Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-07-10
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## young old
## 0610009B22Rik -2.9385024 -6.1805927
## 0610009E02Rik 0.6410018 -1.6821055
## 0610009L18Rik -4.5856767 -3.1288917
## 0610010F05Rik 0.6483013 0.4402823
## 0610010K14Rik -8.7879236 -3.0864256
## 0610012G03Rik -8.7415080 -6.4223694Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 14877 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 919 |
| num_profile_genes_not_in_sets | 13958 |
| profile_pearson_correl | 0.8374 |
| profile_spearman_correl | 0.80977 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ../ref/pathways_of_interest_mouse.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 43 |
| num_genesets_excluded | 17 |
| num_genesets_included | 26 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 20 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 26 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.young | s.old | p.young | p.old |
|---|---|---|---|---|---|---|---|---|
| The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport | 167 | 1.25e-82 | 3.26e-81 | 1.1700 | -0.83500 | -0.81300 | 5.14e-78 | 5.46e-74 |
| Respiratory-electron-transport | 100 | 4.63e-57 | 6.01e-56 | 1.2500 | -0.90400 | -0.85900 | 2.80e-55 | 4.76e-50 |
| Mitochondrial-translation | 94 | 6.95e-44 | 6.03e-43 | 1.1200 | -0.82500 | -0.75800 | 1.11e-43 | 4.24e-37 |
| Mitochondrial-protein-import | 57 | 8.67e-23 | 5.64e-22 | 1.0300 | -0.76200 | -0.68600 | 2.29e-23 | 2.95e-19 |
| Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle | 51 | 4.48e-21 | 2.33e-20 | 1.0500 | -0.72500 | -0.76000 | 3.15e-19 | 5.37e-21 |
| Mitochondrial-biogenesis | 88 | 1.70e-19 | 7.38e-19 | 0.7690 | -0.53000 | -0.55700 | 7.78e-18 | 1.67e-19 |
| Mitochondrial-Fatty-Acid-Beta-Oxidation | 31 | 5.13e-17 | 1.91e-16 | 1.2100 | -0.85800 | -0.85000 | 1.25e-16 | 2.49e-16 |
| Citric-acid-cycle-(TCA-cycle) | 22 | 2.51e-13 | 8.16e-13 | 1.2600 | -0.89400 | -0.88900 | 3.71e-13 | 5.02e-13 |
| rRNA-processing-in-the-mitochondrion | 22 | 1.56e-11 | 4.52e-11 | 1.1600 | -0.78300 | -0.85400 | 2.00e-10 | 3.93e-12 |
| Branched-chain-amino-acid-catabolism | 19 | 5.85e-11 | 1.52e-10 | 1.2200 | -0.85900 | -0.87100 | 9.04e-11 | 4.89e-11 |
| Mitochondrial-tRNA-aminoacylation | 19 | 3.66e-08 | 8.37e-08 | 1.0400 | -0.75600 | -0.71200 | 1.14e-08 | 7.59e-08 |
| Transcriptional-activation-of-mitochondrial-biogenesis | 51 | 3.86e-08 | 8.37e-08 | 0.6280 | -0.41800 | -0.46800 | 2.43e-07 | 7.23e-09 |
| Mitochondrial-iron-sulfur-cluster-biogenesis | 10 | 6.99e-05 | 1.40e-04 | 1.0700 | -0.74100 | -0.77500 | 4.95e-05 | 2.19e-05 |
| Mitochondrial-calcium-ion-transport | 21 | 1.53e-04 | 2.84e-04 | 0.7100 | -0.49500 | -0.50900 | 8.64e-05 | 5.32e-05 |
| Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha | 60 | 4.60e-04 | 7.97e-04 | 0.3230 | -0.27600 | -0.16700 | 2.17e-04 | 2.57e-02 |
| Cellular-response-to-hypoxia | 68 | 8.97e-04 | 1.46e-03 | 0.2900 | -0.24800 | -0.15000 | 4.10e-04 | 3.31e-02 |
| Smooth-Muscle-Contraction | 31 | 9.21e-03 | 1.41e-02 | 0.2130 | 0.03140 | 0.21100 | 7.62e-01 | 4.21e-02 |
| Glycolysis | 63 | 1.43e-02 | 2.07e-02 | 0.2360 | -0.12400 | -0.20100 | 8.98e-02 | 5.71e-03 |
| Signaling-by-Hippo | 20 | 1.54e-02 | 2.11e-02 | 0.4840 | 0.37300 | 0.30900 | 3.88e-03 | 1.67e-02 |
| Muscle-contraction | 148 | 2.98e-02 | 3.87e-02 | 0.0555 | -0.04380 | 0.03410 | 3.59e-01 | 4.74e-01 |
| Cardiac-conduction | 95 | 1.52e-01 | 1.88e-01 | 0.1320 | -0.11100 | -0.07140 | 6.17e-02 | 2.29e-01 |
| TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain | 11 | 2.72e-01 | 3.21e-01 | 0.1730 | 0.00972 | 0.17300 | 9.55e-01 | 3.21e-01 |
| Intrinsic-Pathway-for-Apoptosis | 47 | 5.75e-01 | 6.50e-01 | 0.0485 | 0.04830 | -0.00457 | 5.67e-01 | 9.57e-01 |
| Regulation-of-gene-expression-by-Hypoxia-inducible-Factor | 10 | 7.99e-01 | 8.63e-01 | 0.0870 | -0.01730 | -0.08520 | 9.24e-01 | 6.41e-01 |
| Apoptosis | 152 | 8.29e-01 | 8.63e-01 | 0.0142 | -0.01370 | 0.00372 | 7.70e-01 | 9.37e-01 |
| Fatty-acyl-CoA-biosynthesis | 28 | 8.78e-01 | 8.78e-01 | 0.0712 | -0.04450 | -0.05560 | 6.84e-01 | 6.11e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.young | s.old | p.young | p.old |
|---|---|---|---|---|---|---|---|---|
| The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport | 167 | 1.25e-82 | 3.26e-81 | 1.1700 | -0.83500 | -0.81300 | 5.14e-78 | 5.46e-74 |
| Respiratory-electron-transport | 100 | 4.63e-57 | 6.01e-56 | 1.2500 | -0.90400 | -0.85900 | 2.80e-55 | 4.76e-50 |
| Mitochondrial-translation | 94 | 6.95e-44 | 6.03e-43 | 1.1200 | -0.82500 | -0.75800 | 1.11e-43 | 4.24e-37 |
| Mitochondrial-protein-import | 57 | 8.67e-23 | 5.64e-22 | 1.0300 | -0.76200 | -0.68600 | 2.29e-23 | 2.95e-19 |
| Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle | 51 | 4.48e-21 | 2.33e-20 | 1.0500 | -0.72500 | -0.76000 | 3.15e-19 | 5.37e-21 |
| Mitochondrial-biogenesis | 88 | 1.70e-19 | 7.38e-19 | 0.7690 | -0.53000 | -0.55700 | 7.78e-18 | 1.67e-19 |
| Mitochondrial-Fatty-Acid-Beta-Oxidation | 31 | 5.13e-17 | 1.91e-16 | 1.2100 | -0.85800 | -0.85000 | 1.25e-16 | 2.49e-16 |
| Citric-acid-cycle-(TCA-cycle) | 22 | 2.51e-13 | 8.16e-13 | 1.2600 | -0.89400 | -0.88900 | 3.71e-13 | 5.02e-13 |
| rRNA-processing-in-the-mitochondrion | 22 | 1.56e-11 | 4.52e-11 | 1.1600 | -0.78300 | -0.85400 | 2.00e-10 | 3.93e-12 |
| Branched-chain-amino-acid-catabolism | 19 | 5.85e-11 | 1.52e-10 | 1.2200 | -0.85900 | -0.87100 | 9.04e-11 | 4.89e-11 |
| Mitochondrial-tRNA-aminoacylation | 19 | 3.66e-08 | 8.37e-08 | 1.0400 | -0.75600 | -0.71200 | 1.14e-08 | 7.59e-08 |
| Transcriptional-activation-of-mitochondrial-biogenesis | 51 | 3.86e-08 | 8.37e-08 | 0.6280 | -0.41800 | -0.46800 | 2.43e-07 | 7.23e-09 |
| Mitochondrial-iron-sulfur-cluster-biogenesis | 10 | 6.99e-05 | 1.40e-04 | 1.0700 | -0.74100 | -0.77500 | 4.95e-05 | 2.19e-05 |
| Mitochondrial-calcium-ion-transport | 21 | 1.53e-04 | 2.84e-04 | 0.7100 | -0.49500 | -0.50900 | 8.64e-05 | 5.32e-05 |
| Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha | 60 | 4.60e-04 | 7.97e-04 | 0.3230 | -0.27600 | -0.16700 | 2.17e-04 | 2.57e-02 |
| Cellular-response-to-hypoxia | 68 | 8.97e-04 | 1.46e-03 | 0.2900 | -0.24800 | -0.15000 | 4.10e-04 | 3.31e-02 |
| Smooth-Muscle-Contraction | 31 | 9.21e-03 | 1.41e-02 | 0.2130 | 0.03140 | 0.21100 | 7.62e-01 | 4.21e-02 |
| Glycolysis | 63 | 1.43e-02 | 2.07e-02 | 0.2360 | -0.12400 | -0.20100 | 8.98e-02 | 5.71e-03 |
| Signaling-by-Hippo | 20 | 1.54e-02 | 2.11e-02 | 0.4840 | 0.37300 | 0.30900 | 3.88e-03 | 1.67e-02 |
| Muscle-contraction | 148 | 2.98e-02 | 3.87e-02 | 0.0555 | -0.04380 | 0.03410 | 3.59e-01 | 4.74e-01 |
| Cardiac-conduction | 95 | 1.52e-01 | 1.88e-01 | 0.1320 | -0.11100 | -0.07140 | 6.17e-02 | 2.29e-01 |
| TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain | 11 | 2.72e-01 | 3.21e-01 | 0.1730 | 0.00972 | 0.17300 | 9.55e-01 | 3.21e-01 |
| Intrinsic-Pathway-for-Apoptosis | 47 | 5.75e-01 | 6.50e-01 | 0.0485 | 0.04830 | -0.00457 | 5.67e-01 | 9.57e-01 |
| Regulation-of-gene-expression-by-Hypoxia-inducible-Factor | 10 | 7.99e-01 | 8.63e-01 | 0.0870 | -0.01730 | -0.08520 | 9.24e-01 | 6.41e-01 |
| Apoptosis | 152 | 8.29e-01 | 8.63e-01 | 0.0142 | -0.01370 | 0.00372 | 7.70e-01 | 9.37e-01 |
| Fatty-acyl-CoA-biosynthesis | 28 | 8.78e-01 | 8.78e-01 | 0.0712 | -0.04450 | -0.05560 | 6.84e-01 | 6.11e-01 |
Detailed Gene set reports
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport
| metric | value |
|---|---|
| setSize | 167 |
| pMANOVA | 1.25e-82 |
| p.adjustMANOVA | 3.26e-81 |
| s.dist | 1.17 |
| s.young | -0.835 |
| s.old | -0.813 |
| p.young | 5.14e-78 |
| p.old | 5.46e-74 |
| Gene | young | old |
|---|---|---|
| Adhfe1 | -7349 | -7821 |
| Ldhb | -7348 | -7811 |
| Sdha | -7346 | -7813 |
| Ndufb8 | -7343 | -7800 |
| Atp5o | -7347 | -7794 |
| Sdhd | -7333 | -7791 |
| Etfa | -7323 | -7764 |
| Etfdh | -7269 | -7789 |
| Ndufc2 | -7325 | -7719 |
| Ndufa9 | -7317 | -7720 |
| Atp5l | -7340 | -7690 |
| Uqcr11 | -7327 | -7657 |
