date generated: 2024-10-24

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610007P14Rik -0.1746777
0610009B22Rik 2.6807732
0610009E02Rik -0.4418131
0610009L18Rik 0.5270304
0610009O20Rik 2.4027199
0610010F05Rik -0.2676758

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1289
num_genes_in_profile 15245
duplicated_genes_present 0
num_profile_genes_in_sets 6763
num_profile_genes_not_in_sets 8482

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1289
num_genesets_excluded 389
num_genesets_included 900

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
ENDOSOMAL VACUOLAR PATHWAY 10 2.26e-06 -0.863 4.72e-05
PROTEIN LIPOYLATION 10 6.85e-06 0.821 1.28e-04
COMPLEX III ASSEMBLY 17 1.00e-08 0.802 3.48e-07
BRANCHED CHAIN AMINO ACID CATABOLISM 20 2.75e-09 0.768 1.07e-07
COMPLEX I BIOGENESIS 58 5.14e-24 0.766 9.26e-22
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 10 3.06e-05 0.761 4.37e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.01e-13 0.739 1.51e-11
RESPIRATORY ELECTRON TRANSPORT 124 2.20e-45 0.734 6.61e-43
CITRIC ACID CYCLE TCA CYCLE 33 6.56e-13 0.723 4.22e-11
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE 18 1.34e-07 0.718 4.30e-06
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 5.73e-05 0.701 7.73e-04
CROSSLINKING OF COLLAGEN FIBRILS 18 6.88e-07 -0.676 1.77e-05
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 14 1.21e-05 0.675 2.02e-04
MITOTIC TELOPHASE CYTOKINESIS 13 2.55e-05 -0.674 3.76e-04
MITOCHONDRIAL TRANSLATION 87 2.88e-27 0.670 6.48e-25
ESTABLISHMENT OF SISTER CHROMATID COHESION 10 3.34e-04 -0.655 3.30e-03
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT 202 8.16e-58 0.653 3.67e-55
HEME BIOSYNTHESIS 12 1.61e-04 0.629 1.84e-03
MITOCHONDRIAL PROTEIN DEGRADATION 70 9.87e-20 0.628 1.27e-17
COMPLEX IV ASSEMBLY 38 4.88e-11 0.616 2.93e-09
COHESIN LOADING ONTO CHROMATIN 10 8.86e-04 -0.607 7.13e-03
UBIQUINOL BIOSYNTHESIS 11 5.47e-04 0.602 5.07e-03
AFLATOXIN ACTIVATION AND DETOXIFICATION 10 9.84e-04 0.602 7.70e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 14 1.14e-04 0.596 1.35e-03
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 11 6.94e-04 -0.591 5.95e-03
ASPIRIN ADME 17 3.89e-05 0.576 5.39e-04
ER PHAGOSOME PATHWAY 19 2.38e-05 -0.560 3.56e-04
CHOLESTEROL BIOSYNTHESIS 26 1.74e-06 0.542 3.90e-05
NON INTEGRIN MEMBRANE ECM INTERACTIONS 30 4.18e-07 -0.534 1.14e-05
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 10 4.10e-03 0.524 2.26e-02
BIOTIN TRANSPORT AND METABOLISM 11 3.05e-03 0.516 1.79e-02
INFLAMMASOMES 12 2.09e-03 -0.513 1.36e-02
ACYL CHAIN REMODELLING OF PE 15 6.17e-04 0.511 5.49e-03
LYSINE CATABOLISM 10 5.50e-03 0.507 2.75e-02
SULFUR AMINO ACID METABOLISM 19 1.42e-04 0.504 1.66e-03
PEROXISOMAL LIPID METABOLISM 27 6.66e-06 0.501 1.28e-04
MET ACTIVATES PTK2 SIGNALING 18 4.14e-04 -0.481 3.96e-03
CHONDROITIN SULFATE BIOSYNTHESIS 16 9.57e-04 -0.477 7.55e-03
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 2.02e-03 0.477 1.33e-02
SYNDECAN INTERACTIONS 14 2.02e-03 -0.476 1.33e-02
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 30 7.30e-06 -0.473 1.34e-04
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 5.32e-06 -0.472 1.04e-04
COLLAGEN CHAIN TRIMERIZATION 34 1.93e-06 -0.472 4.24e-05
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 2.43e-03 0.468 1.51e-02
NCAM1 INTERACTIONS 16 1.28e-03 -0.465 9.62e-03
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 53 6.11e-09 -0.462 2.29e-07
MITOCHONDRIAL BIOGENESIS 10 1.25e-02 0.456 5.38e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 10 1.25e-02 0.456 5.38e-02
PEROXISOMAL PROTEIN IMPORT 61 8.93e-10 0.454 4.14e-08
CONDENSATION OF PROPHASE CHROMOSOMES 12 7.17e-03 -0.448 3.41e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
ENDOSOMAL VACUOLAR PATHWAY 10 2.26e-06 -0.863000 4.72e-05
PROTEIN LIPOYLATION 10 6.85e-06 0.821000 1.28e-04
COMPLEX III ASSEMBLY 17 1.00e-08 0.802000 3.48e-07
BRANCHED CHAIN AMINO ACID CATABOLISM 20 2.75e-09 0.768000 1.07e-07
COMPLEX I BIOGENESIS 58 5.14e-24 0.766000 9.26e-22
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 10 3.06e-05 0.761000 4.37e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.01e-13 0.739000 1.51e-11
RESPIRATORY ELECTRON TRANSPORT 124 2.20e-45 0.734000 6.61e-43
CITRIC ACID CYCLE TCA CYCLE 33 6.56e-13 0.723000 4.22e-11
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE 18 1.34e-07 0.718000 4.30e-06
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 5.73e-05 0.701000 7.73e-04
CROSSLINKING OF COLLAGEN FIBRILS 18 6.88e-07 -0.676000 1.77e-05
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 14 1.21e-05 0.675000 2.02e-04
MITOTIC TELOPHASE CYTOKINESIS 13 2.55e-05 -0.674000 3.76e-04
MITOCHONDRIAL TRANSLATION 87 2.88e-27 0.670000 6.48e-25
ESTABLISHMENT OF SISTER CHROMATID COHESION 10 3.34e-04 -0.655000 3.30e-03
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT 202 8.16e-58 0.653000 3.67e-55
HEME BIOSYNTHESIS 12 1.61e-04 0.629000 1.84e-03
MITOCHONDRIAL PROTEIN DEGRADATION 70 9.87e-20 0.628000 1.27e-17
COMPLEX IV ASSEMBLY 38 4.88e-11 0.616000 2.93e-09
COHESIN LOADING ONTO CHROMATIN 10 8.86e-04 -0.607000 7.13e-03
UBIQUINOL BIOSYNTHESIS 11 5.47e-04 0.602000 5.07e-03
AFLATOXIN ACTIVATION AND DETOXIFICATION 10 9.84e-04 0.602000 7.70e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 14 1.14e-04 0.596000 1.35e-03
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 11 6.94e-04 -0.591000 5.95e-03
ASPIRIN ADME 17 3.89e-05 0.576000 5.39e-04
ER PHAGOSOME PATHWAY 19 2.38e-05 -0.560000 3.56e-04
CHOLESTEROL BIOSYNTHESIS 26 1.74e-06 0.542000 3.90e-05
NON INTEGRIN MEMBRANE ECM INTERACTIONS 30 4.18e-07 -0.534000 1.14e-05
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 10 4.10e-03 0.524000 2.26e-02
BIOTIN TRANSPORT AND METABOLISM 11 3.05e-03 0.516000 1.79e-02
INFLAMMASOMES 12 2.09e-03 -0.513000 1.36e-02
ACYL CHAIN REMODELLING OF PE 15 6.17e-04 0.511000 5.49e-03
LYSINE CATABOLISM 10 5.50e-03 0.507000 2.75e-02
SULFUR AMINO ACID METABOLISM 19 1.42e-04 0.504000 1.66e-03
PEROXISOMAL LIPID METABOLISM 27 6.66e-06 0.501000 1.28e-04
MET ACTIVATES PTK2 SIGNALING 18 4.14e-04 -0.481000 3.96e-03
CHONDROITIN SULFATE BIOSYNTHESIS 16 9.57e-04 -0.477000 7.55e-03
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 2.02e-03 0.477000 1.33e-02
SYNDECAN INTERACTIONS 14 2.02e-03 -0.476000 1.33e-02
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 30 7.30e-06 -0.473000 1.34e-04
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 5.32e-06 -0.472000 1.04e-04
COLLAGEN CHAIN TRIMERIZATION 34 1.93e-06 -0.472000 4.24e-05
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 2.43e-03 0.468000 1.51e-02
NCAM1 INTERACTIONS 16 1.28e-03 -0.465000 9.62e-03
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 53 6.11e-09 -0.462000 2.29e-07
MITOCHONDRIAL BIOGENESIS 10 1.25e-02 0.456000 5.38e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 10 1.25e-02 0.456000 5.38e-02
PEROXISOMAL PROTEIN IMPORT 61 8.93e-10 0.454000 4.14e-08
CONDENSATION OF PROPHASE CHROMOSOMES 12 7.17e-03 -0.448000 3.41e-02
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 7.65e-03 0.445000 3.57e-02
NUCLEOTIDE BIOSYNTHESIS 12 8.15e-03 0.441000 3.74e-02
GLUTATHIONE CONJUGATION 32 1.58e-05 0.441000 2.47e-04
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 42 8.07e-07 -0.440000 2.02e-05
TRANSCRIPTIONAL REGULATION BY E2F6 23 2.60e-04 -0.440000 2.63e-03
COLLAGEN FORMATION 65 9.21e-10 -0.439000 4.14e-08
METABOLISM OF PORPHYRINS 21 5.07e-04 0.438000 4.75e-03
PRC2 METHYLATES HISTONES AND DNA 15 3.41e-03 -0.437000 1.94e-02
RUNX3 REGULATES NOTCH SIGNALING 10 1.72e-02 -0.435000 6.90e-02
RHO GTPASES ACTIVATE WASPS AND WAVES 33 2.10e-05 -0.428000 3.20e-04
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 1.59e-05 -0.428000 2.47e-04
ECM PROTEOGLYCANS 35 1.36e-05 -0.425000 2.21e-04
PECAM1 INTERACTIONS 11 1.54e-02 -0.422000 6.27e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 26 2.42e-04 -0.416000 2.51e-03
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 52 2.25e-07 -0.415000 6.87e-06
INTEGRIN CELL SURFACE INTERACTIONS 65 7.40e-09 -0.415000 2.67e-07
REGULATION OF KIT SIGNALING 12 1.30e-02 -0.414000 5.47e-02
AMINE LIGAND BINDING RECEPTORS 14 7.64e-03 0.412000 3.57e-02
FATTY ACID METABOLISM 133 3.10e-16 0.410000 3.48e-14
GLUCONEOGENESIS 19 1.99e-03 0.410000 1.33e-02
METABOLISM OF COFACTORS 23 7.14e-04 0.408000 6.06e-03
MET PROMOTES CELL MOTILITY 28 2.45e-04 -0.400000 2.51e-03
GENERATION OF SECOND MESSENGER MOLECULES 12 1.74e-02 -0.396000 6.98e-02
LAMININ INTERACTIONS 15 7.89e-03 -0.396000 3.66e-02
ACYL CHAIN REMODELLING OF PC 17 4.77e-03 0.395000 2.49e-02
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 16 6.26e-03 -0.395000 3.04e-02
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 11 2.45e-02 -0.392000 9.10e-02
TRANSLATION 218 3.14e-23 0.390000 4.70e-21
PYRUVATE METABOLISM 42 1.38e-05 0.388000 2.21e-04
HSF1 DEPENDENT TRANSACTIVATION 23 1.31e-03 0.387000 9.64e-03
POLYMERASE SWITCHING 14 1.25e-02 -0.386000 5.38e-02
DAP12 INTERACTIONS 31 2.45e-04 -0.381000 2.51e-03
LAGGING STRAND SYNTHESIS 20 3.26e-03 -0.380000 1.90e-02
ELASTIC FIBRE FORMATION 36 8.43e-05 -0.379000 1.04e-03
PROTEIN LOCALIZATION 95 1.94e-10 0.378000 1.09e-08
DNA STRAND ELONGATION 24 1.55e-03 -0.373000 1.08e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 4.15e-02 -0.372000 1.35e-01
METABOLISM OF STEROID HORMONES 15 1.28e-02 0.371000 5.43e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.36e-02 -0.368000 5.65e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH 34 2.20e-04 -0.366000 2.33e-03
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 2.35e-02 0.363000 8.86e-02
PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 10 4.77e-02 -0.362000 1.49e-01
G0 AND EARLY G1 16 1.31e-02 -0.358000 5.47e-02
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 1.82e-04 -0.356000 2.02e-03
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 11 4.19e-02 0.354000 1.36e-01
TRANSLESION SYNTHESIS BY POLK 17 1.27e-02 -0.349000 5.41e-02
LGI ADAM INTERACTIONS 10 5.61e-02 0.349000 1.67e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 10 5.68e-02 -0.348000 1.68e-01
PARACETAMOL ADME 20 7.53e-03 0.345000 3.55e-02
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 26 2.33e-03 -0.345000 1.47e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 29 1.31e-03 0.345000 9.64e-03
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 29 1.32e-03 -0.345000 9.68e-03
EXTRACELLULAR MATRIX ORGANIZATION 191 4.41e-16 -0.341000 4.41e-14
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 11 5.02e-02 0.341000 1.54e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 2.77e-02 0.340000 1.00e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 11 5.25e-02 0.338000 1.60e-01
DEADENYLATION OF MRNA 22 6.17e-03 -0.337000 3.02e-02
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 31 1.17e-03 -0.337000 8.93e-03
METABOLISM OF STEROIDS 80 2.29e-07 0.335000 6.87e-06
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 11 5.53e-02 -0.334000 1.66e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 23 5.64e-03 -0.333000 2.79e-02
TERMINATION OF TRANSLESION DNA SYNTHESIS 31 1.38e-03 -0.332000 9.94e-03
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 17 1.79e-02 -0.332000 7.08e-02
CELLULAR HEXOSE TRANSPORT 13 3.96e-02 0.330000 1.31e-01
REGULATION OF ENDOGENOUS RETROELEMENTS 28 2.79e-03 -0.327000 1.66e-02
RAC2 GTPASE CYCLE 80 4.57e-07 -0.326000 1.21e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 10 7.42e-02 -0.326000 2.01e-01
INTERFERON ALPHA BETA SIGNALING 19 1.39e-02 -0.326000 5.76e-02
FLT3 SIGNALING 26 4.56e-03 -0.321000 2.45e-02
PINK1 PRKN MEDIATED MITOPHAGY 30 2.35e-03 0.321000 1.47e-02
MITOPHAGY 37 7.39e-04 0.321000 6.11e-03
CRMPS IN SEMA3A SIGNALING 14 3.79e-02 -0.320000 1.27e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 18 1.95e-02 -0.318000 7.58e-02
DNA DAMAGE BYPASS 46 2.00e-04 -0.317000 2.19e-03
RAC3 GTPASE CYCLE 82 8.69e-07 -0.314000 2.08e-05
O LINKED GLYCOSYLATION OF MUCINS 30 2.99e-03 -0.313000 1.77e-02
COLLAGEN DEGRADATION 39 7.35e-04 -0.312000 6.11e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 15 3.80e-02 -0.309000 1.27e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 12 6.43e-02 0.309000 1.82e-01
REGULATION OF PYRUVATE METABOLISM 32 2.59e-03 0.308000 1.57e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES 187 4.64e-13 0.307000 3.21e-11
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 86 8.78e-07 0.307000 2.08e-05
MITOCHONDRIAL CALCIUM ION TRANSPORT 14 4.77e-02 0.306000 1.49e-01
OVARIAN TUMOR DOMAIN PROTEASES 31 3.36e-03 -0.304000 1.93e-02
CARNITINE METABOLISM 14 4.92e-02 0.304000 1.52e-01
METAL ION SLC TRANSPORTERS 17 3.17e-02 -0.301000 1.11e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 23 1.27e-02 -0.300000 5.41e-02
SIGNALING BY RETINOIC ACID 34 2.50e-03 0.300000 1.54e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS 24 1.16e-02 0.298000 5.10e-02
CYTOPROTECTION BY HMOX1 44 6.49e-04 0.297000 5.67e-03
RESOLUTION OF D LOOP STRUCTURES 29 5.63e-03 -0.297000 2.79e-02
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 74 1.05e-05 -0.296000 1.78e-04
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 4.73e-02 -0.296000 1.49e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 10 1.07e-01 -0.294000 2.66e-01
RHOU GTPASE CYCLE 38 1.73e-03 -0.294000 1.19e-02
REGULATION OF NF KAPPA B SIGNALING 16 4.31e-02 -0.292000 1.39e-01
TRP CHANNELS 15 5.02e-02 -0.292000 1.54e-01
RHOV GTPASE CYCLE 34 3.34e-03 -0.291000 1.93e-02
NEGATIVE REGULATION OF FLT3 13 7.10e-02 -0.289000 1.96e-01
SIGNALING BY HIPPO 20 2.52e-02 -0.289000 9.29e-02
VXPX CARGO TARGETING TO CILIUM 17 3.94e-02 -0.289000 1.31e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 30 6.33e-03 0.288000 3.04e-02
KERATAN SULFATE BIOSYNTHESIS 21 2.35e-02 -0.286000 8.86e-02
EPHB MEDIATED FORWARD SIGNALING 35 3.81e-03 -0.283000 2.14e-02
NONSENSE MEDIATED DECAY NMD INDEPENDENT OF THE EXON JUNCTION COMPLEX EJC 88 4.80e-06 0.282000 9.59e-05
SIGNALING BY BMP 23 1.92e-02 -0.282000 7.49e-02
FCGR ACTIVATION 11 1.06e-01 -0.282000 2.65e-01
VOLTAGE GATED POTASSIUM CHANNELS 21 2.54e-02 0.282000 9.32e-02
RAC1 GTPASE CYCLE 162 6.76e-10 -0.281000 3.38e-08
ISG15 ANTIVIRAL MECHANISM 27 1.16e-02 -0.281000 5.10e-02
PHASE II CONJUGATION OF COMPOUNDS 69 6.07e-05 0.279000 8.00e-04
HDR THROUGH SINGLE STRAND ANNEALING SSA 34 5.19e-03 -0.277000 2.64e-02
STRIATED MUSCLE CONTRACTION 29 9.99e-03 0.276000 4.49e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 40 2.55e-03 -0.276000 1.55e-02
FOXO MEDIATED TRANSCRIPTION 20 3.30e-02 -0.275000 1.14e-01
TELOMERE C STRAND SYNTHESIS INITIATION 11 1.14e-01 -0.275000 2.79e-01
TELOMERE MAINTENANCE 47 1.15e-03 -0.274000 8.85e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 11 1.16e-01 -0.274000 2.81e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 53 6.05e-04 -0.272000 5.44e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 15 6.81e-02 -0.272000 1.90e-01
HDR THROUGH MMEJ ALT NHEJ 12 1.03e-01 -0.272000 2.61e-01
TP53 REGULATES METABOLIC GENES 66 1.44e-04 0.271000 1.67e-03
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 14 7.98e-02 -0.270000 2.14e-01
N GLYCAN ANTENNAE ELONGATION 13 9.59e-02 -0.267000 2.47e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 14 8.46e-02 -0.266000 2.24e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 16 6.65e-02 0.265000 1.88e-01
RND3 GTPASE CYCLE 36 5.96e-03 -0.265000 2.93e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 12 1.14e-01 -0.263000 2.79e-01
RECEPTOR MEDIATED MITOPHAGY 11 1.31e-01 0.263000 3.02e-01
GLYCOGEN METABOLISM 17 6.10e-02 0.262000 1.75e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 12 1.17e-01 0.262000 2.81e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 1.18e-01 -0.261000 2.84e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 22 3.46e-02 -0.260000 1.18e-01
