Mitch Report

date generated: 2024-10-24

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
0610007P14Rik	-0.0392645	-0.3486404	-0.1746777
0610009B22Rik	-0.0028689	-13.7043137	2.6807732
0610009E02Rik	-0.2454686	-0.0834285	-0.4418131
0610009L18Rik	0.9803795	-3.3723116	0.5270304
0610009O20Rik	-0.3821166	-135.7937142	2.4027199
0610010F05Rik	0.5840653	0.2881691	-0.2676758

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	15245
duplicated_genes_present	0
num_profile_genes_in_sets	6763
num_profile_genes_not_in_sets	8482

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	1289
num_genesets_excluded	389
num_genesets_included	900

Genes by sector

wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk	Count
-1	-1	-1	1378
1	-1	-1	1402
-1	1	-1	2363
1	1	-1	2286
-1	1	0	1
-1	-1	1	2500
1	-1	1	2519
-1	1	1	1306
1	1	1	1490

Number of significant gene sets (FDR<0.05)= 373

Gene sets by sector

Gene sets by sector

s.wt_gal3ko	s.wt_mst1ox	s.mst1ox_mst1oxk	Count
-1	-1	-1	80
1	-1	-1	18
-1	1	-1	130
1	1	-1	25
-1	-1	1	74
1	-1	1	30
-1	1	1	14
1	1	1	2