| Sucla2 | -7292 | -7689 |
| Mpc2 | -7294 | -7670 |
| Ndufv2 | -7260 | -7683 |
| Suclg2 | -7193 | -7724 |
| Uqcrfs1 | -7311 | -7599 |
| Idh3b | -7322 | -7586 |
| Dld | -7216 | -7696 |
| Uqcrh | -7334 | -7571 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acad9 | -6612 | -6647 |
| Aco2 | -6436 | -6977 |
| Adhfe1 | -7349 | -7821 |
| Atp5a1 | -7220 | -7504 |
| Atp5b | -7224 | -7258 |
| Atp5c1 | -7207 | -7515 |
| Atp5d | -7173 | -6303 |
| Atp5e | -7150 | -6015 |
| Atp5g3 | -7235 | -7573 |
| Atp5h | -7284 | -7352 |
| Atp5j | -7206 | -7420 |
| Atp5j2 | -7093 | -7135 |
| Atp5k | -5830 | -7288 |
| Atp5l | -7340 | -7690 |
| Atp5o | -7347 | -7794 |
| Atp5pb | -7213 | -7607 |
| Bsg | -6548 | -7267 |
| Coq10a | -7209 | -7269 |
| Coq10b | -5270 | -2925 |
| Cox11 | -4941 | -6003 |
| Cox14 | -7095 | -6340 |
| Cox16 | -5100 | -3654 |
| Cox18 | -4863 | -4177 |
| Cox19 | 6674 | 6213 |
| Cox20 | -4854 | -5240 |
| Cox4i1 | -7272 | -7222 |
| Cox5a | -7164 | -7617 |
| Cox5b | -6986 | -7126 |
| Cox6a1 | -5249 | -3806 |
| Cox6b1 | -7136 | -6612 |
| Cox6c | -7114 | -7331 |
| Cox7a2l | -6270 | -6466 |
| Cox7b | -7084 | -7330 |
| Cox7c | -6438 | -7237 |
| Cox8a | -3627 | -1367 |
| Cs | -7238 | -7580 |
| Cyc1 | -7237 | -7220 |
| Cycs | -7133 | -7302 |
| D2hgdh | -7104 | -7565 |
| Dlat | -7003 | -7332 |
| Dld | -7216 | -7696 |
| Dlst | -7165 | -7693 |
| Dmac2l | -6520 | -7171 |
| Ecsit | -6908 | -6444 |
| Etfa | -7323 | -7764 |
| Etfb | -7336 | -7558 |
| Etfdh | -7269 | -7789 |
| Fahd1 | -7052 | -7556 |
| Fh1 | -7115 | -7449 |
| Glo1 | -5689 | -5454 |
| Gstz1 | -6066 | -6846 |
| Hagh | 3129 | -1329 |
| Idh2 | -6961 | -7381 |
| Idh3a | -7085 | -7634 |
| Idh3b | -7322 | -7586 |
| Idh3g | -7228 | -7314 |
| L2hgdh | -6879 | -7484 |
| Ldha | 3559 | -4312 |
| Ldhb | -7348 | -7811 |
| Lrpprc | -7024 | -7746 |
| Mdh2 | -7233 | -7179 |
| Me1 | -6765 | -6942 |
| Me2 | 5856 | 4582 |
| Me3 | -7147 | -7472 |
| Mpc1 | -7043 | -7036 |
| Mpc2 | -7294 | -7670 |
| mt-Atp6 | -7229 | -7101 |
| mt-Atp8 | -3257 | -6724 |
| mt-Co1 | -7257 | -7632 |
| mt-Co2 | -7163 | -6523 |
| mt-Co3 | -7307 | -7023 |
| mt-Cytb | -6947 | -7620 |
| mt-Nd1 | -7119 | -7489 |
| mt-Nd2 | -7271 | -7495 |
| mt-Nd3 | -6642 | -5922 |
| mt-Nd4 | -6682 | -7382 |
| mt-Nd5 | -6386 | -7564 |
| mt-Nd6 | -6677 | -7251 |
| Ndufa1 | -5430 | -6709 |
| Ndufa10 | -7288 | -7572 |
| Ndufa11 | -7330 | -7448 |
| Ndufa12 | -7240 | -7308 |
| Ndufa13 | -7053 | -7089 |
| Ndufa2 | -6895 | -6030 |
| Ndufa3 | -7000 | -7510 |
| Ndufa4 | -7274 | -7232 |
| Ndufa5 | -7189 | -7647 |
| Ndufa6 | -6698 | -7117 |
| Ndufa7 | -7328 | -7459 |
| Ndufa8 | -7315 | -7154 |
| Ndufa9 | -7317 | -7720 |
| Ndufab1 | -7247 | -7579 |
| Ndufaf1 | -7011 | -7559 |
| Ndufaf2 | -4758 | -5261 |
| Ndufaf3 | -4910 | -5440 |
| Ndufaf4 | -6419 | -7254 |
| Ndufaf5 | -5750 | -6463 |
| Ndufaf6 | -6271 | -7083 |
| Ndufaf7 | -5738 | -6678 |
| Ndufb1-ps | -5319 | -6906 |
| Ndufb10 | -7199 | -7209 |
| Ndufb2 | -7214 | -7114 |
| Ndufb3 | -6549 | -6607 |
| Ndufb4 | -7132 | -7245 |
| Ndufb5 | -7181 | -6935 |
| Ndufb6 | -6950 | -7112 |
| Ndufb7 | -7225 | -6331 |
| Ndufb8 | -7343 | -7800 |
| Ndufb9 | -7140 | -7223 |
| Ndufc1 | -6951 | -7311 |
| Ndufc2 | -7325 | -7719 |
| Ndufs1 | -7157 | -7633 |
| Ndufs2 | -7314 | -7534 |
| Ndufs3 | -7291 | -7530 |
| Ndufs4 | -7275 | -7583 |
| Ndufs5 | -7010 | -7087 |
| Ndufs6 | -7098 | -7550 |
| Ndufs7 | -7258 | -6981 |
| Ndufs8 | -7303 | -7304 |
| Ndufv1 | -7186 | -6904 |
| Ndufv2 | -7260 | -7683 |
| Ndufv3 | -7034 | -7419 |
| Nnt | -6917 | -7798 |
| Nubpl | -6153 | -6907 |
| Ogdh | -7013 | -7475 |
| Pdha1 | -7106 | -7283 |
| Pdhb | -7169 | -7319 |
| Pdhx | -7172 | -7679 |
| Pdk1 | 4156 | -6364 |
| Pdk2 | -6889 | -7055 |
| Pdk3 | 6805 | 6440 |
| Pdk4 | -1655 | 1645 |
| Pdp1 | -4181 | -5275 |
| Pdp2 | -5917 | -7570 |
| Pdpr | -5996 | -7506 |
| Ppard | -5588 | -4490 |
| Rxra | -6194 | -6804 |
| Sco1 | -6462 | -6322 |
| Sco2 | -3709 | -4161 |
| Sdha | -7346 | -7813 |
| Sdhb | -7295 | -7485 |
| Sdhc | -7227 | -7405 |
| Sdhd | -7333 | -7791 |
| Slc16a1 | -5936 | -4200 |
| Slc16a3 | 7305 | 6044 |
| Slc16a8 | -4482 | -3791 |
| Slc25a14 | 4008 | 2705 |
| Slc25a27 | 1019 | 1297 |
| Sucla2 | -7292 | -7689 |
| Suclg1 | -7259 | -7645 |
| Suclg2 | -7193 | -7724 |
| Surf1 | -5087 | -5645 |
| Taco1 | -6970 | -7208 |
| Timmdc1 | -6360 | -5463 |
| Tmem126b | -5883 | -7021 |
| Trap1 | -6975 | -6844 |
| Ucp2 | -3935 | 3288 |
| Ucp3 | -3606 | -5388 |
| Uqcr10 | -6171 | -4525 |
| Uqcr11 | -7327 | -7657 |
| Uqcrb | -6857 | -7389 |
| Uqcrc1 | -7297 | -7415 |
| Uqcrc2 | -7191 | -7618 |
| Uqcrfs1 | -7311 | -7599 |
| Uqcrh | -7334 | -7571 |
| Uqcrq | -7158 | -7033 |
| Vdac1 | -7008 | -7195 |
Respiratory-electron-transport
| metric | value |
|---|---|
| setSize | 100 |
| pMANOVA | 4.63e-57 |
| p.adjustMANOVA | 6.01e-56 |
| s.dist | 1.25 |
| s.young | -0.904 |
| s.old | -0.859 |
| p.young | 2.8e-55 |
| p.old | 4.76e-50 |
| Gene | young | old |
|---|---|---|
| Sdha | -7346 | -7813 |
| Ndufb8 | -7343 | -7800 |
| Sdhd | -7333 | -7791 |
| Etfa | -7323 | -7764 |
| Etfdh | -7269 | -7789 |
| Ndufc2 | -7325 | -7719 |
| Ndufa9 | -7317 | -7720 |
| Uqcr11 | -7327 | -7657 |
| Ndufv2 | -7260 | -7683 |
| Uqcrfs1 | -7311 | -7599 |
| Uqcrh | -7334 | -7571 |
| Etfb | -7336 | -7558 |
| mt-Co1 | -7257 | -7632 |
| Ndufa10 | -7288 | -7572 |
| Ndufs4 | -7275 | -7583 |
| Ndufs2 | -7314 | -7534 |
| Ndufa5 | -7189 | -7647 |
| Ndufab1 | -7247 | -7579 |
| Ndufs3 | -7291 | -7530 |
| Uqcrc2 | -7191 | -7618 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acad9 | -6612 | -6647 |
| Coq10a | -7209 | -7269 |
| Coq10b | -5270 | -2925 |
| Cox11 | -4941 | -6003 |
| Cox14 | -7095 | -6340 |
| Cox16 | -5100 | -3654 |
| Cox18 | -4863 | -4177 |
| Cox19 | 6674 | 6213 |
| Cox20 | -4854 | -5240 |
| Cox4i1 | -7272 | -7222 |
| Cox5a | -7164 | -7617 |
| Cox5b | -6986 | -7126 |
| Cox6a1 | -5249 | -3806 |
| Cox6b1 | -7136 | -6612 |
| Cox6c | -7114 | -7331 |
| Cox7a2l | -6270 | -6466 |
| Cox7b | -7084 | -7330 |
| Cox7c | -6438 | -7237 |
| Cox8a | -3627 | -1367 |
| Cyc1 | -7237 | -7220 |
| Cycs | -7133 | -7302 |
| Ecsit | -6908 | -6444 |
| Etfa | -7323 | -7764 |
| Etfb | -7336 | -7558 |
| Etfdh | -7269 | -7789 |
| Lrpprc | -7024 | -7746 |
| mt-Co1 | -7257 | -7632 |
| mt-Co2 | -7163 | -6523 |
| mt-Co3 | -7307 | -7023 |
| mt-Cytb | -6947 | -7620 |
| mt-Nd1 | -7119 | -7489 |
| mt-Nd2 | -7271 | -7495 |
| mt-Nd3 | -6642 | -5922 |
| mt-Nd4 | -6682 | -7382 |
| mt-Nd5 | -6386 | -7564 |
| mt-Nd6 | -6677 | -7251 |
| Ndufa1 | -5430 | -6709 |
| Ndufa10 | -7288 | -7572 |
| Ndufa11 | -7330 | -7448 |
| Ndufa12 | -7240 | -7308 |
| Ndufa13 | -7053 | -7089 |
| Ndufa2 | -6895 | -6030 |
| Ndufa3 | -7000 | -7510 |
| Ndufa4 | -7274 | -7232 |
| Ndufa5 | -7189 | -7647 |
| Ndufa6 | -6698 | -7117 |
| Ndufa7 | -7328 | -7459 |
| Ndufa8 | -7315 | -7154 |
| Ndufa9 | -7317 | -7720 |
| Ndufab1 | -7247 | -7579 |
| Ndufaf1 | -7011 | -7559 |
| Ndufaf2 | -4758 | -5261 |
| Ndufaf3 | -4910 | -5440 |
| Ndufaf4 | -6419 | -7254 |
| Ndufaf5 | -5750 | -6463 |
| Ndufaf6 | -6271 | -7083 |
| Ndufaf7 | -5738 | -6678 |
| Ndufb1-ps | -5319 | -6906 |
| Ndufb10 | -7199 | -7209 |
| Ndufb2 | -7214 | -7114 |
| Ndufb3 | -6549 | -6607 |
| Ndufb4 | -7132 | -7245 |
| Ndufb5 | -7181 | -6935 |
| Ndufb6 | -6950 | -7112 |
| Ndufb7 | -7225 | -6331 |
| Ndufb8 | -7343 | -7800 |
| Ndufb9 | -7140 | -7223 |
| Ndufc1 | -6951 | -7311 |
| Ndufc2 | -7325 | -7719 |
| Ndufs1 | -7157 | -7633 |
| Ndufs2 | -7314 | -7534 |
| Ndufs3 | -7291 | -7530 |
| Ndufs4 | -7275 | -7583 |
| Ndufs5 | -7010 | -7087 |
| Ndufs6 | -7098 | -7550 |
| Ndufs7 | -7258 | -6981 |
| Ndufs8 | -7303 | -7304 |
| Ndufv1 | -7186 | -6904 |
| Ndufv2 | -7260 | -7683 |
| Ndufv3 | -7034 | -7419 |
| Nubpl | -6153 | -6907 |
| Sco1 | -6462 | -6322 |
| Sco2 | -3709 | -4161 |
| Sdha | -7346 | -7813 |
| Sdhb | -7295 | -7485 |
| Sdhc | -7227 | -7405 |
| Sdhd | -7333 | -7791 |
| Surf1 | -5087 | -5645 |
| Taco1 | -6970 | -7208 |
| Timmdc1 | -6360 | -5463 |
| Tmem126b | -5883 | -7021 |
