Mitch Report

date generated: 2023-07-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   x
##        -35.37246663
## A2M    -13.13626596
## A4GALT  -0.07278225
## AAAS    -4.33508400
## AACS     2.13961007
## AADAC   -2.90578338

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2612
num_genes_in_profile	13505
duplicated_genes_present	0
num_profile_genes_in_sets	7804
num_profile_genes_not_in_sets	5701

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ../ref/ReactomePathways_2023-07-14.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2612
num_genesets_excluded	1169
num_genesets_included	1443

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Metallothioneins bind metals	10	1.22e-05	0.799	1.35e-03
Response to metal ions	13	8.26e-06	0.714	9.94e-04
Degradation of cysteine and homocysteine	11	3.13e-04	-0.628	1.61e-02
Crosslinking of collagen fibrils	16	1.19e-04	0.556	7.15e-03
Activation of Matrix Metalloproteinases	22	1.30e-05	0.537	1.35e-03
Collagen degradation	47	8.14e-10	0.518	4.35e-07
Caspase activation via Death Receptors in the presence of ligand	12	1.96e-03	0.516	4.69e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	2.00e-03	0.515	4.69e-02
Collagen chain trimerization	30	1.35e-06	0.510	1.77e-04
Advanced glycosylation endproduct receptor signaling	12	2.78e-03	0.499	5.49e-02
Cholesterol biosynthesis	24	3.63e-05	0.487	2.76e-03
Collagen biosynthesis and modifying enzymes	50	4.06e-09	0.481	9.77e-07
Cell-extracellular matrix interactions	18	4.42e-04	0.478	2.11e-02
Nitric oxide stimulates guanylate cyclase	13	2.90e-03	-0.477	5.57e-02
p130Cas linkage to MAPK signaling for integrins	12	6.53e-03	0.453	8.73e-02
MyD88 deficiency (TLR2/4)	11	1.26e-02	0.434	1.30e-01
Integrin cell surface interactions	63	2.72e-09	0.433	7.85e-07
GABA synthesis, release, reuptake and degradation	13	7.38e-03	-0.429	9.47e-02
Formation of axial mesoderm	10	2.11e-02	-0.421	1.61e-01
ECM proteoglycans	61	1.71e-08	0.418	3.08e-06
Other semaphorin interactions	16	5.07e-03	0.405	7.38e-02
Signal transduction by L1	21	1.62e-03	0.397	4.36e-02
IRAK4 deficiency (TLR2/4)	12	2.28e-02	0.380	1.65e-01
Collagen formation	68	6.69e-08	0.379	9.65e-06
Integrin signaling	23	1.68e-03	0.379	4.36e-02
Sulfur amino acid metabolism	23	1.69e-03	-0.378	4.36e-02
Triglyceride biosynthesis	10	3.90e-02	-0.377	2.18e-01
Syndecan interactions	24	1.41e-03	0.377	4.36e-02
cGMP effects	10	4.09e-02	-0.373	2.20e-01
The NLRP3 inflammasome	13	2.07e-02	0.371	1.60e-01
Assembly of collagen fibrils and other multimeric structures	47	2.46e-05	0.356	2.22e-03
Signal regulatory protein family interactions	13	2.73e-02	0.354	1.82e-01
Chemokine receptors bind chemokines	27	1.57e-03	0.352	4.36e-02
Regulation of FOXO transcriptional activity by acetylation	10	5.49e-02	-0.351	2.60e-01
Inflammasomes	16	1.59e-02	0.348	1.46e-01
Degradation of the extracellular matrix	107	9.05e-10	0.343	4.35e-07
Defective Intrinsic Pathway for Apoptosis	21	6.79e-03	0.341	8.99e-02
Smooth Muscle Contraction	29	1.47e-03	0.341	4.36e-02
Synaptic adhesion-like molecules	20	1.13e-02	-0.327	1.22e-01
Classical antibody-mediated complement activation	13	4.13e-02	0.327	2.20e-01
PIWI-interacting RNA (piRNA) biogenesis	26	3.94e-03	-0.327	6.61e-02
Processing of SMDT1	12	5.16e-02	0.325	2.51e-01
Norepinephrine Neurotransmitter Release Cycle	13	4.31e-02	-0.324	2.26e-01
Phase 0 - rapid depolarisation	24	6.34e-03	-0.322	8.54e-02
Signaling by PDGF	49	1.01e-04	0.321	6.34e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	1.87e-02	-0.320	1.56e-01
Phase 2 - plateau phase	10	8.09e-02	-0.319	3.22e-01
Scavenging by Class A Receptors	16	3.08e-02	0.312	1.93e-01
Cellular hexose transport	15	3.78e-02	-0.310	2.18e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	19	2.04e-02	0.307	1.59e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Metallothioneins bind metals	10	1.22e-05	0.799000	1.35e-03
Response to metal ions	13	8.26e-06	0.714000	9.94e-04
Degradation of cysteine and homocysteine	11	3.13e-04	-0.628000	1.61e-02
Crosslinking of collagen fibrils	16	1.19e-04	0.556000	7.15e-03
Activation of Matrix Metalloproteinases	22	1.30e-05	0.537000	1.35e-03
Collagen degradation	47	8.14e-10	0.518000	4.35e-07
Caspase activation via Death Receptors in the presence of ligand	12	1.96e-03	0.516000	4.69e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	2.00e-03	0.515000	4.69e-02
Collagen chain trimerization	30	1.35e-06	0.510000	1.77e-04
Advanced glycosylation endproduct receptor signaling	12	2.78e-03	0.499000	5.49e-02
Cholesterol biosynthesis	24	3.63e-05	0.487000	2.76e-03
Collagen biosynthesis and modifying enzymes	50	4.06e-09	0.481000	9.77e-07
Cell-extracellular matrix interactions	18	4.42e-04	0.478000	2.11e-02
Nitric oxide stimulates guanylate cyclase	13	2.90e-03	-0.477000	5.57e-02
p130Cas linkage to MAPK signaling for integrins	12	6.53e-03	0.453000	8.73e-02
MyD88 deficiency (TLR2/4)	11	1.26e-02	0.434000	1.30e-01
Integrin cell surface interactions	63	2.72e-09	0.433000	7.85e-07
GABA synthesis, release, reuptake and degradation	13	7.38e-03	-0.429000	9.47e-02
Formation of axial mesoderm	10	2.11e-02	-0.421000	1.61e-01
ECM proteoglycans	61	1.71e-08	0.418000	3.08e-06
Other semaphorin interactions	16	5.07e-03	0.405000	7.38e-02
Signal transduction by L1	21	1.62e-03	0.397000	4.36e-02
IRAK4 deficiency (TLR2/4)	12	2.28e-02	0.380000	1.65e-01
Collagen formation	68	6.69e-08	0.379000	9.65e-06
Integrin signaling	23	1.68e-03	0.379000	4.36e-02
Sulfur amino acid metabolism	23	1.69e-03	-0.378000	4.36e-02
Triglyceride biosynthesis	10	3.90e-02	-0.377000	2.18e-01
Syndecan interactions	24	1.41e-03	0.377000	4.36e-02
cGMP effects	10	4.09e-02	-0.373000	2.20e-01
The NLRP3 inflammasome	13	2.07e-02	0.371000	1.60e-01
Assembly of collagen fibrils and other multimeric structures	47	2.46e-05	0.356000	2.22e-03
Signal regulatory protein family interactions	13	2.73e-02	0.354000	1.82e-01
Chemokine receptors bind chemokines	27	1.57e-03	0.352000	4.36e-02
Regulation of FOXO transcriptional activity by acetylation	10	5.49e-02	-0.351000	2.60e-01
Inflammasomes	16	1.59e-02	0.348000	1.46e-01
Degradation of the extracellular matrix	107	9.05e-10	0.343000	4.35e-07
Defective Intrinsic Pathway for Apoptosis	21	6.79e-03	0.341000	8.99e-02
Smooth Muscle Contraction	29	1.47e-03	0.341000	4.36e-02
Synaptic adhesion-like molecules	20	1.13e-02	-0.327000	1.22e-01
Classical antibody-mediated complement activation	13	4.13e-02	0.327000	2.20e-01
PIWI-interacting RNA (piRNA) biogenesis	26	3.94e-03	-0.327000	6.61e-02
Processing of SMDT1	12	5.16e-02	0.325000	2.51e-01
Norepinephrine Neurotransmitter Release Cycle	13	4.31e-02	-0.324000	2.26e-01
Phase 0 - rapid depolarisation	24	6.34e-03	-0.322000	8.54e-02
Signaling by PDGF	49	1.01e-04	0.321000	6.34e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	1.87e-02	-0.320000	1.56e-01
Phase 2 - plateau phase	10	8.09e-02	-0.319000	3.22e-01
Scavenging by Class A Receptors	16	3.08e-02	0.312000	1.93e-01
Cellular hexose transport	15	3.78e-02	-0.310000	2.18e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	19	2.04e-02	0.307000	1.59e-01
Neurodegenerative Diseases	19	2.04e-02	0.307000	1.59e-01
Somitogenesis	47	2.69e-04	0.307000	1.49e-02
TRAF6 mediated NF-kB activation	18	2.43e-02	0.307000	1.70e-01
Acyl chain remodelling of PI	10	9.47e-02	0.305000	3.45e-01
Signaling by high-kinase activity BRAF mutants	29	4.49e-03	0.305000	6.95e-02
Na+/Cl- dependent neurotransmitter transporters	12	6.78e-02	-0.304000	2.94e-01
Extracellular matrix organization	231	2.90e-15	0.302000	4.19e-12
Chaperone Mediated Autophagy	19	2.27e-02	-0.302000	1.65e-01
Presynaptic depolarization and calcium channel opening	11	8.32e-02	-0.302000	3.26e-01
Scavenging of heme from plasma	17	3.18e-02	0.301000	1.97e-01
Platelet Aggregation (Plug Formation)	30	4.37e-03	0.301000	6.95e-02
Infection with Mycobacterium tuberculosis	20	2.01e-02	0.300000	1.59e-01
Prefoldin mediated transfer of substrate to CCT/TriC	22	1.53e-02	0.299000	1.45e-01
Serotonin Neurotransmitter Release Cycle	14	5.63e-02	-0.295000	2.64e-01
Interleukin-10 signaling	25	1.10e-02	0.294000	1.21e-01
CLEC7A (Dectin-1) induces NFAT activation	11	9.15e-02	0.294000	3.39e-01
MAP2K and MAPK activation	33	3.63e-03	0.293000	6.33e-02
Germ layer formation at gastrulation	13	6.92e-02	-0.291000	2.94e-01
Regulation of NPAS4 gene expression	12	8.32e-02	0.289000	3.26e-01
Non-integrin membrane-ECM interactions	49	4.87e-04	0.288000	2.19e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	1.17e-01	0.286000	3.83e-01
Condensation of Prometaphase Chromosomes	11	1.01e-01	0.285000	3.59e-01
PKA activation	13	7.74e-02	-0.283000	3.12e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	9.34e-02	0.280000	3.42e-01
MET activates PTK2 signaling	26	1.36e-02	0.280000	1.36e-01
Fertilization	11	1.09e-01	0.279000	3.72e-01
Heme degradation	13	8.28e-02	0.278000	3.26e-01
Metabolism of Angiotensinogen to Angiotensins	10	1.31e-01	0.276000	4.06e-01
MET promotes cell motility	36	4.41e-03	0.274000	6.95e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	11	1.21e-01	0.270000	3.89e-01
PKA-mediated phosphorylation of CREB	15	7.08e-02	-0.269000	2.95e-01
Expression and translocation of olfactory receptors	16	6.24e-02	0.269000	2.80e-01
O-glycosylation of TSR domain-containing proteins	27	1.57e-02	0.269000	1.45e-01
Regulation of TLR by endogenous ligand	13	9.38e-02	0.268000	3.43e-01
Diseases associated with N-glycosylation of proteins	19	4.62e-02	0.264000	2.38e-01
Initial triggering of complement	22	3.22e-02	0.264000	1.98e-01
Negative regulation of FLT3	11	1.31e-01	0.263000	4.06e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	6.90e-02	0.263000	2.94e-01
Creation of C4 and C2 activators	16	7.01e-02	0.262000	2.94e-01
Class I peroxisomal membrane protein import	17	6.21e-02	-0.261000	2.80e-01
Physiological factors	11	1.34e-01	0.261000	4.11e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	85	3.23e-05	0.261000	2.59e-03
Regulation of RUNX1 Expression and Activity	17	6.28e-02	0.261000	2.81e-01
Platelet degranulation	88	2.87e-05	0.258000	2.43e-03
Signaling by RAF1 mutants	34	9.22e-03	0.258000	1.09e-01
Response of Mtb to phagocytosis	18	6.05e-02	0.256000	2.75e-01
Defective B3GALTL causes PpS	26	2.46e-02	0.255000	1.72e-01
Role of phospholipids in phagocytosis	32	1.30e-02	0.254000	1.32e-01
Diseases associated with O-glycosylation of proteins	41	5.14e-03	0.253000	7.42e-02
Dopamine Neurotransmitter Release Cycle	19	5.81e-02	-0.251000	2.72e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	35	1.09e-02	0.249000	1.21e-01
Signaling by RAS mutants	35	1.09e-02	0.249000	1.21e-01
Signaling by moderate kinase activity BRAF mutants	35	1.09e-02	0.249000	1.21e-01
Signaling downstream of RAS mutants	35	1.09e-02	0.249000	1.21e-01
Regulated proteolysis of p75NTR	11	1.55e-01	0.248000	4.51e-01
Rap1 signalling	12	1.38e-01	0.247000	4.21e-01
Antimicrobial peptides	18	7.00e-02	0.247000	2.94e-01
Nucleotide biosynthesis	10	1.77e-01	0.246000	4.87e-01
GAB1 signalosome	13	1.27e-01	0.245000	3.99e-01
FOXO-mediated transcription of cell death genes	14	1.14e-01	-0.244000	3.79e-01
MET activates RAP1 and RAC1	10	1.82e-01	0.243000	4.94e-01
Anchoring fibril formation	12	1.45e-01	0.243000	4.35e-01
Insulin receptor recycling	22	4.90e-02	-0.242000	2.44e-01
RUNX2 regulates osteoblast differentiation	20	6.07e-02	0.242000	2.75e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	10	1.86e-01	0.242000	4.97e-01
CRMPs in Sema3A signaling	15	1.06e-01	0.241000	3.64e-01
Amyloid fiber formation	42	6.96e-03	0.241000	9.13e-02
Cell recruitment (pro-inflammatory response)	21	5.89e-02	0.238000	2.72e-01
Purinergic signaling in leishmaniasis infection	21	5.89e-02	0.238000	2.72e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	12	1.53e-01	0.238000	4.48e-01
Response to elevated platelet cytosolic Ca2+	93	7.65e-05	0.238000	5.25e-03
Sealing of the nuclear envelope (NE) by ESCRT-III	22	5.46e-02	0.237000	2.59e-01
Vpr-mediated nuclear import of PICs	33	1.97e-02	-0.235000	1.57e-01
Semaphorin interactions	56	2.41e-03	0.235000	5.20e-02
Cross-presentation of soluble exogenous antigens (endosomes)	43	7.90e-03	0.234000	9.77e-02
Sema3A PAK dependent Axon repulsion	15	1.18e-01	0.233000	3.83e-01
Regulation of Complement cascade	34	1.89e-02	0.233000	1.56e-01
Signaling by ALK fusions and activated point mutants	50	4.56e-03	0.232000	6.95e-02
Signaling by ALK in cancer	50	4.56e-03	0.232000	6.95e-02
Glycogen synthesis	11	1.83e-01	0.232000	4.94e-01
RHO GTPases activate PKNs	32	2.36e-02	0.231000	1.67e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	71	8.13e-04	0.230000	3.01e-02
Eukaryotic Translation Elongation	67	1.15e-03	0.230000	3.93e-02
Cardiogenesis	19	8.28e-02	0.230000	3.26e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	45	7.88e-03	0.229000	9.77e-02
NPAS4 regulates expression of target genes	16	1.13e-01	-0.229000	3.77e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	1.14e-01	0.229000	3.78e-01
Negative regulation of NOTCH4 signaling	46	7.42e-03	0.228000	9.47e-02
Caspase activation via extrinsic apoptotic signalling pathway	22	6.49e-02	0.227000	2.87e-01
Formation of paraxial mesoderm	60	2.52e-03	0.226000	5.30e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	1.96e-01	0.225000	5.14e-01
Post-translational protein phosphorylation	76	7.53e-04	0.224000	2.90e-02
Formation of a pool of free 40S subunits	76	7.63e-04	0.224000	2.90e-02
Regulation of actin dynamics for phagocytic cup formation	61	2.57e-03	0.223000	5.30e-02
Binding and Uptake of Ligands by Scavenger Receptors	43	1.19e-02	0.222000	1.24e-01
Complement cascade	39	1.68e-02	0.221000	1.52e-01
EPHA-mediated growth cone collapse	25	5.54e-02	-0.221000	2.61e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	3.72e-02	-0.220000	2.17e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	3.72e-02	-0.220000	2.17e-01
Arachidonic acid metabolism	37	2.09e-02	0.220000	1.60e-01
Elastic fibre formation	38	1.95e-02	0.219000	1.57e-01
Signaling by BMP	21	8.24e-02	0.219000	3.26e-01
Role of LAT2/NTAL/LAB on calcium mobilization	23	6.92e-02	0.219000	2.94e-01
Regulation of TP53 Activity through Association with Co-factors	13	1.72e-01	0.219000	4.80e-01
Signaling by FGFR4 in disease	10	2.33e-01	0.218000	5.59e-01
SUMOylation of chromatin organization proteins	54	5.73e-03	-0.217000	8.03e-02
Mitochondrial calcium ion transport	18	1.12e-01	0.216000	3.77e-01
Adrenaline,noradrenaline inhibits insulin secretion	18	1.13e-01	-0.216000	3.77e-01
Adherens junctions interactions	52	7.12e-03	0.216000	9.25e-02
Neurotransmitter release cycle	37	2.31e-02	-0.216000	1.65e-01
Peptide chain elongation	64	2.86e-03	0.216000	5.57e-02
Transport of the SLBP independent Mature mRNA	34	2.96e-02	-0.216000	1.90e-01
Viral mRNA Translation	64	2.94e-03	0.215000	5.59e-02
Glutamate Neurotransmitter Release Cycle	19	1.05e-01	-0.215000	3.64e-01
PI-3K cascade:FGFR1	15	1.53e-01	0.213000	4.47e-01
SCF-beta-TrCP mediated degradation of Emi1	48	1.06e-02	0.213000	1.21e-01
Eukaryotic Translation Termination	67	2.64e-03	0.213000	5.30e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	53	7.49e-03	0.212000	9.48e-02
Diseases of programmed cell death	44	1.51e-02	0.212000	1.45e-01
Retrograde neurotrophin signalling	13	1.87e-01	-0.212000	4.97e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	12	2.05e-01	0.211000	5.21e-01
Selenocysteine synthesis	68	2.61e-03	0.211000	5.30e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.73e-01	0.211000	4.80e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	87	7.23e-04	0.210000	2.90e-02
Interleukin-15 signaling	10	2.50e-01	0.210000	5.73e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	25	6.98e-02	0.210000	2.94e-01
RHO GTPases Activate ROCKs	16	1.47e-01	0.209000	4.37e-01
Interactions of Vpr with host cellular proteins	34	3.48e-02	-0.209000	2.09e-01
Aquaporin-mediated transport	25	7.09e-02	-0.209000	2.95e-01
Transport of the SLBP Dependant Mature mRNA	35	3.27e-02	-0.209000	1.98e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	1.51e-01	0.208000	4.43e-01
G beta:gamma signalling through CDC42	11	2.34e-01	0.207000	5.59e-01
Nuclear events mediated by NFE2L2	69	3.01e-03	0.207000	5.62e-02
L13a-mediated translational silencing of Ceruloplasmin expression	86	9.52e-04	0.206000	3.35e-02
Interleukin-4 and Interleukin-13 signaling	78	1.67e-03	0.206000	4.36e-02
MAPK6/MAPK4 signaling	78	1.68e-03	0.206000	4.36e-02
FOXO-mediated transcription of cell cycle genes	17	1.43e-01	-0.205000	4.32e-01
Regulation of Expression and Function of Type II Classical Cadherins	31	4.80e-02	0.205000	2.40e-01
Regulation of Homotypic Cell-Cell Adhesion	31	4.80e-02	0.205000	2.40e-01
ROS and RNS production in phagocytes	26	7.08e-02	-0.205000	2.95e-01
Formation of the ternary complex, and subsequently, the 43S complex	39	2.72e-02	0.205000	1.82e-01
p75NTR signals via NF-kB	13	2.02e-01	0.205000	5.20e-01
Fcgamma receptor (FCGR) dependent phagocytosis	83	1.30e-03	0.204000	4.26e-02
Amine ligand-binding receptors	17	1.45e-01	-0.204000	4.35e-01
Diseases associated with the TLR signaling cascade	21	1.05e-01	0.204000	3.64e-01
Diseases of Immune System	21	1.05e-01	0.204000	3.64e-01
Formation of the cornified envelope	31	4.91e-02	0.204000	2.44e-01
Condensation of Prophase Chromosomes	19	1.23e-01	0.204000	3.92e-01
FCERI mediated Ca+2 mobilization	35	3.73e-02	0.203000	2.17e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	4.68e-02	-0.203000	2.39e-01
mTORC1-mediated signalling	20	1.16e-01	-0.203000	3.83e-01
Signaling by EGFR	42	2.32e-02	0.203000	1.65e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	4.76e-02	-0.202000	2.39e-01
Sensory perception of taste	17	1.49e-01	0.202000	4.41e-01
RHOBTB2 GTPase cycle	22	1.03e-01	0.201000	3.62e-01
Biotin transport and metabolism	11	2.49e-01	0.201000	5.71e-01
Formation of ATP by chemiosmotic coupling	15	1.79e-01	-0.200000	4.90e-01
Regulation of RUNX3 expression and activity	46	1.90e-02	0.200000	1.56e-01
Citric acid cycle (TCA cycle)	22	1.05e-01	-0.200000	3.64e-01
ALK mutants bind TKIs	11	2.53e-01	0.199000	5.73e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	8.54e-02	-0.199000	3.29e-01
Purine salvage	11	2.54e-01	0.198000	5.76e-01
Autodegradation of the E3 ubiquitin ligase COP1	45	2.15e-02	0.198000	1.64e-01
eNOS activation	11	2.58e-01	-0.197000	5.81e-01
Activation of gene expression by SREBF (SREBP)	41	2.91e-02	0.197000	1.89e-01
Kinesins	49	1.72e-02	0.197000	1.54e-01
Repression of WNT target genes	14	2.04e-01	-0.196000	5.21e-01
GRB2 events in ERBB2 signaling	12	2.40e-01	-0.196000	5.63e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	43	2.65e-02	0.196000	1.79e-01
Rev-mediated nuclear export of HIV RNA	35	4.60e-02	-0.195000	2.38e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	68	5.67e-03	0.194000	8.02e-02
Vif-mediated degradation of APOBEC3G	48	2.06e-02	0.193000	1.59e-01
Transferrin endocytosis and recycling	22	1.17e-01	-0.193000	3.83e-01
Glycogen metabolism	22	1.18e-01	0.193000	3.83e-01
SUMOylation of ubiquitinylation proteins	36	4.57e-02	-0.193000	2.38e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	75	4.14e-03	0.192000	6.78e-02
Formation of tubulin folding intermediates by CCT/TriC	19	1.48e-01	0.192000	4.40e-01
SCF(Skp2)-mediated degradation of p27/p21	51	1.80e-02	0.192000	1.56e-01
Spry regulation of FGF signaling	13	2.35e-01	0.190000	5.59e-01
Cap-dependent Translation Initiation	93	1.53e-03	0.190000	4.36e-02
Eukaryotic Translation Initiation	93	1.53e-03	0.190000	4.36e-02
Laminin interactions	25	1.00e-01	0.190000	3.57e-01
DCC mediated attractive signaling	13	2.36e-01	0.190000	5.60e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	48	2.30e-02	0.190000	1.65e-01
Lewis blood group biosynthesis	11	2.77e-01	-0.189000	6.01e-01
RHOF GTPase cycle	37	4.62e-02	0.189000	2.38e-01
Ubiquitin-dependent degradation of Cyclin D	46	2.65e-02	0.189000	1.79e-01
