Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-07-10
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## young old
## 0610009B22Rik -2.9385024 -6.1805927
## 0610009E02Rik 0.6410018 -1.6821055
## 0610009L18Rik -4.5856767 -3.1288917
## 0610010F05Rik 0.6483013 0.4402823
## 0610010K14Rik -8.7879236 -3.0864256
## 0610012G03Rik -8.7415080 -6.4223694Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 14877 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 7299 |
| num_profile_genes_not_in_sets | 7578 |
| profile_pearson_correl | 0.8374 |
| profile_spearman_correl | 0.80977 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ../ref/ReactomePathways_mouse.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2302 |
| num_genesets_excluded | 1023 |
| num_genesets_included | 1279 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 245 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.young | s.old | p.young | p.old |
|---|---|---|---|---|---|---|---|---|
| Termination-of-O-glycan-biosynthesis | 10 | 1.12e-03 | 8.70e-03 | 0.391 | 0.3910 | -0.005260 | 3.24e-02 | 9.77e-01 |
| Presynaptic-depolarization-and-calcium-channel-opening | 10 | 2.06e-03 | 1.45e-02 | 0.396 | 0.0225 | 0.395000 | 9.02e-01 | 3.06e-02 |
| Synaptic-adhesion-like-molecules | 15 | 1.73e-03 | 1.27e-02 | 0.285 | 0.2830 | -0.034700 | 5.76e-02 | 8.16e-01 |
| Interferon-alpha/beta-signaling | 40 | 1.39e-08 | 4.33e-07 | 0.363 | 0.0479 | 0.360000 | 6.01e-01 | 8.18e-05 |
| The-canonical-retinoid-cycle-in-rods-(twilight-vision) | 12 | 4.09e-04 | 3.79e-03 | 0.609 | 0.2450 | 0.557000 | 1.41e-01 | 8.31e-04 |
| N-glycan-antennae-elongation-in-the-medial/trans-Golgi | 20 | 2.41e-04 | 2.49e-03 | 0.355 | 0.3510 | 0.053100 | 6.62e-03 | 6.81e-01 |
| Chemokine-receptors-bind-chemokines | 20 | 2.50e-03 | 1.65e-02 | 0.303 | 0.2990 | 0.047400 | 2.05e-02 | 7.14e-01 |
| O-linked-glycosylation-of-mucins | 32 | 1.25e-05 | 2.29e-04 | 0.411 | 0.3860 | 0.141000 | 1.55e-04 | 1.69e-01 |
| HS-GAG-biosynthesis | 23 | 1.16e-04 | 1.41e-03 | 0.475 | 0.4340 | 0.192000 | 3.13e-04 | 1.12e-01 |
| WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2 | 13 | 5.29e-03 | 3.18e-02 | 0.492 | 0.4460 | 0.206000 | 5.33e-03 | 1.98e-01 |
| HS-GAG-degradation | 18 | 4.70e-04 | 4.23e-03 | 0.526 | 0.4710 | 0.234000 | 5.46e-04 | 8.52e-02 |
| FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes | 23 | 9.53e-03 | 4.97e-02 | 0.162 | 0.0955 | -0.131000 | 4.28e-01 | 2.77e-01 |
| Sialic-acid-metabolism | 26 | 3.27e-03 | 2.07e-02 | 0.239 | 0.2380 | 0.016800 | 3.55e-02 | 8.82e-01 |
| Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity | 23 | 6.01e-03 | 3.47e-02 | 0.250 | 0.2480 | 0.028000 | 3.95e-02 | 8.17e-01 |
| Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes | 29 | 3.25e-03 | 2.07e-02 | 0.225 | -0.0147 | -0.225000 | 8.91e-01 | 3.62e-02 |
| Triglyceride-catabolism | 15 | 9.29e-06 | 1.75e-04 | 0.868 | -0.5030 | -0.708000 | 7.41e-04 | 2.07e-06 |
| Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A | 48 | 2.72e-05 | 4.30e-04 | 0.339 | -0.3150 | -0.127000 | 1.64e-04 | 1.29e-01 |
| p53-Independent-DNA-Damage-Response | 48 | 2.72e-05 | 4.30e-04 | 0.339 | -0.3150 | -0.127000 | 1.64e-04 | 1.29e-01 |
| p53-Independent-G1/S-DNA-damage-checkpoint | 48 | 2.72e-05 | 4.30e-04 | 0.339 | -0.3150 | -0.127000 | 1.64e-04 | 1.29e-01 |
| Assembly-of-the-pre-replicative-complex | 64 | 6.67e-05 | 9.17e-04 | 0.186 | -0.1860 | -0.000335 | 9.99e-03 | 9.96e-01 |
| Regulation-of-ornithine-decarboxylase-(ODC) | 46 | 3.97e-05 | 5.96e-04 | 0.347 | -0.3200 | -0.135000 | 1.73e-04 | 1.13e-01 |
| Autodegradation-of-the-E3-ubiquitin-ligase-COP1 | 47 | 7.41e-05 | 9.77e-04 | 0.315 | -0.2950 | -0.110000 | 4.69e-04 | 1.92e-01 |
| Heparan-sulfate/heparin-(HS-GAG)-metabolism | 42 | 1.75e-07 | 4.23e-06 | 0.551 | 0.4710 | 0.287000 | 1.31e-07 | 1.31e-03 |
| Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT) | 30 | 7.64e-03 | 4.20e-02 | 0.229 | 0.2250 | 0.041200 | 3.28e-02 | 6.96e-01 |
| Post-NMDA-receptor-activation-events | 50 | 1.31e-03 | 9.94e-03 | 0.136 | 0.1220 | -0.060900 | 1.36e-01 | 4.56e-01 |
| RAB-geranylgeranylation | 51 | 1.00e-03 | 8.01e-03 | 0.148 | 0.1420 | -0.041000 | 8.01e-02 | 6.13e-01 |
| DNA-Replication-Pre-Initiation | 80 | 2.28e-05 | 3.89e-04 | 0.146 | -0.1390 | 0.042600 | 3.15e-02 | 5.10e-01 |
| Stabilization-of-p53 | 51 | 7.50e-05 | 9.79e-04 | 0.291 | -0.2760 | -0.094000 | 6.62e-04 | 2.46e-01 |
| Smooth-Muscle-Contraction | 31 | 9.21e-03 | 4.83e-02 | 0.213 | 0.0314 | 0.211000 | 7.62e-01 | 4.21e-02 |
| Activation-of-the-pre-replicative-complex | 32 | 5.28e-03 | 3.18e-02 | 0.247 | 0.0599 | 0.239000 | 5.58e-01 | 1.91e-02 |
| Ubiquitin-dependent-degradation-of-Cyclin-D | 48 | 1.72e-04 | 1.90e-03 | 0.288 | -0.2720 | -0.093600 | 1.11e-03 | 2.62e-01 |
| Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation | 46 | 6.86e-05 | 9.33e-04 | 0.343 | -0.3150 | -0.137000 | 2.24e-04 | 1.08e-01 |
| Protein-ubiquitination | 62 | 3.31e-04 | 3.24e-03 | 0.156 | 0.0222 | -0.154000 | 7.62e-01 | 3.60e-02 |
| TNFs-bind-their-physiological-receptors | 12 | 6.81e-03 | 3.84e-02 | 0.609 | 0.3340 | 0.509000 | 4.52e-02 | 2.25e-03 |
| AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA | 50 | 9.96e-05 | 1.22e-03 | 0.308 | -0.2860 | -0.113000 | 4.63e-04 | 1.68e-01 |
| Orc1-removal-from-chromatin | 66 | 9.92e-05 | 1.22e-03 | 0.203 | -0.2010 | -0.027600 | 4.76e-03 | 6.98e-01 |
| CDT1-association-with-the-CDC6:ORC:origin-complex | 55 | 2.89e-05 | 4.51e-04 | 0.320 | -0.2960 | -0.123000 | 1.49e-04 | 1.16e-01 |
| Cross-presentation-of-soluble-exogenous-antigens-(endosomes) | 44 | 5.19e-04 | 4.61e-03 | 0.289 | -0.2710 | -0.100000 | 1.86e-03 | 2.50e-01 |
| Intra-Golgi-traffic | 41 | 5.73e-03 | 3.32e-02 | 0.168 | 0.1680 | -0.002910 | 6.30e-02 | 9.74e-01 |
| Regulation-of-Apoptosis | 49 | 1.45e-05 | 2.61e-04 | 0.390 | -0.3470 | -0.177000 | 2.60e-05 | 3.17e-02 |
| Vpu-mediated-degradation-of-CD4 | 48 | 5.10e-05 | 7.25e-04 | 0.358 | -0.3230 | -0.154000 | 1.09e-04 | 6.44e-02 |
| Degradation-of-AXIN | 51 | 2.92e-04 | 2.94e-03 | 0.276 | -0.2590 | -0.093300 | 1.36e-03 | 2.49e-01 |
| Vif-mediated-degradation-of-APOBEC3G | 48 | 3.71e-05 | 5.65e-04 | 0.376 | -0.3350 | -0.170000 | 5.91e-05 | 4.14e-02 |
| Class-I-peroxisomal-membrane-protein-import | 19 | 1.70e-04 | 1.90e-03 | 0.660 | -0.3770 | -0.542000 | 4.41e-03 | 4.30e-05 |
| Negative-regulation-of-NOTCH4-signaling | 51 | 1.22e-04 | 1.47e-03 | 0.318 | -0.2910 | -0.128000 | 3.29e-04 | 1.14e-01 |
| SCF-beta-TrCP-mediated-degradation-of-Emi1 | 51 | 8.26e-05 | 1.06e-03 | 0.335 | -0.3030 | -0.142000 | 1.81e-04 | 8.02e-02 |
| DARPP-32-events | 22 | 7.90e-03 | 4.31e-02 | 0.395 | -0.1870 | -0.348000 | 1.29e-01 | 4.75e-03 |
| Regulation-of-RUNX3-expression-and-activity | 52 | 2.51e-03 | 1.65e-02 | 0.177 | -0.1760 | -0.016500 | 2.83e-02 | 8.37e-01 |
| Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein | 69 | 6.68e-04 | 5.77e-03 | 0.143 | 0.1420 | -0.017200 | 4.15e-02 | 8.04e-01 |
| The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint | 55 | 1.73e-03 | 1.27e-02 | 0.179 | -0.1780 | -0.019000 | 2.23e-02 | 8.08e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.young | s.old | p.young | p.old |
|---|---|---|---|---|---|---|---|---|
| Termination-of-O-glycan-biosynthesis | 10 | 1.12e-03 | 8.70e-03 | 0.3910 | 0.3910 | -0.005260 | 3.24e-02 | 9.77e-01 |
| Presynaptic-depolarization-and-calcium-channel-opening | 10 | 2.06e-03 | 1.45e-02 | 0.3960 | 0.0225 | 0.395000 | 9.02e-01 | 3.06e-02 |
| Synaptic-adhesion-like-molecules | 15 | 1.73e-03 | 1.27e-02 | 0.2850 | 0.2830 | -0.034700 | 5.76e-02 | 8.16e-01 |
| Interferon-alpha/beta-signaling | 40 | 1.39e-08 | 4.33e-07 | 0.3630 | 0.0479 | 0.360000 | 6.01e-01 | 8.18e-05 |
| The-canonical-retinoid-cycle-in-rods-(twilight-vision) | 12 | 4.09e-04 | 3.79e-03 | 0.6090 | 0.2450 | 0.557000 | 1.41e-01 | 8.31e-04 |
| N-glycan-antennae-elongation-in-the-medial/trans-Golgi | 20 | 2.41e-04 | 2.49e-03 | 0.3550 | 0.3510 | 0.053100 | 6.62e-03 | 6.81e-01 |
| Chemokine-receptors-bind-chemokines | 20 | 2.50e-03 | 1.65e-02 | 0.3030 | 0.2990 | 0.047400 | 2.05e-02 | 7.14e-01 |
| O-linked-glycosylation-of-mucins | 32 | 1.25e-05 | 2.29e-04 | 0.4110 | 0.3860 | 0.141000 | 1.55e-04 | 1.69e-01 |
| HS-GAG-biosynthesis | 23 | 1.16e-04 | 1.41e-03 | 0.4750 | 0.4340 | 0.192000 | 3.13e-04 | 1.12e-01 |
| WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2 | 13 | 5.29e-03 | 3.18e-02 | 0.4920 | 0.4460 | 0.206000 | 5.33e-03 | 1.98e-01 |
| HS-GAG-degradation | 18 | 4.70e-04 | 4.23e-03 | 0.5260 | 0.4710 | 0.234000 | 5.46e-04 | 8.52e-02 |
| FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes | 23 | 9.53e-03 | 4.97e-02 | 0.1620 | 0.0955 | -0.131000 | 4.28e-01 | 2.77e-01 |
| Sialic-acid-metabolism | 26 | 3.27e-03 | 2.07e-02 | 0.2390 | 0.2380 | 0.016800 | 3.55e-02 | 8.82e-01 |
| Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity | 23 | 6.01e-03 | 3.47e-02 | 0.2500 | 0.2480 | 0.028000 | 3.95e-02 | 8.17e-01 |
| Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes | 29 | 3.25e-03 | 2.07e-02 | 0.2250 | -0.0147 | -0.225000 | 8.91e-01 | 3.62e-02 |
| Triglyceride-catabolism | 15 | 9.29e-06 | 1.75e-04 | 0.8680 | -0.5030 | -0.708000 | 7.41e-04 | 2.07e-06 |
| Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A | 48 | 2.72e-05 | 4.30e-04 | 0.3390 | -0.3150 | -0.127000 | 1.64e-04 | 1.29e-01 |
| p53-Independent-DNA-Damage-Response | 48 | 2.72e-05 | 4.30e-04 | 0.3390 | -0.3150 | -0.127000 | 1.64e-04 | 1.29e-01 |
| p53-Independent-G1/S-DNA-damage-checkpoint | 48 | 2.72e-05 | 4.30e-04 | 0.3390 | -0.3150 | -0.127000 | 1.64e-04 | 1.29e-01 |
| Assembly-of-the-pre-replicative-complex | 64 | 6.67e-05 | 9.17e-04 | 0.1860 | -0.1860 | -0.000335 | 9.99e-03 | 9.96e-01 |
| Regulation-of-ornithine-decarboxylase-(ODC) | 46 | 3.97e-05 | 5.96e-04 | 0.3470 | -0.3200 | -0.135000 | 1.73e-04 | 1.13e-01 |
| Autodegradation-of-the-E3-ubiquitin-ligase-COP1 | 47 | 7.41e-05 | 9.77e-04 | 0.3150 | -0.2950 | -0.110000 | 4.69e-04 | 1.92e-01 |
| Heparan-sulfate/heparin-(HS-GAG)-metabolism | 42 | 1.75e-07 | 4.23e-06 | 0.5510 | 0.4710 | 0.287000 | 1.31e-07 | 1.31e-03 |
| Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT) | 30 | 7.64e-03 | 4.20e-02 | 0.2290 | 0.2250 | 0.041200 | 3.28e-02 | 6.96e-01 |
| Post-NMDA-receptor-activation-events | 50 | 1.31e-03 | 9.94e-03 | 0.1360 | 0.1220 | -0.060900 | 1.36e-01 | 4.56e-01 |
| RAB-geranylgeranylation | 51 | 1.00e-03 | 8.01e-03 | 0.1480 | 0.1420 | -0.041000 | 8.01e-02 | 6.13e-01 |
| DNA-Replication-Pre-Initiation | 80 | 2.28e-05 | 3.89e-04 | 0.1460 | -0.1390 | 0.042600 | 3.15e-02 | 5.10e-01 |
| Stabilization-of-p53 | 51 | 7.50e-05 | 9.79e-04 | 0.2910 | -0.2760 | -0.094000 | 6.62e-04 | 2.46e-01 |
| Smooth-Muscle-Contraction | 31 | 9.21e-03 | 4.83e-02 | 0.2130 | 0.0314 | 0.211000 | 7.62e-01 | 4.21e-02 |
| Activation-of-the-pre-replicative-complex | 32 | 5.28e-03 | 3.18e-02 | 0.2470 | 0.0599 | 0.239000 | 5.58e-01 | 1.91e-02 |
| Ubiquitin-dependent-degradation-of-Cyclin-D | 48 | 1.72e-04 | 1.90e-03 | 0.2880 | -0.2720 | -0.093600 | 1.11e-03 | 2.62e-01 |
| Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation | 46 | 6.86e-05 | 9.33e-04 | 0.3430 | -0.3150 | -0.137000 | 2.24e-04 | 1.08e-01 |
| Protein-ubiquitination | 62 | 3.31e-04 | 3.24e-03 | 0.1560 | 0.0222 | -0.154000 | 7.62e-01 | 3.60e-02 |
| TNFs-bind-their-physiological-receptors | 12 | 6.81e-03 | 3.84e-02 | 0.6090 | 0.3340 | 0.509000 | 4.52e-02 | 2.25e-03 |
| AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA | 50 | 9.96e-05 | 1.22e-03 | 0.3080 | -0.2860 | -0.113000 | 4.63e-04 | 1.68e-01 |
| Orc1-removal-from-chromatin | 66 | 9.92e-05 | 1.22e-03 | 0.2030 | -0.2010 | -0.027600 | 4.76e-03 | 6.98e-01 |
| CDT1-association-with-the-CDC6:ORC:origin-complex | 55 | 2.89e-05 | 4.51e-04 | 0.3200 | -0.2960 | -0.123000 | 1.49e-04 | 1.16e-01 |
| Cross-presentation-of-soluble-exogenous-antigens-(endosomes) | 44 | 5.19e-04 | 4.61e-03 | 0.2890 | -0.2710 | -0.100000 | 1.86e-03 | 2.50e-01 |
| Intra-Golgi-traffic | 41 | 5.73e-03 | 3.32e-02 | 0.1680 | 0.1680 | -0.002910 | 6.30e-02 | 9.74e-01 |
| Regulation-of-Apoptosis | 49 | 1.45e-05 | 2.61e-04 | 0.3900 | -0.3470 | -0.177000 | 2.60e-05 | 3.17e-02 |
| Vpu-mediated-degradation-of-CD4 | 48 | 5.10e-05 | 7.25e-04 | 0.3580 | -0.3230 | -0.154000 | 1.09e-04 | 6.44e-02 |
| Degradation-of-AXIN | 51 | 2.92e-04 | 2.94e-03 | 0.2760 | -0.2590 | -0.093300 | 1.36e-03 | 2.49e-01 |
| Vif-mediated-degradation-of-APOBEC3G | 48 | 3.71e-05 | 5.65e-04 | 0.3760 | -0.3350 | -0.170000 | 5.91e-05 | 4.14e-02 |
| Class-I-peroxisomal-membrane-protein-import | 19 | 1.70e-04 | 1.90e-03 | 0.6600 | -0.3770 | -0.542000 | 4.41e-03 | 4.30e-05 |
| Negative-regulation-of-NOTCH4-signaling | 51 | 1.22e-04 | 1.47e-03 | 0.3180 | -0.2910 | -0.128000 | 3.29e-04 | 1.14e-01 |
| SCF-beta-TrCP-mediated-degradation-of-Emi1 | 51 | 8.26e-05 | 1.06e-03 | 0.3350 | -0.3030 | -0.142000 | 1.81e-04 | 8.02e-02 |
| DARPP-32-events | 22 | 7.90e-03 | 4.31e-02 | 0.3950 | -0.1870 | -0.348000 | 1.29e-01 | 4.75e-03 |
| Regulation-of-RUNX3-expression-and-activity | 52 | 2.51e-03 | 1.65e-02 | 0.1770 | -0.1760 | -0.016500 | 2.83e-02 | 8.37e-01 |
| Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein | 69 | 6.68e-04 | 5.77e-03 | 0.1430 | 0.1420 | -0.017200 | 4.15e-02 | 8.04e-01 |
| The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint | 55 | 1.73e-03 | 1.27e-02 | 0.1790 | -0.1780 | -0.019000 | 2.23e-02 | 8.08e-01 |
| Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer | 43 | 1.40e-03 | 1.06e-02 | 0.2790 | 0.2600 | 0.102000 | 3.18e-03 | 2.50e-01 |
| MET-promotes-cell-motility | 27 | 4.01e-05 | 5.96e-04 | 0.5880 | 0.4880 | 0.329000 | 1.16e-05 | 3.08e-03 |
| FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis | 51 | 1.71e-04 | 1.90e-03 | 0.3180 | -0.2890 | -0.132000 | 3.60e-04 | 1.04e-01 |
| Degradation-of-the-extracellular-matrix | 74 | 5.69e-11 | 2.49e-09 | 0.5310 | 0.4450 | 0.289000 | 3.56e-11 | 1.80e-05 |
| Regulation-of-RUNX2-expression-and-activity | 66 | 1.43e-04 | 1.68e-03 | 0.2460 | -0.2330 | -0.077900 | 1.08e-03 | 2.74e-01 |
| Metabolism-of-polyamines | 53 | 1.43e-03 | 1.08e-02 | 0.2210 | -0.2130 | -0.058600 | 7.45e-03 | 4.61e-01 |
| RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs | 64 | 3.53e-04 | 3.37e-03 | 0.2300 | -0.2190 | -0.068000 | 2.40e-03 | 3.47e-01 |
| ER-Phagosome-pathway | 73 | 5.67e-04 | 4.97e-03 | 0.1700 | -0.1690 | -0.019800 | 1.25e-02 | 7.70e-01 |
| p53-Dependent-G1-DNA-Damage-Response | 59 | 9.94e-04 | 8.00e-03 | 0.2190 | -0.2100 | -0.061400 | 5.29e-03 | 4.15e-01 |
| p53-Dependent-G1/S-DNA-damage-checkpoint | 59 | 9.94e-04 | 8.00e-03 | 0.2190 | -0.2100 | -0.061400 | 5.29e-03 | 4.15e-01 |
| Hh-mutants-abrogate-ligand-secretion | 53 | 3.99e-04 | 3.74e-03 | 0.2920 | -0.2670 | -0.119000 | 7.77e-04 | 1.34e-01 |
| Transport-to-the-Golgi-and-subsequent-modification | 145 | 2.99e-06 | 5.79e-05 | 0.1160 | 0.1100 | -0.037900 | 2.23e-02 | 4.32e-01 |
| Synthesis-of-substrates-in-N-glycan-biosythesis | 56 | 3.48e-03 | 2.19e-02 | 0.1720 | 0.1710 | 0.023000 | 2.73e-02 | 7.66e-01 |
| COPI-dependent-Golgi-to-ER-retrograde-traffic | 74 | 1.18e-06 | 2.61e-05 | 0.3620 | 0.3190 | 0.171000 | 2.15e-06 | 1.09e-02 |
| Intra-Golgi-and-retrograde-Golgi-to-ER-traffic | 168 | 7.64e-10 | 2.71e-08 | 0.2450 | 0.2300 | 0.083100 | 2.68e-07 | 6.36e-02 |
| Peptide-ligand-binding-receptors | 57 | 5.45e-03 | 3.23e-02 | 0.1370 | 0.1360 | -0.010600 | 7.50e-02 | 8.90e-01 |
| DNA-strand-elongation | 31 | 8.91e-03 | 4.73e-02 | 0.3050 | 0.1300 | 0.276000 | 2.12e-01 | 7.85e-03 |
| Regulation-of-RAS-by-GAPs | 63 | 1.17e-03 | 9.04e-03 | 0.1980 | -0.1930 | -0.047000 | 8.17e-03 | 5.19e-01 |
| COPII-mediated-vesicle-transport | 58 | 7.93e-03 | 4.31e-02 | 0.1100 | 0.0438 | -0.101000 | 5.65e-01 | 1.85e-01 |
| Peroxisomal-lipid-metabolism | 22 | 3.71e-05 | 5.65e-04 | 0.6870 | -0.4090 | -0.552000 | 9.02e-04 | 7.27e-06 |
| Activation-of-NF-kappaB-in-B-cells | 62 | 1.68e-03 | 1.25e-02 | 0.1960 | -0.1900 | -0.047500 | 9.72e-03 | 5.18e-01 |
| NIK-->noncanonical-NF-kB-signaling | 55 | 5.97e-04 | 5.19e-03 | 0.2800 | -0.2560 | -0.115000 | 1.03e-03 | 1.41e-01 |
| G1/S-DNA-Damage-Checkpoints | 61 | 1.77e-03 | 1.29e-02 | 0.2050 | -0.1970 | -0.056600 | 7.84e-03 | 4.45e-01 |
| Hh-mutants-that-don't-undergo-autocatalytic-processing-are-degraded-by-ERAD | 51 | 4.47e-04 | 4.11e-03 | 0.3170 | -0.2830 | -0.143000 | 4.82e-04 | 7.68e-02 |
| Regulation-of-PTEN-gene-transcription | 59 | 4.45e-03 | 2.74e-02 | 0.1740 | -0.0331 | -0.171000 | 6.61e-01 | 2.33e-02 |
| Degradation-of-GLI1-by-the-proteasome | 55 | 1.82e-04 | 1.99e-03 | 0.3310 | -0.2920 | -0.155000 | 1.78e-04 | 4.67e-02 |
| Dectin-1-mediated-noncanonical-NF-kB-signaling | 56 | 1.08e-03 | 8.56e-03 | 0.2610 | -0.2400 | -0.103000 | 1.94e-03 | 1.84e-01 |
| Asparagine-N-linked-glycosylation | 251 | 7.80e-09 | 2.56e-07 | 0.1140 | 0.1110 | -0.024500 | 2.51e-03 | 5.05e-01 |
| Degradation-of-DVL | 52 | 2.99e-04 | 2.99e-03 | 0.3330 | -0.2930 | -0.158000 | 2.56e-04 | 4.90e-02 |
| SCF(Skp2)-mediated-degradation-of-p27/p21 | 57 | 2.76e-03 | 1.79e-02 | 0.2180 | -0.2060 | -0.071200 | 7.12e-03 | 3.53e-01 |
| HCMV-Infection | 80 | 2.50e-03 | 1.65e-02 | 0.1150 | 0.1130 | -0.021700 | 8.02e-02 | 7.37e-01 |
| MET-activates-PTK2-signaling | 17 | 1.25e-04 | 1.50e-03 | 0.7490 | 0.5930 | 0.458000 | 2.33e-05 | 1.08e-03 |
| G2/M-Checkpoints | 125 | 1.43e-04 | 1.68e-03 | 0.0952 | -0.0653 | 0.069200 | 2.08e-01 | 1.82e-01 |
| UCH-proteinases | 80 | 9.06e-04 | 7.42e-03 | 0.1780 | -0.1730 | -0.040700 | 7.49e-03 | 5.30e-01 |
| Hedgehog-ligand-biogenesis | 56 | 2.45e-03 | 1.64e-02 | 0.2370 | -0.2200 | -0.087700 | 4.49e-03 | 2.56e-01 |
| Peroxisomal-protein-import | 53 | 2.97e-12 | 1.52e-10 | 0.7290 | -0.4460 | -0.577000 | 1.95e-08 | 3.55e-13 |
| ABC-transporter-disorders | 66 | 7.84e-05 | 1.01e-03 | 0.3220 | -0.2830 | -0.155000 | 7.23e-05 | 2.99e-02 |
| Glutamate-Neurotransmitter-Release-Cycle | 18 | 7.24e-03 | 4.01e-02 | 0.5110 | 0.2920 | 0.420000 | 3.19e-02 | 2.05e-03 |
| Senescence-Associated-Secretory-Phenotype-(SASP) | 45 | 5.00e-03 | 3.03e-02 | 0.2720 | 0.2450 | 0.118000 | 4.48e-03 | 1.71e-01 |
| Regulation-of-PTEN-stability-and-activity | 65 | 3.58e-04 | 3.39e-03 | 0.2830 | -0.2530 | -0.127000 | 4.21e-04 | 7.71e-02 |
| Signaling-by-TGF-beta-Receptor-Complex | 71 | 2.37e-03 | 1.60e-02 | 0.1940 | 0.1840 | 0.060200 | 7.28e-03 | 3.81e-01 |
| Defective-CFTR-causes-cystic-fibrosis | 55 | 4.89e-04 | 4.38e-03 | 0.3200 | -0.2800 | -0.156000 | 3.33e-04 | 4.53e-02 |
| Degradation-of-GLI2-by-the-proteasome | 55 | 1.02e-03 | 8.12e-03 | 0.2960 | -0.2610 | -0.139000 | 8.06e-04 | 7.55e-02 |
| Defective-B4GALT7-causes-EDS,-progeroid-type | 16 | 5.72e-03 | 3.32e-02 | 0.5710 | 0.4600 | 0.338000 | 1.44e-03 | 1.94e-02 |
| O-linked-glycosylation | 74 | 6.33e-07 | 1.45e-05 | 0.4120 | 0.3460 | 0.224000 | 2.66e-07 | 8.88e-04 |
| Crosslinking-of-collagen-fibrils | 10 | 8.72e-04 | 7.29e-03 | 0.8870 | 0.6850 | 0.563000 | 1.75e-04 | 2.06e-03 |
| Carnitine-metabolism | 12 | 1.61e-03 | 1.21e-02 | 0.7640 | -0.4760 | -0.598000 | 4.31e-03 | 3.37e-04 |
| GLI3-is-processed-to-GLI3R-by-the-proteasome | 55 | 9.59e-04 | 7.81e-03 | 0.3000 | -0.2640 | -0.143000 | 7.06e-04 | 6.74e-02 |
| Golgi-to-ER-retrograde-transport | 105 | 1.65e-06 | 3.35e-05 | 0.3020 | 0.2660 | 0.144000 | 2.62e-06 | 1.07e-02 |
| Interleukin-4-and-Interleukin-13-signaling | 76 | 5.17e-05 | 7.26e-04 | 0.3100 | 0.2710 | 0.151000 | 4.48e-05 | 2.30e-02 |
| A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis | 21 | 1.81e-03 | 1.31e-02 | 0.5500 | 0.4440 | 0.324000 | 4.28e-04 | 1.01e-02 |
| Triglyceride-metabolism | 22 | 6.65e-05 | 9.17e-04 | 0.6840 | -0.4200 | -0.539000 | 6.50e-04 | 1.19e-05 |
| Synthesis-of-PIPs-at-the-plasma-membrane | 51 | 3.76e-03 | 2.34e-02 | 0.2720 | 0.2420 | 0.124000 | 2.84e-03 | 1.25e-01 |
| Signaling-by-MET | 60 | 2.20e-04 | 2.31e-03 | 0.3340 | 0.2870 | 0.170000 | 1.19e-04 | 2.28e-02 |
| Laminin-interactions | 22 | 5.04e-05 | 7.24e-04 | 0.6980 | 0.5480 | 0.433000 | 8.72e-06 | 4.33e-04 |
| ER-to-Golgi-Anterograde-Transport | 120 | 2.34e-03 | 1.60e-02 | 0.0803 | 0.0551 | -0.058500 | 2.98e-01 | 2.69e-01 |
| Formation-of-Incision-Complex-in-GG-NER | 43 | 6.52e-03 | 3.71e-02 | 0.2960 | -0.1450 | -0.258000 | 9.92e-02 | 3.44e-03 |
| Activation-of-SMO | 15 | 6.16e-03 | 3.52e-02 | 0.5970 | 0.3620 | 0.474000 | 1.52e-02 | 1.47e-03 |
| Signaling-by-the-B-Cell-Receptor-(BCR) | 103 | 2.88e-03 | 1.86e-02 | 0.1240 | -0.1240 | -0.011700 | 3.00e-02 | 8.37e-01 |
| Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha | 60 | 4.60e-04 | 4.17e-03 | 0.3230 | -0.2760 | -0.167000 | 2.17e-04 | 2.57e-02 |
| Defective-B3GAT3-causes-JDSSDHD | 16 | 5.53e-03 | 3.25e-02 | 0.5860 | 0.4640 | 0.357000 | 1.30e-03 | 1.34e-02 |
| Potassium-Channels | 56 | 2.20e-03 | 1.51e-02 | 0.2890 | -0.2510 | -0.144000 | 1.17e-03 | 6.24e-02 |
| Collagen-degradation | 26 | 1.57e-04 | 1.78e-03 | 0.6000 | 0.4730 | 0.368000 | 2.93e-05 | 1.17e-03 |
| Defective-B3GALT6-causes-EDSP2-and-SEMDJL1 | 16 | 2.19e-03 | 1.51e-02 | 0.6440 | 0.5050 | 0.400000 | 4.69e-04 | 5.66e-03 |
| Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements | 83 | 3.05e-03 | 1.95e-02 | 0.1980 | -0.1820 | -0.078200 | 4.26e-03 | 2.19e-01 |
| Signaling-by-TGF-beta-family-members | 88 | 1.19e-03 | 9.19e-03 | 0.2220 | 0.1990 | 0.098100 | 1.25e-03 | 1.12e-01 |
| p130Cas-linkage-to-MAPK-signaling-for-integrins | 14 | 1.95e-03 | 1.38e-02 | 0.7040 | 0.5450 | 0.446000 | 4.11e-04 | 3.88e-03 |
| APC/C:Cdc20-mediated-degradation-of-Securin | 62 | 6.76e-03 | 3.83e-02 | 0.2360 | -0.2090 | -0.109000 | 4.50e-03 | 1.37e-01 |
| Cellular-response-to-hypoxia | 68 | 8.97e-04 | 7.40e-03 | 0.2900 | -0.2480 | -0.150000 | 4.10e-04 | 3.31e-02 |
| Interferon-gamma-signaling | 58 | 7.00e-03 | 3.91e-02 | 0.2500 | 0.1210 | 0.219000 | 1.12e-01 | 3.95e-03 |
| Downstream-TCR-signaling | 77 | 5.45e-03 | 3.23e-02 | 0.2040 | -0.1850 | -0.087400 | 5.10e-03 | 1.85e-01 |
| Signaling-by-NOTCH4 | 78 | 4.53e-03 | 2.78e-02 | 0.2100 | -0.1890 | -0.092300 | 3.95e-03 | 1.59e-01 |
| FCERI-mediated-NF-kB-activation | 73 | 1.92e-03 | 1.38e-02 | 0.2570 | -0.2230 | -0.129000 | 1.01e-03 | 5.75e-02 |
