGULATION BY VENTX	35	2.96e-01	-0.102000	5.43e-01
IRAK1 RECRUITS IKK COMPLEX	14	5.08e-01	-0.102000	7.33e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	3.11e-01	0.102000	5.57e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	4.82e-01	0.101000	7.12e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	94	8.97e-02	-0.101000	2.64e-01
ORC1 REMOVAL FROM CHROMATIN	68	1.49e-01	-0.101000	3.64e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	5.28e-01	0.101000	7.44e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	40	2.70e-01	0.101000	5.14e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	71	1.46e-01	-0.099900	3.63e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	3.87e-01	-0.099900	6.25e-01
GLYCOGEN SYNTHESIS	14	5.18e-01	0.099900	7.35e-01
INTERLEUKIN 7 SIGNALING	18	4.65e-01	0.099600	6.99e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	4.91e-01	-0.099400	7.18e-01
LATE ENDOSOMAL MICROAUTOPHAGY	31	3.40e-01	-0.099100	5.90e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	193	1.81e-02	-0.098700	1.08e-01
IRON UPTAKE AND TRANSPORT	52	2.20e-01	0.098300	4.54e-01
EGFR DOWNREGULATION	28	3.70e-01	-0.098000	6.15e-01
INFLAMMASOMES	19	4.61e-01	-0.097600	6.96e-01
CONDENSATION OF PROPHASE CHROMOSOMES	27	3.80e-01	-0.097600	6.21e-01
SIGNALING BY ERBB4	57	2.04e-01	-0.097300	4.35e-01
SEMAPHORIN INTERACTIONS	64	1.79e-01	-0.097200	4.03e-01
ERBB2 ACTIVATES PTK6 SIGNALING	11	5.77e-01	-0.097000	7.79e-01
MEIOSIS	64	1.80e-01	-0.096800	4.04e-01
ESR MEDIATED SIGNALING	166	3.24e-02	-0.096300	1.48e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	40	2.93e-01	0.096000	5.42e-01
PYRIMIDINE SALVAGE	10	5.99e-01	0.096000	7.92e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	59	2.04e-01	0.095700	4.35e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	33	3.45e-01	0.095100	5.93e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1220	2.98e-08	0.095000	1.67e-06
REGULATION OF IFNG SIGNALING	13	5.53e-01	0.094900	7.61e-01
SIGNALING BY NOTCH4	83	1.37e-01	-0.094400	3.51e-01
OTHER INTERLEUKIN SIGNALING	20	4.65e-01	0.094400	6.99e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	79	1.48e-01	0.094200	3.64e-01
NUCLEOTIDE SALVAGE	21	4.56e-01	0.093900	6.92e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	12	5.75e-01	0.093600	7.76e-01
GENE SILENCING BY RNA	84	1.38e-01	-0.093600	3.53e-01
TELOMERE EXTENSION BY TELOMERASE	22	4.49e-01	-0.093200	6.84e-01
SENSORY PROCESSING OF SOUND	60	2.12e-01	0.093200	4.47e-01
DNA STRAND ELONGATION	32	3.64e-01	0.092800	6.09e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	4.84e-01	0.092700	7.13e-01
REGULATION OF BACH1 ACTIVITY	11	5.96e-01	-0.092400	7.90e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	30	3.81e-01	-0.092400	6.21e-01
CRMPS IN SEMA3A SIGNALING	16	5.24e-01	0.092000	7.41e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	2.00e-01	-0.091900	4.30e-01
MITOTIC PROMETAPHASE	180	3.36e-02	0.091900	1.49e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	4.30e-01	-0.091300	6.63e-01
PTEN REGULATION	136	6.76e-02	-0.090800	2.21e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.86e-01	-0.090700	7.85e-01
SIGNALING BY SCF KIT	41	3.15e-01	0.090700	5.62e-01
FRS MEDIATED FGFR2 SIGNALING	18	5.06e-01	0.090600	7.32e-01
METABOLISM OF STEROIDS	118	8.96e-02	0.090500	2.64e-01
GPCR LIGAND BINDING	276	9.83e-03	-0.090400	7.69e-02
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	6.05e-01	-0.090000	7.94e-01
GLYCOGEN STORAGE DISEASES	12	5.90e-01	0.089800	7.88e-01
MITOTIC SPINDLE CHECKPOINT	100	1.21e-01	0.089800	3.24e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	3.21e-01	0.089500	5.67e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	6.08e-01	-0.089300	7.94e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	4.69e-01	0.089200	7.00e-01
THE NLRP3 INFLAMMASOME	15	5.50e-01	-0.089100	7.61e-01
SIGNALING BY ACTIVIN	12	5.93e-01	-0.089000	7.89e-01
PEROXISOMAL PROTEIN IMPORT	60	2.34e-01	0.088800	4.70e-01
RHOBTB1 GTPASE CYCLE	23	4.61e-01	-0.088700	6.96e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	86	1.56e-01	0.088600	3.73e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	4.72e-01	-0.088500	7.02e-01
INTEGRATION OF ENERGY METABOLISM	98	1.30e-01	0.088500	3.41e-01
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION	10	6.29e-01	0.088200	8.06e-01
PLATELET HOMEOSTASIS	79	1.75e-01	0.088200	3.98e-01
CIRCADIAN CLOCK	68	2.12e-01	0.087700	4.47e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	92	1.47e-01	0.087500	3.64e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	25	4.50e-01	-0.087400	6.84e-01
SIGNALING BY NOTCH1	75	1.93e-01	-0.087000	4.22e-01
SIGNALING BY ERYTHROPOIETIN	24	4.67e-01	0.085800	7.00e-01
FORMATION OF APOPTOSOME	10	6.39e-01	0.085700	8.11e-01
GABA RECEPTOR ACTIVATION	55	2.72e-01	0.085600	5.16e-01
ELASTIC FIBRE FORMATION	39	3.60e-01	0.084800	6.05e-01
PROLACTIN RECEPTOR SIGNALING	12	6.11e-01	0.084800	7.95e-01
AUTOPHAGY	139	8.48e-02	0.084700	2.56e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	1.71e-01	-0.084500	3.92e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	54	2.85e-01	-0.084100	5.32e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	5.17e-01	0.083800	7.35e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	4.28e-01	0.083700	6.62e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	17	5.54e-01	0.083000	7.61e-01
DEFECTS IN COBALAMIN B12 METABOLISM	13	6.05e-01	0.082900	7.93e-01
TCR SIGNALING	101	1.50e-01	-0.082900	3.64e-01
RHOJ GTPASE CYCLE	55	2.88e-01	0.082800	5.35e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	5.93e-01	0.082600	7.89e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	6.51e-01	-0.082600	8.20e-01
DISEASES OF MITOTIC CELL CYCLE	37	3.87e-01	-0.082200	6.25e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	14	5.95e-01	0.082000	7.90e-01
CELLULAR RESPONSE TO HEAT STRESS	96	1.65e-01	-0.082000	3.85e-01
NUCLEAR ENVELOPE NE REASSEMBLY	64	2.57e-01	0.081900	5.00e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	5.84e-01	0.081700	7.83e-01
HEMOSTASIS	482	2.21e-03	0.081600	2.71e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	2.63e-01	-0.081600	5.09e-01
FCERI MEDIATED NF KB ACTIVATION	78	2.15e-01	-0.081300	4.49e-01
NETRIN 1 SIGNALING	50	3.21e-01	0.081200	5.67e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	17	5.63e-01	0.081100	7.67e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	38	3.88e-01	-0.081000	6.25e-01
METABOLISM OF POLYAMINES	58	2.88e-01	-0.080800	5.34e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES	322	1.32e-02	-0.080500	8.85e-02
EXTRA NUCLEAR ESTROGEN SIGNALING	67	2.56e-01	-0.080300	4.98e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	6.62e-01	0.079700	8.24e-01
PKMTS METHYLATE HISTONE LYSINES	47	3.46e-01	-0.079500	5.93e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	3.41e-01	-0.079500	5.90e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	3.73e-01	-0.079400	6.16e-01
INTERLEUKIN 15 SIGNALING	13	6.21e-01	0.079300	8.01e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	24	5.02e-01	-0.079200	7.29e-01
P38MAPK EVENTS	13	6.21e-01	0.079100	8.01e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	2.25e-01	-0.079100	4.58e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	5.74e-01	-0.078800	7.76e-01
MET ACTIVATES PTK2 SIGNALING	28	4.71e-01	-0.078700	7.01e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	5.14e-01	-0.078600	7.34e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	6.12e-01	0.078400	7.95e-01
RHO GTPASES ACTIVATE FORMINS	122	1.36e-01	0.078300	3.48e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	633	8.87e-04	0.077700	1.42e-02
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	6.03e-01	0.077600	7.93e-01
PROTEIN UBIQUITINATION	70	2.64e-01	-0.077300	5.09e-01
DEVELOPMENTAL BIOLOGY	832	1.68e-04	-0.077200	3.67e-03
NR1H2 AND NR1H3 MEDIATED SIGNALING	39	4.05e-01	0.077000	6.41e-01
RET SIGNALING	37	4.20e-01	0.076600	6.57e-01
EPHB MEDIATED FORWARD SIGNALING	42	3.91e-01	-0.076500	6.30e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	25	5.08e-01	-0.076500	7.33e-01
SIGNALING BY KIT IN DISEASE	20	5.55e-01	0.076300	7.61e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	77	2.48e-01	-0.076200	4.87e-01
METABOLISM OF VITAMINS AND COFACTORS	155	1.06e-01	0.075400	2.96e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	5.51e-01	-0.075200	7.61e-01
REGULATION OF KIT SIGNALING	16	6.03e-01	0.075100	7.93e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	13	6.40e-01	-0.075000	8.11e-01
EXTENSION OF TELOMERES	49	3.64e-01	-0.075000	6.09e-01
INTERLEUKIN 12 SIGNALING	36	4.37e-01	-0.074900	6.69e-01
PLASMA LIPOPROTEIN CLEARANCE	26	5.11e-01	0.074400	7.34e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	21	5.55e-01	0.074400	7.61e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	6.57e-01	0.074000	8.21e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	6.09e-01	0.073900	7.94e-01
SMOOTH MUSCLE CONTRACTION	32	4.69e-01	-0.073900	7.00e-01
SIGNALING BY FGFR IN DISEASE	55	3.48e-01	-0.073200	5.95e-01
COSTIMULATION BY THE CD28 FAMILY	49	3.77e-01	0.073000	6.19e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	97	2.15e-01	-0.072800	4.49e-01
RHO GTPASE CYCLE	427	1.04e-02	0.072500	7.84e-02
LYSOSOME VESICLE BIOGENESIS	33	4.71e-01	0.072500	7.01e-01
ARACHIDONIC ACID METABOLISM	41	4.23e-01	0.072400	6.59e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	5.57e-01	0.072400	7.62e-01
RND2 GTPASE CYCLE	39	4.35e-01	-0.072200	6.68e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	3.88e-01	0.072100	6.25e-01
RND3 GTPASE CYCLE	39	4.36e-01	-0.072100	6.69e-01
RHO GTPASE EFFECTORS	252	5.01e-02	0.071800	1.85e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	6.55e-01	0.071700	8.21e-01
SIGNALING BY NTRK3 TRKC	17	6.13e-01	-0.070800	7.95e-01
CROSSLINKING OF COLLAGEN FIBRILS	17	6.14e-01	-0.070800	7.95e-01
HOMOLOGY DIRECTED REPAIR	105	2.12e-01	-0.070500	4.47e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	5.87e-01	0.070100	7.85e-01
RHO GTPASES ACTIVATE IQGAPS	24	5.53e-01	0.070000	7.61e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	5.54e-01	-0.069800	7.61e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	5.54e-01	-0.069800	7.61e-01
CD209 DC SIGN SIGNALING	18	6.09e-01	0.069700	7.94e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	7.04e-01	0.069300	8.50e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	5.21e-01	0.068800	7.38e-01
PERK REGULATES GENE EXPRESSION	28	5.29e-01	-0.068800	7.44e-01
PROCESSING OF SMDT1	16	6.35e-01	0.068500	8.11e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	2.70e-01	-0.068400	5.14e-01
NEGATIVE REGULATION OF FLT3	14	6.58e-01	-0.068400	8.21e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	60	3.62e-01	-0.068100	6.08e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	64	3.46e-01	-0.068100	5.94e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	6.49e-01	0.067900	8.20e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	7.10e-01	-0.067900	8.52e-01
METABOLISM OF STEROID HORMONES	22	5.83e-01	-0.067700	7.83e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	6.29e-01	-0.067700	8.06e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	25	5.58e-01	0.067600	7.63e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	6.75e-01	-0.067200	8.29e-01
INITIAL TRIGGERING OF COMPLEMENT	13	6.77e-01	-0.066800	8.30e-01
BUDDING AND MATURATION OF HIV VIRION	27	5.48e-01	-0.066800	7.61e-01
DISEASES OF PROGRAMMED CELL DEATH	53	4.03e-01	-0.066500	6.40e-01
