Mitch Report

date generated: 2020-07-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    young        old
## 0610009B22Rik -2.9385024 -6.1805927
## 0610009E02Rik  0.6410018 -1.6821055
## 0610009L18Rik -4.5856767 -3.1288917
## 0610010F05Rik  0.6483013  0.4402823
## 0610010K14Rik -8.7879236 -3.0864256
## 0610012G03Rik -8.7415080 -6.4223694

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	14877
duplicated_genes_present	0
num_profile_genes_in_sets	7299
num_profile_genes_not_in_sets	7578
profile_pearson_correl	0.8374
profile_spearman_correl	0.80977

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ../ref/ReactomePathways_mouse.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2302
num_genesets_excluded	1023
num_genesets_included	1279

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 245

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.young	s.old	p.young	p.old
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport	167	1.25e-82	1.60e-79	1.1700	-0.8350	-0.8130	5.14e-78	5.46e-74
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	120	4.61e-65	2.95e-62	1.2200	-0.8830	-0.8360	5.28e-63	1.12e-56
Respiratory-electron-transport	100	4.63e-57	1.97e-54	1.2500	-0.9040	-0.8590	2.80e-55	4.76e-50
Metabolism	1613	5.51e-49	1.76e-46	0.3000	-0.2000	-0.2240	1.76e-39	2.43e-49
Mitochondrial-translation	94	6.95e-44	1.78e-41	1.1200	-0.8250	-0.7580	1.11e-43	4.24e-37
Mitochondrial-translation-elongation	88	2.90e-41	6.18e-39	1.1200	-0.8270	-0.7580	3.38e-41	8.11e-35
Mitochondrial-translation-termination	88	4.51e-41	8.23e-39	1.1200	-0.8250	-0.7560	5.15e-41	1.18e-34
Mitochondrial-translation-initiation	88	1.35e-40	2.16e-38	1.1100	-0.8210	-0.7500	1.25e-40	4.30e-34
Extracellular-matrix-organization	228	1.35e-38	1.92e-36	0.6770	0.4990	0.4580	1.41e-38	1.08e-32
Complex-I-biogenesis	54	1.62e-33	2.07e-31	1.3000	-0.9300	-0.9040	2.28e-32	1.25e-30
Translation	241	4.00e-31	4.66e-29	0.5950	-0.4150	-0.4260	1.35e-28	4.55e-30
Protein-localization	142	7.41e-29	7.90e-27	0.7420	-0.5120	-0.5370	6.06e-26	2.04e-28
Mitochondrial-protein-import	57	8.67e-23	8.53e-21	1.0300	-0.7620	-0.6860	2.29e-23	2.95e-19
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle	51	4.48e-21	4.10e-19	1.0500	-0.7250	-0.7600	3.15e-19	5.37e-21
Mitochondrial-biogenesis	88	1.70e-19	1.45e-17	0.7690	-0.5300	-0.5570	7.78e-18	1.67e-19
Collagen-biosynthesis-and-modifying-enzymes	56	1.44e-17	1.15e-15	0.9140	0.6370	0.6550	1.59e-16	2.10e-17
Cristae-formation	29	4.27e-17	3.22e-15	1.2500	-0.9050	-0.8610	3.21e-17	9.79e-16
Mitochondrial-Fatty-Acid-Beta-Oxidation	31	5.13e-17	3.65e-15	1.2100	-0.8580	-0.8500	1.25e-16	2.49e-16
Collagen-formation	75	1.22e-16	8.24e-15	0.7690	0.5460	0.5420	3.06e-16	4.96e-16
Collagen-chain-trimerization	33	1.12e-13	7.15e-12	1.0400	0.7370	0.7400	2.34e-13	1.79e-13
Citric-acid-cycle-(TCA-cycle)	22	2.51e-13	1.53e-11	1.2600	-0.8940	-0.8890	3.71e-13	5.02e-13
Signal-Transduction	1697	3.11e-13	1.81e-11	0.1440	0.1130	0.0899	3.26e-14	1.55e-09
ECM-proteoglycans	43	3.42e-13	1.90e-11	0.8860	0.6610	0.5900	6.20e-14	2.23e-11
Glycosaminoglycan-metabolism	99	1.18e-12	6.29e-11	0.5510	0.4310	0.3430	1.26e-13	3.57e-09
Peroxisomal-protein-import	53	2.97e-12	1.52e-10	0.7290	-0.4460	-0.5770	1.95e-08	3.55e-13
Metabolism-of-amino-acids-and-derivatives	256	1.02e-11	5.03e-10	0.3470	-0.2410	-0.2510	3.75e-11	5.47e-12
rRNA-processing-in-the-mitochondrion	22	1.56e-11	7.41e-10	1.1600	-0.7830	-0.8540	2.00e-10	3.93e-12
Fatty-acid-metabolism	131	2.54e-11	1.16e-09	0.4600	-0.2940	-0.3530	6.46e-09	2.95e-12
Degradation-of-the-extracellular-matrix	74	5.69e-11	2.49e-09	0.5310	0.4450	0.2890	3.56e-11	1.80e-05
Branched-chain-amino-acid-catabolism	19	5.85e-11	2.49e-09	1.2200	-0.8590	-0.8710	9.04e-11	4.89e-11
Glyoxylate-metabolism-and-glycine-degradation	25	7.78e-11	3.12e-09	1.0600	-0.7510	-0.7480	7.74e-11	9.53e-11
Elastic-fibre-formation	38	7.80e-11	3.12e-09	0.8600	0.6080	0.6080	8.52e-11	8.68e-11
Assembly-of-collagen-fibrils-and-other-multimeric-structures	46	8.17e-11	3.17e-09	0.7690	0.5760	0.5090	1.34e-11	2.38e-09
Metabolism-of-lipids	575	1.26e-10	4.72e-09	0.1910	-0.1040	-0.1600	2.19e-05	7.10e-11
Formation-of-ATP-by-chemiosmotic-coupling	16	1.29e-10	4.72e-09	1.3100	-0.9330	-0.9190	1.02e-10	1.89e-10
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic	168	7.64e-10	2.71e-08	0.2450	0.2300	0.0831	2.68e-07	6.36e-02
tRNA-processing-in-the-mitochondrion	18	3.43e-09	1.18e-07	1.1300	-0.7500	-0.8420	3.52e-08	6.26e-10
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)	84	4.05e-09	1.36e-07	0.5210	0.3890	0.3470	7.59e-10	3.74e-08
Asparagine-N-linked-glycosylation	251	7.80e-09	2.56e-07	0.1140	0.1110	-0.0245	2.51e-03	5.05e-01
Chondroitin-sulfate/dermatan-sulfate-metabolism	42	1.03e-08	3.30e-07	0.7070	0.5400	0.4560	1.42e-09	3.11e-07
Interferon-alpha/beta-signaling	40	1.39e-08	4.33e-07	0.3630	0.0479	0.3600	6.01e-01	8.18e-05
Membrane-Trafficking	530	1.50e-08	4.57e-07	0.1050	0.1030	0.0175	5.05e-05	4.93e-01
Post-translational-protein-phosphorylation	77	2.65e-08	7.88e-07	0.5180	0.3850	0.3480	5.49e-09	1.34e-07
Mitochondrial-tRNA-aminoacylation	19	3.66e-08	1.06e-06	1.0400	-0.7560	-0.7120	1.14e-08	7.59e-08
Transcriptional-activation-of-mitochondrial-biogenesis	51	3.86e-08	1.10e-06	0.6280	-0.4180	-0.4680	2.43e-07	7.23e-09
tRNA-Aminoacylation	26	4.87e-08	1.35e-06	0.8700	-0.6520	-0.5760	8.49e-09	3.70e-07
Pyruvate-metabolism	27	5.41e-08	1.47e-06	0.8530	-0.5670	-0.6370	3.40e-07	9.95e-09
Vesicle-mediated-transport	560	1.04e-07	2.77e-06	0.1020	0.0998	0.0224	5.99e-05	3.68e-01
Metabolism-of-proteins	1577	1.20e-07	3.14e-06	0.0624	-0.0131	-0.0610	3.93e-01	7.33e-05
Integrin-cell-surface-interactions	53	1.23e-07	3.14e-06	0.6020	0.4300	0.4210	5.95e-08	1.12e-07