| ABC-family-proteins-mediated-transport | 89 | 1.75e-05 | 3.10e-04 | 0.3340 | -0.2790 | -0.185000 | 5.62e-06 | 2.63e-03 |
| tRNA-processing-in-the-mitochondrion | 18 | 3.43e-09 | 1.18e-07 | 1.1300 | -0.7500 | -0.842000 | 3.52e-08 | 6.26e-10 |
| Glycosaminoglycan-metabolism | 99 | 1.18e-12 | 6.29e-11 | 0.5510 | 0.4310 | 0.343000 | 1.26e-13 | 3.57e-09 |
| Prolactin-receptor-signaling | 11 | 5.73e-03 | 3.32e-02 | 0.7310 | -0.4720 | -0.559000 | 6.73e-03 | 1.34e-03 |
| Membrane-Trafficking | 530 | 1.50e-08 | 4.57e-07 | 0.1050 | 0.1030 | 0.017500 | 5.05e-05 | 4.93e-01 |
| Metabolism-of-carbohydrates | 237 | 3.16e-04 | 3.13e-03 | 0.1040 | 0.1020 | 0.017100 | 6.78e-03 | 6.50e-01 |
| Diseases-of-glycosylation | 113 | 1.33e-06 | 2.82e-05 | 0.3390 | 0.2780 | 0.193000 | 3.33e-07 | 3.94e-04 |
| Chondroitin-sulfate/dermatan-sulfate-metabolism | 42 | 1.03e-08 | 3.30e-07 | 0.7070 | 0.5400 | 0.456000 | 1.42e-09 | 3.11e-07 |
| Interferon-Signaling | 141 | 9.06e-03 | 4.77e-02 | 0.1080 | 0.0235 | 0.106000 | 6.31e-01 | 3.03e-02 |
| Defects-in-vitamin-and-cofactor-metabolism | 20 | 1.95e-04 | 2.08e-03 | 0.6990 | -0.4520 | -0.533000 | 4.61e-04 | 3.72e-05 |
| Metabolism-of-porphyrins | 19 | 5.53e-03 | 3.25e-02 | 0.5510 | -0.3480 | -0.427000 | 8.69e-03 | 1.26e-03 |
| Pink/Parkin-Mediated-Mitophagy | 20 | 1.23e-03 | 9.40e-03 | 0.6160 | -0.4730 | -0.394000 | 2.54e-04 | 2.26e-03 |
| Vesicle-mediated-transport | 560 | 1.04e-07 | 2.77e-06 | 0.1020 | 0.0998 | 0.022400 | 5.99e-05 | 3.68e-01 |
| Sphingolipid-metabolism | 67 | 6.93e-03 | 3.89e-02 | 0.2540 | 0.2140 | 0.137000 | 2.45e-03 | 5.24e-02 |
| tRNA-Aminoacylation | 26 | 4.87e-08 | 1.35e-06 | 0.8700 | -0.6520 | -0.576000 | 8.49e-09 | 3.70e-07 |
| Mitochondrial-protein-import | 57 | 8.67e-23 | 8.53e-21 | 1.0300 | -0.7620 | -0.686000 | 2.29e-23 | 2.95e-19 |
| Glucose-metabolism | 79 | 1.57e-04 | 1.78e-03 | 0.3330 | -0.1950 | -0.270000 | 2.73e-03 | 3.44e-05 |
| EPH-Ephrin-signaling | 82 | 2.92e-04 | 2.94e-03 | 0.3120 | 0.2540 | 0.180000 | 6.99e-05 | 4.81e-03 |
| Diseases-associated-with-glycosaminoglycan-metabolism | 34 | 7.91e-06 | 1.51e-04 | 0.6280 | 0.4790 | 0.406000 | 1.31e-06 | 4.26e-05 |
| Deubiquitination | 220 | 8.02e-03 | 4.35e-02 | 0.0625 | -0.0613 | 0.012100 | 1.18e-01 | 7.58e-01 |
| Intraflagellar-transport | 36 | 1.85e-03 | 1.33e-02 | 0.4350 | 0.3420 | 0.269000 | 3.92e-04 | 5.28e-03 |
| Mitochondrial-translation-initiation | 88 | 1.35e-40 | 2.16e-38 | 1.1100 | -0.8210 | -0.750000 | 1.25e-40 | 4.30e-34 |
| ECM-proteoglycans | 43 | 3.42e-13 | 1.90e-11 | 0.8860 | 0.6610 | 0.590000 | 6.20e-14 | 2.23e-11 |
| CS/DS-degradation | 11 | 3.22e-04 | 3.17e-03 | 0.9280 | 0.6200 | 0.691000 | 3.74e-04 | 7.28e-05 |
| rRNA-processing-in-the-mitochondrion | 22 | 1.56e-11 | 7.41e-10 | 1.1600 | -0.7830 | -0.854000 | 2.00e-10 | 3.93e-12 |
| Pyruvate-metabolism | 27 | 5.41e-08 | 1.47e-06 | 0.8530 | -0.5670 | -0.637000 | 3.40e-07 | 9.95e-09 |
| Gluconeogenesis | 26 | 9.45e-05 | 1.18e-03 | 0.6400 | -0.4170 | -0.486000 | 2.36e-04 | 1.78e-05 |
| Mitochondrial-translation-elongation | 88 | 2.90e-41 | 6.18e-39 | 1.1200 | -0.8270 | -0.758000 | 3.38e-41 | 8.11e-35 |
| Mitochondrial-translation-termination | 88 | 4.51e-41 | 8.23e-39 | 1.1200 | -0.8250 | -0.756000 | 5.15e-41 | 1.18e-34 |
| Assembly-of-collagen-fibrils-and-other-multimeric-structures | 46 | 8.17e-11 | 3.17e-09 | 0.7690 | 0.5760 | 0.509000 | 1.34e-11 | 2.38e-09 |
| Mitochondrial-translation | 94 | 6.95e-44 | 1.78e-41 | 1.1200 | -0.8250 | -0.758000 | 1.11e-43 | 4.24e-37 |
| Platelet-degranulation | 108 | 9.24e-05 | 1.17e-03 | 0.2960 | 0.2380 | 0.175000 | 1.91e-05 | 1.69e-03 |
| O-glycosylation-of-TSR-domain-containing-proteins | 33 | 1.99e-04 | 2.10e-03 | 0.5440 | 0.4140 | 0.352000 | 3.79e-05 | 4.70e-04 |
| Signaling-by-Retinoic-Acid | 32 | 1.88e-03 | 1.35e-02 | 0.4700 | -0.3000 | -0.362000 | 3.36e-03 | 3.98e-04 |
| Regulation-of-pyruvate-dehydrogenase-(PDH)-complex | 15 | 2.55e-05 | 4.24e-04 | 0.9140 | -0.6150 | -0.676000 | 3.77e-05 | 5.76e-06 |
| Mitotic-Prometaphase | 174 | 1.97e-03 | 1.39e-02 | 0.1680 | 0.1450 | 0.084200 | 1.00e-03 | 5.59e-02 |
| Fatty-acid-metabolism | 131 | 2.54e-11 | 1.16e-09 | 0.4600 | -0.2940 | -0.353000 | 6.46e-09 | 2.95e-12 |
| Regulation-of-lipid-metabolism-by-PPARalpha | 111 | 1.88e-04 | 2.04e-03 | 0.2820 | -0.1680 | -0.226000 | 2.28e-03 | 3.88e-05 |
| mTOR-signalling | 37 | 4.57e-03 | 2.78e-02 | 0.4030 | -0.2540 | -0.312000 | 7.41e-03 | 1.03e-03 |
| Autophagy | 110 | 8.95e-03 | 4.73e-02 | 0.1960 | -0.1080 | -0.164000 | 5.14e-02 | 2.97e-03 |
| PPARA-activates-gene-expression | 109 | 1.93e-04 | 2.08e-03 | 0.2860 | -0.1720 | -0.228000 | 1.94e-03 | 3.85e-05 |
| Metabolism-of-lipids | 575 | 1.26e-10 | 4.72e-09 | 0.1910 | -0.1040 | -0.160000 | 2.19e-05 | 7.10e-11 |
| Macroautophagy | 99 | 4.33e-03 | 2.67e-02 | 0.2320 | -0.1340 | -0.189000 | 2.17e-02 | 1.16e-03 |
| Non-integrin-membrane-ECM-interactions | 41 | 1.74e-06 | 3.49e-05 | 0.6150 | 0.4610 | 0.406000 | 3.18e-07 | 6.74e-06 |
| mTORC1-mediated-signalling | 20 | 5.39e-03 | 3.22e-02 | 0.5500 | -0.3610 | -0.415000 | 5.17e-03 | 1.30e-03 |
| Post-translational-protein-modification | 1122 | 8.61e-07 | 1.93e-05 | 0.0627 | 0.0621 | 0.008380 | 5.27e-04 | 6.40e-01 |
| Transcriptional-activation-of-mitochondrial-biogenesis | 51 | 3.86e-08 | 1.10e-06 | 0.6280 | -0.4180 | -0.468000 | 2.43e-07 | 7.23e-09 |
| Signaling-by-Receptor-Tyrosine-Kinases | 390 | 1.34e-06 | 2.82e-05 | 0.1790 | 0.1490 | 0.099200 | 4.50e-07 | 8.10e-04 |
| Metabolism-of-proteins | 1577 | 1.20e-07 | 3.14e-06 | 0.0624 | -0.0131 | -0.061000 | 3.93e-01 | 7.33e-05 |
| Keratan-sulfate/keratin-metabolism | 27 | 3.04e-03 | 1.95e-02 | 0.5000 | 0.3760 | 0.329000 | 7.15e-04 | 3.07e-03 |
| Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins. | 120 | 4.61e-65 | 2.95e-62 | 1.2200 | -0.8830 | -0.836000 | 5.28e-63 | 1.12e-56 |
| Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS) | 32 | 4.00e-04 | 3.74e-03 | 0.5350 | 0.4010 | 0.355000 | 8.77e-05 | 5.08e-04 |
| Respiratory-electron-transport | 100 | 4.63e-57 | 1.97e-54 | 1.2500 | -0.9040 | -0.859000 | 2.80e-55 | 4.76e-50 |
| Mitochondrial-tRNA-aminoacylation | 19 | 3.66e-08 | 1.06e-06 | 1.0400 | -0.7560 | -0.712000 | 1.14e-08 | 7.59e-08 |
| Cristae-formation | 29 | 4.27e-17 | 3.22e-15 | 1.2500 | -0.9050 | -0.861000 | 3.21e-17 | 9.79e-16 |
| Cilium-Assembly | 176 | 4.78e-05 | 6.95e-04 | 0.2470 | 0.1950 | 0.152000 | 8.38e-06 | 5.08e-04 |
| Keratan-sulfate-degradation | 10 | 6.99e-04 | 5.96e-03 | 0.9320 | 0.6800 | 0.638000 | 1.95e-04 | 4.80e-04 |
| Fcgamma-receptor-(FCGR)-dependent-phagocytosis | 82 | 3.49e-04 | 3.35e-03 | 0.3320 | 0.2130 | 0.255000 | 8.87e-04 | 6.69e-05 |
| Extracellular-matrix-organization | 228 | 1.35e-38 | 1.92e-36 | 0.6770 | 0.4990 | 0.458000 | 1.41e-38 | 1.08e-32 |
| Response-to-elevated-platelet-cytosolic-Ca2+ | 113 | 1.45e-04 | 1.69e-03 | 0.2960 | 0.2290 | 0.188000 | 2.63e-05 | 5.63e-04 |
| Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs) | 84 | 4.05e-09 | 1.36e-07 | 0.5210 | 0.3890 | 0.347000 | 7.59e-10 | 3.74e-08 |
| Disease | 881 | 8.96e-04 | 7.40e-03 | 0.0553 | 0.0538 | 0.012800 | 7.31e-03 | 5.24e-01 |
| Defects-in-cobalamin-(B12)-metabolism | 12 | 1.10e-03 | 8.65e-03 | 0.8230 | -0.5620 | -0.602000 | 7.53e-04 | 3.04e-04 |
| Kinesins | 35 | 8.36e-04 | 7.04e-03 | 0.4880 | 0.3640 | 0.325000 | 1.92e-04 | 8.91e-04 |
| Molecules-associated-with-elastic-fibres | 28 | 1.45e-06 | 2.98e-05 | 0.7580 | 0.5160 | 0.554000 | 2.25e-06 | 3.82e-07 |
| Post-translational-protein-phosphorylation | 77 | 2.65e-08 | 7.88e-07 | 0.5180 | 0.3850 | 0.348000 | 5.49e-09 | 1.34e-07 |
| Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle | 51 | 4.48e-21 | 4.10e-19 | 1.0500 | -0.7250 | -0.760000 | 3.15e-19 | 5.37e-21 |
| Mitophagy | 27 | 4.58e-04 | 4.17e-03 | 0.5820 | -0.4290 | -0.394000 | 1.16e-04 | 3.92e-04 |
| Mitochondrial-iron-sulfur-cluster-biogenesis | 10 | 6.99e-05 | 9.35e-04 | 1.0700 | -0.7410 | -0.775000 | 4.95e-05 | 2.19e-05 |
| Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism | 13 | 8.93e-03 | 4.73e-02 | 0.6590 | -0.4500 | -0.481000 | 4.98e-03 | 2.66e-03 |
| EPHB-mediated-forward-signaling | 32 | 2.71e-03 | 1.77e-02 | 0.4690 | 0.3460 | 0.316000 | 7.13e-04 | 1.97e-03 |
| Sulfur-amino-acid-metabolism | 20 | 3.47e-04 | 3.35e-03 | 0.6910 | -0.4750 | -0.502000 | 2.39e-04 | 1.00e-04 |
| RNA-Polymerase-II-Transcription | 957 | 2.44e-03 | 1.64e-02 | 0.0699 | -0.0337 | -0.061200 | 8.07e-02 | 1.51e-03 |
| Gene-expression-(Transcription) | 1076 | 2.07e-03 | 1.45e-02 | 0.0654 | -0.0304 | -0.057800 | 9.59e-02 | 1.55e-03 |
| Complex-I-biogenesis | 54 | 1.62e-33 | 2.07e-31 | 1.3000 | -0.9300 | -0.904000 | 2.28e-32 | 1.25e-30 |
| Mitochondrial-biogenesis | 88 | 1.70e-19 | 1.45e-17 | 0.7690 | -0.5300 | -0.557000 | 7.78e-18 | 1.67e-19 |
| Metabolism-of-water-soluble-vitamins-and-cofactors | 103 | 3.97e-03 | 2.46e-02 | 0.2500 | -0.1630 | -0.189000 | 4.25e-03 | 9.27e-04 |
| Heme-biosynthesis | 12 | 5.39e-04 | 4.76e-03 | 0.8680 | -0.6010 | -0.627000 | 3.12e-04 | 1.70e-04 |
| Protein-localization | 142 | 7.41e-29 | 7.90e-27 | 0.7420 | -0.5120 | -0.537000 | 6.06e-26 | 2.04e-28 |
| Metabolism | 1613 | 5.51e-49 | 1.76e-46 | 0.3000 | -0.2000 | -0.224000 | 1.76e-39 | 2.43e-49 |
| Signaling-by-PDGF | 48 | 6.72e-04 | 5.77e-03 | 0.4260 | 0.3130 | 0.289000 | 1.75e-04 | 5.29e-04 |
| Signal-Transduction | 1697 | 3.11e-13 | 1.81e-11 | 0.1440 | 0.1130 | 0.089900 | 3.26e-14 | 1.55e-09 |
| The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport | 167 | 1.25e-82 | 1.60e-79 | 1.1700 | -0.8350 | -0.813000 | 5.14e-78 | 5.46e-74 |
| Metabolism-of-cofactors | 18 | 6.03e-07 | 1.40e-05 | 0.9790 | -0.7030 | -0.681000 | 2.41e-07 | 5.56e-07 |
| Platelet-activation,-signaling-and-aggregation | 214 | 2.24e-04 | 2.33e-03 | 0.2150 | 0.1620 | 0.141000 | 4.52e-05 | 3.93e-04 |
| Hemostasis | 440 | 2.40e-06 | 4.72e-05 | 0.1870 | 0.1420 | 0.121000 | 3.95e-07 | 1.39e-05 |
| Chondroitin-sulfate-biosynthesis | 16 | 4.32e-05 | 6.35e-04 | 0.8700 | 0.6250 | 0.605000 | 1.52e-05 | 2.75e-05 |
| Collagen-biosynthesis-and-modifying-enzymes | 56 | 1.44e-17 | 1.15e-15 | 0.9140 | 0.6370 | 0.655000 | 1.59e-16 | 2.10e-17 |
| Metabolism-of-vitamins-and-cofactors | 153 | 2.20e-03 | 1.51e-02 | 0.2180 | -0.1450 | -0.163000 | 2.06e-03 | 5.27e-04 |
| Signaling-by-Rho-GTPases | 340 | 1.22e-06 | 2.65e-05 | 0.2190 | 0.1460 | 0.164000 | 3.89e-06 | 2.40e-07 |
| Transport-of-small-molecules | 492 | 7.64e-03 | 4.20e-02 | 0.1070 | -0.0672 | -0.082600 | 1.11e-02 | 1.80e-03 |
| Syndecan-interactions | 20 | 7.01e-05 | 9.35e-04 | 0.7590 | 0.5440 | 0.529000 | 2.50e-05 | 4.16e-05 |
| Cytokine-Signaling-in-Immune-system | 610 | 7.31e-04 | 6.19e-03 | 0.1180 | 0.0757 | 0.090600 | 1.52e-03 | 1.46e-04 |
| Mitochondrial-calcium-ion-transport | 21 | 1.53e-04 | 1.76e-03 | 0.7100 | -0.4950 | -0.509000 | 8.64e-05 | 5.32e-05 |
| Formation-of-ATP-by-chemiosmotic-coupling | 16 | 1.29e-10 | 4.72e-09 | 1.3100 | -0.9330 | -0.919000 | 1.02e-10 | 1.89e-10 |
| Transcriptional-Regulation-by-TP53 | 334 | 6.12e-03 | 3.51e-02 | 0.1350 | -0.1010 | -0.088400 | 1.50e-03 | 5.66e-03 |