InlB-mediated entry of Listeria monocytogenes into host cell	13	2.39e-01	0.189000	5.63e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	80	3.56e-03	0.189000	6.33e-02
Erythropoietin activates RAS	11	2.79e-01	-0.189000	6.02e-01
Regulation of gene expression by Hypoxia-inducible Factor	10	3.02e-01	0.189000	6.29e-01
Nuclear Pore Complex (NPC) Disassembly	36	5.08e-02	-0.188000	2.50e-01
Selenoamino acid metabolism	90	2.06e-03	0.188000	4.71e-02
FLT3 Signaling	30	7.47e-02	0.188000	3.07e-01
Pyroptosis	17	1.82e-01	0.187000	4.94e-01
Regulation of FZD by ubiquitination	18	1.71e-01	0.187000	4.78e-01
Vpu mediated degradation of CD4	45	3.07e-02	0.186000	1.93e-01
Aflatoxin activation and detoxification	12	2.64e-01	-0.186000	5.87e-01
Retinoid metabolism and transport	29	8.36e-02	0.186000	3.26e-01
The canonical retinoid cycle in rods (twilight vision)	19	1.62e-01	0.186000	4.59e-01
ER-Phagosome pathway	77	4.97e-03	0.185000	7.32e-02
RHO GTPases Activate WASPs and WAVEs	31	7.49e-02	0.185000	3.07e-01
SRP-dependent cotranslational protein targeting to membrane	86	3.15e-03	0.184000	5.67e-02
Blood group systems biosynthesis	14	2.33e-01	-0.184000	5.59e-01
ADP signalling through P2Y purinoceptor 12	13	2.51e-01	0.184000	5.73e-01
Bacterial Infection Pathways	56	1.75e-02	0.184000	1.55e-01
Regulation of CDH11 function	11	2.92e-01	0.183000	6.17e-01
Myogenesis	23	1.29e-01	0.183000	4.04e-01
Interactions of Rev with host cellular proteins	36	5.83e-02	-0.182000	2.72e-01
Ribosomal scanning and start codon recognition	46	3.26e-02	0.182000	1.98e-01
Regulation of ornithine decarboxylase (ODC)	47	3.08e-02	0.182000	1.93e-01
RHOU GTPase cycle	38	5.30e-02	0.182000	2.56e-01
Retrograde transport at the Trans-Golgi-Network	48	2.98e-02	-0.181000	1.90e-01
Fatty acyl-CoA biosynthesis	30	8.58e-02	0.181000	3.29e-01
Diseases of glycosylation	106	1.30e-03	0.181000	4.26e-02
Inactivation, recovery and regulation of the phototransduction cascade	17	1.96e-01	0.181000	5.14e-01
Sema4D in semaphorin signaling	21	1.52e-01	0.181000	4.45e-01
Gene Silencing by RNA	82	4.86e-03	-0.180000	7.23e-02
RA biosynthesis pathway	16	2.13e-01	-0.180000	5.32e-01
Antigen processing-Cross presentation	87	3.79e-03	0.180000	6.44e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	49	3.01e-02	0.179000	1.91e-01
IKK complex recruitment mediated by RIP1	18	1.90e-01	0.178000	5.03e-01
FCGR3A-mediated phagocytosis	58	1.89e-02	0.178000	1.56e-01
Leishmania phagocytosis	58	1.89e-02	0.178000	1.56e-01
Parasite infection	58	1.89e-02	0.178000	1.56e-01
Regulated Necrosis	40	5.15e-02	0.178000	2.51e-01
Sensory processing of sound by inner hair cells of the cochlea	47	3.50e-02	-0.178000	2.09e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.40e-01	0.178000	4.28e-01
Triglyceride metabolism	26	1.17e-01	-0.178000	3.83e-01
Autodegradation of Cdh1 by Cdh1:APC/C	55	2.32e-02	0.177000	1.65e-01
Peptide ligand-binding receptors	90	3.75e-03	0.177000	6.44e-02
Stabilization of p53	49	3.23e-02	0.177000	1.98e-01
Vasopressin regulates renal water homeostasis via Aquaporins	24	1.35e-01	-0.176000	4.14e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	65	1.42e-02	0.176000	1.41e-01
Cell surface interactions at the vascular wall	98	2.64e-03	0.176000	5.30e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	46	3.92e-02	0.176000	2.18e-01
p53-Independent DNA Damage Response	46	3.92e-02	0.176000	2.18e-01
p53-Independent G1/S DNA damage checkpoint	46	3.92e-02	0.176000	2.18e-01
Acetylcholine Neurotransmitter Release Cycle	12	2.92e-01	-0.176000	6.17e-01
Interleukin-35 Signalling	10	3.37e-01	0.176000	6.69e-01
RHO GTPases activate PAKs	18	1.98e-01	0.175000	5.19e-01
Glycogen storage diseases	12	2.94e-01	0.175000	6.19e-01
XBP1(S) activates chaperone genes	43	4.72e-02	0.175000	2.39e-01
Regulation of CDH11 Expression and Function	28	1.10e-01	0.175000	3.72e-01
Glutathione synthesis and recycling	12	2.95e-01	0.175000	6.19e-01
Trafficking of GluR2-containing AMPA receptors	17	2.13e-01	-0.175000	5.32e-01
Export of Viral Ribonucleoproteins from Nucleus	33	8.27e-02	-0.175000	3.26e-01
Regulation of Apoptosis	46	4.07e-02	0.175000	2.20e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	46	4.11e-02	0.174000	2.20e-01
Translation initiation complex formation	46	4.11e-02	0.174000	2.20e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	27	1.18e-01	-0.174000	3.83e-01
Trafficking of AMPA receptors	27	1.18e-01	-0.174000	3.83e-01
RHO GTPases activate CIT	16	2.29e-01	0.174000	5.57e-01
Platelet sensitization by LDL	14	2.62e-01	0.173000	5.85e-01
Signaling by WNT in cancer	33	8.52e-02	0.173000	3.29e-01
Aspartate and asparagine metabolism	10	3.43e-01	-0.173000	6.75e-01
GLI3 is processed to GLI3R by the proteasome	51	3.27e-02	0.173000	1.98e-01
SUMOylation of DNA damage response and repair proteins	66	1.56e-02	-0.172000	1.45e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	86	5.90e-03	0.172000	8.11e-02
Nonsense-Mediated Decay (NMD)	86	5.90e-03	0.172000	8.11e-02
Synthesis of glycosylphosphatidylinositol (GPI)	15	2.49e-01	0.172000	5.71e-01
Glycogen breakdown (glycogenolysis)	14	2.66e-01	0.172000	5.88e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	68	1.47e-02	0.171000	1.42e-01
Neutrophil degranulation	351	4.30e-08	0.171000	6.90e-06
RIPK1-mediated regulated necrosis	23	1.56e-01	0.171000	4.52e-01
Regulation of necroptotic cell death	23	1.56e-01	0.171000	4.52e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	2.52e-01	-0.171000	5.73e-01
Ras activation upon Ca2+ influx through NMDA receptor	17	2.23e-01	-0.171000	5.48e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	6.22e-02	-0.171000	2.80e-01
Budding and maturation of HIV virion	22	1.67e-01	0.170000	4.70e-01
Interaction between L1 and Ankyrins	26	1.33e-01	-0.170000	4.10e-01
KEAP1-NFE2L2 pathway	93	4.57e-03	0.170000	6.95e-02
Lysine catabolism	11	3.29e-01	-0.170000	6.62e-01
Signaling by FGFR3	32	9.68e-02	0.170000	3.49e-01
Signaling by FGFR1	40	6.37e-02	0.170000	2.84e-01
Platelet Adhesion to exposed collagen	11	3.31e-01	0.169000	6.65e-01
Platelet activation, signaling and aggregation	193	5.52e-05	0.169000	3.98e-03
Signaling by MET	69	1.57e-02	0.168000	1.45e-01
Beta-oxidation of very long chain fatty acids	11	3.35e-01	0.168000	6.67e-01
Disorders of Developmental Biology	10	3.58e-01	0.168000	6.79e-01
Disorders of Nervous System Development	10	3.58e-01	0.168000	6.79e-01
Loss of function of MECP2 in Rett syndrome	10	3.58e-01	0.168000	6.79e-01
Pervasive developmental disorders	10	3.58e-01	0.168000	6.79e-01
Downstream signaling of activated FGFR1	24	1.57e-01	0.167000	4.53e-01
Maturation of spike protein 9694548	35	8.75e-02	0.167000	3.34e-01
WNT ligand biogenesis and trafficking	21	1.86e-01	-0.167000	4.97e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	67	1.86e-02	0.166000	1.56e-01
Degradation of DVL	50	4.22e-02	0.166000	2.22e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	6.67e-02	-0.166000	2.93e-01
Plasma lipoprotein remodeling	23	1.70e-01	0.165000	4.78e-01
Diseases associated with glycosaminoglycan metabolism	34	9.61e-02	0.165000	3.48e-01
Signaling by NOTCH4	72	1.57e-02	0.165000	1.45e-01
Transport of bile salts and organic acids, metal ions and amine compounds	64	2.32e-02	-0.164000	1.65e-01
Olfactory Signaling Pathway	21	1.93e-01	0.164000	5.08e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	19	2.17e-01	0.164000	5.39e-01
Apoptotic cleavage of cellular proteins	33	1.05e-01	0.163000	3.64e-01
Interleukin-1 signaling	95	6.11e-03	0.163000	8.32e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	57	3.37e-02	0.163000	2.03e-01
NS1 Mediated Effects on Host Pathways	38	8.38e-02	-0.162000	3.26e-01
Cellular response to hypoxia	65	2.40e-02	0.162000	1.69e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	15	2.78e-01	0.162000	6.02e-01
RET signaling	37	9.00e-02	0.161000	3.39e-01
Regulation of PTEN mRNA translation	11	3.56e-01	0.161000	6.79e-01
Plasma lipoprotein assembly	11	3.56e-01	0.161000	6.79e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	91	8.16e-03	-0.161000	9.98e-02
Interleukin-37 signaling	17	2.53e-01	-0.160000	5.73e-01
Regulation of PLK1 Activity at G2/M Transition	78	1.47e-02	0.160000	1.42e-01
Mitochondrial protein import	56	3.93e-02	-0.159000	2.18e-01
Regulation of APC/C activators between G1/S and early anaphase	71	2.05e-02	0.159000	1.59e-01
NR1H2 and NR1H3-mediated signaling	35	1.03e-01	0.159000	3.63e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	3.61e-01	0.159000	6.82e-01
Centrosome maturation	73	1.96e-02	0.158000	1.57e-01
Recruitment of mitotic centrosome proteins and complexes	73	1.96e-02	0.158000	1.57e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	27	1.56e-01	0.158000	4.52e-01
Negative regulation of MET activity	18	2.47e-01	0.158000	5.71e-01
Asymmetric localization of PCP proteins	57	3.99e-02	0.157000	2.18e-01
APC/C:Cdc20 mediated degradation of Securin	59	3.74e-02	0.157000	2.17e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	65	2.90e-02	0.157000	1.89e-01
p53-Dependent G1 DNA Damage Response	58	3.92e-02	0.157000	2.18e-01
p53-Dependent G1/S DNA damage checkpoint	58	3.92e-02	0.157000	2.18e-01
Interleukin-6 signaling	11	3.70e-01	0.156000	6.90e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	3.32e-01	0.155000	6.65e-01
RAC3 GTPase cycle	81	1.57e-02	0.155000	1.45e-01
Signaling by cytosolic FGFR1 fusion mutants	16	2.82e-01	0.155000	6.06e-01
Deadenylation of mRNA	21	2.19e-01	-0.155000	5.40e-01
TAK1-dependent IKK and NF-kappa-B activation	36	1.09e-01	0.154000	3.72e-01
Downstream signaling of activated FGFR2	23	2.01e-01	0.154000	5.20e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	3.19e-01	0.154000	6.54e-01
SUMOylation of SUMOylation proteins	34	1.21e-01	-0.154000	3.89e-01
Downstream signaling of activated FGFR3	20	2.35e-01	0.154000	5.59e-01
Nuclear import of Rev protein	33	1.27e-01	-0.154000	3.99e-01
SUMOylation of RNA binding proteins	45	7.49e-02	-0.154000	3.07e-01
PI-3K cascade:FGFR2	17	2.74e-01	0.153000	5.97e-01
Signal amplification	22	2.15e-01	0.153000	5.35e-01
COPI-dependent Golgi-to-ER retrograde traffic	86	1.44e-02	0.153000	1.42e-01
NCAM1 interactions	35	1.19e-01	0.153000	3.83e-01
Cyclin A:Cdk2-associated events at S phase entry	76	2.18e-02	0.152000	1.65e-01
PI-3K cascade:FGFR3	14	3.24e-01	0.152000	6.57e-01
Activation of HOX genes during differentiation	60	4.15e-02	0.152000	2.20e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	60	4.15e-02	0.152000	2.20e-01
CaM pathway	27	1.71e-01	-0.152000	4.78e-01
Calmodulin induced events	27	1.71e-01	-0.152000	4.78e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	14	3.25e-01	0.152000	6.58e-01
Hyaluronan uptake and degradation	10	4.06e-01	0.152000	7.21e-01
TGF-beta receptor signaling activates SMADs	37	1.11e-01	0.152000	3.75e-01
Metabolism of fat-soluble vitamins	33	1.33e-01	0.151000	4.10e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	27	1.74e-01	0.151000	4.82e-01
Protein methylation	13	3.46e-01	0.151000	6.76e-01
Carboxyterminal post-translational modifications of tubulin	31	1.46e-01	-0.151000	4.36e-01
Ion transport by P-type ATPases	40	9.89e-02	-0.151000	3.55e-01
AURKA Activation by TPX2	66	3.52e-02	0.150000	2.09e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	13	3.49e-01	0.150000	6.76e-01
Digestion	14	3.33e-01	0.150000	6.66e-01
APC/C-mediated degradation of cell cycle proteins	78	2.25e-02	0.150000	1.65e-01
Regulation of mitotic cell cycle	78	2.25e-02	0.150000	1.65e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	64	3.87e-02	0.150000	2.18e-01
The phototransduction cascade	18	2.73e-01	0.149000	5.97e-01
Molecules associated with elastic fibres	32	1.45e-01	0.149000	4.35e-01
Signaling by NTRK3 (TRKC)	16	3.03e-01	0.149000	6.30e-01
HIV Transcription Initiation	43	9.19e-02	-0.149000	3.39e-01
RNA Polymerase II HIV Promoter Escape	43	9.19e-02	-0.149000	3.39e-01
RNA Polymerase II Promoter Escape	43	9.19e-02	-0.149000	3.39e-01
RNA Polymerase II Transcription Initiation	43	9.19e-02	-0.149000	3.39e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	9.19e-02	-0.149000	3.39e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	9.19e-02	-0.149000	3.39e-01
VLDLR internalisation and degradation	13	3.54e-01	0.149000	6.79e-01
Attachment and Entry 9694614	13	3.54e-01	0.148000	6.79e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	65	3.87e-02	0.148000	2.18e-01
Downstream signal transduction	26	1.91e-01	0.148000	5.03e-01
NOTCH1 Intracellular Domain Regulates Transcription	42	9.66e-02	-0.148000	3.49e-01
Regulation of PTEN stability and activity	60	4.74e-02	0.148000	2.39e-01
FCGR activation	18	2.77e-01	0.148000	6.01e-01
Regulation of MECP2 expression and activity	27	1.84e-01	0.148000	4.95e-01
Cyclin E associated events during G1/S transition	74	2.83e-02	0.148000	1.86e-01
Regulation of RAS by GAPs	59	5.02e-02	0.148000	2.48e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	2.03e-01	-0.147000	5.21e-01
Metabolism of folate and pterines	13	3.59e-01	-0.147000	6.79e-01
O-linked glycosylation of mucins	39	1.13e-01	-0.147000	3.77e-01
Degradation of GLI1 by the proteasome	51	7.01e-02	0.147000	2.94e-01
Apoptotic execution phase	42	1.00e-01	0.147000	3.57e-01
Recognition of DNA damage by PCNA-containing replication complex	23	2.25e-01	-0.146000	5.52e-01
Aspirin ADME	10	4.24e-01	0.146000	7.33e-01
RHOJ GTPase cycle	48	8.03e-02	0.146000	3.21e-01
PECAM1 interactions	11	4.02e-01	0.146000	7.20e-01
SLC transporter disorders	76	2.80e-02	-0.146000	1.85e-01
Insulin processing	20	2.59e-01	-0.146000	5.83e-01
Transcriptional regulation by RUNX3	83	2.20e-02	0.146000	1.65e-01
Dermatan sulfate biosynthesis	10	4.26e-01	0.145000	7.35e-01
Amino acids regulate mTORC1	40	1.12e-01	-0.145000	3.77e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	3.84e-01	0.145000	7.02e-01
Zinc transporters	11	4.06e-01	0.145000	7.21e-01
Plasma lipoprotein clearance	28	1.88e-01	0.144000	4.99e-01
Cargo concentration in the ER	23	2.33e-01	0.144000	5.59e-01
Pregnenolone biosynthesis	11	4.11e-01	-0.143000	7.23e-01
HDMs demethylate histones	22	2.46e-01	-0.143000	5.71e-01
Cell-Cell communication	127	5.56e-03	0.143000	7.94e-02
Signaling by CSF1 (M-CSF) in myeloid cells	26	2.10e-01	0.142000	5.27e-01
FCERI mediated NF-kB activation	77	3.12e-02	0.142000	1.94e-01
TCR signaling	86	2.32e-02	0.142000	1.65e-01
IRAK1 recruits IKK complex	11	4.17e-01	-0.141000	7.28e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	11	4.17e-01	-0.141000	7.28e-01
Sensory processing of sound	53	7.55e-02	-0.141000	3.07e-01
Activation of RAC1	10	4.39e-01	0.141000	7.46e-01
PCP/CE pathway	80	2.92e-02	0.141000	1.89e-01
Viral Messenger RNA Synthesis	44	1.06e-01	-0.141000	3.65e-01
MTOR signalling	36	1.44e-01	-0.141000	4.35e-01
IRE1alpha activates chaperones	45	1.03e-01	0.141000	3.63e-01
RHO GTPases Activate Formins	121	7.92e-03	0.140000	9.77e-02
Mucopolysaccharidoses	11	4.22e-01	0.140000	7.33e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	12	4.03e-01	0.139000	7.20e-01
RHO GTPases activate IQGAPs	24	2.38e-01	0.139000	5.63e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	4.05e-01	-0.139000	7.21e-01
Long-term potentiation	20	2.84e-01	-0.139000	6.08e-01
Pre-NOTCH Transcription and Translation	39	1.36e-01	0.138000	4.15e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	13	3.89e-01	0.138000	7.02e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	13	3.89e-01	0.138000	7.02e-01
Tight junction interactions	18	3.10e-01	-0.138000	6.41e-01
Digestion and absorption	17	3.25e-01	0.138000	6.58e-01
Fc epsilon receptor (FCERI) signaling	120	9.29e-03	0.138000	1.09e-01
Transmission across Chemical Synapses	195	9.45e-04	-0.138000	3.35e-02
Metabolism of porphyrins	24	2.44e-01	0.138000	5.70e-01
Loss of Nlp from mitotic centrosomes	63	5.95e-02	0.137000	2.74e-01
Loss of proteins required for interphase microtubule organization from the centrosome	63	5.95e-02	0.137000	2.74e-01
Activation of NMDA receptors and postsynaptic events	76	3.88e-02	-0.137000	2.18e-01
Degradation of GLI2 by the proteasome	51	9.06e-02	0.137000	3.39e-01
SARS-CoV-1 modulates host translation machinery	24	2.46e-01	0.137000	5.71e-01
Degradation of AXIN	48	1.01e-01	0.137000	3.59e-01
Signaling by ROBO receptors	172	2.01e-03	0.137000	4.69e-02
Prostacyclin signalling through prostacyclin receptor	10	4.55e-01	0.136000	7.57e-01
Signaling by TGFB family members	101	1.81e-02	0.136000	1.56e-01
tRNA processing in the nucleus	57	7.54e-02	-0.136000	3.07e-01
Signaling by PDGFRA extracellular domain mutants	11	4.34e-01	0.136000	7.41e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	11	4.34e-01	0.136000	7.41e-01
Visual phototransduction	64	5.99e-02	0.136000	2.75e-01
PKA activation in glucagon signalling	12	4.15e-01	-0.136000	7.27e-01
Activation of NF-kappaB in B cells	57	7.65e-02	0.136000	3.10e-01
RUNX2 regulates bone development	26	2.31e-01	0.136000	5.59e-01
Purine catabolism	15	3.63e-01	-0.136000	6.85e-01
MyD88-independent TLR4 cascade	92	2.48e-02	0.136000	1.72e-01
TRIF(TICAM1)-mediated TLR4 signaling	92	2.48e-02	0.136000	1.72e-01
Signaling by FGFR1 in disease	30	1.99e-01	0.135000	5.19e-01
G1/S DNA Damage Checkpoints	60	6.98e-02	0.135000	2.94e-01
Interleukin-1 family signaling	121	1.02e-02	0.135000	1.19e-01
Cell junction organization	96	2.22e-02	0.135000	1.65e-01
Branched-chain amino acid catabolism	20	2.95e-01	0.135000	6.19e-01
Post NMDA receptor activation events	63	6.44e-02	-0.135000	2.86e-01
Beta-catenin independent WNT signaling	119	1.14e-02	0.135000	1.22e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	104	1.82e-02	-0.134000	1.56e-01
G2/M Transition	175	2.24e-03	0.134000	4.98e-02
Signaling by FGFR	73	4.76e-02	0.134000	2.39e-01
Mitotic G2-G2/M phases	177	2.29e-03	0.133000	5.02e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	30	2.07e-01	0.133000	5.25e-01
Basigin interactions	21	2.92e-01	0.133000	6.17e-01
CTNNB1 S33 mutants aren’t phosphorylated	15	3.73e-01	0.133000	6.90e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	3.73e-01	0.133000	6.90e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	3.73e-01	0.133000	6.90e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	3.73e-01	0.133000	6.90e-01
Signaling by CTNNB1 phospho-site mutants	15	3.73e-01	0.133000	6.90e-01
Signaling by GSK3beta mutants	15	3.73e-01	0.133000	6.90e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	11	4.46e-01	0.133000	7.49e-01
Defective EXT2 causes exostoses 2	11	4.46e-01	0.133000	7.49e-01
Formation of WDR5-containing histone-modifying complexes	36	1.69e-01	-0.132000	4.76e-01
Energy dependent regulation of mTOR by LKB1-AMPK	25	2.52e-01	-0.132000	5.73e-01
RHOB GTPase cycle	64	6.84e-02	0.132000	2.94e-01
Signaling by FGFR4	31	2.04e-01	0.132000	5.21e-01
Elevation of cytosolic Ca2+ levels	12	4.31e-01	0.131000	7.39e-01
RAS processing	18	3.35e-01	-0.131000	6.67e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	28	2.29e-01	-0.131000	5.58e-01
Synthesis of PA	29	2.22e-01	0.131000	5.46e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	3.50e-01	-0.131000	6.76e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	3.50e-01	-0.131000	6.76e-01
Tie2 Signaling	15	3.80e-01	0.131000	6.98e-01
RAC1 GTPase cycle	159	4.46e-03	0.131000	6.95e-02
FOXO-mediated transcription	55	9.32e-02	-0.131000	3.42e-01
Interconversion of nucleotide di- and triphosphates	27	2.39e-01	0.131000	5.63e-01
Ca2+ pathway	46	1.25e-01	0.131000	3.96e-01
Leading Strand Synthesis	11	4.53e-01	-0.131000	7.57e-01
Polymerase switching	11	4.53e-01	-0.131000	7.57e-01
Negative regulation of FGFR1 signaling	24	2.68e-01	0.131000	5.89e-01
Activation of the pre-replicative complex	29	2.26e-01	-0.130000	5.52e-01
Reduction of cytosolic Ca++ levels	10	4.77e-01	-0.130000	7.80e-01
Respiratory electron transport	85	3.99e-02	-0.129000	2.18e-01
Activation of kainate receptors upon glutamate binding	19	3.33e-01	-0.128000	6.66e-01
Activated NTRK2 signals through FRS2 and FRS3	10	4.83e-01	0.128000	7.85e-01
Signaling by NOTCH3	43	1.46e-01	0.128000	4.36e-01
Cristae formation	27	2.49e-01	-0.128000	5.71e-01