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.young	s.old	p.young	p.old
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport	167	1.25e-82	1.60e-79	1.17000	-0.835000	-8.13e-01	5.14e-78	5.46e-74
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	120	4.61e-65	2.95e-62	1.22000	-0.883000	-8.36e-01	5.28e-63	1.12e-56
Respiratory-electron-transport	100	4.63e-57	1.97e-54	1.25000	-0.904000	-8.59e-01	2.80e-55	4.76e-50
Metabolism	1613	5.51e-49	1.76e-46	0.30000	-0.200000	-2.24e-01	1.76e-39	2.43e-49
Mitochondrial-translation	94	6.95e-44	1.78e-41	1.12000	-0.825000	-7.58e-01	1.11e-43	4.24e-37
Mitochondrial-translation-elongation	88	2.90e-41	6.18e-39	1.12000	-0.827000	-7.58e-01	3.38e-41	8.11e-35
Mitochondrial-translation-termination	88	4.51e-41	8.23e-39	1.12000	-0.825000	-7.56e-01	5.15e-41	1.18e-34
Mitochondrial-translation-initiation	88	1.35e-40	2.16e-38	1.11000	-0.821000	-7.50e-01	1.25e-40	4.30e-34
Extracellular-matrix-organization	228	1.35e-38	1.92e-36	0.67700	0.499000	4.58e-01	1.41e-38	1.08e-32
Complex-I-biogenesis	54	1.62e-33	2.07e-31	1.30000	-0.930000	-9.04e-01	2.28e-32	1.25e-30
Translation	241	4.00e-31	4.66e-29	0.59500	-0.415000	-4.26e-01	1.35e-28	4.55e-30
Protein-localization	142	7.41e-29	7.90e-27	0.74200	-0.512000	-5.37e-01	6.06e-26	2.04e-28
Mitochondrial-protein-import	57	8.67e-23	8.53e-21	1.03000	-0.762000	-6.86e-01	2.29e-23	2.95e-19
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle	51	4.48e-21	4.10e-19	1.05000	-0.725000	-7.60e-01	3.15e-19	5.37e-21
Mitochondrial-biogenesis	88	1.70e-19	1.45e-17	0.76900	-0.530000	-5.57e-01	7.78e-18	1.67e-19
Collagen-biosynthesis-and-modifying-enzymes	56	1.44e-17	1.15e-15	0.91400	0.637000	6.55e-01	1.59e-16	2.10e-17
Cristae-formation	29	4.27e-17	3.22e-15	1.25000	-0.905000	-8.61e-01	3.21e-17	9.79e-16
Mitochondrial-Fatty-Acid-Beta-Oxidation	31	5.13e-17	3.65e-15	1.21000	-0.858000	-8.50e-01	1.25e-16	2.49e-16
Collagen-formation	75	1.22e-16	8.24e-15	0.76900	0.546000	5.42e-01	3.06e-16	4.96e-16
Collagen-chain-trimerization	33	1.12e-13	7.15e-12	1.04000	0.737000	7.40e-01	2.34e-13	1.79e-13
Citric-acid-cycle-(TCA-cycle)	22	2.51e-13	1.53e-11	1.26000	-0.894000	-8.89e-01	3.71e-13	5.02e-13
Signal-Transduction	1697	3.11e-13	1.81e-11	0.14400	0.113000	8.99e-02	3.26e-14	1.55e-09
ECM-proteoglycans	43	3.42e-13	1.90e-11	0.88600	0.661000	5.90e-01	6.20e-14	2.23e-11
Glycosaminoglycan-metabolism	99	1.18e-12	6.29e-11	0.55100	0.431000	3.43e-01	1.26e-13	3.57e-09
Peroxisomal-protein-import	53	2.97e-12	1.52e-10	0.72900	-0.446000	-5.77e-01	1.95e-08	3.55e-13
Metabolism-of-amino-acids-and-derivatives	256	1.02e-11	5.03e-10	0.34700	-0.241000	-2.51e-01	3.75e-11	5.47e-12
rRNA-processing-in-the-mitochondrion	22	1.56e-11	7.41e-10	1.16000	-0.783000	-8.54e-01	2.00e-10	3.93e-12
Fatty-acid-metabolism	131	2.54e-11	1.16e-09	0.46000	-0.294000	-3.53e-01	6.46e-09	2.95e-12
Degradation-of-the-extracellular-matrix	74	5.69e-11	2.49e-09	0.53100	0.445000	2.89e-01	3.56e-11	1.80e-05
Branched-chain-amino-acid-catabolism	19	5.85e-11	2.49e-09	1.22000	-0.859000	-8.71e-01	9.04e-11	4.89e-11
Glyoxylate-metabolism-and-glycine-degradation	25	7.78e-11	3.12e-09	1.06000	-0.751000	-7.48e-01	7.74e-11	9.53e-11
Elastic-fibre-formation	38	7.80e-11	3.12e-09	0.86000	0.608000	6.08e-01	8.52e-11	8.68e-11
Assembly-of-collagen-fibrils-and-other-multimeric-structures	46	8.17e-11	3.17e-09	0.76900	0.576000	5.09e-01	1.34e-11	2.38e-09
Metabolism-of-lipids	575	1.26e-10	4.72e-09	0.19100	-0.104000	-1.60e-01	2.19e-05	7.10e-11
Formation-of-ATP-by-chemiosmotic-coupling	16	1.29e-10	4.72e-09	1.31000	-0.933000	-9.19e-01	1.02e-10	1.89e-10
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic	168	7.64e-10	2.71e-08	0.24500	0.230000	8.31e-02	2.68e-07	6.36e-02
tRNA-processing-in-the-mitochondrion	18	3.43e-09	1.18e-07	1.13000	-0.750000	-8.42e-01	3.52e-08	6.26e-10
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)	84	4.05e-09	1.36e-07	0.52100	0.389000	3.47e-01	7.59e-10	3.74e-08
Asparagine-N-linked-glycosylation	251	7.80e-09	2.56e-07	0.11400	0.111000	-2.45e-02	2.51e-03	5.05e-01
Chondroitin-sulfate/dermatan-sulfate-metabolism	42	1.03e-08	3.30e-07	0.70700	0.540000	4.56e-01	1.42e-09	3.11e-07
Interferon-alpha/beta-signaling	40	1.39e-08	4.33e-07	0.36300	0.047900	3.60e-01	6.01e-01	8.18e-05
Membrane-Trafficking	530	1.50e-08	4.57e-07	0.10500	0.103000	1.75e-02	5.05e-05	4.93e-01
Post-translational-protein-phosphorylation	77	2.65e-08	7.88e-07	0.51800	0.385000	3.48e-01	5.49e-09	1.34e-07
Mitochondrial-tRNA-aminoacylation	19	3.66e-08	1.06e-06	1.04000	-0.756000	-7.12e-01	1.14e-08	7.59e-08
Transcriptional-activation-of-mitochondrial-biogenesis	51	3.86e-08	1.10e-06	0.62800	-0.418000	-4.68e-01	2.43e-07	7.23e-09
tRNA-Aminoacylation	26	4.87e-08	1.35e-06	0.87000	-0.652000	-5.76e-01	8.49e-09	3.70e-07
Pyruvate-metabolism	27	5.41e-08	1.47e-06	0.85300	-0.567000	-6.37e-01	3.40e-07	9.95e-09
Vesicle-mediated-transport	560	1.04e-07	2.77e-06	0.10200	0.099800	2.24e-02	5.99e-05	3.68e-01
Metabolism-of-proteins	1577	1.20e-07	3.14e-06	0.06240	-0.013100	-6.10e-02	3.93e-01	7.33e-05
Integrin-cell-surface-interactions	53	1.23e-07	3.14e-06	0.60200	0.430000	4.21e-01	5.95e-08	1.12e-07
Metabolism-of-RNA	619	1.46e-07	3.67e-06	0.17800	-0.129000	-1.23e-01	4.75e-08	2.26e-07
TP53-Regulates-Metabolic-Genes	85	1.59e-07	3.92e-06	0.47200	-0.335000	-3.33e-01	9.34e-08	1.13e-07
Heparan-sulfate/heparin-(HS-GAG)-metabolism	42	1.75e-07	4.23e-06	0.55100	0.471000	2.87e-01	1.31e-07	1.31e-03
Immune-System	1477	5.03e-07	1.19e-05	0.11200	0.085000	7.26e-02	7.86e-08	4.51e-06
Metabolism-of-cofactors	18	6.03e-07	1.40e-05	0.97900	-0.703000	-6.81e-01	2.41e-07	5.56e-07
O-linked-glycosylation	74	6.33e-07	1.45e-05	0.41200	0.346000	2.24e-01	2.66e-07	8.88e-04
Post-translational-protein-modification	1122	8.61e-07	1.93e-05	0.06270	0.062100	8.38e-03	5.27e-04	6.40e-01
COPI-dependent-Golgi-to-ER-retrograde-traffic	74	1.18e-06	2.61e-05	0.36200	0.319000	1.71e-01	2.15e-06	1.09e-02
Signaling-by-Rho-GTPases	340	1.22e-06	2.65e-05	0.21900	0.146000	1.64e-01	3.89e-06	2.40e-07
Diseases-of-glycosylation	113	1.33e-06	2.82e-05	0.33900	0.278000	1.93e-01	3.33e-07	3.94e-04
Signaling-by-Receptor-Tyrosine-Kinases	390	1.34e-06	2.82e-05	0.17900	0.149000	9.92e-02	4.50e-07	8.10e-04
Molecules-associated-with-elastic-fibres	28	1.45e-06	2.98e-05	0.75800	0.516000	5.54e-01	2.25e-06	3.82e-07
Golgi-to-ER-retrograde-transport	105	1.65e-06	3.35e-05	0.30200	0.266000	1.44e-01	2.62e-06	1.07e-02
Non-integrin-membrane-ECM-interactions	41	1.74e-06	3.49e-05	0.61500	0.461000	4.06e-01	3.18e-07	6.74e-06
Hemostasis	440	2.40e-06	4.72e-05	0.18700	0.142000	1.21e-01	3.95e-07	1.39e-05
Transport-to-the-Golgi-and-subsequent-modification	145	2.99e-06	5.79e-05	0.11600	0.110000	-3.79e-02	2.23e-02	4.32e-01
Diseases-associated-with-glycosaminoglycan-metabolism	34	7.91e-06	1.51e-04	0.62800	0.479000	4.06e-01	1.31e-06	4.26e-05
Triglyceride-catabolism	15	9.29e-06	1.75e-04	0.86800	-0.503000	-7.08e-01	7.41e-04	2.07e-06
Processing-of-Capped-Intron-Containing-Pre-mRNA	230	1.11e-05	2.06e-04	0.24600	-0.172000	-1.77e-01	7.62e-06	4.18e-06
O-linked-glycosylation-of-mucins	32	1.25e-05	2.29e-04	0.41100	0.386000	1.41e-01	1.55e-04	1.69e-01
Regulation-of-Apoptosis	49	1.45e-05	2.61e-04	0.39000	-0.347000	-1.77e-01	2.60e-05	3.17e-02
ABC-family-proteins-mediated-transport	89	1.75e-05	3.10e-04	0.33400	-0.279000	-1.85e-01	5.62e-06	2.63e-03
mRNA-Splicing---Major-Pathway	172	1.87e-05	3.27e-04	0.27700	-0.191000	-2.01e-01	1.53e-05	5.88e-06
Glycerophospholipid-biosynthesis	102	1.98e-05	3.42e-04	0.35900	-0.253000	-2.55e-01	1.02e-05	8.93e-06
DNA-Replication-Pre-Initiation	80	2.28e-05	3.89e-04	0.14600	-0.139000	4.26e-02	3.15e-02	5.10e-01
mRNA-Splicing	180	2.48e-05	4.17e-04	0.26800	-0.190000	-1.89e-01	1.16e-05	1.20e-05
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex	15	2.55e-05	4.24e-04	0.91400	-0.615000	-6.76e-01	3.77e-05	5.76e-06
RHO-GTPase-Effectors	220	2.69e-05	4.30e-04	0.24100	0.165000	1.75e-01	2.50e-05	7.61e-06
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A	48	2.72e-05	4.30e-04	0.33900	-0.315000	-1.27e-01	1.64e-04	1.29e-01
p53-Independent-DNA-Damage-Response	48	2.72e-05	4.30e-04	0.33900	-0.315000	-1.27e-01	1.64e-04	1.29e-01
p53-Independent-G1/S-DNA-damage-checkpoint	48	2.72e-05	4.30e-04	0.33900	-0.315000	-1.27e-01	1.64e-04	1.29e-01
CDT1-association-with-the-CDC6:ORC:origin-complex	55	2.89e-05	4.51e-04	0.32000	-0.296000	-1.23e-01	1.49e-04	1.16e-01
Peroxisomal-lipid-metabolism	22	3.71e-05	5.65e-04	0.68700	-0.409000	-5.52e-01	9.02e-04	7.27e-06
Vif-mediated-degradation-of-APOBEC3G	48	3.71e-05	5.65e-04	0.37600	-0.335000	-1.70e-01	5.91e-05	4.14e-02
Regulation-of-ornithine-decarboxylase-(ODC)	46	3.97e-05	5.96e-04	0.34700	-0.320000	-1.35e-01	1.73e-04	1.13e-01
MET-promotes-cell-motility	27	4.01e-05	5.96e-04	0.58800	0.488000	3.29e-01	1.16e-05	3.08e-03
Chondroitin-sulfate-biosynthesis	16	4.32e-05	6.35e-04	0.87000	0.625000	6.05e-01	1.52e-05	2.75e-05
Cilium-Assembly	176	4.78e-05	6.95e-04	0.24700	0.195000	1.52e-01	8.38e-06	5.08e-04
Laminin-interactions	22	5.04e-05	7.24e-04	0.69800	0.548000	4.33e-01	8.72e-06	4.33e-04
Vpu-mediated-degradation-of-CD4	48	5.10e-05	7.25e-04	0.35800	-0.323000	-1.54e-01	1.09e-04	6.44e-02
Interleukin-4-and-Interleukin-13-signaling	76	5.17e-05	7.26e-04	0.31000	0.271000	1.51e-01	4.48e-05	2.30e-02
Triglyceride-metabolism	22	6.65e-05	9.17e-04	0.68400	-0.420000	-5.39e-01	6.50e-04	1.19e-05
Assembly-of-the-pre-replicative-complex	64	6.67e-05	9.17e-04	0.18600	-0.186000	-3.35e-04	9.99e-03	9.96e-01
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation	46	6.86e-05	9.33e-04	0.34300	-0.315000	-1.37e-01	2.24e-04	1.08e-01
Mitochondrial-iron-sulfur-cluster-biogenesis	10	6.99e-05	9.35e-04	1.07000	-0.741000	-7.75e-01	4.95e-05	2.19e-05
Syndecan-interactions	20	7.01e-05	9.35e-04	0.75900	0.544000	5.29e-01	2.50e-05	4.16e-05
Autodegradation-of-the-E3-ubiquitin-ligase-COP1	47	7.41e-05	9.77e-04	0.31500	-0.295000	-1.10e-01	4.69e-04	1.92e-01
Stabilization-of-p53	51	7.50e-05	9.79e-04	0.29100	-0.276000	-9.40e-02	6.62e-04	2.46e-01
ABC-transporter-disorders	66	7.84e-05	1.01e-03	0.32200	-0.283000	-1.55e-01	7.23e-05	2.99e-02
SCF-beta-TrCP-mediated-degradation-of-Emi1	51	8.26e-05	1.06e-03	0.33500	-0.303000	-1.42e-01	1.81e-04	8.02e-02
Platelet-degranulation	108	9.24e-05	1.17e-03	0.29600	0.238000	1.75e-01	1.91e-05	1.69e-03
Gluconeogenesis	26	9.45e-05	1.18e-03	0.64000	-0.417000	-4.86e-01	2.36e-04	1.78e-05
Orc1-removal-from-chromatin	66	9.92e-05	1.22e-03	0.20300	-0.201000	-2.76e-02	4.76e-03	6.98e-01
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA	50	9.96e-05	1.22e-03	0.30800	-0.286000	-1.13e-01	4.63e-04	1.68e-01
HS-GAG-biosynthesis	23	1.16e-04	1.41e-03	0.47500	0.434000	1.92e-01	3.13e-04	1.12e-01
Negative-regulation-of-NOTCH4-signaling	51	1.22e-04	1.47e-03	0.31800	-0.291000	-1.28e-01	3.29e-04	1.14e-01
MET-activates-PTK2-signaling	17	1.25e-04	1.50e-03	0.74900	0.593000	4.58e-01	2.33e-05	1.08e-03
G2/M-Checkpoints	125	1.43e-04	1.68e-03	0.09520	-0.065300	6.92e-02	2.08e-01	1.82e-01
Regulation-of-RUNX2-expression-and-activity	66	1.43e-04	1.68e-03	0.24600	-0.233000	-7.79e-02	1.08e-03	2.74e-01
Response-to-elevated-platelet-cytosolic-Ca2+	113	1.45e-04	1.69e-03	0.29600	0.229000	1.88e-01	2.63e-05	5.63e-04
Mitochondrial-calcium-ion-transport	21	1.53e-04	1.76e-03	0.71000	-0.495000	-5.09e-01	8.64e-05	5.32e-05
Glucose-metabolism	79	1.57e-04	1.78e-03	0.33300	-0.195000	-2.70e-01	2.73e-03	3.44e-05
Collagen-degradation	26	1.57e-04	1.78e-03	0.60000	0.473000	3.68e-01	2.93e-05	1.17e-03
Class-I-peroxisomal-membrane-protein-import	19	1.70e-04	1.90e-03	0.66000	-0.377000	-5.42e-01	4.41e-03	4.30e-05
FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis	51	1.71e-04	1.90e-03	0.31800	-0.289000	-1.32e-01	3.60e-04	1.04e-01
Ubiquitin-dependent-degradation-of-Cyclin-D	48	1.72e-04	1.90e-03	0.28800	-0.272000	-9.36e-02	1.11e-03	2.62e-01
Degradation-of-GLI1-by-the-proteasome	55	1.82e-04	1.99e-03	0.33100	-0.292000	-1.55e-01	1.78e-04	4.67e-02
Regulation-of-lipid-metabolism-by-PPARalpha	111	1.88e-04	2.04e-03	0.28200	-0.168000	-2.26e-01	2.28e-03	3.88e-05
PPARA-activates-gene-expression	109	1.93e-04	2.08e-03	0.28600	-0.172000	-2.28e-01	1.94e-03	3.85e-05
Defects-in-vitamin-and-cofactor-metabolism	20	1.95e-04	2.08e-03	0.69900	-0.452000	-5.33e-01	4.61e-04	3.72e-05
O-glycosylation-of-TSR-domain-containing-proteins	33	1.99e-04	2.10e-03	0.54400	0.414000	3.52e-01	3.79e-05	4.70e-04
Signaling-by-MET	60	2.20e-04	2.31e-03	0.33400	0.287000	1.70e-01	1.19e-04	2.28e-02
Platelet-activation,-signaling-and-aggregation	214	2.24e-04	2.33e-03	0.21500	0.162000	1.41e-01	4.52e-05	3.93e-04
N-glycan-antennae-elongation-in-the-medial/trans-Golgi	20	2.41e-04	2.49e-03	0.35500	0.351000	5.31e-02	6.62e-03	6.81e-01
tRNA-processing	116	2.53e-04	2.59e-03	0.29500	-0.208000	-2.08e-01	1.08e-04	1.08e-04
Degradation-of-AXIN	51	2.92e-04	2.94e-03	0.27600	-0.259000	-9.33e-02	1.36e-03	2.49e-01
EPH-Ephrin-signaling	82	2.92e-04	2.94e-03	0.31200	0.254000	1.80e-01	6.99e-05	4.81e-03
Degradation-of-DVL	52	2.99e-04	2.99e-03	0.33300	-0.293000	-1.58e-01	2.56e-04	4.90e-02
Metabolism-of-carbohydrates	237	3.16e-04	3.13e-03	0.10400	0.102000	1.71e-02	6.78e-03	6.50e-01
CS/DS-degradation	11	3.22e-04	3.17e-03	0.92800	0.620000	6.91e-01	3.74e-04	7.28e-05
Protein-ubiquitination	62	3.31e-04	3.24e-03	0.15600	0.022200	-1.54e-01	7.62e-01	3.60e-02
Sulfur-amino-acid-metabolism	20	3.47e-04	3.35e-03	0.69100	-0.475000	-5.02e-01	2.39e-04	1.00e-04
Fcgamma-receptor-(FCGR)-dependent-phagocytosis	82	3.49e-04	3.35e-03	0.33200	0.213000	2.55e-01	8.87e-04	6.69e-05
RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs	64	3.53e-04	3.37e-03	0.23000	-0.219000	-6.80e-02	2.40e-03	3.47e-01
Regulation-of-PTEN-stability-and-activity	65	3.58e-04	3.39e-03	0.28300	-0.253000	-1.27e-01	4.21e-04	7.71e-02
Hh-mutants-abrogate-ligand-secretion	53	3.99e-04	3.74e-03	0.29200	-0.267000	-1.19e-01	7.77e-04	1.34e-01
Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS)	32	4.00e-04	3.74e-03	0.53500	0.401000	3.55e-01	8.77e-05	5.08e-04
The-canonical-retinoid-cycle-in-rods-(twilight-vision)	12	4.09e-04	3.79e-03	0.60900	0.245000	5.57e-01	1.41e-01	8.31e-04
Hh-mutants-that-don't-undergo-autocatalytic-processing-are-degraded-by-ERAD	51	4.47e-04	4.11e-03	0.31700	-0.283000	-1.43e-01	4.82e-04	7.68e-02
Mitophagy	27	4.58e-04	4.17e-03	0.58200	-0.429000	-3.94e-01	1.16e-04	3.92e-04
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha	60	4.60e-04	4.17e-03	0.32300	-0.276000	-1.67e-01	2.17e-04	2.57e-02
HS-GAG-degradation	18	4.70e-04	4.23e-03	0.52600	0.471000	2.34e-01	5.46e-04	8.52e-02
Defective-CFTR-causes-cystic-fibrosis	55	4.89e-04	4.38e-03	0.32000	-0.280000	-1.56e-01	3.33e-04	4.53e-02
Cross-presentation-of-soluble-exogenous-antigens-(endosomes)	44	5.19e-04	4.61e-03	0.28900	-0.271000	-1.00e-01	1.86e-03	2.50e-01
Heme-biosynthesis	12	5.39e-04	4.76e-03	0.86800	-0.601000	-6.27e-01	3.12e-04	1.70e-04
ER-Phagosome-pathway	73	5.67e-04	4.97e-03	0.17000	-0.169000	-1.98e-02	1.25e-02	7.70e-01
NIK-->noncanonical-NF-kB-signaling	55	5.97e-04	5.19e-03	0.28000	-0.256000	-1.15e-01	1.03e-03	1.41e-01
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein	69	6.68e-04	5.77e-03	0.14300	0.142000	-1.72e-02	4.15e-02	8.04e-01
Signaling-by-PDGF	48	6.72e-04	5.77e-03	0.42600	0.313000	2.89e-01	1.75e-04	5.29e-04
Keratan-sulfate-degradation	10	6.99e-04	5.96e-03	0.93200	0.680000	6.38e-01	1.95e-04	4.80e-04
Cytokine-Signaling-in-Immune-system	610	7.31e-04	6.19e-03	0.11800	0.075700	9.06e-02	1.52e-03	1.46e-04
Kinesins	35	8.36e-04	7.04e-03	0.48800	0.364000	3.25e-01	1.92e-04	8.91e-04
Crosslinking-of-collagen-fibrils	10	8.72e-04	7.29e-03	0.88700	0.685000	5.63e-01	1.75e-04	2.06e-03
Disease	881	8.96e-04	7.40e-03	0.05530	0.053800	1.28e-02	7.31e-03	5.24e-01
Cellular-response-to-hypoxia	68	8.97e-04	7.40e-03	0.29000	-0.248000	-1.50e-01	4.10e-04	3.31e-02
UCH-proteinases	80	9.06e-04	7.42e-03	0.17800	-0.173000	-4.07e-02	7.49e-03	5.30e-01
GLI3-is-processed-to-GLI3R-by-the-proteasome	55	9.59e-04	7.81e-03	0.30000	-0.264000	-1.43e-01	7.06e-04	6.74e-02
p53-Dependent-G1-DNA-Damage-Response	59	9.94e-04	8.00e-03	0.21900	-0.210000	-6.14e-02	5.29e-03	4.15e-01
p53-Dependent-G1/S-DNA-damage-checkpoint	59	9.94e-04	8.00e-03	0.21900	-0.210000	-6.14e-02	5.29e-03	4.15e-01
RAB-geranylgeranylation	51	1.00e-03	8.01e-03	0.14800	0.142000	-4.10e-02	8.01e-02	6.13e-01
Degradation-of-GLI2-by-the-proteasome	55	1.02e-03	8.12e-03	0.29600	-0.261000	-1.39e-01	8.06e-04	7.55e-02
Dectin-1-mediated-noncanonical-NF-kB-signaling	56	1.08e-03	8.56e-03	0.26100	-0.240000	-1.03e-01	1.94e-03	1.84e-01
Defects-in-cobalamin-(B12)-metabolism	12	1.10e-03	8.65e-03	0.82300	-0.562000	-6.02e-01	7.53e-04	3.04e-04
Termination-of-O-glycan-biosynthesis	10	1.12e-03	8.70e-03	0.39100	0.391000	-5.26e-03	3.24e-02	9.77e-01
Regulation-of-RAS-by-GAPs	63	1.17e-03	9.04e-03	0.19800	-0.193000	-4.70e-02	8.17e-03	5.19e-01
Signaling-by-TGF-beta-family-members	88	1.19e-03	9.19e-03	0.22200	0.199000	9.81e-02	1.25e-03	1.12e-01
Pink/Parkin-Mediated-Mitophagy	20	1.23e-03	9.40e-03	0.61600	-0.473000	-3.94e-01	2.54e-04	2.26e-03
Post-NMDA-receptor-activation-events	50	1.31e-03	9.94e-03	0.13600	0.122000	-6.09e-02	1.36e-01	4.56e-01
Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer	43	1.40e-03	1.06e-02	0.27900	0.260000	1.02e-01	3.18e-03	2.50e-01
Metabolism-of-polyamines	53	1.43e-03	1.08e-02	0.22100	-0.213000	-5.86e-02	7.45e-03	4.61e-01
Carnitine-metabolism	12	1.61e-03	1.21e-02	0.76400	-0.476000	-5.98e-01	4.31e-03	3.37e-04
Activation-of-NF-kappaB-in-B-cells	62	1.68e-03	1.25e-02	0.19600	-0.190000	-4.75e-02	9.72e-03	5.18e-01
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint	55	1.73e-03	1.27e-02	0.17900	-0.178000	-1.90e-02	2.23e-02	8.08e-01
Synaptic-adhesion-like-molecules	15	1.73e-03	1.27e-02	0.28500	0.283000	-3.47e-02	5.76e-02	8.16e-01
G1/S-DNA-Damage-Checkpoints	61	1.77e-03	1.29e-02	0.20500	-0.197000	-5.66e-02	7.84e-03	4.45e-01
A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis	21	1.81e-03	1.31e-02	0.55000	0.444000	3.24e-01	4.28e-04	1.01e-02
Intraflagellar-transport	36	1.85e-03	1.33e-02	0.43500	0.342000	2.69e-01	3.92e-04	5.28e-03
Signaling-by-Retinoic-Acid	32	1.88e-03	1.35e-02	0.47000	-0.300000	-3.62e-01	3.36e-03	3.98e-04
FCERI-mediated-NF-kB-activation	73	1.92e-03	1.38e-02	0.25700	-0.223000	-1.29e-01	1.01e-03	5.75e-02
p130Cas-linkage-to-MAPK-signaling-for-integrins	14	1.95e-03	1.38e-02	0.70400	0.545000	4.46e-01	4.11e-04	3.88e-03
Mitotic-Prometaphase	174	1.97e-03	1.39e-02	0.16800	0.145000	8.42e-02	1.00e-03	5.59e-02
Presynaptic-depolarization-and-calcium-channel-opening	10	2.06e-03	1.45e-02	0.39600	0.022500	3.95e-01	9.02e-01	3.06e-02
Gene-expression-(Transcription)	1076	2.07e-03	1.45e-02	0.06540	-0.030400	-5.78e-02	9.59e-02	1.55e-03
Neddylation	210	2.19e-03	1.51e-02	0.18900	-0.135000	-1.32e-01	7.60e-04	1.01e-03
Defective-B3GALT6-causes-EDSP2-and-SEMDJL1	16	2.19e-03	1.51e-02	0.64400	0.505000	4.00e-01	4.69e-04	5.66e-03
Metabolism-of-vitamins-and-cofactors	153	2.20e-03	1.51e-02	0.21800	-0.145000	-1.63e-01	2.06e-03	5.27e-04
Potassium-Channels	56	2.20e-03	1.51e-02	0.28900	-0.251000	-1.44e-01	1.17e-03	6.24e-02
ER-to-Golgi-Anterograde-Transport	120	2.34e-03	1.60e-02	0.08030	0.055100	-5.85e-02	2.98e-01	2.69e-01
Signaling-by-TGF-beta-Receptor-Complex	71	2.37e-03	1.60e-02	0.19400	0.184000	6.02e-02	7.28e-03	3.81e-01
RNA-Polymerase-II-Transcription	957	2.44e-03	1.64e-02	0.06990	-0.033700	-6.12e-02	8.07e-02	1.51e-03
Hedgehog-ligand-biogenesis	56	2.45e-03	1.64e-02	0.23700	-0.220000	-8.77e-02	4.49e-03	2.56e-01
HCMV-Infection	80	2.50e-03	1.65e-02	0.11500	0.113000	-2.17e-02	8.02e-02	7.37e-01
Chemokine-receptors-bind-chemokines	20	2.50e-03	1.65e-02	0.30300	0.299000	4.74e-02	2.05e-02	7.14e-01
Regulation-of-RUNX3-expression-and-activity	52	2.51e-03	1.65e-02	0.17700	-0.176000	-1.65e-02	2.83e-02	8.37e-01
Regulation-of-actin-dynamics-for-phagocytic-cup-formation	59	2.59e-03	1.70e-02	0.35000	0.246000	2.49e-01	1.10e-03	9.59e-04
EPHB-mediated-forward-signaling	32	2.71e-03	1.77e-02	0.46900	0.346000	3.16e-01	7.13e-04	1.97e-03
SCF(Skp2)-mediated-degradation-of-p27/p21	57	2.76e-03	1.79e-02	0.21800	-0.206000	-7.12e-02	7.12e-03	3.53e-01
Signaling-by-the-B-Cell-Receptor-(BCR)	103	2.88e-03	1.86e-02	0.12400	-0.124000	-1.17e-02	3.00e-02	8.37e-01
Keratan-sulfate/keratin-metabolism	27	3.04e-03	1.95e-02	0.50000	0.376000	3.29e-01	7.15e-04	3.07e-03
Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements	83	3.05e-03	1.95e-02	0.19800	-0.182000	-7.82e-02	4.26e-03	2.19e-01
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes	29	3.25e-03	2.07e-02	0.22500	-0.014700	-2.25e-01	8.91e-01	3.62e-02
Sialic-acid-metabolism	26	3.27e-03	2.07e-02	0.23900	0.238000	1.68e-02	3.55e-02	8.82e-01
Synthesis-of-substrates-in-N-glycan-biosythesis	56	3.48e-03	2.19e-02	0.17200	0.171000	2.30e-02	2.73e-02	7.66e-01
Diseases-associated-with-O-glycosylation-of-proteins	46	3.63e-03	2.28e-02	0.38400	0.276000	2.68e-01	1.23e-03	1.70e-03
Synthesis-of-PIPs-at-the-plasma-membrane	51	3.76e-03	2.34e-02	0.27200	0.242000	1.24e-01	2.84e-03	1.25e-01
Metabolism-of-water-soluble-vitamins-and-cofactors	103	3.97e-03	2.46e-02	0.25000	-0.163000	-1.89e-01	4.25e-03	9.27e-04
Macroautophagy	99	4.33e-03	2.67e-02	0.23200	-0.134000	-1.89e-01	2.17e-02	1.16e-03
Regulation-of-PTEN-gene-transcription	59	4.45e-03	2.74e-02	0.17400	-0.033100	-1.71e-01	6.61e-01	2.33e-02
Signaling-by-NOTCH4	78	4.53e-03	2.78e-02	0.21000	-0.189000	-9.23e-02	3.95e-03	1.59e-01
mTOR-signalling	37	4.57e-03	2.78e-02	0.40300	-0.254000	-3.12e-01	7.41e-03	1.03e-03
Senescence-Associated-Secretory-Phenotype-(SASP)	45	5.00e-03	3.03e-02	0.27200	0.245000	1.18e-01	4.48e-03	1.71e-01
Activation-of-the-pre-replicative-complex	32	5.28e-03	3.18e-02	0.24700	0.059900	2.39e-01	5.58e-01	1.91e-02
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2	13	5.29e-03	3.18e-02	0.49200	0.446000	2.06e-01	5.33e-03	1.98e-01
mTORC1-mediated-signalling	20	5.39e-03	3.22e-02	0.55000	-0.361000	-4.15e-01	5.17e-03	1.30e-03
Peptide-ligand-binding-receptors	57	5.45e-03	3.23e-02	0.13700	0.136000	-1.06e-02	7.50e-02	8.90e-01
Downstream-TCR-signaling	77	5.45e-03	3.23e-02	0.20400	-0.185000	-8.74e-02	5.10e-03	1.85e-01
Metabolism-of-porphyrins	19	5.53e-03	3.25e-02	0.55100	-0.348000	-4.27e-01	8.69e-03	1.26e-03
Defective-B3GAT3-causes-JDSSDHD	16	5.53e-03	3.25e-02	0.58600	0.464000	3.57e-01	1.30e-03	1.34e-02
Defective-B4GALT7-causes-EDS,-progeroid-type	16	5.72e-03	3.32e-02	0.57100	0.460000	3.38e-01	1.44e-03	1.94e-02
Prolactin-receptor-signaling	11	5.73e-03	3.32e-02	0.73100	-0.472000	-5.59e-01	6.73e-03	1.34e-03
Intra-Golgi-traffic	41	5.73e-03	3.32e-02	0.16800	0.168000	-2.91e-03	6.30e-02	9.74e-01
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity	23	6.01e-03	3.47e-02	0.25000	0.248000	2.80e-02	3.95e-02	8.17e-01
Transcriptional-Regulation-by-TP53	334	6.12e-03	3.51e-02	0.13500	-0.101000	-8.84e-02	1.50e-03	5.66e-03
Activation-of-SMO	15	6.16e-03	3.52e-02	0.59700	0.362000	4.74e-01	1.52e-02	1.47e-03
Formation-of-Incision-Complex-in-GG-NER	43	6.52e-03	3.71e-02	0.29600	-0.145000	-2.58e-01	9.92e-02	3.44e-03
APC/C:Cdc20-mediated-degradation-of-Securin	62	6.76e-03	3.83e-02	0.23600	-0.209000	-1.09e-01	4.50e-03	1.37e-01
TNFs-bind-their-physiological-receptors	12	6.81e-03	3.84e-02	0.60900	0.334000	5.09e-01	4.52e-02	2.25e-03
Sphingolipid-metabolism	67	6.93e-03	3.89e-02	0.25400	0.214000	1.37e-01	2.45e-03	5.24e-02
Interferon-gamma-signaling	58	7.00e-03	3.91e-02	0.25000	0.121000	2.19e-01	1.12e-01	3.95e-03
Innate-Immune-System	746	7.02e-03	3.91e-02	0.09130	0.067000	6.21e-02	2.01e-03	4.21e-03
Glutamate-Neurotransmitter-Release-Cycle	18	7.24e-03	4.01e-02	0.51100	0.292000	4.20e-01	3.19e-02	2.05e-03
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT)	30	7.64e-03	4.20e-02	0.22900	0.225000	4.12e-02	3.28e-02	6.96e-01
Transport-of-small-molecules	492	7.64e-03	4.20e-02	0.10700	-0.067200	-8.26e-02	1.11e-02	1.80e-03
DARPP-32-events	22	7.90e-03	4.31e-02	0.39500	-0.187000	-3.48e-01	1.29e-01	4.75e-03
COPII-mediated-vesicle-transport	58	7.93e-03	4.31e-02	0.11000	0.043800	-1.01e-01	5.65e-01	1.85e-01
Deubiquitination	220	8.02e-03	4.35e-02	0.06250	-0.061300	1.21e-02	1.18e-01	7.58e-01
Cellular-responses-to-stress	435	8.10e-03	4.37e-02	0.11600	-0.078600	-8.58e-02	5.16e-03	2.26e-03
Synthesis-of-PA	27	8.76e-03	4.70e-02	0.46000	-0.331000	-3.19e-01	2.91e-03	4.10e-03
NCAM1-interactions	30	8.78e-03	4.70e-02	0.43700	0.308000	3.10e-01	3.50e-03	3.34e-03
DNA-strand-elongation	31	8.91e-03	4.73e-02	0.30500	0.130000	2.76e-01	2.12e-01	7.85e-03
Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism	13	8.93e-03	4.73e-02	0.65900	-0.450000	-4.81e-01	4.98e-03	2.66e-03
Autophagy	110	8.95e-03	4.73e-02	0.19600	-0.108000	-1.64e-01	5.14e-02	2.97e-03
Interferon-Signaling	141	9.06e-03	4.77e-02	0.10800	0.023500	1.06e-01	6.31e-01	3.03e-02
Smooth-Muscle-Contraction	31	9.21e-03	4.83e-02	0.21300	0.031400	2.11e-01	7.62e-01	4.21e-02
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes	23	9.53e-03	4.97e-02	0.16200	0.095500	-1.31e-01	4.28e-01	2.77e-01
GRB2:SOS-provides-linkage-to-MAPK-signaling-for-Integrins	14	9.96e-03	5.17e-02	0.58800	0.467000	3.57e-01	2.47e-03	2.06e-02
Chromatin-modifying-enzymes	194	1.00e-02	5.17e-02	0.08700	-0.014700	-8.57e-02	7.24e-01	4.00e-02
Chromatin-organization	194	1.00e-02	5.17e-02	0.08700	-0.014700	-8.57e-02	7.24e-01	4.00e-02
Cellular-responses-to-external-stimuli	438	1.01e-02	5.19e-02	0.11300	-0.075100	-8.40e-02	7.30e-03	2.70e-03
SMAD2/SMAD3:SMAD4-heterotrimer-regulates-transcription	31	1.02e-02	5.21e-02	0.32400	0.285000	1.53e-01	6.02e-03	1.40e-01
Activation-of-Matrix-Metalloproteinases	17	1.06e-02	5.40e-02	0.51300	0.417000	2.98e-01	2.91e-03	3.33e-02
Hedgehog-'on'-state	77	1.07e-02	5.42e-02	0.08920	-0.045400	7.67e-02	4.91e-01	2.45e-01
Unwinding-of-DNA	12	1.08e-02	5.44e-02	0.55600	0.289000	4.75e-01	8.30e-02	4.40e-03
Semaphorin-interactions	61	1.09e-02	5.51e-02	0.29600	0.197000	2.20e-01	7.77e-03	2.94e-03
PTEN-Regulation	135	1.10e-02	5.52e-02	0.20200	-0.142000	-1.43e-01	4.35e-03	4.22e-03
Retrograde-transport-at-the-Trans-Golgi-Network	46	1.11e-02	5.52e-02	0.11300	0.064400	-9.32e-02	4.50e-01	2.75e-01
Phospholipid-metabolism	179	1.12e-02	5.59e-02	0.14800	-0.079900	-1.25e-01	6.56e-02	4.00e-03
Activation-of-gene-expression-by-SREBF-(SREBP)	42	1.14e-02	5.66e-02	0.31600	-0.178000	-2.61e-01	4.60e-02	3.47e-03
Clathrin-mediated-endocytosis	121	1.15e-02	5.70e-02	0.14100	0.131000	5.42e-02	1.32e-02	3.04e-01
L1CAM-interactions	82	1.16e-02	5.72e-02	0.20800	0.179000	1.06e-01	5.12e-03	9.69e-02
Rho-GTPase-cycle	130	1.17e-02	5.73e-02	0.18600	0.110000	1.50e-01	3.09e-02	3.12e-03
Signal-transduction-by-L1	21	1.19e-02	5.83e-02	0.38800	0.341000	1.85e-01	6.77e-03	1.42e-01
Resolution-of-Sister-Chromatid-Cohesion	95	1.20e-02	5.83e-02	0.20700	0.172000	1.16e-01	3.79e-03	5.18e-02
TRAF3-dependent-IRF-activation-pathway	12	1.23e-02	5.94e-02	0.28800	-0.002980	2.88e-01	9.86e-01	8.43e-02
Glycogen-metabolism	25	1.24e-02	5.97e-02	0.45900	-0.333000	-3.16e-01	3.93e-03	6.21e-03
Signaling-by-Activin	11	1.25e-02	6.00e-02	0.33500	0.333000	3.84e-02	5.60e-02	8.25e-01
Integrin-signaling	26	1.29e-02	6.17e-02	0.42500	0.334000	2.62e-01	3.20e-03	2.06e-02
Defective-EXT1-causes-exostoses-1,-TRPS2-and-CHDS	12	1.31e-02	6.22e-02	0.47700	0.430000	2.08e-01	9.98e-03	2.12e-01
Defective-EXT2-causes-exostoses-2	12	1.31e-02	6.22e-02	0.47700	0.430000	2.08e-01	9.98e-03	2.12e-01
Processing-of-SMDT1	15	1.32e-02	6.27e-02	0.58100	-0.385000	-4.35e-01	9.78e-03	3.54e-03
DNA-Replication	119	1.33e-02	6.29e-02	0.06840	-0.052900	4.34e-02	3.20e-01	4.14e-01
TNFR2-non-canonical-NF-kB-pathway	76	1.34e-02	6.31e-02	0.08670	-0.072700	4.73e-02	2.74e-01	4.77e-01
RHO-GTPases-Activate-Formins	110	1.35e-02	6.33e-02	0.21800	0.154000	1.55e-01	5.44e-03	5.08e-03
Activation-of-NMDA-receptors-and-postsynaptic-events	59	1.36e-02	6.36e-02	0.13200	0.132000	3.04e-03	7.97e-02	9.68e-01
Developmental-Biology	654	1.38e-02	6.40e-02	0.04480	0.044400	6.05e-03	5.45e-02	7.93e-01
EPHA-mediated-growth-cone-collapse	14	1.40e-02	6.47e-02	0.45900	0.213000	4.06e-01	1.67e-01	8.54e-03
Autodegradation-of-Cdh1-by-Cdh1:APC/C	60	1.41e-02	6.49e-02	0.22000	-0.195000	-1.02e-01	8.87e-03	1.74e-01
Hyaluronan-metabolism	15	1.41e-02	6.49e-02	0.54300	0.327000	4.33e-01	2.84e-02	3.66e-03
Glycolysis	63	1.43e-02	6.57e-02	0.23600	-0.124000	-2.01e-01	8.98e-02	5.71e-03
Synthesis-of-DNA	112	1.44e-02	6.58e-02	0.07510	-0.070000	2.74e-02	2.01e-01	6.17e-01
Voltage-gated-Potassium-channels	22	1.44e-02	6.58e-02	0.45900	-0.359000	-2.87e-01	3.61e-03	2.00e-02
Ub-specific-processing-proteases	151	1.46e-02	6.62e-02	0.10100	-0.098100	-2.31e-02	3.77e-02	6.25e-01
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers	29	1.48e-02	6.71e-02	0.14800	-0.051000	1.39e-01	6.34e-01	1.96e-01
RHO-GTPases-Activate-ROCKs	18	1.49e-02	6.71e-02	0.43800	0.228000	3.74e-01	9.39e-02	6.03e-03
Apoptotic-cleavage-of-cellular-proteins	34	1.50e-02	6.72e-02	0.33500	0.279000	1.86e-01	4.86e-03	6.05e-02
Signaling-by-Hippo	20	1.54e-02	6.89e-02	0.48400	0.373000	3.09e-01	3.88e-03	1.67e-02
Switching-of-origins-to-a-post-replicative-state	84	1.58e-02	7.03e-02	0.12700	-0.125000	-2.36e-02	4.79e-02	7.09e-01
PI-Metabolism	78	1.61e-02	7.16e-02	0.15700	0.149000	5.23e-02	2.35e-02	4.25e-01
Keratan-sulfate-biosynthesis	22	1.62e-02	7.16e-02	0.47100	0.349000	3.15e-01	4.55e-03	1.05e-02
HDACs-deacetylate-histones	31	1.63e-02	7.18e-02	0.13200	0.107000	-7.60e-02	3.01e-01	4.64e-01
mRNA-Splicing---Minor-Pathway	51	1.65e-02	7.25e-02	0.28600	-0.230000	-1.69e-01	4.47e-03	3.65e-02
TNF-receptor-superfamily-(TNFSF)-members-mediating-non-canonical-NF-kB-pathway	11	1.67e-02	7.30e-02	0.66500	0.491000	4.48e-01	4.83e-03	1.01e-02
IRE1alpha-activates-chaperones	50	1.69e-02	7.37e-02	0.11500	0.111000	-3.08e-02	1.75e-01	7.06e-01
MHC-class-II-antigen-presentation	82	1.72e-02	7.47e-02	0.18900	0.166000	8.99e-02	9.51e-03	1.60e-01
G1/S-Transition	126	1.72e-02	7.47e-02	0.06660	-0.058500	3.19e-02	2.57e-01	5.37e-01
Selective-autophagy	50	1.73e-02	7.49e-02	0.31100	-0.229000	-2.11e-01	5.14e-03	9.95e-03
Glycosphingolipid-metabolism	34	1.75e-02	7.52e-02	0.32000	0.270000	1.71e-01	6.41e-03	8.38e-02
Asymmetric-localization-of-PCP-proteins	60	1.78e-02	7.65e-02	0.21000	-0.188000	-9.46e-02	1.19e-02	2.05e-01
CDK-mediated-phosphorylation-and-removal-of-Cdc6	66	1.82e-02	7.77e-02	0.19200	-0.174000	-8.07e-02	1.47e-02	2.57e-01
Antigen-processing-Cross-presentation	85	1.88e-02	8.03e-02	0.08430	-0.079300	2.87e-02	2.07e-01	6.48e-01
RUNX1-interacts-with-co-factors-whose-precise-effect-on-RUNX1-targets-is-not-known	36	1.90e-02	8.07e-02	0.12700	0.118000	-4.79e-02	2.21e-01	6.19e-01
Protein-protein-interactions-at-synapses	61	1.93e-02	8.18e-02	0.21600	0.190000	1.03e-01	1.05e-02	1.64e-01
Mucopolysaccharidoses	11	1.94e-02	8.18e-02	0.62400	0.489000	3.88e-01	4.99e-03	2.60e-02
Generic-Transcription-Pathway	843	1.96e-02	8.23e-02	0.05800	-0.026700	-5.15e-02	1.92e-01	1.20e-02
RORA-activates-gene-expression	18	1.96e-02	8.24e-02	0.36600	-0.157000	-3.31e-01	2.50e-01	1.50e-02
APC/C:Cdh1-mediated-degradation-of-Cdc20-and-other-APC/C:Cdh1-targeted-proteins-in-late-mitosis/early-G1	67	2.07e-02	8.67e-02	0.18200	-0.167000	-7.39e-02	1.83e-02	2.96e-01
mRNA-3'-end-processing	54	2.11e-02	8.77e-02	0.29400	-0.212000	-2.03e-01	6.95e-03	1.01e-02
Signaling-by-NTRKs	91	2.16e-02	8.99e-02	0.09560	0.095600	-3.74e-03	1.15e-01	9.51e-01
Host-Interactions-of-HIV-factors	114	2.21e-02	9.10e-02	0.19200	-0.150000	-1.20e-01	5.75e-03	2.65e-02
RNA-Polymerase-II-Transcription-Termination	62	2.21e-02	9.10e-02	0.27100	-0.183000	-2.00e-01	1.26e-02	6.62e-03
FOXO-mediated-transcription-of-cell-cycle-genes	14	2.24e-02	9.20e-02	0.21700	0.043700	-2.13e-01	7.77e-01	1.68e-01
Anchoring-of-the-basal-body-to-the-plasma-membrane	96	2.26e-02	9.25e-02	0.17600	0.152000	8.92e-02	1.01e-02	1.31e-01
Degradation-of-beta-catenin-by-the-destruction-complex	81	2.28e-02	9.29e-02	0.18600	-0.163000	-9.06e-02	1.15e-02	1.59e-01
Sema4D-in-semaphorin-signaling	23	2.28e-02	9.29e-02	0.40700	0.240000	3.28e-01	4.64e-02	6.42e-03
Peptide-hormone-metabolism	51	2.32e-02	9.42e-02	0.19100	0.179000	6.78e-02	2.71e-02	4.03e-01
Transport-of-Mature-Transcript-to-Cytoplasm	78	2.42e-02	9.79e-02	0.24000	-0.164000	-1.75e-01	1.23e-02	7.74e-03
BMAL1:CLOCK,NPAS2-activates-circadian-gene-expression	25	2.45e-02	9.87e-02	0.27300	-0.097700	-2.55e-01	3.98e-01	2.75e-02
Hyaluronan-uptake-and-degradation	11	2.47e-02	9.95e-02	0.63400	0.431000	4.64e-01	1.32e-02	7.70e-03
FOXO-mediated-transcription-of-cell-death-genes	14	2.48e-02	9.96e-02	0.40500	-0.366000	-1.75e-01	1.79e-02	2.57e-01
Cell-cell-junction-organization	33	2.53e-02	1.01e-01	0.13800	0.135000	-2.99e-02	1.80e-01	7.66e-01
Factors-involved-in-megakaryocyte-development-and-platelet-production	104	2.57e-02	1.02e-01	0.19100	0.153000	1.14e-01	7.14e-03	4.51e-02
CLEC7A-(Dectin-1)-signaling	92	2.57e-02	1.02e-01	0.14900	-0.137000	-5.85e-02	2.34e-02	3.33e-01
Cell-Cycle-Checkpoints	233	2.67e-02	1.05e-01	0.09680	0.040300	8.80e-02	2.90e-01	2.09e-02
Downstream-signaling-events-of-B-Cell-Receptor-(BCR)	75	2.67e-02	1.05e-01	0.17700	-0.158000	-7.82e-02	1.78e-02	2.42e-01
Mitotic-Spindle-Checkpoint	98	2.73e-02	1.07e-01	0.18100	0.152000	9.91e-02	9.52e-03	9.05e-02
Signaling-by-high-kinase-activity-BRAF-mutants	31	2.73e-02	1.07e-01	0.37300	0.272000	2.55e-01	8.73e-03	1.40e-02
Interleukin-1-signaling	90	2.77e-02	1.08e-01	0.12500	-0.120000	-3.26e-02	4.86e-02	5.93e-01
Interleukin-12-family-signaling	37	2.80e-02	1.09e-01	0.19700	0.189000	5.37e-02	4.65e-02	5.72e-01
E3-ubiquitin-ligases-ubiquitinate-target-proteins	42	2.82e-02	1.09e-01	0.15100	-0.013200	-1.50e-01	8.82e-01	9.20e-02
Nephrin-family-interactions	18	2.82e-02	1.09e-01	0.34800	0.148000	3.15e-01	2.77e-01	2.08e-02
XBP1(S)-activates-chaperone-genes	48	2.87e-02	1.11e-01	0.11900	0.117000	-1.57e-02	1.59e-01	8.51e-01
EML4-and-NUDC-in-mitotic-spindle-formation	87	2.89e-02	1.11e-01	0.20700	0.165000	1.25e-01	7.97e-03	4.37e-02
Cdc20:Phospho-APC/C-mediated-degradation-of-Cyclin-A	65	2.91e-02	1.12e-01	0.17000	-0.157000	-6.38e-02	2.85e-02	3.74e-01
STING-mediated-induction-of-host-immune-responses	14	2.96e-02	1.13e-01	0.28200	0.047900	2.77e-01	7.56e-01	7.23e-02
Muscle-contraction	148	2.98e-02	1.14e-01	0.05550	-0.043800	3.41e-02	3.59e-01	4.74e-01
HCMV-Late-Events	54	2.98e-02	1.14e-01	0.10100	0.096000	-3.10e-02	2.23e-01	6.94e-01
Aflatoxin-activation-and-detoxification	10	3.02e-02	1.14e-01	0.60700	-0.369000	-4.82e-01	4.34e-02	8.32e-03
Apoptotic-execution-phase	41	3.03e-02	1.15e-01	0.21900	0.201000	8.66e-02	2.63e-02	3.38e-01
Signaling-by-BMP	18	3.07e-02	1.16e-01	0.48000	0.325000	3.53e-01	1.69e-02	9.49e-03
Platelet-Aggregation-(Plug-Formation)	29	3.11e-02	1.17e-01	0.38000	0.266000	2.71e-01	1.30e-02	1.15e-02
Inflammasomes	18	3.15e-02	1.18e-01	0.47000	0.306000	3.57e-01	2.47e-02	8.75e-03
Cellular-response-to-heat-stress	91	3.22e-02	1.20e-01	0.21000	-0.158000	-1.37e-01	9.07e-03	2.36e-02
MAPK-targets/-Nuclear-events-mediated-by-MAP-kinases	30	3.27e-02	1.22e-01	0.19700	-0.040400	-1.93e-01	7.02e-01	6.76e-02
APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	68	3.28e-02	1.22e-01	0.15800	-0.148000	-5.59e-02	3.52e-02	4.25e-01
Signaling-by-EGFR	45	3.35e-02	1.24e-01	0.22800	0.202000	1.06e-01	1.91e-02	2.20e-01
Organelle-biogenesis-and-maintenance	264	3.42e-02	1.26e-01	0.09840	-0.048200	-8.58e-02	1.79e-01	1.67e-02
Regulation-of-cholesterol-biosynthesis-by-SREBP-(SREBF)	53	3.44e-02	1.27e-01	0.18900	-0.074600	-1.73e-01	3.48e-01	2.93e-02
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint	66	3.61e-02	1.33e-01	0.15600	-0.147000	-5.41e-02	3.94e-02	4.47e-01
Cellular-Senescence	118	3.67e-02	1.34e-01	0.06250	0.055400	-2.87e-02	2.99e-01	5.90e-01
Cell-extracellular-matrix-interactions	16	3.67e-02	1.34e-01	0.40200	0.203000	3.47e-01	1.60e-01	1.64e-02
Interleukin-12-signaling	31	3.71e-02	1.35e-01	0.15700	0.157000	1.18e-03	1.30e-01	9.91e-01
Interleukin-10-signaling	23	3.81e-02	1.39e-01	0.34000	0.291000	1.76e-01	1.59e-02	1.45e-01
Mitotic-G1-phase-and-G1/S-transition	143	3.90e-02	1.41e-01	0.05890	-0.019900	5.55e-02	6.82e-01	2.53e-01
Antimicrobial-peptides	13	3.99e-02	1.44e-01	0.25400	0.254000	1.88e-02	1.14e-01	9.07e-01
Caspase-activation-via-extrinsic-apoptotic-signalling-pathway	22	4.06e-02	1.46e-01	0.39700	0.312000	2.46e-01	1.14e-02	4.57e-02
Signaling-by-BRAF-and-RAF-fusions	57	4.13e-02	1.48e-01	0.20500	0.179000	1.01e-01	1.98e-02	1.87e-01
Cell-Cycle	519	4.15e-02	1.48e-01	0.08630	0.064500	5.73e-02	1.24e-02	2.64e-02
Activation-of-APC/C-and-APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	69	4.15e-02	1.48e-01	0.14400	-0.136000	-4.52e-02	5.05e-02	5.16e-01
NCAM-signaling-for-neurite-out-growth	50	4.15e-02	1.48e-01	0.26900	0.174000	2.06e-01	3.39e-02	1.18e-02
Antigen-processing:-Ubiquitination-&-Proteasome-degradation	274	4.18e-02	1.48e-01	0.11600	-0.074600	-8.86e-02	3.41e-02	1.19e-02
Diseases-associated-with-N-glycosylation-of-proteins	16	4.19e-02	1.48e-01	0.16400	0.144000	-7.99e-02	3.20e-01	5.80e-01
Golgi-Cisternae-Pericentriolar-Stack-Reorganization	13	4.24e-02	1.50e-01	0.20200	0.197000	-4.70e-02	2.20e-01	7.69e-01
Disorders-of-transmembrane-transporters	131	4.34e-02	1.52e-01	0.16200	-0.127000	-1.00e-01	1.23e-02	4.79e-02
Regulation-of-expression-of-SLITs-and-ROBOs	125	4.35e-02	1.52e-01	0.17200	-0.129000	-1.15e-01	1.32e-02	2.68e-02
Signaling-by-GPCR	418	4.36e-02	1.52e-01	0.09580	0.065000	7.04e-02	2.32e-02	1.40e-02
Translation-initiation-complex-formation	46	4.36e-02	1.52e-01	0.17300	-0.053200	-1.64e-01	5.32e-01	5.39e-02
Recycling-pathway-of-L1	25	4.37e-02	1.52e-01	0.26400	0.242000	1.04e-01	3.60e-02	3.70e-01
RUNX2-regulates-bone-development	27	4.40e-02	1.53e-01	0.36300	0.277000	2.34e-01	1.26e-02	3.51e-02
Biotin-transport-and-metabolism	11	4.41e-02	1.53e-01	0.53900	-0.322000	-4.32e-01	6.47e-02	1.30e-02
Effects-of-PIP2-hydrolysis	23	4.49e-02	1.54e-01	0.22800	-0.220000	-5.90e-02	6.73e-02	6.24e-01
Cell-Cell-communication	83	4.50e-02	1.54e-01	0.20900	0.138000	1.57e-01	3.01e-02	1.33e-02
Tight-junction-interactions	11	4.50e-02	1.54e-01	0.19000	0.146000	-1.21e-01	4.01e-01	4.87e-01
HIV-Infection	209	4.52e-02	1.54e-01	0.13500	-0.094100	-9.62e-02	1.92e-02	1.68e-02
Biological-oxidations	111	4.52e-02	1.54e-01	0.18300	-0.134000	-1.25e-01	1.49e-02	2.29e-02
Cyclin-A:Cdk2-associated-events-at-S-phase-entry	81	4.57e-02	1.56e-01	0.16900	-0.147000	-8.27e-02	2.21e-02	1.98e-01
Signaling-by-NTRK1-(TRKA)	73	4.63e-02	1.57e-01	0.09450	0.094300	-5.17e-03	1.64e-01	9.39e-01
VLDLR-internalisation-and-degradation	11	4.65e-02	1.57e-01	0.19400	0.098700	-1.66e-01	5.71e-01	3.39e-01
GPCR-ligand-binding	157	4.65e-02	1.57e-01	0.11400	0.102000	5.13e-02	2.81e-02	2.68e-01
Pyrimidine-salvage	10	4.71e-02	1.59e-01	0.42300	0.174000	3.85e-01	3.42e-01	3.50e-02
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex	41	4.83e-02	1.62e-01	0.15200	-0.025000	-1.50e-01	7.82e-01	9.71e-02
Cyclin-E-associated-events-during-G1/S-transition	79	4.84e-02	1.62e-01	0.17400	-0.150000	-8.77e-02	2.15e-02	1.78e-01
COPI-mediated-anterograde-transport	74	4.93e-02	1.65e-01	0.08200	0.079300	-2.08e-02	2.39e-01	7.58e-01
Signaling-by-Nuclear-Receptors	200	5.01e-02	1.67e-01	0.08940	-0.033600	-8.28e-02	4.14e-01	4.39e-02
Influenza-Life-Cycle	110	5.05e-02	1.68e-01	0.17500	-0.111000	-1.35e-01	4.37e-02	1.46e-02
Neurotransmitter-release-cycle	33	5.07e-02	1.69e-01	0.23000	0.094400	2.10e-01	3.48e-01	3.73e-02
Amine-ligand-binding-receptors	12	5.12e-02	1.70e-01	0.41800	-0.368000	-1.97e-01	2.72e-02	2.37e-01
The-NLRP3-inflammasome	14	5.13e-02	1.70e-01	0.49700	0.328000	3.74e-01	3.35e-02	1.55e-02
C-type-lectin-receptors-(CLRs)	114	5.20e-02	1.71e-01	0.14800	-0.125000	-7.76e-02	2.08e-02	1.53e-01
Signaling-by-Interleukins	331	5.30e-02	1.74e-01	0.10300	0.077400	6.73e-02	1.59e-02	3.60e-02
Regulation-of-APC/C-activators-between-G1/S-and-early-anaphase	73	5.38e-02	1.77e-01	0.15400	-0.140000	-6.38e-02	3.86e-02	3.47e-01
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S	47	5.43e-02	1.77e-01	0.17400	-0.060200	-1.63e-01	4.75e-01	5.35e-02
SRP-dependent-cotranslational-protein-targeting-to-membrane	80	5.43e-02	1.77e-01	0.09780	-0.007340	-9.75e-02	9.10e-01	1.32e-01
TRAF6-mediated-IRF7-activation	14	5.50e-02	1.79e-01	0.17800	-0.058900	1.68e-01	7.03e-01	2.77e-01
Receptor-type-tyrosine-protein-phosphatases	15	5.56e-02	1.81e-01	0.43600	0.354000	2.54e-01	1.76e-02	8.89e-02
Resolution-of-D-loop-Structures-through-Holliday-Junction-Intermediates	30	5.58e-02	1.81e-01	0.30500	0.176000	2.50e-01	9.54e-02	1.80e-02
Oncogenic-MAPK-signaling	64	5.60e-02	1.81e-01	0.18600	0.161000	9.32e-02	2.56e-02	1.98e-01
Energy-dependent-regulation-of-mTOR-by-LKB1-AMPK	29	5.68e-02	1.83e-01	0.31900	-0.191000	-2.56e-01	7.52e-02	1.73e-02
Cell-Cycle,-Mitotic	436	5.69e-02	1.83e-01	0.08960	0.066200	6.03e-02	1.83e-02	3.16e-02
p75-NTR-receptor-mediated-signalling	90	5.70e-02	1.83e-01	0.19000	0.122000	1.46e-01	4.64e-02	1.68e-02
Regulation-of-PLK1-Activity-at-G2/M-Transition	86	5.72e-02	1.83e-01	0.13500	0.124000	5.19e-02	4.67e-02	4.06e-01
Metabolism-of-fat-soluble-vitamins	33	5.83e-02	1.84e-01	0.31200	0.240000	1.99e-01	1.72e-02	4.77e-02
HIV-Transcription-Initiation	45	5.87e-02	1.84e-01	0.26700	-0.170000	-2.05e-01	4.84e-02	1.73e-02
RNA-Polymerase-II-HIV-Promoter-Escape	45	5.87e-02	1.84e-01	0.26700	-0.170000	-2.05e-01	4.84e-02	1.73e-02
RNA-Polymerase-II-Promoter-Escape	45	5.87e-02	1.84e-01	0.26700	-0.170000	-2.05e-01	4.84e-02	1.73e-02
RNA-Polymerase-II-Transcription-Initiation	45	5.87e-02	1.84e-01	0.26700	-0.170000	-2.05e-01	4.84e-02	1.73e-02
RNA-Polymerase-II-Transcription-Initiation-And-Promoter-Clearance	45	5.87e-02	1.84e-01	0.26700	-0.170000	-2.05e-01	4.84e-02	1.73e-02
RNA-Polymerase-II-Transcription-Pre-Initiation-And-Promoter-Opening	45	5.87e-02	1.84e-01	0.26700	-0.170000	-2.05e-01	4.84e-02	1.73e-02
HSF1-activation	23	5.89e-02	1.85e-01	0.29600	-0.261000	-1.41e-01	3.05e-02	2.42e-01
Diseases-associated-with-the-TLR-signaling-cascade	22	6.01e-02	1.87e-01	0.38800	0.259000	2.89e-01	3.53e-02	1.90e-02
Diseases-of-Immune-System	22	6.01e-02	1.87e-01	0.38800	0.259000	2.89e-01	3.53e-02	1.90e-02
Negative-regulation-of-TCF-dependent-signaling-by-WNT-ligand-antagonists	10	6.05e-02	1.88e-01	0.57100	0.430000	3.76e-01	1.85e-02	3.96e-02
TCR-signaling	94	6.13e-02	1.90e-01	0.11700	-0.110000	-3.76e-02	6.49e-02	5.29e-01
AURKA-Activation-by-TPX2	71	6.19e-02	1.92e-01	0.16100	0.144000	7.26e-02	3.63e-02	2.91e-01
Resolution-of-D-Loop-Structures	31	6.30e-02	1.94e-01	0.30500	0.184000	2.43e-01	7.70e-02	1.92e-02
Regulation-of-TLR-by-endogenous-ligand	12	6.30e-02	1.94e-01	0.30900	0.088600	2.96e-01	5.95e-01	7.61e-02
NRAGE-signals-death-through-JNK	55	6.32e-02	1.94e-01	0.21600	0.121000	1.79e-01	1.22e-01	2.20e-02
Cargo-recognition-for-clathrin-mediated-endocytosis	85	6.34e-02	1.94e-01	0.10100	0.099400	1.65e-02	1.14e-01	7.93e-01
Ribosomal-scanning-and-start-codon-recognition	47	6.35e-02	1.94e-01	0.15400	-0.042900	-1.48e-01	6.11e-01	7.90e-02
Transcriptional-Regulation-by-MECP2	46	6.42e-02	1.95e-01	0.19600	-0.086900	-1.76e-01	3.08e-01	3.90e-02
Retinoid-metabolism-and-transport	29	6.43e-02	1.95e-01	0.33800	0.239000	2.39e-01	2.60e-02	2.57e-02
Activation-of-ATR-in-response-to-replication-stress	36	6.44e-02	1.95e-01	0.15800	0.030100	1.56e-01	7.55e-01	1.06e-01
MicroRNA-(miRNA)-biogenesis	23	6.45e-02	1.95e-01	0.36500	-0.282000	-2.32e-01	1.92e-02	5.44e-02
Glycogen-breakdown-(glycogenolysis)	14	6.48e-02	1.95e-01	0.48400	-0.352000	-3.32e-01	2.24e-02	3.17e-02
Signaling-by-NODAL	11	6.48e-02	1.95e-01	0.28600	-0.054200	-2.81e-01	7.56e-01	1.07e-01
Long-term-potentiation	16	6.49e-02	1.95e-01	0.22700	0.224000	3.34e-02	1.21e-01	8.17e-01
Amplification--of-signal-from-unattached--kinetochores-via-a-MAD2--inhibitory-signal	83	6.61e-02	1.98e-01	0.19000	0.148000	1.19e-01	1.98e-02	6.06e-02
Amplification-of-signal-from-the-kinetochores	83	6.61e-02	1.98e-01	0.19000	0.148000	1.19e-01	1.98e-02	6.06e-02
HATs-acetylate-histones	76	6.68e-02	2.00e-01	0.16000	-0.075900	-1.40e-01	2.53e-01	3.45e-02
p75NTR-signals-via-NF-kB	16	6.76e-02	2.02e-01	0.44200	0.290000	3.33e-01	4.43e-02	2.10e-02
Resolution-of-D-loop-Structures-through-Synthesis-Dependent-Strand-Annealing-(SDSA)	25	6.78e-02	2.02e-01	0.30300	0.161000	2.56e-01	1.64e-01	2.67e-02
Phosphorylation-of-the-APC/C	18	6.87e-02	2.04e-01	0.27100	0.254000	9.61e-02	6.22e-02	4.80e-01
Receptor-Mediated-Mitophagy	11	6.92e-02	2.04e-01	0.51900	-0.328000	-4.02e-01	5.94e-02	2.08e-02
Amino-acids-regulate-mTORC1	48	6.92e-02	2.04e-01	0.25300	-0.165000	-1.92e-01	4.87e-02	2.12e-02
Caspase-mediated-cleavage-of-cytoskeletal-proteins	12	6.93e-02	2.04e-01	0.50100	0.385000	3.22e-01	2.10e-02	5.38e-02
Metabolism-of-nucleotides	83	6.94e-02	2.04e-01	0.18300	-0.146000	-1.09e-01	2.16e-02	8.49e-02
RHO-GTPases-Activate-WASPs-and-WAVEs	36	6.99e-02	2.05e-01	0.29600	0.219000	1.99e-01	2.29e-02	3.90e-02
G-protein-activation	16	7.03e-02	2.06e-01	0.37000	0.316000	1.94e-01	2.89e-02	1.80e-01
Elevation-of-cytosolic-Ca2+-levels	11	7.10e-02	2.07e-01	0.40500	0.187000	3.59e-01	2.84e-01	3.92e-02
Cargo-concentration-in-the-ER	26	7.20e-02	2.10e-01	0.12800	0.123000	-3.47e-02	2.78e-01	7.59e-01
Transmission-across-Chemical-Synapses	164	7.22e-02	2.10e-01	0.13900	0.102000	9.53e-02	2.51e-02	3.56e-02
Regulation-of-HSF1-mediated-heat-shock-response	76	7.47e-02	2.16e-01	0.19900	-0.150000	-1.31e-01	2.34e-02	4.88e-02
Loss-of-function-of-MECP2-in-Rett-syndrome	12	7.47e-02	2.16e-01	0.30100	-0.088300	-2.88e-01	5.96e-01	8.39e-02
Pervasive-developmental-disorders	12	7.47e-02	2.16e-01	0.30100	-0.088300	-2.88e-01	5.96e-01	8.39e-02
MAP2K-and-MAPK-activation	35	7.62e-02	2.19e-01	0.29800	0.212000	2.10e-01	3.02e-02	3.16e-02
Influenza-Viral-RNA-Transcription-and-Replication	102	7.67e-02	2.21e-01	0.17200	-0.113000	-1.29e-01	4.85e-02	2.43e-02
Diseases-associated-with-glycosylation-precursor-biosynthesis	18	7.77e-02	2.23e-01	0.16300	0.023800	-1.61e-01	8.61e-01	2.38e-01
Visual-phototransduction	54	7.82e-02	2.24e-01	0.22300	0.136000	1.77e-01	8.44e-02	2.43e-02
EPH-ephrin-mediated-repulsion-of-cells	42	7.83e-02	2.24e-01	0.15600	0.150000	4.32e-02	9.18e-02	6.28e-01
Establishment-of-Sister-Chromatid-Cohesion	10	7.85e-02	2.24e-01	0.19100	0.175000	-7.72e-02	3.38e-01	6.73e-01
Sema4D-induced-cell-migration-and-growth-cone-collapse	19	7.95e-02	2.26e-01	0.34000	0.183000	2.86e-01	1.67e-01	3.07e-02
Keratinization	22	8.05e-02	2.28e-01	0.24600	0.228000	9.30e-02	6.40e-02	4.50e-01
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression	78	8.15e-02	2.30e-01	0.14200	-0.061500	-1.28e-01	3.48e-01	5.08e-02
Iron-uptake-and-transport	49	8.15e-02	2.30e-01	0.12000	-0.013100	-1.19e-01	8.74e-01	1.50e-01
Class-B/2-(Secretin-family-receptors)	46	8.16e-02	2.30e-01	0.22400	0.186000	1.25e-01	2.92e-02	1.42e-01
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit	80	8.19e-02	2.30e-01	0.13700	-0.057400	-1.24e-01	3.76e-01	5.45e-02
Synthesis-of-PIPs-at-the-Golgi-membrane	15	8.19e-02	2.30e-01	0.14900	0.080200	-1.25e-01	5.91e-01	4.02e-01
PIWI-interacting-RNA-(piRNA)-biogenesis	16	8.26e-02	2.31e-01	0.26800	-0.253000	-8.77e-02	7.96e-02	5.44e-01
NOTCH2-intracellular-domain-regulates-transcription	10	8.33e-02	2.32e-01	0.50700	0.305000	4.05e-01	9.46e-02	2.65e-02
MET-activates-RAP1-and-RAC1	11	8.34e-02	2.32e-01	0.34000	0.316000	1.24e-01	6.94e-02	4.76e-01
Budding-and-maturation-of-HIV-virion	25	8.35e-02	2.32e-01	0.16700	0.166000	1.91e-02	1.51e-01	8.69e-01
Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation	14	8.36e-02	2.32e-01	0.15300	-0.128000	8.41e-02	4.08e-01	5.86e-01
Deadenylation-dependent-mRNA-decay	50	8.39e-02	2.32e-01	0.24400	-0.166000	-1.78e-01	4.23e-02	2.93e-02
SUMOylation-of-chromatin-organization-proteins	55	8.39e-02	2.32e-01	0.10500	-0.003940	-1.05e-01	9.60e-01	1.78e-01
Ion-homeostasis	39	8.51e-02	2.34e-01	0.24100	-0.200000	-1.34e-01	3.07e-02	1.47e-01
JNK-(c-Jun-kinases)-phosphorylation-and--activation-mediated-by-activated-human-TAK1	17	8.52e-02	2.34e-01	0.41800	-0.300000	-2.91e-01	3.21e-02	3.81e-02
RHO-GTPases-activate-PAKs	20	8.52e-02	2.34e-01	0.29300	0.137000	2.59e-01	2.88e-01	4.52e-02
Nuclear-Receptor-transcription-pathway	43	8.62e-02	2.35e-01	0.25700	-0.167000	-1.94e-01	5.76e-02	2.74e-02
Axon-guidance	432	8.63e-02	2.35e-01	0.07670	0.061900	4.54e-02	2.82e-02	1.08e-01
Signaling-by-Non-Receptor-Tyrosine-Kinases	52	8.64e-02	2.35e-01	0.17400	0.156000	7.72e-02	5.14e-02	3.36e-01
Signaling-by-PTK6	52	8.64e-02	2.35e-01	0.17400	0.156000	7.72e-02	5.14e-02	3.36e-01
Death-Receptor-Signalling	129	8.68e-02	2.36e-01	0.14900	0.097100	1.12e-01	5.71e-02	2.77e-02
Circadian-Clock	66	8.73e-02	2.37e-01	0.12000	-0.031300	-1.16e-01	6.60e-01	1.04e-01
Disassembly-of-the-destruction-complex-and-recruitment-of-AXIN-to-the-membrane	27	8.77e-02	2.37e-01	0.12200	0.119000	-2.99e-02	2.86e-01	7.88e-01
Interleukin-1-family-signaling	114	8.79e-02	2.37e-01	0.06430	-0.063800	7.72e-03	2.40e-01	8.87e-01
ERK/MAPK-targets	21	8.82e-02	2.37e-01	0.16900	-0.006700	-1.68e-01	9.58e-01	1.82e-01
SUMOylation-of-intracellular-receptors	27	8.86e-02	2.38e-01	0.27400	-0.144000	-2.33e-01	1.94e-01	3.62e-02
Formation-of-tubulin-folding-intermediates-by-CCT/TriC	20	8.88e-02	2.38e-01	0.17500	0.009930	1.75e-01	9.39e-01	1.76e-01
Abortive-elongation-of-HIV-1-transcript-in-the-absence-of-Tat	23	8.90e-02	2.38e-01	0.19100	-0.187000	-4.06e-02	1.22e-01	7.36e-01
Glucagon-type-ligand-receptors	15	8.96e-02	2.39e-01	0.24500	0.238000	6.05e-02	1.11e-01	6.85e-01
rRNA-processing	178	9.01e-02	2.39e-01	0.12800	-0.089400	-9.21e-02	3.99e-02	3.44e-02
Cap-dependent-Translation-Initiation	86	9.02e-02	2.39e-01	0.14800	-0.074200	-1.28e-01	2.35e-01	4.10e-02
Eukaryotic-Translation-Initiation	86	9.02e-02	2.39e-01	0.14800	-0.074200	-1.28e-01	2.35e-01	4.10e-02
cGMP-effects	12	9.11e-02	2.41e-01	0.40000	0.205000	3.43e-01	2.19e-01	3.96e-02
Neurotransmitter-receptors-and-postsynaptic-signal-transmission	119	9.17e-02	2.42e-01	0.10300	0.095300	3.81e-02	7.30e-02	4.73e-01
Acyl-chain-remodelling-of-PC	18	9.31e-02	2.44e-01	0.34500	-0.288000	-1.90e-01	3.47e-02	1.63e-01
Loss-of-Nlp-from-mitotic-centrosomes	68	9.32e-02	2.44e-01	0.13400	0.125000	4.92e-02	7.55e-02	4.84e-01
Loss-of-proteins-required-for-interphase-microtubule-organization-from-the-centrosome	68	9.32e-02	2.44e-01	0.13400	0.125000	4.92e-02	7.55e-02	4.84e-01
Processing-of-Intronless-Pre-mRNAs	18	9.33e-02	2.44e-01	0.39900	-0.286000	-2.77e-01	3.54e-02	4.19e-02
Processing-of-Capped-Intronless-Pre-mRNA	26	9.33e-02	2.44e-01	0.31400	-0.194000	-2.47e-01	8.67e-02	2.95e-02
Nuclear-Events-(kinase-and-transcription-factor-activation)	24	9.35e-02	2.44e-01	0.18600	-0.040700	-1.82e-01	7.30e-01	1.23e-01
RUNX2-regulates-osteoblast-differentiation	21	9.40e-02	2.45e-01	0.33500	0.271000	1.97e-01	3.14e-02	1.19e-01
Transport-of-Mature-mRNA-Derived-from-an-Intronless-Transcript	40	9.46e-02	2.46e-01	0.25500	-0.160000	-1.98e-01	8.10e-02	2.99e-02
CREB1-phosphorylation-through-NMDA-receptor-mediated-activation-of-RAS-signaling	21	9.58e-02	2.48e-01	0.12600	0.115000	-5.26e-02	3.63e-01	6.77e-01
Conversion-from-APC/C:Cdc20-to-APC/C:Cdh1-in-late-anaphase	18	9.60e-02	2.48e-01	0.16400	0.163000	-1.18e-02	2.31e-01	9.31e-01
Downstream-signaling-of-activated-FGFR4	19	9.61e-02	2.48e-01	0.27500	-0.118000	-2.49e-01	3.74e-01	6.05e-02
Cooperation-of-Prefoldin-and-TriC/CCT--in-actin-and-tubulin-folding	26	9.70e-02	2.50e-01	0.10700	-0.081600	6.93e-02	4.71e-01	5.41e-01
Neutrophil-degranulation	356	9.72e-02	2.50e-01	0.07990	0.065600	4.56e-02	3.41e-02	1.41e-01
Fc-epsilon-receptor-(FCERI)-signaling	121	9.77e-02	2.51e-01	0.13600	-0.112000	-7.74e-02	3.44e-02	1.42e-01
Infectious-disease	362	9.88e-02	2.53e-01	0.06640	-0.030400	-5.91e-02	3.22e-01	5.46e-02
GPCR-downstream-signalling	380	9.94e-02	2.54e-01	0.07430	0.040500	6.22e-02	1.77e-01	3.80e-02
Transport-of-Mature-mRNAs-Derived-from-Intronless-Transcripts	41	1.00e-01	2.56e-01	0.25000	-0.157000	-1.94e-01	8.14e-02	3.19e-02
Carboxyterminal-post-translational-modifications-of-tubulin	26	1.02e-01	2.59e-01	0.23900	0.106000	2.14e-01	3.49e-01	5.93e-02
Activated-NTRK2-signals-through-FRS2-and-FRS3	10	1.04e-01	2.64e-01	0.32100	-0.103000	-3.04e-01	5.72e-01	9.64e-02
Recruitment-of-NuMA-to-mitotic-centrosomes	78	1.04e-01	2.64e-01	0.11200	0.107000	3.38e-02	1.03e-01	6.06e-01
Transcriptional-regulation-by-RUNX2	109	1.04e-01	2.64e-01	0.05970	-0.013000	5.83e-02	8.15e-01	2.94e-01
Post-chaperonin-tubulin-folding-pathway	18	1.05e-01	2.65e-01	0.38500	0.259000	2.85e-01	5.69e-02	3.62e-02
Mitotic-Prophase	80	1.05e-01	2.65e-01	0.06340	0.026600	-5.76e-02	6.82e-01	3.73e-01
Gene-Silencing-by-RNA	63	1.05e-01	2.65e-01	0.20600	-0.152000	-1.39e-01	3.66e-02	5.65e-02
Processive-synthesis-on-the-lagging-strand	14	1.07e-01	2.68e-01	0.19600	0.005410	1.96e-01	9.72e-01	2.04e-01
Nucleobase-biosynthesis	13	1.07e-01	2.68e-01	0.44800	-0.336000	-2.97e-01	3.58e-02	6.41e-02
TRAF6-mediated-NF-kB-activation	20	1.09e-01	2.72e-01	0.17800	0.021200	1.76e-01	8.70e-01	1.72e-01
Cytosolic-sensors-of-pathogen-associated-DNA	59	1.10e-01	2.74e-01	0.11700	0.027000	1.13e-01	7.20e-01	1.32e-01
Activation-of-HOX-genes-during-differentiation	51	1.10e-01	2.75e-01	0.21800	-0.136000	-1.70e-01	9.26e-02	3.58e-02
Activation-of-anterior-HOX-genes-in-hindbrain-development-during-early-embryogenesis	51	1.10e-01	2.75e-01	0.21800	-0.136000	-1.70e-01	9.26e-02	3.58e-02
Regulation-of-KIT-signaling	15	1.14e-01	2.83e-01	0.22600	0.050200	2.21e-01	7.37e-01	1.39e-01
Influenza-Infection	118	1.15e-01	2.85e-01	0.14300	-0.090800	-1.11e-01	8.89e-02	3.76e-02
Activation-of-RAC1	12	1.16e-01	2.87e-01	0.36300	0.317000	1.76e-01	5.70e-02	2.92e-01
Gene-and-protein-expression-by-JAK-STAT-signaling-after-Interleukin-12-stimulation	27	1.16e-01	2.87e-01	0.12900	0.129000	-8.29e-03	2.47e-01	9.41e-01
Transport-of-Mature-mRNA-derived-from-an-Intron-Containing-Transcript	70	1.17e-01	2.87e-01	0.19000	-0.126000	-1.42e-01	6.80e-02	3.99e-02
Centrosome-maturation	78	1.17e-01	2.87e-01	0.12600	0.115000	5.08e-02	7.93e-02	4.39e-01
Recruitment-of-mitotic-centrosome-proteins-and-complexes	78	1.17e-01	2.87e-01	0.12600	0.115000	5.08e-02	7.93e-02	4.39e-01
SLC-mediated-transmembrane-transport	150	1.18e-01	2.89e-01	0.10600	0.091400	5.33e-02	5.38e-02	2.61e-01
Interleukin-15-signaling	14	1.20e-01	2.94e-01	0.32300	-0.150000	-2.86e-01	3.30e-01	6.39e-02
Downstream-signaling-of-activated-FGFR2	21	1.21e-01	2.95e-01	0.20400	-0.058900	-1.96e-01	6.41e-01	1.20e-01
EGFR-downregulation	27	1.21e-01	2.96e-01	0.28700	0.228000	1.75e-01	4.05e-02	1.16e-01
Constitutive-Signaling-by-Aberrant-PI3K-in-Cancer	54	1.22e-01	2.96e-01	0.21600	0.158000	1.48e-01	4.47e-02	6.08e-02
mRNA-Capping	29	1.24e-01	3.00e-01	0.29400	-0.214000	-2.02e-01	4.64e-02	5.97e-02
Vitamin-B5-(pantothenate)-metabolism	15	1.27e-01	3.08e-01	0.40800	-0.288000	-2.88e-01	5.34e-02	5.33e-02
HDR-through-Homologous-Recombination-(HRR)-or-Single-Strand-Annealing-(SSA)	89	1.27e-01	3.08e-01	0.11800	0.049100	1.07e-01	4.24e-01	8.14e-02
Rab-regulation-of-trafficking	111	1.29e-01	3.10e-01	0.13300	-0.075200	-1.09e-01	1.72e-01	4.73e-02
Formation-of-TC-NER-Pre-Incision-Complex	53	1.30e-01	3.13e-01	0.21200	-0.140000	-1.59e-01	7.75e-02	4.48e-02
Negative-regulation-of-NMDA-receptor-mediated-neuronal-transmission	14	1.30e-01	3.13e-01	0.25600	0.243000	8.14e-02	1.16e-01	5.98e-01
Purine-ribonucleoside-monophosphate-biosynthesis	10	1.30e-01	3.13e-01	0.41100	-0.350000	-2.16e-01	5.52e-02	2.38e-01
APC/C-mediated-degradation-of-cell-cycle-proteins	79	1.31e-01	3.13e-01	0.11700	-0.108000	-4.44e-02	9.58e-02	4.95e-01
Regulation-of-mitotic-cell-cycle	79	1.31e-01	3.13e-01	0.11700	-0.108000	-4.44e-02	9.58e-02	4.95e-01
PI5P,-PP2A-and-IER3-Regulate-PI3K/AKT-Signaling	80	1.32e-01	3.15e-01	0.15300	0.127000	8.56e-02	4.99e-02	1.86e-01
Transcriptional-regulation-by-RUNX1	158	1.32e-01	3.15e-01	0.07770	-0.073300	-2.59e-02	1.12e-01	5.75e-01
Signaling-by-FGFR2-in-disease	34	1.33e-01	3.16e-01	0.26400	-0.176000	-1.97e-01	7.60e-02	4.67e-02
Homologous-DNA-Pairing-and-Strand-Exchange	41	1.33e-01	3.16e-01	0.15600	0.054700	1.46e-01	5.45e-01	1.07e-01
HCMV-Early-Events	57	1.34e-01	3.17e-01	0.06700	0.047200	-4.76e-02	5.38e-01	5.35e-01
Activation-of-the-AP-1-family-of-transcription-factors	10	1.35e-01	3.18e-01	0.34300	-0.142000	-3.13e-01	4.37e-01	8.70e-02
Interconversion-of-nucleotide-di--and-triphosphates	24	1.35e-01	3.18e-01	0.31700	-0.218000	-2.29e-01	6.41e-02	5.17e-02
Unfolded-Protein-Response-(UPR)	86	1.36e-01	3.21e-01	0.07010	0.070000	-3.89e-03	2.63e-01	9.50e-01
Signaling-by-ROBO-receptors	167	1.37e-01	3.22e-01	0.12000	-0.087000	-8.30e-02	5.28e-02	6.48e-02
GAB1-signalosome	15	1.37e-01	3.22e-01	0.31000	0.272000	1.49e-01	6.87e-02	3.18e-01
RHO-GTPases-activate-CIT	18	1.39e-01	3.26e-01	0.30500	0.162000	2.58e-01	2.34e-01	5.78e-02
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)	13	1.40e-01	3.27e-01	0.14700	0.059600	-1.35e-01	7.10e-01	4.00e-01
ADP-signalling-through-P2Y-purinoceptor-12	15	1.40e-01	3.27e-01	0.28200	0.256000	1.20e-01	8.66e-02	4.22e-01
MAP-kinase-activation	61	1.40e-01	3.27e-01	0.12700	-0.045500	-1.19e-01	5.39e-01	1.09e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE	72	1.40e-01	3.27e-01	0.16700	0.099800	1.34e-01	1.44e-01	4.90e-02
Downstream-signaling-of-activated-FGFR3	19	1.41e-01	3.28e-01	0.29500	-0.156000	-2.50e-01	2.39e-01	5.93e-02
Transcriptional-regulation-of-pluripotent-stem-cells	15	1.42e-01	3.28e-01	0.13200	0.067300	-1.14e-01	6.52e-01	4.45e-01
HSF1-dependent-transactivation	30	1.43e-01	3.30e-01	0.25900	-0.207000	-1.55e-01	4.96e-02	1.41e-01
G2/M-DNA-damage-checkpoint	56	1.43e-01	3.31e-01	0.12600	0.041300	1.19e-01	5.93e-01	1.22e-01
Synthesis-of-PIPs-at-the-late-endosome-membrane	11	1.44e-01	3.31e-01	0.25800	-0.064800	-2.50e-01	7.10e-01	1.51e-01
Signaling-by-FGFR3-in-disease	16	1.44e-01	3.31e-01	0.33500	-0.189000	-2.77e-01	1.92e-01	5.47e-02
Signaling-by-FGFR3-point-mutants-in-cancer	16	1.44e-01	3.31e-01	0.33500	-0.189000	-2.77e-01	1.92e-01	5.47e-02
GPVI-mediated-activation-cascade	29	1.45e-01	3.32e-01	0.26800	0.211000	1.65e-01	4.96e-02	1.24e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest	13	1.46e-01	3.33e-01	0.40600	0.314000	2.56e-01	4.96e-02	1.10e-01
PI-3K-cascade:FGFR4	12	1.46e-01	3.34e-01	0.36600	-0.192000	-3.11e-01	2.49e-01	6.22e-02
DDX58/IFIH1-mediated-induction-of-interferon-alpha/beta	58	1.47e-01	3.35e-01	0.15100	0.070300	1.34e-01	3.55e-01	7.81e-02
SUMOylation-of-RNA-binding-proteins	46	1.48e-01	3.35e-01	0.09230	0.007130	-9.20e-02	9.33e-01	2.81e-01
Attenuation-phase	21	1.48e-01	3.35e-01	0.25400	-0.224000	-1.20e-01	7.62e-02	3.41e-01
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	82	1.48e-01	3.35e-01	0.14300	-0.077700	-1.20e-01	2.24e-01	5.98e-02
Nonsense-Mediated-Decay-(NMD)	82	1.48e-01	3.35e-01	0.14300	-0.077700	-1.20e-01	2.24e-01	5.98e-02
Metabolism-of-folate-and-pterines	16	1.48e-01	3.35e-01	0.14000	0.035500	-1.35e-01	8.06e-01	3.48e-01
WNT5A-dependent-internalization-of-FZD4	15	1.48e-01	3.35e-01	0.23200	0.222000	6.89e-02	1.37e-01	6.44e-01
Regulation-of-IFNA-signaling	12	1.49e-01	3.35e-01	0.21800	0.031300	2.15e-01	8.51e-01	1.96e-01
TRP-channels	12	1.50e-01	3.37e-01	0.15700	-0.150000	4.78e-02	3.69e-01	7.74e-01
Vasopressin-regulates-renal-water-homeostasis-via-Aquaporins	31	1.52e-01	3.39e-01	0.11700	0.001110	-1.17e-01	9.91e-01	2.58e-01
Pre-NOTCH-Processing-in-Golgi	16	1.52e-01	3.39e-01	0.18400	-0.022600	-1.82e-01	8.75e-01	2.07e-01
Cardiac-conduction	95	1.52e-01	3.39e-01	0.13200	-0.111000	-7.14e-02	6.17e-02	2.29e-01
activated-TAK1-mediates-p38-MAPK-activation	18	1.52e-01	3.39e-01	0.34600	-0.264000	-2.23e-01	5.28e-02	1.01e-01
G-beta:gamma-signalling-through-CDC42	14	1.55e-01	3.44e-01	0.26800	0.247000	1.02e-01	1.09e-01	5.08e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE	27	1.55e-01	3.45e-01	0.28500	-0.213000	-1.90e-01	5.60e-02	8.76e-02
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE-during-HIV-infection	27	1.55e-01	3.45e-01	0.28500	-0.213000	-1.90e-01	5.60e-02	8.76e-02
Extra-nuclear-estrogen-signaling	62	1.56e-01	3.46e-01	0.15400	0.133000	7.83e-02	7.11e-02	2.87e-01
Metabolism-of-steroids	104	1.57e-01	3.47e-01	0.09290	-0.031900	-8.72e-02	5.74e-01	1.25e-01
trans-Golgi-Network-Vesicle-Budding	64	1.57e-01	3.47e-01	0.16400	0.136000	9.26e-02	6.03e-02	2.00e-01
HDR-through-Single-Strand-Annealing-(SSA)	36	1.57e-01	3.47e-01	0.13000	0.025000	1.28e-01	7.95e-01	1.84e-01
AKT-phosphorylates-targets-in-the-nucleus	10	1.58e-01	3.48e-01	0.46900	-0.320000	-3.44e-01	7.99e-02	5.99e-02
Gap-junction-trafficking-and-regulation	15	1.59e-01	3.49e-01	0.37700	0.285000	2.47e-01	5.62e-02	9.82e-02
Signal-amplification	23	1.60e-01	3.51e-01	0.21000	0.193000	8.21e-02	1.09e-01	4.95e-01
FRS-mediated-FGFR4-signaling	14	1.60e-01	3.51e-01	0.34300	-0.190000	-2.86e-01	2.19e-01	6.36e-02
Role-of-phospholipids-in-phagocytosis	24	1.61e-01	3.52e-01	0.29400	0.189000	2.25e-01	1.09e-01	5.63e-02
Mitotic-Telophase/Cytokinesis	13	1.62e-01	3.53e-01	0.20900	0.206000	3.40e-02	1.99e-01	8.32e-01
Interleukin-17-signaling	63	1.63e-01	3.56e-01	0.10500	-0.026700	-1.02e-01	7.14e-01	1.64e-01
Late-Phase-of-HIV-Life-Cycle	127	1.64e-01	3.56e-01	0.08010	-0.025400	-7.60e-02	6.22e-01	1.40e-01
Deadenylation-of-mRNA	20	1.64e-01	3.56e-01	0.30700	-0.186000	-2.45e-01	1.50e-01	5.82e-02
Nucleotide-Excision-Repair	109	1.64e-01	3.56e-01	0.14100	-0.103000	-9.68e-02	6.36e-02	8.12e-02
Prostacyclin-signalling-through-prostacyclin-receptor	13	1.66e-01	3.60e-01	0.27900	0.256000	1.12e-01	1.10e-01	4.85e-01
Cell-junction-organization	57	1.67e-01	3.60e-01	0.17500	0.143000	1.01e-01	6.23e-02	1.88e-01
TGF-beta-receptor-signaling-in-EMT-(epithelial-to-mesenchymal-transition)	15	1.67e-01	3.60e-01	0.27200	0.246000	1.17e-01	9.96e-02	4.31e-01
Unblocking-of-NMDA-receptors,-glutamate-binding-and-activation	13	1.68e-01	3.62e-01	0.23500	0.226000	6.51e-02	1.58e-01	6.84e-01
SUMOylation-of-DNA-methylation-proteins	16	1.68e-01	3.62e-01	0.23500	0.220000	8.30e-02	1.28e-01	5.66e-01
Selenoamino-acid-metabolism	76	1.69e-01	3.62e-01	0.16800	-0.115000	-1.22e-01	8.32e-02	6.57e-02
Role-of-LAT2/NTAL/LAB-on-calcium-mobilization	14	1.70e-01	3.63e-01	0.36400	0.221000	2.90e-01	1.53e-01	6.05e-02
Global-Genome-Nucleotide-Excision-Repair-(GG-NER)	83	1.71e-01	3.65e-01	0.15600	-0.099800	-1.19e-01	1.16e-01	6.02e-02
Acyl-chain-remodelling-of-PE	17	1.71e-01	3.66e-01	0.32800	-0.262000	-1.98e-01	6.15e-02	1.57e-01
Signaling-by-FGFR4-in-disease	10	1.72e-01	3.66e-01	0.28800	-0.096200	-2.71e-01	5.98e-01	1.38e-01
PI-3K-cascade:FGFR3	12	1.72e-01	3.66e-01	0.40200	-0.253000	-3.13e-01	1.29e-01	6.06e-02
ATF6-(ATF6-alpha)-activates-chaperone-genes	10	1.74e-01	3.69e-01	0.42300	-0.339000	-2.53e-01	6.31e-02	1.66e-01
Synthesis-of-PE	11	1.74e-01	3.69e-01	0.38400	-0.318000	-2.16e-01	6.81e-02	2.16e-01
RNA-Polymerase-I-Transcription-Termination	30	1.75e-01	3.69e-01	0.22100	-0.188000	-1.17e-01	7.53e-02	2.69e-01
FRS-mediated-FGFR3-signaling	14	1.75e-01	3.69e-01	0.37600	-0.241000	-2.88e-01	1.18e-01	6.21e-02
Pentose-phosphate-pathway	12	1.75e-01	3.69e-01	0.20100	0.200000	2.22e-02	2.30e-01	8.94e-01
Diseases-of-metabolism	70	1.75e-01	3.69e-01	0.17400	-0.122000	-1.23e-01	7.74e-02	7.42e-02
SHC1-events-in-EGFR-signaling	12	1.77e-01	3.72e-01	0.36500	0.303000	2.05e-01	6.96e-02	2.20e-01
Aquaporin-mediated-transport	34	1.77e-01	3.72e-01	0.14600	-0.042800	-1.40e-01	6.66e-01	1.58e-01
Gap-junction-trafficking	13	1.78e-01	3.72e-01	0.39600	0.294000	2.64e-01	6.62e-02	9.90e-02
Activation-of-IRF3/IRF7-mediated-by-TBK1/IKK-epsilon	15	1.78e-01	3.72e-01	0.33000	0.188000	2.72e-01	2.07e-01	6.86e-02
IRF3-mediated-induction-of-type-I-IFN	11	1.78e-01	3.72e-01	0.26900	0.088100	2.54e-01	6.13e-01	1.45e-01
Termination-of-translesion-DNA-synthesis	31	1.79e-01	3.72e-01	0.09070	-0.033300	8.44e-02	7.49e-01	4.16e-01
Paradoxical-activation-of-RAF-signaling-by-kinase-inactive-BRAF	39	1.81e-01	3.75e-01	0.21800	0.171000	1.36e-01	6.45e-02	1.43e-01
Signaling-by-RAS-mutants	39	1.81e-01	3.75e-01	0.21800	0.171000	1.36e-01	6.45e-02	1.43e-01
Signaling-by-moderate-kinase-activity-BRAF-mutants	39	1.81e-01	3.75e-01	0.21800	0.171000	1.36e-01	6.45e-02	1.43e-01
Signaling-downstream-of-RAS-mutants	39	1.81e-01	3.75e-01	0.21800	0.171000	1.36e-01	6.45e-02	1.43e-01
Oxidative-Stress-Induced-Senescence	62	1.81e-01	3.75e-01	0.09150	-0.013800	-9.04e-02	8.51e-01	2.18e-01
Signaling-by-NTRK2-(TRKB)	22	1.82e-01	3.77e-01	0.14100	-0.008870	-1.40e-01	9.43e-01	2.54e-01
Thrombin-signalling-through-proteinase-activated-receptors-(PARs)	22	1.85e-01	3.81e-01	0.20200	0.187000	7.70e-02	1.29e-01	5.32e-01
Transcriptional-regulation-of-white-adipocyte-differentiation	78	1.86e-01	3.81e-01	0.13600	-0.073100	-1.15e-01	2.65e-01	7.87e-02
Cohesin-Loading-onto-Chromatin	10	1.86e-01	3.81e-01	0.14600	0.098800	-1.08e-01	5.88e-01	5.55e-01
Formation-of-the-Early-Elongation-Complex	33	1.86e-01	3.81e-01	0.22500	-0.183000	-1.32e-01	6.97e-02	1.90e-01
Formation-of-the-HIV-1-Early-Elongation-Complex	33	1.86e-01	3.81e-01	0.22500	-0.183000	-1.32e-01	6.97e-02	1.90e-01
Regulation-of-FZD-by-ubiquitination	15	1.87e-01	3.83e-01	0.24200	-0.090100	-2.24e-01	5.46e-01	1.33e-01
Regulation-of-RUNX1-Expression-and-Activity	17	1.89e-01	3.87e-01	0.33400	0.216000	2.55e-01	1.23e-01	6.87e-02
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters	17	1.90e-01	3.89e-01	0.13500	0.134000	-1.89e-02	3.39e-01	8.93e-01
Pre-NOTCH-Expression-and-Processing	47	1.91e-01	3.89e-01	0.16100	0.141000	7.84e-02	9.48e-02	3.53e-01
Presynaptic-phase-of-homologous-DNA-pairing-and-strand-exchange	38	1.91e-01	3.89e-01	0.14700	0.052400	1.38e-01	5.76e-01	1.42e-01
Removal-of-the-Flap-Intermediate	13	1.91e-01	3.89e-01	0.15800	-0.016100	1.58e-01	9.20e-01	3.25e-01
Striated-Muscle-Contraction	27	1.92e-01	3.90e-01	0.18500	0.073400	1.70e-01	5.09e-01	1.27e-01
Translesion-synthesis-by-Y-family-DNA-polymerases-bypasses-lesions-on-DNA-template	37	1.93e-01	3.90e-01	0.09380	-0.009450	9.33e-02	9.21e-01	3.26e-01
NF-kB-is-activated-and-signals-survival	13	1.93e-01	3.90e-01	0.38100	0.247000	2.90e-01	1.23e-01	7.05e-02
Formation-of-a-pool-of-free-40S-subunits	70	1.94e-01	3.91e-01	0.10400	-0.033500	-9.80e-02	6.29e-01	1.57e-01
PI-3K-cascade:FGFR1	11	1.94e-01	3.91e-01	0.22300	-0.043400	-2.18e-01	8.03e-01	2.10e-01
Regulation-of-TP53-Activity-through-Phosphorylation	88	1.95e-01	3.91e-01	0.06740	0.002260	6.74e-02	9.71e-01	2.75e-01
RNA-Polymerase-I-Promoter-Escape	32	1.95e-01	3.91e-01	0.22800	-0.183000	-1.35e-01	7.27e-02	1.86e-01
APC/C:Cdc20-mediated-degradation-of-Cyclin-B	22	1.96e-01	3.93e-01	0.17400	0.167000	4.88e-02	1.76e-01	6.92e-01
Amino-acid-transport-across-the-plasma-membrane	21	1.96e-01	3.93e-01	0.30500	0.223000	2.08e-01	7.74e-02	9.95e-02
tRNA-processing-in-the-nucleus	56	1.97e-01	3.94e-01	0.18300	-0.118000	-1.39e-01	1.26e-01	7.22e-02
Synthesis,-secretion,-and-deacylation-of-Ghrelin	11	1.98e-01	3.95e-01	0.20000	0.199000	1.97e-02	2.52e-01	9.10e-01
Downstream-signaling-of-activated-FGFR1	20	1.98e-01	3.95e-01	0.12000	0.022200	-1.18e-01	8.64e-01	3.62e-01
Synthesis-of-glycosylphosphatidylinositol-(GPI)	17	1.99e-01	3.95e-01	0.33800	-0.245000	-2.32e-01	8.03e-02	9.74e-02