| Immune-System | 1477 | 5.03e-07 | 1.19e-05 | 0.1120 | 0.0850 | 0.072600 | 7.86e-08 | 4.51e-06 |
| Branched-chain-amino-acid-catabolism | 19 | 5.85e-11 | 2.49e-09 | 1.2200 | -0.8590 | -0.871000 | 9.04e-11 | 4.89e-11 |
| Synthesis-of-PA | 27 | 8.76e-03 | 4.70e-02 | 0.4600 | -0.3310 | -0.319000 | 2.91e-03 | 4.10e-03 |
| Translation | 241 | 4.00e-31 | 4.66e-29 | 0.5950 | -0.4150 | -0.426000 | 1.35e-28 | 4.55e-30 |
| RHO-GTPase-Effectors | 220 | 2.69e-05 | 4.30e-04 | 0.2410 | 0.1650 | 0.175000 | 2.50e-05 | 7.61e-06 |
| Metabolism-of-amino-acids-and-derivatives | 256 | 1.02e-11 | 5.03e-10 | 0.3470 | -0.2410 | -0.251000 | 3.75e-11 | 5.47e-12 |
| mRNA-Splicing---Major-Pathway | 172 | 1.87e-05 | 3.27e-04 | 0.2770 | -0.1910 | -0.201000 | 1.53e-05 | 5.88e-06 |
| Integrin-cell-surface-interactions | 53 | 1.23e-07 | 3.14e-06 | 0.6020 | 0.4300 | 0.421000 | 5.95e-08 | 1.12e-07 |
| Mitochondrial-Fatty-Acid-Beta-Oxidation | 31 | 5.13e-17 | 3.65e-15 | 1.2100 | -0.8580 | -0.850000 | 1.25e-16 | 2.49e-16 |
| Diseases-associated-with-O-glycosylation-of-proteins | 46 | 3.63e-03 | 2.28e-02 | 0.3840 | 0.2760 | 0.268000 | 1.23e-03 | 1.70e-03 |
| Cellular-responses-to-stress | 435 | 8.10e-03 | 4.37e-02 | 0.1160 | -0.0786 | -0.085800 | 5.16e-03 | 2.26e-03 |
| Metabolism-of-RNA | 619 | 1.46e-07 | 3.67e-06 | 0.1780 | -0.1290 | -0.123000 | 4.75e-08 | 2.26e-07 |
| Citric-acid-cycle-(TCA-cycle) | 22 | 2.51e-13 | 1.53e-11 | 1.2600 | -0.8940 | -0.889000 | 3.71e-13 | 5.02e-13 |
| Innate-Immune-System | 746 | 7.02e-03 | 3.91e-02 | 0.0913 | 0.0670 | 0.062100 | 2.01e-03 | 4.21e-03 |
| Processing-of-Capped-Intron-Containing-Pre-mRNA | 230 | 1.11e-05 | 2.06e-04 | 0.2460 | -0.1720 | -0.177000 | 7.62e-06 | 4.18e-06 |
| Collagen-formation | 75 | 1.22e-16 | 8.24e-15 | 0.7690 | 0.5460 | 0.542000 | 3.06e-16 | 4.96e-16 |
| Glyoxylate-metabolism-and-glycine-degradation | 25 | 7.78e-11 | 3.12e-09 | 1.0600 | -0.7510 | -0.748000 | 7.74e-11 | 9.53e-11 |
| Collagen-chain-trimerization | 33 | 1.12e-13 | 7.15e-12 | 1.0400 | 0.7370 | 0.740000 | 2.34e-13 | 1.79e-13 |
| Neddylation | 210 | 2.19e-03 | 1.51e-02 | 0.1890 | -0.1350 | -0.132000 | 7.60e-04 | 1.01e-03 |
| Regulation-of-actin-dynamics-for-phagocytic-cup-formation | 59 | 2.59e-03 | 1.70e-02 | 0.3500 | 0.2460 | 0.249000 | 1.10e-03 | 9.59e-04 |
| TP53-Regulates-Metabolic-Genes | 85 | 1.59e-07 | 3.92e-06 | 0.4720 | -0.3350 | -0.333000 | 9.34e-08 | 1.13e-07 |
| Glycerophospholipid-biosynthesis | 102 | 1.98e-05 | 3.42e-04 | 0.3590 | -0.2530 | -0.255000 | 1.02e-05 | 8.93e-06 |
| NCAM1-interactions | 30 | 8.78e-03 | 4.70e-02 | 0.4370 | 0.3080 | 0.310000 | 3.50e-03 | 3.34e-03 |
| mRNA-Splicing | 180 | 2.48e-05 | 4.17e-04 | 0.2680 | -0.1900 | -0.189000 | 1.16e-05 | 1.20e-05 |
| Elastic-fibre-formation | 38 | 7.80e-11 | 3.12e-09 | 0.8600 | 0.6080 | 0.608000 | 8.52e-11 | 8.68e-11 |
| tRNA-processing | 116 | 2.53e-04 | 2.59e-03 | 0.2950 | -0.2080 | -0.208000 | 1.08e-04 | 1.08e-04 |
Detailed Gene set reports
Termination-of-O-glycan-biosynthesis
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00112 |
| p.adjustMANOVA | 0.0087 |
| s.dist | 0.391 |
| s.young | 0.391 |
| s.old | -0.00526 |
| p.young | 0.0324 |
| p.old | 0.977 |
| Gene | young | old |
|---|---|---|
| St3gal4 | 4466 | -4957 |
| St6galnac2 | 5684 | -2059 |
| St6gal1 | 4351 | -2022 |
| St6galnac3 | 48 | -5018 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Muc15 | 6986 | 6914 |
| Muc16 | -1221 | -3095 |
| St3gal1 | 3058 | 716 |
| St3gal2 | 6995 | 5852 |
| St3gal3 | -6777 | -6624 |
| St3gal4 | 4466 | -4957 |
| St6gal1 | 4351 | -2022 |
| St6galnac2 | 5684 | -2059 |
| St6galnac3 | 48 | -5018 |
| St6galnac4 | 6331 | 6062 |
Presynaptic-depolarization-and-calcium-channel-opening
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00206 |
| p.adjustMANOVA | 0.0145 |
| s.dist | 0.396 |
| s.young | 0.0225 |
| s.old | 0.395 |
| p.young | 0.902 |
| p.old | 0.0306 |
| Gene | young | old |
|---|---|---|
| Cacnb1 | 7379 | 6564 |
| Cacnb3 | 6991 | 5679 |
| Cacna1e | 3836 | 2997 |
| Cacna2d1 | 2938 | 1584 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cacfd1 | -4976 | -5163 |
| Cacna1a | -3426 | 5118 |
| Cacna1e | 3836 | 2997 |
| Cacna2d1 | 2938 | 1584 |
| Cacna2d2 | -232 | 3850 |
| Cacna2d3 | -2618 | 5379 |
| Cacnb1 | 7379 | 6564 |
| Cacnb2 | -5371 | -6792 |
| Cacnb3 | 6991 | 5679 |
| Cacnb4 | -1978 | 6296 |
Synaptic-adhesion-like-molecules
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00173 |
| p.adjustMANOVA | 0.0127 |
| s.dist | 0.285 |
| s.young | 0.283 |
| s.old | -0.0347 |
| p.young | 0.0576 |
| p.old | 0.816 |
| Gene | young | old |
|---|---|---|
| Lrfn3 | 2693 | -2907 |
| Ptprd | 1609 | -4417 |
| Lrfn1 | 3108 | -1921 |
| Lrfn4 | 1425 | -3569 |
| Grin2c | 791 | -5559 |
| Grin2d | 5624 | -588 |
| Dlg1 | 1311 | -1704 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Dlg1 | 1311 | -1704 |
| Dlg3 | 4869 | 4306 |
| Dlg4 | 6131 | 5964 |
| Flot1 | -4409 | -5145 |
| Flot2 | -2856 | -1772 |
| Gria3 | 7251 | 6760 |
| Grin2c | 791 | -5559 |
| Grin2d | 5624 | -588 |
| Lrfn1 | 3108 | -1921 |
| Lrfn3 | 2693 | -2907 |
| Lrfn4 | 1425 | -3569 |
| Ptprd | 1609 | -4417 |
| Ptprf | 3330 | 5754 |
| Ptprs | 6547 | 183 |
| Rtn3 | -4548 | -5017 |
Interferon-alpha/beta-signaling
| metric | value |
|---|---|
| setSize | 40 |
| pMANOVA | 1.39e-08 |
| p.adjustMANOVA | 4.33e-07 |
| s.dist | 0.363 |
| s.young | 0.0479 |
| s.old | 0.36 |
| p.young | 0.601 |
| p.old | 8.18e-05 |
| Gene | young | old |
|---|---|---|
| Irf5 | 6574 | 5961 |
| Ip6k2 | 5972 | 5125 |
| Irf8 | 6762 | 4110 |
| Ifit2 | 4223 | 6292 |
| Ifit3b | 4145 | 5674 |
| Oas3 | 4123 | 5233 |
| Ptpn1 | 4586 | 4701 |
| Egr1 | 6800 | 2934 |
| Tyk2 | 3861 | 4516 |
| Ifnar1 | 4856 | 3153 |
| Mx1 | 2461 | 4874 |
| Isg15 | 1534 | 5220 |
| Socs1 | 1854 | 3043 |
| Psmb8 | 188 | 2895 |
| Irf2 | 20 | 1727 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abce1 | -693 | -1645 |
| Adar | -1009 | 3485 |
| Bst2 | -4223 | 4477 |
| Egr1 | 6800 | 2934 |
| Ifi35 | -3130 | 4433 |
| Ifit2 | 4223 | 6292 |
| Ifit3b | 4145 | 5674 |
| Ifnar1 | 4856 | 3153 |
| Ifnar2 | 2104 | -5943 |
| Ip6k2 | 5972 | 5125 |
| Irf1 | -3783 | -2366 |
| Irf2 | 20 | 1727 |
| Irf3 | -2892 | -808 |
| Irf4 | -4725 | -5939 |
| Irf5 | 6574 | 5961 |
| Irf6 | 2842 | -1207 |
| Irf7 | -70 | 6216 |
| Irf8 | 6762 | 4110 |
| Irf9 | -611 | 5700 |
| Isg15 | 1534 | 5220 |
| Isg20 | -1498 | 4375 |
| Jak1 | -2505 | -6853 |
| Mx1 | 2461 | 4874 |
| Oas2 | -1450 | 4847 |
| Oas3 | 4123 | 5233 |
| Oasl1 | -8 | 5668 |
| Psmb8 | 188 | 2895 |
| Ptpn1 | 4586 | 4701 |
| Ptpn11 | -3358 | -3525 |
| Ptpn6 | -2833 | 1877 |
| Rnasel | 4220 | -1796 |
| Rsad2 | -6088 | 1479 |
| Samhd1 | -4358 | -5556 |
| Socs1 | 1854 | 3043 |
| Socs3 | 2520 | -1464 |
| Stat1 | -1595 | 3287 |
| Stat2 | -3094 | 5004 |
| Tyk2 | 3861 | 4516 |
| Usp18 | -2557 | 6813 |
| Xaf1 | -1484 | 5451 |
The-canonical-retinoid-cycle-in-rods-(twilight-vision)
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000409 |
| p.adjustMANOVA | 0.00379 |
| s.dist | 0.609 |
| s.young | 0.245 |
| s.old | 0.557 |
| p.young | 0.141 |
| p.old | 0.000831 |
| Gene | young | old |
|---|---|---|
| Rbp1 | 7370 | 6838 |
| Napepld | 7118 | 6773 |
| Rbp4 | 6701 | 6970 |
| Rdh11 | 6388 | 6267 |
| Dhrs9 | 4412 | 6006 |
| Cyp4v3 | 1947 | 2922 |
| Rdh5 | 2259 | 2260 |
| Myo7a | 372 | 5690 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abca4 | -6708 | 103 |
| Cyp4v3 | 1947 | 2922 |
| Dhrs9 | 4412 | 6006 |
| Lrat | -5855 | -3045 |
| Myo7a | 372 | 5690 |
| Napepld | 7118 | 6773 |
| Rbp1 | 7370 | 6838 |
| Rbp4 | 6701 | 6970 |
| Rdh10 | 1223 | -2164 |
| Rdh11 | 6388 | 6267 |
| Rdh5 | 2259 | 2260 |
| Ttr | -2307 | 6470 |
N-glycan-antennae-elongation-in-the-medial/trans-Golgi
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000241 |
| p.adjustMANOVA | 0.00249 |
| s.dist | 0.355 |
| s.young | 0.351 |
| s.old | 0.0531 |
| p.young | 0.00662 |
| p.old | 0.681 |
| Gene | young | old |
|---|---|---|
| B4galt6 | 6036 | 6103 |
| B4galt5 | 6407 | 5561 |
| B4galt2 | 6315 | 4664 |
| Chst10 | 4959 | 4476 |
| St8sia2 | 4491 | 4888 |
| Fuca1 | 5465 | 3412 |
| Mgat2 | 5212 | 2395 |
| Man2a1 | 2682 | 1662 |
| B4galt1 | 3267 | 1068 |
| Mgat4a | 2446 | 753 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| B4galt1 | 3267 | 1068 |
| B4galt2 | 6315 | 4664 |
| B4galt3 | -4310 | -1405 |
| B4galt4 | -4249 | -652 |
| B4galt5 | 6407 | 5561 |
| B4galt6 | 6036 | 6103 |
| Chst10 | 4959 | 4476 |
| Fuca1 | 5465 | 3412 |
| Fut8 | 5119 | -1697 |
| Man2a1 | 2682 | 1662 |
| Man2a2 | 3550 | -4096 |
| Mgat2 | 5212 | 2395 |
| Mgat3 | 4996 | -6874 |
| Mgat4a | 2446 | 753 |
| Mgat4b | -4283 | -4924 |
| Mgat5 | -1543 | -3594 |
| St3gal4 | 4466 | -4957 |
| St6gal1 | 4351 | -2022 |
| St8sia2 | 4491 | 4888 |
| St8sia6 | -1521 | -4549 |
Chemokine-receptors-bind-chemokines
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.0025 |
| p.adjustMANOVA | 0.0165 |
| s.dist | 0.303 |
| s.young | 0.299 |
| s.old | 0.0474 |
| p.young | 0.0205 |
| p.old | 0.714 |
| Gene | young | old |
|---|---|---|
| Cxcr6 | 7346 | 5824 |
| Cxcl10 | 6404 | 6503 |
| Ackr4 | 7184 | 5570 |
| Ackr2 | 6213 | 5741 |
| Cxcl16 | 6525 | 4852 |
| Cx3cl1 | 5319 | 4905 |
| Cx3cr1 | 2594 | 4915 |
| Ccr1 | 4784 | 1307 |
| Ccr10 | 1614 | 1451 |
| Xcr1 | 4390 | 72 |
| Ccr5 | 126 | 20 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ackr2 | 6213 | 5741 |
| Ackr3 | -5232 | -1642 |
| Ackr4 | 7184 | 5570 |
| Ccl2 | 2195 | -4721 |
| Ccl7 | 3952 | -5153 |
| Ccr1 | 4784 | 1307 |
| Ccr10 | 1614 | 1451 |
| Ccr2 | 5608 | -3576 |
| Ccr5 | 126 | 20 |
| Ccrl2 | -5124 | -6524 |
| Cx3cl1 | 5319 | 4905 |
| Cx3cr1 | 2594 | 4915 |
| Cxcl10 | 6404 | 6503 |
| Cxcl12 | -2702 | -7116 |
| Cxcl16 | 6525 | 4852 |
| Cxcl9 | -5835 | -4523 |
| Cxcr4 | -5386 | -5393 |
| Cxcr6 | 7346 | 5824 |
| Ppbp | 6229 | -3145 |
| Xcr1 | 4390 | 72 |
O-linked-glycosylation-of-mucins
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 1.25e-05 |
| p.adjustMANOVA | 0.000229 |
| s.dist | 0.411 |
| s.young | 0.386 |
| s.old | 0.141 |
| p.young | 0.000155 |
| p.old | 0.169 |
| Gene | young | old |
|---|---|---|
| Muc15 | 6986 | 6914 |
| B3gnt9 | 7252 | 6495 |
| Gcnt1 | 6989 | 6668 |
| Gcnt4 | 7114 | 6388 |
| St3gal2 | 6995 | 5852 |
| B3gnt2 | 6711 | 5903 |
| St6galnac4 | 6331 | 6062 |
| Galnt7 | 6155 | 6218 |
| B4galt6 | 6036 | 6103 |
| B4galt5 | 6407 | 5561 |
| Galnt4 | 6322 | 3680 |
| B3gnt8 | 3406 | 3537 |
| Galnt10 | 2930 | 4030 |
| Galnt2 | 5385 | 1538 |
| B3gntl1 | 2489 | 2271 |
| B3gnt5 | 4473 | 902 |
| St3gal1 | 3058 | 716 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| B3gnt2 | 6711 | 5903 |
| B3gnt3 | -5788 | -6546 |
| B3gnt5 | 4473 | 902 |
| B3gnt8 | 3406 | 3537 |
| B3gnt9 | 7252 | 6495 |
| B3gntl1 | 2489 | 2271 |
| B4galt5 | 6407 | 5561 |
| B4galt6 | 6036 | 6103 |
| C1galt1 | -3822 | -3973 |
| C1galt1c1 | -850 | 202 |
| Galnt1 | -866 | -4743 |
| Galnt10 | 2930 | 4030 |
| Galnt11 | -1695 | -4085 |
| Galnt15 | -5397 | -6655 |
| Galnt16 | 6303 | -4778 |
| Galnt17 | 5038 | -3051 |
| Galnt18 | 41 | -332 |
| Galnt2 | 5385 | 1538 |
| Galnt4 | 6322 | 3680 |