Listeria monocytogenes entry into host cells	18	3.48e-01	0.128000	6.76e-01
Innate Immune System	718	8.48e-09	0.127000	1.75e-06
Downstream signaling of activated FGFR4	20	3.24e-01	0.127000	6.57e-01
Assembly of the pre-replicative complex	79	5.12e-02	0.127000	2.51e-01
Unblocking of NMDA receptors, glutamate binding and activation	19	3.39e-01	-0.127000	6.70e-01
Mitotic Metaphase and Anaphase	206	1.76e-03	0.127000	4.46e-02
Transcriptional Regulation by VENTX	36	1.89e-01	0.127000	5.00e-01
Hh mutants are degraded by ERAD	50	1.22e-01	0.127000	3.89e-01
Downstream TCR signaling	71	6.55e-02	0.127000	2.89e-01
Regulation of expression of SLITs and ROBOs	134	1.17e-02	0.126000	1.24e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	28	2.49e-01	0.126000	5.71e-01
Golgi-to-ER retrograde transport	119	1.78e-02	0.126000	1.56e-01
Hedgehog ligand biogenesis	58	9.77e-02	0.126000	3.52e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	92	3.75e-02	0.126000	2.17e-01
Toll Like Receptor TLR6:TLR2 Cascade	92	3.75e-02	0.126000	2.17e-01
Hyaluronan metabolism	15	4.01e-01	0.125000	7.19e-01
FRS-mediated FGFR1 signaling	16	3.86e-01	0.125000	7.02e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	19	3.45e-01	0.125000	6.76e-01
Signaling by FLT3 ITD and TKD mutants	14	4.17e-01	0.125000	7.28e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	67	7.71e-02	0.125000	3.12e-01
Activation of ATR in response to replication stress	35	2.02e-01	-0.125000	5.20e-01
Signaling by VEGF	90	4.15e-02	0.124000	2.20e-01
Interleukin receptor SHC signaling	19	3.48e-01	0.124000	6.76e-01
Mitotic Anaphase	205	2.23e-03	0.124000	4.98e-02
Striated Muscle Contraction	29	2.47e-01	0.124000	5.71e-01
Dectin-1 mediated noncanonical NF-kB signaling	52	1.22e-01	0.124000	3.90e-01
Recruitment of NuMA to mitotic centrosomes	81	5.43e-02	0.124000	2.59e-01
Fatty acid metabolism	139	1.20e-02	0.124000	1.24e-01
Gluconeogenesis	30	2.41e-01	0.124000	5.66e-01
Signaling by TGF-beta Receptor Complex	79	5.84e-02	0.123000	2.72e-01
ERBB2 Regulates Cell Motility	10	5.00e-01	-0.123000	7.94e-01
Downstream signaling events of B Cell Receptor (BCR)	70	7.50e-02	0.123000	3.07e-01
Oncogenic MAPK signaling	68	7.96e-02	0.123000	3.20e-01
Synthesis of very long-chain fatty acyl-CoAs	19	3.54e-01	0.123000	6.79e-01
Toll Like Receptor 2 (TLR2) Cascade	94	3.97e-02	0.123000	2.18e-01
Toll Like Receptor TLR1:TLR2 Cascade	94	3.97e-02	0.123000	2.18e-01
Drug ADME	52	1.27e-01	0.122000	3.99e-01
Sphingolipid de novo biosynthesis	39	1.86e-01	-0.122000	4.97e-01
Transcriptional regulation by RUNX2	107	2.91e-02	0.122000	1.89e-01
Unfolded Protein Response (UPR)	85	5.21e-02	0.122000	2.52e-01
Mitotic Prometaphase	182	4.81e-03	0.121000	7.22e-02
Defective CFTR causes cystic fibrosis	55	1.19e-01	0.121000	3.85e-01
Late endosomal microautophagy	28	2.67e-01	-0.121000	5.88e-01
Regulation of RUNX2 expression and activity	65	9.12e-02	0.121000	3.39e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	5.07e-01	-0.121000	8.04e-01
Metabolism of polyamines	55	1.21e-01	0.121000	3.89e-01
Assembly of the ORC complex at the origin of replication	14	4.34e-01	0.121000	7.41e-01
CDK-mediated phosphorylation and removal of Cdc6	64	9.54e-02	0.121000	3.47e-01
DARPP-32 events	21	3.39e-01	-0.121000	6.70e-01
FGFR1 mutant receptor activation	24	3.07e-01	0.120000	6.36e-01
RHO GTPase Effectors	232	1.65e-03	0.120000	4.36e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta	52	1.35e-01	0.120000	4.13e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	3.54e-01	0.120000	6.79e-01
Regulation of KIT signaling	16	4.07e-01	0.120000	7.21e-01
TNFR1-induced NF-kappa-B signaling pathway	29	2.65e-01	-0.120000	5.88e-01
Caspase activation via Dependence Receptors in the absence of ligand	10	5.13e-01	-0.120000	8.05e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	87	5.46e-02	0.119000	2.59e-01
Amplification of signal from the kinetochores	87	5.46e-02	0.119000	2.59e-01
Inwardly rectifying K+ channels	21	3.44e-01	0.119000	6.76e-01
Post-chaperonin tubulin folding pathway	16	4.09e-01	0.119000	7.21e-01
Hemostasis	447	1.90e-05	0.119000	1.83e-03
Separation of Sister Chromatids	167	8.30e-03	0.119000	1.01e-01
Complex I biogenesis	48	1.56e-01	-0.118000	4.52e-01
Peroxisomal lipid metabolism	27	2.89e-01	0.118000	6.15e-01
ATF6 (ATF6-alpha) activates chaperones	11	4.99e-01	-0.118000	7.94e-01
Leishmania infection	134	1.89e-02	0.118000	1.56e-01
Parasitic Infection Pathways	134	1.89e-02	0.118000	1.56e-01
Toll Like Receptor 4 (TLR4) Cascade	115	2.96e-02	0.118000	1.90e-01
PERK regulates gene expression	29	2.74e-01	0.117000	5.97e-01
G-protein activation	13	4.65e-01	-0.117000	7.65e-01
Translation	254	1.50e-03	0.116000	4.36e-02
Neurotransmitter receptors and postsynaptic signal transmission	149	1.46e-02	-0.116000	1.42e-01
RNA polymerase II transcribes snRNA genes	65	1.07e-01	-0.116000	3.65e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	4.70e-01	0.116000	7.71e-01
NOTCH2 intracellular domain regulates transcription	10	5.28e-01	0.115000	8.09e-01
Termination of translesion DNA synthesis	24	3.29e-01	-0.115000	6.63e-01
EML4 and NUDC in mitotic spindle formation	102	4.51e-02	0.115000	2.36e-01
Downregulation of ERBB2 signaling	23	3.40e-01	-0.115000	6.71e-01
SUMOylation of transcription factors	16	4.26e-01	0.115000	7.35e-01
The citric acid (TCA) cycle and respiratory electron transport	151	1.50e-02	-0.115000	1.45e-01
PI-3K cascade:FGFR4	14	4.57e-01	0.115000	7.58e-01
M Phase	326	4.03e-04	0.115000	2.00e-02
MyD88 dependent cascade initiated on endosome	85	6.85e-02	0.114000	2.94e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	85	6.85e-02	0.114000	2.94e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	85	6.85e-02	0.114000	2.94e-01
Thrombin signalling through proteinase activated receptors (PARs)	20	3.76e-01	-0.114000	6.94e-01
Negative regulation of FGFR2 signaling	25	3.22e-01	0.114000	6.57e-01
NIK–>noncanonical NF-kB signaling	51	1.58e-01	0.114000	4.54e-01
Apoptosis	148	1.69e-02	0.114000	1.52e-01
Protein folding	78	8.30e-02	0.114000	3.26e-01
Diseases associated with glycosylation precursor biosynthesis	13	4.78e-01	-0.114000	7.81e-01
Programmed Cell Death	168	1.14e-02	0.113000	1.22e-01
NOTCH3 Intracellular Domain Regulates Transcription	21	3.69e-01	0.113000	6.90e-01
IL-6-type cytokine receptor ligand interactions	15	4.47e-01	0.113000	7.50e-01
FCERI mediated MAPK activation	37	2.33e-01	0.113000	5.59e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	33	2.60e-01	0.113000	5.83e-01
Signaling by FGFR2	60	1.30e-01	0.113000	4.05e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	4.19e-01	0.113000	7.30e-01
The activation of arylsulfatases	11	5.18e-01	0.113000	8.05e-01
Transcriptional regulation of granulopoiesis	33	2.63e-01	0.113000	5.87e-01
TICAM1, RIP1-mediated IKK complex recruitment	14	4.66e-01	0.112000	7.67e-01
Toll Like Receptor 3 (TLR3) Cascade	88	6.89e-02	0.112000	2.94e-01
Interferon alpha/beta signaling	49	1.75e-01	0.112000	4.83e-01
Ion homeostasis	42	2.09e-01	-0.112000	5.27e-01
Uptake and actions of bacterial toxins	21	3.75e-01	0.112000	6.93e-01
Synthesis of PIPs at the early endosome membrane	15	4.54e-01	-0.112000	7.57e-01
TP53 Regulates Transcription of Cell Cycle Genes	45	1.95e-01	-0.112000	5.13e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	33	2.68e-01	0.112000	5.89e-01
Synthesis, secretion, and deacylation of Ghrelin	15	4.54e-01	-0.112000	7.57e-01
Cell-cell junction organization	71	1.05e-01	0.112000	3.64e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	44	2.02e-01	0.111000	5.20e-01
N-glycan antennae elongation in the medial/trans-Golgi	23	3.56e-01	-0.111000	6.79e-01
UCH proteinases	79	8.86e-02	0.111000	3.37e-01
Xenobiotics	10	5.44e-01	-0.111000	8.15e-01
Transcriptional Regulation by E2F6	31	2.86e-01	-0.111000	6.12e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	1.85e-01	0.111000	4.97e-01
Metabolism of cofactors	17	4.30e-01	-0.110000	7.39e-01
SARS-CoV-2 modulates host translation machinery	35	2.59e-01	0.110000	5.82e-01
CDC42 GTPase cycle	134	2.77e-02	0.110000	1.84e-01
ABC transporter disorders	68	1.16e-01	0.110000	3.83e-01
Polymerase switching on the C-strand of the telomere	22	3.71e-01	-0.110000	6.90e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	25	3.40e-01	0.110000	6.71e-01
Interleukin-6 family signaling	22	3.72e-01	0.110000	6.90e-01
Maturation of nucleoprotein 9694631	13	4.94e-01	-0.110000	7.92e-01
Chaperonin-mediated protein folding	73	1.06e-01	0.110000	3.64e-01
Signaling by BRAF and RAF1 fusions	55	1.61e-01	0.109000	4.59e-01
Resolution of Sister Chromatid Cohesion	111	4.76e-02	0.109000	2.39e-01
Ca-dependent events	29	3.10e-01	-0.109000	6.41e-01
Oncogene Induced Senescence	30	3.03e-01	0.109000	6.30e-01
Negative regulation of FGFR3 signaling	22	3.79e-01	0.108000	6.98e-01
G alpha (i) signalling events	185	1.13e-02	0.108000	1.22e-01
p75NTR recruits signalling complexes	11	5.34e-01	0.108000	8.15e-01
RNA Polymerase I Promoter Escape	36	2.62e-01	0.108000	5.85e-01
Cardiac conduction	97	6.62e-02	-0.108000	2.91e-01
MAPK3 (ERK1) activation	10	5.56e-01	0.108000	8.20e-01
Synthesis of substrates in N-glycan biosythesis	57	1.61e-01	0.107000	4.59e-01
SLC-mediated transmembrane transport	182	1.28e-02	-0.107000	1.31e-01
Signaling by FGFR in disease	53	1.78e-01	0.107000	4.89e-01
Signaling by Erythropoietin	20	4.08e-01	-0.107000	7.21e-01
Diseases associated with visual transduction	10	5.59e-01	0.107000	8.20e-01
Diseases of the neuronal system	10	5.59e-01	0.107000	8.20e-01
Retinoid cycle disease events	10	5.59e-01	0.107000	8.20e-01
Cytosolic iron-sulfur cluster assembly	12	5.22e-01	0.107000	8.07e-01
MHC class II antigen presentation	95	7.29e-02	0.107000	3.02e-01
mRNA decay by 5’ to 3’ exoribonuclease	14	4.91e-01	0.106000	7.92e-01
ABC-family proteins mediated transport	89	8.44e-02	0.106000	3.28e-01
Organic cation/anion/zwitterion transport	12	5.25e-01	-0.106000	8.08e-01
RHOD GTPase cycle	48	2.05e-01	0.106000	5.21e-01
Signaling by ALK	23	3.80e-01	0.106000	6.98e-01
Constitutive Signaling by EGFRvIII	14	4.94e-01	0.106000	7.92e-01
Signaling by EGFRvIII in Cancer	14	4.94e-01	0.106000	7.92e-01
Transport of connexons to the plasma membrane	13	5.10e-01	0.106000	8.05e-01
Plasma lipoprotein assembly, remodeling, and clearance	54	1.80e-01	0.106000	4.91e-01
TBC/RABGAPs	43	2.32e-01	-0.105000	5.59e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	5.64e-01	0.105000	8.22e-01
Keratan sulfate degradation	11	5.48e-01	0.105000	8.15e-01
SUMOylation of DNA methylation proteins	14	4.98e-01	-0.105000	7.94e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	16	4.70e-01	0.104000	7.71e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	16	4.70e-01	0.104000	7.71e-01
RHOA GTPase cycle	128	4.22e-02	0.104000	2.22e-01
Nuclear Envelope Breakdown	51	2.00e-01	-0.104000	5.19e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	5.36e-01	0.103000	8.15e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	13	5.20e-01	0.103000	8.05e-01
Regulation of gene expression in beta cells	11	5.54e-01	-0.103000	8.19e-01
Lysosphingolipid and LPA receptors	12	5.38e-01	0.103000	8.15e-01
Formation of definitive endoderm	11	5.56e-01	-0.102000	8.20e-01
Synthesis of bile acids and bile salts	24	3.85e-01	-0.102000	7.02e-01
Ion channel transport	128	4.65e-02	-0.102000	2.39e-01
Signaling by NOTCH2	28	3.51e-01	0.102000	6.78e-01
Neurexins and neuroligins	49	2.18e-01	-0.102000	5.40e-01
Assembly of active LPL and LIPC lipase complexes	14	5.10e-01	0.102000	8.05e-01
E2F mediated regulation of DNA replication	20	4.32e-01	-0.101000	7.40e-01
DNA Damage Bypass	39	2.75e-01	-0.101000	5.98e-01
SUMOylation of DNA replication proteins	44	2.47e-01	-0.101000	5.71e-01
Iron uptake and transport	44	2.48e-01	-0.101000	5.71e-01
Downregulation of ERBB2:ERBB3 signaling	11	5.63e-01	-0.101000	8.22e-01
Assembly Of The HIV Virion	12	5.46e-01	0.101000	8.15e-01
Hh mutants abrogate ligand secretion	52	2.11e-01	0.100000	5.30e-01
SIRT1 negatively regulates rRNA expression	14	5.16e-01	0.100000	8.05e-01
Diseases of metabolism	192	1.72e-02	0.099900	1.54e-01
Metabolism of steroids	119	6.06e-02	0.099700	2.75e-01
Autophagy	126	5.37e-02	-0.099700	2.58e-01
VEGFA-VEGFR2 Pathway	83	1.19e-01	0.099200	3.83e-01
Phase 4 - resting membrane potential	13	5.36e-01	-0.099000	8.15e-01
Association of TriC/CCT with target proteins during biosynthesis	37	2.98e-01	0.099000	6.22e-01
Class A/1 (Rhodopsin-like receptors)	160	3.12e-02	0.099000	1.94e-01
Interferon gamma signaling	59	1.89e-01	0.099000	5.00e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	34	3.20e-01	0.098500	6.55e-01
Signaling by Interleukins	343	1.81e-03	0.098500	4.49e-02
Immune System	1394	1.87e-09	0.098100	6.74e-07
Nucleotide salvage	19	4.60e-01	0.097900	7.61e-01
RND2 GTPase cycle	38	2.98e-01	0.097700	6.22e-01
G2/M DNA damage checkpoint	56	2.08e-01	0.097400	5.25e-01
Sialic acid metabolism	29	3.64e-01	0.097300	6.86e-01
Protein-protein interactions at synapses	76	1.43e-01	-0.097300	4.33e-01
Mitotic Spindle Checkpoint	101	9.22e-02	0.097100	3.39e-01
Interleukin-27 signaling	10	5.95e-01	0.097100	8.39e-01
Orc1 removal from chromatin	63	1.85e-01	0.096600	4.97e-01
AKT phosphorylates targets in the cytosol	13	5.48e-01	-0.096200	8.15e-01
Eicosanoid ligand-binding receptors	11	5.81e-01	0.096000	8.29e-01
VEGFR2 mediated cell proliferation	17	4.94e-01	0.095900	7.92e-01
RNA Polymerase III Transcription Termination	20	4.59e-01	0.095800	7.60e-01
Transcription of the HIV genome	64	1.86e-01	-0.095700	4.97e-01
Signaling by FGFR3 in disease	17	4.95e-01	0.095700	7.92e-01
CLEC7A (Dectin-1) signaling	84	1.31e-01	0.095500	4.06e-01
Axon guidance	467	4.54e-04	0.095300	2.11e-02
Cellular response to chemical stress	165	3.52e-02	0.095200	2.09e-01
Adaptive Immune System	585	9.66e-05	0.095100	6.34e-03
COPII-mediated vesicle transport	56	2.19e-01	0.095000	5.40e-01
Gastrulation	86	1.30e-01	0.094600	4.05e-01
Cohesin Loading onto Chromatin	10	6.05e-01	-0.094500	8.46e-01
SUMOylation of transcription cofactors	38	3.14e-01	-0.094400	6.47e-01
Diseases of mitotic cell cycle	35	3.37e-01	-0.093800	6.69e-01
Rab regulation of trafficking	118	7.99e-02	-0.093500	3.20e-01
Macroautophagy	113	8.66e-02	-0.093500	3.32e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	19	4.81e-01	-0.093400	7.83e-01
APC truncation mutants have impaired AXIN binding	14	5.47e-01	0.092900	8.15e-01
AXIN missense mutants destabilize the destruction complex	14	5.47e-01	0.092900	8.15e-01
Signaling by AMER1 mutants	14	5.47e-01	0.092900	8.15e-01
Signaling by APC mutants	14	5.47e-01	0.092900	8.15e-01
Signaling by AXIN mutants	14	5.47e-01	0.092900	8.15e-01
Truncations of AMER1 destabilize the destruction complex	14	5.47e-01	0.092900	8.15e-01
NCAM signaling for neurite out-growth	55	2.34e-01	0.092800	5.59e-01
MAPK family signaling cascades	269	9.12e-03	0.092700	1.09e-01
Signaling by NTRK2 (TRKB)	23	4.42e-01	0.092700	7.48e-01
RNA Polymerase I Transcription Termination	29	3.89e-01	0.092500	7.02e-01
Signaling by Rho GTPases	570	1.86e-04	0.092300	1.07e-02
Activation of SMO	16	5.24e-01	-0.092100	8.07e-01
Heme biosynthesis	13	5.67e-01	-0.091700	8.23e-01
NGF-stimulated transcription	32	3.70e-01	0.091600	6.90e-01
ATF4 activates genes in response to endoplasmic reticulum stress	24	4.37e-01	0.091600	7.44e-01
RAF activation	30	3.86e-01	0.091400	7.02e-01
RIP-mediated NFkB activation via ZBP1	12	5.85e-01	0.091100	8.32e-01
Activation of BH3-only proteins	25	4.31e-01	-0.091000	7.39e-01
TNFR2 non-canonical NF-kB pathway	79	1.63e-01	0.090900	4.62e-01
MyD88 cascade initiated on plasma membrane	81	1.59e-01	0.090600	4.54e-01
Toll Like Receptor 10 (TLR10) Cascade	81	1.59e-01	0.090600	4.54e-01
Toll Like Receptor 5 (TLR5) Cascade	81	1.59e-01	0.090600	4.54e-01
Signaling by CSF3 (G-CSF)	24	4.43e-01	0.090500	7.48e-01
PINK1-PRKN Mediated Mitophagy	15	5.44e-01	-0.090500	8.15e-01
SARS-CoV-2 modulates autophagy	10	6.21e-01	0.090300	8.58e-01
Transcriptional regulation of pluripotent stem cells	20	4.85e-01	-0.090100	7.87e-01
Generation of second messenger molecules	15	5.46e-01	-0.090000	8.15e-01
P2Y receptors	10	6.23e-01	-0.089700	8.58e-01
Nuclear Events (kinase and transcription factor activation)	53	2.60e-01	0.089600	5.83e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	26	4.31e-01	0.089300	7.39e-01
Growth hormone receptor signaling	17	5.24e-01	-0.089200	8.08e-01
Dual Incision in GG-NER	34	3.69e-01	-0.089000	6.90e-01
Pre-NOTCH Expression and Processing	53	2.63e-01	0.088900	5.87e-01
Receptor Mediated Mitophagy	10	6.26e-01	0.088900	8.58e-01
B-WICH complex positively regulates rRNA expression	36	3.56e-01	0.088900	6.79e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	18	5.14e-01	0.088800	8.05e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	18	5.14e-01	0.088800	8.05e-01
Lagging Strand Synthesis	17	5.27e-01	-0.088700	8.08e-01
APC-Cdc20 mediated degradation of Nek2A	21	4.82e-01	0.088600	7.85e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	585	2.82e-04	0.088600	1.51e-02
Signaling by EGFR in Cancer	18	5.16e-01	0.088500	8.05e-01
Regulation of NF-kappa B signaling	16	5.40e-01	0.088500	8.15e-01
HS-GAG biosynthesis	23	4.63e-01	-0.088500	7.65e-01
Synthesis of PC	25	4.44e-01	0.088500	7.49e-01
ABC transporters in lipid homeostasis	14	5.68e-01	0.088100	8.23e-01
Resolution of D-Loop Structures	29	4.12e-01	0.088000	7.23e-01
Signaling by FGFR2 in disease	35	3.69e-01	0.087800	6.90e-01
Extra-nuclear estrogen signaling	58	2.48e-01	0.087800	5.71e-01
Glutamate and glutamine metabolism	12	6.00e-01	-0.087600	8.42e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	71	2.03e-01	0.087500	5.20e-01
RAC2 GTPase cycle	79	1.81e-01	0.087200	4.91e-01
Phospholipase C-mediated cascade: FGFR1	10	6.34e-01	0.087000	8.59e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	3.88e-01	-0.086900	7.02e-01
Toll Like Receptor 9 (TLR9) Cascade	89	1.58e-01	0.086700	4.54e-01
TNFs bind their physiological receptors	16	5.49e-01	-0.086600	8.15e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	25	4.55e-01	0.086400	7.57e-01
HATs acetylate histones	81	1.79e-01	-0.086400	4.90e-01
Signaling by NOTCH1	68	2.19e-01	-0.086300	5.40e-01
Regulation of TP53 Activity through Acetylation	26	4.48e-01	-0.086000	7.51e-01
Neuronal System	302	1.06e-02	-0.085900	1.21e-01
Vitamin B5 (pantothenate) metabolism	14	5.81e-01	0.085300	8.29e-01
Defects in cobalamin (B12) metabolism	11	6.25e-01	-0.085200	8.58e-01
Cell Cycle Checkpoints	234	2.58e-02	0.084900	1.76e-01
Translation of Structural Proteins 9694635	51	2.95e-01	0.084800	6.19e-01
Negative regulation of FGFR4 signaling	22	4.93e-01	0.084600	7.92e-01
Toll-like Receptor Cascades	128	9.95e-02	0.084500	3.55e-01
Cleavage of the damaged purine	15	5.75e-01	0.083700	8.27e-01
Depurination	15	5.75e-01	0.083700	8.27e-01
Recognition and association of DNA glycosylase with site containing an affected purine	15	5.75e-01	0.083700	8.27e-01
Initiation of Nuclear Envelope (NE) Reformation	16	5.63e-01	0.083500	8.22e-01
DNA Replication Pre-Initiation	93	1.65e-01	0.083400	4.66e-01
Sema4D induced cell migration and growth-cone collapse	17	5.52e-01	0.083400	8.17e-01
Cytosolic tRNA aminoacylation	24	4.80e-01	0.083300	7.83e-01
N-Glycan antennae elongation	15	5.77e-01	-0.083200	8.29e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	5.78e-01	0.082900	8.29e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	6.35e-01	0.082800	8.59e-01
Signaling by ERBB2 TMD/JMD mutants	18	5.44e-01	-0.082700	8.15e-01
Transcriptional Regulation by MECP2	48	3.23e-01	0.082600	6.57e-01
G alpha (12/13) signalling events	60	2.69e-01	0.082500	5.92e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	3.39e-01	0.082500	6.70e-01
Regulation of TP53 Degradation	33	4.14e-01	-0.082200	7.26e-01
Nervous system development	492	1.97e-03	0.082100	4.69e-02
Signaling by Receptor Tyrosine Kinases	434	3.64e-03	0.081900	6.33e-02
Cell Cycle, Mitotic	456	3.09e-03	0.081400	5.64e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	4.93e-01	0.080900	7.92e-01