INTERLEUKIN 12 FAMILY SIGNALING	42	4.58e-01	-0.066100	6.94e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	4.81e-01	0.066000	7.12e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	6.58e-01	0.066000	8.21e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	4.03e-01	0.065900	6.40e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	6.70e-01	-0.065800	8.26e-01
METABOLISM OF NUCLEOTIDES	92	2.77e-01	0.065700	5.20e-01
REGULATION OF BETA CELL DEVELOPMENT	29	5.47e-01	0.064700	7.61e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	6.87e-01	0.064500	8.38e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	3.82e-01	-0.064200	6.21e-01
PEXOPHAGY	11	7.13e-01	-0.064000	8.54e-01
DUAL INCISION IN GG NER	40	4.86e-01	-0.063700	7.14e-01
SIGNALING BY PTK6	52	4.28e-01	0.063600	6.62e-01
HIV LIFE CYCLE	142	1.92e-01	-0.063500	4.21e-01
CALNEXIN CALRETICULIN CYCLE	26	5.79e-01	-0.062900	7.80e-01
HIV INFECTION	222	1.07e-01	-0.062800	2.99e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	5.73e-01	0.062600	7.76e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	22	6.12e-01	-0.062500	7.95e-01
SURFACTANT METABOLISM	16	6.67e-01	-0.062100	8.26e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	5.19e-01	-0.062100	7.36e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	282	7.33e-02	0.062100	2.30e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	27	5.80e-01	0.061500	7.81e-01
INTRAFLAGELLAR TRANSPORT	51	4.49e-01	-0.061300	6.84e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	224	1.15e-01	0.061300	3.15e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	32	5.50e-01	0.061100	7.61e-01
DNA REPLICATION PRE INITIATION	80	3.46e-01	-0.061000	5.93e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	4.90e-01	-0.060900	7.18e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	7.09e-01	0.059900	8.52e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	4.97e-01	0.059900	7.24e-01
SIGNALING BY INTERLEUKINS	353	5.41e-02	0.059800	1.93e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	84	3.46e-01	-0.059600	5.93e-01
INTERLEUKIN 37 SIGNALING	18	6.64e-01	0.059100	8.26e-01
FGFR2 LIGAND BINDING AND ACTIVATION	12	7.25e-01	0.058600	8.59e-01
GLUTATHIONE CONJUGATION	29	5.87e-01	-0.058300	7.85e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	6.96e-01	-0.058300	8.47e-01
INTERLEUKIN 2 FAMILY SIGNALING	33	5.62e-01	0.058300	7.67e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	6.97e-01	0.058100	8.47e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	22	6.38e-01	-0.057900	8.11e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	6.71e-01	0.057900	8.26e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	43	5.12e-01	-0.057800	7.34e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	6.72e-01	-0.057600	8.27e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	466	3.36e-02	0.057600	1.49e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	6.33e-01	0.057500	8.10e-01
DNA REPLICATION	122	2.73e-01	-0.057500	5.16e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	46	5.00e-01	0.057400	7.28e-01
RUNX2 REGULATES BONE DEVELOPMENT	28	6.03e-01	-0.056700	7.93e-01
SARS COV INFECTIONS	140	2.54e-01	-0.055900	4.95e-01
SIGNALING BY MET	75	4.04e-01	0.055800	6.40e-01
DAP12 INTERACTIONS	31	5.92e-01	-0.055600	7.89e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	7.00e-01	0.055600	8.50e-01
CELLULAR SENESCENCE	140	2.59e-01	-0.055300	5.03e-01
METABOLISM OF FAT SOLUBLE VITAMINS	33	5.83e-01	-0.055200	7.83e-01
INNATE IMMUNE SYSTEM	797	8.39e-03	0.055200	7.02e-02
DNA DOUBLE STRAND BREAK REPAIR	134	2.73e-01	-0.054900	5.16e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	75	4.13e-01	-0.054700	6.47e-01
TRIGLYCERIDE CATABOLISM	14	7.27e-01	-0.053900	8.60e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	5.15e-01	-0.053800	7.34e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	33	5.94e-01	-0.053700	7.89e-01
MAPK FAMILY SIGNALING CASCADES	287	1.20e-01	0.053400	3.22e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	6.58e-01	0.053400	8.21e-01
HEDGEHOG ON STATE	83	4.01e-01	-0.053300	6.40e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	6.80e-01	-0.053300	8.32e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	6.75e-01	-0.052900	8.29e-01
SIGNALING BY ERBB2	48	5.28e-01	-0.052700	7.44e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	6.69e-01	0.052600	8.26e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	11	7.64e-01	0.052400	8.77e-01
PCP CE PATHWAY	90	3.93e-01	-0.052100	6.31e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	85	4.08e-01	0.051900	6.43e-01
VISUAL PHOTOTRANSDUCTION	60	4.88e-01	-0.051800	7.15e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	6.08e-01	0.051600	7.94e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	7.22e-01	0.051500	8.59e-01
HYALURONAN UPTAKE AND DEGRADATION	12	7.58e-01	0.051300	8.76e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	57	5.03e-01	-0.051300	7.29e-01
ENOS ACTIVATION	11	7.69e-01	-0.051100	8.80e-01
MUSCLE CONTRACTION	159	2.67e-01	0.051100	5.12e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	36	5.98e-01	0.050800	7.92e-01
SIGNALING BY EGFR	47	5.49e-01	-0.050500	7.61e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	7.44e-01	0.050500	8.68e-01
PLASMA LIPOPROTEIN ASSEMBLY	12	7.63e-01	0.050400	8.77e-01
HEDGEHOG OFF STATE	107	3.71e-01	-0.050100	6.15e-01
PROTEIN LOCALIZATION	159	2.76e-01	0.050100	5.20e-01
MAP2K AND MAPK ACTIVATION	36	6.03e-01	0.050100	7.93e-01
SENSORY PERCEPTION	148	2.94e-01	-0.050000	5.42e-01
SIGNALING BY NTRK2 TRKB	25	6.66e-01	0.049900	8.26e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	4.34e-01	-0.049700	6.68e-01
TRANSLESION SYNTHESIS BY POLH	19	7.08e-01	-0.049700	8.52e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	7.09e-01	0.049500	8.52e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	6.40e-01	-0.049400	8.11e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	7.58e-01	-0.049400	8.76e-01
PROCESSING AND ACTIVATION OF SUMO	10	7.87e-01	0.049400	8.88e-01
INWARDLY RECTIFYING K CHANNELS	32	6.29e-01	0.049400	8.06e-01
HOST INTERACTIONS OF HIV FACTORS	126	3.39e-01	-0.049300	5.90e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	7.42e-01	0.049000	8.68e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	61	5.11e-01	-0.048700	7.34e-01
SIGNALING BY FGFR4	31	6.39e-01	0.048700	8.11e-01
SNRNP ASSEMBLY	51	5.48e-01	-0.048600	7.61e-01
CA2 PATHWAY	58	5.25e-01	0.048200	7.42e-01
GROWTH HORMONE RECEPTOR SIGNALING	21	7.02e-01	-0.048200	8.50e-01
MITOCHONDRIAL PROTEIN IMPORT	63	5.09e-01	-0.048200	7.33e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	25	6.78e-01	0.048000	8.31e-01
DUAL INCISION IN TC NER	64	5.11e-01	-0.047500	7.34e-01
DSCAM INTERACTIONS	11	7.86e-01	-0.047300	8.88e-01
BIOLOGICAL OXIDATIONS	128	3.58e-01	0.047100	6.04e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	61	5.28e-01	0.046700	7.44e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	6.84e-01	0.046200	8.36e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	5.60e-01	-0.045400	7.65e-01
PRE NOTCH EXPRESSION AND PROCESSING	62	5.37e-01	-0.045300	7.53e-01
FOXO MEDIATED TRANSCRIPTION	59	5.47e-01	0.045300	7.61e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	6.53e-01	0.045200	8.21e-01
PYRIMIDINE CATABOLISM	10	8.05e-01	0.045100	9.01e-01
G ALPHA Z SIGNALLING EVENTS	45	6.02e-01	-0.044900	7.93e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	7.79e-01	0.044900	8.88e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	7.42e-01	0.044800	8.68e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	6.27e-01	-0.044400	8.06e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	38	6.36e-01	-0.044400	8.11e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	6.86e-01	0.044100	8.38e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	7.14e-01	0.044100	8.54e-01
HCMV LATE EVENTS	64	5.43e-01	0.044000	7.61e-01
CHOLESTEROL BIOSYNTHESIS	24	7.10e-01	-0.043800	8.52e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	7.20e-01	-0.043100	8.59e-01
NEUTROPHIL DEGRANULATION	397	1.45e-01	0.042700	3.62e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	7.44e-01	-0.042100	8.68e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	6.29e-01	-0.042100	8.06e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	28	7.02e-01	0.041800	8.50e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	7.41e-01	0.041700	8.68e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	55	5.93e-01	0.041600	7.89e-01
MISMATCH REPAIR	14	7.88e-01	0.041600	8.88e-01
TIE2 SIGNALING	17	7.69e-01	0.041100	8.80e-01
ANCHORING FIBRIL FORMATION	15	7.84e-01	0.040800	8.88e-01
RETINOID CYCLE DISEASE EVENTS	10	8.23e-01	-0.040800	9.09e-01
SIGNALING BY FGFR1	43	6.44e-01	0.040700	8.15e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	8.24e-01	0.040500	9.09e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	50	6.21e-01	0.040400	8.01e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	178	3.54e-01	-0.040300	6.01e-01
METALLOPROTEASE DUBS	26	7.23e-01	-0.040200	8.59e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	7.69e-01	-0.039900	8.80e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	7.82e-01	0.039900	8.88e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	7.58e-01	-0.039800	8.76e-01
ACYL CHAIN REMODELLING OF PG	11	8.19e-01	0.039800	9.09e-01
SIGNALING BY NUCLEAR RECEPTORS	225	3.04e-01	-0.039800	5.51e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	98	4.96e-01	0.039800	7.24e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	7.59e-01	-0.039600	8.77e-01
RHOQ GTPASE CYCLE	58	6.06e-01	0.039200	7.94e-01
PECAM1 INTERACTIONS	12	8.15e-01	0.039000	9.09e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	7.48e-01	0.038800	8.71e-01
SIGNALING BY HEDGEHOG	142	4.27e-01	-0.038600	6.62e-01
SIGNALING BY GPCR	494	1.44e-01	0.038500	3.61e-01
CILIUM ASSEMBLY	192	3.59e-01	-0.038400	6.05e-01
LAGGING STRAND SYNTHESIS	20	7.66e-01	-0.038400	8.79e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	7.55e-01	0.038400	8.76e-01
SARS COV 1 INFECTION	48	6.46e-01	0.038400	8.16e-01
NGF STIMULATED TRANSCRIPTION	36	6.91e-01	-0.038300	8.42e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS	11	8.27e-01	0.038000	9.09e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	90	5.34e-01	0.038000	7.50e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	7.87e-01	-0.037900	8.88e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	5.49e-01	-0.037900	7.61e-01
SYNDECAN INTERACTIONS	26	7.38e-01	-0.037900	8.68e-01
KINESINS	48	6.50e-01	0.037800	8.20e-01
CHROMATIN MODIFYING ENZYMES	218	3.37e-01	-0.037800	5.88e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	8.36e-01	0.037800	9.11e-01
SIGNALING BY FGFR3	34	7.03e-01	0.037800	8.50e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	6.62e-01	0.037700	8.24e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	6.69e-01	0.037700	8.26e-01
M PHASE	343	2.33e-01	0.037500	4.70e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	5.73e-01	-0.037200	7.76e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	7.44e-01	-0.037000	8.68e-01
CELL CYCLE MITOTIC	478	1.69e-01	0.036900	3.90e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	6.69e-01	0.036800	8.26e-01
REGULATION OF TP53 ACTIVITY	154	4.31e-01	0.036800	6.65e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	7.73e-01	0.036400	8.84e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	12	8.28e-01	-0.036200	9.09e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	7.11e-01	-0.036200	8.52e-01
PI 3K CASCADE FGFR2	16	8.03e-01	0.036000	9.00e-01
RHOD GTPASE CYCLE	51	6.57e-01	0.035900	8.21e-01