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.wt_gal3ko	s.wt_mst1ox	s.mst1ox_mst1oxk	p.wt_gal3ko	p.wt_mst1ox	p.mst1ox_mst1oxk
ENDOSOMAL VACUOLAR PATHWAY	10	7.64e-08	1.21e-06	1.230	-0.6850	0.5500	-0.8630	1.74e-04	2.60e-03	2.26e-06
COMPLEX I BIOGENESIS	58	5.31e-39	9.55e-37	1.200	0.1890	-0.9070	0.7660	1.30e-02	5.55e-33	5.14e-24
PROTEIN LIPOYLATION	10	1.19e-06	1.43e-05	1.190	0.0319	-0.8550	0.8210	8.62e-01	2.80e-06	6.85e-06
COMPLEX III ASSEMBLY	17	4.92e-11	1.13e-09	1.180	0.2640	-0.8290	0.8020	5.92e-02	3.21e-09	1.00e-08
BRANCHED CHAIN AMINO ACID CATABOLISM	20	5.57e-13	1.62e-11	1.180	0.1640	-0.8840	0.7680	2.04e-01	7.67e-12	2.75e-09
CITRIC ACID CYCLE TCA CYCLE	33	1.62e-20	1.32e-18	1.150	0.1550	-0.8860	0.7230	1.23e-01	1.14e-18	6.56e-13
RESPIRATORY ELECTRON TRANSPORT	124	1.52e-74	4.56e-72	1.140	0.2060	-0.8430	0.7340	7.71e-05	1.76e-59	2.20e-45
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	8.22e-19	5.28e-17	1.110	0.0558	-0.8240	0.7390	5.79e-01	2.49e-16	2.01e-13
UBIQUINOL BIOSYNTHESIS	11	6.39e-07	8.21e-06	1.100	-0.2920	-0.8750	0.6020	9.42e-02	5.03e-07	5.47e-04
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE	18	3.45e-10	7.05e-09	1.100	0.0965	-0.8290	0.7180	4.78e-01	1.12e-09	1.34e-07
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	10	2.10e-05	1.80e-04	1.070	0.1660	-0.7300	0.7610	3.65e-01	6.33e-05	3.06e-05
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT	202	0.00e+00	1.60e-98	1.040	0.1760	-0.7860	0.6530	1.65e-05	3.09e-83	8.16e-58
MITOCHONDRIAL TRANSLATION	87	7.76e-43	1.75e-40	1.030	0.0383	-0.7770	0.6700	5.37e-01	3.76e-36	2.88e-27
CROSSLINKING OF COLLAGEN FIBRILS	18	6.68e-09	1.16e-07	1.030	-0.3400	0.6920	-0.6760	1.25e-02	3.64e-07	6.88e-07
MITOCHONDRIAL PROTEIN DEGRADATION	70	5.27e-32	5.27e-30	0.989	0.0661	-0.7610	0.6280	3.39e-01	2.72e-28	9.87e-20
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	5.66e-05	3.92e-04	0.970	0.0169	-0.6700	0.7010	9.22e-01	1.18e-04	5.73e-05
COMPLEX IV ASSEMBLY	38	1.80e-16	7.72e-15	0.966	0.2260	-0.7090	0.6160	1.59e-02	3.85e-14	4.88e-11
COLLAGEN CHAIN TRIMERIZATION	34	9.66e-15	3.34e-13	0.936	-0.3400	0.7330	-0.4720	6.05e-04	1.31e-13	1.93e-06
HEME BIOSYNTHESIS	12	4.81e-05	3.55e-04	0.929	-0.0591	-0.6820	0.6290	7.23e-01	4.34e-05	1.61e-04
NCAM1 INTERACTIONS	16	6.12e-07	7.98e-06	0.922	-0.5010	0.6190	-0.4650	5.23e-04	1.80e-05	1.28e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	14	1.20e-05	1.11e-04	0.921	0.1810	-0.6790	0.5960	2.40e-01	1.08e-05	1.14e-04
NON INTEGRIN MEMBRANE ECM INTERACTIONS	30	4.35e-11	1.03e-09	0.881	-0.3430	0.6120	-0.5340	1.16e-03	6.50e-09	4.18e-07
MITOCHONDRIAL BIOGENESIS	10	5.26e-04	2.50e-03	0.879	0.1410	-0.7380	0.4560	4.39e-01	5.36e-05	1.25e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	10	5.26e-04	2.50e-03	0.879	0.1410	-0.7380	0.4560	4.39e-01	5.36e-05	1.25e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	14	3.41e-05	2.65e-04	0.874	0.0030	-0.5550	0.6750	9.84e-01	3.27e-04	1.21e-05
MET ACTIVATES PTK2 SIGNALING	18	2.00e-06	2.28e-05	0.855	-0.1920	0.6810	-0.4810	1.59e-01	5.66e-07	4.14e-04
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	53	1.82e-18	1.09e-16	0.850	-0.2720	0.6590	-0.4620	6.11e-04	9.90e-17	6.11e-09
ER PHAGOSOME PATHWAY	19	4.73e-07	6.55e-06	0.835	-0.5180	0.3410	-0.5600	9.27e-05	1.01e-02	2.38e-05
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	42	3.37e-14	1.12e-12	0.831	-0.3660	0.6020	-0.4400	4.11e-05	1.45e-11	8.07e-07
ECM PROTEOGLYCANS	35	8.08e-12	2.03e-10	0.827	-0.3030	0.6420	-0.4250	1.96e-03	4.73e-11	1.36e-05
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	11	1.31e-03	5.19e-03	0.816	-0.1900	0.5290	-0.5910	2.76e-01	2.36e-03	6.94e-04
LAMININ INTERACTIONS	15	3.98e-05	3.04e-04	0.814	-0.2940	0.6470	-0.3960	4.88e-02	1.42e-05	7.89e-03
CHONDROITIN SULFATE BIOSYNTHESIS	16	5.08e-05	3.63e-04	0.802	-0.2050	0.6120	-0.4770	1.55e-01	2.27e-05	9.57e-04
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	10	3.85e-03	1.27e-02	0.790	0.0738	-0.5860	0.5240	6.86e-01	1.33e-03	4.10e-03
COLLAGEN FORMATION	65	2.33e-19	1.75e-17	0.788	-0.2900	0.5860	-0.4390	5.16e-05	3.06e-16	9.21e-10
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	11	2.12e-03	7.84e-03	0.756	-0.4440	0.4690	-0.3920	1.08e-02	7.03e-03	2.45e-02
METABOLISM OF COFACTORS	23	1.23e-06	1.46e-05	0.752	-0.1090	-0.6230	0.4080	3.64e-01	2.35e-07	7.14e-04
ELASTIC FIBRE FORMATION	36	1.41e-09	2.58e-08	0.733	-0.1480	0.6100	-0.3790	1.24e-01	2.34e-10	8.43e-05
PEROXISOMAL PROTEIN IMPORT	61	4.08e-15	1.47e-13	0.725	0.0126	-0.5660	0.4540	8.65e-01	2.03e-14	8.93e-10
CS DS DEGRADATION	11	4.53e-04	2.23e-03	0.717	-0.2430	0.6700	-0.0758	1.64e-01	1.18e-04	6.63e-01
AFLATOXIN ACTIVATION AND DETOXIFICATION	10	7.47e-03	2.13e-02	0.710	-0.0964	-0.3650	0.6020	5.98e-01	4.56e-02	9.84e-04
SYNDECAN INTERACTIONS	14	1.45e-03	5.64e-03	0.707	-0.3110	0.4190	-0.4760	4.42e-02	6.59e-03	2.02e-03
BIOTIN TRANSPORT AND METABOLISM	11	4.98e-03	1.54e-02	0.704	-0.2230	-0.4230	0.5160	2.01e-01	1.50e-02	3.05e-03
SULFUR AMINO ACID METABOLISM	19	1.33e-04	8.06e-04	0.703	-0.0513	-0.4880	0.5040	6.99e-01	2.34e-04	1.42e-04
PYRUVATE METABOLISM	42	7.20e-10	1.38e-08	0.697	0.1060	-0.5690	0.3880	2.33e-01	1.71e-10	1.38e-05
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	29	4.95e-07	6.75e-06	0.693	-0.1430	0.5840	-0.3450	1.84e-01	5.33e-08	1.32e-03
PEROXISOMAL LIPID METABOLISM	27	3.82e-06	4.04e-05	0.689	-0.0372	-0.4720	0.5010	7.38e-01	2.23e-05	6.66e-06
MITOTIC TELOPHASE CYTOKINESIS	13	1.07e-04	6.76e-04	0.687	0.1250	0.0466	-0.6740	4.36e-01	7.71e-01	2.55e-05
INTEGRIN CELL SURFACE INTERACTIONS	65	3.82e-14	1.23e-12	0.679	-0.2500	0.4760	-0.4150	4.87e-04	3.14e-11	7.40e-09
GENERATION OF SECOND MESSENGER MOLECULES	12	2.17e-04	1.19e-03	0.677	-0.5180	-0.1800	-0.3960	1.89e-03	2.81e-01	1.74e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.wt_gal3ko	s.wt_mst1ox	s.mst1ox_mst1oxk	p.wt_gal3ko	p.wt_mst1ox	p.mst1ox_mst1oxk
ENDOSOMAL VACUOLAR PATHWAY	10	7.64e-08	1.21e-06	1.2300	-0.685000	5.50e-01	-0.863000	1.74e-04	2.60e-03	2.26e-06
COMPLEX I BIOGENESIS	58	5.31e-39	9.55e-37	1.2000	0.189000	-9.07e-01	0.766000	1.30e-02	5.55e-33	5.14e-24
PROTEIN LIPOYLATION	10	1.19e-06	1.43e-05	1.1900	0.031900	-8.55e-01	0.821000	8.62e-01	2.80e-06	6.85e-06
COMPLEX III ASSEMBLY	17	4.92e-11	1.13e-09	1.1800	0.264000	-8.29e-01	0.802000	5.92e-02	3.21e-09	1.00e-08
BRANCHED CHAIN AMINO ACID CATABOLISM	20	5.57e-13	1.62e-11	1.1800	0.164000	-8.84e-01	0.768000	2.04e-01	7.67e-12	2.75e-09
CITRIC ACID CYCLE TCA CYCLE	33	1.62e-20	1.32e-18	1.1500	0.155000	-8.86e-01	0.723000	1.23e-01	1.14e-18	6.56e-13
RESPIRATORY ELECTRON TRANSPORT	124	1.52e-74	4.56e-72	1.1400	0.206000	-8.43e-01	0.734000	7.71e-05	1.76e-59	2.20e-45
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	8.22e-19	5.28e-17	1.1100	0.055800	-8.24e-01	0.739000	5.79e-01	2.49e-16	2.01e-13
UBIQUINOL BIOSYNTHESIS	11	6.39e-07	8.21e-06	1.1000	-0.292000	-8.75e-01	0.602000	9.42e-02	5.03e-07	5.47e-04
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE	18	3.45e-10	7.05e-09	1.1000	0.096500	-8.29e-01	0.718000	4.78e-01	1.12e-09	1.34e-07
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	10	2.10e-05	1.80e-04	1.0700	0.166000	-7.30e-01	0.761000	3.65e-01	6.33e-05	3.06e-05
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT	202	1.78e-101	1.60e-98	1.0400	0.176000	-7.86e-01	0.653000	1.65e-05	3.09e-83	8.16e-58
MITOCHONDRIAL TRANSLATION	87	7.76e-43	1.75e-40	1.0300	0.038300	-7.77e-01	0.670000	5.37e-01	3.76e-36	2.88e-27
CROSSLINKING OF COLLAGEN FIBRILS	18	6.68e-09	1.16e-07	1.0300	-0.340000	6.92e-01	-0.676000	1.25e-02	3.64e-07	6.88e-07
MITOCHONDRIAL PROTEIN DEGRADATION	70	5.27e-32	5.27e-30	0.9890	0.066100	-7.61e-01	0.628000	3.39e-01	2.72e-28	9.87e-20
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	5.66e-05	3.92e-04	0.9700	0.016900	-6.70e-01	0.701000	9.22e-01	1.18e-04	5.73e-05
COMPLEX IV ASSEMBLY	38	1.80e-16	7.72e-15	0.9660	0.226000	-7.09e-01	0.616000	1.59e-02	3.85e-14	4.88e-11
COLLAGEN CHAIN TRIMERIZATION	34	9.66e-15	3.34e-13	0.9360	-0.340000	7.33e-01	-0.472000	6.05e-04	1.31e-13	1.93e-06
HEME BIOSYNTHESIS	12	4.81e-05	3.55e-04	0.9290	-0.059100	-6.82e-01	0.629000	7.23e-01	4.34e-05	1.61e-04
NCAM1 INTERACTIONS	16	6.12e-07	7.98e-06	0.9220	-0.501000	6.19e-01	-0.465000	5.23e-04	1.80e-05	1.28e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	14	1.20e-05	1.11e-04	0.9210	0.181000	-6.79e-01	0.596000	2.40e-01	1.08e-05	1.14e-04
NON INTEGRIN MEMBRANE ECM INTERACTIONS	30	4.35e-11	1.03e-09	0.8810	-0.343000	6.12e-01	-0.534000	1.16e-03	6.50e-09	4.18e-07
MITOCHONDRIAL BIOGENESIS	10	5.26e-04	2.50e-03	0.8790	0.141000	-7.38e-01	0.456000	4.39e-01	5.36e-05	1.25e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	10	5.26e-04	2.50e-03	0.8790	0.141000	-7.38e-01	0.456000	4.39e-01	5.36e-05	1.25e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	14	3.41e-05	2.65e-04	0.8740	0.003000	-5.55e-01	0.675000	9.84e-01	3.27e-04	1.21e-05
MET ACTIVATES PTK2 SIGNALING	18	2.00e-06	2.28e-05	0.8550	-0.192000	6.81e-01	-0.481000	1.59e-01	5.66e-07	4.14e-04
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	53	1.82e-18	1.09e-16	0.8500	-0.272000	6.59e-01	-0.462000	6.11e-04	9.90e-17	6.11e-09
ER PHAGOSOME PATHWAY	19	4.73e-07	6.55e-06	0.8350	-0.518000	3.41e-01	-0.560000	9.27e-05	1.01e-02	2.38e-05
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	42	3.37e-14	1.12e-12	0.8310	-0.366000	6.02e-01	-0.440000	4.11e-05	1.45e-11	8.07e-07
ECM PROTEOGLYCANS	35	8.08e-12	2.03e-10	0.8270	-0.303000	6.42e-01	-0.425000	1.96e-03	4.73e-11	1.36e-05
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	11	1.31e-03	5.19e-03	0.8160	-0.190000	5.29e-01	-0.591000	2.76e-01	2.36e-03	6.94e-04
LAMININ INTERACTIONS	15	3.98e-05	3.04e-04	0.8140	-0.294000	6.47e-01	-0.396000	4.88e-02	1.42e-05	7.89e-03
CHONDROITIN SULFATE BIOSYNTHESIS	16	5.08e-05	3.63e-04	0.8020	-0.205000	6.12e-01	-0.477000	1.55e-01	2.27e-05	9.57e-04
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	10	3.85e-03	1.27e-02	0.7900	0.073800	-5.86e-01	0.524000	6.86e-01	1.33e-03	4.10e-03
COLLAGEN FORMATION	65	2.33e-19	1.75e-17	0.7880	-0.290000	5.86e-01	-0.439000	5.16e-05	3.06e-16	9.21e-10
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	11	2.12e-03	7.84e-03	0.7560	-0.444000	4.69e-01	-0.392000	1.08e-02	7.03e-03	2.45e-02
METABOLISM OF COFACTORS	23	1.23e-06	1.46e-05	0.7520	-0.109000	-6.23e-01	0.408000	3.64e-01	2.35e-07	7.14e-04
ELASTIC FIBRE FORMATION	36	1.41e-09	2.58e-08	0.7330	-0.148000	6.10e-01	-0.379000	1.24e-01	2.34e-10	8.43e-05
PEROXISOMAL PROTEIN IMPORT	61	4.08e-15	1.47e-13	0.7250	0.012600	-5.66e-01	0.454000	8.65e-01	2.03e-14	8.93e-10
CS DS DEGRADATION	11	4.53e-04	2.23e-03	0.7170	-0.243000	6.70e-01	-0.075800	1.64e-01	1.18e-04	6.63e-01
AFLATOXIN ACTIVATION AND DETOXIFICATION	10	7.47e-03	2.13e-02	0.7100	-0.096400	-3.65e-01	0.602000	5.98e-01	4.56e-02	9.84e-04
SYNDECAN INTERACTIONS	14	1.45e-03	5.64e-03	0.7070	-0.311000	4.19e-01	-0.476000	4.42e-02	6.59e-03	2.02e-03
BIOTIN TRANSPORT AND METABOLISM	11	4.98e-03	1.54e-02	0.7040	-0.223000	-4.23e-01	0.516000	2.01e-01	1.50e-02	3.05e-03
SULFUR AMINO ACID METABOLISM	19	1.33e-04	8.06e-04	0.7030	-0.051300	-4.88e-01	0.504000	6.99e-01	2.34e-04	1.42e-04
PYRUVATE METABOLISM	42	7.20e-10	1.38e-08	0.6970	0.106000	-5.69e-01	0.388000	2.33e-01	1.71e-10	1.38e-05
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	29	4.95e-07	6.75e-06	0.6930	-0.143000	5.84e-01	-0.345000	1.84e-01	5.33e-08	1.32e-03
PEROXISOMAL LIPID METABOLISM	27	3.82e-06	4.04e-05	0.6890	-0.037200	-4.72e-01	0.501000	7.38e-01	2.23e-05	6.66e-06
MITOTIC TELOPHASE CYTOKINESIS	13	1.07e-04	6.76e-04	0.6870	0.125000	4.66e-02	-0.674000	4.36e-01	7.71e-01	2.55e-05
INTEGRIN CELL SURFACE INTERACTIONS	65	3.82e-14	1.23e-12	0.6790	-0.250000	4.76e-01	-0.415000	4.87e-04	3.14e-11	7.40e-09
GENERATION OF SECOND MESSENGER MOLECULES	12	2.17e-04	1.19e-03	0.6770	-0.518000	-1.80e-01	-0.396000	1.89e-03	2.81e-01	1.74e-02
COHESIN LOADING ONTO CHROMATIN	10	4.81e-04	2.34e-03	0.6720	0.270000	-9.84e-02	-0.607000	1.40e-01	5.90e-01	8.86e-04
ESTABLISHMENT OF SISTER CHROMATID COHESION	10	1.10e-03	4.47e-03	0.6590	0.067700	-2.65e-02	-0.655000	7.11e-01	8.85e-01	3.34e-04
DISSOLUTION OF FIBRIN CLOT	10	1.37e-03	5.40e-03	0.6590	-0.313000	5.78e-01	0.051300	8.66e-02	1.56e-03	7.79e-01
METABOLISM OF PORPHYRINS	21	1.58e-04	9.18e-04	0.6580	-0.089200	-4.83e-01	0.438000	4.79e-01	1.29e-04	5.07e-04
LYSINE CATABOLISM	10	2.01e-02	4.88e-02	0.6570	-0.118000	-4.01e-01	0.507000	5.19e-01	2.82e-02	5.50e-03
REGULATION OF PYRUVATE METABOLISM	32	5.04e-07	6.78e-06	0.6530	0.154000	-5.55e-01	0.308000	1.32e-01	5.38e-08	2.59e-03
CARNITINE METABOLISM	14	2.43e-03	8.71e-03	0.6500	-0.091100	-5.67e-01	0.304000	5.55e-01	2.39e-04	4.92e-02
COLLAGEN DEGRADATION	39	2.82e-08	4.61e-07	0.6480	-0.263000	5.03e-01	-0.312000	4.51e-03	5.60e-08	7.35e-04
MET PROMOTES CELL MOTILITY	28	1.40e-05	1.28e-04	0.6450	-0.173000	4.75e-01	-0.400000	1.12e-01	1.37e-05	2.45e-04
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	14	2.29e-03	8.39e-03	0.6400	-0.282000	-3.20e-01	0.477000	6.77e-02	3.80e-02	2.02e-03
KERATAN SULFATE DEGRADATION	12	2.47e-03	8.80e-03	0.6360	0.024300	6.20e-01	-0.140000	8.84e-01	2.00e-04	4.00e-01
CYTOPROTECTION BY HMOX1	44	7.26e-09	1.23e-07	0.6300	0.256000	-4.92e-01	0.297000	3.30e-03	1.60e-08	6.49e-04
ACYL CHAIN REMODELLING OF PE	15	8.74e-04	3.78e-03	0.6280	-0.297000	-2.13e-01	0.511000	4.66e-02	1.53e-01	6.17e-04
MITOCHONDRIAL CALCIUM ION TRANSPORT	14	3.01e-03	1.04e-02	0.6160	-0.372000	-3.84e-01	0.306000	1.59e-02	1.28e-02	4.77e-02
GLUCONEOGENESIS	19	7.27e-04	3.22e-03	0.6120	-0.228000	-3.94e-01	0.410000	8.51e-02	2.95e-03	1.99e-03
EXTRACELLULAR MATRIX ORGANIZATION	191	4.65e-34	5.98e-32	0.6120	-0.218000	4.59e-01	-0.341000	2.23e-07	8.54e-28	4.41e-16
PROTEIN LOCALIZATION	95	9.49e-17	4.50e-15	0.6090	-0.032800	-4.77e-01	0.378000	5.81e-01	9.60e-16	1.94e-10
ASPIRIN ADME	17	3.73e-04	1.87e-03	0.5990	-0.098000	-1.31e-01	0.576000	4.84e-01	3.50e-01	3.89e-05
DAP12 INTERACTIONS	31	6.94e-06	7.02e-05	0.5950	-0.385000	2.47e-01	-0.381000	2.08e-04	1.72e-02	2.45e-04
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	52	1.17e-10	2.46e-09	0.5950	-0.402000	1.42e-01	-0.415000	5.42e-07	7.69e-02	2.25e-07
PECAM1 INTERACTIONS	11	1.77e-02	4.35e-02	0.5950	-0.382000	1.71e-01	-0.422000	2.81e-02	3.25e-01	1.54e-02
PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	10	4.81e-03	1.50e-02	0.5950	-0.436000	-1.80e-01	-0.362000	1.69e-02	3.25e-01	4.77e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	40	4.52e-07	6.36e-06	0.5870	-0.257000	4.50e-01	-0.276000	4.95e-03	8.46e-07	2.55e-03
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	19	6.95e-04	3.13e-03	0.5860	-0.458000	3.10e-01	-0.194000	5.47e-04	1.94e-02	1.44e-01
INFLAMMASOMES	12	2.08e-02	5.01e-02	0.5840	-0.004830	2.80e-01	-0.513000	9.77e-01	9.33e-02	2.09e-03
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	18	1.79e-03	6.81e-03	0.5730	0.102000	-5.21e-01	0.215000	4.52e-01	1.29e-04	1.15e-01
CONDENSATION OF PROPHASE CHROMOSOMES	12	2.40e-02	5.61e-02	0.5720	-0.266000	2.35e-01	-0.448000	1.11e-01	1.59e-01	7.17e-03
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	10	8.55e-03	2.40e-02	0.5710	0.004630	5.71e-01	0.007440	9.80e-01	1.78e-03	9.67e-01
POLYMERASE SWITCHING	14	4.21e-03	1.36e-02	0.5700	0.383000	1.71e-01	-0.386000	1.30e-02	2.67e-01	1.25e-02
TRANSLATION	218	2.38e-33	2.67e-31	0.5690	-0.078700	-4.06e-01	0.390000	4.57e-02	4.98e-25	3.14e-23
ACTIVATION OF SMO	10	4.19e-02	8.61e-02	0.5680	0.228000	4.52e-01	-0.256000	2.11e-01	1.33e-02	1.60e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	26	6.07e-05	4.14e-04	0.5620	-0.355000	1.29e-01	-0.416000	1.75e-03	2.56e-01	2.42e-04
CHOLESTEROL BIOSYNTHESIS	26	4.10e-06	4.24e-05	0.5610	0.145000	-1.01e-02	0.542000	2.00e-01	9.29e-01	1.74e-06
VITAMIN B5 PANTOTHENATE METABOLISM	14	2.09e-02	5.01e-02	0.5580	-0.053400	-4.40e-01	0.340000	7.29e-01	4.40e-03	2.77e-02
PINK1 PRKN MEDIATED MITOPHAGY	30	9.15e-05	5.97e-04	0.5580	-0.077700	-4.50e-01	0.321000	4.61e-01	2.02e-05	2.35e-03
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	14	1.49e-02	3.82e-02	0.5560	-0.263000	4.30e-01	-0.235000	8.80e-02	5.40e-03	1.28e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	2.80e-02	6.38e-02	0.5540	-0.137000	-3.96e-01	0.363000	3.94e-01	1.35e-02	2.35e-02
RHO GTPASES ACTIVATE KTN1	10	3.88e-02	8.22e-02	0.5540	-0.493000	1.35e-01	-0.214000	6.99e-03	4.61e-01	2.41e-01
FATTY ACID METABOLISM	133	5.00e-19	3.46e-17	0.5510	-0.051300	-3.63e-01	0.410000	3.08e-01	4.72e-13	3.10e-16
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	2.29e-02	5.40e-02	0.5460	-0.228000	-2.21e-01	0.445000	1.72e-01	1.86e-01	7.65e-03
MITOPHAGY	37	2.01e-05	1.74e-04	0.5460	0.018000	-4.42e-01	0.321000	8.49e-01	3.31e-06	7.39e-04
RAP1 SIGNALLING	15	3.86e-03	1.27e-02	0.5440	-0.495000	-2.11e-01	0.077400	9.01e-04	1.57e-01	6.04e-01
RUNX3 REGULATES NOTCH SIGNALING	10	5.90e-02	1.13e-01	0.5400	0.201000	2.49e-01	-0.435000	2.71e-01	1.74e-01	1.72e-02
NUCLEOTIDE BIOSYNTHESIS	12	5.10e-02	1.00e-01	0.5400	0.056100	-3.06e-01	0.441000	7.37e-01	6.67e-02	8.15e-03
RECEPTOR MEDIATED MITOPHAGY	11	6.16e-02	1.15e-01	0.5370	0.201000	-4.23e-01	0.263000	2.48e-01	1.51e-02	1.31e-01
INITIAL TRIGGERING OF COMPLEMENT	13	1.04e-02	2.80e-02	0.5370	-0.509000	-1.38e-01	0.102000	1.50e-03	3.89e-01	5.24e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	7.88e-05	5.21e-04	0.5340	0.044600	2.46e-01	-0.472000	6.67e-01	1.79e-02	5.32e-06
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	6.92e-03	2.00e-02	0.5290	0.344000	1.61e-01	-0.368000	2.12e-02	2.81e-01	1.36e-02
REPRODUCTION	11	3.09e-02	6.97e-02	0.5280	0.176000	4.79e-01	-0.134000	3.13e-01	5.93e-03	4.40e-01
SIGNALING BY PDGF	50	3.37e-07	4.89e-06	0.5260	-0.334000	3.13e-01	-0.260000	4.36e-05	1.32e-04	1.49e-03
RHO GTPASES ACTIVATE WASPS AND WAVES	33	5.29e-05	3.75e-04	0.5260	-0.232000	2.00e-01	-0.428000	2.12e-02	4.72e-02	2.10e-05
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	14	2.49e-02	5.79e-02	0.5260	0.065800	-2.30e-01	0.468000	6.70e-01	1.36e-01	2.43e-03
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	5.33e-02	1.03e-01	0.5230	-0.294000	3.45e-01	-0.261000	7.82e-02	3.84e-02	1.18e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	7.57e-02	1.36e-01	0.5220	-0.322000	1.75e-01	-0.372000	7.82e-02	3.38e-01	4.15e-02
SIGNALING BY BMP	23	3.49e-03	1.19e-02	0.5140	-0.187000	3.87e-01	-0.282000	1.21e-01	1.31e-03	1.92e-02
HYALURONAN UPTAKE AND DEGRADATION	11	4.45e-02	9.03e-02	0.5120	-0.143000	4.74e-01	-0.132000	4.11e-01	6.51e-03	4.49e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	18	1.05e-03	4.32e-03	0.5120	-0.440000	-1.73e-01	-0.195000	1.22e-03	2.05e-01	1.52e-01
GPVI MEDIATED ACTIVATION CASCADE	29	2.67e-04	1.41e-03	0.5090	-0.395000	2.38e-01	-0.215000	2.28e-04	2.69e-02	4.49e-02
ANTIGEN PROCESSING CROSS PRESENTATION	72	8.13e-12	2.03e-10	0.5090	-0.480000	1.46e-02	-0.167000	1.84e-12	8.30e-01	1.44e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION	20	3.32e-03	1.14e-02	0.5080	-0.436000	1.80e-01	-0.190000	7.45e-04	1.62e-01	1.41e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	6.34e-03	1.87e-02	0.5080	-0.357000	3.30e-01	-0.147000	8.66e-03	1.54e-02	2.80e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	34	2.16e-04	1.19e-03	0.5070	-0.213000	2.78e-01	-0.366000	3.16e-02	4.97e-03	2.20e-04
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	6.68e-02	1.23e-01	0.5040	-0.403000	2.06e-01	-0.221000	2.05e-02	2.36e-01	2.04e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	79	9.25e-11	1.98e-09	0.5040	-0.213000	4.13e-01	-0.195000	1.05e-03	2.28e-10	2.71e-03
RETROGRADE NEUROTROPHIN SIGNALLING	10	4.53e-02	9.10e-02	0.5020	-0.476000	1.90e-02	0.158000	9.13e-03	9.17e-01	3.87e-01
TRIGLYCERIDE METABOLISM	12	2.85e-02	6.47e-02	0.5010	-0.307000	-3.83e-01	0.099000	6.54e-02	2.15e-02	5.53e-01
GLUTATHIONE CONJUGATION	32	2.44e-04	1.31e-03	0.4990	-0.021000	-2.32e-01	0.441000	8.37e-01	2.33e-02	1.58e-05
TRANSCRIPTIONAL REGULATION BY E2F6	23	1.85e-04	1.05e-03	0.4950	0.227000	1.02e-02	-0.440000	6.01e-02	9.32e-01	2.60e-04
ACYL CHAIN REMODELLING OF PG	10	7.44e-02	1.34e-01	0.4950	-0.391000	-2.14e-01	0.214000	3.23e-02	2.41e-01	2.40e-01
REGULATION OF KIT SIGNALING	12	6.12e-02	1.15e-01	0.4850	-0.205000	1.49e-01	-0.414000	2.18e-01	3.72e-01	1.30e-02
LAGGING STRAND SYNTHESIS	20	2.78e-03	9.75e-03	0.4850	0.277000	1.20e-01	-0.380000	3.20e-02	3.53e-01	3.26e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	30	2.43e-04	1.31e-03	0.4840	-0.329000	-2.07e-01	0.288000	1.84e-03	4.93e-02	6.33e-03
SIGNALING BY HIPPO	20	1.69e-02	4.22e-02	0.4830	-0.155000	3.55e-01	-0.289000	2.31e-01	6.04e-03	2.52e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	10	1.66e-02	4.17e-02	0.4800	0.254000	-2.43e-01	-0.326000	1.64e-01	1.84e-01	7.42e-02
ACYL CHAIN REMODELLING OF PC	17	1.92e-02	4.67e-02	0.4790	-0.159000	-2.19e-01	0.395000	2.56e-01	1.17e-01	4.77e-03
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	12	6.71e-02	1.23e-01	0.4790	-0.395000	1.84e-01	-0.199000	1.79e-02	2.69e-01	2.32e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	30	6.13e-05	4.15e-04	0.4760	-0.022400	4.87e-02	-0.473000	8.32e-01	6.44e-01	7.30e-06
ISG15 ANTIVIRAL MECHANISM	27	2.45e-04	1.31e-03	0.4750	-0.382000	-2.95e-02	-0.281000	5.94e-04	7.91e-01	1.16e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	10	1.56e-01	2.42e-01	0.4740	-0.233000	2.22e-01	-0.348000	2.03e-01	2.25e-01	5.68e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS	24	2.15e-03	7.93e-03	0.4730	-0.306000	-2.04e-01	0.298000	9.36e-03	8.44e-02	1.16e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	18	5.14e-03	1.58e-02	0.4720	-0.334000	3.33e-01	-0.009170	1.41e-02	1.45e-02	9.46e-01
SEMA3A PAK DEPENDENT AXON REPULSION	14	4.74e-02	9.48e-02	0.4690	-0.377000	2.08e-01	-0.185000	1.45e-02	1.78e-01	2.31e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	14	7.68e-02	1.37e-01	0.4690	-0.190000	3.36e-01	-0.266000	2.18e-01	2.97e-02	8.46e-02
PRC2 METHYLATES HISTONES AND DNA	15	6.56e-03	1.92e-02	0.4670	0.164000	-2.75e-02	-0.437000	2.72e-01	8.54e-01	3.41e-03
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	23	2.42e-03	8.71e-03	0.4660	0.324000	1.49e-01	-0.300000	7.10e-03	2.15e-01	1.27e-02
TP53 REGULATES METABOLIC GENES	66	6.50e-07	8.24e-06	0.4650	0.037500	-3.77e-01	0.271000	5.99e-01	1.21e-07	1.44e-04
REGULATION OF ENDOGENOUS RETROELEMENTS	28	2.04e-04	1.14e-03	0.4650	0.327000	4.77e-02	-0.327000	2.73e-03	6.62e-01	2.79e-03
CRMPS IN SEMA3A SIGNALING	14	8.42e-02	1.48e-01	0.4650	-0.189000	2.79e-01	-0.320000	2.22e-01	7.12e-02	3.79e-02
REGULATION OF FZD BY UBIQUITINATION	13	1.06e-02	2.85e-02	0.4640	0.283000	-3.36e-01	-0.147000	7.73e-02	3.57e-02	3.58e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	45	1.80e-06	2.08e-05	0.4630	-0.445000	-1.25e-01	0.008680	2.36e-07	1.48e-01	9.20e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	16	3.87e-03	1.27e-02	0.4600	-0.025200	4.54e-01	0.068700	8.61e-01	1.67e-03	6.34e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	83	5.16e-10	1.01e-08	0.4600	-0.260000	3.53e-01	-0.137000	4.33e-05	2.63e-08	3.13e-02
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	1.97e-04	1.11e-03	0.4590	0.074800	1.48e-01	-0.428000	4.51e-01	1.34e-01	1.59e-05
G BETA GAMMA SIGNALLING THROUGH CDC42	15	2.56e-02	5.91e-02	0.4580	-0.367000	2.50e-02	-0.272000	1.38e-02	8.67e-01	6.81e-02
OTHER INTERLEUKIN SIGNALING	14	6.51e-02	1.20e-01	0.4570	-0.266000	3.25e-01	-0.181000	8.50e-02	3.55e-02	2.40e-01
G PROTEIN ACTIVATION	15	1.57e-02	3.99e-02	0.4510	-0.378000	-1.08e-01	-0.222000	1.14e-02	4.69e-01	1.36e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	29	3.76e-03	1.25e-02	0.4510	-0.090300	-2.76e-01	0.345000	4.00e-01	1.02e-02	1.31e-03
AMINE LIGAND BINDING RECEPTORS	14	5.95e-02	1.13e-01	0.4500	-0.061000	-1.71e-01	0.412000	6.93e-01	2.69e-01	7.64e-03
GLUTATHIONE SYNTHESIS AND RECYCLING	11	5.29e-02	1.03e-01	0.4500	-0.374000	4.08e-02	0.246000	3.15e-02	8.15e-01	1.58e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	74	2.73e-07	4.10e-06	0.4460	-0.229000	2.43e-01	-0.296000	6.80e-04	2.99e-04	1.05e-05
SYNTHESIS OF PA	25	9.15e-03	2.53e-02	0.4450	-0.119000	-3.41e-01	0.260000	3.03e-01	3.18e-03	2.44e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	11	8.61e-02	1.51e-01	0.4450	-0.442000	-4.58e-02	0.024200	1.12e-02	7.93e-01	8.89e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	11	1.54e-01	2.39e-01	0.4410	0.184000	3.23e-01	-0.238000	2.91e-01	6.38e-02	1.71e-01
GLYCOGEN METABOLISM	17	4.79e-02	9.54e-02	0.4410	-0.166000	-3.13e-01	0.262000	2.35e-01	2.54e-02	6.10e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	13	1.13e-01	1.88e-01	0.4410	-0.116000	-3.51e-01	0.241000	4.69e-01	2.86e-02	1.33e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	14	4.80e-02	9.54e-02	0.4390	-0.372000	2.49e-02	-0.231000	1.60e-02	8.72e-01	1.34e-01
SIGNALING BY RETINOIC ACID	34	2.50e-03	8.89e-03	0.4390	-0.038200	-3.18e-01	0.300000	7.00e-01	1.33e-03	2.50e-03
GAP JUNCTION ASSEMBLY	18	2.12e-02	5.05e-02	0.4360	-0.346000	2.54e-01	-0.075300	1.11e-02	6.19e-02	5.81e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	31	7.08e-04	3.17e-03	0.4350	0.244000	1.29e-01	-0.337000	1.89e-02	2.14e-01	1.17e-03
TELOMERE C STRAND SYNTHESIS INITIATION	11	1.40e-01	2.22e-01	0.4350	0.258000	2.16e-01	-0.275000	1.38e-01	2.14e-01	1.14e-01
DNA STRAND ELONGATION	24	5.38e-03	1.63e-02	0.4330	0.170000	1.39e-01	-0.373000	1.49e-01	2.38e-01	1.55e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	11	2.17e-01	3.16e-01	0.4330	-0.086200	3.25e-01	-0.274000	6.21e-01	6.23e-02	1.16e-01
METAL ION SLC TRANSPORTERS	17	7.46e-03	2.13e-02	0.4310	-0.280000	-1.30e-01	-0.301000	4.55e-02	3.53e-01	3.17e-02
SEMA4D IN SEMAPHORIN SIGNALING	15	9.03e-03	2.50e-02	0.4310	-0.261000	2.96e-01	0.173000	8.07e-02	4.71e-02	2.47e-01
FCGR ACTIVATION	11	1.96e-01	2.92e-01	0.4300	-0.238000	2.21e-01	-0.282000	1.72e-01	2.05e-01	1.06e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	86	8.54e-08	1.32e-06	0.4280	-0.099500	-2.82e-01	0.307000	1.11e-01	6.48e-06	8.78e-07
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	11	2.12e-01	3.11e-01	0.4260	-0.047500	-2.56e-01	0.338000	7.85e-01	1.42e-01	5.25e-02
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	20	6.09e-03	1.80e-02	0.4250	-0.339000	-9.77e-02	-0.236000	8.62e-03	4.49e-01	6.75e-02
RHO GTPASES ACTIVATE PAKS	22	3.71e-03	1.25e-02	0.4230	-0.340000	2.44e-01	0.060100	5.72e-03	4.75e-02	6.26e-01
DEADENYLATION OF MRNA	22	5.05e-04	2.43e-03	0.4230	-0.149000	-2.07e-01	-0.337000	2.25e-01	9.32e-02	6.17e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	10	7.02e-02	1.28e-01	0.4230	-0.234000	-3.35e-01	-0.109000	2.00e-01	6.69e-02	5.52e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES	187	1.23e-16	5.54e-15	0.4230	-0.125000	-2.62e-01	0.307000	3.19e-03	7.08e-10	4.64e-13
BILE ACID AND BILE SALT METABOLISM	28	3.81e-03	1.27e-02	0.4200	-0.277000	-1.89e-01	0.254000	1.12e-02	8.43e-02	1.99e-02
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	37	2.41e-03	8.71e-03	0.4190	-0.069600	3.38e-01	-0.238000	4.64e-01	3.75e-04	1.22e-02
COMPLEMENT CASCADE	26	3.42e-03	1.17e-02	0.4180	-0.382000	-9.53e-02	0.142000	7.50e-04	4.01e-01	2.10e-01
SHC1 EVENTS IN EGFR SIGNALING	11	1.69e-01	2.58e-01	0.4180	-0.335000	2.07e-01	-0.140000	5.41e-02	2.34e-01	4.20e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	11	5.70e-02	1.10e-01	0.4170	-0.313000	2.02e-01	0.187000	7.19e-02	2.46e-01	2.82e-01
TRAF6 MEDIATED NF KB ACTIVATION	13	1.13e-01	1.89e-01	0.4170	-0.284000	2.79e-01	-0.124000	7.65e-02	8.12e-02	4.38e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	16	8.84e-03	2.46e-02	0.4170	-0.079400	-1.09e-01	-0.395000	5.83e-01	4.52e-01	6.26e-03
PLASMA LIPOPROTEIN ASSEMBLY	13	7.99e-02	1.42e-01	0.4160	-0.358000	-9.16e-02	0.191000	2.55e-02	5.68e-01	2.34e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	18	1.89e-02	4.62e-02	0.4150	-0.367000	-6.50e-02	-0.183000	7.01e-03	6.33e-01	1.80e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	4.31e-03	1.39e-02	0.4130	-0.293000	2.89e-01	0.024600	1.50e-02	1.63e-02	8.38e-01
O LINKED GLYCOSYLATION OF MUCINS	30	5.86e-03	1.74e-02	0.4120	-0.218000	1.57e-01	-0.313000	3.92e-02	1.37e-01	2.99e-03
KINESINS	47	1.06e-04	6.74e-04	0.4110	-0.228000	3.19e-01	-0.123000	6.85e-03	1.52e-04	1.45e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	16	9.49e-03	2.60e-02	0.4100	-0.009410	-3.96e-01	-0.107000	9.48e-01	6.12e-03	4.57e-01
RHOU GTPASE CYCLE	38	2.64e-03	9.28e-03	0.4100	-0.171000	2.29e-01	-0.294000	6.80e-02	1.44e-02	1.73e-03
HYALURONAN METABOLISM	14	6.97e-02	1.27e-01	0.4100	-0.062200	3.98e-01	-0.076600	6.87e-01	9.98e-03	6.20e-01
PI 3K CASCADE FGFR3	12	2.38e-02	5.57e-02	0.4090	-0.098400	-3.33e-01	-0.217000	5.55e-01	4.57e-02	1.93e-01