| Trap1 | -6975 | -6844 |
| Uqcr10 | -6171 | -4525 |
| Uqcr11 | -7327 | -7657 |
| Uqcrb | -6857 | -7389 |
| Uqcrc1 | -7297 | -7415 |
| Uqcrc2 | -7191 | -7618 |
| Uqcrfs1 | -7311 | -7599 |
| Uqcrh | -7334 | -7571 |
| Uqcrq | -7158 | -7033 |
Mitochondrial-translation
| metric | value |
|---|---|
| setSize | 94 |
| pMANOVA | 6.95e-44 |
| p.adjustMANOVA | 6.03e-43 |
| s.dist | 1.12 |
| s.young | -0.825 |
| s.old | -0.758 |
| p.young | 1.11e-43 |
| p.old | 4.24e-37 |
| Gene | young | old |
|---|---|---|
| Mrpl30 | -7337 | -7761 |
| Mrpl42 | -7248 | -7608 |
| Ptcd3 | -7230 | -7612 |
| Mrps35 | -7210 | -7615 |
| Mrps17 | -7178 | -7576 |
| Mrpl2 | -7320 | -7372 |
| Mrps9 | -6971 | -7623 |
| Mrpl45 | -6896 | -7603 |
| Mrpl28 | -6906 | -7373 |
| Tufm | -6846 | -7363 |
| Mrpl9 | -6996 | -7202 |
| Mrpl46 | -6817 | -7379 |
| Mrpl51 | -7056 | -7044 |
| Mtif2 | -6744 | -7351 |
| Gfm1 | -6643 | -7457 |
| Mrps31 | -6624 | -7462 |
| Mrpl3 | -6890 | -7156 |
| Mrps27 | -6764 | -7263 |
| Mrpl1 | -6750 | -7265 |
| Gfm2 | -6544 | -7469 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Aurkaip1 | -6248 | -5678 |
| Chchd1 | -5921 | -5916 |
| Dap3 | -6390 | -6628 |
| Eral1 | -5904 | -6599 |
| Gadd45gip1 | -6867 | -6703 |
| Gfm1 | -6643 | -7457 |
| Gfm2 | -6544 | -7469 |
| Mrpl1 | -6750 | -7265 |
| Mrpl10 | -5595 | -5933 |
| Mrpl11 | -5991 | -5910 |
| Mrpl12 | -7029 | -6604 |
| Mrpl13 | -5916 | -6619 |
| Mrpl14 | -6990 | -6964 |
| Mrpl15 | -6574 | -6827 |
| Mrpl16 | -5878 | -6598 |
| Mrpl17 | -5372 | -4564 |
| Mrpl18 | -6929 | -7035 |
| Mrpl19 | -6834 | -6958 |
| Mrpl2 | -7320 | -7372 |
| Mrpl20 | -5318 | -4089 |
| Mrpl21 | -5591 | -6947 |
| Mrpl22 | -5839 | -6141 |
| Mrpl23 | -6924 | -4943 |
| Mrpl24 | -5493 | -4092 |
| Mrpl27 | -4868 | -4867 |
| Mrpl28 | -6906 | -7373 |
| Mrpl3 | -6890 | -7156 |
| Mrpl30 | -7337 | -7761 |
| Mrpl32 | -5449 | -6000 |
| Mrpl33 | -676 | 3231 |
| Mrpl34 | -6559 | -6570 |
| Mrpl35 | -6678 | -7167 |
| Mrpl36 | -4714 | -4959 |
| Mrpl37 | -6747 | -7068 |
| Mrpl38 | -6844 | -6174 |
| Mrpl39 | -6696 | -7130 |
| Mrpl4 | -6884 | -6566 |
| Mrpl40 | -3530 | -4283 |
| Mrpl41 | -6758 | -6786 |
| Mrpl42 | -7248 | -7608 |
| Mrpl43 | -5164 | -5466 |
| Mrpl44 | -6513 | -6841 |
| Mrpl45 | -6896 | -7603 |
| Mrpl46 | -6817 | -7379 |
| Mrpl47 | -6690 | -6931 |
| Mrpl48 | -4965 | -2296 |
| Mrpl49 | -5909 | -5838 |
| Mrpl50 | -6278 | -7053 |
| Mrpl51 | -7056 | -7044 |
| Mrpl52 | -994 | 253 |
| Mrpl53 | -6252 | -4354 |
| Mrpl54 | -1065 | -2562 |
| Mrpl55 | -7064 | -6715 |
| Mrpl57 | -2056 | -4071 |
| Mrpl58 | -6710 | -6615 |
| Mrpl9 | -6996 | -7202 |
| Mrps10 | -1566 | 1880 |
| Mrps11 | -5399 | -5798 |
| Mrps12 | -4262 | -4111 |
| Mrps14 | -6073 | -6439 |
| Mrps15 | -6805 | -6956 |
| Mrps16 | -6308 | -6130 |
| Mrps17 | -7178 | -7576 |
| Mrps18a | -6175 | -6605 |
| Mrps18b | -5938 | -4872 |
| Mrps18c | -5687 | -6088 |
| Mrps2 | -6425 | -7205 |
| Mrps21 | -6827 | -7070 |
| Mrps22 | -5305 | -6723 |
| Mrps23 | -6635 | -5774 |
| Mrps24 | -6748 | -6081 |
| Mrps25 | -6490 | -6633 |
| Mrps26 | -5415 | -3403 |
| Mrps27 | -6764 | -7263 |
| Mrps28 | -6850 | -6886 |
| Mrps30 | -6407 | -6943 |
| Mrps31 | -6624 | -7462 |
| Mrps33 | -6284 | -6495 |
| Mrps34 | -6156 | -4884 |
| Mrps35 | -7210 | -7615 |
| Mrps36 | -6283 | -6967 |
| Mrps5 | -6689 | -6857 |
| Mrps6 | -4817 | -1971 |
| Mrps7 | -6460 | -6613 |
| Mrps9 | -6971 | -7623 |
| Mrrf | -6453 | -6787 |
| Mtfmt | -3436 | -3006 |
| Mtif2 | -6744 | -7351 |
| Mtif3 | -5780 | -5500 |
| Mtrf1l | -5597 | -5796 |
| Oxa1l | -7035 | -6627 |
| Ptcd3 | -7230 | -7612 |
| Tsfm | -6347 | -6440 |
| Tufm | -6846 | -7363 |
Mitochondrial-protein-import
| metric | value |
|---|---|
| setSize | 57 |
| pMANOVA | 8.67e-23 |
| p.adjustMANOVA | 5.64e-22 |
| s.dist | 1.03 |
| s.young | -0.762 |
| s.old | -0.686 |
| p.young | 2.29e-23 |
| p.old | 2.95e-19 |
| Gene | young | old |
|---|---|---|
| Ndufb8 | -7343 | -7800 |
| Timm23 | -7335 | -7749 |
| Cs | -7238 | -7580 |
| Atp5a1 | -7220 | -7504 |
| Hspa9 | -7037 | -7692 |
| Hspd1 | -6966 | -7697 |
| Grpel1 | -7078 | -7473 |
| Idh3g | -7228 | -7314 |
| Atp5b | -7224 | -7258 |
| Cyc1 | -7237 | -7220 |
| Slc25a4 | -7089 | -7295 |
| Coq2 | -7039 | -7275 |
| Ldhd | -6770 | -7536 |
| Chchd3 | -7066 | -7212 |
| Vdac1 | -7008 | -7195 |
| Slc25a12 | -7001 | -7181 |
| Timm44 | -7154 | -7015 |
| Cmc2 | -6667 | -7225 |
| Samm50 | -7217 | -6662 |
| Pmpca | -6712 | -7102 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Aco2 | -6436 | -6977 |
| Atp5a1 | -7220 | -7504 |
| Atp5b | -7224 | -7258 |
| Bcs1l | -5832 | -6564 |
| Chchd10 | -7262 | -6494 |
| Chchd2 | -7180 | -5992 |
| Chchd3 | -7066 | -7212 |
| Chchd5 | -1580 | -3461 |
| Chchd7 | -6825 | -6448 |
| Cmc2 | -6667 | -7225 |
| Cmc4 | -3869 | 1658 |
| Coa4 | -1599 | 348 |
| Coa6 | -4801 | -4707 |
| Coq2 | -7039 | -7275 |
| Cox19 | 6674 | 6213 |
| Cs | -7238 | -7580 |
| Cyc1 | -7237 | -7220 |
| Fxn | -6784 | -6569 |
| Gfer | -1953 | -4416 |
| Gm45799 | -1631 | 4287 |
| Grpel1 | -7078 | -7473 |
| Grpel2 | -4955 | -6528 |
| Hscb | -1609 | -5700 |
| Hspa9 | -7037 | -7692 |
| Hspd1 | -6966 | -7697 |
| Idh3g | -7228 | -7314 |
| Ldhd | -6770 | -7536 |
| Mtx1 | -5805 | -4557 |
| Mtx2 | -6403 | -6945 |
| Ndufb8 | -7343 | -7800 |
| Pam16 | -5409 | -4217 |
| Pitrm1 | -5821 | -6104 |
| Pmpca | -6712 | -7102 |
| Pmpcb | -5714 | -7243 |
| Samm50 | -7217 | -6662 |
| Slc25a12 | -7001 | -7181 |
| Slc25a13 | -5896 | -6938 |
| Slc25a4 | -7089 | -7295 |
| Taz | -5545 | -5487 |
| Timm10 | -5933 | -5648 |
| Timm13 | -5069 | -2877 |
| Timm17a | -6452 | -6120 |
| Timm17b | -2372 | -4104 |
| Timm21 | -6376 | -7056 |
| Timm22 | -3823 | -5072 |
| Timm23 | -7335 | -7749 |
| Timm44 | -7154 | -7015 |
| Timm50 | -6322 | -5800 |
| Timm8b | -6609 | -6897 |
| Timm9 | -5723 | -5076 |
| Tomm20 | -4097 | -410 |
| Tomm22 | -5748 | -5300 |
| Tomm40 | -6658 | -5282 |
| Tomm6 | -3900 | -1449 |
| Tomm7 | -4071 | -4401 |
| Tomm70a | -5828 | -6506 |
| Vdac1 | -7008 | -7195 |
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 4.48e-21 |
| p.adjustMANOVA | 2.33e-20 |
| s.dist | 1.05 |
| s.young | -0.725 |
| s.old | -0.76 |
| p.young | 3.15e-19 |
| p.old | 5.37e-21 |
| Gene | young | old |
|---|---|---|
| Adhfe1 | -7349 | -7821 |
| Ldhb | -7348 | -7811 |
| Sdha | -7346 | -7813 |
| Sdhd | -7333 | -7791 |
| Sucla2 | -7292 | -7689 |
| Mpc2 | -7294 | -7670 |
| Suclg2 | -7193 | -7724 |
| Idh3b | -7322 | -7586 |
| Dld | -7216 | -7696 |
| Suclg1 | -7259 | -7645 |
| Dlst | -7165 | -7693 |
| Pdhx | -7172 | -7679 |
| Cs | -7238 | -7580 |
| Sdhb | -7295 | -7485 |
| Idh3a | -7085 | -7634 |
| Nnt | -6917 | -7798 |
| D2hgdh | -7104 | -7565 |
| Sdhc | -7227 | -7405 |
| Me3 | -7147 | -7472 |
| Fahd1 | -7052 | -7556 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Aco2 | -6436 | -6977 |
| Adhfe1 | -7349 | -7821 |
| Bsg | -6548 | -7267 |
| Cs | -7238 | -7580 |
| D2hgdh | -7104 | -7565 |
| Dlat | -7003 | -7332 |
| Dld | -7216 | -7696 |
| Dlst | -7165 | -7693 |
| Fahd1 | -7052 | -7556 |
| Fh1 | -7115 | -7449 |
| Glo1 | -5689 | -5454 |
| Gstz1 | -6066 | -6846 |
| Hagh | 3129 | -1329 |
| Idh2 | -6961 | -7381 |
| Idh3a | -7085 | -7634 |
| Idh3b | -7322 | -7586 |
| Idh3g | -7228 | -7314 |
| L2hgdh | -6879 | -7484 |
| Ldha | 3559 | -4312 |
| Ldhb | -7348 | -7811 |
| Mdh2 | -7233 | -7179 |
| Me1 | -6765 | -6942 |
| Me2 | 5856 | 4582 |
| Me3 | -7147 | -7472 |
| Mpc1 | -7043 | -7036 |
| Mpc2 | -7294 | -7670 |
| Nnt | -6917 | -7798 |
| Ogdh | -7013 | -7475 |
| Pdha1 | -7106 | -7283 |
| Pdhb | -7169 | -7319 |
| Pdhx | -7172 | -7679 |
| Pdk1 | 4156 | -6364 |
| Pdk2 | -6889 | -7055 |
| Pdk3 | 6805 | 6440 |
| Pdk4 | -1655 | 1645 |
| Pdp1 | -4181 | -5275 |
| Pdp2 | -5917 | -7570 |
| Pdpr | -5996 | -7506 |
| Ppard | -5588 | -4490 |
| Rxra | -6194 | -6804 |
| Sdha | -7346 | -7813 |
| Sdhb | -7295 | -7485 |
| Sdhc | -7227 | -7405 |
| Sdhd | -7333 | -7791 |
| Slc16a1 | -5936 | -4200 |
| Slc16a3 | 7305 | 6044 |
| Slc16a8 | -4482 | -3791 |
| Sucla2 | -7292 | -7689 |
| Suclg1 | -7259 | -7645 |