ENOS ACTIVATION 12 1.19e-01 -0.260000 2.85e-01
SYNTHESIS OF PA 25 2.44e-02 0.260000 9.10e-02
SIGNALING BY PDGF 50 1.49e-03 -0.260000 1.06e-02
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 29 1.59e-02 -0.259000 6.46e-02
SHC MEDIATED CASCADE FGFR3 11 1.37e-01 -0.259000 3.12e-01
METABOLISM 1435 1.19e-58 0.257000 1.07e-55
TRANSLESION SYNTHESIS BY POLH 18 5.87e-02 -0.257000 1.72e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 24 2.97e-02 -0.256000 1.05e-01
ACTIVATION OF SMO 10 1.60e-01 -0.256000 3.47e-01
MISMATCH REPAIR 14 9.83e-02 -0.255000 2.51e-01
CHROMOSOME MAINTENANCE 66 3.44e-04 -0.255000 3.36e-03
G2 M DNA DAMAGE CHECKPOINT 52 1.52e-03 -0.254000 1.07e-02
BILE ACID AND BILE SALT METABOLISM 28 1.99e-02 0.254000 7.70e-02
P75NTR SIGNALS VIA NF KB 16 7.94e-02 -0.253000 2.13e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 1.02e-01 -0.252000 2.60e-01
CDC42 GTPASE CYCLE 90 3.53e-05 -0.252000 4.97e-04
DRUG ADME 63 5.55e-04 0.252000 5.10e-03
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 17 7.33e-02 -0.251000 2.00e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 56 1.21e-03 -0.250000 9.17e-03
AMINO ACIDS REGULATE MTORC1 46 3.63e-03 0.248000 2.05e-02
PENTOSE PHOSPHATE PATHWAY 14 1.08e-01 0.248000 2.67e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 28 2.33e-02 -0.248000 8.84e-02
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.58e-01 0.246000 3.43e-01
EXTENSION OF TELOMERES 43 5.26e-03 -0.246000 2.66e-02
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 25 3.34e-02 -0.246000 1.15e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 42 6.30e-03 -0.244000 3.04e-02
HEME DEGRADATION 10 1.83e-01 0.243000 3.79e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 1.29e-01 -0.243000 2.99e-01
HOMOLOGY DIRECTED REPAIR 93 5.75e-05 -0.242000 7.73e-04
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 13 1.33e-01 0.241000 3.05e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 28 2.80e-02 -0.240000 1.01e-01
G PROTEIN BETA GAMMA SIGNALLING 27 3.19e-02 -0.239000 1.11e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 37 1.22e-02 -0.238000 5.30e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM 11 1.71e-01 -0.238000 3.62e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 20 6.75e-02 -0.236000 1.89e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 14 1.28e-01 -0.235000 2.99e-01
RHOD GTPASE CYCLE 49 4.57e-03 -0.234000 2.45e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 18 8.63e-02 -0.234000 2.28e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 16 1.06e-01 -0.233000 2.65e-01
RHOF GTPASE CYCLE 39 1.21e-02 -0.232000 5.28e-02
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 40 1.11e-02 0.232000 4.99e-02
PROCESSING OF INTRONLESS PRE MRNAS 20 7.27e-02 -0.232000 1.99e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 14 1.34e-01 -0.231000 3.07e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 25 4.67e-02 0.230000 1.48e-01
BIOLOGICAL OXIDATIONS 130 7.44e-06 0.228000 1.34e-04
INTRINSIC PATHWAY FOR APOPTOSIS 34 2.25e-02 -0.226000 8.59e-02
GPER1 SIGNALING 22 6.69e-02 -0.226000 1.89e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 1.76e-01 -0.225000 3.71e-01
RIPK1 MEDIATED REGULATED NECROSIS 29 3.59e-02 -0.225000 1.22e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 16 1.20e-01 -0.224000 2.87e-01
FATTY ACYL COA BIOSYNTHESIS 26 4.82e-02 0.224000 1.50e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 23 6.37e-02 0.223000 1.82e-01
G PROTEIN ACTIVATION 15 1.36e-01 -0.222000 3.09e-01
RHOB GTPASE CYCLE 65 1.96e-03 -0.222000 1.32e-02
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 1.83e-01 -0.222000 3.79e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 22 7.17e-02 -0.222000 1.97e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 73 1.06e-03 -0.222000 8.22e-03
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 2.04e-01 -0.221000 4.05e-01
ARACHIDONIC ACID METABOLISM 33 2.85e-02 0.220000 1.02e-01
CA DEPENDENT EVENTS 25 5.67e-02 -0.220000 1.68e-01
RHOC GTPASE CYCLE 65 2.24e-03 -0.219000 1.42e-02
MUSCLE CONTRACTION 126 2.61e-05 0.217000 3.79e-04
PI 3K CASCADE FGFR3 12 1.93e-01 -0.217000 3.95e-01
S PHASE 140 1.01e-05 -0.216000 1.75e-04
METABOLISM OF LIPIDS 463 2.08e-15 0.216000 1.70e-13
AURKA ACTIVATION BY TPX2 68 2.08e-03 -0.216000 1.35e-02
ACYL CHAIN REMODELLING OF PS 14 1.62e-01 0.216000 3.49e-01
GLUCAGON TYPE LIGAND RECEPTORS 17 1.24e-01 -0.215000 2.94e-01
GPVI MEDIATED ACTIVATION CASCADE 29 4.49e-02 -0.215000 1.43e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 2.39e-01 0.215000 4.50e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 18 1.15e-01 0.215000 2.80e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 19 1.05e-01 -0.215000 2.65e-01
ACYL CHAIN REMODELLING OF PG 10 2.40e-01 0.214000 4.50e-01
RHO GTPASES ACTIVATE KTN1 10 2.41e-01 -0.214000 4.50e-01
HDMS DEMETHYLATE HISTONES 21 8.99e-02 -0.214000 2.35e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 37 2.46e-02 -0.214000 9.11e-02
SIGNALING BY MET 61 4.24e-03 -0.212000 2.33e-02
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 72 1.96e-03 -0.211000 1.32e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 10 2.51e-01 0.210000 4.59e-01
HDACS DEACETYLATE HISTONES 29 5.13e-02 -0.209000 1.57e-01
G2 M CHECKPOINTS 121 7.61e-05 -0.208000 9.51e-04
CELL CYCLE 508 1.20e-15 -0.208000 1.08e-13
PLATELET CALCIUM HOMEOSTASIS 22 9.21e-02 -0.208000 2.39e-01
NONSENSE MEDIATED DECAY NMD 107 2.18e-04 0.207000 2.33e-03
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 15 1.67e-01 -0.206000 3.57e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 19 1.20e-01 -0.206000 2.87e-01
MISMATCH REPAIR MMR DIRECTED BY MSH2 MSH3 MUTSBETA 10 2.60e-01 -0.206000 4.68e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 126 7.11e-05 -0.205000 9.14e-04
PROTEIN HYDROXYLATION 16 1.56e-01 0.205000 3.41e-01
RHOQ GTPASE CYCLE 56 8.14e-03 -0.205000 3.74e-02
ION HOMEOSTASIS 45 1.82e-02 0.204000 7.14e-02
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 4.07e-02 -0.203000 1.34e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 92 8.03e-04 -0.202000 6.57e-03
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 11 2.46e-01 -0.202000 4.54e-01
SHC1 EVENTS IN ERBB4 SIGNALING 10 2.70e-01 -0.201000 4.81e-01
INTERLEUKIN 6 FAMILY SIGNALING 16 1.65e-01 -0.201000 3.53e-01
CARDIAC CONDUCTION 76 2.52e-03 0.201000 1.54e-02
RESOLUTION OF SISTER CHROMATID COHESION 102 4.90e-04 -0.200000 4.64e-03
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 39 3.14e-02 -0.199000 1.10e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 12 2.32e-01 -0.199000 4.44e-01
APOPTOTIC EXECUTION PHASE 42 2.56e-02 -0.199000 9.34e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 16 1.69e-01 -0.199000 3.59e-01
MITOTIC PROMETAPHASE 171 7.58e-06 -0.199000 1.34e-04
EUKARYOTIC TRANSLATION INITIATION 112 2.98e-04 0.198000 2.98e-03
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 34 4.77e-02 -0.196000 1.49e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 14 2.05e-01 -0.196000 4.05e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 79 2.71e-03 -0.195000 1.63e-02
RHO GTPASES ACTIVATE NADPH OXIDASES 18 1.52e-01 -0.195000 3.35e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 6.81e-04 -0.194000 5.89e-03
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 19 1.44e-01 -0.194000 3.22e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 19 1.45e-01 -0.193000 3.22e-01
SHC MEDIATED CASCADE FGFR2 12 2.47e-01 -0.193000 4.55e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 1.26e-01 -0.193000 2.97e-01
RHOG GTPASE CYCLE 67 6.72e-03 -0.192000 3.22e-02
PKMTS METHYLATE HISTONE LYSINES 36 4.68e-02 -0.192000 1.48e-01
PROTEIN METHYLATION 17 1.72e-01 0.191000 3.63e-01
TNFR1 INDUCED NF KAPPA B SIGNALING PATHWAY 32 6.12e-02 -0.191000 1.75e-01
CYCLIN D ASSOCIATED EVENTS IN G1 41 3.44e-02 -0.191000 1.18e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 1.05e-01 -0.191000 2.65e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 2.34e-01 0.191000 4.46e-01
PLASMA LIPOPROTEIN REMODELING 19 1.51e-01 0.190000 3.33e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 20 1.41e-01 -0.190000 3.18e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 10 2.98e-01 0.190000 5.10e-01
RHOA GTPASE CYCLE 132 1.70e-04 -0.190000 1.92e-03
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 20 1.42e-01 -0.190000 3.19e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 104 8.88e-04 0.189000 7.13e-03
RND1 GTPASE CYCLE 38 4.52e-02 -0.188000 1.44e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 11 2.82e-01 0.187000 4.92e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 1.70e-01 -0.187000 3.61e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 29 8.20e-02 -0.187000 2.19e-01
NUCLEAR SIGNALING BY ERBB4 11 2.84e-01 0.187000 4.93e-01
CELL CYCLE CHECKPOINTS 226 1.47e-06 -0.186000 3.40e-05
ELEVATION OF CYTOSOLIC CA2 LEVELS 10 3.09e-01 -0.186000 5.23e-01
DNA DOUBLE STRAND BREAK REPAIR 123 3.93e-04 -0.185000 3.81e-03
SIGNALING BY VEGF 98 1.56e-03 -0.185000 1.08e-02
SEMA3A PAK DEPENDENT AXON REPULSION 14 2.31e-01 -0.185000 4.42e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 79 4.71e-03 -0.184000 2.48e-02
G1 S TRANSITION 101 1.43e-03 -0.184000 1.02e-02
RHO GTPASE EFFECTORS 217 3.32e-06 -0.184000 6.78e-05
ACTIVATION OF BH3 ONLY PROTEINS 17 1.92e-01 -0.183000 3.92e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 10 3.17e-01 0.183000 5.31e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 18 1.80e-01 -0.183000 3.76e-01
SHC MEDIATED CASCADE FGFR4 11 2.96e-01 -0.182000 5.08e-01
NRAGE SIGNALS DEATH THROUGH JNK 49 2.78e-02 -0.182000 1.00e-01
ENDOGENOUS STEROLS 17 1.95e-01 0.181000 3.97e-01
OTHER INTERLEUKIN SIGNALING 14 2.40e-01 -0.181000 4.50e-01
SIGNALING BY TGFB FAMILY MEMBERS 105 1.34e-03 -0.181000 9.70e-03
METALLOPROTEASE DUBS 17 1.97e-01 -0.181000 3.99e-01
NETRIN 1 SIGNALING 12 2.78e-01 -0.181000 4.88e-01
METABOLISM OF VITAMINS AND COFACTORS 157 9.88e-05 0.180000 1.20e-03
REGULATED NECROSIS 45 3.65e-02 -0.180000 1.24e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 30 8.77e-02 -0.180000 2.31e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 80 5.39e-03 -0.180000 2.71e-02
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 49 2.95e-02 -0.180000 1.05e-01
GLYCOSAMINOGLYCAN METABOLISM 98 2.13e-03 -0.180000 1.37e-02
RHO GTPASE CYCLE 390 1.56e-09 -0.179000 6.69e-08
TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION 36 6.42e-02 -0.178000 1.82e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 17 2.04e-01 0.178000 4.05e-01
KERATAN SULFATE KERATIN METABOLISM 28 1.04e-01 -0.178000 2.63e-01
SIGNAL TRANSDUCTION BY L1 19 1.80e-01 -0.178000 3.76e-01
DAP12 SIGNALING 21 1.59e-01 -0.177000 3.45e-01
INTERLEUKIN 7 SIGNALING 12 2.87e-01 -0.177000 4.98e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 86 4.64e-03 -0.177000 2.46e-02
SIGNALING BY TGFBR3 21 1.63e-01 -0.176000 3.50e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 28 1.08e-01 0.175000 2.67e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 60 1.90e-02 -0.175000 7.43e-02
APOPTOSIS 89 4.34e-03 -0.175000 2.37e-02
PROLONGED ERK ACTIVATION EVENTS 13 2.75e-01 -0.175000 4.84e-01
DARPP 32 EVENTS 15 2.41e-01 0.175000 4.50e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 79 7.26e-03 0.175000 3.44e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 2.76e-01 -0.175000 4.84e-01
CD209 DC SIGN SIGNALING 16 2.28e-01 -0.174000 4.39e-01
RA BIOSYNTHESIS PATHWAY 15 2.44e-01 0.174000 4.52e-01
SIGNALING BY FGFR3 32 8.91e-02 -0.174000 2.34e-01
ONCOGENE INDUCED SENESCENCE 16 2.30e-01 -0.173000 4.41e-01
EPHRIN SIGNALING 18 2.05e-01 -0.173000 4.05e-01
SEMA4D IN SEMAPHORIN SIGNALING 15 2.47e-01 0.173000 4.55e-01
PI METABOLISM 72 1.15e-02 -0.172000 5.10e-02
EPH EPHRIN SIGNALING 57 2.55e-02 -0.171000 9.32e-02
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 3.28e-01 -0.171000 5.46e-01
AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES 79 9.11e-03 -0.170000 4.14e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 17 2.26e-01 -0.170000 4.38e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 41 6.04e-02 -0.170000 1.74e-01
SIGNALING BY SCF KIT 33 9.33e-02 -0.169000 2.41e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 14 2.78e-01 -0.168000 4.87e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 27 1.32e-01 -0.167000 3.05e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 20 1.95e-01 -0.167000 3.97e-01
ANTIGEN PROCESSING CROSS PRESENTATION 72 1.44e-02 -0.167000 5.94e-02
NICOTINAMIDE SALVAGING 15 2.65e-01 -0.166000 4.73e-01
SUMOYLATION 144 5.88e-04 -0.166000 5.34e-03
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 83 9.30e-03 -0.165000 4.20e-02
G PROTEIN MEDIATED EVENTS 36 9.16e-02 -0.163000 2.38e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.79e-01 -0.162000 3.75e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 2.11e-01 -0.162000 4.12e-01
MTOR SIGNALLING 41 7.35e-02 0.162000 2.00e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 30 1.26e-01 -0.161000 2.97e-01
DNA REPLICATION 121 2.21e-03 -0.161000 1.41e-02
PLATELET SENSITIZATION BY LDL 16 2.65e-01 0.161000 4.73e-01
PI 3K CASCADE FGFR2 13 3.20e-01 -0.159000 5.35e-01
POTASSIUM CHANNELS 56 3.93e-02 0.159000 1.31e-01
SIGNALING BY PTK6 44 6.94e-02 -0.158000 1.93e-01
RETROGRADE NEUROTROPHIN SIGNALLING 10 3.87e-01 0.158000 6.05e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 17 2.60e-01 -0.158000 4.68e-01
SMOOTH MUSCLE CONTRACTION 29 1.46e-01 0.156000 3.24e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 564 3.65e-10 -0.155000 1.93e-08
MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL 164 6.22e-04 0.155000 5.49e-03
CD28 CO STIMULATION 31 1.36e-01 -0.155000 3.09e-01
FCERI MEDIATED CA 2 MOBILIZATION 23 1.99e-01 -0.155000 4.01e-01
PROGRAMMED CELL DEATH 117 3.99e-03 -0.154000 2.21e-02
IRON UPTAKE AND TRANSPORT 46 7.15e-02 0.154000 1.97e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 33 1.27e-01 -0.154000 2.97e-01
GRB2 EVENTS IN ERBB2 SIGNALING 10 4.01e-01 -0.153000 6.14e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 3.78e-01 -0.153000 6.00e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 58 4.43e-02 0.153000 1.43e-01
RHO GTPASES ACTIVATE FORMINS 116 5.04e-03 -0.151000 2.61e-02
MACROAUTOPHAGY 119 4.58e-03 0.151000 2.45e-02
SHC MEDIATED CASCADE FGFR1 11 3.88e-01 -0.150000 6.05e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 2.22e-01 -0.150000 4.33e-01
CELL CELL COMMUNICATION 70 2.98e-02 -0.150000 1.05e-01
SYNTHESIS OF PE 10 4.12e-01 0.150000 6.23e-01
SIGNALING BY FGFR4 32 1.49e-01 -0.147000 3.30e-01
REGULATION OF FZD BY UBIQUITINATION 13 3.58e-01 -0.147000 5.87e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 2.80e-01 -0.147000 4.89e-01
SELECTIVE AUTOPHAGY 63 4.40e-02 0.147000 1.42e-01
PI 3K CASCADE FGFR4 12 3.79e-01 -0.147000 6.00e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 360 2.02e-06 -0.146000 4.32e-05
REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 32 1.52e-01 -0.146000 3.35e-01
FRS MEDIATED FGFR3 SIGNALING 13 3.62e-01 -0.146000 5.88e-01
DNA DOUBLE STRAND BREAK RESPONSE 41 1.06e-01 -0.146000 2.65e-01
FCERI MEDIATED MAPK ACTIVATION 26 2.01e-01 -0.145000 4.03e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 3.33e-01 -0.145000 5.52e-01
SURFACTANT METABOLISM 14 3.53e-01 0.143000 5.80e-01
SYNTHESIS OF PC 21 2.59e-01 0.142000 4.68e-01
ERKS ARE INACTIVATED 13 3.75e-01 -0.142000 5.99e-01
COMPLEMENT CASCADE 26 2.10e-01 0.142000 4.12e-01
DEATH RECEPTOR SIGNALING 131 5.12e-03 -0.142000 2.63e-02
PHASE I FUNCTIONALIZATION OF COMPOUNDS 56 6.82e-02 0.141000 1.90e-01
REGULATION OF PTEN GENE TRANSCRIPTION 27 2.05e-01 0.141000 4.05e-01
KERATAN SULFATE DEGRADATION 12 4.00e-01 -0.140000 6.14e-01
SHC1 EVENTS IN EGFR SIGNALING 11 4.20e-01 -0.140000 6.32e-01
SIGNALING BY ALK 14 3.64e-01 -0.140000 5.90e-01