GROWTH HORMONE RECEPTOR SIGNALING	10	1.26e-01	2.05e-01	0.4090	-0.007080	-4.09e-01	0.019300	9.69e-01	2.53e-02	9.16e-01
VOLTAGE GATED POTASSIUM CHANNELS	21	5.82e-02	1.12e-01	0.4080	0.077700	-2.85e-01	0.282000	5.38e-01	2.37e-02	2.54e-02
CA DEPENDENT EVENTS	25	6.76e-03	1.96e-02	0.4080	-0.342000	2.45e-02	-0.220000	3.04e-03	8.32e-01	5.67e-02
AGGREPHAGY	28	4.60e-03	1.45e-02	0.4080	-0.263000	2.99e-01	-0.087000	1.58e-02	6.25e-03	4.26e-01
RHOV GTPASE CYCLE	34	4.09e-03	1.33e-02	0.4070	-0.218000	1.84e-01	-0.291000	2.80e-02	6.36e-02	3.34e-03
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	17	7.51e-02	1.35e-01	0.4070	-0.176000	1.56e-01	-0.332000	2.08e-01	2.66e-01	1.79e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	7.84e-02	1.40e-01	0.4060	-0.320000	2.50e-01	0.001610	4.60e-02	1.18e-01	9.92e-01
HDR THROUGH MMEJ ALT NHEJ	12	6.08e-02	1.14e-01	0.4050	-0.274000	-1.22e-01	-0.272000	9.97e-02	4.65e-01	1.03e-01
GLYCOSAMINOGLYCAN METABOLISM	98	2.74e-08	4.56e-07	0.4050	-0.169000	3.21e-01	-0.180000	3.89e-03	4.18e-08	2.13e-03
METALLOPROTEASE DUBS	17	3.75e-02	8.05e-02	0.4040	0.354000	7.41e-02	-0.181000	1.16e-02	5.97e-01	1.97e-01
SIGNALING BY TGFBR3	21	3.97e-02	8.31e-02	0.4040	-0.036700	3.61e-01	-0.176000	7.71e-01	4.16e-03	1.63e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	12	1.51e-01	2.35e-01	0.4020	0.243000	-8.65e-02	0.309000	1.46e-01	6.04e-01	6.43e-02
NUCLEAR SIGNALING BY ERBB4	11	1.39e-01	2.21e-01	0.4000	0.353000	3.42e-02	0.187000	4.29e-02	8.44e-01	2.84e-01
RAC2 GTPASE CYCLE	80	8.05e-07	1.01e-05	0.4000	-0.170000	1.57e-01	-0.326000	8.54e-03	1.55e-02	4.57e-07
TRANSLESION SYNTHESIS BY POLK	17	2.05e-02	4.95e-02	0.3990	0.193000	-9.43e-03	-0.349000	1.69e-01	9.46e-01	1.27e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	11	1.74e-01	2.64e-01	0.3980	-0.137000	-1.20e-01	0.354000	4.31e-01	4.92e-01	4.19e-02
PLATELET AGGREGATION PLUG FORMATION	30	5.28e-03	1.61e-02	0.3980	-0.246000	2.93e-01	-0.109000	1.99e-02	5.48e-03	3.02e-01
REGULATION OF PTEN GENE TRANSCRIPTION	27	9.23e-03	2.54e-02	0.3970	-0.159000	-3.36e-01	0.141000	1.53e-01	2.51e-03	2.05e-01
METABOLISM OF STEROID HORMONES	15	6.04e-02	1.14e-01	0.3970	0.135000	-3.96e-02	0.371000	3.66e-01	7.90e-01	1.28e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	16	3.46e-02	7.64e-02	0.3970	-0.328000	-1.02e-01	-0.199000	2.32e-02	4.82e-01	1.69e-01
REGULATION OF NF KAPPA B SIGNALING	16	1.57e-02	3.99e-02	0.3960	-0.213000	-1.61e-01	-0.292000	1.40e-01	2.64e-01	4.31e-02
EPHB MEDIATED FORWARD SIGNALING	35	5.16e-03	1.58e-02	0.3950	-0.208000	1.81e-01	-0.283000	3.35e-02	6.44e-02	3.81e-03
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	15	6.22e-02	1.16e-01	0.3940	-0.362000	1.54e-01	0.022900	1.52e-02	3.00e-01	8.78e-01
MTORC1 MEDIATED SIGNALLING	24	1.35e-02	3.50e-02	0.3940	-0.111000	-3.63e-01	0.105000	3.46e-01	2.06e-03	3.72e-01
P75NTR SIGNALS VIA NF KB	16	1.45e-01	2.27e-01	0.3930	0.012900	3.00e-01	-0.253000	9.29e-01	3.77e-02	7.94e-02
PLATELET SENSITIZATION BY LDL	16	6.16e-02	1.15e-01	0.3930	-0.344000	-1.00e-01	0.161000	1.73e-02	4.88e-01	2.65e-01
TRP CHANNELS	15	8.80e-02	1.53e-01	0.3910	-0.253000	5.75e-02	-0.292000	8.97e-02	7.00e-01	5.02e-02
HSF1 DEPENDENT TRANSACTIVATION	23	1.04e-02	2.80e-02	0.3910	-0.009970	-4.97e-02	0.387000	9.34e-01	6.80e-01	1.31e-03
KERATAN SULFATE BIOSYNTHESIS	21	7.69e-02	1.37e-01	0.3900	-0.035100	2.64e-01	-0.286000	7.81e-01	3.64e-02	2.35e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	22	6.01e-02	1.14e-01	0.3900	-0.175000	2.31e-01	-0.260000	1.55e-01	6.06e-02	3.46e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	23	3.87e-02	8.21e-02	0.3890	0.059500	1.90e-01	-0.333000	6.21e-01	1.14e-01	5.64e-03
ERBB2 REGULATES CELL MOTILITY	12	9.98e-02	1.71e-01	0.3860	-0.333000	1.66e-01	0.102000	4.59e-02	3.20e-01	5.40e-01
G0 AND EARLY G1	16	2.32e-02	5.48e-02	0.3850	-0.112000	-8.57e-02	-0.358000	4.40e-01	5.53e-01	1.31e-02
INTERLEUKIN 15 SIGNALING	10	1.45e-01	2.27e-01	0.3850	0.030600	-3.83e-01	-0.014900	8.67e-01	3.59e-02	9.35e-01
ACYL CHAIN REMODELLING OF PS	14	1.06e-01	1.80e-01	0.3840	-0.301000	-1.04e-01	0.216000	5.15e-02	5.02e-01	1.62e-01
PURINE SALVAGE	11	1.69e-01	2.58e-01	0.3840	0.378000	-3.75e-02	-0.055500	2.98e-02	8.29e-01	7.50e-01
HS GAG BIOSYNTHESIS	21	3.61e-02	7.85e-02	0.3840	-0.350000	1.17e-01	-0.106000	5.51e-03	3.54e-01	4.01e-01
PI 3K CASCADE FGFR4	12	5.14e-02	1.01e-01	0.3820	-0.117000	-3.33e-01	-0.147000	4.83e-01	4.57e-02	3.79e-01
G PROTEIN BETA GAMMA SIGNALLING	27	4.55e-03	1.44e-02	0.3820	-0.295000	-4.82e-02	-0.239000	8.05e-03	6.65e-01	3.19e-02
PI 3K CASCADE FGFR2	13	3.83e-02	8.16e-02	0.3820	-0.137000	-3.19e-01	-0.159000	3.91e-01	4.66e-02	3.20e-01
INTERFERON ALPHA BETA SIGNALING	19	5.52e-02	1.07e-01	0.3800	-0.176000	8.51e-02	-0.326000	1.85e-01	5.21e-01	1.39e-02
RECYCLING PATHWAY OF L1	33	5.87e-03	1.74e-02	0.3800	-0.301000	1.96e-01	-0.122000	2.74e-03	5.11e-02	2.25e-01
POST NMDA RECEPTOR ACTIVATION EVENTS	14	1.26e-01	2.05e-01	0.3800	-0.352000	5.36e-02	-0.132000	2.26e-02	7.28e-01	3.93e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	3.59e-01	4.58e-01	0.3790	0.012700	-3.12e-01	0.215000	9.44e-01	8.76e-02	2.39e-01
LGI ADAM INTERACTIONS	10	2.77e-01	3.77e-01	0.3790	-0.063700	-1.33e-01	0.349000	7.27e-01	4.66e-01	5.61e-02
INTERLEUKIN 6 FAMILY SIGNALING	16	1.33e-01	2.14e-01	0.3780	-0.271000	1.70e-01	-0.201000	6.05e-02	2.40e-01	1.65e-01
PYROPTOSIS	16	1.05e-01	1.78e-01	0.3770	-0.292000	2.18e-01	-0.098100	4.35e-02	1.31e-01	4.97e-01
GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME	54	2.92e-05	2.33e-04	0.3760	-0.342000	-1.56e-01	0.012900	1.39e-05	4.75e-02	8.70e-01
MISMATCH REPAIR MMR DIRECTED BY MSH2 MSH3 MUTSBETA	10	1.43e-01	2.24e-01	0.3750	0.287000	-1.27e-01	-0.206000	1.16e-01	4.85e-01	2.60e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	1.34e-01	2.15e-01	0.3740	0.077500	-3.60e-01	-0.065100	6.71e-01	4.86e-02	7.22e-01
GPER1 SIGNALING	22	4.20e-02	8.61e-02	0.3740	-0.284000	8.98e-02	-0.226000	2.12e-02	4.66e-01	6.69e-02
RAC3 GTPASE CYCLE	82	5.39e-06	5.51e-05	0.3730	-0.122000	1.60e-01	-0.314000	5.65e-02	1.24e-02	8.69e-07
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	24	2.03e-02	4.92e-02	0.3730	-0.269000	3.38e-02	-0.256000	2.26e-02	7.74e-01	2.97e-02
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	11	6.75e-02	1.24e-01	0.3730	-0.001070	-1.66e-01	-0.334000	9.95e-01	3.39e-01	5.53e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	19	3.72e-02	8.03e-02	0.3720	-0.342000	-8.31e-02	-0.121000	9.87e-03	5.31e-01	3.61e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	11	8.54e-02	1.50e-01	0.3720	-0.195000	-2.44e-01	-0.202000	2.64e-01	1.61e-01	2.46e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	34	5.46e-04	2.56e-03	0.3720	0.089500	3.60e-01	0.027700	3.67e-01	2.82e-04	7.80e-01
INTEGRIN SIGNALING	26	2.10e-02	5.03e-02	0.3710	-0.242000	2.65e-01	-0.093000	3.28e-02	1.93e-02	4.12e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	11	2.07e-01	3.06e-01	0.3700	-0.118000	-8.35e-02	0.341000	4.98e-01	6.32e-01	5.02e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	18	7.43e-03	2.13e-02	0.3690	-0.044100	-2.83e-01	-0.234000	7.46e-01	3.78e-02	8.63e-02
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	18	4.48e-02	9.05e-02	0.3690	0.182000	4.13e-02	-0.318000	1.80e-01	7.62e-01	1.95e-02
INTRINSIC PATHWAY FOR APOPTOSIS	34	2.51e-03	8.89e-03	0.3680	-0.291000	-8.46e-03	-0.226000	3.34e-03	9.32e-01	2.25e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	17	8.77e-02	1.53e-01	0.3680	-0.324000	4.43e-02	-0.170000	2.08e-02	7.52e-01	2.26e-01
FRS MEDIATED FGFR3 SIGNALING	13	4.53e-02	9.10e-02	0.3680	-0.013400	-3.38e-01	-0.146000	9.33e-01	3.51e-02	3.62e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	16	1.08e-01	1.82e-01	0.3670	-0.286000	5.41e-02	-0.224000	4.78e-02	7.08e-01	1.20e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	10	3.33e-01	4.34e-01	0.3670	-0.189000	-2.50e-01	0.190000	3.01e-01	1.71e-01	2.98e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	26	9.74e-03	2.66e-02	0.3670	0.115000	4.64e-02	-0.345000	3.11e-01	6.82e-01	2.33e-03
PARACETAMOL ADME	20	5.15e-02	1.01e-01	0.3660	-0.072200	-9.82e-02	0.345000	5.76e-01	4.47e-01	7.53e-03
UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A	49	1.47e-04	8.75e-04	0.3660	-0.330000	-1.57e-01	0.018400	6.46e-05	5.70e-02	8.24e-01
RAC1 GTPASE CYCLE	162	5.21e-11	1.17e-09	0.3660	-0.171000	1.59e-01	-0.281000	1.74e-04	5.02e-04	6.76e-10
NUCLEAR EVENTS MEDIATED BY NFE2L2	53	9.31e-05	6.03e-04	0.3650	-0.325000	-1.56e-01	0.058500	4.19e-05	5.01e-02	4.62e-01
AQUAPORIN MEDIATED TRANSPORT	25	8.53e-03	2.40e-02	0.3650	-0.276000	-2.34e-01	-0.051200	1.71e-02	4.25e-02	6.58e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	54	5.98e-05	4.11e-04	0.3650	-0.344000	-1.22e-01	0.006900	1.21e-05	1.22e-01	9.30e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	2.30e-01	3.28e-01	0.3640	-0.100000	-3.48e-01	0.039500	5.84e-01	5.68e-02	8.29e-01
JOSEPHIN DOMAIN DUBS	10	1.96e-01	2.91e-01	0.3640	0.123000	-3.42e-01	-0.011300	5.01e-01	6.08e-02	9.51e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	2.06e-03	7.65e-03	0.3630	0.010800	7.10e-02	-0.356000	9.10e-01	4.55e-01	1.82e-04
TNFR2 NON CANONICAL NF KB PATHWAY	75	3.37e-06	3.61e-05	0.3630	-0.337000	3.94e-02	-0.128000	4.51e-07	5.56e-01	5.58e-02
PKA MEDIATED PHOSPHORYLATION OF CREB	16	8.15e-02	1.44e-01	0.3620	-0.336000	-1.27e-01	-0.045600	2.00e-02	3.78e-01	7.52e-01
GAP JUNCTION TRAFFICKING AND REGULATION	30	1.39e-02	3.57e-02	0.3620	-0.239000	2.55e-01	-0.093000	2.36e-02	1.55e-02	3.78e-01
DEGRADATION OF AXIN	52	9.90e-05	6.37e-04	0.3620	-0.342000	-1.17e-01	-0.012200	2.01e-05	1.45e-01	8.79e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	22	1.86e-02	4.56e-02	0.3610	-0.294000	-1.93e-01	-0.078100	1.68e-02	1.17e-01	5.26e-01
KERATAN SULFATE KERATIN METABOLISM	28	3.74e-02	8.04e-02	0.3610	-0.047000	3.10e-01	-0.178000	6.67e-01	4.51e-03	1.04e-01
CELLULAR RESPONSE TO HYPOXIA	65	1.43e-05	1.30e-04	0.3590	-0.319000	-1.55e-01	0.059400	8.99e-06	3.05e-02	4.08e-01
CELLULAR HEXOSE TRANSPORT	13	1.17e-01	1.93e-01	0.3580	-0.138000	-5.46e-03	0.330000	3.88e-01	9.73e-01	3.96e-02
HS GAG DEGRADATION	19	6.68e-02	1.23e-01	0.3570	-0.265000	2.36e-01	-0.043300	4.58e-02	7.49e-02	7.44e-01
ANTIMICROBIAL PEPTIDES	11	2.29e-01	3.28e-01	0.3570	-0.353000	3.07e-02	0.044300	4.26e-02	8.60e-01	7.99e-01
DEGRADATION OF DVL	53	1.48e-04	8.76e-04	0.3560	-0.309000	-1.69e-01	0.052000	1.00e-04	3.32e-02	5.13e-01
RESOLUTION OF D LOOP STRUCTURES	29	4.01e-02	8.37e-02	0.3560	-0.010400	1.96e-01	-0.297000	9.23e-01	6.82e-02	5.63e-03
MTOR SIGNALLING	41	4.85e-03	1.50e-02	0.3550	-0.107000	-2.97e-01	0.162000	2.36e-01	9.90e-04	7.35e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	50	2.64e-04	1.41e-03	0.3550	-0.323000	-1.41e-01	0.042000	7.87e-05	8.48e-02	6.08e-01
PHASE II CONJUGATION OF COMPOUNDS	69	5.56e-05	3.89e-04	0.3540	-0.148000	-1.60e-01	0.279000	3.34e-02	2.18e-02	6.07e-05
ACTIVATION OF MATRIX METALLOPROTEINASES	19	1.60e-02	4.04e-02	0.3540	-0.149000	2.92e-01	0.133000	2.61e-01	2.75e-02	3.15e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	90	3.79e-07	5.42e-06	0.3540	-0.285000	-1.87e-01	0.093100	3.00e-06	2.13e-03	1.27e-01
METABOLISM	1435	5.10e-79	2.30e-76	0.3530	-0.056200	-2.35e-01	0.257000	4.44e-04	5.07e-49	1.19e-58
OVARIAN TUMOR DOMAIN PROTEASES	31	1.70e-02	4.23e-02	0.3520	-0.146000	9.90e-02	-0.304000	1.59e-01	3.40e-01	3.36e-03
P75NTR RECRUITS SIGNALLING COMPLEXES	13	2.87e-01	3.88e-01	0.3520	0.116000	2.26e-01	-0.243000	4.69e-01	1.58e-01	1.29e-01
RHO GTPASES ACTIVATE IQGAPS	26	3.13e-02	7.04e-02	0.3520	-0.310000	1.43e-01	-0.085900	6.25e-03	2.07e-01	4.48e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	41	1.19e-03	4.80e-03	0.3520	-0.241000	2.55e-01	-0.016800	7.54e-03	4.72e-03	8.53e-01
INTRAFLAGELLAR TRANSPORT	40	1.82e-03	6.87e-03	0.3490	-0.087700	3.34e-01	-0.052100	3.37e-01	2.60e-04	5.69e-01
FRS MEDIATED FGFR4 SIGNALING	13	8.59e-02	1.50e-01	0.3490	-0.030600	-3.38e-01	-0.081300	8.49e-01	3.51e-02	6.12e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	24	5.96e-02	1.13e-01	0.3480	0.253000	-2.03e-01	0.127000	3.17e-02	8.55e-02	2.83e-01
RHO GTPASE EFFECTORS	217	1.08e-13	3.24e-12	0.3480	-0.247000	1.63e-01	-0.184000	4.04e-10	3.56e-05	3.32e-06
CYTOSOLIC SULFONATION OF SMALL MOLECULES	12	2.21e-01	3.19e-01	0.3470	-0.337000	-8.26e-02	0.004750	4.35e-02	6.20e-01	9.77e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	14	1.16e-01	1.92e-01	0.3460	-0.270000	-9.27e-02	-0.196000	7.99e-02	5.48e-01	2.05e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	17	1.01e-01	1.72e-01	0.3460	0.239000	-2.49e-01	0.028100	8.86e-02	7.58e-02	8.41e-01
SHC MEDIATED CASCADE FGFR3	11	1.03e-01	1.76e-01	0.3450	-0.098300	-2.07e-01	-0.259000	5.72e-01	2.36e-01	1.37e-01
STRIATED MUSCLE CONTRACTION	29	9.23e-04	3.92e-03	0.3450	-0.091200	1.85e-01	0.276000	3.95e-01	8.50e-02	9.99e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	19	1.32e-02	3.47e-02	0.3450	-0.073700	-2.76e-01	-0.193000	5.78e-01	3.75e-02	1.45e-01
PROCESSING OF INTRONLESS PRE MRNAS	20	8.58e-03	2.40e-02	0.3440	-0.024400	-2.54e-01	-0.232000	8.50e-01	4.97e-02	7.27e-02
TERMINATION OF TRANSLESION DNA SYNTHESIS	31	9.03e-03	2.50e-02	0.3440	0.069300	5.57e-02	-0.332000	5.04e-01	5.91e-01	1.38e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	18	1.75e-02	4.33e-02	0.3440	-0.056500	-2.83e-01	-0.187000	6.78e-01	3.78e-02	1.70e-01
NEGATIVE REGULATION OF FLT3	13	3.23e-01	4.23e-01	0.3430	-0.028900	1.83e-01	-0.289000	8.57e-01	2.55e-01	7.10e-02
FRS MEDIATED FGFR2 SIGNALING	14	7.01e-02	1.28e-01	0.3430	-0.055700	-3.24e-01	-0.097700	7.18e-01	3.59e-02	5.27e-01
AMINO ACIDS REGULATE MTORC1	46	9.43e-03	2.59e-02	0.3420	0.056000	-2.29e-01	0.248000	5.11e-01	7.32e-03	3.63e-03
HEDGEHOG LIGAND BIOGENESIS	56	1.37e-04	8.30e-04	0.3420	-0.322000	-1.13e-01	-0.018400	3.06e-05	1.44e-01	8.12e-01
GLYCOSPHINGOLIPID BIOSYNTHESIS	14	8.66e-02	1.51e-01	0.3420	-0.187000	2.69e-01	0.097200	2.25e-01	8.16e-02	5.29e-01
LDL CLEARANCE	15	1.40e-01	2.22e-01	0.3410	-0.332000	6.45e-02	0.045800	2.59e-02	6.66e-01	7.59e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	17	1.76e-01	2.66e-01	0.3410	-0.258000	1.58e-01	-0.158000	6.56e-02	2.59e-01	2.60e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	3.27e-04	1.66e-03	0.3410	-0.338000	-4.14e-02	-0.021500	2.13e-05	6.02e-01	7.87e-01
METABOLISM OF FAT SOLUBLE VITAMINS	31	1.25e-02	3.32e-02	0.3400	-0.309000	1.42e-01	-0.009680	2.91e-03	1.70e-01	9.26e-01
GAB1 SIGNALOSOME	15	1.88e-01	2.82e-01	0.3400	-0.301000	1.36e-01	-0.079300	4.37e-02	3.61e-01	5.95e-01
METABOLISM OF STEROIDS	80	2.53e-06	2.74e-05	0.3390	0.023300	-4.84e-02	0.335000	7.19e-01	4.55e-01	2.29e-07
DARPP 32 EVENTS	15	2.61e-01	3.62e-01	0.3370	-0.036300	-2.86e-01	0.175000	8.08e-01	5.49e-02	2.41e-01
TELOMERE MAINTENANCE	47	9.43e-04	3.98e-03	0.3370	0.183000	6.87e-02	-0.274000	2.99e-02	4.15e-01	1.15e-03
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	14	2.19e-01	3.18e-01	0.3370	0.154000	2.80e-01	-0.106000	3.18e-01	6.96e-02	4.94e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	27	2.64e-02	6.05e-02	0.3360	-0.329000	-6.45e-02	0.019100	3.09e-03	5.62e-01	8.64e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	10	3.82e-01	4.79e-01	0.3350	0.108000	1.19e-01	-0.294000	5.53e-01	5.15e-01	1.07e-01
NONSENSE MEDIATED DECAY NMD INDEPENDENT OF THE EXON JUNCTION COMPLEX EJC	88	9.95e-06	9.52e-05	0.3350	-0.118000	-1.37e-01	0.282000	5.60e-02	2.68e-02	4.80e-06
METABOLISM OF POLYAMINES	54	3.66e-04	1.85e-03	0.3350	-0.319000	-9.78e-02	0.026900	4.98e-05	2.14e-01	7.32e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	15	2.30e-01	3.28e-01	0.3340	-0.021100	1.24e-01	-0.309000	8.88e-01	4.04e-01	3.80e-02
TGFBR3 PTM REGULATION	10	3.73e-01	4.73e-01	0.3340	0.115000	2.97e-01	-0.099700	5.30e-01	1.04e-01	5.85e-01
SHC1 EVENTS IN ERBB2 SIGNALING	13	1.33e-01	2.14e-01	0.3330	-0.151000	2.91e-01	0.060900	3.46e-01	6.94e-02	7.04e-01
G PROTEIN MEDIATED EVENTS	36	1.48e-02	3.78e-02	0.3320	-0.274000	9.39e-02	-0.163000	4.45e-03	3.30e-01	9.16e-02
STABILIZATION OF P53	52	4.73e-04	2.32e-03	0.3320	-0.308000	-1.22e-01	-0.005200	1.20e-04	1.28e-01	9.48e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	68	6.39e-05	4.29e-04	0.3320	-0.329000	1.89e-02	-0.041500	2.81e-06	7.88e-01	5.54e-01
CD28 DEPENDENT VAV1 PATHWAY	11	3.41e-01	4.43e-01	0.3310	-0.289000	1.44e-01	-0.072800	9.70e-02	4.08e-01	6.76e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	2.27e-01	3.27e-01	0.3300	0.273000	-7.27e-02	-0.171000	1.17e-01	6.76e-01	3.28e-01
SIGNALING BY MET	61	2.28e-03	8.39e-03	0.3300	-0.135000	2.14e-01	-0.212000	6.93e-02	3.82e-03	4.24e-03
VXPX CARGO TARGETING TO CILIUM	17	2.05e-01	3.04e-01	0.3300	-0.096500	1.27e-01	-0.289000	4.91e-01	3.64e-01	3.94e-02
SEMAPHORIN INTERACTIONS	50	1.20e-03	4.82e-03	0.3280	-0.229000	2.31e-01	-0.043200	5.14e-03	4.68e-03	5.97e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	5.88e-04	2.71e-03	0.3280	-0.307000	-1.13e-01	0.024800	1.12e-04	1.53e-01	7.55e-01
ARACHIDONIC ACID METABOLISM	33	7.56e-03	2.14e-02	0.3280	-0.243000	-6.99e-03	0.220000	1.59e-02	9.45e-01	2.85e-02
RHOH GTPASE CYCLE	31	1.88e-02	4.60e-02	0.3270	-0.326000	-1.55e-02	-0.023600	1.67e-03	8.81e-01	8.20e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	10	4.87e-01	5.79e-01	0.3270	0.032700	2.67e-01	-0.186000	8.58e-01	1.43e-01	3.09e-01
REDUCTION OF CYTOSOLIC CA LEVELS	12	1.37e-01	2.19e-01	0.3270	-0.166000	-1.69e-01	-0.225000	3.20e-01	3.12e-01	1.76e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	30	3.81e-02	8.14e-02	0.3260	-0.125000	-2.73e-01	0.127000	2.36e-01	9.55e-03	2.28e-01
SHC1 EVENTS IN ERBB4 SIGNALING	10	4.95e-01	5.85e-01	0.3260	-0.165000	1.97e-01	-0.201000	3.67e-01	2.81e-01	2.70e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	7.32e-06	7.32e-05	0.3250	-0.312000	-5.66e-02	-0.072500	1.21e-06	3.79e-01	2.59e-01
FLT3 SIGNALING	26	1.76e-02	4.35e-02	0.3250	0.045000	-1.21e-02	-0.321000	6.92e-01	9.15e-01	4.56e-03
N GLYCAN ANTENNAE ELONGATION	13	2.80e-01	3.81e-01	0.3240	-0.173000	6.28e-02	-0.267000	2.80e-01	6.95e-01	9.59e-02
HEME DEGRADATION	10	4.63e-01	5.58e-01	0.3240	-0.122000	-1.75e-01	0.243000	5.03e-01	3.37e-01	1.83e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	4.41e-05	3.31e-04	0.3240	-0.309000	-9.73e-02	0.004180	6.92e-06	1.56e-01	9.52e-01
DNA DAMAGE BYPASS	46	1.94e-03	7.27e-03	0.3230	0.028000	5.72e-02	-0.317000	7.43e-01	5.02e-01	2.00e-04
ACTIVATION OF BH3 ONLY PROTEINS	17	1.88e-01	2.82e-01	0.3220	-0.256000	6.94e-02	-0.183000	6.75e-02	6.20e-01	1.92e-01
REGULATION OF RAS BY GAPS	63	1.12e-04	6.98e-04	0.3210	-0.299000	-8.65e-02	-0.079500	4.05e-05	2.35e-01	2.75e-01
TCR SIGNALING	90	2.04e-06	2.29e-05	0.3210	-0.304000	-6.97e-02	-0.077700	6.46e-07	2.53e-01	2.03e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	17	1.05e-01	1.78e-01	0.3200	0.198000	-5.62e-03	-0.251000	1.57e-01	9.68e-01	7.33e-02
ACTIVATION OF APC C AND APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	72	4.93e-05	3.58e-04	0.3190	-0.310000	-6.88e-02	-0.030900	5.35e-06	3.13e-01	6.51e-01
CDC42 GTPASE CYCLE	90	1.05e-04	6.72e-04	0.3190	-0.121000	1.53e-01	-0.252000	4.84e-02	1.20e-02	3.53e-05
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	56	3.83e-04	1.91e-03	0.3180	-0.295000	-9.96e-02	-0.065100	1.32e-04	1.98e-01	4.00e-01
FORMATION OF WDR5 CONTAINING HISTONE MODIFYING COMPLEXES	36	1.07e-02	2.87e-02	0.3180	0.267000	-1.72e-01	0.006770	5.59e-03	7.41e-02	9.44e-01
EXTENSION OF TELOMERES	43	3.75e-03	1.25e-02	0.3170	0.191000	5.82e-02	-0.246000	2.99e-02	5.09e-01	5.26e-03
RND3 GTPASE CYCLE	36	4.24e-02	8.67e-02	0.3170	-0.050700	1.67e-01	-0.265000	5.99e-01	8.38e-02	5.96e-03
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	12	1.60e-01	2.47e-01	0.3170	0.128000	1.25e-01	0.262000	4.44e-01	4.53e-01	1.17e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	12	3.82e-01	4.79e-01	0.3170	0.102000	1.44e-01	-0.263000	5.40e-01	3.89e-01	1.14e-01
DRUG ADME	63	3.00e-03	1.04e-02	0.3160	-0.007540	-1.92e-01	0.252000	9.18e-01	8.56e-03	5.55e-04
CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	69	8.47e-05	5.56e-04	0.3160	-0.295000	-1.14e-01	-0.004360	2.26e-05	1.03e-01	9.50e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	29	6.43e-03	1.88e-02	0.3150	0.150000	-1.00e-01	-0.259000	1.62e-01	3.51e-01	1.59e-02
CELLULAR RESPONSE TO CHEMICAL STRESS	145	3.17e-08	5.09e-07	0.3130	-0.133000	-2.58e-01	0.117000	5.73e-03	8.17e-08	1.51e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD4	14	2.86e-01	3.88e-01	0.3130	-0.284000	9.50e-02	-0.090700	6.54e-02	5.38e-01	5.57e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	16	6.03e-02	1.14e-01	0.3130	-0.067400	1.52e-01	0.265000	6.41e-01	2.93e-01	6.65e-02
SHC MEDIATED CASCADE FGFR2	12	1.53e-01	2.38e-01	0.3120	-0.141000	-2.02e-01	-0.193000	3.99e-01	2.27e-01	2.47e-01
GLUCAGON TYPE LIGAND RECEPTORS	17	1.84e-01	2.78e-01	0.3120	-0.224000	3.18e-02	-0.215000	1.10e-01	8.21e-01	1.24e-01
DOWNSTREAM TCR SIGNALING	78	2.28e-05	1.93e-04	0.3120	-0.289000	-1.11e-01	-0.036700	1.01e-05	9.03e-02	5.76e-01
KEAP1 NFE2L2 PATHWAY	73	2.91e-05	2.33e-04	0.3120	-0.269000	-1.50e-01	-0.048400	7.30e-05	2.65e-02	4.75e-01
REGULATION OF BACH1 ACTIVITY	10	3.17e-01	4.18e-01	0.3110	0.221000	-2.10e-01	-0.061000	2.25e-01	2.50e-01	7.38e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	40	3.86e-02	8.21e-02	0.3110	-0.003650	-2.07e-01	0.232000	9.68e-01	2.33e-02	1.11e-02
IRAK1 RECRUITS IKK COMPLEX	14	2.43e-01	3.42e-01	0.3110	0.279000	-1.38e-01	-0.001370	7.12e-02	3.71e-01	9.93e-01
SYNTHESIS OF PE	10	4.45e-01	5.42e-01	0.3110	-0.230000	-1.45e-01	0.150000	2.08e-01	4.26e-01	4.12e-01
ACTIVATION OF NF KAPPAB IN B CELLS	59	5.39e-04	2.54e-03	0.3100	-0.300000	-7.75e-02	-0.025200	6.96e-05	3.03e-01	7.38e-01
DAP12 SIGNALING	21	1.86e-01	2.80e-01	0.3100	-0.203000	1.53e-01	-0.177000	1.07e-01	2.25e-01	1.59e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	14	3.27e-01	4.28e-01	0.3090	0.178000	1.89e-01	-0.168000	2.48e-01	2.21e-01	2.78e-01
SIGNAL AMPLIFICATION	26	6.85e-02	1.25e-01	0.3090	-0.285000	3.14e-02	-0.116000	1.20e-02	7.81e-01	3.05e-01
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	4.76e-01	5.68e-01	0.3080	0.143000	-2.55e-01	0.096400	4.33e-01	1.62e-01	5.98e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	60	5.96e-04	2.73e-03	0.3080	-0.302000	-4.45e-02	-0.044600	5.38e-05	5.52e-01	5.51e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	19	2.31e-01	3.28e-01	0.3080	-0.177000	1.31e-01	-0.215000	1.81e-01	3.22e-01	1.05e-01
NICOTINAMIDE SALVAGING	15	3.12e-01	4.14e-01	0.3080	-0.230000	1.18e-01	-0.166000	1.23e-01	4.28e-01	2.65e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	4.04e-02	8.39e-02	0.3080	-0.298000	-6.65e-02	0.038000	5.50e-03	5.36e-01	7.23e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	1.41e-01	2.22e-01	0.3070	-0.219000	-1.58e-01	-0.145000	1.41e-01	2.89e-01	3.33e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	3.92e-02	8.25e-02	0.3060	0.126000	-2.69e-01	-0.074900	3.05e-01	2.93e-02	5.43e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	13	3.40e-01	4.43e-01	0.3050	-0.230000	1.89e-01	-0.067200	1.51e-01	2.37e-01	6.75e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	14	3.80e-01	4.78e-01	0.3050	-0.105000	1.35e-01	-0.252000	4.96e-01	3.82e-01	1.02e-01
MHC CLASS II ANTIGEN PRESENTATION	98	1.94e-05	1.70e-04	0.3040	-0.270000	7.55e-02	-0.117000	4.02e-06	1.97e-01	4.47e-02
SIGNALING BY TGF BETA RECEPTOR COMPLEX	73	2.43e-03	8.71e-03	0.3030	-0.080600	1.90e-01	-0.222000	2.34e-01	5.09e-03	1.06e-03
RHOF GTPASE CYCLE	39	2.76e-02	6.33e-02	0.3010	-0.169000	9.05e-02	-0.232000	6.79e-02	3.28e-01	1.21e-02
HATS ACETYLATE HISTONES	29	1.58e-02	3.99e-02	0.3010	0.022600	-2.97e-01	-0.043700	8.33e-01	5.65e-03	6.84e-01
FOXO MEDIATED TRANSCRIPTION	20	4.20e-02	8.61e-02	0.3000	0.030900	-1.15e-01	-0.275000	8.11e-01	3.73e-01	3.30e-02
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	53	5.69e-03	1.70e-02	0.3000	0.054600	1.13e-01	-0.272000	4.92e-01	1.55e-01	6.05e-04
SHC MEDIATED CASCADE FGFR4	11	2.09e-01	3.08e-01	0.3000	-0.119000	-2.07e-01	-0.182000	4.96e-01	2.36e-01	2.96e-01
CD209 DC SIGN SIGNALING	16	2.09e-01	3.07e-01	0.3000	-0.243000	-1.95e-02	-0.174000	9.20e-02	8.93e-01	2.28e-01
PENTOSE PHOSPHATE PATHWAY	14	3.17e-01	4.18e-01	0.2990	-0.136000	-9.79e-02	0.248000	3.79e-01	5.26e-01	1.08e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	59	9.04e-04	3.85e-03	0.2990	-0.282000	-9.86e-02	-0.017600	1.84e-04	1.90e-01	8.15e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	1.30e-04	7.97e-04	0.2990	-0.218000	1.88e-01	-0.078900	4.67e-04	2.65e-03	2.06e-01
SIGNALING BY ALK	14	3.95e-01	4.92e-01	0.2980	-0.002520	2.63e-01	-0.140000	9.87e-01	8.81e-02	3.64e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	4.60e-01	5.56e-01	0.2980	0.013300	2.41e-01	-0.175000	9.34e-01	1.32e-01	2.76e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	2.29e-01	3.28e-01	0.2980	-0.011900	3.20e-02	-0.296000	9.36e-01	8.30e-01	4.73e-02
FCERI MEDIATED NF KB ACTIVATION	70	2.73e-04	1.44e-03	0.2970	-0.267000	-1.30e-01	0.020400	1.16e-04	6.07e-02	7.69e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	34	4.04e-02	8.39e-02	0.2970	0.049900	9.32e-02	-0.277000	6.15e-01	3.47e-01	5.19e-03
GRB2 EVENTS IN ERBB2 SIGNALING	10	5.71e-01	6.50e-01	0.2960	-0.136000	2.14e-01	-0.153000	4.56e-01	2.42e-01	4.01e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	1.79e-01	2.70e-01	0.2960	-0.090900	-1.73e-01	-0.222000	5.86e-01	3.00e-01	1.83e-01
SIGNALING BY TGFB FAMILY MEMBERS	105	1.79e-04	1.03e-03	0.2960	-0.095900	2.13e-01	-0.181000	8.99e-02	1.65e-04	1.34e-03
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	14	2.53e-01	3.53e-01	0.2950	0.115000	2.81e-02	-0.270000	4.58e-01	8.56e-01	7.98e-02
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	81	6.46e-05	4.30e-04	0.2950	-0.282000	-7.18e-02	-0.048900	1.18e-05	2.65e-01	4.47e-01
INTERLEUKIN 7 SIGNALING	12	2.17e-01	3.17e-01	0.2940	-0.162000	-1.70e-01	-0.177000	3.32e-01	3.09e-01	2.87e-01
MAP2K AND MAPK ACTIVATION	36	3.54e-02	7.74e-02	0.2940	-0.239000	1.59e-01	-0.063900	1.32e-02	9.93e-02	5.07e-01
CHROMOSOME MAINTENANCE	66	1.22e-03	4.86e-03	0.2920	0.109000	9.32e-02	-0.255000	1.27e-01	1.90e-01	3.44e-04
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	23	2.26e-02	5.34e-02	0.2910	0.000680	1.86e-01	0.223000	9.95e-01	1.22e-01	6.37e-02
INTERLEUKIN 1 FAMILY SIGNALING	105	8.66e-06	8.56e-05	0.2900	-0.273000	-6.66e-04	-0.098200	1.32e-06	9.91e-01	8.23e-02
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	4.22e-01	5.21e-01	0.2900	0.248000	-1.46e-01	-0.037300	1.74e-01	4.23e-01	8.38e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	58	4.54e-03	1.44e-02	0.2900	-0.193000	-1.54e-01	0.153000	1.11e-02	4.23e-02	4.43e-02
MISMATCH REPAIR	14	2.14e-01	3.12e-01	0.2900	0.135000	-2.83e-02	-0.255000	3.81e-01	8.55e-01	9.83e-02
GLUCOSE METABOLISM	64	1.71e-03	6.53e-03	0.2900	-0.139000	-2.39e-01	0.085500	5.46e-02	9.31e-04	2.37e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	61	1.05e-03	4.33e-03	0.2890	-0.268000	-1.05e-01	-0.025800	2.99e-04	1.55e-01	7.27e-01
SIGNALING BY VEGF	98	5.06e-05	3.63e-04	0.2890	-0.216000	5.17e-02	-0.185000	2.25e-04	3.77e-01	1.56e-03
ORC1 REMOVAL FROM CHROMATIN	65	5.87e-04	2.71e-03	0.2890	-0.251000	-4.37e-02	-0.135000	4.60e-04	5.42e-01	6.02e-02
ERK MAPK TARGETS	19	1.69e-01	2.58e-01	0.2880	-0.239000	-1.61e-01	0.007850	7.14e-02	2.23e-01	9.53e-01
COSTIMULATION BY THE CD28 FAMILY	52	4.06e-03	1.32e-02	0.2880	-0.277000	-3.74e-02	-0.072600	5.62e-04	6.41e-01	3.65e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	42	2.11e-02	5.04e-02	0.2880	-0.235000	1.56e-01	-0.056700	8.43e-03	8.00e-02	5.25e-01
PCP CE PATHWAY	82	1.15e-04	7.11e-04	0.2870	-0.278000	-6.03e-02	-0.036100	1.34e-05	3.46e-01	5.73e-01
CELL CELL COMMUNICATION	70	4.11e-03	1.33e-02	0.2870	-0.158000	1.86e-01	-0.150000	2.25e-02	7.08e-03	2.98e-02
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	1.08e-01	1.82e-01	0.2870	-0.103000	1.74e-01	-0.203000	3.00e-01	7.84e-02	4.07e-02
PTEN REGULATION	95	1.79e-05	1.60e-04	0.2860	-0.214000	-1.89e-01	0.017300	3.24e-04	1.45e-03	7.71e-01
PI 3K CASCADE FGFR1	12	2.48e-01	3.46e-01	0.2850	-0.147000	-2.14e-01	-0.118000	3.78e-01	2.00e-01	4.81e-01
RHOB GTPASE CYCLE	65	9.85e-03	2.68e-02	0.2840	-0.044400	1.71e-01	-0.222000	5.36e-01	1.69e-02	1.96e-03
METABOLISM OF VITAMINS AND COFACTORS	157	1.05e-06	1.27e-05	0.2840	-0.125000	-1.81e-01	0.180000	7.13e-03	9.56e-05	9.88e-05
EUKARYOTIC TRANSLATION INITIATION	112	3.30e-05	2.58e-04	0.2840	-0.152000	-1.35e-01	0.198000	5.48e-03	1.38e-02	2.98e-04
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	15	3.80e-01	4.78e-01	0.2840	0.134000	1.42e-01	-0.206000	3.70e-01	3.41e-01	1.67e-01