| Galnt7 | 6155 | 6218 |
| Gcnt1 | 6989 | 6668 |
| Gcnt4 | 7114 | 6388 |
| Muc15 | 6986 | 6914 |
| Muc16 | -1221 | -3095 |
| St3gal1 | 3058 | 716 |
| St3gal2 | 6995 | 5852 |
| St3gal3 | -6777 | -6624 |
| St3gal4 | 4466 | -4957 |
| St6gal1 | 4351 | -2022 |
| St6galnac2 | 5684 | -2059 |
| St6galnac3 | 48 | -5018 |
| St6galnac4 | 6331 | 6062 |
HS-GAG-biosynthesis
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.000116 |
| p.adjustMANOVA | 0.00141 |
| s.dist | 0.475 |
| s.young | 0.434 |
| s.old | 0.192 |
| p.young | 0.000313 |
| p.old | 0.112 |
| Gene | young | old |
|---|---|---|
| Sdc2 | 7435 | 6631 |
| Hs2st1 | 7325 | 6476 |
| Ext1 | 6621 | 6756 |
| Gpc6 | 6891 | 6273 |
| Slc35d2 | 6737 | 5737 |
| Sdc1 | 7061 | 4784 |
| Hs6st1 | 6013 | 5322 |
| Hs3st3a1 | 6472 | 4761 |
| Hspg2 | 6535 | 3769 |
| Sdc3 | 4012 | 3827 |
| Ndst2 | 4415 | 2740 |
| Ndst3 | 3651 | 3254 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Agrn | -247 | 199 |
| Ext1 | 6621 | 6756 |
| Ext2 | 1986 | -1619 |
| Glce | 179 | -4014 |
| Gpc1 | -3801 | -4293 |
| Gpc3 | 2127 | -5769 |
| Gpc4 | -3619 | -6582 |
| Gpc6 | 6891 | 6273 |
| Hs2st1 | 7325 | 6476 |
| Hs3st1 | -493 | -13 |
| Hs3st3a1 | 6472 | 4761 |
| Hs3st3b1 | 1722 | -4410 |
| Hs6st1 | 6013 | 5322 |
| Hs6st2 | 2526 | -4992 |
| Hspg2 | 6535 | 3769 |
| Ndst1 | -1729 | -4940 |
| Ndst2 | 4415 | 2740 |
| Ndst3 | 3651 | 3254 |
| Sdc1 | 7061 | 4784 |
| Sdc2 | 7435 | 6631 |
| Sdc3 | 4012 | 3827 |
| Sdc4 | 4355 | -9 |
| Slc35d2 | 6737 | 5737 |
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00529 |
| p.adjustMANOVA | 0.0318 |
| s.dist | 0.492 |
| s.young | 0.446 |
| s.old | 0.206 |
| p.young | 0.00533 |
| p.old | 0.198 |
| Gene | young | old |
|---|---|---|
| Fzd2 | 7468 | 6862 |
| Cltb | 6447 | 5854 |
| Ror2 | 5904 | 5574 |
| Ap2b1 | 5061 | 4756 |
| Ror1 | 5976 | 2939 |
| Ap2s1 | 1934 | 322 |
| Ap2m1 | 1964 | 309 |
| Cltc | 2485 | 6 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ap2a1 | 4766 | -1188 |
| Ap2a2 | 1207 | -4356 |
| Ap2b1 | 5061 | 4756 |
| Ap2m1 | 1964 | 309 |
| Ap2s1 | 1934 | 322 |
| Clta | 2287 | -631 |
| Cltb | 6447 | 5854 |
| Cltc | 2485 | 6 |
| Fzd2 | 7468 | 6862 |
| Fzd5 | 977 | -1199 |
| Ror1 | 5976 | 2939 |
| Ror2 | 5904 | 5574 |
| Wnt5a | -2222 | -4294 |
HS-GAG-degradation
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.00047 |
| p.adjustMANOVA | 0.00423 |
| s.dist | 0.526 |
| s.young | 0.471 |
| s.old | 0.234 |
| p.young | 0.000546 |
| p.old | 0.0852 |
| Gene | young | old |
|---|---|---|
| Sdc2 | 7435 | 6631 |
| Gpc6 | 6891 | 6273 |
| Sdc1 | 7061 | 4784 |
| Ids | 6784 | 4640 |
| Sgsh | 6079 | 5115 |
| Gusb | 6165 | 4930 |
| Glb1l | 5086 | 5055 |
| Hspg2 | 6535 | 3769 |
| Sdc3 | 4012 | 3827 |
| Naglu | 4598 | 2203 |
| Glb1 | 5822 | 1047 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Agrn | -247 | 199 |
| Glb1 | 5822 | 1047 |
| Glb1l | 5086 | 5055 |
| Gpc1 | -3801 | -4293 |
| Gpc3 | 2127 | -5769 |
| Gpc4 | -3619 | -6582 |
| Gpc6 | 6891 | 6273 |
| Gusb | 6165 | 4930 |
| Hpse | 4346 | -2233 |
| Hspg2 | 6535 | 3769 |
| Ids | 6784 | 4640 |
| Idua | -5121 | -5157 |
| Naglu | 4598 | 2203 |
| Sdc1 | 7061 | 4784 |
| Sdc2 | 7435 | 6631 |
| Sdc3 | 4012 | 3827 |
| Sdc4 | 4355 | -9 |
| Sgsh | 6079 | 5115 |
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.00953 |
| p.adjustMANOVA | 0.0497 |
| s.dist | 0.162 |
| s.young | 0.0955 |
| s.old | -0.131 |
| p.young | 0.428 |
| p.old | 0.277 |
| Gene | young | old |
|---|---|---|
| Smad3 | 3925 | -4081 |
| Trim63 | 3120 | -2972 |
| Nr3c1 | 2927 | -1142 |
| Smad2 | 2945 | -931 |
| Foxo1 | 2248 | -1056 |
| Sin3a | 625 | -2529 |
| Fbxo32 | 2078 | -742 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abca6 | 6893 | 4821 |
| Atxn3 | 1750 | 2527 |
| Cat | -2626 | -1549 |
| Fbxo32 | 2078 | -742 |
| Foxo1 | 2248 | -1056 |
| Foxo3 | -3836 | -5969 |
| Foxo4 | -4257 | -3546 |
| Foxo6 | -2013 | -6019 |
| Gck | 6897 | 4422 |
| Hdac1 | 5275 | 3944 |
| Hdac2 | -4789 | -5887 |
| Nr3c1 | 2927 | -1142 |
| Pck1 | 1338 | 425 |
| Plxna4 | 5182 | 3976 |
| Ppargc1a | -6363 | -7511 |
| Sin3a | 625 | -2529 |
| Sirt3 | -6560 | -6988 |
| Smad2 | 2945 | -931 |
| Smad3 | 3925 | -4081 |
| Smad4 | 4924 | 4471 |
| Sod2 | -7345 | -7817 |
| Srebf1 | 5979 | 2962 |
| Trim63 | 3120 | -2972 |
Sialic-acid-metabolism
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 0.00327 |
| p.adjustMANOVA | 0.0207 |
| s.dist | 0.239 |
| s.young | 0.238 |
| s.old | 0.0168 |
| p.young | 0.0355 |
| p.old | 0.882 |
| Gene | young | old |
|---|---|---|
| St8sia1 | 6367 | 6714 |
| St3gal2 | 6995 | 5852 |
| St6galnac4 | 6331 | 6062 |
| Nans | 6392 | 4932 |
| St8sia2 | 4491 | 4888 |
| St3gal5 | 5507 | 3409 |
| Slc17a5 | 4456 | 2342 |
| Glb1 | 5822 | 1047 |
| Nanp | 2835 | 1684 |
| Npl | 2978 | 1243 |
| Cmas | 3263 | 831 |
| St3gal1 | 3058 | 716 |
| Ctsa | 3546 | 448 |
| Slc35a1 | 4230 | 111 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cmas | 3263 | 831 |
| Ctsa | 3546 | 448 |
| Glb1 | 5822 | 1047 |
| Gne | 1172 | -1633 |
| Nanp | 2835 | 1684 |
| Nans | 6392 | 4932 |
| Neu1 | -4503 | -122 |
| Neu3 | -2654 | -2701 |
| Npl | 2978 | 1243 |
| Slc17a5 | 4456 | 2342 |
| Slc35a1 | 4230 | 111 |
| St3gal1 | 3058 | 716 |
| St3gal2 | 6995 | 5852 |
| St3gal3 | -6777 | -6624 |
| St3gal4 | 4466 | -4957 |
| St3gal5 | 5507 | 3409 |
| St3gal6 | -4673 | -4593 |
| St6gal1 | 4351 | -2022 |
| St6galnac2 | 5684 | -2059 |
| St6galnac3 | 48 | -5018 |
| St6galnac4 | 6331 | 6062 |
| St6galnac6 | -7184 | -7584 |
| St8sia1 | 6367 | 6714 |
| St8sia2 | 4491 | 4888 |
| St8sia4 | -6404 | -5155 |
| St8sia6 | -1521 | -4549 |
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.00601 |
| p.adjustMANOVA | 0.0347 |
| s.dist | 0.25 |
| s.young | 0.248 |
| s.old | 0.028 |
| p.young | 0.0395 |
| p.old | 0.817 |
| Gene | young | old |
|---|---|---|
| Skil | 7055 | 6612 |
| Tgif1 | 6842 | 6437 |
| Ski | 5082 | 5289 |
| Smurf2 | 5768 | 4293 |
| Ube2d3 | 5709 | 3978 |
| Smad4 | 4924 | 4471 |
| Hdac1 | 5275 | 3944 |
| Ncor2 | 4764 | 3742 |
| Tgif2 | 4702 | 866 |
| Trim33 | 3450 | 122 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Gm11808 | -5706 | -216 |
| Hdac1 | 5275 | 3944 |
| Ncor1 | -4730 | -6152 |
| Ncor2 | 4764 | 3742 |
| Nedd4l | -4561 | -6654 |
| Parp1 | -6470 | -6763 |
| Ppm1a | 2517 | -2532 |
| Rnf111 | 268 | -2449 |
| Rps27a | -1504 | -1029 |
| Ski | 5082 | 5289 |
| Skil | 7055 | 6612 |
| Smad2 | 2945 | -931 |
| Smad3 | 3925 | -4081 |
| Smad4 | 4924 | 4471 |
| Smurf2 | 5768 | 4293 |
| Tgif1 | 6842 | 6437 |
| Tgif2 | 4702 | 866 |
| Trim33 | 3450 | 122 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Ube2d1 | -4576 | -5721 |
| Ube2d3 | 5709 | 3978 |
| Usp9x | 4374 | -3676 |
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 0.00325 |
| p.adjustMANOVA | 0.0207 |
| s.dist | 0.225 |
| s.young | -0.0147 |
| s.old | -0.225 |
| p.young | 0.891 |
| p.old | 0.0362 |
| Gene | young | old |
|---|---|---|
| Ube2b | -6925 | -7329 |
| Cdc34 | -7020 | -6823 |
| Ube2r2 | -6384 | -6380 |
| Ube2a | -5301 | -5570 |
| Ube2d1 | -4576 | -5721 |
| Ube2e3 | -3833 | -6596 |
| Uchl3 | -4443 | -5303 |
| Ube2k | -2821 | -4679 |
| Usp5 | -2839 | -2731 |
| Ube2t | -2298 | -1230 |
| Ube2d2a | -681 | -3716 |
| Ubc | -1436 | -1699 |
| Rps27a | -1504 | -1029 |
| Ube2s | -1064 | -1454 |
| Gm11808 | -5706 | -216 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc34 | -7020 | -6823 |
| Gm11808 | -5706 | -216 |
| Otulin | 7371 | 6868 |
| Rps27a | -1504 | -1029 |
| Uba1 | 3207 | -97 |
| Uba6 | 4311 | -2236 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Ube2a | -5301 | -5570 |
| Ube2b | -6925 | -7329 |
| Ube2c | 5815 | 4785 |
| Ube2d1 | -4576 | -5721 |
| Ube2d2a | -681 | -3716 |
| Ube2e1 | 3650 | -762 |
| Ube2e3 | -3833 | -6596 |
| Ube2g1 | 2479 | -2994 |
| Ube2g2 | 973 | 476 |
| Ube2h | 4381 | -1749 |
| Ube2k | -2821 | -4679 |
| Ube2q2 | 4037 | -886 |
| Ube2r2 | -6384 | -6380 |
| Ube2s | -1064 | -1454 |
| Ube2t | -2298 | -1230 |
| Ube2w | 2917 | 1334 |
| Ube2z | 5974 | 2915 |
| Uchl3 | -4443 | -5303 |
| Usp5 | -2839 | -2731 |
| Usp7 | 931 | -1139 |
| Usp9x | 4374 | -3676 |
Triglyceride-catabolism
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 9.29e-06 |
| p.adjustMANOVA | 0.000175 |
| s.dist | 0.868 |
| s.young | -0.503 |
| s.old | -0.708 |
| p.young | 0.000741 |
| p.old | 2.07e-06 |
| Gene | young | old |
|---|---|---|
| Plin3 | -6858 | -7441 |
| Cav1 | -5892 | -7143 |
| Ppp1cb | -6139 | -5952 |
| Prkaca | -6075 | -5990 |
| Fabp3 | -5416 | -6575 |
| Abhd5 | -5259 | -6321 |
| Mgll | -4506 | -7118 |
| Gpd2 | -5217 | -5433 |
| Lipe | -4226 | -5925 |
| Ppp1cc | -3515 | -5893 |
| Fabp4 | -2511 | -7146 |
| Ppp1ca | -2389 | -1250 |
| Fabp5 | -285 | -5130 |
| Plin1 | -369 | -3417 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abhd5 | -5259 | -6321 |
| Cav1 | -5892 | -7143 |
| Fabp3 | -5416 | -6575 |
| Fabp4 | -2511 | -7146 |
| Fabp5 | -285 | -5130 |
| Gpd2 | -5217 | -5433 |
| Lipe | -4226 | -5925 |
| Mgll | -4506 | -7118 |
| Plin1 | -369 | -3417 |
| Plin3 | -6858 | -7441 |
| Ppp1ca | -2389 | -1250 |
| Ppp1cb | -6139 | -5952 |
| Ppp1cc | -3515 | -5893 |
| Prkaca | -6075 | -5990 |
| Prkacb | 3875 | -3919 |
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 2.72e-05 |
| p.adjustMANOVA | 0.00043 |
| s.dist | 0.339 |
| s.young | -0.315 |
| s.old | -0.127 |
| p.young | 0.000164 |
| p.old | 0.129 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc25a | 1914 | -3410 |
| Chek1 | 1067 | 3898 |
| Chek2 | -5785 | -1283 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
p53-Independent-DNA-Damage-Response
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 2.72e-05 |
| p.adjustMANOVA | 0.00043 |
| s.dist | 0.339 |
| s.young | -0.315 |
| s.old | -0.127 |
| p.young | 0.000164 |
| p.old | 0.129 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc25a | 1914 | -3410 |
| Chek1 | 1067 | 3898 |
| Chek2 | -5785 | -1283 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
p53-Independent-G1/S-DNA-damage-checkpoint
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 2.72e-05 |
| p.adjustMANOVA | 0.00043 |
| s.dist | 0.339 |
| s.young | -0.315 |
| s.old | -0.127 |
| p.young | 0.000164 |
| p.old | 0.129 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc25a | 1914 | -3410 |
| Chek1 | 1067 | 3898 |
| Chek2 | -5785 | -1283 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Assembly-of-the-pre-replicative-complex
| metric | value |
|---|---|
| setSize | 64 |
| pMANOVA | 6.67e-05 |
| p.adjustMANOVA | 0.000917 |
| s.dist | 0.186 |
| s.young | -0.186 |
| s.old | -0.000335 |
| p.young | 0.00999 |
| p.old | 0.996 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Gmnn | -6348 | -7684 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Mcm8 | -4545 | -5868 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc6 | 558 | 3310 |
| Cdt1 | 3752 | 3214 |
| E2f1 | 4237 | 5630 |
| E2f2 | 1676 | 923 |
| E2f3 | 6585 | 6156 |
| Gm11808 | -5706 | -216 |
| Gmnn | -6348 | -7684 |
| Mcm2 | 991 | 5847 |
| Mcm3 | 4423 | 5175 |
| Mcm4 | 5354 | 4383 |
| Mcm5 | 3540 | 5617 |
| Mcm6 | 5546 | 6648 |
| Mcm7 | 647 | 5992 |