| Suclg2 | -7193 | -7724 |
| Vdac1 | -7008 | -7195 |
Mitochondrial-biogenesis
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 1.7e-19 |
| p.adjustMANOVA | 7.38e-19 |
| s.dist | 0.769 |
| s.young | -0.53 |
| s.old | -0.557 |
| p.young | 7.78e-18 |
| p.old | 1.67e-19 |
| Gene | young | old |
|---|---|---|
| Sod2 | -7345 | -7817 |
| Atp5o | -7347 | -7794 |
| Atp5l | -7340 | -7690 |
| Immt | -7219 | -7621 |
| Atp5pb | -7213 | -7607 |
| Atp5g3 | -7235 | -7573 |
| Atp5a1 | -7220 | -7504 |
| Atp5c1 | -7207 | -7515 |
| Hspa9 | -7037 | -7692 |
| Atp5h | -7284 | -7352 |
| Atp5j | -7206 | -7420 |
| Apoo | -7092 | -7482 |
| Atp5b | -7224 | -7258 |
| Cycs | -7133 | -7302 |
| Idh2 | -6961 | -7381 |
| mt-Atp6 | -7229 | -7101 |
| Chchd3 | -7066 | -7212 |
| Sirt5 | -6878 | -7374 |
| Atp5j2 | -7093 | -7135 |
| Ppara | -6545 | -7563 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acss2 | -2290 | -928 |
| Alas1 | -6613 | -7012 |
| Apoo | -7092 | -7482 |
| Apool | -5925 | -6704 |
| Atf2 | -651 | -5338 |
| Atp5a1 | -7220 | -7504 |
| Atp5b | -7224 | -7258 |
| Atp5c1 | -7207 | -7515 |
| Atp5d | -7173 | -6303 |
| Atp5e | -7150 | -6015 |
| Atp5g3 | -7235 | -7573 |
| Atp5h | -7284 | -7352 |
| Atp5j | -7206 | -7420 |
| Atp5j2 | -7093 | -7135 |
| Atp5k | -5830 | -7288 |
| Atp5l | -7340 | -7690 |
| Atp5o | -7347 | -7794 |
| Atp5pb | -7213 | -7607 |
| Calm1 | -4595 | -4970 |
| Carm1 | -1701 | -5594 |
| Chchd3 | -7066 | -7212 |
| Chchd6 | -3301 | -2838 |
| Chd9 | 6475 | 5594 |
| Creb1 | -3517 | -2558 |
| Crebbp | -3332 | -3533 |
| Crtc1 | 4822 | 3316 |
| Crtc2 | 2460 | 2533 |
| Crtc3 | 3593 | 2639 |
| Cycs | -7133 | -7302 |
| Dmac2l | -6520 | -7171 |
| Dnajc11 | -6412 | -6403 |
| Esrra | -6804 | -5371 |
| Gabpa | -3716 | -6288 |
| Gabpb1 | 856 | -2177 |
| Glud1 | -6306 | -7705 |
| Hcfc1 | -2259 | -3907 |
| Hdac3 | -6017 | -6749 |
| Helz2 | -4511 | 2213 |
| Hspa9 | -7037 | -7692 |
| Idh2 | -6961 | -7381 |
| Immt | -7219 | -7621 |
| Mapk11 | 704 | -262 |
| Mapk12 | 6483 | 6788 |
| Mapk14 | -6492 | -6835 |
| Med1 | -2830 | -5832 |
| Mef2c | 4484 | 1893 |
| Mef2d | -4176 | -241 |
| Micos10 | -7129 | -6291 |
| Micos13 | -6641 | -6011 |
| mt-Atp6 | -7229 | -7101 |
| mt-Atp8 | -3257 | -6724 |
| Mterf1a | 3165 | -425 |
| Mtx1 | -5805 | -4557 |
| Mtx2 | -6403 | -6945 |
| Ncoa1 | -4484 | -6419 |
| Ncoa2 | -3912 | -6801 |
| Ncoa6 | -1555 | -3479 |
| Ncor1 | -4730 | -6152 |
| Nr1d1 | 1296 | -175 |
| Nrf1 | 2046 | 1078 |
| Perm1 | -7027 | -6909 |
| Polg2 | -3186 | -2974 |
| Polrmt | -6292 | -5820 |
| Ppara | -6545 | -7563 |
| Ppargc1a | -6363 | -7511 |
| Ppargc1b | -5894 | -3355 |
| Pprc1 | 3621 | 3813 |
| Prkaa2 | -6100 | -7414 |
| Prkab1 | -4034 | -7255 |
| Prkab2 | 7420 | 5930 |
| Prkag1 | -6213 | -4030 |
| Prkag2 | 4029 | -2192 |
| Prkag3 | 5303 | 4957 |
| Rxra | -6194 | -6804 |
| Samm50 | -7217 | -6662 |
| Sirt3 | -6560 | -6988 |
| Sirt4 | -5710 | -5696 |
| Sirt5 | -6878 | -7374 |
| Smarcd3 | -4349 | -759 |
| Sod2 | -7345 | -7817 |
| Ssbp1 | -4608 | -3399 |
| Tbl1x | 3008 | -5102 |
| Tbl1xr1 | 4225 | -2715 |
| Tfam | -6212 | -6843 |
| Tfb1m | -3569 | -5783 |
| Tfb2m | -6600 | -7199 |
| Tgs1 | -4991 | -5508 |
| Tmem11 | -5461 | -4602 |
Mitochondrial-Fatty-Acid-Beta-Oxidation
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 5.13e-17 |
| p.adjustMANOVA | 1.91e-16 |
| s.dist | 1.21 |
| s.young | -0.858 |
| s.old | -0.85 |
| p.young | 1.25e-16 |
| p.old | 2.49e-16 |
| Gene | young | old |
|---|---|---|
| Hadh | -7309 | -7774 |
| Acaa2 | -7293 | -7768 |
| Eci1 | -7341 | -7716 |
| Hadhb | -7300 | -7759 |
| Acot2 | -7253 | -7797 |
| Decr1 | -7267 | -7777 |
| Echs1 | -7313 | -7662 |
| Hadha | -7254 | -7673 |
| Ndufab1 | -7247 | -7579 |
| Acad11 | -7134 | -7691 |
| Acadvl | -7306 | -7500 |
| Acadm | -7198 | -7598 |
| Mmut | -7065 | -7739 |
| Pcca | -7022 | -7738 |
| Mcee | -7015 | -7616 |
| Acads | -7280 | -7250 |
| Pccb | -7054 | -7359 |
| Acadl | -6920 | -7478 |
| Acot13 | -7060 | -7028 |
| Acot11 | -6459 | -7215 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acaa2 | -7293 | -7768 |
| Acad11 | -7134 | -7691 |
| Acad12 | -6749 | -6851 |
| Acadl | -6920 | -7478 |
| Acadm | -7198 | -7598 |
| Acads | -7280 | -7250 |
| Acadvl | -7306 | -7500 |
| Acbd6 | -5225 | -2979 |
| Acot11 | -6459 | -7215 |
| Acot13 | -7060 | -7028 |
| Acot2 | -7253 | -7797 |
| Acot7 | -5971 | -6960 |
| Acot9 | 7045 | 6582 |
| Acsf2 | -5910 | -7231 |
| Dbi | -6324 | -6808 |
| Decr1 | -7267 | -7777 |
| Echs1 | -7313 | -7662 |
| Eci1 | -7341 | -7716 |
| Hadh | -7309 | -7774 |
| Hadha | -7254 | -7673 |
| Hadhb | -7300 | -7759 |
| Mcat | -6474 | -6636 |
| Mcee | -7015 | -7616 |
| Mecr | -6170 | -6438 |
| Mmaa | -6691 | -6758 |
| Mmut | -7065 | -7739 |
| Ndufab1 | -7247 | -7579 |
| Pcca | -7022 | -7738 |
| Pccb | -7054 | -7359 |
| Pctp | -3512 | -6069 |
| Them4 | -5770 | -5601 |
Citric-acid-cycle-(TCA-cycle)
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 2.51e-13 |
| p.adjustMANOVA | 8.16e-13 |
| s.dist | 1.26 |
| s.young | -0.894 |
| s.old | -0.889 |
| p.young | 3.71e-13 |
| p.old | 5.02e-13 |
| Gene | young | old |
|---|---|---|
| Sdha | -7346 | -7813 |
| Sdhd | -7333 | -7791 |
| Sucla2 | -7292 | -7689 |
| Suclg2 | -7193 | -7724 |
| Idh3b | -7322 | -7586 |
| Dld | -7216 | -7696 |
| Suclg1 | -7259 | -7645 |
| Dlst | -7165 | -7693 |
| Cs | -7238 | -7580 |
| Sdhb | -7295 | -7485 |
| Idh3a | -7085 | -7634 |
| Nnt | -6917 | -7798 |
| Sdhc | -7227 | -7405 |
| Me3 | -7147 | -7472 |
| Fahd1 | -7052 | -7556 |
| Fh1 | -7115 | -7449 |
| Idh3g | -7228 | -7314 |
| Ogdh | -7013 | -7475 |
| Mdh2 | -7233 | -7179 |
| Idh2 | -6961 | -7381 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Aco2 | -6436 | -6977 |
| Cs | -7238 | -7580 |
| Dld | -7216 | -7696 |
| Dlst | -7165 | -7693 |
| Fahd1 | -7052 | -7556 |
| Fh1 | -7115 | -7449 |
| Idh2 | -6961 | -7381 |
| Idh3a | -7085 | -7634 |
| Idh3b | -7322 | -7586 |
| Idh3g | -7228 | -7314 |
| Mdh2 | -7233 | -7179 |
| Me2 | 5856 | 4582 |
| Me3 | -7147 | -7472 |
| Nnt | -6917 | -7798 |
| Ogdh | -7013 | -7475 |
| Sdha | -7346 | -7813 |
| Sdhb | -7295 | -7485 |
| Sdhc | -7227 | -7405 |
| Sdhd | -7333 | -7791 |
| Sucla2 | -7292 | -7689 |
| Suclg1 | -7259 | -7645 |
| Suclg2 | -7193 | -7724 |
rRNA-processing-in-the-mitochondrion
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 1.56e-11 |
| p.adjustMANOVA | 4.52e-11 |
| s.dist | 1.16 |
| s.young | -0.783 |
| s.old | -0.854 |
| p.young | 2e-10 |
| p.old | 3.93e-12 |
| Gene | young | old |
|---|---|---|
| mt-Co1 | -7257 | -7632 |
| mt-Nd2 | -7271 | -7495 |
| mt-Nd1 | -7119 | -7489 |
| mt-Cytb | -6947 | -7620 |
| Hsd17b10 | -6937 | -7410 |
| mt-Atp6 | -7229 | -7101 |
| mt-Co3 | -7307 | -7023 |
| Mrm2 | -6671 | -7643 |
| mt-Nd4 | -6682 | -7382 |
| mt-Nd5 | -6386 | -7564 |
| mt-Co2 | -7163 | -6523 |
| Nsun4 | -6285 | -7386 |
| Mrm3 | -6893 | -6717 |
| mt-Nd3 | -6642 | -5922 |
| Mterf4 | -5779 | -6241 |
| Trmt10c | -5141 | -6714 |
| mt-Nd4l | -3936 | -7494 |
| mt-Atp8 | -3257 | -6724 |
| Tfb1m | -3569 | -5783 |
| Mrm1 | -4507 | -4469 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Elac2 | -4160 | -4011 |
| Hsd17b10 | -6937 | -7410 |
| Mrm1 | -4507 | -4469 |
| Mrm2 | -6671 | -7643 |
| Mrm3 | -6893 | -6717 |
| mt-Atp6 | -7229 | -7101 |
| mt-Atp8 | -3257 | -6724 |
| mt-Co1 | -7257 | -7632 |
| mt-Co2 | -7163 | -6523 |
| mt-Co3 | -7307 | -7023 |
| mt-Cytb | -6947 | -7620 |
| mt-Nd1 | -7119 | -7489 |
| mt-Nd2 | -7271 | -7495 |
| mt-Nd3 | -6642 | -5922 |
| mt-Nd4 | -6682 | -7382 |
| mt-Nd4l | -3936 | -7494 |
| mt-Nd5 | -6386 | -7564 |
| Mterf4 | -5779 | -6241 |
| Nsun4 | -6285 | -7386 |
| Prorp | 1087 | -5691 |
| Tfb1m | -3569 | -5783 |
| Trmt10c | -5141 | -6714 |
Branched-chain-amino-acid-catabolism
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 5.85e-11 |
| p.adjustMANOVA | 1.52e-10 |
| s.dist | 1.22 |
| s.young | -0.859 |
| s.old | -0.871 |
| p.young | 9.04e-11 |
| p.old | 4.89e-11 |
| Gene | young | old |
|---|---|---|
| Bckdha | -7342 | -7803 |
| Hibadh | -7283 | -7717 |
| Acat1 | -7263 | -7711 |