N-Glycan-antennae-elongation	13	1.99e-01	3.95e-01	0.22300	0.215000	6.13e-02	1.80e-01	7.02e-01
FOXO-mediated-transcription	54	2.01e-01	3.98e-01	0.12000	-0.041400	-1.13e-01	5.99e-01	1.52e-01
Eukaryotic-Translation-Elongation	61	2.01e-01	3.98e-01	0.16300	-0.096400	-1.32e-01	1.93e-01	7.57e-02
Signaling-by-WNT-in-cancer	28	2.03e-01	4.02e-01	0.08560	0.067400	-5.28e-02	5.37e-01	6.29e-01
Regulation-of-MECP2-expression-and-activity	28	2.05e-01	4.04e-01	0.19400	-0.087500	-1.73e-01	4.23e-01	1.14e-01
Metabolism-of-steroid-hormones	13	2.06e-01	4.05e-01	0.16300	0.163000	-5.00e-03	3.09e-01	9.75e-01
HIV-Life-Cycle	138	2.06e-01	4.06e-01	0.07850	-0.029900	-7.26e-02	5.45e-01	1.41e-01
Transcription-of-the-HIV-genome	66	2.08e-01	4.08e-01	0.16700	-0.110000	-1.26e-01	1.24e-01	7.78e-02
Synthesis-of-bile-acids-and-bile-salts-via-7alpha-hydroxycholesterol	12	2.08e-01	4.08e-01	0.36500	-0.216000	-2.93e-01	1.94e-01	7.86e-02
FGFR2-mutant-receptor-activation	24	2.08e-01	4.08e-01	0.26700	-0.209000	-1.66e-01	7.66e-02	1.59e-01
CRMPs-in-Sema3A-signaling	15	2.09e-01	4.08e-01	0.33600	0.208000	2.64e-01	1.62e-01	7.69e-02
Pre-NOTCH-Transcription-and-Translation	32	2.10e-01	4.11e-01	0.23600	0.180000	1.52e-01	7.80e-02	1.37e-01
Rap1-signalling	14	2.11e-01	4.11e-01	0.15600	0.004800	-1.56e-01	9.75e-01	3.13e-01
mRNA-decay-by-5'-to-3'-exoribonuclease	15	2.12e-01	4.12e-01	0.34100	-0.218000	-2.63e-01	1.44e-01	7.81e-02
Selenocysteine-synthesis	61	2.12e-01	4.13e-01	0.16600	-0.103000	-1.30e-01	1.63e-01	7.85e-02
B-WICH-complex-positively-regulates-rRNA-expression	32	2.14e-01	4.14e-01	0.08010	-0.067900	4.25e-02	5.07e-01	6.78e-01
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	63	2.15e-01	4.14e-01	0.15300	-0.088000	-1.26e-01	2.28e-01	8.47e-02
TBC/RABGAPs	42	2.15e-01	4.14e-01	0.09140	0.000542	-9.14e-02	9.95e-01	3.06e-01
Inactivation-of-APC/C-via-direct-inhibition-of-the-APC/C-complex	18	2.15e-01	4.14e-01	0.17100	0.168000	3.58e-02	2.18e-01	7.92e-01
Inhibition-of-the-proteolytic-activity-of-APC/C-required-for-the-onset-of-anaphase-by-mitotic-spindle-checkpoint-components	18	2.15e-01	4.14e-01	0.17100	0.168000	3.58e-02	2.18e-01	7.92e-01
SLBP-Dependent-Processing-of-Replication-Dependent-Histone-Pre-mRNAs	10	2.15e-01	4.14e-01	0.21800	-0.034900	-2.15e-01	8.48e-01	2.39e-01
Ephrin-signaling	19	2.15e-01	4.14e-01	0.13000	0.130000	-7.86e-03	3.27e-01	9.53e-01
p75NTR-recruits-signalling-complexes	13	2.17e-01	4.16e-01	0.37300	0.251000	2.76e-01	1.17e-01	8.46e-02
Class-I-MHC-mediated-antigen-processing-&-presentation	323	2.18e-01	4.18e-01	0.06950	-0.040900	-5.62e-02	2.08e-01	8.37e-02
Regulation-of-glycolysis-by-fructose-2,6-bisphosphate-metabolism	10	2.21e-01	4.21e-01	0.28500	-0.110000	-2.64e-01	5.48e-01	1.49e-01
HDR-through-Homologous-Recombination-(HRR)	63	2.21e-01	4.21e-01	0.13700	0.068800	1.18e-01	3.46e-01	1.05e-01
Ovarian-tumor-domain-proteases	36	2.22e-01	4.21e-01	0.14900	0.056100	1.38e-01	5.60e-01	1.52e-01
Josephin-domain-DUBs	10	2.22e-01	4.21e-01	0.40500	-0.317000	-2.53e-01	8.27e-02	1.66e-01
Cyclin-D-associated-events-in-G1	43	2.22e-01	4.21e-01	0.09720	0.096800	8.87e-03	2.73e-01	9.20e-01
G1-Phase	43	2.22e-01	4.21e-01	0.09720	0.096800	8.87e-03	2.73e-01	9.20e-01
Toll-Like-Receptor-3-(TLR3)-Cascade	87	2.23e-01	4.21e-01	0.04720	0.029600	-3.67e-02	6.34e-01	5.54e-01
Metabolism-of-non-coding-RNA	51	2.23e-01	4.21e-01	0.17900	-0.112000	-1.40e-01	1.68e-01	8.33e-02
snRNP-Assembly	51	2.23e-01	4.21e-01	0.17900	-0.112000	-1.40e-01	1.68e-01	8.33e-02
PI-3K-cascade:FGFR2	14	2.23e-01	4.21e-01	0.24100	-0.093400	-2.23e-01	5.45e-01	1.49e-01
FCGR-activation	11	2.24e-01	4.21e-01	0.40300	0.273000	2.96e-01	1.16e-01	8.93e-02
SLC-transporter-disorders	65	2.24e-01	4.21e-01	0.05470	0.032400	-4.41e-02	6.51e-01	5.39e-01
Glutathione-conjugation	25	2.24e-01	4.21e-01	0.24700	-0.199000	-1.47e-01	8.57e-02	2.04e-01
Processing-of-DNA-double-strand-break-ends	58	2.25e-01	4.23e-01	0.09430	0.019900	9.22e-02	7.93e-01	2.25e-01
Common-Pathway-of-Fibrin-Clot-Formation	10	2.26e-01	4.23e-01	0.26900	0.093400	2.52e-01	6.09e-01	1.67e-01
RAB-GEFs-exchange-GTP-for-GDP-on-RABs	81	2.26e-01	4.23e-01	0.12300	-0.064200	-1.05e-01	3.18e-01	1.02e-01
TNFR1-induced-proapoptotic-signaling	12	2.28e-01	4.26e-01	0.38000	0.285000	2.51e-01	8.79e-02	1.32e-01
Retrograde-neurotrophin-signalling	12	2.29e-01	4.27e-01	0.34500	0.282000	1.99e-01	9.07e-02	2.32e-01
Nucleotide-binding-domain,-leucine-rich-repeat-containing-receptor-(NLR)-signaling-pathways	45	2.29e-01	4.27e-01	0.19600	0.131000	1.47e-01	1.30e-01	8.89e-02
Signaling-by-FGFR4	33	2.30e-01	4.27e-01	0.14000	-0.043700	-1.33e-01	6.64e-01	1.85e-01
Formation-of-the-cornified-envelope	17	2.31e-01	4.30e-01	0.11500	0.109000	-3.72e-02	4.37e-01	7.90e-01
Signaling-by-Leptin	10	2.32e-01	4.31e-01	0.29200	-0.120000	-2.66e-01	5.11e-01	1.45e-01
Deregulated-CDK5-triggers-multiple-neurodegenerative-pathways-in-Alzheimer's-disease-models	18	2.34e-01	4.32e-01	0.16400	0.161000	3.16e-02	2.38e-01	8.17e-01
Neurodegenerative-Diseases	18	2.34e-01	4.32e-01	0.16400	0.161000	3.16e-02	2.38e-01	8.17e-01
RUNX1-regulates-genes-involved-in-megakaryocyte-differentiation-and-platelet-function	34	2.36e-01	4.35e-01	0.09540	-0.095300	4.40e-03	3.37e-01	9.65e-01
Deposition-of-new-CENPA-containing-nucleosomes-at-the-centromere	19	2.36e-01	4.35e-01	0.26600	0.220000	1.49e-01	9.73e-02	2.61e-01
Nucleosome-assembly	19	2.36e-01	4.35e-01	0.26600	0.220000	1.49e-01	9.73e-02	2.61e-01
TGF-beta-receptor-signaling-activates-SMADs	32	2.37e-01	4.36e-01	0.14500	0.137000	4.79e-02	1.81e-01	6.39e-01
FRS-mediated-FGFR1-signaling	13	2.38e-01	4.37e-01	0.21600	-0.063300	-2.06e-01	6.93e-01	1.98e-01
HIV-elongation-arrest-and-recovery	31	2.39e-01	4.37e-01	0.11900	-0.118000	-1.85e-02	2.58e-01	8.59e-01
Pausing-and-recovery-of-HIV-elongation	31	2.39e-01	4.37e-01	0.11900	-0.118000	-1.85e-02	2.58e-01	8.59e-01
MyD88-independent-TLR4-cascade	90	2.40e-01	4.38e-01	0.04890	0.045800	-1.71e-02	4.53e-01	7.79e-01
TRIF(TICAM1)-mediated-TLR4-signaling	90	2.40e-01	4.38e-01	0.04890	0.045800	-1.71e-02	4.53e-01	7.79e-01
CREB1-phosphorylation-through-the-activation-of-Adenylate-Cyclase	10	2.40e-01	4.38e-01	0.27200	-0.100000	-2.52e-01	5.84e-01	1.67e-01
Processive-synthesis-on-the-C-strand-of-the-telomere	10	2.41e-01	4.40e-01	0.14000	-0.123000	6.59e-02	5.00e-01	7.18e-01
Cytosolic-sulfonation-of-small-molecules	12	2.42e-01	4.40e-01	0.14700	0.145000	-2.40e-02	3.85e-01	8.85e-01
Olfactory-Signaling-Pathway	16	2.43e-01	4.41e-01	0.19200	0.055100	1.83e-01	7.03e-01	2.04e-01
Glucagon-signaling-in-metabolic-regulation	24	2.45e-01	4.43e-01	0.13900	0.136000	2.60e-02	2.48e-01	8.26e-01
Late-endosomal-microautophagy	28	2.45e-01	4.43e-01	0.15900	0.148000	5.72e-02	1.74e-01	6.00e-01
SUMOylation-of-SUMOylation-proteins	34	2.45e-01	4.43e-01	0.15800	-0.066700	-1.43e-01	5.01e-01	1.48e-01
FRS-mediated-FGFR2-signaling	16	2.45e-01	4.43e-01	0.23600	-0.103000	-2.12e-01	4.74e-01	1.42e-01
Endogenous-sterols	17	2.46e-01	4.44e-01	0.10400	0.085700	-5.88e-02	5.41e-01	6.75e-01
Class-A/1-(Rhodopsin-like-receptors)	108	2.46e-01	4.44e-01	0.07330	0.070300	2.09e-02	2.08e-01	7.08e-01
Signaling-by-FGFR2-IIIa-TM	19	2.48e-01	4.46e-01	0.28900	-0.221000	-1.87e-01	9.55e-02	1.59e-01
Phase-II---Conjugation-of-compounds	52	2.49e-01	4.46e-01	0.18000	-0.125000	-1.29e-01	1.19e-01	1.07e-01
Gastrin-CREB-signalling-pathway-via-PKC-and-MAPK	16	2.50e-01	4.48e-01	0.22800	0.207000	9.55e-02	1.52e-01	5.08e-01
VEGFA-VEGFR2-Pathway	90	2.53e-01	4.52e-01	0.13400	0.088900	1.00e-01	1.45e-01	1.00e-01
Signaling-by-Hedgehog	122	2.53e-01	4.52e-01	0.09390	0.047200	8.11e-02	3.68e-01	1.22e-01
RNA-Polymerase-I-Transcription-Initiation	46	2.53e-01	4.52e-01	0.19000	-0.135000	-1.34e-01	1.14e-01	1.15e-01
Insulin-processing	21	2.55e-01	4.56e-01	0.27700	0.184000	2.06e-01	1.44e-01	1.02e-01
Signaling-by-FGFR2	60	2.56e-01	4.56e-01	0.15100	-0.088500	-1.22e-01	2.36e-01	1.02e-01
Neurexins-and-neuroligins	38	2.58e-01	4.59e-01	0.18700	0.152000	1.08e-01	1.05e-01	2.48e-01
G-protein-mediated-events	46	2.59e-01	4.59e-01	0.13100	0.053500	1.19e-01	5.30e-01	1.61e-01
Lagging-Strand-Synthesis	19	2.60e-01	4.60e-01	0.15300	0.028600	1.50e-01	8.29e-01	2.58e-01
Zinc-transporters	12	2.63e-01	4.65e-01	0.28600	0.250000	1.39e-01	1.34e-01	4.05e-01
Viral-mRNA-Translation	58	2.63e-01	4.65e-01	0.15800	-0.097700	-1.24e-01	1.99e-01	1.02e-01
Metal-ion-SLC-transporters	20	2.67e-01	4.71e-01	0.11800	0.117000	-7.22e-03	3.64e-01	9.55e-01
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain	11	2.72e-01	4.80e-01	0.17300	0.009720	1.73e-01	9.55e-01	3.21e-01
Viral-Messenger-RNA-Synthesis	43	2.73e-01	4.80e-01	0.19000	-0.139000	-1.30e-01	1.15e-01	1.40e-01
LDL-clearance	16	2.73e-01	4.81e-01	0.17600	0.170000	4.44e-02	2.39e-01	7.58e-01
G-alpha-(i)-signalling-events	192	2.74e-01	4.81e-01	0.07230	0.036000	6.27e-02	3.90e-01	1.35e-01
Phase-I---Functionalization-of-compounds	54	2.75e-01	4.83e-01	0.15600	-0.126000	-9.27e-02	1.11e-01	2.39e-01
TCF-dependent-signaling-in-response-to-WNT	151	2.75e-01	4.83e-01	0.10200	-0.070900	-7.32e-02	1.33e-01	1.21e-01
Chk1/Chk2(Cds1)-mediated-inactivation-of-Cyclin-B:Cdk1-complex	12	2.76e-01	4.83e-01	0.35100	0.228000	2.67e-01	1.72e-01	1.10e-01
Transport-of-Ribonucleoproteins-into-the-Host-Nucleus	31	2.77e-01	4.83e-01	0.15900	-0.067700	-1.44e-01	5.14e-01	1.65e-01
Interleukin-6-signaling	10	2.78e-01	4.84e-01	0.17000	0.170000	-1.60e-03	3.51e-01	9.93e-01
Adherens-junctions-interactions	20	2.78e-01	4.84e-01	0.09050	0.058500	-6.90e-02	6.51e-01	5.93e-01
Sphingolipid-de-novo-biosynthesis	33	2.78e-01	4.84e-01	0.18600	0.155000	1.01e-01	1.22e-01	3.14e-01
Blood-group-systems-biosynthesis	11	2.78e-01	4.84e-01	0.22200	0.212000	6.57e-02	2.23e-01	7.06e-01
VEGFR2-mediated-vascular-permeability	25	2.79e-01	4.84e-01	0.24000	-0.185000	-1.54e-01	1.10e-01	1.83e-01
MAPK6/MAPK4-signaling	81	2.79e-01	4.84e-01	0.06790	-0.067300	-8.93e-03	2.95e-01	8.90e-01
ZBP1(DAI)-mediated-induction-of-type-I-IFNs	20	2.81e-01	4.86e-01	0.26700	0.206000	1.70e-01	1.11e-01	1.89e-01
Biosynthesis-of-DHA-derived-SPMs	11	2.81e-01	4.86e-01	0.36900	-0.247000	-2.74e-01	1.57e-01	1.15e-01
Transcriptional-regulation-by-small-RNAs	46	2.84e-01	4.91e-01	0.18100	-0.123000	-1.33e-01	1.49e-01	1.20e-01
Cell-surface-interactions-at-the-vascular-wall	88	2.85e-01	4.91e-01	0.13000	0.086900	9.68e-02	1.59e-01	1.17e-01
Transport-of-vitamins,-nucleosides,-and-related-molecules	29	2.86e-01	4.92e-01	0.12300	0.120000	2.63e-02	2.65e-01	8.06e-01
Cargo-trafficking-to-the-periciliary-membrane	46	2.86e-01	4.92e-01	0.17400	0.110000	1.35e-01	1.98e-01	1.14e-01
SHC1-events-in-ERBB2-signaling	21	2.91e-01	4.99e-01	0.21900	0.187000	1.14e-01	1.37e-01	3.65e-01
MyD88-cascade-initiated-on-plasma-membrane	77	2.92e-01	4.99e-01	0.07950	-0.021200	-7.66e-02	7.48e-01	2.45e-01
Toll-Like-Receptor-10-(TLR10)-Cascade	77	2.92e-01	4.99e-01	0.07950	-0.021200	-7.66e-02	7.48e-01	2.45e-01
Toll-Like-Receptor-5-(TLR5)-Cascade	77	2.92e-01	4.99e-01	0.07950	-0.021200	-7.66e-02	7.48e-01	2.45e-01
Regulation-of-TP53-Activity-through-Methylation	17	2.93e-01	5.00e-01	0.11100	-0.109000	2.41e-02	4.38e-01	8.64e-01
Plasma-lipoprotein-assembly,-remodeling,-and-clearance	52	2.93e-01	5.00e-01	0.09800	-0.027400	-9.41e-02	7.33e-01	2.41e-01
ADP-signalling-through-P2Y-purinoceptor-1	17	2.98e-01	5.06e-01	0.10500	0.100000	-3.25e-02	4.74e-01	8.17e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH3-(MutSbeta)	11	2.98e-01	5.06e-01	0.26300	-0.237000	-1.15e-01	1.74e-01	5.10e-01
APC-Cdc20-mediated-degradation-of-Nek2A	23	2.98e-01	5.06e-01	0.14000	0.136000	3.37e-02	2.61e-01	7.80e-01
GRB2-events-in-EGFR-signaling	11	3.00e-01	5.09e-01	0.31100	0.261000	1.70e-01	1.35e-01	3.30e-01
Golgi-Associated-Vesicle-Biogenesis	50	3.01e-01	5.09e-01	0.11900	0.109000	4.97e-02	1.84e-01	5.43e-01
M-Phase	299	3.01e-01	5.09e-01	0.03780	0.036900	8.21e-03	2.74e-01	8.08e-01
Telomere-C-strand-(Lagging-Strand)-Synthesis	23	3.02e-01	5.10e-01	0.15900	0.054800	1.49e-01	6.49e-01	2.16e-01
FGFR2-alternative-splicing	24	3.02e-01	5.10e-01	0.23400	-0.182000	-1.46e-01	1.22e-01	2.15e-01
Transcription-of-E2F-targets-under-negative-control-by-p107-(RBL1)-and-p130-(RBL2)-in-complex-with-HDAC1	15	3.04e-01	5.11e-01	0.19400	0.183000	6.56e-02	2.21e-01	6.60e-01
Hedgehog-'off'-state	93	3.04e-01	5.11e-01	0.04480	-0.042600	1.38e-02	4.78e-01	8.18e-01
Nuclear-Envelope-Breakdown	51	3.04e-01	5.11e-01	0.06970	0.069600	-4.56e-03	3.90e-01	9.55e-01
Homology-Directed-Repair	95	3.04e-01	5.11e-01	0.08000	0.029100	7.46e-02	6.24e-01	2.10e-01
ERCC6-(CSB)-and-EHMT2-(G9a)-positively-regulate-rRNA-expression	16	3.05e-01	5.12e-01	0.10400	0.040100	-9.60e-02	7.81e-01	5.06e-01
Formation-of-HIV-elongation-complex-in-the-absence-of-HIV-Tat	43	3.06e-01	5.12e-01	0.17500	-0.136000	-1.10e-01	1.24e-01	2.13e-01
TICAM1,TRAF6-dependent-induction-of-TAK1-complex	11	3.06e-01	5.12e-01	0.12200	0.054700	-1.10e-01	7.53e-01	5.29e-01
Transcriptional-Regulation-by-VENTX	34	3.07e-01	5.12e-01	0.11500	0.111000	2.90e-02	2.62e-01	7.70e-01
DNA-Damage-Recognition-in-GG-NER	38	3.07e-01	5.12e-01	0.17700	-0.143000	-1.05e-01	1.27e-01	2.62e-01
Synthesis-of-IP2,-IP,-and-Ins-in-the-cytosol	13	3.09e-01	5.14e-01	0.26100	0.227000	1.28e-01	1.57e-01	4.23e-01
RNA-polymerase-II-transcribes-snRNA-genes	70	3.09e-01	5.15e-01	0.13900	-0.091300	-1.05e-01	1.87e-01	1.27e-01
Nucleotide-like-(purinergic)-receptors	12	3.12e-01	5.18e-01	0.27900	-0.239000	-1.43e-01	1.51e-01	3.91e-01
Signaling-by-ERBB4	48	3.13e-01	5.18e-01	0.08830	0.086900	1.58e-02	2.98e-01	8.50e-01
RIP-mediated-NFkB-activation-via-ZBP1	17	3.13e-01	5.18e-01	0.28500	0.210000	1.93e-01	1.34e-01	1.69e-01
Synthesis-of-PC	24	3.13e-01	5.18e-01	0.23900	-0.178000	-1.60e-01	1.32e-01	1.75e-01
Ion-transport-by-P-type-ATPases	38	3.14e-01	5.19e-01	0.08360	-0.000184	8.36e-02	9.98e-01	3.73e-01
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell	40	3.14e-01	5.19e-01	0.18600	0.137000	1.26e-01	1.35e-01	1.69e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH6-(MutSalpha)	11	3.15e-01	5.19e-01	0.17300	-0.172000	-2.13e-02	3.23e-01	9.03e-01
TICAM1,-RIP1-mediated-IKK-complex-recruitment	18	3.15e-01	5.19e-01	0.10100	0.028300	-9.74e-02	8.35e-01	4.75e-01
HDMs-demethylate-histones	21	3.16e-01	5.19e-01	0.15100	-0.043800	-1.45e-01	7.28e-01	2.51e-01
Signaling-by-FGFR3	33	3.17e-01	5.20e-01	0.14900	-0.065700	-1.34e-01	5.14e-01	1.83e-01
Signaling-by-ERBB2-KD-Mutants	23	3.19e-01	5.22e-01	0.10300	0.103000	-4.67e-03	3.92e-01	9.69e-01
Signaling-by-ERBB2-in-Cancer	24	3.20e-01	5.22e-01	0.13100	0.127000	3.01e-02	2.80e-01	7.99e-01
RHO-GTPases-activate-PKNs	31	3.20e-01	5.22e-01	0.20600	0.135000	1.56e-01	1.94e-01	1.33e-01
Leading-Strand-Synthesis	13	3.20e-01	5.22e-01	0.25900	0.129000	2.24e-01	4.21e-01	1.61e-01
Polymerase-switching	13	3.20e-01	5.22e-01	0.25900	0.129000	2.24e-01	4.21e-01	1.61e-01
Polymerase-switching-on-the-C-strand-of-the-telomere	13	3.20e-01	5.22e-01	0.25900	0.129000	2.24e-01	4.21e-01	1.61e-01
Transcription-Coupled-Nucleotide-Excision-Repair-(TC-NER)	77	3.23e-01	5.25e-01	0.13300	-0.097400	-9.01e-02	1.40e-01	1.72e-01
Transport-of-the-SLBP-independent-Mature-mRNA	34	3.24e-01	5.27e-01	0.17400	-0.096800	-1.45e-01	3.29e-01	1.44e-01
Regulation-of-FOXO-transcriptional-activity-by-acetylation	10	3.26e-01	5.28e-01	0.35900	-0.234000	-2.73e-01	2.00e-01	1.36e-01
Post-translational-modification:-synthesis-of-GPI-anchored-proteins	59	3.26e-01	5.28e-01	0.14700	-0.094700	-1.13e-01	2.09e-01	1.35e-01
TP53-Regulates-Transcription-of-Caspase-Activators-and-Caspases	10	3.26e-01	5.28e-01	0.30900	0.262000	1.65e-01	1.52e-01	3.66e-01
Negative-regulation-of-MET-activity	19	3.27e-01	5.28e-01	0.24800	0.198000	1.50e-01	1.36e-01	2.59e-01
IKK-complex-recruitment-mediated-by-RIP1	20	3.27e-01	5.29e-01	0.12700	0.126000	1.58e-02	3.31e-01	9.03e-01
Arachidonic-acid-metabolism	36	3.28e-01	5.29e-01	0.07520	0.074200	-1.22e-02	4.41e-01	8.99e-01
Interactions-of-Vpr-with-host-cellular-proteins	33	3.30e-01	5.31e-01	0.16000	-0.079400	-1.39e-01	4.30e-01	1.68e-01
Toll-like-Receptor-Cascades	133	3.31e-01	5.31e-01	0.07170	0.064800	3.06e-02	1.97e-01	5.43e-01
Negative-regulators-of-DDX58/IFIH1-signaling	32	3.31e-01	5.31e-01	0.11300	0.027200	1.10e-01	7.90e-01	2.83e-01
ESR-mediated-signaling	142	3.31e-01	5.31e-01	0.03220	0.027100	-1.74e-02	5.77e-01	7.21e-01
Glycogen-storage-diseases	13	3.33e-01	5.31e-01	0.28300	-0.233000	-1.61e-01	1.46e-01	3.16e-01
alpha-linolenic-(omega3)-and-linoleic-(omega6)-acid-metabolism	10	3.33e-01	5.31e-01	0.35900	-0.238000	-2.69e-01	1.93e-01	1.41e-01
alpha-linolenic-acid-(ALA)-metabolism	10	3.33e-01	5.31e-01	0.35900	-0.238000	-2.69e-01	1.93e-01	1.41e-01
Interleukin-37-signaling	18	3.33e-01	5.31e-01	0.27200	0.190000	1.94e-01	1.62e-01	1.55e-01
LGI-ADAM-interactions	10	3.36e-01	5.35e-01	0.14800	0.013400	-1.47e-01	9.41e-01	4.20e-01
Negative-regulation-of-the-PI3K/AKT-network	87	3.36e-01	5.35e-01	0.11200	0.090800	6.58e-02	1.44e-01	2.89e-01
Trafficking-and-processing-of-endosomal-TLR	11	3.36e-01	5.35e-01	0.23000	0.213000	8.73e-02	2.22e-01	6.16e-01
Transport-of-the-SLBP-Dependant-Mature-mRNA	35	3.38e-01	5.36e-01	0.17000	-0.096000	-1.41e-01	3.26e-01	1.50e-01
Synthesis-of-bile-acids-and-bile-salts	22	3.38e-01	5.36e-01	0.21900	-0.127000	-1.79e-01	3.03e-01	1.46e-01
Interleukin-receptor-SHC-signaling	21	3.38e-01	5.36e-01	0.23900	0.186000	1.51e-01	1.41e-01	2.30e-01
PI3K-events-in-ERBB2-signaling	15	3.39e-01	5.36e-01	0.13100	0.131000	3.04e-03	3.79e-01	9.84e-01
DNA-Damage-Bypass	46	3.39e-01	5.36e-01	0.07530	0.002080	7.53e-02	9.81e-01	3.77e-01
Beta-catenin-phosphorylation-cascade	17	3.41e-01	5.38e-01	0.09640	0.089300	-3.63e-02	5.24e-01	7.96e-01
Binding-and-Uptake-of-Ligands-by-Scavenger-Receptors	32	3.42e-01	5.38e-01	0.07860	-0.012200	7.77e-02	9.05e-01	4.47e-01
DAP12-signaling	23	3.42e-01	5.38e-01	0.23400	0.175000	1.56e-01	1.47e-01	1.94e-01
Regulation-of-signaling-by-CBL	18	3.42e-01	5.38e-01	0.23700	0.134000	1.95e-01	3.23e-01	1.51e-01
Adenylate-cyclase-inhibitory-pathway	12	3.43e-01	5.38e-01	0.31300	0.196000	2.44e-01	2.39e-01	1.43e-01
Signaling-by-FGFR1	38	3.43e-01	5.38e-01	0.06670	0.063800	-1.97e-02	4.97e-01	8.34e-01
Eukaryotic-Translation-Termination	62	3.44e-01	5.39e-01	0.12900	-0.073700	-1.06e-01	3.16e-01	1.51e-01
Formation-of-Fibrin-Clot-(Clotting-Cascade)	18	3.45e-01	5.40e-01	0.19900	0.090700	1.77e-01	5.06e-01	1.93e-01
Alpha-protein-kinase-1-signaling-pathway	11	3.48e-01	5.44e-01	0.13600	0.135000	-1.61e-02	4.37e-01	9.27e-01
G0-and-Early-G1	25	3.50e-01	5.46e-01	0.16900	0.150000	7.77e-02	1.94e-01	5.02e-01
PLC-beta-mediated-events	45	3.51e-01	5.46e-01	0.10700	0.037100	1.00e-01	6.67e-01	2.46e-01
G-beta:gamma-signalling-through-BTK	12	3.51e-01	5.46e-01	0.13100	0.131000	-1.30e-02	4.33e-01	9.38e-01
RHO-GTPases-Activate-NADPH-Oxidases	19	3.51e-01	5.46e-01	0.08420	0.051800	-6.64e-02	6.96e-01	6.16e-01
rRNA-modification-in-the-nucleus-and-cytosol	54	3.51e-01	5.46e-01	0.08170	0.017200	7.99e-02	8.28e-01	3.10e-01
Metabolic-disorders-of-biological-oxidation-enzymes	17	3.51e-01	5.46e-01	0.08950	-0.051800	7.30e-02	7.12e-01	6.02e-01
RHO-GTPases-activate-KTN1	10	3.52e-01	5.46e-01	0.27800	0.243000	1.35e-01	1.84e-01	4.59e-01
Uptake-and-actions-of-bacterial-toxins	23	3.53e-01	5.47e-01	0.22600	0.144000	1.74e-01	2.30e-01	1.49e-01
Response-of-EIF2AK1-(HRI)-to-heme-deficiency	15	3.55e-01	5.49e-01	0.26500	0.157000	2.13e-01	2.91e-01	1.53e-01
PIP3-activates-AKT-signaling	237	3.56e-01	5.49e-01	0.06600	-0.038400	-5.36e-02	3.10e-01	1.56e-01
Notch-HLH-transcription-pathway	27	3.56e-01	5.49e-01	0.07480	0.069200	-2.85e-02	5.34e-01	7.98e-01
Nuclear-Pore-Complex-(NPC)-Disassembly	35	3.57e-01	5.51e-01	0.06140	0.047300	-3.92e-02	6.29e-01	6.88e-01
Constitutive-Signaling-by-EGFRvIII	14	3.59e-01	5.51e-01	0.16400	-0.039200	-1.59e-01	8.00e-01	3.02e-01
Signaling-by-EGFRvIII-in-Cancer	14	3.59e-01	5.51e-01	0.16400	-0.039200	-1.59e-01	8.00e-01	3.02e-01
Transcriptional-regulation-by-RUNX3	92	3.60e-01	5.53e-01	0.03930	-0.018100	3.49e-02	7.65e-01	5.64e-01
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides	67	3.61e-01	5.54e-01	0.13500	0.099200	9.12e-02	1.61e-01	1.97e-01
Signaling-by-NOTCH1	69	3.62e-01	5.54e-01	0.05000	0.048600	-1.14e-02	4.85e-01	8.70e-01
Activation-of-kainate-receptors-upon-glutamate-binding	22	3.66e-01	5.60e-01	0.11700	0.116000	1.71e-02	3.47e-01	8.90e-01
COPI-independent-Golgi-to-ER-retrograde-traffic	31	3.68e-01	5.62e-01	0.15800	0.136000	7.87e-02	1.89e-01	4.49e-01
TRAF6-mediated-induction-of-NFkB-and-MAP-kinases-upon-TLR7/8-or-9-activation	83	3.69e-01	5.64e-01	0.04890	0.004760	-4.87e-02	9.40e-01	4.44e-01
Signaling-by-Type-1-Insulin-like-Growth-Factor-1-Receptor-(IGF1R)	39	3.70e-01	5.64e-01	0.15000	0.126000	8.20e-02	1.73e-01	3.76e-01
Metabolism-of-Angiotensinogen-to-Angiotensins	11	3.70e-01	5.64e-01	0.30500	0.244000	1.82e-01	1.61e-01	2.96e-01
Peptide-chain-elongation	57	3.71e-01	5.64e-01	0.12300	-0.065700	-1.03e-01	3.91e-01	1.77e-01
Lysosome-Vesicle-Biogenesis	28	3.72e-01	5.64e-01	0.20600	0.140000	1.50e-01	1.99e-01	1.68e-01
Transcriptional-Regulation-by-E2F6	33	3.74e-01	5.67e-01	0.17700	0.141000	1.08e-01	1.62e-01	2.83e-01
Biosynthesis-of-specialized-proresolving-mediators-(SPMs)	13	3.74e-01	5.67e-01	0.28000	-0.169000	-2.24e-01	2.91e-01	1.63e-01
RNA-Polymerase-II-Pre-transcription-Events	77	3.75e-01	5.67e-01	0.12100	-0.077900	-9.23e-02	2.38e-01	1.62e-01
RMTs-methylate-histone-arginines	28	3.75e-01	5.67e-01	0.13600	-0.051100	-1.26e-01	6.40e-01	2.49e-01
G-alpha-(12/13)-signalling-events	70	3.78e-01	5.71e-01	0.10700	0.055400	9.12e-02	4.23e-01	1.87e-01
DAP12-interactions	25	3.80e-01	5.73e-01	0.21600	0.149000	1.56e-01	1.97e-01	1.77e-01
Thromboxane-signalling-through-TP-receptor	15	3.81e-01	5.73e-01	0.12800	0.128000	8.11e-03	3.91e-01	9.57e-01
Intracellular-signaling-by-second-messengers	272	3.81e-01	5.73e-01	0.06260	-0.038900	-4.91e-02	2.71e-01	1.65e-01
Pausing-and-recovery-of-Tat-mediated-HIV-elongation	29	3.82e-01	5.73e-01	0.08470	-0.084600	3.43e-03	4.30e-01	9.74e-01
Tat-mediated-HIV-elongation-arrest-and-recovery	29	3.82e-01	5.73e-01	0.08470	-0.084600	3.43e-03	4.30e-01	9.74e-01
SEMA3A-Plexin-repulsion-signaling-by-inhibiting-Integrin-adhesion	14	3.83e-01	5.74e-01	0.28300	0.187000	2.12e-01	2.26e-01	1.69e-01
G1/S-Specific-Transcription	27	3.83e-01	5.74e-01	0.20500	0.152000	1.38e-01	1.72e-01	2.15e-01
ISG15-antiviral-mechanism	67	3.90e-01	5.83e-01	0.13100	-0.092300	-9.24e-02	1.92e-01	1.91e-01
RNA-Polymerase-I-Promoter-Clearance	50	3.92e-01	5.84e-01	0.14800	-0.098600	-1.11e-01	2.28e-01	1.75e-01
RNA-Polymerase-I-Transcription	50	3.92e-01	5.84e-01	0.14800	-0.098600	-1.11e-01	2.28e-01	1.75e-01
Constitutive-Signaling-by-Ligand-Responsive-EGFR-Cancer-Variants	18	3.92e-01	5.84e-01	0.15900	-0.054600	-1.49e-01	6.88e-01	2.75e-01
Signaling-by-Ligand-Responsive-EGFR-Variants-in-Cancer	18	3.92e-01	5.84e-01	0.15900	-0.054600	-1.49e-01	6.88e-01	2.75e-01
Meiotic-synapsis	23	3.94e-01	5.85e-01	0.17400	0.152000	8.58e-02	2.08e-01	4.76e-01
RAF-activation	29	3.94e-01	5.85e-01	0.19300	-0.126000	-1.46e-01	2.40e-01	1.74e-01
WNT-ligand-biogenesis-and-trafficking	16	3.95e-01	5.86e-01	0.25200	0.157000	1.97e-01	2.77e-01	1.73e-01
Prefoldin-mediated-transfer-of-substrate--to-CCT/TriC	24	3.95e-01	5.86e-01	0.07040	-0.044600	5.45e-02	7.06e-01	6.44e-01
G-alpha-(s)-signalling-events	81	3.96e-01	5.86e-01	0.11800	0.081800	8.46e-02	2.04e-01	1.88e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-Cytochrome-C-Release	16	4.02e-01	5.93e-01	0.25200	0.195000	1.59e-01	1.77e-01	2.71e-01
Dopamine-Neurotransmitter-Release-Cycle	17	4.02e-01	5.93e-01	0.14600	0.040000	1.41e-01	7.75e-01	3.15e-01
ATF4-activates-genes-in-response-to-endoplasmic-reticulum--stress	24	4.03e-01	5.93e-01	0.06970	-0.053900	4.42e-02	6.48e-01	7.08e-01
Nuclear-import-of-Rev-protein	31	4.03e-01	5.93e-01	0.13800	-0.061500	-1.24e-01	5.54e-01	2.34e-01
Myogenesis	22	4.03e-01	5.94e-01	0.10900	0.109000	1.41e-02	3.78e-01	9.09e-01
TICAM1-dependent-activation-of-IRF3/IRF7	12	4.04e-01	5.94e-01	0.22900	0.107000	2.02e-01	5.22e-01	2.25e-01
MAPK-family-signaling-cascades	242	4.05e-01	5.94e-01	0.06560	0.042100	5.02e-02	2.61e-01	1.79e-01
Glycogen-synthesis	14	4.06e-01	5.94e-01	0.26100	-0.207000	-1.59e-01	1.80e-01	3.02e-01
Initiation-of-Nuclear-Envelope-Reformation	12	4.06e-01	5.94e-01	0.09890	0.080700	-5.72e-02	6.28e-01	7.32e-01
Nuclear-Envelope-Reassembly	12	4.06e-01	5.94e-01	0.09890	0.080700	-5.72e-02	6.28e-01	7.32e-01
ABC-transporters-in-lipid-homeostasis	14	4.07e-01	5.94e-01	0.27400	-0.181000	-2.06e-01	2.41e-01	1.83e-01
IRAK4-deficiency-(TLR2/4)	10	4.08e-01	5.96e-01	0.31900	0.205000	2.44e-01	2.62e-01	1.81e-01
MyD88-deficiency-(TLR2/4)	10	4.08e-01	5.96e-01	0.31900	0.205000	2.44e-01	2.62e-01	1.81e-01
Toll-Like-Receptor-9-(TLR9)-Cascade	88	4.09e-01	5.96e-01	0.03710	0.018600	-3.21e-02	7.64e-01	6.03e-01
Bile-acid-and-bile-salt-metabolism	25	4.11e-01	5.97e-01	0.20200	-0.131000	-1.54e-01	2.58e-01	1.83e-01
Methylation	12	4.12e-01	5.98e-01	0.29600	-0.219000	-1.98e-01	1.88e-01	2.35e-01
CD28-co-stimulation	32	4.12e-01	5.99e-01	0.14500	0.071500	1.26e-01	4.84e-01	2.18e-01
GRB2-events-in-ERBB2-signaling	15	4.14e-01	6.00e-01	0.17900	0.165000	6.92e-02	2.69e-01	6.43e-01
ERBB2-Regulates-Cell-Motility	14	4.14e-01	6.00e-01	0.18300	0.170000	6.97e-02	2.72e-01	6.52e-01
Downregulation-of-TGF-beta-receptor-signaling	26	4.18e-01	6.04e-01	0.11900	0.114000	3.49e-02	3.16e-01	7.58e-01
PI3K/AKT-Signaling-in-Cancer	81	4.18e-01	6.04e-01	0.09830	0.082200	5.40e-02	2.01e-01	4.01e-01
NR1H3-&-NR1H2-regulate-gene-expression-linked-to-cholesterol-transport-and-efflux	32	4.19e-01	6.05e-01	0.15000	-0.078900	-1.28e-01	4.40e-01	2.10e-01
Nucleotide-salvage	20	4.20e-01	6.06e-01	0.14500	0.050500	1.36e-01	6.96e-01	2.92e-01
Translesion-Synthesis-by-POLH	18	4.21e-01	6.06e-01	0.15200	-0.142000	-5.16e-02	2.95e-01	7.05e-01
PTK6-Regulates-RHO-GTPases,-RAS-GTPase-and-MAP-kinases	14	4.21e-01	6.06e-01	0.25800	0.203000	1.59e-01	1.89e-01	3.04e-01
Acyl-chain-remodelling-of-PG	10	4.21e-01	6.06e-01	0.23900	-0.213000	-1.08e-01	2.43e-01	5.55e-01
Signaling-by-NOTCH3	46	4.22e-01	6.06e-01	0.04900	0.031300	-3.78e-02	7.14e-01	6.58e-01
Cyclin-A/B1/B2-associated-events-during-G2/M-transition	23	4.22e-01	6.06e-01	0.20600	0.132000	1.58e-01	2.73e-01	1.90e-01
S-Phase	152	4.25e-01	6.08e-01	0.02750	-0.023400	1.45e-02	6.19e-01	7.58e-01
Assembly-Of-The-HIV-Virion	15	4.26e-01	6.09e-01	0.13700	0.135000	2.64e-02	3.67e-01	8.59e-01
RIPK1-mediated-regulated-necrosis	14	4.31e-01	6.15e-01	0.09870	0.095100	-2.65e-02	5.38e-01	8.64e-01
Regulated-Necrosis	14	4.31e-01	6.15e-01	0.09870	0.095100	-2.65e-02	5.38e-01	8.64e-01
NOTCH3-Intracellular-Domain-Regulates-Transcription	22	4.36e-01	6.22e-01	0.07990	0.077800	-1.82e-02	5.28e-01	8.82e-01
Synthesis-of-IP3-and-IP4-in-the-cytosol	22	4.38e-01	6.24e-01	0.07650	-0.023400	7.28e-02	8.49e-01	5.54e-01
Signaling-by-EGFR-in-Cancer	22	4.39e-01	6.25e-01	0.10700	0.105000	1.63e-02	3.92e-01	8.95e-01
Ras-activation-upon-Ca2+-influx-through-NMDA-receptor	14	4.40e-01	6.25e-01	0.09560	0.091000	-2.94e-02	5.56e-01	8.49e-01
SUMO-E3-ligases-SUMOylate-target-proteins	153	4.41e-01	6.26e-01	0.02830	0.026400	-1.02e-02	5.73e-01	8.28e-01
IL-6-type-cytokine-receptor-ligand-interactions	12	4.41e-01	6.26e-01	0.23600	0.123000	2.02e-01	4.60e-01	2.26e-01
Vpr-mediated-nuclear-import-of-PICs	31	4.43e-01	6.28e-01	0.10300	-0.028600	-9.91e-02	7.83e-01	3.40e-01
Growth-hormone-receptor-signaling	20	4.45e-01	6.30e-01	0.18600	-0.157000	-9.92e-02	2.24e-01	4.43e-01
RAF/MAP-kinase-cascade	202	4.46e-01	6.30e-01	0.03090	0.000450	3.09e-02	9.91e-01	4.50e-01
Signaling-by-VEGF	98	4.46e-01	6.30e-01	0.09750	0.063300	7.41e-02	2.79e-01	2.05e-01
Stimuli-sensing-channels	55	4.47e-01	6.30e-01	0.12800	-0.080400	-9.90e-02	3.02e-01	2.04e-01
SHC1-events-in-ERBB4-signaling	13	4.48e-01	6.31e-01	0.19300	0.175000	8.09e-02	2.75e-01	6.13e-01
PECAM1-interactions	11	4.50e-01	6.31e-01	0.22300	0.103000	1.97e-01	5.55e-01	2.57e-01
CDC6-association-with-the-ORC:origin-complex	11	4.51e-01	6.31e-01	0.16500	0.040800	1.60e-01	8.15e-01	3.59e-01
Formation-of-HIV-1-elongation-complex-containing-HIV-1-Tat	41	4.51e-01	6.31e-01	0.15000	-0.113000	-9.88e-02	2.09e-01	2.74e-01
HIV-Transcription-Elongation	41	4.51e-01	6.31e-01	0.15000	-0.113000	-9.88e-02	2.09e-01	2.74e-01
Tat-mediated-elongation-of-the-HIV-1-transcript	41	4.51e-01	6.31e-01	0.15000	-0.113000	-9.88e-02	2.09e-01	2.74e-01
Chaperonin-mediated-protein-folding	78	4.52e-01	6.32e-01	0.05900	0.012100	5.78e-02	8.53e-01	3.78e-01
Signaling-by-FGFR1-in-disease	32	4.52e-01	6.32e-01	0.07800	-0.002970	-7.79e-02	9.77e-01	4.46e-01
Reproduction	52	4.55e-01	6.34e-01	0.11800	0.097800	6.52e-02	2.23e-01	4.16e-01
RAF-independent-MAPK1/3-activation	21	4.55e-01	6.34e-01	0.19400	0.157000	1.15e-01	2.13e-01	3.63e-01
BBSome-mediated-cargo-targeting-to-cilium	21	4.56e-01	6.36e-01	0.16900	0.084400	1.47e-01	5.03e-01	2.45e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-GG-NER	24	4.59e-01	6.38e-01	0.06460	-0.039900	5.08e-02	7.35e-01	6.67e-01
Regulated-proteolysis-of-p75NTR	11	4.59e-01	6.38e-01	0.17700	0.168000	5.57e-02	3.34e-01	7.49e-01
SUMOylation	159	4.60e-01	6.39e-01	0.03330	0.033300	-4.64e-04	4.70e-01	9.92e-01
RET-signaling	36	4.64e-01	6.44e-01	0.09370	0.089800	2.67e-02	3.51e-01	7.82e-01
FCERI-mediated-MAPK-activation	29	4.65e-01	6.45e-01	0.06000	0.029000	-5.25e-02	7.87e-01	6.25e-01
Nitric-oxide-stimulates-guanylate-cyclase	15	4.66e-01	6.46e-01	0.15400	0.050800	1.45e-01	7.34e-01	3.31e-01
Ca2+-pathway	52	4.67e-01	6.46e-01	0.04920	0.047700	-1.23e-02	5.52e-01	8.78e-01
Meiosis	45	4.69e-01	6.48e-01	0.06220	0.062200	-5.39e-05	4.71e-01	1.00e+00
MAPK1/MAPK3-signaling	207	4.71e-01	6.49e-01	0.03580	0.007670	3.50e-02	8.50e-01	3.87e-01
Transcriptional-regulation-of-granulopoiesis	28	4.74e-01	6.53e-01	0.17700	0.132000	1.18e-01	2.26e-01	2.81e-01
PCP/CE-pathway	87	4.76e-01	6.53e-01	0.08120	-0.070300	-4.05e-02	2.57e-01	5.14e-01
Activation-of-PPARGC1A-(PGC-1alpha)-by-phosphorylation	10	4.76e-01	6.53e-01	0.20500	-0.082500	-1.88e-01	6.51e-01	3.03e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-TC-NER	63	4.77e-01	6.53e-01	0.10500	-0.086600	-5.87e-02	2.35e-01	4.21e-01
Constitutive-Signaling-by-AKT1-E17K-in-Cancer	26	4.77e-01	6.53e-01	0.14900	-0.075500	-1.29e-01	5.05e-01	2.56e-01
NR1H2-and-NR1H3-mediated-signaling	40	4.78e-01	6.53e-01	0.11900	-0.058900	-1.03e-01	5.19e-01	2.60e-01
Constitutive-Signaling-by-NOTCH1-HD+PEST-Domain-Mutants	57	4.79e-01	6.53e-01	0.04590	0.012100	-4.43e-02	8.74e-01	5.63e-01
Constitutive-Signaling-by-NOTCH1-PEST-Domain-Mutants	57	4.79e-01	6.53e-01	0.04590	0.012100	-4.43e-02	8.74e-01	5.63e-01
Signaling-by-NOTCH1-HD+PEST-Domain-Mutants-in-Cancer	57	4.79e-01	6.53e-01	0.04590	0.012100	-4.43e-02	8.74e-01	5.63e-01
Signaling-by-NOTCH1-PEST-Domain-Mutants-in-Cancer	57	4.79e-01	6.53e-01	0.04590	0.012100	-4.43e-02	8.74e-01	5.63e-01
Signaling-by-NOTCH1-in-Cancer	57	4.79e-01	6.53e-01	0.04590	0.012100	-4.43e-02	8.74e-01	5.63e-01
DNA-Double-Strand-Break-Response	40	4.79e-01	6.53e-01	0.14000	-0.111000	-8.53e-02	2.26e-01	3.51e-01
Sema3A-PAK-dependent-Axon-repulsion	15	4.81e-01	6.55e-01	0.24100	0.163000	1.77e-01	2.74e-01	2.35e-01
Assembly-and-cell-surface-presentation-of-NMDA-receptors	16	4.85e-01	6.58e-01	0.22700	0.173000	1.47e-01	2.30e-01	3.09e-01
Extension-of-Telomeres	28	4.85e-01	6.58e-01	0.10800	0.034600	1.02e-01	7.51e-01	3.48e-01
Amyloid-fiber-formation	38	4.85e-01	6.58e-01	0.14600	0.093100	1.13e-01	3.21e-01	2.29e-01
Nuclear-signaling-by-ERBB4	28	4.87e-01	6.59e-01	0.14600	0.124000	7.65e-02	2.55e-01	4.84e-01
Signaling-by-Insulin-receptor	58	4.87e-01	6.59e-01	0.05290	0.052900	-7.05e-04	4.86e-01	9.93e-01
Platelet-calcium-homeostasis	20	4.87e-01	6.59e-01	0.15500	0.070700	1.38e-01	5.84e-01	2.85e-01
Regulation-of-TNFR1-signaling	32	4.88e-01	6.60e-01	0.13500	0.070200	1.16e-01	4.92e-01	2.58e-01
Other-semaphorin-interactions	19	4.90e-01	6.61e-01	0.07150	0.034700	-6.26e-02	7.94e-01	6.37e-01
Tie2-Signaling	17	4.92e-01	6.61e-01	0.22400	-0.162000	-1.54e-01	2.47e-01	2.70e-01
SHC-mediated-cascade:FGFR1	11	4.92e-01	6.61e-01	0.09050	0.062800	-6.52e-02	7.18e-01	7.08e-01
Cytosolic-iron-sulfur-cluster-assembly	13	4.92e-01	6.61e-01	0.13300	-0.131000	-2.40e-02	4.15e-01	8.81e-01
HSP90-chaperone-cycle-for-steroid-hormone-receptors-(SHR)	31	4.92e-01	6.61e-01	0.07240	-0.072400	7.82e-05	4.85e-01	9.99e-01
TP53-Regulates-Transcription-of-Cell-Cycle-Genes	45	4.92e-01	6.61e-01	0.10300	0.091500	4.69e-02	2.88e-01	5.86e-01
IGF1R-signaling-cascade	38	4.94e-01	6.62e-01	0.11800	0.103000	5.84e-02	2.72e-01	5.34e-01
Condensation-of-Prometaphase-Chromosomes	11	4.96e-01	6.64e-01	0.26800	0.172000	2.06e-01	3.24e-01	2.37e-01
Formation-of-apoptosome	10	4.97e-01	6.64e-01	0.28900	-0.199000	-2.11e-01	2.77e-01	2.49e-01
Regulation-of-the-apoptosome-activity	10	4.97e-01	6.64e-01	0.28900	-0.199000	-2.11e-01	2.77e-01	2.49e-01
IRAK2-mediated-activation-of-TAK1-complex-upon-TLR7/8-or-9-stimulation	14	4.98e-01	6.64e-01	0.19400	0.168000	9.53e-02	2.75e-01	5.37e-01
TRAF6-mediated-induction-of-TAK1-complex-within-TLR4-complex	14	4.98e-01	6.64e-01	0.19400	0.168000	9.53e-02	2.75e-01	5.37e-01
NS1-Mediated-Effects-on-Host-Pathways	38	4.99e-01	6.65e-01	0.10000	-0.039100	-9.23e-02	6.77e-01	3.25e-01
SUMOylation-of-ubiquitinylation-proteins	37	5.02e-01	6.68e-01	0.10600	-0.044900	-9.63e-02	6.37e-01	3.11e-01
Mitotic-G2-G2/M-phases	175	5.02e-01	6.68e-01	0.03080	0.000669	3.08e-02	9.88e-01	4.84e-01
YAP1--and-WWTR1-(TAZ)-stimulated-gene-expression	14	5.03e-01	6.69e-01	0.22900	0.181000	1.41e-01	2.42e-01	3.62e-01
Defective-TPR-may-confer-susceptibility-towards-thyroid-papillary-carcinoma-(TPC)	30	5.05e-01	6.69e-01	0.09680	-0.027500	-9.28e-02	7.95e-01	3.79e-01
Regulation-of-Glucokinase-by-Glucokinase-Regulatory-Protein	30	5.05e-01	6.69e-01	0.09680	-0.027500	-9.28e-02	7.95e-01	3.79e-01
The-role-of-Nef-in-HIV-1-replication-and-disease-pathogenesis	24	5.07e-01	6.71e-01	0.08170	0.081700	1.32e-03	4.88e-01	9.91e-01
Trafficking-of-GluR2-containing-AMPA-receptors	15	5.09e-01	6.73e-01	0.19100	0.099100	1.64e-01	5.06e-01	2.72e-01
Antiviral-mechanism-by-IFN-stimulated-genes	74	5.09e-01	6.73e-01	0.08650	-0.073900	-4.49e-02	2.72e-01	5.05e-01
G-beta:gamma-signalling-through-PI3Kgamma	19	5.12e-01	6.76e-01	0.06790	0.056100	-3.83e-02	6.72e-01	7.73e-01
Nucleobase-catabolism	29	5.14e-01	6.78e-01	0.12300	-0.110000	-5.55e-02	3.06e-01	6.05e-01
Signaling-by-SCF-KIT	40	5.15e-01	6.78e-01	0.14100	0.103000	9.64e-02	2.60e-01	2.91e-01
Chromosome-Maintenance	52	5.16e-01	6.78e-01	0.12400	0.085800	8.94e-02	2.85e-01	2.65e-01
Aggrephagy	18	5.16e-01	6.78e-01	0.17700	0.094700	1.50e-01	4.87e-01	2.71e-01
NOTCH3-Activation-and-Transmission-of-Signal-to-the-Nucleus	25	5.21e-01	6.84e-01	0.08090	-0.004150	-8.08e-02	9.71e-01	4.85e-01
Caspase-activation-via-Death-Receptors-in-the-presence-of-ligand	13	5.23e-01	6.86e-01	0.24400	0.179000	1.66e-01	2.64e-01	3.01e-01
Adaptive-Immune-System	558	5.24e-01	6.87e-01	0.01720	0.017100	6.61e-04	4.91e-01	9.79e-01
Interaction-between-L1-and-Ankyrins	22	5.25e-01	6.87e-01	0.15300	-0.131000	-7.82e-02	2.86e-01	5.25e-01
NOTCH4-Activation-and-Transmission-of-Signal-to-the-Nucleus	10	5.28e-01	6.90e-01	0.11700	0.005500	-1.17e-01	9.76e-01	5.23e-01
Plasma-lipoprotein-remodeling	19	5.29e-01	6.90e-01	0.12600	-0.118000	-4.23e-02	3.71e-01	7.50e-01
Toll-Like-Receptor-4-(TLR4)-Cascade	113	5.30e-01	6.90e-01	0.05670	0.051900	2.27e-02	3.41e-01	6.77e-01
Signaling-by-FGFR-in-disease	53	5.30e-01	6.90e-01	0.12000	-0.088000	-8.10e-02	2.68e-01	3.08e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes	34	5.30e-01	6.90e-01	0.15000	0.104000	1.08e-01	2.94e-01	2.75e-01
FLT3-Signaling	220	5.31e-01	6.90e-01	0.02240	-0.004790	2.19e-02	9.03e-01	5.77e-01
Prolonged-ERK-activation-events	13	5.32e-01	6.90e-01	0.08770	0.083900	-2.56e-02	6.01e-01	8.73e-01
Protein-folding	84	5.32e-01	6.90e-01	0.08150	0.044300	6.84e-02	4.83e-01	2.79e-01
Regulation-of-TP53-Activity	148	5.33e-01	6.91e-01	0.03420	-0.034100	-3.36e-03	4.75e-01	9.44e-01
CD28-dependent-PI3K/Akt-signaling	21	5.34e-01	6.91e-01	0.06350	-0.031900	5.50e-02	8.00e-01	6.63e-01
Interleukin-3,-Interleukin-5-and-GM-CSF-signaling	38	5.35e-01	6.92e-01	0.14000	0.095300	1.03e-01	3.09e-01	2.73e-01
Neuronal-System	251	5.35e-01	6.92e-01	0.05180	0.031600	4.10e-02	3.90e-01	2.65e-01
Frs2-mediated-activation	11	5.37e-01	6.93e-01	0.11000	0.110000	-4.75e-03	5.27e-01	9.78e-01
Signaling-by-cytosolic-FGFR1-fusion-mutants	18	5.37e-01	6.93e-01	0.06620	-0.045700	4.80e-02	7.37e-01	7.25e-01
SHC-mediated-cascade:FGFR4	12	5.38e-01	6.93e-01	0.19500	-0.095000	-1.70e-01	5.69e-01	3.07e-01
Signaling-by-WNT	233	5.39e-01	6.93e-01	0.04910	-0.027000	-4.10e-02	4.79e-01	2.82e-01
SUMOylation-of-DNA-damage-response-and-repair-proteins	73	5.39e-01	6.93e-01	0.06270	-0.020700	-5.92e-02	7.60e-01	3.82e-01
MyD88-dependent-cascade-initiated-on-endosome	84	5.40e-01	6.93e-01	0.03780	0.004450	-3.75e-02	9.44e-01	5.53e-01
Toll-Like-Receptor-7/8-(TLR7/8)-Cascade	84	5.40e-01	6.93e-01	0.03780	0.004450	-3.75e-02	9.44e-01	5.53e-01
ATF6-(ATF6-alpha)-activates-chaperones	12	5.41e-01	6.94e-01	0.23100	-0.184000	-1.40e-01	2.69e-01	4.02e-01
Scavenging-by-Class-A-Receptors	16	5.42e-01	6.95e-01	0.21500	0.154000	1.50e-01	2.86e-01	3.00e-01
Dual-Incision-in-GG-NER	40	5.44e-01	6.96e-01	0.11900	-0.066900	-9.85e-02	4.65e-01	2.81e-01
Polo-like-kinase-mediated-events	14	5.44e-01	6.96e-01	0.22900	0.162000	1.63e-01	2.95e-01	2.92e-01
NEP/NS2-Interacts-with-the-Cellular-Export-Machinery	30	5.45e-01	6.96e-01	0.12700	-0.064500	-1.09e-01	5.41e-01	3.02e-01
Cytochrome-c-mediated-apoptotic-response	12	5.46e-01	6.96e-01	0.17900	-0.078200	-1.61e-01	6.39e-01	3.35e-01
Costimulation-by-the-CD28-family	52	5.46e-01	6.96e-01	0.04490	-0.009390	4.39e-02	9.07e-01	5.85e-01
ERBB2-Activates-PTK6-Signaling	12	5.47e-01	6.97e-01	0.20500	0.174000	1.08e-01	2.97e-01	5.19e-01
Deactivation-of-the-beta-catenin-transactivating-complex	39	5.48e-01	6.97e-01	0.11900	-0.066200	-9.88e-02	4.74e-01	2.86e-01
Fanconi-Anemia-Pathway	34	5.53e-01	7.03e-01	0.06320	-0.063200	1.27e-04	5.24e-01	9.99e-01
NOTCH1-Intracellular-Domain-Regulates-Transcription	46	5.54e-01	7.03e-01	0.04190	0.036600	-2.03e-02	6.68e-01	8.11e-01
Regulation-of-TP53-Activity-through-Association-with-Co-factors	11	5.55e-01	7.04e-01	0.17200	-0.158000	-6.78e-02	3.63e-01	6.97e-01
Host-Interactions-with-Influenza-Factors	39	5.59e-01	7.09e-01	0.07090	-0.014200	-6.95e-02	8.78e-01	4.53e-01
Inwardly-rectifying-K+-channels	20	5.61e-01	7.10e-01	0.16500	-0.136000	-9.39e-02	2.92e-01	4.67e-01
G2/M-Transition	173	5.61e-01	7.10e-01	0.02260	-0.007700	2.12e-02	8.62e-01	6.30e-01
Recruitment-and-ATM-mediated-phosphorylation-of-repair-and-signaling-proteins-at-DNA-double-strand-breaks	39	5.64e-01	7.12e-01	0.12000	-0.097700	-6.91e-02	2.91e-01	4.55e-01
Transcriptional-regulation-by-the-AP-2-(TFAP2)-family-of-transcription-factors	24	5.65e-01	7.13e-01	0.16100	0.126000	1.01e-01	2.85e-01	3.92e-01
Insulin-receptor-signalling-cascade	39	5.65e-01	7.13e-01	0.05420	0.054000	-4.89e-03	5.60e-01	9.58e-01
Signaling-by-NOTCH2	30	5.66e-01	7.13e-01	0.14800	0.097400	1.12e-01	3.56e-01	2.88e-01
MET-activates-RAS-signaling	10	5.68e-01	7.15e-01	0.09950	0.097600	-1.95e-02	5.93e-01	9.15e-01
Mismatch-Repair	12	5.70e-01	7.17e-01	0.17300	-0.155000	-7.62e-02	3.52e-01	6.48e-01
Translesion-synthesis-by-POLK	17	5.71e-01	7.17e-01	0.07070	-0.066500	2.40e-02	6.35e-01	8.64e-01
Depolymerisation-of-the-Nuclear-Lamina	15	5.72e-01	7.17e-01	0.18900	0.155000	1.08e-01	2.99e-01	4.68e-01
Dectin-2-family	11	5.72e-01	7.18e-01	0.21800	0.180000	1.24e-01	3.01e-01	4.78e-01
tRNA-modification-in-the-nucleus-and-cytosol	41	5.74e-01	7.19e-01	0.05810	-0.058100	-2.77e-03	5.20e-01	9.76e-01
Intrinsic-Pathway-for-Apoptosis	47	5.75e-01	7.19e-01	0.04850	0.048300	-4.57e-03	5.67e-01	9.57e-01
InlB-mediated-entry-of-Listeria-monocytogenes-into-host-cell	13	5.76e-01	7.20e-01	0.22000	0.168000	1.43e-01	2.95e-01	3.73e-01
MET-receptor-recycling	10	5.78e-01	7.22e-01	0.23700	0.190000	1.42e-01	2.98e-01	4.36e-01
SHC-mediated-cascade:FGFR3	12	5.79e-01	7.22e-01	0.23200	-0.155000	-1.72e-01	3.51e-01	3.01e-01
Dual-incision-in-TC-NER	64	5.79e-01	7.22e-01	0.10200	-0.073400	-7.02e-02	3.11e-01	3.32e-01
Negative-regulation-of-FGFR4-signaling	23	5.80e-01	7.22e-01	0.13900	-0.072500	-1.19e-01	5.48e-01	3.23e-01
SHC-mediated-cascade:FGFR2	14	5.82e-01	7.24e-01	0.10300	-0.009910	-1.02e-01	9.49e-01	5.08e-01
Other-interleukin-signaling	19	5.82e-01	7.24e-01	0.11600	0.038800	1.09e-01	7.70e-01	4.11e-01
Apoptotic-factor-mediated-response	15	5.86e-01	7.27e-01	0.12300	-0.036200	-1.17e-01	8.08e-01	4.31e-01
Activation-of-BAD-and-translocation-to-mitochondria	15	5.86e-01	7.27e-01	0.15700	0.139000	7.33e-02	3.51e-01	6.23e-01
Glutamate-binding,-activation-of-AMPA-receptors-and-synaptic-plasticity	24	5.87e-01	7.27e-01	0.15300	0.092900	1.21e-01	4.31e-01	3.03e-01
Trafficking-of-AMPA-receptors	24	5.87e-01	7.27e-01	0.15300	0.092900	1.21e-01	4.31e-01	3.03e-01
Listeria-monocytogenes-entry-into-host-cells	16	5.88e-01	7.27e-01	0.19500	0.148000	1.27e-01	3.04e-01	3.79e-01
PCNA-Dependent-Long-Patch-Base-Excision-Repair	20	5.92e-01	7.29e-01	0.07240	-0.006680	7.21e-02	9.59e-01	5.77e-01
AMER1-mutants-destabilize-the-destruction-complex	14	5.94e-01	7.29e-01	0.15300	0.138000	6.65e-02	3.72e-01	6.67e-01
APC-truncation-mutants-have-impaired-AXIN-binding	14	5.94e-01	7.29e-01	0.15300	0.138000	6.65e-02	3.72e-01	6.67e-01
AXIN-missense-mutants-destabilize-the-destruction-complex	14	5.94e-01	7.29e-01	0.15300	0.138000	6.65e-02	3.72e-01	6.67e-01
AXIN-mutants-destabilize-the-destruction-complex,-activating-WNT-signaling	14	5.94e-01	7.29e-01	0.15300	0.138000	6.65e-02	3.72e-01	6.67e-01
Truncations-of-AMER1-destabilize-the-destruction-complex	14	5.94e-01	7.29e-01	0.15300	0.138000	6.65e-02	3.72e-01	6.67e-01
truncated-APC-mutants-destabilize-the-destruction-complex	14	5.94e-01	7.29e-01	0.15300	0.138000	6.65e-02	3.72e-01	6.67e-01
HDR-through-MMEJ-(alt-NHEJ)	10	5.97e-01	7.33e-01	0.20900	-0.111000	-1.77e-01	5.45e-01	3.33e-01
NF-kB-activation-through-FADD/RIP-1-pathway-mediated-by-caspase-8-and--10	10	5.98e-01	7.33e-01	0.08080	-0.056000	5.83e-02	7.59e-01	7.50e-01
Activation-of-BH3-only-proteins	28	5.99e-01	7.34e-01	0.12100	0.104000	6.20e-02	3.41e-01	5.70e-01
Interactions-of-Rev-with-host-cellular-proteins	34	6.01e-01	7.34e-01	0.10400	-0.049500	-9.11e-02	6.18e-01	3.58e-01
Regulation-of-localization-of-FOXO-transcription-factors	12	6.03e-01	7.34e-01	0.19800	-0.112000	-1.64e-01	5.03e-01	3.26e-01
TAK1-activates-NFkB-by-phosphorylation-and-activation-of-IKKs-complex	24	6.03e-01	7.34e-01	0.07410	0.005390	7.39e-02	9.64e-01	5.31e-01
PRC2-methylates-histones-and-DNA	13	6.03e-01	7.34e-01	0.09110	0.004290	-9.10e-02	9.79e-01	5.70e-01
Membrane-binding-and-targetting-of-GAG-proteins	14	6.04e-01	7.34e-01	0.13900	0.128000	5.30e-02	4.05e-01	7.31e-01
Synthesis-And-Processing-Of-GAG,-GAGPOL-Polyproteins	14	6.04e-01	7.34e-01	0.13900	0.128000	5.30e-02	4.05e-01	7.31e-01
Glutamate-and-glutamine-metabolism	10	6.04e-01	7.34e-01	0.16000	-0.058300	-1.49e-01	7.50e-01	4.14e-01
Regulation-of-PTEN-mRNA-translation	11	6.04e-01	7.34e-01	0.19400	-0.101000	-1.66e-01	5.61e-01	3.42e-01
Telomere-Maintenance	34	6.06e-01	7.35e-01	0.06940	0.012900	6.82e-02	8.96e-01	4.92e-01
Negative-regulation-of-FGFR3-signaling	23	6.06e-01	7.35e-01	0.15900	-0.104000	-1.20e-01	3.88e-01	3.19e-01
IRS-related-events-triggered-by-IGF1R	37	6.06e-01	7.35e-01	0.09580	0.085100	4.40e-02	3.71e-01	6.43e-01
Constitutive-Signaling-by-Overexpressed-ERBB2	10	6.07e-01	7.36e-01	0.24400	0.178000	1.67e-01	3.29e-01	3.61e-01
Inositol-phosphate-metabolism	42	6.09e-01	7.37e-01	0.11200	0.068400	8.87e-02	4.43e-01	3.20e-01
Formation-of-RNA-Pol-II-elongation-complex	56	6.12e-01	7.38e-01	0.09830	-0.076700	-6.16e-02	3.21e-01	4.25e-01
RNA-Polymerase-II-Transcription-Elongation	56	6.12e-01	7.38e-01	0.09830	-0.076700	-6.16e-02	3.21e-01	4.25e-01
SUMOylation-of-immune-response-proteins	11	6.12e-01	7.38e-01	0.23200	0.165000	1.63e-01	3.43e-01	3.49e-01
Interleukin-20-family-signaling	14	6.13e-01	7.38e-01	0.19100	-0.116000	-1.52e-01	4.53e-01	3.24e-01
RA-biosynthesis-pathway	13	6.14e-01	7.38e-01	0.19100	-0.110000	-1.56e-01	4.91e-01	3.30e-01
Detoxification-of-Reactive-Oxygen-Species	33	6.14e-01	7.38e-01	0.11700	-0.065000	-9.67e-02	5.19e-01	3.36e-01
Synthesis-of-Leukotrienes-(LT)-and-Eoxins-(EX)	12	6.14e-01	7.38e-01	0.08440	0.016500	-8.27e-02	9.21e-01	6.20e-01
NoRC-negatively-regulates-rRNA-expression	47	6.18e-01	7.41e-01	0.10800	-0.082800	-6.87e-02	3.27e-01	4.15e-01
Norepinephrine-Neurotransmitter-Release-Cycle	12	6.18e-01	7.41e-01	0.20100	0.119000	1.62e-01	4.77e-01	3.31e-01
Transcription-of-E2F-targets-under-negative-control-by-DREAM-complex	18	6.21e-01	7.44e-01	0.10600	0.101000	3.12e-02	4.58e-01	8.19e-01
Transferrin-endocytosis-and-recycling	25	6.23e-01	7.45e-01	0.10500	0.095900	4.30e-02	4.07e-01	7.10e-01
Regulation-of-TP53-Expression-and-Degradation	35	6.24e-01	7.45e-01	0.12500	-0.094300	-8.26e-02	3.34e-01	3.98e-01
SUMOylation-of-transcription-factors	15	6.24e-01	7.45e-01	0.06610	0.030000	-5.89e-02	8.41e-01	6.93e-01
Negative-regulation-of-FGFR1-signaling	22	6.24e-01	7.45e-01	0.06440	0.007490	-6.40e-02	9.52e-01	6.03e-01
PERK-regulates-gene-expression	29	6.25e-01	7.46e-01	0.08960	-0.083800	-3.17e-02	4.35e-01	7.68e-01
Phase-2---plateau-phase	16	6.26e-01	7.46e-01	0.06300	-0.031200	5.47e-02	8.29e-01	7.05e-01
Lewis-blood-group-biosynthesis	10	6.27e-01	7.46e-01	0.16200	0.149000	6.42e-02	4.16e-01	7.25e-01
Negative-regulation-of-FGFR2-signaling	25	6.30e-01	7.49e-01	0.08890	-0.026600	-8.49e-02	8.18e-01	4.63e-01
DNA-Repair	271	6.31e-01	7.50e-01	0.02550	-0.024700	-6.29e-03	4.86e-01	8.59e-01
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	70	6.31e-01	7.50e-01	0.08920	-0.064000	-6.21e-02	3.55e-01	3.69e-01
CTLA4-inhibitory-signaling	19	6.32e-01	7.50e-01	0.11000	-0.103000	-3.96e-02	4.38e-01	7.65e-01
Assembly-of-active-LPL-and-LIPC-lipase-complexes	11	6.37e-01	7.51e-01	0.15200	-0.061100	-1.40e-01	7.26e-01	4.22e-01
Condensation-of-Prophase-Chromosomes	14	6.37e-01	7.51e-01	0.18400	0.112000	1.46e-01	4.69e-01	3.44e-01
mRNA-decay-by-3'-to-5'-exoribonuclease	15	6.39e-01	7.51e-01	0.08610	-0.086000	-3.96e-03	5.64e-01	9.79e-01
Interleukin-2-family-signaling	32	6.40e-01	7.51e-01	0.12900	0.095100	8.69e-02	3.52e-01	3.95e-01
Translesion-synthesis-by-REV1	16	6.40e-01	7.51e-01	0.08940	-0.088700	-1.10e-02	5.39e-01	9.40e-01
Plasma-lipoprotein-assembly	14	6.40e-01	7.51e-01	0.06610	0.031200	-5.83e-02	8.40e-01	7.06e-01
Surfactant-metabolism	15	6.41e-01	7.51e-01	0.18400	0.140000	1.19e-01	3.47e-01	4.25e-01
Misspliced-GSK3beta-mutants-stabilize-beta-catenin	15	6.41e-01	7.51e-01	0.10900	0.105000	2.98e-02	4.82e-01	8.41e-01
S33-mutants-of-beta-catenin-aren't-phosphorylated	15	6.41e-01	7.51e-01	0.10900	0.105000	2.98e-02	4.82e-01	8.41e-01
S37-mutants-of-beta-catenin-aren't-phosphorylated	15	6.41e-01	7.51e-01	0.10900	0.105000	2.98e-02	4.82e-01	8.41e-01
S45-mutants-of-beta-catenin-aren't-phosphorylated	15	6.41e-01	7.51e-01	0.10900	0.105000	2.98e-02	4.82e-01	8.41e-01
T41-mutants-of-beta-catenin-aren't-phosphorylated	15	6.41e-01	7.51e-01	0.10900	0.105000	2.98e-02	4.82e-01	8.41e-01
phosphorylation-site-mutants-of-CTNNB1-are-not-targeted-to-the-proteasome-by-the-destruction-complex	15	6.41e-01	7.51e-01	0.10900	0.105000	2.98e-02	4.82e-01	8.41e-01
N-glycan-trimming-in-the-ER-and-Calnexin/Calreticulin-cycle	34	6.41e-01	7.51e-01	0.04160	0.035100	-2.25e-02	7.24e-01	8.21e-01
Signaling-by-NTRK3-(TRKC)	17	6.43e-01	7.52e-01	0.16400	0.131000	9.83e-02	3.50e-01	4.83e-01
Transport-of-bile-salts-and-organic-acids,-metal-ions-and-amine-compounds	46	6.45e-01	7.54e-01	0.08740	0.075000	4.48e-02	3.79e-01	5.99e-01
Platelet-homeostasis	64	6.47e-01	7.56e-01	0.09080	0.064200	6.42e-02	3.75e-01	3.75e-01
Nonhomologous-End-Joining-(NHEJ)	32	6.51e-01	7.59e-01	0.07600	-0.072500	-2.29e-02	4.78e-01	8.23e-01
Association-of-TriC/CCT-with-target-proteins-during-biosynthesis	37	6.51e-01	7.60e-01	0.04910	-0.049000	3.23e-03	6.06e-01	9.73e-01
Erythropoietin-activates-Phosphoinositide-3-kinase-(PI3K)	11	6.55e-01	7.62e-01	0.11600	0.113000	2.50e-02	5.16e-01	8.86e-01
Adrenaline,noradrenaline-inhibits-insulin-secretion	21	6.55e-01	7.62e-01	0.12300	0.107000	6.02e-02	3.96e-01	6.33e-01
TP53-Regulates-Transcription-of-DNA-Repair-Genes	59	6.62e-01	7.69e-01	0.02990	-0.021700	2.05e-02	7.73e-01	7.86e-01
Complement-cascade	26	6.68e-01	7.76e-01	0.12400	-0.072700	-1.01e-01	5.21e-01	3.74e-01
Nicotinamide-salvaging	16	6.69e-01	7.77e-01	0.06130	-0.021700	5.73e-02	8.80e-01	6.92e-01
Response-of-Mtb-to-phagocytosis	21	6.71e-01	7.78e-01	0.11100	-0.049100	-9.92e-02	6.97e-01	4.31e-01
Oncogene-Induced-Senescence	32	6.72e-01	7.78e-01	0.04520	0.043700	-1.15e-02	6.69e-01	9.10e-01
Tristetraprolin-(TTP,-ZFP36)-binds-and-destabilizes-mRNA	16	6.73e-01	7.78e-01	0.06450	-0.062600	1.52e-02	6.65e-01	9.16e-01
Signalling-to-ERKs	30	6.73e-01	7.78e-01	0.04710	0.045700	-1.11e-02	6.65e-01	9.16e-01
Interleukin-7-signaling	20	6.77e-01	7.82e-01	0.07900	-0.014000	-7.78e-02	9.14e-01	5.47e-01
Translesion-synthesis-by-POLI	17	6.84e-01	7.90e-01	0.05320	-0.037400	3.79e-02	7.90e-01	7.87e-01
RNA-Polymerase-III-Transcription-Termination	21	6.85e-01	7.90e-01	0.05120	0.047200	-1.98e-02	7.08e-01	8.75e-01
Plasma-lipoprotein-clearance	27	6.85e-01	7.90e-01	0.12500	-0.078900	-9.67e-02	4.78e-01	3.85e-01
Competing-endogenous-RNAs-(ceRNAs)-regulate-PTEN-translation	10	6.88e-01	7.91e-01	0.19800	-0.119000	-1.57e-01	5.14e-01	3.89e-01
G-alpha-(z)-signalling-events	37	6.88e-01	7.91e-01	0.07910	0.034000	7.14e-02	7.21e-01	4.52e-01
Export-of-Viral-Ribonucleoproteins-from-Nucleus	31	6.89e-01	7.92e-01	0.09400	-0.045600	-8.22e-02	6.60e-01	4.28e-01
ER-Quality-Control-Compartment-(ERQC)	20	6.90e-01	7.92e-01	0.15000	0.104000	1.07e-01	4.19e-01	4.07e-01
ROS-and-RNS-production-in-phagocytes	28	6.97e-01	7.99e-01	0.04090	0.024500	-3.27e-02	8.23e-01	7.64e-01
Interleukin-6-family-signaling	18	7.03e-01	8.03e-01	0.15200	0.101000	1.13e-01	4.60e-01	4.05e-01
Acyl-chain-remodelling-of-PS	14	7.03e-01	8.03e-01	0.11500	-0.043300	-1.07e-01	7.79e-01	4.90e-01
eNOS-activation	10	7.04e-01	8.03e-01	0.13200	-0.123000	-4.68e-02	4.99e-01	7.98e-01
Phase-0---rapid-depolarisation	30	7.05e-01	8.03e-01	0.11700	-0.087400	-7.83e-02	4.08e-01	4.58e-01
TNFR1-induced-NFkappaB-signaling-pathway	25	7.05e-01	8.03e-01	0.13000	0.091300	9.27e-02	4.30e-01	4.23e-01
Rev-mediated-nuclear-export-of-HIV-RNA	33	7.05e-01	8.03e-01	0.08720	-0.041600	-7.66e-02	6.79e-01	4.47e-01
RNA-Polymerase-III-Abortive-And-Retractive-Initiation	39	7.06e-01	8.03e-01	0.03400	0.027000	-2.06e-02	7.71e-01	8.24e-01
RNA-Polymerase-III-Transcription	39	7.06e-01	8.03e-01	0.03400	0.027000	-2.06e-02	7.71e-01	8.24e-01
IRAK2-mediated-activation-of-TAK1-complex	10	7.06e-01	8.03e-01	0.08960	-0.000215	-8.96e-02	9.99e-01	6.24e-01
PKA-activation-in-glucagon-signalling	15	7.06e-01	8.03e-01	0.05740	0.052200	-2.40e-02	7.26e-01	8.72e-01
Metalloprotease-DUBs	16	7.08e-01	8.05e-01	0.14900	0.088900	1.19e-01	5.38e-01	4.09e-01
Presynaptic-function-of-Kainate-receptors	15	7.09e-01	8.05e-01	0.07240	0.072400	-1.79e-04	6.27e-01	9.99e-01
Regulation-of-TP53-Degradation	34	7.13e-01	8.08e-01	0.10600	-0.081500	-6.78e-02	4.11e-01	4.94e-01
CD28-dependent-Vav1-pathway	11	7.13e-01	8.08e-01	0.19100	0.129000	1.41e-01	4.58e-01	4.18e-01
SUMOylation-of-transcription-cofactors	42	7.15e-01	8.10e-01	0.05590	-0.014700	-5.39e-02	8.69e-01	5.46e-01
Signaling-by-FGFR	67	7.19e-01	8.13e-01	0.06620	-0.036200	-5.55e-02	6.09e-01	4.33e-01
Cleavage-of-the-damaged-purine	10	7.23e-01	8.15e-01	0.17700	0.102000	1.45e-01	5.76e-01	4.27e-01
Depurination	10	7.23e-01	8.15e-01	0.17700	0.102000	1.45e-01	5.76e-01	4.27e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-purine	10	7.23e-01	8.15e-01	0.17700	0.102000	1.45e-01	5.76e-01	4.27e-01
Interleukin-2-signaling	10	7.25e-01	8.16e-01	0.07350	0.017400	-7.14e-02	9.24e-01	6.96e-01
Infection-with-Mycobacterium-tuberculosis	24	7.30e-01	8.21e-01	0.04170	0.022600	-3.50e-02	8.48e-01	7.67e-01
Miscellaneous-transport-and-binding-events	20	7.31e-01	8.21e-01	0.13600	-0.090300	-1.01e-01	4.84e-01	4.33e-01
Cytochrome-P450---arranged-by-substrate-type	27	7.31e-01	8.21e-01	0.10600	-0.060700	-8.65e-02	5.85e-01	4.36e-01
Estrogen-dependent-gene-expression	83	7.31e-01	8.21e-01	0.04710	-0.019400	-4.29e-02	7.60e-01	5.00e-01
Serotonin-Neurotransmitter-Release-Cycle	13	7.33e-01	8.22e-01	0.12500	0.056100	1.12e-01	7.26e-01	4.85e-01
Signaling-by-FGFR3-fusions-in-cancer	10	7.34e-01	8.22e-01	0.13000	-0.050000	-1.20e-01	7.84e-01	5.13e-01
Generation-of-second-messenger-molecules	16	7.34e-01	8.22e-01	0.08690	0.083900	2.29e-02	5.62e-01	8.74e-01
PKA-activation	15	7.34e-01	8.22e-01	0.10200	-0.037200	-9.54e-02	8.03e-01	5.23e-01
DNA-Double-Strand-Break-Repair	123	7.36e-01	8.23e-01	0.01800	-0.011000	1.42e-02	8.33e-01	7.86e-01
Butyrate-Response-Factor-1-(BRF1)-binds-and-destabilizes-mRNA	16	7.38e-01	8.24e-01	0.11200	-0.099800	-5.03e-02	4.90e-01	7.28e-01
Synthesis-of-PIPs-at-the-early-endosome-membrane	16	7.40e-01	8.26e-01	0.13800	0.111000	8.12e-02	4.42e-01	5.74e-01
RUNX3-regulates-NOTCH-signaling	14	7.41e-01	8.26e-01	0.16100	0.113000	1.15e-01	4.66e-01	4.57e-01
Basigin-interactions	19	7.45e-01	8.30e-01	0.13200	0.102000	8.42e-02	4.43e-01	5.26e-01
Protein-methylation	13	7.45e-01	8.30e-01	0.14500	-0.120000	-8.20e-02	4.54e-01	6.09e-01
Purine-catabolism	16	7.47e-01	8.30e-01	0.05790	-0.008910	5.72e-02	9.51e-01	6.92e-01
DCC-mediated-attractive-signaling	13	7.48e-01	8.30e-01	0.08810	-0.086100	-1.88e-02	5.91e-01	9.07e-01
Beta-catenin-independent-WNT-signaling	131	7.48e-01	8.30e-01	0.04780	-0.038400	-2.85e-02	4.49e-01	5.73e-01
Resolution-of-AP-sites-via-the-multiple-nucleotide-patch-replacement-pathway	24	7.48e-01	8.30e-01	0.04070	-0.019400	3.57e-02	8.69e-01	7.62e-01
Epigenetic-regulation-of-gene-expression	87	7.52e-01	8.33e-01	0.02520	0.025000	-3.03e-03	6.88e-01	9.61e-01
VxPx-cargo-targeting-to-cilium	18	7.52e-01	8.33e-01	0.12700	0.102000	7.59e-02	4.54e-01	5.77e-01
Regulation-of-necroptotic-cell-death	12	7.54e-01	8.34e-01	0.06460	0.012000	-6.34e-02	9.43e-01	7.04e-01
Regulation-of-insulin-secretion	59	7.56e-01	8.35e-01	0.04120	0.009280	4.01e-02	9.02e-01	5.95e-01
PKA-mediated-phosphorylation-of-CREB	17	7.57e-01	8.35e-01	0.09210	-0.034100	-8.56e-02	8.08e-01	5.41e-01
Negative-epigenetic-regulation-of-rRNA-expression	50	7.57e-01	8.35e-01	0.07160	-0.059400	-4.00e-02	4.68e-01	6.25e-01
Signalling-to-RAS	17	7.58e-01	8.35e-01	0.13600	0.104000	8.80e-02	4.57e-01	5.30e-01
Diseases-of-signal-transduction	331	7.58e-01	8.35e-01	0.02730	0.023000	1.47e-02	4.75e-01	6.47e-01
Regulation-of-gene-expression-in-late-stage-(branching-morphogenesis)-pancreatic-bud-precursor-cells	12	7.64e-01	8.40e-01	0.16100	0.122000	1.06e-01	4.65e-01	5.26e-01
Calnexin/calreticulin-cycle	25	7.64e-01	8.40e-01	0.08230	0.074100	3.58e-02	5.21e-01	7.56e-01
Gamma-carboxylation,-hypusine-formation-and-arylsulfatase-activation	27	7.67e-01	8.41e-01	0.09190	0.077600	4.93e-02	4.85e-01	6.57e-01
Suppression-of-phagosomal-maturation	13	7.68e-01	8.41e-01	0.05120	0.031100	-4.06e-02	8.46e-01	8.00e-01
KSRP-(KHSRP)-binds-and-destabilizes-mRNA	16	7.68e-01	8.41e-01	0.06860	-0.068100	-8.34e-03	6.37e-01	9.54e-01
Resolution-of-Abasic-Sites-(AP-sites)	37	7.68e-01	8.41e-01	0.05350	0.014600	5.14e-02	8.78e-01	5.89e-01
Regulation-of-Complement-cascade	22	7.68e-01	8.41e-01	0.11200	-0.068400	-8.92e-02	5.79e-01	4.69e-01
Platelet-sensitization-by-LDL	16	7.72e-01	8.44e-01	0.13100	-0.104000	-7.94e-02	4.73e-01	5.82e-01
GABA-receptor-activation	32	7.72e-01	8.44e-01	0.09790	0.072600	6.57e-02	4.77e-01	5.21e-01
Insulin-receptor-recycling	20	7.75e-01	8.45e-01	0.04090	0.033800	-2.30e-02	7.94e-01	8.58e-01
MyD88:MAL(TIRAP)-cascade-initiated-on-plasma-membrane	88	7.77e-01	8.45e-01	0.02950	-0.004340	-2.91e-02	9.44e-01	6.37e-01
Toll-Like-Receptor-2-(TLR2)-Cascade	88	7.77e-01	8.45e-01	0.02950	-0.004340	-2.91e-02	9.44e-01	6.37e-01
Toll-Like-Receptor-TLR1:TLR2-Cascade	88	7.77e-01	8.45e-01	0.02950	-0.004340	-2.91e-02	9.44e-01	6.37e-01
Toll-Like-Receptor-TLR6:TLR2-Cascade	88	7.77e-01	8.45e-01	0.02950	-0.004340	-2.91e-02	9.44e-01	6.37e-01
Downregulation-of-ERBB2-signaling	27	7.79e-01	8.47e-01	0.03460	0.027700	-2.08e-02	8.04e-01	8.52e-01
Base-Excision-Repair	44	7.81e-01	8.48e-01	0.04410	0.009330	4.31e-02	9.15e-01	6.21e-01
Regulation-of-innate-immune-responses-to-cytosolic-DNA	13	7.82e-01	8.49e-01	0.14300	0.088300	1.12e-01	5.81e-01	4.83e-01
Activated-NOTCH1-Transmits-Signal-to-the-Nucleus	28	7.83e-01	8.49e-01	0.03590	0.013200	-3.34e-02	9.04e-01	7.60e-01
CLEC7A-(Dectin-1)-induces-NFAT-activation	11	7.84e-01	8.49e-01	0.15800	-0.121000	-1.02e-01	4.86e-01	5.59e-01
G-protein-beta:gamma-signalling	26	7.88e-01	8.52e-01	0.04430	0.044300	-1.97e-03	6.96e-01	9.86e-01
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants	15	7.88e-01	8.52e-01	0.13800	-0.100000	-9.44e-02	5.00e-01	5.27e-01
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer	15	7.88e-01	8.52e-01	0.13800	-0.100000	-9.44e-02	5.00e-01	5.27e-01
Nicotinate-metabolism	27	7.91e-01	8.55e-01	0.03560	-0.032900	1.36e-02	7.67e-01	9.03e-01
Activation-of-GABAB-receptors	27	7.92e-01	8.55e-01	0.10200	0.070200	7.37e-02	5.28e-01	5.08e-01
GABA-B-receptor-activation	27	7.92e-01	8.55e-01	0.10200	0.070200	7.37e-02	5.28e-01	5.08e-01
Signaling-by-ERBB2	47	7.95e-01	8.57e-01	0.04240	0.041200	1.02e-02	6.25e-01	9.04e-01
Regulation-of-gene-expression-by-Hypoxia-inducible-Factor	10	7.99e-01	8.59e-01	0.08700	-0.017300	-8.52e-02	9.24e-01	6.41e-01
Downregulation-of-ERBB2:ERBB3-signaling	13	7.99e-01	8.59e-01	0.14200	-0.094800	-1.06e-01	5.54e-01	5.07e-01
Physiological-factors	11	8.00e-01	8.60e-01	0.10600	0.041900	9.76e-02	8.10e-01	5.75e-01
TNF-signaling	42	8.07e-01	8.65e-01	0.06610	0.055900	3.52e-02	5.31e-01	6.93e-01
G-beta:gamma-signalling-through-PLC-beta	14	8.07e-01	8.65e-01	0.04800	0.045000	-1.66e-02	7.71e-01	9.14e-01
MASTL-Facilitates-Mitotic-Progression	10	8.08e-01	8.65e-01	0.09510	0.090800	2.82e-02	6.19e-01	8.77e-01
Ion-channel-transport	110	8.09e-01	8.65e-01	0.03120	-0.029100	-1.12e-02	5.98e-01	8.40e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-2-Promoter	25	8.09e-01	8.65e-01	0.09690	-0.075300	-6.09e-02	5.15e-01	5.98e-01
DAG-and-IP3-signaling	36	8.10e-01	8.65e-01	0.05910	-0.053700	-2.47e-02	5.77e-01	7.98e-01
Integration-of-energy-metabolism	86	8.10e-01	8.65e-01	0.05220	-0.040500	-3.29e-02	5.16e-01	5.99e-01
Estrogen-dependent-nuclear-events-downstream-of-ESR-membrane-signaling	22	8.10e-01	8.65e-01	0.08390	0.073300	4.07e-02	5.52e-01	7.41e-01
Base-Excision-Repair,-AP-Site-Formation	17	8.11e-01	8.65e-01	0.10500	0.057100	8.75e-02	6.83e-01	5.32e-01
Meiotic-recombination	23	8.16e-01	8.69e-01	0.05610	-0.012600	-5.47e-02	9.17e-01	6.50e-01
Signaling-by-Erythropoietin	24	8.20e-01	8.73e-01	0.03290	0.027100	-1.87e-02	8.18e-01	8.74e-01
E2F-mediated-regulation-of-DNA-replication	22	8.21e-01	8.73e-01	0.08090	0.039100	7.09e-02	7.51e-01	5.65e-01
NRIF-signals-cell-death-from-the-nucleus	16	8.26e-01	8.78e-01	0.09110	0.080500	4.26e-02	5.77e-01	7.68e-01
VEGFR2-mediated-cell-proliferation	19	8.26e-01	8.78e-01	0.09240	0.049200	7.82e-02	7.11e-01	5.55e-01
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain	18	8.28e-01	8.79e-01	0.06390	-0.016700	-6.16e-02	9.02e-01	6.51e-01
Apoptosis	152	8.29e-01	8.80e-01	0.01420	-0.013700	3.72e-03	7.70e-01	9.37e-01
Repression-of-WNT-target-genes	14	8.34e-01	8.84e-01	0.12200	0.092800	7.92e-02	5.48e-01	6.08e-01
Insertion-of-tail-anchored-proteins-into-the-endoplasmic-reticulum-membrane	19	8.38e-01	8.88e-01	0.09930	0.060800	7.85e-02	6.47e-01	5.53e-01
Processing-and-activation-of-SUMO	10	8.40e-01	8.89e-01	0.06910	0.068700	6.97e-03	7.07e-01	9.70e-01
Uptake-and-function-of-anthrax-toxins	10	8.41e-01	8.89e-01	0.09150	-0.031700	-8.58e-02	8.62e-01	6.38e-01
MAP3K8-(TPL2)-dependent-MAPK1/3-activation	16	8.48e-01	8.96e-01	0.08790	0.076500	4.32e-02	5.96e-01	7.65e-01
G-alpha-(q)-signalling-events	118	8.50e-01	8.97e-01	0.04050	0.027200	3.00e-02	6.10e-01	5.74e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-1-Promoter	26	8.52e-01	8.98e-01	0.08520	-0.063400	-5.69e-02	5.76e-01	6.16e-01
Glutathione-synthesis-and-recycling	10	8.53e-01	8.98e-01	0.06980	0.010900	6.89e-02	9.52e-01	7.06e-01
Early-Phase-of-HIV-Life-Cycle	11	8.53e-01	8.98e-01	0.08700	-0.080700	-3.26e-02	6.43e-01	8.51e-01
DNA-Damage/Telomere-Stress-Induced-Senescence	25	8.55e-01	8.99e-01	0.08430	0.064700	5.41e-02	5.76e-01	6.40e-01
Activation-of-AMPK-downstream-of-NMDARs	10	8.56e-01	9.00e-01	0.04910	0.015100	-4.68e-02	9.34e-01	7.98e-01
SUMOylation-of-DNA-replication-proteins	45	8.60e-01	9.01e-01	0.02240	0.020900	-8.05e-03	8.09e-01	9.26e-01
Antigen-Presentation:-Folding,-assembly-and-peptide-loading-of-class-I-MHC	16	8.60e-01	9.01e-01	0.07950	-0.036200	-7.08e-02	8.02e-01	6.24e-01
Cholesterol-biosynthesis	23	8.60e-01	9.01e-01	0.08560	-0.054300	-6.61e-02	6.52e-01	5.83e-01
Regulation-of-TP53-Activity-through-Acetylation	28	8.61e-01	9.01e-01	0.06290	-0.030600	-5.49e-02	7.79e-01	6.15e-01
Cooperation-of-PDCL-(PhLP1)-and-TRiC/CCT-in-G-protein-beta-folding	31	8.61e-01	9.01e-01	0.07370	0.047000	5.68e-02	6.50e-01	5.85e-01
Negative-regulation-of-MAPK-pathway	38	8.69e-01	9.08e-01	0.06700	-0.047500	-4.72e-02	6.12e-01	6.15e-01
Erythropoietin-activates-RAS	13	8.69e-01	9.08e-01	0.03800	0.019500	-3.27e-02	9.03e-01	8.38e-01
Translocation-of-SLC2A4-(GLUT4)-to-the-plasma-membrane	51	8.70e-01	9.09e-01	0.04950	-0.027200	-4.13e-02	7.37e-01	6.10e-01
AKT-phosphorylates-targets-in-the-cytosol	14	8.71e-01	9.09e-01	0.06140	-0.015700	-5.94e-02	9.19e-01	7.01e-01
Fatty-acyl-CoA-biosynthesis	28	8.78e-01	9.16e-01	0.07120	-0.044500	-5.56e-02	6.84e-01	6.11e-01
Recognition-of-DNA-damage-by-PCNA-containing-replication-complex	29	8.82e-01	9.19e-01	0.02650	-0.025600	7.04e-03	8.12e-01	9.48e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-3-Promoter	26	8.83e-01	9.19e-01	0.02500	-0.014300	2.05e-02	9.00e-01	8.57e-01
ERKs-are-inactivated	12	8.90e-01	9.25e-01	0.06800	-0.023100	-6.40e-02	8.90e-01	7.01e-01
Activation-of-G-protein-gated-Potassium-channels	15	8.92e-01	9.25e-01	0.06980	-0.030700	-6.27e-02	8.37e-01	6.74e-01
G-protein-gated-Potassium-channels	15	8.92e-01	9.25e-01	0.06980	-0.030700	-6.27e-02	8.37e-01	6.74e-01
Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits	15	8.92e-01	9.25e-01	0.06980	-0.030700	-6.27e-02	8.37e-01	6.74e-01
RHO-GTPases-activate-IQGAPs	10	8.93e-01	9.25e-01	0.08810	0.078100	4.07e-02	6.69e-01	8.24e-01
Mitotic-Metaphase-and-Anaphase	165	8.98e-01	9.29e-01	0.02610	0.020900	1.56e-02	6.44e-01	7.30e-01
Signaling-by-NOTCH	164	8.98e-01	9.29e-01	0.02560	-0.020800	-1.50e-02	6.46e-01	7.41e-01
Purine-salvage	11	8.98e-01	9.29e-01	0.06860	-0.023600	-6.44e-02	8.92e-01	7.12e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest	17	9.01e-01	9.31e-01	0.08440	0.063700	5.53e-02	6.49e-01	6.93e-01
Netrin-1-signaling	39	9.05e-01	9.34e-01	0.02360	-0.023600	8.40e-04	7.99e-01	9.93e-01
FCERI-mediated-Ca+2-mobilization	26	9.05e-01	9.34e-01	0.06720	0.044800	5.00e-02	6.92e-01	6.59e-01
Chaperone-Mediated-Autophagy	14	9.06e-01	9.34e-01	0.06580	-0.059500	-2.81e-02	7.00e-01	8.56e-01
Inhibition-of-replication-initiation-of-damaged-DNA-by-RB1/E2F1	13	9.08e-01	9.35e-01	0.09090	0.057500	7.04e-02	7.20e-01	6.60e-01
RNA-Polymerase-III-Chain-Elongation	16	9.13e-01	9.39e-01	0.07140	-0.059600	-3.93e-02	6.80e-01	7.85e-01
Mitotic-Anaphase	164	9.14e-01	9.39e-01	0.02340	0.019000	1.36e-02	6.75e-01	7.65e-01
Downstream-signal-transduction	28	9.15e-01	9.40e-01	0.05670	0.033500	4.57e-02	7.59e-01	6.76e-01
IRS-mediated-signalling	34	9.21e-01	9.46e-01	0.03910	0.035100	1.71e-02	7.23e-01	8.63e-01
Separation-of-Sister-Chromatids	154	9.23e-01	9.46e-01	0.02040	0.010400	1.76e-02	8.24e-01	7.07e-01
Positive-epigenetic-regulation-of-rRNA-expression	46	9.24e-01	9.47e-01	0.02580	-0.024900	-6.71e-03	7.70e-01	9.37e-01
Regulation-of-beta-cell-development	19	9.25e-01	9.47e-01	0.06420	0.051900	3.78e-02	6.95e-01	7.75e-01
rRNA-processing-in-the-nucleus-and-cytosol	156	9.28e-01	9.50e-01	0.01920	0.009540	1.66e-02	8.37e-01	7.20e-01
Regulation-of-IFNG-signaling	13	9.30e-01	9.51e-01	0.07930	-0.051000	-6.08e-02	7.50e-01	7.04e-01
NOTCH4-Intracellular-Domain-Regulates-Transcription	18	9.32e-01	9.52e-01	0.06750	0.044500	5.08e-02	7.44e-01	7.09e-01
Ca-dependent-events	32	9.35e-01	9.54e-01	0.02010	0.019900	-2.53e-03	8.45e-01	9.80e-01
PI3K-Cascade	30	9.35e-01	9.54e-01	0.05160	0.038000	3.49e-02	7.19e-01	7.41e-01
Synthesis-of-very-long-chain-fatty-acyl-CoAs	18	9.48e-01	9.65e-01	0.04890	0.025000	4.20e-02	8.54e-01	7.58e-01
Cleavage-of-the-damaged-pyrimidine	15	9.49e-01	9.65e-01	0.06110	0.037500	4.82e-02	8.01e-01	7.47e-01
Depyrimidination	15	9.49e-01	9.65e-01	0.06110	0.037500	4.82e-02	8.01e-01	7.47e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-pyrimidine	15	9.49e-01	9.65e-01	0.06110	0.037500	4.82e-02	8.01e-01	7.47e-01
p38MAPK-events	12	9.50e-01	9.65e-01	0.02460	0.010500	-2.23e-02	9.50e-01	8.94e-01
Programmed-Cell-Death	155	9.53e-01	9.68e-01	0.00777	-0.000879	7.72e-03	9.85e-01	8.69e-01
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol	147	9.54e-01	9.68e-01	0.01350	0.005440	1.24e-02	9.09e-01	7.96e-01
RNA-Polymerase-III-Transcription-Initiation	34	9.55e-01	9.68e-01	0.03990	-0.026300	-3.00e-02	7.91e-01	7.63e-01
CD209-(DC-SIGN)-signaling	18	9.56e-01	9.68e-01	0.04090	-0.018600	-3.64e-02	8.91e-01	7.89e-01
Initial-triggering-of-complement	11	9.59e-01	9.71e-01	0.03150	0.031400	2.45e-03	8.57e-01	9.89e-01
CaM-pathway	30	9.64e-01	9.73e-01	0.01250	0.008680	-9.04e-03	9.34e-01	9.32e-01
Calmodulin-induced-events	30	9.64e-01	9.73e-01	0.01250	0.008680	-9.04e-03	9.34e-01	9.32e-01
Spry-regulation-of-FGF-signaling	16	9.66e-01	9.75e-01	0.03920	-0.018500	-3.46e-02	8.98e-01	8.11e-01
Opioid-Signalling	72	9.68e-01	9.76e-01	0.00783	0.003990	-6.74e-03	9.53e-01	9.21e-01
Diseases-of-carbohydrate-metabolism	29	9.74e-01	9.82e-01	0.03280	0.024000	2.24e-02	8.23e-01	8.35e-01
NOTCH2-Activation-and-Transmission-of-Signal-to-the-Nucleus	21	9.75e-01	9.82e-01	0.01900	0.018900	2.71e-03	8.81e-01	9.83e-01
FGFR1-mutant-receptor-activation	25	9.76e-01	9.82e-01	0.01630	-0.001540	-1.63e-02	9.89e-01	8.88e-01
Formation-of-the-beta-catenin:TCF-transactivating-complex	31	9.77e-01	9.82e-01	0.02670	0.021900	1.52e-02	8.33e-01	8.83e-01
MECP2-regulates-neuronal-receptors-and-channels	12	9.78e-01	9.82e-01	0.02400	0.023700	3.68e-03	8.87e-01	9.82e-01
PKMTs-methylate-histone-lysines	42	9.81e-01	9.85e-01	0.02100	-0.017300	-1.21e-02	8.47e-01	8.92e-01
HuR-(ELAVL1)-binds-and-stabilizes-mRNA	10	9.86e-01	9.89e-01	0.03100	-0.027300	-1.46e-02	8.81e-01	9.36e-01
Glucagon-like-Peptide-1-(GLP1)-regulates-insulin-secretion	31	9.87e-01	9.89e-01	0.01040	0.000508	1.04e-02	9.96e-01	9.20e-01
NOD1/2-Signaling-Pathway	28	9.91e-01	9.93e-01	0.00721	0.001710	-7.00e-03	9.87e-01	9.49e-01
Inactivation,-recovery-and-regulation-of-the-phototransduction-cascade	17	9.97e-01	9.97e-01	0.01260	-0.010400	-7.04e-03	9.41e-01	9.60e-01
The-phototransduction-cascade	17	9.97e-01	9.97e-01	0.01260	-0.010400	-7.04e-03	9.41e-01	9.60e-01