| Mcm8 | -4545 | -5868 |
| Orc1 | 2018 | 3208 |
| Orc2 | -52 | 3709 |
| Orc3 | -2266 | -4705 |
| Orc4 | -1216 | -1538 |
| Orc5 | -3013 | -3379 |
| Orc6 | 311 | 1397 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Regulation-of-ornithine-decarboxylase-(ODC)
| metric | value |
|---|---|
| setSize | 46 |
| pMANOVA | 3.97e-05 |
| p.adjustMANOVA | 0.000596 |
| s.dist | 0.347 |
| s.young | -0.32 |
| s.old | -0.135 |
| p.young | 0.000173 |
| p.old | 0.113 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Oaz1 | -6430 | -4907 |
| Psme4 | -5860 | -5252 |
| Oaz2 | -6186 | -4745 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Nqo1 | -3232 | -6640 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Azin1 | 7005 | 6713 |
| Nqo1 | -3232 | -6640 |
| Oaz1 | -6430 | -4907 |
| Oaz2 | -6186 | -4745 |
| Odc1 | 5704 | 3746 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
Autodegradation-of-the-E3-ubiquitin-ligase-COP1
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 7.41e-05 |
| p.adjustMANOVA | 0.000977 |
| s.dist | 0.315 |
| s.young | -0.295 |
| s.old | -0.11 |
| p.young | 0.000469 |
| p.old | 0.192 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Atm | 1253 | 1499 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Trp53 | 4978 | 4881 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Heparan-sulfate/heparin-(HS-GAG)-metabolism
| metric | value |
|---|---|
| setSize | 42 |
| pMANOVA | 1.75e-07 |
| p.adjustMANOVA | 4.23e-06 |
| s.dist | 0.551 |
| s.young | 0.471 |
| s.old | 0.287 |
| p.young | 1.31e-07 |
| p.old | 0.00131 |
| Gene | young | old |
|---|---|---|
| Bgn | 7481 | 6830 |
| Cspg4 | 7500 | 6779 |
| Dcn | 7414 | 6701 |
| Sdc2 | 7435 | 6631 |
| Vcan | 7188 | 6694 |
| Hs2st1 | 7325 | 6476 |
| Ext1 | 6621 | 6756 |
| Gpc6 | 6891 | 6273 |
| Slc35d2 | 6737 | 5737 |
| Xylt1 | 6328 | 6030 |
| Sdc1 | 7061 | 4784 |
| Hs6st1 | 6013 | 5322 |
| Ids | 6784 | 4640 |
| Sgsh | 6079 | 5115 |
| Hs3st3a1 | 6472 | 4761 |
| Gusb | 6165 | 4930 |
| Glb1l | 5086 | 5055 |
| Hspg2 | 6535 | 3769 |
| Sdc3 | 4012 | 3827 |
| B3galt6 | 4154 | 3582 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Agrn | -247 | 199 |
| B3galt6 | 4154 | 3582 |
| B3gat2 | 2242 | 2141 |
| B3gat3 | -677 | -1460 |
| B4galt7 | -1177 | -3787 |
| Bgn | 7481 | 6830 |
| Cspg4 | 7500 | 6779 |
| Cspg5 | -3048 | 1942 |
| Dcn | 7414 | 6701 |
| Ext1 | 6621 | 6756 |
| Ext2 | 1986 | -1619 |
| Glb1 | 5822 | 1047 |
| Glb1l | 5086 | 5055 |
| Glce | 179 | -4014 |
| Gpc1 | -3801 | -4293 |
| Gpc3 | 2127 | -5769 |
| Gpc4 | -3619 | -6582 |
| Gpc6 | 6891 | 6273 |
| Gusb | 6165 | 4930 |
| Hpse | 4346 | -2233 |
| Hs2st1 | 7325 | 6476 |
| Hs3st1 | -493 | -13 |
| Hs3st3a1 | 6472 | 4761 |
| Hs3st3b1 | 1722 | -4410 |
| Hs6st1 | 6013 | 5322 |
| Hs6st2 | 2526 | -4992 |
| Hspg2 | 6535 | 3769 |
| Ids | 6784 | 4640 |
| Idua | -5121 | -5157 |
| Naglu | 4598 | 2203 |
| Ndst1 | -1729 | -4940 |
| Ndst2 | 4415 | 2740 |
| Ndst3 | 3651 | 3254 |
| Sdc1 | 7061 | 4784 |
| Sdc2 | 7435 | 6631 |
| Sdc3 | 4012 | 3827 |
| Sdc4 | 4355 | -9 |
| Sgsh | 6079 | 5115 |
| Slc35d2 | 6737 | 5737 |
| Vcan | 7188 | 6694 |
| Xylt1 | 6328 | 6030 |
| Xylt2 | 2935 | -1769 |
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT)
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 0.00764 |
| p.adjustMANOVA | 0.042 |
| s.dist | 0.229 |
| s.young | 0.225 |
| s.old | 0.0412 |
| p.young | 0.0328 |
| p.old | 0.696 |
| Gene | young | old |
|---|---|---|
| Chmp3 | 6948 | 5512 |
| Chmp4c | 6803 | 4718 |
| Vps37c | 6840 | 4593 |
| Vps37b | 5108 | 4515 |
| Hgs | 4975 | 3859 |
| Chmp7 | 3831 | 4757 |
| Stam2 | 5387 | 2587 |
| Vps37d | 4303 | 2352 |
| Chmp4b | 5717 | 1200 |
| Vps4b | 4244 | 959 |
| Chmp5 | 3696 | 136 |
| Ubap1 | 28 | 767 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Chmp2a | 1793 | -1096 |
| Chmp2b | 1232 | -1104 |
| Chmp3 | 6948 | 5512 |
| Chmp4b | 5717 | 1200 |
| Chmp4c | 6803 | 4718 |
| Chmp5 | 3696 | 136 |
| Chmp6 | 1760 | -423 |
| Chmp7 | 3831 | 4757 |
| Gm11808 | -5706 | -216 |
| Hgs | 4975 | 3859 |
| Mvb12a | -4581 | -3590 |
| Mvb12b | 2144 | -1272 |
| Rps27a | -1504 | -1029 |
| Snf8 | 2394 | -1547 |
| Stam | 1544 | -52 |
| Stam2 | 5387 | 2587 |
| Tsg101 | -1470 | -2662 |
| Ubap1 | 28 | 767 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Vps25 | 1921 | -2808 |
| Vps28 | -262 | -2609 |
| Vps36 | -1041 | -4966 |
| Vps37a | -1385 | -3737 |
| Vps37b | 5108 | 4515 |
| Vps37c | 6840 | 4593 |
| Vps37d | 4303 | 2352 |
| Vps4a | -6836 | -7286 |
| Vps4b | 4244 | 959 |
| Vta1 | 547 | -286 |
Post-NMDA-receptor-activation-events
| metric | value |
|---|---|
| setSize | 50 |
| pMANOVA | 0.00131 |
| p.adjustMANOVA | 0.00994 |
| s.dist | 0.136 |
| s.young | 0.122 |
| s.old | -0.0609 |
| p.young | 0.136 |
| p.old | 0.456 |
| Gene | young | old |
|---|---|---|
| Rps6ka2 | 5542 | -5598 |
| Prkacb | 3875 | -3919 |
| Nrgn | 3292 | -2826 |
| Prkag2 | 4029 | -2192 |
| Grin2c | 791 | -5559 |
| Arhgef7 | 863 | -4668 |
| Grin2d | 5624 | -588 |
| Dlg1 | 1311 | -1704 |
| Mapk3 | 1686 | -900 |
| Rac1 | 328 | -2928 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Actn2 | -2000 | -1053 |
| Adcy1 | -6563 | -7364 |
| Arhgef7 | 863 | -4668 |
| Calm1 | -4595 | -4970 |
| Camk1 | 5843 | 3939 |
| Camk2a | -6445 | -7293 |
| Camk2b | 7071 | 5898 |
| Camk2g | -3829 | -6080 |
| Camkk1 | 6373 | 6639 |
| Camkk2 | 6852 | 5301 |
| Creb1 | -3517 | -2558 |
| Dlg1 | 1311 | -1704 |
| Dlg2 | 7058 | 6995 |
| Dlg3 | 4869 | 4306 |
| Dlg4 | 6131 | 5964 |
| Erbb4 | -4933 | -5991 |
| Git1 | -110 | -1741 |
| Gria2 | -268 | -1375 |
| Grin2c | 791 | -5559 |
| Grin2d | 5624 | -588 |
| Hras | -3767 | -1016 |
| Kpna2 | -4477 | -5690 |
| Kras | -2032 | -4043 |
| Mapk1 | -4365 | -6214 |
| Mapk3 | 1686 | -900 |
| Mapt | -4280 | -1351 |
| Nras | 4487 | 1253 |
| Nrg1 | 6778 | 5305 |
| Nrgn | 3292 | -2826 |
| Pdpk1 | 3688 | 3414 |
| Prkaa1 | 3612 | 3708 |
| Prkaa2 | -6100 | -7414 |
| Prkab1 | -4034 | -7255 |
| Prkab2 | 7420 | 5930 |
| Prkaca | -6075 | -5990 |
| Prkacb | 3875 | -3919 |
| Prkag1 | -6213 | -4030 |
| Prkag2 | 4029 | -2192 |
| Prkag3 | 5303 | 4957 |
| Prkar1a | 6142 | 4210 |
| Prkar1b | 1256 | 1039 |
| Prkar2a | -4064 | -4969 |
| Prkar2b | 3433 | 313 |
| Prkx | 3534 | 1608 |
| Rac1 | 328 | -2928 |
| Rasgrf2 | -3199 | -6106 |
| Rps6ka1 | 4173 | 287 |
| Rps6ka2 | 5542 | -5598 |
| Rps6ka3 | 1822 | 3743 |
| Src | 7196 | 6795 |
RAB-geranylgeranylation
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 0.001 |
| p.adjustMANOVA | 0.00801 |
| s.dist | 0.148 |
| s.young | 0.142 |
| s.old | -0.041 |
| p.young | 0.0801 |
| p.old | 0.613 |
| Gene | young | old |
|---|---|---|
| Rab40b | 6127 | -3597 |
| Ptp4a2 | 2596 | -3793 |
| Rab40c | 1260 | -3488 |
| Rab11b | 1212 | -3386 |
| Rab2a | 2739 | -1349 |
| Rab5c | 3142 | -1160 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Chm | 4576 | 910 |
| Chml | 4934 | 6307 |
| Ptp4a2 | 2596 | -3793 |
| Rab10 | -4439 | -5212 |
| Rab11a | -2501 | -5885 |
| Rab11b | 1212 | -3386 |
| Rab12 | -5280 | -6895 |
| Rab13 | 6900 | 6349 |
| Rab14 | -5276 | -6634 |
| Rab15 | 7415 | 6757 |
| Rab17 | -6502 | -6310 |
| Rab18 | -1250 | -4021 |
| Rab1a | -3223 | -6062 |
| Rab1b | -6030 | -5486 |
| Rab20 | -1334 | -2750 |
| Rab21 | -4812 | -6186 |
| Rab22a | -2394 | -3903 |
| Rab23 | 5397 | 5291 |
| Rab24 | -4445 | -4221 |
| Rab27a | -1179 | -3721 |
| Rab27b | 7417 | 6961 |
| Rab29 | 3606 | 2590 |
| Rab2a | 2739 | -1349 |
| Rab2b | 5649 | 2106 |
| Rab30 | -3630 | -2354 |
| Rab31 | 7227 | 6762 |
| Rab33b | 6021 | 3134 |
| Rab34 | 6739 | 5997 |
| Rab35 | 5336 | 845 |
| Rab36 | 4621 | 4563 |
| Rab37 | -508 | -4370 |
| Rab3a | -6304 | -4824 |
| Rab3d | 4802 | 2649 |
| Rab40b | 6127 | -3597 |
| Rab40c | 1260 | -3488 |
| Rab42 | -3188 | -3257 |
| Rab43 | 4039 | 2459 |
| Rab4a | 1717 | 2240 |
| Rab4b | 6975 | 6460 |
| Rab5a | 5098 | 86 |
| Rab5b | -1911 | -4750 |
| Rab5c | 3142 | -1160 |
| Rab6a | 6083 | 2806 |
| Rab6b | 4327 | 1836 |
| Rab7 | -5369 | -6377 |
| Rab7b | 6565 | 5190 |
| Rab8a | 1372 | 1357 |
| Rab8b | 4850 | 2440 |
| Rab9 | -2739 | -6338 |
| Rabggta | -4972 | -3450 |
| Rabggtb | -3434 | -1391 |
DNA-Replication-Pre-Initiation
| metric | value |
|---|---|
| setSize | 80 |
| pMANOVA | 2.28e-05 |
| p.adjustMANOVA | 0.000389 |
| s.dist | 0.146 |
| s.young | -0.139 |
| s.old | 0.0426 |
| p.young | 0.0315 |
| p.old | 0.51 |
| Gene | young | old |
|---|---|---|
| Psmd7 | -3344 | 2462 |
| Rpa2 | -4464 | 1119 |
| Pola1 | -1035 | 1098 |
| Psmd4 | -73 | 2814 |
| Orc2 | -52 | 3709 |
| Psmc6 | -3319 | 55 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc45 | 1307 | 4267 |
| Cdc6 | 558 | 3310 |
| Cdc7 | 3322 | 3112 |
| Cdk2 | -2220 | -2606 |
| Cdt1 | 3752 | 3214 |
| Dbf4 | 1985 | 693 |
| E2f1 | 4237 | 5630 |
| E2f2 | 1676 | 923 |
| E2f3 | 6585 | 6156 |
| Gm11808 | -5706 | -216 |
| Gmnn | -6348 | -7684 |
| Mcm10 | 566 | 3908 |
| Mcm2 | 991 | 5847 |
| Mcm3 | 4423 | 5175 |
| Mcm4 | 5354 | 4383 |
| Mcm5 | 3540 | 5617 |
| Mcm6 | 5546 | 6648 |
| Mcm7 | 647 | 5992 |
| Mcm8 | -4545 | -5868 |
| Orc1 | 2018 | 3208 |
| Orc2 | -52 | 3709 |
| Orc3 | -2266 | -4705 |
| Orc4 | -1216 | -1538 |
| Orc5 | -3013 | -3379 |
| Orc6 | 311 | 1397 |
| Pola1 | -1035 | 1098 |
| Pola2 | 6434 | 6486 |
| Pole | 737 | 887 |
| Pole2 | 2779 | 862 |
| Pole3 | 4352 | 2906 |
| Pole4 | -2199 | -1885 |
| Prim1 | 2676 | 3372 |
| Prim2 | 1992 | 3007 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rpa1 | -4117 | -3049 |
| Rpa2 | -4464 | 1119 |
| Rpa3 | -4808 | -4927 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Stabilization-of-p53
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 7.5e-05 |
| p.adjustMANOVA | 0.000979 |
| s.dist | 0.291 |
| s.young | -0.276 |
| s.old | -0.094 |
| p.young | 0.000662 |
| p.old | 0.246 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Atm | 1253 | 1499 |
| Chek2 | -5785 | -1283 |
| Gm11808 | -5706 | -216 |
| Mdm2 | 4383 | 4102 |
| Mdm4 | -4108 | -221 |
| Phf20 | 4433 | -1340 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Trp53 | 4978 | 4881 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Smooth-Muscle-Contraction
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 0.00921 |
| p.adjustMANOVA | 0.0483 |
| s.dist | 0.213 |
| s.young | 0.0314 |
| s.old | 0.211 |
| p.young | 0.762 |
| p.old | 0.0421 |
| Gene | young | old |
|---|---|---|
| Tpm2 | 7506 | 6955 |
| Anxa2 | 6945 | 6847 |
| Anxa1 | 7137 | 6423 |
| Itgb5 | 7035 | 6117 |
| Tln1 | 6888 | 5990 |
| Sorbs3 | 5997 | 6450 |
| Cald1 | 6283 | 5671 |
| Myl12a | 5669 | 5304 |
| Anxa6 | 5722 | 2604 |
| Pak1 | 3769 | 3862 |
| Tpm3 | 3419 | 4092 |
| Dysf | 1616 | 5692 |
| Myl6b | 569 | 5006 |
| Vcl | 879 | 1982 |
| Myl12b | 844 | 518 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acta2 | -5838 | 3002 |
| Actg2 | -2377 | -637 |
| Anxa1 | 7137 | 6423 |
| Anxa2 | 6945 | 6847 |
| Anxa6 | 5722 | 2604 |
| Cald1 | 6283 | 5671 |
| Calm1 | -4595 | -4970 |
| Cav3 | -6028 | -3293 |
| Dysf | 1616 | 5692 |
| Gucy1a2 | -2952 | -4419 |
| Itga1 | -2422 | -3850 |
| Itgb5 | 7035 | 6117 |
| Lmod1 | -1775 | 2083 |
| Myh11 | -4929 | -1359 |
| Myl12a | 5669 | 5304 |