| Dld | -7216 | -7696 |
| Mccc2 | -7174 | -7704 |
| Ivd | -7138 | -7712 |
| Aldh6a1 | -6998 | -7778 |
| Mccc1 | -6826 | -7722 |
| Bckdhb | -6907 | -7611 |
| Bcat2 | -6905 | -7609 |
| Auh | -6904 | -7596 |
| Ppm1k | -6684 | -7715 |
| Hsd17b10 | -6937 | -7410 |
| Dbt | -6615 | -7756 |
| Hibch | -6982 | -7198 |
| Acad8 | -6496 | -7039 |
| Acadsb | -5889 | -7297 |
| Bckdk | -6679 | -6373 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acad8 | -6496 | -7039 |
| Acadsb | -5889 | -7297 |
| Acat1 | -7263 | -7711 |
| Aldh6a1 | -6998 | -7778 |
| Auh | -6904 | -7596 |
| Bcat1 | 4700 | 5242 |
| Bcat2 | -6905 | -7609 |
| Bckdha | -7342 | -7803 |
| Bckdhb | -6907 | -7611 |
| Bckdk | -6679 | -6373 |
| Dbt | -6615 | -7756 |
| Dld | -7216 | -7696 |
| Hibadh | -7283 | -7717 |
| Hibch | -6982 | -7198 |
| Hsd17b10 | -6937 | -7410 |
| Ivd | -7138 | -7712 |
| Mccc1 | -6826 | -7722 |
| Mccc2 | -7174 | -7704 |
| Ppm1k | -6684 | -7715 |
Mitochondrial-tRNA-aminoacylation
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 3.66e-08 |
| p.adjustMANOVA | 8.37e-08 |
| s.dist | 1.04 |
| s.young | -0.756 |
| s.old | -0.712 |
| p.young | 1.14e-08 |
| p.old | 7.59e-08 |
| Gene | young | old |
|---|---|---|
| Fars2 | -6885 | -7333 |
| Sars2 | -6953 | -6965 |
| Nars2 | -6694 | -7073 |
| Ppa2 | -6676 | -6918 |
| Vars2 | -6968 | -6459 |
| Cars2 | -6673 | -6550 |
| Yars2 | -6001 | -7155 |
| Iars2 | -5691 | -7099 |
| Aars2 | -6224 | -6392 |
| Hars2 | -5875 | -6761 |
| Dars2 | -5581 | -7062 |
| Tars2 | -6442 | -5956 |
| Mars2 | -5106 | -7011 |
| Rars2 | -5676 | -5759 |
| Wars2 | -4658 | -5948 |
| Pars2 | -3576 | -3342 |
| Ears2 | -1578 | -3330 |
| Lars2 | -6814 | -414 |
| Kars | -1031 | -313 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Aars2 | -6224 | -6392 |
| Cars2 | -6673 | -6550 |
| Dars2 | -5581 | -7062 |
| Ears2 | -1578 | -3330 |
| Fars2 | -6885 | -7333 |
| Hars2 | -5875 | -6761 |
| Iars2 | -5691 | -7099 |
| Kars | -1031 | -313 |
| Lars2 | -6814 | -414 |
| Mars2 | -5106 | -7011 |
| Nars2 | -6694 | -7073 |
| Pars2 | -3576 | -3342 |
| Ppa2 | -6676 | -6918 |
| Rars2 | -5676 | -5759 |
| Sars2 | -6953 | -6965 |
| Tars2 | -6442 | -5956 |
| Vars2 | -6968 | -6459 |
| Wars2 | -4658 | -5948 |
| Yars2 | -6001 | -7155 |
Transcriptional-activation-of-mitochondrial-biogenesis
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 3.86e-08 |
| p.adjustMANOVA | 8.37e-08 |
| s.dist | 0.628 |
| s.young | -0.418 |
| s.old | -0.468 |
| p.young | 2.43e-07 |
| p.old | 7.23e-09 |
| Gene | young | old |
|---|---|---|
| Sod2 | -7345 | -7817 |
| Atp5b | -7224 | -7258 |
| Cycs | -7133 | -7302 |
| Idh2 | -6961 | -7381 |
| Sirt5 | -6878 | -7374 |
| Ppara | -6545 | -7563 |
| Glud1 | -6306 | -7705 |
| Perm1 | -7027 | -6909 |
| Ppargc1a | -6363 | -7511 |
| Tfb2m | -6600 | -7199 |
| Alas1 | -6613 | -7012 |
| Sirt3 | -6560 | -6988 |
| Tfam | -6212 | -6843 |
| Rxra | -6194 | -6804 |
| Hdac3 | -6017 | -6749 |
| Polrmt | -6292 | -5820 |
| Esrra | -6804 | -5371 |
| Sirt4 | -5710 | -5696 |
| Ncor1 | -4730 | -6152 |
| Ncoa1 | -4484 | -6419 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acss2 | -2290 | -928 |
| Alas1 | -6613 | -7012 |
| Atf2 | -651 | -5338 |
| Atp5b | -7224 | -7258 |
| Calm1 | -4595 | -4970 |
| Carm1 | -1701 | -5594 |
| Chd9 | 6475 | 5594 |
| Creb1 | -3517 | -2558 |
| Crebbp | -3332 | -3533 |
| Crtc1 | 4822 | 3316 |
| Crtc2 | 2460 | 2533 |
| Crtc3 | 3593 | 2639 |
| Cycs | -7133 | -7302 |
| Esrra | -6804 | -5371 |
| Gabpa | -3716 | -6288 |
| Gabpb1 | 856 | -2177 |
| Glud1 | -6306 | -7705 |
| Hcfc1 | -2259 | -3907 |
| Hdac3 | -6017 | -6749 |
| Helz2 | -4511 | 2213 |
| Idh2 | -6961 | -7381 |
| Med1 | -2830 | -5832 |
| Mef2c | 4484 | 1893 |
| Mef2d | -4176 | -241 |
| Mterf1a | 3165 | -425 |
| Ncoa1 | -4484 | -6419 |
| Ncoa2 | -3912 | -6801 |
| Ncoa6 | -1555 | -3479 |
| Ncor1 | -4730 | -6152 |
| Nr1d1 | 1296 | -175 |
| Nrf1 | 2046 | 1078 |
| Perm1 | -7027 | -6909 |
| Polg2 | -3186 | -2974 |
| Polrmt | -6292 | -5820 |
| Ppara | -6545 | -7563 |
| Ppargc1a | -6363 | -7511 |
| Ppargc1b | -5894 | -3355 |
| Pprc1 | 3621 | 3813 |
| Rxra | -6194 | -6804 |
| Sirt3 | -6560 | -6988 |
| Sirt4 | -5710 | -5696 |
| Sirt5 | -6878 | -7374 |
| Smarcd3 | -4349 | -759 |
| Sod2 | -7345 | -7817 |
| Ssbp1 | -4608 | -3399 |
| Tbl1x | 3008 | -5102 |
| Tbl1xr1 | 4225 | -2715 |
| Tfam | -6212 | -6843 |
| Tfb1m | -3569 | -5783 |
| Tfb2m | -6600 | -7199 |
| Tgs1 | -4991 | -5508 |
Mitochondrial-iron-sulfur-cluster-biogenesis
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 6.99e-05 |
| p.adjustMANOVA | 0.00014 |
| s.dist | 1.07 |
| s.young | -0.741 |
| s.old | -0.775 |
| p.young | 4.95e-05 |
| p.old | 2.19e-05 |
| Gene | young | old |
|---|---|---|
| Nfs1 | -7331 | -7674 |
| Isca1 | -7123 | -7445 |
| Isca2 | -6619 | -6949 |
| Fdx1 | -6618 | -6735 |
| Fxn | -6784 | -6569 |
| Iscu | -5913 | -6379 |
| Glrx5 | -6203 | -4666 |
| Slc25a37 | -2322 | -5900 |
| Slc25a28 | -3690 | -3434 |
| Hscb | -1609 | -5700 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Fdx1 | -6618 | -6735 |
| Fxn | -6784 | -6569 |
| Glrx5 | -6203 | -4666 |
| Hscb | -1609 | -5700 |
| Isca1 | -7123 | -7445 |
| Isca2 | -6619 | -6949 |
| Iscu | -5913 | -6379 |
| Nfs1 | -7331 | -7674 |
| Slc25a28 | -3690 | -3434 |
| Slc25a37 | -2322 | -5900 |
Mitochondrial-calcium-ion-transport
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 0.000153 |
| p.adjustMANOVA | 0.000284 |
| s.dist | 0.71 |
| s.young | -0.495 |
| s.old | -0.509 |
| p.young | 8.64e-05 |
| p.old | 5.32e-05 |
| Gene | young | old |
|---|---|---|
| Phb | -7148 | -7279 |
| Vdac1 | -7008 | -7195 |
| Vdac3 | -6938 | -7147 |
| Afg3l2 | -6709 | -7174 |
| Pmpca | -6712 | -7102 |
| Parl | -6531 | -7264 |
| Phb2 | -7196 | -6457 |
| Vdac2 | -6648 | -6666 |
| Letm1 | -6685 | -6378 |
| Spg7 | -6831 | -6169 |
| Pmpcb | -5714 | -7243 |
| Akap1 | -5651 | -6902 |
| Stoml2 | -6275 | -5665 |
| Yme1l1 | -1988 | -4374 |
| Smdt1 | -1291 | -178 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Afg3l2 | -6709 | -7174 |
| Akap1 | -5651 | -6902 |
| Letm1 | -6685 | -6378 |
| Mcu | 2029 | -3493 |
| Mcub | 1688 | 607 |
| Micu1 | 4070 | 2942 |
| Micu2 | 6554 | 5473 |
| Micu3 | 411 | -871 |
| Parl | -6531 | -7264 |
| Phb | -7148 | -7279 |
| Phb2 | -7196 | -6457 |
| Pmpca | -6712 | -7102 |
| Pmpcb | -5714 | -7243 |
| Slc8b1 | -796 | 1010 |
| Smdt1 | -1291 | -178 |
| Spg7 | -6831 | -6169 |
| Stoml2 | -6275 | -5665 |
| Vdac1 | -7008 | -7195 |
| Vdac2 | -6648 | -6666 |
| Vdac3 | -6938 | -7147 |
| Yme1l1 | -1988 | -4374 |
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha
| metric | value |
|---|---|
| setSize | 60 |
| pMANOVA | 0.00046 |
| p.adjustMANOVA | 0.000797 |
| s.dist | 0.323 |
| s.young | -0.276 |
| s.old | -0.167 |
| p.young | 0.000217 |
| p.old | 0.0257 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Egln1 | -6444 | -7403 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Epas1 | -5094 | -7186 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Ube2d1 | -4576 | -5721 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Egln3 | -3770 | -5817 |
| Rbx1 | -4743 | -4554 |
| Cul2 | -3785 | -5613 |
| Psmc3 | -5727 | -3198 |
| Eloc | -3360 | -5140 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ajuba | 4368 | 1241 |
| Cul2 | -3785 | -5613 |
| Egln1 | -6444 | -7403 |
| Egln2 | -4422 | -46 |
| Egln3 | -3770 | -5817 |
| Eloc | -3360 | -5140 |
| Epas1 | -5094 | -7186 |
| Gm11808 | -5706 | -216 |
| Hif1a | 6604 | 1121 |
| Hif3a | -2849 | -3750 |
| Limd1 | 5384 | 3308 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rbx1 | -4743 | -4554 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Ube2d1 | -4576 | -5721 |
| Ube2d2a | -681 | -3716 |
| Ube2d3 | 5709 | 3978 |
| Wtip | 5076 | 4967 |
Cellular-response-to-hypoxia
| metric | value |
|---|---|
| setSize | 68 |
| pMANOVA | 0.000897 |
| p.adjustMANOVA | 0.00146 |
| s.dist | 0.29 |
| s.young | -0.248 |
| s.old | -0.15 |
| p.young | 0.00041 |
| p.old | 0.0331 |
| Gene | young | old |
|---|---|---|