PTEN Regulation	123	1.23e-01	0.080700	3.90e-01
Calnexin/calreticulin cycle	24	4.95e-01	0.080500	7.92e-01
Regulation of TP53 Activity through Methylation	16	5.78e-01	0.080400	8.29e-01
ER to Golgi Anterograde Transport	130	1.14e-01	0.080300	3.80e-01
Diseases of carbohydrate metabolism	28	4.64e-01	0.080000	7.65e-01
Telomere C-strand synthesis initiation	13	6.18e-01	-0.079900	8.56e-01
Asparagine N-linked glycosylation	265	2.59e-02	0.079800	1.76e-01
Regulation of HSF1-mediated heat shock response	76	2.30e-01	-0.079700	5.59e-01
EGFR downregulation	24	5.00e-01	0.079700	7.94e-01
Intra-Golgi traffic	40	3.84e-01	-0.079600	7.02e-01
Regulation of IFNA/IFNB signaling	12	6.33e-01	0.079500	8.59e-01
Heme signaling	41	3.79e-01	-0.079400	6.98e-01
Transcriptional regulation by small RNAs	53	3.18e-01	-0.079300	6.54e-01
G2/M Checkpoints	122	1.31e-01	0.079200	4.07e-01
Signaling by the B Cell Receptor (BCR)	100	1.74e-01	0.078800	4.82e-01
Late SARS-CoV-2 Infection Events	58	3.00e-01	0.078800	6.25e-01
Cytosolic sensors of pathogen-associated DNA	48	3.46e-01	0.078700	6.76e-01
FRS-mediated FGFR2 signaling	18	5.65e-01	0.078300	8.22e-01
rRNA processing in the nucleus and cytosol	158	9.18e-02	0.077900	3.39e-01
Carnitine metabolism	13	6.27e-01	0.077900	8.58e-01
RAB geranylgeranylation	54	3.24e-01	-0.077700	6.57e-01
Cellular response to heat stress	93	1.99e-01	-0.077200	5.19e-01
G-protein beta:gamma signalling	18	5.71e-01	0.077100	8.26e-01
RHOC GTPase cycle	63	2.91e-01	0.076900	6.17e-01
Nuclear Envelope (NE) Reassembly	62	2.95e-01	0.076900	6.19e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	65	2.86e-01	-0.076600	6.12e-01
Metabolism of nucleotides	80	2.38e-01	0.076400	5.63e-01
RAB GEFs exchange GTP for GDP on RABs	87	2.20e-01	-0.076300	5.41e-01
Keratan sulfate/keratin metabolism	28	4.87e-01	-0.075900	7.89e-01
Effects of PIP2 hydrolysis	23	5.29e-01	0.075800	8.10e-01
Potential therapeutics for SARS	86	2.26e-01	-0.075600	5.52e-01
IGF1R signaling cascade	42	3.97e-01	0.075500	7.14e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	42	3.97e-01	0.075500	7.14e-01
p38MAPK events	11	6.65e-01	-0.075300	8.79e-01
Early SARS-CoV-2 Infection Events	27	5.01e-01	0.074900	7.94e-01
Cytokine Signaling in Immune system	514	4.00e-03	0.074700	6.64e-02
Cellular response to starvation	115	1.68e-01	0.074600	4.73e-01
Dual incision in TC-NER	57	3.32e-01	-0.074400	6.65e-01
MASTL Facilitates Mitotic Progression	10	6.85e-01	-0.074100	8.93e-01
tRNA modification in the nucleus and cytosol	36	4.43e-01	0.074000	7.48e-01
GPVI-mediated activation cascade	28	4.99e-01	0.073900	7.94e-01
Chondroitin sulfate biosynthesis	17	5.99e-01	-0.073600	8.42e-01
RHOG GTPase cycle	67	2.98e-01	0.073600	6.22e-01
Notch-HLH transcription pathway	26	5.16e-01	-0.073600	8.05e-01
Developmental Biology	790	5.29e-04	0.073400	2.31e-02
HS-GAG degradation	18	5.95e-01	0.072400	8.39e-01
Paracetamol ADME	17	6.06e-01	0.072300	8.46e-01
SARS-CoV-1-host interactions	68	3.05e-01	0.071900	6.33e-01
HIV Life Cycle	135	1.50e-01	-0.071800	4.43e-01
Mitochondrial translation initiation	81	2.65e-01	0.071700	5.88e-01
Nephrin family interactions	19	5.89e-01	0.071600	8.36e-01
Keratan sulfate biosynthesis	22	5.61e-01	-0.071600	8.22e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	6.81e-01	0.071600	8.90e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	6.22e-01	-0.071200	8.58e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	56	3.58e-01	-0.071100	6.79e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	18	6.04e-01	-0.070600	8.46e-01
Metabolism of non-coding RNA	50	3.89e-01	-0.070500	7.02e-01
snRNP Assembly	50	3.89e-01	-0.070500	7.02e-01
MAPK1/MAPK3 signaling	235	6.37e-02	0.070500	2.84e-01
Acyl chain remodelling of PS	14	6.49e-01	0.070300	8.66e-01
Major pathway of rRNA processing in the nucleolus and cytosol	149	1.42e-01	0.069900	4.31e-01
Phase I - Functionalization of compounds	64	3.35e-01	0.069700	6.68e-01
Influenza Infection	127	1.76e-01	0.069600	4.86e-01
rRNA processing	178	1.11e-01	0.069500	3.75e-01
Mitophagy	22	5.73e-01	-0.069400	8.27e-01
Mitochondrial translation termination	81	2.81e-01	0.069400	6.05e-01
Interleukin-20 family signaling	13	6.66e-01	0.069200	8.79e-01
EPH-ephrin mediated repulsion of cells	48	4.07e-01	-0.069200	7.21e-01
mRNA Capping	28	5.26e-01	0.069200	8.08e-01
Cellular responses to stimuli	643	3.04e-03	0.069100	5.62e-02
Cytosolic sulfonation of small molecules	14	6.54e-01	-0.069100	8.70e-01
C-type lectin receptors (CLRs)	98	2.39e-01	0.069000	5.63e-01
Depolymerization of the Nuclear Lamina	14	6.57e-01	0.068600	8.72e-01
SUMOylation	150	1.49e-01	-0.068500	4.41e-01
activated TAK1 mediates p38 MAPK activation	19	6.08e-01	0.067900	8.47e-01
SARS-CoV-2-host interactions	151	1.51e-01	-0.067900	4.43e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	51	4.02e-01	-0.067800	7.20e-01
Anchoring of the basal body to the plasma membrane	91	2.66e-01	0.067500	5.88e-01
Acyl chain remodelling of PG	12	6.86e-01	0.067500	8.93e-01
DNA methylation	10	7.12e-01	0.067500	9.02e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	6.41e-01	-0.067400	8.60e-01
IRS-related events triggered by IGF1R	41	4.55e-01	0.067400	7.57e-01
Late Phase of HIV Life Cycle	123	2.00e-01	-0.067000	5.19e-01
NF-kB is activated and signals survival	10	7.15e-01	0.066600	9.02e-01
Miscellaneous transport and binding events	20	6.07e-01	0.066500	8.46e-01
G1/S Transition	117	2.15e-01	0.066400	5.36e-01
Regulation of lipid metabolism by PPARalpha	100	2.53e-01	0.066300	5.73e-01
Costimulation by the CD28 family	46	4.38e-01	0.066200	7.44e-01
mRNA decay by 3’ to 5’ exoribonuclease	15	6.58e-01	0.066100	8.73e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	25	5.68e-01	-0.066100	8.23e-01
Activation of the TFAP2 (AP-2) family of transcription factors	10	7.18e-01	0.066100	9.02e-01
RHO GTPase cycle	396	2.51e-02	0.065900	1.73e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	6.39e-01	-0.065700	8.60e-01
Signaling by NOTCH	166	1.45e-01	0.065700	4.35e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	28	5.48e-01	0.065600	8.15e-01
Early Phase of HIV Life Cycle	13	6.83e-01	-0.065400	8.92e-01
Sphingolipid metabolism	79	3.16e-01	-0.065300	6.50e-01
RMTs methylate histone arginines	32	5.23e-01	0.065200	8.07e-01
Removal of the Flap Intermediate	11	7.08e-01	-0.065100	9.02e-01
Signaling by NODAL	13	6.84e-01	-0.065100	8.93e-01
Influenza Viral RNA Transcription and Replication	111	2.37e-01	0.065000	5.63e-01
Cell Cycle	573	8.40e-03	0.065000	1.01e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	5.45e-01	0.064900	8.15e-01
COPI-independent Golgi-to-ER retrograde traffic	44	4.57e-01	0.064800	7.58e-01
RAF/MAP kinase cascade	229	9.21e-02	0.064800	3.39e-01
Class B/2 (Secretin family receptors)	55	4.06e-01	-0.064800	7.21e-01
DNA strand elongation	29	5.47e-01	-0.064600	8.15e-01
Degradation of beta-catenin by the destruction complex	78	3.27e-01	0.064300	6.59e-01
Mitotic G1 phase and G1/S transition	133	2.01e-01	0.064300	5.20e-01
CS/DS degradation	12	7.00e-01	-0.064300	9.01e-01
Killing mechanisms	10	7.25e-01	-0.064200	9.02e-01
WNT5:FZD7-mediated leishmania damping	10	7.25e-01	-0.064200	9.02e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	35	5.15e-01	0.063700	8.05e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	6.91e-01	0.063700	8.93e-01
Intrinsic Pathway of Fibrin Clot Formation	12	7.04e-01	-0.063300	9.02e-01
Factors involved in megakaryocyte development and platelet production	119	2.34e-01	0.063300	5.59e-01
Signaling by PDGFR in disease	16	6.62e-01	0.063100	8.76e-01
Acyl chain remodelling of PC	19	6.36e-01	0.062800	8.59e-01
Phase II - Conjugation of compounds	59	4.06e-01	0.062600	7.21e-01
FRS-mediated FGFR3 signaling	15	6.76e-01	0.062400	8.85e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	20	6.29e-01	-0.062400	8.59e-01
GPCR ligand binding	226	1.08e-01	0.062300	3.68e-01
PPARA activates gene expression	98	2.88e-01	0.062200	6.14e-01
Processing of Intronless Pre-mRNAs	14	6.87e-01	-0.062100	8.93e-01
RHO GTPases Activate NADPH Oxidases	20	6.31e-01	0.062100	8.59e-01
Negative regulation of the PI3K/AKT network	89	3.13e-01	0.062000	6.45e-01
G1/S-Specific Transcription	28	5.71e-01	-0.062000	8.26e-01
Packaging Of Telomere Ends	12	7.10e-01	0.061900	9.02e-01
Negative regulators of DDX58/IFIH1 signaling	23	6.08e-01	-0.061800	8.47e-01
Nonhomologous End-Joining (NHEJ)	31	5.52e-01	0.061800	8.17e-01
Methylation	11	7.23e-01	0.061800	9.02e-01
Surfactant metabolism	21	6.25e-01	-0.061700	8.58e-01
Common Pathway of Fibrin Clot Formation	14	6.90e-01	-0.061500	8.93e-01
G0 and Early G1	27	5.80e-01	-0.061500	8.29e-01
Transport of Mature Transcript to Cytoplasm	73	3.65e-01	-0.061400	6.86e-01
Protein localization	142	2.08e-01	-0.061400	5.25e-01
DAP12 interactions	26	5.89e-01	0.061200	8.36e-01
Switching of origins to a post-replicative state	81	3.43e-01	0.061000	6.75e-01
Cytochrome c-mediated apoptotic response	10	7.39e-01	0.061000	9.10e-01
SUMO E3 ligases SUMOylate target proteins	144	2.09e-01	-0.060800	5.26e-01
Signaling by SCF-KIT	38	5.18e-01	0.060600	8.05e-01
Mitochondrial translation elongation	81	3.48e-01	0.060300	6.76e-01
Apoptotic factor-mediated response	15	6.86e-01	0.060200	8.93e-01
Endogenous sterols	21	6.33e-01	0.060200	8.59e-01
Clathrin-mediated endocytosis	121	2.55e-01	0.060000	5.76e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	6.88e-01	0.059800	8.93e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	17	6.70e-01	0.059800	8.82e-01
Cargo trafficking to the periciliary membrane	44	4.94e-01	-0.059600	7.92e-01
Mismatch Repair	12	7.21e-01	-0.059600	9.02e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	17	6.73e-01	-0.059200	8.85e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	22	6.31e-01	0.059200	8.59e-01
Regulation of IFNG signaling	12	7.23e-01	0.059200	9.02e-01
SHC-mediated cascade:FGFR4	13	7.12e-01	-0.059100	9.02e-01
FLT3 signaling in disease	23	6.24e-01	0.059000	8.58e-01
SHC-mediated cascade:FGFR1	14	7.03e-01	0.058800	9.02e-01
TCF dependent signaling in response to WNT	159	2.05e-01	0.058300	5.21e-01
Activation of AMPK downstream of NMDARs	20	6.52e-01	0.058200	8.69e-01
Anti-inflammatory response favouring Leishmania parasite infection	64	4.22e-01	0.058100	7.33e-01
Leishmania parasite growth and survival	64	4.22e-01	0.058100	7.33e-01
Netrin-1 signaling	42	5.15e-01	0.058100	8.05e-01
G beta:gamma signalling through PI3Kgamma	13	7.18e-01	-0.057900	9.02e-01
COPI-mediated anterograde transport	85	3.59e-01	0.057600	6.79e-01
Detoxification of Reactive Oxygen Species	29	5.92e-01	0.057500	8.36e-01
Regulation of CDH11 mRNA translation by microRNAs	10	7.53e-01	0.057500	9.11e-01
Telomere C-strand (Lagging Strand) Synthesis	30	5.89e-01	-0.057100	8.36e-01
Biological oxidations	127	2.70e-01	0.056800	5.92e-01
Interleukin-2 family signaling	30	5.91e-01	0.056700	8.36e-01
Signaling by Insulin receptor	63	4.37e-01	-0.056700	7.44e-01
NoRC negatively regulates rRNA expression	51	4.84e-01	0.056600	7.86e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	30	5.92e-01	-0.056600	8.36e-01
Membrane binding and targetting of GAG proteins	11	7.45e-01	0.056600	9.11e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	11	7.45e-01	0.056600	9.11e-01
Disease	1367	6.01e-04	0.056500	2.48e-02
PKMTs methylate histone lysines	36	5.59e-01	0.056400	8.20e-01
Removal of the Flap Intermediate from the C-strand	14	7.17e-01	-0.056000	9.02e-01
RNA Polymerase III Transcription Initiation	33	5.78e-01	-0.055900	8.29e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	24	6.39e-01	-0.055400	8.60e-01
RNA Polymerase II Pre-transcription Events	75	4.09e-01	-0.055200	7.21e-01
Cellular responses to stress	630	1.94e-02	0.055100	1.57e-01
Nucleotide catabolism	27	6.22e-01	-0.054800	8.58e-01
Diseases of signal transduction by growth factor receptors and second messengers	376	6.98e-02	0.054800	2.94e-01
E3 ubiquitin ligases ubiquitinate target proteins	42	5.40e-01	-0.054700	8.15e-01
Regulation of TP53 Expression and Degradation	34	5.83e-01	-0.054500	8.30e-01
Deposition of new CENPA-containing nucleosomes at the centromere	26	6.32e-01	0.054400	8.59e-01
Nucleosome assembly	26	6.32e-01	0.054400	8.59e-01
Presynaptic function of Kainate receptors	11	7.55e-01	-0.054300	9.11e-01
Glucagon signaling in metabolic regulation	20	6.74e-01	-0.054300	8.85e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	11	7.55e-01	0.054300	9.11e-01
Synthesis of PIPs at the Golgi membrane	14	7.25e-01	-0.054200	9.02e-01
Resolution of Abasic Sites (AP sites)	31	6.02e-01	-0.054200	8.45e-01
Infectious disease	737	1.33e-02	0.054200	1.34e-01
RHOBTB GTPase Cycle	33	5.91e-01	0.054000	8.36e-01
Class I MHC mediated antigen processing & presentation	321	9.91e-02	0.053800	3.55e-01
Transcriptional regulation by RUNX1	155	2.49e-01	0.053700	5.71e-01
Synthesis of PIPs at the plasma membrane	46	5.29e-01	0.053600	8.10e-01
RND3 GTPase cycle	39	5.64e-01	0.053400	8.22e-01
ISG15 antiviral mechanism	64	4.63e-01	-0.053100	7.65e-01
Mitochondrial biogenesis	83	4.06e-01	-0.052800	7.21e-01
Triglyceride catabolism	16	7.16e-01	-0.052500	9.02e-01
Interferon Signaling	137	2.91e-01	0.052400	6.17e-01
Constitutive Signaling by Overexpressed ERBB2	10	7.74e-01	-0.052400	9.19e-01
PRC2 methylates histones and DNA	19	6.94e-01	0.052200	8.96e-01
Formation of annular gap junctions	11	7.65e-01	-0.052100	9.15e-01
Nuclear signaling by ERBB4	26	6.46e-01	0.052000	8.64e-01
FGFR2 ligand binding and activation	14	7.36e-01	0.052000	9.09e-01
Signalling to RAS	17	7.11e-01	-0.052000	9.02e-01
trans-Golgi Network Vesicle Budding	64	4.74e-01	0.051900	7.75e-01
S Phase	145	2.82e-01	0.051800	6.06e-01
The role of Nef in HIV-1 replication and disease pathogenesis	19	6.98e-01	-0.051500	8.99e-01
EPHB-mediated forward signaling	40	5.74e-01	0.051400	8.27e-01
Golgi Associated Vesicle Biogenesis	50	5.31e-01	0.051300	8.11e-01
Signaling by Activin	13	7.49e-01	-0.051200	9.11e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	6.47e-01	0.051000	8.64e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	6.47e-01	0.051000	8.64e-01
Glyoxylate metabolism and glycine degradation	28	6.41e-01	0.051000	8.60e-01
Transport to the Golgi and subsequent modification	158	2.71e-01	0.050800	5.94e-01
Formation of RNA Pol II elongation complex	56	5.13e-01	0.050600	8.05e-01
RNA Polymerase II Transcription Elongation	56	5.13e-01	0.050600	8.05e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	4.98e-01	0.049900	7.94e-01
Sensory Perception	151	2.92e-01	0.049800	6.17e-01
STING mediated induction of host immune responses	12	7.67e-01	0.049400	9.16e-01
Meiosis	59	5.13e-01	-0.049300	8.05e-01
Inactivation of CSF3 (G-CSF) signaling	19	7.10e-01	0.049200	9.02e-01
Mitochondrial Fatty Acid Beta-Oxidation	31	6.36e-01	-0.049200	8.59e-01
CTLA4 inhibitory signaling	19	7.11e-01	0.049200	9.02e-01
DNA Damage/Telomere Stress Induced Senescence	36	6.10e-01	0.049200	8.48e-01
Intraflagellar transport	46	5.66e-01	-0.048900	8.22e-01
PLC beta mediated events	39	5.98e-01	-0.048800	8.42e-01
Signal Transduction	1971	5.46e-04	0.048600	2.32e-02
Ephrin signaling	18	7.21e-01	0.048500	9.02e-01
Signaling by Nuclear Receptors	197	2.43e-01	0.048400	5.70e-01
WNT5A-dependent internalization of FZD4	15	7.46e-01	-0.048400	9.11e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	4.44e-01	0.048300	7.49e-01
Transport of vitamins, nucleosides, and related molecules	28	6.60e-01	-0.048000	8.75e-01
Synthesis of DNA	105	3.97e-01	0.047900	7.14e-01
tRNA processing in the mitochondrion	17	7.33e-01	0.047800	9.06e-01
Pre-NOTCH Processing in Golgi	15	7.49e-01	0.047800	9.11e-01
Mitochondrial translation	87	4.42e-01	0.047700	7.48e-01
Senescence-Associated Secretory Phenotype (SASP)	49	5.65e-01	0.047500	8.22e-01
tRNA processing	112	3.86e-01	-0.047500	7.02e-01
Hedgehog ‘on’ state	77	4.72e-01	0.047500	7.73e-01
Metabolism of lipids	592	5.14e-02	0.047300	2.51e-01
BBSome-mediated cargo-targeting to cilium	20	7.16e-01	-0.047000	9.02e-01
Postmitotic nuclear pore complex (NPC) reformation	26	6.78e-01	-0.047000	8.88e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	14	7.61e-01	-0.047000	9.12e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	15	7.54e-01	-0.046800	9.11e-01
Interleukin-12 signaling	36	6.28e-01	0.046700	8.58e-01
DNA Damage Recognition in GG-NER	32	6.50e-01	0.046300	8.67e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	7.73e-01	0.046300	9.19e-01
Other interleukin signaling	18	7.37e-01	-0.045700	9.09e-01
Metabolism of amino acids and derivatives	296	1.80e-01	0.045500	4.90e-01
Potassium Channels	68	5.18e-01	0.045400	8.05e-01
RHOBTB1 GTPase cycle	22	7.13e-01	0.045300	9.02e-01
ERK/MAPK targets	21	7.22e-01	0.044900	9.02e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	11	7.97e-01	0.044700	9.29e-01
Circadian Clock	60	5.50e-01	-0.044600	8.16e-01
Platelet homeostasis	59	5.54e-01	-0.044500	8.19e-01
SARS-CoV-1 Infection	106	4.31e-01	0.044400	7.39e-01
Transcriptional regulation of white adipocyte differentiation	76	5.10e-01	0.043800	8.05e-01
LDL clearance	16	7.63e-01	0.043600	9.14e-01
G alpha (z) signalling events	33	6.68e-01	0.043100	8.81e-01
Epigenetic regulation of gene expression	124	4.08e-01	-0.043100	7.21e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	22	7.27e-01	0.043000	9.02e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	22	7.27e-01	0.043000	9.02e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	22	7.27e-01	0.043000	9.02e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	22	7.27e-01	0.043000	9.02e-01
Impaired BRCA2 binding to PALB2	22	7.27e-01	0.043000	9.02e-01
DNA Replication	117	4.23e-01	0.042900	7.33e-01
Cytochrome P450 - arranged by substrate type	37	6.53e-01	0.042700	8.70e-01
Formation of Fibrin Clot (Clotting Cascade)	22	7.31e-01	0.042300	9.05e-01
PI Metabolism	71	5.39e-01	0.042200	8.15e-01
Stimuli-sensing channels	72	5.38e-01	-0.042100	8.15e-01
Metabolism of RNA	632	7.42e-02	0.042000	3.07e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	79	5.20e-01	-0.041900	8.05e-01
NRAGE signals death through JNK	51	6.05e-01	0.041900	8.46e-01
PIP3 activates AKT signaling	228	2.79e-01	0.041800	6.02e-01
Lysosome Vesicle Biogenesis	31	6.88e-01	0.041700	8.93e-01
Heparan sulfate/heparin (HS-GAG) metabolism	45	6.32e-01	-0.041200	8.59e-01
Interleukin-12 family signaling	44	6.38e-01	0.041000	8.60e-01
Transcriptional activation of mitochondrial biogenesis	49	6.20e-01	-0.041000	8.58e-01
Voltage gated Potassium channels	32	6.89e-01	-0.040900	8.93e-01
Inhibition of DNA recombination at telomere	26	7.19e-01	0.040800	9.02e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	17	7.72e-01	-0.040700	9.19e-01
HCMV Late Events	59	5.92e-01	-0.040400	8.36e-01
ESR-mediated signaling	140	4.12e-01	0.040300	7.23e-01
Chromatin modifying enzymes	187	3.47e-01	-0.040000	6.76e-01
Chromatin organization	187	3.47e-01	-0.040000	6.76e-01
Signaling by Hippo	18	7.70e-01	0.039800	9.19e-01
Cell death signalling via NRAGE, NRIF and NADE	65	5.81e-01	0.039600	8.29e-01
Signaling by Retinoic Acid	36	6.81e-01	-0.039600	8.90e-01
Metabolism of proteins	1537	1.15e-02	0.039500	1.22e-01
p75 NTR receptor-mediated signalling	83	5.36e-01	0.039300	8.15e-01
Transcriptional Regulation by TP53	318	2.30e-01	-0.039300	5.59e-01
Metabolic disorders of biological oxidation enzymes	26	7.29e-01	0.039300	9.04e-01
ZBP1(DAI) mediated induction of type I IFNs	15	7.93e-01	0.039100	9.27e-01
Antigen processing: Ubiquitination & Proteasome degradation	263	2.81e-01	0.038800	6.05e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	11	8.25e-01	-0.038600	9.40e-01
PI3K/AKT Signaling in Cancer	84	5.45e-01	-0.038300	8.15e-01
Pentose phosphate pathway	12	8.19e-01	0.038200	9.39e-01
PI3K Cascade	34	7.01e-01	0.038100	9.01e-01
Downregulation of TGF-beta receptor signaling	22	7.58e-01	0.038000	9.12e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	8.13e-01	0.037900	9.37e-01