---

Detailed Gene set reports

The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport

The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport

metric	value
setSize	167
pMANOVA	1.25e-82
p.adjustMANOVA	1.6e-79
s.dist	1.17
s.young	-0.835
s.old	-0.813
p.young	5.14e-78
p.old	5.46e-74

Top 20 genes

Gene	young	old
Adhfe1	-7349	-7821
Ldhb	-7348	-7811
Sdha	-7346	-7813
Ndufb8	-7343	-7800
Atp5o	-7347	-7794
Sdhd	-7333	-7791
Etfa	-7323	-7764
Etfdh	-7269	-7789
Ndufc2	-7325	-7719
Ndufa9	-7317	-7720
Atp5l	-7340	-7690
Uqcr11	-7327	-7657
Sucla2	-7292	-7689
Mpc2	-7294	-7670
Ndufv2	-7260	-7683
Suclg2	-7193	-7724
Uqcrfs1	-7311	-7599
Idh3b	-7322	-7586
Dld	-7216	-7696
Uqcrh	-7334	-7571

Click HERE to show all gene set members

All member genes

	young	old
Acad9	-6612	-6647
Aco2	-6436	-6977
Adhfe1	-7349	-7821
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Atp5c1	-7207	-7515
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5g3	-7235	-7573
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5j2	-7093	-7135
Atp5k	-5830	-7288
Atp5l	-7340	-7690
Atp5o	-7347	-7794
Atp5pb	-7213	-7607
Bsg	-6548	-7267
Coq10a	-7209	-7269
Coq10b	-5270	-2925
Cox11	-4941	-6003
Cox14	-7095	-6340
Cox16	-5100	-3654
Cox18	-4863	-4177
Cox19	6674	6213
Cox20	-4854	-5240
Cox4i1	-7272	-7222
Cox5a	-7164	-7617
Cox5b	-6986	-7126
Cox6a1	-5249	-3806
Cox6b1	-7136	-6612
Cox6c	-7114	-7331
Cox7a2l	-6270	-6466
Cox7b	-7084	-7330
Cox7c	-6438	-7237
Cox8a	-3627	-1367
Cs	-7238	-7580
Cyc1	-7237	-7220
Cycs	-7133	-7302
D2hgdh	-7104	-7565
Dlat	-7003	-7332
Dld	-7216	-7696
Dlst	-7165	-7693
Dmac2l	-6520	-7171
Ecsit	-6908	-6444
Etfa	-7323	-7764
Etfb	-7336	-7558
Etfdh	-7269	-7789
Fahd1	-7052	-7556
Fh1	-7115	-7449
Glo1	-5689	-5454
Gstz1	-6066	-6846
Hagh	3129	-1329
Idh2	-6961	-7381
Idh3a	-7085	-7634
Idh3b	-7322	-7586
Idh3g	-7228	-7314
L2hgdh	-6879	-7484
Ldha	3559	-4312
Ldhb	-7348	-7811
Lrpprc	-7024	-7746
Mdh2	-7233	-7179
Me1	-6765	-6942
Me2	5856	4582
Me3	-7147	-7472
Mpc1	-7043	-7036
Mpc2	-7294	-7670
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
mt-Co1	-7257	-7632
mt-Co2	-7163	-6523
mt-Co3	-7307	-7023
mt-Cytb	-6947	-7620
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd5	-6386	-7564
mt-Nd6	-6677	-7251
Ndufa1	-5430	-6709
Ndufa10	-7288	-7572
Ndufa11	-7330	-7448
Ndufa12	-7240	-7308
Ndufa13	-7053	-7089
Ndufa2	-6895	-6030
Ndufa3	-7000	-7510
Ndufa4	-7274	-7232
Ndufa5	-7189	-7647
Ndufa6	-6698	-7117
Ndufa7	-7328	-7459
Ndufa8	-7315	-7154
Ndufa9	-7317	-7720
Ndufab1	-7247	-7579
Ndufaf1	-7011	-7559
Ndufaf2	-4758	-5261
Ndufaf3	-4910	-5440
Ndufaf4	-6419	-7254
Ndufaf5	-5750	-6463
Ndufaf6	-6271	-7083
Ndufaf7	-5738	-6678
Ndufb1-ps	-5319	-6906
Ndufb10	-7199	-7209
Ndufb2	-7214	-7114
Ndufb3	-6549	-6607
Ndufb4	-7132	-7245
Ndufb5	-7181	-6935
Ndufb6	-6950	-7112
Ndufb7	-7225	-6331
Ndufb8	-7343	-7800
Ndufb9	-7140	-7223
Ndufc1	-6951	-7311
Ndufc2	-7325	-7719
Ndufs1	-7157	-7633
Ndufs2	-7314	-7534
Ndufs3	-7291	-7530
Ndufs4	-7275	-7583
Ndufs5	-7010	-7087
Ndufs6	-7098	-7550
Ndufs7	-7258	-6981
Ndufs8	-7303	-7304
Ndufv1	-7186	-6904
Ndufv2	-7260	-7683
Ndufv3	-7034	-7419
Nnt	-6917	-7798
Nubpl	-6153	-6907
Ogdh	-7013	-7475
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Pdk1	4156	-6364
Pdk2	-6889	-7055
Pdk3	6805	6440
Pdk4	-1655	1645
Pdp1	-4181	-5275
Pdp2	-5917	-7570
Pdpr	-5996	-7506
Ppard	-5588	-4490
Rxra	-6194	-6804
Sco1	-6462	-6322
Sco2	-3709	-4161
Sdha	-7346	-7813
Sdhb	-7295	-7485
Sdhc	-7227	-7405
Sdhd	-7333	-7791
Slc16a1	-5936	-4200
Slc16a3	7305	6044
Slc16a8	-4482	-3791
Slc25a14	4008	2705
Slc25a27	1019	1297
Sucla2	-7292	-7689
Suclg1	-7259	-7645
Suclg2	-7193	-7724
Surf1	-5087	-5645
Taco1	-6970	-7208
Timmdc1	-6360	-5463
Tmem126b	-5883	-7021
Trap1	-6975	-6844
Ucp2	-3935	3288
Ucp3	-3606	-5388
Uqcr10	-6171	-4525
Uqcr11	-7327	-7657
Uqcrb	-6857	-7389
Uqcrc1	-7297	-7415
Uqcrc2	-7191	-7618
Uqcrfs1	-7311	-7599
Uqcrh	-7334	-7571
Uqcrq	-7158	-7033
Vdac1	-7008	-7195

---

---

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

metric	value
setSize	120
pMANOVA	4.61e-65
p.adjustMANOVA	2.95e-62
s.dist	1.22
s.young	-0.883
s.old	-0.836
p.young	5.28e-63
p.old	1.12e-56

Top 20 genes

Gene	young	old
Sdha	-7346	-7813
Ndufb8	-7343	-7800
Atp5o	-7347	-7794
Sdhd	-7333	-7791
Etfa	-7323	-7764
Etfdh	-7269	-7789
Ndufc2	-7325	-7719
Ndufa9	-7317	-7720
Atp5l	-7340	-7690
Uqcr11	-7327	-7657
Ndufv2	-7260	-7683
Uqcrfs1	-7311	-7599
Uqcrh	-7334	-7571
Etfb	-7336	-7558
mt-Co1	-7257	-7632
Ndufa10	-7288	-7572
Ndufs4	-7275	-7583
Ndufs2	-7314	-7534
Ndufa5	-7189	-7647
Ndufab1	-7247	-7579

Click HERE to show all gene set members

All member genes

	young	old
Acad9	-6612	-6647
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Atp5c1	-7207	-7515
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5g3	-7235	-7573
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5j2	-7093	-7135
Atp5k	-5830	-7288
Atp5l	-7340	-7690
Atp5o	-7347	-7794
Atp5pb	-7213	-7607
Coq10a	-7209	-7269
Coq10b	-5270	-2925
Cox11	-4941	-6003
Cox14	-7095	-6340
Cox16	-5100	-3654
Cox18	-4863	-4177
Cox19	6674	6213
Cox20	-4854	-5240
Cox4i1	-7272	-7222
Cox5a	-7164	-7617
Cox5b	-6986	-7126
Cox6a1	-5249	-3806
Cox6b1	-7136	-6612
Cox6c	-7114	-7331
Cox7a2l	-6270	-6466
Cox7b	-7084	-7330
Cox7c	-6438	-7237
Cox8a	-3627	-1367
Cyc1	-7237	-7220
Cycs	-7133	-7302
Dmac2l	-6520	-7171
Ecsit	-6908	-6444
Etfa	-7323	-7764
Etfb	-7336	-7558
Etfdh	-7269	-7789
Lrpprc	-7024	-7746
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
mt-Co1	-7257	-7632
mt-Co2	-7163	-6523
mt-Co3	-7307	-7023
mt-Cytb	-6947	-7620
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd5	-6386	-7564
mt-Nd6	-6677	-7251
Ndufa1	-5430	-6709
Ndufa10	-7288	-7572
Ndufa11	-7330	-7448
Ndufa12	-7240	-7308
Ndufa13	-7053	-7089
Ndufa2	-6895	-6030
Ndufa3	-7000	-7510
Ndufa4	-7274	-7232
Ndufa5	-7189	-7647
Ndufa6	-6698	-7117
Ndufa7	-7328	-7459
Ndufa8	-7315	-7154
Ndufa9	-7317	-7720
Ndufab1	-7247	-7579
Ndufaf1	-7011	-7559
Ndufaf2	-4758	-5261
Ndufaf3	-4910	-5440
Ndufaf4	-6419	-7254
Ndufaf5	-5750	-6463
Ndufaf6	-6271	-7083
Ndufaf7	-5738	-6678
Ndufb1-ps	-5319	-6906
Ndufb10	-7199	-7209
Ndufb2	-7214	-7114
Ndufb3	-6549	-6607
Ndufb4	-7132	-7245
Ndufb5	-7181	-6935
Ndufb6	-6950	-7112
Ndufb7	-7225	-6331
Ndufb8	-7343	-7800
Ndufb9	-7140	-7223
Ndufc1	-6951	-7311
Ndufc2	-7325	-7719
Ndufs1	-7157	-7633
Ndufs2	-7314	-7534
Ndufs3	-7291	-7530
Ndufs4	-7275	-7583
Ndufs5	-7010	-7087
Ndufs6	-7098	-7550
Ndufs7	-7258	-6981
Ndufs8	-7303	-7304
Ndufv1	-7186	-6904
Ndufv2	-7260	-7683
Ndufv3	-7034	-7419
Nubpl	-6153	-6907
Sco1	-6462	-6322
Sco2	-3709	-4161
Sdha	-7346	-7813
Sdhb	-7295	-7485
Sdhc	-7227	-7405
Sdhd	-7333	-7791
Slc25a14	4008	2705
Slc25a27	1019	1297
Surf1	-5087	-5645
Taco1	-6970	-7208
Timmdc1	-6360	-5463
Tmem126b	-5883	-7021
Trap1	-6975	-6844
Ucp2	-3935	3288
Ucp3	-3606	-5388
Uqcr10	-6171	-4525
Uqcr11	-7327	-7657
Uqcrb	-6857	-7389
Uqcrc1	-7297	-7415
Uqcrc2	-7191	-7618
Uqcrfs1	-7311	-7599
Uqcrh	-7334	-7571
Uqcrq	-7158	-7033

---

---

Respiratory-electron-transport

Respiratory-electron-transport

metric	value
setSize	100
pMANOVA	4.63e-57
p.adjustMANOVA	1.97e-54
s.dist	1.25
s.young	-0.904
s.old	-0.859
p.young	2.8e-55
p.old	4.76e-50

Top 20 genes

Gene	young	old
Sdha	-7346	-7813
Ndufb8	-7343	-7800
Sdhd	-7333	-7791
Etfa	-7323	-7764
Etfdh	-7269	-7789
Ndufc2	-7325	-7719
Ndufa9	-7317	-7720
Uqcr11	-7327	-7657
Ndufv2	-7260	-7683
Uqcrfs1	-7311	-7599
Uqcrh	-7334	-7571
Etfb	-7336	-7558
mt-Co1	-7257	-7632
Ndufa10	-7288	-7572
Ndufs4	-7275	-7583
Ndufs2	-7314	-7534
Ndufa5	-7189	-7647
Ndufab1	-7247	-7579
Ndufs3	-7291	-7530
Uqcrc2	-7191	-7618

Click HERE to show all gene set members

All member genes

	young	old
Acad9	-6612	-6647
Coq10a	-7209	-7269
Coq10b	-5270	-2925
Cox11	-4941	-6003
Cox14	-7095	-6340
Cox16	-5100	-3654
Cox18	-4863	-4177
Cox19	6674	6213
Cox20	-4854	-5240
Cox4i1	-7272	-7222
Cox5a	-7164	-7617
Cox5b	-6986	-7126
Cox6a1	-5249	-3806
Cox6b1	-7136	-6612
Cox6c	-7114	-7331
Cox7a2l	-6270	-6466
Cox7b	-7084	-7330
Cox7c	-6438	-7237
Cox8a	-3627	-1367
Cyc1	-7237	-7220
Cycs	-7133	-7302
Ecsit	-6908	-6444
Etfa	-7323	-7764
Etfb	-7336	-7558
Etfdh	-7269	-7789
Lrpprc	-7024	-7746
mt-Co1	-7257	-7632
mt-Co2	-7163	-6523
mt-Co3	-7307	-7023
mt-Cytb	-6947	-7620
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd5	-6386	-7564
mt-Nd6	-6677	-7251
Ndufa1	-5430	-6709
Ndufa10	-7288	-7572
Ndufa11	-7330	-7448
Ndufa12	-7240	-7308
Ndufa13	-7053	-7089
Ndufa2	-6895	-6030
Ndufa3	-7000	-7510
Ndufa4	-7274	-7232
Ndufa5	-7189	-7647
Ndufa6	-6698	-7117
Ndufa7	-7328	-7459
Ndufa8	-7315	-7154
Ndufa9	-7317	-7720
Ndufab1	-7247	-7579
Ndufaf1	-7011	-7559
Ndufaf2	-4758	-5261
Ndufaf3	-4910	-5440
Ndufaf4	-6419	-7254
Ndufaf5	-5750	-6463
Ndufaf6	-6271	-7083
Ndufaf7	-5738	-6678
Ndufb1-ps	-5319	-6906
Ndufb10	-7199	-7209
Ndufb2	-7214	-7114
Ndufb3	-6549	-6607
Ndufb4	-7132	-7245
Ndufb5	-7181	-6935
Ndufb6	-6950	-7112
Ndufb7	-7225	-6331
Ndufb8	-7343	-7800
Ndufb9	-7140	-7223
Ndufc1	-6951	-7311
Ndufc2	-7325	-7719
Ndufs1	-7157	-7633
Ndufs2	-7314	-7534
Ndufs3	-7291	-7530
Ndufs4	-7275	-7583
Ndufs5	-7010	-7087
Ndufs6	-7098	-7550
Ndufs7	-7258	-6981
Ndufs8	-7303	-7304
Ndufv1	-7186	-6904
Ndufv2	-7260	-7683
Ndufv3	-7034	-7419
Nubpl	-6153	-6907
Sco1	-6462	-6322
Sco2	-3709	-4161
Sdha	-7346	-7813
Sdhb	-7295	-7485
Sdhc	-7227	-7405
Sdhd	-7333	-7791
Surf1	-5087	-5645
Taco1	-6970	-7208
Timmdc1	-6360	-5463
Tmem126b	-5883	-7021
Trap1	-6975	-6844
Uqcr10	-6171	-4525
Uqcr11	-7327	-7657
Uqcrb	-6857	-7389
Uqcrc1	-7297	-7415
Uqcrc2	-7191	-7618
Uqcrfs1	-7311	-7599
Uqcrh	-7334	-7571
Uqcrq	-7158	-7033

---

---

Metabolism

Metabolism

metric	value
setSize	1613
pMANOVA	5.51e-49
p.adjustMANOVA	1.76e-46
s.dist	0.3
s.young	-0.2
s.old	-0.224
p.young	1.76e-39
p.old	2.43e-49

Top 20 genes

Gene	young	old
Adhfe1	-7349	-7821
Ldhb	-7348	-7811
Sdha	-7346	-7813
Bckdha	-7342	-7803
Ndufb8	-7343	-7800
Atp5o	-7347	-7794
Sdhd	-7333	-7791
Fbp2	-7329	-7784
Rpl3l	-7308	-7793
Etfa	-7323	-7764
Hadh	-7309	-7774
Acsl6	-7255	-7818
Acaa2	-7293	-7768
Eci1	-7341	-7716
Hadhb	-7300	-7759
Etfdh	-7269	-7789
Acot2	-7253	-7797
Ndufc2	-7325	-7719
Decr1	-7267	-7777
Ndufa9	-7317	-7720

Click HERE to show all gene set members

All member genes

	young	old
Aaas	-621	4067
Aacs	4302	4629
Aasdhppt	-5332	-6024
Aass	2387	-691
Abca1	5067	-281
Abcb1a	-4791	-6980
Abcb4	7210	6934
Abcb7	-4170	-6013
Abcc1	6729	6819
Abcc3	-27	473
Abcc5	-766	3315
Abcc8	-3063	5569
Abcd1	-6190	-6228
Abcd4	4811	4646
Abhd10	-5446	-5667
Abhd14b	-1058	-3628
Abhd3	-1534	-4787
Abhd4	6723	4307
Abhd5	-5259	-6321
Acaa2	-7293	-7768
Acaca	3453	-653
Acacb	-6936	-7366
Acad11	-7134	-7691
Acad12	-6749	-6851
Acad8	-6496	-7039
Acad9	-6612	-6647
Acadl	-6920	-7478
Acadm	-7198	-7598
Acads	-7280	-7250
Acadsb	-5889	-7297
Acadvl	-7306	-7500
Acat1	-7263	-7711
Acbd4	3015	4544
Acbd5	6712	4401
Acbd6	-5225	-2979
Acer2	3412	-4615
Acer3	-4605	-2376
Ache	2008	-1040
Acly	-3791	-3425
Aco2	-6436	-6977
Acot11	-6459	-7215
Acot13	-7060	-7028
Acot2	-7253	-7797
Acot4	825	-4529
Acot6	3177	-2145
Acot7	-5971	-6960
Acot8	559	-172
Acot9	7045	6582
Acox1	-4724	-7321
Acox3	1630	-3864
Acp6	-6447	-7191
Acsf2	-5910	-7231
Acsf3	-6626	-7575
Acsl1	-6926	-7461
Acsl3	2818	-794
Acsl4	4513	954
Acsl5	3226	5103
Acsl6	-7255	-7818
Acss1	-6305	-7406
Acss2	-2290	-928
Acss3	-6033	-5191
Acy1	-6769	-7455
Acy3	-5853	-6710
Ada	5174	1816
Adal	-4577	-4407
Adcy1	-6563	-7364
Adcy2	5556	5860
Adcy3	4131	2305
Adcy4	-5866	-4935
Adcy5	2555	4612
Adcy6	-5219	-4103
Adcy7	7472	6866
Adcy9	-4881	-5347
Adh1	-6458	-7736
Adh5	-6016	-6729
Adhfe1	-7349	-7821
Adi1	-7100	-7626
Adipor1	-5064	-2432
Adipor2	-5964	-6625
Adk	-7239	-7666
Ado	23	-3026
Adpgk	4874	6241
Adprm	-3014	-293
Adra2c	-1945	2287
Adsl	-6977	-6230
Afmid	-2177	-5588
Agk	-4625	-6343
Agl	-6450	-7289
Agmo	3384	5619
Agpat1	-4882	-3988
Agpat2	-6388	-6657
Agpat3	-6640	-7071
Agpat4	4662	6089
Agpat5	-6415	-5448
Agps	-605	-2899
Agrn	-247	199
Agt	-4320	-6233
Ahcyl1	366	-4646
Ahr	-4294	-7324
Ahrr	-6799	-7285
Aimp1	-2872	-3408
Aimp2	-1669	2875
Aip	1548	2004
Ak1	-6948	-6467
Ak2	-4753	-4622
Ak4	-5052	-7686
Akap5	-5903	-5346
Akr1a1	4454	2681
Akr1b3	-6803	-6959
Akr1b8	6176	5778
Akr7a5	-6955	-6221
Akt1	-6210	-5765
Alad	-6408	-7246
Alas1	-6613	-7012
Alas2	-622	-3401
Alb	-2631	1215
Aldh18a1	6276	3540
Aldh1b1	-6065	-5168
Aldh1l1	3338	-5483
Aldh1l2	-6464	-7458
Aldh2	-7079	-7142
Aldh3a1	888	4513
Aldh3a2	-30	-948
Aldh3b1	2547	2932
Aldh4a1	-7153	-7436
Aldh6a1	-6998	-7778
Aldh7a1	340	-5395
Aldh9a1	-3846	-6971
Aldoa	-6760	-6877
Aldob	-4396	-1794
Alox12	-652	-4906
Alox5	-6090	-7663
Alox5ap	925	-623
Alox8	-2406	3609
Amacr	-6767	-7086
Amd2	-4381	-1651
Ampd2	5875	5359
Ampd3	-40	932
Amt	-5168	1070
Angptl4	302	-3528
Ankrd1	7476	6925
Aoc2	-982	2100
Aoc3	2984	-4451
Aox1	-3568	-5873
Apip	-6666	-7349
Apoa1	-3117	-370
Apoa2	-4104	-1788
Apob	-2312	1254
Apoe	948	-334
Aprt	3957	4574
Arf1	-59	-3518
Arf3	6868	5063
Arnt	5880	5777
Arnt2	3608	3095
Arntl	4182	-1853
Arsa	3605	-897
Arsb	6684	5613
Arsg	5743	5658
Arsi	-5136	-5584
Arsj	-449	-2677
Arsk	5442	4251
Arv1	-108	210
As3mt	-6987	-7385
Asah1	6043	3973
Asah2	1176	-4555
Asl	7069	6794
Asns	4991	912
Aspa	530	1151
Asrgl1	-5841	-3768
Ass1	4425	5786
Atic	5874	4472
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Atp5c1	-7207	-7515
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5g3	-7235	-7573
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5j2	-7093	-7135
Atp5k	-5830	-7288
Atp5l	-7340	-7690
Atp5o	-7347	-7794
Atp5pb	-7213	-7607
Auh	-6904	-7596
Azin1	7005	6713
Azin2	5514	5956
B3galnt1	5778	2318
B3galt1	5246	6656
B3galt2	6942	6534
B3galt4	3003	4149
B3galt6	4154	3582
B3gat2	2242	2141
B3gat3	-677	-1460
B3gnt2	6711	5903
B3gnt3	-5788	-6546
B4galnt1	5962	6221
B4galt1	3267	1068
B4galt2	6315	4664
B4galt3	-4310	-1405
B4galt4	-4249	-652
B4galt5	6407	5561
B4galt6	6036	6103
B4galt7	-1177	-3787
Bcat1	4700	5242
Bcat2	-6905	-7609
Bche	5266	6487
Bckdha	-7342	-7803
Bckdhb	-6907	-7611
Bckdk	-6679	-6373
Bdh1	7034	-1618
Bdh2	-195	-88
Bgn	7481	6830
Bhmt	-2632	2010
Blvra	471	-3448
Blvrb	1034	-3807
Bmx	5463	1734
Bpgm	-2698	-3560
Bphl	-6195	-6442
Bpnt1	-5976	-4937
Brip1	1464	3982
Bsg	-6548	-7267
Bst1	3734	939
Btd	5564	5009
Cacna1a	-3426	5118
Cacna1c	-3035	-6072
Cacna1d	-368	-2755
Cacna1e	3836	2997
Cacna2d2	-232	3850
Cacnb2	-5371	-6792
Cacnb3	6991	5679
Cad	2201	-3514
Calm1	-4595	-4970
Car13	-613	1473
Car14	-7076	-7760
Car2	-499	-6135
Car3	-1211	-3426
Car4	-6160	-7244
Car5b	2656	3024
Car7	-2190	-4233
Car9	6540	6683
Carm1	-1701	-5594
Carnmt1	-7017	-6894
Carns1	-4558	-4571
Cav1	-5892	-7143
Cbr1	-5186	-6178
Cbr3	4810	4342
Cbr4	-6830	-7226
Cbs	-35	2170
Ccnc	3190	2238
Cd320	-4968	-5750
Cd36	-5986	-7614
Cd38	993	-2160
Cd44	7295	7013
Cda	4564	6277
Cdipt	-1066	1943
Cdk19	2454	4015
Cdk8	6754	5462
Cdo1	-2028	-1915
Cds1	4034	-6561
Cds2	-4274	-3035
Cemip	3758	3579
Cept1	-4667	-4738
Cerk	1237	-682
Cers2	4517	5812
Cers4	775	433
Cers5	985	4266
Cers6	7092	3598
Ch25h	4808	3678
Chac1	-1375	1431
Chac2	-5477	-6884
Chd9	6475	5594
Chka	4684	3845
Chkb	-6441	-7178
Chp1	-1311	-5595
Chpf	7328	5652
Chpf2	6949	6362
Chpt1	-7142	-6809
Chrm3	225	-2399
Chst1	1851	-809
Chst11	1137	4315
Chst12	4324	4171
Chst14	5647	3716
Chst15	-359	-4584
Chst2	1230	685
Chst3	6451	6127
Chst7	1335	-705
Chsy1	7110	5672
Chsy3	6387	6260
Ciao1	-3511	-3144
Ciao2b	3162	2235
Ciao3	-6342	-5446
Ciapin1	-6316	-6818
Cidea	837	295
Ckb	7244	4926
Ckm	-7215	-7641
Ckmt2	-7223	-7479
Clock	2389	-3620
Cmbl	-6319	-5572
Cmpk1	6132	946
Cndp2	4741	-946
Coasy	-5208	-5639
Comt	2076	4068
Coq10a	-7209	-7269
Coq10b	-5270	-2925
Coq2	-7039	-7275
Coq3	-6915	-7413
Coq5	-7232	-7551
Coq6	-7111	-7345
Coq7	-6572	-6603
Coq9	-7305	-7450
Cox10	-7063	-7211
Cox11	-4941	-6003
Cox14	-7095	-6340
Cox16	-5100	-3654
Cox18	-4863	-4177
Cox19	6674	6213
Cox20	-4854	-5240
Cox4i1	-7272	-7222
Cox5a	-7164	-7617
Cox5b	-6986	-7126
Cox6a1	-5249	-3806
Cox6b1	-7136	-6612
Cox6c	-7114	-7331
Cox7a2l	-6270	-6466
Cox7b	-7084	-7330
Cox7c	-6438	-7237
Cox8a	-3627	-1367
Cpne1	5193	4338
Cpne3	568	-3635
Cpne7	4472	1723
Cpox	-4331	-6386
Cps1	-3405	1717
Cpt1a	3375	-3304
Cpt1b	-6751	-7032
Cpt2	-7007	-7546
Cptp	-650	-1108
Crat	-7321	-7591
Crebbp	-3332	-3533
Crls1	-2528	-6363
Crot	-1116	-3382
Cryl1	1395	-2308
Cs	-7238	-7580
Csad	6740	-92
Csgalnact1	2042	-2352
Csgalnact2	6411	5972
Csnk1g2	-1867	-1025
Csnk2a1	-6837	-7714
Csnk2a2	2827	-156
Csnk2b	-4627	-5569
Cspg4	7500	6779
Cspg5	-3048	1942
Ctps	-880	-3797
Ctps2	2846	3943
Ctsa	3546	448
Cubn	-5532	-3322
Cyb5a	4661	2737
Cyb5b	-3095	-5778
Cyb5r3	7460	6850
Cyc1	-7237	-7220
Cycs	-7133	-7302
Cygb	6925	6051
Cyp1b1	7393	6028
Cyp26b1	-5413	-5234
Cyp27a1	4250	3986
Cyp2e1	-5364	1158
Cyp2r1	2096	2307
Cyp2s1	5484	5357
Cyp2u1	-6251	-6620
Cyp39a1	5373	3249
Cyp3a13	-7338	-6252
Cyp46a1	3175	2449
Cyp4b1	-6994	-6671
Cyp4f17	2111	2302
Cyp4v3	1947	2922
Cyp51	1692	-4686
Cyp7b1	-361	-1822
D2hgdh	-7104	-7565
Dbh	-7033	-5268
Dbi	-6324	-6808
Dbt	-6615	-7756
Dck	3571	2747
Dcn	7414	6701
Dct	-827	-752
Dctd	1948	-1237
Dctpp1	-6036	-5416
Dcxr	-3853	-4216
Ddah1	7167	6125
Ddah2	5362	5358
Ddc	4170	2144
Ddhd1	6916	6717
Ddhd2	3184	-3909
Ddo	-5929	-5213
Decr1	-7267	-7777
Decr2	-2640	-3902
Degs2	-1416	993
Dera	5642	2254
Dgat1	-4190	-4756
Dgat2	-7202	-7707
Dguok	-5826	-6315
Dhcr24	2696	5785
Dhcr7	-1331	-2195
Dhfr	3475	-3357
Dhodh	-6573	-6194
Dhrs7b	701	2189
Dhtkd1	-4047	-5919
Dio2	7388	6999
Dlat	-7003	-7332
Dld	-7216	-7696
Dlst	-7165	-7693
Dmac2l	-6520	-7171
Dnm2	-4130	324
Dnph1	-2380	-1399
Dpep1	6542	-2015
Dpep2	2183	4844
Dpyd	-6108	-7600
Dse	7298	6706
Dsel	7222	6720
Dtymk	963	1436
Duox1	-6105	-6117
Duox2	-637	2294
Dut	-6277	-6663
Ebp	-4138	3561
Echs1	-7313	-7662
Eci1	-7341	-7716
Ecsit	-6908	-6444
Eef1e1	-4012	130
Eefsec	1269	951
Ehhadh	-5758	-7027
Elovl1	5112	5663
Elovl5	-3997	-5603
Elovl6	3634	2877
Elovl7	4758	-245
Eno2	5951	5994
Eno3	-7068	-7520
Enoph1	1804	-600
Enpp1	7412	6989
Enpp2	-6341	-7019
Enpp3	-1951	1359
Enpp6	7214	5995
Entpd1	5390	4734
Entpd2	3179	4833
Entpd4	-6245	-5953
Entpd5	-7071	-7638
Entpd6	-6808	-6766
Entpd7	6028	5286
Ep300	-2809	-454
Ephx1	5852	6322
Ephx2	-6954	-7595
Epm2a	-3265	-4231
Ercc2	-3616	-1854
Esd	5885	6236
Esrra	-6804	-5371
Esyt1	4773	5394
Esyt2	4137	4086
Etfa	-7323	-7764
Etfb	-7336	-7558
Etfdh	-7269	-7789
Ethe1	-6340	-6782
Etnk1	-4063	-5539
Etnk2	-2993	2158
Ext1	6621	6756
Ext2	1986	-1619
Faah	5123	5120
Fabp3	-5416	-6575
Fabp4	-2511	-7146
Fabp5	-285	-5130
Fads1	6269	5837
Fads2	6205	6018
Fah	-3841	-7452
Fahd1	-7052	-7556
Fam120b	-1758	590
Far1	5654	4954
Far2	-356	2061
Fasn	4789	4808
Fau	519	-1304
Fbp2	-7329	-7784
Fdft1	-6800	-7660
Fdps	-3157	-4647
Fdx1	-6618	-6735
Fech	-5630	-7325
Fh1	-7115	-7449
Fhl2	-6336	-6536
Fig4	-5247	-5014
Fitm1	-7108	-6932
Fitm2	-6960	-7139
Flad1	-6729	-6342
Flvcr1	-1608	-2467
Fmo1	-3573	1823
Fmo2	1530	4884
Fmod	6247	6867
Folr2	-5324	-4446
Fpgs	3615	-12
Fut10	5116	3585
Fut11	5665	5481
Fut4	107	-1713
Fxn	-6784	-6569
G0s2	-6461	-6515
G6pc3	-4978	-4611
Gaa	-6181	-3586
Galc	5330	5745
Gale	1824	-444
Galk1	4677	1161
Galt	-5538	-5861
Gamt	2034	-2938
Gapdhs	-2761	375
Gart	-4184	-4191
Gatm	5165	1213
Gba	6569	5896
Gba2	-5912	-4220
Gbe1	1051	2417
Gc	-2575	2559
Gcat	-3565	-6828
Gcdh	-7112	-7726
Gch1	-5671	58
Gchfr	-5040	-6739
Gck	6897	4422
Gclc	3359	5552
Gclm	2427	2372
Gcsh	-4256	-7388
Gda	-4999	-5846
Gde1	1830	1866
Gdpd1	-5391	-5869
Gdpd3	-300	692
Gdpd5	-6257	-7242
Ggct	-4419	3751
Ggps1	1607	787
Ggt5	-2340	-6497
Ggt7	5357	4850
Gla	4660	3638
Glb1	5822	1047
Glb1l	5086	5055
Glce	179	-4014
Gldc	-2462	1585
Glipr1	3778	4062
Glo1	-5689	-5454
Glrx	-6526	-5907
Glrx5	-6203	-4666
Gls	761	3611
Gls2	1448	2505
Gltp	3414	115
Glud1	-6306	-7705
Glul	5185	-3734
Glyctk	589	-3235
Gm11808	-5706	-216
Gm20517	4105	-1043
Gm28042	-6038	-5882
Gm2a	4865	2353
Gm49336	3826	3163
Gm50388	-923	1381
Gmpr	-6660	-5971
Gmpr2	920	-1557
Gmps	-4531	-6192
Gna11	-4353	-3900
Gna15	-635	-2576
Gnai1	6499	6092
Gnai2	3854	1841
Gnas	5370	2987
Gnb1	3378	553
Gnb2	2426	-280
Gnb3	-4309	-7248
Gnb4	4703	4055
Gnb5	-739	-4170
Gng10	3588	3127
Gng11	-2381	-3084
Gng12	2443	-1045
Gng2	2834	1842
Gng8	6555	5926
Gngt2	-3723	-2987
Gnmt	-3686	-5324
Gnpat	-7105	-7547
Gnpda1	-60	-2955
Gnpda2	-899	-1019
Gns	-4478	-5630
Got1	-7159	-7522
Got2	-6849	-6590
Gpam	-6358	-7122
Gpat3	-6774	-7555
Gpat4	-1288	-3108
Gpc1	-3801	-4293
Gpc3	2127	-5769
Gpc4	-3619	-6582
Gpc6	6891	6273
Gpcpd1	-5880	-7421
Gpd1	-7040	-7090
Gpd1l	-6427	-6200
Gpd2	-5217	-5433
Gphn	-3470	-5219
Gpi1	729	-2017
Gpihbp1	-3847	-6453
Gps2	-776	1748
Gpt	-6704	-7562
Gpt2	-7080	-7535
Gpx1	6364	6250
Gpx4	-5191	-4638
Grhpr	1747	-5672
Gsr	-2257	-2617
Gss	4249	5167
Gsta3	-5149	195
Gstk1	-7200	-7732
Gstm4	-132	-2249
Gstm5	-4095	-1092
Gstm7	-7077	-6817
Gsto1	3616	410
Gsto2	-2051	-2089
Gstp1	-5950	-3595
Gstt2	-6432	-5965
Gstz1	-6066	-6846
Guk1	-6259	-6154
Gusb	6165	4930
Gyg	7060	6463
Gys1	-6695	-7456
H2-Ke6	-6180	-5754
Hacd1	-4729	1304
Hacd2	4010	-3297
Hacd3	3435	5413
Hacd4	5683	4021
Hadh	-7309	-7774
Hadha	-7254	-7673
Hadhb	-7300	-7759
Hagh	3129	-1329
Has2	3121	-228
Has3	-4602	2169
Hdac3	-6017	-6749
Hdc	4610	3663
Helz2	-4511	2213
Hexa	7315	6493
Hexb	5022	5616
Hibadh	-7283	-7717
Hibch	-6982	-7198
Hilpda	4562	-2593
Hk1	-573	1353
Hk2	-6466	-7376
Hk3	116	-817
Hlcs	3308	3956
Hmbs	-6135	-6468
Hmgcl	-6101	-4870
Hmgcr	2226	985
Hmgcs1	-2407	-6353
Hmgcs2	-7290	-6929
Hmmr	4663	2855
Hmox1	654	381
Hmox2	-6632	-6320
Hnmt	-6197	-7393
Hoga1	-1971	695
Hpgd	4297	-3880
Hpgds	5206	2923
Hprt	3876	1000
Hpse	4346	-2233
Hs2st1	7325	6476
Hs3st1	-493	-13
Hs3st3a1	6472	4761
Hs3st3b1	1722	-4410
Hs6st1	6013	5322
Hs6st2	2526	-4992
Hscb	-1609	-5700
Hsd11b1	4943	-7273
Hsd17b10	-6937	-7410
Hsd17b11	1420	-5712
Hsd17b12	1383	3088
Hsd17b4	-6387	-7282
Hsd17b7	3825	2098
Hsd3b7	132	2489
Hsp90ab1	-3870	-989
Hspg2	6535	3769
Hyal1	4392	6096
Hyal2	2666	4079
Hykk	1262	-3138
Idh1	-3318	-6643
Idh2	-6961	-7381
Idh3a	-7085	-7634
Idh3b	-7322	-7586
Idh3g	-7228	-7314
Idi1	1349	-2423
Ids	6784	4640
Idua	-5121	-5157
Il4i1	414	921
Impa1	3413	3203
Impa2	-6266	-6693
Impad1	4139	-2342
Impdh1	1123	229
Impdh2	-1852	3220
Inmt	4201	-1469
Inpp1	2652	5150
Inpp4a	199	3915
Inpp4b	6154	6206
Inpp5a	-3102	-3476
Inpp5b	1011	-1466
Inpp5d	2237	981
Inpp5e	-5981	-6551
Inpp5f	5077	6043
Inpp5j	6592	6670
Inpp5k	-3478	-3482
Inppl1	-889	4486
Insig1	2500	2552
Insig2	4839	3364
Ip6k1	1885	3022
Ip6k2	5972	5125
Ip6k3	-474	-1178
Ipmk	-4512	-3875
Ippk	3103	3725
Iqgap1	5787	6617
Isca1	-7123	-7445
Isca2	-6619	-6949
Iscu	-5913	-6379
Isyna1	3652	-667
Itpa	-5252	-3744
Itpk1	3657	-468
Itpkb	-6650	-6670
Itpkc	6550	5648
Itpr1	-3696	1181
Itpr2	-1813	4665
Itpr3	-366	4557
Ivd	-7138	-7712
Kars	-1031	-313
Kcnb1	-6567	-5632
Kcnc2	-3247	-1293
Kcng2	-5161	-3474
Kcnj11	-6582	-5269
Kdsr	2324	4456
Khk	-6310	-6917
Kmo	2534	411
Kpnb1	-2201	-4623
Kyat1	-7245	-7312
Kyat3	-5753	-7786
L2hgdh	-6879	-7484
Lbr	-4980	-6539
Lclat1	6246	4683
Ldha	3559	-4312
Ldhb	-7348	-7811
Ldlr	4127	4914
Lgmn	6758	4839
Lhpp	-4463	-2602
Lias	-6337	-6370
Lipe	-4226	-5925
Lipt1	-2499	-5036
Lipt2	-3800	-5935
Lmbrd1	1068	406
Lpcat1	-3107	1624
Lpcat2	3656	4745
Lpcat3	-5695	-6527
Lpcat4	3445	1040
Lpgat1	-3466	-2218
Lpin1	-6854	-7150
Lpin2	3800	2781
Lpin3	5492	6403
Lpl	-6603	-7708
Lrat	-5855	-3045
Lrp1	7439	6377
Lrp10	6104	3421
Lrp12	6686	4703
Lrp8	7444	7007
Lrpprc	-7024	-7746
Lss	3547	3820
Lta4h	5705	4468
Ltc4s	-2697	-1269
Lum	7163	6376
Lypla1	-5039	-3871
Lyve1	-4896	-3254
Man2b1	-3714	-6344
Man2b2	3708	-1097
Man2c1	227	1244
Manba	-640	-2443
Maoa	3098	6466
Maob	-7182	-7755
Mapkapk2	-6622	-6346
Marc2	80	-328
Marcks	5522	3428
Mat1a	-3249	748
Mat2a	-5968	-4190
Mat2b	-4828	-5899
Mboat1	-1674	4442
Mboat2	7144	6699
Mboat7	3123	-1938
Mbtps1	5821	5093
Mbtps2	3160	465
Mcat	-6474	-6636
Mccc1	-6826	-7722
Mccc2	-7174	-7704
Mcee	-7015	-7616
Mdh1	-7059	-7182
Mdh2	-7233	-7179
Me1	-6765	-6942
Me2	5856	4582
Me3	-7147	-7472
Mecr	-6170	-6438
Med1	-2830	-5832
Med10	2803	2486
Med11	5462	1547
Med12	-281	4115
Med13	-2202	-3883
Med13l	-3236	-3463
Med14	461	807
Med15	5138	4459
Med16	-5864	-5683
Med17	797	-2935
Med18	77	-2735
Med19	-2688	-2878
Med21	-4100	-79
Med22	3056	-1594
Med23	-974	-3311
Med24	-1771	-3348
Med25	-3051	-2415
Med26	-5133	-1727
Med27	276	-880
Med28	-3615	-2070
Med29	-5417	-3040
Med30	4570	2236
Med31	-3053	-1604
Med4	-2448	-4093
Med6	2681	-1814
Med7	2798	-1801
Med8	1026	-396
Med9	1506	2554
Mgll	-4506	-7118
Mgst1	-4372	-7368
Mgst3	-7012	-6840
Mid1ip1	-5373	-4247
Miga1	-2284	-1905
Miga2	-6945	-6854
Minpp1	4050	725
Mlx	1324	-586
Mlxipl	-6339	-6284
Mlycd	-6864	-7040
Mmaa	-6691	-6758
Mmab	-6646	-6987
Mmachc	-6958	-7440
Mmadhc	-6728	-7010
Mms19	-971	1272
Mmut	-7065	-7739
Mocos	-927	3247
Mocs1	-400	-4892
Mocs2	-5243	-1035
Mocs3	1359	-712
Morc2b	1565	2940
Mpc1	-7043	-7036
Mpc2	-7294	-7670
Mpst	-5914	-5311
Mri1	-4671	-3221
Msmo1	4477	3773
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
mt-Co1	-7257	-7632
mt-Co2	-7163	-6523
mt-Co3	-7307	-7023
mt-Cytb	-6947	-7620
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd5	-6386	-7564
mt-Nd6	-6677	-7251
Mtap	-672	-5228
Mtf1	-1900	-3101
Mthfd1	-5420	-5469
Mthfd1l	5552	6105
Mthfd2	6809	5263
Mthfd2l	-2670	-2109
Mthfr	3884	1934
Mthfsl	3679	4224
Mtm1	-4334	-5378
Mtmr1	3788	958
Mtmr10	-4510	-3036
Mtmr12	4967	6598
Mtmr14	-1063	-2895
Mtmr2	-1866	-4271
Mtmr3	717	-3312
Mtmr4	-4330	-6504
Mtmr6	6520	4975
Mtmr7	1286	2328
Mtmr9	3730	-942
Mtr	-6792	-7533
Mtrr	47	-4999
Mvd	-786	1263
Mvk	-841	881
N6amt1	-2262	-4037
Naalad2	7383	6674
Nadk	-1215	2371
Nadk2	-6714	-7698
Nadsyn1	-979	-607
Naglu	4598	2203
Nampt	-6518	-7541
Naprt	-5102	-6540
Nat8l	2705	-4548
Naxd	401	-3535
Naxe	-4750	-6089
Ncoa1	-4484	-6419
Ncoa2	-3912	-6801
Ncoa3	-6727	-4373
Ncoa6	-1555	-3479
Ncor1	-4730	-6152
Ncor2	4764	3742
Ndc1	-3676	-4825
Ndor1	-136	4876
Ndst1	-1729	-4940
Ndst2	4415	2740
Ndst3	3651	3254
Ndufa1	-5430	-6709
Ndufa10	-7288	-7572
Ndufa11	-7330	-7448
Ndufa12	-7240	-7308
Ndufa13	-7053	-7089
Ndufa2	-6895	-6030
Ndufa3	-7000	-7510
Ndufa4	-7274	-7232
Ndufa5	-7189	-7647
Ndufa6	-6698	-7117
Ndufa7	-7328	-7459
Ndufa8	-7315	-7154
Ndufa9	-7317	-7720
Ndufab1	-7247	-7579
Ndufaf1	-7011	-7559
Ndufaf2	-4758	-5261
Ndufaf3	-4910	-5440
Ndufaf4	-6419	-7254
Ndufaf5	-5750	-6463
Ndufaf6	-6271	-7083
Ndufaf7	-5738	-6678
Ndufb1-ps	-5319	-6906
Ndufb10	-7199	-7209
Ndufb2	-7214	-7114
Ndufb3	-6549	-6607
Ndufb4	-7132	-7245
Ndufb5	-7181	-6935
Ndufb6	-6950	-7112
Ndufb7	-7225	-6331
Ndufb8	-7343	-7800
Ndufb9	-7140	-7223
Ndufc1	-6951	-7311
Ndufc2	-7325	-7719
Ndufs1	-7157	-7633
Ndufs2	-7314	-7534
Ndufs3	-7291	-7530
Ndufs4	-7275	-7583
Ndufs5	-7010	-7087
Ndufs6	-7098	-7550
Ndufs7	-7258	-6981
Ndufs8	-7303	-7304
Ndufv1	-7186	-6904
Ndufv2	-7260	-7683
Ndufv3	-7034	-7419
Neu1	-4503	-122
Neu3	-2654	-2701
Nfs1	-7331	-7674
Nfya	-3456	1336
Nfyb	-2643	-1716
Nfyc	-6029	-6006
Nhlrc1	-4708	-4482
Nme1	-1429	4003
Nme2	-6361	-4594
Nme3	2828	560
Nme4	-5156	-6501
Nmnat1	-6055	-7266
Nmnat2	644	574
Nmnat3	-6111	-7185
Nmral1	-5383	-4338
Nmrk1	-738	-469
Nmrk2	6658	6406
Nnmt	5824	4237
Nnt	-6917	-7798
Nos3	-4231	-4860
Nosip	-1308	3016
Nostrin	-945	1936
Npas2	5604	-295
Nqo1	-3232	-6640
Nqo2	-6230	-7125
Nr1d1	1296	-175
Nr1h2	-243	1102
Nr1h3	-1853	-4977
Nr1h4	4445	220
Nrf1	2046	1078
Nsdhl	3643	3013
Nt5c	6217	6124
Nt5c1a	-5123	-6349
Nt5c2	5406	6040
Nt5c3	-5447	-6593
Nt5e	6721	6790
Nt5m	-2365	-3283
Nubp1	5521	5384
Nubp2	3130	-191
Nubpl	-6153	-6907
Nudt1	-3113	-3950
Nudt11	5122	-1143
Nudt12	-5274	-6487
Nudt13	-4189	-4487
Nudt15	-5961	-6686
Nudt16	5348	6128
Nudt18	6349	6174
Nudt19	-6768	-6057
Nudt3	-6816	-5921
Nudt4	6280	5857
Nudt5	3344	1497
Nudt7	-6026	-7008
Nudt9	-3876	-4608
Nup107	-1252	-1977
Nup133	-2488	-1920
Nup153	608	1264
Nup155	3051	361
Nup160	2576	936
Nup188	1219	1677
Nup205	-670	-3324
Nup210	-5985	-6834
Nup214	-1565	-479
Nup35	1447	-1156
Nup37	-326	-4277
Nup43	-462	-1511
Nup50	-566	-2471
Nup54	-939	-4619
Nup62	-5422	-4685
Nup85	-2481	-84
Nup88	-1840	-4528
Nup93	4359	4421
Nup98	3276	-3680
Nupl2	-3657	-3335
Oat	-6828	-7525
Oaz1	-6430	-4907
Oaz2	-6186	-4745
Ocrl	782	-3741
Odc1	5704	3746
Ogdh	-7013	-7475
Ogn	6618	4809
Omd	6306	6521
Oplah	-4843	-7513
Ormdl2	-76	2290
Ormdl3	6163	2491
Osbp	-4631	-5804
Osbpl10	3404	-2455
Osbpl1a	-6498	-7356
Osbpl2	-5898	-6247
Osbpl3	2824	4437
Osbpl5	6889	6037
Osbpl6	-6391	-7399
Osbpl7	2072	2600
Osbpl8	1904	-1789
Osbpl9	4590	3483
Oxct1	-6455	-7560
Paics	-5585	-5642
Pank1	-6745	-7785
Pank2	2335	2744
Pank3	-2321	-3208
Pank4	-6668	-6602
Paox	3632	-605
Papss1	6380	4162
Papss2	-4199	-3702
Parp10	196	3300
Parp14	-5002	3876
Parp16	4912	3006
Parp4	1908	2027
Parp6	-3161	-2401
Parp8	4406	4323
Parp9	3441	5371
Pcbd1	2289	1160
Pcca	-7022	-7738
Pccb	-7054	-7359
Pck1	1338	425
Pck2	4082	2129
Pctp	-3512	-6069
Pcx	-661	-6300
Pcyt1a	-3848	-5758
Pcyt1b	3225	-2052
Pcyt2	-6723	-7048
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Pdk1	4156	-6364
Pdk2	-6889	-7055
Pdk3	6805	6440
Pdk4	-1655	1645
Pdp1	-4181	-5275
Pdp2	-5917	-7570
Pdpr	-5996	-7506
Pdss1	-6299	-6919
Pdss2	-6819	-7474
Pdxk	-4818	-3469
Pdzd11	3364	2897
Pecr	-5886	-6147
Pemt	1711	3261
Pex11a	-6742	-7544
Pfas	-1120	647
Pfkfb1	-5631	-7672
Pfkfb3	5566	2556
Pfkfb4	1327	920
Pfkl	2644	-5278
Pfkm	-6806	-6837
Pfkp	6325	6660
Pgam1	-1039	-4657
Pgam2	-6840	-6595
Pgd	6119	3270
Pgk1	1605	-5844
Pgls	-4011	-4440
Pgm1	-6725	-7257
Pgm2	528	4018
Pgm2l1	-3658	-4003
Pgp	-5202	-4673
Pgs1	-2297	-164
Phgdh	4921	2827
Phka1	-2120	-6623
Phka2	-1089	-937
Phkb	-5410	-7064
Phkg1	-7030	-6803
Phkg2	772	2264
Phospho1	-4307	-351
Phyh	-7261	-7709
Phykpl	-2929	-717
Pi4k2a	5812	4741
Pi4k2b	6254	5089
Pi4ka	-4075	-5225
Pi4kb	-410	-2942
Pias4	-3508	-2197
Pik3c2a	-3001	-2146
Pik3c2b	-3537	-6207
Pik3c3	1891	-2240
Pik3ca	5242	5659
Pik3cb	3757	6013
Pik3cd	-120	1463
Pik3cg	4057	-374
Pik3r1	-7121	-7646
Pik3r2	7218	5112
Pik3r3	5367	1103
Pik3r4	480	-3782
Pik3r5	3057	3873
Pik3r6	-4434	-4988
Pikfyve	3766	3640
Pip4k2a	6260	5583
Pip4k2b	-575	-1112
Pip4k2c	207	-860
Pip5k1a	6376	5464
Pip5k1b	3999	-4337
Pip5k1c	3011	4725
Pipox	3254	2820
Pitpnb	298	2242
Pitpnm1	244	1871
Pitpnm2	-6287	-2813
Pitpnm3	-5784	-7187
Pkm	-5840	-6250
Pla1a	7199	6333
Pla2g12a	-3760	-6921
Pla2g15	32	-2369
Pla2g3	-2292	4799
Pla2g4a	7342	6860
Pla2g4e	-6588	-6369
Pla2g5	-6711	-7781
Pla2g6	-1374	-1982
Pla2r1	2134	2981
Plaat1	-6297	-6387
Plaat3	-5135	-6443
Plb1	-2327	-2998
Plbd1	-6752	-7782
Plcb1	-977	766
Plcb2	-4621	-1825
Plcb3	-3277	-2733
Plcb4	-980	6820
Plcd1	1240	-1148
Plcd3	-2934	1688
Plcd4	-800	1644
Plce1	-4298	769
Plcg1	-3635	-5144
Plcg2	7267	6597
Pld1	4581	4263
Pld2	-2706	-947
Pld3	6910	3086
Pld4	-1219	844
Plekha1	6078	6478
Plekha2	3712	-1730
Plekha3	3213	5560
Plekha4	7064	6689
Plekha5	-1282	-3486
Plekha6	6571	5910
Plekha8	611	1402
Plin1	-369	-3417
Plin2	-2436	-5931
Plin3	-6858	-7441
Plpp1	3994	6410
Plpp2	5311	4496
Plpp3	5504	6400
Plpp6	-4146	-6266
Pmvk	-4994	-4203
Pnpla2	-6697	-6659
Pnpla3	-2880	-773
Pnpla6	2839	3101
Pnpla7	-2916	-4735
Pnpla8	-6089	-6606
Pnpo	-4377	-5902
Podxl2	-1234	-151
Pold1	-2843	-1568
Pom121	-5732	-2088
Pon2	7070	6950
Pon3	1714	1862
Por	463	-2223
Ppa1	-3881	-5184
Ppa2	-6676	-6918
Ppara	-6545	-7563
Ppard	-5588	-4490
Pparg	-4842	-2722
Ppargc1a	-6363	-7511
Ppargc1b	-5894	-3355
Ppat	-3441	-3578
Ppcdc	-1394	-3889
Ppcs	-3647	-4057
Ppip5k1	5606	230
Ppip5k2	-5042	-7553
Ppm1k	-6684	-7715
Ppm1l	-6979	-7779
Ppox	-1067	-1544
Ppp1ca	-2389	-1250
Ppp1cb	-6139	-5952
Ppp1cc	-3515	-5893
Ppp1r3c	3377	3174
Ppp2ca	1302	1549
Ppp2cb	2162	-1862
Ppp2r1a	-5112	-3845
Ppp2r1b	-1090	-2605
Ppp2r5d	-3601	-2560
Ppt1	800	-4376
Ppt2	-5289	-5808
Prelp	6330	6402
Prkaa2	-6100	-7414
Prkab2	7420	5930
Prkaca	-6075	-5990
Prkacb	3875	-3919
Prkag2	4029	-2192
Prkar1a	6142	4210
Prkar1b	1256	1039
Prkar2a	-4064	-4969
Prkar2b	3433	313
Prkca	5539	5603
Prkd1	-5984	-6614
Prkd2	-6209	-2620
Prkd3	2420	-501
Prkg2	108	528
Prodh	-7310	-7241
Prps1l3	-1623	-3945
Prps2	-93	-5308
Prxl2b	2509	-3979
Psap	-7208	-7432
Psat1	7217	5483
Psma1	-5057	-5354
Psma3	-1668	-1270
Psma4	-4195	-5256
Psma5	917	4879
Psma6	-6198	-4392
Psma7	-5203	-1132
Psmb1	-3490	-1504
Psmb10	3247	6154
Psmb2	-6229	-6389
Psmb3	-6394	-4507
Psmb4	-4157	-2719
Psmb5	-5358	-2463
Psmb6	-5905	-4631
Psmb7	-6295	-6022
Psmb8	188	2895
Psmb9	239	987
Psmc1	-4509	-1482
Psmc2	-5438	-4371
Psmc3	-5727	-3198
Psmc4	580	1965
Psmc5	-5068	-3092
Psmc6	-3319	55
Psmd1	-4493	-2930
Psmd10	2830	-1174
Psmd11	5474	5901
Psmd12	-5949	-6045
Psmd13	2269	4514
Psmd14	1389	1667
Psmd2	-4258	-2549
Psmd3	-5414	-2387
Psmd4	-73	2814
Psmd5	2751	2805
Psmd6	-2219	-3583
Psmd7	-3344	2462
Psmd8	5830	6151
Psmd9	811	-3604
Psme1	-7082	-7176
Psme2b	-2823	-3837
Psme3	-4430	-5111
Psme4	-5860	-5252
Psmf1	1562	263
Psph	-790	-3930
Pstk	-5599	-2337
Ptdss1	4612	2691
Ptdss2	-4069	-5792
Pten	679	-2222
Ptgds	6881	-7629
Ptges	-2486	1029
Ptges2	-7009	-6869
Ptges3	-3953	-1978
Ptgis	7197	6190
Ptgr1	3065	664
Ptgr2	-7249	-7772
Ptgs1	2392	1813
Ptgs2	5209	6187
Ptpmt1	-4962	-3166
Ptpn13	6035	6508
Pts	-5872	-4675
Pxmp2	-6949	-7658
Pycr1	6421	4528
Pycr2	3676	3750
Pygb	-6106	-5967
Pygl	5543	1615
Pygm	-6719	-7002
Qdpr	-5622	-6805
Rab14	-5276	-6634
Rab4a	1717	2240
Rab5a	5098	86
Rae1	-2439	-1886
Ranbp2	1943	-1227
Rap1a	3944	-2069
Rapgef3	-5740	-4083
Rapgef4	3528	4499
Rbks	1727	1278
Rbp1	7370	6838
Rbp4	6701	6970
Rdh11	6388	6267
Retsat	-5701	-5739
Rfk	-5559	-4174
Rgl1	-2041	-3498
Rhd	6382	214
Rida	-1294	-3911
Rnls	-4878	-5257
Rora	4753	1898
Rpe	2080	1299
Rpia	-3546	-5241
Rpl10-ps3	3212	1228
Rpl10a	2365	826
Rpl11	-1842	-1611
Rpl12	4829	5011
Rpl13	-1673	-925
Rpl13a	3206	1423
Rpl14	-1056	-1817
Rpl18	-544	-2116
Rpl18a	-1661	-1683
Rpl19	1021	-223
Rpl22l1	-697	990
Rpl23	893	-998
Rpl26	-440	315
Rpl27	-3812	-3262
Rpl28	-3522	-3053
Rpl29	-3071	-3308
Rpl3	6113	6294
Rpl30	-2113	-2803
Rpl32	210	-2635
Rpl34	639	-1667
Rpl35	-731	-1020
Rpl36	-4693	-3549
Rpl37a	1027	-952
Rpl38	2973	-609
Rpl3l	-7308	-7793
Rpl4	2299	-567
Rpl5	767	2478
Rpl6	-669	-2330
Rpl7a	-2054	-3718
Rpl8	-4247	-3018
Rplp1	1737	1206
Rps11	315	-2551
Rps12	2728	884
Rps13	-5050	-5764
Rps14	-1071	-1798
Rps15	-1045	-2489
Rps15a	-3231	-2769
Rps16	900	-494
Rps17	-4875	-5562
Rps19	-44	-2802
Rps20	2098	1064
Rps21	1421	-1394
Rps24	69	-130
Rps25	-2930	-2703
Rps27a	-1504	-1029
Rps27l	282	1037
Rps28	3137	-561
Rps3a1	-1317	-1655
Rps4x	810	-303
Rps5	1452	1852
Rps7	-2886	-1733
Rps8	1432	-1256
Rps9	-212	-1205
Rpsa	-3636	-3074
Rrm1	3799	886
Rrm2	2262	4089
Rrm2b	-1706	-1735
Rtel1	3145	-29
Rufy1	-5737	-5890
Rxra	-6194	-6804
Rxrb	-3171	-3373
Sacm1l	-113	-2718
Samd8	4496	-3754
Samhd1	-4358	-5556
Sar1b	-6848	-7206
Sardh	2539	5655
Sat1	4779	5077
Sbf1	1902	1414
Sbf2	-2928	-5674
Sc5d	-2682	-5398
Scap	4774	3684
Scd4	-6898	-6839
Scly	-3134	-2787
Sco1	-6462	-6322
Sco2	-3709	-4161
Scp2	-6736	-7268
Sdc1	7061	4784
Sdc2	7435	6631
Sdc3	4012	3827
Sdc4	4355	-9
Sdha	-7346	-7813
Sdhb	-7295	-7485
Sdhc	-7227	-7405
Sdhd	-7333	-7791
Sdsl	3468	3601
Sec13	1575	39
Sec23a	4506	-802
Sec24a	-95	-2344
Sec24b	4189	3729
Sec24d	6468	5064
Secisbp2	-4438	-5781
Seh1l	326	-1812
Selenoi	-2946	-5031
Sephs2	-5227	-5985
Sepsecs	-179	-3327
Serinc1	4073	1017
Serinc2	6753	4559
Serinc3	-3501	-5421
Serinc5	-2159	-5552
Sgms1	-4032	-4342
Sgms2	6615	6828
Sgpl1	6521	3504
Sgpp1	5844	970
Sgsh	6079	5115
Shmt1	-5511	-6829
Shmt2	-6048	-5963
Shpk	3104	1025
Sin3a	625	-2529
Sin3b	467	164
Slc16a1	-5936	-4200
Slc16a3	7305	6044
Slc16a8	-4482	-3791
Slc19a1	-2616	-2444
Slc19a2	-1751	-2630
Slc22a1	-5870	-4886
Slc22a3	-6495	-7783
Slc22a5	-6362	-7316
Slc23a2	4778	5981
Slc25a1	6669	5317
Slc25a11	-7265	-7470
Slc25a12	-7001	-7181
Slc25a13	-5896	-6938
Slc25a14	4008	2705
Slc25a15	-1980	-6396
Slc25a16	-3736	-5864
Slc25a17	-336	-4956
Slc25a19	-6144	-5814
Slc25a20	-6911	-7554
Slc25a27	1019	1297
Slc25a28	-3690	-3434
Slc25a32	4470	3503
Slc25a37	-2322	-5900
Slc26a2	-759	-1286
Slc27a1	-6130	-6336
Slc27a3	4118	4704
Slc2a1	7348	6876
Slc35b2	4862	161
Slc35b3	5663	5610
Slc35d1	2883	2184
Slc35d2	6737	5737
Slc36a4	5528	-2185
Slc37a1	3329	934
Slc37a2	-4829	-6473
Slc37a4	-4152	-3362
Slc3a2	4768	3376
Slc44a1	5879	3779
Slc44a2	-4747	-2604
Slc44a5	-4245	434
Slc46a1	4846	292
Slc52a2	3432	3353
Slc52a3	1321	2196
Slc5a6	-5362	-6601
Slc6a8	7009	3623
Slc7a5	7017	6153
Slc9a1	4694	3003
Slco2b1	-3299	-5651
Smarcd3	-4349	-759
Smox	5632	4897
Smpd1	-6969	-6721
Smpd2	-5709	-5563
Smpd3	4558	4699
Smpd4	-3589	-5217
Sms	6724	2499
Sord	-7218	-7795
Sp1	2620	521
Sphk1	6933	6215
Sphk2	-1665	-844
Spr	-5793	-3582
Sptlc1	2960	-1311
Sptlc2	4018	3419
Sptssa	-909	-3305
Sqle	4439	3886
Srd5a1	1673	1129
Srd5a3	4993	3726
Srebf1	5979	2962
Srebf2	1180	1001
Srm	4398	4199
Srr	5378	4509
St3gal1	3058	716
St3gal2	6995	5852
St3gal3	-6777	-6624
St3gal4	4466	-4957
St3gal6	-4673	-4593
St6galnac6	-7184	-7584
Stab2	229	2485
Star	7459	7044
Stard10	4205	2960
Stard3	-4839	-3589
Stard3nl	2122	3211
Stard4	-1094	-3978
Stard5	-619	-2172
Stard6	4762	3926
Stard7	-6787	-7338
Stk11	-6289	-2130
Stx1a	2912	1003
Stxbp1	3699	-213
Sucla2	-7292	-7689
Suclg1	-7259	-7645
Suclg2	-7193	-7724
Sult5a1	7465	469
Sumf1	6244	3765
Sumo2	-1525	-5695
Suox	-4099	-5999
Surf1	-5087	-5645
Synj1	2943	-3070
Synj2	996	-2290
Taco1	-6970	-7208
Taldo1	6239	4907
Taz	-5545	-5487
Tbl1x	3008	-5102
Tbl1xr1	4225	-2715
Tbxas1	-921	2117
Tcn2	-3605	-5826
Tecr	-7151	-6741
Tecrl	-1100	5110
Tgs1	-4991	-5508
Them4	-5770	-5601
Thrap3	-2633	-3264
Thrsp	-5942	-5944
Thtpa	-3498	-3852
Tiam2	6979	6942
Timmdc1	-6360	-5463
Tk1	-553	3398
Tk2	3504	3175
Tkfc	3707	2727
Tkt	2738	-1742
Tm7sf2	-406	177
Tmem126b	-5883	-7021
Tmem86b	-4739	-1755
Tnfaip8	-6652	-7637
Tnfaip8l1	914	-2521
Tnfaip8l2	254	223
Tnfrsf21	-5776	-3833
Tpi1	-2612	-5131
Tpk1	1805	-211
Tpmt	-393	1145
Tpr	5510	4178
Tpst1	1542	203
Tpst2	-2866	-1310
Trap1	-6975	-6844
Trib3	-3278	1445
Trmt112	390	1149
Tspo	7491	6647
Tst	-6293	-7045
Ttpa	248	-5360
Ttr	-2307	6470
Txn1	1859	953
Txn2	-6882	-6420
Txnrd1	-793	-2917
Tymp	-3460	-596
Tyms	5145	3866
Ubb	5763	-1908
Ubc	-1436	-1699
Ube2i	3577	1079
Ubiad1	-5027	-3222
Uck1	-2232	453
Uck2	7299	6553
Uckl1	-4707	-2598
Ucp2	-3935	3288
Ucp3	-3606	-5388
Ugcg	906	-4712
Ugdh	6134	5765
Ugp2	-4394	-5740
Umps	-1832	-4076
Upp1	4475	4635
Upp2	1322	746
Uqcr10	-6171	-4525
Uqcr11	-7327	-7657
Uqcrb	-6857	-7389
Uqcrc1	-7297	-7415
Uqcrc2	-7191	-7618
Uqcrfs1	-7311	-7599
Uqcrh	-7334	-7571
Uqcrq	-7158	-7033
Urod	-6633	-6356
Uros	-3819	-6314
Ust	6358	6176
Vac14	3280	-355
Vamp2	-3875	-96
Vapa	441	-3564
Vapb	-3523	-3980
Vcan	7188	6694
Vdac1	-7008	-7195
Vdr	-724	-161
Vkorc1	6425	5377
Vkorc1l1	5981	-1057
Wasl	2624	5412
Xdh	-5698	-5467
Xylt1	6328	6030
Xylt2	2935	-1769
Zdhhc21	4006	5338

---

---

Mitochondrial-translation

Mitochondrial-translation

metric	value
setSize	94
pMANOVA	6.95e-44
p.adjustMANOVA	1.78e-41
s.dist	1.12
s.young	-0.825
s.old	-0.758
p.young	1.11e-43
p.old	4.24e-37

Top 20 genes

Gene	young	old
Mrpl30	-7337	-7761
Mrpl42	-7248	-7608
Ptcd3	-7230	-7612
Mrps35	-7210	-7615
Mrps17	-7178	-7576
Mrpl2	-7320	-7372
Mrps9	-6971	-7623
Mrpl45	-6896	-7603
Mrpl28	-6906	-7373
Tufm	-6846	-7363
Mrpl9	-6996	-7202
Mrpl46	-6817	-7379
Mrpl51	-7056	-7044
Mtif2	-6744	-7351
Gfm1	-6643	-7457
Mrps31	-6624	-7462
Mrpl3	-6890	-7156
Mrps27	-6764	-7263
Mrpl1	-6750	-7265
Gfm2	-6544	-7469

Click HERE to show all gene set members

All member genes

	young	old
Aurkaip1	-6248	-5678
Chchd1	-5921	-5916
Dap3	-6390	-6628
Eral1	-5904	-6599
Gadd45gip1	-6867	-6703
Gfm1	-6643	-7457
Gfm2	-6544	-7469
Mrpl1	-6750	-7265
Mrpl10	-5595	-5933
Mrpl11	-5991	-5910
Mrpl12	-7029	-6604
Mrpl13	-5916	-6619
Mrpl14	-6990	-6964
Mrpl15	-6574	-6827
Mrpl16	-5878	-6598
Mrpl17	-5372	-4564
Mrpl18	-6929	-7035
Mrpl19	-6834	-6958
Mrpl2	-7320	-7372
Mrpl20	-5318	-4089
Mrpl21	-5591	-6947
Mrpl22	-5839	-6141
Mrpl23	-6924	-4943
Mrpl24	-5493	-4092
Mrpl27	-4868	-4867
Mrpl28	-6906	-7373
Mrpl3	-6890	-7156
Mrpl30	-7337	-7761
Mrpl32	-5449	-6000
Mrpl33	-676	3231
Mrpl34	-6559	-6570
Mrpl35	-6678	-7167
Mrpl36	-4714	-4959
Mrpl37	-6747	-7068
Mrpl38	-6844	-6174
Mrpl39	-6696	-7130
Mrpl4	-6884	-6566
Mrpl40	-3530	-4283
Mrpl41	-6758	-6786
Mrpl42	-7248	-7608
Mrpl43	-5164	-5466
Mrpl44	-6513	-6841
Mrpl45	-6896	-7603
Mrpl46	-6817	-7379
Mrpl47	-6690	-6931
Mrpl48	-4965	-2296
Mrpl49	-5909	-5838
Mrpl50	-6278	-7053
Mrpl51	-7056	-7044
Mrpl52	-994	253
Mrpl53	-6252	-4354
Mrpl54	-1065	-2562
Mrpl55	-7064	-6715
Mrpl57	-2056	-4071
Mrpl58	-6710	-6615
Mrpl9	-6996	-7202
Mrps10	-1566	1880
Mrps11	-5399	-5798
Mrps12	-4262	-4111
Mrps14	-6073	-6439
Mrps15	-6805	-6956
Mrps16	-6308	-6130
Mrps17	-7178	-7576
Mrps18a	-6175	-6605
Mrps18b	-5938	-4872
Mrps18c	-5687	-6088
Mrps2	-6425	-7205
Mrps21	-6827	-7070
Mrps22	-5305	-6723
Mrps23	-6635	-5774
Mrps24	-6748	-6081
Mrps25	-6490	-6633
Mrps26	-5415	-3403
Mrps27	-6764	-7263
Mrps28	-6850	-6886
Mrps30	-6407	-6943
Mrps31	-6624	-7462
Mrps33	-6284	-6495
Mrps34	-6156	-4884
Mrps35	-7210	-7615
Mrps36	-6283	-6967
Mrps5	-6689	-6857
Mrps6	-4817	-1971
Mrps7	-6460	-6613
Mrps9	-6971	-7623
Mrrf	-6453	-6787
Mtfmt	-3436	-3006
Mtif2	-6744	-7351
Mtif3	-5780	-5500
Mtrf1l	-5597	-5796
Oxa1l	-7035	-6627
Ptcd3	-7230	-7612
Tsfm	-6347	-6440
Tufm	-6846	-7363

---

---

Mitochondrial-translation-elongation

Mitochondrial-translation-elongation

metric	value
setSize	88
pMANOVA	2.9e-41
p.adjustMANOVA	6.18e-39
s.dist	1.12
s.young	-0.827
s.old	-0.758
p.young	3.38e-41
p.old	8.11e-35

Top 20 genes

Gene	young	old
Mrpl30	-7337	-7761
Mrpl42	-7248	-7608
Ptcd3	-7230	-7612
Mrps35	-7210	-7615
Mrps17	-7178	-7576
Mrpl2	-7320	-7372
Mrps9	-6971	-7623
Mrpl45	-6896	-7603
Mrpl28	-6906	-7373
Tufm	-6846	-7363
Mrpl9	-6996	-7202
Mrpl46	-6817	-7379
Mrpl51	-7056	-7044
Gfm1	-6643	-7457
Mrps31	-6624	-7462
Mrpl3	-6890	-7156
Mrps27	-6764	-7263
Mrpl1	-6750	-7265
Mrpl18	-6929	-7035
Mrpl14	-6990	-6964

Click HERE to show all gene set members

All member genes

	young	old
Aurkaip1	-6248	-5678
Chchd1	-5921	-5916
Dap3	-6390	-6628
Eral1	-5904	-6599
Gadd45gip1	-6867	-6703
Gfm1	-6643	-7457
Mrpl1	-6750	-7265
Mrpl10	-5595	-5933
Mrpl11	-5991	-5910
Mrpl12	-7029	-6604
Mrpl13	-5916	-6619
Mrpl14	-6990	-6964
Mrpl15	-6574	-6827
Mrpl16	-5878	-6598
Mrpl17	-5372	-4564
Mrpl18	-6929	-7035
Mrpl19	-6834	-6958
Mrpl2	-7320	-7372
Mrpl20	-5318	-4089
Mrpl21	-5591	-6947
Mrpl22	-5839	-6141
Mrpl23	-6924	-4943
Mrpl24	-5493	-4092
Mrpl27	-4868	-4867
Mrpl28	-6906	-7373
Mrpl3	-6890	-7156
Mrpl30	-7337	-7761
Mrpl32	-5449	-6000
Mrpl33	-676	3231
Mrpl34	-6559	-6570
Mrpl35	-6678	-7167
Mrpl36	-4714	-4959
Mrpl37	-6747	-7068
Mrpl38	-6844	-6174
Mrpl39	-6696	-7130
Mrpl4	-6884	-6566
Mrpl40	-3530	-4283
Mrpl41	-6758	-6786
Mrpl42	-7248	-7608
Mrpl43	-5164	-5466
Mrpl44	-6513	-6841
Mrpl45	-6896	-7603
Mrpl46	-6817	-7379
Mrpl47	-6690	-6931
Mrpl48	-4965	-2296
Mrpl49	-5909	-5838
Mrpl50	-6278	-7053
Mrpl51	-7056	-7044
Mrpl52	-994	253
Mrpl53	-6252	-4354
Mrpl54	-1065	-2562
Mrpl55	-7064	-6715
Mrpl57	-2056	-4071
Mrpl58	-6710	-6615
Mrpl9	-6996	-7202
Mrps10	-1566	1880
Mrps11	-5399	-5798
Mrps12	-4262	-4111
Mrps14	-6073	-6439
Mrps15	-6805	-6956
Mrps16	-6308	-6130
Mrps17	-7178	-7576
Mrps18a	-6175	-6605
Mrps18b	-5938	-4872
Mrps18c	-5687	-6088
Mrps2	-6425	-7205
Mrps21	-6827	-7070
Mrps22	-5305	-6723
Mrps23	-6635	-5774
Mrps24	-6748	-6081
Mrps25	-6490	-6633
Mrps26	-5415	-3403
Mrps27	-6764	-7263
Mrps28	-6850	-6886
Mrps30	-6407	-6943
Mrps31	-6624	-7462
Mrps33	-6284	-6495
Mrps34	-6156	-4884
Mrps35	-7210	-7615
Mrps36	-6283	-6967
Mrps5	-6689	-6857
Mrps6	-4817	-1971
Mrps7	-6460	-6613
Mrps9	-6971	-7623
Oxa1l	-7035	-6627
Ptcd3	-7230	-7612
Tsfm	-6347	-6440
Tufm	-6846	-7363