| Psme1 | -7082 | -7176 |
| Egln1 | -6444 | -7403 |
| Vegfa | -6273 | -7378 |
| Higd1a | -5965 | -7009 |
| Psmb2 | -6229 | -6389 |
| Psmb7 | -6295 | -6022 |
| Epas1 | -5094 | -7186 |
| Psmd12 | -5949 | -6045 |
| Psme4 | -5860 | -5252 |
| Psmb3 | -6394 | -4507 |
| Psmb6 | -5905 | -4631 |
| Psma6 | -6198 | -4392 |
| Psma1 | -5057 | -5354 |
| Ube2d1 | -4576 | -5721 |
| Psmc2 | -5438 | -4371 |
| Psme3 | -4430 | -5111 |
| Psma4 | -4195 | -5256 |
| Egln3 | -3770 | -5817 |
| Rbx1 | -4743 | -4554 |
| Cul2 | -3785 | -5613 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Ajuba | 4368 | 1241 |
| Arnt | 5880 | 5777 |
| Car9 | 6540 | 6683 |
| Cited2 | 6879 | 5555 |
| Crebbp | -3332 | -3533 |
| Cul2 | -3785 | -5613 |
| Egln1 | -6444 | -7403 |
| Egln2 | -4422 | -46 |
| Egln3 | -3770 | -5817 |
| Eloc | -3360 | -5140 |
| Ep300 | -2809 | -454 |
| Epas1 | -5094 | -7186 |
| Gm11808 | -5706 | -216 |
| Hif1a | 6604 | 1121 |
| Hif1an | -2304 | -3962 |
| Hif3a | -2849 | -3750 |
| Higd1a | -5965 | -7009 |
| Limd1 | 5384 | 3308 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Rbx1 | -4743 | -4554 |
| Rps27a | -1504 | -1029 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Ube2d1 | -4576 | -5721 |
| Ube2d2a | -681 | -3716 |
| Ube2d3 | 5709 | 3978 |
| Vegfa | -6273 | -7378 |
| Wtip | 5076 | 4967 |
Smooth-Muscle-Contraction
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 0.00921 |
| p.adjustMANOVA | 0.0141 |
| s.dist | 0.213 |
| s.young | 0.0314 |
| s.old | 0.211 |
| p.young | 0.762 |
| p.old | 0.0421 |
| Gene | young | old |
|---|---|---|
| Tpm2 | 7506 | 6955 |
| Anxa2 | 6945 | 6847 |
| Anxa1 | 7137 | 6423 |
| Itgb5 | 7035 | 6117 |
| Tln1 | 6888 | 5990 |
| Sorbs3 | 5997 | 6450 |
| Cald1 | 6283 | 5671 |
| Myl12a | 5669 | 5304 |
| Anxa6 | 5722 | 2604 |
| Pak1 | 3769 | 3862 |
| Tpm3 | 3419 | 4092 |
| Dysf | 1616 | 5692 |
| Myl6b | 569 | 5006 |
| Vcl | 879 | 1982 |
| Myl12b | 844 | 518 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acta2 | -5838 | 3002 |
| Actg2 | -2377 | -637 |
| Anxa1 | 7137 | 6423 |
| Anxa2 | 6945 | 6847 |
| Anxa6 | 5722 | 2604 |
| Cald1 | 6283 | 5671 |
| Calm1 | -4595 | -4970 |
| Cav3 | -6028 | -3293 |
| Dysf | 1616 | 5692 |
| Gucy1a2 | -2952 | -4419 |
| Itga1 | -2422 | -3850 |
| Itgb5 | 7035 | 6117 |
| Lmod1 | -1775 | 2083 |
| Myh11 | -4929 | -1359 |
| Myl12a | 5669 | 5304 |
| Myl12b | 844 | 518 |
| Myl6b | 569 | 5006 |
| Myl7 | -4553 | 1587 |
| Myl9 | -1361 | -776 |
| Mylk | -6527 | -5002 |
| Pak1 | 3769 | 3862 |
| Pak2 | 1636 | -1595 |
| Pxn | -1407 | -2587 |
| Sorbs1 | -5262 | -5248 |
| Sorbs3 | 5997 | 6450 |
| Tln1 | 6888 | 5990 |
| Tpm1 | -6913 | -5352 |
| Tpm2 | 7506 | 6955 |
| Tpm3 | 3419 | 4092 |
| Trim72 | -5043 | -4443 |
| Vcl | 879 | 1982 |
Glycolysis
| metric | value |
|---|---|
| setSize | 63 |
| pMANOVA | 0.0143 |
| p.adjustMANOVA | 0.0207 |
| s.dist | 0.236 |
| s.young | -0.124 |
| s.old | -0.201 |
| p.young | 0.0898 |
| p.old | 0.00571 |
| Gene | young | old |
|---|---|---|
| Eno3 | -7068 | -7520 |
| Hk2 | -6466 | -7376 |
| Pfkm | -6806 | -6837 |
| Aldoa | -6760 | -6877 |
| Pgam2 | -6840 | -6595 |
| Pfkfb1 | -5631 | -7672 |
| Nup210 | -5985 | -6834 |
| Pkm | -5840 | -6250 |
| Prkaca | -6075 | -5990 |
| Nup62 | -5422 | -4685 |
| Pgp | -5202 | -4673 |
| Ppp2r1a | -5112 | -3845 |
| Ndc1 | -3676 | -4825 |
| Pgm2l1 | -3658 | -4003 |
| Tpi1 | -2612 | -5131 |
| Nupl2 | -3657 | -3335 |
| Pom121 | -5732 | -2088 |
| Bpgm | -2698 | -3560 |
| Ppp2r5d | -3601 | -2560 |
| Nup88 | -1840 | -4528 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Aaas | -621 | 4067 |
| Adpgk | 4874 | 6241 |
| Aldoa | -6760 | -6877 |
| Aldob | -4396 | -1794 |
| Bpgm | -2698 | -3560 |
| Eno2 | 5951 | 5994 |
| Eno3 | -7068 | -7520 |
| Gapdhs | -2761 | 375 |
| Gck | 6897 | 4422 |
| Gm49336 | 3826 | 3163 |
| Gnpda1 | -60 | -2955 |
| Gnpda2 | -899 | -1019 |
| Gpi1 | 729 | -2017 |
| Hk1 | -573 | 1353 |
| Hk2 | -6466 | -7376 |
| Hk3 | 116 | -817 |
| Ndc1 | -3676 | -4825 |
| Nup107 | -1252 | -1977 |
| Nup133 | -2488 | -1920 |
| Nup153 | 608 | 1264 |
| Nup155 | 3051 | 361 |
| Nup160 | 2576 | 936 |
| Nup188 | 1219 | 1677 |
| Nup205 | -670 | -3324 |
| Nup210 | -5985 | -6834 |
| Nup214 | -1565 | -479 |
| Nup35 | 1447 | -1156 |
| Nup37 | -326 | -4277 |
| Nup43 | -462 | -1511 |
| Nup50 | -566 | -2471 |
| Nup54 | -939 | -4619 |
| Nup62 | -5422 | -4685 |
| Nup85 | -2481 | -84 |
| Nup88 | -1840 | -4528 |
| Nup93 | 4359 | 4421 |
| Nup98 | 3276 | -3680 |
| Nupl2 | -3657 | -3335 |
| Pfkfb1 | -5631 | -7672 |
| Pfkfb3 | 5566 | 2556 |
| Pfkfb4 | 1327 | 920 |
| Pfkl | 2644 | -5278 |
| Pfkm | -6806 | -6837 |
| Pfkp | 6325 | 6660 |
| Pgam1 | -1039 | -4657 |
| Pgam2 | -6840 | -6595 |
| Pgk1 | 1605 | -5844 |
| Pgm2l1 | -3658 | -4003 |
| Pgp | -5202 | -4673 |
| Pkm | -5840 | -6250 |
| Pom121 | -5732 | -2088 |
| Ppp2ca | 1302 | 1549 |
| Ppp2cb | 2162 | -1862 |
| Ppp2r1a | -5112 | -3845 |
| Ppp2r1b | -1090 | -2605 |
| Ppp2r5d | -3601 | -2560 |
| Prkaca | -6075 | -5990 |
| Prkacb | 3875 | -3919 |
| Rae1 | -2439 | -1886 |
| Ranbp2 | 1943 | -1227 |
| Sec13 | 1575 | 39 |
| Seh1l | 326 | -1812 |
| Tpi1 | -2612 | -5131 |
| Tpr | 5510 | 4178 |
Signaling-by-Hippo
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.0154 |
| p.adjustMANOVA | 0.0211 |
| s.dist | 0.484 |
| s.young | 0.373 |
| s.old | 0.309 |
| p.young | 0.00388 |
| p.old | 0.0167 |
| Gene | young | old |
|---|---|---|
| Stk4 | 7525 | 7053 |
| Tjp2 | 6209 | 6194 |
| Amot | 6138 | 5596 |
| Casp3 | 6837 | 4230 |
| Yap1 | 5991 | 4386 |
| Lats1 | 5607 | 4503 |
| Wwtr1 | 4739 | 5130 |
| Sav1 | 5451 | 4022 |
| Nphp4 | 4269 | 3539 |
| Mob1b | 3081 | 4724 |
| Stk3 | 3645 | 3649 |
| Mob1a | 4148 | 2195 |
| Amotl1 | 838 | 4479 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Amot | 6138 | 5596 |
| Amotl1 | 838 | 4479 |
| Amotl2 | -5325 | -5232 |
| Casp3 | 6837 | 4230 |
| Dvl2 | 5014 | -1883 |
| Lats1 | 5607 | 4503 |
| Lats2 | -1646 | -797 |
| Mob1a | 4148 | 2195 |
| Mob1b | 3081 | 4724 |
| Nphp4 | 4269 | 3539 |
| Sav1 | 5451 | 4022 |
| Stk3 | 3645 | 3649 |
| Stk4 | 7525 | 7053 |
| Tjp1 | -3710 | -5609 |
| Tjp2 | 6209 | 6194 |
| Wwc1 | 2276 | -247 |
| Wwtr1 | 4739 | 5130 |
| Yap1 | 5991 | 4386 |
| Ywhab | 1382 | -1493 |
| Ywhae | -5312 | -6195 |
Muscle-contraction
| metric | value |
|---|---|
| setSize | 148 |
| pMANOVA | 0.0298 |
| p.adjustMANOVA | 0.0387 |
| s.dist | 0.0555 |
| s.young | -0.0438 |
| s.old | 0.0341 |
| p.young | 0.359 |
| p.old | 0.474 |
| Gene | young | old |
|---|---|---|
| Acta2 | -5838 | 3002 |
| Cacna2d3 | -2618 | 5379 |
| Myl4 | -4427 | 2909 |
| Cacnb4 | -1978 | 6296 |
| Itpr2 | -1813 | 4665 |
| Fgf12 | -4127 | 1964 |
| Myl7 | -4553 | 1587 |
| Itpr1 | -3696 | 1181 |
| Hipk1 | -831 | 5084 |
| Lmod1 | -1775 | 2083 |
| Atp1b1 | -1204 | 2783 |
| Asph | -1819 | 1114 |
| Atp2a3 | -769 | 2193 |
| Itpr3 | -366 | 4557 |
| Tmod1 | -378 | 3179 |
| Orai1 | -391 | 2719 |
| Cacna2d2 | -232 | 3850 |
| Trpc1 | -49 | 3374 |
| Atp2b4 | -6 | 420 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abcc9 | -6853 | -7721 |
| Acta2 | -5838 | 3002 |
| Actg2 | -2377 | -637 |
| Actn2 | -2000 | -1053 |
| Ahcyl1 | 366 | -4646 |
| Akap9 | 4058 | 435 |
| Anxa1 | 7137 | 6423 |
| Anxa2 | 6945 | 6847 |
| Anxa6 | 5722 | 2604 |
| Asph | -1819 | 1114 |
| Atp1a1 | -6556 | -6452 |
| Atp1a2 | -4140 | -3563 |
| Atp1b1 | -1204 | 2783 |
| Atp1b2 | -2601 | -6512 |
| Atp1b3 | 4548 | 186 |
| Atp2a2 | -6892 | -7466 |
| Atp2a3 | -769 | 2193 |
| Atp2b1 | 4820 | 5361 |
| Atp2b2 | -3158 | -3849 |
| Atp2b4 | -6 | 420 |
| Cacna1c | -3035 | -6072 |
| Cacna1d | -368 | -2755 |
| Cacna1s | -4701 | -5602 |
| Cacna2d1 | 2938 | 1584 |
| Cacna2d2 | -232 | 3850 |
| Cacna2d3 | -2618 | 5379 |
| Cacnb1 | 7379 | 6564 |
| Cacnb2 | -5371 | -6792 |
| Cacnb3 | 6991 | 5679 |
| Cacnb4 | -1978 | 6296 |
| Cacng6 | -3075 | -7038 |
| Cacng7 | 5352 | 4357 |
| Cald1 | 6283 | 5671 |
| Calm1 | -4595 | -4970 |
| Camk2a | -6445 | -7293 |
| Camk2b | 7071 | 5898 |
| Camk2g | -3829 | -6080 |
| Cav3 | -6028 | -3293 |
| Corin | -1532 | -173 |