SMOOTH MUSCLE CONTRACTION	29	2.60e-02	5.99e-02	0.2840	-0.208000	1.13e-01	0.156000	5.24e-02	2.93e-01	1.46e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	11	2.92e-01	3.93e-01	0.2830	0.152000	2.08e-01	0.118000	3.84e-01	2.32e-01	4.96e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	10	6.33e-01	7.00e-01	0.2830	0.026000	-1.88e-01	0.210000	8.87e-01	3.02e-01	2.51e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	16	4.11e-01	5.11e-01	0.2830	-0.002120	1.59e-01	-0.233000	9.88e-01	2.70e-01	1.06e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	110	2.93e-05	2.33e-04	0.2820	-0.218000	1.65e-01	-0.069500	8.09e-05	2.80e-03	2.08e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	214	1.61e-09	2.90e-08	0.2820	-0.230000	1.29e-01	-0.100000	7.47e-09	1.15e-03	1.18e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	5.15e-01	6.05e-01	0.2820	-0.271000	3.26e-02	-0.071700	1.39e-01	8.58e-01	6.95e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	4.22e-01	5.21e-01	0.2820	-0.215000	1.69e-01	-0.069200	1.80e-01	2.92e-01	6.66e-01
G ALPHA Z SIGNALLING EVENTS	27	9.40e-02	1.62e-01	0.2820	-0.269000	-6.78e-03	-0.082700	1.56e-02	9.51e-01	4.57e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	60	4.50e-03	1.43e-02	0.2810	-0.214000	5.14e-02	-0.175000	4.16e-03	4.92e-01	1.90e-02
CLASS B 2 SECRETIN FAMILY RECEPTORS	28	9.52e-02	1.64e-01	0.2810	-0.123000	5.11e-02	-0.248000	2.61e-01	6.40e-01	2.33e-02
BIOLOGICAL OXIDATIONS	130	1.87e-05	1.65e-04	0.2810	-0.073900	-1.47e-01	0.228000	1.46e-01	3.78e-03	7.44e-06
HDMS DEMETHYLATE HISTONES	21	5.95e-02	1.13e-01	0.2800	0.127000	-1.29e-01	-0.214000	3.14e-01	3.07e-01	8.99e-02
GOLGI TO ER RETROGRADE TRANSPORT	116	2.72e-05	2.27e-04	0.2800	-0.211000	1.63e-01	-0.083200	8.65e-05	2.43e-03	1.22e-01
SIGNALING BY SCF KIT	33	3.72e-02	8.03e-02	0.2790	-0.219000	-3.63e-02	-0.169000	2.92e-02	7.18e-01	9.33e-02
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	49	3.60e-02	7.85e-02	0.2780	-0.143000	1.56e-01	-0.180000	8.25e-02	5.92e-02	2.95e-02
L1CAM INTERACTIONS	63	7.41e-03	2.13e-02	0.2780	-0.189000	1.68e-01	-0.114000	9.45e-03	2.12e-02	1.16e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	12	4.43e-01	5.41e-01	0.2770	-0.003350	-2.69e-01	0.065400	9.84e-01	1.06e-01	6.95e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	10	6.49e-01	7.15e-01	0.2770	0.026600	-2.06e-01	0.183000	8.84e-01	2.59e-01	3.17e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	66	9.85e-04	4.10e-03	0.2770	-0.237000	-1.43e-01	-0.010900	8.91e-04	4.52e-02	8.78e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	14	3.54e-01	4.55e-01	0.2760	-0.160000	-2.20e-01	0.050300	2.99e-01	1.55e-01	7.45e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	103	2.19e-06	2.43e-05	0.2760	0.192000	-4.04e-02	-0.194000	7.60e-04	4.79e-01	6.81e-04
ERKS ARE INACTIVATED	13	3.17e-01	4.18e-01	0.2760	-0.218000	-9.04e-02	-0.142000	1.74e-01	5.73e-01	3.75e-01
CD28 CO STIMULATION	31	1.19e-01	1.96e-01	0.2750	-0.200000	1.08e-01	-0.155000	5.38e-02	2.97e-01	1.36e-01
TRANSLESION SYNTHESIS BY POLH	18	1.20e-01	1.97e-01	0.2750	-0.050000	-8.34e-02	-0.257000	7.14e-01	5.40e-01	5.87e-02
FORMATION OF THE CORNIFIED ENVELOPE	17	3.57e-01	4.57e-01	0.2740	-0.213000	1.24e-01	-0.121000	1.29e-01	3.75e-01	3.89e-01
KERATINIZATION	17	3.57e-01	4.57e-01	0.2740	-0.213000	1.24e-01	-0.121000	1.29e-01	3.75e-01	3.89e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	24	1.08e-01	1.82e-01	0.2740	-0.230000	-6.31e-02	-0.134000	5.09e-02	5.93e-01	2.55e-01
METHYLATION	13	4.51e-01	5.48e-01	0.2740	-0.161000	-1.94e-01	0.106000	3.14e-01	2.26e-01	5.07e-01
G2 M DNA DAMAGE CHECKPOINT	52	1.80e-02	4.43e-02	0.2720	-0.009040	9.69e-02	-0.254000	9.10e-01	2.27e-01	1.52e-03
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	86	1.39e-03	5.44e-03	0.2720	-0.178000	1.06e-01	-0.177000	4.44e-03	8.99e-02	4.64e-03
SIGNALING BY INTERLEUKINS	222	3.93e-10	7.86e-09	0.2720	-0.242000	2.31e-02	-0.121000	5.14e-10	5.54e-01	1.94e-03
CHEMOKINE RECEPTORS BIND CHEMOKINES	20	2.60e-01	3.61e-01	0.2720	-0.236000	6.28e-02	-0.118000	6.72e-02	6.27e-01	3.62e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	68	6.60e-04	3.00e-03	0.2710	-0.234000	-1.01e-01	-0.092100	8.38e-04	1.50e-01	1.89e-01
GAP JUNCTION DEGRADATION	11	6.02e-01	6.75e-01	0.2710	-0.119000	2.02e-01	-0.136000	4.94e-01	2.47e-01	4.33e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	22	1.37e-01	2.20e-01	0.2690	0.152000	7.75e-03	-0.222000	2.16e-01	9.50e-01	7.17e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	25	1.21e-01	1.98e-01	0.2690	-0.135000	-3.95e-02	0.230000	2.44e-01	7.33e-01	4.67e-02
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	56	1.31e-02	3.44e-02	0.2680	0.026800	9.31e-02	-0.250000	7.29e-01	2.29e-01	1.21e-03
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	104	6.77e-04	3.06e-03	0.2680	-0.073600	-1.75e-01	0.189000	1.95e-01	2.04e-03	8.88e-04
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	19	3.93e-01	4.90e-01	0.2680	-0.075800	1.53e-01	-0.206000	5.67e-01	2.47e-01	1.20e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	20	3.15e-01	4.17e-01	0.2670	-0.183000	9.92e-02	-0.167000	1.57e-01	4.42e-01	1.95e-01
ENDOGENOUS STEROLS	17	3.89e-01	4.86e-01	0.2670	-0.126000	-1.50e-01	0.181000	3.69e-01	2.85e-01	1.95e-01
AURKA ACTIVATION BY TPX2	68	7.92e-03	2.23e-02	0.2670	-0.119000	1.01e-01	-0.216000	8.93e-02	1.50e-01	2.08e-03
FORMATION OF INCISION COMPLEX IN GG NER	43	1.13e-02	3.01e-02	0.2670	0.093000	-2.49e-01	-0.017500	2.91e-01	4.71e-03	8.42e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	2.40e-01	3.39e-01	0.2660	-0.240000	3.50e-02	-0.109000	5.67e-02	7.81e-01	3.89e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	34	1.61e-01	2.48e-01	0.2660	-0.012700	1.78e-01	-0.196000	8.98e-01	7.18e-02	4.77e-02
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	2.26e-04	1.24e-03	0.2650	-0.242000	-5.53e-02	-0.093500	1.07e-04	3.76e-01	1.34e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	37	3.61e-02	7.85e-02	0.2650	0.154000	2.74e-02	-0.214000	1.04e-01	7.73e-01	2.46e-02
METABOLISM OF LIPIDS	463	2.46e-16	1.01e-14	0.2650	-0.064300	-1.39e-01	0.216000	1.83e-02	3.52e-07	2.08e-15
RHOC GTPASE CYCLE	65	1.35e-02	3.50e-02	0.2650	-0.089400	1.18e-01	-0.219000	2.13e-01	9.98e-02	2.24e-03
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	21	2.64e-01	3.64e-01	0.2650	-0.061300	-2.42e-01	0.089100	6.27e-01	5.54e-02	4.80e-01
PROTEIN HYDROXYLATION	16	4.88e-01	5.79e-01	0.2640	0.053700	-1.58e-01	0.205000	7.10e-01	2.73e-01	1.56e-01
RHO GTPASES ACTIVATE FORMINS	116	3.26e-04	1.66e-03	0.2640	-0.156000	1.51e-01	-0.151000	3.81e-03	5.04e-03	5.04e-03
ENOS ACTIVATION	12	3.46e-01	4.46e-01	0.2640	-0.012100	-4.10e-02	-0.260000	9.42e-01	8.06e-01	1.19e-01
INTERLEUKIN 1 SIGNALING	96	1.51e-04	8.88e-04	0.2630	-0.253000	-2.60e-02	-0.069100	1.87e-05	6.61e-01	2.43e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	15	2.69e-01	3.69e-01	0.2630	-0.109000	2.37e-01	0.035900	4.64e-01	1.12e-01	8.10e-01
EPH EPHRIN SIGNALING	57	2.92e-02	6.61e-02	0.2630	-0.144000	1.38e-01	-0.171000	6.05e-02	7.16e-02	2.55e-02
COPI MEDIATED ANTEROGRADE TRANSPORT	89	7.11e-04	3.17e-03	0.2620	-0.238000	4.88e-02	-0.099100	1.05e-04	4.26e-01	1.07e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	14	3.89e-01	4.86e-01	0.2620	0.251000	6.25e-02	0.044000	1.04e-01	6.86e-01	7.76e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	73	1.00e-03	4.15e-03	0.2610	-0.236000	-1.03e-01	-0.042900	4.87e-04	1.28e-01	5.26e-01
HEDGEHOG ON STATE	75	2.56e-03	9.03e-03	0.2610	-0.240000	4.63e-02	-0.091600	3.27e-04	4.88e-01	1.71e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	13	4.48e-01	5.45e-01	0.2600	0.249000	-7.39e-02	0.001080	1.20e-01	6.44e-01	9.95e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	29	4.05e-02	8.39e-02	0.2590	-0.134000	-1.21e-01	-0.187000	2.13e-01	2.60e-01	8.20e-02
RESOLUTION OF SISTER CHROMATID COHESION	102	1.12e-03	4.52e-03	0.2590	-0.118000	1.15e-01	-0.200000	4.03e-02	4.44e-02	4.90e-04
C TYPE LECTIN RECEPTORS CLRS	104	5.58e-05	3.89e-04	0.2590	-0.240000	-8.29e-02	-0.048800	2.35e-05	1.44e-01	3.90e-01
CLEC7A DECTIN 1 SIGNALING	88	3.14e-04	1.64e-03	0.2590	-0.242000	-8.01e-02	-0.041500	8.57e-05	1.94e-01	5.02e-01
G2 M CHECKPOINTS	121	4.73e-05	3.52e-04	0.2590	-0.146000	4.70e-02	-0.208000	5.74e-03	3.73e-01	7.61e-05
LYSOSOME VESICLE BIOGENESIS	30	5.22e-02	1.02e-01	0.2580	-0.200000	1.09e-01	0.121000	5.83e-02	3.00e-01	2.50e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	25	1.14e-01	1.89e-01	0.2580	-0.076700	-1.57e-02	-0.246000	5.07e-01	8.92e-01	3.34e-02
NONSENSE MEDIATED DECAY NMD	107	4.86e-04	2.35e-03	0.2580	-0.091100	-1.24e-01	0.207000	1.04e-01	2.71e-02	2.18e-04
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	42	4.38e-02	8.90e-02	0.2560	-0.062300	4.76e-02	-0.244000	4.85e-01	5.94e-01	6.30e-03
RHOD GTPASE CYCLE	49	4.19e-02	8.61e-02	0.2560	-0.047100	9.09e-02	-0.234000	5.68e-01	2.71e-01	4.57e-03
BETA CATENIN INDEPENDENT WNT SIGNALING	112	2.93e-05	2.33e-04	0.2550	-0.233000	-9.17e-02	-0.049100	2.08e-05	9.41e-02	3.70e-01
INWARDLY RECTIFYING K CHANNELS	25	2.26e-01	3.25e-01	0.2540	-0.172000	-1.43e-01	0.122000	1.37e-01	2.16e-01	2.92e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	99	1.79e-03	6.81e-03	0.2540	-0.161000	1.46e-01	-0.132000	5.66e-03	1.23e-02	2.39e-02
SYNTHESIS OF PC	21	3.77e-01	4.76e-01	0.2540	-0.028200	-2.08e-01	0.142000	8.23e-01	9.83e-02	2.59e-01
INTRA GOLGI TRAFFIC	33	7.19e-02	1.31e-01	0.2540	-0.230000	-7.45e-02	-0.077800	2.23e-02	4.59e-01	4.40e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	79	1.11e-02	2.97e-02	0.2540	0.023200	1.73e-01	-0.184000	7.22e-01	7.83e-03	4.71e-03
HOMOLOGY DIRECTED REPAIR	93	5.38e-04	2.54e-03	0.2540	0.047100	6.17e-02	-0.242000	4.33e-01	3.05e-01	5.75e-05
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	4.86e-02	9.64e-02	0.2540	-0.036900	-2.37e-01	-0.081600	7.36e-01	2.98e-02	4.55e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	28	7.65e-02	1.37e-01	0.2530	-0.071700	-3.76e-02	-0.240000	5.11e-01	7.30e-01	2.80e-02
MITOTIC G1 PHASE AND G1 S TRANSITION	126	2.31e-05	1.94e-04	0.2520	-0.146000	2.14e-02	-0.205000	4.82e-03	6.78e-01	7.11e-05
PROCESSING AND ACTIVATION OF SUMO	10	6.58e-01	7.22e-01	0.2520	-0.124000	2.00e-01	-0.092400	4.98e-01	2.75e-01	6.13e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	75	2.02e-03	7.55e-03	0.2520	-0.211000	-1.37e-01	0.021100	1.59e-03	4.11e-02	7.52e-01
G1 S DNA DAMAGE CHECKPOINTS	61	4.78e-03	1.49e-02	0.2510	-0.221000	-1.02e-01	-0.062300	2.91e-03	1.68e-01	4.00e-01
EPHRIN SIGNALING	18	2.88e-01	3.89e-01	0.2500	-0.179000	-2.79e-02	-0.173000	1.89e-01	8.38e-01	2.05e-01
RHO GTPASES ACTIVATE PKNS	21	2.60e-01	3.61e-01	0.2490	-0.232000	8.95e-02	0.006620	6.53e-02	4.78e-01	9.58e-01
ION HOMEOSTASIS	45	9.69e-02	1.66e-01	0.2490	-0.018000	-1.42e-01	0.204000	8.35e-01	9.86e-02	1.82e-02
APOPTOSIS	89	1.68e-03	6.47e-03	0.2490	-0.171000	4.75e-02	-0.175000	5.45e-03	4.39e-01	4.34e-03
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	28	1.41e-01	2.22e-01	0.2490	-0.158000	-1.90e-01	0.027000	1.48e-01	8.22e-02	8.05e-01
MAPK6 MAPK4 SIGNALING	70	4.46e-03	1.42e-02	0.2480	-0.244000	-3.02e-02	-0.032900	4.11e-04	6.63e-01	6.35e-01
OPIOID SIGNALLING	59	1.01e-02	2.75e-02	0.2480	-0.223000	-2.49e-02	-0.107000	3.10e-03	7.41e-01	1.57e-01
RHOA GTPASE CYCLE	132	3.25e-04	1.66e-03	0.2480	-0.108000	1.18e-01	-0.190000	3.25e-02	1.97e-02	1.70e-04
SIGNALING BY HEDGEHOG	125	1.46e-04	8.74e-04	0.2480	-0.213000	9.39e-02	-0.083400	3.85e-05	7.02e-02	1.08e-01
SIGNALING BY THE B CELL RECEPTOR BCR	94	3.27e-04	1.66e-03	0.2470	-0.226000	-6.22e-02	-0.079800	1.57e-04	2.98e-01	1.82e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	12	5.76e-01	6.54e-01	0.2470	-0.076900	2.23e-01	-0.072100	6.45e-01	1.80e-01	6.66e-01
HEMOSTASIS	424	6.71e-14	2.08e-12	0.2470	-0.192000	1.23e-01	-0.094100	1.46e-11	1.49e-05	9.40e-04
DOWNSTREAM SIGNAL TRANSDUCTION	26	2.03e-01	3.01e-01	0.2460	-0.240000	1.69e-02	-0.050100	3.38e-02	8.82e-01	6.58e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	360	1.09e-12	3.08e-11	0.2460	-0.193000	4.56e-02	-0.146000	3.98e-10	1.39e-01	2.02e-06
NUCLEOTIDE SALVAGE	19	3.22e-01	4.23e-01	0.2460	0.194000	1.46e-01	-0.038700	1.43e-01	2.71e-01	7.70e-01
RA BIOSYNTHESIS PATHWAY	15	4.71e-01	5.65e-01	0.2460	-0.148000	-9.00e-02	0.174000	3.20e-01	5.46e-01	2.44e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	39	1.08e-01	1.82e-01	0.2460	-0.122000	7.55e-02	-0.199000	1.87e-01	4.15e-01	3.14e-02
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	28	2.28e-01	3.28e-01	0.2450	-0.122000	-1.21e-01	0.175000	2.66e-01	2.67e-01	1.08e-01
PLASMA LIPOPROTEIN REMODELING	19	4.09e-01	5.08e-01	0.2450	-0.099500	-1.18e-01	0.190000	4.53e-01	3.74e-01	1.51e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	15	4.68e-01	5.62e-01	0.2440	-0.139000	-1.88e-01	0.071900	3.50e-01	2.08e-01	6.30e-01
S PHASE	140	4.09e-06	4.24e-05	0.2440	-0.114000	-3.40e-03	-0.216000	2.03e-02	9.45e-01	1.01e-05
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	28	9.95e-02	1.71e-01	0.2440	-0.162000	1.74e-01	0.055500	1.39e-01	1.12e-01	6.11e-01
RHO GTPASE CYCLE	390	1.59e-11	3.88e-10	0.2440	-0.125000	1.08e-01	-0.179000	2.46e-05	2.52e-04	1.56e-09
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	564	7.12e-17	3.56e-15	0.2430	-0.158000	1.01e-01	-0.155000	1.98e-10	4.32e-05	3.65e-10
RHOBTB1 GTPASE CYCLE	22	2.76e-01	3.77e-01	0.2430	0.221000	6.80e-02	-0.074300	7.24e-02	5.81e-01	5.46e-01
SIGNALING BY FGFR3	32	2.52e-02	5.84e-02	0.2430	0.028800	-1.68e-01	-0.174000	7.78e-01	1.01e-01	8.91e-02
TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION	36	9.58e-02	1.65e-01	0.2430	-0.164000	1.80e-02	-0.178000	8.87e-02	8.52e-01	6.42e-02
O LINKED GLYCOSYLATION	72	7.24e-03	2.09e-02	0.2430	-0.052300	2.30e-01	-0.059200	4.43e-01	7.58e-04	3.85e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	12	5.49e-01	6.33e-01	0.2430	0.006430	2.37e-01	-0.050100	9.69e-01	1.54e-01	7.64e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	21	4.34e-01	5.33e-01	0.2430	-0.077600	1.84e-01	-0.138000	5.38e-01	1.45e-01	2.73e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	169	8.95e-06	8.76e-05	0.2420	-0.208000	8.96e-02	-0.086100	3.18e-06	4.47e-02	5.40e-02
SIGNAL TRANSDUCTION BY L1	19	4.96e-01	5.85e-01	0.2420	-0.048800	1.57e-01	-0.178000	7.13e-01	2.35e-01	1.80e-01
UCH PROTEINASES	77	4.32e-03	1.39e-02	0.2420	-0.208000	-1.05e-01	0.063000	1.58e-03	1.12e-01	3.40e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	1.74e-02	4.33e-02	0.2410	-0.033500	-2.30e-01	-0.065000	7.11e-01	1.09e-02	4.71e-01
FRS MEDIATED FGFR1 SIGNALING	13	3.76e-01	4.75e-01	0.2410	-0.058300	-2.27e-01	-0.054400	7.16e-01	1.56e-01	7.34e-01
INTERLEUKIN 20 FAMILY SIGNALING	11	5.90e-01	6.65e-01	0.2410	-0.228000	-5.87e-02	0.050100	1.90e-01	7.36e-01	7.74e-01
INNATE IMMUNE SYSTEM	712	2.61e-23	2.35e-21	0.2410	-0.216000	5.83e-02	-0.088800	1.65e-22	8.49e-03	6.13e-05
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	30	2.47e-01	3.46e-01	0.2410	-0.144000	1.06e-01	-0.161000	1.73e-01	3.16e-01	1.26e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	359	7.63e-11	1.68e-09	0.2400	-0.176000	1.09e-01	-0.122000	1.12e-08	4.22e-04	7.56e-05
POTASSIUM CHANNELS	56	5.91e-02	1.13e-01	0.2390	-0.077100	-1.61e-01	0.159000	3.19e-01	3.77e-02	3.93e-02
PLASMA LIPOPROTEIN CLEARANCE	28	1.75e-01	2.65e-01	0.2390	-0.205000	-1.21e-01	0.017400	6.04e-02	2.67e-01	8.73e-01
HEDGEHOG OFF STATE	100	8.66e-04	3.76e-03	0.2390	-0.234000	3.62e-02	-0.028000	5.30e-05	5.32e-01	6.29e-01
HDACS DEACETYLATE HISTONES	29	1.40e-01	2.22e-01	0.2380	-0.115000	-2.46e-03	-0.209000	2.86e-01	9.82e-01	5.13e-02
APOPTOTIC EXECUTION PHASE	42	1.11e-01	1.86e-01	0.2380	-0.102000	8.26e-02	-0.199000	2.55e-01	3.55e-01	2.56e-02
REGULATED NECROSIS	45	8.52e-02	1.50e-01	0.2380	-0.139000	6.95e-02	-0.180000	1.06e-01	4.20e-01	3.65e-02
PLATELET HOMEOSTASIS	64	1.35e-02	3.50e-02	0.2380	-0.233000	5.09e-03	-0.048300	1.26e-03	9.44e-01	5.04e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK IKBKE	17	4.42e-01	5.41e-01	0.2380	-0.199000	1.21e-01	-0.047100	1.55e-01	3.87e-01	7.37e-01
CELL CYCLE	508	3.82e-16	1.49e-14	0.2370	-0.094800	6.32e-02	-0.208000	2.76e-04	1.52e-02	1.20e-15
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	92	6.73e-03	1.96e-02	0.2370	-0.064200	1.06e-01	-0.202000	2.88e-01	7.99e-02	8.03e-04
NRAGE SIGNALS DEATH THROUGH JNK	49	1.08e-01	1.82e-01	0.2370	0.019100	1.51e-01	-0.182000	8.17e-01	6.76e-02	2.78e-02
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	2.31e-01	3.28e-01	0.2360	0.135000	3.30e-02	-0.191000	2.53e-01	7.80e-01	1.05e-01
SIGNALING BY NTRK1 TRKA	62	1.66e-02	4.17e-02	0.2360	-0.233000	-1.70e-03	-0.034200	1.49e-03	9.81e-01	6.42e-01
PROGRAMMED CELL DEATH	117	6.41e-04	2.93e-03	0.2360	-0.169000	5.75e-02	-0.154000	1.65e-03	2.83e-01	3.99e-03
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	72	1.07e-03	4.36e-03	0.2360	0.094700	-4.46e-02	-0.211000	1.65e-01	5.13e-01	1.96e-03
MITOTIC PROMETAPHASE	171	4.87e-05	3.56e-04	0.2360	-0.079500	9.83e-02	-0.199000	7.33e-02	2.68e-02	7.58e-06
RHOQ GTPASE CYCLE	56	4.48e-02	9.05e-02	0.2350	-0.090600	7.29e-02	-0.205000	2.41e-01	3.45e-01	8.14e-03
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	3.59e-01	4.58e-01	0.2350	0.107000	8.02e-02	-0.193000	3.97e-01	5.24e-01	1.26e-01
CARDIAC CONDUCTION	76	2.15e-02	5.11e-02	0.2350	-0.004820	-1.21e-01	0.201000	9.42e-01	6.73e-02	2.52e-03
DNA REPLICATION PRE INITIATION	97	8.50e-04	3.73e-03	0.2340	-0.208000	-2.41e-02	-0.105000	4.00e-04	6.82e-01	7.46e-02
IMMUNE SYSTEM	1247	2.73e-37	4.10e-35	0.2340	-0.204000	4.83e-02	-0.103000	3.05e-33	4.63e-03	1.72e-09
PKMTS METHYLATE HISTONE LYSINES	36	6.38e-02	1.18e-01	0.2330	0.132000	-1.90e-02	-0.192000	1.70e-01	8.44e-01	4.68e-02
MACROAUTOPHAGY	119	8.85e-04	3.81e-03	0.2330	-0.128000	-1.24e-01	0.151000	1.63e-02	1.92e-02	4.58e-03
PI METABOLISM	72	2.50e-02	5.79e-02	0.2330	-0.123000	9.77e-02	-0.172000	7.12e-02	1.52e-01	1.15e-02
RMTS METHYLATE HISTONE ARGININES	25	2.21e-01	3.19e-01	0.2330	-0.211000	-9.52e-02	-0.027800	6.78e-02	4.10e-01	8.10e-01
SIGNALING BY NOTCH3	19	3.45e-01	4.46e-01	0.2330	-0.052600	-2.25e-01	0.027800	6.92e-01	8.95e-02	8.34e-01
FATTY ACYL COA BIOSYNTHESIS	26	2.65e-01	3.65e-01	0.2330	0.013300	-6.16e-02	0.224000	9.06e-01	5.87e-01	4.82e-02
TRANSCRIPTIONAL REGULATION BY RUNX3	76	6.26e-03	1.85e-02	0.2320	-0.202000	-2.50e-03	-0.115000	2.33e-03	9.70e-01	8.44e-02
INTERACTION BETWEEN L1 AND ANKYRINS	10	6.58e-01	7.22e-01	0.2320	-0.222000	6.62e-02	-0.012200	2.23e-01	7.17e-01	9.47e-01
RIPK1 MEDIATED REGULATED NECROSIS	29	1.31e-01	2.13e-01	0.2320	-0.055100	-1.27e-02	-0.225000	6.08e-01	9.06e-01	3.59e-02
VISUAL PHOTOTRANSDUCTION	51	3.42e-02	7.58e-02	0.2320	-0.199000	1.19e-01	0.007160	1.41e-02	1.41e-01	9.30e-01
NEUTROPHIL DEGRANULATION	386	2.34e-12	6.37e-11	0.2320	-0.218000	5.79e-02	-0.053800	2.30e-13	5.17e-02	7.06e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	21	3.68e-01	4.67e-01	0.2320	-0.216000	5.16e-02	-0.065100	8.61e-02	6.82e-01	6.06e-01
TIE2 SIGNALING	16	5.77e-01	6.54e-01	0.2310	-0.039500	-1.88e-01	0.129000	7.85e-01	1.93e-01	3.72e-01
OTHER SEMAPHORIN INTERACTIONS	14	5.21e-01	6.10e-01	0.2310	-0.222000	-4.52e-02	0.045900	1.51e-01	7.70e-01	7.66e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	36	1.47e-01	2.30e-01	0.2310	-0.215000	6.37e-02	-0.056000	2.58e-02	5.08e-01	5.61e-01
G1 S TRANSITION	101	7.53e-04	3.32e-03	0.2300	-0.139000	3.97e-03	-0.184000	1.61e-02	9.45e-01	1.43e-03
METABOLISM OF FOLATE AND PTERINES	17	3.72e-01	4.72e-01	0.2290	0.184000	-1.29e-01	-0.044800	1.89e-01	3.59e-01	7.49e-01
NERVOUS SYSTEM DEVELOPMENT	235	1.77e-06	2.07e-05	0.2280	-0.150000	1.41e-01	-0.099900	8.02e-05	2.10e-04	8.48e-03
CELL CYCLE CHECKPOINTS	226	8.56e-07	1.06e-05	0.2280	-0.118000	6.03e-02	-0.186000	2.38e-03	1.19e-01	1.47e-06
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	51	4.74e-02	9.48e-02	0.2280	-0.176000	-1.38e-01	0.044000	2.95e-02	8.76e-02	5.87e-01
SELECTIVE AUTOPHAGY	63	3.17e-02	7.10e-02	0.2280	-0.142000	-1.02e-01	0.147000	5.08e-02	1.64e-01	4.40e-02
NETRIN 1 SIGNALING	12	7.12e-01	7.68e-01	0.2280	-0.044900	1.32e-01	-0.181000	7.88e-01	4.29e-01	2.78e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	20	4.19e-01	5.19e-01	0.2270	-0.114000	5.25e-02	-0.190000	3.78e-01	6.84e-01	1.42e-01
INTERLEUKIN 2 FAMILY SIGNALING	26	2.75e-01	3.76e-01	0.2270	-0.220000	4.65e-02	-0.032900	5.25e-02	6.81e-01	7.71e-01
SHC MEDIATED CASCADE FGFR1	11	5.41e-01	6.27e-01	0.2270	-0.151000	-7.63e-02	-0.150000	3.85e-01	6.61e-01	3.88e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	3.20e-01	4.21e-01	0.2260	-0.000451	-2.21e-01	0.047300	9.97e-01	6.64e-02	6.95e-01
FANCONI ANEMIA PATHWAY	33	1.32e-01	2.13e-01	0.2260	0.207000	-3.37e-02	-0.084100	4.00e-02	7.38e-01	4.03e-01
MUSCLE CONTRACTION	126	3.65e-05	2.81e-04	0.2260	-0.060800	4.09e-03	0.217000	2.39e-01	9.37e-01	2.61e-05
VEGFR2 MEDIATED CELL PROLIFERATION	12	6.17e-01	6.85e-01	0.2250	-0.185000	1.43e-02	-0.127000	2.66e-01	9.32e-01	4.45e-01
RHOG GTPASE CYCLE	67	2.35e-02	5.52e-02	0.2250	-0.109000	4.54e-02	-0.192000	1.25e-01	5.21e-01	6.72e-03
SIGNALING BY FGFR4	32	4.76e-02	9.50e-02	0.2240	0.021800	-1.68e-01	-0.147000	8.31e-01	1.01e-01	1.49e-01
UB SPECIFIC PROCESSING PROTEASES	151	4.02e-05	3.04e-04	0.2240	-0.217000	-3.16e-02	-0.042800	4.14e-06	5.03e-01	3.64e-01
REGULATION OF SIGNALING BY CBL	21	4.78e-01	5.70e-01	0.2230	-0.136000	1.42e-01	-0.105000	2.82e-01	2.60e-01	4.03e-01
PLATELET CALCIUM HOMEOSTASIS	22	3.44e-01	4.46e-01	0.2230	-0.075600	2.96e-02	-0.208000	5.39e-01	8.10e-01	9.21e-02
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	30	1.47e-01	2.30e-01	0.2220	0.129000	-1.17e-02	-0.180000	2.23e-01	9.12e-01	8.77e-02
CELL JUNCTION ORGANIZATION	59	7.90e-02	1.40e-01	0.2210	-0.116000	1.57e-01	-0.105000	1.23e-01	3.77e-02	1.63e-01
SIGNALING BY PTK6	44	1.86e-01	2.80e-01	0.2210	-0.096000	1.21e-01	-0.158000	2.71e-01	1.64e-01	6.94e-02
PROLONGED ERK ACTIVATION EVENTS	13	5.83e-01	6.58e-01	0.2200	-0.132000	8.87e-03	-0.175000	4.09e-01	9.56e-01	2.75e-01
REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE	32	2.26e-01	3.25e-01	0.2190	-0.160000	3.09e-02	-0.146000	1.17e-01	7.63e-01	1.52e-01
VLDLR INTERNALISATION AND DEGRADATION	15	5.26e-01	6.15e-01	0.2190	-0.129000	-1.74e-01	0.033300	3.88e-01	2.43e-01	8.24e-01
ADAPTIVE IMMUNE SYSTEM	566	5.70e-17	3.02e-15	0.2190	-0.206000	-8.41e-03	-0.072700	7.14e-17	7.34e-01	3.30e-03
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	26	2.93e-01	3.93e-01	0.2190	0.213000	1.09e-02	0.046500	5.99e-02	9.23e-01	6.82e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	7.17e-01	7.71e-01	0.2180	-0.109000	1.74e-01	-0.073200	5.31e-01	3.17e-01	6.74e-01
SIGNALING BY CSF3 G CSF	19	4.25e-01	5.23e-01	0.2180	-0.205000	-7.55e-02	0.004520	1.23e-01	5.69e-01	9.73e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	83	2.77e-02	6.33e-02	0.2180	-0.098800	1.02e-01	-0.165000	1.20e-01	1.07e-01	9.30e-03
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	18	4.42e-01	5.41e-01	0.2180	-0.193000	-1.02e-01	0.003460	1.57e-01	4.53e-01	9.80e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	81	7.53e-03	2.14e-02	0.2170	-0.203000	-7.56e-02	-0.012600	1.59e-03	2.40e-01	8.45e-01
DNA REPLICATION	121	4.20e-04	2.08e-03	0.2170	-0.145000	-4.12e-03	-0.161000	5.84e-03	9.38e-01	2.21e-03
CTLA4 INHIBITORY SIGNALING	20	4.62e-01	5.57e-01	0.2160	-0.152000	-9.29e-02	0.123000	2.40e-01	4.72e-01	3.42e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	20	4.21e-01	5.21e-01	0.2160	-0.212000	-2.85e-02	0.023800	1.00e-01	8.25e-01	8.54e-01
MITOTIC G2 G2 M PHASES	171	1.60e-04	9.20e-04	0.2150	-0.159000	6.75e-02	-0.128000	3.51e-04	1.29e-01	3.85e-03
AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES	79	3.53e-02	7.74e-02	0.2150	-0.092000	9.42e-02	-0.170000	1.58e-01	1.48e-01	9.11e-03
SIGNALING BY ACTIVIN	14	5.68e-01	6.49e-01	0.2140	-0.183000	-2.12e-02	0.109000	2.36e-01	8.91e-01	4.81e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	12	5.44e-01	6.29e-01	0.2140	-0.105000	1.81e-01	0.044500	5.29e-01	2.79e-01	7.90e-01
COPII MEDIATED VESICLE TRANSPORT	66	3.76e-02	8.05e-02	0.2140	-0.161000	-1.18e-01	0.075700	2.38e-02	9.70e-02	2.88e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	12	5.81e-01	6.57e-01	0.2130	-0.128000	1.69e-01	0.024900	4.43e-01	3.11e-01	8.81e-01
RND1 GTPASE CYCLE	38	2.19e-01	3.18e-01	0.2130	0.047000	8.89e-02	-0.188000	6.16e-01	3.43e-01	4.52e-02
NEUROTRANSMITTER RELEASE CYCLE	30	1.18e-01	1.94e-01	0.2130	-0.037600	2.00e-01	0.064200	7.22e-01	5.85e-02	5.43e-01
REGULATION OF TBK1 IKK IKBKE MEDIATED ACTIVATION OF IRF3 IRF7	14	6.61e-01	7.24e-01	0.2130	-0.152000	1.23e-01	-0.083400	3.25e-01	4.24e-01	5.89e-01
SENSORY PERCEPTION	56	4.10e-02	8.48e-02	0.2130	-0.175000	1.21e-01	0.014300	2.39e-02	1.18e-01	8.54e-01
PROTEIN METHYLATION	17	5.60e-01	6.43e-01	0.2110	-0.050400	-7.20e-02	0.191000	7.19e-01	6.08e-01	1.72e-01
TNFR1 INDUCED NF KAPPA B SIGNALING PATHWAY	32	2.63e-01	3.63e-01	0.2100	-0.074300	4.64e-02	-0.191000	4.67e-01	6.50e-01	6.12e-02
RAS PROCESSING	23	4.56e-01	5.53e-01	0.2100	-0.004390	-1.94e-01	0.080800	9.71e-01	1.07e-01	5.02e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	224	5.85e-07	7.74e-06	0.2100	-0.193000	-6.92e-02	-0.045200	6.60e-07	7.51e-02	2.45e-01
SPHINGOLIPID METABOLISM	72	1.29e-02	3.42e-02	0.2100	-0.096500	1.86e-01	0.001480	1.57e-01	6.30e-03	9.83e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	8.12e-02	1.44e-01	0.2090	-0.027300	-1.91e-01	-0.080300	7.83e-01	5.34e-02	4.18e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	23	4.28e-01	5.26e-01	0.2090	-0.188000	4.55e-02	-0.079800	1.19e-01	7.06e-01	5.08e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	80	3.44e-02	7.61e-02	0.2090	-0.071400	7.85e-02	-0.180000	2.70e-01	2.25e-01	5.39e-03
ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS	20	4.72e-01	5.65e-01	0.2090	-0.154000	-1.29e-01	0.058000	2.33e-01	3.20e-01	6.54e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	5.60e-01	6.43e-01	0.2090	-0.008030	1.45e-01	-0.150000	9.48e-01	2.39e-01	2.22e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	25	2.84e-01	3.85e-01	0.2090	-0.171000	-6.12e-02	-0.103000	1.38e-01	5.96e-01	3.74e-01
HEME SIGNALING	12	6.56e-01	7.21e-01	0.2090	0.095900	1.82e-01	-0.035100	5.65e-01	2.75e-01	8.33e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	4.74e-01	5.66e-01	0.2090	-0.110000	7.24e-02	-0.162000	3.62e-01	5.48e-01	1.79e-01
RNA POLYMERASE III TRANSCRIPTION	34	2.45e-01	3.44e-01	0.2080	0.196000	-3.52e-02	0.060500	4.82e-02	7.23e-01	5.42e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	60	5.41e-03	1.64e-02	0.2080	0.001270	-1.65e-01	-0.126000	9.86e-01	2.70e-02	9.09e-02
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	164	1.15e-04	7.11e-04	0.2080	-0.204000	-7.42e-04	-0.040800	6.99e-06	9.87e-01	3.68e-01
SYNAPTIC ADHESION LIKE MOLECULES	15	5.42e-01	6.27e-01	0.2080	-0.192000	3.08e-02	0.073900	1.99e-01	8.37e-01	6.20e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	16	5.14e-01	6.05e-01	0.2070	-0.184000	-6.35e-02	-0.070400	2.03e-01	6.60e-01	6.26e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	7.40e-01	7.91e-01	0.2070	-0.203000	2.91e-02	-0.021400	2.65e-01	8.74e-01	9.07e-01
CALCINEURIN ACTIVATES NFAT	10	5.95e-01	6.68e-01	0.2060	0.109000	-1.30e-01	-0.117000	5.49e-01	4.78e-01	5.21e-01
NEGATIVE REGULATION OF MAPK PATHWAY	41	1.67e-01	2.56e-01	0.2060	-0.177000	-8.45e-02	0.062000	4.95e-02	3.49e-01	4.92e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	139	5.81e-04	2.71e-03	0.2050	-0.204000	-1.22e-02	-0.018300	3.44e-05	8.04e-01	7.09e-01
SEPARATION OF SISTER CHROMATIDS	165	1.84e-04	1.05e-03	0.2050	-0.180000	1.59e-02	-0.095500	6.52e-05	7.25e-01	3.46e-02
GLYCOSPHINGOLIPID METABOLISM	42	6.71e-02	1.23e-01	0.2050	-0.102000	1.68e-01	0.058300	2.53e-01	6.02e-02	5.14e-01
MITOTIC METAPHASE AND ANAPHASE	202	3.04e-05	2.40e-04	0.2040	-0.180000	2.67e-02	-0.093500	1.09e-05	5.13e-01	2.23e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	66	8.92e-02	1.55e-01	0.2040	0.076500	1.30e-01	-0.137000	2.83e-01	6.71e-02	5.46e-02
TOLL LIKE RECEPTOR 4 TLR4 CASCADE	112	2.89e-03	1.01e-02	0.2040	-0.169000	-4.31e-04	-0.114000	2.08e-03	9.94e-01	3.70e-02
CA2 PATHWAY	37	6.17e-02	1.15e-01	0.2030	-0.019300	-1.68e-01	-0.113000	8.39e-01	7.70e-02	2.36e-01
TRANS GOLGI NETWORK VESICLE BUDDING	66	2.98e-02	6.73e-02	0.2030	-0.184000	7.90e-02	0.034300	9.82e-03	2.67e-01	6.30e-01
NUCLEAR ENVELOPE NE REASSEMBLY	61	5.85e-02	1.12e-01	0.2030	-0.185000	8.27e-02	-0.012700	1.25e-02	2.64e-01	8.64e-01
BASIGIN INTERACTIONS	18	5.30e-01	6.17e-01	0.2030	-0.075500	1.85e-01	-0.034900	5.79e-01	1.74e-01	7.98e-01
OXIDATIVE STRESS INDUCED SENESCENCE	37	1.21e-01	1.98e-01	0.2030	0.104000	-1.70e-01	-0.037300	2.73e-01	7.36e-02	6.95e-01
DNA DOUBLE STRAND BREAK RESPONSE	41	7.59e-02	1.36e-01	0.2030	0.126000	-6.29e-02	-0.146000	1.64e-01	4.86e-01	1.06e-01