MAPK targets/ Nuclear events mediated by MAP kinases	30	7.21e-01	0.037700	9.02e-01
Activation of G protein gated Potassium channels	18	7.84e-01	0.037300	9.24e-01
G protein gated Potassium channels	18	7.84e-01	0.037300	9.24e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	7.84e-01	0.037300	9.24e-01
Signaling by ERBB4	47	6.61e-01	0.037000	8.76e-01
Negative epigenetic regulation of rRNA expression	54	6.41e-01	0.036700	8.60e-01
Glutathione conjugation	26	7.49e-01	0.036200	9.11e-01
Processive synthesis on the lagging strand	12	8.28e-01	-0.036200	9.40e-01
Formation of the beta-catenin:TCF transactivating complex	36	7.08e-01	0.036100	9.02e-01
ERKs are inactivated	12	8.29e-01	0.036000	9.40e-01
L1CAM interactions	104	5.33e-01	0.035500	8.13e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	68	6.15e-01	-0.035300	8.54e-01
Selective autophagy	66	6.21e-01	-0.035300	8.58e-01
Activation of GABAB receptors	29	7.43e-01	0.035200	9.11e-01
GABA B receptor activation	29	7.43e-01	0.035200	9.11e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	31	7.36e-01	-0.035100	9.09e-01
FGFR2 alternative splicing	23	7.73e-01	0.034700	9.19e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	183	4.23e-01	0.034400	7.33e-01
GABA receptor activation	39	7.12e-01	0.034100	9.02e-01
Attenuation phase	22	7.82e-01	-0.034100	9.24e-01
TP53 Regulates Transcription of Cell Death Genes	32	7.39e-01	-0.034100	9.10e-01
Fanconi Anemia Pathway	30	7.47e-01	0.034000	9.11e-01
Prolonged ERK activation events	14	8.26e-01	-0.034000	9.40e-01
SHC1 events in ERBB2 signaling	18	8.03e-01	0.033900	9.34e-01
Cyclin A/B1/B2 associated events during G2/M transition	23	7.79e-01	0.033900	9.22e-01
mRNA 3’-end processing	45	6.96e-01	0.033700	8.98e-01
Regulation of TNFR1 signaling	42	7.06e-01	0.033600	9.02e-01
Extension of Telomeres	47	6.91e-01	-0.033500	8.93e-01
Cellular Senescence	127	5.19e-01	0.033200	8.05e-01
Vesicle-mediated transport	588	1.76e-01	0.032900	4.86e-01
Regulation of TP53 Activity through Phosphorylation	83	6.07e-01	-0.032700	8.47e-01
G-protein mediated events	44	7.08e-01	-0.032600	9.02e-01
Signaling by ERBB2 ECD mutants	15	8.28e-01	-0.032400	9.40e-01
Glucagon-type ligand receptors	14	8.35e-01	-0.032100	9.42e-01
Peptide hormone metabolism	59	6.71e-01	-0.032000	8.84e-01
Integration of energy metabolism	77	6.28e-01	-0.032000	8.58e-01
Transport of small molecules	531	2.12e-01	-0.031900	5.31e-01
RNA Polymerase II Transcription Termination	53	6.89e-01	0.031800	8.93e-01
Gene expression (Transcription)	1063	8.49e-02	-0.031800	3.28e-01
Translesion synthesis by POLI	15	8.31e-01	0.031800	9.40e-01
Processing of Capped Intronless Pre-mRNA	22	7.96e-01	-0.031800	9.29e-01
Adenylate cyclase inhibitory pathway	11	8.55e-01	0.031700	9.54e-01
Synthesis of IP3 and IP4 in the cytosol	23	7.93e-01	0.031700	9.27e-01
Translesion synthesis by REV1	14	8.38e-01	0.031600	9.44e-01
Pyruvate metabolism	28	7.73e-01	0.031500	9.19e-01
mRNA Splicing - Minor Pathway	43	7.22e-01	0.031400	9.02e-01
Intracellular signaling by second messengers	260	3.87e-01	0.031300	7.02e-01
VxPx cargo-targeting to cilium	18	8.18e-01	-0.031300	9.39e-01
Meiotic synapsis	35	7.50e-01	-0.031100	9.11e-01
DNA Repair	257	3.92e-01	-0.031100	7.07e-01
Regulation of TP53 Activity	144	5.20e-01	-0.031100	8.05e-01
FCGR3A-mediated IL10 synthesis	38	7.41e-01	0.031000	9.11e-01
FGFR2 mutant receptor activation	26	7.86e-01	0.030800	9.24e-01
Gap junction trafficking and regulation	33	7.59e-01	-0.030800	9.12e-01
RAF-independent MAPK1/3 activation	22	8.04e-01	0.030500	9.34e-01
GPCR downstream signalling	370	3.20e-01	0.030300	6.54e-01
Unwinding of DNA	12	8.56e-01	-0.030200	9.54e-01
Azathioprine ADME	18	8.25e-01	0.030100	9.40e-01
A tetrasaccharide linker sequence is required for GAG synthesis	22	8.08e-01	-0.029900	9.34e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	15	8.41e-01	0.029900	9.46e-01
Beta-catenin phosphorylation cascade	17	8.34e-01	0.029400	9.42e-01
HCMV Infection	96	6.22e-01	0.029100	8.58e-01
Signaling by WNT	235	4.45e-01	0.029000	7.49e-01
SHC1 events in ERBB4 signaling	10	8.74e-01	-0.029000	9.60e-01
Defects in vitamin and cofactor metabolism	19	8.27e-01	0.029000	9.40e-01
Metalloprotease DUBs	17	8.37e-01	0.028800	9.44e-01
Insulin receptor signalling cascade	42	7.47e-01	0.028800	9.11e-01
DNA Double Strand Break Response	38	7.60e-01	0.028600	9.12e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	38	7.60e-01	0.028600	9.12e-01
Defective pyroptosis	19	8.29e-01	-0.028600	9.40e-01
Signaling by FLT3 fusion proteins	17	8.39e-01	-0.028400	9.45e-01
Signaling by GPCR	419	3.23e-01	0.028300	6.57e-01
ADORA2B mediated anti-inflammatory cytokines production	29	7.92e-01	-0.028300	9.27e-01
mRNA Splicing - Major Pathway	179	5.15e-01	0.028300	8.05e-01
Viral Infection Pathways	581	2.49e-01	0.028200	5.71e-01
MAP kinase activation	57	7.13e-01	0.028200	9.02e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	12	8.66e-01	0.028200	9.59e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	41	7.56e-01	0.028100	9.11e-01
HIV Transcription Elongation	41	7.56e-01	0.028100	9.11e-01
Tat-mediated elongation of the HIV-1 transcript	41	7.56e-01	0.028100	9.11e-01
DAG and IP3 signaling	33	7.84e-01	-0.027600	9.24e-01
FRS-mediated FGFR4 signaling	15	8.54e-01	0.027500	9.54e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	11	8.76e-01	-0.027200	9.60e-01
Glycerophospholipid biosynthesis	102	6.41e-01	-0.026700	8.60e-01
Recycling pathway of L1	39	7.73e-01	0.026700	9.19e-01
Opioid Signalling	69	7.05e-01	-0.026300	9.02e-01
SARS-CoV-1 activates/modulates innate immune responses	26	8.19e-01	0.026000	9.39e-01
RND1 GTPase cycle	39	7.79e-01	0.026000	9.22e-01
G alpha (s) signalling events	89	6.74e-01	-0.025800	8.85e-01
Diseases of DNA repair	47	7.62e-01	-0.025600	9.13e-01
GPER1 signaling	31	8.06e-01	0.025500	9.34e-01
Signalling to ERKs	30	8.09e-01	0.025500	9.34e-01
IRS-mediated signalling	37	7.89e-01	0.025400	9.27e-01
MECP2 regulates neuronal receptors and channels	16	8.61e-01	0.025300	9.56e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	52	7.52e-01	-0.025300	9.11e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	52	7.52e-01	-0.025300	9.11e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	52	7.52e-01	-0.025300	9.11e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	52	7.52e-01	-0.025300	9.11e-01
Signaling by NOTCH1 in Cancer	52	7.52e-01	-0.025300	9.11e-01
Bile acid and bile salt metabolism	28	8.17e-01	-0.025300	9.39e-01
Death Receptor Signaling	134	6.15e-01	0.025200	8.54e-01
Processing of Capped Intron-Containing Pre-mRNA	247	4.97e-01	-0.025200	7.94e-01
RHOH GTPase cycle	27	8.21e-01	0.025200	9.40e-01
Telomere Extension By Telomerase	23	8.35e-01	-0.025100	9.42e-01
Disorders of transmembrane transporters	144	6.05e-01	-0.025000	8.46e-01
TNF signaling	51	7.58e-01	-0.025000	9.12e-01
tRNA Aminoacylation	40	7.85e-01	0.024900	9.24e-01
Reproduction	78	7.04e-01	0.024900	9.02e-01
Oxidative Stress Induced Senescence	65	7.30e-01	0.024800	9.04e-01
Organelle biogenesis and maintenance	262	4.92e-01	-0.024800	7.92e-01
G alpha (q) signalling events	120	6.40e-01	0.024800	8.60e-01
NOD1/2 Signaling Pathway	28	8.23e-01	-0.024500	9.40e-01
Aggrephagy	33	8.08e-01	0.024500	9.34e-01
Synthesis of PE	10	8.96e-01	0.023900	9.67e-01
Neddylation	205	5.59e-01	0.023700	8.20e-01
Metabolism	1668	1.16e-01	0.023700	3.83e-01
Regulation of PTEN gene transcription	50	7.72e-01	-0.023700	9.19e-01
Ovarian tumor domain proteases	28	8.30e-01	0.023400	9.40e-01
RNA Polymerase III Chain Elongation	15	8.76e-01	0.023300	9.60e-01
Signaling by Non-Receptor Tyrosine Kinases	43	7.93e-01	-0.023200	9.27e-01
Signaling by PTK6	43	7.93e-01	-0.023200	9.27e-01
Phospholipase C-mediated cascade; FGFR2	12	8.90e-01	0.023000	9.66e-01
Formation of TC-NER Pre-Incision Complex	49	7.81e-01	-0.022900	9.24e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	13	8.87e-01	-0.022800	9.66e-01
alpha-linolenic acid (ALA) metabolism	13	8.87e-01	-0.022800	9.66e-01
RUNX3 regulates NOTCH signaling	13	8.87e-01	0.022700	9.66e-01
Chondroitin sulfate/dermatan sulfate metabolism	43	7.98e-01	0.022600	9.29e-01
Intrinsic Pathway for Apoptosis	44	7.96e-01	-0.022600	9.29e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	8.25e-01	0.022600	9.40e-01
Establishment of Sister Chromatid Cohesion	11	8.98e-01	-0.022400	9.67e-01
TRAF6 mediated IRF7 activation	10	9.03e-01	0.022300	9.71e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	22	8.57e-01	-0.022300	9.54e-01
Deubiquitination	214	5.79e-01	0.022100	8.29e-01
HSF1 activation	25	8.49e-01	0.022000	9.53e-01
Amino acid transport across the plasma membrane	24	8.53e-01	0.021900	9.54e-01
Ub-specific processing proteases	152	6.44e-01	0.021800	8.63e-01
Positive epigenetic regulation of rRNA expression	49	7.94e-01	0.021600	9.27e-01
RORA activates gene expression	18	8.74e-01	0.021600	9.60e-01
Inositol phosphate metabolism	38	8.20e-01	-0.021400	9.40e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	26	8.51e-01	-0.021300	9.54e-01
Assembly and cell surface presentation of NMDA receptors	34	8.30e-01	-0.021200	9.40e-01
Formation of HIV elongation complex in the absence of HIV Tat	43	8.12e-01	0.021000	9.36e-01
Activation of BAD and translocation to mitochondria	13	8.96e-01	-0.020900	9.67e-01
mRNA Splicing	185	6.26e-01	0.020800	8.58e-01
Regulation of signaling by CBL	19	8.77e-01	-0.020500	9.60e-01
Base-Excision Repair, AP Site Formation	21	8.71e-01	-0.020400	9.60e-01
Membrane Trafficking	547	4.25e-01	0.020100	7.35e-01
Signaling by ERBB2 in Cancer	22	8.71e-01	0.020000	9.60e-01
Mitochondrial tRNA aminoacylation	19	8.80e-01	0.020000	9.61e-01
MicroRNA (miRNA) biogenesis	24	8.67e-01	0.019800	9.59e-01
Nucleotide Excision Repair	95	7.39e-01	-0.019800	9.10e-01
Metabolism of vitamins and cofactors	154	6.75e-01	0.019600	8.85e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	25	8.66e-01	-0.019500	9.59e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	22	8.74e-01	0.019500	9.60e-01
PI3K events in ERBB2 signaling	13	9.04e-01	0.019300	9.71e-01
RNA Polymerase I Promoter Clearance	53	8.09e-01	0.019200	9.34e-01
RNA Polymerase I Transcription	53	8.09e-01	0.019200	9.34e-01
Activated NOTCH1 Transmits Signal to the Nucleus	29	8.60e-01	0.018900	9.56e-01
Formation of Incision Complex in GG-NER	38	8.41e-01	0.018800	9.46e-01
SHC-mediated cascade:FGFR3	13	9.07e-01	-0.018800	9.73e-01
EPH-Ephrin signaling	85	7.66e-01	0.018700	9.16e-01
HDR through MMEJ (alt-NHEJ)	12	9.11e-01	0.018600	9.74e-01
SARS-CoV Infections	328	5.64e-01	-0.018600	8.22e-01
TP53 Regulates Transcription of DNA Repair Genes	59	8.05e-01	-0.018600	9.34e-01
Formation of the Early Elongation Complex	32	8.57e-01	0.018400	9.54e-01
Formation of the HIV-1 Early Elongation Complex	32	8.57e-01	0.018400	9.54e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	13	9.12e-01	-0.017800	9.74e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	35	8.56e-01	0.017800	9.54e-01
rRNA modification in the nucleus and cytosol	52	8.31e-01	-0.017200	9.40e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	29	8.74e-01	0.017000	9.60e-01
HSF1-dependent transactivation	31	8.72e-01	-0.016700	9.60e-01
Defective B3GAT3 causes JDSSDHD	16	9.08e-01	-0.016700	9.74e-01
Post-translational protein modification	1126	3.57e-01	0.016600	6.79e-01
Nucleotide-like (purinergic) receptors	14	9.15e-01	-0.016500	9.74e-01
Glycolysis	70	8.13e-01	0.016300	9.37e-01
Negative regulation of MAPK pathway	37	8.64e-01	0.016300	9.58e-01
Metabolism of carbohydrates	250	6.60e-01	0.016200	8.75e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	19	9.03e-01	0.016100	9.71e-01
Receptor-type tyrosine-protein phosphatases	16	9.12e-01	0.016000	9.74e-01
Regulation of beta-cell development	26	8.88e-01	-0.016000	9.66e-01
Nicotinate metabolism	26	8.89e-01	-0.015800	9.66e-01
Deadenylation-dependent mRNA decay	50	8.50e-01	-0.015500	9.53e-01
Thromboxane signalling through TP receptor	13	9.23e-01	0.015400	9.78e-01
Activation of the AP-1 family of transcription factors	10	9.33e-01	0.015400	9.82e-01
O-linked glycosylation	76	8.18e-01	-0.015300	9.39e-01
Activated point mutants of FGFR2	11	9.30e-01	-0.015300	9.81e-01
G beta:gamma signalling through PLC beta	10	9.36e-01	0.014800	9.82e-01
TP53 Regulates Metabolic Genes	74	8.26e-01	0.014800	9.40e-01
Deactivation of the beta-catenin transactivating complex	35	8.80e-01	0.014700	9.61e-01
Regulation of insulin secretion	53	8.55e-01	-0.014600	9.54e-01
Cyclin D associated events in G1	39	8.76e-01	0.014500	9.60e-01
G1 Phase	39	8.76e-01	0.014500	9.60e-01
Pausing and recovery of Tat-mediated HIV elongation	30	8.92e-01	0.014400	9.66e-01
Tat-mediated HIV elongation arrest and recovery	30	8.92e-01	0.014400	9.66e-01
SHC-mediated cascade:FGFR2	16	9.21e-01	0.014300	9.76e-01
Metal ion SLC transporters	20	9.14e-01	0.013900	9.74e-01
TNFR1-induced proapoptotic signaling	22	9.10e-01	-0.013900	9.74e-01
SARS-CoV-2 Infection	228	7.24e-01	-0.013600	9.02e-01
Chromosome Maintenance	87	8.28e-01	0.013500	9.40e-01
Host Interactions of HIV factors	111	8.06e-01	0.013500	9.34e-01
NRIF signals cell death from the nucleus	14	9.31e-01	-0.013400	9.81e-01
Translesion synthesis by POLK	15	9.29e-01	-0.013300	9.81e-01
HDACs deacetylate histones	35	8.94e-01	0.013100	9.67e-01
Platelet calcium homeostasis	22	9.18e-01	0.012700	9.76e-01
Peroxisomal protein import	56	8.70e-01	-0.012700	9.60e-01
Sensory processing of sound by outer hair cells of the cochlea	37	8.94e-01	0.012600	9.67e-01
Mitochondrial iron-sulfur cluster biogenesis	11	9.44e-01	0.012200	9.83e-01
SUMOylation of intracellular receptors	23	9.20e-01	-0.012100	9.76e-01
Nuclear events stimulated by ALK signaling in cancer	15	9.36e-01	0.012000	9.82e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	9.36e-01	-0.012000	9.82e-01
Translation of Structural Proteins 9683701	25	9.19e-01	0.011800	9.76e-01
Muscle contraction	149	8.05e-01	0.011700	9.34e-01
Meiotic recombination	30	9.12e-01	-0.011700	9.74e-01
APC/C:Cdc20 mediated degradation of Cyclin B	19	9.30e-01	0.011700	9.81e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	9.40e-01	-0.011600	9.83e-01
Post-translational modification: synthesis of GPI-anchored proteins	60	8.78e-01	0.011500	9.60e-01
Frs2-mediated activation	12	9.45e-01	0.011400	9.83e-01
Cilium Assembly	179	7.94e-01	-0.011400	9.27e-01
Synthesis of PIPs at the late endosome membrane	10	9.51e-01	-0.011300	9.83e-01
Cargo recognition for clathrin-mediated endocytosis	81	8.61e-01	0.011200	9.56e-01
Gastrin-CREB signalling pathway via PKC and MAPK	15	9.42e-01	-0.010900	9.83e-01
FGFR1 ligand binding and activation	10	9.53e-01	0.010900	9.83e-01
Metabolism of steroid hormones	25	9.27e-01	-0.010600	9.81e-01
Antiviral mechanism by IFN-stimulated genes	71	8.77e-01	-0.010600	9.60e-01
CD28 dependent PI3K/Akt signaling	19	9.37e-01	-0.010500	9.82e-01
RHOV GTPase cycle	35	9.15e-01	-0.010500	9.74e-01
Mitotic Telophase/Cytokinesis	13	9.50e-01	0.010100	9.83e-01
Polo-like kinase mediated events	15	9.47e-01	0.009960	9.83e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	9.39e-01	-0.009950	9.82e-01
CD28 co-stimulation	28	9.28e-01	0.009920	9.81e-01
Signaling by ERBB2 KD Mutants	21	9.38e-01	-0.009800	9.82e-01
RHOQ GTPase cycle	55	9.00e-01	0.009750	9.70e-01
Signaling by Hedgehog	130	8.53e-01	0.009420	9.54e-01
Mitotic Prophase	86	8.80e-01	-0.009390	9.61e-01
Glycosphingolipid metabolism	40	9.19e-01	-0.009320	9.76e-01
Processing of DNA double-strand break ends	58	9.04e-01	0.009140	9.71e-01
Incretin synthesis, secretion, and inactivation	16	9.50e-01	-0.009110	9.83e-01
PCNA-Dependent Long Patch Base Excision Repair	16	9.50e-01	-0.009040	9.83e-01
ADP signalling through P2Y purinoceptor 1	15	9.52e-01	0.009040	9.83e-01
Processive synthesis on the C-strand of the telomere	16	9.51e-01	-0.008880	9.83e-01
Gap junction assembly	20	9.46e-01	0.008820	9.83e-01
Homology Directed Repair	89	8.95e-01	0.008130	9.67e-01
Constitutive Signaling by Aberrant PI3K in Cancer	59	9.15e-01	0.008050	9.74e-01
Glycosaminoglycan metabolism	105	8.89e-01	-0.007870	9.66e-01
RNA Polymerase III Abortive And Retractive Initiation	38	9.38e-01	-0.007340	9.82e-01
RNA Polymerase III Transcription	38	9.38e-01	-0.007340	9.82e-01
Signaling by NTRKs	117	8.96e-01	0.007040	9.67e-01
Transcriptional Regulation by NPAS4	28	9.49e-01	-0.007010	9.83e-01
Gap junction degradation	12	9.67e-01	0.006940	9.89e-01
RNA Polymerase II Transcription	906	7.27e-01	-0.006920	9.02e-01
TRP channels	18	9.60e-01	0.006880	9.86e-01
Glucose metabolism	85	9.13e-01	0.006850	9.74e-01
Interleukin-7 signaling	16	9.62e-01	0.006800	9.86e-01
Homologous DNA Pairing and Strand Exchange	40	9.41e-01	-0.006730	9.83e-01
AKT phosphorylates targets in the nucleus	10	9.71e-01	-0.006620	9.91e-01
Signaling by KIT in disease	18	9.62e-01	0.006490	9.86e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	18	9.62e-01	0.006490	9.86e-01
Base Excision Repair	44	9.44e-01	-0.006110	9.83e-01
Generic Transcription Pathway	802	7.77e-01	-0.005940	9.22e-01
Keratinization	41	9.49e-01	-0.005800	9.83e-01
Regulation of localization of FOXO transcription factors	11	9.74e-01	0.005730	9.91e-01
Nicotinamide salvaging	16	9.68e-01	0.005730	9.89e-01
HIV elongation arrest and recovery	32	9.55e-01	0.005710	9.84e-01
Pausing and recovery of HIV elongation	32	9.55e-01	0.005710	9.84e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	38	9.52e-01	0.005610	9.83e-01
Diseases of DNA Double-Strand Break Repair	38	9.52e-01	0.005610	9.83e-01
HIV Infection	200	8.92e-01	-0.005600	9.66e-01
HDR through Single Strand Annealing (SSA)	36	9.55e-01	-0.005460	9.84e-01
Impaired BRCA2 binding to RAD51	33	9.57e-01	0.005390	9.85e-01
Hedgehog ‘off’ state	96	9.36e-01	0.004720	9.82e-01
DNA Double-Strand Break Repair	116	9.31e-01	-0.004650	9.81e-01
Acyl chain remodelling of PE	18	9.74e-01	-0.004510	9.91e-01
Nuclear Receptor transcription pathway	42	9.63e-01	-0.004170	9.86e-01
IRF3-mediated induction of type I IFN	10	9.83e-01	0.003990	9.91e-01
Cytoprotection by HMOX1	51	9.63e-01	0.003750	9.86e-01
Signaling by FGFR2 IIIa TM	18	9.79e-01	0.003620	9.91e-01
VEGFR2 mediated vascular permeability	24	9.76e-01	-0.003490	9.91e-01
Global Genome Nucleotide Excision Repair (GG-NER)	71	9.62e-01	0.003290	9.86e-01
Telomere Maintenance	67	9.66e-01	0.003050	9.88e-01
Cleavage of the damaged pyrimidine	20	9.83e-01	0.002820	9.91e-01
Depyrimidination	20	9.83e-01	0.002820	9.91e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	20	9.83e-01	0.002820	9.91e-01
DAP12 signaling	21	9.82e-01	0.002810	9.91e-01
HCMV Early Events	75	9.68e-01	-0.002670	9.89e-01
Translesion Synthesis by POLH	16	9.85e-01	-0.002630	9.93e-01
Signaling by ERBB2	40	9.79e-01	0.002380	9.91e-01
HDR through Homologous Recombination (HRR)	55	9.76e-01	-0.002380	9.91e-01
Gap junction trafficking	31	9.82e-01	0.002280	9.91e-01
Defective B4GALT7 causes EDS, progeroid type	16	9.88e-01	-0.002090	9.94e-01
rRNA processing in the mitochondrion	20	9.89e-01	0.001830	9.94e-01
Phosphorylation of the APC/C	17	9.90e-01	-0.001780	9.94e-01
Protein ubiquitination	60	9.81e-01	0.001770	9.91e-01
Interleukin-17 signaling	61	9.81e-01	0.001720	9.91e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	83	9.79e-01	0.001650	9.91e-01
RNA Polymerase I Transcription Initiation	44	9.86e-01	-0.001560	9.93e-01
Estrogen-dependent gene expression	87	9.81e-01	-0.001510	9.91e-01
ER Quality Control Compartment (ERQC)	19	9.92e-01	0.001400	9.95e-01
Presynaptic phase of homologous DNA pairing and strand exchange	37	9.89e-01	-0.001350	9.94e-01
Phospholipid metabolism	172	9.78e-01	0.001240	9.91e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	11	9.96e-01	-0.000930	9.98e-01
Metabolism of water-soluble vitamins and cofactors	105	9.92e-01	-0.000576	9.95e-01
Transcription of E2F targets under negative control by DREAM complex	19	9.97e-01	-0.000437	9.98e-01
CD209 (DC-SIGN) signaling	16	9.98e-01	-0.000417	9.98e-01
Signaling by NTRK1 (TRKA)	99	9.96e-01	0.000280	9.98e-01