| Des | 7479 | 6672 |
| Dmd | 6489 | 6319 |
| Dmpk | -6621 | -3668 |
| Dysf | 1616 | 5692 |
| Fgf11 | 885 | -1941 |
| Fgf12 | -4127 | 1964 |
| Fgf14 | 4114 | 4000 |
| Fxyd1 | -3088 | -2453 |
| Fxyd2 | -5926 | -343 |
| Fxyd3 | 1436 | 3210 |
| Fxyd6 | 6695 | 6230 |
| Gata4 | -1370 | -4005 |
| Gucy1a2 | -2952 | -4419 |
| Hipk1 | -831 | 5084 |
| Hipk2 | 6736 | 4300 |
| Itga1 | -2422 | -3850 |
| Itgb5 | 7035 | 6117 |
| Itpr1 | -3696 | 1181 |
| Itpr2 | -1813 | 4665 |
| Itpr3 | -366 | 4557 |
| Kat2b | 316 | -3888 |
| Kcnd1 | 6203 | 3591 |
| Kcnd2 | -6717 | -7280 |
| Kcnd3 | -6833 | -7605 |
| Kcne1 | -6188 | -3656 |
| Kcne4 | 3881 | 3309 |
| Kcnh2 | -4514 | -4097 |
| Kcnip2 | -7304 | -7769 |
| Kcnip3 | 5269 | 221 |
| Kcnj11 | -6582 | -5269 |
| Kcnj12 | -1474 | -1008 |
| Kcnj14 | 5891 | 5935 |
| Kcnj2 | -6095 | -6998 |
| Kcnk10 | 6513 | 6484 |
| Kcnk13 | -2018 | -22 |
| Kcnk2 | 7333 | 6765 |
| Kcnk3 | -6040 | -5964 |
| Kcnk5 | 3870 | 3144 |
| Kcnk6 | -1027 | -373 |
| Kcnq1 | -5345 | -5178 |
| Lmod1 | -1775 | 2083 |
| Mybpc2 | 6998 | 3417 |
| Mybpc3 | -3275 | -1070 |
| Myh11 | -4929 | -1359 |
| Myh6 | -5096 | -3804 |
| Myl1 | 5238 | 5447 |
| Myl12a | 5669 | 5304 |
| Myl12b | 844 | 518 |
| Myl2 | -7018 | -6999 |
| Myl3 | -7167 | -7092 |
| Myl4 | -4427 | 2909 |
| Myl6b | 569 | 5006 |
| Myl7 | -4553 | 1587 |
| Myl9 | -1361 | -776 |
| Mylk | -6527 | -5002 |
| Neb | 7054 | 6943 |
| Nkx2-5 | -4566 | -2772 |
| Nppa | 7523 | 7032 |
| Npr1 | -1933 | -2295 |
| Npr2 | 274 | 1535 |
| Orai1 | -391 | 2719 |
| Orai2 | 6641 | 5516 |
| Pak1 | 3769 | 3862 |
| Pak2 | 1636 | -1595 |
| Pln | -6822 | -7221 |
| Prkaca | -6075 | -5990 |
| Pxn | -1407 | -2587 |
| Rangrf | -7025 | -6496 |
| Ryr2 | -4136 | -7447 |
| Ryr3 | 7066 | 7043 |
| Scn10a | -1780 | -5635 |
| Scn1b | 7287 | 5698 |
| Scn2a | 1958 | 3825 |
| Scn2b | 2702 | 363 |
| Scn3a | -2558 | -4406 |
| Scn3b | -1741 | -3869 |
| Scn4a | -7014 | -7787 |
| Scn4b | -5641 | -7810 |
| Scn5a | -3090 | -3687 |
| Scn7a | 5696 | 3823 |
| Slc8a1 | 218 | -5590 |
| Slc8a2 | 3713 | 4013 |
| Sorbs1 | -5262 | -5248 |
| Sorbs3 | 5997 | 6450 |
| Sri | 2679 | -2417 |
| Stim1 | 2993 | -3965 |
| Tbx5 | -4975 | -6190 |
| Tcap | 1037 | 1482 |
| Tln1 | 6888 | 5990 |
| Tmod1 | -378 | 3179 |
| Tmod2 | 6815 | 6490 |
| Tmod3 | 2559 | 4280 |
| Tmod4 | -7023 | -7652 |
| Tnnc1 | 1039 | -2228 |
| Tnni1 | 7440 | 4841 |
| Tnni3 | -7252 | -7418 |
| Tnnt1 | -5113 | -5807 |
| Tnnt2 | -5534 | -6184 |
| Tnnt3 | 6858 | 5227 |
| Tpm1 | -6913 | -5352 |
| Tpm2 | 7506 | 6955 |
| Tpm3 | 3419 | 4092 |
| Trdn | -1037 | -3952 |
| Trim72 | -5043 | -4443 |
| Trpc1 | -49 | 3374 |
| Ttn | 1202 | 4051 |
| Vcl | 879 | 1982 |
| Vim | 7124 | 6031 |
| Wwtr1 | 4739 | 5130 |
Cardiac-conduction
| metric | value |
|---|---|
| setSize | 95 |
| pMANOVA | 0.152 |
| p.adjustMANOVA | 0.188 |
| s.dist | 0.132 |
| s.young | -0.111 |
| s.old | -0.0714 |
| p.young | 0.0617 |
| p.old | 0.229 |
| Gene | young | old |
|---|---|---|
| Kcnip2 | -7304 | -7769 |
| Scn4a | -7014 | -7787 |
| Tnni3 | -7252 | -7418 |
| Abcc9 | -6853 | -7721 |
| Kcnd3 | -6833 | -7605 |
| Atp2a2 | -6892 | -7466 |
| Pln | -6822 | -7221 |
| Kcnd2 | -6717 | -7280 |
| Camk2a | -6445 | -7293 |
| Rangrf | -7025 | -6496 |
| Scn4b | -5641 | -7810 |
| Kcnj2 | -6095 | -6998 |
| Atp1a1 | -6556 | -6452 |
| Cacnb2 | -5371 | -6792 |
| Prkaca | -6075 | -5990 |
| Kcnk3 | -6040 | -5964 |
| Kcnj11 | -6582 | -5269 |
| Ryr2 | -4136 | -7447 |
| Tbx5 | -4975 | -6190 |
| Kcnq1 | -5345 | -5178 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abcc9 | -6853 | -7721 |
| Ahcyl1 | 366 | -4646 |
| Akap9 | 4058 | 435 |
| Asph | -1819 | 1114 |
| Atp1a1 | -6556 | -6452 |
| Atp1a2 | -4140 | -3563 |
| Atp1b1 | -1204 | 2783 |
| Atp1b2 | -2601 | -6512 |
| Atp1b3 | 4548 | 186 |
| Atp2a2 | -6892 | -7466 |
| Atp2a3 | -769 | 2193 |
| Atp2b1 | 4820 | 5361 |
| Atp2b2 | -3158 | -3849 |
| Atp2b4 | -6 | 420 |
| Cacna1c | -3035 | -6072 |
| Cacna1d | -368 | -2755 |
| Cacna1s | -4701 | -5602 |
| Cacna2d1 | 2938 | 1584 |
| Cacna2d2 | -232 | 3850 |
| Cacna2d3 | -2618 | 5379 |
| Cacnb1 | 7379 | 6564 |
| Cacnb2 | -5371 | -6792 |
| Cacnb3 | 6991 | 5679 |
| Cacnb4 | -1978 | 6296 |
| Cacng6 | -3075 | -7038 |
| Cacng7 | 5352 | 4357 |
| Calm1 | -4595 | -4970 |
| Camk2a | -6445 | -7293 |
| Camk2b | 7071 | 5898 |
| Camk2g | -3829 | -6080 |
| Corin | -1532 | -173 |
| Dmpk | -6621 | -3668 |
| Fgf11 | 885 | -1941 |
| Fgf12 | -4127 | 1964 |
| Fgf14 | 4114 | 4000 |
| Fxyd1 | -3088 | -2453 |
| Fxyd2 | -5926 | -343 |
| Fxyd3 | 1436 | 3210 |
| Fxyd6 | 6695 | 6230 |
| Gata4 | -1370 | -4005 |
| Hipk1 | -831 | 5084 |
| Hipk2 | 6736 | 4300 |
| Itpr1 | -3696 | 1181 |
| Itpr2 | -1813 | 4665 |
| Itpr3 | -366 | 4557 |
| Kat2b | 316 | -3888 |
| Kcnd1 | 6203 | 3591 |
| Kcnd2 | -6717 | -7280 |
| Kcnd3 | -6833 | -7605 |
| Kcne1 | -6188 | -3656 |
| Kcne4 | 3881 | 3309 |
| Kcnh2 | -4514 | -4097 |
| Kcnip2 | -7304 | -7769 |
| Kcnip3 | 5269 | 221 |
| Kcnj11 | -6582 | -5269 |
| Kcnj12 | -1474 | -1008 |
| Kcnj14 | 5891 | 5935 |
| Kcnj2 | -6095 | -6998 |
| Kcnk10 | 6513 | 6484 |
| Kcnk13 | -2018 | -22 |
| Kcnk2 | 7333 | 6765 |
| Kcnk3 | -6040 | -5964 |
| Kcnk5 | 3870 | 3144 |
| Kcnk6 | -1027 | -373 |
| Kcnq1 | -5345 | -5178 |
| Nkx2-5 | -4566 | -2772 |
| Nppa | 7523 | 7032 |
| Npr1 | -1933 | -2295 |
| Npr2 | 274 | 1535 |
| Orai1 | -391 | 2719 |
| Orai2 | 6641 | 5516 |
| Pln | -6822 | -7221 |
| Prkaca | -6075 | -5990 |
| Rangrf | -7025 | -6496 |
| Ryr2 | -4136 | -7447 |
| Ryr3 | 7066 | 7043 |
| Scn10a | -1780 | -5635 |
| Scn1b | 7287 | 5698 |
| Scn2a | 1958 | 3825 |
| Scn2b | 2702 | 363 |
| Scn3a | -2558 | -4406 |
| Scn3b | -1741 | -3869 |
| Scn4a | -7014 | -7787 |
| Scn4b | -5641 | -7810 |
| Scn5a | -3090 | -3687 |
| Scn7a | 5696 | 3823 |
| Slc8a1 | 218 | -5590 |
| Slc8a2 | 3713 | 4013 |
| Sri | 2679 | -2417 |
| Stim1 | 2993 | -3965 |
| Tbx5 | -4975 | -6190 |
| Tnni3 | -7252 | -7418 |
| Trdn | -1037 | -3952 |
| Trpc1 | -49 | 3374 |
| Wwtr1 | 4739 | 5130 |
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.272 |
| p.adjustMANOVA | 0.321 |
| s.dist | 0.173 |
| s.young | 0.00972 |
| s.old | 0.173 |
| p.young | 0.955 |
| p.old | 0.321 |
| Gene | young | old |
|---|---|---|
| Trp53 | 4978 | 4881 |
| Birc5 | 2583 | 4194 |
| Trp63 | 2314 | 3879 |
| Chm | 4576 | 910 |
| Bcl6 | 1508 | 2136 |
| Trp53bp2 | 2617 | 1007 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Bcl6 | 1508 | 2136 |
| Birc5 | 2583 | 4194 |
| Chm | 4576 | 910 |
| Ndrg1 | -3711 | -2364 |
| Perp | -469 | 2369 |
| Ppp1r13b | -4238 | -2275 |
| Rabggta | -4972 | -3450 |
| Rabggtb | -3434 | -1391 |
| Trp53 | 4978 | 4881 |
| Trp53bp2 | 2617 | 1007 |
| Trp63 | 2314 | 3879 |
Intrinsic-Pathway-for-Apoptosis
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 0.575 |
| p.adjustMANOVA | 0.65 |
| s.dist | 0.0485 |
| s.young | 0.0483 |
| s.old | -0.00457 |
| p.young | 0.567 |
| p.old | 0.957 |
| Gene | young | old |
|---|---|---|
| Casp9 | 3738 | -2865 |
| Ppp3r1 | 1460 | -6334 |
| Casp7 | 1119 | -3675 |
| Ywhab | 1382 | -1493 |
| Mapk3 | 1686 | -900 |
| Bmf | 1641 | -920 |
| Ppp3cc | 483 | -771 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Akt1 | -6210 | -5765 |
| Akt2 | -7113 | -6780 |
| Akt3 | 2614 | 4706 |
| Apaf1 | 5176 | 5355 |
| Apip | -6666 | -7349 |
| Aven | 617 | 5295 |
| Bad | 4020 | 3510 |
| Bak1 | 4444 | 3458 |
| Bax | 5258 | 3874 |
| Bcl2 | 7330 | 6782 |
| Bcl2l1 | -4607 | -544 |
| Bcl2l11 | -4296 | -6286 |
| Bid | 4293 | 4165 |
| Bmf | 1641 | -920 |
| C1qbp | -6500 | -7227 |
| Casp3 | 6837 | 4230 |
| Casp7 | 1119 | -3675 |
| Casp8 | -791 | -3340 |
| Casp9 | 3738 | -2865 |
| Cycs | -7133 | -7302 |
| Diablo | -7319 | -7593 |
| Dynll1 | 5075 | 5782 |
| Dynll2 | -6128 | -5510 |
| E2f1 | 4237 | 5630 |
| Mapk1 | -4365 | -6214 |
| Mapk3 | 1686 | -900 |
| Mapk8 | -2142 | -2173 |
| Nmt1 | 934 | 594 |
| Pmaip1 | 3797 | 1356 |
| Ppp1r13b | -4238 | -2275 |
| Ppp3cc | 483 | -771 |
| Ppp3r1 | 1460 | -6334 |
| Sfn | 2885 | 2824 |
| Stat3 | 4087 | 345 |
| Tfdp1 | 4017 | 1507 |
| Tfdp2 | -4634 | -7148 |