INACTIVATION OF CSF3 G CSF SIGNALING	15	6.05e-01	6.78e-01	0.2020	-0.194000	-4.73e-02	0.028500	1.93e-01	7.51e-01	8.49e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	84	5.66e-03	1.70e-02	0.2020	-0.157000	-1.01e-01	-0.077200	1.31e-02	1.11e-01	2.22e-01
FC EPSILON RECEPTOR FCERI SIGNALING	110	1.94e-03	7.27e-03	0.2010	-0.175000	-9.34e-02	-0.034900	1.55e-03	9.08e-02	5.28e-01
FCERI MEDIATED MAPK ACTIVATION	26	2.41e-01	3.40e-01	0.2010	-0.118000	-7.43e-02	-0.145000	2.97e-01	5.12e-01	2.01e-01
SIGNALING BY NTRKS	73	3.28e-02	7.30e-02	0.2010	-0.197000	-2.55e-03	-0.041900	3.69e-03	9.70e-01	5.36e-01
REGULATION OF CDH11 EXPRESSION AND FUNCTION	11	6.53e-01	7.19e-01	0.2010	0.143000	1.35e-01	0.042400	4.13e-01	4.39e-01	8.07e-01
CLATHRIN MEDIATED ENDOCYTOSIS	120	3.88e-03	1.27e-02	0.2000	-0.186000	3.42e-02	-0.064100	4.42e-04	5.18e-01	2.26e-01
CARGO CONCENTRATION IN THE ER	29	2.70e-01	3.69e-01	0.1990	-0.159000	6.27e-03	0.120000	1.38e-01	9.53e-01	2.63e-01
DEADENYLATION DEPENDENT MRNA DECAY	48	4.27e-02	8.71e-02	0.1990	-0.054600	-1.81e-01	-0.062800	5.13e-01	3.03e-02	4.52e-01
CYCLIN D ASSOCIATED EVENTS IN G1	41	1.78e-01	2.69e-01	0.1990	-0.046400	3.10e-02	-0.191000	6.07e-01	7.32e-01	3.44e-02
MAPK FAMILY SIGNALING CASCADES	258	2.36e-06	2.59e-05	0.1980	-0.193000	3.24e-02	-0.028700	1.01e-07	3.71e-01	4.28e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	5.70e-01	6.50e-01	0.1980	0.072300	8.79e-02	-0.162000	5.76e-01	4.96e-01	2.11e-01
RHOJ GTPASE CYCLE	15	6.64e-01	7.25e-01	0.1970	0.137000	1.03e-01	-0.098300	3.60e-01	4.90e-01	5.10e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	51	5.92e-02	1.13e-01	0.1970	0.158000	-7.34e-02	-0.091100	5.05e-02	3.65e-01	2.61e-01
REGULATION OF TP53 DEGRADATION	34	1.42e-01	2.23e-01	0.1970	-0.114000	-9.29e-02	-0.131000	2.50e-01	3.49e-01	1.88e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	23	2.30e-01	3.28e-01	0.1960	0.031600	-1.54e-01	-0.117000	7.93e-01	2.00e-01	3.30e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	51	1.32e-01	2.13e-01	0.1960	-0.188000	4.46e-02	-0.035000	2.03e-02	5.82e-01	6.66e-01
RNA POLYMERASE II PROMOTER ESCAPE	44	2.11e-01	3.10e-01	0.1960	0.057000	-1.78e-01	0.059400	5.13e-01	4.16e-02	4.95e-01
NEDDYLATION	207	2.05e-04	1.14e-03	0.1950	-0.085500	-1.47e-01	0.096400	3.44e-02	2.75e-04	1.70e-02
MITOTIC PROPHASE	67	1.52e-02	3.88e-02	0.1950	-0.121000	-1.03e-01	-0.112000	8.58e-02	1.44e-01	1.12e-01
IRON UPTAKE AND TRANSPORT	46	2.80e-01	3.81e-01	0.1940	-0.007560	-1.18e-01	0.154000	9.29e-01	1.66e-01	7.15e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	12	7.96e-01	8.39e-01	0.1940	-0.043900	1.59e-01	-0.102000	7.92e-01	3.41e-01	5.42e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	171	3.51e-03	1.19e-02	0.1930	-0.042600	1.41e-01	-0.125000	3.38e-01	1.46e-03	4.89e-03
PHOSPHORYLATION OF THE APC C	19	5.72e-01	6.50e-01	0.1930	-0.182000	3.99e-02	-0.050600	1.69e-01	7.63e-01	7.02e-01
M PHASE	312	1.93e-07	2.95e-06	0.1930	-0.144000	1.05e-02	-0.128000	1.37e-05	7.51e-01	1.03e-04
MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL	164	1.56e-04	9.10e-04	0.1930	-0.113000	-1.46e-02	0.155000	1.25e-02	7.48e-01	6.22e-04
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	86	5.09e-02	1.00e-01	0.1920	-0.133000	7.82e-02	-0.114000	3.27e-02	2.10e-01	6.76e-02
IRS MEDIATED SIGNALLING	28	2.97e-01	3.97e-01	0.1920	-0.152000	-6.59e-02	-0.096700	1.65e-01	5.47e-01	3.76e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	4.24e-01	5.23e-01	0.1910	-0.138000	-3.41e-02	-0.129000	2.64e-01	7.82e-01	2.96e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	74	4.98e-03	1.54e-02	0.1910	-0.007120	-1.64e-01	-0.097200	9.16e-01	1.45e-02	1.48e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	79	5.32e-03	1.62e-02	0.1910	-0.044500	6.28e-02	0.175000	4.94e-01	3.35e-01	7.26e-03
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	90	3.26e-02	7.29e-02	0.1910	-0.160000	4.83e-02	-0.093100	8.91e-03	4.29e-01	1.27e-01
REGULATED PROTEOLYSIS OF P75NTR	10	7.01e-01	7.58e-01	0.1910	0.135000	1.04e-01	0.085700	4.59e-01	5.69e-01	6.39e-01
G ALPHA I SIGNALLING EVENTS	129	3.04e-03	1.05e-02	0.1910	-0.190000	3.00e-03	-0.014200	1.94e-04	9.53e-01	7.80e-01
DNA DOUBLE STRAND BREAK REPAIR	123	1.43e-03	5.58e-03	0.1910	0.044900	7.65e-03	-0.185000	3.90e-01	8.84e-01	3.93e-04
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	44	1.30e-01	2.11e-01	0.1910	-0.155000	-1.01e-01	-0.047700	7.58e-02	2.48e-01	5.85e-01
MITF M DEPENDENT GENE EXPRESSION	15	6.64e-01	7.25e-01	0.1910	-0.027400	-1.83e-01	0.047200	8.54e-01	2.21e-01	7.52e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	17	5.74e-01	6.52e-01	0.1900	0.065000	-1.00e-02	0.178000	6.43e-01	9.43e-01	2.04e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	26	3.04e-01	4.05e-01	0.1900	0.074500	-1.72e-01	-0.032100	5.11e-01	1.30e-01	7.77e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	33	3.28e-01	4.28e-01	0.1900	-0.108000	2.66e-02	-0.154000	2.84e-01	7.92e-01	1.27e-01
EGFR DOWNREGULATION	28	5.42e-01	6.27e-01	0.1890	-0.030600	1.24e-01	-0.140000	7.79e-01	2.56e-01	2.00e-01
RNA POLYMERASE I TRANSCRIPTION	41	8.11e-02	1.44e-01	0.1890	-0.068000	-1.43e-01	-0.103000	4.51e-01	1.13e-01	2.52e-01
SURFACTANT METABOLISM	14	5.58e-01	6.42e-01	0.1880	-0.104000	6.12e-02	0.143000	4.99e-01	6.92e-01	3.53e-01
PHOSPHOLIPID METABOLISM	157	2.43e-03	8.71e-03	0.1870	-0.116000	-1.12e-01	0.094600	1.19e-02	1.52e-02	4.12e-02
FORMATION OF TC NER PRE INCISION COMPLEX	49	1.57e-01	2.43e-01	0.1870	0.053200	-1.77e-01	0.030500	5.19e-01	3.22e-02	7.12e-01
MET ACTIVATES RAP1 AND RAC1	11	8.44e-01	8.79e-01	0.1860	-0.054000	1.16e-01	-0.135000	7.56e-01	5.06e-01	4.38e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	23	4.90e-01	5.80e-01	0.1860	-0.148000	-3.69e-02	0.106000	2.18e-01	7.60e-01	3.81e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	32	2.91e-01	3.92e-01	0.1850	0.148000	-5.76e-03	-0.112000	1.49e-01	9.55e-01	2.74e-01
G ALPHA 12 13 SIGNALLING EVENTS	69	1.28e-01	2.08e-01	0.1850	-0.106000	7.62e-02	-0.131000	1.27e-01	2.74e-01	5.98e-02
TOLL LIKE RECEPTOR CASCADES	138	4.63e-03	1.45e-02	0.1850	-0.157000	3.01e-02	-0.093100	1.51e-03	5.42e-01	5.94e-02
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	24	6.13e-01	6.83e-01	0.1840	0.067900	-1.36e-01	0.104000	5.65e-01	2.49e-01	3.76e-01
DUAL INCISION IN GG NER	41	1.02e-01	1.74e-01	0.1830	0.091800	-1.15e-01	-0.109000	3.09e-01	2.02e-01	2.29e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	12	6.07e-01	6.78e-01	0.1820	0.083700	-1.06e-01	-0.123000	6.16e-01	5.25e-01	4.62e-01
MITOTIC SPINDLE CHECKPOINT	96	5.33e-02	1.03e-01	0.1820	-0.104000	7.31e-02	-0.131000	7.95e-02	2.16e-01	2.71e-02
AZATHIOPRINE ADME	20	6.40e-01	7.06e-01	0.1820	0.046000	-1.63e-01	0.066800	7.22e-01	2.07e-01	6.05e-01
PROTEIN UBIQUITINATION	56	8.99e-02	1.56e-01	0.1820	-0.078700	-1.64e-01	-0.002630	3.08e-01	3.40e-02	9.73e-01
INSULIN RECEPTOR RECYCLING	24	4.52e-01	5.48e-01	0.1820	-0.151000	-4.71e-04	0.102000	2.02e-01	9.97e-01	3.88e-01
PKR MEDIATED SIGNALING	60	1.67e-01	2.56e-01	0.1810	-0.048700	1.63e-01	-0.064400	5.14e-01	2.95e-02	3.89e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	27	4.85e-01	5.78e-01	0.1810	0.165000	-4.98e-02	0.056000	1.37e-01	6.54e-01	6.15e-01
DEVELOPMENTAL BIOLOGY	316	1.52e-05	1.37e-04	0.1810	-0.128000	1.00e-01	-0.079900	9.87e-05	2.23e-03	1.49e-02
TRANSPORT OF SMALL MOLECULES	500	8.21e-10	1.54e-08	0.1810	-0.138000	-6.34e-02	0.097600	1.39e-07	1.58e-02	2.02e-04
PHASE I FUNCTIONALIZATION OF COMPOUNDS	56	2.69e-01	3.69e-01	0.1800	0.021300	-1.10e-01	0.141000	7.83e-01	1.55e-01	6.82e-02
ONCOGENE INDUCED SENESCENCE	16	5.47e-01	6.32e-01	0.1790	-0.014800	-4.10e-02	-0.173000	9.19e-01	7.77e-01	2.30e-01
GABA B RECEPTOR ACTIVATION	33	3.64e-01	4.64e-01	0.1790	-0.178000	-1.14e-02	0.007860	7.65e-02	9.10e-01	9.38e-01
PEPTIDE HORMONE METABOLISM	34	2.45e-01	3.44e-01	0.1790	-0.129000	4.23e-02	0.116000	1.94e-01	6.70e-01	2.41e-01
CHAPERONIN MEDIATED PROTEIN FOLDING	31	3.08e-01	4.09e-01	0.1790	-0.137000	-6.12e-02	-0.097000	1.87e-01	5.55e-01	3.50e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	24	3.02e-01	4.03e-01	0.1790	0.005040	-1.54e-01	-0.090300	9.66e-01	1.92e-01	4.44e-01
PEPTIDE LIGAND BINDING RECEPTORS	57	1.39e-01	2.22e-01	0.1780	-0.166000	-6.10e-02	0.020000	2.98e-02	4.26e-01	7.94e-01
MRNA SPLICING MINOR PATHWAY	47	3.20e-01	4.21e-01	0.1780	0.000563	-1.55e-01	0.087400	9.95e-01	6.57e-02	3.00e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	31	3.84e-01	4.80e-01	0.1780	-0.096000	1.49e-01	-0.017300	3.55e-01	1.51e-01	8.68e-01
MRNA CAPPING	28	4.67e-01	5.62e-01	0.1780	-0.031500	-1.69e-01	0.046000	7.73e-01	1.22e-01	6.74e-01
INTERFERON SIGNALING	115	2.42e-02	5.65e-02	0.1760	-0.118000	4.50e-02	-0.124000	2.96e-02	4.05e-01	2.23e-02
INSULIN RECEPTOR SIGNALLING CASCADE	33	2.34e-01	3.32e-01	0.1760	-0.090100	-7.13e-02	-0.134000	3.71e-01	4.79e-01	1.84e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	41	1.58e-01	2.44e-01	0.1760	0.032200	-3.37e-02	-0.170000	7.21e-01	7.09e-01	6.04e-02
NEGATIVE REGULATION OF FGFR4 SIGNALING	23	3.46e-01	4.46e-01	0.1760	0.021900	-1.54e-01	-0.080700	8.56e-01	2.00e-01	5.03e-01
CELLULAR RESPONSES TO STIMULI	420	3.13e-07	4.62e-06	0.1740	-0.086600	-1.35e-01	0.067600	2.42e-03	2.36e-06	1.79e-02
NICOTINATE METABOLISM	25	5.68e-01	6.49e-01	0.1740	-0.141000	4.18e-02	-0.091600	2.21e-01	7.18e-01	4.28e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	6.68e-01	7.27e-01	0.1730	-0.101000	8.24e-02	0.114000	5.44e-01	6.21e-01	4.93e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	27	5.00e-01	5.90e-01	0.1710	-0.004800	3.39e-02	-0.167000	9.66e-01	7.60e-01	1.32e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	36	2.20e-01	3.18e-01	0.1700	0.003550	-1.64e-01	-0.044600	9.71e-01	8.87e-02	6.44e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	12	7.69e-01	8.19e-01	0.1700	-0.055400	1.60e-01	-0.011400	7.40e-01	3.38e-01	9.45e-01
RHOBTB GTPASE CYCLE	34	4.90e-01	5.80e-01	0.1690	0.065200	8.75e-02	-0.130000	5.11e-01	3.78e-01	1.91e-01
SUMOYLATION	144	3.69e-03	1.25e-02	0.1690	0.026900	1.84e-02	-0.166000	5.78e-01	7.03e-01	5.88e-04
ATTENUATION PHASE	13	7.40e-01	7.91e-01	0.1690	0.112000	1.78e-02	0.125000	4.84e-01	9.12e-01	4.35e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND	46	2.78e-01	3.78e-01	0.1690	-0.131000	1.04e-01	-0.020200	1.24e-01	2.21e-01	8.13e-01
RAB REGULATION OF TRAFFICKING	109	1.34e-02	3.50e-02	0.1690	-0.126000	-1.10e-01	-0.020000	2.32e-02	4.72e-02	7.18e-01
SIGNALLING TO ERKS	25	4.70e-01	5.64e-01	0.1680	-0.128000	-4.59e-02	-0.099700	2.69e-01	6.91e-01	3.88e-01
VESICLE MEDIATED TRANSPORT	522	6.42e-09	1.13e-07	0.1670	-0.163000	2.01e-02	-0.033700	2.40e-10	4.35e-01	1.90e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	11	8.50e-01	8.83e-01	0.1670	0.094300	1.12e-01	-0.080100	5.88e-01	5.20e-01	6.46e-01
FGFR2 ALTERNATIVE SPLICING	17	7.15e-01	7.69e-01	0.1670	-0.116000	-5.36e-02	0.107000	4.07e-01	7.02e-01	4.44e-01
DEATH RECEPTOR SIGNALING	131	3.90e-02	8.23e-02	0.1670	0.004250	8.76e-02	-0.142000	9.33e-01	8.37e-02	5.12e-03
NOD1 2 SIGNALING PATHWAY	30	3.55e-01	4.55e-01	0.1660	-0.085200	-4.55e-02	-0.135000	4.19e-01	6.66e-01	1.99e-01
SIGNALING BY EGFR	43	3.76e-01	4.75e-01	0.1660	-0.082600	4.62e-02	-0.136000	3.49e-01	6.00e-01	1.23e-01
GENE SILENCING BY RNA	40	2.48e-01	3.46e-01	0.1650	0.035500	-1.60e-01	-0.017400	6.98e-01	7.98e-02	8.49e-01
FCERI MEDIATED CA 2 MOBILIZATION	23	5.16e-01	6.05e-01	0.1650	-0.054400	-1.57e-02	-0.155000	6.52e-01	8.96e-01	1.99e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	314	9.19e-06	8.89e-05	0.1650	-0.156000	-5.07e-02	-0.011200	2.10e-06	1.23e-01	7.33e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	2.60e-01	3.61e-01	0.1630	0.050700	-1.37e-01	-0.073300	6.15e-01	1.74e-01	4.66e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	7.04e-01	7.60e-01	0.1630	0.148000	-6.24e-02	-0.029000	3.06e-01	6.66e-01	8.41e-01
SIGNALLING TO RAS	12	7.78e-01	8.26e-01	0.1630	-0.123000	-1.05e-01	-0.017800	4.61e-01	5.29e-01	9.15e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	26	5.90e-01	6.65e-01	0.1620	-0.138000	2.48e-02	-0.081800	2.23e-01	8.27e-01	4.71e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	1.95e-01	2.91e-01	0.1620	0.116000	-5.82e-02	-0.097400	1.80e-01	5.00e-01	2.58e-01
BETA CATENIN PHOSPHORYLATION CASCADE	17	7.21e-01	7.74e-01	0.1620	-0.151000	-4.76e-02	0.035200	2.82e-01	7.34e-01	8.02e-01
PI3K EVENTS IN ERBB2 SIGNALING	13	7.67e-01	8.17e-01	0.1620	-0.139000	7.95e-02	0.024200	3.86e-01	6.20e-01	8.80e-01
ASPARAGINE N LINKED GLYCOSYLATION	241	3.10e-04	1.62e-03	0.1620	-0.162000	2.37e-03	0.004390	1.61e-05	9.50e-01	9.07e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	13	7.89e-01	8.33e-01	0.1620	0.076900	1.40e-01	-0.026200	6.31e-01	3.83e-01	8.70e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	14	7.97e-01	8.39e-01	0.1610	-0.131000	2.61e-02	-0.090500	3.96e-01	8.66e-01	5.58e-01
SNRNP ASSEMBLY	47	3.12e-01	4.14e-01	0.1610	0.049500	-1.50e-01	0.032300	5.58e-01	7.57e-02	7.01e-01
CHROMATIN MODIFYING ENZYMES	136	8.60e-04	3.76e-03	0.1610	-0.003600	-8.04e-02	-0.139000	9.42e-01	1.06e-01	5.16e-03
DEPOLYMERIZATION OF THE NUCLEAR LAMINA	11	8.46e-01	8.80e-01	0.1600	-0.155000	2.47e-02	-0.032000	3.73e-01	8.87e-01	8.54e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	107	3.69e-02	7.99e-02	0.1600	-0.155000	-3.83e-03	0.042100	5.79e-03	9.46e-01	4.53e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	73	5.04e-02	9.96e-02	0.1600	0.098000	-1.07e-01	-0.068400	1.48e-01	1.16e-01	3.13e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	135	5.68e-03	1.70e-02	0.1590	-0.091400	-1.28e-01	-0.022200	6.72e-02	1.01e-02	6.56e-01
CELLULAR RESPONSE TO HEAT STRESS	81	1.86e-01	2.80e-01	0.1580	-0.045000	-8.63e-02	0.124000	4.84e-01	1.80e-01	5.34e-02
DEUBIQUITINATION	216	1.06e-03	4.33e-03	0.1580	-0.139000	-4.69e-03	-0.075300	4.62e-04	9.06e-01	5.70e-02
METABOLISM OF PROTEINS	1445	1.15e-17	6.49e-16	0.1570	-0.081600	-1.06e-01	0.082000	3.21e-07	2.98e-11	2.77e-07
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	19	7.91e-01	8.35e-01	0.1570	-0.074500	1.01e-01	-0.093900	5.74e-01	4.46e-01	4.79e-01
RAF ACTIVATION	34	5.63e-01	6.45e-01	0.1560	-0.064300	-8.59e-02	0.114000	5.17e-01	3.86e-01	2.51e-01
METABOLISM OF CARBOHYDRATES	219	9.81e-04	4.10e-03	0.1560	-0.148000	4.83e-02	0.007860	1.60e-04	2.19e-01	8.42e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	81	3.96e-02	8.31e-02	0.1560	0.075200	-1.25e-01	-0.055500	2.42e-01	5.18e-02	3.88e-01
TELOMERE EXTENSION BY TELOMERASE	17	6.10e-01	6.80e-01	0.1550	0.073400	-1.15e-01	-0.074300	6.00e-01	4.13e-01	5.96e-01
ESR MEDIATED SIGNALING	102	5.19e-02	1.01e-01	0.1550	-0.110000	-3.61e-03	-0.109000	5.58e-02	9.50e-01	5.63e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	8.40e-01	8.76e-01	0.1550	0.001460	2.13e-02	-0.153000	9.93e-01	9.03e-01	3.78e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	82	1.20e-01	1.97e-01	0.1540	-0.154000	-8.64e-03	0.000127	1.61e-02	8.93e-01	9.98e-01
METABOLISM OF NUCLEOTIDES	77	2.69e-01	3.69e-01	0.1540	-0.000914	-1.11e-01	0.107000	9.89e-01	9.34e-02	1.04e-01
NEUREXINS AND NEUROLIGINS	21	5.26e-01	6.14e-01	0.1530	-0.023500	1.40e-01	0.058700	8.52e-01	2.67e-01	6.41e-01
UNFOLDED PROTEIN RESPONSE UPR	10	8.91e-01	9.17e-01	0.1500	-0.061600	3.33e-02	-0.132000	7.36e-01	8.55e-01	4.70e-01
INTERFERON GAMMA SIGNALING	18	5.83e-01	6.58e-01	0.1490	-0.022900	-1.15e-01	-0.092800	8.67e-01	3.99e-01	4.96e-01
REGULATION OF TP53 ACTIVITY	145	1.17e-02	3.11e-02	0.1490	-0.058700	-6.06e-03	-0.136000	2.23e-01	9.00e-01	4.62e-03
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	10	8.97e-01	9.20e-01	0.1480	0.103000	8.49e-02	-0.064400	5.73e-01	6.42e-01	7.24e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	254	1.14e-05	1.08e-04	0.1480	0.005840	-1.30e-01	-0.069000	8.73e-01	3.61e-04	5.89e-02
NOTCH HLH TRANSCRIPTION PATHWAY	22	6.67e-01	7.27e-01	0.1470	-0.071300	-8.36e-05	-0.129000	5.63e-01	9.99e-01	2.97e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	54	2.93e-01	3.93e-01	0.1470	0.028600	-1.43e-01	0.016200	7.17e-01	6.89e-02	8.37e-01
SIGNALING BY GPCR	323	3.86e-04	1.92e-03	0.1470	-0.128000	5.02e-02	-0.049500	7.64e-05	1.22e-01	1.27e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	68	2.14e-01	3.12e-01	0.1460	0.118000	-8.55e-02	0.002560	9.29e-02	2.23e-01	9.71e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	273	8.95e-04	3.84e-03	0.1450	-0.117000	-7.77e-02	0.038500	9.44e-04	2.76e-02	2.75e-01
REGULATION OF TNFR1 SIGNALING	46	3.78e-01	4.76e-01	0.1450	-0.079100	1.76e-03	-0.121000	3.54e-01	9.83e-01	1.56e-01
SIGNALING BY WNT	201	1.61e-03	6.23e-03	0.1440	-0.108000	-8.79e-02	-0.039000	8.62e-03	3.20e-02	3.42e-01
G ALPHA Q SIGNALLING EVENTS	116	7.34e-02	1.33e-01	0.1440	-0.126000	8.78e-03	-0.069200	1.94e-02	8.70e-01	1.98e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	2.94e-01	3.94e-01	0.1440	0.035300	-1.01e-01	-0.096100	7.10e-01	2.89e-01	3.12e-01
DUAL INCISION IN TC NER	61	1.75e-01	2.65e-01	0.1430	0.102000	-7.70e-02	-0.063300	1.68e-01	2.99e-01	3.92e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	130	1.37e-02	3.54e-02	0.1420	-0.082200	1.07e-01	0.046600	1.06e-01	3.62e-02	3.60e-01
CELLULAR SENESCENCE	91	3.42e-02	7.58e-02	0.1420	-0.024700	-7.58e-02	-0.118000	6.84e-01	2.12e-01	5.26e-02
TRANSCRIPTIONAL REGULATION BY RUNX1	120	3.50e-02	7.71e-02	0.1420	-0.104000	-3.76e-02	-0.088400	4.89e-02	4.78e-01	9.48e-02
GPCR LIGAND BINDING	139	4.30e-02	8.76e-02	0.1410	-0.140000	6.76e-03	-0.011700	4.32e-03	8.91e-01	8.13e-01
SIALIC ACID METABOLISM	25	6.78e-01	7.37e-01	0.1410	-0.137000	3.02e-02	0.007320	2.34e-01	7.94e-01	9.50e-01
STIMULI SENSING CHANNELS	62	3.49e-01	4.50e-01	0.1400	-0.070300	-5.53e-02	0.108000	3.39e-01	4.52e-01	1.42e-01
SIGNALING BY FGFR2	51	2.01e-01	2.99e-01	0.1400	-0.013100	-1.25e-01	-0.061200	8.71e-01	1.22e-01	4.50e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	93	1.20e-01	1.97e-01	0.1400	-0.107000	-1.11e-02	-0.088900	7.36e-02	8.53e-01	1.39e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	21	6.09e-01	6.80e-01	0.1390	-0.055100	-7.21e-02	-0.106000	6.62e-01	5.67e-01	4.02e-01
INOSITOL PHOSPHATE METABOLISM	42	3.40e-01	4.43e-01	0.1390	-0.092200	7.32e-02	0.073000	3.01e-01	4.12e-01	4.13e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	86	2.32e-01	3.28e-01	0.1380	0.010500	5.06e-02	-0.128000	8.66e-01	4.18e-01	4.02e-02
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	32	4.62e-01	5.57e-01	0.1370	0.045200	-1.23e-01	-0.042300	6.58e-01	2.30e-01	6.79e-01
MITF M REGULATED MELANOCYTE DEVELOPMENT	29	5.55e-01	6.39e-01	0.1370	-0.101000	-7.74e-02	-0.052500	3.49e-01	4.71e-01	6.25e-01
GENE EXPRESSION TRANSCRIPTION	921	4.84e-16	1.82e-14	0.1370	0.055600	-6.52e-02	-0.107000	4.60e-03	8.93e-04	5.54e-08
SIGNALING BY INSULIN RECEPTOR	56	3.43e-01	4.45e-01	0.1370	-0.128000	-3.33e-02	-0.033900	9.71e-02	6.67e-01	6.61e-01
NUCLEOTIDE EXCISION REPAIR	105	3.91e-02	8.25e-02	0.1370	0.073300	-9.93e-02	-0.058300	1.95e-01	7.90e-02	3.03e-01
GENERIC TRANSCRIPTION PATHWAY	690	7.88e-12	2.03e-10	0.1360	0.051500	-5.13e-02	-0.115000	2.19e-02	2.26e-02	2.85e-07
GLYCOSPHINGOLIPID CATABOLISM	28	5.42e-01	6.27e-01	0.1360	-0.059000	1.17e-01	0.038700	5.89e-01	2.85e-01	7.23e-01
MYD88 MAL TIRAP CASCADE INITIATED ON PLASMA MEMBRANE	81	1.10e-01	1.84e-01	0.1360	-0.087700	-6.41e-02	-0.082400	1.73e-01	3.19e-01	2.00e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	30	4.35e-01	5.34e-01	0.1360	-0.007090	-1.04e-01	-0.087200	9.46e-01	3.23e-01	4.09e-01
SIGNALING BY NOTCH1	18	8.11e-01	8.50e-01	0.1350	0.100000	3.95e-02	-0.081600	4.61e-01	7.72e-01	5.49e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	13	8.24e-01	8.61e-01	0.1350	-0.089900	9.48e-02	0.034600	5.75e-01	5.54e-01	8.29e-01
SIGNALING BY ERYTHROPOIETIN	16	8.78e-01	9.07e-01	0.1340	-0.086200	6.85e-02	-0.076400	5.51e-01	6.35e-01	5.97e-01
DNA DAMAGE RECOGNITION IN GG NER	38	5.29e-01	6.16e-01	0.1340	0.015900	-1.32e-01	0.012800	8.66e-01	1.59e-01	8.92e-01
RND2 GTPASE CYCLE	37	6.16e-01	6.84e-01	0.1340	0.052300	4.90e-02	-0.113000	5.82e-01	6.06e-01	2.36e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	89	1.47e-01	2.30e-01	0.1330	-0.121000	4.23e-02	0.036900	4.85e-02	4.91e-01	5.48e-01
INTERLEUKIN 17 SIGNALING	57	2.07e-01	3.06e-01	0.1320	-0.038100	-1.10e-01	-0.062400	6.19e-01	1.50e-01	4.16e-01
NUCLEOTIDE CATABOLISM	28	7.01e-01	7.58e-01	0.1320	-0.113000	-5.05e-02	0.046300	3.00e-01	6.44e-01	6.71e-01
RHOBTB2 GTPASE CYCLE	22	6.99e-01	7.58e-01	0.1320	0.031900	-6.68e-03	-0.128000	7.96e-01	9.57e-01	3.00e-01
GABA RECEPTOR ACTIVATION	37	5.95e-01	6.68e-01	0.1310	-0.130000	-2.60e-03	-0.015400	1.71e-01	9.78e-01	8.71e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	45	3.54e-01	4.55e-01	0.1290	-0.014100	1.21e-01	0.040700	8.70e-01	1.59e-01	6.37e-01
DNA REPAIR	257	9.47e-04	3.98e-03	0.1280	0.031400	-1.77e-02	-0.123000	3.87e-01	6.26e-01	7.37e-04
G ALPHA S SIGNALLING EVENTS	62	4.44e-01	5.42e-01	0.1270	-0.103000	3.10e-02	-0.067100	1.59e-01	6.73e-01	3.61e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	14	8.94e-01	9.20e-01	0.1260	-0.026600	3.40e-02	-0.118000	8.63e-01	8.26e-01	4.45e-01
SIGNALING BY FGFR1	41	5.12e-01	6.03e-01	0.1250	-0.004620	-1.41e-03	-0.125000	9.59e-01	9.87e-01	1.65e-01
MRNA SPLICING	190	3.76e-03	1.25e-02	0.1250	0.011400	-1.15e-01	-0.049400	7.86e-01	6.51e-03	2.41e-01
MET RECEPTOR RECYCLING	10	8.72e-01	9.02e-01	0.1250	-0.062200	8.38e-02	0.068800	7.33e-01	6.46e-01	7.06e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	28	7.26e-01	7.78e-01	0.1240	0.123000	-9.97e-03	-0.009060	2.59e-01	9.27e-01	9.34e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	11	8.83e-01	9.12e-01	0.1230	0.092400	-6.10e-02	-0.054300	5.96e-01	7.26e-01	7.55e-01
SIGNALING BY NUCLEAR RECEPTORS	144	5.73e-02	1.11e-01	0.1230	-0.087900	-8.53e-02	-0.011400	6.92e-02	7.76e-02	8.14e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	168	1.35e-02	3.50e-02	0.1220	-0.045100	3.88e-02	0.106000	3.14e-01	3.86e-01	1.79e-02
TRAFFICKING OF AMPA RECEPTORS	22	7.12e-01	7.68e-01	0.1210	-0.067100	8.81e-02	0.049600	5.86e-01	4.75e-01	6.87e-01
SPRY REGULATION OF FGF SIGNALING	16	8.21e-01	8.60e-01	0.1190	0.078400	-7.87e-02	-0.043700	5.87e-01	5.86e-01	7.62e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	13	8.84e-01	9.12e-01	0.1190	0.070800	1.88e-02	0.093400	6.59e-01	9.07e-01	5.60e-01
METABOLISM OF RNA	559	1.20e-05	1.11e-04	0.1160	-0.070900	-9.23e-02	-0.005500	4.39e-03	2.07e-04	8.25e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	32	7.71e-01	8.20e-01	0.1160	-0.045100	-9.58e-02	0.048500	6.59e-01	3.49e-01	6.35e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	65	2.96e-01	3.96e-01	0.1160	-0.067700	4.32e-02	0.083900	3.45e-01	5.47e-01	2.42e-01
REGULATION OF INSULIN SECRETION	49	5.95e-01	6.68e-01	0.1150	-0.110000	7.43e-03	-0.032000	1.81e-01	9.28e-01	6.98e-01
NONHOMOLOGOUS END JOINING NHEJ	31	7.49e-01	7.99e-01	0.1150	0.114000	-8.17e-03	0.005500	2.70e-01	9.37e-01	9.58e-01
GLUTAMATE AND GLUTAMINE METABOLISM	10	9.46e-01	9.59e-01	0.1140	-0.094100	-5.19e-02	0.036900	6.07e-01	7.76e-01	8.40e-01
ION TRANSPORT BY P TYPE ATPASES	41	7.20e-01	7.74e-01	0.1130	0.012200	1.03e-01	-0.046000	8.92e-01	2.54e-01	6.10e-01
TBC RABGAPS	33	7.99e-01	8.41e-01	0.1130	-0.039500	-8.30e-02	0.066500	6.95e-01	4.09e-01	5.09e-01
TRANSCRIPTIONAL REGULATION BY TP53	274	1.52e-03	5.88e-03	0.1090	-0.010900	-9.15e-02	-0.058500	7.56e-01	9.32e-03	9.62e-02
BASE EXCISION REPAIR	42	6.79e-01	7.38e-01	0.1090	0.042200	2.32e-02	-0.097400	6.36e-01	7.95e-01	2.75e-01
SIGNALING BY ROBO RECEPTORS	20	8.56e-01	8.87e-01	0.1080	-0.094000	-2.31e-02	-0.048300	4.67e-01	8.58e-01	7.08e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	11	9.18e-01	9.37e-01	0.1070	-0.043200	1.77e-02	0.096700	8.04e-01	9.19e-01	5.79e-01
TRANSCRIPTIONAL AND POST TRANSLATIONAL REGULATION OF MITF M EXPRESSION AND ACTIVITY	16	9.01e-01	9.24e-01	0.1060	-0.094700	-1.69e-02	-0.045000	5.12e-01	9.07e-01	7.55e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	23	8.50e-01	8.83e-01	0.1060	-0.101000	-2.34e-02	-0.017000	4.00e-01	8.46e-01	8.88e-01
RAB GERANYLGERANYLATION	52	6.35e-01	7.02e-01	0.1030	-0.097800	-3.19e-02	-0.004270	2.23e-01	6.91e-01	9.58e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	9.23e-01	9.42e-01	0.1030	0.102000	1.43e-02	0.004960	4.96e-01	9.24e-01	9.73e-01
INTEGRATION OF ENERGY METABOLISM	59	6.24e-01	6.91e-01	0.1020	-0.098300	1.67e-02	-0.022200	1.92e-01	8.24e-01	7.68e-01
NUCLEAR ENVELOPE BREAKDOWN	45	5.39e-01	6.26e-01	0.1020	-0.032300	-7.63e-02	-0.058800	7.08e-01	3.76e-01	4.95e-01
MYOGENESIS	17	9.43e-01	9.57e-01	0.1010	0.015700	6.54e-02	-0.075500	9.11e-01	6.40e-01	5.90e-01
NEURONAL SYSTEM	202	3.17e-02	7.10e-02	0.1010	-0.056200	4.20e-02	0.072800	1.69e-01	3.04e-01	7.50e-02
GAMMA CARBOXYLATION HYPUSINYLATION HYDROXYLATION AND ARYLSULFATASE ACTIVATION	45	7.47e-01	7.98e-01	0.1010	0.028200	-2.94e-02	0.092300	7.44e-01	7.33e-01	2.84e-01
SIGNALING BY ERBB2	40	8.01e-01	8.42e-01	0.1010	-0.069400	4.05e-02	-0.060900	4.48e-01	6.58e-01	5.05e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	62	6.39e-01	7.05e-01	0.0990	-0.010400	-9.42e-02	0.028700	8.88e-01	2.00e-01	6.96e-01
TNF SIGNALING	55	5.18e-01	6.07e-01	0.0983	-0.046000	-4.31e-02	-0.075500	5.55e-01	5.81e-01	3.33e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	38	7.88e-01	8.33e-01	0.0971	-0.025500	1.78e-02	-0.092000	7.86e-01	8.49e-01	3.26e-01
ION CHANNEL TRANSPORT	118	2.47e-01	3.46e-01	0.0956	-0.051900	1.39e-02	0.079100	3.31e-01	7.94e-01	1.38e-01
RESOLUTION OF ABASIC SITES AP SITES	37	8.34e-01	8.71e-01	0.0943	0.032400	3.86e-02	-0.079700	7.33e-01	6.85e-01	4.02e-01
BASE EXCISION REPAIR AP SITE FORMATION	15	9.11e-01	9.32e-01	0.0936	-0.065000	4.44e-02	0.050500	6.63e-01	7.66e-01	7.35e-01
ESTROGEN DEPENDENT GENE EXPRESSION	43	7.83e-01	8.29e-01	0.0923	0.076100	-5.13e-02	0.009730	3.88e-01	5.61e-01	9.12e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1089	2.76e-05	2.28e-04	0.0891	-0.086700	8.54e-04	-0.020500	1.78e-06	9.63e-01	2.60e-01
SIGNALING BY FGFR	62	6.16e-01	6.84e-01	0.0876	-0.043600	-1.83e-02	-0.073700	5.53e-01	8.04e-01	3.16e-01
PEXOPHAGY	10	9.56e-01	9.66e-01	0.0875	-0.030100	-7.87e-02	-0.023800	8.69e-01	6.67e-01	8.96e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	51	7.80e-01	8.27e-01	0.0832	-0.071100	-3.81e-03	-0.043100	3.80e-01	9.62e-01	5.95e-01
DOWNREGULATION OF ERBB2 SIGNALING	24	8.56e-01	8.87e-01	0.0818	-0.014200	4.40e-02	0.067500	9.04e-01	7.09e-01	5.67e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	9.75e-01	9.79e-01	0.0778	0.040700	9.39e-03	0.065700	8.24e-01	9.59e-01	7.19e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	22	9.36e-01	9.54e-01	0.0771	-0.071300	-2.77e-02	-0.009500	5.63e-01	8.22e-01	9.39e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	29	9.48e-01	9.59e-01	0.0764	-0.019300	5.39e-02	-0.050500	8.57e-01	6.15e-01	6.38e-01
THE PHOTOTRANSDUCTION CASCADE	17	9.60e-01	9.69e-01	0.0739	-0.067800	-2.77e-02	-0.009290	6.28e-01	8.43e-01	9.47e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	26	9.37e-01	9.54e-01	0.0735	-0.072800	8.56e-03	-0.005740	5.21e-01	9.40e-01	9.60e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	14	9.66e-01	9.73e-01	0.0720	0.056100	3.81e-02	0.024300	7.16e-01	8.05e-01	8.75e-01
SIGNALING BY NOTCH	38	8.12e-01	8.51e-01	0.0717	-0.007360	-5.44e-02	-0.046100	9.37e-01	5.62e-01	6.23e-01
RNA POLYMERASE II PRE TRANSCRIPTION EVENTS	72	6.69e-01	7.28e-01	0.0688	-0.025900	-5.01e-02	-0.039300	7.05e-01	4.62e-01	5.64e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	9.71e-01	9.76e-01	0.0664	0.043800	2.34e-03	-0.049900	7.61e-01	9.87e-01	7.30e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	19	9.39e-01	9.55e-01	0.0662	-0.010800	-4.41e-02	-0.048200	9.35e-01	7.39e-01	7.16e-01
CELL CELL JUNCTION ORGANIZATION	37	9.48e-01	9.59e-01	0.0634	0.019100	5.13e-02	-0.032000	8.41e-01	5.90e-01	7.36e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	40	8.96e-01	9.20e-01	0.0628	0.049100	-2.08e-02	-0.033300	5.91e-01	8.20e-01	7.16e-01
RET SIGNALING	34	9.63e-01	9.71e-01	0.0622	0.002100	-4.32e-02	0.044700	9.83e-01	6.63e-01	6.52e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	49	9.13e-01	9.33e-01	0.0618	-0.056000	2.37e-02	-0.011100	4.98e-01	7.74e-01	8.93e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	30	9.44e-01	9.58e-01	0.0542	-0.002300	5.17e-02	0.016000	9.83e-01	6.24e-01	8.80e-01
ADHERENS JUNCTIONS INTERACTIONS	29	9.79e-01	9.83e-01	0.0517	-0.034900	2.16e-02	-0.031300	7.45e-01	8.40e-01	7.70e-01
PURINE CATABOLISM	16	9.90e-01	9.91e-01	0.0456	0.037800	1.76e-02	0.018500	7.94e-01	9.03e-01	8.98e-01
SIGNALING BY ERBB4	32	9.89e-01	9.91e-01	0.0368	0.030800	-5.76e-03	0.019400	7.63e-01	9.55e-01	8.50e-01
EFFECTS OF PIP2 HYDROLYSIS	22	9.99e-01	9.99e-01	0.0181	0.004320	-9.08e-04	-0.017500	9.72e-01	9.94e-01	8.87e-01