LAMININ INTERACTIONS	29	7.38e-01	-0.035900	8.68e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	285	3.05e-01	-0.035400	5.51e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	8.48e-01	-0.035100	9.17e-01
SIGNALING BY FGFR1 IN DISEASE	32	7.32e-01	0.035000	8.64e-01
IRE1ALPHA ACTIVATES CHAPERONES	50	6.69e-01	0.034900	8.26e-01
HATS ACETYLATE HISTONES	92	5.64e-01	-0.034800	7.67e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	8.16e-01	0.034700	9.09e-01
RUNX3 REGULATES NOTCH SIGNALING	13	8.29e-01	0.034500	9.09e-01
SIGNALING BY CSF3 G CSF	29	7.51e-01	0.034100	8.73e-01
EPHRIN SIGNALING	19	7.98e-01	0.034000	8.97e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	8.47e-01	0.033600	9.17e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	7.40e-01	-0.033400	8.68e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	8.42e-01	-0.033200	9.16e-01
RND1 GTPASE CYCLE	39	7.22e-01	0.032900	8.59e-01
PHASE II CONJUGATION OF COMPOUNDS	63	6.54e-01	0.032700	8.21e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	74	6.27e-01	0.032700	8.06e-01
TP53 REGULATES METABOLIC GENES	87	6.00e-01	-0.032600	7.92e-01
LEISHMANIA INFECTION	204	4.24e-01	0.032500	6.59e-01
DNA REPAIR	290	3.45e-01	-0.032300	5.93e-01
G ALPHA S SIGNALLING EVENTS	110	5.64e-01	-0.031900	7.67e-01
NICOTINATE METABOLISM	25	7.84e-01	0.031600	8.88e-01
SUPPRESSION OF PHAGOSOMAL MATURATION	13	8.44e-01	-0.031500	9.16e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	7.95e-01	-0.031300	8.95e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	7.60e-01	-0.031200	8.77e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	39	7.37e-01	-0.031100	8.68e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	7.62e-01	0.030900	8.77e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	7.04e-01	0.030500	8.50e-01
EPH EPHRIN SIGNALING	91	6.21e-01	-0.030000	8.01e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	8.28e-01	0.029600	9.09e-01
N GLYCAN ANTENNAE ELONGATION	15	8.44e-01	0.029400	9.16e-01
REGULATION OF PTEN GENE TRANSCRIPTION	59	7.03e-01	-0.028700	8.50e-01
MITOCHONDRIAL BIOGENESIS	93	6.37e-01	-0.028300	8.11e-01
INTERLEUKIN 10 SIGNALING	21	8.23e-01	0.028200	9.09e-01
SIGNALING BY PDGF	57	7.17e-01	0.027800	8.56e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	7.57e-01	-0.027200	8.76e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	364	3.76e-01	0.027100	6.18e-01
REGULATION OF TNFR1 SIGNALING	34	7.86e-01	-0.026900	8.88e-01
RHOH GTPASE CYCLE	37	7.79e-01	-0.026700	8.88e-01
REGULATED PROTEOLYSIS OF P75NTR	12	8.74e-01	0.026500	9.38e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	22	8.31e-01	-0.026300	9.09e-01
SPRY REGULATION OF FGF SIGNALING	16	8.56e-01	0.026200	9.25e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	7.29e-01	-0.026100	8.61e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	11	8.81e-01	-0.026100	9.43e-01
RNA POLYMERASE II TRANSCRIPTION	1101	1.48e-01	-0.026000	3.64e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	23	8.29e-01	0.025900	9.09e-01
DAP12 SIGNALING	24	8.27e-01	-0.025700	9.09e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	8.09e-01	0.025400	9.05e-01
OVARIAN TUMOR DOMAIN PROTEASES	37	7.89e-01	-0.025400	8.90e-01
ACYL CHAIN REMODELLING OF PS	15	8.66e-01	-0.025300	9.30e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	8.31e-01	-0.025200	9.09e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	59	7.40e-01	-0.025000	8.68e-01
NUCLEOTIDE EXCISION REPAIR	109	6.56e-01	-0.024700	8.21e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	28	8.23e-01	0.024400	9.09e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	140	6.19e-01	-0.024400	8.01e-01
ECM PROTEOGLYCANS	67	7.32e-01	-0.024200	8.64e-01
ACYL CHAIN REMODELLING OF PC	17	8.63e-01	-0.024100	9.29e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	8.22e-01	0.023800	9.09e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	74	7.25e-01	0.023700	8.59e-01
FC EPSILON RECEPTOR FCERI SIGNALING	125	6.52e-01	0.023400	8.20e-01
SELECTIVE AUTOPHAGY	72	7.33e-01	-0.023300	8.64e-01
GABA B RECEPTOR ACTIVATION	40	8.03e-01	0.022900	9.00e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	8.88e-01	-0.022600	9.45e-01
RA BIOSYNTHESIS PATHWAY	14	8.84e-01	-0.022600	9.43e-01
SIGNAL TRANSDUCTION BY L1	21	8.65e-01	0.021400	9.30e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	13	8.94e-01	0.021400	9.49e-01
RESOLUTION OF D LOOP STRUCTURES	30	8.43e-01	-0.020900	9.16e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	8.97e-01	0.020800	9.51e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	8.61e-01	-0.020700	9.28e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	9.06e-01	0.020500	9.53e-01
FANCONI ANEMIA PATHWAY	37	8.32e-01	0.020100	9.09e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	7.64e-01	0.019600	8.77e-01
TNF SIGNALING	43	8.24e-01	-0.019600	9.09e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	11	9.11e-01	0.019500	9.55e-01
DNA DAMAGE RECOGNITION IN GG NER	38	8.36e-01	0.019500	9.11e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	94	7.49e-01	-0.019100	8.71e-01
TRANSCRIPTIONAL REGULATION BY MECP2	60	8.03e-01	0.018700	9.00e-01
HCMV EARLY EVENTS	79	7.82e-01	-0.018100	8.88e-01
G PROTEIN BETA GAMMA SIGNALLING	31	8.63e-01	-0.017900	9.29e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	8.90e-01	-0.017900	9.47e-01
DEUBIQUITINATION	242	6.44e-01	0.017300	8.15e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	9.08e-01	-0.017200	9.53e-01
VIRAL MESSENGER RNA SYNTHESIS	42	8.48e-01	-0.017100	9.17e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	146	7.24e-01	0.016900	8.59e-01
KILLING MECHANISMS	10	9.31e-01	0.015800	9.67e-01
MITOTIC G2 G2 M PHASES	186	7.11e-01	-0.015800	8.52e-01
PEPTIDE HORMONE METABOLISM	63	8.30e-01	-0.015600	9.09e-01
MITOTIC METAPHASE AND ANAPHASE	211	6.97e-01	0.015600	8.47e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	8.85e-01	-0.015500	9.43e-01
REGULATION OF INSULIN SECRETION	72	8.20e-01	0.015500	9.09e-01
SARS COV 2 INFECTION	65	8.32e-01	0.015200	9.09e-01
ER QUALITY CONTROL COMPARTMENT ERQC	21	9.04e-01	-0.015200	9.53e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	9.29e-01	-0.014900	9.66e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	9.26e-01	0.014900	9.66e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	9.32e-01	-0.014800	9.67e-01
INTERLEUKIN 1 SIGNALING	96	8.03e-01	-0.014800	9.00e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	9.12e-01	0.014700	9.56e-01
G ALPHA I SIGNALLING EVENTS	204	7.21e-01	0.014500	8.59e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	18	9.16e-01	-0.014400	9.59e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	54	8.57e-01	-0.014200	9.25e-01
DEADENYLATION OF MRNA	25	9.04e-01	0.014000	9.53e-01
ERBB2 REGULATES CELL MOTILITY	14	9.29e-01	0.013700	9.66e-01
MET PROMOTES CELL MOTILITY	39	8.84e-01	0.013500	9.43e-01
UNFOLDED PROTEIN RESPONSE UPR	85	8.31e-01	0.013400	9.09e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	142	7.85e-01	0.013300	8.88e-01
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	9.42e-01	-0.013200	9.73e-01
MITOTIC TELOPHASE CYTOKINESIS	13	9.34e-01	0.013200	9.67e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	9.03e-01	0.012800	9.53e-01
FORMATION OF THE CORNIFIED ENVELOPE	27	9.08e-01	0.012800	9.53e-01
KERATINIZATION	27	9.08e-01	0.012800	9.53e-01
C TYPE LECTIN RECEPTORS CLRS	114	8.14e-01	-0.012800	9.09e-01
APOPTOSIS	165	7.82e-01	0.012500	8.88e-01
NOD1 2 SIGNALING PATHWAY	36	8.97e-01	0.012500	9.51e-01
UB SPECIFIC PROCESSING PROTEASES	167	7.82e-01	-0.012400	8.88e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	9.00e-01	-0.012400	9.52e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	9.28e-01	0.012300	9.66e-01
HYALURONAN METABOLISM	16	9.33e-01	0.012200	9.67e-01
SIGNALING BY THE B CELL RECEPTOR BCR	105	8.32e-01	-0.012000	9.09e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	126	8.19e-01	-0.011800	9.09e-01
CELL CYCLE CHECKPOINTS	245	7.58e-01	-0.011400	8.76e-01
TRNA PROCESSING IN THE NUCLEUS	56	8.83e-01	-0.011300	9.43e-01
BASIGIN INTERACTIONS	22	9.29e-01	0.010900	9.66e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	9.33e-01	-0.010800	9.67e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	14	9.44e-01	0.010800	9.73e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	554	6.68e-01	0.010700	8.26e-01
INTERLEUKIN 1 FAMILY SIGNALING	123	8.45e-01	0.010200	9.16e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	9.40e-01	-0.009910	9.72e-01
ACTIVATION OF RAC1	13	9.52e-01	0.009700	9.78e-01
SIGNALING BY TGFB FAMILY MEMBERS	97	8.78e-01	-0.009000	9.40e-01
TRNA PROCESSING	105	8.76e-01	-0.008790	9.39e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	9.38e-01	-0.008690	9.70e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	9.43e-01	-0.008620	9.73e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	9.54e-01	-0.008550	9.79e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	9.61e-01	-0.008420	9.81e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	8.98e-01	-0.008130	9.51e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	9.21e-01	0.007850	9.64e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	108	8.93e-01	0.007470	9.49e-01
TELOMERE C STRAND SYNTHESIS INITIATION	13	9.64e-01	-0.007220	9.82e-01
SUMOYLATION	164	8.76e-01	-0.007070	9.39e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	109	9.01e-01	0.006910	9.52e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	21	9.57e-01	0.006860	9.79e-01
TRANSCRIPTIONAL REGULATION BY TP53	346	8.32e-01	0.006660	9.09e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	9.62e-01	0.006400	9.82e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	25	9.57e-01	-0.006200	9.79e-01
GAP JUNCTION ASSEMBLY	21	9.61e-01	-0.006200	9.81e-01
METABOLISM OF FOLATE AND PTERINES	15	9.69e-01	-0.005880	9.85e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	97	9.24e-01	-0.005630	9.65e-01
SEPARATION OF SISTER CHROMATIDS	170	9.01e-01	-0.005560	9.52e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	9.76e-01	-0.005290	9.88e-01
AQUAPORIN MEDIATED TRANSPORT	41	9.54e-01	0.005210	9.79e-01
RNA POLYMERASE III TRANSCRIPTION	41	9.58e-01	0.004800	9.79e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	9.65e-01	-0.004750	9.83e-01
PHOSPHORYLATION OF THE APC C	18	9.73e-01	0.004620	9.87e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	9.49e-01	-0.004350	9.77e-01
PROGRAMMED CELL DEATH	187	9.23e-01	0.004110	9.64e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	9.77e-01	-0.003980	9.88e-01
MITOPHAGY	29	9.71e-01	-0.003840	9.87e-01
MET ACTIVATES RAP1 AND RAC1	10	9.84e-01	-0.003690	9.95e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	106	9.51e-01	0.003440	9.78e-01
RHOV GTPASE CYCLE	33	9.73e-01	0.003380	9.87e-01
CLEC7A DECTIN 1 SIGNALING	94	9.55e-01	0.003330	9.79e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	9.86e-01	-0.002270	9.96e-01
SIGNALING BY WNT	269	9.70e-01	-0.001350	9.86e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	35	9.91e-01	-0.001080	9.98e-01
LGI ADAM INTERACTIONS	14	9.95e-01	-0.000991	9.98e-01
G ALPHA Q SIGNALLING EVENTS	163	9.88e-01	0.000662	9.98e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	20	9.97e-01	0.000538	9.98e-01
S PHASE	154	9.92e-01	-0.000473	9.98e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	9.95e-01	0.000445	9.98e-01
HCMV INFECTION	102	9.94e-01	-0.000433	9.98e-01
DNA DAMAGE BYPASS	46	9.96e-01	-0.000380	9.98e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	22	9.98e-01	-0.000368	9.98e-01
REPRESSION OF WNT TARGET GENES	14	9.98e-01	-0.000363	9.98e-01
CELL CYCLE	595	9.90e-01	-0.000308	9.98e-01
EXTRACELLULAR MATRIX ORGANIZATION	248	9.97e-01	0.000149	9.98e-01