| Myl12b | 844 | 518 |
| Myl6b | 569 | 5006 |
| Myl7 | -4553 | 1587 |
| Myl9 | -1361 | -776 |
| Mylk | -6527 | -5002 |
| Pak1 | 3769 | 3862 |
| Pak2 | 1636 | -1595 |
| Pxn | -1407 | -2587 |
| Sorbs1 | -5262 | -5248 |
| Sorbs3 | 5997 | 6450 |
| Tln1 | 6888 | 5990 |
| Tpm1 | -6913 | -5352 |
| Tpm2 | 7506 | 6955 |
| Tpm3 | 3419 | 4092 |
| Trim72 | -5043 | -4443 |
| Vcl | 879 | 1982 |
Activation-of-the-pre-replicative-complex
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 0.00528 |
| p.adjustMANOVA | 0.0318 |
| s.dist | 0.247 |
| s.young | 0.0599 |
| s.old | 0.239 |
| p.young | 0.558 |
| p.old | 0.0191 |
| Gene | young | old |
|---|---|---|
| Pola2 | 6434 | 6486 |
| Mcm6 | 5546 | 6648 |
| Mcm4 | 5354 | 4383 |
| Mcm3 | 4423 | 5175 |
| Mcm5 | 3540 | 5617 |
| Pole3 | 4352 | 2906 |
| Cdt1 | 3752 | 3214 |
| Cdc7 | 3322 | 3112 |
| Prim1 | 2676 | 3372 |
| Orc1 | 2018 | 3208 |
| Prim2 | 1992 | 3007 |
| Mcm2 | 991 | 5847 |
| Cdc45 | 1307 | 4267 |
| Mcm7 | 647 | 5992 |
| Pole2 | 2779 | 862 |
| Mcm10 | 566 | 3908 |
| Cdc6 | 558 | 3310 |
| Dbf4 | 1985 | 693 |
| Pole | 737 | 887 |
| Orc6 | 311 | 1397 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc45 | 1307 | 4267 |
| Cdc6 | 558 | 3310 |
| Cdc7 | 3322 | 3112 |
| Cdk2 | -2220 | -2606 |
| Cdt1 | 3752 | 3214 |
| Dbf4 | 1985 | 693 |
| Gmnn | -6348 | -7684 |
| Mcm10 | 566 | 3908 |
| Mcm2 | 991 | 5847 |
| Mcm3 | 4423 | 5175 |
| Mcm4 | 5354 | 4383 |
| Mcm5 | 3540 | 5617 |
| Mcm6 | 5546 | 6648 |
| Mcm7 | 647 | 5992 |
| Mcm8 | -4545 | -5868 |
| Orc1 | 2018 | 3208 |
| Orc2 | -52 | 3709 |
| Orc3 | -2266 | -4705 |
| Orc4 | -1216 | -1538 |
| Orc5 | -3013 | -3379 |
| Orc6 | 311 | 1397 |
| Pola1 | -1035 | 1098 |
| Pola2 | 6434 | 6486 |
| Pole | 737 | 887 |
| Pole2 | 2779 | 862 |
| Pole3 | 4352 | 2906 |
| Pole4 | -2199 | -1885 |
| Prim1 | 2676 | 3372 |
| Prim2 | 1992 | 3007 |
| Rpa1 | -4117 | -3049 |
| Rpa2 | -4464 | 1119 |
| Rpa3 | -4808 | -4927 |
Ubiquitin-dependent-degradation-of-Cyclin-D
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 0.000172 |
| p.adjustMANOVA | 0.0019 |
| s.dist | 0.288 |
| s.young | -0.272 |
| s.old | -0.0936 |
| p.young | 0.00111 |
| p.old | 0.262 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ccnd1 | 2065 | 4489 |
| Cdk4 | 3801 | 980 |
| Gm11808 | -5706 | -216 |
| Gsk3b | 6419 | 5572 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation
| metric | value |
|---|---|
| setSize | 46 |
| pMANOVA | 6.86e-05 |
| p.adjustMANOVA | 0.000933 |
| s.dist | 0.343 |
| s.young | -0.315 |
| s.old | -0.137 |
| p.young | 0.000224 |
| p.old | 0.108 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Gm11808 | -5706 | -216 |
| Pak2 | 1636 | -1595 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Protein-ubiquitination
| metric | value |
|---|---|
| setSize | 62 |
| pMANOVA | 0.000331 |
| p.adjustMANOVA | 0.00324 |
| s.dist | 0.156 |
| s.young | 0.0222 |
| s.old | -0.154 |
| p.young | 0.762 |
| p.old | 0.036 |
| Gene | young | old |
|---|---|---|
| Usp9x | 4374 | -3676 |
| Ubb | 5763 | -1908 |
| Pex12 | 2346 | -4157 |
| Uba6 | 4311 | -2236 |
| Ube2h | 4381 | -1749 |
| Ube2g1 | 2479 | -2994 |
| Rraga | 2409 | -2434 |
| Derl1 | 1222 | -3922 |
| Ube2q2 | 4037 | -886 |
| Ube2e1 | 3650 | -762 |
| Ube2v2 | 3853 | -647 |
| Pex14 | 809 | -2777 |
| Rnf20 | 1561 | -903 |
| Usp7 | 931 | -1139 |
| Uba1 | 3207 | -97 |
| Cdc73 | 61 | -1350 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Bcl10 | 3503 | 933 |
| Cdc34 | -7020 | -6823 |
| Cdc73 | 61 | -1350 |
| Ctr9 | -2675 | -4126 |
| Derl1 | 1222 | -3922 |
| Gm11808 | -5706 | -216 |
| Hltf | 2357 | 2874 |
| Leo1 | -296 | -4202 |
| Otulin | 7371 | 6868 |
| Paf1 | 876 | 1604 |
| Pcna | -491 | 3253 |
| Pex10 | -6076 | -6073 |
| Pex12 | 2346 | -4157 |
| Pex13 | -771 | -5620 |
| Pex14 | 809 | -2777 |
| Pex2 | -5398 | -6265 |
| Pex5 | 5993 | 2191 |
| Prkdc | 4840 | 6764 |
| Rad18 | 5613 | 6072 |
| Rnf144a | -559 | -5331 |
| Rnf152 | -1671 | -1422 |
| Rnf181 | 3668 | 3650 |
| Rnf20 | 1561 | -903 |
| Rnf40 | -2967 | 501 |
| Rps27a | -1504 | -1029 |
| Rraga | 2409 | -2434 |
| Rtf1 | -3806 | -6273 |
| Selenos | 6071 | 698 |
| Shprh | 309 | 2000 |
| Tmem129 | -1574 | -1433 |
| Uba1 | 3207 | -97 |
| Uba6 | 4311 | -2236 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Ube2a | -5301 | -5570 |
| Ube2b | -6925 | -7329 |
| Ube2c | 5815 | 4785 |
| Ube2d1 | -4576 | -5721 |
| Ube2d2a | -681 | -3716 |
| Ube2d3 | 5709 | 3978 |
| Ube2e1 | 3650 | -762 |
| Ube2e3 | -3833 | -6596 |
| Ube2g1 | 2479 | -2994 |
| Ube2g2 | 973 | 476 |
| Ube2h | 4381 | -1749 |
| Ube2j2 | -2625 | -2495 |
| Ube2k | -2821 | -4679 |
| Ube2n | -5254 | -5400 |
| Ube2q2 | 4037 | -886 |
| Ube2r2 | -6384 | -6380 |
| Ube2s | -1064 | -1454 |
| Ube2t | -2298 | -1230 |
| Ube2v2 | 3853 | -647 |
| Ube2w | 2917 | 1334 |
| Ube2z | 5974 | 2915 |
| Uchl3 | -4443 | -5303 |
| Usp5 | -2839 | -2731 |
| Usp7 | 931 | -1139 |
| Usp9x | 4374 | -3676 |
| Vcp | -2921 | -3485 |
| Wac | -15 | -2599 |
| Wdr61 | 2151 | 1382 |
TNFs-bind-their-physiological-receptors
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00681 |
| p.adjustMANOVA | 0.0384 |
| s.dist | 0.609 |
| s.young | 0.334 |
| s.old | 0.509 |
| p.young | 0.0452 |
| p.old | 0.00225 |
| Gene | young | old |
|---|---|---|
| Edar | 7207 | 6941 |
| Eda2r | 6802 | 6567 |
| Tnfrsf11b | 5902 | 6329 |
| Eda | 5779 | 5013 |
| Tnfrsf1a | 5169 | 3989 |
| Tnfrsf1b | 3982 | 4136 |
| Tnfrsf18 | 1551 | 2263 |
| Tnfsf13b | 435 | 2212 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Eda | 5779 | 5013 |
| Eda2r | 6802 | 6567 |
| Edar | 7207 | 6941 |
| Tnfrsf11b | 5902 | 6329 |
| Tnfrsf13b | -660 | 551 |
| Tnfrsf14 | -809 | 3256 |
| Tnfrsf18 | 1551 | 2263 |
| Tnfrsf1a | 5169 | 3989 |
| Tnfrsf1b | 3982 | 4136 |
| Tnfrsf25 | -4904 | 1074 |
| Tnfsf13 | 373 | -1507 |
| Tnfsf13b | 435 | 2212 |
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA
| metric | value |
|---|---|
| setSize | 50 |
| pMANOVA | 9.96e-05 |
| p.adjustMANOVA | 0.00122 |
| s.dist | 0.308 |
| s.young | -0.286 |
| s.old | -0.113 |
| p.young | 0.000463 |
| p.old | 0.168 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Eif4g1 | -5508 | -5906 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Hspa8 | -5126 | -2542 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Eif4g1 | -5508 | -5906 |
| Gm11808 | -5706 | -216 |
| Hnrnpd | 2404 | -1526 |
| Hspa1b | 3948 | 4977 |
| Hspa8 | -5126 | -2542 |
| Hspb1 | 7446 | 6787 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Orc1-removal-from-chromatin
| metric | value |
|---|---|
| setSize | 66 |
| pMANOVA | 9.92e-05 |
| p.adjustMANOVA | 0.00122 |
| s.dist | 0.203 |
| s.young | -0.201 |
| s.old | -0.0276 |
| p.young | 0.00476 |
| p.old | 0.698 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Mcm8 | -4545 | -5868 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Rbx1 | -4743 | -4554 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Skp1a | -2255 | -5461 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ccna2 | 5229 | 5333 |
| Cdc6 | 558 | 3310 |
| Cdk2 | -2220 | -2606 |
| Cdt1 | 3752 | 3214 |
| Cul1 | -3119 | -3855 |
| Gm11808 | -5706 | -216 |
| Mcm2 | 991 | 5847 |
| Mcm3 | 4423 | 5175 |
| Mcm4 | 5354 | 4383 |
| Mcm5 | 3540 | 5617 |
| Mcm6 | 5546 | 6648 |
| Mcm7 | 647 | 5992 |
| Mcm8 | -4545 | -5868 |
| Orc1 | 2018 | 3208 |
| Orc2 | -52 | 3709 |
| Orc3 | -2266 | -4705 |
| Orc4 | -1216 | -1538 |
| Orc5 | -3013 | -3379 |
| Orc6 | 311 | 1397 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rbx1 | -4743 | -4554 |
| Rps27a | -1504 | -1029 |
| Skp1a | -2255 | -5461 |
| Skp2 | 3484 | 2048 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
CDT1-association-with-the-CDC6:ORC:origin-complex
| metric | value |
|---|---|
| setSize | 55 |
| pMANOVA | 2.89e-05 |
| p.adjustMANOVA | 0.000451 |
| s.dist | 0.32 |
| s.young | -0.296 |
| s.old | -0.123 |
| p.young | 0.000149 |
| p.old | 0.116 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Gmnn | -6348 | -7684 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Mcm8 | -4545 | -5868 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cdc6 | 558 | 3310 |
| Cdt1 | 3752 | 3214 |
| Gm11808 | -5706 | -216 |
| Gmnn | -6348 | -7684 |
| Mcm8 | -4545 | -5868 |
| Orc1 | 2018 | 3208 |
| Orc2 | -52 | 3709 |
| Orc3 | -2266 | -4705 |
| Orc4 | -1216 | -1538 |
| Orc5 | -3013 | -3379 |
| Orc6 | 311 | 1397 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Cross-presentation-of-soluble-exogenous-antigens-(endosomes)
| metric | value |
|---|---|
| setSize | 44 |
| pMANOVA | 0.000519 |
| p.adjustMANOVA | 0.00461 |
| s.dist | 0.289 |
| s.young | -0.271 |
| s.old | -0.1 |
| p.young | 0.00186 |
| p.old | 0.25 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Fcgr1 | 5848 | 4335 |
| Mrc1 | 4115 | -2660 |
| Mrc2 | 7426 | 6606 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
Intra-Golgi-traffic
| metric | value |
|---|---|
| setSize | 41 |
| pMANOVA | 0.00573 |
| p.adjustMANOVA | 0.0332 |
| s.dist | 0.168 |
| s.young | 0.168 |
| s.old | -0.00291 |
| p.young | 0.063 |
| p.old | 0.974 |
| Gene | young | old |
|---|---|---|
| Man2a2 | 3550 | -4096 |
| Cog2 | 2381 | -2488 |
| Cog3 | 1640 | -3468 |
| Gosr2 | 6073 | -777 |
| Ykt6 | 4836 | -818 |
| Vti1a | 2869 | -1116 |
| Man1a | 664 | -2507 |
| Cyth4 | 536 | -1578 |
| Stx16 | 4933 | -115 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Arf1 | -59 | -3518 |
| Bet1l | 5334 | 4588 |
| Cog1 | 3791 | 2760 |
| Cog2 | 2381 | -2488 |
| Cog3 | 1640 | -3468 |
| Cog4 | -3964 | -4303 |
| Cog5 | -5907 | -6472 |
| Cog6 | -3930 | -6209 |
| Cog7 | -2722 | -4763 |
| Cog8 | -6900 | -7344 |
| Cux1 | 6746 | 4816 |
| Cyth1 | -5817 | -6706 |
| Cyth2 | 5383 | 2969 |
| Cyth3 | 7000 | 6420 |
| Cyth4 | 536 | -1578 |
| Golga5 | 4364 | 2357 |
| Golim4 | 7319 | 6690 |
| Gosr1 | -1133 | -2009 |
| Gosr2 | 6073 | -777 |
| Man1a | 664 | -2507 |
| Man1a2 | 5867 | 5756 |
| Man1c1 | 5900 | 2279 |
| Man2a1 | 2682 | 1662 |
| Man2a2 | 3550 | -4096 |
| Napa | -5159 | -4315 |
| Napb | 1860 | 6167 |
| Napg | 2133 | 3081 |
| Nsf | -957 | -3637 |
| Rab30 | -3630 | -2354 |
| Rab33b | 6021 | 3134 |
| Rab36 | 4621 | 4563 |
| Rgp1 | -2686 | -1308 |
| Ric1 | -3551 | -4586 |
| Snap29 | -5199 | -6114 |
| Stx16 | 4933 | -115 |
| Stx5a | 4418 | 3544 |
| Stx6 | 4375 | 3057 |
| Trip11 | -2178 | -3383 |
| Vps45 | 3111 | 3511 |
| Vti1a | 2869 | -1116 |
| Ykt6 | 4836 | -818 |
Regulation-of-Apoptosis
| metric | value |
|---|---|
| setSize | 49 |
| pMANOVA | 1.45e-05 |
| p.adjustMANOVA | 0.000261 |
| s.dist | 0.39 |
| s.young | -0.347 |
| s.old | -0.177 |
| p.young | 2.6e-05 |
| p.old | 0.0317 |
| Gene | young | old |
|---|---|---|
| Opa1 | -6928 | -7669 |
| Psme1 | -7082 | -7176 |
| Oma1 | -6335 | -7529 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Arhgap10 | -5360 | -3726 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Arhgap10 | -5360 | -3726 |
| Gm11808 | -5706 | -216 |
| Oma1 | -6335 | -7529 |
| Opa1 | -6928 | -7669 |
| Pak2 | 1636 | -1595 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Vpu-mediated-degradation-of-CD4
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 5.1e-05 |