EGFR DOWNREGULATION 28 2.00e-01 -0.140000 4.01e-01
CHROMATIN MODIFYING ENZYMES 136 5.16e-03 -0.139000 2.64e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 21 2.73e-01 -0.138000 4.84e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 66 5.46e-02 -0.137000 1.64e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 83 3.13e-02 -0.137000 1.10e-01
GAP JUNCTION DEGRADATION 11 4.33e-01 -0.136000 6.47e-01
REGULATION OF TP53 ACTIVITY 145 4.62e-03 -0.136000 2.46e-02
SIGNALING BY EGFR 43 1.23e-01 -0.136000 2.93e-01
NOD1 2 SIGNALING PATHWAY 30 1.99e-01 -0.135000 4.01e-01
MET ACTIVATES RAP1 AND RAC1 11 4.38e-01 -0.135000 6.51e-01
ORC1 REMOVAL FROM CHROMATIN 65 6.02e-02 -0.135000 1.74e-01
REPRODUCTION 11 4.40e-01 -0.134000 6.52e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 24 2.55e-01 -0.134000 4.65e-01
INSULIN RECEPTOR SIGNALLING CASCADE 33 1.84e-01 -0.134000 3.81e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 19 3.15e-01 0.133000 5.30e-01
UNFOLDED PROTEIN RESPONSE UPR 10 4.70e-01 -0.132000 6.76e-01
HYALURONAN UPTAKE AND DEGRADATION 11 4.49e-01 -0.132000 6.56e-01
POST NMDA RECEPTOR ACTIVATION EVENTS 14 3.93e-01 -0.132000 6.08e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 99 2.39e-02 -0.132000 8.95e-02
G ALPHA 12 13 SIGNALLING EVENTS 69 5.98e-02 -0.131000 1.74e-01
REGULATION OF TP53 DEGRADATION 34 1.88e-01 -0.131000 3.87e-01
MITOTIC SPINDLE CHECKPOINT 96 2.71e-02 -0.131000 9.84e-02
RHOBTB GTPASE CYCLE 34 1.91e-01 -0.130000 3.92e-01
TIE2 SIGNALING 16 3.72e-01 0.129000 5.97e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 2.96e-01 -0.129000 5.08e-01
NOTCH HLH TRANSCRIPTION PATHWAY 22 2.97e-01 -0.129000 5.09e-01
MITOTIC G2 G2 M PHASES 171 3.85e-03 -0.128000 2.15e-02
M PHASE 312 1.03e-04 -0.128000 1.23e-03
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 86 4.02e-02 -0.128000 1.33e-01
TNFR2 NON CANONICAL NF KB PATHWAY 75 5.58e-02 -0.128000 1.67e-01
RHOBTB2 GTPASE CYCLE 22 3.00e-01 -0.128000 5.11e-01
VEGFR2 MEDIATED CELL PROLIFERATION 12 4.45e-01 -0.127000 6.55e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 30 2.28e-01 0.127000 4.39e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 24 2.83e-01 0.127000 4.93e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 60 9.09e-02 -0.126000 2.37e-01
SIGNALING BY FGFR1 41 1.65e-01 -0.125000 3.53e-01
ATTENUATION PHASE 13 4.35e-01 0.125000 6.48e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 171 4.89e-03 -0.125000 2.54e-02
CELLULAR RESPONSE TO HEAT STRESS 81 5.34e-02 0.124000 1.62e-01
TRAF6 MEDIATED NF KB ACTIVATION 13 4.38e-01 -0.124000 6.51e-01
INTERFERON SIGNALING 115 2.23e-02 -0.124000 8.53e-02
KINESINS 47 1.45e-01 -0.123000 3.22e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 12 4.62e-01 -0.123000 6.67e-01
CTLA4 INHIBITORY SIGNALING 20 3.42e-01 0.123000 5.64e-01
DNA REPAIR 257 7.37e-04 -0.123000 6.11e-03
RECYCLING PATHWAY OF L1 33 2.25e-01 -0.122000 4.37e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 359 7.56e-05 -0.122000 9.51e-04
INWARDLY RECTIFYING K CHANNELS 25 2.92e-01 0.122000 5.03e-01
LYSOSOME VESICLE BIOGENESIS 30 2.50e-01 0.121000 4.59e-01
REGULATION OF TNFR1 SIGNALING 46 1.56e-01 -0.121000 3.41e-01
SIGNALING BY INTERLEUKINS 222 1.94e-03 -0.121000 1.32e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 19 3.61e-01 -0.121000 5.88e-01
FORMATION OF THE CORNIFIED ENVELOPE 17 3.89e-01 -0.121000 6.05e-01
KERATINIZATION 17 3.89e-01 -0.121000 6.05e-01
CARGO CONCENTRATION IN THE ER 29 2.63e-01 0.120000 4.72e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 11 4.96e-01 0.118000 6.99e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 14 4.45e-01 -0.118000 6.55e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 20 3.62e-01 -0.118000 5.88e-01
CELLULAR SENESCENCE 91 5.26e-02 -0.118000 1.60e-01
PI 3K CASCADE FGFR1 12 4.81e-01 -0.118000 6.85e-01
MHC CLASS II ANTIGEN PRESENTATION 98 4.47e-02 -0.117000 1.43e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 3.30e-01 -0.117000 5.50e-01
CALCINEURIN ACTIVATES NFAT 10 5.21e-01 -0.117000 7.19e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 145 1.51e-02 0.117000 6.17e-02
PEPTIDE HORMONE METABOLISM 34 2.41e-01 0.116000 4.50e-01
SIGNAL AMPLIFICATION 26 3.05e-01 -0.116000 5.16e-01
GENERIC TRANSCRIPTION PATHWAY 690 2.85e-07 -0.115000 8.00e-06
TRANSCRIPTIONAL REGULATION BY RUNX3 76 8.44e-02 -0.115000 2.24e-01
L1CAM INTERACTIONS 63 1.16e-01 -0.114000 2.81e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 4.93e-01 0.114000 6.99e-01
TOLL LIKE RECEPTOR 4 TLR4 CASCADE 112 3.70e-02 -0.114000 1.25e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 86 6.76e-02 -0.114000 1.89e-01
RAF ACTIVATION 34 2.51e-01 0.114000 4.59e-01
RND2 GTPASE CYCLE 37 2.36e-01 -0.113000 4.49e-01
CA2 PATHWAY 37 2.36e-01 -0.113000 4.49e-01
MITOTIC PROPHASE 67 1.12e-01 -0.112000 2.76e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 32 2.74e-01 -0.112000 4.84e-01
ESR MEDIATED SIGNALING 102 5.63e-02 -0.109000 1.67e-01
PLATELET AGGREGATION PLUG FORMATION 30 3.02e-01 -0.109000 5.14e-01
SIGNALING BY ACTIVIN 14 4.81e-01 0.109000 6.85e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 10 5.52e-01 -0.109000 7.40e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 3.89e-01 -0.109000 6.05e-01
DUAL INCISION IN GG NER 41 2.29e-01 -0.109000 4.41e-01
STIMULI SENSING CHANNELS 62 1.42e-01 0.108000 3.19e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 16 4.57e-01 -0.107000 6.62e-01
FGFR2 ALTERNATIVE SPLICING 17 4.44e-01 0.107000 6.55e-01
METABOLISM OF NUCLEOTIDES 77 1.04e-01 0.107000 2.64e-01
OPIOID SIGNALLING 59 1.57e-01 -0.107000 3.42e-01
GENE EXPRESSION TRANSCRIPTION 921 5.54e-08 -0.107000 1.85e-06
METHYLATION 13 5.07e-01 0.106000 7.05e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 168 1.79e-02 0.106000 7.08e-02
HS GAG BIOSYNTHESIS 21 4.01e-01 -0.106000 6.14e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 21 4.02e-01 -0.106000 6.14e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 14 4.94e-01 -0.106000 6.99e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 23 3.81e-01 0.106000 6.02e-01
REGULATION OF SIGNALING BY CBL 21 4.03e-01 -0.105000 6.14e-01
MTORC1 MEDIATED SIGNALLING 24 3.72e-01 0.105000 5.97e-01
CELL JUNCTION ORGANIZATION 59 1.63e-01 -0.105000 3.51e-01
DNA REPLICATION PRE INITIATION 97 7.46e-02 -0.105000 2.02e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 24 3.76e-01 0.104000 6.00e-01
RNA POLYMERASE I TRANSCRIPTION 41 2.52e-01 -0.103000 4.61e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 25 3.74e-01 -0.103000 5.99e-01
IMMUNE SYSTEM 1247 1.72e-09 -0.103000 7.03e-08
ERBB2 REGULATES CELL MOTILITY 12 5.40e-01 0.102000 7.34e-01
INITIAL TRIGGERING OF COMPLEMENT 13 5.24e-01 0.102000 7.20e-01
INSULIN RECEPTOR RECYCLING 24 3.88e-01 0.102000 6.05e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 12 5.42e-01 -0.102000 7.34e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 214 1.18e-02 -0.100000 5.16e-02
NERVOUS SYSTEM DEVELOPMENT 235 8.48e-03 -0.099900 3.87e-02
TGFBR3 PTM REGULATION 10 5.85e-01 -0.099700 7.68e-01
SIGNALLING TO ERKS 25 3.88e-01 -0.099700 6.05e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 89 1.07e-01 -0.099100 2.65e-01
TRIGLYCERIDE METABOLISM 12 5.53e-01 0.099000 7.40e-01
RHOJ GTPASE CYCLE 15 5.10e-01 -0.098300 7.06e-01
INTERLEUKIN 1 FAMILY SIGNALING 105 8.23e-02 -0.098200 2.19e-01
PYROPTOSIS 16 4.97e-01 -0.098100 6.99e-01
FRS MEDIATED FGFR2 SIGNALING 14 5.27e-01 -0.097700 7.20e-01
TRANSPORT OF SMALL MOLECULES 500 2.02e-04 0.097600 2.19e-03
SUMOYLATION OF RNA BINDING PROTEINS 45 2.58e-01 -0.097400 4.68e-01
BASE EXCISION REPAIR 42 2.75e-01 -0.097400 4.84e-01
GLYCOSPHINGOLIPID BIOSYNTHESIS 14 5.29e-01 0.097200 7.21e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 74 1.48e-01 -0.097200 3.29e-01
CHAPERONIN MEDIATED PROTEIN FOLDING 31 3.50e-01 -0.097000 5.76e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 11 5.79e-01 0.096700 7.62e-01
IRS MEDIATED SIGNALLING 28 3.76e-01 -0.096700 6.00e-01
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 5.98e-01 0.096400 7.74e-01
NEDDYLATION 207 1.70e-02 0.096400 6.87e-02
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 3.12e-01 -0.096100 5.27e-01
SEPARATION OF SISTER CHROMATIDS 165 3.46e-02 -0.095500 1.18e-01
PHOSPHOLIPID METABOLISM 157 4.12e-02 0.094600 1.35e-01
HEMOSTASIS 424 9.40e-04 -0.094100 7.49e-03
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 19 4.79e-01 -0.093900 6.85e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 1.34e-01 -0.093500 3.07e-01
MITOTIC METAPHASE AND ANAPHASE 202 2.23e-02 -0.093500 8.53e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 13 5.60e-01 0.093400 7.46e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 90 1.27e-01 -0.093100 2.97e-01
TOLL LIKE RECEPTOR CASCADES 138 5.94e-02 -0.093100 1.73e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 90 1.27e-01 0.093100 2.97e-01
GAP JUNCTION TRAFFICKING AND REGULATION 30 3.78e-01 -0.093000 6.00e-01
INTEGRIN SIGNALING 26 4.12e-01 -0.093000 6.23e-01
INTERFERON GAMMA SIGNALING 18 4.96e-01 -0.092800 6.99e-01
PROCESSING AND ACTIVATION OF SUMO 10 6.13e-01 -0.092400 7.84e-01
GAMMA CARBOXYLATION HYPUSINYLATION HYDROXYLATION AND ARYLSULFATASE ACTIVATION 45 2.84e-01 0.092300 4.93e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 68 1.89e-01 -0.092100 3.90e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 38 3.26e-01 -0.092000 5.45e-01
NICOTINATE METABOLISM 25 4.28e-01 -0.091600 6.40e-01
HEDGEHOG ON STATE 75 1.71e-01 -0.091600 3.62e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 51 2.61e-01 -0.091100 4.68e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 14 5.57e-01 -0.090700 7.44e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 14 5.58e-01 -0.090500 7.44e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 24 4.44e-01 -0.090300 6.55e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 21 4.80e-01 0.089100 6.85e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 93 1.39e-01 -0.088900 3.14e-01
INNATE IMMUNE SYSTEM 712 6.13e-05 -0.088800 8.00e-04
TRANSCRIPTIONAL REGULATION BY RUNX1 120 9.48e-02 -0.088400 2.45e-01
MRNA SPLICING MINOR PATHWAY 47 3.00e-01 0.087400 5.11e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 30 4.09e-01 -0.087200 6.20e-01
AGGREPHAGY 28 4.26e-01 -0.087000 6.38e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 169 5.40e-02 -0.086100 1.63e-01
RHO GTPASES ACTIVATE IQGAPS 26 4.48e-01 -0.085900 6.56e-01
REGULATED PROTEOLYSIS OF P75NTR 10 6.39e-01 0.085700 8.00e-01
GLUCOSE METABOLISM 64 2.37e-01 0.085500 4.49e-01
FANCONI ANEMIA PATHWAY 33 4.03e-01 -0.084100 6.14e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 65 2.42e-01 0.083900 4.51e-01
REGULATION OF TBK1 IKK IKBKE MEDIATED ACTIVATION OF IRF3 IRF7 14 5.89e-01 -0.083400 7.70e-01
SIGNALING BY HEDGEHOG 125 1.08e-01 -0.083400 2.67e-01
GOLGI TO ER RETROGRADE TRANSPORT 116 1.22e-01 -0.083200 2.91e-01
G ALPHA Z SIGNALLING EVENTS 27 4.57e-01 -0.082700 6.62e-01
MYD88 MAL TIRAP CASCADE INITIATED ON PLASMA MEMBRANE 81 2.00e-01 -0.082400 4.01e-01
METABOLISM OF PROTEINS 1445 2.77e-07 0.082000 8.00e-06
APC CDC20 MEDIATED DEGRADATION OF NEK2A 26 4.71e-01 -0.081800 6.76e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 4.55e-01 -0.081600 6.62e-01
SIGNALING BY NOTCH1 18 5.49e-01 -0.081600 7.39e-01
FRS MEDIATED FGFR4 SIGNALING 13 6.12e-01 -0.081300 7.84e-01
RAS PROCESSING 23 5.02e-01 0.080800 7.04e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 5.03e-01 -0.080700 7.04e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 4.18e-01 -0.080300 6.29e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 11 6.46e-01 -0.080100 8.04e-01
DEVELOPMENTAL BIOLOGY 316 1.49e-02 -0.079900 6.13e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 23 5.08e-01 -0.079800 7.05e-01
SIGNALING BY THE B CELL RECEPTOR BCR 94 1.82e-01 -0.079800 3.79e-01
RESOLUTION OF ABASIC SITES AP SITES 37 4.02e-01 -0.079700 6.14e-01
REGULATION OF RAS BY GAPS 63 2.75e-01 -0.079500 4.84e-01
GAB1 SIGNALOSOME 15 5.95e-01 -0.079300 7.74e-01
ION CHANNEL TRANSPORT 118 1.38e-01 0.079100 3.14e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 2.06e-01 -0.078900 4.06e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 22 5.26e-01 -0.078100 7.20e-01
INTRA GOLGI TRAFFIC 33 4.40e-01 -0.077800 6.52e-01
TCR SIGNALING 90 2.03e-01 -0.077700 4.05e-01
RAP1 SIGNALLING 15 6.04e-01 0.077400 7.81e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 84 2.22e-01 -0.077200 4.33e-01
HYALURONAN METABOLISM 14 6.20e-01 -0.076600 7.91e-01
SIGNALING BY ERYTHROPOIETIN 16 5.97e-01 -0.076400 7.74e-01
CS DS DEGRADATION 11 6.63e-01 -0.075800 8.16e-01
COPII MEDIATED VESICLE TRANSPORT 66 2.88e-01 0.075700 4.98e-01
MYOGENESIS 17 5.90e-01 -0.075500 7.71e-01
TNF SIGNALING 55 3.33e-01 -0.075500 5.52e-01
DEUBIQUITINATION 216 5.70e-02 -0.075300 1.68e-01
GAP JUNCTION ASSEMBLY 18 5.81e-01 -0.075300 7.64e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 5.43e-01 -0.074900 7.34e-01
TELOMERE EXTENSION BY TELOMERASE 17 5.96e-01 -0.074300 7.74e-01
RHOBTB1 GTPASE CYCLE 22 5.46e-01 -0.074300 7.37e-01
SYNAPTIC ADHESION LIKE MOLECULES 15 6.20e-01 0.073900 7.91e-01
SIGNALING BY FGFR 62 3.16e-01 -0.073700 5.30e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 4.66e-01 -0.073300 6.73e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 6.74e-01 -0.073200 8.23e-01
INOSITOL PHOSPHATE METABOLISM 42 4.13e-01 0.073000 6.24e-01
NEURONAL SYSTEM 202 7.50e-02 0.072800 2.02e-01
CD28 DEPENDENT VAV1 PATHWAY 11 6.76e-01 -0.072800 8.23e-01
ADAPTIVE IMMUNE SYSTEM 566 3.30e-03 -0.072700 1.91e-02
COSTIMULATION BY THE CD28 FAMILY 52 3.65e-01 -0.072600 5.90e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 2.59e-01 -0.072500 4.68e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 12 6.66e-01 -0.072100 8.16e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 15 6.30e-01 0.071900 7.95e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 6.95e-01 -0.071700 8.37e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 6.26e-01 -0.070400 7.94e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 110 2.08e-01 -0.069500 4.09e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 6.66e-01 -0.069200 8.16e-01
G ALPHA Q SIGNALLING EVENTS 116 1.98e-01 -0.069200 4.01e-01
INTERLEUKIN 1 SIGNALING 96 2.43e-01 -0.069100 4.51e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 254 5.89e-02 -0.069000 1.72e-01
MET RECEPTOR RECYCLING 10 7.06e-01 0.068800 8.44e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 16 6.34e-01 0.068700 7.99e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 73 3.13e-01 -0.068400 5.27e-01
CELLULAR RESPONSES TO STIMULI 420 1.79e-02 0.067600 7.08e-02
DOWNREGULATION OF ERBB2 SIGNALING 24 5.67e-01 0.067500 7.52e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 13 6.75e-01 -0.067200 8.23e-01
G ALPHA S SIGNALLING EVENTS 62 3.61e-01 -0.067100 5.88e-01
AZATHIOPRINE ADME 20 6.05e-01 0.066800 7.81e-01
TBC RABGAPS 33 5.09e-01 0.066500 7.06e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 7.19e-01 0.065700 8.52e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 12 6.95e-01 0.065400 8.37e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 56 4.00e-01 -0.065100 6.14e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.22e-01 -0.065100 8.53e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 21 6.06e-01 -0.065100 7.81e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 4.71e-01 -0.065000 6.76e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 10 7.24e-01 -0.064400 8.53e-01
PKR MEDIATED SIGNALING 60 3.89e-01 -0.064400 6.05e-01
NEUROTRANSMITTER RELEASE CYCLE 30 5.43e-01 0.064200 7.34e-01
CLATHRIN MEDIATED ENDOCYTOSIS 120 2.26e-01 -0.064100 4.38e-01
MAP2K AND MAPK ACTIVATION 36 5.07e-01 -0.063900 7.05e-01
DUAL INCISION IN TC NER 61 3.92e-01 -0.063300 6.08e-01
UCH PROTEINASES 77 3.40e-01 0.063000 5.62e-01