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Detailed Gene set reports

Metallothioneins bind metals

Metallothioneins bind metals

	687
set	Metallothioneins bind metals
setSize	10
pANOVA	1.22e-05
s.dist	0.799
p.adjustANOVA	0.00135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT1A	5213
MT1B	5213
MT1E	5213
MT1F	5213
MT1G	5213
MT1H	5213
MT1M	5213
MT1X	5213
MT2A	5213
MT3	5213

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT1A	5213
MT1B	5213
MT1E	5213
MT1F	5213
MT1G	5213
MT1H	5213
MT1M	5213
MT1X	5213
MT2A	5213
MT3	5213

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Response to metal ions

Response to metal ions

	1075
set	Response to metal ions
setSize	13
pANOVA	8.26e-06
s.dist	0.714
p.adjustANOVA	0.000994

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSRP1	6201
MT1A	5213
MT1B	5213
MT1E	5213
MT1F	5213
MT1G	5213
MT1H	5213
MT1M	5213
MT1X	5213
MT2A	5213
MT3	5213
SNCB	2203
MTF1	-189

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSRP1	6201
MT1A	5213
MT1B	5213
MT1E	5213
MT1F	5213
MT1G	5213
MT1H	5213
MT1M	5213
MT1X	5213
MT2A	5213
MT3	5213
SNCB	2203
MTF1	-189

---

Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine

	286
set	Degradation of cysteine and homocysteine
setSize	11
pANOVA	0.000313
s.dist	-0.628
p.adjustANOVA	0.0161

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADO	-6181
GADL1	-6036
TSTD1	-5883
MPST	-5618
TST	-5617
CDO1	-5398
SLC25A10	-5380
CSAD	-5217
CTH	-5125
TXN2	-3960
GOT2	5908

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADO	-6181
GADL1	-6036
TSTD1	-5883
MPST	-5618
TST	-5617
CDO1	-5398
SLC25A10	-5380
CSAD	-5217
CTH	-5125
TXN2	-3960
GOT2	5908

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	229
set	Crosslinking of collagen fibrils
setSize	16
pANOVA	0.000119
s.dist	0.556
p.adjustANOVA	0.00715

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	6572
LOXL2	6559
LOXL1	5899
COL4A2	5750
COL4A1	5416
PXDN	4969
COL4A4	4924
TLL1	4528
BMP1	4346
COL1A2	3999
LOXL4	3976
COL4A3	2590
LOX	1160
TLL2	-530
COL1A1	-1126
PCOLCE	-1869

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	6572
LOXL2	6559
LOXL1	5899
COL4A2	5750
COL4A1	5416
PXDN	4969
COL4A4	4924
TLL1	4528
BMP1	4346
COL1A2	3999
LOXL4	3976
COL4A3	2590
LOX	1160
TLL2	-530
COL1A1	-1126
PCOLCE	-1869

---

Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases

	42
set	Activation of Matrix Metalloproteinases
setSize	22
pANOVA	1.3e-05
s.dist	0.537
p.adjustANOVA	0.00135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTSG	6491.0
MMP11	6348.0
MMP17	6324.0
MMP10	6309.0
MMP15	6061.0
TIMP2	5888.0
MMP1	5303.0
SPOCK3	5162.0
TPSAB1	4774.5
CTRB1	4659.5
CTRB2	4659.5
MMP14	4322.0
KLKB1	4313.0
MMP2	3894.0
MMP25	3746.0
MMP13	3610.0
COL18A1	3012.0
PRSS1	2078.0
PRSS2	2078.0
CTSV	-2893.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTSG	6491.0
MMP11	6348.0
MMP17	6324.0
MMP10	6309.0
MMP15	6061.0
TIMP2	5888.0
MMP1	5303.0
SPOCK3	5162.0
TPSAB1	4774.5
CTRB1	4659.5
CTRB2	4659.5
MMP14	4322.0
KLKB1	4313.0
MMP2	3894.0
MMP25	3746.0
MMP13	3610.0
COL18A1	3012.0
PRSS1	2078.0
PRSS2	2078.0
CTSV	-2893.0
MMP24	-3687.0
MMP16	-6675.0

---

Collagen degradation

Collagen degradation

	207
set	Collagen degradation
setSize	47
pANOVA	8.14e-10
s.dist	0.518
p.adjustANOVA	4.35e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL16A1	6569
COL12A1	6510
COL3A1	6495
COL9A1	6422
MMP11	6348
MMP10	6309
MMP12	6309
COL6A1	6124
MMP15	6061
COL15A1	6019
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
COL8A1	5448
COL4A1	5416
MMP1	5303
COL4A4	4924

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL16A1	6569
COL12A1	6510
COL3A1	6495
COL9A1	6422
MMP11	6348
MMP10	6309
MMP12	6309
COL6A1	6124
MMP15	6061
COL15A1	6019
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
COL8A1	5448
COL4A1	5416
MMP1	5303
COL4A4	4924
MMP20	4590
COL11A1	4427
ADAM10	4420
MMP14	4322
COL6A3	4052
COL1A2	3999
MMP2	3894
MMP19	3874
COL2A1	3754
MMP13	3610
COL25A1	3400
COL18A1	3012
COL4A3	2590
ADAM9	2318
PRSS2	2078
ADAM17	1500
CTSB	1313
COL6A5	1224
COL8A2	939
COL13A1	-805
COL14A1	-867
COL1A1	-1126
PHYKPL	-1595
CTSL	-2893
COL5A3	-3320
COL11A2	-5451
COL26A1	-6851

---

Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand

	157
set	Caspase activation via Death Receptors in the presence of ligand
setSize	12
pANOVA	0.00196
s.dist	0.516
p.adjustANOVA	0.0469

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LY96	5924.0
TRAF2	5868.0
CFLAR	5476.0
CASP8	5364.0
TNFSF10	4666.0
FADD	4635.0
CD14	4233.0
TLR4	2597.0
TICAM1	2528.0
RIPK1	1485.0
TNFRSF10B	-968.5
FAS	-2115.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LY96	5924.0
TRAF2	5868.0
CFLAR	5476.0
CASP8	5364.0
TNFSF10	4666.0
FADD	4635.0
CD14	4233.0
TLR4	2597.0
TICAM1	2528.0
RIPK1	1485.0
TNFRSF10B	-968.5
FAS	-2115.0

---

GRB2:SOS provides linkage to MAPK signaling for Integrins

GRB2:SOS provides linkage to MAPK signaling for Integrins

	456
set	GRB2:SOS provides linkage to MAPK signaling for Integrins
setSize	12
pANOVA	0.002
s.dist	0.515
p.adjustANOVA	0.0469

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	6030
FN1	5695
APBB1IP	5429
SOS1	5406
PTK2	4968
RAP1A	4333
VWF	3558
TLN1	3550
ITGA2B	3195
GRB2	2141
RAP1B	-2189
SRC	-2498

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	6030
FN1	5695
APBB1IP	5429
SOS1	5406
PTK2	4968
RAP1A	4333
VWF	3558
TLN1	3550
ITGA2B	3195
GRB2	2141
RAP1B	-2189
SRC	-2498

---

Collagen chain trimerization

Collagen chain trimerization

	206
set	Collagen chain trimerization
setSize	30
pANOVA	1.35e-06
s.dist	0.51
p.adjustANOVA	0.000177

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL16A1	6569
COL12A1	6510
COL3A1	6495
COL9A1	6422
COL6A1	6124
COL15A1	6019
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
COL8A1	5448
COL4A1	5416
COL4A4	4924
COL11A1	4427
COL6A3	4052
COL1A2	3999
COL2A1	3754
COL25A1	3400

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL16A1	6569
COL12A1	6510
COL3A1	6495
COL9A1	6422
COL6A1	6124
COL15A1	6019
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
COL8A1	5448
COL4A1	5416
COL4A4	4924
COL11A1	4427
COL6A3	4052
COL1A2	3999
COL2A1	3754
COL25A1	3400
COL18A1	3012
COL4A3	2590
COL6A5	1224
COL8A2	939
COL13A1	-805
COL14A1	-867
COL1A1	-1126
COL5A3	-3320
COL11A2	-5451
COL26A1	-6851

---

Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling

	63
set	Advanced glycosylation endproduct receptor signaling
setSize	12
pANOVA	0.00278
s.dist	0.499
p.adjustANOVA	0.0549

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	6552.0
AGER	6345.0
S100B	6301.0
MAPK1	6139.0
LGALS3	6064.0
SAA1	6051.0
CAPZA1	5904.0
HMGB1	2957.5
PRKCSH	781.0
DDOST	-135.0
MAPK3	-3298.0
CAPZA2	-5384.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	6552.0
AGER	6345.0
S100B	6301.0
MAPK1	6139.0
LGALS3	6064.0
SAA1	6051.0
CAPZA1	5904.0
HMGB1	2957.5
PRKCSH	781.0
DDOST	-135.0
MAPK3	-3298.0
CAPZA2	-5384.0

---

Cholesterol biosynthesis

Cholesterol biosynthesis

	185
set	Cholesterol biosynthesis
setSize	24
pANOVA	3.63e-05
s.dist	0.487
p.adjustANOVA	0.00276

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CYP51A1	5635
SC5D	5547
FDPS	5537
SQLE	5511
MVD	4835
LSS	4754
SREBF1	4524
ACAT2	4443
DHCR24	4285
FDFT1	4195
PMVK	4139
HMGCS1	3827
MSMO1	3806
MVK	3001
SREBF2	2894
PLPP6	2702
DHCR7	2364
HSD17B7	2234
GGPS1	1743
TM7SF2	1574

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CYP51A1	5635
SC5D	5547
FDPS	5537
SQLE	5511
MVD	4835
LSS	4754
SREBF1	4524
ACAT2	4443
DHCR24	4285
FDFT1	4195
PMVK	4139
HMGCS1	3827
MSMO1	3806
MVK	3001
SREBF2	2894
PLPP6	2702
DHCR7	2364
HSD17B7	2234
GGPS1	1743
TM7SF2	1574
HMGCR	1172
LBR	-212
IDI1	-1215
ARV1	-2707

---

Collagen biosynthesis and modifying enzymes

Collagen biosynthesis and modifying enzymes

	205
set	Collagen biosynthesis and modifying enzymes
setSize	50
pANOVA	4.06e-09
s.dist	0.481
p.adjustANOVA	9.77e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL16A1	6569
COL12A1	6510
COL3A1	6495
ADAMTS14	6474
COL9A1	6422
P3H2	6297
COL6A1	6124
SERPINH1	6040
COL15A1	6019
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
P4HA2	5466
COL8A1	5448
P3H3	5425
COL4A1	5416
P4HA1	5379

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL16A1	6569
COL12A1	6510
COL3A1	6495
ADAMTS14	6474
COL9A1	6422
P3H2	6297
COL6A1	6124
SERPINH1	6040
COL15A1	6019
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
P4HA2	5466
COL8A1	5448
P3H3	5425
COL4A1	5416
P4HA1	5379
P4HA3	5349
PCOLCE2	4967
COL4A4	4924
TLL1	4528
COL11A1	4427
BMP1	4346
COL6A3	4052
COL1A2	3999
COL2A1	3754
COL25A1	3400
ADAMTS2	3368
PPIB	3220
COL18A1	3012
COL4A3	2590
P4HB	1482
COL6A5	1224
COL8A2	939
PLOD2	785
CRTAP	765
COLGALT1	-339
TLL2	-530
COL13A1	-805
COL14A1	-867
COL1A1	-1126
PCOLCE	-1869
P3H1	-2177
COL5A3	-3320
PLOD3	-3767
COL11A2	-5451
COL26A1	-6851

---

Cell-extracellular matrix interactions

Cell-extracellular matrix interactions

	171
set	Cell-extracellular matrix interactions
setSize	18
pANOVA	0.000442
s.dist	0.478
p.adjustANOVA	0.0211

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB1	6443
ARHGEF6	6295
FBLIM1	5993
ACTN1	5856
FLNA	5704
ACTB	5657
FLNC	5144
PARVB	5028
VASP	4718
PXN	4365
ILK	3316
ACTG1	3081
LIMS1	2268
LIMS2	-539
RSU1	-1301
TESK1	-1600
FERMT2	-2605
PARVA	-2903

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB1	6443
ARHGEF6	6295
FBLIM1	5993
ACTN1	5856
FLNA	5704
ACTB	5657
FLNC	5144
PARVB	5028
VASP	4718
PXN	4365
ILK	3316
ACTG1	3081
LIMS1	2268
LIMS2	-539
RSU1	-1301
TESK1	-1600
FERMT2	-2605
PARVA	-2903