Detailed Gene set reports

EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
	306
set	EUKARYOTIC TRANSLATION ELONGATION
setSize	88
pANOVA	5.9e-27
s.dist	-0.662
p.adjustANOVA	3.48e-24

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Rps26	-6585
Rpl29	-6490
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Eef1b2	-5432
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Eef1g	-4967
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Rps3a1	-4631
Rpl6	-4589
Rpl7	-4400
Rps13	-4263
Rpl27	-4253
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Rps14	-3804
Rpsa	-3236
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Eef1a1	-1720
Rps3	-1626
Eef1d	-1347
Rpl3l	-1143
Rpl5	46
Rplp0	1020
Rpl10	1911
Eef2	5948
Eef1a2	7108

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
	840
set	RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize	96
pANOVA	1.03e-27
s.dist	-0.644
p.adjustANOVA	1.21e-24

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Ddit3	-8171
Rpl39	-8168
Atf3	-8143
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Ddit3	-8171
Rpl39	-8168
Atf3	-8143
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Rps26	-6585
Rpl29	-6490
Cebpg	-6486
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Eif2s2	-6239
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Impact	-4689
Rps3a1	-4631
Rpl6	-4589
Rpl7	-4400
Trib3	-4351
Rps13	-4263
Rpl27	-4253
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Rps14	-3804
Rpsa	-3236
Atf4	-3007
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Eif2ak4	-2710
Rps3	-1626
Rpl3l	-1143
Rpl5	46
Rplp0	1020
Cebpb	1381
Eif2s3x	1484
Rpl10	1911
Gcn1	2185
Eif2s1	3113
Asns	3915
Atf2	4373

SCAVENGING OF HEME FROM PLASMA

SCAVENGING OF HEME FROM PLASMA
	911
set	SCAVENGING OF HEME FROM PLASMA
setSize	12
pANOVA	0.000204
s.dist	0.619
p.adjustANOVA	0.00438

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Jchain	8958
Igkv19-93	8911
Cd163	8808
Hbb-bt	8655
Hba-a1	8646
Hba-a2	8344
Hp	7261
Apol8	5812
Apol9a	5786
Lrp1	5640
Apol7e	-1421
Apol10b	-6531

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Jchain	8958
Igkv19-93	8911
Cd163	8808
Hbb-bt	8655
Hba-a1	8646
Hba-a2	8344
Hp	7261
Apol8	5812
Apol9a	5786
Lrp1	5640
Apol7e	-1421
Apol10b	-6531

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
	1014
set	SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize	107
pANOVA	1.56e-26
s.dist	-0.596
p.adjustANOVA	6.15e-24

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Sec61b	-7445
Rps17	-7426

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Sec61b	-7445
Rps17	-7426
Rps8	-7421
Rpn1	-7356
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Rps26	-6585
Rpl29	-6490
Srp19	-6412
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Sec11c	-5958
Srp14	-5955
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Rpl12	-5252
Ddost	-5204
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Spcs1	-5121
Rps5	-4990
Rps9	-4981
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Rps3a1	-4631
Rpl6	-4589
Spcs2	-4537
Rpl7	-4400
Rps13	-4263
Rpl27	-4253
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Rps14	-3804
Sec11a	-3700
Rpsa	-3236
Ssr4	-3161
Tram1	-3121
Srprb	-3076
Srp54a	-2925
Rpl7a	-2903
Rpn2	-2862
Rpl9	-2750
Rps10	-2748
Sec61a1	-2532
Srp9	-1958
Sec61a2	-1704
Rps3	-1626
Rpl3l	-1143
Ssr2	-308
Rpl5	46
Rplp0	1020
Ssr1	1403
Srp72	1685
Rpl10	1911
Sec61g	3698
Ssr3	4236
Srp68	7243
Srpr	7427
Spcs3	7852

ABC TRANSPORTERS IN LIPID HOMEOSTASIS

ABC TRANSPORTERS IN LIPID HOMEOSTASIS
	4
set	ABC TRANSPORTERS IN LIPID HOMEOSTASIS
setSize	13
pANOVA	0.000333
s.dist	0.575
p.adjustANOVA	0.00666

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Abca2	8768
Abca9	8688
Pex19	8280
Abca5	8188
Abcd3	7544
Abcg4	7379
Abca3	7024
Abca6	6191
Pex3	3435
Abca7	3202
Abcd2	3176
Abcd1	1839
Abcg1	-4111

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Abca2	8768
Abca9	8688
Pex19	8280
Abca5	8188
Abcd3	7544
Abcg4	7379
Abca3	7024
Abca6	6191
Pex3	3435
Abca7	3202
Abcd2	3176
Abcd1	1839
Abcg1	-4111

ATTENUATION PHASE

ATTENUATION PHASE
	85
set	ATTENUATION PHASE
setSize	25
pANOVA	1.25e-06
s.dist	-0.56
p.adjustANOVA	4.63e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Serpinh1	-8229
Hspb1	-7873
Crebbp	-7594
Hspa1b	-7483
Hsph1	-7270
Fkbp4	-7157
Hspa1a	-7112
Hsp90ab1	-7101
Hspa8	-6967
Hspa1l	-6846
Hsf1	-6826
Hsp90aa1	-6761
Ptges3	-6622
Dnajb1	-6438
Ubb	-5788
Hsbp1	-4782
Dnajb6	-4079
Hspa2	-3690
Mrpl18	-3308
Rln1	-2003

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Serpinh1	-8229
Hspb1	-7873
Crebbp	-7594
Hspa1b	-7483
Hsph1	-7270
Fkbp4	-7157
Hspa1a	-7112
Hsp90ab1	-7101
Hspa8	-6967
Hspa1l	-6846
Hsf1	-6826
Hsp90aa1	-6761
Ptges3	-6622
Dnajb1	-6438
Ubb	-5788
Hsbp1	-4782
Dnajb6	-4079
Hspa2	-3690
Mrpl18	-3308
Rln1	-2003
Hspb2	-1870
Col4a6	2570
Dedd2	3130
Tnfrsf21	4245
Ep300	4337

NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD
	633
set	NONSENSE MEDIATED DECAY NMD
setSize	110
pANOVA	4.85e-24
s.dist	-0.558
p.adjustANOVA	1.15e-21

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Upf3b	-8113
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rbm8a	-7850
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Upf3b	-8113
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rbm8a	-7850
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Magohb	-6884
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Upf3a	-6603
Rps26	-6585
Rpl29	-6490
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Rpl22l1	-6218
Ncbp2	-6200
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Eif4a3	-5319
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Magoh	-5137
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Rps3a1	-4631
Rpl6	-4589
Rpl7	-4400
Upf2	-4384
Rps13	-4263
Rpl27	-4253
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Rps14	-3804
Rpsa	-3236
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Rnps1	-2675
Ppp2r2a	-2550
Smg8	-2382
Gspt2	-1659
Rps3	-1626
Rpl3l	-1143
Smg6	-734
Pabpc1	-661
Rpl5	46
Smg1	348
Smg9	362
Casc3	400
Etf1	798
Rplp0	1020
Ppp2ca	1295
Rpl10	1911
Smg7	2446
Pnrc2	2489
Ncbp1	2649
Upf1	2843
Eif4g1	3132
Ppp2r1a	3759
Gspt1	6993
Dcp1a	7256
Smg5	8627

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
	1050
set	SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
setSize	11
pANOVA	0.00158
s.dist	0.55
p.adjustANOVA	0.0219

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fig4	8626
Mtmr2	8484
Pik3c2a	8120
Pik3c3	7990
Vac14	7547
Mtmr7	7420
Mtmr4	4004
Mtmr9	2229
Pik3r4	1359
Pikfyve	957
Mtm1	-162

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fig4	8626
Mtmr2	8484
Pik3c2a	8120
Pik3c3	7990
Vac14	7547
Mtmr7	7420
Mtmr4	4004
Mtmr9	2229
Pik3r4	1359
Pikfyve	957
Mtm1	-162

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
	816
set	REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize	15
pANOVA	0.000437
s.dist	0.524
p.adjustANOVA	0.0082

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdk2	8742
Pdk4	8402
Pdp2	7654
Pdhx	7495
Rxra	7400
Pdha1	7131
Pdpr	6952
Dld	6763
Ppard	5492
Dlat	5225
Pdp1	3897
Pdk3	3631
Pdhb	1032
Pdk1	-2709
Gstz1	-3337

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdk2	8742
Pdk4	8402
Pdp2	7654
Pdhx	7495
Rxra	7400
Pdha1	7131
Pdpr	6952
Dld	6763
Ppard	5492
Dlat	5225
Pdp1	3897
Pdk3	3631
Pdhb	1032
Pdk1	-2709
Gstz1	-3337

SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM
	915
set	SELENOAMINO ACID METABOLISM
setSize	110
pANOVA	1.46e-20
s.dist	-0.513
p.adjustANOVA	2.46e-18

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Inmt	-6902
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Rps26	-6585
Rpl29	-6490
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Gsr	-4921
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Mars1	-4676
Rps3a1	-4631
Rpl6	-4589
Rpl7	-4400
Rps13	-4263
Rpl27	-4253
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Rps14	-3804
Aimp1	-3686
Ahcy	-3269
Rpsa	-3236
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Eefsec	-2523
Gnmt	-2343
Eef1e1	-2291
Hnmt	-1900
Rps3	-1626
Sepsecs	-1591
Aimp2	-1550
Rpl3l	-1143
Eprs	-776
Rpl5	46
Secisbp2	416
Sars	764
Papss2	955
Rplp0	1020
Papss1	1201
Txnrd1	1562
Rpl10	1911
Lars	1955
Pstk	2258
Rars	3683
Kars	3789
Dars	5055
Qars	5563
Cbs	6322
Iars	6415
Cth	6451
Scly	7332
Sephs2	7463

EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION
	307
set	EUKARYOTIC TRANSLATION INITIATION
setSize	115
pANOVA	1.57e-19
s.dist	-0.488
p.adjustANOVA	2.06e-17

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Eif3a	-8016
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Eif5b	-7783
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Eif3a	-8016
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Eif5b	-7783
Rps23	-7780
Rpl36al	-7752
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Eif4a1	-6776
Rps26	-6585
Rpl29	-6490
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Eif2s2	-6239
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Rps3a1	-4631
Rpl6	-4589
Rpl7	-4400
Rps13	-4263
Rpl27	-4253
Eif2b3	-4092
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Eif3j1	-3873
Rps14	-3804
Eif3g	-3606
Rpsa	-3236
Eif3k	-2953
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Eif3e	-2360
Rps3	-1626
Rpl3l	-1143
Eif3j2	-684
Pabpc1	-661
Eif3c	-650
Eif4ebp1	-225
Rpl5	46
Eif3h	427
Rplp0	1020
Eif3b	1202
Eif3l	1373
Eif2s3x	1484
Eif3f	1775
Eif3i	1893
Rpl10	1911
Eif4e	2249
Eif2b4	2377
Eif3m	2474
Eif2s1	3113
Eif4g1	3132
Eif4b	3480
Eif3d	3617
Eif2b1	5454
Eif4h	5491
Eif2b5	6573
Eif4a2	6904
Eif5	7801
Eif1ax	7855
Eif2b2	8705