DEADENYLATION DEPENDENT MRNA DECAY 48 4.52e-01 -0.062800 6.59e-01
INTERLEUKIN 17 SIGNALING 57 4.16e-01 -0.062400 6.27e-01
G1 S DNA DAMAGE CHECKPOINTS 61 4.00e-01 -0.062300 6.14e-01
NEGATIVE REGULATION OF MAPK PATHWAY 41 4.92e-01 0.062000 6.99e-01
SIGNALING BY FGFR2 51 4.50e-01 -0.061200 6.58e-01
REGULATION OF BACH1 ACTIVITY 10 7.38e-01 -0.061000 8.59e-01
SHC1 EVENTS IN ERBB2 SIGNALING 13 7.04e-01 0.060900 8.42e-01
SIGNALING BY ERBB2 40 5.05e-01 -0.060900 7.05e-01
RNA POLYMERASE III TRANSCRIPTION 34 5.42e-01 0.060500 7.34e-01
RHO GTPASES ACTIVATE PAKS 22 6.26e-01 0.060100 7.94e-01
RNA POLYMERASE II PROMOTER ESCAPE 44 4.95e-01 0.059400 6.99e-01
CELLULAR RESPONSE TO HYPOXIA 65 4.08e-01 0.059400 6.20e-01
O LINKED GLYCOSYLATION 72 3.85e-01 -0.059200 6.05e-01
NUCLEAR ENVELOPE BREAKDOWN 45 4.95e-01 -0.058800 6.99e-01
NEUREXINS AND NEUROLIGINS 21 6.41e-01 0.058700 8.01e-01
TRANSCRIPTIONAL REGULATION BY TP53 274 9.62e-02 -0.058500 2.47e-01
NUCLEAR EVENTS MEDIATED BY NFE2L2 53 4.62e-01 0.058500 6.67e-01
NUCLEOTIDE EXCISION REPAIR 105 3.03e-01 -0.058300 5.14e-01
GLYCOSPHINGOLIPID METABOLISM 42 5.14e-01 0.058300 7.09e-01
ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 20 6.54e-01 0.058000 8.10e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 42 5.25e-01 -0.056700 7.20e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 36 5.61e-01 -0.056000 7.46e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 27 6.15e-01 0.056000 7.86e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 81 3.88e-01 -0.055500 6.05e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 28 6.11e-01 0.055500 7.84e-01
PURINE SALVAGE 11 7.50e-01 -0.055500 8.67e-01
FRS MEDIATED FGFR1 SIGNALING 13 7.34e-01 -0.054400 8.59e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 7.55e-01 -0.054300 8.67e-01
NEUTROPHIL DEGRANULATION 386 7.06e-02 -0.053800 1.96e-01
MITF M REGULATED MELANOCYTE DEVELOPMENT 29 6.25e-01 -0.052500 7.94e-01
INTRAFLAGELLAR TRANSPORT 40 5.69e-01 -0.052100 7.53e-01
DEGRADATION OF DVL 53 5.13e-01 0.052000 7.09e-01
DISSOLUTION OF FIBRIN CLOT 10 7.79e-01 0.051300 8.78e-01
AQUAPORIN MEDIATED TRANSPORT 25 6.58e-01 -0.051200 8.13e-01
PHOSPHORYLATION OF THE APC C 19 7.02e-01 -0.050600 8.42e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 29 6.38e-01 -0.050500 7.99e-01
BASE EXCISION REPAIR AP SITE FORMATION 15 7.35e-01 0.050500 8.59e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 14 7.45e-01 0.050300 8.63e-01
DOWNSTREAM SIGNAL TRANSDUCTION 26 6.58e-01 -0.050100 8.13e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 12 7.64e-01 -0.050100 8.74e-01
INTERLEUKIN 20 FAMILY SIGNALING 11 7.74e-01 0.050100 8.76e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 7.30e-01 -0.049900 8.58e-01
TRAFFICKING OF AMPA RECEPTORS 22 6.87e-01 0.049600 8.33e-01
SIGNALING BY GPCR 323 1.27e-01 -0.049500 2.97e-01
MRNA SPLICING 190 2.41e-01 -0.049400 4.50e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 112 3.70e-01 -0.049100 5.95e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 81 4.47e-01 -0.048900 6.56e-01
C TYPE LECTIN RECEPTORS CLRS 104 3.90e-01 -0.048800 6.06e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 32 6.35e-01 0.048500 7.99e-01
KEAP1 NFE2L2 PATHWAY 73 4.75e-01 -0.048400 6.81e-01
SIGNALING BY ROBO RECEPTORS 20 7.08e-01 -0.048300 8.45e-01
PLATELET HOMEOSTASIS 64 5.04e-01 -0.048300 7.05e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 19 7.16e-01 -0.048200 8.51e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 44 5.85e-01 -0.047700 7.68e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 6.95e-01 0.047300 8.37e-01
MITF M DEPENDENT GENE EXPRESSION 15 7.52e-01 0.047200 8.67e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK IKBKE 17 7.37e-01 -0.047100 8.59e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 130 3.60e-01 0.046600 5.88e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 26 6.82e-01 0.046500 8.28e-01
NUCLEOTIDE CATABOLISM 28 6.71e-01 0.046300 8.22e-01
SIGNALING BY NOTCH 38 6.23e-01 -0.046100 7.93e-01
ION TRANSPORT BY P TYPE ATPASES 41 6.10e-01 -0.046000 7.84e-01
MRNA CAPPING 28 6.74e-01 0.046000 8.23e-01
OTHER SEMAPHORIN INTERACTIONS 14 7.66e-01 0.045900 8.74e-01
LDL CLEARANCE 15 7.59e-01 0.045800 8.70e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 16 7.52e-01 -0.045600 8.67e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 224 2.45e-01 -0.045200 4.54e-01
TRANSCRIPTIONAL AND POST TRANSLATIONAL REGULATION OF MITF M EXPRESSION AND ACTIVITY 16 7.55e-01 -0.045000 8.67e-01
METABOLISM OF FOLATE AND PTERINES 17 7.49e-01 -0.044800 8.67e-01
RET SIGNALING 34 6.52e-01 0.044700 8.10e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 36 6.44e-01 -0.044600 8.02e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 60 5.51e-01 -0.044600 7.40e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 12 7.90e-01 0.044500 8.86e-01
ANTIMICROBIAL PEPTIDES 11 7.99e-01 0.044300 8.94e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 51 5.87e-01 0.044000 7.69e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 14 7.76e-01 0.044000 8.77e-01
HATS ACETYLATE HISTONES 29 6.84e-01 -0.043700 8.29e-01
SPRY REGULATION OF FGF SIGNALING 16 7.62e-01 -0.043700 8.73e-01
HS GAG DEGRADATION 19 7.44e-01 -0.043300 8.63e-01
SEMAPHORIN INTERACTIONS 50 5.97e-01 -0.043200 7.74e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 51 5.95e-01 -0.043100 7.74e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 73 5.26e-01 -0.042900 7.20e-01
UB SPECIFIC PROCESSING PROTEASES 151 3.64e-01 -0.042800 5.90e-01
REGULATION OF CDH11 EXPRESSION AND FUNCTION 11 8.07e-01 0.042400 8.99e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 32 6.79e-01 -0.042300 8.26e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 107 4.53e-01 0.042100 6.59e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 50 6.08e-01 0.042000 7.83e-01
SIGNALING BY NTRKS 73 5.36e-01 -0.041900 7.30e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 5.54e-01 -0.041500 7.41e-01
CLEC7A DECTIN 1 SIGNALING 88 5.02e-01 -0.041500 7.04e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 164 3.68e-01 -0.040800 5.94e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 45 6.37e-01 0.040700 7.99e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 8.29e-01 0.039500 9.09e-01
RNA POLYMERASE II PRE TRANSCRIPTION EVENTS 72 5.64e-01 -0.039300 7.49e-01
SIGNALING BY WNT 201 3.42e-01 -0.039000 5.64e-01
NUCLEOTIDE SALVAGE 19 7.70e-01 -0.038700 8.74e-01
GLYCOSPHINGOLIPID CATABOLISM 28 7.23e-01 0.038700 8.53e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 273 2.75e-01 0.038500 4.84e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 7.23e-01 0.038000 8.53e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.38e-01 -0.037300 9.12e-01
OXIDATIVE STRESS INDUCED SENESCENCE 37 6.95e-01 -0.037300 8.37e-01
GLUTAMATE AND GLUTAMINE METABOLISM 10 8.40e-01 0.036900 9.12e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 89 5.48e-01 0.036900 7.38e-01
DOWNSTREAM TCR SIGNALING 78 5.76e-01 -0.036700 7.60e-01
PCP CE PATHWAY 82 5.73e-01 -0.036100 7.57e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 15 8.10e-01 0.035900 9.00e-01
BETA CATENIN PHOSPHORYLATION CASCADE 17 8.02e-01 0.035200 8.95e-01
HEME SIGNALING 12 8.33e-01 -0.035100 9.12e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 51 6.66e-01 -0.035000 8.16e-01
FC EPSILON RECEPTOR FCERI SIGNALING 110 5.28e-01 -0.034900 7.21e-01
BASIGIN INTERACTIONS 18 7.98e-01 -0.034900 8.93e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 13 8.29e-01 0.034600 9.09e-01
TRANS GOLGI NETWORK VESICLE BUDDING 66 6.30e-01 0.034300 7.95e-01
SIGNALING BY NTRK1 TRKA 62 6.42e-01 -0.034200 8.01e-01
SIGNALING BY INSULIN RECEPTOR 56 6.61e-01 -0.033900 8.15e-01
VESICLE MEDIATED TRANSPORT 522 1.90e-01 -0.033700 3.90e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 40 7.16e-01 -0.033300 8.51e-01
VLDLR INTERNALISATION AND DEGRADATION 15 8.24e-01 0.033300 9.07e-01
INTERLEUKIN 2 FAMILY SIGNALING 26 7.71e-01 -0.032900 8.74e-01
MAPK6 MAPK4 SIGNALING 70 6.35e-01 -0.032900 7.99e-01
SNRNP ASSEMBLY 47 7.01e-01 0.032300 8.42e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 26 7.77e-01 -0.032100 8.78e-01
REGULATION OF INSULIN SECRETION 49 6.98e-01 -0.032000 8.39e-01
DEPOLYMERIZATION OF THE NUCLEAR LAMINA 11 8.54e-01 -0.032000 9.16e-01
CELL CELL JUNCTION ORGANIZATION 37 7.36e-01 -0.032000 8.59e-01
ADHERENS JUNCTIONS INTERACTIONS 29 7.70e-01 -0.031300 8.74e-01
ACTIVATION OF APC C AND APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 72 6.51e-01 -0.030900 8.09e-01
FORMATION OF TC NER PRE INCISION COMPLEX 49 7.12e-01 0.030500 8.48e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 8.41e-01 -0.029000 9.12e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 62 6.96e-01 0.028700 8.37e-01
MAPK FAMILY SIGNALING CASCADES 258 4.28e-01 -0.028700 6.40e-01
INACTIVATION OF CSF3 G CSF SIGNALING 15 8.49e-01 0.028500 9.16e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 17 8.41e-01 0.028100 9.12e-01
HEDGEHOG OFF STATE 100 6.29e-01 -0.028000 7.95e-01
SIGNALING BY NOTCH3 19 8.34e-01 0.027800 9.12e-01
RMTS METHYLATE HISTONE ARGININES 25 8.10e-01 -0.027800 9.00e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 34 7.80e-01 0.027700 8.78e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 28 8.05e-01 0.027000 8.98e-01
METABOLISM OF POLYAMINES 54 7.32e-01 0.026900 8.59e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 13 8.70e-01 -0.026200 9.28e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 61 7.27e-01 -0.025800 8.55e-01
ACTIVATION OF NF KAPPAB IN B CELLS 59 7.38e-01 -0.025200 8.59e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 12 8.81e-01 0.024900 9.30e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 7.55e-01 0.024800 8.67e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 8.38e-01 0.024600 9.12e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 14 8.75e-01 0.024300 9.29e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 11 8.89e-01 0.024200 9.35e-01
PI3K EVENTS IN ERBB2 SIGNALING 13 8.80e-01 0.024200 9.30e-01
PEXOPHAGY 10 8.96e-01 -0.023800 9.39e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 20 8.54e-01 0.023800 9.16e-01
RHOH GTPASE CYCLE 31 8.20e-01 -0.023600 9.05e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 15 8.78e-01 0.022900 9.30e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 135 6.56e-01 -0.022200 8.12e-01
INTEGRATION OF ENERGY METABOLISM 59 7.68e-01 -0.022200 8.74e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 7.87e-01 -0.021500 8.84e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 9.07e-01 -0.021400 9.47e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 75 7.52e-01 0.021100 8.67e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1089 2.60e-01 -0.020500 4.68e-01
FCERI MEDIATED NF KB ACTIVATION 70 7.69e-01 0.020400 8.74e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND 46 8.13e-01 -0.020200 9.00e-01
RAB REGULATION OF TRAFFICKING 109 7.18e-01 -0.020000 8.52e-01
PEPTIDE LIGAND BINDING RECEPTORS 57 7.94e-01 0.020000 8.90e-01
SIGNALING BY ERBB4 32 8.50e-01 0.019400 9.16e-01
GROWTH HORMONE RECEPTOR SIGNALING 10 9.16e-01 0.019300 9.53e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 27 8.64e-01 0.019100 9.25e-01
PURINE CATABOLISM 16 8.98e-01 0.018500 9.40e-01
HEDGEHOG LIGAND BIOGENESIS 56 8.12e-01 -0.018400 9.00e-01
UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 49 8.24e-01 0.018400 9.07e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 139 7.09e-01 -0.018300 8.45e-01
SIGNALLING TO RAS 12 9.15e-01 -0.017800 9.53e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 59 8.15e-01 -0.017600 9.00e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 8.42e-01 -0.017500 9.12e-01
EFFECTS OF PIP2 HYDROLYSIS 22 8.87e-01 -0.017500 9.35e-01
PLASMA LIPOPROTEIN CLEARANCE 28 8.73e-01 0.017400 9.29e-01
GENE SILENCING BY RNA 40 8.49e-01 -0.017400 9.16e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 31 8.68e-01 -0.017300 9.27e-01
PTEN REGULATION 95 7.71e-01 0.017300 8.74e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 23 8.88e-01 -0.017000 9.35e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 41 8.53e-01 -0.016800 9.16e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 54 8.37e-01 0.016200 9.12e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 30 8.80e-01 0.016000 9.30e-01
GABA RECEPTOR ACTIVATION 37 8.71e-01 -0.015400 9.28e-01
INTERLEUKIN 15 SIGNALING 10 9.35e-01 -0.014900 9.66e-01
SENSORY PERCEPTION 56 8.54e-01 0.014300 9.16e-01
G ALPHA I SIGNALLING EVENTS 129 7.80e-01 -0.014200 8.78e-01
GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME 54 8.70e-01 0.012900 9.28e-01
DNA DAMAGE RECOGNITION IN GG NER 38 8.92e-01 0.012800 9.36e-01
NUCLEAR ENVELOPE NE REASSEMBLY 61 8.64e-01 -0.012700 9.25e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 81 8.45e-01 -0.012600 9.14e-01
INTERACTION BETWEEN L1 AND ANKYRINS 10 9.47e-01 -0.012200 9.70e-01
DEGRADATION OF AXIN 52 8.79e-01 -0.012200 9.30e-01
GPCR LIGAND BINDING 139 8.13e-01 -0.011700 9.00e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 12 9.45e-01 -0.011400 9.70e-01
SIGNALING BY NUCLEAR RECEPTORS 144 8.14e-01 -0.011400 9.00e-01
JOSEPHIN DOMAIN DUBS 10 9.51e-01 -0.011300 9.70e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 314 7.33e-01 -0.011200 8.59e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 49 8.93e-01 -0.011100 9.36e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 8.78e-01 -0.010900 9.30e-01
ESTROGEN DEPENDENT GENE EXPRESSION 43 9.12e-01 0.009730 9.51e-01
METABOLISM OF FAT SOLUBLE VITAMINS 31 9.26e-01 -0.009680 9.61e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 22 9.39e-01 -0.009500 9.68e-01
THE PHOTOTRANSDUCTION CASCADE 17 9.47e-01 -0.009290 9.70e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 18 9.46e-01 -0.009170 9.70e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 28 9.34e-01 -0.009060 9.66e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 45 9.20e-01 0.008680 9.56e-01
METABOLISM OF CARBOHYDRATES 219 8.42e-01 0.007860 9.12e-01
GABA B RECEPTOR ACTIVATION 33 9.38e-01 0.007860 9.68e-01
ERK MAPK TARGETS 19 9.53e-01 0.007850 9.70e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 10 9.67e-01 0.007440 9.79e-01
SIALIC ACID METABOLISM 25 9.50e-01 0.007320 9.70e-01
VISUAL PHOTOTRANSDUCTION 51 9.30e-01 0.007160 9.63e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 54 9.30e-01 0.006900 9.63e-01
FORMATION OF WDR5 CONTAINING HISTONE MODIFYING COMPLEXES 36 9.44e-01 0.006770 9.70e-01
RHO GTPASES ACTIVATE PKNS 21 9.58e-01 0.006620 9.72e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 9.60e-01 -0.005740 9.73e-01
NONHOMOLOGOUS END JOINING NHEJ 31 9.58e-01 0.005500 9.72e-01
METABOLISM OF RNA 559 8.25e-01 -0.005500 9.07e-01
STABILIZATION OF P53 52 9.48e-01 -0.005200 9.70e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 9.73e-01 0.004960 9.81e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 12 9.77e-01 0.004750 9.84e-01
SIGNALING BY CSF3 G CSF 19 9.73e-01 0.004520 9.81e-01
ASPARAGINE N LINKED GLYCOSYLATION 241 9.07e-01 0.004390 9.47e-01
CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 69 9.50e-01 -0.004360 9.70e-01
RAB GERANYLGERANYLATION 52 9.58e-01 -0.004270 9.72e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 71 9.52e-01 0.004180 9.70e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 18 9.80e-01 0.003460 9.85e-01
PROTEIN UBIQUITINATION 56 9.73e-01 -0.002630 9.81e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 68 9.71e-01 0.002560 9.81e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 9.92e-01 0.001610 9.95e-01
SPHINGOLIPID METABOLISM 72 9.83e-01 0.001480 9.87e-01
IRAK1 RECRUITS IKK COMPLEX 14 9.93e-01 -0.001370 9.95e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 13 9.95e-01 0.001080 9.96e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 82 9.98e-01 0.000127 9.98e-01