---

Nitric oxide stimulates guanylate cyclase

Nitric oxide stimulates guanylate cyclase

	774
set	Nitric oxide stimulates guanylate cyclase
setSize	13
pANOVA	0.0029
s.dist	-0.477
p.adjustANOVA	0.0557

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDE10A	-6870
PDE2A	-6772
NOS1	-6737
PDE9A	-6493
KCNMB4	-6453
NOS3	-5946
PRKG1	-5023
GUCY1A2	-4491
PDE5A	-3900
PDE1A	-3427
KCNMA1	1025
ITPR1	4484
PDE1B	6484

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDE10A	-6870
PDE2A	-6772
NOS1	-6737
PDE9A	-6493
KCNMB4	-6453
NOS3	-5946
PRKG1	-5023
GUCY1A2	-4491
PDE5A	-3900
PDE1A	-3427
KCNMA1	1025
ITPR1	4484
PDE1B	6484

---

p130Cas linkage to MAPK signaling for integrins

p130Cas linkage to MAPK signaling for integrins

	1424
set	p130Cas linkage to MAPK signaling for integrins
setSize	12
pANOVA	0.00653
s.dist	0.453
p.adjustANOVA	0.0873

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	6030
FN1	5695
APBB1IP	5429
PTK2	4968
RAP1A	4333
VWF	3558
TLN1	3550
ITGA2B	3195
CRK	1992
BCAR1	549
RAP1B	-2189
SRC	-2498

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	6030
FN1	5695
APBB1IP	5429
PTK2	4968
RAP1A	4333
VWF	3558
TLN1	3550
ITGA2B	3195
CRK	1992
BCAR1	549
RAP1B	-2189
SRC	-2498

---

MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)

	718
set	MyD88 deficiency (TLR2/4)
setSize	11
pANOVA	0.0126
s.dist	0.434
p.adjustANOVA	0.13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD36	6235.0
LY96	5924.0
CD14	4233.0
TIRAP	3575.0
HMGB1	2957.5
TLR2	2631.0
TLR4	2597.0
MYD88	2560.0
TLR6	2513.0
S100A1	-397.0
S100A8	-2517.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD36	6235.0
LY96	5924.0
CD14	4233.0
TIRAP	3575.0
HMGB1	2957.5
TLR2	2631.0
TLR4	2597.0
MYD88	2560.0
TLR6	2513.0
S100A1	-397.0
S100A8	-2517.0

---

Integrin cell surface interactions

Integrin cell surface interactions

	572
set	Integrin cell surface interactions
setSize	63
pANOVA	2.72e-09
s.dist	0.433
p.adjustANOVA	7.85e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL16A1	6569
FBN1	6514
COL3A1	6495
ITGB1	6443
IBSP	6438
COL9A1	6422
TNC	6360
COL6A1	6124
VCAM1	6111
ITGA1	6054
ITGB3	6030
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
FN1	5695
COL5A1	5613
ITGA2	5477
COL8A1	5448

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL16A1	6569
FBN1	6514
COL3A1	6495
ITGB1	6443
IBSP	6438
COL9A1	6422
TNC	6360
COL6A1	6124
VCAM1	6111
ITGA1	6054
ITGB3	6030
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
FN1	5695
COL5A1	5613
ITGA2	5477
COL8A1	5448
COL4A1	5416
ITGB2	5190
AGRN	5015
COL4A4	4924
ITGA11	4461
ITGA9	4161
JAM3	4115
COL6A3	4052
COL1A2	3999
COL2A1	3754
ITGA3	3559
VWF	3558
ITGA4	3307
ITGA2B	3195
ICAM5	3173
JAM2	3112
COL18A1	3012
ITGAV	2936
ITGAX	2914
CD44	2795
ITGA8	2794
COL4A3	2590
ICAM3	2116
LUM	1848
BSG	1537
THBS1	1489
COL6A5	1224
ITGA6	1198
COL8A2	939
ICAM2	832
ITGAE	558
COL13A1	-805
CDH1	-1085
COL1A1	-1126
ITGA5	-1258
CD47	-2524
COL5A3	-3320
ICAM4	-4333
ITGB8	-4519
ITGB7	-5129
ITGA10	-5691
ITGAL	-5799
ITGA7	-6769

---

GABA synthesis, release, reuptake and degradation

GABA synthesis, release, reuptake and degradation

	449
set	GABA synthesis, release, reuptake and degradation
setSize	13
pANOVA	0.00738
s.dist	-0.429
p.adjustANOVA	0.0947

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC6A1	-6554
SNAP25	-6420
ABAT	-5784
VAMP2	-5246
RAB3A	-5009
ALDH5A1	-3503
RIMS1	-3402
SLC6A11	-2777
SLC6A13	-2181
STXBP1	-1109
SYT1	389
SLC6A12	633
HSPA8	1045

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC6A1	-6554
SNAP25	-6420
ABAT	-5784
VAMP2	-5246
RAB3A	-5009
ALDH5A1	-3503
RIMS1	-3402
SLC6A11	-2777
SLC6A13	-2181
STXBP1	-1109
SYT1	389
SLC6A12	633
HSPA8	1045

---

Formation of axial mesoderm

Formation of axial mesoderm

	416
set	Formation of axial mesoderm
setSize	10
pANOVA	0.0211
s.dist	-0.421
p.adjustANOVA	0.161

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TCF7	-6368
SMAD2	-6172
FOXH1	-5979
SMAD3	-5898
SHH	-5814
FOXA2	-4320
TEAD4	-3261
YAP1	-2305
CTNNB1	4496
LEF1	5442

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TCF7	-6368
SMAD2	-6172
FOXH1	-5979
SMAD3	-5898
SHH	-5814
FOXA2	-4320
TEAD4	-3261
YAP1	-2305
CTNNB1	4496
LEF1	5442

---

ECM proteoglycans

ECM proteoglycans

	337
set	ECM proteoglycans
setSize	61
pANOVA	1.71e-08
s.dist	0.418
p.adjustANOVA	3.08e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SERPINE1	6556
APP	6552
COL3A1	6495
TGFB3	6444
ITGB1	6443
IBSP	6438
COL9A1	6422
TNC	6360
LAMA1	6214
TGFB2	6193
TNR	6164
LRP4	6163
COL6A1	6124
ITGB3	6030
COL9A3	5976
MATN4	5901
COL6A2	5897
COL5A2	5828
COL4A2	5750
FN1	5695

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SERPINE1	6556
APP	6552
COL3A1	6495
TGFB3	6444
ITGB1	6443
IBSP	6438
COL9A1	6422
TNC	6360
LAMA1	6214
TGFB2	6193
TNR	6164
LRP4	6163
COL6A1	6124
ITGB3	6030
COL9A3	5976
MATN4	5901
COL6A2	5897
COL5A2	5828
COL4A2	5750
FN1	5695
HAPLN1	5620
COL5A1	5613
ITGA2	5477
COL4A1	5416
ASPN	5374
AGRN	5015
COL4A4	4924
FMOD	4682
ITGA9	4161
COL6A3	4052
LAMC1	4011
COL1A2	3999
COL2A1	3754
ITGA2B	3195
VCAN	3060
ITGAV	2936
ITGAX	2914
ITGA8	2794
SPARC	2592
COL4A3	2590
LAMB1	2477
LAMA2	2052
LUM	1848
LAMA4	1602
TGFB1	1523
COL6A5	1224
TNN	576
BGN	333
COL1A1	-1126
LAMB2	-2330
COL5A3	-3320
DCN	-3443
DMP1	-3898
DAG1	-4228
BCAN	-4737
LAMA3	-4762
PTPRS	-4847
TNXB	-5245
NCAM1	-5453
MATN3	-6738
ITGA7	-6769

---

Other semaphorin interactions

Other semaphorin interactions

	810
set	Other semaphorin interactions
setSize	16
pANOVA	0.00507
s.dist	0.405
p.adjustANOVA	0.0738

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PLXNA4	6512
PLXNB3	6492
ITGB1	6443
ITGA1	6054
SEMA4A	6017
SEMA6A	4472
SEMA6D	4038
SEMA5A	3997
PLXND1	3634
PLXNA1	3386
SEMA3E	3036
PLXNA2	601
SEMA4D	-818
SEMA7A	-3280
PLXNC1	-3745
TREM2	-5960

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PLXNA4	6512
PLXNB3	6492
ITGB1	6443
ITGA1	6054
SEMA4A	6017
SEMA6A	4472
SEMA6D	4038
SEMA5A	3997
PLXND1	3634
PLXNA1	3386
SEMA3E	3036
PLXNA2	601
SEMA4D	-818
SEMA7A	-3280
PLXNC1	-3745
TREM2	-5960

---

Signal transduction by L1

Signal transduction by L1

	1147
set	Signal transduction by L1
setSize	21
pANOVA	0.00162
s.dist	0.397
p.adjustANOVA	0.0436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB1	6443.0
MAPK1	6139.0
ITGB3	6030.0
NRP1	5956.0
L1CAM	5812.0
FGFR1	5667.0
MAP2K2	4448.0
ITGA9	4161.0
ITGA2B	3195.0
CSNK2A1	3114.5
ITGAV	2936.0
CSNK2B	2473.0
VAV2	2462.0
CSNK2A2	2456.0
PAK1	2423.0
RAC1	439.0
MAP2K1	182.0
ITGA5	-1258.0
EGFR	-1736.0
MAPK3	-3298.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB1	6443.0
MAPK1	6139.0
ITGB3	6030.0
NRP1	5956.0
L1CAM	5812.0
FGFR1	5667.0
MAP2K2	4448.0
ITGA9	4161.0
ITGA2B	3195.0
CSNK2A1	3114.5
ITGAV	2936.0
CSNK2B	2473.0
VAV2	2462.0
CSNK2A2	2456.0
PAK1	2423.0
RAC1	439.0
MAP2K1	182.0
ITGA5	-1258.0
EGFR	-1736.0
MAPK3	-3298.0
NCAM1	-5453.0

---

IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)

	539
set	IRAK4 deficiency (TLR2/4)
setSize	12
pANOVA	0.0228
s.dist	0.38
p.adjustANOVA	0.165

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD36	6235.0
LY96	5924.0
CD14	4233.0
TIRAP	3575.0
HMGB1	2957.5
TLR2	2631.0
TLR4	2597.0
MYD88	2560.0
TLR6	2513.0
S100A1	-397.0
IRAK4	-1678.0
S100A8	-2517.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD36	6235.0
LY96	5924.0
CD14	4233.0
TIRAP	3575.0
HMGB1	2957.5
TLR2	2631.0
TLR4	2597.0
MYD88	2560.0
TLR6	2513.0
S100A1	-397.0
IRAK4	-1678.0
S100A8	-2517.0

---

Collagen formation

Collagen formation

	208
set	Collagen formation
setSize	68
pANOVA	6.69e-08
s.dist	0.379
p.adjustANOVA	9.65e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	6572
COL16A1	6569
LOXL2	6559
COL12A1	6510
COL3A1	6495
ADAMTS14	6474
COL9A1	6422
P3H2	6297
COL6A1	6124
SERPINH1	6040
COL15A1	6019
COL9A3	5976
LOXL1	5899
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
P4HA2	5466
COL8A1	5448

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	6572
COL16A1	6569
LOXL2	6559
COL12A1	6510
COL3A1	6495
ADAMTS14	6474
COL9A1	6422
P3H2	6297
COL6A1	6124
SERPINH1	6040
COL15A1	6019
COL9A3	5976
LOXL1	5899
COL6A2	5897
COL5A2	5828
COL23A1	5824
COL4A2	5750
COL5A1	5613
P4HA2	5466
COL8A1	5448
P3H3	5425
COL4A1	5416
P4HA1	5379
P4HA3	5349
PXDN	4969
PCOLCE2	4967
COL4A4	4924
MMP20	4590
TLL1	4528
COL11A1	4427
BMP1	4346
COL6A3	4052
COL1A2	3999
LOXL4	3976
COL2A1	3754
MMP13	3610
COL25A1	3400
ADAMTS2	3368
PPIB	3220
COL18A1	3012
COL4A3	2590
P4HB	1482
CTSB	1313
COL6A5	1224
ITGA6	1198
LOX	1160
COL8A2	939
PLOD2	785
CRTAP	765
COLGALT1	-339
TLL2	-530
COL13A1	-805
COL14A1	-867
COL1A1	-1126
LAMC2	-1345
PCOLCE	-1869
P3H1	-2177
CTSL	-2893
CTSV	-2893
COL5A3	-3320
DST	-3685
PLOD3	-3767
PLEC	-4188
LAMA3	-4762
COL11A2	-5451
ITGB4	-5698
LAMB3	-6219
COL26A1	-6851

---

Integrin signaling

Integrin signaling

	573
set	Integrin signaling
setSize	23
pANOVA	0.00168
s.dist	0.379
p.adjustANOVA	0.0436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	6030
CSK	5838
FN1	5695
RASGRP1	5491
APBB1IP	5429
SOS1	5406
PTK2	4968
RASGRP2	4488
RAP1A	4333
VWF	3558
TLN1	3550
ITGA2B	3195
SHC1	2571
RAPGEF3	2319
GRB2	2141
CRK	1992
BCAR1	549
SYK	-419
AKT1	-682
RAP1B	-2189

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	6030
CSK	5838
FN1	5695
RASGRP1	5491
APBB1IP	5429
SOS1	5406
PTK2	4968
RASGRP2	4488
RAP1A	4333
VWF	3558
TLN1	3550
ITGA2B	3195
SHC1	2571
RAPGEF3	2319
GRB2	2141
CRK	1992
BCAR1	549
SYK	-419
AKT1	-682
RAP1B	-2189
SRC	-2498
PDPK1	-2857
PTPN1	-4248

---

Sulfur amino acid metabolism

Sulfur amino acid metabolism

	1243
set	Sulfur amino acid metabolism
setSize	23
pANOVA	0.00169
s.dist	-0.378
p.adjustANOVA	0.0436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADO	-6181
GADL1	-6036
CBS	-5930
TSTD1	-5883
MPST	-5618
TST	-5617
MRI1	-5508
CDO1	-5398
SLC25A10	-5380
CSAD	-5217
CTH	-5125
MTR	-4997
TXN2	-3960
GOT1	-3920
ADI1	-3263
MTRR	-2816
MTAP	-944
BHMT2	-350
MAT1A	1244
APIP	3853

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADO	-6181
GADL1	-6036
CBS	-5930
TSTD1	-5883
MPST	-5618
TST	-5617
MRI1	-5508
CDO1	-5398
SLC25A10	-5380
CSAD	-5217
CTH	-5125
MTR	-4997
TXN2	-3960
GOT1	-3920
ADI1	-3263
MTRR	-2816
MTAP	-944
BHMT2	-350
MAT1A	1244
APIP	3853
AHCY	4003
ENOPH1	4467
GOT2	5908

---

Triglyceride biosynthesis

Triglyceride biosynthesis

	1373
set	Triglyceride biosynthesis
setSize	10
pANOVA	0.039
s.dist	-0.377
p.adjustANOVA	0.218

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GK	-6808
GK2	-6808
GPAT2	-6482
DGAT2	-5232
LPIN3	-4164
GPAM	-3684
DGAT1	-2947
LPIN2	122
MOGAT1	2689
LPIN1	6120

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GK	-6808
GK2	-6808
GPAT2	-6482
DGAT2	-5232
LPIN3	-4164
GPAM	-3684
DGAT1	-2947
LPIN2	122
MOGAT1	2689
LPIN1	6120

---

Syndecan interactions

Syndecan interactions

	1247
set	Syndecan interactions
setSize	24
pANOVA	0.00141
s.dist	0.377
p.adjustANOVA	0.0436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL3A1	6495
ITGB1	6443
TNC	6360
SDC4	6093
ITGB3	6030
ACTN1	5856
COL5A2	5828
FN1	5695
PRKCA	5679
COL5A1	5613
ITGA2	5477
COL1A2	3999
CASK	3699
ITGAV	2936
TGFB1	1523
THBS1	1489
ITGA6	1198
FGF2	-333
COL1A1	-1126
SDC3	-3301

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL3A1	6495
ITGB1	6443
TNC	6360
SDC4	6093
ITGB3	6030
ACTN1	5856
COL5A2	5828
FN1	5695
PRKCA	5679
COL5A1	5613
ITGA2	5477
COL1A2	3999
CASK	3699
ITGAV	2936
TGFB1	1523
THBS1	1489
ITGA6	1198
FGF2	-333
COL1A1	-1126
SDC3	-3301
COL5A3	-3320
SDC2	-4570
TRAPPC4	-5338
ITGB4	-5698

---

cGMP effects

cGMP effects

	1414
set	cGMP effects
setSize	10
pANOVA	0.0409
s.dist	-0.373
p.adjustANOVA	0.22

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDE10A	-6870
PDE2A	-6772
PDE9A	-6493
KCNMB4	-6453
PRKG1	-5023
PDE5A	-3900
PDE1A	-3427
KCNMA1	1025
ITPR1	4484
PDE1B	6484

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDE10A	-6870
PDE2A	-6772
PDE9A	-6493
KCNMB4	-6453
PRKG1	-5023
PDE5A	-3900
PDE1A	-3427
KCNMA1	1025
ITPR1	4484
PDE1B	6484

---

The NLRP3 inflammasome

The NLRP3 inflammasome

	1304
set	The NLRP3 inflammasome
setSize	13
pANOVA	0.0207
s.dist	0.371
p.adjustANOVA	0.16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	6552
PYCARD	5896
NFKB1	5585
HMOX1	5332
PANX1	5102
SUGT1	4282
RELA	3964
PSTPIP1	3544
P2RX7	2829
HSP90AB1	-1342
TXNIP	-2753
TXN	-2909
NFKB2	-5863

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	6552
PYCARD	5896
NFKB1	5585
HMOX1	5332
PANX1	5102
SUGT1	4282
RELA	3964
PSTPIP1	3544
P2RX7	2829
HSP90AB1	-1342
TXNIP	-2753
TXN	-2909
NFKB2	-5863

---

Assembly of collagen fibrils and other multimeric structures

Assembly of collagen fibrils and other multimeric structures

	93
set	Assembly of collagen fibrils and other multimeric structures
setSize	47
pANOVA	2.46e-05
s.dist	0.356
p.adjustANOVA	0.00222

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	6572
LOXL2	6559
COL12A1	6510
COL3A1	6495
COL9A1	6422
COL6A1	6124
COL15A1	6019
COL9A3	5976
LOXL1	5899
COL6A2	5897
COL5A2	5828
COL4A2	5750
COL5A1	5613
COL8A1	5448
COL4A1	5416
PXDN	4969
COL4A4	4924
MMP20	4590
TLL1	4528
COL11A1	4427

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	6572
LOXL2	6559
COL12A1	6510
COL3A1	6495
COL9A1	6422
COL6A1	6124
COL15A1	6019
COL9A3	5976
LOXL1	5899
COL6A2	5897
COL5A2	5828
COL4A2	5750
COL5A1	5613
COL8A1	5448
COL4A1	5416
PXDN	4969
COL4A4	4924
MMP20	4590
TLL1	4528
COL11A1	4427
BMP1	4346
COL6A3	4052
COL1A2	3999
LOXL4	3976
COL2A1	3754
MMP13	3610
COL18A1	3012
COL4A3	2590
CTSB	1313
COL6A5	1224
ITGA6	1198
LOX	1160
COL8A2	939
TLL2	-530
COL14A1	-867
COL1A1	-1126
LAMC2	-1345
PCOLCE	-1869
CTSL	-2893
CTSV	-2893
COL5A3	-3320
DST	-3685
PLEC	-4188
LAMA3	-4762
COL11A2	-5451
ITGB4	-5698
LAMB3	-6219

---

Signal regulatory protein family interactions

Signal regulatory protein family interactions

	1146
set	Signal regulatory protein family interactions
setSize	13
pANOVA	0.0273
s.dist	0.354
p.adjustANOVA	0.182

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIRPA	6479.5
SIRPB1	6479.5
SIRPG	6479.5
SKAP2	5688.0
PTK2	4968.0
PTPN11	3850.0
GRB2	2141.0
PTPN6	1564.0
SFTPA1	-205.5
SFTPA2	-205.5
SRC	-2498.0
CD47	-2524.0
PTK2B	-3472.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIRPA	6479.5
SIRPB1	6479.5
SIRPG	6479.5
SKAP2	5688.0
PTK2	4968.0
PTPN11	3850.0
GRB2	2141.0
PTPN6	1564.0
SFTPA1	-205.5
SFTPA2	-205.5
SRC	-2498.0
CD47	-2524.0
PTK2B	-3472.0

---

Chemokine receptors bind chemokines

Chemokine receptors bind chemokines

	183
set	Chemokine receptors bind chemokines
setSize	27
pANOVA	0.00157
s.dist	0.352
p.adjustANOVA	0.0436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CXCL16	4722.0
CXCL10	4691.0
CCL1	4584.0
CCL11	4584.0
CCL13	4584.0
CCL2	4584.0
CCL7	4584.0
CX3CL1	4584.0
ACKR3	4549.0
CXCL8	4436.0
CCL16	3658.0
CCR2	3598.5
CCR5	3598.5
CXCR5	3096.0
CXCR1	2511.5
CXCR2	2511.5
CCR7	2468.0
CXCL12	2384.0
ACKR4	2160.0
CXCR4	1951.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CXCL16	4722.0
CXCL10	4691.0
CCL1	4584.0
CCL11	4584.0
CCL13	4584.0
CCL2	4584.0
CCL7	4584.0
CX3CL1	4584.0
ACKR3	4549.0
CXCL8	4436.0
CCL16	3658.0
CCR2	3598.5
CCR5	3598.5
CXCR5	3096.0
CXCR1	2511.5
CXCR2	2511.5
CCR7	2468.0
CXCL12	2384.0
ACKR4	2160.0
CXCR4	1951.0
CX3CR1	-376.0
CXCL9	-895.0
ACKR2	-1268.0
CCRL2	-1432.0
CXCR3	-1767.0
CCL27	-2375.0
CCR1	-6467.0

---

Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation

	1012
set	Regulation of FOXO transcriptional activity by acetylation
setSize	10
pANOVA	0.0549
s.dist	-0.351
p.adjustANOVA	0.26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIRT1	-6462.0
FOXO4	-6451.0
KAT2B	-6314.0
EP300	-5571.0
TXN	-2909.0
TXNIP	-2753.0
SIRT3	-842.0
FOXO1	-534.0
CREBBP	595.0
FOXO3	5832.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIRT1	-6462.0
FOXO4	-6451.0
KAT2B	-6314.0
EP300	-5571.0
TXN	-2909.0
TXNIP	-2753.0
SIRT3	-842.0
FOXO1	-534.0
CREBBP	595.0
FOXO3	5832.5