| Trp53 | 4978 | 4881 |
| Trp53bp2 | 2617 | 1007 |
| Trp63 | 2314 | 3879 |
| Uaca | 1091 | 5187 |
| Xiap | -716 | -3113 |
| Ywhab | 1382 | -1493 |
| Ywhae | -5312 | -6195 |
| Ywhag | -2287 | -1315 |
| Ywhah | 5584 | 3890 |
| Ywhaq | 2145 | 2532 |
| Ywhaz | 5524 | 2659 |
Regulation-of-gene-expression-by-Hypoxia-inducible-Factor
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.799 |
| p.adjustMANOVA | 0.863 |
| s.dist | 0.087 |
| s.young | -0.0173 |
| s.old | -0.0852 |
| p.young | 0.924 |
| p.old | 0.641 |
| Gene | young | old |
|---|---|---|
| Vegfa | -6273 | -7378 |
| Higd1a | -5965 | -7009 |
| Epas1 | -5094 | -7186 |
| Crebbp | -3332 | -3533 |
| Hif3a | -2849 | -3750 |
| Ep300 | -2809 | -454 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Arnt | 5880 | 5777 |
| Car9 | 6540 | 6683 |
| Cited2 | 6879 | 5555 |
| Crebbp | -3332 | -3533 |
| Ep300 | -2809 | -454 |
| Epas1 | -5094 | -7186 |
| Hif1a | 6604 | 1121 |
| Hif3a | -2849 | -3750 |
| Higd1a | -5965 | -7009 |
| Vegfa | -6273 | -7378 |
Apoptosis
| metric | value |
|---|---|
| setSize | 152 |
| pMANOVA | 0.829 |
| p.adjustMANOVA | 0.863 |
| s.dist | 0.0142 |
| s.young | -0.0137 |
| s.old | 0.00372 |
| p.young | 0.77 |
| p.old | 0.937 |
| Gene | young | old |
|---|---|---|
| Psmd7 | -3344 | 2462 |
| Sptan1 | -525 | 5294 |
| Psmd4 | -73 | 2814 |
| Psmc6 | -3319 | 55 |
| Traf2 | -9 | 1142 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acin1 | -2564 | -1364 |
| Add1 | 4420 | 1516 |
| Akt1 | -6210 | -5765 |
| Akt2 | -7113 | -6780 |
| Akt3 | 2614 | 4706 |
| Apaf1 | 5176 | 5355 |
| Apc | 6673 | 5921 |
| Apip | -6666 | -7349 |
| Appl1 | 4730 | 2680 |
| Arhgap10 | -5360 | -3726 |
| Aven | 617 | 5295 |
| Bad | 4020 | 3510 |
| Bak1 | 4444 | 3458 |
| Bax | 5258 | 3874 |
| Bcap31 | 410 | 567 |
| Bcl2 | 7330 | 6782 |
| Bcl2l1 | -4607 | -544 |
| Bcl2l11 | -4296 | -6286 |
| Bid | 4293 | 4165 |
| Birc2 | -3354 | -4484 |
| Bmf | 1641 | -920 |
| Bmx | 5463 | 1734 |
| C1qbp | -6500 | -7227 |
| Casp3 | 6837 | 4230 |
| Casp6 | 3830 | -3643 |
| Casp7 | 1119 | -3675 |
| Casp8 | -791 | -3340 |
| Casp9 | 3738 | -2865 |
| Cd14 | 4163 | 3474 |
| Cflar | -4133 | -2358 |
| Clspn | 5575 | 4859 |
| Ctnnb1 | -2555 | -3976 |
| Cycs | -7133 | -7302 |
| Dapk1 | -5742 | -5874 |
| Dapk2 | 230 | 4481 |
| Dapk3 | 4951 | 2626 |
| Dbnl | 6620 | 4826 |
| Dffa | -4838 | -5860 |
| Dffb | -2373 | -68 |
| Diablo | -7319 | -7593 |
| Dnm1l | -4000 | -6171 |
| Dsg2 | 1165 | -443 |
| Dsp | 4886 | -1017 |
| Dynll1 | 5075 | 5782 |
| Dynll2 | -6128 | -5510 |
| E2f1 | 4237 | 5630 |
| Fadd | 3556 | -919 |
| Fas | -4946 | -4767 |
| Fnta | -2838 | -2939 |
| Gas2 | 5281 | 6069 |
| Gm11808 | -5706 | -216 |
| Gsn | 4065 | 5762 |
| Hmgb2 | 3249 | -1172 |
| Kpna1 | -269 | -3809 |
| Kpnb1 | -2201 | -4623 |
| Lmna | 7232 | 6208 |
| Lmnb1 | 3372 | -1783 |
| Ly96 | 2458 | 2873 |
| Maged1 | 6689 | 4367 |
| Mapk1 | -4365 | -6214 |
| Mapk3 | 1686 | -900 |
| Mapk8 | -2142 | -2173 |
| Mapt | -4280 | -1351 |
| Nmt1 | 934 | 594 |
| Ocln | 216 | -2246 |
| Oma1 | -6335 | -7529 |
| Opa1 | -6928 | -7669 |
| Pak2 | 1636 | -1595 |
| Plec | 1669 | 2349 |
| Pmaip1 | 3797 | 1356 |
| Ppp1r13b | -4238 | -2275 |
| Ppp3cc | 483 | -771 |
| Ppp3r1 | 1460 | -6334 |
| Prkcd | 5903 | 6193 |
| Prkcq | -3932 | -3811 |
| Psma1 | -5057 | -5354 |
| Psma3 | -1668 | -1270 |
| Psma4 | -4195 | -5256 |
| Psma5 | 917 | 4879 |
| Psma6 | -6198 | -4392 |
| Psma7 | -5203 | -1132 |
| Psmb1 | -3490 | -1504 |
| Psmb10 | 3247 | 6154 |
| Psmb2 | -6229 | -6389 |
| Psmb3 | -6394 | -4507 |
| Psmb4 | -4157 | -2719 |
| Psmb5 | -5358 | -2463 |
| Psmb6 | -5905 | -4631 |
| Psmb7 | -6295 | -6022 |
| Psmb8 | 188 | 2895 |
| Psmb9 | 239 | 987 |
| Psmc1 | -4509 | -1482 |
| Psmc2 | -5438 | -4371 |
| Psmc3 | -5727 | -3198 |
| Psmc4 | 580 | 1965 |
| Psmc5 | -5068 | -3092 |
| Psmc6 | -3319 | 55 |
| Psmd1 | -4493 | -2930 |
| Psmd10 | 2830 | -1174 |
| Psmd11 | 5474 | 5901 |
| Psmd12 | -5949 | -6045 |
| Psmd13 | 2269 | 4514 |
| Psmd14 | 1389 | 1667 |
| Psmd2 | -4258 | -2549 |
| Psmd3 | -5414 | -2387 |
| Psmd4 | -73 | 2814 |
| Psmd5 | 2751 | 2805 |
| Psmd6 | -2219 | -3583 |
| Psmd7 | -3344 | 2462 |
| Psmd8 | 5830 | 6151 |
| Psmd9 | 811 | -3604 |
| Psme1 | -7082 | -7176 |
| Psme2b | -2823 | -3837 |
| Psme3 | -4430 | -5111 |
| Psme4 | -5860 | -5252 |
| Psmf1 | 1562 | 263 |
| Ptk2 | 1246 | -212 |
| Ripk1 | 3817 | 949 |
| Rock1 | 1759 | 4127 |
| Rps27a | -1504 | -1029 |
| Satb1 | 6347 | 5016 |
| Sfn | 2885 | 2824 |
| Sptan1 | -525 | 5294 |
| Stat3 | 4087 | 345 |
| Stk24 | -3201 | -6950 |
| Stk26 | 3724 | 3841 |
| Tfdp1 | 4017 | 1507 |
| Tfdp2 | -4634 | -7148 |
| Ticam1 | 4313 | 1929 |
| Tjp1 | -3710 | -5609 |
| Tjp2 | 6209 | 6194 |
| Tlr4 | 6952 | 6766 |
| Tnfrsf26 | 1739 | 3486 |
| Tnfsf10 | -4361 | -3659 |
| Tradd | 5674 | 5445 |
| Traf2 | -9 | 1142 |
| Trp53 | 4978 | 4881 |
| Trp53bp2 | 2617 | 1007 |
| Trp63 | 2314 | 3879 |
| Uaca | 1091 | 5187 |
| Ubb | 5763 | -1908 |
| Ubc | -1436 | -1699 |
| Unc5a | 6273 | 4626 |
| Unc5b | 6704 | 6481 |
| Vim | 7124 | 6031 |
| Xiap | -716 | -3113 |
| Ywhab | 1382 | -1493 |
| Ywhae | -5312 | -6195 |
| Ywhag | -2287 | -1315 |
| Ywhah | 5584 | 3890 |
| Ywhaq | 2145 | 2532 |
| Ywhaz | 5524 | 2659 |
Fatty-acyl-CoA-biosynthesis
| metric | value |
|---|---|
| setSize | 28 |
| pMANOVA | 0.878 |
| p.adjustMANOVA | 0.878 |
| s.dist | 0.0712 |
| s.young | -0.0445 |
| s.old | -0.0556 |
| p.young | 0.684 |
| p.old | 0.611 |
| Gene | young | old |
|---|---|---|
| Acsl6 | -7255 | -7818 |
| Acsl1 | -6926 | -7461 |
| Acsf3 | -6626 | -7575 |
| Cbr4 | -6830 | -7226 |
| Tecr | -7151 | -6741 |
| Scd4 | -6898 | -6839 |
| H2-Ke6 | -6180 | -5754 |
| Ppt2 | -5289 | -5808 |
| Elovl5 | -3997 | -5603 |
| Acly | -3791 | -3425 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Acaca | 3453 | -653 |
| Acly | -3791 | -3425 |
| Acsf3 | -6626 | -7575 |
| Acsl1 | -6926 | -7461 |
| Acsl3 | 2818 | -794 |
| Acsl4 | 4513 | 954 |
| Acsl5 | 3226 | 5103 |
| Acsl6 | -7255 | -7818 |
| Cbr4 | -6830 | -7226 |
| Elovl1 | 5112 | 5663 |
| Elovl5 | -3997 | -5603 |
| Elovl6 | 3634 | 2877 |
| Elovl7 | 4758 | -245 |
| Fasn | 4789 | 4808 |
| H2-Ke6 | -6180 | -5754 |
| Hacd1 | -4729 | 1304 |
| Hacd2 | 4010 | -3297 |
| Hacd3 | 3435 | 5413 |
| Hacd4 | 5683 | 4021 |
| Hsd17b12 | 1383 | 3088 |
| Morc2b | 1565 | 2940 |
| Ppt1 | 800 | -4376 |
| Ppt2 | -5289 | -5808 |
| Scd4 | -6898 | -6839 |
| Slc25a1 | 6669 | 5317 |
| Slc27a3 | 4118 | 4704 |
| Tecr | -7151 | -6741 |
| Tecrl | -1100 | 5110 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0 beeswarm_0.2.3 gtools_3.8.2
## [5] echarts4r_0.3.2 mitch_1.0.6 gplots_3.0.3 reshape2_1.4.4
## [9] forcats_0.5.0 stringr_1.4.0 dplyr_1.0.0 purrr_0.3.4
## [13] readr_1.3.1 tidyr_1.1.0 tibble_3.0.1 ggplot2_3.3.2
## [17] tidyverse_1.3.0
##
## loaded via a namespace (and not attached):
## [1] nlme_3.1-148 bitops_1.0-6 fs_1.4.2 lubridate_1.7.9
## [5] RColorBrewer_1.1-2 httr_1.4.1 rprojroot_1.3-2 tools_4.0.2
## [9] backports_1.1.8 R6_2.4.1 KernSmooth_2.23-17 DBI_1.1.0
## [13] colorspace_1.4-1 withr_2.2.0 tidyselect_1.1.0 gridExtra_2.3
## [17] compiler_4.0.2 cli_2.0.2 rvest_0.3.5 xml2_1.3.2
## [21] desc_1.2.0 labeling_0.3 caTools_1.18.0 scales_1.1.1
## [25] digest_0.6.25 rmarkdown_2.3 pkgconfig_2.0.3 htmltools_0.5.0
## [29] dbplyr_1.4.4 fastmap_1.0.1 highr_0.8 htmlwidgets_1.5.1
## [33] rlang_0.4.6 readxl_1.3.1 rstudioapi_0.11 shiny_1.5.0
## [37] generics_0.0.2 farver_2.0.3 jsonlite_1.7.0 magrittr_1.5
## [41] Rcpp_1.0.4.6 munsell_0.5.0 fansi_0.4.1 lifecycle_0.2.0
## [45] stringi_1.4.6 yaml_2.2.1 MASS_7.3-51.6 plyr_1.8.6
## [49] grid_4.0.2 blob_1.2.1 parallel_4.0.2 gdata_2.18.0
## [53] promises_1.1.1 crayon_1.3.4 lattice_0.20-41 haven_2.3.1
## [57] hms_0.5.3 knitr_1.29 pillar_1.4.4 reprex_0.3.0
## [61] glue_1.4.1 evaluate_0.14 modelr_0.1.8 vctrs_0.3.1
## [65] httpuv_1.5.4 testthat_2.3.2 cellranger_1.1.0 gtable_0.3.0
## [69] reshape_0.8.8 assertthat_0.2.1 xfun_0.15 mime_0.9
## [73] xtable_1.8-4 broom_0.5.6 later_1.1.0.1 pbmcapply_1.5.0
## [77] ellipsis_0.3.1END of report