---

---

Mitochondrial-translation-termination

Mitochondrial-translation-termination

metric	value
setSize	88
pMANOVA	4.51e-41
p.adjustMANOVA	8.23e-39
s.dist	1.12
s.young	-0.825
s.old	-0.756
p.young	5.15e-41
p.old	1.18e-34

Top 20 genes

Gene	young	old
Mrpl30	-7337	-7761
Mrpl42	-7248	-7608
Ptcd3	-7230	-7612
Mrps35	-7210	-7615
Mrps17	-7178	-7576
Mrpl2	-7320	-7372
Mrps9	-6971	-7623
Mrpl45	-6896	-7603
Mrpl28	-6906	-7373
Mrpl9	-6996	-7202
Mrpl46	-6817	-7379
Mrpl51	-7056	-7044
Mrps31	-6624	-7462
Mrpl3	-6890	-7156
Mrps27	-6764	-7263
Mrpl1	-6750	-7265
Gfm2	-6544	-7469
Mrpl18	-6929	-7035
Mrpl14	-6990	-6964
Mrps21	-6827	-7070

Click HERE to show all gene set members

All member genes

	young	old
Aurkaip1	-6248	-5678
Chchd1	-5921	-5916
Dap3	-6390	-6628
Eral1	-5904	-6599
Gadd45gip1	-6867	-6703
Gfm2	-6544	-7469
Mrpl1	-6750	-7265
Mrpl10	-5595	-5933
Mrpl11	-5991	-5910
Mrpl12	-7029	-6604
Mrpl13	-5916	-6619
Mrpl14	-6990	-6964
Mrpl15	-6574	-6827
Mrpl16	-5878	-6598
Mrpl17	-5372	-4564
Mrpl18	-6929	-7035
Mrpl19	-6834	-6958
Mrpl2	-7320	-7372
Mrpl20	-5318	-4089
Mrpl21	-5591	-6947
Mrpl22	-5839	-6141
Mrpl23	-6924	-4943
Mrpl24	-5493	-4092
Mrpl27	-4868	-4867
Mrpl28	-6906	-7373
Mrpl3	-6890	-7156
Mrpl30	-7337	-7761
Mrpl32	-5449	-6000
Mrpl33	-676	3231
Mrpl34	-6559	-6570
Mrpl35	-6678	-7167
Mrpl36	-4714	-4959
Mrpl37	-6747	-7068
Mrpl38	-6844	-6174
Mrpl39	-6696	-7130
Mrpl4	-6884	-6566
Mrpl40	-3530	-4283
Mrpl41	-6758	-6786
Mrpl42	-7248	-7608
Mrpl43	-5164	-5466
Mrpl44	-6513	-6841
Mrpl45	-6896	-7603
Mrpl46	-6817	-7379
Mrpl47	-6690	-6931
Mrpl48	-4965	-2296
Mrpl49	-5909	-5838
Mrpl50	-6278	-7053
Mrpl51	-7056	-7044
Mrpl52	-994	253
Mrpl53	-6252	-4354
Mrpl54	-1065	-2562
Mrpl55	-7064	-6715
Mrpl57	-2056	-4071
Mrpl58	-6710	-6615
Mrpl9	-6996	-7202
Mrps10	-1566	1880
Mrps11	-5399	-5798
Mrps12	-4262	-4111
Mrps14	-6073	-6439
Mrps15	-6805	-6956
Mrps16	-6308	-6130
Mrps17	-7178	-7576
Mrps18a	-6175	-6605
Mrps18b	-5938	-4872
Mrps18c	-5687	-6088
Mrps2	-6425	-7205
Mrps21	-6827	-7070
Mrps22	-5305	-6723
Mrps23	-6635	-5774
Mrps24	-6748	-6081
Mrps25	-6490	-6633
Mrps26	-5415	-3403
Mrps27	-6764	-7263
Mrps28	-6850	-6886
Mrps30	-6407	-6943
Mrps31	-6624	-7462
Mrps33	-6284	-6495
Mrps34	-6156	-4884
Mrps35	-7210	-7615
Mrps36	-6283	-6967
Mrps5	-6689	-6857
Mrps6	-4817	-1971
Mrps7	-6460	-6613
Mrps9	-6971	-7623
Mrrf	-6453	-6787
Mtrf1l	-5597	-5796
Oxa1l	-7035	-6627
Ptcd3	-7230	-7612

---

---

Mitochondrial-translation-initiation

Mitochondrial-translation-initiation

metric	value
setSize	88
pMANOVA	1.35e-40
p.adjustMANOVA	2.16e-38
s.dist	1.11
s.young	-0.821
s.old	-0.75
p.young	1.25e-40
p.old	4.3e-34

Top 20 genes

Gene	young	old
Mrpl30	-7337	-7761
Mrpl42	-7248	-7608
Ptcd3	-7230	-7612
Mrps35	-7210	-7615
Mrps17	-7178	-7576
Mrpl2	-7320	-7372
Mrps9	-6971	-7623
Mrpl45	-6896	-7603
Mrpl28	-6906	-7373
Mrpl9	-6996	-7202
Mrpl46	-6817	-7379
Mrpl51	-7056	-7044
Mtif2	-6744	-7351
Mrps31	-6624	-7462
Mrpl3	-6890	-7156
Mrps27	-6764	-7263
Mrpl1	-6750	-7265
Mrpl18	-6929	-7035
Mrpl14	-6990	-6964
Mrps21	-6827	-7070

Click HERE to show all gene set members

All member genes

	young	old
Aurkaip1	-6248	-5678
Chchd1	-5921	-5916
Dap3	-6390	-6628
Eral1	-5904	-6599
Gadd45gip1	-6867	-6703
Mrpl1	-6750	-7265
Mrpl10	-5595	-5933
Mrpl11	-5991	-5910
Mrpl12	-7029	-6604
Mrpl13	-5916	-6619
Mrpl14	-6990	-6964
Mrpl15	-6574	-6827
Mrpl16	-5878	-6598
Mrpl17	-5372	-4564
Mrpl18	-6929	-7035
Mrpl19	-6834	-6958
Mrpl2	-7320	-7372
Mrpl20	-5318	-4089
Mrpl21	-5591	-6947
Mrpl22	-5839	-6141
Mrpl23	-6924	-4943
Mrpl24	-5493	-4092
Mrpl27	-4868	-4867
Mrpl28	-6906	-7373
Mrpl3	-6890	-7156
Mrpl30	-7337	-7761
Mrpl32	-5449	-6000
Mrpl33	-676	3231
Mrpl34	-6559	-6570
Mrpl35	-6678	-7167
Mrpl36	-4714	-4959
Mrpl37	-6747	-7068
Mrpl38	-6844	-6174
Mrpl39	-6696	-7130
Mrpl4	-6884	-6566
Mrpl40	-3530	-4283
Mrpl41	-6758	-6786
Mrpl42	-7248	-7608
Mrpl43	-5164	-5466
Mrpl44	-6513	-6841
Mrpl45	-6896	-7603
Mrpl46	-6817	-7379
Mrpl47	-6690	-6931
Mrpl48	-4965	-2296
Mrpl49	-5909	-5838
Mrpl50	-6278	-7053
Mrpl51	-7056	-7044
Mrpl52	-994	253
Mrpl53	-6252	-4354
Mrpl54	-1065	-2562
Mrpl55	-7064	-6715
Mrpl57	-2056	-4071
Mrpl58	-6710	-6615
Mrpl9	-6996	-7202
Mrps10	-1566	1880
Mrps11	-5399	-5798
Mrps12	-4262	-4111
Mrps14	-6073	-6439
Mrps15	-6805	-6956
Mrps16	-6308	-6130
Mrps17	-7178	-7576
Mrps18a	-6175	-6605
Mrps18b	-5938	-4872
Mrps18c	-5687	-6088
Mrps2	-6425	-7205
Mrps21	-6827	-7070
Mrps22	-5305	-6723
Mrps23	-6635	-5774
Mrps24	-6748	-6081
Mrps25	-6490	-6633
Mrps26	-5415	-3403
Mrps27	-6764	-7263
Mrps28	-6850	-6886
Mrps30	-6407	-6943
Mrps31	-6624	-7462
Mrps33	-6284	-6495
Mrps34	-6156	-4884
Mrps35	-7210	-7615
Mrps36	-6283	-6967
Mrps5	-6689	-6857
Mrps6	-4817	-1971
Mrps7	-6460	-6613
Mrps9	-6971	-7623
Mtfmt	-3436	-3006
Mtif2	-6744	-7351
Mtif3	-5780	-5500
Oxa1l	-7035	-6627
Ptcd3	-7230	-7612

---

---

Extracellular-matrix-organization

Extracellular-matrix-organization

metric	value
setSize	228
pMANOVA	1.35e-38
p.adjustMANOVA	1.92e-36
s.dist	0.677
s.young	0.499
s.old	0.458
p.young	1.41e-38
p.old	1.08e-32

Top 20 genes

Gene	young	old
Ncam1	7473	7015
Col8a2	7452	6978
Tgfb2	7427	6986
P3h2	7374	7030
Col8a1	7519	6875
Col5a2	7480	6907
Mmp2	7497	6885
Mfap5	7485	6861
Lamc2	7360	6977
Cd44	7295	7013
Bgn	7481	6830
Tgfb3	7433	6863
Col12a1	7235	7031
Col16a1	7349	6856
Aspn	7430	6781
Loxl2	7336	6852
Loxl3	7361	6821
Ctsk	7416	6759
Col1a2	7362	6786
Ltbp3	7432	6685

Click HERE to show all gene set members

All member genes

	young	old
A2m	6437	1719
Actn1	7067	6336
Adam10	5268	3108
Adam12	5421	4313
Adam15	-324	-382
Adam17	289	-1999
Adam8	2453	-448
Adam9	7103	4428
Adamts1	4892	1782
Adamts14	3117	5979
Adamts2	7469	6535
Adamts3	-4916	-4222
Adamts4	4717	-509
Adamts5	3233	-4965
Adamts8	6496	5738
Adamts9	-4316	-4299
Agrn	-247	199
Aspn	7430	6781
Bgn	7481	6830
Bmp1	7236	6255
Bmp2	-2270	2145
Bmp4	6772	6517
Bmp7	-4799	-5293
Bsg	-6548	-7267
Capn1	5990	-1442
Capn10	2312	2828
Capn12	-4526	-585
Capn15	-4124	-1273
Capn2	6302	6179
Capn3	-753	-6755
Capn5	4499	6035
Capn6	6326	5177
Capn7	-2762	-5831
Capns1	5582	1432
Cask	4944	6083
Casp3	6837	4230
Cast	7085	6448
Cd151	-3387	-2499
Cd44	7295	7013
Cd47	4738	3661
Cma1	988	82
Col11a1	7093	6902
Col11a2	-1021	3528
Col12a1	7235	7031
Col13a1	2636	3872
Col14a1	7303	6796
Col15a1	6814	6634
Col16a1	7349	6856
Col18a1	6116	5391
Col1a1	7237	6629
Col1a2	7362	6786
Col20a1	2825	6268
Col23a1	5725	2177
Col25a1	-1076	474
Col26a1	7193	5097
Col27a1	7356	6638
Col28a1	215	3053
Col3a1	6563	6455
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col4a5	7202	6747
Col4a6	2683	4540
Col5a1	7233	6290
Col5a2	7480	6907
Col5a3	2225	-2736
Col6a1	7176	6438
Col6a2	6971	6524
Col6a3	5781	6084
Col6a6	1479	-6594
Col8a1	7519	6875
Col8a2	7452	6978
Col9a2	7498	6397
Colgalt1	4060	2838
Colgalt2	-4035	-2084
Comp	4501	6797
Crtap	6718	3923
Ctsb	-39	-2241
Ctsk	7416	6759
Ctss	3818	-193
Dag1	3395	1176
Dcn	7414	6701
Ddr1	7436	6320
Ddr2	5244	4992
Dmd	6489	6319
Dst	5571	5573
Efemp1	-4901	-7119
Efemp2	6926	5475
Eln	5907	4689
F11r	-352	-4343
Fbln1	-3620	3794
Fbln2	7256	6211
Fbln5	6795	6253
Fbn1	6968	6107
Fbn2	6918	5566
Fga	-3043	855
Fgb	-3889	1327
Fgf2	3347	-4613
Fmod	6247	6867
Fn1	7320	6491
Furin	1738	-2954
Hapln1	-1235	1714
Hspg2	6535	3769
Htra1	-756	-5946
Icam1	5132	3799
Icam2	-2435	-4834
Itga1	-2422	-3850
Itga11	6898	6561
Itga2	3765	6228
Itga2b	5803	437
Itga3	5715	5066
Itga4	610	3065
Itga5	7309	6750
Itga6	-5055	-3078
Itga7	6140	5835
Itga8	3673	5405
Itga9	6082	6594
Itgae	4962	3911
Itgal	2820	-2156
Itgav	7314	6700
Itgax	1846	526
Itgb1	6770	5825
Itgb3	7496	5721
Itgb4	2528	3814
Itgb5	7035	6117
Itgb6	-4680	-6503
Itgb7	2293	3037
Itgb8	6492	6501
Jam2	-3753	-6183
Jam3	4176	3665
Kdr	-5777	-7016
Lama2	7478	6628
Lama3	1858	-436
Lama4	3147	2662
Lama5	5048	-4782
Lamb1	6771	-983
Lamb2	2375	4485
Lamb3	-6638	-7066
Lamc1	7347	5936
Lamc2	7360	6977
Lamc3	6611	5684
Lox	7364	6358
Loxl1	7313	5950
Loxl2	7336	6852
Loxl3	7361	6821
Loxl4	6831	6223
Lrp4	2160	909
Ltbp1	2153	4810
Ltbp2	7174	6826
Ltbp3	7432	6685
Ltbp4	7265	5969
Lum	7163	6376
Matn4	4806	5530
Mfap1b	2060	3988
Mfap2	7084	3420
Mfap3	919	-6
Mfap4	7221	6243
Mfap5	7485	6861
Mmp11	4144	625
Mmp12	-333	2038
Mmp13	-101	-5501
Mmp14	7280	5623
Mmp15	-6801	-6688
Mmp16	3955	3586
Mmp17	1629	413
Mmp19	6383	3258
Mmp2	7497	6885
Mmp25	-298	32
Mmp3	-1265	4045
Mmp9	1226	-6359
Ncam1	7473	7015
Ncstn	2223	347
Nid1	6799	4441
Nid2	5838	3132
Nrxn1	1564	732
Ntn4	-2779	-5668
P3h1	6856	4702
P3h2	7374	7030
P3h3	7230	6562
P4ha1	4494	6389
P4ha2	-5915	-3841
P4ha3	6223	4289
P4hb	6441	4378
Pcolce	7373	6528
Pcolce2	3514	6586
Pdgfa	-2171	-2809
Pdgfb	-3222	-3725
Pecam1	-3282	-6290
Phykpl	-2929	-717
Plec	1669	2349
Plod1	-2323	2388
Plod2	7080	6224
Plod3	5833	4938
Ppib	5989	3349
Prkca	5539	5603
Psen1	-309	-25
Psg16	-4834	6002
Ptprs	6547	183
Pxdn	-3621	-6204
Scube1	6820	5249
Scube3	2333	4389
Sdc1	7061	4784
Sdc2	7435	6631
Sdc3	4012	3827
Sdc4	4355	-9
Serpine1	7216	6353
Serpinh1	1466	3868
Sh3pxd2a	5995	-2556
Sparc	6776	6134
Spock3	6480	6467
Spp1	4125	6580
Tgfb1	6984	5531
Tgfb2	7427	6986
Tgfb3	7433	6863
Thbs1	6742	6178
Timp1	7129	6798
Timp2	7029	5931
Tll1	5403	4589
Tll2	-784	-5372
Tnc	4757	6330
Tnr	4918	5633
Tnxb	6557	4769
Trappc4	-2363	396
Ttr	-2307	6470
Vcam1	4827	2422
Vcan	7188	6694
Vtn	-7117	-7433

---

---

Complex-I-biogenesis

Complex-I-biogenesis

metric	value
setSize	54
pMANOVA	1.62e-33
p.adjustMANOVA	2.07e-31
s.dist	1.3
s.young	-0.93
s.old	-0.904
p.young	2.28e-32
p.old	1.25e-30

Top 20 genes

Gene	young	old
Ndufb8	-7343	-7800
Ndufc2	-7325	-7719
Ndufa9	-7317	-7720
Ndufv2	-7260	-7683
Ndufa10	-7288	-7572
Ndufs4	-7275	-7583
Ndufs2	-7314	-7534
Ndufa5	-7189	-7647
Ndufab1	-7247	-7579
Ndufs3	-7291	-7530
Ndufa7	-7328	-7459
Ndufs1	-7157	-7633
Ndufa11	-7330	-7448
mt-Nd2	-7271	-7495
Ndufs6	-7098	-7550
Ndufs8	-7303	-7304
mt-Nd1	-7119	-7489
Ndufaf1	-7011	-7559
Ndufa12	-7240	-7308
Ndufa3	-7000	-7510

Click HERE to show all gene set members

All member genes

	young	old
Acad9	-6612	-6647
Ecsit	-6908	-6444
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd5	-6386	-7564
mt-Nd6	-6677	-7251
Ndufa1	-5430	-6709
Ndufa10	-7288	-7572
Ndufa11	-7330	-7448
Ndufa12	-7240	-7308
Ndufa13	-7053	-7089
Ndufa2	-6895	-6030
Ndufa3	-7000	-7510
Ndufa5	-7189	-7647
Ndufa6	-6698	-7117
Ndufa7	-7328	-7459
Ndufa8	-7315	-7154
Ndufa9	-7317	-7720
Ndufab1	-7247	-7579
Ndufaf1	-7011	-7559
Ndufaf2	-4758	-5261
Ndufaf3	-4910	-5440
Ndufaf4	-6419	-7254
Ndufaf5	-5750	-6463
Ndufaf6	-6271	-7083
Ndufaf7	-5738	-6678
Ndufb1-ps	-5319	-6906
Ndufb10	-7199	-7209
Ndufb2	-7214	-7114
Ndufb3	-6549	-6607
Ndufb4	-7132	-7245
Ndufb5	-7181	-6935
Ndufb6	-6950	-7112
Ndufb7	-7225	-6331
Ndufb8	-7343	-7800
Ndufb9	-7140	-7223
Ndufc1	-6951	-7311
Ndufc2	-7325	-7719
Ndufs1	-7157	-7633
Ndufs2	-7314	-7534
Ndufs3	-7291	-7530
Ndufs4	-7275	-7583
Ndufs5	-7010	-7087
Ndufs6	-7098	-7550
Ndufs7	-7258	-6981
Ndufs8	-7303	-7304
Ndufv1	-7186	-6904
Ndufv2	-7260	-7683
Ndufv3	-7034	-7419
Nubpl	-6153	-6907
Timmdc1	-6360	-5463
Tmem126b	-5883	-7021

---

---

Translation

Translation

metric	value
setSize	241
pMANOVA	4e-31
p.adjustMANOVA	4.66e-29
s.dist	0.595
s.young	-0.415
s.old	-0.426
p.young	1.35e-28
p.old	4.55e-30

Top 20 genes

Gene	young	old
Rpl3l	-7308	-7793
Mrpl30	-7337	-7761
Mrpl42	-7248	-7608
Ptcd3	-7230	-7612
Mrps35	-7210	-7615
Mrps17	-7178	-7576
Mrpl2	-7320	-7372
Mrps9	-6971	-7623
Mrpl45	-6896	-7603
Mrpl28	-6906	-7373
Fars2	-6885	-7333
Tufm	-6846	-7363
Mrpl9	-6996	-7202
Mrpl46	-6817	-7379
Mrpl51	-7056	-7044
Mtif2	-6744	-7351
Gfm1	-6643	-7457
Mrps31	-6624	-7462
Mrpl3	-6890	-7156
Mrps27	-6764	-7263

Click HERE to show all gene set members

All member genes

	young	old
Aars2	-6224	-6392
Aimp1	-2872	-3408
Aimp2	-1669	2875
Apeh	-5071	-1990
Aurkaip1	-6248	-5678
Cars2	-6673	-6550
Chchd1	-5921	-5916
Dap3	-6390	-6628
Dars2	-5581	-7062
Ddost	5379	-181
Ears2	-1578	-3330
Eef1a2	-6357	-5633
Eef1b2	637	-2698
Eef1d	-5848	-4473
Eef1e1	-4012	130
Eef1g	-3903	-4521
Eef2	4391	275
Eif1a	5914	5726
Eif2b1	-2994	-2186
Eif2b2	-1328	-2163
Eif2b3	3073	3436
Eif2b4	-6044	-4703
Eif2b5	-2667	-3106
Eif2s1	-806	-2500
Eif2s2	-2303	-4953
Eif2s3x	-4218	-6299
Eif3a	5490	-66
Eif3b	3099	2631
Eif3c	1453	-4912
Eif3d	3348	2210
Eif3e	3390	-106
Eif3f	-4014	-4796
Eif3g	-2184	-890
Eif3h	5226	367
Eif3i	-297	-2201
Eif3j2	4071	-745
Eif3k	-2704	-1973
Eif3l	-978	-1218
Eif3m	-5876	-5839
Eif4a1	4689	4812
Eif4a2	-1851	-4012
Eif4e	-5795	-5062
Eif4ebp1	-2737	-1088
Eif4g1	-5508	-5906
Eif4h	-1666	-2254
Eif5	3307	4034
Eif5b	-1589	-4589
Eral1	-5904	-6599
Etf1	2542	-2446
Fars2	-6885	-7333
Farsa	-4086	-2900
Farsb	-5407	-5600
Fau	519	-1304
Gadd45gip1	-6867	-6703
Gfm1	-6643	-7457
Gfm2	-6544	-7469
Gm11808	-5706	-216
Gspt1	-2246	-3914
Gspt2	5388	4818
Hars2	-5875	-6761
Iars2	-5691	-7099
Kars	-1031	-313
Lars2	-6814	-414
Mars2	-5106	-7011
Mrpl1	-6750	-7265
Mrpl10	-5595	-5933
Mrpl11	-5991	-5910
Mrpl12	-7029	-6604
Mrpl13	-5916	-6619
Mrpl14	-6990	-6964
Mrpl15	-6574	-6827
Mrpl16	-5878	-6598
Mrpl17	-5372	-4564
Mrpl18	-6929	-7035
Mrpl19	-6834	-6958
Mrpl2	-7320	-7372
Mrpl20	-5318	-4089
Mrpl21	-5591	-6947
Mrpl22	-5839	-6141
Mrpl23	-6924	-4943
Mrpl24	-5493	-4092
Mrpl27	-4868	-4867
Mrpl28	-6906	-7373
Mrpl3	-6890	-7156
Mrpl30	-7337	-7761
Mrpl32	-5449	-6000
Mrpl33	-676	3231
Mrpl34	-6559	-6570
Mrpl35	-6678	-7167
Mrpl36	-4714	-4959
Mrpl37	-6747	-7068
Mrpl38	-6844	-6174
Mrpl39	-6696	-7130
Mrpl4	-6884	-6566
Mrpl40	-3530	-4283
Mrpl41	-6758	-6786
Mrpl42	-7248	-7608
Mrpl43	-5164	-5466
Mrpl44	-6513	-6841
Mrpl45	-6896	-7603
Mrpl46	-6817	-7379
Mrpl47	-6690	-6931
Mrpl48	-4965	-2296
Mrpl49	-5909	-5838
Mrpl50	-6278	-7053
Mrpl51	-7056	-7044
Mrpl52	-994	253
Mrpl53	-6252	-4354
Mrpl54	-1065	-2562
Mrpl55	-7064	-6715
Mrpl57	-2056	-4071
Mrpl58	-6710	-6615
Mrpl9	-6996	-7202
Mrps10	-1566	1880
Mrps11	-5399	-5798
Mrps12	-4262	-4111
Mrps14	-6073	-6439
Mrps15	-6805	-6956
Mrps16	-6308	-6130
Mrps17	-7178	-7576
Mrps18a	-6175	-6605
Mrps18b	-5938	-4872
Mrps18c	-5687	-6088
Mrps2	-6425	-7205
Mrps21	-6827	-7070
Mrps22	-5305	-6723
Mrps23	-6635	-5774
Mrps24	-6748	-6081
Mrps25	-6490	-6633
Mrps26	-5415	-3403
Mrps27	-6764	-7263
Mrps28	-6850	-6886
Mrps30	-6407	-6943
Mrps31	-6624	-7462
Mrps33	-6284	-6495
Mrps34	-6156	-4884
Mrps35	-7210	-7615
Mrps36	-6283	-6967
Mrps5	-6689	-6857
Mrps6	-4817	-1971
Mrps7	-6460	-6613
Mrps9	-6971	-7623
Mrrf	-6453	-6787
Mtfmt	-3436	-3006
Mtif2	-6744	-7351
Mtif3	-5780	-5500
Mtrf1l	-5597	-5796
N6amt1	-2262	-4037
Nars2	-6694	-7073
Oxa1l	-7035	-6627
Pars2	-3576	-3342
Ppa1	-3881	-5184
Ppa2	-6676	-6918
Ptcd3	-7230	-7612
Rars2	-5676	-5759
Rpl10-ps3	3212	1228
Rpl10a	2365	826
Rpl11	-1842	-1611
Rpl12	4829	5011
Rpl13	-1673	-925
Rpl13a	3206	1423
Rpl14	-1056	-1817
Rpl18	-544	-2116
Rpl18a	-1661	-1683
Rpl19	1021	-223
Rpl22l1	-697	990
Rpl23	893	-998
Rpl26	-440	315
Rpl27	-3812	-3262
Rpl28	-3522	-3053
Rpl29	-3071	-3308
Rpl3	6113	6294
Rpl30	-2113	-2803
Rpl32	210	-2635
Rpl34	639	-1667
Rpl35	-731	-1020
Rpl36	-4693	-3549
Rpl37a	1027	-952
Rpl38	2973	-609
Rpl3l	-7308	-7793
Rpl4	2299	-567
Rpl5	767	2478
Rpl6	-669	-2330
Rpl7a	-2054	-3718
Rpl8	-4247	-3018
Rplp1	1737	1206
Rpn1	-584	-2591
Rpn2	2811	1591
Rps11	315	-2551
Rps12	2728	884
Rps13	-5050	-5764
Rps14	-1071	-1798
Rps15	-1045	-2489
Rps15a	-3231	-2769
Rps16	900	-494
Rps17	-4875	-5562
Rps19	-44	-2802
Rps20	2098	1064
Rps21	1421	-1394
Rps24	69	-130
Rps25	-2930	-2703
Rps27a	-1504	-1029
Rps27l	282	1037
Rps28	3137	-561
Rps3a1	-1317	-1655
Rps4x	810	-303
Rps5	1452	1852
Rps7	-2886	-1733
Rps8	1432	-1256
Rps9	-212	-1205
Rpsa	-3636	-3074
Sars2	-6953	-6965
Sec11a	2983	-1386
Sec11c	2545	-783
Sec61a1	6371	4324
Sec61a2	-4893	-5428
Sec61b	5315	1434
Sec61g	-4065	-1345
Spcs1	2963	780
Spcs2	1459	-541
Srp14	-2787	-1078
Srp19	-3428	-4816
Srp54a	-729	-3696
Srp68	-2008	-1774
Srp72	1277	-916
Srp9	-2636	-3551
Srpr	1234	-2564
Srprb	-2399	-694
Ssr1	6057	4618
Ssr2	2857	-2085
Ssr3	4310	-3996
Ssr4	1754	-2097
Tars	3361	754
Tars2	-6442	-5956
Tram1	6017	4182
Trmt112	390	1149
Tsfm	-6347	-6440
Tufm	-6846	-7363
Vars2	-6968	-6459
Wars2	-4658	-5948
Yars2	-6001	-7155

---

---

Protein-localization

Protein-localization

metric	value
setSize	142
pMANOVA	7.41e-29
p.adjustMANOVA	7.9e-27
s.dist	0.742
s.young	-0.512
s.old	-0.537
p.young	6.06e-26
p.old	2.04e-28

Top 20 genes

Gene	young	old
Ndufb8	-7343	-7800
Dhrs4	-7344	-7770
Timm23	-7335	-7749
Acot2	-7253	-7797
Phyh	-7261	-7709
Gstk1	-7200	-7732
Crat	-7321	-7591
Ech1	-7282	-7627
Cs	-7238	-7580
Atp5a1	-7220	-7504
Hspa9	-7037	-7692
Gnpat	-7105	-7547
Hspd1	-6966	-7697
Pxmp2	-6949	-7658
Grpel1	-7078	-7473
Idh3g	-7228	-7314
Ephx2	-6954	-7595
Atp5b	-7224	-7258
Cyc1	-7237	-7220
Slc25a4	-7089	-7295

Click HERE to show all gene set members

All member genes

	young	old
Abcd1	-6190	-6228
Abcd2	-5558	-4862
Abcd3	-6653	-7370
Acbd5	6712	4401
Aco2	-6436	-6977
Acot2	-7253	-7797
Acot4	825	-4529
Acot8	559	-172
Acox1	-4724	-7321
Acox3	1630	-3864
Agps	-605	-2899
Aldh3a2	-30	-948
Amacr	-6767	-7086
App	6494	6345
Atad1	-3794	-5152
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Bag6	-5266	-4082
Bcs1l	-5832	-6564
Caml	994	3005
Cat	-2626	-1549
Chchd10	-7262	-6494
Chchd2	-7180	-5992
Chchd3	-7066	-7212
Chchd5	-1580	-3461
Chchd7	-6825	-6448
Cmc2	-6667	-7225
Cmc4	-3869	1658
Coa4	-1599	348
Coa6	-4801	-4707
Coq2	-7039	-7275
Cox19	6674	6213
Crat	-7321	-7591
Crot	-1116	-3382
Cs	-7238	-7580
Cyb5a	4661	2737
Cyc1	-7237	-7220
Ddo	-5929	-5213
Decr2	-2640	-3902
Dhrs4	-7344	-7770
Ech1	-7282	-7627
Ehhadh	-5758	-7027
Emd	-2212	-1010
Ephx2	-6954	-7595
Fis1	-3956	-2973
Fxn	-6784	-6569
Get4	-1373	-1432
Gfer	-1953	-4416
Gm11808	-5706	-216
Gm45799	-1631	4287
Gnpat	-7105	-7547
Grpel1	-7078	-7473
Grpel2	-4955	-6528
Gstk1	-7200	-7732
Hmgcl	-6101	-4870
Hmox1	654	381
Hscb	-1609	-5700
Hsd17b4	-6387	-7282
Hspa9	-7037	-7692
Hspd1	-6966	-7697
Ide	-4424	-4327
Idh1	-3318	-6643
Idh3g	-7228	-7314
Ldhd	-6770	-7536
Lonp2	-5285	-6862
Mlycd	-6864	-7040
Mpv17	-5642	-5830
Mtx1	-5805	-4557
Mtx2	-6403	-6945
Ndufb8	-7343	-7800
Nos2	-5173	-6317
Nudt19	-6768	-6057
Nudt7	-6026	-7008
Pam16	-5409	-4217
Paox	3632	-605
Pecr	-5886	-6147
Pex1	-1700	-4722
Pex10	-6076	-6073
Pex11b	-3864	-5317
Pex12	2346	-4157
Pex13	-771	-5620
Pex14	809	-2777
Pex16	-3583	-3499
Pex19	-6534	-6309
Pex2	-5398	-6265
Pex26	-2597	-2650
Pex3	1333	-4235
Pex5	5993	2191
Pex6	-6267	-5589
Pex7	-6116	-6538
Phyh	-7261	-7709
Pipox	3254	2820
Pitrm1	-5821	-6104
Pmpca	-6712	-7102
Pmpcb	-5714	-7243
Prnp	7411	6404
Pxmp2	-6949	-7658
Pxmp4	-6593	-7236
Rps27a	-1504	-1029
Samm50	-7217	-6662
Scp2	-6736	-7268
Sec61b	5315	1434
Sec61g	-4065	-1345
Serp1	5557	2548
Sgta	-3667	-3548
Slc25a12	-7001	-7181
Slc25a13	-5896	-6938
Slc25a17	-336	-4956
Slc25a4	-7089	-7295
Stx1a	2912	1003
Stx5a	4418	3544
Taz	-5545	-5487
Timm10	-5933	-5648
Timm13	-5069	-2877
Timm17a	-6452	-6120
Timm17b	-2372	-4104
Timm21	-6376	-7056
Timm22	-3823	-5072
Timm23	-7335	-7749
Timm44	-7154	-7015
Timm50	-6322	-5800
Timm8b	-6609	-6897
Timm9	-5723	-5076
Tomm20	-4097	-410
Tomm22	-5748	-5300
Tomm40	-6658	-5282
Tomm6	-3900	-1449
Tomm7	-4071	-4401
Tomm70a	-5828	-6506
Tysnd1	-504	-3360
Ubb	5763	-1908
Ubc	-1436	-1699
Ube2d1	-4576	-5721
Ube2d2a	-681	-3716
Ube2d3	5709	3978
Ube2j2	-2625	-2495
Ubl4a	-5513	-5091
Usp9x	4374	-3676
Vamp2	-3875	-96
Vapa	441	-3564
Vdac1	-7008	-7195
Zfand6	-5659	-5819

---

---

Mitochondrial-protein-import

Mitochondrial-protein-import

metric	value
setSize	57
pMANOVA	8.67e-23
p.adjustMANOVA	8.53e-21
s.dist	1.03
s.young	-0.762
s.old	-0.686
p.young	2.29e-23
p.old	2.95e-19

Top 20 genes

Gene	young	old
Ndufb8	-7343	-7800
Timm23	-7335	-7749
Cs	-7238	-7580
Atp5a1	-7220	-7504
Hspa9	-7037	-7692
Hspd1	-6966	-7697
Grpel1	-7078	-7473
Idh3g	-7228	-7314
Atp5b	-7224	-7258
Cyc1	-7237	-7220
Slc25a4	-7089	-7295
Coq2	-7039	-7275
Ldhd	-6770	-7536
Chchd3	-7066	-7212
Vdac1	-7008	-7195
Slc25a12	-7001	-7181
Timm44	-7154	-7015
Cmc2	-6667	-7225
Samm50	-7217	-6662
Pmpca	-6712	-7102

Click HERE to show all gene set members

All member genes

	young	old
Aco2	-6436	-6977
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Bcs1l	-5832	-6564
Chchd10	-7262	-6494
Chchd2	-7180	-5992
Chchd3	-7066	-7212
Chchd5	-1580	-3461
Chchd7	-6825	-6448
Cmc2	-6667	-7225
Cmc4	-3869	1658
Coa4	-1599	348
Coa6	-4801	-4707
Coq2	-7039	-7275
Cox19	6674	6213
Cs	-7238	-7580
Cyc1	-7237	-7220
Fxn	-6784	-6569
Gfer	-1953	-4416
Gm45799	-1631	4287
Grpel1	-7078	-7473
Grpel2	-4955	-6528
Hscb	-1609	-5700
Hspa9	-7037	-7692
Hspd1	-6966	-7697
Idh3g	-7228	-7314
Ldhd	-6770	-7536
Mtx1	-5805	-4557
Mtx2	-6403	-6945
Ndufb8	-7343	-7800
Pam16	-5409	-4217
Pitrm1	-5821	-6104
Pmpca	-6712	-7102
Pmpcb	-5714	-7243
Samm50	-7217	-6662
Slc25a12	-7001	-7181
Slc25a13	-5896	-6938
Slc25a4	-7089	-7295
Taz	-5545	-5487
Timm10	-5933	-5648
Timm13	-5069	-2877
Timm17a	-6452	-6120
Timm17b	-2372	-4104
Timm21	-6376	-7056
Timm22	-3823	-5072
Timm23	-7335	-7749
Timm44	-7154	-7015
Timm50	-6322	-5800
Timm8b	-6609	-6897
Timm9	-5723	-5076
Tomm20	-4097	-410
Tomm22	-5748	-5300
Tomm40	-6658	-5282
Tomm6	-3900	-1449
Tomm7	-4071	-4401
Tomm70a	-5828	-6506
Vdac1	-7008	-7195

---

---

Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle

Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle

metric	value
setSize	51
pMANOVA	4.48e-21
p.adjustMANOVA	4.1e-19
s.dist	1.05
s.young	-0.725
s.old	-0.76
p.young	3.15e-19
p.old	5.37e-21

Top 20 genes

Gene	young	old
Adhfe1	-7349	-7821
Ldhb	-7348	-7811
Sdha	-7346	-7813
Sdhd	-7333	-7791
Sucla2	-7292	-7689
Mpc2	-7294	-7670
Suclg2	-7193	-7724
Idh3b	-7322	-7586
Dld	-7216	-7696
Suclg1	-7259	-7645
Dlst	-7165	-7693
Pdhx	-7172	-7679
Cs	-7238	-7580
Sdhb	-7295	-7485
Idh3a	-7085	-7634
Nnt	-6917	-7798
D2hgdh	-7104	-7565
Sdhc	-7227	-7405
Me3	-7147	-7472
Fahd1	-7052	-7556

Click HERE to show all gene set members

All member genes

	young	old
Aco2	-6436	-6977
Adhfe1	-7349	-7821
Bsg	-6548	-7267
Cs	-7238	-7580
D2hgdh	-7104	-7565
Dlat	-7003	-7332
Dld	-7216	-7696
Dlst	-7165	-7693
Fahd1	-7052	-7556
Fh1	-7115	-7449
Glo1	-5689	-5454
Gstz1	-6066	-6846
Hagh	3129	-1329
Idh2	-6961	-7381
Idh3a	-7085	-7634
Idh3b	-7322	-7586
Idh3g	-7228	-7314
L2hgdh	-6879	-7484
Ldha	3559	-4312
Ldhb	-7348	-7811
Mdh2	-7233	-7179
Me1	-6765	-6942
Me2	5856	4582
Me3	-7147	-7472
Mpc1	-7043	-7036
Mpc2	-7294	-7670
Nnt	-6917	-7798
Ogdh	-7013	-7475
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Pdk1	4156	-6364
Pdk2	-6889	-7055
Pdk3	6805	6440
Pdk4	-1655	1645
Pdp1	-4181	-5275
Pdp2	-5917	-7570
Pdpr	-5996	-7506
Ppard	-5588	-4490
Rxra	-6194	-6804
Sdha	-7346	-7813
Sdhb	-7295	-7485
Sdhc	-7227	-7405
Sdhd	-7333	-7791
Slc16a1	-5936	-4200
Slc16a3	7305	6044
Slc16a8	-4482	-3791
Sucla2	-7292	-7689
Suclg1	-7259	-7645
Suclg2	-7193	-7724
Vdac1	-7008	-7195

---

---

Mitochondrial-biogenesis

Mitochondrial-biogenesis

metric	value
setSize	88
pMANOVA	1.7e-19
p.adjustMANOVA	1.45e-17
s.dist	0.769
s.young	-0.53
s.old	-0.557
p.young	7.78e-18
p.old	1.67e-19

Top 20 genes

Gene	young	old
Sod2	-7345	-7817
Atp5o	-7347	-7794
Atp5l	-7340	-7690
Immt	-7219	-7621
Atp5pb	-7213	-7607
Atp5g3	-7235	-7573
Atp5a1	-7220	-7504
Atp5c1	-7207	-7515
Hspa9	-7037	-7692
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Apoo	-7092	-7482
Atp5b	-7224	-7258
Cycs	-7133	-7302
Idh2	-6961	-7381
mt-Atp6	-7229	-7101
Chchd3	-7066	-7212
Sirt5	-6878	-7374
Atp5j2	-7093	-7135
Ppara	-6545	-7563

Click HERE to show all gene set members

All member genes

	young	old
Acss2	-2290	-928
Alas1	-6613	-7012
Apoo	-7092	-7482
Apool	-5925	-6704
Atf2	-651	-5338
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Atp5c1	-7207	-7515
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5g3	-7235	-7573
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5j2	-7093	-7135
Atp5k	-5830	-7288
Atp5l	-7340	-7690
Atp5o	-7347	-7794
Atp5pb	-7213	-7607
Calm1	-4595	-4970
Carm1	-1701	-5594
Chchd3	-7066	-7212
Chchd6	-3301	-2838
Chd9	6475	5594
Creb1	-3517	-2558
Crebbp	-3332	-3533
Crtc1	4822	3316
Crtc2	2460	2533
Crtc3	3593	2639
Cycs	-7133	-7302
Dmac2l	-6520	-7171
Dnajc11	-6412	-6403
Esrra	-6804	-5371
Gabpa	-3716	-6288
Gabpb1	856	-2177
Glud1	-6306	-7705
Hcfc1	-2259	-3907
Hdac3	-6017	-6749
Helz2	-4511	2213
Hspa9	-7037	-7692
Idh2	-6961	-7381
Immt	-7219	-7621
Mapk11	704	-262
Mapk12	6483	6788
Mapk14	-6492	-6835
Med1	-2830	-5832
Mef2c	4484	1893
Mef2d	-4176	-241
Micos10	-7129	-6291
Micos13	-6641	-6011
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
Mterf1a	3165	-425
Mtx1	-5805	-4557
Mtx2	-6403	-6945
Ncoa1	-4484	-6419
Ncoa2	-3912	-6801
Ncoa6	-1555	-3479
Ncor1	-4730	-6152
Nr1d1	1296	-175
Nrf1	2046	1078
Perm1	-7027	-6909
Polg2	-3186	-2974
Polrmt	-6292	-5820
Ppara	-6545	-7563
Ppargc1a	-6363	-7511
Ppargc1b	-5894	-3355
Pprc1	3621	3813
Prkaa2	-6100	-7414
Prkab1	-4034	-7255
Prkab2	7420	5930
Prkag1	-6213	-4030
Prkag2	4029	-2192
Prkag3	5303	4957
Rxra	-6194	-6804
Samm50	-7217	-6662
Sirt3	-6560	-6988
Sirt4	-5710	-5696
Sirt5	-6878	-7374
Smarcd3	-4349	-759
Sod2	-7345	-7817
Ssbp1	-4608	-3399
Tbl1x	3008	-5102
Tbl1xr1	4225	-2715
Tfam	-6212	-6843
Tfb1m	-3569	-5783
Tfb2m	-6600	-7199
Tgs1	-4991	-5508
Tmem11	-5461	-4602

---

---

Collagen-biosynthesis-and-modifying-enzymes

Collagen-biosynthesis-and-modifying-enzymes

metric	value
setSize	56
pMANOVA	1.44e-17
p.adjustMANOVA	1.15e-15
s.dist	0.914
s.young	0.637
s.old	0.655
p.young	1.59e-16
p.old	2.1e-17

Top 20 genes

Gene	young	old
Col8a2	7452	6978
P3h2	7374	7030
Col8a1	7519	6875
Col5a2	7480	6907
Col12a1	7235	7031
Col16a1	7349	6856
Col1a2	7362	6786
Col14a1	7303	6796
Col4a3	7037	6967
Col11a1	7093	6902
Col27a1	7356	6638
Adamts2	7469	6535
Col4a5	7202	6747
Pcolce	7373	6528
Col4a4	7049	6807
Col1a1	7237	6629
Col9a2	7498	6397
P3h3	7230	6562
Col6a1	7176	6438
Col5a1	7233	6290

Click HERE to show all gene set members

All member genes

	young	old
Adamts14	3117	5979
Adamts2	7469	6535
Adamts3	-4916	-4222
Bmp1	7236	6255
Col11a1	7093	6902
Col11a2	-1021	3528
Col12a1	7235	7031
Col13a1	2636	3872
Col14a1	7303	6796
Col15a1	6814	6634
Col16a1	7349	6856
Col18a1	6116	5391
Col1a1	7237	6629
Col1a2	7362	6786
Col20a1	2825	6268
Col23a1	5725	2177
Col25a1	-1076	474
Col26a1	7193	5097
Col27a1	7356	6638
Col28a1	215	3053
Col3a1	6563	6455
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col4a5	7202	6747
Col4a6	2683	4540
Col5a1	7233	6290
Col5a2	7480	6907
Col5a3	2225	-2736
Col6a1	7176	6438
Col6a2	6971	6524
Col6a3	5781	6084
Col6a6	1479	-6594
Col8a1	7519	6875
Col8a2	7452	6978
Col9a2	7498	6397
Colgalt1	4060	2838
Colgalt2	-4035	-2084
Crtap	6718	3923
P3h1	6856	4702
P3h2	7374	7030
P3h3	7230	6562
P4ha1	4494	6389
P4ha2	-5915	-3841
P4ha3	6223	4289
P4hb	6441	4378
Pcolce	7373	6528
Pcolce2	3514	6586
Plod1	-2323	2388
Plod2	7080	6224
Plod3	5833	4938
Ppib	5989	3349
Serpinh1	1466	3868
Tll1	5403	4589
Tll2	-784	-5372

---

---

Cristae-formation

Cristae-formation

metric	value
setSize	29
pMANOVA	4.27e-17
p.adjustMANOVA	3.22e-15
s.dist	1.25
s.young	-0.905
s.old	-0.861
p.young	3.21e-17
p.old	9.79e-16

Top 20 genes

Gene	young	old
Atp5o	-7347	-7794
Atp5l	-7340	-7690
Immt	-7219	-7621
Atp5pb	-7213	-7607
Atp5g3	-7235	-7573
Atp5a1	-7220	-7504
Atp5c1	-7207	-7515
Hspa9	-7037	-7692
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Apoo	-7092	-7482
Atp5b	-7224	-7258
mt-Atp6	-7229	-7101
Chchd3	-7066	-7212
Atp5j2	-7093	-7135
Samm50	-7217	-6662
Dmac2l	-6520	-7171
Atp5d	-7173	-6303
Micos10	-7129	-6291
Mtx2	-6403	-6945

Click HERE to show all gene set members

All member genes

	young	old
Apoo	-7092	-7482
Apool	-5925	-6704
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Atp5c1	-7207	-7515
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5g3	-7235	-7573
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5j2	-7093	-7135
Atp5k	-5830	-7288
Atp5l	-7340	-7690
Atp5o	-7347	-7794
Atp5pb	-7213	-7607
Chchd3	-7066	-7212
Chchd6	-3301	-2838
Dmac2l	-6520	-7171
Dnajc11	-6412	-6403
Hspa9	-7037	-7692
Immt	-7219	-7621
Micos10	-7129	-6291
Micos13	-6641	-6011
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
Mtx1	-5805	-4557
Mtx2	-6403	-6945
Samm50	-7217	-6662
Tmem11	-5461	-4602

---

---

Mitochondrial-Fatty-Acid-Beta-Oxidation

Mitochondrial-Fatty-Acid-Beta-Oxidation

metric	value
setSize	31
pMANOVA	5.13e-17
p.adjustMANOVA	3.65e-15
s.dist	1.21
s.young	-0.858
s.old	-0.85
p.young	1.25e-16
p.old	2.49e-16

Top 20 genes

Gene	young	old
Hadh	-7309	-7774
Acaa2	-7293	-7768
Eci1	-7341	-7716
Hadhb	-7300	-7759
Acot2	-7253	-7797
Decr1	-7267	-7777
Echs1	-7313	-7662
Hadha	-7254	-7673
Ndufab1	-7247	-7579
Acad11	-7134	-7691
Acadvl	-7306	-7500
Acadm	-7198	-7598
Mmut	-7065	-7739
Pcca	-7022	-7738
Mcee	-7015	-7616
Acads	-7280	-7250
Pccb	-7054	-7359
Acadl	-6920	-7478
Acot13	-7060	-7028
Acot11	-6459	-7215

Click HERE to show all gene set members

All member genes

	young	old
Acaa2	-7293	-7768
Acad11	-7134	-7691
Acad12	-6749	-6851
Acadl	-6920	-7478
Acadm	-7198	-7598
Acads	-7280	-7250
Acadvl	-7306	-7500
Acbd6	-5225	-2979
Acot11	-6459	-7215
Acot13	-7060	-7028
Acot2	-7253	-7797
Acot7	-5971	-6960
Acot9	7045	6582
Acsf2	-5910	-7231
Dbi	-6324	-6808
Decr1	-7267	-7777
Echs1	-7313	-7662
Eci1	-7341	-7716
Hadh	-7309	-7774
Hadha	-7254	-7673
Hadhb	-7300	-7759
Mcat	-6474	-6636
Mcee	-7015	-7616
Mecr	-6170	-6438
Mmaa	-6691	-6758
Mmut	-7065	-7739
Ndufab1	-7247	-7579
Pcca	-7022	-7738
Pccb	-7054	-7359
Pctp	-3512	-6069
Them4	-5770	-5601

---

---

Collagen-formation

Collagen-formation

metric	value
setSize	75
pMANOVA	1.22e-16
p.adjustMANOVA	8.24e-15
s.dist	0.769
s.young	0.546
s.old	0.542
p.young	3.06e-16
p.old	4.96e-16

Top 20 genes

Gene	young	old
Col8a2	7452	6978
P3h2	7374	7030
Col8a1	7519	6875
Col5a2	7480	6907
Lamc2	7360	6977
Col12a1	7235	7031
Col16a1	7349	6856
Loxl2	7336	6852
Loxl3	7361	6821
Col1a2	7362	6786
Col14a1	7303	6796
Col4a3	7037	6967
Col11a1	7093	6902
Col27a1	7356	6638
Adamts2	7469	6535
Col4a5	7202	6747
Pcolce	7373	6528
Col4a4	7049	6807
Col1a1	7237	6629
Col9a2	7498	6397

Click HERE to show all gene set members

All member genes

	young	old
Adamts14	3117	5979
Adamts2	7469	6535
Adamts3	-4916	-4222
Bmp1	7236	6255
Cd151	-3387	-2499
Col11a1	7093	6902
Col11a2	-1021	3528
Col12a1	7235	7031
Col13a1	2636	3872
Col14a1	7303	6796
Col15a1	6814	6634
Col16a1	7349	6856
Col18a1	6116	5391
Col1a1	7237	6629
Col1a2	7362	6786
Col20a1	2825	6268
Col23a1	5725	2177
Col25a1	-1076	474
Col26a1	7193	5097
Col27a1	7356	6638
Col28a1	215	3053
Col3a1	6563	6455
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col4a5	7202	6747
Col4a6	2683	4540
Col5a1	7233	6290
Col5a2	7480	6907
Col5a3	2225	-2736
Col6a1	7176	6438
Col6a2	6971	6524
Col6a3	5781	6084
Col6a6	1479	-6594
Col8a1	7519	6875
Col8a2	7452	6978
Col9a2	7498	6397
Colgalt1	4060	2838
Colgalt2	-4035	-2084
Crtap	6718	3923
Ctsb	-39	-2241
Ctss	3818	-193
Dst	5571	5573
Itga6	-5055	-3078
Itgb4	2528	3814
Lama3	1858	-436
Lamb3	-6638	-7066
Lamc2	7360	6977
Lox	7364	6358
Loxl1	7313	5950
Loxl2	7336	6852
Loxl3	7361	6821
Loxl4	6831	6223
Mmp13	-101	-5501
Mmp3	-1265	4045
Mmp9	1226	-6359
P3h1	6856	4702
P3h2	7374	7030
P3h3	7230	6562
P4ha1	4494	6389
P4ha2	-5915	-3841
P4ha3	6223	4289
P4hb	6441	4378
Pcolce	7373	6528
Pcolce2	3514	6586
Plec	1669	2349
Plod1	-2323	2388
Plod2	7080	6224
Plod3	5833	4938
Ppib	5989	3349
Pxdn	-3621	-6204
Serpinh1	1466	3868
Tll1	5403	4589
Tll2	-784	-5372

---

---

Collagen-chain-trimerization

Collagen-chain-trimerization

metric	value
setSize	33
pMANOVA	1.12e-13
p.adjustMANOVA	7.15e-12
s.dist	1.04
s.young	0.737
s.old	0.74
p.young	2.34e-13
p.old	1.79e-13

Top 20 genes

Gene	young	old
Col8a2	7452	6978
Col8a1	7519	6875
Col5a2	7480	6907
Col12a1	7235	7031
Col16a1	7349	6856
Col1a2	7362	6786
Col14a1	7303	6796
Col4a3	7037	6967
Col11a1	7093	6902
Col27a1	7356	6638
Col4a5	7202	6747
Col4a4	7049	6807
Col1a1	7237	6629
Col9a2	7498	6397
Col6a1	7176	6438
Col5a1	7233	6290
Col6a2	6971	6524
Col15a1	6814	6634
Col3a1	6563	6455
Col26a1	7193	5097

Click HERE to show all gene set members

All member genes

	young	old
Col11a1	7093	6902
Col11a2	-1021	3528
Col12a1	7235	7031
Col13a1	2636	3872
Col14a1	7303	6796
Col15a1	6814	6634
Col16a1	7349	6856
Col18a1	6116	5391
Col1a1	7237	6629
Col1a2	7362	6786
Col20a1	2825	6268
Col23a1	5725	2177
Col25a1	-1076	474
Col26a1	7193	5097
Col27a1	7356	6638
Col28a1	215	3053
Col3a1	6563	6455
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col4a5	7202	6747
Col4a6	2683	4540
Col5a1	7233	6290
Col5a2	7480	6907
Col5a3	2225	-2736
Col6a1	7176	6438
Col6a2	6971	6524
Col6a3	5781	6084
Col6a6	1479	-6594
Col8a1	7519	6875
Col8a2	7452	6978
Col9a2	7498	6397

---

---

Citric-acid-cycle-(TCA-cycle)

Citric-acid-cycle-(TCA-cycle)

metric	value
setSize	22
pMANOVA	2.51e-13
p.adjustMANOVA	1.53e-11
s.dist	1.26
s.young	-0.894
s.old	-0.889
p.young	3.71e-13
p.old	5.02e-13

Top 20 genes

Gene	young	old
Sdha	-7346	-7813
Sdhd	-7333	-7791
Sucla2	-7292	-7689
Suclg2	-7193	-7724
Idh3b	-7322	-7586
Dld	-7216	-7696
Suclg1	-7259	-7645
Dlst	-7165	-7693
Cs	-7238	-7580
Sdhb	-7295	-7485
Idh3a	-7085	-7634
Nnt	-6917	-7798
Sdhc	-7227	-7405
Me3	-7147	-7472
Fahd1	-7052	-7556
Fh1	-7115	-7449
Idh3g	-7228	-7314
Ogdh	-7013	-7475
Mdh2	-7233	-7179
Idh2	-6961	-7381

Click HERE to show all gene set members

All member genes

	young	old
Aco2	-6436	-6977
Cs	-7238	-7580
Dld	-7216	-7696
Dlst	-7165	-7693
Fahd1	-7052	-7556
Fh1	-7115	-7449
Idh2	-6961	-7381
Idh3a	-7085	-7634
Idh3b	-7322	-7586
Idh3g	-7228	-7314
Mdh2	-7233	-7179
Me2	5856	4582
Me3	-7147	-7472
Nnt	-6917	-7798
Ogdh	-7013	-7475
Sdha	-7346	-7813
Sdhb	-7295	-7485
Sdhc	-7227	-7405
Sdhd	-7333	-7791
Sucla2	-7292	-7689
Suclg1	-7259	-7645
Suclg2	-7193	-7724

---

---

Signal-Transduction

Signal-Transduction

metric	value
setSize	1697
pMANOVA	3.11e-13
p.adjustMANOVA	1.81e-11
s.dist	0.144
s.young	0.113
s.old	0.0899
p.young	3.26e-14
p.old	1.55e-09

Top 20 genes

Gene	young	old
Stk4	7525	7053
Rtn4	7507	7050
Rhoc	7516	7014
Gnao1	7515	7001
Ncam1	7473	7015
Ngef	7494	6990
Lrp8	7444	7007
Fstl3	7499	6931
Thbs4	7358	7046
Arhgap22	7429	6969
Cilp	7513	6887
Chn2	7418	6971
Mmp2	7497	6885
Arhgap11a	7394	6962
Lamc2	7360	6977
Adcy7	7472	6866
Fzd2	7468	6862
F2r	7423	6894
Fzd7	7316	6985
Srgap3	7276	7005