---

Detailed Gene set reports

ENDOSOMAL VACUOLAR PATHWAY

ENDOSOMAL VACUOLAR PATHWAY

metric	value
setSize	10
pMANOVA	7.64e-08
p.adjustMANOVA	1.21e-06
s.dist	1.23
s.wt_gal3ko	-0.685
s.wt_mst1ox	0.55
s.mst1ox_mst1oxk	-0.863
p.wt_gal3ko	0.000174
p.wt_mst1ox	0.0026
p.mst1ox_mst1oxk	2.26e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_gal3ko
H2-T22	-7408	-7126.5
H2-T23	-7168	-7213.5
H2-Q4	-7396	-6576.5
H2-K1	-7407	-6356.5
H2-Q6	-7424	-6315.5
B2m	-7409	-5962.5
H2-Q7	-7417	-5203.5
H2-M3	-6202	-5646.5
H2-T10	-5883	-2083.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
B2m	-5962.5	4814.5	-7409
H2-K1	-6356.5	4150.5	-7407
H2-M3	-5646.5	1899.5	-6202
H2-Q4	-6576.5	2988.5	-7396
H2-Q6	-6315.5	3177.5	-7424
H2-Q7	-5203.5	3208.5	-7417
H2-T10	-2083.5	3758.5	-5883
H2-T22	-7126.5	5423.5	-7408
H2-T23	-7213.5	6309.5	-7168
Lnpep	1013.5	4396.5	-129

---

---

COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS

metric	value
setSize	58
pMANOVA	5.31e-39
p.adjustMANOVA	9.55e-37
s.dist	1.2
s.wt_gal3ko	0.189
s.wt_mst1ox	-0.907
s.mst1ox_mst1oxk	0.766
p.wt_gal3ko	0.013
p.wt_mst1ox	5.55e-33
p.mst1ox_mst1oxk	5.14e-24

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Ndufab1	-7698.5	7795
Ndufa5	-7746.5	7598
Ndufv2	-7672.5	7671
Hspa9	-7763.5	7433
Ndufs3	-7686.5	7485
Ndufa9	-7782.5	7325
Ndufa3	-7593.5	7391
Ndufb8	-7633.5	7300
Ndufs2	-7619.5	7313
Ndufs1	-7645.5	7271
Ndufa6	-7318.5	7568
Ndufc2	-7249.5	7618
Ndufa12	-7375.5	7479
Ndufs4	-7515.5	7323
Ndufc1	-7471.5	7364
mt-Nd6	-7086.5	7753
Ndufv3	-7479.5	7277
Ndufs6	-7679.5	7038
Ndufb9	-7407.5	7100
Ndufb11	-7286.5	7141

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acad9	-5597.5	-7087.5	6468
Ecsit	1659.5	-6589.5	6750
Hscb	5957.5	-6041.5	3248
Hspa9	-12.5	-7763.5	7433
Lyrm2	328.5	-4015.5	4990
mt-Nd1	3766.5	-7122.5	4753
mt-Nd2	4362.5	-7092.5	4128
mt-Nd4	6285.5	-7111.5	4527
mt-Nd5	4498.5	-7241.5	5023
mt-Nd6	3913.5	-7086.5	7753
Ndufa1	5462.5	-6839.5	6200
Ndufa10	-5319.5	-7685.5	6701
Ndufa11	2449.5	-6409.5	5296
Ndufa12	5960.5	-7375.5	7479
Ndufa13	5603.5	-7073.5	7147
Ndufa2	-645.5	-6183.5	4733
Ndufa3	6116.5	-7593.5	7391
Ndufa5	6989.5	-7746.5	7598
Ndufa6	4761.5	-7318.5	7568
Ndufa7	6460.5	-6304.5	6533
Ndufa8	-3066.5	-7188.5	6448
Ndufa9	-33.5	-7782.5	7325
Ndufab1	6903.5	-7698.5	7795
Ndufaf1	-4232.5	-7486.5	4589
Ndufaf2	1580.5	-5313.5	4693
Ndufaf3	-3734.5	-5604.5	6988
Ndufaf4	3053.5	-7224.5	5800
Ndufaf5	5220.5	-6466.5	4473
Ndufaf6	-3002.5	-7110.5	5517
Ndufaf7	-1322.5	-6810.5	4809
Ndufb10	-6588.5	-7326.5	6806
Ndufb11	6547.5	-7286.5	7141
Ndufb2	-879.5	-7475.5	3010
Ndufb3	-6198.5	-6925.5	6767
Ndufb4	6699.5	-7406.5	5756
Ndufb5	4917.5	-7136.5	6842
Ndufb6	-2328.5	-7304.5	5799
Ndufb7	-6.5	-6145.5	4947
Ndufb8	3157.5	-7633.5	7300
Ndufb9	2503.5	-7407.5	7100
Ndufc1	4333.5	-7471.5	7364
Ndufc2	6036.5	-7249.5	7618
Ndufs1	1820.5	-7645.5	7271
Ndufs2	-2710.5	-7619.5	7313
Ndufs3	3544.5	-7686.5	7485
Ndufs4	1522.5	-7515.5	7323
Ndufs5	-6770.5	-7258.5	5100
Ndufs6	5133.5	-7679.5	7038
Ndufs7	1093.5	-6951.5	6749
Ndufs8	2746.5	-7417.5	6993
Ndufv1	-1526.5	-6933.5	5612
Ndufv2	6092.5	-7672.5	7671
Ndufv3	1321.5	-7479.5	7277
Nubpl	-3830.5	-7043.5	4394
Pyurf	6987.5	-7020.5	-3016
Timmdc1	-4646.5	-5878.5	7284
Tmem126b	-2314.5	-7010.5	3220
Tmem186	-3589.5	-7569.5	4437

---

---

PROTEIN LIPOYLATION

PROTEIN LIPOYLATION

metric	value
setSize	10
pMANOVA	1.19e-06
p.adjustMANOVA	1.43e-05
s.dist	1.19
s.wt_gal3ko	0.0319
s.wt_mst1ox	-0.855
s.mst1ox_mst1oxk	0.821
p.wt_gal3ko	0.862
p.wt_mst1ox	2.8e-06
p.mst1ox_mst1oxk	6.85e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Ndufab1	-7698.5	7795
Dlst	-7780.5	7607
Dlat	-7564.5	7734
Dbt	-7745.5	7077
Lias	-6562.5	6695
Lipt2	-6170.5	6936
Fdx1	-6717.5	6090
Gcsh	-5471.5	6168
Lipt1	-5283.5	4772
Nfu1	-5925.5	3621

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Dbt	1472.5	-7745.5	7077
Dlat	-2899.5	-7564.5	7734
Dlst	-1944.5	-7780.5	7607
Fdx1	83.5	-6717.5	6090
Gcsh	-6962.5	-5471.5	6168
Lias	2747.5	-6562.5	6695
Lipt1	4081.5	-5283.5	4772
Lipt2	-1634.5	-6170.5	6936
Ndufab1	6903.5	-7698.5	7795
Nfu1	1324.5	-5925.5	3621

---

---

COMPLEX III ASSEMBLY

COMPLEX III ASSEMBLY

metric	value
setSize	17
pMANOVA	4.92e-11
p.adjustMANOVA	1.13e-09
s.dist	1.18
s.wt_gal3ko	0.264
s.wt_mst1ox	-0.829
s.mst1ox_mst1oxk	0.802
p.wt_gal3ko	0.0592
p.wt_mst1ox	3.21e-09
p.mst1ox_mst1oxk	1e-08

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Hspa9	-7763.5	7433
Uqcrc2	-7665.5	7441
Uqcrfs1	-7690.5	7145
Cyc1	-7255.5	6957
Nfs1	-7228.5	6950
Uqcrc1	-7436.5	6703
Uqcrh	-6804.5	7305
Uqcrq	-7130.5	6935
Uqcrb	-7102.5	6620
Lyrm7	-6367.5	7272
Iscu	-6425.5	6727
mt-Cytb	-7373.5	5778
Ttc19	-7345.5	4223
Uqcr10	-4460.5	5424
Fxn	-6225.5	3804
Hscb	-6041.5	3248

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Cyc1	3210.5	-7255.5	6957
Fxn	2418.5	-6225.5	3804
Hscb	5957.5	-6041.5	3248
Hspa9	-12.5	-7763.5	7433
Iscu	-3993.5	-6425.5	6727
Lyrm4	2645.5	2.5	7182
Lyrm7	305.5	-6367.5	7272
mt-Cytb	4254.5	-7373.5	5778
Nfs1	-2948.5	-7228.5	6950
Ttc19	-3230.5	-7345.5	4223
Uqcr10	5053.5	-4460.5	5424
Uqcrb	6093.5	-7102.5	6620
Uqcrc1	917.5	-7436.5	6703
Uqcrc2	3455.5	-7665.5	7441
Uqcrfs1	1348.5	-7690.5	7145
Uqcrh	3517.5	-6804.5	7305
Uqcrq	6492.5	-7130.5	6935

---

---

BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM

metric	value
setSize	20
pMANOVA	5.57e-13
p.adjustMANOVA	1.62e-11
s.dist	1.18
s.wt_gal3ko	0.164
s.wt_mst1ox	-0.884
s.mst1ox_mst1oxk	0.768
p.wt_gal3ko	0.204
p.wt_mst1ox	7.67e-12
p.mst1ox_mst1oxk	2.75e-09

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Hibadh	-7779.5	7698
Mccc2	-7760.5	7683
Bckdhb	-7658.5	7628
Aldh6a1	-7740.5	7544
Acat1	-7712.5	7394
Echs1	-7736.5	7365
Ivd	-7765.5	7279
Mccc1	-7768.5	7167
Bcat2	-7659.5	7248
Hsd17b10	-7548.5	7282
Dbt	-7745.5	7077
Auh	-7718.5	6944
Ppm1k	-7576.5	6473
Hibch	-7059.5	6796
Acadsb	-7324.5	5315
Bckdha	-7472.5	5097
Bckdk	-6695.5	4884
Dld	-7624.5	3955
Acad8	-7270.5	1682

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acad8	-7066.5	-7270.5	1682
Acadsb	4777.5	-7324.5	5315
Acat1	-6035.5	-7712.5	7394
Aldh6a1	4402.5	-7740.5	7544
Auh	6278.5	-7718.5	6944
Bcat1	5137.5	5557.5	-1759
Bcat2	-5140.5	-7659.5	7248
Bckdha	-7005.5	-7472.5	5097
Bckdhb	7550.5	-7658.5	7628
Bckdk	827.5	-6695.5	4884
Dbt	1472.5	-7745.5	7077
Dld	3637.5	-7624.5	3955
Echs1	7197.5	-7736.5	7365
Hibadh	3174.5	-7779.5	7698
Hibch	-3834.5	-7059.5	6796
Hsd17b10	5639.5	-7548.5	7282
Ivd	-5136.5	-7765.5	7279
Mccc1	7359.5	-7768.5	7167
Mccc2	-4217.5	-7760.5	7683
Ppm1k	7441.5	-7576.5	6473

---

---

CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE

metric	value
setSize	33
pMANOVA	1.62e-20
p.adjustMANOVA	1.32e-18
s.dist	1.15
s.wt_gal3ko	0.155
s.wt_mst1ox	-0.886
s.mst1ox_mst1oxk	0.723
p.wt_gal3ko	0.123
p.wt_mst1ox	1.14e-18
p.mst1ox_mst1oxk	6.56e-13

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Suclg1	-7732.5	7756
Sdha	-7707.5	7752
Dlst	-7780.5	7607
Idh3a	-7727.5	7496
Sdhc	-7541.5	7674
Idh3b	-7678.5	7521
Acat1	-7712.5	7394
Isca2	-7257.5	7749
Nnt	-7680.5	7212
Cs	-7694.5	7139
Sdhb	-7531.5	7210
Isca1	-7518.5	7203
Sdhd	-7560.5	7099
Fh1	-7529.5	7090
Nfs1	-7228.5	6950
Sirt3	-7200.5	6919
Idh3g	-7349.5	6575
Suclg2	-7708.5	5754
Iscu	-6425.5	6727
Mdh2	-7289.5	5846

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acat1	-6035.5	-7712.5	7394
Aco2	3846.5	-7213.5	2934
Cs	2593.5	-7694.5	7139
Dld	3637.5	-7624.5	3955
Dlst	-1944.5	-7780.5	7607
Fh1	2897.5	-7529.5	7090
Fxn	2418.5	-6225.5	3804
Idh2	-1028.5	-7309.5	410
Idh3a	6168.5	-7727.5	7496
Idh3b	3780.5	-7678.5	7521
Idh3g	4301.5	-7349.5	6575
Isca1	2229.5	-7518.5	7203
Isca2	3062.5	-7257.5	7749
Iscu	-3993.5	-6425.5	6727
Lyrm4	2645.5	2.5	7182
Mdh2	-58.5	-7289.5	5846
Mrps36	4641.5	-5338.5	5081
Nfs1	-2948.5	-7228.5	6950
Nnt	6104.5	-7680.5	7212
Ogdh	2118.5	-7608.5	4780
Sdha	3963.5	-7707.5	7752
Sdhaf1	-828.5	-4776.5	3263
Sdhaf2	-3479.5	-6848.5	538
Sdhaf3	566.5	-4898.5	4556
Sdhaf4	-1357.5	-5833.5	6482
Sdhb	2919.5	-7531.5	7210
Sdhc	4079.5	-7541.5	7674
Sdhd	3291.5	-7560.5	7099
Sirt3	5215.5	-7200.5	6919
Sucla2	-7502.5	-7638.5	-1120
Suclg1	763.5	-7732.5	7756
Suclg2	-47.5	-7708.5	5754
Trap1	-629.5	-7141.5	3221

---

---

RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT

metric	value
setSize	124
pMANOVA	1.52e-74
p.adjustMANOVA	4.56e-72
s.dist	1.14
s.wt_gal3ko	0.206
s.wt_mst1ox	-0.843
s.mst1ox_mst1oxk	0.734
p.wt_gal3ko	7.71e-05
p.wt_mst1ox	1.76e-59
p.mst1ox_mst1oxk	2.2e-45

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Ndufab1	-7698.5	7795
Cox7a1	-7777.5	7707
Cox5a	-7703.5	7763
Ndufa5	-7746.5	7598
Ndufv2	-7672.5	7671
Etfdh	-7786.5	7551
Got1	-7644.5	7659
Etfa	-7766.5	7536
Hspa9	-7763.5	7433
Ndufs3	-7686.5	7485
Uqcrc2	-7665.5	7441
Ndufa9	-7782.5	7325
Ndufa3	-7593.5	7391
Slc25a11	-7635.5	7339
Etfb	-7567.5	7388
Ndufb8	-7633.5	7300
Ndufs2	-7619.5	7313
Ndufs1	-7645.5	7271
Ndufa6	-7318.5	7568
Ndufc2	-7249.5	7618

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acad9	-5597.5	-7087.5	6468
Cmc1	2153.5	-4408.5	2058
Coa3	997.5	-3139.5	6848
Coa5	-4039.5	-6192.5	7335
Coq10a	-3836.5	-7397.5	7308
Coq10b	-7241.5	-2572.5	-6920
Cox11	-2891.5	-6690.5	7179
Cox14	-1993.5	-5886.5	5188
Cox15	4284.5	-7202.5	3896
Cox16	5656.5	30.5	-1138
Cox17	-470.5	-4322.5	-2893
Cox18	700.5	-4414.5	5641
Cox19	-7216.5	6776.5	6395
Cox20	7001.5	-5404.5	5609
Cox4i1	4003.5	-7294.5	6927
Cox4i2	-1032.5	-5203.5	4474
Cox5a	2217.5	-7703.5	7763
Cox5b	5346.5	-7225.5	7063
Cox6a1	6639.5	-3949.5	5470
Cox6a2	6445.5	-6766.5	6971
Cox6b1	6311.5	-6861.5	6566
Cox6b2	-204.5	-5595.5	6234
Cox6c	7497.5	-7238.5	6748
Cox7a1	1712.5	-7777.5	7707
Cox7a2	6943.5	-6681.5	6780
Cox7a2l	-6219.5	-6879.5	6385
Cox7b	5727.5	-7157.5	5006
Cox7c	6517.5	-7135.5	6726
Cox8a	5767.5	-1185.5	2548
Cyc1	3210.5	-7255.5	6957
Cycs	3494.5	-7336.5	6637
Ecsit	1659.5	-6589.5	6750
Etfa	235.5	-7766.5	7536
Etfb	1414.5	-7567.5	7388
Etfdh	-1532.5	-7786.5	7551
Fxn	2418.5	-6225.5	3804
Got1	391.5	-7644.5	7659
Got2	4061.5	-6959.5	5656
Hccs	4669.5	-6749.5	3299
Higd1a	-5762.5	-7160.5	5218
Higd2a	5434.5	-5562.5	2837
Hscb	5957.5	-6041.5	3248
Hspa9	-12.5	-7763.5	7433
Iscu	-3993.5	-6425.5	6727
Lyrm2	328.5	-4015.5	4990
Lyrm4	2645.5	2.5	7182
Lyrm7	305.5	-6367.5	7272
Mdh1	3724.5	-7342.5	7413
Mdh2	-58.5	-7289.5	5846
mt-Co1	3401.5	-7341.5	2990
mt-Cytb	4254.5	-7373.5	5778
mt-Nd1	3766.5	-7122.5	4753
mt-Nd2	4362.5	-7092.5	4128
mt-Nd4	6285.5	-7111.5	4527
mt-Nd5	4498.5	-7241.5	5023
mt-Nd6	3913.5	-7086.5	7753
Ndufa1	5462.5	-6839.5	6200
Ndufa10	-5319.5	-7685.5	6701
Ndufa11	2449.5	-6409.5	5296
Ndufa12	5960.5	-7375.5	7479
Ndufa13	5603.5	-7073.5	7147
Ndufa2	-645.5	-6183.5	4733
Ndufa3	6116.5	-7593.5	7391
Ndufa4	5691.5	-7281.5	7259
Ndufa5	6989.5	-7746.5	7598
Ndufa6	4761.5	-7318.5	7568
Ndufa7	6460.5	-6304.5	6533
Ndufa8	-3066.5	-7188.5	6448
Ndufa9	-33.5	-7782.5	7325
Ndufab1	6903.5	-7698.5	7795
Ndufaf1	-4232.5	-7486.5	4589
Ndufaf2	1580.5	-5313.5	4693
Ndufaf3	-3734.5	-5604.5	6988
Ndufaf4	3053.5	-7224.5	5800
Ndufaf5	5220.5	-6466.5	4473
Ndufaf6	-3002.5	-7110.5	5517
Ndufaf7	-1322.5	-6810.5	4809
Ndufb10	-6588.5	-7326.5	6806
Ndufb11	6547.5	-7286.5	7141
Ndufb2	-879.5	-7475.5	3010
Ndufb3	-6198.5	-6925.5	6767
Ndufb4	6699.5	-7406.5	5756
Ndufb5	4917.5	-7136.5	6842
Ndufb6	-2328.5	-7304.5	5799
Ndufb7	-6.5	-6145.5	4947
Ndufb8	3157.5	-7633.5	7300
Ndufb9	2503.5	-7407.5	7100
Ndufc1	4333.5	-7471.5	7364
Ndufc2	6036.5	-7249.5	7618
Ndufs1	1820.5	-7645.5	7271
Ndufs2	-2710.5	-7619.5	7313
Ndufs3	3544.5	-7686.5	7485
Ndufs4	1522.5	-7515.5	7323
Ndufs5	-6770.5	-7258.5	5100
Ndufs6	5133.5	-7679.5	7038
Ndufs7	1093.5	-6951.5	6749
Ndufs8	2746.5	-7417.5	6993
Ndufv1	-1526.5	-6933.5	5612
Ndufv2	6092.5	-7672.5	7671
Ndufv3	1321.5	-7479.5	7277
Nfs1	-2948.5	-7228.5	6950
Nubpl	-3830.5	-7043.5	4394
Pyurf	6987.5	-7020.5	-3016
Sco1	-6499.5	-6709.5	4955
Sco2	4606.5	-4574.5	2341
Slc25a11	3051.5	-7635.5	7339
Slc25a12	-885.5	-7434.5	6617
Slc25a13	-5672.5	-6901.5	2617
Slc25a22	4124.5	-6352.5	5634
Smim20	4794.5	-6760.5	6396
Surf1	-4188.5	-6162.5	2712
Timm21	3881.5	-7163.5	4021
Timmdc1	-4646.5	-5878.5	7284
Tmem126b	-2314.5	-7010.5	3220
Tmem177	6019.5	-7334.5	6754
Tmem186	-3589.5	-7569.5	4437
Ttc19	-3230.5	-7345.5	4223
Uqcr10	5053.5	-4460.5	5424
Uqcrb	6093.5	-7102.5	6620
Uqcrc1	917.5	-7436.5	6703
Uqcrc2	3455.5	-7665.5	7441
Uqcrfs1	1348.5	-7690.5	7145
Uqcrh	3517.5	-6804.5	7305
Uqcrq	6492.5	-7130.5	6935