---

Inflammasomes

Inflammasomes

	555
set	Inflammasomes
setSize	16
pANOVA	0.0159
s.dist	0.348
p.adjustANOVA	0.146

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	6552.0
PYCARD	5896.0
AIM2	5794.5
NFKB1	5585.0
HMOX1	5332.0
PANX1	5102.0
SUGT1	4282.0
RELA	3964.0
PSTPIP1	3544.0
P2RX7	2829.0
BCL2L1	1996.0
HSP90AB1	-1342.0
TXNIP	-2753.0
TXN	-2909.0
BCL2	-3247.0
NFKB2	-5863.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	6552.0
PYCARD	5896.0
AIM2	5794.5
NFKB1	5585.0
HMOX1	5332.0
PANX1	5102.0
SUGT1	4282.0
RELA	3964.0
PSTPIP1	3544.0
P2RX7	2829.0
BCL2L1	1996.0
HSP90AB1	-1342.0
TXNIP	-2753.0
TXN	-2909.0
BCL2	-3247.0
NFKB2	-5863.0

---

Degradation of the extracellular matrix

Degradation of the extracellular matrix

	287
set	Degradation of the extracellular matrix
setSize	107
pANOVA	9.05e-10
s.dist	0.343
p.adjustANOVA	4.35e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL16A1	6569
ADAM8	6526
FBN1	6514
COL12A1	6510
COL3A1	6495
CTSG	6491
COL9A1	6422
ADAMTS1	6402
CAPNS2	6375
MMP11	6348
MMP17	6324
MMP10	6309
MMP12	6309
COL6A1	6124
MMP15	6061
COL15A1	6019
COL9A3	5976
COL6A2	5897
TIMP2	5888
CAST	5878

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL16A1	6569.0
ADAM8	6526.0
FBN1	6514.0
COL12A1	6510.0
COL3A1	6495.0
CTSG	6491.0
COL9A1	6422.0
ADAMTS1	6402.0
CAPNS2	6375.0
MMP11	6348.0
MMP17	6324.0
MMP10	6309.0
MMP12	6309.0
COL6A1	6124.0
MMP15	6061.0
COL15A1	6019.0
COL9A3	5976.0
COL6A2	5897.0
TIMP2	5888.0
CAST	5878.0
COL5A2	5828.0
COL23A1	5824.0
COL4A2	5750.0
FN1	5695.0
COL5A1	5613.0
CAPN2	5453.0
COL8A1	5448.0
COL4A1	5416.0
HTRA1	5355.0
MMP1	5303.0
SPOCK3	5162.0
CAPN8	4964.0
COL4A4	4924.0
TPSAB1	4774.5
PSEN1	4766.0
CTRB1	4659.5
CTRB2	4659.5
ELN	4602.0
MMP20	4590.0
TLL1	4528.0
COL11A1	4427.0
CAPNS1	4424.0
ADAM10	4420.0
BMP1	4346.0
MMP14	4322.0
KLKB1	4313.0
ADAMTS5	4094.0
COL6A3	4052.0
LAMC1	4011.0
COL1A2	3999.0
MMP2	3894.0
MMP19	3874.0
CAPN1	3823.0
COL2A1	3754.0
MMP25	3746.0
MMP13	3610.0
COL25A1	3400.0
COL18A1	3012.0
CD44	2795.0
COL4A3	2590.0
LAMB1	2477.0
ADAMTS16	2455.0
CAPN7	2442.0
ADAM9	2318.0
CAPN5	2253.0
PRSS1	2078.0
PRSS2	2078.0
ADAM15	1811.0
CAPN10	1779.0
BSG	1537.0
ADAM17	1500.0
CTSB	1313.0
COL6A5	1224.0
COL8A2	939.0
CASP3	841.0
OPTC	347.0
CAPN9	-184.0
CAPN15	-311.0
TLL2	-530.0
COL13A1	-805.0
COL14A1	-867.0
CDH1	-1085.0
COL1A1	-1126.0
LAMC2	-1345.0
PHYKPL	-1595.0
NCSTN	-1630.0
SCUBE1	-2786.0
CTSL	-2893.0
CTSV	-2893.0
SCUBE3	-3257.0
COL5A3	-3320.0
FBN2	-3436.0
DCN	-3443.0
MMP24	-3687.0
ADAMTS9	-3719.0
FBN3	-4058.0
ADAMTS4	-4204.0
NID1	-4445.0
BCAN	-4737.0
LAMA3	-4762.0
COL11A2	-5451.0
LAMB3	-6219.0
CAPN3	-6272.0
CAPN6	-6609.0
MMP16	-6675.0
A2M	-6690.0
COL26A1	-6851.0

---

Defective Intrinsic Pathway for Apoptosis

Defective Intrinsic Pathway for Apoptosis

	272
set	Defective Intrinsic Pathway for Apoptosis
setSize	21
pANOVA	0.00679
s.dist	0.341
p.adjustANOVA	0.0899

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	6552.0
CAPNS2	6375.0
CAST	5878.0
FOXO3	5832.5
CAPN2	5453.0
CDK5R1	4706.0
CAPNS1	4424.0
C1QBP	4423.0
PRDX1	4265.0
TP53	4169.0
CAPN1	3823.0
LMNB1	3095.0
CDC25B	3069.0
YWHAE	1298.0
GOLGA2	504.0
LMNA	-1233.0
CDC25A	-1499.0
JUN	-2383.0
SOD2	-3634.0
BCL2L11	-4900.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	6552.0
CAPNS2	6375.0
CAST	5878.0
FOXO3	5832.5
CAPN2	5453.0
CDK5R1	4706.0
CAPNS1	4424.0
C1QBP	4423.0
PRDX1	4265.0
TP53	4169.0
CAPN1	3823.0
LMNB1	3095.0
CDC25B	3069.0
YWHAE	1298.0
GOLGA2	504.0
LMNA	-1233.0
CDC25A	-1499.0
JUN	-2383.0
SOD2	-3634.0
BCL2L11	-4900.0
PRDX2	-5569.0

---

Smooth Muscle Contraction

Smooth Muscle Contraction

	1235
set	Smooth Muscle Contraction
setSize	29
pANOVA	0.00147
s.dist	0.341
p.adjustANOVA	0.0436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TPM2	6246
ITGA1	6054
SORBS1	5942
LMOD1	5641
TPM4	5545
ANXA2	5368
ANXA1	5207
MYL12A	4934
VCL	4776
CACNA1H	4369
PXN	4365
TPM1	3908
MYL5	3713
TLN1	3550
ACTA2	3422
MYL9	3244
CALD1	2919
PAK1	2423
ACTG2	2391
MYL12B	1841

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TPM2	6246
ITGA1	6054
SORBS1	5942
LMOD1	5641
TPM4	5545
ANXA2	5368
ANXA1	5207
MYL12A	4934
VCL	4776
CACNA1H	4369
PXN	4365
TPM1	3908
MYL5	3713
TLN1	3550
ACTA2	3422
MYL9	3244
CALD1	2919
PAK1	2423
ACTG2	2391
MYL12B	1841
MYH11	650
TPM3	-100
ANXA6	-588
SORBS3	-1404
CALM1	-2399
PDE5A	-3900
GUCY1A2	-4491
ALDH2	-5709
CACNA1G	-6302

---

Synaptic adhesion-like molecules

Synaptic adhesion-like molecules

	1246
set	Synaptic adhesion-like molecules
setSize	20
pANOVA	0.0113
s.dist	-0.327
p.adjustANOVA	0.122

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LRFN4	-6657
GRIN2C	-6276
GRIA3	-6016
GRIN2B	-5881
DLG3	-5608
PTPRD	-5607
LRFN2	-5116
PTPRS	-4847
LRFN3	-4807
DLG4	-3440
FLOT2	-3287
RTN3	-2372
GRIN1	-828
PTPRF	-634
GRIA4	-595
LRFN1	1498
DLG1	2113
GRIA1	2677
FLOT1	2848
GRIN2A	5191

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LRFN4	-6657
GRIN2C	-6276
GRIA3	-6016
GRIN2B	-5881
DLG3	-5608
PTPRD	-5607
LRFN2	-5116
PTPRS	-4847
LRFN3	-4807
DLG4	-3440
FLOT2	-3287
RTN3	-2372
GRIN1	-828
PTPRF	-634
GRIA4	-595
LRFN1	1498
DLG1	2113
GRIA1	2677
FLOT1	2848
GRIN2A	5191

---

Classical antibody-mediated complement activation

Classical antibody-mediated complement activation

	199
set	Classical antibody-mediated complement activation
setSize	13
pANOVA	0.0413
s.dist	0.327
p.adjustANOVA	0.22

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C1R	6031.0
C1S	5276.0
IGLV4-3	4627.5
IGLV4-60	4627.5
IGLV4-69	4627.5
IGLV3-1	620.0
IGLV3-16	620.0
IGLV3-19	620.0
IGLV3-22	620.0
IGLV3-25	620.0
IGLV3-27	620.0
CRP	271.0
C1QA	-2781.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C1R	6031.0
C1S	5276.0
IGLV4-3	4627.5
IGLV4-60	4627.5
IGLV4-69	4627.5
IGLV3-1	620.0
IGLV3-16	620.0
IGLV3-19	620.0
IGLV3-22	620.0
IGLV3-25	620.0
IGLV3-27	620.0
CRP	271.0
C1QA	-2781.0

---

PIWI-interacting RNA (piRNA) biogenesis

PIWI-interacting RNA (piRNA) biogenesis

	830
set	PIWI-interacting RNA (piRNA) biogenesis
setSize	26
pANOVA	0.00394
s.dist	-0.327
p.adjustANOVA	0.0661

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FKBP6	-6923
TDRD9	-6670
TDRD1	-6666
PIWIL4	-6641
TDRD12	-6521
TDRKH	-6490
ASZ1	-6392
DDX4	-5676
PIWIL1	-5566
POLR2K	-5473
POLR2C	-4728
MOV10L1	-4339
POLR2E	-2797
TDRD6	-2540
PIWIL2	-2185
HSP90AA1	-1551
POLR2G	-1337
POLR2D	-700
POLR2B	745
POLR2F	834

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FKBP6	-6923
TDRD9	-6670
TDRD1	-6666
PIWIL4	-6641
TDRD12	-6521
TDRKH	-6490
ASZ1	-6392
DDX4	-5676
PIWIL1	-5566
POLR2K	-5473
POLR2C	-4728
MOV10L1	-4339
POLR2E	-2797
TDRD6	-2540
PIWIL2	-2185
HSP90AA1	-1551
POLR2G	-1337
POLR2D	-700
POLR2B	745
POLR2F	834
POLR2A	1103
POLR2H	2893
HENMT1	3522
POLR2J	3749
POLR2I	4159
POLR2L	4385

---

Processing of SMDT1

Processing of SMDT1

	899
set	Processing of SMDT1
setSize	12
pANOVA	0.0516
s.dist	0.325
p.adjustANOVA	0.251

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCUB	6170
MCU	5344
PHB2	4734
SPG7	4453
MICU2	4336
MICU1	3936
YME1L1	3752
PMPCA	1703
AFG3L2	-1338
PARL	-1660
MICU3	-2952
PMPCB	-4300

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCUB	6170
MCU	5344
PHB2	4734
SPG7	4453
MICU2	4336
MICU1	3936
YME1L1	3752
PMPCA	1703
AFG3L2	-1338
PARL	-1660
MICU3	-2952
PMPCB	-4300

---

Norepinephrine Neurotransmitter Release Cycle

Norepinephrine Neurotransmitter Release Cycle

	781
set	Norepinephrine Neurotransmitter Release Cycle
setSize	13
pANOVA	0.0431
s.dist	-0.324
p.adjustANOVA	0.226

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNAP25	-6420
MAOA	-6290
VAMP2	-5246
RAB3A	-5009
PPFIA1	-4707
TSPOAP1	-4541
PPFIA4	-3554
RIMS1	-3402
SLC18A2	-1739
STXBP1	-1109
SYT1	389
PPFIA2	5041
UNC13B	5894

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNAP25	-6420
MAOA	-6290
VAMP2	-5246
RAB3A	-5009
PPFIA1	-4707
TSPOAP1	-4541
PPFIA4	-3554
RIMS1	-3402
SLC18A2	-1739
STXBP1	-1109
SYT1	389
PPFIA2	5041
UNC13B	5894

---

Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

	854
set	Phase 0 - rapid depolarisation
setSize	24
pANOVA	0.00634
s.dist	-0.322
p.adjustANOVA	0.0854

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CACNB2	-6667
CACNA1C	-6630
SCN11A	-6012
FGF11	-5893
FGF14	-5780
CACNA2D2	-5287
SCN5A	-5188
SCN8A	-4846
CACNB1	-4703
SCN4B	-4343
RANGRF	-2918
CAMK2B	-2549
CALM1	-2399
SCN1A	-2215
SCN2B	-1964
SCN3A	-1266
FGF12	-1117
CAMK2G	-107
CACNG7	126
CACNG4	416

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CACNB2	-6667
CACNA1C	-6630
SCN11A	-6012
FGF11	-5893
FGF14	-5780
CACNA2D2	-5287
SCN5A	-5188
SCN8A	-4846
CACNB1	-4703
SCN4B	-4343
RANGRF	-2918
CAMK2B	-2549
CALM1	-2399
SCN1A	-2215
SCN2B	-1964
SCN3A	-1266
FGF12	-1117
CAMK2G	-107
CACNG7	126
CACNG4	416
SCN2A	950
CAMK2A	2726
SCN3B	3472
SCN9A	5905

---

Signaling by PDGF

Signaling by PDGF

	1208
set	Signaling by PDGF
setSize	49
pANOVA	0.000101
s.dist	0.321
p.adjustANOVA	0.00634

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	6568
THBS2	6562
PDGFA	6535
COL3A1	6495
PIK3R2	6424
COL9A1	6422
STAT5B	6289
COL6A1	6124
PIK3R1	6121
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL4A2	5750
COL5A1	5613
COL4A1	5416
SOS1	5406
COL4A4	4924
PTPN12	4177
COL6A3	4052
PTPN11	3850

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	6568
THBS2	6562
PDGFA	6535
COL3A1	6495
PIK3R2	6424
COL9A1	6422
STAT5B	6289
COL6A1	6124
PIK3R1	6121
COL9A3	5976
COL6A2	5897
COL5A2	5828
COL4A2	5750
COL5A1	5613
COL4A1	5416
SOS1	5406
COL4A4	4924
PTPN12	4177
COL6A3	4052
PTPN11	3850
COL2A1	3754
THBS3	3470
NCK1	3432
PLAT	2913
PLCG1	2818
STAT1	2690
COL4A3	2590
RASA1	2508
GRB2	2141
CRK	1992
THBS1	1489
COL6A5	1224
BCAR1	549
NCK2	191
THBS4	-583
PIK3CA	-1387
STAT6	-1397
CRKL	-1671
GRB7	-1803
SRC	-2498
RAPGEF1	-2716
COL5A3	-3320
KRAS	-3535
PDGFC	-4213
PDGFD	-4667
PIK3CB	-4714
HRAS	-4778
PDGFRB	-4831
STAT3	-6755

---

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

	1289
set	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
setSize	18
pANOVA	0.0187
s.dist	-0.32
p.adjustANOVA	0.156

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PLK3	-6636
CNOT4	-6389
PLK2	-6231
CNOT2	-5166
PLAGL1	-5065
CNOT10	-4028
CNOT6	-3702
CENPJ	-3644
CNOT11	-3341
RGCC	-3326
CNOT3	-2474
BTG2	-2291
CNOT6L	-1874
TNKS1BP1	-1867
CNOT7	2298
CNOT8	2363
TP53	4169
CNOT1	5187

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PLK3	-6636
CNOT4	-6389
PLK2	-6231
CNOT2	-5166
PLAGL1	-5065
CNOT10	-4028
CNOT6	-3702
CENPJ	-3644
CNOT11	-3341
RGCC	-3326
CNOT3	-2474
BTG2	-2291
CNOT6L	-1874
TNKS1BP1	-1867
CNOT7	2298
CNOT8	2363
TP53	4169
CNOT1	5187

---

Phase 2 - plateau phase

Phase 2 - plateau phase

	855
set	Phase 2 - plateau phase
setSize	10
pANOVA	0.0809
s.dist	-0.319
p.adjustANOVA	0.322

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CACNB2	-6667
CACNA1C	-6630
CACNA2D2	-5287
AKAP9	-5276
CACNB1	-4703
KCNQ1	-2566
CACNG7	126
CACNG4	416
KCNE3	2069
KCNE4	5256

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CACNB2	-6667
CACNA1C	-6630
CACNA2D2	-5287
AKAP9	-5276
CACNB1	-4703
KCNQ1	-2566
CACNG7	126
CACNG4	416
KCNE3	2069
KCNE4	5256

---

Scavenging by Class A Receptors

Scavenging by Class A Receptors

	1124
set	Scavenging by Class A Receptors
setSize	16
pANOVA	0.0308
s.dist	0.312
p.adjustANOVA	0.193

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL3A1	6495
COL4A2	5750
FTL	5522
COL4A1	5416
APOE	5117
FTH1	4564
COL1A2	3999
CALR	1901
MASP1	916
APOA1	645
MSR1	375
SCGB3A2	153
COL1A1	-1126
HSP90B1	-2206
COLEC12	-2338
SCARA5	-4327

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL3A1	6495
COL4A2	5750
FTL	5522
COL4A1	5416
APOE	5117
FTH1	4564
COL1A2	3999
CALR	1901
MASP1	916
APOA1	645
MSR1	375
SCGB3A2	153
COL1A1	-1126
HSP90B1	-2206
COLEC12	-2338
SCARA5	-4327

---

Cellular hexose transport

Cellular hexose transport

	173
set	Cellular hexose transport
setSize	15
pANOVA	0.0378
s.dist	-0.31
p.adjustANOVA	0.218

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC5A1	-6749
SLC2A8	-6710
SLC2A4	-6526
MFSD4B	-5902
SLC5A9	-5135
SLC2A6	-4637
SLC5A2	-4285
SLC50A1	-4226
FGF21	-3954
SLC2A1	-2433
SLC5A10	1545
SLC2A12	3415
SLC2A10	3547
SLC45A3	3860
SLC2A9	4225

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC5A1	-6749
SLC2A8	-6710
SLC2A4	-6526
MFSD4B	-5902
SLC5A9	-5135
SLC2A6	-4637
SLC5A2	-4285
SLC50A1	-4226
FGF21	-3954
SLC2A1	-2433
SLC5A10	1545
SLC2A12	3415
SLC2A10	3547
SLC45A3	3860
SLC2A9	4225

---

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models

	292
set	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models
setSize	19
pANOVA	0.0204
s.dist	0.307
p.adjustANOVA	0.159

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	6552.0
CAPNS2	6375.0
CAST	5878.0
FOXO3	5832.5
CAPN2	5453.0
CDK5R1	4706.0
CAPNS1	4424.0
PRDX1	4265.0
CAPN1	3823.0
LMNB1	3095.0
CDC25B	3069.0
YWHAE	1298.0
GOLGA2	504.0
LMNA	-1233.0
CDC25A	-1499.0
JUN	-2383.0
SOD2	-3634.0
BCL2L11	-4900.0
PRDX2	-5569.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	6552.0
CAPNS2	6375.0
CAST	5878.0
FOXO3	5832.5
CAPN2	5453.0
CDK5R1	4706.0
CAPNS1	4424.0
PRDX1	4265.0
CAPN1	3823.0
LMNB1	3095.0
CDC25B	3069.0
YWHAE	1298.0
GOLGA2	504.0
LMNA	-1233.0
CDC25A	-1499.0
JUN	-2383.0
SOD2	-3634.0
BCL2L11	-4900.0
PRDX2	-5569.0

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.2               GGally_2.1.2               
##  [3] ggplot2_3.4.0               beeswarm_0.4.0             
##  [5] gtools_3.9.4                tibble_3.1.8               
##  [7] echarts4r_0.4.4             dplyr_1.0.10               
##  [9] kableExtra_1.3.4            limma_3.54.0               
## [11] mitch_1.10.0                DESeq2_1.38.2              
## [13] SummarizedExperiment_1.28.0 Biobase_2.58.0             
## [15] MatrixGenerics_1.10.0       matrixStats_0.63.0         
## [17] GenomicRanges_1.50.2        GenomeInfoDb_1.34.6        
## [19] IRanges_2.32.0              S4Vectors_0.36.1           
## [21] BiocGenerics_0.44.0         gplots_3.1.3               
## [23] reshape2_1.4.4             
## 
## loaded via a namespace (and not attached):
##  [1] DBI_1.1.3              bitops_1.0-7           gridExtra_2.3         
##  [4] rlang_1.0.6            magrittr_2.0.3         compiler_4.3.1        
##  [7] RSQLite_2.2.20         systemfonts_1.0.4      png_0.1-8             
## [10] vctrs_0.5.1            rvest_1.0.3            stringr_1.5.0         
## [13] pkgconfig_2.0.3        crayon_1.5.2           fastmap_1.1.0         
## [16] XVector_0.38.0         ellipsis_0.3.2         caTools_1.18.2        
## [19] utf8_1.2.2             promises_1.2.0.1       rmarkdown_2.19        
## [22] bit_4.0.5              xfun_0.36              zlibbioc_1.44.0       
## [25] cachem_1.0.6           jsonlite_1.8.4         blob_1.2.3            
## [28] highr_0.10             later_1.3.0            DelayedArray_0.24.0   
## [31] reshape_0.8.9          BiocParallel_1.32.5    parallel_4.3.1        
## [34] R6_2.5.1               bslib_0.4.2            stringi_1.7.8         
## [37] RColorBrewer_1.1-3     jquerylib_0.1.4        Rcpp_1.0.9            
## [40] assertthat_0.2.1       knitr_1.41             httpuv_1.6.7          
## [43] Matrix_1.5-4.1         tidyselect_1.2.0       yaml_2.3.6            
## [46] rstudioapi_0.14        codetools_0.2-19       lattice_0.21-8        
## [49] plyr_1.8.8             withr_2.5.0            shiny_1.7.4           
## [52] KEGGREST_1.38.0        evaluate_0.19          xml2_1.3.3            
## [55] Biostrings_2.66.0      pillar_1.8.1           KernSmooth_2.23-20    
## [58] generics_0.1.3         RCurl_1.98-1.9         munsell_0.5.0         
## [61] scales_1.2.1           xtable_1.8-4           glue_1.6.2            
## [64] tools_4.3.1            webshot_0.5.4          annotate_1.76.0       
## [67] locfit_1.5-9.7         XML_3.99-0.13          grid_4.3.1            
## [70] AnnotationDbi_1.60.0   colorspace_2.0-3       GenomeInfoDbData_1.2.9
## [73] cli_3.6.0              fansi_1.0.3            viridisLite_0.4.1     
## [76] svglite_2.1.0          gtable_0.3.1           sass_0.4.4            
## [79] digest_0.6.31          geneplotter_1.76.0     htmlwidgets_1.6.1     
## [82] memoise_2.0.1          htmltools_0.5.4        lifecycle_1.0.3       
## [85] httr_1.4.4             mime_0.12              bit64_4.0.5           
## [88] MASS_7.3-59

END of report