Click HERE to show all gene set members

All member genes

	young	old
A2m	6437	1719
Aatf	1620	2893
Abca1	5067	-281
Abca4	-6708	103
Abcg1	4372	4144
Abhd12	-138	-2637
Abhd6	-3892	-5847
Abi1	4624	4991
Abi2	5344	5667
Abl1	-3295	-1044
Abr	-3993	-4645
Ackr2	6213	5741
Ackr3	-5232	-1642
Ackr4	7184	5570
Acta2	-5838	3002
Actb	662	-310
Actg1	-1363	880
Actn2	-2000	-1053
Actr2	3943	842
Actr3	6464	4364
Acvr1b	-603	-3711
Acvr2a	1476	-990
Acvr2b	-3633	-5605
Acvrl1	-4389	-2410
Adam10	5268	3108
Adam12	5421	4313
Adam17	289	-1999
Adap1	7089	6608
Adcy1	-6563	-7364
Adcy2	5556	5860
Adcy3	4131	2305
Adcy4	-5866	-4935
Adcy5	2555	4612
Adcy6	-5219	-4103
Adcy7	7472	6866
Adcy9	-4881	-5347
Adcyap1r1	6532	3664
Adgre1	2280	181
Adh1	-6458	-7736
Adm	2893	-1321
Adora1	-4092	5269
Adora2a	-2137	-6664
Adora3	-675	-1055
Adra1a	-7031	-7809
Adra1b	-5165	-5348
Adra1d	-402	-1465
Adra2b	-6086	-1031
Adra2c	-1945	2287
Adrb1	-5580	-6094
Adrb2	-1509	-2331
Ago1	2166	-963
Ago2	2186	-155
Ago3	-1778	-2978
Ago4	-4949	-7303
Agrn	-247	199
Agt	-4320	-6233
Ahctf1	-1327	1125
Ahcyl1	366	-4646
Akap13	6625	6751
Akr1b8	6176	5778
Akt1	-6210	-5765
Akt1s1	-319	-2179
Akt2	-7113	-6780
Akt3	2614	4706
Aldh1a2	5436	-3233
Aldh1a3	6915	6545
Aldh8a1	696	1793
Amer1	6232	5260
Amot	6138	5596
Amotl1	838	4479
Amotl2	-5325	-5232
Angpt1	-7088	-7650
Angptl3	-5745	-957
Anxa1	7137	6423
Ap2a1	4766	-1188
Ap2a2	1207	-4356
Ap2b1	5061	4756
Ap2m1	1964	309
Ap2s1	1934	322
Apbb1ip	6482	6202
Apc	6673	5921
Aph1a	-4147	-4136
Aph1b	-1630	-4351
Apln	-6291	-7317
Aplnr	-5034	-2393
Apoa1	-3117	-370
Apoa2	-4104	-1788
Apob	-2312	1254
Apoc4	-4988	2472
Apod	6634	6993
Apoe	948	-334
App	6494	6345
Ar	594	2654
Araf	-4959	-2947
Arap1	5954	3831
Arap2	-1350	-4921
Arap3	-5858	-5809
Arf6	5964	4802
Arhgap1	5837	3387
Arhgap10	-5360	-3726
Arhgap11a	7394	6962
Arhgap12	-506	800
Arhgap15	-1596	408
Arhgap17	-1015	2460
Arhgap18	-3552	-6179
Arhgap19	2030	-5976
Arhgap20	-5001	-6586
Arhgap21	3599	289
Arhgap22	7429	6969
Arhgap23	3516	4484
Arhgap24	-1360	870
Arhgap25	-1759	-4768
Arhgap26	-6349	-7597
Arhgap27	-2412	2882
Arhgap28	2083	-4075
Arhgap29	-5020	-6589
Arhgap30	1008	-823
Arhgap31	-5344	-3982
Arhgap32	6908	4381
Arhgap33	4606	5492
Arhgap35	4198	5153
Arhgap39	1536	1625
Arhgap4	663	1775
Arhgap42	-1161	-2286
Arhgap44	7180	6263
Arhgap5	-2948	-5451
Arhgap6	6646	5509
Arhgap8	-3105	-271
Arhgap9	-3502	-6243
Arhgdia	4925	3516
Arhgdib	961	1065
Arhgdig	7025	6168
Arhgef1	1955	1042
Arhgef10	-2971	1396
Arhgef10l	7155	5662
Arhgef11	1968	-3385
Arhgef12	5941	5958
Arhgef15	-6503	-6246
Arhgef16	-1902	-413
Arhgef17	-4717	-866
Arhgef18	1393	4450
Arhgef19	-5697	-6545
Arhgef2	2328	5021
Arhgef25	6853	-3652
Arhgef26	-529	444
Arhgef3	-4871	-2937
Arhgef37	-1783	-1494
Arhgef39	5410	6824
Arhgef4	3028	-1582
Arhgef40	7409	6589
Arhgef5	2848	6152
Arhgef6	4069	1220
Arhgef7	863	-4668
Arhgef9	-5499	-6454
Arl4c	3666	5581
Arpc1a	1275	-1289
Arpc1b	5865	3747
Arpc2	6342	4176
Arpc3	4578	4114
Arpc4	5956	2991
Arpc5	5253	3164
Arrb1	6454	5029
Arrb2	2854	2025
Ash2l	1009	3931
Atf1	4185	1632
Atf2	-651	-5338
Atp2a2	-6892	-7466
Atp2a3	-769	2193
Atp6ap1	1328	2557
Atp6v0a1	-3987	-5623
Atp6v0a2	-734	-6476
Atp6v0a4	6941	6919
Atp6v0b	-3815	-2262
Atp6v0c	-1692	-715
Atp6v0d1	307	-2150
Atp6v0e	4446	4738
Atp6v0e2	6287	6347
Atp6v1a	1883	3522
Atp6v1b2	-5684	-5506
Atp6v1c1	458	-2347
Atp6v1d	-5814	-6408
Atp6v1e1	-4082	-4381
Atp6v1f	527	-3203
Atp6v1g1	-5352	-5782
Atp6v1g2	5757	1618
Atp6v1h	6538	6604
Aurkb	3210	3991
Avpr1a	-5760	-6645
Axin1	3573	2919
Axin2	5432	6015
Axl	7445	6311
B4galt1	3267	1068
B9d2	1247	-1120
Bad	4020	3510
Bag4	396	-1463
Baiap2	7195	6654
Bambi	7048	6497
Bax	5258	3874
Bcar1	7122	5122
Bcl2	7330	6782
Bcl2l11	-4296	-6286
Bcl9	-4024	-4681
Bcl9l	3669	-1114
Bcr	4983	5060
Bdnf	-1575	-6180
Bex3	3243	384
Birc2	-3354	-4484
Birc3	5640	1352
Birc5	2583	4194
Bmi1	-6397	-6220
Bmp2	-2270	2145
Bmpr1a	3149	3437
Bmpr2	4898	4305
Boc	2625	6100
Braf	-1243	2714
Brap	5029	2606
Brk1	1129	286
Btc	3998	3938
Btk	-2061	-2454
Btrc	-983	-2965
Bub1	1105	4517
Bub3	-1705	-546
C3	-1415	-6719
C3ar1	2000	1897
C5ar1	-146	-1606
C5ar2	194	-3216
Cab39	5066	4406
Cab39l	-765	-832
Calcrl	5853	3332
Calm1	-4595	-4970
Camk2a	-6445	-7293
Camk2b	7071	5898
Camk2g	-3829	-6080
Camkk1	6373	6639
Camkk2	6852	5301
Camkmt	-1938	143
Carm1	-1701	-5594
Casp2	160	3626
Casp3	6837	4230
Casp8	-791	-3340
Casp9	3738	-2865
Cav1	-5892	-7143
Cav2	-5844	-5876
Cbfb	5644	4451
Cbl	2363	821
Cbx2	3715	1391
Cbx4	1789	2079
Cbx6	6773	5589
Cbx8	-714	-3048
Cby1	-3612	-3102
Ccdc88c	-3948	679
Ccl2	2195	-4721
Ccl7	3952	-5153
Ccl9	-6741	-6922
Ccnc	3190	2238
Ccnd1	2065	4489
Ccnd3	3954	2791
Ccne1	3855	1801
Ccnk	-4488	-3894
Ccnt1	-3985	-5875
Ccnt2	-4162	-1870
Ccr1	4784	1307
Ccr10	1614	1451
Ccr2	5608	-3576
Ccr5	126	20
Ccrl2	-5124	-6524
Cd28	-2942	-5027
Cd80	2093	2902
Cd86	1115	-91
Cdc14a	4536	-955
Cdc20	1433	3116
Cdc37	-6143	-4147
Cdc42	4331	3497
Cdc42ep2	-1584	986
Cdc42ep3	-3193	-4296
Cdc42ep5	6014	4074
Cdc73	61	-1350
Cdca8	5325	3945
Cdh5	-4444	-6560
Cdk1	5710	3875
Cdk2	-2220	-2606
Cdk4	3801	980
Cdk5	-807	351
Cdk5r1	3200	5364
Cdk8	6754	5462
Cdk9	5136	3255
Cdkn1a	5001	5540
Cdkn1b	-1220	-5514
Cdkn2b	6506	4830
Cdon	6605	5408
Cenpa	-3479	-2363
Cenpc1	1078	2436
Cenpe	6429	5244
Cenpf	-6022	-6794
Cenpi	3894	101
Cenpl	3823	-1277
Cenpn	2680	1267
Cenpo	4399	3542
Cenpp	-814	3895
Cenpq	1164	-2232
Cenpt	4599	4429
Cfl1	2263	2403
Cflar	-4133	-2358
Chd1	4958	4934
Chd3	-4325	-6065
Chd4	5309	4887
Chd8	1558	1370
Chek1	1067	3898
Chn1	3840	4046
Chn2	7418	6971
Chrdl1	742	2722
Chrm2	-3866	-3729
Chrm3	225	-2399
Chuk	-1279	-2202
Cilp	7513	6887
Cit	522	2535
Ckap5	1514	-5473
Clasp1	-5646	-7348
Clasp2	-3925	-6410
Clip1	6553	5480
Clip3	7194	5627
Clta	2287	-631
Cltb	6447	5854
Cltc	2485	6
Cma1	988	82
Cmklr1	5841	5982
Cngb1	-3825	-2720
Cnksr1	7375	6771
Cnksr2	5134	6459
Cnot6l	-3465	-624
Cnr2	-3729	-2819
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col4a5	7202	6747
Col6a1	7176	6438
Col6a2	6971	6524
Col6a3	5781	6084
Col6a6	1479	-6594
Col9a2	7498	6397
Cpt1a	3375	-3304
Cpt1b	-6751	-7032
Creb1	-3517	-2558
Crebbp	-3332	-3533
Crhr2	-7109	-7742
Crk	-1529	-945
Crkl	-2538	-3934
Csf2ra	6263	4780
Csf2rb2	4887	3245
Csk	384	-1162
Csnk1a1	92	-2196
Csnk1e	2484	-2792
Csnk1g2	-1867	-1025
Csnk2a1	-6837	-7714
Csnk2a2	2827	-156
Csnk2b	-4627	-5569
Ctbp1	-4329	-4109
Ctbp2	-993	671
Ctnna1	-4995	-5073
Ctnnb1	-2555	-3976
Ctnnbip1	2189	5245
Cttn	7225	6511
Cul1	-3119	-3855
Cul3	-3349	-6313
Cul5	-2055	-6542
Cx3cl1	5319	4905
Cx3cr1	2594	4915
Cxcl10	6404	6503
Cxcl12	-2702	-7116
Cxcl16	6525	4852
Cxcl9	-5835	-4523
Cxcr4	-5386	-5393
Cxcr6	7346	5824
Cxxc4	722	-2921
Cxxc5	6265	-8
Cyba	629	-1455
Cybb	3394	-2359
Cyfip1	2165	-1240
Cyfip2	-7188	-7751
Cyld	7081	5831
Cyp26b1	-5413	-5234
Cyp4v3	1947	2922
Cysltr1	6679	5775
Daam1	-5306	-7072
Dab2ip	-4902	-2523
Dact1	5775	5214
Dagla	5405	2618
Daglb	6108	5773
Ddx5	-4166	-1868
Depdc7	1606	-5541
Derl2	-2315	-4575
Dgka	-4870	-4501
Dgkb	2754	4349
Dgkd	5922	5645
Dgke	-6208	-5221
Dgkg	-2589	6777
Dgkh	-4773	-3197
Dgkq	-3202	728
Dgkz	-5865	-1113
Dhh	-3543	2164
Dhrs3	-5679	-4372
Dhrs4	-7344	-7770
Dhrs9	4412	6006
Diaph1	4594	4855
Diaph2	3005	1306
Diaph3	5587	5434
Dlat	-7003	-7332
Dlc1	-5330	-7004
Dld	-7216	-7696
Dlg1	1311	-1704
Dlg2	7058	6995
Dlg3	4869	4306
Dlg4	6131	5964
Dlgap5	3580	4431
Dll1	-3529	-4435
Dll4	-6237	-6376
Dnajb1	-2400	-2076
Dnal4	-1934	-3240
Dnm1	7467	6740
Dnm2	-4130	324
Dnm3	-1732	3166
Dock1	5365	5455
Dock7	6978	5868
Dok1	6312	6298
Drap1	-4038	-1295
Drd2	-1769	580
Dsn1	5243	4832
Dtx1	-900	-1346
Dtx2	4257	5185
Dtx4	6187	-2058
Dusp1	-2842	864
Dusp10	6471	6681
Dusp16	-2466	-2042
Dusp2	6530	6313
Dusp4	6639	6060
Dusp5	5873	4069
Dusp6	3733	4564
Dusp7	-6051	-6519
Dusp8	-5958	-5321
Dvl1	-376	452
Dvl2	5014	-1883
Dvl3	-1856	-6070
Dync1h1	2619	4531
Dync1i2	5203	4439
Dync1li1	6485	5683
Dync1li2	4461	5015
Dync2h1	5678	6391
Dynll1	5075	5782
Dynll2	-6128	-5510
Dzip1	6296	6014
E2f1	4237	5630
E2f3	6585	6156
E2f4	-2332	-872
E2f5	4814	-2248
Ebag9	-4006	-5538
Ece1	3209	-4159
Ece2	6648	3574
Ect2	5210	4175
Edn1	6861	48
Edn3	6366	6744
Ednra	-5789	-7177
Ednrb	5957	-819
Eed	-1278	-3292
Eef2k	-1766	-5422
Eepd1	-6325	-6327
Efcab7	3598	3928
Egf	-5607	-6796
Egfr	6827	4231
Egr1	6800	2934
Eif4e	-5795	-5062
Eif4ebp1	-2737	-1088
Eif4g1	-5508	-5906
Elk1	730	-4144
Elmo1	3041	6905
Elmo2	4648	-559
Ep300	-2809	-454
Epas1	-5094	-7186
Epn1	-6564	-4868
Epor	688	-3210
Eps15	4596	4742
Eps15l1	-5775	-6626
Erbb2	6225	5682
Erbb3	-4416	-6276
Erbb4	-4933	-5991
Erbin	6930	6090
Ercc6l	1344	991
Ereg	7082	6195
Erlec1	29	-3423
Esr1	-3962	1501
Etv4	7385	6727
Evc	6657	6361
Evc2	6445	6114
Evl	-2001	-3400
Ezh2	1073	-2112
F11r	-352	-4343
F2r	7423	6894
F2rl1	2530	5665
F2rl3	-645	631
Fabp5	-285	-5130
Fadd	3556	-919
Fam13a	6418	6692
Fam13b	6199	6106
Fas	-4946	-4767
Fasn	4789	4808
Fbxw7	-1767	3232
Fcer2a	-2480	2509
Fer	-818	-1503
Fes	-2403	431
Fga	-3043	855
Fgb	-3889	1327
Fgd1	6243	1048
Fgd2	323	-1605
Fgd3	-434	6342
Fgd4	-5662	-4952
Fgf1	-6409	-6042
Fgf16	-6944	-7284
Fgf18	880	3645
Fgf2	3347	-4613
Fgf6	5190	6275
Fgf7	689	-852
Fgf9	-5418	-6966
Fgfbp3	-3463	-449
Fgfr1	7453	6618
Fgfr2	6924	4659
Fgfr3	-204	6111
Fgfrl1	6005	2633
Fkbp1a	6714	3954
Fkbp4	-7204	-7508
Fkbp5	4337	3812
Flna	-813	4118
Flrt2	6514	6338
Flrt3	-29	649
Flt1	-4698	-6777
Flt3l	3362	6123
Flt4	2005	2622
Fmnl1	-6681	-3942
Fmnl2	716	5597
Fmnl3	3760	6033
Fn1	7320	6491
Fnta	-2838	-2939
Fntb	-4346	-1943
Fos	7050	4530
Fosb	6922	3434
Foxo1	2248	-1056
Foxo3	-3836	-5969
Foxo4	-4257	-3546
Foxo6	-2013	-6019
Frat1	102	-6191
Frat2	-335	-2487
Frk	5329	4846
Frs2	-218	-3918
Frs3	-1740	-3924
Fst	4288	373
Fstl1	7372	6531
Fstl3	7499	6931
Furin	1738	-2954
Fuz	-3225	-1591
Fyn	-1763	2161
Fzd1	7072	6494
Fzd2	7468	6862
Fzd3	2650	-4881
Fzd4	-3807	-5670
Fzd5	977	-1199
Fzd6	-1643	-4715
Fzd7	7316	6985
Fzd8	-1650	-3004
Fzd9	1646	-2212
Gab1	3288	-4110
Gab2	7094	6805
Gabbr1	4583	5504
Gabrb3	5080	5081
Gas1	5126	5459
Gas8	1183	3535
Gata3	-2641	-1970
Gatad2a	1054	676
Gatad2b	3885	-2689
Gdi1	-1923	2493
Gdi2	5610	3130
Gdnf	2508	4885
Gfra1	-7074	-7437
Gfra2	3155	-3765
Gfra3	-846	-456
Gfra4	-6610	-7277
Gga3	-4565	-2465
Gli1	2934	3910
Gli2	7223	6627
Gli3	6061	4985
Gm11808	-5706	-216
Gm45234	3083	-316
Gm45837	631	778
Gmip	3772	3815
Gna11	-4353	-3900
Gna12	-4539	-6255
Gna13	6652	5922
Gna15	-635	-2576
Gnai1	6499	6092
Gnai2	3854	1841
Gnai3	5056	4344
Gnal	5955	6980
Gnao1	7515	7001
Gnas	5370	2987
Gnaz	1216	906
Gnb1	3378	553
Gnb2	2426	-280
Gnb3	-4309	-7248
Gnb4	4703	4055
Gnb5	-739	-4170
Gng10	3588	3127
Gng11	-2381	-3084
Gng12	2443	-1045
Gng2	2834	1842
Gng8	6555	5926
Gngt2	-3723	-2987
Gnrh1	-1699	-2260
Gopc	5501	4340
Gpam	-6358	-7122
Gpc1	-3801	-4293
Gpc3	2127	-5769
Gpc4	-3619	-6582
Gpc6	6891	6273
Gper1	-743	-562
Gpihbp1	-3847	-6453
Gpnmb	4028	6379
Gpr161	6533	5887
Gpr17	-4163	5053
Gpr176	5805	4692
Gpr183	-490	-318
Gpr20	-768	-1135
Gpr27	-3766	-6963
Gpr35	6012	3352
Gpr39	6659	6445
Gpr4	-4543	-5848
Gpr65	110	3741
Gpr68	5020	3200
Gps2	-776	1748
Gpsm1	-6824	-6238
Gpsm2	6631	4605
Gpsm3	5447	3802
Grap2	2695	280
Grb10	6111	390
Grb2	-4590	-3819
Greb1	6706	6791
Grin2d	5624	-588
Grk1	1631	-956
Grk2	-5236	-5006
Grk3	2707	2012
Grk4	6284	5580
Grk5	7171	6880
Grk6	-4193	-3621
Grm1	-6999	-7737
Gsk3a	-4423	-3666
Gsk3b	6419	5572
Gtf2a1	6650	3971
Gtf2a2	-4702	-5681
Gtf2f1	-1213	1075
Gtf2f2	234	-545
Guca1b	1449	3791
H3f3a	-2808	-2666
Hbegf	7493	6774
Hdac1	5275	3944
Hdac10	-626	1621
Hdac11	-6797	-7439
Hdac2	-4789	-5887
Hdac3	-6017	-6749
Hdac4	-3163	-4830
Hdac5	-4695	-2540
Hdac6	6751	5144
Hdac7	-3802	-822
Hdac8	5046	1861
Hdac9	6050	4630
Hebp1	6067	5275
Hes1	4367	-195
Hey1	-4523	-5707
Hey2	-3980	-5989
Heyl	6892	5225
Hgf	4186	1759
Hgs	4975	3859
Hhat	5690	4537
Hif1a	6604	1121
Hnrnpa1	4679	4990
Hnrnpf	-1883	-3953
Hnrnph1	-2402	-2388
Hnrnpm	-2565	-5210
Hpn	-4359	-4725
Hras	-3767	-1016
Hrh2	-2160	-1414
Hsp90ab1	-3870	-989
Hspb1	7446	6787
Hspg2	6535	3769
Htr2a	3479	6543
Ier3	5131	3998
Ift122	1483	5861
Ift140	4747	135
Ift172	-3401	-3674
Ift52	770	-3123
Ift57	5681	5554
Ift88	4582	2773
Igf1	7240	5920
Igf1r	6747	6611
Igf2	768	-5914
Ikbkb	2795	5196
Ikbkg	-3327	-2281
Ikzf1	-357	-385
Il17rd	6004	6217
Il1rap	6417	5028
Il1rl1	-2719	-2986
Il2ra	-5927	-4866
Il2rb	2395	3790
Il2rg	-3503	-3948
Il33	5215	4653
Il6ra	-1025	-4610
Il6st	6220	5168
Incenp	3287	3181
Inhba	7150	6998
Inhbb	4233	-3243
Inpp5b	1011	-1466
Insr	-2006	-4919
Intu	4641	4309
Iqgap1	5787	6617
Iqgap2	-997	-3650
Iqgap3	6649	6994
Irak1	-4897	-4749
Irs1	4191	4325
Irs2	-2191	121
Itch	727	360
Itga2	3765	6228
Itga2b	5803	437
Itga3	5715	5066
Itgav	7314	6700
Itgb1	6770	5825
Itgb3	7496	5721
Itgb3bp	-1539	-74
Itpr1	-3696	1181
Itpr2	-1813	4665
Itpr3	-366	4557
Itsn1	946	-1939
Jag1	-1325	-2297
Jag2	-6220	-6092
Jak1	-2505	-6853
Jak2	2955	-1644
Jak3	3030	-3812
Jun	7154	4510
Junb	7156	4999
Jund	4164	4065
Jup	929	-1298
Kalrn	5103	5543
Kank1	6962	5070
Kat2a	-2729	-1556
Kat2b	316	-3888
Kat5	4443	1393
Kbtbd7	4438	5031
Kctd6	1255	4607
Kdm1a	6403	4668
Kdm1b	-2404	-4878
Kdm3a	3887	5219
Kdm4a	-3474	-6051
Kdm4b	972	1387
Kdm4c	1265	450
Kdr	-5777	-7016
Khdrbs1	4543	1476
Khdrbs2	-685	1366
Khdrbs3	-7162	-7585
Kidins220	799	-1911
Kif14	466	1803
Kif18a	5407	4955
Kif2a	6321	-1561
Kif2c	5287	3465
Kif3a	4134	6220
Kif5a	504	2105
Kif5b	6829	6240
Kif7	5782	3159
Kiss1r	2433	-970
Kit	-1426	-3358
Kitl	-6423	1329
Klc1	5054	5911
Klc2	-5210	-4500
Klc4	774	-2078
Klhl12	-4013	-4893
Kmt2d	-4865	-3749
Knl1	5392	5248
Kntc1	4187	4735
Kpna2	-4477	-5690
Kras	-2032	-4043
Kremen1	7220	5810
Ksr1	-1068	-1758
Ktn1	3908	-169
Lama2	7478	6628
Lama3	1858	-436
Lama4	3147	2662
Lama5	5048	-4782
Lamb1	6771	-983
Lamb2	2375	4485
Lamb3	-6638	-7066
Lamc1	7347	5936
Lamc2	7360	6977
Lamc3	6611	5684
Lamtor1	-5263	-4379
Lamtor2	-3504	-5054
Lamtor3	-3682	-1602
Lamtor4	-4240	-669
Lamtor5	-1266	-1840
Lats1	5607	4503
Lats2	-1646	-797
Ldlr	4127	4914
Lef1	3513	3977
Leo1	-296	-4202
Lepr	-142	-6431
Lfng	106	3406
Lgr4	4003	4823
Lgr6	-6753	-7517
Limk1	4291	3251
Limk2	1771	3826
Lingo1	6109	5414
Lpar1	7395	6811
Lpar3	4601	5821
Lpar4	-516	-1668
Lpar6	-4877	-4077
Lpl	-6603	-7708
Lrat	-5855	-3045
Lrig1	-632	-2134
Lrp1	7439	6377
Lrp10	6104	3421
Lrp12	6686	4703
Lrp5	1046	-3075
Lrp6	1802	1342
Lrp8	7444	7007
Lrrk2	4634	5145
Lyn	-3403	-2326
Mad1l1	-12	-3325
Mad2l1	4002	2547
Madd	-5791	-4960
Maf1	-5058	-4066
Maged1	6689	4367
Maml1	3911	1878
Maml2	3771	5100
Maml3	3555	6126
Mamld1	6981	5332
Map2k1	6233	2697
Map2k2	-6007	-3227
Map2k5	-3774	-4264
Map3k11	-5474	-3792
Map3k7	5998	6335
Mapk1	-4365	-6214
Mapk11	704	-262
Mapk12	6483	6788
Mapk14	-6492	-6835
Mapk3	1686	-900
Mapk4	7355	6908
Mapk6	6087	4519
Mapk7	5895	4620
Mapk8	-2142	-2173
Mapkap1	-1720	-152
Mapkapk2	-6622	-6346
Mapkapk3	-6669	-7022
Mapkapk5	-1163	-2612
Mapre1	5505	2614
Mark3	1135	2501
Matk	2481	430
Mbd3	-2157	-1335
Mcf2l	-5953	-3531
Mdk	6581	5923
Mdm2	4383	4102
Mecom	-84	-3781
Med1	-2830	-5832
Mef2a	-4158	-6983
Mef2c	4484	1893
Memo1	-3995	-4006
Men1	-3828	-2806
Met	6093	6741
Metap1	-1174	-5708
Metap2	-2031	-4987
Mfng	-2705	-2880
Mgll	-4506	-7118
Mib1	6305	6233
Mib2	146	1867
Mis12	2149	1258
Mknk1	82	-2969
Mkrn1	-2162	151
Mks1	-197	-1194
Mlst8	-3469	-4665
Mmp2	7497	6885
Mmp3	-1265	4045
Mmp9	1226	-6359
Mob1a	4148	2195
Mob1b	3081	4724
Mov10	1010	4998
Mrtfa	5622	4869
Mst1r	5454	5761
Mta1	1936	-815
Mta2	1194	-2200
Mta3	-2683	-5653
Mtmr4	-4330	-6504
Mtor	-3404	-6096
Mxd4	-503	4061
Myc	6780	6070
Myd88	3554	1097
Myh10	7030	6918
Myh11	-4929	-1359
Myh14	-2234	1900
Myh9	4478	4696
Myl12b	844	518
Myl9	-1361	-776
Mylip	-2606	-5414
Mylk	-6527	-5002
Myo7a	372	5690
Myo9a	4272	5299
Myo9b	6123	6374
Napepld	7118	6773
Ncam1	7473	7015
Ncbp1	-1233	-1762
Ncbp2	-2016	-4430
Ncf1	2045	4058
Ncf2	-2110	-1024
Ncf4	1120	-162
Nck1	-5781	-2739
Nck2	751	-2199
Nckap1	2822	498
Nckap1l	3635	2738
Nckipsd	-4855	-4041
Ncoa1	-4484	-6419
Ncoa2	-3912	-6801
Ncoa3	-6727	-4373
Ncor1	-4730	-6152
Ncor2	4764	3742
Ncstn	2223	347
Ndc80	3091	4617
Nde1	-4494	-3709
Ndel1	-1965	2152
Nedd4	5576	-1974
Nedd4l	-4561	-6654
Nedd8	95	641
Nelfb	-2095	-618
Net1	-4491	2579
Neurl1a	5807	4354
Neurl1b	-1218	-680
Nf1	2150	651
Nf2	-2295	3059
Nfatc1	2378	2808
Nfkb1	5207	5410
Nfkbia	364	2648
Ngef	7494	6990
Ngf	6828	6946
Ngfr	5700	3964
Nlk	-5547	-7061
Nln	2623	-3323
Nmb	-4745	-5035
Nmt1	934	594
Nmt2	6738	6635
Nos3	-4231	-4860
Notch1	-6300	-5112
Notch2	4024	5213
Notch3	1350	-5471
Noxo1	1334	2139
Npff	-1834	1384
Nphp4	4269	3539
Npy1r	978	-2170
Npy4r	352	-3079
Nr1h2	-243	1102
Nr1h3	-1853	-4977
Nr3c1	2927	-1142
Nr4a1	598	-644
Nr5a2	-4208	-4606
Nras	4487	1253
Nrg1	6778	5305
Nrg2	-4533	-5895
Nrg4	200	-2672
Nrip1	5461	5212
Nrp1	144	-6138
Nrp2	-5657	-3337
Nrtn	866	3783
Nsl1	2327	1594
Nsmaf	-6465	-7476
Ntf3	-4384	-5029
Ntrk2	3915	-42
Ntrk3	3218	3871
Nts	4307	303
Ntsr2	3942	5450
Nudc	-4977	-1529
Nuf2	4155	3051
Numb	-2546	-1006
Nup107	-1252	-1977
Nup133	-2488	-1920
Nup160	2576	936
Nup37	-326	-4277
Nup43	-462	-1511
Nup85	-2481	-84
Nup98	3276	-3680
Obscn	-4921	3216
Ocrl	782	-3741
Ofd1	3240	632
Olfr1034	6398	6799
Olfr2	-3859	2069
Olfr558	-4662	-3828
Olfr635	1270	2056
Olfr78	-4390	-1527
Olfr958	-1697	-176
Ophn1	1693	4686
Opn3	6251	6482
Opn4	-5228	-5365
Os9	4038	2735
Otud3	684	1464
Otud7b	6943	4170
Otulin	7371	6868
Oxtr	3864	4319
P2ry1	-3691	-7665
P2ry12	-387	-1378
P2ry13	1125	-1923
P2ry14	-6013	-6951
P2ry2	1396	142
P2ry6	3732	3541
P4hb	6441	4378
Pafah1b1	-3476	-5904
Pag1	5835	2769
Pak1	3769	3862
Pak2	1636	-1595
Pak3	6228	5449
Paqr3	4109	-1190
Pard3	-3449	-5368
Pard6a	-2913	661
Parp1	-6470	-6763
Pbx1	4884	-5143
Pck1	1338	425
Pcsk5	5871	6552
Pcsk6	-485	281
Pde10a	5913	6948
Pde1a	5847	5867
Pde1b	1175	-1748
Pde1c	-6385	-6860
Pde3a	-556	-5096
Pde3b	1195	-361
Pde4a	-7051	-7640
Pde4b	5944	-1416
Pde4c	-6981	-7481
Pde4d	-6468	-7754
Pde7a	-6098	-7041
Pde7b	6603	6405
Pde8a	1890	6284
Pde8b	-6620	-7360
Pdgfa	-2171	-2809
Pdgfb	-3222	-3725
Pdgfc	6687	6380
Pdgfd	-5527	-7152
Pdgfra	7368	6328
Pdgfrb	3463	2097
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Pdk1	4156	-6364
Pdk2	-6889	-7055
Pdk3	6805	6440
Pdk4	-1655	1645
Pdpk1	3688	3414
Pea15a	4964	5890
Pelp1	-1310	-2256
Penk	-5937	-6873
Pfn1	3498	265
Pfn2	-2770	1092
Pgf	-4967	-6219
Phb	-7148	-7279
Phc1	5898	3435
Phc2	3502	2510
Phc3	-552	3145
Phlpp1	-5505	-6098
Phlpp2	2251	3575
Pik3ap1	3796	3098
Pik3c3	1891	-2240
Pik3ca	5242	5659
Pik3cb	3757	6013
Pik3cd	-120	1463
Pik3cg	4057	-374
Pik3r1	-7121	-7646
Pik3r2	7218	5112
Pik3r3	5367	1103
Pik3r4	480	-3782
Pik3r5	3057	3873
Pik3r6	-4434	-4988
Pin1	-5108	-3060
Pip4k2a	6260	5583
Pip4k2b	-575	-1112
Pip4k2c	207	-860
Pip5k1a	6376	5464
Pip5k1b	3999	-4337
Pip5k1c	3011	4725
Pkn1	2860	1620
Pkn2	-312	-2850
Pkn3	-1847	2767
Pla2g4a	7342	6860
Plat	6708	4965
Plb1	-2327	-2998
Plcb1	-977	766
Plcb2	-4621	-1825
Plcb3	-3277	-2733
Plcb4	-980	6820
Plcg1	-3635	-5144
Plcg2	7267	6597
Plekhg2	3374	4923
Plekhg5	-3293	-2062
Plin1	-369	-3417
Plk1	4893	4675
Plppr2	4295	-3751
Plppr3	2341	2927
Pltp	-6485	-6391
Plxnb1	-6551	-7610
Plxnd1	-5807	-6242
Pmepa1	7253	6803
Pmf1	-5130	-235
Pml	3342	3906
Pofut1	2769	2653
Poglut1	5254	5246
Polr2a	6257	6088
Polr2b	-2114	-5462
Polr2c	-6315	-5526
Polr2d	1353	1947
Polr2e	-5768	-4184
Polr2f	-5670	-3523
Polr2g	-710	1918
Polr2h	2179	2054
Polr2i	-4458	-3921
Polr2j	-6400	-7115
Polr2k	-3246	-2310
Polr2l	-4278	-1946
Porcn	4286	5324
Pou2f1	975	-3512
Ppard	-5588	-4490
Pparg	-4842	-2722
Ppbp	6229	-3145
Ppid	-4037	-4168
Ppm1a	2517	-2532
Ppp1ca	-2389	-1250
Ppp1cb	-6139	-5952
Ppp1cc	-3515	-5893
Ppp1r12a	5759	6479
Ppp1r12b	5090	3091
Ppp1r14a	1274	-2970
Ppp1r15a	7165	6933
Ppp2ca	1302	1549
Ppp2cb	2162	-1862
Ppp2r1a	-5112	-3845
Ppp2r1b	-1090	-2605
Ppp2r5a	-4333	-2908
Ppp2r5b	2746	2750
Ppp2r5c	1996	-3715
Ppp2r5d	-3601	-2560
Ppp2r5e	-1513	-2737
Ppp3ca	-1178	-2997
Ppp3cb	-5310	-6375
Ppp3cc	483	-771
Ppp3r1	1460	-6334
Ppp5c	-6196	-5229
Prc1	4550	5871
Prdm4	3251	-287
Prex1	2235	3565
Prex2	-1702	571
Prickle1	-6118	-6767
Prkaa1	3612	3708
Prkaa2	-6100	-7414
Prkab1	-4034	-7255
Prkab2	7420	5930
Prkaca	-6075	-5990
Prkacb	3875	-3919
Prkag1	-6213	-4030
Prkag2	4029	-2192
Prkag3	5303	4957
Prkar1a	6142	4210
Prkar1b	1256	1039
Prkar2a	-4064	-4969
Prkar2b	3433	313
Prkca	5539	5603
Prkcb	-2478	79
Prkcd	5903	6193
Prkce	-6616	-7488
Prkcg	-5018	984
Prkch	-922	-6325
Prkci	6335	5716
Prkcq	-3932	-3811
Prkcz	3641	-4318
Prkg1	6214	6308
Prkg2	108	528
Prkx	3534	1608
Prmt1	-3813	-342
Prr5	3078	3102
Psap	-7208	-7432
Psen1	-309	-25
Psen2	297	-3336
Psenen	1615	1894
Psma1	-5057	-5354
Psma3	-1668	-1270
Psma4	-4195	-5256
Psma5	917	4879
Psma6	-6198	-4392
Psma7	-5203	-1132
Psmb1	-3490	-1504
Psmb10	3247	6154
Psmb2	-6229	-6389
Psmb3	-6394	-4507
Psmb4	-4157	-2719
Psmb5	-5358	-2463
Psmb6	-5905	-4631
Psmb7	-6295	-6022
Psmb8	188	2895
Psmb9	239	987
Psmc1	-4509	-1482
Psmc2	-5438	-4371
Psmc3	-5727	-3198
Psmc4	580	1965
Psmc5	-5068	-3092
Psmc6	-3319	55
Psmd1	-4493	-2930
Psmd10	2830	-1174
Psmd11	5474	5901
Psmd12	-5949	-6045
Psmd13	2269	4514
Psmd14	1389	1667
Psmd2	-4258	-2549
Psmd3	-5414	-2387
Psmd4	-73	2814
Psmd5	2751	2805
Psmd6	-2219	-3583
Psmd7	-3344	2462
Psmd8	5830	6151
Psmd9	811	-3604
Psme1	-7082	-7176
Psme2b	-2823	-3837
Psme3	-4430	-5111
Psme4	-5860	-5252
Psmf1	1562	263
Ptafr	-2736	-5277
Ptbp1	4852	1439
Ptch1	-1939	-3608
Ptch2	6537	5843
Pten	679	-2222
Ptger1	1839	2898
Ptger3	5523	3162
Ptger4	6624	6526
Ptges3	-3953	-1978
Ptgfr	6271	6752
Ptgir	5726	6130
Pth1r	4651	1522
Pthlh	6	5918
Ptk2	1246	-212
Ptk2b	7351	6468
Ptk6	-2549	491
Ptpn1	4586	4701
Ptpn11	-3358	-3525
Ptpn12	5187	5770
Ptpn18	52	-3444
Ptpn2	1817	-1067
Ptpn3	-6494	-6447
Ptpn6	-2833	1877
Ptpra	5104	4674
Ptprj	2717	4545
Ptprk	6137	6417
Ptpro	1689	4448
Ptprs	6547	183
Ptpru	4563	-2844
Pxn	-1407	-2587
Pygo1	-4173	-7077
Pygo2	2199	3405
Rab4a	1717	2240
Rab4b	6975	6460
Rab6a	6083	2806
Rac1	328	-2928
Rac2	823	799
Rac3	-3904	-1682
Racgap1	4251	3966
Rack1	642	-1334
Rad21	-3255	-4850
Raf1	-6123	-5527
Rala	-696	-1429
Ralb	3304	2329
Ralbp1	-526	3178
Ralgds	6084	3194
Ramp1	-4778	2138
Ramp2	-3975	-4634
Ramp3	288	-3187
Ranbp10	-2269	-2315
Ranbp2	1943	-1227
Ranbp9	-1815	-6651
Rangap1	3393	3196
Rap1a	3944	-2069
Rap1b	6393	4567
Rapgef1	4261	4786
Rapgef2	-6256	-6730
Rapgef3	-5740	-4083
Rapgef4	3528	4499
Rara	6256	3952
Rarb	34	-1746
Rarg	-5951	125
Rasa1	5272	2320
Rasa2	5395	4299
Rasa3	6410	5215
Rasa4	3259	6419
Rasal2	-5837	-6112
Rasal3	-62	4336
Rasgef1a	6103	6165
Rasgrf2	-3199	-6106
Rasgrp1	4699	-1211
Rasgrp2	-6821	-6530
Rasgrp3	-6184	-7249
Rasgrp4	-14	-2506
Rbbp5	-4856	-6187
Rbbp7	-5747	-6737
Rbck1	-3674	709
Rbfox2	5114	3646
Rbl1	2210	535
Rbp1	7370	6838
Rbp4	6701	6970
Rbpj	5761	3338
Rbx1	-4743	-4554
Rcc2	6100	3622
Rcor1	3113	25
Rdh10	1223	-2164
Rdh11	6388	6267
Rdh13	-6238	-6789
Rdh14	-5721	-5631
Rdh5	2259	2260
Reep1	2294	-3695
Reep2	4946	4249
Reep3	5439	5042
Reep4	4120	1704
Reep5	-6562	-6934
Reep6	-187	-2258
Rela	4961	3728
Rest	3977	-1988
Ret	-6992	-7093
Retsat	-5701	-5739
Rfng	-2151	-3350
Rgs10	3314	1427
Rgs11	4854	5703
Rgs12	1604	-1186
Rgs14	-2822	238
Rgs16	613	2632
Rgs17	-1480	-909
Rgs18	-973	-1967
Rgs19	651	2967
Rgs2	-6576	-6332
Rgs3	3522	-739
Rgs4	-5640	-6533
Rgs5	-4183	-7291
Rgs6	-6443	-3786
Rgs7	-5993	4356
Rheb	-1490	-3743
Rhoa	-857	-3472
Rhob	-2721	843
Rhobtb1	-5088	4133
Rhobtb2	-5296	-5057
Rhoc	7516	7014
Rhod	6824	5768
Rhof	541	1024
Rhog	3241	1616
Rhoh	2055	1099
Rhoj	5105	-11
Rhoq	-3009	1655
Rhot1	-5531	-6842
Rhot2	-7264	-7380
Rhou	7185	6742
Rhpn2	-5643	-2198
Rictor	-32	2797
Ring1	3578	1778
Ripk1	3817	949
Ripk2	1005	3673
Rit1	-4246	-4163
Rnf111	268	-2449
Rnf146	-2003	400
Rnf2	6290	-1872
Rnf31	-6604	-2513
Rnf41	2004	1374
Rock1	1759	4127
Rock2	5744	5722
Ror1	5976	2939
Ror2	5904	5574
Rpgrip1l	-717	-2020
Rps27a	-1504	-1029
Rps6ka1	4173	287
Rps6ka2	5542	-5598
Rps6ka3	1822	3743
Rps6ka5	-5011	-6124
Rps6kb2	-1419	-1750
Rptor	-3707	-4140
Rraga	2409	-2434
Rragb	-280	-339
Rragc	620	-2989
Rragd	-6591	-7671
Rspo1	2701	-1369
Rtkn	6709	6078
Rtn4	7507	7050
Rtp3	-5445	-812
Rtp4	943	5444
Runx1	5868	6372
Runx3	2355	4039
Ruvbl1	1316	3391
Rxfp1	-3311	1308
Rxra	-6194	-6804
Rxrb	-3171	-3373
Rxrg	-7326	-7713
Ryk	2896	-2493
S100b	1435	3319
S1pr1	-4036	-4393
S1pr2	7139	6370
S1pr3	-5077	-7131
S1pr4	-4948	-3081
Sag	-370	1888
Sall4	-5535	-5738
Sav1	5451	4022
Scai	4928	6541
Scd4	-6898	-6839
Scmh1	-6058	-6434
Scrib	171	483
Scube2	7260	6768
Sdc1	7061	4784
Sdc2	7435	6631
Sdc3	4012	3827
Sdc4	4355	-9
Sec13	1575	39
Seh1l	326	-1812
Sel1l	3457	1172
Sept7	5527	145
Serpine1	7216	6353
Sfn	2885	2824
Sfpq	-4112	-2779
Sfrp1	6854	4984
Sfrp2	6895	6219
Sgo1	3622	4002
Sgo2a	-4752	-6848
Sh2b1	-4224	-4620
Sh2b2	3560	2688
Sh2b3	-1214	-3199
Sh2d2a	6450	5809
Sh3gl1	6183	5598
Sh3kbp1	-6312	-6825
Sharpin	-4324	-2788
Shb	-4470	-1448
Shc1	5764	3996
Shc3	2587	5257
Sirt6	3824	979
Ska2	-4845	-5522
Ski	5082	5289
Skil	7055	6612
Skp1a	-2255	-5461
Slc38a9	-3317	-2618
Smad1	5072	4831
Smad2	2945	-931
Smad3	3925	-4081
Smad4	4924	4471
Smad5	-888	301
Smad6	4152	4350
Smad7	6193	5962
Smarca4	-2464	-2104
Smc1a	3576	445
Smc3	1642	-3069
Smo	6594	5579
Smpd2	-5709	-5563
Smpd3	4558	4699
Smurf1	6281	2428
Smurf2	5768	4293
Snai1	7036	5217
Snai2	1651	1231
Snw1	-1591	-2219
Snx3	-3539	-3143
Socs1	1854	3043
Socs3	2520	-1464
Socs6	2568	3445
Sos1	2066	-1197
Sos2	-3207	-5369
Sost	6907	3476
Sox13	-1353	-1652
Sox17	128	-1208
Sox4	5142	494
Sox6	-2975	-4786
Sox7	-6142	-6016
Sox9	6960	5978
Sp1	2620	521
Sparc	6776	6134
Spc24	1404	-6146
Spc25	3620	4682
Sphk1	6933	6215
Spint2	1959	-3378
Spop	-6978	-5773
Spopl	4727	3415
Spp1	4125	6580
Sppl2a	-3544	316
Sppl2b	-1404	-2692
Spred1	6396	5800
Spred2	-4172	-4121
Spred3	4910	4950
Spry1	7022	5250
Spry2	5953	5848
Spta1	-2545	-5699
Sptan1	-525	5294
Sptb	-1715	1502
Sptbn1	-4084	-4692
Sptbn2	-1231	1110
Sptbn5	3367	6778
Sqstm1	6438	5880
Src	7196	6795
Srebf1	5979	2962
Srf	-5021	-14
Srgap1	2690	4727
Srgap2	-5256	4186
Srgap3	7276	7005
Sstr3	-332	85
Sstr4	-5350	-1133
St3gal3	-6777	-6624
St3gal4	4466	-4957
St3gal6	-4673	-4593
Stag1	-170	1246
Stag2	5515	3921
Stam	1544	-52
Stam2	5387	2587
Stap2	-4055	-3470
Stard13	595	-1013
Stard8	-6730	-5564
Stat1	-1595	3287
Stat3	4087	345
Stat5a	-5331	-4559
Stat5b	-6561	-6176
Stat6	344	3106
Stk11	-6289	-2130
Stk3	3645	3649
Stk4	7525	7053
Stmn1	-539	-2259
Strada	5651	5696
Stradb	-2878	-5485
Strap	-4820	-5355
Strn	6430	5306
Stub1	-5590	-3107
Sufu	2792	1886
Suz12	-226	-4267
Syde1	3483	3605
Syde2	-6069	-6969
Syk	7447	6814
Syngap1	6613	5051
Syvn1	250	-3418
Tab1	213	-3626
Tab2	918	-5121
Tab3	-2148	-5192
Tacc3	6168	3333
Tagap1	-2903	-3788
Taok1	-628	-2298
Tas1r3	769	931
Tax1bp1	5166	3004
Tax1bp3	6927	6166
Tbl1x	3008	-5102
Tbl1xr1	4225	-2715
Tbp	-1125	-174
Tbxa2r	-859	-991
Tcf4	3779	5704
Tcf7	329	458
Tcf7l1	2936	-1832
Tcf7l2	1954	-4942
Tcirg1	5449	6363
Tec	5404	5137
Tek	-3811	-6622
Tfdp1	4017	1507
Tfdp2	-4634	-7148
Tgfa	6309	4116
Tgfb1	6984	5531
Tgfbr1	7285	6857
Tgfbr2	6843	5799
Tgif1	6842	6437
Tgif2	4702	866
Thbs1	6742	6178
Thbs2	4196	3190
Thbs3	7229	6555
Thbs4	7358	7046
Them4	-5770	-5601
Tia1	-3531	-3238
Tial1	-1287	-2944
Tiam1	-31	-4453
Tiam2	6979	6942
Tjp1	-3710	-5609
Tjp2	6209	6194
Tle1	2174	1542
Tle2	-3683	-3678
Tle3	-597	2928
Tle4	-760	-1850
Tle5	-7156	-6326
Tln1	6888	5990
Tlr9	-2209	-2526
Tmed2	4476	-272
Tmed5	-1898	-5571
Tnfaip3	5930	5656
Tnfrsf1a	5169	3989
Tnfrsf26	1739	3486
Tnfsf10	-4361	-3659
Tnks	3088	977
Tnks2	-4497	-6705
Tnrc6a	2787	3757
Tnrc6b	-2152	-5612
Tnrc6c	-4242	-3100
Tns3	7241	6891
Tradd	5674	5445
Traf1	4681	4599
Traf2	-9	1142
Traf6	513	-1168
Trib3	-3278	1445
Trim27	3068	1379
Trim33	3450	122
Trio	3882	4600
Trip10	-6149	-6123
Trp53	4978	4881
Trpc3	-6242	-6395
Trrap	1560	1002
Tsc1	-4853	-4582
Tsc2	-3865	-6161
Ttc21b	4112	-2729
Ttr	-2307	6470
Tulp3	6304	5041
Tyk2	3861	4516
Ubb	5763	-1908
Ubc	-1436	-1699
Ube2d1	-4576	-5721
Ube2d3	5709	3978
Ube2m	-4813	-4591
Uchl5	843	1974
Ucn	3274	1169
Uhmk1	-2299	-3509
Usf1	-1263	-2767
Usf2	-4810	-4587
Usp13	1158	556
Usp15	-3781	-6687
Usp2	-6852	-5821
Usp21	-2867	-2653
Usp34	2213	1140
Usp4	-1225	3358
Usp7	931	-1139
Usp8	-495	-2761
Usp9x	4374	-3676
Vangl2	649	-2820
Vapa	441	-3564
Vav1	1313	2886
Vav2	-1854	-1565
Vav3	3889	3173
Vcl	879	1982
Vcp	-2921	-3485
Vegfa	-6273	-7378
Vegfb	-7286	-6529
Vegfc	3481	4944
Vegfd	4357	5268
Vipr1	2212	-6136
Vipr2	-1069	3776
Vps26a	-4328	-5779
Vps29	4690	1077
Vps35	-1453	-3641
Vrk3	-2210	-2600
Vwf	6524	723
Was	1138	132
Wasf1	4733	5599
Wasf2	409	1969
Wasf3	3649	4473
Wasl	2624	5412
Wdr19	6141	5924
Wdr35	3095	2183
Wdr83	-6103	-5265
Wif1	-1685	387
Wipf1	6125	5621
Wipf2	-1848	464
Wipf3	3520	1967
Wls	7043	5989
Wnt11	1923	1975
Wnt16	5423	5960
Wnt2	-2905	2889
Wnt2b	-1284	1055
Wnt4	-535	3355
Wnt5a	-2222	-4294
Wnt5b	6697	4902
Wnt9a	6560	5891
Wnt9b	1592	1261
Wwc1	2276	-247
Wwox	1273	1831
Wwp1	-4660	-6870
Wwp2	5224	4793
Wwtr1	4739	5130
Xcr1	4390	72
Xiap	-716	-3113
Xk	2586	1696
Xpo1	-1345	814
Yap1	5991	4386
Ybx1	-6721	-5905
Yes1	3401	4968
Ywhab	1382	-1493
Ywhae	-5312	-6195
Ywhag	-2287	-1315
Ywhah	5584	3890
Ywhaq	2145	2532
Ywhaz	5524	2659
Yy1	-1198	-3412
Zdhhc21	4006	5338
Zdhhc7	-5621	-4543
Zfp217	-904	-3394
Zfyve9	-4979	-5880
Znrf3	-2034	-2747
Zranb1	2057	2432
Zw10	4767	6235
Zwilch	3654	4241
Zwint	4604	5466

---

---

ECM-proteoglycans

ECM-proteoglycans

metric	value
setSize	43
pMANOVA	3.42e-13
p.adjustMANOVA	1.9e-11
s.dist	0.886
s.young	0.661
s.old	0.59
p.young	6.2e-14
p.old	2.23e-11

Top 20 genes

Gene	young	old
Ncam1	7473	7015
Tgfb2	7427	6986
Bgn	7481	6830
Tgfb3	7433	6863
Aspn	7430	6781
Dcn	7414	6701
Lama2	7478	6628
Itgav	7314	6700
Vcan	7188	6694
Col9a2	7498	6397
Serpine1	7216	6353
Lum	7163	6376
Lamc1	7347	5936
Itgb5	7035	6117
Fmod	6247	6867
Itgb3	7496	5721
Sparc	6776	6134
Itga9	6082	6594
Itgb1	6770	5825
Tgfb1	6984	5531

Click HERE to show all gene set members

All member genes

	young	old
Agrn	-247	199
Aspn	7430	6781
Bgn	7481	6830
Col9a2	7498	6397
Comp	4501	6797
Dag1	3395	1176
Dcn	7414	6701
Fmod	6247	6867
Hapln1	-1235	1714
Hspg2	6535	3769
Itga2	3765	6228
Itga2b	5803	437
Itga7	6140	5835
Itga8	3673	5405
Itga9	6082	6594
Itgav	7314	6700
Itgax	1846	526
Itgb1	6770	5825
Itgb3	7496	5721
Itgb5	7035	6117
Itgb6	-4680	-6503
Lama2	7478	6628
Lama3	1858	-436
Lama4	3147	2662
Lama5	5048	-4782
Lamb1	6771	-983
Lamb2	2375	4485
Lamc1	7347	5936
Lrp4	2160	909
Lum	7163	6376
Matn4	4806	5530
Ncam1	7473	7015
Ptprs	6547	183
Serpine1	7216	6353
Sparc	6776	6134
Tgfb1	6984	5531
Tgfb2	7427	6986
Tgfb3	7433	6863
Tnc	4757	6330
Tnr	4918	5633
Tnxb	6557	4769
Vcan	7188	6694
Vtn	-7117	-7433

---

---

Glycosaminoglycan-metabolism

Glycosaminoglycan-metabolism

metric	value
setSize	99
pMANOVA	1.18e-12
p.adjustMANOVA	6.29e-11
s.dist	0.551
s.young	0.431
s.old	0.343
p.young	1.26e-13
p.old	3.57e-09

Top 20 genes

Gene	young	old
Cd44	7295	7013
Bgn	7481	6830
Cspg4	7500	6779
Dcn	7414	6701
Sdc2	7435	6631
Dse	7298	6706
Dsel	7222	6720
Vcan	7188	6694
Hexa	7315	6493
Hs2st1	7325	6476
Lum	7163	6376
Ext1	6621	6756
Chpf2	6949	6362
Gpc6	6891	6273
Fmod	6247	6867
Chpf	7328	5652
Omd	6306	6521
St3gal2	6995	5852
Prelp	6330	6402
Chsy1	7110	5672

Click HERE to show all gene set members

All member genes

	young	old
Abcc5	-766	3315
Agrn	-247	199
Arsb	6684	5613
B3galt6	4154	3582
B3gat2	2242	2141
B3gat3	-677	-1460
B3gnt2	6711	5903
B3gnt3	-5788	-6546
B4galt1	3267	1068
B4galt2	6315	4664
B4galt3	-4310	-1405
B4galt4	-4249	-652
B4galt5	6407	5561
B4galt6	6036	6103
B4galt7	-1177	-3787
Bgn	7481	6830
Cd44	7295	7013
Cemip	3758	3579
Chp1	-1311	-5595
Chpf	7328	5652
Chpf2	6949	6362
Chst1	1851	-809
Chst11	1137	4315
Chst12	4324	4171
Chst14	5647	3716
Chst15	-359	-4584
Chst2	1230	685
Chst3	6451	6127
Chst7	1335	-705
Chsy1	7110	5672
Chsy3	6387	6260
Csgalnact1	2042	-2352
Csgalnact2	6411	5972
Cspg4	7500	6779
Cspg5	-3048	1942
Dcn	7414	6701
Dse	7298	6706
Dsel	7222	6720
Ext1	6621	6756
Ext2	1986	-1619
Fmod	6247	6867
Glb1	5822	1047
Glb1l	5086	5055
Glce	179	-4014
Gm50388	-923	1381
Gns	-4478	-5630
Gpc1	-3801	-4293
Gpc3	2127	-5769
Gpc4	-3619	-6582
Gpc6	6891	6273
Gusb	6165	4930
Has2	3121	-228
Has3	-4602	2169
Hexa	7315	6493
Hexb	5022	5616
Hmmr	4663	2855
Hpse	4346	-2233
Hs2st1	7325	6476
Hs3st1	-493	-13
Hs3st3a1	6472	4761
Hs3st3b1	1722	-4410
Hs6st1	6013	5322
Hs6st2	2526	-4992
Hspg2	6535	3769
Hyal1	4392	6096
Hyal2	2666	4079
Ids	6784	4640
Idua	-5121	-5157
Lum	7163	6376
Lyve1	-4896	-3254
Naglu	4598	2203
Ndst1	-1729	-4940
Ndst2	4415	2740
Ndst3	3651	3254
Ogn	6618	4809
Omd	6306	6521
Papss1	6380	4162
Papss2	-4199	-3702
Prelp	6330	6402
Sdc1	7061	4784
Sdc2	7435	6631
Sdc3	4012	3827
Sdc4	4355	-9
Sgsh	6079	5115
Slc26a2	-759	-1286
Slc35b2	4862	161
Slc35b3	5663	5610
Slc35d2	6737	5737
Slc9a1	4694	3003
St3gal1	3058	716
St3gal2	6995	5852
St3gal3	-6777	-6624
St3gal4	4466	-4957
St3gal6	-4673	-4593
Stab2	229	2485
Ust	6358	6176
Vcan	7188	6694
Xylt1	6328	6030
Xylt2	2935	-1769

---

---

Peroxisomal-protein-import

Peroxisomal-protein-import

metric	value
setSize	53
pMANOVA	2.97e-12
p.adjustMANOVA	1.52e-10
s.dist	0.729
s.young	-0.446
s.old	-0.577
p.young	1.95e-08
p.old	3.55e-13

Top 20 genes

Gene	young	old
Dhrs4	-7344	-7770
Acot2	-7253	-7797
Phyh	-7261	-7709
Gstk1	-7200	-7732
Crat	-7321	-7591
Ech1	-7282	-7627
Gnpat	-7105	-7547
Ephx2	-6954	-7595
Scp2	-6736	-7268
Mlycd	-6864	-7040
Amacr	-6767	-7086
Hsd17b4	-6387	-7282
Nudt7	-6026	-7008
Nudt19	-6768	-6057
Ehhadh	-5758	-7027
Pex7	-6116	-6538
Pex10	-6076	-6073
Lonp2	-5285	-6862
Pecr	-5886	-6147
Pex6	-6267	-5589

Click HERE to show all gene set members

All member genes

	young	old
Acot2	-7253	-7797
Acot4	825	-4529
Acot8	559	-172
Acox1	-4724	-7321
Acox3	1630	-3864
Agps	-605	-2899
Amacr	-6767	-7086
Cat	-2626	-1549
Crat	-7321	-7591
Crot	-1116	-3382
Ddo	-5929	-5213
Decr2	-2640	-3902
Dhrs4	-7344	-7770
Ech1	-7282	-7627
Ehhadh	-5758	-7027
Ephx2	-6954	-7595
Gm11808	-5706	-216
Gnpat	-7105	-7547
Gstk1	-7200	-7732
Hmgcl	-6101	-4870
Hsd17b4	-6387	-7282
Ide	-4424	-4327
Idh1	-3318	-6643
Lonp2	-5285	-6862
Mlycd	-6864	-7040
Mpv17	-5642	-5830
Nos2	-5173	-6317
Nudt19	-6768	-6057
Nudt7	-6026	-7008
Paox	3632	-605
Pecr	-5886	-6147
Pex1	-1700	-4722
Pex10	-6076	-6073
Pex12	2346	-4157
Pex13	-771	-5620
Pex14	809	-2777
Pex2	-5398	-6265
Pex26	-2597	-2650
Pex5	5993	2191
Pex6	-6267	-5589
Pex7	-6116	-6538
Phyh	-7261	-7709
Pipox	3254	2820
Rps27a	-1504	-1029
Scp2	-6736	-7268
Tysnd1	-504	-3360
Ubb	5763	-1908
Ubc	-1436	-1699
Ube2d1	-4576	-5721
Ube2d2a	-681	-3716
Ube2d3	5709	3978
Usp9x	4374	-3676
Zfand6	-5659	-5819

---

---

Metabolism-of-amino-acids-and-derivatives

Metabolism-of-amino-acids-and-derivatives

metric	value
setSize	256
pMANOVA	1.02e-11
p.adjustMANOVA	5.03e-10
s.dist	0.347
s.young	-0.241
s.old	-0.251
p.young	3.75e-11
p.old	5.47e-12

Top 20 genes

Gene	young	old
Bckdha	-7342	-7803
Rpl3l	-7308	-7793
Hibadh	-7283	-7717
Acat1	-7263	-7711
Dld	-7216	-7696
Mccc2	-7174	-7704
Ckm	-7215	-7641
Dlst	-7165	-7693
Pdhx	-7172	-7679
Ivd	-7138	-7712
Gcdh	-7112	-7726
Ndufab1	-7247	-7579
Aldh6a1	-6998	-7778
Adi1	-7100	-7626
Ckmt2	-7223	-7479
Got1	-7159	-7522
Gpt2	-7080	-7535
Pxmp2	-6949	-7658
Aldh4a1	-7153	-7436
Kyat1	-7245	-7312

Click HERE to show all gene set members

All member genes

	young	old
Aass	2387	-691
Acad8	-6496	-7039
Acadsb	-5889	-7297
Acat1	-7263	-7711
Adi1	-7100	-7626
Ado	23	-3026
Afmid	-2177	-5588
Aimp1	-2872	-3408
Aimp2	-1669	2875
Aldh18a1	6276	3540
Aldh4a1	-7153	-7436
Aldh6a1	-6998	-7778
Aldh7a1	340	-5395
Aldh9a1	-3846	-6971
Amd2	-4381	-1651
Amt	-5168	1070
Apip	-6666	-7349
Asl	7069	6794
Asns	4991	912
Aspa	530	1151
Asrgl1	-5841	-3768
Ass1	4425	5786
Auh	-6904	-7596
Azin1	7005	6713
Azin2	5514	5956
Bcat1	4700	5242
Bcat2	-6905	-7609
Bckdha	-7342	-7803
Bckdhb	-6907	-7611
Bckdk	-6679	-6373
Bhmt	-2632	2010
Carnmt1	-7017	-6894
Carns1	-4558	-4571
Cbs	-35	2170
Cdo1	-2028	-1915
Ckb	7244	4926
Ckm	-7215	-7641
Ckmt2	-7223	-7479
Cps1	-3405	1717
Csad	6740	-92
Dbh	-7033	-5268
Dbt	-6615	-7756
Dct	-827	-752
Ddc	4170	2144
Ddo	-5929	-5213
Dhtkd1	-4047	-5919
Dio2	7388	6999
Dlat	-7003	-7332
Dld	-7216	-7696
Dlst	-7165	-7693
Duox1	-6105	-6117
Duox2	-637	2294
Eef1e1	-4012	130
Eefsec	1269	951
Enoph1	1804	-600
Ethe1	-6340	-6782
Fah	-3841	-7452
Fau	519	-1304
Gamt	2034	-2938
Gatm	5165	1213
Gcat	-3565	-6828
Gcdh	-7112	-7726
Gcsh	-4256	-7388
Gldc	-2462	1585
Gls	761	3611
Gls2	1448	2505
Glud1	-6306	-7705
Glul	5185	-3734
Gm11808	-5706	-216
Gnmt	-3686	-5324
Got1	-7159	-7522
Got2	-6849	-6590
Gpt	-6704	-7562
Gpt2	-7080	-7535
Grhpr	1747	-5672
Gsr	-2257	-2617
Gstz1	-6066	-6846
Hdc	4610	3663
Hibadh	-7283	-7717
Hibch	-6982	-7198
Hnmt	-6197	-7393
Hoga1	-1971	695
Hsd17b10	-6937	-7410
Hykk	1262	-3138
Il4i1	414	921
Inmt	4201	-1469
Ivd	-7138	-7712
Kars	-1031	-313
Kmo	2534	411
Kyat1	-7245	-7312
Kyat3	-5753	-7786
Lias	-6337	-6370
Lipt1	-2499	-5036
Lipt2	-3800	-5935
Mat1a	-3249	748
Mccc1	-6826	-7722
Mccc2	-7174	-7704
Mpst	-5914	-5311
Mri1	-4671	-3221
Mtap	-672	-5228
Mtr	-6792	-7533
Mtrr	47	-4999
Naalad2	7383	6674
Nat8l	2705	-4548
Ndufab1	-7247	-7579
Nmral1	-5383	-4338
Nnmt	5824	4237
Nqo1	-3232	-6640
Oat	-6828	-7525
Oaz1	-6430	-4907
Oaz2	-6186	-4745
Odc1	5704	3746
Ogdh	-7013	-7475
Paox	3632	-605
Papss1	6380	4162
Papss2	-4199	-3702
Pcbd1	2289	1160
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Phgdh	4921	2827
Phykpl	-2929	-717
Pipox	3254	2820
Ppm1k	-6684	-7715
Prodh	-7310	-7241
Psat1	7217	5483
Psma1	-5057	-5354
Psma3	-1668	-1270
Psma4	-4195	-5256
Psma5	917	4879
Psma6	-6198	-4392
Psma7	-5203	-1132
Psmb1	-3490	-1504
Psmb10	3247	6154
Psmb2	-6229	-6389
Psmb3	-6394	-4507
Psmb4	-4157	-2719
Psmb5	-5358	-2463
Psmb6	-5905	-4631
Psmb7	-6295	-6022
Psmb8	188	2895
Psmb9	239	987
Psmc1	-4509	-1482
Psmc2	-5438	-4371
Psmc3	-5727	-3198
Psmc4	580	1965
Psmc5	-5068	-3092
Psmc6	-3319	55
Psmd1	-4493	-2930
Psmd10	2830	-1174
Psmd11	5474	5901
Psmd12	-5949	-6045
Psmd13	2269	4514
Psmd14	1389	1667
Psmd2	-4258	-2549
Psmd3	-5414	-2387
Psmd4	-73	2814
Psmd5	2751	2805
Psmd6	-2219	-3583
Psmd7	-3344	2462
Psmd8	5830	6151
Psmd9	811	-3604
Psme1	-7082	-7176
Psme2b	-2823	-3837
Psme3	-4430	-5111
Psme4	-5860	-5252
Psmf1	1562	263
Psph	-790	-3930
Pstk	-5599	-2337
Pxmp2	-6949	-7658
Pycr1	6421	4528
Pycr2	3676	3750
Qdpr	-5622	-6805
Rida	-1294	-3911
Rpl10-ps3	3212	1228
Rpl10a	2365	826
Rpl11	-1842	-1611
Rpl12	4829	5011
Rpl13	-1673	-925
Rpl13a	3206	1423
Rpl14	-1056	-1817
Rpl18	-544	-2116
Rpl18a	-1661	-1683
Rpl19	1021	-223
Rpl22l1	-697	990
Rpl23	893	-998
Rpl26	-440	315
Rpl27	-3812	-3262
Rpl28	-3522	-3053
Rpl29	-3071	-3308
Rpl3	6113	6294
Rpl30	-2113	-2803
Rpl32	210	-2635
Rpl34	639	-1667
Rpl35	-731	-1020
Rpl36	-4693	-3549
Rpl37a	1027	-952
Rpl38	2973	-609
Rpl3l	-7308	-7793
Rpl4	2299	-567
Rpl5	767	2478
Rpl6	-669	-2330
Rpl7a	-2054	-3718
Rpl8	-4247	-3018
Rplp1	1737	1206
Rps11	315	-2551
Rps12	2728	884
Rps13	-5050	-5764
Rps14	-1071	-1798
Rps15	-1045	-2489
Rps15a	-3231	-2769
Rps16	900	-494
Rps17	-4875	-5562
Rps19	-44	-2802
Rps20	2098	1064
Rps21	1421	-1394
Rps24	69	-130
Rps25	-2930	-2703
Rps27a	-1504	-1029
Rps27l	282	1037
Rps28	3137	-561
Rps3a1	-1317	-1655
Rps4x	810	-303
Rps5	1452	1852
Rps7	-2886	-1733
Rps8	1432	-1256
Rps9	-212	-1205
Rpsa	-3636	-3074
Sardh	2539	5655
Sat1	4779	5077
Scly	-3134	-2787
Sdsl	3468	3601
Secisbp2	-4438	-5781
Sephs2	-5227	-5985
Sepsecs	-179	-3327
Serinc1	4073	1017
Serinc2	6753	4559
Serinc3	-3501	-5421
Serinc5	-2159	-5552
Shmt1	-5511	-6829
Slc25a12	-7001	-7181
Slc25a13	-5896	-6938
Slc25a15	-1980	-6396
Slc36a4	5528	-2185
Slc3a2	4768	3376
Slc44a1	5879	3779
Slc6a8	7009	3623
Slc7a5	7017	6153
Smox	5632	4897
Sms	6724	2499
Srm	4398	4199
Srr	5378	4509
Suox	-4099	-5999
Tst	-6293	-7045
Txn2	-6882	-6420
Txnrd1	-793	-2917

---

---

rRNA-processing-in-the-mitochondrion

rRNA-processing-in-the-mitochondrion

metric	value
setSize	22
pMANOVA	1.56e-11
p.adjustMANOVA	7.41e-10
s.dist	1.16
s.young	-0.783
s.old	-0.854
p.young	2e-10
p.old	3.93e-12

Top 20 genes

Gene	young	old
mt-Co1	-7257	-7632
mt-Nd2	-7271	-7495
mt-Nd1	-7119	-7489
mt-Cytb	-6947	-7620
Hsd17b10	-6937	-7410
mt-Atp6	-7229	-7101
mt-Co3	-7307	-7023
Mrm2	-6671	-7643
mt-Nd4	-6682	-7382
mt-Nd5	-6386	-7564
mt-Co2	-7163	-6523
Nsun4	-6285	-7386
Mrm3	-6893	-6717
mt-Nd3	-6642	-5922
Mterf4	-5779	-6241
Trmt10c	-5141	-6714
mt-Nd4l	-3936	-7494
mt-Atp8	-3257	-6724
Tfb1m	-3569	-5783
Mrm1	-4507	-4469

Click HERE to show all gene set members

All member genes

	young	old
Elac2	-4160	-4011
Hsd17b10	-6937	-7410
Mrm1	-4507	-4469
Mrm2	-6671	-7643
Mrm3	-6893	-6717
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
mt-Co1	-7257	-7632
mt-Co2	-7163	-6523
mt-Co3	-7307	-7023
mt-Cytb	-6947	-7620
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd4l	-3936	-7494
mt-Nd5	-6386	-7564
Mterf4	-5779	-6241
Nsun4	-6285	-7386
Prorp	1087	-5691
Tfb1m	-3569	-5783
Trmt10c	-5141	-6714

---

---

Fatty-acid-metabolism

Fatty-acid-metabolism

metric	value
setSize	131
pMANOVA	2.54e-11
p.adjustMANOVA	1.16e-09
s.dist	0.46
s.young	-0.294
s.old	-0.353
p.young	6.46e-09
p.old	2.95e-12

Top 20 genes

Gene	young	old
Hadh	-7309	-7774
Acsl6	-7255	-7818
Acaa2	-7293	-7768
Eci1	-7341	-7716
Hadhb	-7300	-7759
Acot2	-7253	-7797
Decr1	-7267	-7777
Ptgr2	-7249	-7772
Echs1	-7313	-7662
Phyh	-7261	-7709
Hadha	-7254	-7673
Crat	-7321	-7591
Ndufab1	-7247	-7579
Acad11	-7134	-7691
Acadvl	-7306	-7500
Acadm	-7198	-7598
Mmut	-7065	-7739
Pcca	-7022	-7738
Mcee	-7015	-7616
Cpt2	-7007	-7546

Click HERE to show all gene set members

All member genes

	young	old
Abcc1	6729	6819
Abcd1	-6190	-6228
Acaa2	-7293	-7768
Acaca	3453	-653
Acad11	-7134	-7691
Acad12	-6749	-6851
Acadl	-6920	-7478
Acadm	-7198	-7598
Acads	-7280	-7250
Acadvl	-7306	-7500
Acbd4	3015	4544
Acbd5	6712	4401
Acbd6	-5225	-2979
Acly	-3791	-3425
Acot11	-6459	-7215
Acot13	-7060	-7028
Acot2	-7253	-7797
Acot4	825	-4529
Acot6	3177	-2145
Acot7	-5971	-6960
Acot8	559	-172
Acot9	7045	6582
Acox1	-4724	-7321
Acox3	1630	-3864
Acsf2	-5910	-7231
Acsf3	-6626	-7575
Acsl1	-6926	-7461
Acsl3	2818	-794
Acsl4	4513	954
Acsl5	3226	5103
Acsl6	-7255	-7818
Aldh3a2	-30	-948
Alox12	-652	-4906
Alox5	-6090	-7663
Alox5ap	925	-623
Alox8	-2406	3609
Amacr	-6767	-7086
Cbr1	-5186	-6178
Cbr4	-6830	-7226
Cpt1a	3375	-3304
Cpt1b	-6751	-7032
Cpt2	-7007	-7546
Crat	-7321	-7591
Crot	-1116	-3382
Cyp1b1	7393	6028
Cyp2u1	-6251	-6620
Cyp4b1	-6994	-6671
Cyp4f17	2111	2302
Dbi	-6324	-6808
Decr1	-7267	-7777
Decr2	-2640	-3902
Dpep1	6542	-2015
Dpep2	2183	4844
Echs1	-7313	-7662
Eci1	-7341	-7716
Ehhadh	-5758	-7027
Elovl1	5112	5663
Elovl5	-3997	-5603
Elovl6	3634	2877
Elovl7	4758	-245
Ephx2	-6954	-7595
Faah	5123	5120
Fads1	6269	5837
Fads2	6205	6018
Fasn	4789	4808
Ggt5	-2340	-6497
Gpx1	6364	6250
Gpx4	-5191	-4638
H2-Ke6	-6180	-5754
Hacd1	-4729	1304
Hacd2	4010	-3297
Hacd3	3435	5413
Hacd4	5683	4021
Hadh	-7309	-7774
Hadha	-7254	-7673
Hadhb	-7300	-7759
Hpgd	4297	-3880
Hpgds	5206	2923
Hsd17b12	1383	3088
Hsd17b4	-6387	-7282
Lta4h	5705	4468
Ltc4s	-2697	-1269
Mapkapk2	-6622	-6346
Mcat	-6474	-6636
Mcee	-7015	-7616
Mecr	-6170	-6438
Mid1ip1	-5373	-4247
Mlycd	-6864	-7040
Mmaa	-6691	-6758
Mmut	-7065	-7739
Morc2b	1565	2940
Ndufab1	-7247	-7579
Nudt19	-6768	-6057
Nudt7	-6026	-7008
Pcca	-7022	-7738
Pccb	-7054	-7359
Pctp	-3512	-6069
Pecr	-5886	-6147
Phyh	-7261	-7709
Pla2g4a	7342	6860
Pon2	7070	6950
Pon3	1714	1862
Ppard	-5588	-4490
Ppt1	800	-4376
Ppt2	-5289	-5808
Prkaa2	-6100	-7414
Prkab2	7420	5930
Prkag2	4029	-2192
Prxl2b	2509	-3979
Ptgds	6881	-7629
Ptges	-2486	1029
Ptges2	-7009	-6869
Ptges3	-3953	-1978
Ptgis	7197	6190
Ptgr1	3065	664
Ptgr2	-7249	-7772
Ptgs1	2392	1813
Ptgs2	5209	6187
Rxra	-6194	-6804
Scd4	-6898	-6839
Scp2	-6736	-7268
Slc22a5	-6362	-7316
Slc25a1	6669	5317
Slc25a17	-336	-4956
Slc25a20	-6911	-7554
Slc27a3	4118	4704
Tbxas1	-921	2117
Tecr	-7151	-6741
Tecrl	-1100	5110
Them4	-5770	-5601
Thrsp	-5942	-5944

---

---

Degradation-of-the-extracellular-matrix

Degradation-of-the-extracellular-matrix

metric	value
setSize	74
pMANOVA	5.69e-11
p.adjustMANOVA	2.49e-09
s.dist	0.531
s.young	0.445
s.old	0.289
p.young	3.56e-11
p.old	1.8e-05

Top 20 genes

Gene	young	old
Mmp2	7497	6885
Lamc2	7360	6977
Cd44	7295	7013
Col12a1	7235	7031
Col16a1	7349	6856
Ctsk	7416	6759
Dcn	7414	6701
Col14a1	7303	6796
Timp1	7129	6798
Col9a2	7498	6397
Cast	7085	6448
Bmp1	7236	6255
Col15a1	6814	6634
Lamc1	7347	5936
Spock3	6480	6467
Timp2	7029	5931
Mmp14	7280	5623
Capn2	6302	6179
Adamts8	6496	5738
Col26a1	7193	5097

Click HERE to show all gene set members

All member genes

	young	old
A2m	6437	1719
Adam10	5268	3108
Adam15	-324	-382
Adam17	289	-1999
Adam8	2453	-448
Adam9	7103	4428
Adamts1	4892	1782
Adamts4	4717	-509
Adamts5	3233	-4965
Adamts8	6496	5738
Adamts9	-4316	-4299
Bmp1	7236	6255
Bsg	-6548	-7267
Capn1	5990	-1442
Capn10	2312	2828
Capn12	-4526	-585
Capn15	-4124	-1273
Capn2	6302	6179
Capn3	-753	-6755
Capn5	4499	6035
Capn6	6326	5177
Capn7	-2762	-5831
Capns1	5582	1432
Casp3	6837	4230
Cast	7085	6448
Cd44	7295	7013
Cma1	988	82
Col12a1	7235	7031
Col13a1	2636	3872
Col14a1	7303	6796
Col15a1	6814	6634
Col16a1	7349	6856
Col18a1	6116	5391
Col23a1	5725	2177
Col25a1	-1076	474
Col26a1	7193	5097
Col9a2	7498	6397
Ctsb	-39	-2241
Ctsk	7416	6759
Ctss	3818	-193
Dcn	7414	6701
Furin	1738	-2954
Hspg2	6535	3769
Htra1	-756	-5946
Lama3	1858	-436
Lama5	5048	-4782
Lamb1	6771	-983
Lamb3	-6638	-7066
Lamc1	7347	5936
Lamc2	7360	6977
Mmp11	4144	625
Mmp12	-333	2038
Mmp13	-101	-5501
Mmp14	7280	5623
Mmp15	-6801	-6688
Mmp16	3955	3586
Mmp17	1629	413
Mmp19	6383	3258
Mmp2	7497	6885
Mmp25	-298	32
Mmp3	-1265	4045
Mmp9	1226	-6359
Ncstn	2223	347
Nid1	6799	4441
Phykpl	-2929	-717
Psen1	-309	-25
Scube1	6820	5249
Scube3	2333	4389
Spock3	6480	6467
Spp1	4125	6580
Timp1	7129	6798
Timp2	7029	5931
Tll1	5403	4589
Tll2	-784	-5372

---

---

Branched-chain-amino-acid-catabolism

Branched-chain-amino-acid-catabolism

metric	value
setSize	19
pMANOVA	5.85e-11
p.adjustMANOVA	2.49e-09
s.dist	1.22
s.young	-0.859
s.old	-0.871
p.young	9.04e-11
p.old	4.89e-11

Top 20 genes

Gene	young	old
Bckdha	-7342	-7803
Hibadh	-7283	-7717
Acat1	-7263	-7711
Dld	-7216	-7696
Mccc2	-7174	-7704
Ivd	-7138	-7712
Aldh6a1	-6998	-7778
Mccc1	-6826	-7722
Bckdhb	-6907	-7611
Bcat2	-6905	-7609
Auh	-6904	-7596
Ppm1k	-6684	-7715
Hsd17b10	-6937	-7410
Dbt	-6615	-7756
Hibch	-6982	-7198
Acad8	-6496	-7039
Acadsb	-5889	-7297
Bckdk	-6679	-6373

Click HERE to show all gene set members

All member genes

	young	old
Acad8	-6496	-7039
Acadsb	-5889	-7297
Acat1	-7263	-7711
Aldh6a1	-6998	-7778
Auh	-6904	-7596
Bcat1	4700	5242
Bcat2	-6905	-7609
Bckdha	-7342	-7803
Bckdhb	-6907	-7611
Bckdk	-6679	-6373
Dbt	-6615	-7756
Dld	-7216	-7696
Hibadh	-7283	-7717
Hibch	-6982	-7198
Hsd17b10	-6937	-7410
Ivd	-7138	-7712
Mccc1	-6826	-7722
Mccc2	-7174	-7704
Ppm1k	-6684	-7715

---

---

Glyoxylate-metabolism-and-glycine-degradation

Glyoxylate-metabolism-and-glycine-degradation

metric	value
setSize	25
pMANOVA	7.78e-11
p.adjustMANOVA	3.12e-09
s.dist	1.06
s.young	-0.751
s.old	-0.748
p.young	7.74e-11
p.old	9.53e-11

Top 20 genes

Gene	young	old
Bckdha	-7342	-7803
Dld	-7216	-7696
Dlst	-7165	-7693
Pdhx	-7172	-7679
Ndufab1	-7247	-7579
Pxmp2	-6949	-7658
Aldh4a1	-7153	-7436
Bckdhb	-6907	-7611
Pdhb	-7169	-7319
Ogdh	-7013	-7475
Pdha1	-7106	-7283
Dlat	-7003	-7332
Dbt	-6615	-7756
Got2	-6849	-6590
Lias	-6337	-6370
Gcsh	-4256	-7388
Ddo	-5929	-5213
Dhtkd1	-4047	-5919
Lipt2	-3800	-5935
Gnmt	-3686	-5324

Click HERE to show all gene set members

All member genes

	young	old
Aldh4a1	-7153	-7436
Amt	-5168	1070
Bckdha	-7342	-7803
Bckdhb	-6907	-7611
Dbt	-6615	-7756
Ddo	-5929	-5213
Dhtkd1	-4047	-5919
Dlat	-7003	-7332
Dld	-7216	-7696
Dlst	-7165	-7693
Gcsh	-4256	-7388
Gldc	-2462	1585
Gnmt	-3686	-5324
Got2	-6849	-6590
Grhpr	1747	-5672
Hoga1	-1971	695
Lias	-6337	-6370
Lipt1	-2499	-5036
Lipt2	-3800	-5935
Ndufab1	-7247	-7579
Ogdh	-7013	-7475
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Pxmp2	-6949	-7658

---

---

Elastic-fibre-formation

Elastic-fibre-formation

metric	value
setSize	38
pMANOVA	7.8e-11
p.adjustMANOVA	3.12e-09
s.dist	0.86
s.young	0.608
s.old	0.608
p.young	8.52e-11
p.old	8.68e-11

Top 20 genes

Gene	young	old
Tgfb2	7427	6986
Mfap5	7485	6861
Tgfb3	7433	6863
Loxl2	7336	6852
Loxl3	7361	6821
Ltbp3	7432	6685
Itga5	7309	6750
Itgav	7314	6700
Ltbp2	7174	6826
Lox	7364	6358
Mfap4	7221	6243
Fbln2	7256	6211
Bmp4	6772	6517
Loxl1	7313	5950
Ltbp4	7265	5969
Itgb5	7035	6117
Itgb3	7496	5721
Fbn1	6968	6107
Loxl4	6831	6223
Fbln5	6795	6253

Click HERE to show all gene set members

All member genes

	young	old
Bmp2	-2270	2145
Bmp4	6772	6517
Bmp7	-4799	-5293
Efemp1	-4901	-7119
Efemp2	6926	5475
Eln	5907	4689
Fbln1	-3620	3794
Fbln2	7256	6211
Fbln5	6795	6253
Fbn1	6968	6107
Fbn2	6918	5566
Furin	1738	-2954
Itga5	7309	6750
Itga8	3673	5405
Itgav	7314	6700
Itgb1	6770	5825
Itgb3	7496	5721
Itgb5	7035	6117
Itgb6	-4680	-6503
Itgb8	6492	6501
Lox	7364	6358
Loxl1	7313	5950
Loxl2	7336	6852
Loxl3	7361	6821
Loxl4	6831	6223
Ltbp1	2153	4810
Ltbp2	7174	6826
Ltbp3	7432	6685
Ltbp4	7265	5969
Mfap1b	2060	3988
Mfap2	7084	3420
Mfap3	919	-6
Mfap4	7221	6243
Mfap5	7485	6861
Tgfb1	6984	5531
Tgfb2	7427	6986
Tgfb3	7433	6863
Vtn	-7117	-7433

---

---

Assembly-of-collagen-fibrils-and-other-multimeric-structures

Assembly-of-collagen-fibrils-and-other-multimeric-structures

metric	value
setSize	46
pMANOVA	8.17e-11
p.adjustMANOVA	3.17e-09
s.dist	0.769
s.young	0.576
s.old	0.509
p.young	1.34e-11
p.old	2.38e-09

Top 20 genes

Gene	young	old
Col8a2	7452	6978
Col8a1	7519	6875
Col5a2	7480	6907
Lamc2	7360	6977
Loxl2	7336	6852
Loxl3	7361	6821
Col1a2	7362	6786
Col4a3	7037	6967
Col11a1	7093	6902
Col27a1	7356	6638
Col4a5	7202	6747
Pcolce	7373	6528
Col4a4	7049	6807
Col1a1	7237	6629
Col9a2	7498	6397
Lox	7364	6358
Col6a1	7176	6438
Col5a1	7233	6290
Col6a2	6971	6524
Bmp1	7236	6255

Click HERE to show all gene set members

All member genes

	young	old
Bmp1	7236	6255
Cd151	-3387	-2499
Col11a1	7093	6902
Col11a2	-1021	3528
Col15a1	6814	6634
Col18a1	6116	5391
Col1a1	7237	6629
Col1a2	7362	6786
Col27a1	7356	6638
Col3a1	6563	6455
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col4a5	7202	6747
Col5a1	7233	6290
Col5a2	7480	6907
Col5a3	2225	-2736
Col6a1	7176	6438
Col6a2	6971	6524
Col6a3	5781	6084
Col6a6	1479	-6594
Col8a1	7519	6875
Col8a2	7452	6978
Col9a2	7498	6397
Ctsb	-39	-2241
Ctss	3818	-193
Dst	5571	5573
Itga6	-5055	-3078
Itgb4	2528	3814
Lama3	1858	-436
Lamb3	-6638	-7066
Lamc2	7360	6977
Lox	7364	6358
Loxl1	7313	5950
Loxl2	7336	6852
Loxl3	7361	6821
Loxl4	6831	6223
Mmp13	-101	-5501
Mmp3	-1265	4045
Mmp9	1226	-6359
Pcolce	7373	6528
Plec	1669	2349
Pxdn	-3621	-6204
Tll1	5403	4589
Tll2	-784	-5372

---

---

Metabolism-of-lipids

Metabolism-of-lipids

metric	value
setSize	575
pMANOVA	1.26e-10
p.adjustMANOVA	4.72e-09
s.dist	0.191
s.young	-0.104
s.old	-0.16
p.young	2.19e-05
p.old	7.1e-11

Top 20 genes

Gene	young	old
Hadh	-7309	-7774
Acsl6	-7255	-7818
Acaa2	-7293	-7768
Eci1	-7341	-7716
Hadhb	-7300	-7759
Acot2	-7253	-7797
Decr1	-7267	-7777
Ptgr2	-7249	-7772
Echs1	-7313	-7662
Acat1	-7263	-7711
Phyh	-7261	-7709
Hadha	-7254	-7673
Crat	-7321	-7591
Dgat2	-7202	-7707
Ndufab1	-7247	-7579
Acad11	-7134	-7691
Acadvl	-7306	-7500
Acadm	-7198	-7598
Mmut	-7065	-7739
Pik3r1	-7121	-7646

Click HERE to show all gene set members

All member genes

	young	old
Aacs	4302	4629
Abca1	5067	-281
Abcb4	7210	6934
Abcc1	6729	6819
Abcc3	-27	473
Abcd1	-6190	-6228
Abhd3	-1534	-4787
Abhd4	6723	4307
Abhd5	-5259	-6321
Acaa2	-7293	-7768
Acaca	3453	-653
Acacb	-6936	-7366
Acad11	-7134	-7691
Acad12	-6749	-6851
Acadl	-6920	-7478
Acadm	-7198	-7598
Acads	-7280	-7250
Acadvl	-7306	-7500
Acat1	-7263	-7711
Acbd4	3015	4544
Acbd5	6712	4401
Acbd6	-5225	-2979
Acer2	3412	-4615
Acer3	-4605	-2376
Ache	2008	-1040
Acly	-3791	-3425
Acot11	-6459	-7215
Acot13	-7060	-7028
Acot2	-7253	-7797
Acot4	825	-4529
Acot6	3177	-2145
Acot7	-5971	-6960
Acot8	559	-172
Acot9	7045	6582
Acox1	-4724	-7321
Acox3	1630	-3864
Acp6	-6447	-7191
Acsf2	-5910	-7231
Acsf3	-6626	-7575
Acsl1	-6926	-7461
Acsl3	2818	-794
Acsl4	4513	954
Acsl5	3226	5103
Acsl6	-7255	-7818
Acss3	-6033	-5191
Agk	-4625	-6343
Agmo	3384	5619
Agpat1	-4882	-3988
Agpat2	-6388	-6657
Agpat3	-6640	-7071
Agpat4	4662	6089
Agpat5	-6415	-5448
Agps	-605	-2899
Agt	-4320	-6233
Ahr	-4294	-7324
Ahrr	-6799	-7285
Akr1b3	-6803	-6959
Alas1	-6613	-7012
Alb	-2631	1215
Aldh3a2	-30	-948
Aldh3b1	2547	2932
Alox12	-652	-4906
Alox5	-6090	-7663
Alox5ap	925	-623
Alox8	-2406	3609
Amacr	-6767	-7086
Angptl4	302	-3528
Ankrd1	7476	6925
Apoa1	-3117	-370
Apoa2	-4104	-1788
Arf1	-59	-3518
Arf3	6868	5063
Arnt	5880	5777
Arnt2	3608	3095
Arntl	4182	-1853
Arsa	3605	-897
Arsb	6684	5613
Arsg	5743	5658
Arsi	-5136	-5584
Arsj	-449	-2677
Arsk	5442	4251
Arv1	-108	210
Asah1	6043	3973
Asah2	1176	-4555
B3galnt1	5778	2318
B4galnt1	5962	6221
Bche	5266	6487
Bdh1	7034	-1618
Bdh2	-195	-88
Bmx	5463	1734
Carm1	-1701	-5594
Cav1	-5892	-7143
Cbr1	-5186	-6178
Cbr4	-6830	-7226
Ccnc	3190	2238
Cd36	-5986	-7614
Cdipt	-1066	1943
Cdk19	2454	4015
Cdk8	6754	5462
Cds1	4034	-6561
Cds2	-4274	-3035
Cept1	-4667	-4738
Cerk	1237	-682
Cers2	4517	5812
Cers4	775	433
Cers5	985	4266
Cers6	7092	3598
Ch25h	4808	3678
Chd9	6475	5594
Chka	4684	3845
Chkb	-6441	-7178
Chpt1	-7142	-6809
Cidea	837	295
Clock	2389	-3620
Cpne1	5193	4338
Cpne3	568	-3635
Cpne7	4472	1723
Cpt1a	3375	-3304
Cpt1b	-6751	-7032
Cpt2	-7007	-7546
Cptp	-650	-1108
Crat	-7321	-7591
Crebbp	-3332	-3533
Crls1	-2528	-6363
Crot	-1116	-3382
Csnk1g2	-1867	-1025
Csnk2a1	-6837	-7714
Csnk2a2	2827	-156
Csnk2b	-4627	-5569
Ctsa	3546	448
Cubn	-5532	-3322
Cyp1b1	7393	6028
Cyp27a1	4250	3986
Cyp2e1	-5364	1158
Cyp2r1	2096	2307
Cyp2u1	-6251	-6620
Cyp39a1	5373	3249
Cyp3a13	-7338	-6252
Cyp46a1	3175	2449
Cyp4b1	-6994	-6671
Cyp4f17	2111	2302
Cyp51	1692	-4686
Cyp7b1	-361	-1822
Dbi	-6324	-6808
Ddhd1	6916	6717
Ddhd2	3184	-3909
Decr1	-7267	-7777
Decr2	-2640	-3902
Degs2	-1416	993
Dgat1	-4190	-4756
Dgat2	-7202	-7707
Dhcr24	2696	5785
Dhcr7	-1331	-2195
Dhrs7b	701	2189
Dpep1	6542	-2015
Dpep2	2183	4844
Ebp	-4138	3561
Echs1	-7313	-7662
Eci1	-7341	-7716
Ehhadh	-5758	-7027
Elovl1	5112	5663
Elovl5	-3997	-5603
Elovl6	3634	2877
Elovl7	4758	-245
Enpp6	7214	5995
Ep300	-2809	-454
Ephx2	-6954	-7595
Esrra	-6804	-5371
Esyt1	4773	5394
Esyt2	4137	4086
Etnk1	-4063	-5539
Etnk2	-2993	2158
Faah	5123	5120
Fabp3	-5416	-6575
Fabp4	-2511	-7146
Fabp5	-285	-5130
Fads1	6269	5837
Fads2	6205	6018
Fam120b	-1758	590
Far1	5654	4954
Far2	-356	2061
Fasn	4789	4808
Fdft1	-6800	-7660
Fdps	-3157	-4647
Fdx1	-6618	-6735
Fhl2	-6336	-6536
Fig4	-5247	-5014
Fitm1	-7108	-6932
Fitm2	-6960	-7139
G0s2	-6461	-6515
Galc	5330	5745
Gba	6569	5896
Gba2	-5912	-4220
Gc	-2575	2559
Gde1	1830	1866
Gdpd1	-5391	-5869
Gdpd3	-300	692
Gdpd5	-6257	-7242
Ggps1	1607	787
Ggt5	-2340	-6497
Gla	4660	3638
Glb1	5822	1047
Glb1l	5086	5055
Glipr1	3778	4062
Gltp	3414	115
Gm20517	4105	-1043
Gm28042	-6038	-5882
Gm2a	4865	2353
Gnpat	-7105	-7547
Gpam	-6358	-7122
Gpat3	-6774	-7555
Gpat4	-1288	-3108
Gpcpd1	-5880	-7421
Gpd1	-7040	-7090
Gpd1l	-6427	-6200
Gpd2	-5217	-5433
Gps2	-776	1748
Gpx1	6364	6250
Gpx4	-5191	-4638
Gstm4	-132	-2249
H2-Ke6	-6180	-5754
Hacd1	-4729	1304
Hacd2	4010	-3297
Hacd3	3435	5413
Hacd4	5683	4021
Hadh	-7309	-7774
Hadha	-7254	-7673
Hadhb	-7300	-7759
Hdac3	-6017	-6749
Helz2	-4511	2213
Hexa	7315	6493
Hexb	5022	5616
Hilpda	4562	-2593
Hmgcl	-6101	-4870
Hmgcr	2226	985
Hmgcs1	-2407	-6353
Hmgcs2	-7290	-6929
Hpgd	4297	-3880
Hpgds	5206	2923
Hsd11b1	4943	-7273
Hsd17b11	1420	-5712
Hsd17b12	1383	3088
Hsd17b4	-6387	-7282
Hsd17b7	3825	2098
Hsd3b7	132	2489
Idi1	1349	-2423
Inpp4a	199	3915
Inpp4b	6154	6206
Inpp5d	2237	981
Inpp5e	-5981	-6551
Inpp5f	5077	6043
Inpp5j	6592	6670
Inpp5k	-3478	-3482
Inppl1	-889	4486
Insig1	2500	2552
Insig2	4839	3364
Kdsr	2324	4456
Kpnb1	-2201	-4623
Lbr	-4980	-6539
Lclat1	6246	4683
Lgmn	6758	4839
Lipe	-4226	-5925
Lpcat1	-3107	1624
Lpcat2	3656	4745
Lpcat3	-5695	-6527
Lpcat4	3445	1040
Lpgat1	-3466	-2218
Lpin1	-6854	-7150
Lpin2	3800	2781
Lpin3	5492	6403
Lss	3547	3820
Lta4h	5705	4468
Ltc4s	-2697	-1269
Mapkapk2	-6622	-6346
Mboat1	-1674	4442
Mboat2	7144	6699
Mboat7	3123	-1938
Mbtps1	5821	5093
Mbtps2	3160	465
Mcat	-6474	-6636
Mcee	-7015	-7616
Me1	-6765	-6942
Mecr	-6170	-6438
Med1	-2830	-5832
Med10	2803	2486
Med11	5462	1547
Med12	-281	4115
Med13	-2202	-3883
Med13l	-3236	-3463
Med14	461	807
Med15	5138	4459
Med16	-5864	-5683
Med17	797	-2935
Med18	77	-2735
Med19	-2688	-2878
Med21	-4100	-79
Med22	3056	-1594
Med23	-974	-3311
Med24	-1771	-3348
Med25	-3051	-2415
Med26	-5133	-1727
Med27	276	-880
Med28	-3615	-2070
Med29	-5417	-3040
Med30	4570	2236
Med31	-3053	-1604
Med4	-2448	-4093
Med6	2681	-1814
Med7	2798	-1801
Med8	1026	-396
Med9	1506	2554
Mgll	-4506	-7118
Mid1ip1	-5373	-4247
Miga1	-2284	-1905
Miga2	-6945	-6854
Mlycd	-6864	-7040
Mmaa	-6691	-6758
Mmut	-7065	-7739
Morc2b	1565	2940
Msmo1	4477	3773
Mtf1	-1900	-3101
Mtm1	-4334	-5378
Mtmr1	3788	958
Mtmr10	-4510	-3036
Mtmr12	4967	6598
Mtmr14	-1063	-2895
Mtmr2	-1866	-4271
Mtmr3	717	-3312
Mtmr4	-4330	-6504
Mtmr6	6520	4975
Mtmr7	1286	2328
Mtmr9	3730	-942
Mvd	-786	1263
Mvk	-841	881
Ncoa1	-4484	-6419
Ncoa2	-3912	-6801
Ncoa3	-6727	-4373
Ncoa6	-1555	-3479
Ncor1	-4730	-6152
Ncor2	4764	3742
Ndufab1	-7247	-7579
Neu1	-4503	-122
Neu3	-2654	-2701
Nfya	-3456	1336
Nfyb	-2643	-1716
Nfyc	-6029	-6006
Npas2	5604	-295
Nr1d1	1296	-175
Nr1h2	-243	1102
Nr1h3	-1853	-4977
Nr1h4	4445	220
Nrf1	2046	1078
Nsdhl	3643	3013
Nudt19	-6768	-6057
Nudt7	-6026	-7008
Ocrl	782	-3741
Ormdl2	-76	2290
Ormdl3	6163	2491
Osbp	-4631	-5804
Osbpl10	3404	-2455
Osbpl1a	-6498	-7356
Osbpl2	-5898	-6247
Osbpl3	2824	4437
Osbpl5	6889	6037
Osbpl6	-6391	-7399
Osbpl7	2072	2600
Osbpl8	1904	-1789
Osbpl9	4590	3483
Oxct1	-6455	-7560
Pcca	-7022	-7738
Pccb	-7054	-7359
Pctp	-3512	-6069
Pcyt1a	-3848	-5758
Pcyt1b	3225	-2052
Pcyt2	-6723	-7048
Pecr	-5886	-6147
Pemt	1711	3261
Pex11a	-6742	-7544
Pgs1	-2297	-164
Phospho1	-4307	-351
Phyh	-7261	-7709
Pi4k2a	5812	4741
Pi4k2b	6254	5089
Pi4ka	-4075	-5225
Pi4kb	-410	-2942
Pias4	-3508	-2197
Pik3c2a	-3001	-2146
Pik3c2b	-3537	-6207
Pik3c3	1891	-2240
Pik3ca	5242	5659
Pik3cb	3757	6013
Pik3cd	-120	1463
Pik3cg	4057	-374
Pik3r1	-7121	-7646
Pik3r2	7218	5112
Pik3r3	5367	1103
Pik3r4	480	-3782
Pik3r5	3057	3873
Pik3r6	-4434	-4988
Pikfyve	3766	3640
Pip4k2a	6260	5583
Pip4k2b	-575	-1112
Pip4k2c	207	-860
Pip5k1a	6376	5464
Pip5k1b	3999	-4337
Pip5k1c	3011	4725
Pitpnb	298	2242
Pitpnm1	244	1871
Pitpnm2	-6287	-2813
Pitpnm3	-5784	-7187
Pla1a	7199	6333
Pla2g12a	-3760	-6921
Pla2g15	32	-2369
Pla2g3	-2292	4799
Pla2g4a	7342	6860
Pla2g4e	-6588	-6369
Pla2g5	-6711	-7781
Pla2g6	-1374	-1982
Pla2r1	2134	2981
Plaat1	-6297	-6387
Plaat3	-5135	-6443
Plb1	-2327	-2998
Plbd1	-6752	-7782
Pld1	4581	4263
Pld2	-2706	-947
Pld3	6910	3086
Pld4	-1219	844
Plekha1	6078	6478
Plekha2	3712	-1730
Plekha3	3213	5560
Plekha4	7064	6689
Plekha5	-1282	-3486
Plekha6	6571	5910
Plekha8	611	1402
Plin1	-369	-3417
Plin2	-2436	-5931
Plin3	-6858	-7441
Plpp1	3994	6410
Plpp2	5311	4496
Plpp3	5504	6400
Plpp6	-4146	-6266
Pmvk	-4994	-4203
Pnpla2	-6697	-6659
Pnpla3	-2880	-773
Pnpla6	2839	3101
Pnpla7	-2916	-4735
Pnpla8	-6089	-6606
Pon2	7070	6950
Pon3	1714	1862
Ppara	-6545	-7563
Ppard	-5588	-4490
Pparg	-4842	-2722
Ppargc1a	-6363	-7511
Ppargc1b	-5894	-3355
Ppm1l	-6979	-7779
Ppp1ca	-2389	-1250
Ppp1cb	-6139	-5952
Ppp1cc	-3515	-5893
Ppt1	800	-4376
Ppt2	-5289	-5808
Prkaa2	-6100	-7414
Prkab2	7420	5930
Prkaca	-6075	-5990
Prkacb	3875	-3919
Prkag2	4029	-2192
Prkd1	-5984	-6614
Prkd2	-6209	-2620
Prkd3	2420	-501
Prxl2b	2509	-3979
Psap	-7208	-7432
Ptdss1	4612	2691
Ptdss2	-4069	-5792
Pten	679	-2222
Ptgds	6881	-7629
Ptges	-2486	1029
Ptges2	-7009	-6869
Ptges3	-3953	-1978
Ptgis	7197	6190
Ptgr1	3065	664
Ptgr2	-7249	-7772
Ptgs1	2392	1813
Ptgs2	5209	6187
Ptpmt1	-4962	-3166
Ptpn13	6035	6508
Rab14	-5276	-6634
Rab4a	1717	2240
Rab5a	5098	86
Rgl1	-2041	-3498
Rora	4753	1898
Rufy1	-5737	-5890
Rxra	-6194	-6804
Rxrb	-3171	-3373
Sacm1l	-113	-2718
Samd8	4496	-3754
Sar1b	-6848	-7206
Sbf1	1902	1414
Sbf2	-2928	-5674
Sc5d	-2682	-5398
Scap	4774	3684
Scd4	-6898	-6839
Scp2	-6736	-7268
Sec23a	4506	-802
Sec24a	-95	-2344
Sec24b	4189	3729
Sec24d	6468	5064
Selenoi	-2946	-5031
Sgms1	-4032	-4342
Sgms2	6615	6828
Sgpl1	6521	3504
Sgpp1	5844	970
Sin3a	625	-2529
Sin3b	467	164
Slc22a5	-6362	-7316
Slc25a1	6669	5317
Slc25a17	-336	-4956
Slc25a20	-6911	-7554
Slc27a1	-6130	-6336
Slc27a3	4118	4704
Slc44a1	5879	3779
Slc44a2	-4747	-2604
Slc44a5	-4245	434
Smarcd3	-4349	-759
Smpd1	-6969	-6721
Smpd2	-5709	-5563
Smpd3	4558	4699
Smpd4	-3589	-5217
Sp1	2620	521
Sphk1	6933	6215
Sphk2	-1665	-844
Sptlc1	2960	-1311
Sptlc2	4018	3419
Sptssa	-909	-3305
Sqle	4439	3886
Srd5a1	1673	1129
Srd5a3	4993	3726
Srebf1	5979	2962
Srebf2	1180	1001
Star	7459	7044
Stard10	4205	2960
Stard3	-4839	-3589
Stard3nl	2122	3211
Stard4	-1094	-3978
Stard5	-619	-2172
Stard6	4762	3926
Stard7	-6787	-7338
Sumf1	6244	3765
Sumo2	-1525	-5695
Synj1	2943	-3070
Synj2	996	-2290
Taz	-5545	-5487
Tbl1x	3008	-5102
Tbl1xr1	4225	-2715
Tbxas1	-921	2117
Tecr	-7151	-6741
Tecrl	-1100	5110
Tgs1	-4991	-5508
Them4	-5770	-5601
Thrap3	-2633	-3264
Thrsp	-5942	-5944
Tiam2	6979	6942
Tm7sf2	-406	177
Tmem86b	-4739	-1755
Tnfaip8	-6652	-7637
Tnfaip8l1	914	-2521
Tnfaip8l2	254	223
Tnfrsf21	-5776	-3833
Trib3	-3278	1445
Tspo	7491	6647
Txnrd1	-793	-2917
Ube2i	3577	1079
Ugcg	906	-4712
Vac14	3280	-355
Vapa	441	-3564
Vapb	-3523	-3980
Vdr	-724	-161

---

---

Formation-of-ATP-by-chemiosmotic-coupling

Formation-of-ATP-by-chemiosmotic-coupling

metric	value
setSize	16
pMANOVA	1.29e-10
p.adjustMANOVA	4.72e-09
s.dist	1.31
s.young	-0.933
s.old	-0.919
p.young	1.02e-10
p.old	1.89e-10

Top 20 genes

Gene	young	old
Atp5o	-7347	-7794
Atp5l	-7340	-7690
Atp5pb	-7213	-7607
Atp5g3	-7235	-7573
Atp5a1	-7220	-7504
Atp5c1	-7207	-7515
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5b	-7224	-7258
mt-Atp6	-7229	-7101
Atp5j2	-7093	-7135
Dmac2l	-6520	-7171
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5k	-5830	-7288
mt-Atp8	-3257	-6724

Click HERE to show all gene set members

All member genes

	young	old
Atp5a1	-7220	-7504
Atp5b	-7224	-7258
Atp5c1	-7207	-7515
Atp5d	-7173	-6303
Atp5e	-7150	-6015
Atp5g3	-7235	-7573
Atp5h	-7284	-7352
Atp5j	-7206	-7420
Atp5j2	-7093	-7135
Atp5k	-5830	-7288
Atp5l	-7340	-7690
Atp5o	-7347	-7794
Atp5pb	-7213	-7607
Dmac2l	-6520	-7171
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724

---

---

Intra-Golgi-and-retrograde-Golgi-to-ER-traffic

Intra-Golgi-and-retrograde-Golgi-to-ER-traffic

metric	value
setSize	168
pMANOVA	7.64e-10
p.adjustMANOVA	2.71e-08
s.dist	0.245
s.young	0.23
s.old	0.0831
p.young	2.68e-07
p.old	0.0636

Top 20 genes

Gene	young	old
Kif1a	7352	6987
Pla2g4a	7342	6860
Golim4	7319	6690
Arfgap3	7053	6800
Cyth3	7000	6420
Kif5c	6816	6381
Kdelr3	6958	6182
Kif5b	6829	6240
Rab3gap2	6715	6249
Golga4	7136	5783
Kif3b	6559	6252
Tmed3	6576	6027
Dync1li1	6485	5683
Kif3c	5698	6444
Kif26b	6048	6045
Kif11	5443	6537
Arf3	6868	5063
Usp6nl	5969	5710
Man1a2	5867	5756
Cenpe	6429	5244

Click HERE to show all gene set members

All member genes

	young	old
Actr10	-4042	-3915
Actr1a	3141	466
Agpat3	-6640	-7071
Arcn1	3459	-98
Arf1	-59	-3518
Arf3	6868	5063
Arf4	5304	4250
Arf5	2968	-1634
Arfgap1	1944	3018
Arfgap2	-4318	-3966
Arfgap3	7053	6800
Arfip2	787	2716
Arfrp1	-5846	-5542
Arl1	4219	-3201
Bet1l	5334	4588
Bicd1	5360	4677
Bicd2	2300	4029
Bnip1	-4721	-5553
Capza2	-2146	-4566
Capzb	-5179	-686
Cenpe	6429	5244
Cog1	3791	2760
Cog2	2381	-2488
Cog3	1640	-3468
Cog4	-3964	-4303
Cog5	-5907	-6472
Cog6	-3930	-6209
Cog7	-2722	-4763
Cog8	-6900	-7344
Copa	3741	-629
Copb1	5660	3885
Copb2	3538	-3332
Cope	-4431	-3559
Copg1	5827	4453
Copg2	968	-3951
Copz1	1326	-1220
Copz2	7011	4766
Cux1	6746	4816
Cyth1	-5817	-6706
Cyth2	5383	2969
Cyth3	7000	6420
Cyth4	536	-1578
Dctn1	-5873	-3219
Dctn2	-500	-3034
Dctn3	-591	-407
Dctn4	-5115	-6149
Dctn5	2992	-89
Dctn6	-5983	-6121
Dync1h1	2619	4531
Dync1i2	5203	4439
Dync1li1	6485	5683
Dync1li2	4461	5015
Dynll1	5075	5782
Dynll2	-6128	-5510
Galnt1	-866	-4743
Galnt2	5385	1538
Gbf1	-2279	-1916
Gcc1	4373	2954
Gcc2	4838	-874
Golga1	-1251	-80
Golga4	7136	5783
Golga5	4364	2357
Golim4	7319	6690
Gosr1	-1133	-2009
Gosr2	6073	-777
Igf2r	6292	-878
Kdelr1	3997	-4196
Kdelr2	5459	4436
Kdelr3	6958	6182
Kif11	5443	6537
Kif13b	750	3676
Kif15	2773	3536
Kif16b	-6047	-7444
Kif18a	5407	4955
Kif18b	3922	4124
Kif1a	7352	6987
Kif1b	-574	-2411
Kif1c	2439	-1206
Kif20a	3354	4533
Kif20b	5876	4188
Kif21a	-3345	-4447
Kif21b	3282	3606
Kif22	2609	3724
Kif23	4557	937
Kif26a	-3618	-6227
Kif26b	6048	6045
Kif2a	6321	-1561
Kif2c	5287	3465
Kif3a	4134	6220
Kif3b	6559	6252
Kif3c	5698	6444
Kif4	4235	4781
Kif5a	504	2105
Kif5b	6829	6240
Kif5c	6816	6381
Kif6	-5370	-6905
Kifap3	4639	-898
Kifc1	4168	3274
Kifc2	-3681	-4577
Klc1	5054	5911
Klc2	-5210	-4500
Klc4	774	-2078
M6pr	3239	-1497
Man1a	664	-2507
Man1a2	5867	5756
Man1c1	5900	2279
Man2a1	2682	1662
Man2a2	3550	-4096
Naa30	-2423	-4364
Naa35	2035	5767
Naa38	-5675	-5456
Napa	-5159	-4315
Napb	1860	6167
Napg	2133	3081
Nbas	-1485	-6584
Nsf	-957	-3637
Pafah1b1	-3476	-5904
Pafah1b2	5668	4043
Pafah1b3	5755	2487
Pla2g4a	7342	6860
Pla2g6	-1374	-1982
Plin3	-6858	-7441
Rab18	-1250	-4021
Rab1a	-3223	-6062
Rab1b	-6030	-5486
Rab30	-3630	-2354
Rab33b	6021	3134
Rab36	4621	4563
Rab3gap1	4350	3177
Rab3gap2	6715	6249
Rab43	4039	2459
Rab6a	6083	2806
Rab6b	4327	1836
Rab9	-2739	-6338
Rabepk	-2337	-3341
Racgap1	4251	3966
Rgp1	-2686	-1308
Rhobtb3	5831	-4485
Ric1	-3551	-4586
Rint1	-2096	-4150
Scoc	-3939	-5162
Sec22b	5609	3487
Snap29	-5199	-6114
Stx16	4933	-115
Stx18	3628	-452
Stx5a	4418	3544
Stx6	4375	3057
Surf4	4872	-1590
Tgoln1	-601	-3932
Tmed10	5429	480
Tmed2	4476	-272
Tmed3	6576	6027
Tmed7	-747	-6167
Tmed9	3775	-3777
Tmf1	5476	2253
Trip11	-2178	-3383
Use1	3639	2259
Usp6nl	5969	5710
Vamp3	1340	209
Vamp4	4015	3390
Vps45	3111	3511
Vps51	3780	1101
Vps52	-4155	-3552
Vps53	2432	1700
Vps54	-2623	3076
Vti1a	2869	-1116
Ykt6	4836	-818
Zw10	4767	6235

---

---

tRNA-processing-in-the-mitochondrion

tRNA-processing-in-the-mitochondrion

metric	value
setSize	18
pMANOVA	3.43e-09
p.adjustMANOVA	1.18e-07
s.dist	1.13
s.young	-0.75
s.old	-0.842
p.young	3.52e-08
p.old	6.26e-10

Top 20 genes

Gene	young	old
mt-Co1	-7257	-7632
mt-Nd2	-7271	-7495
mt-Nd1	-7119	-7489
mt-Cytb	-6947	-7620
Hsd17b10	-6937	-7410
mt-Atp6	-7229	-7101
mt-Co3	-7307	-7023
mt-Nd4	-6682	-7382
mt-Nd6	-6677	-7251
mt-Nd5	-6386	-7564
mt-Co2	-7163	-6523
mt-Nd3	-6642	-5922
Trmt10c	-5141	-6714
mt-Nd4l	-3936	-7494
mt-Atp8	-3257	-6724
Elac2	-4160	-4011

Click HERE to show all gene set members

All member genes

	young	old
Elac2	-4160	-4011
Hsd17b10	-6937	-7410
mt-Atp6	-7229	-7101
mt-Atp8	-3257	-6724
mt-Co1	-7257	-7632
mt-Co2	-7163	-6523
mt-Co3	-7307	-7023
mt-Cytb	-6947	-7620
mt-Nd1	-7119	-7489
mt-Nd2	-7271	-7495
mt-Nd3	-6642	-5922
mt-Nd4	-6682	-7382
mt-Nd4l	-3936	-7494
mt-Nd5	-6386	-7564
mt-Nd6	-6677	-7251
Prorp	1087	-5691
Trmt10c	-5141	-6714
Trnt1	238	-2405

---

---

Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)

Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)

metric	value
setSize	84
pMANOVA	4.05e-09
p.adjustMANOVA	1.36e-07
s.dist	0.521
s.young	0.389
s.old	0.347
p.young	7.59e-10
p.old	3.74e-08

Top 20 genes

Gene	young	old
Fstl3	7499	6931
Mmp2	7497	6885
Qsox1	7490	6703
Sdc2	7435	6631
Mxra8	7331	6704
Itih2	7098	6851
Igfbp7	7321	6623
Timp1	7129	6798
Fstl1	7372	6531
Vcan	7188	6694
Fn1	7320	6491
Fam20c	7283	6382
Fam20a	6769	6705
Cp	6527	6899
Igfbp6	6676	6725
Ckap4	7111	6291
C4b	6877	6457
Bmp4	6772	6517
Lamc1	7347	5936
Igf1	7240	5920

Click HERE to show all gene set members

All member genes

	young	old
Adam10	5268	3108
Ahsg	4752	6702
Alb	-2631	1215
Ano8	-4679	-4635
Aplp2	1887	-5547
Apoa1	-3117	-370
Apoa2	-4104	-1788
Apob	-2312	1254
Apoe	948	-334
App	6494	6345
Bmp4	6772	6517
C3	-1415	-6719
C4b	6877	6457
Calu	6531	4815
Cdh2	5636	2941
Chrdl1	742	2722
Ckap4	7111	6291
Cp	6527	6899
Csf1	-242	4128
Cst3	5893	5471
Dnajc3	-3010	-2409
Eva1a	-3372	-3104
Fam20a	6769	6705
Fam20c	7283	6382
Fbn1	6968	6107
Fga	-3043	855
Fn1	7320	6491
Fstl1	7372	6531
Fstl3	7499	6931
Fuca2	-5682	-4877
Gas6	2658	4026
Golm1	4890	-2511
Gpc3	2127	-5769
Hrc	-7166	-7731
Hsp90b1	-5033	-5785
Igf1	7240	5920
Igf2	768	-5914
Igfals	-6489	-7076
Igfbp3	-4647	-837
Igfbp4	6397	-513
Igfbp5	4815	2528
Igfbp6	6676	6725
Igfbp7	7321	6623
Itih2	7098	6851
Ktn1	3908	-169
Lamb1	6771	-983
Lamb2	2375	4485
Lamc1	7347	5936
Lgals1	7095	3320
Ltbp1	2153	4810
Mbtps1	5821	5093
Men1	-3828	-2806
Mfge8	5789	4710
Mgat4a	2446	753
Mia3	5790	3806
Mmp2	7497	6885
Msln	2360	-3630
Mxra8	7331	6704
Nucb1	5146	-1685
P4hb	6441	4378
Pappa	5106	5735
Pappa2	2103	2774
Pdia6	-3081	-4513
Penk	-5937	-6873
Pnpla2	-6697	-6659
Prkcsh	2629	2190
Prss23	4876	2314
Qsox1	7490	6703
Scg3	6324	4487
Sdc2	7435	6631
Serpina1d	-3938	1913
Serpinc1	-2974	1289
Shisa5	3383	5045
Sparcl1	5012	6004
Spp1	4125	6580
Stc2	3421	3269
Tgoln1	-601	-3932
Timp1	7129	6798
Tmem132a	6428	5094
Tnc	4757	6330
Trf	5836	4229
Vcan	7188	6694
Vwa1	6270	5237
Wfs1	6267	3063

---

---

Asparagine-N-linked-glycosylation

Asparagine-N-linked-glycosylation

metric	value
setSize	251
pMANOVA	7.8e-09
p.adjustMANOVA	2.56e-07
s.dist	0.114
s.young	0.111
s.old	-0.0245
p.young	0.00251
p.old	0.505

Top 20 genes

Gene	young	old
Mgat3	4996	-6874
St3gal4	4466	-4957
Rft1	3829	-5039
Kdelr1	3997	-4196
Man2a2	3550	-4096
Tmed9	3775	-3777
Sec23ip	4637	-3059
Mcfd2	2584	-5058
Copb2	3538	-3332
St6galnac2	5684	-2059
Trappc6a	3326	-3504
Ubb	5763	-1908
St6gal1	4351	-2022
Fut8	5119	-1697
Dpm3	1522	-4346
Manea	3695	-1706
Cog2	2381	-2488
Cog3	1640	-3468
Ganab	3151	-1625
Arf5	2968	-1634

Click HERE to show all gene set members

All member genes

	young	old
Actr10	-4042	-3915
Actr1a	3141	466
Alg1	6726	5694
Alg10b	-4303	-7294
Alg11	-1229	-3115
Alg12	-2699	-3881
Alg14	474	3160
Alg2	-518	-1267
Alg3	-322	-2230
Alg5	5916	5071
Alg6	-1841	-4848
Alg8	1524	339
Alg9	-2204	-6400
Amdhd2	4916	2058
Amfr	5931	4520
Ank1	-6868	-6830
Ank2	-6606	-7276
Ank3	-2630	2172
Ankrd28	6460	6474
Arcn1	3459	-98
Arf1	-59	-3518
Arf3	6868	5063
Arf4	5304	4250
Arf5	2968	-1634
Arfgap1	1944	3018
Arfgap2	-4318	-3966
Arfgap3	7053	6800
B4galt1	3267	1068
B4galt2	6315	4664
B4galt3	-4310	-1405
B4galt4	-4249	-652
B4galt5	6407	5561
B4galt6	6036	6103
Bet1l	5334	4588
Calr	-3747	-4997
Canx	-5693	-7105
Capza2	-2146	-4566
Capzb	-5179	-686
Cd59b	-5550	-3313
Chst10	4959	4476
Cmas	3263	831
Cnih1	-1321	-2923
Cnih2	383	-104
Cog1	3791	2760
Cog2	2381	-2488
Cog3	1640	-3468
Cog4	-3964	-4303
Cog5	-5907	-6472
Cog6	-3930	-6209
Cog7	-2722	-4763
Cog8	-6900	-7344
Copa	3741	-629
Copb1	5660	3885
Copb2	3538	-3332
Cope	-4431	-3559
Copg1	5827	4453
Copg2	968	-3951
Copz1	1326	-1220
Copz2	7011	4766
Csnk1d	5455	4161
Ctsa	3546	448
Ctsc	-3996	-6450
Ctsz	6955	6572
Dad1	3002	2211
Dctn1	-5873	-3219
Dctn2	-500	-3034
Dctn3	-591	-407
Dctn4	-5115	-6149
Dctn5	2992	-89
Dctn6	-5983	-6121
Ddost	5379	-181
Derl1	1222	-3922
Derl2	-2315	-4575
Dhdds	4837	4695
Dolk	-5587	-3086
Dolpp1	921	-3874
Dpagt1	-2089	-1947
Dpm1	-1101	-5227
Dpm2	4502	2233
Dpm3	1522	-4346
Dync1h1	2619	4531
Dync1i2	5203	4439
Dync1li1	6485	5683
Dync1li2	4461	5015
Dynll1	5075	5782
Dynll2	-6128	-5510
Edem1	486	4895
Edem2	4007	4169
Edem3	4895	3637
Engase	-3058	-2856
F8	-1506	592
Fcsk	1861	-708
Fpgt	1415	-71
Fuca1	5465	3412
Fuom	-6371	-3820
Fut8	5119	-1697
Ganab	3151	-1625
Gbf1	-2279	-1916
Gfpt1	4092	919
Gfpt2	-5090	1134
Glb1	5822	1047
Gm11808	-5706	-216
Gmds	3531	4447
Gmppa	3080	1628
Gmppb	1721	2324
Gne	1172	-1633
Gnpnat1	4972	1038
Golgb1	6598	6059
Gorasp1	273	-4434
Gosr1	-1133	-2009
Gosr2	6073	-777
Kdelr1	3997	-4196
Kdelr2	5459	4436
Kdelr3	6958	6182
Lman1	-1130	-5060
Lman1l	5574	5946
Lman2	-2352	-4702
Lman2l	-4616	-4849
Magt1	-5441	-7480
Man1a	664	-2507
Man1a2	5867	5756
Man1b1	-176	-2291
Man1c1	5900	2279
Man2a1	2682	1662
Man2a2	3550	-4096
Manea	3695	-1706
Mcfd2	2584	-5058
Mgat1	1031	-2321
Mgat2	5212	2395
Mgat3	4996	-6874
Mgat4a	2446	753
Mgat4b	-4283	-4924
Mgat5	-1543	-3594
Mia2	-5629	-7819
Mia3	5790	3806
Mlec	-932	-5239
Mogs	2989	-751
Mpdu1	5512	3468
Mpi	-7175	-6989
Mvd	-786	1263
Nagk	3592	-731
Nanp	2835	1684
Nans	6392	4932
Napa	-5159	-4315
Napb	1860	6167
Napg	2133	3081
Neu1	-4503	-122
Neu3	-2654	-2701
Ngly1	845	711
Npl	2978	1243
Nsf	-957	-3637
Nudt14	-7278	-7587
Nus1	1719	-1890
Os9	4038	2735
Pdia3	2332	353
Pgm3	5901	4554
Pmm1	7486	6895
Pmm2	-3323	-5784
Ppp6c	-3624	-5684
Ppp6r1	-5185	-4073
Ppp6r3	-5054	-6661
Preb	-5765	-4262
Prkcsh	2629	2190
Psmc1	-4509	-1482
Rab1a	-3223	-6062
Rab1b	-6030	-5486
Rad23b	-4644	-4605
Renbp	4245	2617
Rft1	3829	-5039
Rnf103	6849	6352
Rnf139	-5444	-5644
Rnf185	-3305	-2631
Rnf5	-5268	-4979
Rpn1	-584	-2591
Rpn2	2811	1591
Rps27a	-1504	-1029
Sar1b	-6848	-7206
Scfd1	2215	832
Sec13	1575	39
Sec16a	572	-4601
Sec16b	7226	6671
Sec22a	-1779	-5709
Sec22b	5609	3487
Sec22c	4146	194
Sec23a	4506	-802
Sec23ip	4637	-3059
Sec24a	-95	-2344
Sec24b	4189	3729
Sec24d	6468	5064
Sec31a	1581	2182
Sel1l	3457	1172
Serpina1d	-3938	1913
Slc17a5	4456	2342
Slc35a1	4230	111
Slc35c1	2466	1410
Spta1	-2545	-5699
Sptan1	-525	5294
Sptb	-1715	1502
Sptbn1	-4084	-4692
Sptbn2	-1231	1110
Sptbn5	3367	6778
Srd5a3	4993	3726
St3gal1	3058	716
St3gal2	6995	5852
St3gal3	-6777	-6624
St3gal4	4466	-4957
St3gal5	5507	3409
St3gal6	-4673	-4593
St6gal1	4351	-2022
St6galnac2	5684	-2059
St6galnac3	48	-5018
St6galnac4	6331	6062
St6galnac6	-7184	-7584
St8sia1	6367	6714
St8sia2	4491	4888
St8sia4	-6404	-5155
St8sia6	-1521	-4549
Stt3a	6426	4330
Stx17	759	-2924
Stx5a	4418	3544
Syvn1	250	-3418
Tbc1d20	3878	3019
Tfg	-1929	-4911
Tgfa	6309	4116
Tmed10	5429	480
Tmed2	4476	-272
Tmed3	6576	6027
Tmed7	-747	-6167
Tmed9	3775	-3777
Tmem115	-2170	-121
Trappc1	-3692	-2484
Trappc10	-5862	-6859
Trappc2l	-5623	-3826
Trappc3	-2835	-4059
Trappc4	-2363	396
Trappc5	-2308	-3230
Trappc6a	3326	-3504
Trappc6b	1361	1137
Trappc9	-4762	-5251
Trim13	-751	2199
Tsta3	-4656	-3516
Tusc3	5313	4277
Uap1	-4914	-3592
Ubb	5763	-1908
Ubc	-1436	-1699
Ubxn1	6883	5851
Uggt1	2756	1971
Uggt2	4732	4979
Uso1	6091	4331
Vcp	-2921	-3485
Ykt6	4836	-818

---

---

Chondroitin-sulfate/dermatan-sulfate-metabolism

Chondroitin-sulfate/dermatan-sulfate-metabolism

metric	value
setSize	42
pMANOVA	1.03e-08
p.adjustMANOVA	3.3e-07
s.dist	0.707
s.young	0.54
s.old	0.456
p.young	1.42e-09
p.old	3.11e-07

Top 20 genes

Gene	young	old
Bgn	7481	6830
Cspg4	7500	6779
Dcn	7414	6701
Sdc2	7435	6631
Dse	7298	6706
Dsel	7222	6720
Vcan	7188	6694
Hexa	7315	6493
Chpf2	6949	6362
Gpc6	6891	6273
Chpf	7328	5652
Chsy1	7110	5672
Chsy3	6387	6260
Chst3	6451	6127
Ust	6358	6176
Csgalnact2	6411	5972
Xylt1	6328	6030
Arsb	6684	5613
Sdc1	7061	4784
Ids	6784	4640

Click HERE to show all gene set members

All member genes

	young	old
Agrn	-247	199
Arsb	6684	5613
B3galt6	4154	3582
B3gat2	2242	2141
B3gat3	-677	-1460
B4galt7	-1177	-3787
Bgn	7481	6830
Chpf	7328	5652
Chpf2	6949	6362
Chst11	1137	4315
Chst12	4324	4171
Chst14	5647	3716
Chst15	-359	-4584
Chst3	6451	6127
Chst7	1335	-705
Chsy1	7110	5672
Chsy3	6387	6260
Csgalnact1	2042	-2352
Csgalnact2	6411	5972
Cspg4	7500	6779
Cspg5	-3048	1942
Dcn	7414	6701
Dse	7298	6706
Dsel	7222	6720
Gpc1	-3801	-4293
Gpc3	2127	-5769
Gpc4	-3619	-6582
Gpc6	6891	6273
Hexa	7315	6493
Hexb	5022	5616
Hspg2	6535	3769
Hyal1	4392	6096
Ids	6784	4640
Idua	-5121	-5157
Sdc1	7061	4784
Sdc2	7435	6631
Sdc3	4012	3827
Sdc4	4355	-9
Ust	6358	6176
Vcan	7188	6694
Xylt1	6328	6030
Xylt2	2935	-1769

---

---

Interferon-alpha/beta-signaling

Interferon-alpha/beta-signaling

metric	value
setSize	40
pMANOVA	1.39e-08
p.adjustMANOVA	4.33e-07
s.dist	0.363
s.young	0.0479
s.old	0.36
p.young	0.601
p.old	8.18e-05

Top 20 genes

Gene	young	old
Irf5	6574	5961
Ip6k2	5972	5125
Irf8	6762	4110
Ifit2	4223	6292
Ifit3b	4145	5674
Oas3	4123	5233
Ptpn1	4586	4701
Egr1	6800	2934
Tyk2	3861	4516
Ifnar1	4856	3153
Mx1	2461	4874
Isg15	1534	5220
Socs1	1854	3043
Psmb8	188	2895
Irf2	20	1727

Click HERE to show all gene set members

All member genes

	young	old
Abce1	-693	-1645
Adar	-1009	3485
Bst2	-4223	4477
Egr1	6800	2934
Ifi35	-3130	4433
Ifit2	4223	6292
Ifit3b	4145	5674
Ifnar1	4856	3153
Ifnar2	2104	-5943
Ip6k2	5972	5125
Irf1	-3783	-2366
Irf2	20	1727
Irf3	-2892	-808
Irf4	-4725	-5939
Irf5	6574	5961
Irf6	2842	-1207
Irf7	-70	6216
Irf8	6762	4110
Irf9	-611	5700
Isg15	1534	5220
Isg20	-1498	4375
Jak1	-2505	-6853
Mx1	2461	4874
Oas2	-1450	4847
Oas3	4123	5233
Oasl1	-8	5668
Psmb8	188	2895
Ptpn1	4586	4701
Ptpn11	-3358	-3525
Ptpn6	-2833	1877
Rnasel	4220	-1796
Rsad2	-6088	1479
Samhd1	-4358	-5556
Socs1	1854	3043
Socs3	2520	-1464
Stat1	-1595	3287
Stat2	-3094	5004
Tyk2	3861	4516
Usp18	-2557	6813
Xaf1	-1484	5451

---

---

Membrane-Trafficking

Membrane-Trafficking

metric	value
setSize	530
pMANOVA	1.5e-08
p.adjustMANOVA	4.57e-07
s.dist	0.105
s.young	0.103
s.old	0.0175
p.young	5.05e-05
p.old	0.493

Top 20 genes

Gene	young	old
Rab27b	7417	6961
Kif1a	7352	6987
Hbegf	7493	6774
Snap91	7297	6913
Pla2g4a	7342	6860
Dnm1	7467	6740
Tpd52	7337	6711
Golim4	7319	6690
Src	7196	6795
Rab31	7227	6762
Sh3d19	7205	6726
Sec16b	7226	6671
Arfgap3	7053	6800
Cttn	7225	6511
Ctsz	6955	6572
Cyth3	7000	6420
Syt11	7329	6053
Prkab2	7420	5930
Ereg	7082	6195
Rab13	6900	6349

Click HERE to show all gene set members

All member genes

	young	old
Aak1	-4106	-4972
Acbd3	2132	3045
Actr10	-4042	-3915
Actr1a	3141	466
Actr2	3943	842
Actr3	6464	4364
Adrb2	-1509	-2331
Agfg1	4755	5536
Agpat3	-6640	-7071
Akt1	-6210	-5765
Akt2	-7113	-6780
Akt3	2614	4706
Als2	-3840	-4691
Als2cl	-5966	-3827
Amph	-169	-3023
Ank1	-6868	-6830
Ank2	-6606	-7276
Ank3	-2630	2172
Ankrd27	6124	3553
Ankrd28	6460	6474
Ap1b1	-5995	-6810
Ap1g1	-2167	-2801
Ap1g2	2734	5025
Ap1m1	-2470	-5561
Ap1s1	5440	3557
Ap1s2	5488	5457
Ap1s3	408	2693
Ap2a1	4766	-1188
Ap2a2	1207	-4356
Ap2b1	5061	4756
Ap2m1	1964	309
Ap2s1	1934	322
Ap3b1	5445	4096
Ap3s1	6518	3518
Ap4e1	1365	1166
Ap4m1	4271	633
Ap4s1	-6579	-4813
Apob	-2312	1254
App	6494	6345
Arcn1	3459	-98
Arf1	-59	-3518
Arf3	6868	5063
Arf4	5304	4250
Arf5	2968	-1634
Arf6	5964	4802
Arfgap1	1944	3018
Arfgap2	-4318	-3966
Arfgap3	7053	6800
Arfip2	787	2716
Arfrp1	-5846	-5542
Arl1	4219	-3201
Arpc1a	1275	-1289
Arpc2	6342	4176
Arpc3	4578	4114
Arpc4	5956	2991
Arpc5	5253	3164
Arrb1	6454	5029
Arrb2	2854	2025
Aspscr1	6566	4592
Bet1l	5334	4588
Bicd1	5360	4677
Bicd2	2300	4029
Bin1	2868	6818
Bloc1s1	-6740	-5818
Bloc1s3	4161	159
Bloc1s4	343	-642
Bloc1s6	4193	3922
Bnip1	-4721	-5553
Btc	3998	3938
C2cd5	-1615	241
Calm1	-4595	-4970
Capza2	-2146	-4566
Capzb	-5179	-686
Cbl	2363	821
Ccz1	6818	1385
Cd3d	-417	-312
Cd4	-2571	-2169
Cd59b	-5550	-3313
Cenpe	6429	5244
Chm	4576	910
Chml	4934	6307
Chmp2a	1793	-1096
Chmp2b	1232	-1104
Chmp3	6948	5512
Chmp4b	5717	1200
Chmp4c	6803	4718
Chmp5	3696	136
Chmp6	1760	-423
Chmp7	3831	4757
Chrm2	-3866	-3729
Clint1	5780	908
Clta	2287	-631
Cltb	6447	5854
Cltc	2485	6
Cnih1	-1321	-2923
Cnih2	383	-104
Cog1	3791	2760
Cog2	2381	-2488
Cog3	1640	-3468
Cog4	-3964	-4303
Cog5	-5907	-6472
Cog6	-3930	-6209
Cog7	-2722	-4763
Cog8	-6900	-7344
Copa	3741	-629
Copb1	5660	3885
Copb2	3538	-3332
Cope	-4431	-3559
Copg1	5827	4453
Copg2	968	-3951
Cops2	3345	-2086
Cops3	-4305	-5384
Cops4	-3918	-1816
Cops5	-4403	-5437
Cops6	-5787	-5427
Cops7a	-2517	-2882
Cops7b	-537	-291
Cops8	-5408	-5033
Copz1	1326	-1220
Copz2	7011	4766
Cpd	6006	6688
Csnk1d	5455	4161
Ctsc	-3996	-6450
Ctsz	6955	6572
Cttn	7225	6511
Cux1	6746	4816
Cyth1	-5817	-6706
Cyth2	5383	2969
Cyth3	7000	6420
Cyth4	536	-1578
Dab2	5377	3411
Dctn1	-5873	-3219
Dctn2	-500	-3034
Dctn3	-591	-407
Dctn4	-5115	-6149
Dctn5	2992	-89
Dctn6	-5983	-6121
Dennd1a	-3834	-5238
Dennd1b	-1530	1678
Dennd1c	-3480	-2470
Dennd2a	6844	5576
Dennd2c	-4692	-3256
Dennd2d	4093	2364
Dennd3	-6241	-3522
Dennd4a	5637	6344
Dennd4b	-6467	-5983
Dennd4c	-3905	-7170
Dennd5a	4356	4873
Dennd5b	-4417	-4117
Dennd6a	-877	-1347
Dennd6b	-5378	-2351
Dnase2a	5652	6289
Dnm1	7467	6740
Dnm2	-4130	324
Dnm3	-1732	3166
Dtnbp1	-6883	-7158
Dvl2	5014	-1883
Dync1h1	2619	4531
Dync1i2	5203	4439
Dync1li1	6485	5683
Dync1li2	4461	5015
Dynll1	5075	5782
Dynll2	-6128	-5510
Egf	-5607	-6796
Egfr	6827	4231
Epn1	-6564	-4868
Epn2	-3152	-3544
Eps15	4596	4742
Eps15l1	-5775	-6626
Ereg	7082	6195
Exoc1	5938	5433
Exoc2	2456	-1179
Exoc3	-5576	-5746
Exoc4	5248	5325
Exoc5	5055	3118
Exoc6	-5248	-6974
Exoc7	-3011	-2611
Exoc8	-4733	-4562
F8	-1506	592
Fcho2	-3325	-1824
Fnbp1	280	-2209
Fnbp1l	-6107	-6940
Fth1	-6984	-6689
Fzd4	-3807	-5670
Gabarap	3004	762
Gabarapl2	-1459	-1609
Gak	905	1705
Galnt1	-866	-4743
Galnt2	5385	1538
Gapvd1	-3983	-4411
Gbf1	-2279	-1916
Gcc1	4373	2954
Gcc2	4838	-874
Gdi1	-1923	2493
Gdi2	5610	3130
Gga1	-3748	-2504
Gga2	3490	5354
Gga3	-4565	-2465
Gja3	-5960	-6756
Gja4	4489	938
Gja5	2759	713
Gjc1	2184	5758
Gjc2	6702	4801
Gm11808	-5706	-216
Gns	-4478	-5630
Golga1	-1251	-80
Golga4	7136	5783
Golga5	4364	2357
Golgb1	6598	6059
Golim4	7319	6690
Gorasp1	273	-4434
Gosr1	-1133	-2009
Gosr2	6073	-777
Gps1	2514	-690
Grb2	-4590	-3819
Grk2	-5236	-5006
Grk3	2707	2012
Hbegf	7493	6774
Hgs	4975	3859
Hip1	5040	6331
Hip1r	-1687	669
Hps1	5310	4973
Hps4	-450	-1520
Hspa8	-5126	-2542
Igf2r	6292	-878
Itsn1	946	-1939
Itsn2	-3761	822
Kdelr1	3997	-4196
Kdelr2	5459	4436
Kdelr3	6958	6182
Kif11	5443	6537
Kif13b	750	3676
Kif15	2773	3536
Kif16b	-6047	-7444
Kif18a	5407	4955
Kif18b	3922	4124
Kif1a	7352	6987
Kif1b	-574	-2411
Kif1c	2439	-1206
Kif20a	3354	4533
Kif20b	5876	4188
Kif21a	-3345	-4447
Kif21b	3282	3606
Kif22	2609	3724
Kif23	4557	937
Kif26a	-3618	-6227
Kif26b	6048	6045
Kif2a	6321	-1561
Kif2c	5287	3465
Kif3a	4134	6220
Kif3b	6559	6252
Kif3c	5698	6444
Kif4	4235	4781
Kif5a	504	2105
Kif5b	6829	6240
Kif5c	6816	6381
Kif6	-5370	-6905
Kifap3	4639	-898
Kifc1	4168	3274
Kifc2	-3681	-4577
Klc1	5054	5911
Klc2	-5210	-4500
Klc4	774	-2078
Ldlr	4127	4914
Ldlrap1	-211	-1969
Lman1	-1130	-5060
Lman1l	5574	5946
Lman2	-2352	-4702
Lman2l	-4616	-4849
Lnpep	2021	4145
M6pr	3239	-1497
Madd	-5791	-4960
Man1a	664	-2507
Man1a2	5867	5756
Man1c1	5900	2279
Man2a1	2682	1662
Man2a2	3550	-4096
Map1lc3b	-6279	-7247
Mcfd2	2584	-5058
Mia2	-5629	-7819
Mia3	5790	3806
Mon1a	-2647	1251
Mon1b	1785	1177
Mvb12a	-4581	-3590
Mvb12b	2144	-1272
Myh9	4478	4696
Myo1c	3674	3464
Myo5a	6359	5343
Myo6	-2507	-921
Naa30	-2423	-4364
Naa35	2035	5767
Naa38	-5675	-5456
Napa	-5159	-4315
Napb	1860	6167
Napg	2133	3081
Nbas	-1485	-6584
Necap1	1847	-1243
Necap2	4265	3227
Nedd8	95	641
Nsf	-957	-3637
Ocrl	782	-3741
Optn	-6274	-7401
Pacsin2	-6962	-7292
Pacsin3	5300	2609
Pafah1b1	-3476	-5904
Pafah1b2	5668	4043
Pafah1b3	5755	2487
Picalm	-2717	3439
Pik3c2a	-3001	-2146
Pip5k1c	3011	4725
Pla2g4a	7342	6860
Pla2g6	-1374	-1982
Plin3	-6858	-7441
Polg	-5193	-4833
Ppp6c	-3624	-5684
Ppp6r1	-5185	-4073
Ppp6r3	-5054	-6661
Preb	-5765	-4262
Prkaa2	-6100	-7414
Prkab1	-4034	-7255
Prkab2	7420	5930
Prkag1	-6213	-4030
Prkag2	4029	-2192
Prkag3	5303	4957
Pum1	-1396	-1790
Rab10	-4439	-5212
Rab11a	-2501	-5885
Rab11b	1212	-3386
Rab12	-5280	-6895
Rab13	6900	6349
Rab14	-5276	-6634
Rab18	-1250	-4021
Rab1a	-3223	-6062
Rab1b	-6030	-5486
Rab21	-4812	-6186
Rab27a	-1179	-3721
Rab27b	7417	6961
Rab30	-3630	-2354
Rab31	7227	6762
Rab33b	6021	3134
Rab35	5336	845
Rab36	4621	4563
Rab3a	-6304	-4824
Rab3gap1	4350	3177
Rab3gap2	6715	6249
Rab3il1	6333	4912
Rab3ip	-6514	-7168
Rab43	4039	2459
Rab4a	1717	2240
Rab5a	5098	86
Rab5b	-1911	-4750
Rab5c	3142	-1160
Rab6a	6083	2806
Rab6b	4327	1836
Rab7	-5369	-6377
Rab7b	6565	5190
Rab8a	1372	1357
Rab8b	4850	2440
Rab9	-2739	-6338
Rabep1	2875	5000
Rabepk	-2337	-3341
Rabgap1	2612	817
Rabgef1	-85	-2941
Rac1	328	-2928
Racgap1	4251	3966
Rala	-696	-1429
Ralgapa2	-6880	-7729
Ralgapb	-4179	-6708
Reps1	1577	-1085
Reps2	1370	-3943
Rgp1	-2686	-1308
Rhobtb3	5831	-4485
Rhoq	-3009	1655
Ric1	-3551	-4586
Rin1	5924	6387
Rin2	5382	5273
Rinl	-1964	-1901
Rint1	-2096	-4150
Rps27a	-1504	-1029
Sar1b	-6848	-7206
Sbf1	1902	1414
Sbf2	-2928	-5674
Scarb2	5526	-5142
Scfd1	2215	832
Scoc	-3939	-5162
Sec13	1575	39
Sec16a	572	-4601
Sec16b	7226	6671
Sec22a	-1779	-5709
Sec22b	5609	3487
Sec22c	4146	194
Sec23a	4506	-802
Sec23ip	4637	-3059
Sec24a	-95	-2344
Sec24b	4189	3729
Sec24d	6468	5064
Sec31a	1581	2182
Serpina1d	-3938	1913
Sfn	2885	2824
Sgip1	-2947	-4051
Sh3d19	7205	6726
Sh3gl1	6183	5598
Sh3kbp1	-6312	-6825
Slc2a4	-7086	-7320
Slc2a8	-3410	-2746
Snap23	-1122	-2646
Snap29	-5199	-6114
Snap91	7297	6913
Snapin	1488	-3066
Snf8	2394	-1547
Snx18	2554	-610
Snx2	1444	-3253
Snx5	-38	-4597
Snx9	6264	3205
Sort1	-4502	-4274
Spta1	-2545	-5699
Sptan1	-525	5294
Sptb	-1715	1502
Sptbn1	-4084	-4692
Sptbn2	-1231	1110
Sptbn5	3367	6778
Src	7196	6795
Stam	1544	-52
Stam2	5387	2587
Ston1	5676	5587
Ston2	-2166	-6372
Stx16	4933	-115
Stx17	759	-2924
Stx18	3628	-452
Stx4a	-2746	3133
Stx5a	4418	3544
Stx6	4375	3057
Stxbp3	6198	5478
Surf4	4872	-1590
Synj1	2943	-3070
Synj2	996	-2290
Syt11	7329	6053
Syt2	1155	4285
Tbc1d1	-4111	-3779
Tbc1d10a	1457	3940
Tbc1d10b	2863	3546
Tbc1d10c	-5626	-6381
Tbc1d13	-2783	-1773
Tbc1d14	5413	-1808
Tbc1d15	3197	3994
Tbc1d16	-7094	-7540
Tbc1d17	1557	1992
Tbc1d2	1343	-2664
Tbc1d20	3878	3019
Tbc1d24	-6222	-7802
Tbc1d25	-1935	1976
Tbc1d4	-5806	-7299
Tbc1d7	-4760	-4536
Tbc1d8b	5554	3431
Tfg	-1929	-4911
Tfrc	1928	4292
Tgfa	6309	4116
Tgoln1	-601	-3932
Tjp1	-3710	-5609
Tmed10	5429	480
Tmed2	4476	-272
Tmed3	6576	6027
Tmed7	-747	-6167
Tmed9	3775	-3777
Tmem115	-2170	-121
Tmf1	5476	2253
Tor1a	2581	-142
Tor1b	-2432	-3454
Tpd52	7337	6711
Tpd52l1	-6183	-7224
Trappc1	-3692	-2484
Trappc10	-5862	-6859
Trappc11	-578	-55
Trappc12	1783	2336
Trappc13	-633	-5270
Trappc2l	-5623	-3826
Trappc3	-2835	-4059
Trappc4	-2363	396
Trappc5	-2308	-3230
Trappc6a	3326	-3504
Trappc6b	1361	1137
Trappc8	-2221	-5377
Trappc9	-4762	-5251
Trf	5836	4229
Trip10	-6149	-6123
Trip11	-2178	-3383
Tsc1	-4853	-4582
Tsc2	-3865	-6161
Tsg101	-1470	-2662
Txndc5	7198	5780
Ubap1	28	767
Ubb	5763	-1908
Ubc	-1436	-1699
Ubqln1	-3279	-5104
Ubqln2	4500	1980
Ulk1	-5031	-5929
Use1	3639	2259
Uso1	6091	4331
Usp6nl	5969	5710
Vamp2	-3875	-96
Vamp3	1340	209
Vamp4	4015	3390
Vamp8	-487	2756
Vps25	1921	-2808
Vps28	-262	-2609
Vps36	-1041	-4966
Vps37a	-1385	-3737
Vps37b	5108	4515
Vps37c	6840	4593
Vps37d	4303	2352
Vps45	3111	3511
Vps4a	-6836	-7286
Vps4b	4244	959
Vps51	3780	1101
Vps52	-4155	-3552
Vps53	2432	1700
Vps54	-2623	3076
Vta1	547	-286
Vti1a	2869	-1116
Wasl	2624	5412
Wnt5a	-2222	-4294
Yipf6	-1662	-2231
Ykt6	4836	-818
Ywhab	1382	-1493
Ywhae	-5312	-6195
Ywhag	-2287	-1315
Ywhah	5584	3890
Ywhaq	2145	2532
Ywhaz	5524	2659
Zw10	4767	6235

---

---

Post-translational-protein-phosphorylation

Post-translational-protein-phosphorylation

metric	value
setSize	77
pMANOVA	2.65e-08
p.adjustMANOVA	7.88e-07
s.dist	0.518
s.young	0.385
s.old	0.348
p.young	5.49e-09
p.old	1.34e-07

Top 20 genes

Gene	young	old
Fstl3	7499	6931
Qsox1	7490	6703
Sdc2	7435	6631
Mxra8	7331	6704
Itih2	7098	6851
Igfbp7	7321	6623
Timp1	7129	6798
Fstl1	7372	6531
Vcan	7188	6694
Fn1	7320	6491
Fam20c	7283	6382
Fam20a	6769	6705
Cp	6527	6899
Ckap4	7111	6291
C4b	6877	6457
Bmp4	6772	6517
Lamc1	7347	5936
Fbn1	6968	6107
App	6494	6345
Vwa1	6270	5237

Click HERE to show all gene set members

All member genes

	young	old
Adam10	5268	3108
Ahsg	4752	6702
Alb	-2631	1215
Ano8	-4679	-4635
Aplp2	1887	-5547
Apoa1	-3117	-370
Apoa2	-4104	-1788
Apob	-2312	1254
Apoe	948	-334
App	6494	6345
Bmp4	6772	6517
C3	-1415	-6719
C4b	6877	6457
Calu	6531	4815
Cdh2	5636	2941
Chrdl1	742	2722
Ckap4	7111	6291
Cp	6527	6899
Csf1	-242	4128
Cst3	5893	5471
Dnajc3	-3010	-2409
Eva1a	-3372	-3104
Fam20a	6769	6705
Fam20c	7283	6382
Fbn1	6968	6107
Fga	-3043	855
Fn1	7320	6491
Fstl1	7372	6531
Fstl3	7499	6931
Fuca2	-5682	-4877
Gas6	2658	4026
Golm1	4890	-2511
Gpc3	2127	-5769
Hrc	-7166	-7731
Hsp90b1	-5033	-5785
Igfbp3	-4647	-837
Igfbp4	6397	-513
Igfbp5	4815	2528
Igfbp7	7321	6623
Itih2	7098	6851
Ktn1	3908	-169
Lamb1	6771	-983
Lamb2	2375	4485
Lamc1	7347	5936
Lgals1	7095	3320
Ltbp1	2153	4810
Mbtps1	5821	5093
Men1	-3828	-2806
Mfge8	5789	4710
Mgat4a	2446	753
Mia3	5790	3806
Msln	2360	-3630
Mxra8	7331	6704
Nucb1	5146	-1685
P4hb	6441	4378
Pdia6	-3081	-4513
Penk	-5937	-6873
Pnpla2	-6697	-6659
Prkcsh	2629	2190
Prss23	4876	2314
Qsox1	7490	6703
Scg3	6324	4487
Sdc2	7435	6631
Serpina1d	-3938	1913
Serpinc1	-2974	1289
Shisa5	3383	5045
Sparcl1	5012	6004
Spp1	4125	6580
Stc2	3421	3269
Tgoln1	-601	-3932
Timp1	7129	6798
Tmem132a	6428	5094
Tnc	4757	6330
Trf	5836	4229
Vcan	7188	6694
Vwa1	6270	5237
Wfs1	6267	3063

---

---

Mitochondrial-tRNA-aminoacylation

Mitochondrial-tRNA-aminoacylation

metric	value
setSize	19
pMANOVA	3.66e-08
p.adjustMANOVA	1.06e-06
s.dist	1.04
s.young	-0.756
s.old	-0.712
p.young	1.14e-08
p.old	7.59e-08

Top 20 genes

Gene	young	old
Fars2	-6885	-7333
Sars2	-6953	-6965
Nars2	-6694	-7073
Ppa2	-6676	-6918
Vars2	-6968	-6459
Cars2	-6673	-6550
Yars2	-6001	-7155
Iars2	-5691	-7099
Aars2	-6224	-6392
Hars2	-5875	-6761
Dars2	-5581	-7062
Tars2	-6442	-5956
Mars2	-5106	-7011
Rars2	-5676	-5759
Wars2	-4658	-5948
Pars2	-3576	-3342
Ears2	-1578	-3330
Lars2	-6814	-414
Kars	-1031	-313

Click HERE to show all gene set members

All member genes

	young	old
Aars2	-6224	-6392
Cars2	-6673	-6550
Dars2	-5581	-7062
Ears2	-1578	-3330
Fars2	-6885	-7333
Hars2	-5875	-6761
Iars2	-5691	-7099
Kars	-1031	-313
Lars2	-6814	-414
Mars2	-5106	-7011
Nars2	-6694	-7073
Pars2	-3576	-3342
Ppa2	-6676	-6918
Rars2	-5676	-5759
Sars2	-6953	-6965
Tars2	-6442	-5956
Vars2	-6968	-6459
Wars2	-4658	-5948
Yars2	-6001	-7155

---

---

Transcriptional-activation-of-mitochondrial-biogenesis

Transcriptional-activation-of-mitochondrial-biogenesis

metric	value
setSize	51
pMANOVA	3.86e-08
p.adjustMANOVA	1.1e-06
s.dist	0.628
s.young	-0.418
s.old	-0.468
p.young	2.43e-07
p.old	7.23e-09

Top 20 genes

Gene	young	old
Sod2	-7345	-7817
Atp5b	-7224	-7258
Cycs	-7133	-7302
Idh2	-6961	-7381
Sirt5	-6878	-7374
Ppara	-6545	-7563
Glud1	-6306	-7705
Perm1	-7027	-6909
Ppargc1a	-6363	-7511
Tfb2m	-6600	-7199
Alas1	-6613	-7012
Sirt3	-6560	-6988
Tfam	-6212	-6843
Rxra	-6194	-6804
Hdac3	-6017	-6749
Polrmt	-6292	-5820
Esrra	-6804	-5371
Sirt4	-5710	-5696
Ncor1	-4730	-6152
Ncoa1	-4484	-6419

Click HERE to show all gene set members

All member genes

	young	old
Acss2	-2290	-928
Alas1	-6613	-7012
Atf2	-651	-5338
Atp5b	-7224	-7258
Calm1	-4595	-4970
Carm1	-1701	-5594
Chd9	6475	5594
Creb1	-3517	-2558
Crebbp	-3332	-3533
Crtc1	4822	3316
Crtc2	2460	2533
Crtc3	3593	2639
Cycs	-7133	-7302
Esrra	-6804	-5371
Gabpa	-3716	-6288
Gabpb1	856	-2177
Glud1	-6306	-7705
Hcfc1	-2259	-3907
Hdac3	-6017	-6749
Helz2	-4511	2213
Idh2	-6961	-7381
Med1	-2830	-5832
Mef2c	4484	1893
Mef2d	-4176	-241
Mterf1a	3165	-425
Ncoa1	-4484	-6419
Ncoa2	-3912	-6801
Ncoa6	-1555	-3479
Ncor1	-4730	-6152
Nr1d1	1296	-175
Nrf1	2046	1078
Perm1	-7027	-6909
Polg2	-3186	-2974
Polrmt	-6292	-5820
Ppara	-6545	-7563
Ppargc1a	-6363	-7511
Ppargc1b	-5894	-3355
Pprc1	3621	3813
Rxra	-6194	-6804
Sirt3	-6560	-6988
Sirt4	-5710	-5696
Sirt5	-6878	-7374
Smarcd3	-4349	-759
Sod2	-7345	-7817
Ssbp1	-4608	-3399
Tbl1x	3008	-5102
Tbl1xr1	4225	-2715
Tfam	-6212	-6843
Tfb1m	-3569	-5783
Tfb2m	-6600	-7199
Tgs1	-4991	-5508

---

---

tRNA-Aminoacylation

tRNA-Aminoacylation

metric	value
setSize	26
pMANOVA	4.87e-08
p.adjustMANOVA	1.35e-06
s.dist	0.87
s.young	-0.652
s.old	-0.576
p.young	8.49e-09
p.old	3.7e-07

Top 20 genes

Gene	young	old
Fars2	-6885	-7333
Sars2	-6953	-6965
Nars2	-6694	-7073
Ppa2	-6676	-6918
Vars2	-6968	-6459
Cars2	-6673	-6550
Yars2	-6001	-7155
Iars2	-5691	-7099
Aars2	-6224	-6392
Hars2	-5875	-6761
Dars2	-5581	-7062
Tars2	-6442	-5956
Mars2	-5106	-7011
Rars2	-5676	-5759
Farsb	-5407	-5600
Wars2	-4658	-5948
Ppa1	-3881	-5184
Pars2	-3576	-3342
Farsa	-4086	-2900
Aimp1	-2872	-3408

Click HERE to show all gene set members

All member genes

	young	old
Aars2	-6224	-6392
Aimp1	-2872	-3408
Aimp2	-1669	2875
Cars2	-6673	-6550
Dars2	-5581	-7062
Ears2	-1578	-3330
Eef1e1	-4012	130
Fars2	-6885	-7333
Farsa	-4086	-2900
Farsb	-5407	-5600
Hars2	-5875	-6761
Iars2	-5691	-7099
Kars	-1031	-313
Lars2	-6814	-414
Mars2	-5106	-7011
Nars2	-6694	-7073
Pars2	-3576	-3342
Ppa1	-3881	-5184
Ppa2	-6676	-6918
Rars2	-5676	-5759
Sars2	-6953	-6965
Tars	3361	754
Tars2	-6442	-5956
Vars2	-6968	-6459
Wars2	-4658	-5948
Yars2	-6001	-7155

---

---

Pyruvate-metabolism

Pyruvate-metabolism

metric	value
setSize	27
pMANOVA	5.41e-08
p.adjustMANOVA	1.47e-06
s.dist	0.853
s.young	-0.567
s.old	-0.637
p.young	3.4e-07
p.old	9.95e-09

Top 20 genes

Gene	young	old
Ldhb	-7348	-7811
Mpc2	-7294	-7670
Dld	-7216	-7696
Pdhx	-7172	-7679
Pdhb	-7169	-7319
Pdha1	-7106	-7283
Dlat	-7003	-7332
Vdac1	-7008	-7195
Mpc1	-7043	-7036
Pdk2	-6889	-7055
Bsg	-6548	-7267
Me1	-6765	-6942
Pdpr	-5996	-7506
Pdp2	-5917	-7570
Rxra	-6194	-6804
Gstz1	-6066	-6846
Glo1	-5689	-5454
Ppard	-5588	-4490
Slc16a1	-5936	-4200
Pdp1	-4181	-5275

Click HERE to show all gene set members

All member genes

	young	old
Bsg	-6548	-7267
Dlat	-7003	-7332
Dld	-7216	-7696
Glo1	-5689	-5454
Gstz1	-6066	-6846
Hagh	3129	-1329
Ldha	3559	-4312
Ldhb	-7348	-7811
Me1	-6765	-6942
Mpc1	-7043	-7036
Mpc2	-7294	-7670
Pdha1	-7106	-7283
Pdhb	-7169	-7319
Pdhx	-7172	-7679
Pdk1	4156	-6364
Pdk2	-6889	-7055
Pdk3	6805	6440
Pdk4	-1655	1645
Pdp1	-4181	-5275
Pdp2	-5917	-7570
Pdpr	-5996	-7506
Ppard	-5588	-4490
Rxra	-6194	-6804
Slc16a1	-5936	-4200
Slc16a3	7305	6044
Slc16a8	-4482	-3791
Vdac1	-7008	-7195

---

---

Vesicle-mediated-transport

Vesicle-mediated-transport

metric	value
setSize	560
pMANOVA	1.04e-07
p.adjustMANOVA	2.77e-06
s.dist	0.102
s.young	0.0998
s.old	0.0224
p.young	5.99e-05
p.old	0.368