---

---

MITOCHONDRIAL FATTY ACID BETA OXIDATION

MITOCHONDRIAL FATTY ACID BETA OXIDATION

metric	value
setSize	33
pMANOVA	8.22e-19
p.adjustMANOVA	5.28e-17
s.dist	1.11
s.wt_gal3ko	0.0558
s.wt_mst1ox	-0.824
s.mst1ox_mst1oxk	0.739
p.wt_gal3ko	0.579
p.wt_mst1ox	2.49e-16
p.mst1ox_mst1oxk	2.01e-13

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Acaa2	-7778.5	7776
Ndufab1	-7698.5	7795
Decr1	-7775.5	7676
Mcee	-7737.5	7629
Acad11	-7683.5	7542
Acot1	-7501.5	7716
Hadh	-7789.5	7375
Eci1	-7725.5	7431
Acadl	-7537.5	7571
Echs1	-7736.5	7365
Acadvl	-7505.5	7533
Hadha	-7666.5	7199
Acot11	-7114.5	7748
Acot2	-7351.5	7256
Acot13	-7171.5	7260
Hadhb	-7756.5	6673
Acadm	-7609.5	6761
Pcca	-7764.5	6554
Mecr	-6977.5	7243
Dbi	-6864.5	7340

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acaa2	2735.5	-7778.5	7776
Acad10	4782.5	-5108.5	7244
Acad11	-4631.5	-7683.5	7542
Acadl	-56.5	-7537.5	7571
Acadm	37.5	-7609.5	6761
Acads	-6420.5	-7234.5	6702
Acadvl	1173.5	-7505.5	7533
Acbd6	2080.5	-2964.5	3326
Acot1	6765.5	-7501.5	7716
Acot11	3418.5	-7114.5	7748
Acot12	-2021.5	301.5	3397
Acot13	-2639.5	-7171.5	7260
Acot2	-2155.5	-7351.5	7256
Acot3	3092.5	-6542.5	1109
Acot7	-716.5	-7098.5	3484
Acot9	-1642.5	6907.5	-2957
Acsf2	-4501.5	-7192.5	6454
Dbi	-3442.5	-6864.5	7340
Decr1	2758.5	-7775.5	7676
Echs1	7197.5	-7736.5	7365
Eci1	3926.5	-7725.5	7431
Hadh	-934.5	-7789.5	7375
Hadha	1680.5	-7666.5	7199
Hadhb	1340.5	-7756.5	6673
Mcat	-2902.5	-6705.5	5398
Mcee	7083.5	-7737.5	7629
Mecr	6812.5	-6977.5	7243
Mmaa	1952.5	-6835.5	7123
Ndufab1	6903.5	-7698.5	7795
Pcca	-3076.5	-7764.5	6554
Pccb	-4333.5	-7517.5	2577
Pctp	-4551.5	-6133.5	3922
Them4	-3246.5	-5719.5	-3435

---

---

UBIQUINOL BIOSYNTHESIS

UBIQUINOL BIOSYNTHESIS

metric	value
setSize	11
pMANOVA	6.39e-07
p.adjustMANOVA	8.21e-06
s.dist	1.1
s.wt_gal3ko	-0.292
s.wt_mst1ox	-0.875
s.mst1ox_mst1oxk	0.602
p.wt_gal3ko	0.0942
p.wt_mst1ox	5.03e-07
p.mst1ox_mst1oxk	0.000547

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Coq9	-7557.5	7535
Stard7	-7598.5	7356
Coq3	-7352.5	7383
Coq5	-7654.5	6850
Coq6	-7492.5	6315
Coq2	-7455.5	6111
Pdss1	-7180.5	3645
Coq7	-6668.5	3123
Pdss2	-7442.5	2391
Coq4	-5872.5	1422
Hpdl	-2965.5	422

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Coq2	-14.5	-7455.5	6111
Coq3	-3240.5	-7352.5	7383
Coq4	-2876.5	-5872.5	1422
Coq5	-4802.5	-7654.5	6850
Coq6	-3812.5	-7492.5	6315
Coq7	-3193.5	-6668.5	3123
Coq9	-2166.5	-7557.5	7535
Hpdl	3316.5	-2965.5	422
Pdss1	-4319.5	-7180.5	3645
Pdss2	-4692.5	-7442.5	2391
Stard7	2197.5	-7598.5	7356

---

---

MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE

MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE

metric	value
setSize	18
pMANOVA	3.45e-10
p.adjustMANOVA	7.05e-09
s.dist	1.1
s.wt_gal3ko	0.0965
s.wt_mst1ox	-0.829
s.mst1ox_mst1oxk	0.718
p.wt_gal3ko	0.478
p.wt_mst1ox	1.12e-09
p.mst1ox_mst1oxk	1.34e-07

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Sdha	-7707.5	7752
Sdhc	-7541.5	7674
Acat1	-7712.5	7394
Isca2	-7257.5	7749
Sdhb	-7531.5	7210
Isca1	-7518.5	7203
Sdhd	-7560.5	7099
Nfs1	-7228.5	6950
Sirt3	-7200.5	6919
Iscu	-6425.5	6727
Sdhaf4	-5833.5	6482
Fxn	-6225.5	3804
Sdhaf3	-4898.5	4556
Aco2	-7213.5	2934
Sdhaf1	-4776.5	3263
Sdhaf2	-6848.5	538
Idh2	-7309.5	410

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acat1	-6035.5	-7712.5	7394
Aco2	3846.5	-7213.5	2934
Fxn	2418.5	-6225.5	3804
Idh2	-1028.5	-7309.5	410
Isca1	2229.5	-7518.5	7203
Isca2	3062.5	-7257.5	7749
Iscu	-3993.5	-6425.5	6727
Lyrm4	2645.5	2.5	7182
Nfs1	-2948.5	-7228.5	6950
Sdha	3963.5	-7707.5	7752
Sdhaf1	-828.5	-4776.5	3263
Sdhaf2	-3479.5	-6848.5	538
Sdhaf3	566.5	-4898.5	4556
Sdhaf4	-1357.5	-5833.5	6482
Sdhb	2919.5	-7531.5	7210
Sdhc	4079.5	-7541.5	7674
Sdhd	3291.5	-7560.5	7099
Sirt3	5215.5	-7200.5	6919

---

---

MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS

MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS

metric	value
setSize	10
pMANOVA	2.1e-05
p.adjustMANOVA	0.00018
s.dist	1.07
s.wt_gal3ko	0.166
s.wt_mst1ox	-0.73
s.mst1ox_mst1oxk	0.761
p.wt_gal3ko	0.365
p.wt_mst1ox	6.33e-05
p.mst1ox_mst1oxk	3.06e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Isca2	7749	-7257.5
Isca1	7203	-7518.5
Nfs1	6950	-7228.5
Iscu	6727	-6425.5
Fdx1	6090	-6717.5
Glrx5	6118	-4832.5
Fdxr	4844	-5162.5
Fxn	3804	-6225.5
Hscb	3248	-6041.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Fdx1	83.5	-6717.5	6090
Fdxr	2964.5	-5162.5	4844
Fxn	2418.5	-6225.5	3804
Glrx5	932.5	-4832.5	6118
Hscb	5957.5	-6041.5	3248
Isca1	2229.5	-7518.5	7203
Isca2	3062.5	-7257.5	7749
Iscu	-3993.5	-6425.5	6727
Lyrm4	2645.5	2.5	7182
Nfs1	-2948.5	-7228.5	6950

---

---

AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT

AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT

metric	value
setSize	202
pMANOVA	1.78e-101
p.adjustMANOVA	1.6e-98
s.dist	1.04
s.wt_gal3ko	0.176
s.wt_mst1ox	-0.786
s.mst1ox_mst1oxk	0.653
p.wt_gal3ko	1.65e-05
p.wt_mst1ox	3.09e-83
p.mst1ox_mst1oxk	8.16e-58

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Ndufab1	-7698.5	7795
Suclg1	-7732.5	7756
Cox7a1	-7777.5	7707
Cox5a	-7703.5	7763
Sdha	-7707.5	7752
Dlst	-7780.5	7607
Pm20d1	-7787.5	7594
Ndufa5	-7746.5	7598
Ndufv2	-7672.5	7671
Etfdh	-7786.5	7551
Got1	-7644.5	7659
Etfa	-7766.5	7536
Dlat	-7564.5	7734
Gpt	-7508.5	7783
Idh3a	-7727.5	7496
Sdhc	-7541.5	7674
Idh3b	-7678.5	7521
Hspa9	-7763.5	7433
Ndufs3	-7686.5	7485
L2hgdh	-7540.5	7572

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acad9	-5597.5	-7087.5	6468
Acat1	-6035.5	-7712.5	7394
Aco2	3846.5	-7213.5	2934
Adhfe1	7655.5	-7793.5	7104
Armc8	-2745.5	-4929.5	-2260
Cmc1	2153.5	-4408.5	2058
Coa3	997.5	-3139.5	6848
Coa5	-4039.5	-6192.5	7335
Coq10a	-3836.5	-7397.5	7308
Coq10b	-7241.5	-2572.5	-6920
Cox11	-2891.5	-6690.5	7179
Cox14	-1993.5	-5886.5	5188
Cox15	4284.5	-7202.5	3896
Cox16	5656.5	30.5	-1138
Cox17	-470.5	-4322.5	-2893
Cox18	700.5	-4414.5	5641
Cox19	-7216.5	6776.5	6395
Cox20	7001.5	-5404.5	5609
Cox4i1	4003.5	-7294.5	6927
Cox4i2	-1032.5	-5203.5	4474
Cox5a	2217.5	-7703.5	7763
Cox5b	5346.5	-7225.5	7063
Cox6a1	6639.5	-3949.5	5470
Cox6a2	6445.5	-6766.5	6971
Cox6b1	6311.5	-6861.5	6566
Cox6b2	-204.5	-5595.5	6234
Cox6c	7497.5	-7238.5	6748
Cox7a1	1712.5	-7777.5	7707
Cox7a2	6943.5	-6681.5	6780
Cox7a2l	-6219.5	-6879.5	6385
Cox7b	5727.5	-7157.5	5006
Cox7c	6517.5	-7135.5	6726
Cox8a	5767.5	-1185.5	2548
Cs	2593.5	-7694.5	7139
Cyc1	3210.5	-7255.5	6957
Cycs	3494.5	-7336.5	6637
D2hgdh	-893.5	-6956.5	6571
Dlat	-2899.5	-7564.5	7734
Dld	3637.5	-7624.5	3955
Dlst	-1944.5	-7780.5	7607
Ecsit	1659.5	-6589.5	6750
Etfa	235.5	-7766.5	7536
Etfb	1414.5	-7567.5	7388
Etfdh	-1532.5	-7786.5	7551
Fahd1	3702.5	-7642.5	7361
Fh1	2897.5	-7529.5	7090
Fxn	2418.5	-6225.5	3804
Gid4	2536.5	-7209.5	-3928
Gid8	-1477.5	-5117.5	6057
Glo1	-5923.5	-5785.5	3860
Got1	391.5	-7644.5	7659
Got2	4061.5	-6959.5	5656
Gpt	3393.5	-7508.5	7783
Gstz1	6665.5	-7264.5	6407
Hagh	134.5	-1200.5	6544
Hccs	4669.5	-6749.5	3299
Higd1a	-5762.5	-7160.5	5218
Higd2a	5434.5	-5562.5	2837
Hscb	5957.5	-6041.5	3248
Hspa9	-12.5	-7763.5	7433
Idh2	-1028.5	-7309.5	410
Idh3a	6168.5	-7727.5	7496
Idh3b	3780.5	-7678.5	7521
Idh3g	4301.5	-7349.5	6575
Isca1	2229.5	-7518.5	7203
Isca2	3062.5	-7257.5	7749
Iscu	-3993.5	-6425.5	6727
L2hgdh	-4070.5	-7540.5	7572
Ldha	3270.5	-4720.5	1144
Ldhal6b	5565.5	-1655.5	-4896
Ldhb	-439.5	-7702.5	7303
Lyrm2	328.5	-4015.5	4990
Lyrm4	2645.5	2.5	7182
Lyrm7	305.5	-6367.5	7272
Maea	-4650.5	-1825.5	4532
Mdh1	3724.5	-7342.5	7413
Mdh2	-58.5	-7289.5	5846
Me1	7.5	-7018.5	3143
Me2	-4662.5	4725.5	2132
Me3	-309.5	-7579.5	7465
Mkln1	3281.5	-4361.5	601
Mrps36	4641.5	-5338.5	5081
mt-Co1	3401.5	-7341.5	2990
mt-Cytb	4254.5	-7373.5	5778
mt-Nd1	3766.5	-7122.5	4753
mt-Nd2	4362.5	-7092.5	4128
mt-Nd4	6285.5	-7111.5	4527
mt-Nd5	4498.5	-7241.5	5023
mt-Nd6	3913.5	-7086.5	7753
Ndufa1	5462.5	-6839.5	6200
Ndufa10	-5319.5	-7685.5	6701
Ndufa11	2449.5	-6409.5	5296
Ndufa12	5960.5	-7375.5	7479
Ndufa13	5603.5	-7073.5	7147
Ndufa2	-645.5	-6183.5	4733
Ndufa3	6116.5	-7593.5	7391
Ndufa4	5691.5	-7281.5	7259
Ndufa5	6989.5	-7746.5	7598
Ndufa6	4761.5	-7318.5	7568
Ndufa7	6460.5	-6304.5	6533
Ndufa8	-3066.5	-7188.5	6448
Ndufa9	-33.5	-7782.5	7325
Ndufab1	6903.5	-7698.5	7795
Ndufaf1	-4232.5	-7486.5	4589
Ndufaf2	1580.5	-5313.5	4693
Ndufaf3	-3734.5	-5604.5	6988
Ndufaf4	3053.5	-7224.5	5800
Ndufaf5	5220.5	-6466.5	4473
Ndufaf6	-3002.5	-7110.5	5517
Ndufaf7	-1322.5	-6810.5	4809
Ndufb10	-6588.5	-7326.5	6806
Ndufb11	6547.5	-7286.5	7141
Ndufb2	-879.5	-7475.5	3010
Ndufb3	-6198.5	-6925.5	6767
Ndufb4	6699.5	-7406.5	5756
Ndufb5	4917.5	-7136.5	6842
Ndufb6	-2328.5	-7304.5	5799
Ndufb7	-6.5	-6145.5	4947
Ndufb8	3157.5	-7633.5	7300
Ndufb9	2503.5	-7407.5	7100
Ndufc1	4333.5	-7471.5	7364
Ndufc2	6036.5	-7249.5	7618
Ndufs1	1820.5	-7645.5	7271
Ndufs2	-2710.5	-7619.5	7313
Ndufs3	3544.5	-7686.5	7485
Ndufs4	1522.5	-7515.5	7323
Ndufs5	-6770.5	-7258.5	5100
Ndufs6	5133.5	-7679.5	7038
Ndufs7	1093.5	-6951.5	6749
Ndufs8	2746.5	-7417.5	6993
Ndufv1	-1526.5	-6933.5	5612
Ndufv2	6092.5	-7672.5	7671
Ndufv3	1321.5	-7479.5	7277
Nek1	-3162.5	-4082.5	-3818
Nfs1	-2948.5	-7228.5	6950
Nnt	6104.5	-7680.5	7212
Nubpl	-3830.5	-7043.5	4394
Ogdh	2118.5	-7608.5	4780
Pcx	-6408.5	-6534.5	6633
Pdha1	2537.5	-7382.5	5384
Pdhb	1452.5	-7319.5	6706
Pdhx	-3741.5	-7696.5	7400
Pdk1	1325.5	-6558.5	2799
Pdk2	3026.5	-7201.5	7080
Pdk3	7402.5	7005.5	-4035
Pdk4	7318.5	1859.5	5809
Pdp1	1520.5	-4680.5	-851
Pdp2	-3200.5	-7368.5	6738
Pdpr	-6510.5	-7613.5	7285
Pgam5	2323.5	-5698.5	5611
Pkm	-5709.5	-6577.5	976
Pm20d1	-3769.5	-7787.5	7594
Pyurf	6987.5	-7020.5	-3016
Ranbp9	4679.5	-6411.5	1636
Rmnd5a	-170.5	-5637.5	-284
Rmnd5b	5144.5	5434.5	3888
Rps27a	393.5	-996.5	888
Sco1	-6499.5	-6709.5	4955
Sco2	4606.5	-4574.5	2341
Sdha	3963.5	-7707.5	7752
Sdhaf1	-828.5	-4776.5	3263
Sdhaf2	-3479.5	-6848.5	538
Sdhaf3	566.5	-4898.5	4556
Sdhaf4	-1357.5	-5833.5	6482
Sdhb	2919.5	-7531.5	7210
Sdhc	4079.5	-7541.5	7674
Sdhd	3291.5	-7560.5	7099
Sirt3	5215.5	-7200.5	6919
Sirt4	1853.5	-5456.5	3782
Slc25a11	3051.5	-7635.5	7339
Slc25a12	-885.5	-7434.5	6617
Slc25a13	-5672.5	-6901.5	2617
Slc25a14	-3753.5	3182.5	537
Slc25a22	4124.5	-6352.5	5634
Slc25a27	5731.5	1755.5	-2488
Slc25a4	3232.5	-7374.5	6841
Smim20	4794.5	-6760.5	6396
Sucla2	-7502.5	-7638.5	-1120
Suclg1	763.5	-7732.5	7756
Suclg2	-47.5	-7708.5	5754
Surf1	-4188.5	-6162.5	2712
Timm21	3881.5	-7163.5	4021
Timmdc1	-4646.5	-5878.5	7284
Tmem126b	-2314.5	-7010.5	3220
Tmem177	6019.5	-7334.5	6754
Tmem186	-3589.5	-7569.5	4437
Trap1	-629.5	-7141.5	3221
Ttc19	-3230.5	-7345.5	4223
Uba52	2997.5	-3735.5	-311
Ubb	-214.5	-1647.5	-3950
Ubc	7553.5	-2084.5	4118
Ucp2	-4410.5	3317.5	-4573
Ucp3	3976.5	-5134.5	4604
Uqcr10	5053.5	-4460.5	5424
Uqcrb	6093.5	-7102.5	6620
Uqcrc1	917.5	-7436.5	6703
Uqcrc2	3455.5	-7665.5	7441
Uqcrfs1	1348.5	-7690.5	7145
Uqcrh	3517.5	-6804.5	7305
Uqcrq	6492.5	-7130.5	6935
Vdac1	2205.5	-7461.5	6640
Wdr26	5364.5	652.5	-3159

---

---

MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION

metric	value
setSize	87
pMANOVA	7.76e-43
p.adjustMANOVA	1.75e-40
s.dist	1.03
s.wt_gal3ko	0.0383
s.wt_mst1ox	-0.777
s.mst1ox_mst1oxk	0.67
p.wt_gal3ko	0.537
p.wt_mst1ox	3.76e-36
p.mst1ox_mst1oxk	2.88e-27

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Mrpl45	-7675.5	7466
Mrpl39	-7388.5	7546
Gfm2	-7528.5	7392
Mrpl30	-7395.5	7262
Mrpl46	-7502.5	7128
Mrps35	-7643.5	6907
Mrpl21	-7420.5	7102
Mrpl41	-7001.5	7492
Mrpl42	-7617.5	6857
Dap3	-7162.5	7287
Oxa1l	-6826.5	7627
Mrps27	-7362.5	6922
Mrpl51	-7305.5	6906
Mrpl35	-7245.5	6914
Mrps15	-7230.5	6779
Mrpl19	-7187.5	6718
Mrpl12	-6700.5	7089
Gfm1	-7582.5	6201
Mrps2	-7544.5	6179
Mrpl15	-7070.5	6530

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Aurkaip1	4825.5	-6058.5	6525
Chchd1	3487.5	-5905.5	7336
Dap3	-5314.5	-7162.5	7287
Eral1	2528.5	-6936.5	5892
Gadd45gip1	2440.5	-6772.5	5795
Gfm1	-2212.5	-7582.5	6201
Gfm2	-5324.5	-7528.5	7392
Mrpl1	2174.5	-7115.5	3297
Mrpl10	-2981.5	-6287.5	3780
Mrpl11	-4374.5	-6369.5	6691
Mrpl12	494.5	-6700.5	7089
Mrpl13	-2184.5	-6926.5	5160
Mrpl14	-585.5	-6873.5	6562
Mrpl15	725.5	-7070.5	6530
Mrpl16	-3560.5	-6921.5	2831
Mrpl17	1170.5	-4847.5	5581
Mrpl18	1798.5	-7154.5	6196
Mrpl19	1151.5	-7187.5	6718
Mrpl2	2595.5	-6105.5	5262
Mrpl20	5533.5	-4235.5	6164
Mrpl21	-4399.5	-7420.5	7102
Mrpl22	1084.5	-6499.5	3803
Mrpl23	7392.5	-4007.5	2622
Mrpl24	-4837.5	-4518.5	4636
Mrpl27	-4693.5	-5327.5	5899
Mrpl28	-7415.5	-7405.5	5123
Mrpl3	-1727.5	-7054.5	5561
Mrpl30	1881.5	-7395.5	7262
Mrpl32	3017.5	-5953.5	-5017
Mrpl33	7219.5	3611.5	6931
Mrpl34	-3484.5	-6661.5	6261
Mrpl35	-1481.5	-7245.5	6914
Mrpl36	-707.5	-5185.5	6522
Mrpl37	541.5	-7337.5	6187
Mrpl38	3359.5	-6204.5	5404
Mrpl39	7251.5	-7388.5	7546
Mrpl4	103.5	-6653.5	5727
Mrpl40	-5011.5	-4911.5	5183
Mrpl41	-2963.5	-7001.5	7492
Mrpl42	6274.5	-7617.5	6857
Mrpl43	-3854.5	-5641.5	6616
Mrpl44	-3032.5	-7053.5	6442
Mrpl45	-5830.5	-7675.5	7466
Mrpl46	-6128.5	-7502.5	7128
Mrpl47	2547.5	-7184.5	6142
Mrpl48	6169.5	-1441.5	6035
Mrpl49	-6235.5	-6232.5	6066
Mrpl50	412.5	-6997.5	373
Mrpl51	971.5	-7305.5	6906
Mrpl52	2724.5	554.5	6071
Mrpl54	4519.5	-2632.5	5316
Mrpl55	5504.5	-6818.5	6206
Mrpl57	4628.5	-3823.5	4943
Mrpl9	-5145.5	-7465.5	3630
Mrps10	4348.5	2607.5	7078
Mrps11	-6060.5	-5880.5	115
Mrps12	-5162.5	-4282.5	6190
Mrps14	-3506.5	-6676.5	6766
Mrps15	5610.5	-7230.5	6779
Mrps16	-4338.5	-6420.5	5528
Mrps17	-3339.5	-6999.5	4119
Mrps18a	-3821.5	-6780.5	5334
Mrps18b	5679.5	-4853.5	6186
Mrps18c	-2152.5	-6052.5	1111
Mrps2	4337.5	-7544.5	6179
Mrps21	683.5	-7047.5	6177
Mrps22	5709.5	-6779.5	2148
Mrps23	-5222.5	-5908.5	5839
Mrps24	4279.5	-6091.5	5934
Mrps25	-5206.5	-7085.5	4107
Mrps26	489.5	-3319.5	5000
Mrps27	1447.5	-7362.5	6922
Mrps28	5744.5	-6892.5	6332
Mrps30	6615.5	-6979.5	4024
Mrps31	5255.5	-7553.5	4919
Mrps33	-1056.5	-5975.5	3898
Mrps34	-6207.5	-5004.5	6170
Mrps35	6867.5	-7643.5	6907
Mrps36	4641.5	-5338.5	5081
Mrps5	7495.5	-7078.5	4980
Mrps6	3276.5	-2730.5	-5238
Mrps7	-3023.5	-6800.5	4702
Mrps9	-3510.5	-7710.5	4801
Mrrf	3.5	-7096.5	3745
Mtrf1l	7447.5	-5971.5	723
Oxa1l	7508.5	-6826.5	7627
Ptcd3	-4140.5	-7489.5	2875

---

---

CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS

metric	value
setSize	18
pMANOVA	6.68e-09
p.adjustMANOVA	1.16e-07
s.dist	1.03
s.wt_gal3ko	-0.34
s.wt_mst1ox	0.692
s.mst1ox_mst1oxk	-0.676
p.wt_gal3ko	0.0125
p.wt_mst1ox	3.64e-07
p.mst1ox_mst1oxk	6.88e-07

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col4a3	7307.5	-7227
Loxl2	7079.5	-7363
Col4a4	7256.5	-7015
Col1a2	7112.5	-6884
Loxl3	7086.5	-6495
Loxl4	6099.5	-7054
Lox	6388.5	-6132
Col1a1	6801.5	-5269
Col4a5	7299.5	-4615
Col4a1	5401.5	-6011
Pcolce	6881.5	-4622
Col4a2	4843.5	-6504
Tll1	5176.5	-4233
Bmp1	6565.5	-2394
Loxl1	6192.5	-1109

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Bmp1	-833.5	6565.5	-2394
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Lox	-1869.5	6388.5	-6132
Loxl1	-7029.5	6192.5	-1109
Loxl2	-153.5	7079.5	-7363
Loxl3	-2393.5	7086.5	-6495
Loxl4	30.5	6099.5	-7054
Pcolce	-3839.5	6881.5	-4622
Pxdn	5676.5	-5990.5	-7124
Tll1	2246.5	5176.5	-4233
Tll2	-6088.5	-4614.5	-6099

---

---

MITOCHONDRIAL PROTEIN DEGRADATION

MITOCHONDRIAL PROTEIN DEGRADATION

metric	value
setSize	70
pMANOVA	5.27e-32
p.adjustMANOVA	5.27e-30
s.dist	0.989
s.wt_gal3ko	0.0661
s.wt_mst1ox	-0.761
s.mst1ox_mst1oxk	0.628
p.wt_gal3ko	0.339
p.wt_mst1ox	2.72e-28
p.mst1ox_mst1oxk	9.87e-20

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Cox5a	-7703.5	7763
Ldhd	-7701.5	7663
Nadk2	-7715.5	7603
Idh3a	-7727.5	7496
Acot1	-7501.5	7716
Ech1	-7535.5	7680
Hspa9	-7763.5	7433
Ndufs3	-7686.5	7485
Hadh	-7789.5	7375
Eci1	-7725.5	7431
Uqcrc2	-7665.5	7441
Acat1	-7712.5	7394
Ndufs1	-7645.5	7271
Hsd17b10	-7548.5	7282
Cs	-7694.5	7139
Dbt	-7745.5	7077
Ndufv3	-7479.5	7277
Fh1	-7529.5	7090
Acot2	-7351.5	7256
Pmpca	-7323.5	7246

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acad8	-7066.5	-7270.5	1682
Acadsb	4777.5	-7324.5	5315
Acat1	-6035.5	-7712.5	7394
Aco2	3846.5	-7213.5	2934
Acot1	6765.5	-7501.5	7716
Acot2	-2155.5	-7351.5	7256
Acot3	3092.5	-6542.5	1109
Afg3l2	-7000.5	-7325.5	5595
Alas1	756.5	-6948.5	6538
Aldh18a1	-7291.5	4077.5	-2734
Aldh1b1	3237.5	-4786.5	4574
Aldh2	-400.5	-5608.5	5602
App	-3352.5	6935.5	-4058
Bdh1	-3657.5	-1278.5	6064
Clpp	6476.5	-7205.5	4142
Clpx	2544.5	-7519.5	5199
Cox5a	2217.5	-7703.5	7763
Cox5b	5346.5	-7225.5	7063
Cs	2593.5	-7694.5	7139
Dbt	1472.5	-7745.5	7077
Dld	3637.5	-7624.5	3955
Ech1	3983.5	-7535.5	7680
Eci1	3926.5	-7725.5	7431
Fech	-3483.5	-7592.5	6513
Fh1	2897.5	-7529.5	7090
Glud1	-7425.5	-7423.5	-1262
Hadh	-934.5	-7789.5	7375
Hmgcs2	-419.5	-6408.5	7389
Hsd17b10	5639.5	-7548.5	7282
Hspa9	-12.5	-7763.5	7433
Hspd1	3156.5	-7621.5	5441
Htra2	3968.5	-4802.5	-717
Iars2	-5974.5	-7456.5	6405
Idh2	-1028.5	-7309.5	410
Idh3a	6168.5	-7727.5	7496
Ldhd	-7476.5	-7701.5	7663
Lonp1	-4373.5	-4109.5	5870
Mdh2	-58.5	-7289.5	5846
Me2	-4662.5	4725.5	2132
Mrpl12	494.5	-6700.5	7089
Mrpl32	3017.5	-5953.5	-5017
Mrps10	4348.5	2607.5	7078
Mrps2	4337.5	-7544.5	6179
mt-Co1	3401.5	-7341.5	2990
Nadk2	911.5	-7715.5	7603
Ndufa13	5603.5	-7073.5	7147
Ndufa2	-645.5	-6183.5	4733
Ndufs1	1820.5	-7645.5	7271
Ndufs3	3544.5	-7686.5	7485
Ndufv1	-1526.5	-6933.5	5612
Ndufv3	1321.5	-7479.5	7277
Ogdh	2118.5	-7608.5	4780
Oxct1	-578.5	-7521.5	6878
Oxsm	-4080.5	-6764.5	2293
Pccb	-4333.5	-7517.5	2577
Pdha1	2537.5	-7382.5	5384
Pdhb	1452.5	-7319.5	6706
Pdk1	1325.5	-6558.5	2799
Pmpca	-3389.5	-7323.5	7246
Prkaca	1203.5	-6357.5	6034
Shmt2	4047.5	-6208.5	4300
Slc25a5	-2306.5	-4654.5	5327
Smdt1	-4649.5	127.5	5645
Spg7	-3268.5	-6158.5	3801
Ssbp1	4411.5	-2721.5	-3049
Star	6398.5	7439.5	186
Suclg2	-47.5	-7708.5	5754
Tfam	-796.5	-6934.5	5741
Uqcrc2	3455.5	-7665.5	7441
Uqcrq	6492.5	-7130.5	6935