SEROTONIN RECEPTORS

SEROTONIN RECEPTORS
	927
set	SEROTONIN RECEPTORS
setSize	10
pANOVA	0.00862
s.dist	0.48
p.adjustANOVA	0.0714

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Htr5a	8755
Htr2a	8433
Htr1f	7705
Htr4	7296
Htr2c	6329
Htr7	5082
Htr6	3581
Htr1b	1500
Htr1a	-478
Htr1d	-2876

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Htr5a	8755
Htr2a	8433
Htr1f	7705
Htr4	7296
Htr2c	6329
Htr7	5082
Htr6	3581
Htr1b	1500
Htr1a	-478
Htr1d	-2876

ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
	74
set	ASPARTATE AND ASPARAGINE METABOLISM
setSize	11
pANOVA	0.00619
s.dist	0.477
p.adjustANOVA	0.0575

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Slc25a13	8974
Folh1	8959
Slc25a12	6820
Nat8l	6436
Got2	6181
Got1	5307
Gadl1	5160
Asns	3915
Aspa	1180
Aspg	1145
Naalad2	-4506

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Slc25a13	8974
Folh1	8959
Slc25a12	6820
Nat8l	6436
Got2	6181
Got1	5307
Gadl1	5160
Asns	3915
Aspa	1180
Aspg	1145
Naalad2	-4506

LYSOSPHINGOLIPID AND LPA RECEPTORS

LYSOSPHINGOLIPID AND LPA RECEPTORS
	524
set	LYSOSPHINGOLIPID AND LPA RECEPTORS
setSize	13
pANOVA	0.00316
s.dist	-0.473
p.adjustANOVA	0.0352

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Plppr1	-7743
S1pr2	-7701
Lpar2	-6582
Plppr3	-6176
S1pr4	-6154
S1pr3	-5550
Plppr5	-5179
S1pr1	-5091
Lpar1	-3761
Plppr4	-3509
Plppr2	-2302
S1pr5	5007
Lpar3	6507

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Plppr1	-7743
S1pr2	-7701
Lpar2	-6582
Plppr3	-6176
S1pr4	-6154
S1pr3	-5550
Plppr5	-5179
S1pr1	-5091
Lpar1	-3761
Plppr4	-3509
Plppr2	-2302
S1pr5	5007
Lpar3	6507

SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL

SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL
	1042
set	SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL
setSize	13
pANOVA	0.0041
s.dist	0.46
p.adjustANOVA	0.0429

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Inpp5j	8635
Impa1	8633
Inpp4b	7886
Impa2	7832
Mtmr7	7420
Inpp5b	6351
Synj1	4694
Inpp5a	4093
Mtmr9	2229
Inpp1	1389
Inpp4a	464
Ocrl	-20
Isyna1	-2938

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Inpp5j	8635
Impa1	8633
Inpp4b	7886
Impa2	7832
Mtmr7	7420
Inpp5b	6351
Synj1	4694
Inpp5a	4093
Mtmr9	2229
Inpp1	1389
Inpp4a	464
Ocrl	-20
Isyna1	-2938

CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION

CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION
	162
set	CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION
setSize	11
pANOVA	0.0107
s.dist	0.444
p.adjustANOVA	0.0786

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Itpr3	8936
Itpr1	7850
Ahcyl1	7319
Ppp3cb	6940
Itpr2	5765
Ppp3r1	5746
Calm1	5178
Nfatc2	1843
Ppp3ca	1306
Nfatc1	-37
Nfatc3	-4352

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Itpr3	8936
Itpr1	7850
Ahcyl1	7319
Ppp3cb	6940
Itpr2	5765
Ppp3r1	5746
Calm1	5178
Nfatc2	1843
Ppp3ca	1306
Nfatc1	-37
Nfatc3	-4352

REGULATION OF EXPRESSION OF SLITS AND ROBOS

REGULATION OF EXPRESSION OF SLITS AND ROBOS
	793
set	REGULATION OF EXPRESSION OF SLITS AND ROBOS
setSize	165
pANOVA	1.14e-22
s.dist	-0.442
p.adjustANOVA	2.25e-20

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Upf3b	-8113
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Psmb8	-7892
Rbm8a	-7850
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Elob	-7700
Rpl35	-7645
Rpl36a	-7632

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Upf3b	-8113
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Rps21	-7927
Psmb8	-7892
Rbm8a	-7850
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Elob	-7700
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Sem1	-7343
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Magohb	-6884
Rpl10a	-6880
Rpl36	-6858
Psmb9	-6811
Rpl14	-6787
Psme2	-6785
Psme1	-6705
Upf3a	-6603
Rps26	-6585
Rpl29	-6490
Rps7	-6355
Rplp2	-6350
Msi1	-6334
Rps19	-6333
Rpl22l1	-6218
Ncbp2	-6200
Rpl34	-6199
Uba52	-6187
Psma4	-6171
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Rps6	-5794
Ubb	-5788
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Ldb1	-5677
Isl1	-5637
Rpl11	-5571
Rps24	-5471
Eif4a3	-5319
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Psmb10	-5152
Magoh	-5137
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Psmb6	-4652
Rps3a1	-4631
Rpl6	-4589
Psma8	-4476
Psma3	-4401
Rpl7	-4400
Upf2	-4384
Lhx9	-4354
Rbx1	-4331
Rps13	-4263
Rpl27	-4253
Psmb4	-4169
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Rps14	-3804
Psmc5	-3574
Psmd13	-3352
Psmd11	-3256
Rpsa	-3236
Psmd7	-3146
Psmc1	-3062
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Rnps1	-2675
Lhx2	-2612
Psmd9	-2560
Col4a5	-2478
Psmb1	-2233
Psmc4	-2148
Psmd3	-1976
Psmc3	-1856
Gspt2	-1659
Rps3	-1626
Ubc	-1603
Psmb7	-1198
Rpl3l	-1143
Psmd12	-1084
Psmd8	-1009
Psmd4	-969
Pabpc1	-661
Psmb5	-557
Robo3	-169
Psmb3	-84
Psmc2	16
Rpl5	46
Slit1	133
Eloc	206
Zswim8	309
Casc3	400
Psma7	610
Etf1	798
Psmb2	889
Psma6	894
Rplp0	1020
Psmd10	1582
Psmd14	1588
Lhx4	1605
Psmd1	1846
Rpl10	1911
Psmd6	1924
Psma1	1971
Psma2	1978
Cul2	2148
Psma5	2437
Hoxa2	2555
Ncbp1	2649
Psmc6	2951
Eif4g1	3132
Slit2	3755
Lhx3	3993
Dag1	4358
Psme4	4502
Psmd2	4620
Robo1	6486
Psmf1	6964
Gspt1	6993
Psme3	7033
Usp33	7314
Robo2	7751
Psmd5	7993

BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM
	105
set	BRANCHED CHAIN AMINO ACID CATABOLISM
setSize	21
pANOVA	0.00048
s.dist	0.44
p.adjustANOVA	0.00873

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aldh6a1	8794
Slc25a44	8203
Ppm1k	8025
Bcat1	7988
Bckdk	6956
Bckdhb	6910
Dld	6763
Dbt	6310
Hsd17b10	5880
Echs1	5761
Acadsb	5337
Bckdha	5080
Hibadh	4306
Auh	3614
Mccc1	3231
Acat1	1915
Acad8	284
Ivd	-1246
Bcat2	-1263
Hibch	-1534

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aldh6a1	8794
Slc25a44	8203
Ppm1k	8025
Bcat1	7988
Bckdk	6956
Bckdhb	6910
Dld	6763
Dbt	6310
Hsd17b10	5880
Echs1	5761
Acadsb	5337
Bckdha	5080
Hibadh	4306
Auh	3614
Mccc1	3231
Acat1	1915
Acad8	284
Ivd	-1246
Bcat2	-1263
Hibch	-1534
Mccc2	-3376

FGFR2 ALTERNATIVE SPLICING

FGFR2 ALTERNATIVE SPLICING
	325
set	FGFR2 ALTERNATIVE SPLICING
setSize	25
pANOVA	0.000165
s.dist	-0.435
p.adjustANOVA	0.00367

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hnrnph1	-7764
Polr2l	-7491
Hnrnpa1	-7092
Polr2k	-6751
Hnrnpm	-6544
Gtf2f1	-6432
Ncbp2	-6200
Polr2f	-5888
Tia1	-5491
Gtf2f2	-5390
Tial1	-5025
Polr2g	-4548
Ptbp1	-4342
Fgfr2	-4338
Polr2e	-4206
Polr2i	-4083
Polr2d	-3931
Polr2h	-1758
Polr2j	-1316
Polr2c	-1130

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hnrnph1	-7764
Polr2l	-7491
Hnrnpa1	-7092
Polr2k	-6751
Hnrnpm	-6544
Gtf2f1	-6432
Ncbp2	-6200
Polr2f	-5888
Tia1	-5491
Gtf2f2	-5390
Tial1	-5025
Polr2g	-4548
Ptbp1	-4342
Fgfr2	-4338
Polr2e	-4206
Polr2i	-4083
Polr2d	-3931
Polr2h	-1758
Polr2j	-1316
Polr2c	-1130
Rbfox2	1521
Hnrnpf	1903
Polr2a	2530
Ncbp1	2649
Polr2b	6541

SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
	1048
set	SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
setSize	16
pANOVA	0.0026
s.dist	0.435
p.adjustANOVA	0.0308

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fig4	8626
Mtmr2	8484
Pik3c2a	8120
Pik3c3	7990
Inpp4b	7886
Pi4k2a	7640
Vac14	7547
Mtmr4	4004
Mtmr12	2522
Inpp5f	2226
Pik3r4	1359
Pikfyve	957
Inpp4a	464
Mtmr10	463
Mtm1	-162
Pi4k2b	-1848

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fig4	8626
Mtmr2	8484
Pik3c2a	8120
Pik3c3	7990
Inpp4b	7886
Pi4k2a	7640
Vac14	7547
Mtmr4	4004
Mtmr12	2522
Inpp5f	2226
Pik3r4	1359
Pikfyve	957
Inpp4a	464
Mtmr10	463
Mtm1	-162
Pi4k2b	-1848

REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS
	786
set	REDUCTION OF CYTOSOLIC CA LEVELS
setSize	11
pANOVA	0.0132
s.dist	0.432
p.adjustANOVA	0.0885

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp2a2	6793
Slc8a2	6374
Atp2b3	6023
Sri	5522
Calm1	5178
Atp2b2	4527
Atp2b4	3902
Slc8a3	3321
Atp2a3	2206
Slc8a1	1827
Atp2b1	-390

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp2a2	6793
Slc8a2	6374
Atp2b3	6023
Sri	5522
Calm1	5178
Atp2b2	4527
Atp2b4	3902
Slc8a3	3321
Atp2a3	2206
Slc8a1	1827
Atp2b1	-390

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
	398
set	GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
setSize	12
pANOVA	0.00965
s.dist	0.431
p.adjustANOVA	0.076

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mapk1	8781
Uso1	8158
Cdk1	7663
Blzf1	7140
Gorasp2	5518
Rab2a	4325
Rab1b	4161
Golga2	2840
Gorasp1	1183
Mapk3	662
Rab1a	-136
Plk1	-918

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mapk1	8781
Uso1	8158
Cdk1	7663
Blzf1	7140
Gorasp2	5518
Rab2a	4325
Rab1b	4161
Golga2	2840
Gorasp1	1183
Mapk3	662
Rab1a	-136
Plk1	-918

RHOBTB2 GTPASE CYCLE

RHOBTB2 GTPASE CYCLE
	863
set	RHOBTB2 GTPASE CYCLE
setSize	23
pANOVA	0.000381
s.dist	-0.428
p.adjustANOVA	0.00738

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hsp90ab1	-7101
Hsp90aa1	-6761
Rbmx	-6579
Cct7	-6510
Rhobtb2	-6464
Phip	-6046
Ddx39b	-5634
Stk38	-5404
Cdc37	-5257
Actn1	-4407
Cct6a	-3374
Hnrnpc	-3371
Cct2	-3189
Actg1	-3112
Srrm1	-2908
Dbn1	-2870
Twf1	-1403
Cul3	-700
Tra2b	-526
Tmod3	-256

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hsp90ab1	-7101
Hsp90aa1	-6761
Rbmx	-6579
Cct7	-6510
Rhobtb2	-6464
Phip	-6046
Ddx39b	-5634
Stk38	-5404
Cdc37	-5257
Actn1	-4407
Cct6a	-3374
Hnrnpc	-3371
Cct2	-3189
Actg1	-3112
Srrm1	-2908
Dbn1	-2870
Twf1	-1403
Cul3	-700
Tra2b	-526
Tmod3	-256
Msi2	-106
Txnl1	1406
Myo6	4219

SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER

SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER
	976
set	SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER
setSize	15
pANOVA	0.00457
s.dist	-0.423
p.adjustANOVA	0.0462

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dll1	-8061
Rps27a	-7027
Adam17	-6639
Uba52	-6187
Jag1	-5926
Ubb	-5788
Jag2	-5784
Mib2	-2687
Neurl1b	-2633
Dll4	-2516
Ubc	-1603
Notch1	-183
Mib1	240
Adam10	1875
Neurl1a	3752

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dll1	-8061
Rps27a	-7027
Adam17	-6639
Uba52	-6187
Jag1	-5926
Ubb	-5788
Jag2	-5784
Mib2	-2687
Neurl1b	-2633
Dll4	-2516
Ubc	-1603
Notch1	-183
Mib1	240
Adam10	1875
Neurl1a	3752

CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
	155
set	CITRIC ACID CYCLE TCA CYCLE
setSize	22
pANOVA	0.000719
s.dist	0.417
p.adjustANOVA	0.0116

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aco2	8593
Suclg2	7625
Idh3a	7550
Idh3g	7000
Dld	6763
Sdhd	6426
Sucla2	6383
Ogdh	6275
Dlst	6258
Cs	6241
Me2	5731
Me3	5525
Idh3b	3887
Sdha	3177
Sdhc	2990
Sdhb	2836
Nnt	2202
Mdh2	1857
Fahd1	333
Suclg1	-2096

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aco2	8593
Suclg2	7625
Idh3a	7550
Idh3g	7000
Dld	6763
Sdhd	6426
Sucla2	6383
Ogdh	6275
Dlst	6258
Cs	6241
Me2	5731
Me3	5525
Idh3b	3887
Sdha	3177
Sdhc	2990
Sdhb	2836
Nnt	2202
Mdh2	1857
Fahd1	333
Suclg1	-2096
Fh1	-3436
Idh2	-4479

INFLUENZA INFECTION

INFLUENZA INFECTION
	446
set	INFLUENZA INFECTION
setSize	146
pANOVA	1.05e-17
s.dist	-0.411
p.adjustANOVA	1.24e-15

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Calr	-7980
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Isg15	-7748
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Polr2l	-7491

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Rpl23	-8173
Rpl39	-8168
Rps27	-8128
Rpl37	-8063
Rpl30	-8019
Calr	-7980
Rpl37a	-7975
Rps21	-7927
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Isg15	-7748
Rpl35	-7645
Rpl36a	-7632
Rpl23a	-7500
Polr2l	-7491
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Rpl31	-7250
Rplp1	-7160
Hspa1a	-7112
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Dnajc3	-6919
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Hsp90aa1	-6761
Polr2k	-6751
Rps26	-6585
Rpl29	-6490
Gtf2f1	-6432
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Rpl22	-5905
Fau	-5890
Polr2f	-5888
Nup37	-5823
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Rpl11	-5571
Rps24	-5471
Gtf2f2	-5390
Cpsf4	-5340
Rpl12	-5252
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Rps5	-4990
Rps9	-4981
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Rps3a1	-4631
Rpl6	-4589
Polr2g	-4548
Pabpn1	-4418
Rpl7	-4400
Rps13	-4263
Rpl27	-4253
Polr2e	-4206
Rps27l	-4091
Polr2i	-4083
Rps2	-4058
Rpl13a	-4006
Polr2d	-3931
Rpl17	-3909
Rps14	-3804
Rpsa	-3236
Kpna2	-3130
Tpr	-3104
Nupl2	-3085
Nup214	-2905
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Ran	-2597
Eif2ak2	-2453
Nup43	-2007
Nup93	-1936
Nup88	-1809
Nup35	-1805
Polr2h	-1758
Xpo1	-1739
Rps3	-1626
Polr2j	-1316
Rpl3l	-1143
Polr2c	-1130
Nup54	-916
Tgfb1	-846
Nup107	-429
Rae1	-317
Aaas	-92
Rpl5	46
Nup160	201
Rplp0	1020
Canx	1783
Rpl10	1911
Clta	1933
Nup98	1945
Sec13	2455
Polr2a	2530
Nup62	2773
Kpnb1	3448
Nup133	3501
Nup85	3707
Nup205	3866
Ipo5	4070
Kpna1	4396
Nup155	4730
Nup153	4823
Nup50	5555
Pom121	5939
Parp1	5986
Nup210	6217
Polr2b	6541
Nup188	7696
Seh1l	7799
Cltc	7910
Ndc1	8330
Ranbp2	8335
Kpna4	8786
Grsf1	8850
Kpna3	8953

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
	83
set	ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
setSize	10
pANOVA	0.0254
s.dist	-0.408
p.adjustANOVA	0.134

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspa5	-8172
Ddit3	-8171
Hsp90b1	-8155
Xbp1	-8038
Calr	-7980
Atf4	-3007
Nfyb	-2777
Nfya	954
Nfyc	5233
Atf6	8605

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspa5	-8172
Ddit3	-8171
Hsp90b1	-8155
Xbp1	-8038
Calr	-7980
Atf4	-3007
Nfyb	-2777
Nfya	954
Nfyc	5233
Atf6	8605

RHO GTPASES ACTIVATE NADPH OXIDASES

RHO GTPASES ACTIVATE NADPH OXIDASES
	854
set	RHO GTPASES ACTIVATE NADPH OXIDASES
setSize	21
pANOVA	0.00121
s.dist	0.408
p.adjustANOVA	0.0179

Top enriched genes

Top 20 genes
GeneID	Gene Rank
S100a8	9016
S100a9	9013
Ncf1	8854
Mapk1	8781
Prkcd	8220
Rac2	7994
Pik3c3	7990
Cybb	7023
Ncf4	6795
Noxo1	5728
Prkcb	4120
Pin1	2408
Mapk14	1527
Rac1	1495
Prkcz	1477
Pik3r4	1359
Prkca	847
Mapk3	662
Mapk11	-1982
Cyba	-3028

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
S100a8	9016
S100a9	9013
Ncf1	8854
Mapk1	8781
Prkcd	8220
Rac2	7994
Pik3c3	7990
Cybb	7023
Ncf4	6795
Noxo1	5728
Prkcb	4120
Pin1	2408
Mapk14	1527
Rac1	1495
Prkcz	1477
Pik3r4	1359
Prkca	847
Mapk3	662
Mapk11	-1982
Cyba	-3028
Ncf2	-6209

CAMK IV MEDIATED PHOSPHORYLATION OF CREB

CAMK IV MEDIATED PHOSPHORYLATION OF CREB
	112
set	CAMK IV MEDIATED PHOSPHORYLATION OF CREB
setSize	10
pANOVA	0.0259
s.dist	0.407
p.adjustANOVA	0.134

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Camk4	8156
Camkk1	8079
Camk2g	7554
Camkk2	6273
Calm1	5178
Camk2d	3466
Camk2a	2757
Creb1	1050
Camk2b	-357
Kpna2	-3130

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Camk4	8156
Camkk1	8079
Camk2g	7554
Camkk2	6273
Calm1	5178
Camk2d	3466
Camk2a	2757
Creb1	1050
Camk2b	-357
Kpna2	-3130

PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES

PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
	757
set	PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
setSize	13
pANOVA	0.0115
s.dist	0.405
p.adjustANOVA	0.0814

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Elmo2	8040
Crk	7897
Bcar1	7386
Elmo1	6602
Kras	6077
Dock1	5623
Rasa1	4617
Arhgap35	4380
Nras	4195
Rhoa	3577
Rac1	1495
Pxn	-3107
Hras	-6302

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Elmo2	8040
Crk	7897
Bcar1	7386
Elmo1	6602
Kras	6077
Dock1	5623
Rasa1	4617
Arhgap35	4380
Nras	4195
Rhoa	3577
Rac1	1495
Pxn	-3107
Hras	-6302

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
	29
set	ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
setSize	59
pANOVA	1.04e-07
s.dist	-0.4
p.adjustANOVA	5.36e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rps27	-8128
Eif3a	-8016
Rps21	-7927
Rps20	-7805
Rps23	-7780
Rps17	-7426
Rps8	-7421
Rps11	-7053
Rps27a	-7027
Eif4a1	-6776
Rps26	-6585
Rps7	-6355
Rps19	-6333
Eif2s2	-6239
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rps16	-5972

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rps27	-8128
Eif3a	-8016
Rps21	-7927
Rps20	-7805
Rps23	-7780
Rps17	-7426
Rps8	-7421
Rps11	-7053
Rps27a	-7027
Eif4a1	-6776
Rps26	-6585
Rps7	-6355
Rps19	-6333
Eif2s2	-6239
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rps16	-5972
Fau	-5890
Rps6	-5794
Rps15a	-5694
Rps24	-5471
Rps18	-5182
Rps5	-4990
Rps9	-4981
Rps4x	-4846
Rps3a1	-4631
Rps13	-4263
Rps27l	-4091
Rps2	-4058
Eif3j1	-3873
Rps14	-3804
Eif3g	-3606
Rpsa	-3236
Eif3k	-2953
Rps10	-2748
Eif3e	-2360
Rps3	-1626
Eif3j2	-684
Pabpc1	-661
Eif3c	-650
Eif4ebp1	-225
Eif3h	427
Eif3b	1202
Eif3l	1373
Eif2s3x	1484
Eif3f	1775
Eif3i	1893
Eif4e	2249
Eif3m	2474
Eif2s1	3113
Eif4g1	3132
Eif4b	3480
Eif3d	3617
Eif4h	5491
Eif4a2	6904
Eif1ax	7855

HSF1 ACTIVATION

HSF1 ACTIVATION
	433
set	HSF1 ACTIVATION
setSize	27
pANOVA	0.000354
s.dist	-0.397
p.adjustANOVA	0.00696

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Serpinh1	-8229
Hspb1	-7873
Hspa1b	-7483
Hsph1	-7270
Fkbp4	-7157
Hspa1a	-7112
Hsp90ab1	-7101
Hsf1	-6826
Hsp90aa1	-6761
Ptges3	-6622
Dnajb1	-6438
Ubb	-5788
Vcp	-5485
Hsbp1	-4782
Dnajb6	-4079
Mrpl18	-3308
Hdac6	-2027
Rln1	-2003
Hspb2	-1870
Eef1a1	-1720

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Serpinh1	-8229
Hspb1	-7873
Hspa1b	-7483
Hsph1	-7270
Fkbp4	-7157
Hspa1a	-7112
Hsp90ab1	-7101
Hsf1	-6826
Hsp90aa1	-6761
Ptges3	-6622
Dnajb1	-6438
Ubb	-5788
Vcp	-5485
Hsbp1	-4782
Dnajb6	-4079
Mrpl18	-3308
Hdac6	-2027
Rln1	-2003
Hspb2	-1870
Eef1a1	-1720
Ywhae	-928
Col4a6	2570
Dedd2	3130
Tnfrsf21	4245
Rpa2	4431
Rpa1	6660
Rpa3	7387

GLYCOSPHINGOLIPID METABOLISM

GLYCOSPHINGOLIPID METABOLISM
	395
set	GLYCOSPHINGOLIPID METABOLISM
setSize	37
pANOVA	3.18e-05
s.dist	0.395
p.adjustANOVA	0.000816

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Neu4	8948
Arsk	8683
Gba	8619
Neu3	8468
Cptp	8127
Esyt1	7918
Galc	7905
Esyt2	7822
Gla	7515
Cerk	7378
B4galnt1	7352
Arsb	7176
Psap	7077
Asah2	7051
Neu1	6836
Asah1	6624
B3galnt1	5729
Gba2	5576
Arsg	5409
Ctsa	4924

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Neu4	8948
Arsk	8683
Gba	8619
Neu3	8468
Cptp	8127
Esyt1	7918
Galc	7905
Esyt2	7822
Gla	7515
Cerk	7378
B4galnt1	7352
Arsb	7176
Psap	7077
Asah2	7051
Neu1	6836
Asah1	6624
B3galnt1	5729
Gba2	5576
Arsg	5409
Ctsa	4924
Smpd3	4718
Glb1	4008
Ugcg	3912
Gm2a	3507
Gltp	2546
Neu2	1517
Smpd1	1299
Glb1l	651
Smpd2	-54
Arsa	-315
Sumf1	-348
Esyt3	-2586
Smpd4	-2730
Hexb	-2797
Ugt8a	-4848
Hexa	-5919
Sumf2	-7239

SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS

SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS
	942
set	SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS
setSize	15
pANOVA	0.00815
s.dist	0.395
p.adjustANOVA	0.0687

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ppp2r1b	8351
Csnk1a1	7934
Ctnnb1	6376
Amer1	5741
Axin1	5591
Ppp2r5b	5022
Ppp2r5e	4146
Ppp2r1a	3759
Gsk3b	3069
Ppp2r5c	2264
Ppp2cb	2047
Apc	1731
Ppp2ca	1295
Ppp2r5a	1161
Ppp2r5d	-1563

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ppp2r1b	8351
Csnk1a1	7934
Ctnnb1	6376
Amer1	5741
Axin1	5591
Ppp2r5b	5022
Ppp2r5e	4146
Ppp2r1a	3759
Gsk3b	3069
Ppp2r5c	2264
Ppp2cb	2047
Apc	1731
Ppp2ca	1295
Ppp2r5a	1161
Ppp2r5d	-1563

COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
	172
set	COMPLEX I BIOGENESIS
setSize	56
pANOVA	4.45e-07
s.dist	-0.39
p.adjustANOVA	1.94e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ndufa1	-8060
Ndufa6	-7988
Ndufa5	-7932
mt-Nd3	-7789
Ndufv3	-7598
Ndufb1	-7589
mt-Nd6	-7554
Ndufa3	-7547
Ndufb3	-7138
Ndufs6	-7098
Ndufa2	-7083
Ndufb11	-6893
Ndufs5	-6865
Ndufa13	-6783
Ndufc1	-6652
Ndufa12	-6407
Ndufb10	-6167
Ndufaf3	-6115
Ndufb7	-6023
Tmem126b	-5436

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ndufa1	-8060
Ndufa6	-7988
Ndufa5	-7932
mt-Nd3	-7789
Ndufv3	-7598
Ndufb1	-7589
mt-Nd6	-7554
Ndufa3	-7547
Ndufb3	-7138
Ndufs6	-7098
Ndufa2	-7083
Ndufb11	-6893
Ndufs5	-6865
Ndufa13	-6783
Ndufc1	-6652
Ndufa12	-6407
Ndufb10	-6167
Ndufaf3	-6115
Ndufb7	-6023
Tmem126b	-5436
Ndufb2	-5077
Ndufab1	-4718
mt-Nd1	-4601
Ndufc2	-4423
Ndufb9	-4375
Ndufb5	-3445
Tmem186	-2778
Ndufv2	-2738
Ndufs4	-2542
Ndufaf6	-2510
Ndufa8	-2269
Ndufaf4	-2253
Ndufaf2	-2132
mt-Nd4	-2025
mt-Nd2	-1785
Ndufaf7	-1774
Ndufs8	-1647
Ndufs3	-1519
Ndufb6	-1479
Ndufb4	-1400
Ndufa7	-772
Ndufa11	-649
Ndufaf1	-430
Ndufb8	-354
Ndufs2	-268
Ndufaf5	35
Timmdc1	104
Ndufv1	134
Ndufs7	383
Ndufa10	487
Nubpl	2273
Ndufa9	4322
Ecsit	4658
mt-Nd5	5254
Ndufs1	6700
Acad9	7136

RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
	864
set	RHOBTB3 ATPASE CYCLE
setSize	10
pANOVA	0.0337
s.dist	0.388
p.adjustANOVA	0.149

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Plin3	7471
Rhobtb3	7067
Rab9b	6638
Ccne1	6166
Vhl	5925
Htr7	5082
Lrrc41	2620
Hgs	1686
Cul3	-700
Rab9	-4571

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Plin3	7471
Rhobtb3	7067
Rab9b	6638
Ccne1	6166
Vhl	5925
Htr7	5082
Lrrc41	2620
Hgs	1686
Cul3	-700
Rab9	-4571

DEGRADATION OF CYSTEINE AND HOMOCYSTEINE

DEGRADATION OF CYSTEINE AND HOMOCYSTEINE
	224
set	DEGRADATION OF CYSTEINE AND HOMOCYSTEINE
setSize	13
pANOVA	0.0157
s.dist	0.387
p.adjustANOVA	0.0989

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Suox	7686
Cth	6451
Slc25a10	6416
Csad	6215
Got2	6181
Ado	5838
Gadl1	5160
Mpst	3414
Ethe1	2960
Sqor	2279
Cdo1	673
Txn2	-417
Tst	-4388

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Suox	7686
Cth	6451
Slc25a10	6416
Csad	6215
Got2	6181
Ado	5838
Gadl1	5160
Mpst	3414
Ethe1	2960
Sqor	2279
Cdo1	673
Txn2	-417
Tst	-4388

BETA CATENIN PHOSPHORYLATION CASCADE

BETA CATENIN PHOSPHORYLATION CASCADE
	95
set	BETA CATENIN PHOSPHORYLATION CASCADE
setSize	16
pANOVA	0.00751
s.dist	0.386
p.adjustANOVA	0.0652

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ppp2r1b	8351
Csnk1a1	7934
Ctnnb1	6376
Amer1	5741
Axin1	5591
Ppp2r5b	5022
Ppp2r5e	4146
Ppp2r1a	3759
Gsk3b	3069
Frat2	2606
Ppp2r5c	2264
Ppp2cb	2047
Apc	1731
Ppp2ca	1295
Ppp2r5a	1161
Ppp2r5d	-1563

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ppp2r1b	8351
Csnk1a1	7934
Ctnnb1	6376
Amer1	5741
Axin1	5591
Ppp2r5b	5022
Ppp2r5e	4146
Ppp2r1a	3759
Gsk3b	3069
Frat2	2606
Ppp2r5c	2264
Ppp2cb	2047
Apc	1731
Ppp2ca	1295
Ppp2r5a	1161
Ppp2r5d	-1563

G PROTEIN ACTIVATION

G PROTEIN ACTIVATION
	357
set	G PROTEIN ACTIVATION
setSize	23
pANOVA	0.00139
s.dist	-0.385
p.adjustANOVA	0.0202

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pomc	-8121
Gng11	-7971
Gng5	-7495
Gnaq	-6362
Gng13	-6025
Pdyn	-5936
Gna11	-5869
Gna15	-5309
Gnb2	-5029
Gnb3	-4857
Gng3	-4751
Gngt2	-3900
Gng2	-3829
Gng4	-3774
Gna14	-3437
Gng10	-2501
Gnb4	-1920
Oprm1	-780
Gnb1	-65
Gng8	1475

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pomc	-8121
Gng11	-7971
Gng5	-7495
Gnaq	-6362
Gng13	-6025
Pdyn	-5936
Gna11	-5869
Gna15	-5309
Gnb2	-5029
Gnb3	-4857
Gng3	-4751
Gngt2	-3900
Gng2	-3829
Gng4	-3774
Gna14	-3437
Gng10	-2501
Gnb4	-1920
Oprm1	-780
Gnb1	-65
Gng8	1475
Gng7	4108
Gng12	6533
Gnb5	7981

STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS

STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS
	1016
set	STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS
setSize	10
pANOVA	0.0351
s.dist	0.385
p.adjustANOVA	0.153

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Bcl2l1	8916
Ptpn11	8833
Cdkn1a	8310
Flt3	6517
Stat5b	5705
Pim1	4435
Nox4	3163
Gab2	658
Stat5a	-3867
Grb2	-5559

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Bcl2l1	8916
Ptpn11	8833
Cdkn1a	8310
Flt3	6517
Stat5b	5705
Pim1	4435
Nox4	3163
Gab2	658
Stat5a	-3867
Grb2	-5559

FCGR ACTIVATION

FCGR ACTIVATION
	321
set	FCGR ACTIVATION
setSize	11
pANOVA	0.0284
s.dist	0.382
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ighg2c	9022
Igkv19-93	8911
Hck	7620
Fyn	7293
Fgr	6518
Syk	5230
Fcgr3	4277
Lyn	1771
Src	1013
Yes1	-2931
Fcgr1	-8194

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ighg2c	9022
Igkv19-93	8911
Hck	7620
Fyn	7293
Fgr	6518
Syk	5230
Fcgr3	4277
Lyn	1771
Src	1013
Yes1	-2931
Fcgr1	-8194

RNA POLYMERASE II TRANSCRIPTION TERMINATION

RNA POLYMERASE II TRANSCRIPTION TERMINATION
	883
set	RNA POLYMERASE II TRANSCRIPTION TERMINATION
setSize	65
pANOVA	1.37e-07
s.dist	-0.378
p.adjustANOVA	6.72e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Upf3b	-8113
Snrpf	-8050
U2af1	-8027
Rbm8a	-7850
Alyref	-7740
Snrpe	-7726
Sarnp	-7240
Srsf9	-7181
Snrpd3	-7029
Snrpg	-7014
Magohb	-6884
Nudt21	-6797
Pcf11	-6563
Srsf4	-6349
Ddx39a	-6217
Thoc1	-6213
Ncbp2	-6200
Zc3h11a	-6125
Thoc3	-6071
Slu7	-6024

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Upf3b	-8113
Snrpf	-8050
U2af1	-8027
Rbm8a	-7850
Alyref	-7740
Snrpe	-7726
Sarnp	-7240
Srsf9	-7181
Snrpd3	-7029
Snrpg	-7014
Magohb	-6884
Nudt21	-6797
Pcf11	-6563
Srsf4	-6349
Ddx39a	-6217
Thoc1	-6213
Ncbp2	-6200
Zc3h11a	-6125
Thoc3	-6071
Slu7	-6024
Srsf11	-5997
Srsf2	-5842
U2af2	-5806
Ddx39b	-5634
U2af1l4	-5563
Lsm10	-5519
Cpsf4	-5340
Eif4a3	-5319
Magoh	-5137
Chtop	-4958
Thoc2	-4940
Srsf7	-4758
Srsf6	-4522
Thoc7	-4438
Pabpn1	-4418
Srsf5	-4141
Zfp473	-4088
Cpsf7	-3129
Srrm1	-2908
Srsf1	-2853
Rnps1	-2675
Cstf1	-2537
Srsf3	-2456
Cstf2	-1888
Papola	-1568
Dhx38	-828
Poldip3	-795
Cpsf3	-729
Cpsf1	-326
Cstf3	-322
Casc3	400
Thoc5	839
Clp1	914
Sympk	1357
Ncbp1	2649
Slbp	2898
Wdr33	3038
Snrpb	3917
Cpsf2	4667
Thoc6	5270
Fip1l1	6218
Lsm11	6559
Fyttd1	6619
Cstf2t	7946
Cdc40	8378

GLUTAMATE AND GLUTAMINE METABOLISM

GLUTAMATE AND GLUTAMINE METABOLISM
	384
set	GLUTAMATE AND GLUTAMINE METABOLISM
setSize	13
pANOVA	0.0188
s.dist	0.376
p.adjustANOVA	0.108

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Glul	8979
Glud1	8860
Rimkla	6464
Got2	6181
Aldh18a1	5490
Oat	5236
Kyat1	4467
Gls2	4264
Pycr1	2739
Pycr2	1005
Gls	374
Rimklb	-1192
Pycrl	-5573

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Glul	8979
Glud1	8860
Rimkla	6464
Got2	6181
Aldh18a1	5490
Oat	5236
Kyat1	4467
Gls2	4264
Pycr1	2739
Pycr2	1005
Gls	374
Rimklb	-1192
Pycrl	-5573

RRNA PROCESSING

RRNA PROCESSING
	898
set	RRNA PROCESSING
setSize	195
pANOVA	1.4e-19
s.dist	-0.376
p.adjustANOVA	2.06e-17