Top 20 genes

Gene	young	old
Masp1	7449	6981
Rab27b	7417	6961
Ssc5d	7462	6886
Kif1a	7352	6987
Hbegf	7493	6774
Colec12	7398	6846
Snap91	7297	6913
Pla2g4a	7342	6860
Dnm1	7467	6740
Col1a2	7362	6786
Tpd52	7337	6711
Golim4	7319	6690
Src	7196	6795
Rab31	7227	6762
Sh3d19	7205	6726
Sec16b	7226	6671
Col1a1	7237	6629
Arfgap3	7053	6800
Lrp1	7439	6377
Cttn	7225	6511

Click HERE to show all gene set members

All member genes

	young	old
Aak1	-4106	-4972
Acbd3	2132	3045
Actr10	-4042	-3915
Actr1a	3141	466
Actr2	3943	842
Actr3	6464	4364
Adrb2	-1509	-2331
Agfg1	4755	5536
Agpat3	-6640	-7071
Akt1	-6210	-5765
Akt2	-7113	-6780
Akt3	2614	4706
Alb	-2631	1215
Als2	-3840	-4691
Als2cl	-5966	-3827
Amph	-169	-3023
Ank1	-6868	-6830
Ank2	-6606	-7276
Ank3	-2630	2172
Ankrd27	6124	3553
Ankrd28	6460	6474
Ap1b1	-5995	-6810
Ap1g1	-2167	-2801
Ap1g2	2734	5025
Ap1m1	-2470	-5561
Ap1s1	5440	3557
Ap1s2	5488	5457
Ap1s3	408	2693
Ap2a1	4766	-1188
Ap2a2	1207	-4356
Ap2b1	5061	4756
Ap2m1	1964	309
Ap2s1	1934	322
Ap3b1	5445	4096
Ap3s1	6518	3518
Ap4e1	1365	1166
Ap4m1	4271	633
Ap4s1	-6579	-4813
Apoa1	-3117	-370
Apob	-2312	1254
Apoe	948	-334
App	6494	6345
Arcn1	3459	-98
Arf1	-59	-3518
Arf3	6868	5063
Arf4	5304	4250
Arf5	2968	-1634
Arf6	5964	4802
Arfgap1	1944	3018
Arfgap2	-4318	-3966
Arfgap3	7053	6800
Arfip2	787	2716
Arfrp1	-5846	-5542
Arl1	4219	-3201
Arpc1a	1275	-1289
Arpc2	6342	4176
Arpc3	4578	4114
Arpc4	5956	2991
Arpc5	5253	3164
Arrb1	6454	5029
Arrb2	2854	2025
Aspscr1	6566	4592
Bet1l	5334	4588
Bicd1	5360	4677
Bicd2	2300	4029
Bin1	2868	6818
Bloc1s1	-6740	-5818
Bloc1s3	4161	159
Bloc1s4	343	-642
Bloc1s6	4193	3922
Bnip1	-4721	-5553
Btc	3998	3938
C2cd5	-1615	241
Calm1	-4595	-4970
Calr	-3747	-4997
Capza2	-2146	-4566
Capzb	-5179	-686
Cbl	2363	821
Ccz1	6818	1385
Cd163	-5224	-5716
Cd36	-5986	-7614
Cd3d	-417	-312
Cd4	-2571	-2169
Cd59b	-5550	-3313
Cenpe	6429	5244
Chm	4576	910
Chml	4934	6307
Chmp2a	1793	-1096
Chmp2b	1232	-1104
Chmp3	6948	5512
Chmp4b	5717	1200
Chmp4c	6803	4718
Chmp5	3696	136
Chmp6	1760	-423
Chmp7	3831	4757
Chrm2	-3866	-3729
Clint1	5780	908
Clta	2287	-631
Cltb	6447	5854
Cltc	2485	6
Cnih1	-1321	-2923
Cnih2	383	-104
Cog1	3791	2760
Cog2	2381	-2488
Cog3	1640	-3468
Cog4	-3964	-4303
Cog5	-5907	-6472
Cog6	-3930	-6209
Cog7	-2722	-4763
Cog8	-6900	-7344
Col1a1	7237	6629
Col1a2	7362	6786
Col3a1	6563	6455
Col4a1	5635	5181
Col4a2	5963	4644
Colec11	-3065	-6574
Colec12	7398	6846
Copa	3741	-629
Copb1	5660	3885
Copb2	3538	-3332
Cope	-4431	-3559
Copg1	5827	4453
Copg2	968	-3951
Cops2	3345	-2086
Cops3	-4305	-5384
Cops4	-3918	-1816
Cops5	-4403	-5437
Cops6	-5787	-5427
Cops7a	-2517	-2882
Cops7b	-537	-291
Cops8	-5408	-5033
Copz1	1326	-1220
Copz2	7011	4766
Cpd	6006	6688
Csnk1d	5455	4161
Ctsc	-3996	-6450
Ctsz	6955	6572
Cttn	7225	6511
Cux1	6746	4816
Cyth1	-5817	-6706
Cyth2	5383	2969
Cyth3	7000	6420
Cyth4	536	-1578
Dab2	5377	3411
Dctn1	-5873	-3219
Dctn2	-500	-3034
Dctn3	-591	-407
Dctn4	-5115	-6149
Dctn5	2992	-89
Dctn6	-5983	-6121
Dennd1a	-3834	-5238
Dennd1b	-1530	1678
Dennd1c	-3480	-2470
Dennd2a	6844	5576
Dennd2c	-4692	-3256
Dennd2d	4093	2364
Dennd3	-6241	-3522
Dennd4a	5637	6344
Dennd4b	-6467	-5983
Dennd4c	-3905	-7170
Dennd5a	4356	4873
Dennd5b	-4417	-4117
Dennd6a	-877	-1347
Dennd6b	-5378	-2351
Dnase2a	5652	6289
Dnm1	7467	6740
Dnm2	-4130	324
Dnm3	-1732	3166
Dtnbp1	-6883	-7158
Dvl2	5014	-1883
Dync1h1	2619	4531
Dync1i2	5203	4439
Dync1li1	6485	5683
Dync1li2	4461	5015
Dynll1	5075	5782
Dynll2	-6128	-5510
Egf	-5607	-6796
Egfr	6827	4231
Epn1	-6564	-4868
Epn2	-3152	-3544
Eps15	4596	4742
Eps15l1	-5775	-6626
Ereg	7082	6195
Exoc1	5938	5433
Exoc2	2456	-1179
Exoc3	-5576	-5746
Exoc4	5248	5325
Exoc5	5055	3118
Exoc6	-5248	-6974
Exoc7	-3011	-2611
Exoc8	-4733	-4562
F8	-1506	592
Fcho2	-3325	-1824
Fnbp1	280	-2209
Fnbp1l	-6107	-6940
Fth1	-6984	-6689
Fzd4	-3807	-5670
Gabarap	3004	762
Gabarapl2	-1459	-1609
Gak	905	1705
Galnt1	-866	-4743
Galnt2	5385	1538
Gapvd1	-3983	-4411
Gbf1	-2279	-1916
Gcc1	4373	2954
Gcc2	4838	-874
Gdi1	-1923	2493
Gdi2	5610	3130
Gga1	-3748	-2504
Gga2	3490	5354
Gga3	-4565	-2465
Gja3	-5960	-6756
Gja4	4489	938
Gja5	2759	713
Gjc1	2184	5758
Gjc2	6702	4801
Gm11808	-5706	-216
Gns	-4478	-5630
Golga1	-1251	-80
Golga4	7136	5783
Golga5	4364	2357
Golgb1	6598	6059
Golim4	7319	6690
Gorasp1	273	-4434
Gosr1	-1133	-2009
Gosr2	6073	-777
Gps1	2514	-690
Grb2	-4590	-3819
Grk2	-5236	-5006
Grk3	2707	2012
Hba-a1	-5686	-3320
Hbegf	7493	6774
Hgs	4975	3859
Hip1	5040	6331
Hip1r	-1687	669
Hp	-4101	-4476
Hps1	5310	4973
Hps4	-450	-1520
Hpx	-3289	1603
Hsp90b1	-5033	-5785
Hspa8	-5126	-2542
Hsph1	-1878	2861
Hyou1	-3679	-4198
Igf2r	6292	-878
Igkc	-2112	1503
Itsn1	946	-1939
Itsn2	-3761	822
Kdelr1	3997	-4196
Kdelr2	5459	4436
Kdelr3	6958	6182
Kif11	5443	6537
Kif13b	750	3676
Kif15	2773	3536
Kif16b	-6047	-7444
Kif18a	5407	4955
Kif18b	3922	4124
Kif1a	7352	6987
Kif1b	-574	-2411
Kif1c	2439	-1206
Kif20a	3354	4533
Kif20b	5876	4188
Kif21a	-3345	-4447
Kif21b	3282	3606
Kif22	2609	3724
Kif23	4557	937
Kif26a	-3618	-6227
Kif26b	6048	6045
Kif2a	6321	-1561
Kif2c	5287	3465
Kif3a	4134	6220
Kif3b	6559	6252
Kif3c	5698	6444
Kif4	4235	4781
Kif5a	504	2105
Kif5b	6829	6240
Kif5c	6816	6381
Kif6	-5370	-6905
Kifap3	4639	-898
Kifc1	4168	3274
Kifc2	-3681	-4577
Klc1	5054	5911
Klc2	-5210	-4500
Klc4	774	-2078
Ldlr	4127	4914
Ldlrap1	-211	-1969
Lman1	-1130	-5060
Lman1l	5574	5946
Lman2	-2352	-4702
Lman2l	-4616	-4849
Lnpep	2021	4145
Lrp1	7439	6377
M6pr	3239	-1497
Madd	-5791	-4960
Man1a	664	-2507
Man1a2	5867	5756
Man1c1	5900	2279
Man2a1	2682	1662
Man2a2	3550	-4096
Map1lc3b	-6279	-7247
Masp1	7449	6981
Mcfd2	2584	-5058
Mia2	-5629	-7819
Mia3	5790	3806
Mon1a	-2647	1251
Mon1b	1785	1177
Msr1	2574	-850
Mvb12a	-4581	-3590
Mvb12b	2144	-1272
Myh9	4478	4696
Myo1c	3674	3464
Myo5a	6359	5343
Myo6	-2507	-921
Naa30	-2423	-4364
Naa35	2035	5767
Naa38	-5675	-5456
Napa	-5159	-4315
Napb	1860	6167
Napg	2133	3081
Nbas	-1485	-6584
Necap1	1847	-1243
Necap2	4265	3227
Nedd8	95	641
Nsf	-957	-3637
Ocrl	782	-3741
Optn	-6274	-7401
Pacsin2	-6962	-7292
Pacsin3	5300	2609
Pafah1b1	-3476	-5904
Pafah1b2	5668	4043
Pafah1b3	5755	2487
Picalm	-2717	3439
Pik3c2a	-3001	-2146
Pip5k1c	3011	4725
Pla2g4a	7342	6860
Pla2g6	-1374	-1982
Plin3	-6858	-7441
Polg	-5193	-4833
Ppp6c	-3624	-5684
Ppp6r1	-5185	-4073
Ppp6r3	-5054	-6661
Preb	-5765	-4262
Prkaa2	-6100	-7414
Prkab1	-4034	-7255
Prkab2	7420	5930
Prkag1	-6213	-4030
Prkag2	4029	-2192
Prkag3	5303	4957
Pum1	-1396	-1790
Rab10	-4439	-5212
Rab11a	-2501	-5885
Rab11b	1212	-3386
Rab12	-5280	-6895
Rab13	6900	6349
Rab14	-5276	-6634
Rab18	-1250	-4021
Rab1a	-3223	-6062
Rab1b	-6030	-5486
Rab21	-4812	-6186
Rab27a	-1179	-3721
Rab27b	7417	6961
Rab30	-3630	-2354
Rab31	7227	6762
Rab33b	6021	3134
Rab35	5336	845
Rab36	4621	4563
Rab3a	-6304	-4824
Rab3gap1	4350	3177
Rab3gap2	6715	6249
Rab3il1	6333	4912
Rab3ip	-6514	-7168
Rab43	4039	2459
Rab4a	1717	2240
Rab5a	5098	86
Rab5b	-1911	-4750
Rab5c	3142	-1160
Rab6a	6083	2806
Rab6b	4327	1836
Rab7	-5369	-6377
Rab7b	6565	5190
Rab8a	1372	1357
Rab8b	4850	2440
Rab9	-2739	-6338
Rabep1	2875	5000
Rabepk	-2337	-3341
Rabgap1	2612	817
Rabgef1	-85	-2941
Rac1	328	-2928
Racgap1	4251	3966
Rala	-696	-1429
Ralgapa2	-6880	-7729
Ralgapb	-4179	-6708
Reps1	1577	-1085
Reps2	1370	-3943
Rgp1	-2686	-1308
Rhobtb3	5831	-4485
Rhoq	-3009	1655
Ric1	-3551	-4586
Rin1	5924	6387
Rin2	5382	5273
Rinl	-1964	-1901
Rint1	-2096	-4150
Rps27a	-1504	-1029
Sar1b	-6848	-7206
Sbf1	1902	1414
Sbf2	-2928	-5674
Scara5	-7171	-7514
Scarb1	-5798	-5138
Scarb2	5526	-5142
Scarf1	-5304	-4560
Scfd1	2215	832
Scoc	-3939	-5162
Sec13	1575	39
Sec16a	572	-4601
Sec16b	7226	6671
Sec22a	-1779	-5709
Sec22b	5609	3487
Sec22c	4146	194
Sec23a	4506	-802
Sec23ip	4637	-3059
Sec24a	-95	-2344
Sec24b	4189	3729
Sec24d	6468	5064
Sec31a	1581	2182
Serpina1d	-3938	1913
Sfn	2885	2824
Sgip1	-2947	-4051
Sh3d19	7205	6726
Sh3gl1	6183	5598
Sh3kbp1	-6312	-6825
Slc2a4	-7086	-7320
Slc2a8	-3410	-2746
Snap23	-1122	-2646
Snap29	-5199	-6114
Snap91	7297	6913
Snapin	1488	-3066
Snf8	2394	-1547
Snx18	2554	-610
Snx2	1444	-3253
Snx5	-38	-4597
Snx9	6264	3205
Sort1	-4502	-4274
Sparc	6776	6134
Spta1	-2545	-5699
Sptan1	-525	5294
Sptb	-1715	1502
Sptbn1	-4084	-4692
Sptbn2	-1231	1110
Sptbn5	3367	6778
Src	7196	6795
Ssc5d	7462	6886
Stab1	3960	457
Stab2	229	2485
Stam	1544	-52
Stam2	5387	2587
Ston1	5676	5587
Ston2	-2166	-6372
Stx16	4933	-115
Stx17	759	-2924
Stx18	3628	-452
Stx4a	-2746	3133
Stx5a	4418	3544
Stx6	4375	3057
Stxbp3	6198	5478
Surf4	4872	-1590
Synj1	2943	-3070
Synj2	996	-2290
Syt11	7329	6053
Syt2	1155	4285
Tbc1d1	-4111	-3779
Tbc1d10a	1457	3940
Tbc1d10b	2863	3546
Tbc1d10c	-5626	-6381
Tbc1d13	-2783	-1773
Tbc1d14	5413	-1808
Tbc1d15	3197	3994
Tbc1d16	-7094	-7540
Tbc1d17	1557	1992
Tbc1d2	1343	-2664
Tbc1d20	3878	3019
Tbc1d24	-6222	-7802
Tbc1d25	-1935	1976
Tbc1d4	-5806	-7299
Tbc1d7	-4760	-4536
Tbc1d8b	5554	3431
Tfg	-1929	-4911
Tfrc	1928	4292
Tgfa	6309	4116
Tgoln1	-601	-3932
Tjp1	-3710	-5609
Tmed10	5429	480
Tmed2	4476	-272
Tmed3	6576	6027
Tmed7	-747	-6167
Tmed9	3775	-3777
Tmem115	-2170	-121
Tmf1	5476	2253
Tor1a	2581	-142
Tor1b	-2432	-3454
Tpd52	7337	6711
Tpd52l1	-6183	-7224
Trappc1	-3692	-2484
Trappc10	-5862	-6859
Trappc11	-578	-55
Trappc12	1783	2336
Trappc13	-633	-5270
Trappc2l	-5623	-3826
Trappc3	-2835	-4059
Trappc4	-2363	396
Trappc5	-2308	-3230
Trappc6a	3326	-3504
Trappc6b	1361	1137
Trappc8	-2221	-5377
Trappc9	-4762	-5251
Trf	5836	4229
Trip10	-6149	-6123
Trip11	-2178	-3383
Tsc1	-4853	-4582
Tsc2	-3865	-6161
Tsg101	-1470	-2662
Txndc5	7198	5780
Ubap1	28	767
Ubb	5763	-1908
Ubc	-1436	-1699
Ubqln1	-3279	-5104
Ubqln2	4500	1980
Ulk1	-5031	-5929
Use1	3639	2259
Uso1	6091	4331
Usp6nl	5969	5710
Vamp2	-3875	-96
Vamp3	1340	209
Vamp4	4015	3390
Vamp8	-487	2756
Vps25	1921	-2808
Vps28	-262	-2609
Vps36	-1041	-4966
Vps37a	-1385	-3737
Vps37b	5108	4515
Vps37c	6840	4593
Vps37d	4303	2352
Vps45	3111	3511
Vps4a	-6836	-7286
Vps4b	4244	959
Vps51	3780	1101
Vps52	-4155	-3552
Vps53	2432	1700
Vps54	-2623	3076
Vta1	547	-286
Vti1a	2869	-1116
Wasl	2624	5412
Wnt5a	-2222	-4294
Yipf6	-1662	-2231
Ykt6	4836	-818
Ywhab	1382	-1493
Ywhae	-5312	-6195
Ywhag	-2287	-1315
Ywhah	5584	3890
Ywhaq	2145	2532
Ywhaz	5524	2659
Zw10	4767	6235

---

---

Metabolism-of-proteins

Metabolism-of-proteins

metric	value
setSize	1577
pMANOVA	1.2e-07
p.adjustMANOVA	3.14e-06
s.dist	0.0624
s.young	-0.0131
s.old	-0.061
p.young	0.393
p.old	7.33e-05

Top 20 genes

Gene	young	old
Rpl3l	-7308	-7793
Mrpl30	-7337	-7761
Ttll1	-7332	-7589
Etfb	-7336	-7558
Hrc	-7166	-7731
Nudt14	-7278	-7587
Mrpl42	-7248	-7608
Crhr2	-7109	-7742
Ptcd3	-7230	-7612
Mrps35	-7210	-7615
Mme	-7081	-7744
Acadvl	-7306	-7500
St6galnac6	-7184	-7584
Mrps17	-7178	-7576
Msrb2	-7107	-7648
Agtpbp1	-7049	-7685
Mrpl2	-7320	-7372
Mrps9	-6971	-7623
Asb14	-6865	-7706
Csnk2a1	-6837	-7714

Click HERE to show all gene set members

All member genes

	young	old
Aaas	-621	4067
Aars2	-6224	-6392
Abca3	-2208	-1813
Acadvl	-7306	-7500
Ace	7390	6602
Ace2	1539	2949
Ache	2008	-1040
Actb	662	-310
Actl6a	313	-4626
Actr10	-4042	-3915
Actr1a	3141	466
Actr5	-3219	-877
Actr8	-4311	-3756
Adam10	5268	3108
Adamts1	4892	1782
Adamts10	7274	6383
Adamts12	6356	2284
Adamts14	3117	5979
Adamts15	-6097	-4869
Adamts17	4816	29
Adamts19	7386	6991
Adamts2	7469	6535
Adamts20	7284	6952
Adamts3	-4916	-4222
Adamts4	4717	-509
Adamts5	3233	-4965
Adamts6	3231	5932
Adamts7	-6542	-7750
Adamts8	6496	5738
Adamts9	-4316	-4299
Adamtsl1	1043	5882
Adamtsl2	7259	6477
Adamtsl3	1162	2085
Adamtsl4	-969	5236
Adamtsl5	7266	5725
Add1	4420	1516
Adgrf5	-6023	-7340
Adora2a	-2137	-6664
Adra2c	-1945	2287
Adrb2	-1509	-2331
Agbl2	-4989	-4885
Agbl3	-315	3816
Agbl5	904	-2279
Agt	-4320	-6233
Agtpbp1	-7049	-7685
Ahsg	4752	6702
Aimp1	-2872	-3408
Aimp2	-1669	2875
Alb	-2631	1215
Alg1	6726	5694
Alg10b	-4303	-7294
Alg11	-1229	-3115
Alg12	-2699	-3881
Alg14	474	3160
Alg2	-518	-1267
Alg3	-322	-2230
Alg5	5916	5071
Alg6	-1841	-4848
Alg8	1524	339
Alg9	-2204	-6400
Alpl	-5617	3337
Amdhd2	4916	2058
Amfr	5931	4520
Ank1	-6868	-6830
Ank2	-6606	-7276
Ank3	-2630	2172
Ankrd28	6460	6474
Ankrd9	-7090	-6720
Ano8	-4679	-4635
Anpep	3442	4875
Aopep	6791	6945
Ap3m1	-4958	-5596
Apc	6673	5921
Apeh	-5071	-1990
Aph1a	-4147	-4136
Aph1b	-1630	-4351
Aplp2	1887	-5547
Apoa1	-3117	-370
Apoa2	-4104	-1788
Apob	-2312	1254
Apoe	948	-334
App	6494	6345
Ar	594	2654
Arcn1	3459	-98
Arf1	-59	-3518
Arf3	6868	5063
Arf4	5304	4250
Arf5	2968	-1634
Arfgap1	1944	3018
Arfgap2	-4318	-3966
Arfgap3	7053	6800
Arfgef2	-5895	-6838
Arl2	-2599	-3886
Arrb1	6454	5029
Arrb2	2854	2025
Arsa	3605	-897
Arsb	6684	5613
Arsg	5743	5658
Arsi	-5136	-5584
Arsj	-449	-2677
Arsk	5442	4251
Art3	-6164	-5728
Art4	-2568	-7417
Asb1	-102	1952
Asb10	-7144	-7334
Asb11	-6586	-6052
Asb12	-2799	-3044
Asb13	-3878	-3632
Asb14	-6865	-7706
Asb15	-6353	-7305
Asb18	3583	299
Asb2	-6602	-6474
Asb3	923	1694
Asb4	-4682	-6923
Asb5	-5465	3138
Asb6	4507	3595
Asb7	1837	-1502
Asb8	-6584	-6597
Asns	4991	912
Asxl1	403	-4672
Asxl2	853	-1232
Atf3	7376	6801
Atf4	6340	6447
Atf6	-476	-5587
Atp6ap2	5191	6005
Atp6v0d1	307	-2150
Atxn3	1750	2527
Atxn7	-5119	-340
Aurka	4746	4318
Aurkaip1	-6248	-5678
Aurkb	3210	3991
Axin1	3573	2919
Axin2	5432	6015
B2m	4326	4857
B3galnt2	-883	-1479
B3glct	4987	1600
B3gnt2	6711	5903
B3gnt3	-5788	-6546
B3gnt5	4473	902
B3gnt8	3406	3537
B3gnt9	7252	6495
B3gntl1	2489	2271
B4galt1	3267	1068
B4galt2	6315	4664
B4galt3	-4310	-1405
B4galt4	-4249	-652
B4galt5	6407	5561
B4galt6	6036	6103
Babam1	-5658	-6156
Bace1	-2996	-2188
Bap1	-3398	-4129
Bard1	676	4014
Bche	5266	6487
Bcl10	3503	933
Bet1l	5334	4588
Birc2	-3354	-4484
Birc3	5640	1352
Birc5	2583	4194
Blm	3161	4080
Bmi1	-6397	-6220
Bmp4	6772	6517
Brca1	3122	4948
Bst1	3734	939
Btbd1	-5543	-6166
Btbd6	-4970	-3767
Btrc	-983	-2965
C1galt1	-3822	-3973
C1galt1c1	-850	202
C3	-1415	-6719
C4b	6877	6457
Calm1	-4595	-4970
Calr	-3747	-4997
Calu	6531	4815
Camkmt	-1938	143
Cand1	4666	2474
Canx	-5693	-7105
Capza2	-2146	-4566
Capzb	-5179	-686
Cars2	-6673	-6550
Casp8ap2	2876	19
Cbx2	3715	1391
Cbx4	1789	2079
Cbx5	6152	6171
Cbx8	-714	-3048
Ccdc22	-3911	-3223
Ccdc59	2799	3143
Ccdc8	6911	6003
Ccl2	2195	-4721
Ccna2	5229	5333
Ccne1	3855	1801
Ccne2	898	788
Ccnf	4264	1710
Ccp110	4063	5681
Cct2	792	358
Cct3	-2368	552
Cct4	-2360	-769
Cct5	-2553	-1111
Cct6a	-3030	-1077
Cct7	-2495	-3623
Cct8	4141	3732
Cd109	5967	6483
Cd52	2748	2865
Cd59b	-5550	-3313
Cdc20	1433	3116
Cdc25a	1914	-3410
Cdc34	-7020	-6823
Cdc73	61	-1350
Cdca8	5325	3945
Cdh2	5636	2941
Cdk1	5710	3875
Cebpb	-2936	1517
Cebpg	-1874	157
Cetn2	1003	-308
Cfp	-3940	-4106
Chchd1	-5921	-5916
Chd3	-4325	-6065
Chm	4576	910
Chml	4934	6307
Chrdl1	742	2722
Chst10	4959	4476
Cish	-5557	-3161
Ckap4	7111	6291
Clspn	5575	4859
Cma1	988	82
Cmas	3263	831
Cnih1	-1321	-2923
Cnih2	383	-104
Cntn5	-1588	116
Cog1	3791	2760
Cog2	2381	-2488
Cog3	1640	-3468
Cog4	-3964	-4303
Cog5	-5907	-6472
Cog6	-3930	-6209
Cog7	-2722	-4763
Cog8	-6900	-7344
Commd1	-5943	-4838
Commd10	3518	-1486
Commd2	2188	-1892
Commd3	-6035	-3748
Commd4	4656	3036
Commd5	2011	2382
Commd6	3443	2091
Commd7	5655	3788
Commd8	3451	-3660
Commd9	-1581	-2407
Copa	3741	-629
Copb1	5660	3885
Copb2	3538	-3332
Cope	-4431	-3559
Copg1	5827	4453
Copg2	968	-3951
Cops2	3345	-2086
Cops3	-4305	-5384
Cops4	-3918	-1816
Cops5	-4403	-5437
Cops6	-5787	-5427
Cops7a	-2517	-2882
Cops7b	-537	-291
Cops8	-5408	-5033
Copz1	1326	-1220
Copz2	7011	4766
Cp	6527	6899
Cpa3	2731	-2871
Cpe	7318	6792
Cpm	-2143	-4358
Creb3	6218	5519
Creb3l1	5478	1864
Creb3l2	7311	6712
Crebbp	-3332	-3533
Crebrf	-3424	-2950
Crhr2	-7109	-7742
Csf1	-242	4128
Csf2ra	6263	4780
Csf2rb2	4887	3245
Csnk1d	5455	4161
Csnk2a1	-6837	-7714
Csnk2a2	2827	-156
Csnk2b	-4627	-5569
Cst3	5893	5471
Ctbp1	-4329	-4109
Ctdsp2	5719	4247
Ctnnb1	-2555	-3976
Ctr9	-2675	-4126
Ctsa	3546	448
Ctsc	-3996	-6450
Ctsh	-6085	-6210
Ctsz	6955	6572
Cul1	-3119	-3855
Cul2	-3785	-5613
Cul3	-3349	-6313
Cul4a	-2763	-4918
Cul4b	4129	1613
Cul5	-2055	-6542
Cul7	6730	5502
Cul9	3989	2046
Cxxc1	-2958	-2889
Cyld	7081	5831
Dad1	3002	2211
Dag1	3395	1176
Dap3	-6390	-6628
Dars2	-5581	-7062
Daxx	2951	-218
Dcaf10	3471	3488
Dcaf11	-6221	-5624
Dcaf13	2659	2118
Dcaf17	3630	1868
Dcaf4	-6327	-7129
Dcaf5	4995	1828
Dcaf6	-3473	-5694
Dcaf7	-3124	-4459
Dcaf8	-4109	-2864
Dcp2	-2491	-1861
Dctn1	-5873	-3219
Dctn2	-500	-3034
Dctn3	-591	-407
Dctn4	-5115	-6149
Dctn5	2992	-89
Dctn6	-5983	-6121
Dcun1d2	-6790	-7371
Dcun1d3	3144	6305
Dcun1d4	-3261	-6177
Dcun1d5	-5336	-5719
Dda1	3835	3150
Ddb1	6409	4126
Ddb2	1523	1797
Ddit3	-3741	3818
Ddost	5379	-181
Ddx11	1085	1922
Ddx17	-3701	4081
Ddx5	-4166	-1868
Ddx58	633	5650
Derl1	1222	-3922
Derl2	-2315	-4575
Dhdds	4837	4695
Dhps	296	-2205
Dis3	-3755	1665
Dnajb11	6722	4391
Dnajb9	-1972	-5610
Dnajc24	-199	-1508
Dnajc3	-3010	-2409
Dnmt1	5368	2034
Dnmt3a	3914	1291
Dnmt3b	-112	312
Dohh	-5924	794
Dolk	-5587	-3086
Dolpp1	921	-3874
Dpagt1	-2089	-1947
Dph1	-1032	74
Dph2	-2602	-958
Dph3	-2007	-1548
Dph5	1184	3517
Dph6	640	675
Dph7	2782	2361
Dpm1	-1101	-5227
Dpm2	4502	2233
Dpm3	1522	-4346
Dpp4	757	-4809
Dtl	3180	3151
Dync1h1	2619	4531
Dync1i2	5203	4439
Dync1li1	6485	5683
Dync1li2	4461	5015
Dynll1	5075	5782
Dynll2	-6128	-5510
Ears2	-1578	-3330
Edem1	486	4895
Edem2	4007	4169
Edem3	4895	3637
Eef1a2	-6357	-5633
Eef1b2	637	-2698
Eef1d	-5848	-4473
Eef1e1	-4012	130
Eef1g	-3903	-4521
Eef2	4391	275
Eef2kmt	7443	4232
Eif1a	5914	5726
Eif2ak3	5562	4296
Eif2b1	-2994	-2186
Eif2b2	-1328	-2163
Eif2b3	3073	3436
Eif2b4	-6044	-4703
Eif2b5	-2667	-3106
Eif2s1	-806	-2500
Eif2s2	-2303	-4953
Eif2s3x	-4218	-6299
Eif3a	5490	-66
Eif3b	3099	2631
Eif3c	1453	-4912
Eif3d	3348	2210
Eif3e	3390	-106
Eif3f	-4014	-4796
Eif3g	-2184	-890
Eif3h	5226	367
Eif3i	-297	-2201
Eif3j2	4071	-745
Eif3k	-2704	-1973
Eif3l	-978	-1218
Eif3m	-5876	-5839
Eif4a1	4689	4812
Eif4a2	-1851	-4012
Eif4e	-5795	-5062
Eif4ebp1	-2737	-1088
Eif4g1	-5508	-5906
Eif4h	-1666	-2254
Eif5	3307	4034
Eif5a	-5707	-6681
Eif5a2	6055	5643
Eif5b	-1589	-4589
Eloc	-3360	-5140
Engase	-3058	-2856
Enpep	-2718	-6510
Ep300	-2809	-454
Epas1	-5094	-7186
Eral1	-5904	-6599
Ercc8	-3111	-3755
Ern1	5716	550
Ero1l	3360	2467
Ero1lb	-1877	-1899
Esr1	-3962	1501
Etf1	2542	-2446
Etfb	-7336	-7558
Etfbkmt	-5157	-5512
Eva1a	-3372	-3104
Exoc1	5938	5433
Exoc2	2456	-1179
Exoc3	-5576	-5746
Exoc4	5248	5325
Exoc5	5055	3118
Exoc6	-5248	-6974
Exoc7	-3011	-2611
Exoc8	-4733	-4562
Exosc1	1515	4257
Exosc2	2266	680
Exosc3	385	-306
Exosc4	-4926	-3012
Exosc5	762	-180
Exosc7	-2562	-3338
Exosc8	891	3693
Exosc9	612	225
Extl1	-3156	-5686
Extl2	2081	-1935
Extl3	624	-1487
F8	-1506	592
Fam20a	6769	6705
Fam20c	7283	6382
Fars2	-6885	-7333
Farsa	-4086	-2900
Farsb	-5407	-5600
Fau	519	-1304
Fbn1	6968	6107
Fbxl12	-3162	-3991
Fbxl14	3964	2016
Fbxl15	724	-2552
Fbxl16	5393	3141
Fbxl18	1694	2726
Fbxl19	5218	4077
Fbxl20	1584	3062
Fbxl22	-6927	-5051
Fbxl3	1055	734
Fbxl4	3609	3334
Fbxl5	-4746	-6160
Fbxl7	3843	162
Fbxl8	3805	3262
Fbxo10	1079	-2624
Fbxo11	3100	-4709
Fbxo17	7173	6029
Fbxo21	-5479	-6541
Fbxo22	-3200	-2152
Fbxo30	-78	-1089
Fbxo31	-6155	-5375
Fbxo32	2078	-742
Fbxo4	4605	3758
Fbxo40	5009	6074
Fbxo6	-1511	-1453
Fbxo7	-1223	-4532
Fbxo9	-730	2641
Fbxw11	4422	3035
Fbxw2	-1901	-1579
Fbxw4	-4861	-1810
Fbxw5	-6313	-5977
Fbxw7	-1767	3232
Fbxw8	-1085	-1011
Fbxw9	6522	5511
Fcgr4	4737	5500
Fcsk	1861	-708
Fem1b	1801	-2592
Fem1c	-2700	-2111
Fga	-3043	855
Fkbp14	5213	888
Fkbp8	357	-632
Fkbp9	6838	4083
Fn1	7320	6491
Fn3k	-6365	-7322
Fn3krp	-3906	-5949
Folr2	-5324	-4446
Foxk1	2100	2958
Foxk2	-4420	-3853
Foxo4	-4257	-3546
Fpgt	1415	-71
Fstl1	7372	6531
Fstl3	7499	6931
Fuca1	5465	3412
Fuca2	-5682	-4877
Fuom	-6371	-3820
Furin	1738	-2954
Fut8	5119	-1697
Gadd45gip1	-6867	-6703
Galnt1	-866	-4743
Galnt10	2930	4030
Galnt11	-1695	-4085
Galnt15	-5397	-6655
Galnt16	6303	-4778
Galnt17	5038	-3051
Galnt18	41	-332
Galnt2	5385	1538
Galnt4	6322	3680
Galnt7	6155	6218
Gan	6186	6129
Ganab	3151	-1625
Gapdhs	-2761	375
Gas6	2658	4026
Gata3	-2641	-1970
Gata4	-1370	-4005
Gata6	379	-3225
Gba	6569	5896
Gbf1	-2279	-1916
Gcnt1	6989	6668
Gcnt4	7114	6388
Gfm1	-6643	-7457
Gfm2	-6544	-7469
Gfpt1	4092	919
Gfpt2	-5090	1134
Gga1	-3748	-2504
Gga2	3490	5354
Gga3	-4565	-2465
Ggcx	2522	-2265
Glb1	5822	1047
Gm11808	-5706	-216
Gm28042	-6038	-5882
Gm49336	3826	3163
Gm50388	-923	1381
Gmds	3531	4447
Gmppa	3080	1628
Gmppb	1721	2324
Gnai1	6499	6092
Gnai2	3854	1841
Gnai3	5056	4344
Gnao1	7515	7001
Gnaz	1216	906
Gnb1	3378	553
Gnb2	2426	-280
Gnb3	-4309	-7248
Gnb4	4703	4055
Gnb5	-739	-4170
Gne	1172	-1633
Gng10	3588	3127
Gng11	-2381	-3084
Gng12	2443	-1045
Gng2	2834	1842
Gng8	6555	5926
Gngt2	-3723	-2987
Gnpnat1	4972	1038
Golgb1	6598	6059
Golm1	4890	-2511
Gorasp1	273	-4434
Gosr1	-1133	-2009
Gosr2	6073	-777
Gpaa1	-4670	-1612
Gpc3	2127	-5769
Gpihbp1	-3847	-6453
Gpld1	-2570	-4883
Gps1	2514	-690
Gsk3a	-4423	-3666
Gsn	4065	5762
Gspt1	-2246	-3914
Gspt2	5388	4818
H3f3a	-2808	-2666
Hars2	-5875	-6761
Hcfc1	-2259	-3907
Hdac1	5275	3944
Hdac2	-4789	-5887
Hdac3	-6017	-6749
Hdac4	-3163	-4830
Hdac7	-3802	-822
Hdgf	2255	91
Herc2	-1395	-914
Herpud1	-7032	-7357
Hgs	4975	3859
Hic1	-225	1082
Hif1a	6604	1121
Hif3a	-2849	-3750
Hipk2	6736	4300
Hltf	2357	2874
Hnrnpc	-6475	-7636
Hnrnpk	2447	-3116
Hrc	-7166	-7731
Hsp90b1	-5033	-5785
Hspa5	-6240	-7173
Hspa8	-5126	-2542
Hspg2	6535	3769
Hyou1	-3679	-4198
Iars2	-5691	-7099
Icmt	-1789	-2294
Ide	-4424	-4327
Ifih1	571	5239
Igf1	7240	5920
Igf2	768	-5914
Igfals	-6489	-7076
Igfbp3	-4647	-837
Igfbp4	6397	-513
Igfbp5	4815	2528
Igfbp6	6676	6725
Igfbp7	7321	6623
Ikbke	5570	5841
Ikbkg	-3327	-2281
Il33	5215	4653
Incenp	3287	3181
Ing2	3055	3644
Inha	-2463	-4909
Inhba	7150	6998
Inhbb	4233	-3243
Ino80	6135	6237
Ino80b	3339	2066
Ino80c	6015	6158
Ino80d	-4098	3121
Ino80e	-871	3147
Itih2	7098	6851
Itm2b	-1736	-5722
Josd1	-5198	-5638
Josd2	-5035	-2496
Kars	-1031	-313
Kat2a	-2729	-1556
Kat2b	316	-3888
Kbtbd13	-2046	-5636
Kbtbd7	4438	5031
Kbtbd8	-3915	-3780
Kctd6	1255	4607
Kctd7	3820	3028
Kdelr1	3997	-4196
Kdelr2	5459	4436
Kdelr3	6958	6182
Kdm1b	-2404	-4878
Keap1	-3752	-4257
Khsrp	1152	-2316
Kif13a	1755	4945
Kif5a	504	2105
Kif5b	6829	6240
Kif5c	6816	6381
Kifc3	-6402	-6251
Kin	96	1703
Klf4	-3000	-1524
Klhdc3	-5836	-4704
Klhl11	-3243	925
Klhl13	5400	5955
Klhl2	4174	4470
Klhl20	2851	385
Klhl21	-6424	-6982
Klhl22	7294	1071
Klhl25	201	-728
Klhl3	-4940	-6984
Klhl41	7483	7027
Klhl42	-1108	2867
Klhl5	3349	-4102
Klhl9	-3029	-6196
Ktn1	3908	-169
L3mbtl2	-2369	-3829
Lamb1	6771	-983
Lamb2	2375	4485
Lamc1	7347	5936
Large1	6575	2464
Lars2	-6814	-414
Leo1	-296	-4202
Lgals1	7095	3320
Lman1	-1130	-5060
Lman1l	5574	5946
Lman2	-2352	-4702
Lman2l	-4616	-4849
Lmcd1	7505	6929
Lmna	7232	6208
Lmo7	-6191	-7085
Lonp2	-5285	-6862
Lrrc41	966	-1424
Lrrc49	4184	4581
Lsamp	-5205	-5188
Ltbp1	2153	4810
Ly6e	-1998	2785
Lypd1	4759	5476
Magt1	-5441	-7480
Man1a	664	-2507
Man1a2	5867	5756
Man1b1	-176	-2291
Man1c1	5900	2279
Man2a1	2682	1662
Man2a2	3550	-4096
Manea	3695	-1706
Map3k7	5998	6335
Mars2	-5106	-7011
Mat2b	-4828	-5899
Mavs	-7061	-7239
Mbd1	-5363	-4939
Mbd5	1632	-4215
Mbd6	-3688	-3438
Mbtps1	5821	5093
Mbtps2	3160	465
Mcfd2	2584	-5058
Mcrs1	-1979	-3193
Mdc1	-614	4189
Mdga1	-6235	-7180
Mdga2	-2444	-1744
Mdm2	4383	4102
Mdm4	-4108	-221
Men1	-3828	-2806
Mettl21a	6085	4409
Mettl22	-5940	-5677
Mfge8	5789	4710
Mgat1	1031	-2321
Mgat2	5212	2395
Mgat3	4996	-6874
Mgat4a	2446	753
Mgat4b	-4283	-4924
Mgat5	-1543	-3594
Mia2	-5629	-7819
Mia3	5790	3806
Mitf	-5982	-7409
Mlec	-932	-5239
Mme	-7081	-7744
Mmp2	7497	6885
Mogs	2989	-751
Mpdu1	5512	3468
Mpi	-7175	-6989
Mrpl1	-6750	-7265
Mrpl10	-5595	-5933
Mrpl11	-5991	-5910
Mrpl12	-7029	-6604
Mrpl13	-5916	-6619
Mrpl14	-6990	-6964
Mrpl15	-6574	-6827
Mrpl16	-5878	-6598
Mrpl17	-5372	-4564
Mrpl18	-6929	-7035
Mrpl19	-6834	-6958
Mrpl2	-7320	-7372
Mrpl20	-5318	-4089
Mrpl21	-5591	-6947
Mrpl22	-5839	-6141
Mrpl23	-6924	-4943
Mrpl24	-5493	-4092
Mrpl27	-4868	-4867
Mrpl28	-6906	-7373
Mrpl3	-6890	-7156
Mrpl30	-7337	-7761
Mrpl32	-5449	-6000
Mrpl33	-676	3231
Mrpl34	-6559	-6570
Mrpl35	-6678	-7167
Mrpl36	-4714	-4959
Mrpl37	-6747	-7068
Mrpl38	-6844	-6174
Mrpl39	-6696	-7130
Mrpl4	-6884	-6566
Mrpl40	-3530	-4283
Mrpl41	-6758	-6786
Mrpl42	-7248	-7608
Mrpl43	-5164	-5466
Mrpl44	-6513	-6841
Mrpl45	-6896	-7603
Mrpl46	-6817	-7379
Mrpl47	-6690	-6931
Mrpl48	-4965	-2296
Mrpl49	-5909	-5838
Mrpl50	-6278	-7053
Mrpl51	-7056	-7044
Mrpl52	-994	253
Mrpl53	-6252	-4354
Mrpl54	-1065	-2562
Mrpl55	-7064	-6715
Mrpl57	-2056	-4071
Mrpl58	-6710	-6615
Mrpl9	-6996	-7202
Mrps10	-1566	1880
Mrps11	-5399	-5798
Mrps12	-4262	-4111
Mrps14	-6073	-6439
Mrps15	-6805	-6956
Mrps16	-6308	-6130
Mrps17	-7178	-7576
Mrps18a	-6175	-6605
Mrps18b	-5938	-4872
Mrps18c	-5687	-6088
Mrps2	-6425	-7205
Mrps21	-6827	-7070
Mrps22	-5305	-6723
Mrps23	-6635	-5774
Mrps24	-6748	-6081
Mrps25	-6490	-6633
Mrps26	-5415	-3403
Mrps27	-6764	-7263
Mrps28	-6850	-6886
Mrps30	-6407	-6943
Mrps31	-6624	-7462
Mrps33	-6284	-6495
Mrps34	-6156	-4884
Mrps35	-7210	-7615
Mrps36	-6283	-6967
Mrps5	-6689	-6857
Mrps6	-4817	-1971
Mrps7	-6460	-6613
Mrps9	-6971	-7623
Mrrf	-6453	-6787
Mrtfa	5622	4869
Msln	2360	-3630
Msra	3793	-3041
Msrb1	-6959	-5720
Msrb2	-7107	-7648
Msrb3	64	-1836
Mta1	1936	-815
Mtfmt	-3436	-3006
Mtif2	-6744	-7351
Mtif3	-5780	-5500
Mtrf1l	-5597	-5796
Muc15	6986	6914
Muc16	-1221	-3095
Mul1	-6517	-6188
Mvd	-786	1263
Mxra8	7331	6704
Myc	6780	6070
Mydgf	1991	0
Myo5a	6359	5343
Mysm1	3238	3219
N6amt1	-2262	-4037
Nae1	-3256	-2608
Nagk	3592	-731
Nanp	2835	1684
Nans	6392	4932
Napa	-5159	-4315
Napb	1860	6167
Napg	2133	3081
Napsa	1416	1221
Nars2	-6694	-7073
Ncoa1	-4484	-6419
Ncoa2	-3912	-6801
Ncor2	4764	3742
Ncstn	2223	347
Ndc1	-3676	-4825
Nedd8	95	641
Negr1	5823	5771
Neu1	-4503	-122
Neu3	-2654	-2701
Neurl2	-6507	-6698
Nfkb2	6343	5577
Nfkbia	364	2648
Nfrkb	-839	5494
Nfya	-3456	1336
Nfyb	-2643	-1716
Nfyc	-6029	-6006
Ngly1	845	711
Nicn1	-3678	-5020
Nlrp3	1933	-1926
Nod1	-5920	-4982
Nod2	-2691	-746
Nop56	-2467	4524
Nop58	4067	3927
Npl	2978	1243
Nppa	7523	7032
Nr1h2	-243	1102
Nr1h3	-1853	-4977
Nr1h4	4445	220
Nr2c1	191	-3205
Nr3c1	2927	-1142
Nr3c2	-4800	-3832
Nr4a2	5256	96
Nr5a2	-4208	-4606
Nrip1	5461	5212
Nrn1	-3492	-3377
Nsf	-957	-3637
Nsmce1	-5506	-1406
Nsmce2	-3422	-2840
Nsmce3	3256	-54
Nsmce4a	-5118	-4113
Ntm	-213	-2420
Ntng2	3561	-2847
Nub1	2307	-58
Nucb1	5146	-1685
Nudt14	-7278	-7587
Nup107	-1252	-1977
Nup133	-2488	-1920
Nup153	608	1264
Nup155	3051	361
Nup160	2576	936
Nup188	1219	1677
Nup205	-670	-3324
Nup210	-5985	-6834
Nup214	-1565	-479
Nup35	1447	-1156
Nup37	-326	-4277
Nup43	-462	-1511
Nup50	-566	-2471
Nup54	-939	-4619
Nup62	-5422	-4685
Nup85	-2481	-84
Nup88	-1840	-4528
Nup93	4359	4421
Nup98	3276	-3680
Nupl2	-3657	-3335
Nus1	1719	-1890
Obsl1	-2906	-269
Ogt	-1553	3555
Opcml	-5635	-6432
Os9	4038	2735
Otoa	4826	1919
Otub1	-3425	-4214
Otub2	3988	5376
Otud3	684	1464
Otud5	3923	4580
Otud7b	6943	4170
Otulin	7371	6868
Oxa1l	-7035	-6627
P2ry2	1396	142
P4hb	6441	4378
Paf1	876	1604
Pappa	5106	5735
Pappa2	2103	2774
Park7	3045	2712
Parn	5923	3560
Parp1	-6470	-6763
Pars2	-3576	-3342
Pcgf2	7012	6229
Pcmt1	-2784	-2245
Pcna	-491	3253
Pdcl	2816	-2475
Pdia3	2332	353
Pdia5	5791	-3923
Pdia6	-3081	-4513
Penk	-5937	-6873
Pex10	-6076	-6073
Pex12	2346	-4157
Pex13	-771	-5620
Pex14	809	-2777
Pex2	-5398	-6265
Pex5	5993	2191
Pfdn1	134	-1945
Pfdn2	-4986	-4399
Pfdn5	-3006	-1418
Pfdn6	-6140	-4807
Pgap1	-3269	-6849
Pgm3	5901	4554
Phc1	5898	3435
Phc2	3502	2510
Phc3	-552	3145
Pias1	-3854	-4772
Pias2	-2385	-3541
Pias3	4948	3899
Pias4	-3508	-2197
Piga	-1378	15
Pigb	431	-265
Pigc	-3106	-2353
Pigf	-892	3863
Pigg	-3894	-5544
Pigh	-3742	-4955
Pigk	4908	-2466
Pigl	1797	30
Pigm	2685	1819
Pign	3984	422
Pigo	-6392	-6986
Pigp	-4229	-3926
Pigq	-3365	-3974
Pigs	4429	1208
Pigt	4883	-20
Pigu	-4212	-2276
Pigv	-4809	-5582
Pigw	-2428	-1307
Pigx	-3211	-3681
Pigyl	-5429	-5676
Pla2g7	-367	-3957
Plaur	1827	-1274
Plet1	6130	6827
Pml	3342	3906
Pmm1	7486	6895
Pmm2	-3323	-5784
Pnpla2	-6697	-6659
Pofut2	6423	1428
Polb	-2364	277
Pom121	-5732	-2088
Pomgnt1	-3527	3647
Pomgnt2	-4342	-3958
Pomk	2538	1457
Pomt1	-3764	-5028
Pomt2	-1986	-206
Ppa1	-3881	-5184
Ppa2	-6676	-6918
Ppara	-6545	-7563
Pparg	-4842	-2722
Ppargc1a	-6363	-7511
Ppp2r5b	2746	2750
Ppp6c	-3624	-5684
Ppp6r1	-5185	-4073
Ppp6r3	-5054	-6661
Preb	-5765	-4262
Prkcsh	2629	2190
Prkdc	4840	6764
Prmt3	324	429
Pros1	5170	3887
Proz	-2135	1826
Prss23	4876	2314
Psenen	1615	1894
Psg16	-4834	6002
Psma1	-5057	-5354
Psma3	-1668	-1270
Psma4	-4195	-5256
Psma5	917	4879
Psma6	-6198	-4392
Psma7	-5203	-1132
Psmb1	-3490	-1504
Psmb10	3247	6154
Psmb2	-6229	-6389
Psmb3	-6394	-4507
Psmb4	-4157	-2719
Psmb5	-5358	-2463
Psmb6	-5905	-4631
Psmb7	-6295	-6022
Psmb8	188	2895
Psmb9	239	987
Psmc1	-4509	-1482
Psmc2	-5438	-4371
Psmc3	-5727	-3198
Psmc4	580	1965
Psmc5	-5068	-3092
Psmc6	-3319	55
Psmd1	-4493	-2930
Psmd10	2830	-1174
Psmd11	5474	5901
Psmd12	-5949	-6045
Psmd13	2269	4514
Psmd14	1389	1667
Psmd2	-4258	-2549
Psmd3	-5414	-2387
Psmd4	-73	2814
Psmd5	2751	2805
Psmd6	-2219	-3583
Psmd7	-3344	2462
Psmd8	5830	6151
Psmd9	811	-3604
Psme1	-7082	-7176
Psme2b	-2823	-3837
Psme3	-4430	-5111
Psme4	-5860	-5252
Psmf1	1562	263
Ptcd3	-7230	-7612
Pten	679	-2222
Ptp4a2	2596	-3793
Ptrh2	-2796	-2597
Pum2	-36	-3862
Qsox1	7490	6703
Rab10	-4439	-5212
Rab11a	-2501	-5885
Rab11b	1212	-3386
Rab12	-5280	-6895
Rab13	6900	6349
Rab14	-5276	-6634
Rab15	7415	6757
Rab17	-6502	-6310
Rab18	-1250	-4021
Rab1a	-3223	-6062
Rab1b	-6030	-5486
Rab20	-1334	-2750
Rab21	-4812	-6186
Rab22a	-2394	-3903
Rab23	5397	5291
Rab24	-4445	-4221
Rab27a	-1179	-3721
Rab27b	7417	6961
Rab29	3606	2590
Rab2a	2739	-1349
Rab2b	5649	2106
Rab30	-3630	-2354
Rab31	7227	6762
Rab33b	6021	3134
Rab34	6739	5997
Rab35	5336	845
Rab36	4621	4563
Rab37	-508	-4370
Rab3a	-6304	-4824
Rab3d	4802	2649
Rab40b	6127	-3597
Rab40c	1260	-3488
Rab42	-3188	-3257
Rab43	4039	2459
Rab4a	1717	2240
Rab4b	6975	6460
Rab5a	5098	86
Rab5b	-1911	-4750
Rab5c	3142	-1160
Rab6a	6083	2806
Rab6b	4327	1836
Rab7	-5369	-6377
Rab7b	6565	5190
Rab8a	1372	1357
Rab8b	4850	2440
Rab9	-2739	-6338
Rabggta	-4972	-3450
Rabggtb	-3434	-1391
Rad18	5613	6072
Rad21	-3255	-4850
Rad23a	-3757	-4095
Rad23b	-4644	-4605
Rad52	3995	5491
Rae1	-2439	-1886
Ranbp2	1943	-1227
Rangap1	3393	3196
Rara	6256	3952
Rars2	-5676	-5759
Rbbp5	-4856	-6187
Rbbp7	-5747	-6737
Rbx1	-4743	-4554
Rce1	2503	1879
Reck	6833	5647
Rela	4961	3728
Renbp	4245	2617
Rft1	3829	-5039
Rgs11	4854	5703
Rgs6	-6443	-3786
Rgs7	-5993	4356
Rhoa	-857	-3472
Rhot1	-5531	-6842
Ring1	3578	1778
Ripk1	3817	949
Ripk2	1005	3673
Rnf103	6849	6352
Rnf123	-6472	-6103
Rnf128	-5287	-6328
Rnf139	-5444	-5644
Rnf144a	-559	-5331
Rnf146	-2003	400
Rnf152	-1671	-1422
Rnf168	-3229	-3171
Rnf181	3668	3650
Rnf185	-3305	-2631
Rnf2	6290	-1872
Rnf20	1561	-903
Rnf40	-2967	501
Rnf5	-5268	-4979
Rnf7	-4623	-5468
Rora	4753	1898
Rpa1	-4117	-3049
Rpl10-ps3	3212	1228
Rpl10a	2365	826
Rpl11	-1842	-1611
Rpl12	4829	5011
Rpl13	-1673	-925
Rpl13a	3206	1423
Rpl14	-1056	-1817
Rpl18	-544	-2116
Rpl18a	-1661	-1683
Rpl19	1021	-223
Rpl22l1	-697	990
Rpl23	893	-998
Rpl26	-440	315
Rpl27	-3812	-3262
Rpl28	-3522	-3053
Rpl29	-3071	-3308
Rpl3	6113	6294
Rpl30	-2113	-2803
Rpl32	210	-2635
Rpl34	639	-1667
Rpl35	-731	-1020
Rpl36	-4693	-3549
Rpl37a	1027	-952
Rpl38	2973	-609
Rpl3l	-7308	-7793
Rpl4	2299	-567
Rpl5	767	2478
Rpl6	-669	-2330
Rpl7a	-2054	-3718
Rpl8	-4247	-3018
Rplp1	1737	1206
Rpn1	-584	-2591
Rpn2	2811	1591
Rps11	315	-2551
Rps12	2728	884
Rps13	-5050	-5764
Rps14	-1071	-1798
Rps15	-1045	-2489
Rps15a	-3231	-2769
Rps16	900	-494
Rps17	-4875	-5562
Rps19	-44	-2802
Rps20	2098	1064
Rps21	1421	-1394
Rps24	69	-130
Rps25	-2930	-2703
Rps27a	-1504	-1029
Rps27l	282	1037
Rps28	3137	-561
Rps3a1	-1317	-1655
Rps4x	810	-303
Rps5	1452	1852
Rps7	-2886	-1733
Rps8	1432	-1256
Rps9	-212	-1205
Rpsa	-3636	-3074
Rraga	2409	-2434
Rtf1	-3806	-6273
Rtn4rl1	-1725	1368
Rtn4rl2	-4264	-4798
Ruvbl1	1316	3391
Rwdd3	3019	-1423
Rxra	-6194	-6804
Sae1	2956	1409
Safb	-4300	-2110
Sar1b	-6848	-7206
Sars2	-6953	-6965
Satb1	6347	5016
Satb2	2575	-274
Scfd1	2215	832
Scg3	6324	4487
Scmh1	-6058	-6434
Sdc2	7435	6631
Sec11a	2983	-1386
Sec11c	2545	-783
Sec13	1575	39
Sec16a	572	-4601
Sec16b	7226	6671
Sec22a	-1779	-5709
Sec22b	5609	3487
Sec22c	4146	194
Sec23a	4506	-802
Sec23ip	4637	-3059
Sec24a	-95	-2344
Sec24b	4189	3729
Sec24d	6468	5064
Sec31a	1581	2182
Sec61a1	6371	4324
Sec61a2	-4893	-5428
Sec61b	5315	1434
Sec61g	-4065	-1345
Seh1l	326	-1812
Sel1l	3457	1172
Selenos	6071	698
Sema5a	6936	5951
Sema5b	2698	-5908
Senp1	-2543	1300
Senp2	962	3281
Senp5	267	-299
Senp8	-4352	-5119
Serp1	5557	2548
Serpina1d	-3938	1913
Serpinc1	-2974	1289
Shc1	5764	3996
Shisa5	3383	5045
Shprh	309	2000
Siah1b	2256	-1509
Siah2	-5606	-2244
Sin3a	625	-2529
Skiv2l	3869	2096
Skp1a	-2255	-5461
Skp2	3484	2048
Slc17a5	4456	2342
Slc30a5	-7	2470
Slc30a6	-1597	486
Slc30a7	4859	3739
Slc35a1	4230	111
Slc35c1	2466	1410
Smad1	5072	4831
Smad2	2945	-931
Smad3	3925	-4081
Smad4	4924	4471
Smad7	6193	5962
Smc1a	3576	445
Smc3	1642	-3069
Smc5	5628	2670
Smc6	-334	-4308
Smurf2	5768	4293
Snca	49	-641
Sncaip	-1768	-4852
Snx3	-3539	-3143
Socs2	2278	5477
Socs3	2520	-1464
Socs5	2323	-1732
Socs6	2568	3445
Sorl1	6884	6834
Sp3	4085	-1728
Sparcl1	5012	6004
Spcs1	2963	780
Spcs2	1459	-541
Sphk1	6933	6215
Spon1	3365	1636
Spon2	5148	2625
Spp1	4125	6580
Sprn	4349	2201
Spsb1	-5562	-4000
Spsb2	6887	6147
Spsb3	-3713	1094
Spsb4	6310	6145
Spta1	-2545	-5699
Sptan1	-525	5294
Sptb	-1715	1502
Sptbn1	-4084	-4692
Sptbn2	-1231	1110
Sptbn5	3367	6778
Srd5a3	4993	3726
Srp14	-2787	-1078
Srp19	-3428	-4816
Srp54a	-729	-3696
Srp68	-2008	-1774
Srp72	1277	-916
Srp9	-2636	-3551
Srpr	1234	-2564
Srprb	-2399	-694
Ssr1	6057	4618
Ssr2	2857	-2085
Ssr3	4310	-3996
Ssr4	1754	-2097
St3gal1	3058	716
St3gal2	6995	5852
St3gal3	-6777	-6624
St3gal4	4466	-4957
St3gal5	5507	3409
St3gal6	-4673	-4593
St6gal1	4351	-2022
St6galnac2	5684	-2059
St6galnac3	48	-5018
St6galnac4	6331	6062
St6galnac6	-7184	-7584
St8sia1	6367	6714
St8sia2	4491	4888
St8sia4	-6404	-5155
St8sia6	-1521	-4549
Stag1	-170	1246
Stag2	5515	3921
Stam	1544	-52
Stam2	5387	2587
Stambp	6297	5429
Stambpl1	4305	5397
Stat3	4087	345
Stc2	3421	3269
Stt3a	6426	4330
Stx17	759	-2924
Stx1a	2912	1003
Stx5a	4418	3544
Suds3	-2154	-3527
Sult5a1	7465	469
Sumf1	6244	3765
Sumo1	-3315	-3990
Sumo2	-1525	-5695
Sumo3	-2452	-3372
Suz12	-226	-4267
Syvn1	250	-3418
Tab1	213	-3626
Tada2b	-5030	-5237
Tada3	1408	2330
Taf10	516	-1095
Taf9b	-2156	-2674
Tars	3361	754
Tars2	-6442	-5956
Tatdn2	-5829	-2800
Tbc1d20	3878	3019
Tbca	2304	3903
Tbcb	5157	405
Tbcc	5458	2544
Tbcd	4828	2466
Tbce	5890	1441
Tcf7l2	1954	-4942
Tcp1	-4116	-4139
Tdg	2462	2630
Tfg	-1929	-4911
Tfpt	-2922	-2349
Tgfa	6309	4116
Tgfb1	6984	5531
Tgfbi	6894	5593
Tgfbr1	7285	6857
Tgfbr2	6843	5799
Tgoln1	-601	-3932
Thbs1	6742	6178
Thbs2	4196	3190
Thra	-1052	-3657
Thrb	-4935	-6414
Thsd1	-116	288
Thsd4	995	6395
Thsd7a	6779	6825
Thy1	-5194	-4359
Timp1	7129	6798
Tln1	6888	5990
Tmed10	5429	480
Tmed2	4476	-272
Tmed3	6576	6027
Tmed7	-747	-6167
Tmed9	3775	-3777
Tmem115	-2170	-121
Tmem129	-1574	-1433
Tmem132a	6428	5094
Tnc	4757	6330
Tnfaip3	5930	5656
Tnip1	7399	6677
Tnip2	5614	6046
Tnip3	-4764	-6577
Tnks	3088	977
Tnks2	-4497	-6705
Tomm20	-4097	-410
Tomm70a	-5828	-6506
Top1	-5309	-5957
Top2a	3941	5034
Top2b	2878	1766
Topors	1301	-1815
Tpgs1	3574	1245
Tpgs2	241	-2322
Tpp1	-2117	-3484
Tpr	5510	4178
Traf2	-9	1142
Traf3	6586	6515
Traf6	513	-1168
Tram1	6017	4182
Trappc1	-3692	-2484
Trappc10	-5862	-6859
Trappc2l	-5623	-3826
Trappc3	-2835	-4059
Trappc4	-2363	396
Trappc5	-2308	-3230
Trappc6a	3326	-3504
Trappc6b	1361	1137
Trappc9	-4762	-5251
Trf	5836	4229
Trim13	-751	2199
Trim25	-2206	-558
Trim27	3068	1379
Trim28	2367	-424
Trmt112	390	1149
Trp53	4978	4881
Trp53bp1	3986	6150
Trrap	1560	1002
Tsfm	-6347	-6440
Tspan14	-2832	-3783
Tspan15	-5379	-6832
Tspan33	-2711	-5318
Tspan5	5544	5231
Tspyl2	1341	4480
Tsta3	-4656	-3516
Ttf1	-884	-778
Ttl	-2331	-1603
Ttll1	-7332	-7589
Ttll11	4866	5271
Ttll12	5659	5340
Ttll13	3101	3392
Ttll3	-4374	-366
Ttll4	-3396	-50
Ttll7	6049	6261
Ttr	-2307	6470
Tuba1a	6556	6170
Tuba1b	-1269	4961
Tuba1c	1978	4986
Tuba4a	-6071	-6762
Tuba8	-6373	-2061
Tubb1	4485	-1601
Tubb2a	6210	6696
Tubb2b	6374	6367
Tubb3	6801	5192
Tubb4a	-3093	-4058
Tubb4b	-4356	359
Tubb6	3962	4109
Tufm	-6846	-7363
Tulp4	5707	6458
Tusc3	5313	4277
Txn1	1859	953
Uap1	-4914	-3592
Uba1	3207	-97
Uba2	5031	4388
Uba3	-4779	-6110
Uba6	4311	-2236
Ubb	5763	-1908
Ubc	-1436	-1699
Ube2a	-5301	-5570
Ube2b	-6925	-7329
Ube2c	5815	4785
Ube2d1	-4576	-5721
Ube2d2a	-681	-3716
Ube2d3	5709	3978
Ube2e1	3650	-762
Ube2e3	-3833	-6596
Ube2f	-5852	-3010
Ube2g1	2479	-2994
Ube2g2	973	476
Ube2h	4381	-1749
Ube2i	3577	1079
Ube2j2	-2625	-2495
Ube2k	-2821	-4679
Ube2l6	-127	4621
Ube2m	-4813	-4591
Ube2n	-5254	-5400
Ube2q2	4037	-886
Ube2r2	-6384	-6380
Ube2s	-1064	-1454
Ube2t	-2298	-1230
Ube2v2	3853	-647
Ube2w	2917	1334
Ube2z	5974	2915
Ubxn1	6883	5851
Ubxn7	3794	895
Uchl1	7520	7020
Uchl3	-4443	-5303
Uchl5	843	1974
Ucn	3274	1169
Uggt1	2756	1971
Uggt2	4732	4979
Uhrf2	-3776	27
Uimc1	492	683
Ulbp1	7471	6806
Uso1	6091	4331
Usp10	-4635	-4904
Usp11	5734	6601
Usp12	-4222	-76
Usp13	1158	556
Usp14	-4744	-5855
Usp15	-3781	-6687
Usp16	2091	-2373
Usp18	-2557	6813
Usp19	-3536	-3655
Usp2	-6852	-5821
Usp20	2677	3781
Usp21	-2867	-2653
Usp22	6065	2316
Usp24	-5522	-5332
Usp25	-1941	2411
Usp28	6295	6563
Usp3	-80	-4502
Usp30	2724	756
Usp33	-3062	-3495
Usp34	2213	1140
Usp37	-2310	-2993
Usp4	-1225	3358
Usp42	4380	1358
Usp47	5685	5938
Usp48	-2652	-1281
Usp49	-43	1229
Usp5	-2839	-2731
Usp7	931	-1139
Usp8	-495	-2761
Usp9x	4374	-3676
Vamp2	-3875	-96
Vars2	-6968	-6459
Vbp1	-3374	-1998
Vcan	7188	6694
Vcp	-2921	-3485
Vcpip1	3357	127
Vcpkmt	4204	5637
Vdac1	-7008	-7195
Vdac2	-6648	-6666
Vdac3	-6938	-7147
Vdr	-724	-161
Vwa1	6270	5237
Wac	-15	-2599
Wars2	-4658	-5948
Wdr20	-3789	-5419
Wdr48	-3036	-816
Wdr5	-4297	-6236
Wdr61	2151	1382
Wdtc1	-6639	-6253
Wfs1	6267	3063
Wipi1	965	-4533
Wrap53	-3248	-5260
Wrn	1430	-190
Wsb1	6133	1315
Wsb2	5015	773
Xbp1	661	-2968
Xpc	-2318	-2619
Xpnpep2	-3342	-1937
Xrcc4	2600	1022
Xrn2	5320	-4035
Yars2	-6001	-7155
Yif1a	-3722	-5122
Ykt6	4836	-818
Yod1	-3054	2123
Yy1	-1198	-3412
Zbtb16	-3608	-1995
Zbtb17	-3343	-3490
Zdhhc2	4482	5490
Zfp131	-2752	-3202
Zranb1	2057	2432

---

---

Integrin-cell-surface-interactions

Integrin-cell-surface-interactions

metric	value
setSize	53
pMANOVA	1.23e-07
p.adjustMANOVA	3.14e-06
s.dist	0.602
s.young	0.43
s.old	0.421
p.young	5.95e-08
p.old	1.12e-07

Top 20 genes

Gene	young	old
Cd44	7295	7013
Col16a1	7349	6856
Itga5	7309	6750
Col4a3	7037	6967
Itgav	7314	6700
Col4a4	7049	6807
Col9a2	7498	6397
Fn1	7320	6491
Lum	7163	6376
Itga11	6898	6561
Itgb5	7035	6117
Itgb3	7496	5721
Fbn1	6968	6107
Itgb8	6492	6501
Thbs1	6742	6178
Itga9	6082	6594
Itgb1	6770	5825
Itga7	6140	5835
Col18a1	6116	5391
Comp	4501	6797

Click HERE to show all gene set members

All member genes

	young	old
Agrn	-247	199
Bsg	-6548	-7267
Cd44	7295	7013
Cd47	4738	3661
Col13a1	2636	3872
Col16a1	7349	6856
Col18a1	6116	5391
Col23a1	5725	2177
Col4a1	5635	5181
Col4a2	5963	4644
Col4a3	7037	6967
Col4a4	7049	6807
Col9a2	7498	6397
Comp	4501	6797
F11r	-352	-4343
Fbn1	6968	6107
Fga	-3043	855
Fgb	-3889	1327
Fn1	7320	6491
Hspg2	6535	3769
Icam1	5132	3799
Icam2	-2435	-4834
Itga1	-2422	-3850
Itga11	6898	6561
Itga2	3765	6228
Itga2b	5803	437
Itga3	5715	5066
Itga4	610	3065
Itga5	7309	6750
Itga6	-5055	-3078
Itga7	6140	5835
Itga8	3673	5405
Itga9	6082	6594
Itgae	4962	3911
Itgal	2820	-2156
Itgav	7314	6700
Itgax	1846	526
Itgb1	6770	5825
Itgb3	7496	5721
Itgb5	7035	6117
Itgb6	-4680	-6503
Itgb7	2293	3037
Itgb8	6492	6501
Jam2	-3753	-6183
Jam3	4176	3665
Kdr	-5777	-7016
Lum	7163	6376
Pecam1	-3282	-6290
Spp1	4125	6580
Thbs1	6742	6178
Tnc	4757	6330
Vcam1	4827	2422
Vtn	-7117	-7433

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0   GGally_2.0.0    beeswarm_0.2.3  gtools_3.8.2   
##  [5] echarts4r_0.3.2 mitch_1.0.6     gplots_3.0.3    reshape2_1.4.4 
##  [9] forcats_0.5.0   stringr_1.4.0   dplyr_1.0.0     purrr_0.3.4    
## [13] readr_1.3.1     tidyr_1.1.0     tibble_3.0.1    ggplot2_3.3.2  
## [17] tidyverse_1.3.0
## 
## loaded via a namespace (and not attached):
##  [1] nlme_3.1-148       bitops_1.0-6       fs_1.4.2           lubridate_1.7.9   
##  [5] RColorBrewer_1.1-2 httr_1.4.1         rprojroot_1.3-2    tools_4.0.2       
##  [9] backports_1.1.8    R6_2.4.1           KernSmooth_2.23-17 DBI_1.1.0         
## [13] colorspace_1.4-1   withr_2.2.0        tidyselect_1.1.0   gridExtra_2.3     
## [17] compiler_4.0.2     cli_2.0.2          rvest_0.3.5        xml2_1.3.2        
## [21] desc_1.2.0         labeling_0.3       caTools_1.18.0     scales_1.1.1      
## [25] digest_0.6.25      rmarkdown_2.3      pkgconfig_2.0.3    htmltools_0.5.0   
## [29] dbplyr_1.4.4       fastmap_1.0.1      highr_0.8          htmlwidgets_1.5.1 
## [33] rlang_0.4.6        readxl_1.3.1       rstudioapi_0.11    shiny_1.5.0       
## [37] generics_0.0.2     farver_2.0.3       jsonlite_1.7.0     magrittr_1.5      
## [41] Rcpp_1.0.4.6       munsell_0.5.0      fansi_0.4.1        lifecycle_0.2.0   
## [45] stringi_1.4.6      yaml_2.2.1         MASS_7.3-51.6      plyr_1.8.6        
## [49] grid_4.0.2         blob_1.2.1         parallel_4.0.2     gdata_2.18.0      
## [53] promises_1.1.1     crayon_1.3.4       lattice_0.20-41    haven_2.3.1       
## [57] hms_0.5.3          knitr_1.29         pillar_1.4.4       reprex_0.3.0      
## [61] glue_1.4.1         evaluate_0.14      modelr_0.1.8       vctrs_0.3.1       
## [65] httpuv_1.5.4       testthat_2.3.2     cellranger_1.1.0   gtable_0.3.0      
## [69] reshape_0.8.8      assertthat_0.2.1   xfun_0.15          mime_0.9          
## [73] xtable_1.8-4       broom_0.5.6        later_1.1.0.1      pbmcapply_1.5.0   
## [77] ellipsis_0.3.1

END of report