Detailed Gene set reports



ENDOSOMAL VACUOLAR PATHWAY
set ENDOSOMAL VACUOLAR PATHWAY
setSize 10
pANOVA 2.26e-06
s.dist -0.863
p.adjustANOVA 4.72e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2-Q6 -7424
H2-Q7 -7417
B2m -7409
H2-T22 -7408
H2-K1 -7407
H2-Q4 -7396
H2-T23 -7168
H2-M3 -6202
H2-T10 -5883
Lnpep -129

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2-Q6 -7424
H2-Q7 -7417
B2m -7409
H2-T22 -7408
H2-K1 -7407
H2-Q4 -7396
H2-T23 -7168
H2-M3 -6202
H2-T10 -5883
Lnpep -129


PROTEIN LIPOYLATION
set PROTEIN LIPOYLATION
setSize 10
pANOVA 6.85e-06
s.dist 0.821
p.adjustANOVA 0.000128


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufab1 7795
Dlat 7734
Dlst 7607
Dbt 7077
Lipt2 6936
Lias 6695
Gcsh 6168
Fdx1 6090
Lipt1 4772
Nfu1 3621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufab1 7795
Dlat 7734
Dlst 7607
Dbt 7077
Lipt2 6936
Lias 6695
Gcsh 6168
Fdx1 6090
Lipt1 4772
Nfu1 3621


COMPLEX III ASSEMBLY
set COMPLEX III ASSEMBLY
setSize 17
pANOVA 1e-08
s.dist 0.802
p.adjustANOVA 3.48e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Uqcrc2 7441
Hspa9 7433
Uqcrh 7305
Lyrm7 7272
Lyrm4 7182
Uqcrfs1 7145
Cyc1 6957
Nfs1 6950
Uqcrq 6935
Iscu 6727
Uqcrc1 6703
Uqcrb 6620
mt-Cytb 5778
Uqcr10 5424
Ttc19 4223
Fxn 3804
Hscb 3248

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Uqcrc2 7441
Hspa9 7433
Uqcrh 7305
Lyrm7 7272
Lyrm4 7182
Uqcrfs1 7145
Cyc1 6957
Nfs1 6950
Uqcrq 6935
Iscu 6727
Uqcrc1 6703
Uqcrb 6620
mt-Cytb 5778
Uqcr10 5424
Ttc19 4223
Fxn 3804
Hscb 3248


BRANCHED CHAIN AMINO ACID CATABOLISM
set BRANCHED CHAIN AMINO ACID CATABOLISM
setSize 20
pANOVA 2.75e-09
s.dist 0.768
p.adjustANOVA 1.07e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hibadh 7698
Mccc2 7683
Bckdhb 7628
Aldh6a1 7544
Acat1 7394
Echs1 7365
Hsd17b10 7282
Ivd 7279
Bcat2 7248
Mccc1 7167
Dbt 7077
Auh 6944
Hibch 6796
Ppm1k 6473
Acadsb 5315
Bckdha 5097
Bckdk 4884
Dld 3955
Acad8 1682
Bcat1 -1759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hibadh 7698
Mccc2 7683
Bckdhb 7628
Aldh6a1 7544
Acat1 7394
Echs1 7365
Hsd17b10 7282
Ivd 7279
Bcat2 7248
Mccc1 7167
Dbt 7077
Auh 6944
Hibch 6796
Ppm1k 6473
Acadsb 5315
Bckdha 5097
Bckdk 4884
Dld 3955
Acad8 1682
Bcat1 -1759


COMPLEX I BIOGENESIS
set COMPLEX I BIOGENESIS
setSize 58
pANOVA 5.14e-24
s.dist 0.766
p.adjustANOVA 9.26e-22


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufab1 7795
mt-Nd6 7753
Ndufv2 7671
Ndufc2 7618
Ndufa5 7598
Ndufa6 7568
Ndufs3 7485
Ndufa12 7479
Hspa9 7433
Ndufa3 7391
Ndufc1 7364
Ndufa9 7325
Ndufs4 7323
Ndufs2 7313
Ndufb8 7300
Timmdc1 7284
Ndufv3 7277
Ndufs1 7271
Ndufa13 7147
Ndufb11 7141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufab1 7795
mt-Nd6 7753
Ndufv2 7671
Ndufc2 7618
Ndufa5 7598
Ndufa6 7568
Ndufs3 7485
Ndufa12 7479
Hspa9 7433
Ndufa3 7391
Ndufc1 7364
Ndufa9 7325
Ndufs4 7323
Ndufs2 7313
Ndufb8 7300
Timmdc1 7284
Ndufv3 7277
Ndufs1 7271
Ndufa13 7147
Ndufb11 7141
Ndufb9 7100
Ndufs6 7038
Ndufs8 6993
Ndufaf3 6988
Ndufb5 6842
Ndufb10 6806
Ndufb3 6767
Ecsit 6750
Ndufs7 6749
Ndufa10 6701
Ndufa7 6533
Acad9 6468
Ndufa8 6448
Ndufa1 6200
Ndufaf4 5800
Ndufb6 5799
Ndufb4 5756
Ndufv1 5612
Ndufaf6 5517
Ndufa11 5296
Ndufs5 5100
mt-Nd5 5023
Lyrm2 4990
Ndufb7 4947
Ndufaf7 4809
mt-Nd1 4753
Ndufa2 4733
Ndufaf2 4693
Ndufaf1 4589
mt-Nd4 4527
Ndufaf5 4473
Tmem186 4437
Nubpl 4394
mt-Nd2 4128
Hscb 3248
Tmem126b 3220
Ndufb2 3010
Pyurf -3016


MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
set MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
setSize 10
pANOVA 3.06e-05
s.dist 0.761
p.adjustANOVA 0.000437


Top enriched genes
Top 20 genes
GeneID Gene Rank
Isca2 7749
Isca1 7203
Lyrm4 7182
Nfs1 6950
Iscu 6727
Glrx5 6118
Fdx1 6090
Fdxr 4844
Fxn 3804
Hscb 3248

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Isca2 7749
Isca1 7203
Lyrm4 7182
Nfs1 6950
Iscu 6727
Glrx5 6118
Fdx1 6090
Fdxr 4844
Fxn 3804
Hscb 3248


MITOCHONDRIAL FATTY ACID BETA OXIDATION
set MITOCHONDRIAL FATTY ACID BETA OXIDATION
setSize 33
pANOVA 2.01e-13
s.dist 0.739
p.adjustANOVA 1.51e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufab1 7795
Acaa2 7776
Acot11 7748
Acot1 7716
Decr1 7676
Mcee 7629
Acadl 7571
Acad11 7542
Acadvl 7533
Eci1 7431
Hadh 7375
Echs1 7365
Dbi 7340
Acot13 7260
Acot2 7256
Acad10 7244
Mecr 7243
Hadha 7199
Mmaa 7123
Acadm 6761

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufab1 7795
Acaa2 7776
Acot11 7748
Acot1 7716
Decr1 7676
Mcee 7629
Acadl 7571
Acad11 7542
Acadvl 7533
Eci1 7431
Hadh 7375
Echs1 7365
Dbi 7340
Acot13 7260
Acot2 7256
Acad10 7244
Mecr 7243
Hadha 7199
Mmaa 7123
Acadm 6761
Acads 6702
Hadhb 6673
Pcca 6554
Acsf2 6454
Mcat 5398
Pctp 3922
Acot7 3484
Acot12 3397
Acbd6 3326
Pccb 2577
Acot3 1109
Acot9 -2957
Them4 -3435


RESPIRATORY ELECTRON TRANSPORT
set RESPIRATORY ELECTRON TRANSPORT
setSize 124
pANOVA 2.2e-45
s.dist 0.734
p.adjustANOVA 6.61e-43


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufab1 7795
Cox5a 7763
mt-Nd6 7753
Cox7a1 7707
Ndufv2 7671
Got1 7659
Ndufc2 7618
Ndufa5 7598
Ndufa6 7568
Etfdh 7551
Etfa 7536
Ndufs3 7485
Ndufa12 7479
Uqcrc2 7441
Hspa9 7433
Mdh1 7413
Ndufa3 7391
Etfb 7388
Ndufc1 7364
Slc25a11 7339