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Utp3	-8205
Rpl23	-8173
Rpl39	-8168
Nop58	-8147
Rps27	-8128
Fbl	-8080
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Gar1	-7972
Rps21	-7927
Krr1	-7912
Isg20l2	-7870
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps28	-8246
Rps29	-8238
Rpl38	-8230
Utp3	-8205
Rpl23	-8173
Rpl39	-8168
Nop58	-8147
Rps27	-8128
Fbl	-8080
Rpl37	-8063
Rpl30	-8019
Rpl37a	-7975
Gar1	-7972
Rps21	-7927
Krr1	-7912
Isg20l2	-7870
Rpl21	-7822
Rps20	-7805
Rps23	-7780
Rpl36al	-7752
Mphosph10	-7658
Rpl35	-7645
Rpl36a	-7632
Ncl	-7611
Dkc1	-7545
Bms1	-7542
Trmt112	-7513
Rpl23a	-7500
Rpl35a	-7461
Rps17	-7426
Rps8	-7421
Tex10	-7349
Dcaf13	-7344
Mphosph6	-7318
Rpl31	-7250
Rplp1	-7160
Rpl26	-7071
Rps11	-7053
Rps27a	-7027
Rpl24	-7004
Rpp21	-7003
Rpl10a	-6880
Rpl36	-6858
Rpl14	-6787
Exosc10	-6771
Rrp1	-6657
Tfb1m	-6643
Rps26	-6585
Las1l	-6571
Nop14	-6550
Rpl29	-6490
Ddx21	-6363
Rps7	-6355
Rplp2	-6350
Rps19	-6333
Rpl22l1	-6218
Rpl34	-6199
Uba52	-6187
Rpl32	-6163
Rpl18	-6160
Nol12	-6128
Rps12	-6097
Rps25	-6061
Rps15	-6034
Rpl28	-5977
Rps16	-5972
Ftsj3	-5931
Exosc4	-5921
Rpl22	-5905
Fau	-5890
Rps6	-5794
Rpl19	-5752
Rpl15	-5718
Rps15a	-5694
Exosc7	-5608
Rpl11	-5571
Rps24	-5471
Mterf4	-5460
Ebna1bp2	-5265
Rpl12	-5252
Gnl3	-5239
Rps18	-5182
Rpl13	-5180
Rpl27a	-5162
Rpl4	-5136
Exosc3	-5119
Rps5	-4990
Rps9	-4981
Csnk1e	-4914
Rpp38	-4903
Rpl8	-4888
Rps4x	-4846
Rpl3	-4835
Rpl18a	-4813
Utp11	-4798
Rps3a1	-4631
Rpl6	-4589
Rpl7	-4400
Bysl	-4399
Nop10	-4303
Rps13	-4263
Rpl27	-4253
Bud23	-4137
Rps27l	-4091
Rps2	-4058
Rpl13a	-4006
Rpl17	-3909
Nop2	-3885
Fcf1	-3879
Rps14	-3804
Rpp25	-3503
Utp14a	-3360
Rpp40	-3349
Pelp1	-3344
C1d	-3335
Imp3	-3334
Pdcd11	-3295
Rrp9	-3259
Rpsa	-3236
Rpl7a	-2903
Rpl9	-2750
Rps10	-2748
Utp18	-2744
Rrp7a	-2728
Dis3	-2517
Rbm28	-2493
Nat10	-2270
Imp4	-2212
Nhp2	-2116
Dimt1	-1988
Rps3	-1626
Utp15	-1549
Rpp30	-1355
Rpl3l	-1143
Wdr75	-1100
Wdr12	-1065
Nop56	-998
Pwp2	-769
Rrp36	-680
Exosc5	-520
Nob1	-330
Wdr36	-296
Emg1	-67
Riok1	-18
Rpl5	46
Ltv1	108
Snu13	196
Dhx37	225
Heatr1	402
Mrm3	518
Ddx52	631
Utp20	900
Tsr3	969
Rplp0	1020
Rpl10	1911
Trmt10c	2250
Pno1	2277
Exosc9	2407
Rcl1	2409
Exosc1	2539
Wdr46	2713
Utp25	2756
Pes1	3117
Mrm2	3276
Exosc8	3539
Utp4	3826
Rpp14	3903
Ddx47	3985
Thumpd1	4112
Senp3	4271
Exosc2	4603
Wdr3	4681
Utp6	4746
Wdr43	4757
Eri1	4785
Nol6	4858
Wdr18	5003
Csnk1d	5019
Ddx49	5071
Mtrex	5124
Riok3	5139
Nip7	5444
Elac2	5470
Hsd17b10	5880
Riok2	6324
Prorp	6665
Nol11	6732
Tsr1	7152
Noc4l	7257
Bop1	7426
Nol9	7493
Nsun4	7675
Xrn2	7703
Tbl3	8699
Mrm1	8798

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
	1049
set	SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
setSize	15
pANOVA	0.0136
s.dist	0.368
p.adjustANOVA	0.0892

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fig4	8626
Sacm1l	8219
Pik3c2a	8120
Pik3c3	7990
Pi4k2a	7640
Vac14	7547
Pi4ka	3300
Inpp5e	2856
Arf1	1916
Pik3r4	1359
Pikfyve	957
Ocrl	-20
Arf3	-131
Pi4k2b	-1848
Pi4kb	-3043

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fig4	8626
Sacm1l	8219
Pik3c2a	8120
Pik3c3	7990
Pi4k2a	7640
Vac14	7547
Pi4ka	3300
Inpp5e	2856
Arf1	1916
Pik3r4	1359
Pikfyve	957
Ocrl	-20
Arf3	-131
Pi4k2b	-1848
Pi4kb	-3043

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION
	442
set	INCRETIN SYNTHESIS SECRETION AND INACTIVATION
setSize	14
pANOVA	0.0186
s.dist	-0.363
p.adjustANOVA	0.108

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Grp	-6868
Gng13	-6025
Sec11c	-5958
Isl1	-5637
Tcf7l2	-5581
Spcs1	-5121
Gnb3	-4857
Spcs2	-4537
Sec11a	-3700
Dpp4	-3478
Pax6	-794
Pcsk1	-359
Ctnnb1	6376
Spcs3	7852

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Grp	-6868
Gng13	-6025
Sec11c	-5958
Isl1	-5637
Tcf7l2	-5581
Spcs1	-5121
Gnb3	-4857
Spcs2	-4537
Sec11a	-3700
Dpp4	-3478
Pax6	-794
Pcsk1	-359
Ctnnb1	6376
Spcs3	7852

CHEMOKINE RECEPTORS BIND CHEMOKINES

CHEMOKINE RECEPTORS BIND CHEMOKINES
	146
set	CHEMOKINE RECEPTORS BIND CHEMOKINES
setSize	18
pANOVA	0.00781
s.dist	-0.362
p.adjustANOVA	0.0663

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ccr5	-7984
Cxcl12	-7200
Cxcl1	-7162
Cx3cr1	-6711
Ccl25	-5824
Ccrl2	-4778
Ccl27a	-4404
Ccr9	-3980
Ccr10	-3607
Ccl19	-3284
Ackr3	-3235
Cxcr4	-1892
Pf4	-1725
Ackr4	54
Cx3cl1	217
Cxcl16	3198
Ccl28	4200
Ccr2	4577

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ccr5	-7984
Cxcl12	-7200
Cxcl1	-7162
Cx3cr1	-6711
Ccl25	-5824
Ccrl2	-4778
Ccl27a	-4404
Ccr9	-3980
Ccr10	-3607
Ccl19	-3284
Ackr3	-3235
Cxcr4	-1892
Pf4	-1725
Ackr4	54
Cx3cl1	217
Cxcl16	3198
Ccl28	4200
Ccr2	4577

ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES

ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
	76
set	ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
setSize	10
pANOVA	0.0496
s.dist	0.359
p.adjustANOVA	0.184

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Furin	7831
Mbtps2	7435
Angptl4	6659
Pcsk6	6642
Mbtps1	5661
Lmf2	2394
Lmf1	1068
Lpl	-128
Pcsk5	-521
Angptl3	-2195

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Furin	7831
Mbtps2	7435
Angptl4	6659
Pcsk6	6642
Mbtps1	5661
Lmf2	2394
Lmf1	1068
Lpl	-128
Pcsk5	-521
Angptl3	-2195

SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS

SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS
	1004
set	SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS
setSize	11
pANOVA	0.0415
s.dist	-0.355
p.adjustANOVA	0.166

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Snrpf	-8050
Snrpe	-7726
Snrpd3	-7029
Snrpg	-7014
Ncbp2	-6200
Lsm10	-5519
Zfp473	-4088
Ncbp1	2649
Slbp	2898
Snrpb	3917
Lsm11	6559

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Snrpf	-8050
Snrpe	-7726
Snrpd3	-7029
Snrpg	-7014
Ncbp2	-6200
Lsm10	-5519
Zfp473	-4088
Ncbp1	2649
Slbp	2898
Snrpb	3917
Lsm11	6559

DISEASES OF DNA REPAIR

DISEASES OF DNA REPAIR
	241
set	DISEASES OF DNA REPAIR
setSize	11
pANOVA	0.0431
s.dist	-0.352
p.adjustANOVA	0.17

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nthl1	-7941
Ogg1	-6237
Mlh1	-5732
Mutyh	-5446
Bard1	-5403
Neil1	-4824
Pms2	-1350
Msh3	342
Msh2	924
Brca1	1622
Msh6	4710

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nthl1	-7941
Ogg1	-6237
Mlh1	-5732
Mutyh	-5446
Bard1	-5403
Neil1	-4824
Pms2	-1350
Msh3	342
Msh2	924
Brca1	1622
Msh6	4710

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.3                echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.4               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58.1               fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.1        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.4        
## [23] IRanges_2.30.1              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.2               stringr_1.4.1              
## [29] dplyr_1.0.10                purrr_0.3.5                
## [31] readr_2.1.3                 tidyr_1.2.1                
## [33] tibble_3.1.8                ggplot2_3.3.6              
## [35] tidyverse_1.3.2             zoo_1.8-11                 
## 
## loaded via a namespace (and not attached):
##   [1] googledrive_2.0.0      colorspace_2.0-3       ellipsis_0.3.2        
##   [4] XVector_0.36.0         fs_1.5.2               rstudioapi_0.14       
##   [7] bit64_4.0.5            AnnotationDbi_1.58.0   fansi_1.0.3           
##  [10] lubridate_1.8.0        xml2_1.3.3             codetools_0.2-18      
##  [13] splines_4.2.1          cachem_1.0.6           knitr_1.40            
##  [16] geneplotter_1.74.0     jsonlite_1.8.2         broom_1.0.1           
##  [19] annotate_1.74.0        dbplyr_2.2.1           png_0.1-7             
##  [22] shiny_1.7.2            compiler_4.2.1         httr_1.4.4            
##  [25] backports_1.4.1        assertthat_0.2.1       Matrix_1.5-1          
##  [28] fastmap_1.1.0          gargle_1.2.1           cli_3.4.1             
##  [31] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
##  [34] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
##  [37] fastmatch_1.1-3        Rcpp_1.0.9             jquerylib_0.1.4       
##  [40] cellranger_1.1.0       vctrs_0.4.2            Biostrings_2.64.1     
##  [43] svglite_2.1.0          xfun_0.33              rvest_1.0.3           
##  [46] mime_0.12              lifecycle_1.0.3        XML_3.99-0.11         
##  [49] googlesheets4_1.0.1    zlibbioc_1.42.0        scales_1.2.1          
##  [52] hms_1.1.2              promises_1.2.0.1       parallel_4.2.1        
##  [55] RColorBrewer_1.1-3     yaml_2.3.5             memoise_2.0.1         
##  [58] gridExtra_2.3          sass_0.4.2             reshape_0.8.9         
##  [61] stringi_1.7.8          RSQLite_2.2.18         highr_0.9             
##  [64] genefilter_1.78.0      caTools_1.18.2         BiocParallel_1.30.3   
##  [67] systemfonts_1.0.4      rlang_1.0.6            pkgconfig_2.0.3       
##  [70] bitops_1.0-7           evaluate_0.17          lattice_0.20-45       
##  [73] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.2.0      
##  [76] plyr_1.8.7             magrittr_2.0.3         R6_2.5.1              
##  [79] generics_0.1.3         DelayedArray_0.22.0    DBI_1.1.3             
##  [82] pillar_1.8.1           haven_2.5.1            withr_2.5.0           
##  [85] survival_3.4-0         KEGGREST_1.36.3        RCurl_1.98-1.9        
##  [88] modelr_0.1.9           crayon_1.5.2           KernSmooth_2.23-20    
##  [91] utf8_1.2.2             rmarkdown_2.17         tzdb_0.3.0            
##  [94] locfit_1.5-9.6         grid_4.2.1             readxl_1.4.1          
##  [97] data.table_1.14.2      blob_1.2.3             webshot_0.5.4         
## [100] reprex_2.0.2           digest_0.6.29          xtable_1.8-4          
## [103] httpuv_1.6.6           munsell_0.5.0          viridisLite_0.4.1     
## [106] bslib_0.4.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports