Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-02-01
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## young old
## 0610009B22Rik -2.9385024 -6.1805927
## 0610009E02Rik 0.6410018 -1.6821055
## 0610009L18Rik -4.5856767 -3.1288917
## 0610010F05Rik 0.6483013 0.4402823
## 0610010K14Rik -8.7879236 -3.0864256
## 0610012G03Rik -8.7415080 -6.4223694Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 14877 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 719 |
| num_profile_genes_not_in_sets | 14158 |
| profile_pearson_correl | 0.8374 |
| profile_spearman_correl | 0.80977 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets:
| Gene sets metrics | |
|---|---|
| num_genesets | 2 |
| num_genesets_excluded | 0 |
| num_genesets_included | 2 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 1 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 2 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.young | s.old | p.young | p.old |
|---|---|---|---|---|---|---|---|---|
| lipid biosynth | 508 | 0.000305 | 0.00061 | 0.1170 | -0.0619 | -0.0998 | 0.0176 | 0.000129 |
| lipid transport | 277 | 0.295000 | 0.29500 | 0.0242 | 0.0200 | -0.0137 | 0.5690 | 0.695000 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.young | s.old | p.young | p.old |
|---|---|---|---|---|---|---|---|---|
| lipid biosynth | 508 | 0.000305 | 0.00061 | 0.1170 | -0.0619 | -0.0998 | 0.0176 | 0.000129 |
| lipid transport | 277 | 0.295000 | 0.29500 | 0.0242 | 0.0200 | -0.0137 | 0.5690 | 0.695000 |
Detailed Gene set reports
lipid_biosynth
| metric | value |
|---|---|
| setSize | 508 |
| pMANOVA | 0.000305 |
| p.adjustMANOVA | 0.00061 |
| s.dist | 0.117 |
| s.young | -0.0619 |
| s.old | -0.0998 |
| p.young | 0.0176 |
| p.old | 0.000129 |
| Gene | young | old |
|---|---|---|
| Ceacam1 | -7351 | -7822 |
| Acsl6 | -7255 | -7818 |
| Acat1 | -7263 | -7711 |
| Dgat2 | -7202 | -7707 |
| Ndufab1 | -7247 | -7579 |
| Acadvl | -7306 | -7500 |
| St6galnac6 | -7184 | -7584 |
| Pik3r1 | -7121 | -7646 |
| Ces1d | -6932 | -7808 |
| Gnpat | -7105 | -7547 |
| Pla2g5 | -6711 | -7781 |
| Fdft1 | -6800 | -7660 |
| Acadl | -6920 | -7478 |
| Acsl1 | -6926 | -7461 |
| Gal3st3 | -6798 | -7588 |
| Dhrs11 | -6886 | -7465 |
| Hsd17b10 | -6937 | -7410 |
| Coq2 | -7039 | -7275 |
| Gpat3 | -6774 | -7555 |
| Acacb | -6936 | -7366 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| A4galt | 3385 | 4341 |
| Abca2 | -4137 | -4471 |
| Abca3 | -2208 | -1813 |
| Abca8a | 7291 | 6385 |
| Abca8b | 6696 | 6368 |
| Abcd1 | -6190 | -6228 |
| Abcd2 | -5558 | -4862 |
| Abcd3 | -6653 | -7370 |
| Abcg1 | 4372 | 4144 |
| Abhd2 | 7119 | 6408 |
| Abhd3 | -1534 | -4787 |
| Abhd4 | 6723 | 4307 |
| Abhd5 | -5259 | -6321 |
| Abhd6 | -3892 | -5847 |
| Abhd8 | -3070 | -2068 |
| Acaca | 3453 | -653 |
| Acacb | -6936 | -7366 |
| Acadl | -6920 | -7478 |
| Acadvl | -7306 | -7500 |
| Acat1 | -7263 | -7711 |
| Acbd3 | 2132 | 3045 |
| Acer2 | 3412 | -4615 |
| Acer3 | -4605 | -2376 |
| Acly | -3791 | -3425 |
| Acot7 | -5971 | -6960 |
| Acsf3 | -6626 | -7575 |
| Acsl1 | -6926 | -7461 |
| Acsl3 | 2818 | -794 |
| Acsl4 | 4513 | 954 |
| Acsl5 | 3226 | 5103 |
| Acsl6 | -7255 | -7818 |
| Acss1 | -6305 | -7406 |
| Acss2 | -2290 | -928 |
| Adgrf5 | -6023 | -7340 |
| Agk | -4625 | -6343 |
| Agmo | 3384 | 5619 |
| Agpat1 | -4882 | -3988 |
| Agpat2 | -6388 | -6657 |
| Agpat3 | -6640 | -7071 |
| Agpat4 | 4662 | 6089 |
| Agpat5 | -6415 | -5448 |
| Agps | -605 | -2899 |
| Agt | -4320 | -6233 |
| Ajuba | 4368 | 1241 |
| Akt1 | -6210 | -5765 |
| Aldh1a1 | 7190 | 6038 |
| Aldh1a2 | 5436 | -3233 |
| Aldh1a3 | 6915 | 6545 |
| Aldh8a1 | 696 | 1793 |
| Alox12 | -652 | -4906 |
| Alox5 | -6090 | -7663 |
| Alox8 | -2406 | 3609 |
| Amacr | -6767 | -7086 |
| Ang | 4534 | 1983 |
| Anxa1 | 7137 | 6423 |
| Apoa1 | -3117 | -370 |
| Apoa2 | -4104 | -1788 |
| Apob | -2312 | 1254 |
| Apoe | 948 | -334 |
| Armc5 | 5351 | 2103 |
| Asah1 | 6043 | 3973 |
| Asah2 | 1176 | -4555 |
| Asxl3 | 1582 | 1062 |
| Atg14 | -998 | -2428 |
| Atg7 | 4407 | 2040 |
| Atp1a1 | -6556 | -6452 |
| Avil | 2315 | 4996 |
| Avpr1a | -5760 | -6645 |
| B3galt1 | 5246 | 6656 |
| B3galt2 | 6942 | 6534 |
| B3galt4 | 3003 | 4149 |
| B3gnt5 | 4473 | 902 |
| B4galnt1 | 5962 | 6221 |
| B4galt3 | -4310 | -1405 |
| B4galt4 | -4249 | -652 |
| B4galt5 | 6407 | 5561 |
| B4galt6 | 6036 | 6103 |
| Becn1 | 4044 | 1659 |
| Bmp2 | -2270 | 2145 |
| Bmp5 | -203 | -3316 |
| Bmp6 | 1386 | -3614 |
| Bpnt1 | -5976 | -4937 |
| Brca1 | 3122 | 4948 |
| Bscl2 | 3895 | 2520 |
| C3 | -1415 | -6719 |
| Cacna1h | -5989 | -3640 |
| Capn2 | 6302 | 6179 |
| Cbr4 | -6830 | -7226 |
| Ccdc3 | -3609 | 5180 |
| Ccn1 | 7344 | 6244 |
| Cd74 | -3174 | -6543 |
| Cdipt | -1066 | 1943 |
| Cdk4 | 3801 | 980 |
| Cds1 | 4034 | -6561 |
| Cds2 | -4274 | -3035 |
| Ceacam1 | -7351 | -7822 |
| Cept1 | -4667 | -4738 |
| Cerkl | 3755 | 4615 |
| Cers1 | 6667 | 3448 |
| Cers2 | 4517 | 5812 |
| Cers4 | 775 | 433 |
| Cers5 | 985 | 4266 |
| Cers6 | 7092 | 3598 |
| Ces1d | -6932 | -7808 |
| Ch25h | 4808 | 3678 |
| Chka | 4684 | 3845 |
| Chkb | -6441 | -7178 |
| Chp1 | -1311 | -5595 |
| Chpt1 | -7142 | -6809 |
| Cish | -5557 | -3161 |
| Clcn2 | 4005 | 1580 |
| Cln3 | 778 | -186 |
| Cnep1r1 | -90 | -3451 |
| Coq2 | -7039 | -7275 |
| Creb1 | -3517 | -2558 |
| Crebl2 | -1103 | -3278 |
| Crls1 | -2528 | -6363 |
| Crppa | 3023 | 2275 |
| Ctdnep1 | -6486 | -5825 |
| Cyb5r1 | 6442 | 6499 |
| Cyb5r2 | -6010 | -7106 |
| Cyb5r3 | 7460 | 6850 |
| Cyp27a1 | 4250 | 3986 |
| Cyp2r1 | 2096 | 2307 |
| Cyp39a1 | 5373 | 3249 |
| Cyp51 | 1692 | -4686 |
| Cyp7b1 | -361 | -1822 |
| Dab2 | 5377 | 3411 |
| Daglb | 6108 | 5773 |
| Dbi | -6324 | -6808 |
| Dctn6 | -5983 | -6121 |
| Ddx20 | -3002 | -3567 |
| Decr2 | -2640 | -3902 |
| Degs1 | -2289 | -5288 |
| Degs2 | -1416 | 993 |
| Dgat1 | -4190 | -4756 |
| Dgat2 | -7202 | -7707 |
| Dgka | -4870 | -4501 |
| Dgkb | 2754 | 4349 |
| Dgkd | 5922 | 5645 |
| Dgke | -6208 | -5221 |
| Dgkg | -2589 | 6777 |
| Dgkh | -4773 | -3197 |
| Dgkq | -3202 | 728 |
| Dgkz | -5865 | -1113 |
| Dhcr24 | 2696 | 5785 |
| Dhcr7 | -1331 | -2195 |
| Dhdds | 4837 | 4695 |
| Dhh | -3543 | 2164 |
| Dhrs11 | -6886 | -7465 |
| Dhrs7b | 701 | 2189 |
| Dhrs9 | 4412 | 6006 |
| Dkk3 | 7345 | 6471 |
| Dolk | -5587 | -3086 |
| Dolpp1 | 921 | -3874 |
| Dpm1 | -1101 | -5227 |
| Dpm2 | 4502 | 2233 |
| Dpm3 | 1522 | -4346 |
| Ebp | -4138 | 3561 |
| Edn1 | 6861 | 48 |
| Efr3b | -5242 | -4823 |
| Egr1 | 6800 | 2934 |
| Eif6 | 6826 | 4848 |
| Elovl1 | 5112 | 5663 |
| Elovl5 | -3997 | -5603 |
| Elovl6 | 3634 | 2877 |
| Elovl7 | 4758 | -245 |
| Erbb4 | -4933 | -5991 |
| Erg28 | -104 | -1765 |
| Erlin1 | -1136 | 3029 |
| Erlin2 | 1875 | -5927 |
| Etnk1 | -4063 | -5539 |
| Etnk2 | -2993 | 2158 |
| Fabp3 | -5416 | -6575 |
| Fabp5 | -285 | -5130 |
| Fads1 | 6269 | 5837 |
| Fads2 | 6205 | 6018 |
| Fads3 | 6221 | 510 |
| Fads6 | -3986 | -4229 |
| Fam126a | -6120 | -4744 |
| Fam126b | 5073 | 5813 |
| Fam3a | 1763 | -681 |
| Far1 | 5654 | 4954 |
| Fasn | 4789 | 4808 |
| Fdft1 | -6800 | -7660 |
| Fdps | -3157 | -4647 |
| Fdx1 | -6618 | -6735 |
| Fgf1 | -6409 | -6042 |
| Fgf2 | 3347 | -4613 |
| Fgf7 | 689 | -852 |
| Fitm1 | -7108 | -6932 |
| Fitm2 | -6960 | -7139 |
| Fut4 | 107 | -1713 |
| G6pdx | 3633 | 3514 |
| Gal3st3 | -6798 | -7588 |
| Gba | 6569 | 5896 |
| Ggps1 | 1607 | 787 |
| Gm44502 | -4541 | -60 |
| Gnpat | -7105 | -7547 |
| Gpaa1 | -4670 | -1612 |
| Gpam | -6358 | -7122 |
| Gpat3 | -6774 | -7555 |
| Gpat4 | -1288 | -3108 |
| Gper1 | -743 | -562 |
| Gpld1 | -2570 | -4883 |
| Gstm4 | -132 | -2249 |
| Gstm7 | -7077 | -6817 |
| Gstp1 | -5950 | -3595 |
| Gstp2 | -5200 | -3677 |
| H2-Ke6 | -6180 | -5754 |
| H6pd | -3577 | -3301 |
| Hacd1 | -4729 | 1304 |
| Hacd2 | 4010 | -3297 |
| Hacd3 | 3435 | 5413 |
| Hacd4 | 5683 | 4021 |
| Hdhd5 | -6617 | -6836 |
| Hexb | 5022 | 5616 |
| Hint2 | -6923 | -6673 |
| Hmgcr | 2226 | 985 |
| Hmgcs1 | -2407 | -6353 |
| Hmgcs2 | -7290 | -6929 |
| Hpgds | 5206 | 2923 |
| Hsd11b1 | 4943 | -7273 |
| Hsd17b10 | -6937 | -7410 |
| Hsd17b11 | 1420 | -5712 |
| Hsd17b12 | 1383 | 3088 |
| Hsd17b7 | 3825 | 2098 |
| Hsd3b7 | 132 | 2489 |
| Htr2a | 3479 | 6543 |
| Idh1 | -3318 | -6643 |
| Idi1 | 1349 | -2423 |
| Igf1 | 7240 | 5920 |
| Igf1r | 6747 | 6611 |
| Igf2 | 768 | -5914 |
| Igfbp7 | 7321 | 6623 |
| Il1b | -585 | -3083 |
| Impa1 | 3413 | 3203 |
| Impa2 | -6266 | -6693 |
| Inpp1 | 2652 | 5150 |
| Inpp4b | 6154 | 6206 |
| Inppl1 | -889 | 4486 |
| Insig1 | 2500 | 2552 |
| Insig2 | 4839 | 3364 |
| Ip6k1 | 1885 | 3022 |
| Ip6k2 | 5972 | 5125 |
| Ip6k3 | -474 | -1178 |
| Isyna1 | 3652 | -667 |
| Itpkb | -6650 | -6670 |
| Itpkc | 6550 | 5648 |
| Kdsr | 2324 | 4456 |
| Lbr | -4980 | -6539 |
| Lcat | 2296 | 4654 |
| Lclat1 | 6246 | 4683 |
| Ldlr | 4127 | 4914 |
| Lias | -6337 | -6370 |
| Lpcat1 | -3107 | 1624 |
| Lpcat2 | 3656 | 4745 |
| Lpcat3 | -5695 | -6527 |
| Lpcat4 | 3445 | 1040 |
| Lpgat1 | -3466 | -2218 |
| Lpin1 | -6854 | -7150 |
| Lpin2 | 3800 | 2781 |
| Lpin3 | 5492 | 6403 |
| Lpl | -6603 | -7708 |
| Lss | 3547 | 3820 |
| Ltc4s | -2697 | -1269 |
| Mapk9 | -5584 | -6868 |
| Mboat1 | -1674 | 4442 |
| Mboat2 | 7144 | 6699 |
| Mboat7 | 3123 | -1938 |
| Mcat | -6474 | -6636 |
| Mecr | -6170 | -6438 |
| Med1 | -2830 | -5832 |
| Mgll | -4506 | -7118 |
| Mid1ip1 | -5373 | -4247 |
| Mif | 6725 | -883 |
| Mlxipl | -6339 | -6284 |
| Mlycd | -6864 | -7040 |
| Mppe1 | 1617 | 3321 |
| Msmo1 | 4477 | 3773 |
| Mtor | -3404 | -6096 |
| Mvd | -786 | 1263 |
| Mvk | -841 | 881 |
| Myo5a | 6359 | 5343 |
| Ndufab1 | -7247 | -7579 |
| Nfkb1 | 5207 | 5410 |
| Nr1d1 | 1296 | -175 |
| Nr1h2 | -243 | 1102 |
| Nr1h3 | -1853 | -4977 |
| Nr1h4 | 4445 | 220 |
| Nr3c1 | 2927 | -1142 |
| Nsdhl | 3643 | 3013 |
| Nus1 | 1719 | -1890 |
| Ormdl1 | -936 | -5023 |
| Ormdl2 | -76 | 2290 |
| Ormdl3 | 6163 | 2491 |
| Osbp | -4631 | -5804 |
| Oxsm | -3960 | -6785 |
| P2rx7 | 6389 | 6514 |
| Pam | 7404 | 6972 |
| Pbx1 | 4884 | -5143 |
| Pck1 | 1338 | 425 |
| Pck2 | 4082 | 2129 |
| Pcx | -661 | -6300 |
| Pcyt1a | -3848 | -5758 |
| Pcyt1b | 3225 | -2052 |
| Pcyt2 | -6723 | -7048 |
| Pde8b | -6620 | -7360 |
| Pdgfa | -2171 | -2809 |
| Pdgfb | -3222 | -3725 |
| Pdk4 | -1655 | 1645 |
| Pdss1 | -6299 | -6919 |
| Pdss2 | -6819 | -7474 |
| Pecr | -5886 | -6147 |
| Pemt | 1711 | 3261 |
| Pex2 | -5398 | -6265 |
| Pex5 | 5993 | 2191 |
| Pex7 | -6116 | -6538 |
| Pgap1 | -3269 | -6849 |
| Pgap2 | -6148 | -6639 |
| Pgap3 | 1059 | 1127 |
| Pgs1 | -2297 | -164 |
| Pi4k2a | 5812 | 4741 |
| Pi4k2b | 6254 | 5089 |
| Pi4ka | -4075 | -5225 |
| Pi4kb | -410 | -2942 |
| Pibf1 | 3036 | 3803 |
| Piga | -1378 | 15 |
| Pigb | 431 | -265 |
| Pigc | -3106 | -2353 |
| Pigf | -892 | 3863 |
| Pigg | -3894 | -5544 |
| Pigh | -3742 | -4955 |
| Pigk | 4908 | -2466 |
| Pigl | 1797 | 30 |
| Pigm | 2685 | 1819 |
| Pign | 3984 | 422 |
| Pigo | -6392 | -6986 |
| Pigp | -4229 | -3926 |
| Pigq | -3365 | -3974 |
| Pigs | 4429 | 1208 |
| Pigt | 4883 | -20 |
| Pigu | -4212 | -2276 |
| Pigv | -4809 | -5582 |
| Pigw | -2428 | -1307 |
| Pigx | -3211 | -3681 |
| Pigyl | -5429 | -5676 |
| Pigz | -2541 | -5070 |
| Pik3c2a | -3001 | -2146 |
| Pik3c2b | -3537 | -6207 |
| Pik3c3 | 1891 | -2240 |
| Pik3ca | 5242 | 5659 |
| Pik3cb | 3757 | 6013 |
| Pik3cd | -120 | 1463 |
| Pik3cg | 4057 | -374 |
| Pik3r1 | -7121 | -7646 |
| Pik3r2 | 7218 | 5112 |
| Pik3r3 | 5367 | 1103 |
| Pik3r4 | 480 | -3782 |
| Pip4k2a | 6260 | 5583 |
| Pip4k2b | -575 | -1112 |
| Pip4k2c | 207 | -860 |
| Pip5k1a | 6376 | 5464 |
| Pip5k1b | 3999 | -4337 |
| Pip5k1c | 3011 | 4725 |
| Pisd | -2451 | -4604 |
| Pla2g15 | 32 | -2369 |
| Pla2g3 | -2292 | 4799 |
| Pla2g4a | 7342 | 6860 |
| Pla2g5 | -6711 | -7781 |
| Pla2g6 | -1374 | -1982 |
| Plaat3 | -5135 | -6443 |
| Plce1 | -4298 | 769 |
| Plcg2 | 7267 | 6597 |
| Pld1 | 4581 | 4263 |
| Pld2 | -2706 | -947 |
| Plin5 | -6903 | -7298 |
| Plp1 | -159 | -806 |
| Plpp1 | 3994 | 6410 |
| Plscr1 | 7004 | 6226 |
| Plscr3 | 6184 | 2443 |
| Pmvk | -4994 | -4203 |
| Pnpla2 | -6697 | -6659 |
| Pnpla3 | -2880 | -773 |
| Pnpla8 | -6089 | -6606 |
| Por | 463 | -2223 |
| Ppara | -6545 | -7563 |
| Ppard | -5588 | -4490 |
| Ppargc1a | -6363 | -7511 |
| Prkaa1 | 3612 | 3708 |
| Prkaa2 | -6100 | -7414 |
| Prkab1 | -4034 | -7255 |
| Prkab2 | 7420 | 5930 |
| Prkag1 | -6213 | -4030 |
| Prkag2 | 4029 | -2192 |
| Prkag3 | 5303 | 4957 |
| Prkcd | 5903 | 6193 |
| Prmt3 | 324 | 429 |
| Prox1 | -5746 | -6481 |
| Prpf19 | -4269 | -4384 |
| Prxl2b | 2509 | -3979 |
| Ptdss1 | 4612 | 2691 |
| Ptdss2 | -4069 | -5792 |
| Ptgds | 6881 | -7629 |
| Ptges | -2486 | 1029 |
| Ptges2 | -7009 | -6869 |
| Ptges3 | -3953 | -1978 |
| Ptgis | 7197 | 6190 |
| Ptgs1 | 2392 | 1813 |
| Ptgs2 | 5209 | 6187 |
| Ptpmt1 | -4962 | -3166 |
| Pyurf | -6775 | -6970 |
| Qk | -5321 | -4839 |
| Rbp1 | 7370 | 6838 |
| Rdh10 | 1223 | -2164 |
| Rdh9 | 1841 | 3033 |
| Rest | 3977 | -1988 |
| Samd8 | 4496 | -3754 |
| Sc5d | -2682 | -5398 |
| Scap | 4774 | 3684 |
| Scarb1 | -5798 | -5138 |
| Sccpdh | -6909 | -6802 |
| Scd1 | 6517 | 6418 |
| Scd2 | 6201 | 4569 |
| Scd4 | -6898 | -6839 |
| Sco1 | -6462 | -6322 |
| Scp2 | -6736 | -7268 |
| Sdr42e1 | 1258 | -842 |
| Sec14l2 | 2467 | 2765 |
| Selenoi | -2946 | -5031 |
| Serac1 | -5070 | -5418 |
| Serinc1 | 4073 | 1017 |
| Serinc5 | -2159 | -5552 |
| Sf1 | -4575 | -4504 |
| Sgms1 | -4032 | -4342 |
| Sgms2 | 6615 | 6828 |
| Sh3glb1 | -1974 | -2693 |
| Sh3yl1 | 3848 | -535 |
| Sik1 | 6794 | 2854 |
| Sirt1 | 76 | 3596 |
| Sirt3 | -6560 | -6988 |
| Sirt4 | -5710 | -5696 |
| Slc27a1 | -6130 | -6336 |
| Slc45a3 | -749 | -1028 |
| Smg1 | -3280 | 3267 |
| Smpd1 | -6969 | -6721 |
| Smpd2 | -5709 | -5563 |
| Smpd3 | 4558 | 4699 |
| Smpd4 | -3589 | -5217 |
| Smpd5 | 1672 | -1034 |
| Snai1 | 7036 | 5217 |
| Snai2 | 1651 | 1231 |
| Socs1 | 1854 | 3043 |
| Socs2 | 2278 | 5477 |
| Socs3 | 2520 | -1464 |
| Socs4 | -1105 | -1807 |
| Socs5 | 2323 | -1732 |
| Socs6 | 2568 | 3445 |
| Socs7 | 2729 | 5086 |
| Sod1 | -6862 | -5797 |
| Sorbs1 | -5262 | -5248 |
| Sphk1 | 6933 | 6215 |
| Sphk2 | -1665 | -844 |
| Sptlc1 | 2960 | -1311 |
| Sptlc2 | 4018 | 3419 |
| Sptssa | -909 | -3305 |
| Sqle | 4439 | 3886 |
| Srd5a1 | 1673 | 1129 |
| Srd5a3 | 4993 | 3726 |
| Srebf1 | 5979 | 2962 |
| Srebf2 | 1180 | 1001 |
| St3gal1 | 3058 | 716 |
| St3gal2 | 6995 | 5852 |
| St3gal3 | -6777 | -6624 |
| St3gal4 | 4466 | -4957 |
| St6galnac3 | 48 | -5018 |
| St6galnac4 | 6331 | 6062 |
| St6galnac6 | -7184 | -7584 |
| St8sia2 | 4491 | 4888 |
| St8sia4 | -6404 | -5155 |
| St8sia6 | -1521 | -4549 |
| Star | 7459 | 7044 |
| Stard3 | -4839 | -3589 |
| Stard4 | -1094 | -3978 |
| Stk11 | -6289 | -2130 |
| Tamm41 | -2813 | -2582 |
| Tbxas1 | -921 | 2117 |
| Tcf7l2 | 1954 | -4942 |
| Tecr | -7151 | -6741 |
| Tecrl | -1100 | 5110 |
| Thnsl2 | 3309 | -4637 |
| Thrsp | -5942 | -5944 |
| Tm7sf2 | -406 | 177 |
| Tm9sf2 | -4161 | -4827 |
| Tmem150a | -4899 | -4056 |
| Tmem38b | -4685 | -3568 |
| Trex1 | 3169 | -128 |
| Trib3 | -3278 | 1445 |
| Tspo | 7491 | 6647 |
| Ttc7 | -4858 | -6775 |
| Ttc7b | -4574 | -3421 |
| Ugcg | 906 | -4712 |
| Uvrag | -98 | 4385 |
| Vac14 | 3280 | -355 |
| Vapa | 441 | -3564 |
| Wdtc1 | -6639 | -6253 |
| Wnt4 | -535 | 3355 |
| Zbtb20 | -372 | 1446 |
lipid_transport
| metric | value |
|---|---|
| setSize | 277 |
| pMANOVA | 0.295 |
| p.adjustMANOVA | 0.295 |
| s.dist | 0.0242 |
| s.young | 0.02 |
| s.old | -0.0137 |
| p.young | 0.569 |
| p.old | 0.695 |
| Gene | young | old |
|---|---|---|
| Scarb2 | 5526 | -5142 |
| Rft1 | 3829 | -5039 |
| Vmp1 | 2737 | -5158 |
| Osbpl10 | 3404 | -2455 |
| Mttp | 1233 | -6672 |
| Surf4 | 4872 | -1590 |
| Prelid2 | 3681 | -1986 |
| Ttc39b | 1835 | -3613 |
| Mif | 6725 | -883 |
| Pdzd8 | 4729 | -1124 |
| Furin | 1738 | -2954 |
| Bmp6 | 1386 | -3614 |
| C1qtnf1 | 1951 | -2348 |
| Gramd1c | 4395 | -976 |
| Ugcg | 906 | -4712 |
| Osbpl8 | 1904 | -1789 |
| Nus1 | 1719 | -1890 |
| Kiss1r | 2433 | -970 |
| Acsl3 | 2818 | -794 |
| Msr1 | 2574 | -850 |
Click HERE to show all gene set members
| young | old | |
|---|---|---|
| Abca1 | 5067 | -281 |
| Abca12 | -6269 | -7426 |
| Abca2 | -4137 | -4471 |
| Abca3 | -2208 | -1813 |
| Abca4 | -6708 | 103 |
| Abca5 | 6959 | 6732 |
| Abca6 | 6893 | 4821 |
| Abca7 | -3898 | -5481 |
| Abca8a | 7291 | 6385 |
| Abca8b | 6696 | 6368 |
| Abca9 | 7400 | 6093 |
| Abcb1a | -4791 | -6980 |
| Abcb1b | -5213 | 1574 |
| Abcb4 | 7210 | 6934 |
| Abcc1 | 6729 | 6819 |
| Abcc10 | -2038 | -1842 |
| Abcc3 | -27 | 473 |
| Abcc4 | -704 | -2753 |
| Abcd1 | -6190 | -6228 |
| Abcd2 | -5558 | -4862 |
| Abcd3 | -6653 | -7370 |
| Abcd4 | 4811 | 4646 |
| Abcg1 | 4372 | 4144 |
| Abcg2 | 4794 | 6254 |
| Acat2 | -2923 | -2278 |
| Ace | 7390 | 6602 |
| Acsl1 | -6926 | -7461 |
| Acsl3 | 2818 | -794 |
| Acsl4 | 4513 | 954 |
| Acsl5 | 3226 | 5103 |
| Acsl6 | -7255 | -7818 |
| Agt | -4320 | -6233 |
| Agtr1a | -6670 | -6883 |
| Akt1 | -6210 | -5765 |
| Akt2 | -7113 | -6780 |
| Ano4 | 6764 | 6452 |
| Ano6 | 3717 | 6048 |
| Anxa1 | 7137 | 6423 |
| Anxa2 | 6945 | 6847 |
| Apoa1 | -3117 | -370 |
| Apoa2 | -4104 | -1788 |
| Apob | -2312 | 1254 |
| Apobr | 1014 | 2281 |
| Apoc4 | -4988 | 2472 |
| Apod | 6634 | 6993 |
| Apoe | 948 | -334 |
| Aqp8 | 895 | -1646 |
| Arl8b | -2791 | -5504 |
| Arv1 | -108 | 210 |
| Atg2a | -4530 | -5147 |
| Atg2b | 81 | -2574 |
| Atg9a | -5188 | -5692 |
| Atg9b | -1538 | -2503 |
| Atp10a | 6215 | 6496 |
| Atp10d | -6372 | -2845 |
| Atp11a | 4617 | 2901 |
| Atp11b | 1403 | 110 |
| Atp11c | 223 | 175 |
| Atp5j | -7206 | -7420 |
| Atp8a1 | -3990 | -6799 |
| Atp8a2 | 6797 | 6731 |
| Atp8b1 | 5361 | 6286 |
| Atp8b2 | 6479 | 5943 |
| Atp8b4 | -4520 | 575 |
| Atp9a | 7013 | 5925 |
| Atp9b | 4301 | 5431 |
| Bmp6 | 1386 | -3614 |
| C1qtnf1 | 1951 | -2348 |
| C2cd2l | -172 | -408 |
| Cav1 | -5892 | -7143 |
| Cd36 | -5986 | -7614 |
| Ceacam1 | -7351 | -7822 |
| Ces1d | -6932 | -7808 |
| Cln3 | 778 | -186 |
| Commd1 | -5943 | -4838 |
| Cpt1b | -6751 | -7032 |
| Cptp | -650 | -1108 |
| Crot | -1116 | -3382 |
| Cry1 | -2248 | 304 |
| Cry2 | -114 | 1034 |
| Dab2 | 5377 | 3411 |
| Dbi | -6324 | -6808 |
| Dennd5b | -4417 | -4117 |
| Dgat1 | -4190 | -4756 |
| Drd2 | -1769 | 580 |
| Ecrg4 | 2904 | 5853 |
| Edn1 | 6861 | 48 |
| Eepd1 | -6325 | -6327 |
| Egf | -5607 | -6796 |
| Eprs | 5945 | 4755 |
| Esyt1 | 4773 | 5394 |
| Esyt2 | 4137 | 4086 |
| Fabp3 | -5416 | -6575 |
| Fabp4 | -2511 | -7146 |
| Fabp5 | -285 | -5130 |
| Fis1 | -3956 | -2973 |
| Furin | 1738 | -2954 |
| Fzd4 | -3807 | -5670 |
| Gltp | 3414 | 115 |
| Gm2a | 4865 | 2353 |
| Got2 | -6849 | -6590 |
| Gpihbp1 | -3847 | -6453 |
| Gps2 | -776 | 1748 |
| Gramd1a | 3761 | 1247 |
| Gramd1b | -6523 | -7392 |
| Gramd1c | 4395 | -976 |
| Gulp1 | 6088 | 4843 |
| Hbp1 | -1881 | -3772 |
| Hdlbp | -6912 | -7416 |
| Hrh2 | -2160 | -1414 |
| Igfbp3 | -4647 | -837 |
| Il1b | -585 | -3083 |
| Inhba | 7150 | 6998 |
| Irak1 | -4897 | -4749 |
| Irs2 | -2191 | 121 |
| Itgav | 7314 | 6700 |
| Itgb3 | 7496 | 5721 |
| Kcnn4 | -4302 | 298 |
| Kcnq1 | -5345 | -5178 |
| Kdm5b | 6129 | 4242 |
| Kiss1r | 2433 | -970 |
| Lamtor1 | -5263 | -4379 |
| Lbp | 4940 | 5858 |
| Lcat | 2296 | 4654 |
| Ldlr | 4127 | 4914 |
| Ldlrap1 | -211 | -1969 |
| Lima1 | 6278 | 5074 |
| Lpcat3 | -5695 | -6527 |
| Lrat | -5855 | -3045 |
| Lrp1 | 7439 | 6377 |
| Lrp10 | 6104 | 3421 |
| Lrp6 | 1802 | 1342 |
| Map2k6 | 2396 | 2679 |
| Mapk9 | -5584 | -6868 |
| Mfn2 | -6771 | -5649 |
| Mfsd2b | 2044 | 1896 |
| Mif | 6725 | -883 |
| Msr1 | 2574 | -850 |
| Mttp | 1233 | -6672 |
| Naxe | -4750 | -6089 |
| Nfkbia | 364 | 2648 |
| Nmb | -4745 | -5035 |
| Nme4 | -5156 | -6501 |
| Nos2 | -5173 | -6317 |
| Npc1 | -5117 | -6365 |
| Npc2 | 4533 | 2448 |
| Nr1h2 | -243 | 1102 |
| Nr1h3 | -1853 | -4977 |
| Nr1h4 | 4445 | 220 |
| Nrg1 | 6778 | 5305 |
| Nucb2 | 6405 | 5293 |
| Nus1 | 1719 | -1890 |
| Osbp | -4631 | -5804 |
| Osbp2 | -5752 | -7103 |
| Osbpl10 | 3404 | -2455 |
| Osbpl11 | -6004 | -6498 |
| Osbpl1a | -6498 | -7356 |
| Osbpl2 | -5898 | -6247 |
| Osbpl3 | 2824 | 4437 |
| Osbpl5 | 6889 | 6037 |
| Osbpl6 | -6391 | -7399 |
| Osbpl8 | 1904 | -1789 |
| Osbpl9 | 4590 | 3483 |
| P2rx7 | 6389 | 6514 |
| P2ry2 | 1396 | 142 |
| Pctp | -3512 | -6069 |
| Pdzd8 | 4729 | -1124 |
| Pip4k2a | 6260 | 5583 |
| Pitpna | 1284 | 2843 |
| Pitpnb | 298 | 2242 |
| Pitpnc1 | -6829 | -7733 |
| Pitpnm1 | 244 | 1871 |
| Pla2g12a | -3760 | -6921 |
| Pla2g3 | -2292 | 4799 |
| Pla2g4a | 7342 | 6860 |
| Pla2g5 | -6711 | -7781 |
| Pla2g6 | -1374 | -1982 |
| Pla2r1 | 2134 | 2981 |
| Plekha3 | 3213 | 5560 |
| Plekha8 | 611 | 1402 |
| Plin2 | -2436 | -5931 |
| Plscr1 | 7004 | 6226 |
| Plscr2 | -4473 | -699 |
| Plscr3 | 6184 | 2443 |
| Plscr4 | 5796 | 5352 |
| Plscr5 | -4774 | -6329 |
| Pltp | -6485 | -6391 |
| Pnpla8 | -6089 | -6606 |
| Pparg | -4842 | -2722 |
| Prelid1 | 6262 | 4347 |
| Prelid2 | 3681 | -1986 |
| Prelid3b | -3429 | -1023 |
| Prkcd | 5903 | 6193 |
| Proca1 | 509 | 3819 |
| Psap | -7208 | -7432 |
| Ptch1 | -1939 | -3608 |
| Ptges | -2486 | 1029 |
| Ptgs2 | 5209 | 6187 |
| Ptpn11 | -3358 | -3525 |
| Rbp1 | 7370 | 6838 |
| Rbp4 | 6701 | 6970 |
| Rbp7 | -371 | -5262 |
| Relch | 2809 | -529 |
| Repin1 | -2963 | -4078 |
| Rft1 | 3829 | -5039 |
| Rps6kb1 | -1033 | 60 |
| Runx1 | 5868 | 6372 |
| Sar1b | -6848 | -7206 |
| Scarb1 | -5798 | -5138 |
| Scarb2 | 5526 | -5142 |
| Scp2 | -6736 | -7268 |
| Sec24a | -95 | -2344 |
| Selenom | 6391 | 5515 |
| Serac1 | -5070 | -5418 |
| Sgpp1 | 5844 | 970 |
| Sigmar1 | -289 | -1895 |
| Sirt1 | 76 | 3596 |
| Slc10a3 | 6001 | 5751 |
| Slc10a6 | -3320 | -714 |
| Slc25a17 | -336 | -4956 |
| Slc25a20 | -6911 | -7554 |