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufab1 7795
Cox5a 7763
mt-Nd6 7753
Cox7a1 7707
Ndufv2 7671
Got1 7659
Ndufc2 7618
Ndufa5 7598
Ndufa6 7568
Etfdh 7551
Etfa 7536
Ndufs3 7485
Ndufa12 7479
Uqcrc2 7441
Hspa9 7433
Mdh1 7413
Ndufa3 7391
Etfb 7388
Ndufc1 7364
Slc25a11 7339
Coa5 7335
Ndufa9 7325
Ndufs4 7323
Ndufs2 7313
Coq10a 7308
Uqcrh 7305
Ndufb8 7300
Timmdc1 7284
Ndufv3 7277
Lyrm7 7272
Ndufs1 7271
Ndufa4 7259
Lyrm4 7182
Cox11 7179
Ndufa13 7147
Uqcrfs1 7145
Ndufb11 7141
Ndufb9 7100
Cox5b 7063
Ndufs6 7038
Ndufs8 6993
Ndufaf3 6988
Cox6a2 6971
Cyc1 6957
Nfs1 6950
Uqcrq 6935
Cox4i1 6927
Coa3 6848
Ndufb5 6842
Ndufb10 6806
Cox7a2 6780
Ndufb3 6767
Tmem177 6754
Ecsit 6750
Ndufs7 6749
Cox6c 6748
Iscu 6727
Cox7c 6726
Uqcrc1 6703
Ndufa10 6701
Cycs 6637
Uqcrb 6620
Slc25a12 6617
Cox6b1 6566
Ndufa7 6533
Acad9 6468
Ndufa8 6448
Smim20 6396
Cox19 6395
Cox7a2l 6385
Cox6b2 6234
Ndufa1 6200
Mdh2 5846
Ndufaf4 5800
Ndufb6 5799
mt-Cytb 5778
Ndufb4 5756
Got2 5656
Cox18 5641
Slc25a22 5634
Ndufv1 5612
Cox20 5609
Ndufaf6 5517
Cox6a1 5470
Uqcr10 5424
Ndufa11 5296
Higd1a 5218
Cox14 5188
Ndufs5 5100
mt-Nd5 5023
Cox7b 5006
Lyrm2 4990
Sco1 4955
Ndufb7 4947
Ndufaf7 4809
mt-Nd1 4753
Ndufa2 4733
Ndufaf2 4693
Ndufaf1 4589
mt-Nd4 4527
Cox4i2 4474
Ndufaf5 4473
Tmem186 4437
Nubpl 4394
Ttc19 4223
mt-Nd2 4128
Timm21 4021
Cox15 3896
Fxn 3804
Hccs 3299
Hscb 3248
Tmem126b 3220
Ndufb2 3010
mt-Co1 2990
Higd2a 2837
Surf1 2712
Slc25a13 2617
Cox8a 2548
Sco2 2341
Cmc1 2058
Cox16 -1138
Cox17 -2893
Pyurf -3016
Coq10b -6920


CITRIC ACID CYCLE TCA CYCLE
set CITRIC ACID CYCLE TCA CYCLE
setSize 33
pANOVA 6.56e-13
s.dist 0.723
p.adjustANOVA 4.22e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
Suclg1 7756
Sdha 7752
Isca2 7749
Sdhc 7674
Dlst 7607
Idh3b 7521
Idh3a 7496
Acat1 7394
Nnt 7212
Sdhb 7210
Isca1 7203
Lyrm4 7182
Cs 7139
Sdhd 7099
Fh1 7090
Nfs1 6950
Sirt3 6919
Iscu 6727
Idh3g 6575
Sdhaf4 6482

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Suclg1 7756
Sdha 7752
Isca2 7749
Sdhc 7674
Dlst 7607
Idh3b 7521
Idh3a 7496
Acat1 7394
Nnt 7212
Sdhb 7210
Isca1 7203
Lyrm4 7182
Cs 7139
Sdhd 7099
Fh1 7090
Nfs1 6950
Sirt3 6919
Iscu 6727
Idh3g 6575
Sdhaf4 6482
Mdh2 5846
Suclg2 5754
Mrps36 5081
Ogdh 4780
Sdhaf3 4556
Dld 3955
Fxn 3804
Sdhaf1 3263
Trap1 3221
Aco2 2934
Sdhaf2 538
Idh2 410
Sucla2 -1120


MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE
set MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE
setSize 18
pANOVA 1.34e-07
s.dist 0.718
p.adjustANOVA 4.3e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sdha 7752
Isca2 7749
Sdhc 7674
Acat1 7394
Sdhb 7210
Isca1 7203
Lyrm4 7182
Sdhd 7099
Nfs1 6950
Sirt3 6919
Iscu 6727
Sdhaf4 6482
Sdhaf3 4556
Fxn 3804
Sdhaf1 3263
Aco2 2934
Sdhaf2 538
Idh2 410

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sdha 7752
Isca2 7749
Sdhc 7674
Acat1 7394
Sdhb 7210
Isca1 7203
Lyrm4 7182
Sdhd 7099
Nfs1 6950
Sirt3 6919
Iscu 6727
Sdhaf4 6482
Sdhaf3 4556
Fxn 3804
Sdhaf1 3263
Aco2 2934
Sdhaf2 538
Idh2 410


BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS
set BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS
setSize 11
pANOVA 5.73e-05
s.dist 0.701
p.adjustANOVA 0.000773


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hsd17b4 7386
Mlycd 7253
Acot4 6979
Abcd1 6524
Acox1 6296
Decr2 6052
Eci2 5688
Acot6 5103
Acaa1b 5040
Acot8 2283
Ehhadh 2218

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsd17b4 7386
Mlycd 7253
Acot4 6979
Abcd1 6524
Acox1 6296
Decr2 6052
Eci2 5688
Acot6 5103
Acaa1b 5040
Acot8 2283
Ehhadh 2218


CROSSLINKING OF COLLAGEN FIBRILS
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 18
pANOVA 6.88e-07
s.dist -0.676
p.adjustANOVA 1.77e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Loxl2 -7363
Col4a3 -7227
Pxdn -7124
Loxl4 -7054
Col4a4 -7015
Col1a2 -6884
Col4a2 -6504
Loxl3 -6495
Lox -6132
Tll2 -6099
Col4a1 -6011
Col1a1 -5269
Pcolce -4622
Col4a5 -4615
Tll1 -4233
Bmp1 -2394
Loxl1 -1109
Col4a6 7012

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Loxl2 -7363
Col4a3 -7227
Pxdn -7124
Loxl4 -7054
Col4a4 -7015
Col1a2 -6884
Col4a2 -6504
Loxl3 -6495
Lox -6132
Tll2 -6099
Col4a1 -6011
Col1a1 -5269
Pcolce -4622
Col4a5 -4615
Tll1 -4233
Bmp1 -2394
Loxl1 -1109
Col4a6 7012


GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION
set GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION
setSize 14
pANOVA 1.21e-05
s.dist 0.675
p.adjustANOVA 0.000202


Top enriched genes
Top 20 genes
GeneID Gene Rank
Aldh4a1 7625
Dlst 7607
Gnmt 7214
Ddo 6984
Gcsh 6168
Dao 5894
Got2 5656
Hoga1 5099
Mrps36 5081
Ogdh 4780
Amt 4235
Dld 3955
Gldc 3637
Grhpr 757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aldh4a1 7625
Dlst 7607
Gnmt 7214
Ddo 6984
Gcsh 6168
Dao 5894
Got2 5656
Hoga1 5099
Mrps36 5081
Ogdh 4780
Amt 4235
Dld 3955
Gldc 3637
Grhpr 757


MITOTIC TELOPHASE CYTOKINESIS
set MITOTIC TELOPHASE CYTOKINESIS
setSize 13
pANOVA 2.55e-05
s.dist -0.674
p.adjustANOVA 0.000376


Top enriched genes
Top 20 genes
GeneID Gene Rank
Kif20a -6896
Plk1 -6765
Kif23 -6286
Wapl -5743
Pds5b -5315
Pds5a -4975
Stag1 -4854
Nipbl -4813
Rad21 -4409
Stag2 -3987
Smc1a -3841
Mau2 -3457
Smc3 -2920

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kif20a -6896
Plk1 -6765
Kif23 -6286
Wapl -5743
Pds5b -5315
Pds5a -4975
Stag1 -4854
Nipbl -4813
Rad21 -4409
Stag2 -3987
Smc1a -3841
Mau2 -3457
Smc3 -2920


MITOCHONDRIAL TRANSLATION
set MITOCHONDRIAL TRANSLATION
setSize 87
pANOVA 2.88e-27
s.dist 0.67
p.adjustANOVA 6.48e-25


Top enriched genes
Top 20 genes
GeneID Gene Rank
Oxa1l 7627
Mrpl39 7546
Mrpl41 7492
Mrpl45 7466
Gfm2 7392
Chchd1 7336
Dap3 7287
Mrpl30 7262
Mrpl46 7128
Mrpl21 7102
Mrpl12 7089
Mrps10 7078
Mrpl33 6931
Mrps27 6922
Mrpl35 6914
Mrps35 6907
Mrpl51 6906
Mrpl42 6857
Mrps15 6779
Mrps14 6766

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Oxa1l 7627
Mrpl39 7546
Mrpl41 7492
Mrpl45 7466
Gfm2 7392
Chchd1 7336
Dap3 7287
Mrpl30 7262
Mrpl46 7128
Mrpl21 7102
Mrpl12 7089
Mrps10 7078
Mrpl33 6931
Mrps27 6922
Mrpl35 6914
Mrps35 6907
Mrpl51 6906
Mrpl42 6857
Mrps15 6779
Mrps14 6766
Mrpl19 6718
Mrpl11 6691
Mrpl43 6616
Mrpl14 6562
Mrpl15 6530
Aurkaip1 6525
Mrpl36 6522
Mrpl44 6442
Mrps28 6332
Mrpl34 6261
Mrpl55 6206
Gfm1 6201
Mrpl18 6196
Mrps12 6190
Mrpl37 6187
Mrps18b 6186
Mrps2 6179
Mrps21 6177
Mrps34 6170
Mrpl20 6164
Mrpl47 6142
Mrpl52 6071
Mrpl49 6066
Mrpl48 6035
Mrps24 5934
Mrpl27 5899
Eral1 5892
Mrps23 5839
Gadd45gip1 5795
Mrpl4 5727
Mrpl17 5581
Mrpl3 5561
Mrps16 5528
Mrpl38 5404
Mrps18a 5334
Mrpl54 5316
Mrpl2 5262
Mrpl40 5183
Mrpl13 5160
Mrpl28 5123
Mrps36 5081
Mrps26 5000
Mrps5 4980
Mrpl57 4943
Mrps31 4919
Mrps9 4801
Mrps7 4702
Mrpl24 4636
Mrps17 4119
Mrps25 4107
Mrps30 4024
Mrps33 3898
Mrpl22 3803
Mrpl10 3780
Mrrf 3745
Mrpl9 3630
Mrpl1 3297
Ptcd3 2875
Mrpl16 2831
Mrpl23 2622
Mrps22 2148
Mrps18c 1111
Mtrf1l 723
Mrpl50 373
Mrps11 115
Mrpl32 -5017
Mrps6 -5238


ESTABLISHMENT OF SISTER CHROMATID COHESION
set ESTABLISHMENT OF SISTER CHROMATID COHESION
setSize 10
pANOVA 0.000334
s.dist -0.655
p.adjustANOVA 0.0033


Top enriched genes
Top 20 genes
GeneID Gene Rank
Esco2 -6571
Wapl -5743
Esco1 -5362
Pds5b -5315
Pds5a -4975
Stag1 -4854
Rad21 -4409
Stag2 -3987
Smc1a -3841
Smc3 -2920

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Esco2 -6571
Wapl -5743
Esco1 -5362
Pds5b -5315
Pds5a -4975
Stag1 -4854
Rad21 -4409
Stag2 -3987
Smc1a -3841
Smc3 -2920


AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT
set AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT
setSize 202
pANOVA 8.16e-58
s.dist 0.653
p.adjustANOVA 3.67e-55


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufab1 7795
Gpt 7783
Cox5a 7763
Suclg1 7756
mt-Nd6 7753
Sdha 7752
Isca2 7749
Dlat 7734
Cox7a1 7707
Sdhc 7674
Ndufv2 7671
Got1 7659
Ndufc2 7618
Dlst 7607
Ndufa5 7598
Pm20d1 7594
L2hgdh 7572
Ndufa6 7568
Etfdh 7551
Etfa 7536

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufab1 7795
Gpt 7783
Cox5a 7763
Suclg1 7756
mt-Nd6 7753
Sdha 7752
Isca2 7749
Dlat 7734
Cox7a1 7707
Sdhc 7674
Ndufv2 7671
Got1 7659
Ndufc2 7618
Dlst 7607
Ndufa5 7598
Pm20d1 7594
L2hgdh 7572
Ndufa6 7568
Etfdh 7551
Etfa 7536
Idh3b 7521
Idh3a 7496
Ndufs3 7485
Ndufa12 7479
Me3 7465
Uqcrc2 7441
Hspa9 7433
Mdh1 7413
Pdhx 7400
Acat1 7394
Ndufa3 7391
Etfb 7388
Ndufc1 7364
Fahd1 7361
Slc25a11 7339
Coa5 7335
Ndufa9 7325
Ndufs4 7323
Ndufs2 7313
Coq10a 7308
Uqcrh 7305
Ldhb 7303
Ndufb8 7300
Pdpr 7285
Timmdc1 7284
Ndufv3 7277
Lyrm7 7272
Ndufs1 7271
Ndufa4 7259
Nnt 7212
Sdhb 7210
Isca1 7203
Lyrm4 7182
Cox11 7179
Ndufa13 7147
Uqcrfs1 7145
Ndufb11 7141
Cs 7139
Adhfe1 7104
Ndufb9 7100
Sdhd 7099
Fh1 7090
Pdk2 7080
Cox5b 7063
Ndufs6 7038
Ndufs8 6993
Ndufaf3 6988
Cox6a2 6971
Cyc1 6957
Nfs1 6950
Uqcrq 6935
Cox4i1 6927
Sirt3 6919
Coa3 6848
Ndufb5 6842
Slc25a4 6841
Ndufb10 6806
Cox7a2 6780
Ndufb3 6767
Tmem177 6754
Ecsit 6750
Ndufs7 6749
Cox6c 6748
Pdp2 6738
Iscu 6727
Cox7c 6726
Pdhb 6706
Uqcrc1 6703
Ndufa10 6701
Vdac1 6640
Cycs 6637
Pcx 6633
Uqcrb 6620
Slc25a12 6617
Idh3g 6575
D2hgdh 6571
Cox6b1 6566
Hagh 6544
Ndufa7 6533
Sdhaf4 6482
Acad9 6468
Ndufa8 6448
Gstz1 6407
Smim20 6396
Cox19 6395
Cox7a2l 6385
Cox6b2 6234
Ndufa1 6200
Gid8 6057
Mdh2 5846
Pdk4 5809
Ndufaf4 5800
Ndufb6 5799
mt-Cytb 5778
Ndufb4 5756
Suclg2 5754
Got2 5656
Cox18 5641
Slc25a22 5634
Ndufv1 5612
Pgam5 5611
Cox20 5609
Ndufaf6 5517
Cox6a1 5470
Uqcr10 5424
Pdha1 5384
Ndufa11 5296
Higd1a 5218
Cox14 5188
Ndufs5 5100
Mrps36 5081
mt-Nd5 5023
Cox7b 5006
Lyrm2 4990
Sco1 4955
Ndufb7 4947
Ndufaf7 4809
Ogdh 4780
mt-Nd1 4753
Ndufa2 4733
Ndufaf2 4693
Ucp3 4604
Ndufaf1 4589
Sdhaf3 4556
Maea 4532
mt-Nd4 4527
Cox4i2 4474
Ndufaf5 4473
Tmem186 4437
Nubpl 4394
Ttc19 4223
mt-Nd2 4128
Ubc 4118
Timm21 4021
Dld 3955
Cox15 3896
Rmnd5b 3888
Glo1 3860
Fxn 3804
Sirt4 3782
Hccs 3299
Sdhaf1 3263
Hscb 3248
Trap1 3221
Tmem126b 3220
Me1 3143
Ndufb2 3010
mt-Co1 2990
Aco2 2934
Higd2a 2837
Pdk1 2799
Surf1 2712
Slc25a13 2617
Cox8a 2548
Sco2 2341
Me2 2132
Cmc1 2058
Ranbp9 1636
Ldha 1144
Pkm 976
Rps27a 888
Mkln1 601
Sdhaf2 538
Slc25a14 537
Idh2 410
Rmnd5a -284
Uba52 -311
Pdp1 -851
Sucla2 -1120
Cox16 -1138
Armc8 -2260
Slc25a27 -2488
Cox17 -2893
Pyurf -3016
Wdr26 -3159
Nek1 -3818
Gid4 -3928
Ubb -3950
Pdk3 -4035
Ucp2 -4573
Ldhal6b -4896
Coq10b -6920


HEME BIOSYNTHESIS
set HEME BIOSYNTHESIS
setSize 12
pANOVA 0.000161
s.dist 0.629
p.adjustANOVA 0.00184


Top enriched genes
Top 20 genes
GeneID Gene Rank
Uros 7105
Alad 6975
Alas1 6538
Fech 6513
Alb 6153
Hmbs 5571
Ppox 5071
Cox10 5005
Urod 4149
Cox15 3896
Cpox 3062
Alas2 -233

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Uros 7105
Alad 6975
Alas1 6538
Fech 6513
Alb 6153
Hmbs 5571
Ppox 5071
Cox10 5005
Urod 4149
Cox15 3896
Cpox 3062
Alas2 -233


MITOCHONDRIAL PROTEIN DEGRADATION
set MITOCHONDRIAL PROTEIN DEGRADATION
setSize 70
pANOVA 9.87e-20
s.dist 0.628
p.adjustANOVA 1.27e-17