| p.adjustMANOVA | 0.000725 |
| s.dist | 0.358 |
| s.young | -0.323 |
| s.old | -0.154 |
| p.young | 0.000109 |
| p.old | 0.0644 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Skp1a | -2255 | -5461 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Btrc | -983 | -2965 |
| Cd4 | -2571 | -2169 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Skp1a | -2255 | -5461 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Degradation-of-AXIN
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 0.000292 |
| p.adjustMANOVA | 0.00294 |
| s.dist | 0.276 |
| s.young | -0.259 |
| s.old | -0.0933 |
| p.young | 0.00136 |
| p.old | 0.249 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Tnks2 | -4497 | -6705 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Axin1 | 3573 | 2919 |
| Axin2 | 5432 | 6015 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rnf146 | -2003 | 400 |
| Rps27a | -1504 | -1029 |
| Smurf2 | 5768 | 4293 |
| Tnks | 3088 | 977 |
| Tnks2 | -4497 | -6705 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Vif-mediated-degradation-of-APOBEC3G
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 3.71e-05 |
| p.adjustMANOVA | 0.000565 |
| s.dist | 0.376 |
| s.young | -0.335 |
| s.old | -0.17 |
| p.young | 5.91e-05 |
| p.old | 0.0414 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Rbx1 | -4743 | -4554 |
| Psmc3 | -5727 | -3198 |
| Eloc | -3360 | -5140 |
| Psmc5 | -5068 | -3092 |
| Cul5 | -2055 | -6542 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cul5 | -2055 | -6542 |
| Eloc | -3360 | -5140 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rbx1 | -4743 | -4554 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Class-I-peroxisomal-membrane-protein-import
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 0.00017 |
| p.adjustMANOVA | 0.0019 |
| s.dist | 0.66 |
| s.young | -0.377 |
| s.old | -0.542 |
| p.young | 0.00441 |
| p.old | 4.3e-05 |
| Gene | young | old |
|---|---|---|
| Pxmp2 | -6949 | -7658 |
| Abcd3 | -6653 | -7370 |
| Pxmp4 | -6593 | -7236 |
| Pex19 | -6534 | -6309 |
| Abcd1 | -6190 | -6228 |
| Pex2 | -5398 | -6265 |
| Abcd2 | -5558 | -4862 |
| Pex11b | -3864 | -5317 |
| Atad1 | -3794 | -5152 |
| Pex16 | -3583 | -3499 |
| Fis1 | -3956 | -2973 |
| Pex26 | -2597 | -2650 |
| Pex13 | -771 | -5620 |
| Slc25a17 | -336 | -4956 |
| Aldh3a2 | -30 | -948 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abcd1 | -6190 | -6228 |
| Abcd2 | -5558 | -4862 |
| Abcd3 | -6653 | -7370 |
| Acbd5 | 6712 | 4401 |
| Aldh3a2 | -30 | -948 |
| Atad1 | -3794 | -5152 |
| Fis1 | -3956 | -2973 |
| Pex11b | -3864 | -5317 |
| Pex12 | 2346 | -4157 |
| Pex13 | -771 | -5620 |
| Pex14 | 809 | -2777 |
| Pex16 | -3583 | -3499 |
| Pex19 | -6534 | -6309 |
| Pex2 | -5398 | -6265 |
| Pex26 | -2597 | -2650 |
| Pex3 | 1333 | -4235 |
| Pxmp2 | -6949 | -7658 |
| Pxmp4 | -6593 | -7236 |
| Slc25a17 | -336 | -4956 |
Negative-regulation-of-NOTCH4-signaling
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 0.000122 |
| p.adjustMANOVA | 0.00147 |
| s.dist | 0.318 |
| s.young | -0.291 |
| s.old | -0.128 |
| p.young | 0.000329 |
| p.old | 0.114 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Akt1 | -6210 | -5765 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Rbx1 | -4743 | -4554 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Skp1a | -2255 | -5461 |
| Cul1 | -3119 | -3855 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Akt1 | -6210 | -5765 |
| Cul1 | -3119 | -3855 |
| Fbxw7 | -1767 | 3232 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psmf1 | 1562 | 263 |
| Rbx1 | -4743 | -4554 |
| Rps27a | -1504 | -1029 |
| Skp1a | -2255 | -5461 |
| Tacc3 | 6168 | 3333 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Ywhaz | 5524 | 2659 |
SCF-beta-TrCP-mediated-degradation-of-Emi1
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 8.26e-05 |
| p.adjustMANOVA | 0.00106 |
| s.dist | 0.335 |
| s.young | -0.303 |
| s.old | -0.142 |
| p.young | 0.000181 |
| p.old | 0.0802 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Skp1a | -2255 | -5461 |
| Cul1 | -3119 | -3855 |
| Psmb4 | -4157 | -2719 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Btrc | -983 | -2965 |
| Cdc20 | 1433 | 3116 |
| Cul1 | -3119 | -3855 |
| Fbxo5 | 2497 | 2209 |
| Fzr1 | -2816 | -3420 |
| Gm11808 | -5706 | -216 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Skp1a | -2255 | -5461 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
DARPP-32-events
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 0.0079 |
| p.adjustMANOVA | 0.0431 |
| s.dist | 0.395 |
| s.young | -0.187 |
| s.old | -0.348 |
| p.young | 0.129 |
| p.old | 0.00475 |
| Gene | young | old |
|---|---|---|
| Pde4a | -7051 | -7640 |
| Pde4c | -6981 | -7481 |
| Pde4d | -6468 | -7754 |
| Prkaca | -6075 | -5990 |
| Ppp3cb | -5310 | -6375 |
| Calm1 | -4595 | -4970 |
| Prkar2a | -4064 | -4969 |
| Ppp2r1a | -5112 | -3845 |
| Ppp2r5d | -3601 | -2560 |
| Ppp3ca | -1178 | -2997 |
| Ppp1ca | -2389 | -1250 |
| Ppp2r1b | -1090 | -2605 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Calm1 | -4595 | -4970 |
| Cdk5 | -807 | 351 |
| Pde4a | -7051 | -7640 |
| Pde4b | 5944 | -1416 |
| Pde4c | -6981 | -7481 |
| Pde4d | -6468 | -7754 |
| Ppp1ca | -2389 | -1250 |
| Ppp2ca | 1302 | 1549 |
| Ppp2cb | 2162 | -1862 |
| Ppp2r1a | -5112 | -3845 |
| Ppp2r1b | -1090 | -2605 |
| Ppp2r5d | -3601 | -2560 |
| Ppp3ca | -1178 | -2997 |
| Ppp3cb | -5310 | -6375 |
| Ppp3cc | 483 | -771 |
| Ppp3r1 | 1460 | -6334 |
| Prkaca | -6075 | -5990 |
| Prkacb | 3875 | -3919 |
| Prkar1a | 6142 | 4210 |
| Prkar1b | 1256 | 1039 |
| Prkar2a | -4064 | -4969 |
| Prkar2b | 3433 | 313 |
Regulation-of-RUNX3-expression-and-activity
| metric | value |
|---|---|
| setSize | 52 |
| pMANOVA | 0.00251 |
| p.adjustMANOVA | 0.0165 |
| s.dist | 0.177 |
| s.young | -0.176 |
| s.old | -0.0165 |
| p.young | 0.0283 |
| p.old | 0.837 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
| Psmd6 | -2219 | -3583 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Cbfb | 5644 | 4451 |
| Ep300 | -2809 | -454 |
| Gm11808 | -5706 | -216 |
| Mdm2 | 4383 | 4102 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Runx3 | 2355 | 4039 |
| Smurf1 | 6281 | 2428 |
| Smurf2 | 5768 | 4293 |
| Src | 7196 | 6795 |
| Tgfb1 | 6984 | 5531 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein
| metric | value |
|---|---|
| setSize | 69 |
| pMANOVA | 0.000668 |
| p.adjustMANOVA | 0.00577 |
| s.dist | 0.143 |
| s.young | 0.142 |
| s.old | -0.0172 |
| p.young | 0.0415 |
| p.old | 0.804 |
| Gene | young | old |
|---|---|---|
| St3gal4 | 4466 | -4957 |
| Rft1 | 3829 | -5039 |
| St6galnac2 | 5684 | -2059 |
| St6gal1 | 4351 | -2022 |
| Dpm3 | 1522 | -4346 |
| Dolpp1 | 921 | -3874 |
| Nus1 | 1719 | -1890 |
| Nagk | 3592 | -731 |
| Gne | 1172 | -1633 |
| Fcsk | 1861 | -708 |
| St6galnac3 | 48 | -5018 |
| Fpgt | 1415 | -71 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Alg1 | 6726 | 5694 |
| Alg10b | -4303 | -7294 |
| Alg11 | -1229 | -3115 |
| Alg12 | -2699 | -3881 |
| Alg14 | 474 | 3160 |
| Alg2 | -518 | -1267 |
| Alg3 | -322 | -2230 |
| Alg5 | 5916 | 5071 |
| Alg6 | -1841 | -4848 |
| Alg8 | 1524 | 339 |
| Alg9 | -2204 | -6400 |
| Amdhd2 | 4916 | 2058 |
| Cmas | 3263 | 831 |
| Ctsa | 3546 | 448 |
| Dhdds | 4837 | 4695 |
| Dolk | -5587 | -3086 |
| Dolpp1 | 921 | -3874 |
| Dpagt1 | -2089 | -1947 |
| Dpm1 | -1101 | -5227 |
| Dpm2 | 4502 | 2233 |
| Dpm3 | 1522 | -4346 |
| Fcsk | 1861 | -708 |
| Fpgt | 1415 | -71 |
| Fuom | -6371 | -3820 |
| Gfpt1 | 4092 | 919 |
| Gfpt2 | -5090 | 1134 |
| Glb1 | 5822 | 1047 |
| Gmds | 3531 | 4447 |
| Gmppa | 3080 | 1628 |
| Gmppb | 1721 | 2324 |
| Gne | 1172 | -1633 |
| Gnpnat1 | 4972 | 1038 |
| Mpdu1 | 5512 | 3468 |
| Mpi | -7175 | -6989 |
| Mvd | -786 | 1263 |
| Nagk | 3592 | -731 |
| Nanp | 2835 | 1684 |
| Nans | 6392 | 4932 |
| Neu1 | -4503 | -122 |
| Neu3 | -2654 | -2701 |
| Npl | 2978 | 1243 |
| Nudt14 | -7278 | -7587 |
| Nus1 | 1719 | -1890 |
| Pgm3 | 5901 | 4554 |
| Pmm1 | 7486 | 6895 |
| Pmm2 | -3323 | -5784 |
| Renbp | 4245 | 2617 |
| Rft1 | 3829 | -5039 |
| Slc17a5 | 4456 | 2342 |
| Slc35a1 | 4230 | 111 |
| Slc35c1 | 2466 | 1410 |
| Srd5a3 | 4993 | 3726 |
| St3gal1 | 3058 | 716 |
| St3gal2 | 6995 | 5852 |
| St3gal3 | -6777 | -6624 |
| St3gal4 | 4466 | -4957 |
| St3gal5 | 5507 | 3409 |
| St3gal6 | -4673 | -4593 |
| St6gal1 | 4351 | -2022 |
| St6galnac2 | 5684 | -2059 |
| St6galnac3 | 48 | -5018 |
| St6galnac4 | 6331 | 6062 |
| St6galnac6 | -7184 | -7584 |
| St8sia1 | 6367 | 6714 |
| St8sia2 | 4491 | 4888 |
| St8sia4 | -6404 | -5155 |
| St8sia6 | -1521 | -4549 |
| Tsta3 | -4656 | -3516 |
| Uap1 | -4914 | -3592 |
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint
| metric | value |
|---|---|
| setSize | 55 |
| pMANOVA | 0.00173 |
| p.adjustMANOVA | 0.0127 |
| s.dist | 0.179 |
| s.young | -0.178 |
| s.old | -0.019 |
| p.young | 0.0223 |
| p.old | 0.808 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Psmc3 | -5727 | -3198 |
| Psmc5 | -5068 | -3092 |
| Psmb5 | -5358 | -2463 |
| Psmd1 | -4493 | -2930 |
| Psmd3 | -5414 | -2387 |
| Psmb4 | -4157 | -2719 |
| Psmd2 | -4258 | -2549 |
| Psme2b | -2823 | -3837 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ccnb1 | 4674 | 4624 |
| Ccnb2 | 5296 | 3604 |
| Cdk1 | 5710 | 3875 |
| Cdkn1a | 5001 | 5540 |
| Fkbpl | 686 | 829 |
| Gm11808 | -5706 | -216 |
| Gtse1 | 4236 | 4258 |
| Hsp90ab1 | -3870 | -989 |
| Mapre1 | 5505 | 2614 |
| Plk1 | 4893 | 4675 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rps27a | -1504 | -1029 |
| Trp53 | 4978 | 4881 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0 beeswarm_0.2.3 gtools_3.8.2
## [5] echarts4r_0.3.2 mitch_1.0.6 gplots_3.0.3 reshape2_1.4.4
## [9] forcats_0.5.0 stringr_1.4.0 dplyr_1.0.0 purrr_0.3.4
## [13] readr_1.3.1 tidyr_1.1.0 tibble_3.0.1 ggplot2_3.3.2
## [17] tidyverse_1.3.0
##
## loaded via a namespace (and not attached):
## [1] nlme_3.1-148 bitops_1.0-6 fs_1.4.2 lubridate_1.7.9
## [5] RColorBrewer_1.1-2 httr_1.4.1 rprojroot_1.3-2 tools_4.0.2
## [9] backports_1.1.8 R6_2.4.1 KernSmooth_2.23-17 DBI_1.1.0
## [13] colorspace_1.4-1 withr_2.2.0 tidyselect_1.1.0 gridExtra_2.3
## [17] compiler_4.0.2 cli_2.0.2 rvest_0.3.5 xml2_1.3.2
## [21] desc_1.2.0 labeling_0.3 caTools_1.18.0 scales_1.1.1
## [25] digest_0.6.25 rmarkdown_2.3 pkgconfig_2.0.3 htmltools_0.5.0
## [29] dbplyr_1.4.4 fastmap_1.0.1 highr_0.8 htmlwidgets_1.5.1
## [33] rlang_0.4.6 readxl_1.3.1 rstudioapi_0.11 shiny_1.5.0
## [37] generics_0.0.2 farver_2.0.3 jsonlite_1.7.0 magrittr_1.5
## [41] Rcpp_1.0.4.6 munsell_0.5.0 fansi_0.4.1 lifecycle_0.2.0
## [45] stringi_1.4.6 yaml_2.2.1 MASS_7.3-51.6 plyr_1.8.6
## [49] grid_4.0.2 blob_1.2.1 parallel_4.0.2 gdata_2.18.0
## [53] promises_1.1.1 crayon_1.3.4 lattice_0.20-41 haven_2.3.1
## [57] hms_0.5.3 knitr_1.29 pillar_1.4.4 reprex_0.3.0
## [61] glue_1.4.1 evaluate_0.14 modelr_0.1.8 vctrs_0.3.1
## [65] httpuv_1.5.4 testthat_2.3.2 cellranger_1.1.0 gtable_0.3.0
## [69] reshape_0.8.8 assertthat_0.2.1 xfun_0.15 mime_0.9
## [73] xtable_1.8-4 broom_0.5.6 later_1.1.0.1 pbmcapply_1.5.0
## [77] ellipsis_0.3.1END of report