| Slc27a1 | -6130 | -6336 |
| Slc27a3 | 4118 | 4704 |
| Slc27a4 | -4696 | -3130 |
| Slc27a6 | 6319 | 6142 |
| Slc2a1 | 7348 | 6876 |
| Slc4a1 | 1547 | -1146 |
| Slc51a | 1220 | 2226 |
| Slco1a4 | -3566 | -2091 |
| Slco2a1 | 5656 | 6547 |
| Slco2b1 | -3299 | -5651 |
| Slco3a1 | -1273 | -604 |
| Soat1 | 6872 | 6312 |
| Spg11 | 3332 | 5099 |
| Spns1 | -1823 | -993 |
| Spns2 | 3961 | 2023 |
| Spp1 | 4125 | 6580 |
| Srebf2 | 1180 | 1001 |
| Sstr4 | -5350 | -1133 |
| Star | 7459 | 7044 |
| Stard10 | 4205 | 2960 |
| Stard3 | -4839 | -3589 |
| Stard4 | -1094 | -3978 |
| Stard5 | -619 | -2172 |
| Stard6 | 4762 | 3926 |
| Stoml1 | 3859 | 4797 |
| Stx12 | 2261 | -613 |
| Surf4 | 4872 | -1590 |
| Syk | 7447 | 6814 |
| Syt7 | -7102 | -7695 |
| Tex2 | -5218 | -6409 |
| Thbs1 | 6742 | 6178 |
| Tmem30a | -960 | -2041 |
| Tmem41b | 4643 | 3073 |
| Tmf1 | 5476 | 2253 |
| Tnfrsf11a | 3044 | 3299 |
| Tpcn2 | 5965 | 4273 |
| Trem2 | 3242 | 3835 |
| Triap1 | -4051 | -2949 |
| Tsku | 6716 | 5417 |
| Tspo | 7491 | 6647 |
| Ttc39b | 1835 | -3613 |
| Ttpa | 248 | -5360 |
| Ugcg | 906 | -4712 |
| Vapa | 441 | -3564 |
| Vldlr | -5973 | -7766 |
| Vmp1 | 2737 | -5158 |
| Vps4a | -6836 | -7286 |
| Vps4b | 4244 | 959 |
| Vps51 | 3780 | 1101 |
| Washc1 | 2647 | 2762 |
| Xkr4 | 6478 | 5098 |
| Xkr6 | 2090 | -64 |
| Xkr8 | 1325 | 791 |
| Xrcc4 | 2600 | 1022 |
| Yjefn3 | -6265 | 257 |
| Zdhhc8 | 670 | -959 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.1.2 (2021-11-01)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.3 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] pkgload_1.2.1 GGally_2.1.2 beeswarm_0.4.0 gtools_3.9.2
## [5] echarts4r_0.4.1 mitch_1.4.0 gplots_3.1.1 reshape2_1.4.4
## [9] forcats_0.5.1 stringr_1.4.0 dplyr_1.0.7 purrr_0.3.4
## [13] readr_2.0.0 tidyr_1.1.3 tibble_3.1.3 ggplot2_3.3.5
## [17] tidyverse_1.3.1
##
## loaded via a namespace (and not attached):
## [1] bitops_1.0-7 fs_1.5.0 lubridate_1.7.10 RColorBrewer_1.1-2
## [5] httr_1.4.2 rprojroot_2.0.2 tools_4.1.2 backports_1.2.1
## [9] bslib_0.2.5.1 utf8_1.2.2 R6_2.5.0 KernSmooth_2.23-20
## [13] DBI_1.1.1 colorspace_2.0-2 withr_2.4.2 tidyselect_1.1.1
## [17] gridExtra_2.3 compiler_4.1.2 cli_3.0.1 rvest_1.0.0
## [21] xml2_1.3.2 desc_1.3.0 labeling_0.4.2 sass_0.4.0
## [25] caTools_1.18.2 scales_1.1.1 digest_0.6.27 rmarkdown_2.9
## [29] pkgconfig_2.0.3 htmltools_0.5.1.1 dbplyr_2.1.1 fastmap_1.1.0
## [33] highr_0.9 htmlwidgets_1.5.3 rlang_0.4.11 readxl_1.3.1
## [37] rstudioapi_0.13 shiny_1.6.0 jquerylib_0.1.4 generics_0.1.0
## [41] farver_2.1.0 jsonlite_1.7.2 magrittr_2.0.1 Rcpp_1.0.7
## [45] munsell_0.5.0 fansi_0.5.0 lifecycle_1.0.0 stringi_1.7.3
## [49] yaml_2.2.1 MASS_7.3-55 plyr_1.8.6 grid_4.1.2
## [53] parallel_4.1.2 promises_1.2.0.1 crayon_1.4.1 haven_2.4.1
## [57] hms_1.1.0 knitr_1.33 pillar_1.6.1 reprex_2.0.0
## [61] glue_1.4.2 evaluate_0.14 modelr_0.1.8 vctrs_0.3.8
## [65] tzdb_0.1.2 httpuv_1.6.1 cellranger_1.1.0 gtable_0.3.0
## [69] reshape_0.8.8 assertthat_0.2.1 xfun_0.24 mime_0.11
## [73] xtable_1.8-4 broom_0.7.8 later_1.2.0 ellipsis_0.3.2END of report