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cox5a 7763
Acot1 7716
Ech1 7680
Ldhd 7663
Nadk2 7603
Idh3a 7496
Ndufs3 7485
Uqcrc2 7441
Hspa9 7433
Eci1 7431
Acat1 7394
Hmgcs2 7389
Hadh 7375
Hsd17b10 7282
Ndufv3 7277
Ndufs1 7271
Acot2 7256
Pmpca 7246
Ndufa13 7147
Cs 7139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cox5a 7763
Acot1 7716
Ech1 7680
Ldhd 7663
Nadk2 7603
Idh3a 7496
Ndufs3 7485
Uqcrc2 7441
Hspa9 7433
Eci1 7431
Acat1 7394
Hmgcs2 7389
Hadh 7375
Hsd17b10 7282
Ndufv3 7277
Ndufs1 7271
Acot2 7256
Pmpca 7246
Ndufa13 7147
Cs 7139
Fh1 7090
Mrpl12 7089
Mrps10 7078
Dbt 7077
Cox5b 7063
Uqcrq 6935
Oxct1 6878
Pdhb 6706
Alas1 6538
Fech 6513
Iars2 6405
Mrps2 6179
Bdh1 6064
Prkaca 6034
Lonp1 5870
Mdh2 5846
Suclg2 5754
Tfam 5741
Smdt1 5645
Ndufv1 5612
Aldh2 5602
Afg3l2 5595
Hspd1 5441
Pdha1 5384
Slc25a5 5327
Acadsb 5315
Clpx 5199
Ogdh 4780
Ndufa2 4733
Aldh1b1 4574
Shmt2 4300
Clpp 4142
Dld 3955
Spg7 3801
mt-Co1 2990
Aco2 2934
Pdk1 2799
Pccb 2577
Oxsm 2293
Me2 2132
Acad8 1682
Acot3 1109
Idh2 410
Star 186
Htra2 -717
Glud1 -1262
Aldh18a1 -2734
Ssbp1 -3049
App -4058
Mrpl32 -5017


COMPLEX IV ASSEMBLY
set COMPLEX IV ASSEMBLY
setSize 38
pANOVA 4.88e-11
s.dist 0.616
p.adjustANOVA 2.93e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cox5a 7763
Cox7a1 7707
Coa5 7335
Coq10a 7308
Ndufa4 7259
Cox11 7179
Cox5b 7063
Cox6a2 6971
Cox4i1 6927
Coa3 6848
Cox7a2 6780
Tmem177 6754
Cox6c 6748
Cox7c 6726
Cox6b1 6566
Smim20 6396
Cox19 6395
Cox7a2l 6385
Cox6b2 6234
Cox18 5641

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cox5a 7763
Cox7a1 7707
Coa5 7335
Coq10a 7308
Ndufa4 7259
Cox11 7179
Cox5b 7063
Cox6a2 6971
Cox4i1 6927
Coa3 6848
Cox7a2 6780
Tmem177 6754
Cox6c 6748
Cox7c 6726
Cox6b1 6566
Smim20 6396
Cox19 6395
Cox7a2l 6385
Cox6b2 6234
Cox18 5641
Cox20 5609
Cox6a1 5470
Higd1a 5218
Cox14 5188
Cox7b 5006
Sco1 4955
Cox4i2 4474
Timm21 4021
Cox15 3896
mt-Co1 2990
Higd2a 2837
Surf1 2712
Cox8a 2548
Sco2 2341
Cmc1 2058
Cox16 -1138
Cox17 -2893
Coq10b -6920


COHESIN LOADING ONTO CHROMATIN
set COHESIN LOADING ONTO CHROMATIN
setSize 10
pANOVA 0.000886
s.dist -0.607
p.adjustANOVA 0.00713


Top enriched genes
Top 20 genes
GeneID Gene Rank
Wapl -5743
Pds5b -5315
Pds5a -4975
Stag1 -4854
Nipbl -4813
Rad21 -4409
Stag2 -3987
Smc1a -3841
Mau2 -3457
Smc3 -2920

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Wapl -5743
Pds5b -5315
Pds5a -4975
Stag1 -4854
Nipbl -4813
Rad21 -4409
Stag2 -3987
Smc1a -3841
Mau2 -3457
Smc3 -2920


UBIQUINOL BIOSYNTHESIS
set UBIQUINOL BIOSYNTHESIS
setSize 11
pANOVA 0.000547
s.dist 0.602
p.adjustANOVA 0.00507


Top enriched genes
Top 20 genes
GeneID Gene Rank
Coq9 7535
Coq3 7383
Stard7 7356
Coq5 6850
Coq6 6315
Coq2 6111
Pdss1 3645
Coq7 3123
Pdss2 2391
Coq4 1422
Hpdl 422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Coq9 7535
Coq3 7383
Stard7 7356
Coq5 6850
Coq6 6315
Coq2 6111
Pdss1 3645
Coq7 3123
Pdss2 2391
Coq4 1422
Hpdl 422


AFLATOXIN ACTIVATION AND DETOXIFICATION
set AFLATOXIN ACTIVATION AND DETOXIFICATION
setSize 10
pANOVA 0.000984
s.dist 0.602
p.adjustANOVA 0.0077


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dpep1 7529
Mgst3 7173
Acy3 6765
Mgst1 6447
Ggt7 6365
Akr7a5 6317
Ggt1 5187
Acy1 5125
Ggt5 3992
Dpep2 -7134

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dpep1 7529
Mgst3 7173
Acy3 6765
Mgst1 6447
Ggt7 6365
Akr7a5 6317
Ggt1 5187
Acy1 5125
Ggt5 3992
Dpep2 -7134


REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
set REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize 14
pANOVA 0.000114
s.dist 0.596
p.adjustANOVA 0.00135


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dlat 7734
Pdhx 7400
Pdpr 7285
Pdk2 7080
Pdp2 6738
Pdhb 6706
Gstz1 6407
Pdk4 5809
Pdha1 5384
Dld 3955
Sirt4 3782
Pdk1 2799
Pdp1 -851
Pdk3 -4035

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dlat 7734
Pdhx 7400
Pdpr 7285
Pdk2 7080
Pdp2 6738
Pdhb 6706
Gstz1 6407
Pdk4 5809
Pdha1 5384
Dld 3955
Sirt4 3782
Pdk1 2799
Pdp1 -851
Pdk3 -4035


TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS
set TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS
setSize 11
pANOVA 0.000694
s.dist -0.591
p.adjustANOVA 0.00595


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tnfrsf1a -7012
Tnfrsf11b -6837
Tnfrsf1b -6682
Eda2r -6121
Tnfsf13b -5930
Tnfrsf25 -5574
Tnfrsf14 -4734
Eda -2825
Edar -2511
Tnfrsf13b -1558
Tnfsf13 2423

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tnfrsf1a -7012
Tnfrsf11b -6837
Tnfrsf1b -6682
Eda2r -6121
Tnfsf13b -5930
Tnfrsf25 -5574
Tnfrsf14 -4734
Eda -2825
Edar -2511
Tnfrsf13b -1558
Tnfsf13 2423


ASPIRIN ADME
set ASPIRIN ADME
setSize 17
pANOVA 3.89e-05
s.dist 0.576
p.adjustANOVA 0.000539


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ces1d 7705
Slco2b1 7507
Acsm5 7257
Alb 6153
Bsg 5927
Slc16a1 5264
Ugt1a7c 5263
Glyat 5142
Ugt3a2 4924
Cyp2e1 4543
Abcc3 4134
Acsm2 4080
Abcc2 3876
Ugt2b38 3417
Cyp2d22 2459
Bche 367
Ugt2b37 -148

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ces1d 7705
Slco2b1 7507
Acsm5 7257
Alb 6153
Bsg 5927
Slc16a1 5264
Ugt1a7c 5263
Glyat 5142
Ugt3a2 4924
Cyp2e1 4543
Abcc3 4134
Acsm2 4080
Abcc2 3876
Ugt2b38 3417
Cyp2d22 2459
Bche 367
Ugt2b37 -148


ER PHAGOSOME PATHWAY
set ER PHAGOSOME PATHWAY
setSize 19
pANOVA 2.38e-05
s.dist -0.56
p.adjustANOVA 0.000356


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2-Q6 -7424
H2-Q7 -7417
B2m -7409
H2-T22 -7408
H2-K1 -7407
H2-Q4 -7396
Tap1 -7282
H2-T23 -7168
H2-M3 -6202
H2-T10 -5883
Vamp3 -5880
Tap2 -4668
Pdia3 -3591
Tapbp -3404
Snap23 -2465
Sec22b 535
Calr 3306
Stx4a 3961
Vamp8 5864

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2-Q6 -7424
H2-Q7 -7417
B2m -7409
H2-T22 -7408
H2-K1 -7407
H2-Q4 -7396
Tap1 -7282
H2-T23 -7168
H2-M3 -6202
H2-T10 -5883
Vamp3 -5880
Tap2 -4668
Pdia3 -3591
Tapbp -3404
Snap23 -2465
Sec22b 535
Calr 3306
Stx4a 3961
Vamp8 5864


CHOLESTEROL BIOSYNTHESIS
set CHOLESTEROL BIOSYNTHESIS
setSize 26
pANOVA 1.74e-06
s.dist 0.542
p.adjustANOVA 3.9e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sqle 7711
Mvk 7708
Fdft1 7564
Dhcr7 7556
Plpp6 7406
Dhcr24 7387
Hmgcs1 6840
Msmo1 6687
Cyp51 6551
Srebf2 6472
Srebf1 6318
Mvd 6026
Idi1 5726
Pmvk 5598
Hsd17b7 5173
Tm7sf2 4421
Fdps 3572
Lss 2936
Nsdhl 2596
Lbr 2368

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sqle 7711
Mvk 7708
Fdft1 7564
Dhcr7 7556
Plpp6 7406
Dhcr24 7387
Hmgcs1 6840
Msmo1 6687
Cyp51 6551
Srebf2 6472
Srebf1 6318
Mvd 6026
Idi1 5726
Pmvk 5598
Hsd17b7 5173
Tm7sf2 4421
Fdps 3572
Lss 2936
Nsdhl 2596
Lbr 2368
Sc5d 2314
Acat2 2254
Ebp 70
Hmgcr -1353
Arv1 -3045
Ggps1 -4652


NON INTEGRIN MEMBRANE ECM INTERACTIONS
set NON INTEGRIN MEMBRANE ECM INTERACTIONS
setSize 30
pANOVA 4.18e-07
s.dist -0.534
p.adjustANOVA 1.14e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col11a1 -7259
Col4a3 -7227
Col5a2 -7209
Sdc3 -7141
Fn1 -7089
Col4a4 -7015
Col1a2 -6884
Col3a1 -6768
Ddr2 -6685
Itga6 -6569
Col4a2 -6504
Col4a1 -6011
Sdc2 -5683
Itga2 -5668
Col1a1 -5269
Fgf2 -5254
Col5a1 -4764
Col4a5 -4615
Itgb1 -4513
Col11a2 -3186

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col11a1 -7259
Col4a3 -7227
Col5a2 -7209
Sdc3 -7141
Fn1 -7089
Col4a4 -7015
Col1a2 -6884
Col3a1 -6768
Ddr2 -6685
Itga6 -6569
Col4a2 -6504
Col4a1 -6011
Sdc2 -5683
Itga2 -5668
Col1a1 -5269
Fgf2 -5254
Col5a1 -4764
Col4a5 -4615
Itgb1 -4513
Col11a2 -3186
Sdc4 -3077
Sdc1 -2888
Itgav -2619
Ddr1 -2458
Itgb4 -1988
Tgfb1 -1753
Itgb3 -1052
Col5a3 6912
Col4a6 7012
Vtn 7193


DEGRADATION OF CYSTEINE AND HOMOCYSTEINE
set DEGRADATION OF CYSTEINE AND HOMOCYSTEINE
setSize 10
pANOVA 0.0041
s.dist 0.524
p.adjustANOVA 0.0226


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdo1 7358
Suox 7309
Txn2 7242
Ethe1 6895
Slc25a10 5513
Tst 4722
Ado 4634
Mpst 3172
Cth 1833
Fmo1 -6813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdo1 7358
Suox 7309
Txn2 7242
Ethe1 6895
Slc25a10 5513
Tst 4722
Ado 4634
Mpst 3172
Cth 1833
Fmo1 -6813


BIOTIN TRANSPORT AND METABOLISM
set BIOTIN TRANSPORT AND METABOLISM
setSize 11
pANOVA 0.00305
s.dist 0.516
p.adjustANOVA 0.0179


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mccc2 7683
Mccc1 7167
Acacb 7011
Pcx 6633
Pcca 6554
Hlcs 5448
Pccb 2577
Slc5a6 1952
Acaca 1795
Btd -520
Pdzd11 -948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mccc2 7683
Mccc1 7167
Acacb 7011
Pcx 6633
Pcca 6554
Hlcs 5448
Pccb 2577
Slc5a6 1952
Acaca 1795
Btd -520
Pdzd11 -948


INFLAMMASOMES
set INFLAMMASOMES
setSize 12
pANOVA 0.00209
s.dist -0.513
p.adjustANOVA 0.0136


Top enriched genes
Top 20 genes
GeneID Gene Rank
Bcl2 -7207
P2rx7 -6882
Pstpip1 -6773
Aim2 -6128
Bcl2l1 -5371
Txn1 -4381
Pycard -3735
Sugt1 -3038
Panx1 -2953
Txnip -1847
Hsp90ab1 839
Nlrp3 2909

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bcl2 -7207
P2rx7 -6882
Pstpip1 -6773
Aim2 -6128
Bcl2l1 -5371
Txn1 -4381
Pycard -3735
Sugt1 -3038
Panx1 -2953
Txnip -1847
Hsp90ab1 839
Nlrp3 2909


ACYL CHAIN REMODELLING OF PE
set ACYL CHAIN REMODELLING OF PE
setSize 15
pANOVA 0.000617
s.dist 0.511
p.adjustANOVA 0.00549


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pla2g5 7775
Lpcat3 7769
Pla2g4e 7612
Pla2g12a 7411
Abhd4 6755
Pla2g6 6458
Plbd1 6400
Mboat1 6399
Pla2g4b 4916
Mboat2 4740
Pnpla8 3993
Pla2r1 3017
Pla2g2d -1374
Lpcat4 -3498
Pla2g4a -7155

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pla2g5 7775
Lpcat3 7769
Pla2g4e 7612
Pla2g12a 7411
Abhd4 6755
Pla2g6 6458
Plbd1 6400
Mboat1 6399
Pla2g4b 4916
Mboat2 4740
Pnpla8 3993
Pla2r1 3017
Pla2g2d -1374
Lpcat4 -3498
Pla2g4a -7155


LYSINE CATABOLISM
set LYSINE CATABOLISM
setSize 10
pANOVA 0.0055
s.dist 0.507
p.adjustANOVA 0.0275


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dlst 7607
Aldh7a1 6080
Gcdh 6021
Dhtkd1 4449
Aass 4286
Dld 3955
Hykk 3788
Pipox 2382
Crym 1033
Phykpl 953

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dlst 7607
Aldh7a1 6080
Gcdh 6021
Dhtkd1 4449
Aass 4286
Dld 3955
Hykk 3788
Pipox 2382
Crym 1033
Phykpl 953


SULFUR AMINO ACID METABOLISM
set SULFUR AMINO ACID METABOLISM
setSize 19
pANOVA 0.000142
s.dist 0.504
p.adjustANOVA 0.00166


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdo1 7358
Suox 7309
Txn2 7242
Ethe1 6895
Mri1 6820
Adi1 6249
Slc25a10 5513
Mat1a 5186
Mtap 4915
Tst 4722
Ado 4634
Mtr 4042
Cbs 3198
Mpst 3172
Enoph1 2415
Mtrr 2025
Cth 1833
Ahcy -128
Fmo1 -6813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdo1 7358
Suox 7309
Txn2 7242
Ethe1 6895
Mri1 6820
Adi1 6249
Slc25a10 5513
Mat1a 5186
Mtap 4915
Tst 4722
Ado 4634
Mtr 4042
Cbs 3198
Mpst 3172
Enoph1 2415
Mtrr 2025
Cth 1833
Ahcy -128
Fmo1 -6813


PEROXISOMAL LIPID METABOLISM
set PEROXISOMAL LIPID METABOLISM
setSize 27
pANOVA 6.66e-06
s.dist 0.501
p.adjustANOVA 0.000128


Top enriched genes
Top 20 genes
GeneID Gene Rank
Crat 7440
Hsd17b4 7386
Amacr 7354
Mlycd 7253
Pecr 7055
Acot4 6979
Phyh 6834
Abcd1 6524
Scp2 6298
Acox1 6296
Decr2 6052
Acbd4 5707
Eci2 5688
Acot6 5103
Acaa1b 5040
Hao2 4888
Nudt19 3921
Slc27a2 3822
Acox2 3469
Hacl1 2670

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crat 7440
Hsd17b4 7386
Amacr 7354
Mlycd 7253
Pecr 7055
Acot4 6979
Phyh 6834
Abcd1 6524
Scp2 6298
Acox1 6296
Decr2 6052
Acbd4 5707
Eci2 5688
Acot6 5103
Acaa1b 5040
Hao2 4888
Nudt19 3921
Slc27a2 3822
Acox2 3469
Hacl1 2670
Acot8 2283
Ehhadh 2218
Aldh3a2 261
Acox3 -1454
Acbd5 -2692
Slc25a17 -3171
Crot -5131


MET ACTIVATES PTK2 SIGNALING
set MET ACTIVATES PTK2 SIGNALING
setSize 18
pANOVA 0.000414
s.dist -0.481
p.adjustANOVA 0.00396


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col11a1 -7259
Col5a2 -7209
Fn1 -7089
Col1a2 -6884
Col3a1 -6768
Ptk2 -6120
Itga2 -5668
Col1a1 -5269
Lama4 -4820
Col5a1 -4764
Itgb1 -4513
Megf6 -4053
Col11a2 -3186
Hgf -2820
Itga3 -911
Src 2088
Met 5923
Col5a3 6912

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col11a1 -7259
Col5a2 -7209
Fn1 -7089
Col1a2 -6884
Col3a1 -6768
Ptk2 -6120
Itga2 -5668
Col1a1 -5269
Lama4 -4820
Col5a1 -4764
Itgb1 -4513
Megf6 -4053
Col11a2 -3186
Hgf -2820
Itga3 -911
Src 2088
Met 5923
Col5a3 6912


CHONDROITIN SULFATE BIOSYNTHESIS
set CHONDROITIN SULFATE BIOSYNTHESIS
setSize 16
pANOVA 0.000957
s.dist -0.477
p.adjustANOVA 0.00755


Top enriched genes
Top 20 genes
GeneID Gene Rank
Bgn -7217
Dcn -7031
Chst11 -6906
Chsy1 -6900
Chst15 -6643
Chsy3 -6039
Csgalnact1 -5637
Chpf2 -5048
Csgalnact2 -4539
Chpf -2667
Cspg5 -2233
Vcan -2022
Chst7 -1697
Chst12 1815
Cspg4 3281
Chst3 4465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bgn -7217
Dcn -7031
Chst11 -6906
Chsy1 -6900
Chst15 -6643
Chsy3 -6039
Csgalnact1 -5637
Chpf2 -5048
Csgalnact2 -4539
Chpf -2667
Cspg5 -2233
Vcan -2022
Chst7 -1697
Chst12 1815
Cspg4 3281
Chst3 4465


SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
set SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
setSize 14
pANOVA 0.00202
s.dist 0.477
p.adjustANOVA 0.0133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hsd17b4 7386
Amacr 7354
Scp2 6298
Rxra 6270
Hsd3b7 4758
Akr1c21 4519
Slc27a2 3822
Ncoa1 3491
Acox2 3469
Cyp27a1 3260
Acot8 2283
Nr1h4 1472
Ncoa2 384
Cyp7b1 -1247

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsd17b4 7386
Amacr 7354
Scp2 6298
Rxra 6270
Hsd3b7 4758
Akr1c21 4519
Slc27a2 3822
Ncoa1 3491
Acox2 3469
Cyp27a1 3260
Acot8 2283
Nr1h4 1472
Ncoa2 384
Cyp7b1 -1247


SYNDECAN INTERACTIONS
set SYNDECAN INTERACTIONS
setSize 14
pANOVA 0.00202
s.dist -0.476
p.adjustANOVA 0.0133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sdc3 -7141
Fn1 -7089
Itga6 -6569
Sdc2 -5683
Itga2 -5668
Fgf2 -5254
Itgb1 -4513
Sdc4 -3077
Sdc1 -2888
Itgav -2619
Itgb4 -1988
Tgfb1 -1753
Itgb3 -1052
Vtn 7193

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sdc3 -7141
Fn1 -7089
Itga6 -6569
Sdc2 -5683
Itga2 -5668
Fgf2 -5254
Itgb1 -4513
Sdc4 -3077
Sdc1 -2888
Itgav -2619
Itgb4 -1988
Tgfb1 -1753
Itgb3 -1052
Vtn 7193


TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES
set TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES
setSize 30
pANOVA 7.3e-06
s.dist -0.473
p.adjustANOVA 0.000134


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cenpj -6934
Cdk1 -6929
E2f7 -6729
Cnot6 -6724
Aurka -6662
Cdkn1b -6625
Ccne1 -6321
Cnot2 -6274
Ccna2 -6085
Gadd45a -4997
Btg2 -4363
Cnot6l -4257
Tnks1bp1 -4232
Ccne2 -3847
Plk2 -3814
Pcna -3650
Cnot4 -3503
Cnot1 -3239
Cnot3 -3027
Cdk2 -2853

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cenpj -6934
Cdk1 -6929
E2f7 -6729
Cnot6 -6724
Aurka -6662
Cdkn1b -6625
Ccne1 -6321
Cnot2 -6274
Ccna2 -6085
Gadd45a -4997
Btg2 -4363
Cnot6l -4257
Tnks1bp1 -4232
Ccne2 -3847
Plk2 -3814
Pcna -3650
Cnot4 -3503
Cnot1 -3239
Cnot3 -3027
Cdk2 -2853
Cdkn1a -2738
Npm1 -2028
Sfn -1883
Cnot10 -1693
Cnot7 -923
E2f8 758
Cnot8 921
Plk3 1373
Bax 1394
Cnot11 3703


ACTIVATION OF THE PRE REPLICATIVE COMPLEX
set ACTIVATION OF THE PRE REPLICATIVE COMPLEX
setSize 31
pANOVA 5.32e-06
s.dist -0.472
p.adjustANOVA 0.000104


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mcm2 -7401
Mcm3 -7281
Mcm4 -7258
Mcm5 -7121
Mcm7 -6935
Cdc6 -6710
Mcm6 -6091
Cdt1 -5975
Mcm10 -5936
Dbf4 -5801
Pole -5746
Prim1 -5670
Rpa2 -5601
Cdc7 -5348
Orc2 -5218
Pola1 -4293
Prim2 -4133
Mcm8 -3840
Cdk2 -2853
Pola2 -2438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mcm2 -7401
Mcm3 -7281
Mcm4 -7258
Mcm5 -7121
Mcm7 -6935
Cdc6 -6710
Mcm6 -6091
Cdt1 -5975
Mcm10 -5936
Dbf4 -5801
Pole -5746
Prim1 -5670
Rpa2 -5601
Cdc7 -5348
Orc2 -5218
Pola1 -4293
Prim2 -4133
Mcm8 -3840
Cdk2 -2853
Pola2 -2438
Cdc45 -2262
Orc4 -1399
Orc3 -1167
Orc6 -1133
Rpa1 -432
Pole3 183
Orc5 310
Pole2 1167
Pole4 1276
Rpa3 3982
Gmnn 5720


COLLAGEN CHAIN TRIMERIZATION
set COLLAGEN CHAIN TRIMERIZATION
setSize 34
pANOVA 1.93e-06
s.dist -0.472
p.adjustANOVA 4.24e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col14a1 -7413
Col8a1 -7349
Col12a1 -7275
Col11a1 -7259
Col4a3 -7227
Col5a2 -7209
Col6a1 -7170
Col8a2 -7100
Col4a4 -7015
Col13a1 -6927
Col22a1 -6901
Col1a2 -6884
Col3a1 -6768
Col16a1 -6756
Col6a2 -6620
Col4a2 -6504
Col4a1 -6011
Col26a1 -5287
Col1a1 -5269
Col5a1 -4764

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col14a1 -7413
Col8a1 -7349
Col12a1 -7275
Col11a1 -7259
Col4a3 -7227
Col5a2 -7209
Col6a1 -7170
Col8a2 -7100
Col4a4 -7015
Col13a1 -6927
Col22a1 -6901
Col1a2 -6884
Col3a1 -6768
Col16a1 -6756
Col6a2 -6620
Col4a2 -6504
Col4a1 -6011
Col26a1 -5287
Col1a1 -5269
Col5a1 -4764
Col4a5 -4615
Col15a1 -3977
Col25a1 -3781
Col28a1 -3687
Col11a2 -3186
Col6a3 -3148
Col23a1 -3080
Col9a2 4161
Col18a1 4992
Col7a1 5428
Col5a3 6912
Col4a6 7012
Col20a1 7524
Col6a6 7731


ABC TRANSPORTERS IN LIPID HOMEOSTASIS
set ABC TRANSPORTERS IN LIPID HOMEOSTASIS
setSize 14
pANOVA 0.00243
s.dist 0.468
p.adjustANOVA 0.0151


Top enriched genes
Top 20 genes
GeneID Gene Rank
Abca7 7374
Abca2 6980
Abcd1 6524
Pex19 6470
Abcd2 6403
Apoa1 6354
Abca3 6098
Abcd3 6092
Abca5 5166
Abca12 4986
Abca6 1781
Abca9 -1925
Pex3 -3216
Abcg1 -6477

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Abca7 7374
Abca2 6980
Abcd1 6524
Pex19 6470
Abcd2 6403
Apoa1 6354
Abca3 6098
Abcd3 6092
Abca5 5166
Abca12 4986
Abca6 1781
Abca9 -1925
Pex3 -3216
Abcg1 -6477


NCAM1 INTERACTIONS
set NCAM1 INTERACTIONS
setSize 16
pANOVA 0.00128
s.dist -0.465
p.adjustANOVA 0.00962


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col4a3 -7227
Col5a2 -7209
Col6a1 -7170
Col4a4 -7015
Col3a1 -6768
Col6a2 -6620
Col4a2 -6504
Col4a1 -6011
Col5a1 -4764
Col4a5 -4615
Col6a3 -3148
St8sia4 -2913
St8sia2 -2395
Col9a2 4161
Col5a3 6912
Col6a6 7731

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col4a3 -7227
Col5a2 -7209
Col6a1 -7170
Col4a4 -7015
Col3a1 -6768
Col6a2 -6620
Col4a2 -6504
Col4a1 -6011
Col5a1 -4764
Col4a5 -4615
Col6a3 -3148
St8sia4 -2913
St8sia2 -2395
Col9a2 4161
Col5a3 6912
Col6a6 7731


COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
set COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
setSize 53
pANOVA 6.11e-09
s.dist -0.462
p.adjustANOVA 2.29e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col14a1 -7413
Col8a1 -7349
Adamts3 -7310
Col12a1 -7275
Col11a1 -7259
Adamts2 -7232
Col4a3 -7227
Col5a2 -7209
Col6a1 -7170
Plod2 -7120
Col8a2 -7100
Col4a4 -7015
Col13a1 -6927
Col22a1 -6901
Col1a2 -6884
Col3a1 -6768
Col16a1 -6756
Col6a2 -6620
Col4a2 -6504
Pcolce2 -6375

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col14a1 -7413
Col8a1 -7349
Adamts3 -7310
Col12a1 -7275
Col11a1 -7259
Adamts2 -7232
Col4a3 -7227
Col5a2 -7209
Col6a1 -7170
Plod2 -7120
Col8a2 -7100
Col4a4 -7015
Col13a1 -6927
Col22a1 -6901
Col1a2 -6884
Col3a1 -6768
Col16a1 -6756
Col6a2 -6620
Col4a2 -6504
Pcolce2 -6375
Tll2 -6099
Col4a1 -6011
Col26a1 -5287
Col1a1 -5269
P3h3 -5069
Col5a1 -4764
P4hb -4687
Pcolce -4622
Col4a5 -4615
Colgalt2 -4249
Tll1 -4233
Col15a1 -3977
P4ha1 -3830
Col25a1 -3781
Col28a1 -3687
Plod1 -3359
Col11a2 -3186
Col6a3 -3148
Col23a1 -3080
Bmp1 -2394
Colgalt1 -2325
P4ha2 -2123
Serpinh1 -1160
Adamts14 2129
Plod3 2737
Col9a2 4161
Col18a1 4992
Col7a1 5428
Col5a3 6912
Col4a6 7012
P3h2 7124
Col20a1 7524
Col6a6 7731


MITOCHONDRIAL BIOGENESIS
set MITOCHONDRIAL BIOGENESIS
setSize 10
pANOVA 0.0125
s.dist 0.456
p.adjustANOVA 0.0538


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acss2 7739
Sod2 7639
Sirt5 6985
Sirt3 6919
Cycs 6637
Sirt4 3782
Idh2 410
Gabpa 31
Glud1 -1262
Gabpb1 -2221

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acss2 7739
Sod2 7639
Sirt5 6985
Sirt3 6919
Cycs 6637
Sirt4 3782
Idh2 410
Gabpa 31
Glud1 -1262
Gabpb1 -2221


TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS
set TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS
setSize 10
pANOVA 0.0125
s.dist 0.456
p.adjustANOVA 0.0538


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acss2 7739
Sod2 7639
Sirt5 6985
Sirt3 6919
Cycs 6637
Sirt4 3782
Idh2 410
Gabpa 31
Glud1 -1262
Gabpb1 -2221

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acss2 7739
Sod2 7639
Sirt5 6985
Sirt3 6919
Cycs 6637
Sirt4 3782
Idh2 410
Gabpa 31
Glud1 -1262
Gabpb1 -2221


PEROXISOMAL PROTEIN IMPORT
set PEROXISOMAL PROTEIN IMPORT
setSize 61
pANOVA 8.93e-10
s.dist 0.454
p.adjustANOVA 4.14e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gstk1 7779
Acot1 7716
Ephx2 7699
Ech1 7680
Nudt7 7515
Cat 7462
Crat 7440
Hsd17b4 7386
Amacr 7354
Acot2 7256
Mlycd 7253
Pecr 7055
Ddo 6984
Acot4 6979
Phyh 6834
Ube2d2a 6732
Gnpat 6437
Scp2 6298
Acox1 6296
Mpv17 6195

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gstk1 7779
Acot1 7716
Ephx2 7699
Ech1 7680
Nudt7 7515
Cat 7462
Crat 7440
Hsd17b4 7386
Amacr 7354
Acot2 7256
Mlycd 7253
Pecr 7055
Ddo 6984
Acot4 6979
Phyh 6834
Ube2d2a 6732
Gnpat 6437
Scp2 6298
Acox1 6296
Mpv17 6195
Hmgcl 6149
Decr2 6052
Dao 5894
Eci2 5688
Dhrs4 5410
Pex5 5365
Acaa1b 5040
Hao2 4888
Pex6 4436
Ide 4136
Ubc 4118
Pex10 3998
Idh1 3991
Nudt19 3921
Slc27a2 3822
Acox2 3469
Lonp2 3406
Pex7 3305
Hacl1 2670
Pex1 2549
Tysnd1 2428
Pipox 2382
Acot8 2283
Ehhadh 2218
Pex13 1966
Pex2 1779
Ube2d1 1502
Pex14 1465
Acot3 1109
Rps27a 888
Pex26 846
Uba52 -311
Ube2d3 -470
Acox3 -1454
Usp9x -1610
Pex12 -2156
Nos2 -3263
Zfand6 -3774
Ubb -3950
Crot -5131
Paox -5556


CONDENSATION OF PROPHASE CHROMOSOMES
set CONDENSATION OF PROPHASE CHROMOSOMES
setSize 12
pANOVA 0.00717
s.dist -0.448
p.adjustANOVA 0.0341


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdk1 -6929
Plk1 -6765
Smc2 -6279
H3f3a -5878
Smc4 -5534
Ncapg2 -4538
Set -3320
Rb1 -1231
Ncaph2 -272
Ncapd3 173
H3f3b 517
Mcph1 1395

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdk1 -6929
Plk1 -6765
Smc2 -6279
H3f3a -5878
Smc4 -5534
Ncapg2 -4538
Set -3320
Rb1 -1231
Ncaph2 -272
Ncapd3 173
H3f3b 517
Mcph1 1395


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] kableExtra_1.4.0 pkgload_1.4.0    GGally_2.2.1     ggplot2_3.5.1   
##  [5] reshape2_1.4.4   beeswarm_0.4.0   gplots_3.2.0     gtools_3.9.5    
##  [9] tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5  mitch_1.17.4    
## 
## loaded via a namespace (and not attached):
##  [1] sass_0.4.9         utf8_1.2.4         generics_0.1.3     tidyr_1.3.1       
##  [5] bitops_1.0-9       xml2_1.3.6         KernSmooth_2.23-24 stringi_1.8.4     
##  [9] caTools_1.18.3     digest_0.6.37      magrittr_2.0.3     evaluate_1.0.1    
## [13] grid_4.4.1         RColorBrewer_1.1-3 fastmap_1.2.0      plyr_1.8.9        
## [17] jsonlite_1.8.9     gridExtra_2.3      promises_1.3.0     purrr_1.0.2       
## [21] fansi_1.0.6        viridisLite_0.4.2  scales_1.3.0       jquerylib_0.1.4   
## [25] cli_3.6.3          shiny_1.9.1        rlang_1.1.4        munsell_0.5.1     
## [29] withr_3.0.1        cachem_1.1.0       yaml_2.3.10        parallel_4.4.1    
## [33] tools_4.4.1        colorspace_2.1-1   httpuv_1.6.15      ggstats_0.7.0     
## [37] vctrs_0.6.5        R6_2.5.1           mime_0.12          lifecycle_1.0.4   
## [41] stringr_1.5.1      htmlwidgets_1.6.4  MASS_7.3-61        pkgconfig_2.0.3   
## [45] pillar_1.9.0       bslib_0.8.0        later_1.3.2        gtable_0.3.5      
## [49] glue_1.8.0         Rcpp_1.0.13        systemfonts_1.1.0  highr_0.11        
## [53] xfun_0.48          tidyselect_1.2.1   rstudioapi_0.17.1  knitr_1.48        
## [57] xtable_1.8-4       htmltools_0.5.8.1  rmarkdown_2.28     svglite_2.1.3     
## [61] compiler_4.4.1

END of report