---

---

BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS

BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS

metric	value
setSize	11
pMANOVA	5.66e-05
p.adjustMANOVA	0.000392
s.dist	0.97
s.wt_gal3ko	0.0169
s.wt_mst1ox	-0.67
s.mst1ox_mst1oxk	0.701
p.wt_gal3ko	0.922
p.wt_mst1ox	0.000118
p.mst1ox_mst1oxk	5.73e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Hsd17b4	7386	-7458.5
Mlycd	7253	-6985.5
Acox1	6296	-7669.5
Eci2	5688	-7657.5
Abcd1	6524	-6415.5
Acot4	6979	-5724.5
Decr2	6052	-5240.5
Acot6	5103	-3310.5
Ehhadh	2218	-6680.5
Acaa1b	5040	-373.5
Acot8	2283	-597.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Abcd1	4494.5	-6415.5	6524
Acaa1b	1513.5	-373.5	5040
Acot4	-4166.5	-5724.5	6979
Acot6	1422.5	-3310.5	5103
Acot8	-3204.5	-597.5	2283
Acox1	-7466.5	-7669.5	6296
Decr2	4521.5	-5240.5	6052
Eci2	1790.5	-7657.5	5688
Ehhadh	6658.5	-6680.5	2218
Hsd17b4	-5866.5	-7458.5	7386
Mlycd	2542.5	-6985.5	7253

---

---

COMPLEX IV ASSEMBLY

COMPLEX IV ASSEMBLY

metric	value
setSize	38
pMANOVA	1.8e-16
p.adjustMANOVA	7.72e-15
s.dist	0.966
s.wt_gal3ko	0.226
s.wt_mst1ox	-0.709
s.mst1ox_mst1oxk	0.616
p.wt_gal3ko	0.0159
p.wt_mst1ox	3.85e-14
p.mst1ox_mst1oxk	4.88e-11

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Cox7a1	-7777.5	7707
Cox5a	-7703.5	7763
Coq10a	-7397.5	7308
Ndufa4	-7281.5	7259
Cox5b	-7225.5	7063
Cox4i1	-7294.5	6927
Tmem177	-7334.5	6754
Cox6c	-7238.5	6748
Cox11	-6690.5	7179
Cox7c	-7135.5	6726
Cox6a2	-6766.5	6971
Coa5	-6192.5	7335
Cox7a2	-6681.5	6780
Cox6b1	-6861.5	6566
Cox7a2l	-6879.5	6385
Smim20	-6760.5	6396
Higd1a	-7160.5	5218
Cox7b	-7157.5	5006
Cox6b2	-5595.5	6234
Sco1	-6709.5	4955

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Cmc1	2153.5	-4408.5	2058
Coa3	997.5	-3139.5	6848
Coa5	-4039.5	-6192.5	7335
Coq10a	-3836.5	-7397.5	7308
Coq10b	-7241.5	-2572.5	-6920
Cox11	-2891.5	-6690.5	7179
Cox14	-1993.5	-5886.5	5188
Cox15	4284.5	-7202.5	3896
Cox16	5656.5	30.5	-1138
Cox17	-470.5	-4322.5	-2893
Cox18	700.5	-4414.5	5641
Cox19	-7216.5	6776.5	6395
Cox20	7001.5	-5404.5	5609
Cox4i1	4003.5	-7294.5	6927
Cox4i2	-1032.5	-5203.5	4474
Cox5a	2217.5	-7703.5	7763
Cox5b	5346.5	-7225.5	7063
Cox6a1	6639.5	-3949.5	5470
Cox6a2	6445.5	-6766.5	6971
Cox6b1	6311.5	-6861.5	6566
Cox6b2	-204.5	-5595.5	6234
Cox6c	7497.5	-7238.5	6748
Cox7a1	1712.5	-7777.5	7707
Cox7a2	6943.5	-6681.5	6780
Cox7a2l	-6219.5	-6879.5	6385
Cox7b	5727.5	-7157.5	5006
Cox7c	6517.5	-7135.5	6726
Cox8a	5767.5	-1185.5	2548
Higd1a	-5762.5	-7160.5	5218
Higd2a	5434.5	-5562.5	2837
mt-Co1	3401.5	-7341.5	2990
Ndufa4	5691.5	-7281.5	7259
Sco1	-6499.5	-6709.5	4955
Sco2	4606.5	-4574.5	2341
Smim20	4794.5	-6760.5	6396
Surf1	-4188.5	-6162.5	2712
Timm21	3881.5	-7163.5	4021
Tmem177	6019.5	-7334.5	6754

---

---

COLLAGEN CHAIN TRIMERIZATION

COLLAGEN CHAIN TRIMERIZATION

metric	value
setSize	34
pMANOVA	9.66e-15
p.adjustMANOVA	3.34e-13
s.dist	0.936
s.wt_gal3ko	-0.34
s.wt_mst1ox	0.733
s.mst1ox_mst1oxk	-0.472
p.wt_gal3ko	0.000605
p.wt_mst1ox	1.31e-13
p.mst1ox_mst1oxk	1.93e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col12a1	7358.5	-7275
Col11a1	7324.5	-7259
Col4a3	7307.5	-7227
Col5a2	7277.5	-7209
Col8a2	7341.5	-7100
Col14a1	7029.5	-7413
Col8a1	7060.5	-7349
Col4a4	7256.5	-7015
Col22a1	7259.5	-6901
Col6a1	6887.5	-7170
Col1a2	7112.5	-6884
Col16a1	7242.5	-6756
Col6a2	6990.5	-6620
Col3a1	6825.5	-6768
Col13a1	5244.5	-6927
Col1a1	6801.5	-5269
Col4a5	7299.5	-4615
Col4a1	5401.5	-6011
Col5a1	6613.5	-4764
Col4a2	4843.5	-6504

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Col11a1	4153.5	7324.5	-7259
Col11a2	4930.5	3368.5	-3186
Col12a1	2711.5	7358.5	-7275
Col13a1	5587.5	5244.5	-6927
Col14a1	-6132.5	7029.5	-7413
Col15a1	-6535.5	7067.5	-3977
Col16a1	-3835.5	7242.5	-6756
Col18a1	-6067.5	5446.5	4992
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col20a1	110.5	6720.5	7524
Col22a1	-4905.5	7259.5	-6901
Col23a1	-6602.5	908.5	-3080
Col25a1	-1661.5	-1726.5	-3781
Col26a1	-6596.5	5088.5	-5287
Col28a1	4846.5	3652.5	-3687
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col7a1	4161.5	6902.5	5428
Col8a1	-7150.5	7060.5	-7349
Col8a2	4475.5	7341.5	-7100
Col9a2	-2728.5	6879.5	4161

---

---

HEME BIOSYNTHESIS

HEME BIOSYNTHESIS

metric	value
setSize	12
pMANOVA	4.81e-05
p.adjustMANOVA	0.000355
s.dist	0.929
s.wt_gal3ko	-0.0591
s.wt_mst1ox	-0.682
s.mst1ox_mst1oxk	0.629
p.wt_gal3ko	0.723
p.wt_mst1ox	4.34e-05
p.mst1ox_mst1oxk	0.000161

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Alad	-7277.5	6975
Fech	-7592.5	6513
Uros	-6771.5	7105
Alas1	-6948.5	6538
Hmbs	-6783.5	5571
Cox10	-7440.5	5005
Cox15	-7202.5	3896
Urod	-6640.5	4149
Cpox	-6353.5	3062
Ppox	-1183.5	5071

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Alad	-7238.5	-7277.5	6975
Alas1	756.5	-6948.5	6538
Alas2	5702.5	-1531.5	-233
Alb	-390.5	1313.5	6153
Cox10	2517.5	-7440.5	5005
Cox15	4284.5	-7202.5	3896
Cpox	-7082.5	-6353.5	3062
Fech	-3483.5	-7592.5	6513
Hmbs	-6120.5	-6783.5	5571
Ppox	2690.5	-1183.5	5071
Urod	3778.5	-6640.5	4149
Uros	75.5	-6771.5	7105

---

---

NCAM1 INTERACTIONS

NCAM1 INTERACTIONS

metric	value
setSize	16
pMANOVA	6.12e-07
p.adjustMANOVA	7.98e-06
s.dist	0.922
s.wt_gal3ko	-0.501
s.wt_mst1ox	0.619
s.mst1ox_mst1oxk	-0.465
p.wt_gal3ko	0.000523
p.wt_mst1ox	1.8e-05
p.mst1ox_mst1oxk	0.00128

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	wt_gal3ko
Col4a4	7256.5	-7068.5
Col4a3	7307.5	-6741.5
Col6a3	6398.5	-7051.5
Col3a1	6825.5	-6278.5
Col6a1	6887.5	-5925.5
Col6a2	6990.5	-4973.5
Col4a1	5401.5	-6405.5
Col4a2	4843.5	-6463.5
Col5a1	6613.5	-4525.5
Col5a2	7277.5	-3971.5
St8sia2	5280.5	-4886.5
Col9a2	6879.5	-2728.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col9a2	-2728.5	6879.5	4161
St8sia2	-4886.5	5280.5	-2395
St8sia4	3253.5	-4284.5	-2913

---

---

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX

metric	value
setSize	14
pMANOVA	1.2e-05
p.adjustMANOVA	0.000111
s.dist	0.921
s.wt_gal3ko	0.181
s.wt_mst1ox	-0.679
s.mst1ox_mst1oxk	0.596
p.wt_gal3ko	0.24
p.wt_mst1ox	1.08e-05
p.mst1ox_mst1oxk	0.000114

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Dlat	-7564.5	7734
Pdhx	-7696.5	7400
Pdpr	-7613.5	7285
Pdk2	-7201.5	7080
Pdp2	-7368.5	6738
Pdhb	-7319.5	6706
Gstz1	-7264.5	6407
Pdha1	-7382.5	5384
Dld	-7624.5	3955
Sirt4	-5456.5	3782
Pdk1	-6558.5	2799

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Dlat	-2899.5	-7564.5	7734
Dld	3637.5	-7624.5	3955
Gstz1	6665.5	-7264.5	6407
Pdha1	2537.5	-7382.5	5384
Pdhb	1452.5	-7319.5	6706
Pdhx	-3741.5	-7696.5	7400
Pdk1	1325.5	-6558.5	2799
Pdk2	3026.5	-7201.5	7080
Pdk3	7402.5	7005.5	-4035
Pdk4	7318.5	1859.5	5809
Pdp1	1520.5	-4680.5	-851
Pdp2	-3200.5	-7368.5	6738
Pdpr	-6510.5	-7613.5	7285
Sirt4	1853.5	-5456.5	3782

---

---

NON INTEGRIN MEMBRANE ECM INTERACTIONS

NON INTEGRIN MEMBRANE ECM INTERACTIONS

metric	value
setSize	30
pMANOVA	4.35e-11
p.adjustMANOVA	1.03e-09
s.dist	0.881
s.wt_gal3ko	-0.343
s.wt_mst1ox	0.612
s.mst1ox_mst1oxk	-0.534
p.wt_gal3ko	0.00116
p.wt_mst1ox	6.5e-09
p.mst1ox_mst1oxk	4.18e-07

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col11a1	7324.5	-7259
Col4a3	7307.5	-7227
Col5a2	7277.5	-7209
Col4a4	7256.5	-7015
Col1a2	7112.5	-6884
Fn1	6674.5	-7089
Col3a1	6825.5	-6768
Sdc2	7146.5	-5683
Ddr2	5501.5	-6685
Col1a1	6801.5	-5269
Itga2	6287.5	-5668
Col4a5	7299.5	-4615
Col4a1	5401.5	-6011
Col5a1	6613.5	-4764
Col4a2	4843.5	-6504
Sdc3	4180.5	-7141
Itgb1	6225.5	-4513
Itgav	7044.5	-2619
Ddr1	6633.5	-2458
Sdc1	5343.5	-2888

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Col11a1	4153.5	7324.5	-7259
Col11a2	4930.5	3368.5	-3186
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Ddr1	-449.5	6633.5	-2458
Ddr2	-5781.5	5501.5	-6685
Fgf2	-75.5	-4844.5	-5254
Fn1	-4709.5	6674.5	-7089
Itga2	6056.5	6287.5	-5668
Itga6	-3992.5	-2635.5	-6569
Itgav	-5394.5	7044.5	-2619
Itgb1	-1133.5	6225.5	-4513
Itgb3	1460.5	4215.5	-1052
Itgb4	264.5	3931.5	-1988
Sdc1	-4854.5	5343.5	-2888
Sdc2	-1162.5	7146.5	-5683
Sdc3	-5505.5	4180.5	-7141
Sdc4	-7387.5	106.5	-3077
Tgfb1	-683.5	5780.5	-1753
Vtn	-4954.5	-7215.5	7193

---

---

MITOCHONDRIAL BIOGENESIS

MITOCHONDRIAL BIOGENESIS

metric	value
setSize	10
pMANOVA	0.000526
p.adjustMANOVA	0.0025
s.dist	0.879
s.wt_gal3ko	0.141
s.wt_mst1ox	-0.738
s.mst1ox_mst1oxk	0.456
p.wt_gal3ko	0.439
p.wt_mst1ox	5.36e-05
p.mst1ox_mst1oxk	0.0125

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Sod2	-7794.5	7639
Sirt5	-7460.5	6985
Sirt3	-7200.5	6919
Cycs	-7336.5	6637
Sirt4	-5456.5	3782
Acss2	-686.5	7739
Idh2	-7309.5	410
Gabpa	-5968.5	31

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acss2	1243.5	-686.5	7739
Cycs	3494.5	-7336.5	6637
Gabpa	6620.5	-5968.5	31
Gabpb1	3956.5	-1311.5	-2221
Glud1	-7425.5	-7423.5	-1262
Idh2	-1028.5	-7309.5	410
Sirt3	5215.5	-7200.5	6919
Sirt4	1853.5	-5456.5	3782
Sirt5	-3452.5	-7460.5	6985
Sod2	1031.5	-7794.5	7639

---

---

TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS

TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS

metric	value
setSize	10
pMANOVA	0.000526
p.adjustMANOVA	0.0025
s.dist	0.879
s.wt_gal3ko	0.141
s.wt_mst1ox	-0.738
s.mst1ox_mst1oxk	0.456
p.wt_gal3ko	0.439
p.wt_mst1ox	5.36e-05
p.mst1ox_mst1oxk	0.0125

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Sod2	-7794.5	7639
Sirt5	-7460.5	6985
Sirt3	-7200.5	6919
Cycs	-7336.5	6637
Sirt4	-5456.5	3782
Acss2	-686.5	7739
Idh2	-7309.5	410
Gabpa	-5968.5	31

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acss2	1243.5	-686.5	7739
Cycs	3494.5	-7336.5	6637
Gabpa	6620.5	-5968.5	31
Gabpb1	3956.5	-1311.5	-2221
Glud1	-7425.5	-7423.5	-1262
Idh2	-1028.5	-7309.5	410
Sirt3	5215.5	-7200.5	6919
Sirt4	1853.5	-5456.5	3782
Sirt5	-3452.5	-7460.5	6985
Sod2	1031.5	-7794.5	7639

---

---

GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION

GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION

metric	value
setSize	14
pMANOVA	3.41e-05
p.adjustMANOVA	0.000265
s.dist	0.874
s.wt_gal3ko	0.003
s.wt_mst1ox	-0.555
s.mst1ox_mst1oxk	0.675
p.wt_gal3ko	0.984
p.wt_mst1ox	0.000327
p.mst1ox_mst1oxk	1.21e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Dlst	7607	-7780.5
Aldh4a1	7625	-7586.5
Got2	5656	-6959.5
Ogdh	4780	-7608.5
Ddo	6984	-5188.5
Gnmt	7214	-4732.5
Gcsh	6168	-5471.5
Dld	3955	-7624.5
Mrps36	5081	-5338.5
Amt	4235	-2126.5
Grhpr	757	-5791.5
Dao	5894	-109.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Aldh4a1	-6519.5	-7586.5	7625
Amt	-3088.5	-2126.5	4235
Dao	-334.5	-109.5	5894
Ddo	5791.5	-5188.5	6984
Dld	3637.5	-7624.5	3955
Dlst	-1944.5	-7780.5	7607
Gcsh	-6962.5	-5471.5	6168
Gldc	-1129.5	2230.5	3637
Gnmt	1713.5	-4732.5	7214
Got2	4061.5	-6959.5	5656
Grhpr	-7417.5	-5791.5	757
Hoga1	6795.5	2483.5	5099
Mrps36	4641.5	-5338.5	5081
Ogdh	2118.5	-7608.5	4780

---

---

MET ACTIVATES PTK2 SIGNALING

MET ACTIVATES PTK2 SIGNALING

metric	value
setSize	18
pMANOVA	2e-06
p.adjustMANOVA	2.28e-05
s.dist	0.855
s.wt_gal3ko	-0.192
s.wt_mst1ox	0.681
s.mst1ox_mst1oxk	-0.481
p.wt_gal3ko	0.159
p.wt_mst1ox	5.66e-07
p.mst1ox_mst1oxk	0.000414

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col11a1	7324.5	-7259
Col5a2	7277.5	-7209
Col1a2	7112.5	-6884
Fn1	6674.5	-7089
Col3a1	6825.5	-6768
Col1a1	6801.5	-5269
Itga2	6287.5	-5668
Col5a1	6613.5	-4764
Itgb1	6225.5	-4513
Lama4	3800.5	-4820
Col11a2	3368.5	-3186
Megf6	2608.5	-4053
Hgf	2062.5	-2820
Itga3	5607.5	-911

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Col11a1	4153.5	7324.5	-7259
Col11a2	4930.5	3368.5	-3186
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col3a1	-6278.5	6825.5	-6768
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Fn1	-4709.5	6674.5	-7089
Hgf	3964.5	2062.5	-2820
Itga2	6056.5	6287.5	-5668
Itga3	-4147.5	5607.5	-911
Itgb1	-1133.5	6225.5	-4513
Lama4	-1771.5	3800.5	-4820
Megf6	-5354.5	2608.5	-4053
Met	-3101.5	6971.5	5923
Ptk2	1062.5	-391.5	-6120
Src	1121.5	7217.5	2088

---

---

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES

metric	value
setSize	53
pMANOVA	1.82e-18
p.adjustMANOVA	1.09e-16
s.dist	0.85
s.wt_gal3ko	-0.272
s.wt_mst1ox	0.659
s.mst1ox_mst1oxk	-0.462
p.wt_gal3ko	0.000611
p.wt_mst1ox	9.9e-17
p.mst1ox_mst1oxk	6.11e-09

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col12a1	7358.5	-7275
Col11a1	7324.5	-7259
Col4a3	7307.5	-7227
Col5a2	7277.5	-7209
Col8a2	7341.5	-7100
Col14a1	7029.5	-7413
Col8a1	7060.5	-7349
Col4a4	7256.5	-7015
Col22a1	7259.5	-6901
Adamts2	6841.5	-7232
Col6a1	6887.5	-7170
Col1a2	7112.5	-6884
Col16a1	7242.5	-6756
Col6a2	6990.5	-6620
Col3a1	6825.5	-6768
Plod2	6408.5	-7120
Pcolce2	7041.5	-6375
Col13a1	5244.5	-6927
Col1a1	6801.5	-5269
P3h3	6865.5	-5069

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Adamts14	-102.5	5846.5	2129
Adamts2	-4279.5	6841.5	-7232
Adamts3	5490.5	-4018.5	-7310
Bmp1	-833.5	6565.5	-2394
Col11a1	4153.5	7324.5	-7259
Col11a2	4930.5	3368.5	-3186
Col12a1	2711.5	7358.5	-7275
Col13a1	5587.5	5244.5	-6927
Col14a1	-6132.5	7029.5	-7413
Col15a1	-6535.5	7067.5	-3977
Col16a1	-3835.5	7242.5	-6756
Col18a1	-6067.5	5446.5	4992
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col20a1	110.5	6720.5	7524
Col22a1	-4905.5	7259.5	-6901
Col23a1	-6602.5	908.5	-3080
Col25a1	-1661.5	-1726.5	-3781
Col26a1	-6596.5	5088.5	-5287
Col28a1	4846.5	3652.5	-3687
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col7a1	4161.5	6902.5	5428
Col8a1	-7150.5	7060.5	-7349
Col8a2	4475.5	7341.5	-7100
Col9a2	-2728.5	6879.5	4161
Colgalt1	-3011.5	3585.5	-2325
Colgalt2	-2515.5	-1962.5	-4249
P3h2	-3515.5	7439.5	7124
P3h3	-3743.5	6865.5	-5069
P4ha1	-1889.5	6829.5	-3830
P4ha2	-7450.5	-3947.5	-2123
P4hb	-4929.5	5325.5	-4687
Pcolce	-3839.5	6881.5	-4622
Pcolce2	7097.5	7041.5	-6375
Plod1	2492.5	2663.5	-3359
Plod2	7007.5	6408.5	-7120
Plod3	-7202.5	5321.5	2737
Serpinh1	4796.5	4119.5	-1160
Tll1	2246.5	5176.5	-4233
Tll2	-6088.5	-4614.5	-6099

---

---

ER PHAGOSOME PATHWAY

ER PHAGOSOME PATHWAY

metric	value
setSize	19
pMANOVA	4.73e-07
p.adjustMANOVA	6.55e-06
s.dist	0.835
s.wt_gal3ko	-0.518
s.wt_mst1ox	0.341
s.mst1ox_mst1oxk	-0.56
p.wt_gal3ko	9.27e-05
p.wt_mst1ox	0.0101
p.mst1ox_mst1oxk	2.38e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_gal3ko
H2-T22	-7408	-7126.5
H2-T23	-7168	-7213.5
H2-Q4	-7396	-6576.5
H2-K1	-7407	-6356.5
H2-Q6	-7424	-6315.5
B2m	-7409	-5962.5
H2-Q7	-7417	-5203.5
Vamp3	-5880	-6160.5
H2-M3	-6202	-5646.5
Tap2	-4668	-6388.5
Tapbp	-3404	-5917.5
Tap1	-7282	-2689.5
H2-T10	-5883	-2083.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
B2m	-5962.5	4814.5	-7409
Calr	-1710.5	-5146.5	3306
H2-K1	-6356.5	4150.5	-7407
H2-M3	-5646.5	1899.5	-6202
H2-Q4	-6576.5	2988.5	-7396
H2-Q6	-6315.5	3177.5	-7424
H2-Q7	-5203.5	3208.5	-7417
H2-T10	-2083.5	3758.5	-5883
H2-T22	-7126.5	5423.5	-7408
H2-T23	-7213.5	6309.5	-7168
Pdia3	1124.5	1239.5	-3591
Sec22b	-4524.5	4088.5	535
Snap23	129.5	-2628.5	-2465
Stx4a	4550.5	3832.5	3961
Tap1	-2689.5	5074.5	-7282
Tap2	-6388.5	-2508.5	-4668
Tapbp	-5917.5	3092.5	-3404
Vamp3	-6160.5	-305.5	-5880
Vamp8	560.5	3465.5	5864

---

---

ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES

ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES

metric	value
setSize	42
pMANOVA	3.37e-14
p.adjustMANOVA	1.12e-12
s.dist	0.831
s.wt_gal3ko	-0.366
s.wt_mst1ox	0.602
s.mst1ox_mst1oxk	-0.44
p.wt_gal3ko	4.11e-05
p.wt_mst1ox	1.45e-11
p.mst1ox_mst1oxk	8.07e-07

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col12a1	7358.5	-7275
Col11a1	7324.5	-7259
Col4a3	7307.5	-7227
Col5a2	7277.5	-7209
Loxl2	7079.5	-7363
Col8a2	7341.5	-7100
Col14a1	7029.5	-7413
Col8a1	7060.5	-7349
Col4a4	7256.5	-7015
Col6a1	6887.5	-7170
Col1a2	7112.5	-6884
Col6a2	6990.5	-6620
Col3a1	6825.5	-6768
Loxl3	7086.5	-6495
Loxl4	6099.5	-7054
Lox	6388.5	-6132
Col1a1	6801.5	-5269
Col4a5	7299.5	-4615
Col4a1	5401.5	-6011
Pcolce	6881.5	-4622

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Bmp1	-833.5	6565.5	-2394
Col11a1	4153.5	7324.5	-7259
Col11a2	4930.5	3368.5	-3186
Col12a1	2711.5	7358.5	-7275
Col14a1	-6132.5	7029.5	-7413
Col15a1	-6535.5	7067.5	-3977
Col18a1	-6067.5	5446.5	4992
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col7a1	4161.5	6902.5	5428
Col8a1	-7150.5	7060.5	-7349
Col8a2	4475.5	7341.5	-7100
Col9a2	-2728.5	6879.5	4161
Ctsb	-4315.5	-2349.5	1727
Ctsl	-6407.5	4577.5	-478
Ctss	-5693.5	168.5	-6874
Lox	-1869.5	6388.5	-6132
Loxl1	-7029.5	6192.5	-1109
Loxl2	-153.5	7079.5	-7363
Loxl3	-2393.5	7086.5	-6495
Loxl4	30.5	6099.5	-7054
Mmp13	1424.5	-5581.5	-18
Mmp3	-5725.5	3878.5	4649
Mmp9	-6377.5	-6038.5	7780
Pcolce	-3839.5	6881.5	-4622
Pxdn	5676.5	-5990.5	-7124
Tll1	2246.5	5176.5	-4233
Tll2	-6088.5	-4614.5	-6099

---

---

ECM PROTEOGLYCANS

ECM PROTEOGLYCANS

metric	value
setSize	35
pMANOVA	8.08e-12
p.adjustMANOVA	2.03e-10
s.dist	0.827
s.wt_gal3ko	-0.303
s.wt_mst1ox	0.642
s.mst1ox_mst1oxk	-0.425
p.wt_gal3ko	0.00196
p.wt_mst1ox	4.73e-11
p.mst1ox_mst1oxk	1.36e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col5a2	7277.5	-7209
Bgn	7159.5	-7217
Comp	7063.5	-7145
Dcn	7102.5	-7031
Col6a1	6887.5	-7170
Col1a2	7112.5	-6884
Itga9	7059.5	-6787
Fn1	6674.5	-7089
Col6a2	6990.5	-6620
Col3a1	6825.5	-6768
Sparc	6237.5	-7377
Tnc	6533.5	-6356
Serpine1	6577.5	-6210
Matn4	5944.5	-6094
Col1a1	6801.5	-5269
Itga2	6287.5	-5668
Col5a1	6613.5	-4764
App	6935.5	-4058
Itgb1	6225.5	-4513
Tnr	5610.5	-4441

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Agrn	-5940.5	399.5	-7114
App	-3352.5	6935.5	-4058
Bgn	-6197.5	7159.5	-7217
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col3a1	-6278.5	6825.5	-6768
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col9a2	-2728.5	6879.5	4161
Comp	3752.5	7063.5	-7145
Dcn	-997.5	7102.5	-7031
Fn1	-4709.5	6674.5	-7089
Itga2	6056.5	6287.5	-5668
Itga2b	2555.5	798.5	1216
Itga7	1106.5	6293.5	6666
Itga8	5229.5	5355.5	-3660
Itga9	-3441.5	7059.5	-6787
Itgav	-5394.5	7044.5	-2619
Itgax	1974.5	3098.5	-5168
Itgb1	-1133.5	6225.5	-4513
Itgb3	1460.5	4215.5	-1052
Itgb6	3649.5	-6093.5	7065
Matn4	-5465.5	5944.5	-6094
Serpine1	-4895.5	6577.5	-6210
Sparc	-1355.5	6237.5	-7377
Tnc	1229.5	6533.5	-6356
Tnr	-2199.5	5610.5	-4441
Tnxb	-5737.5	5180.5	2171
Vcan	-3082.5	6906.5	-2022
Vtn	-4954.5	-7215.5	7193

---

---

TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS

TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS

metric	value
setSize	11
pMANOVA	0.00131
p.adjustMANOVA	0.00519
s.dist	0.816
s.wt_gal3ko	-0.19
s.wt_mst1ox	0.529
s.mst1ox_mst1oxk	-0.591
p.wt_gal3ko	0.276
p.wt_mst1ox	0.00236
p.mst1ox_mst1oxk	0.000694

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Tnfrsf11b	-6837	6905.5
Eda2r	-6121	6766.5
Tnfrsf1a	-7012	4613.5
Tnfrsf1b	-6682	4409.5
Edar	-2511	7344.5
Tnfrsf14	-4734	3697.5
Tnfsf13b	-5930	2508.5
Eda	-2825	5191.5
Tnfrsf25	-5574	1160.5
Tnfrsf13b	-1558	523.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Eda	-3117.5	5191.5	-2825
Eda2r	394.5	6766.5	-6121
Edar	-6859.5	7344.5	-2511
Tnfrsf11b	6370.5	6905.5	-6837
Tnfrsf13b	1302.5	523.5	-1558
Tnfrsf14	-4879.5	3697.5	-4734
Tnfrsf1a	-6010.5	4613.5	-7012
Tnfrsf1b	-6671.5	4409.5	-6682
Tnfrsf25	2841.5	1160.5	-5574
Tnfsf13	-432.5	-704.5	2423
Tnfsf13b	1989.5	2508.5	-5930

---

---

LAMININ INTERACTIONS

LAMININ INTERACTIONS

metric	value
setSize	15
pMANOVA	3.98e-05
p.adjustMANOVA	0.000304
s.dist	0.814
s.wt_gal3ko	-0.294
s.wt_mst1ox	0.647
s.mst1ox_mst1oxk	-0.396
p.wt_gal3ko	0.0488
p.wt_mst1ox	1.42e-05
p.mst1ox_mst1oxk	0.00789

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col4a3	7307.5	-7227
Col4a4	7256.5	-7015
Col4a5	7299.5	-4615
Col4a1	5401.5	-6011
Nid1	4872.5	-6637
Col4a2	4843.5	-6504
Itgb1	6225.5	-4513
Lama4	3800.5	-4820
Megf6	2608.5	-4053
Itgb4	3931.5	-1988
Itga3	5607.5	-911

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Itga3	-4147.5	5607.5	-911
Itga6	-3992.5	-2635.5	-6569
Itga7	1106.5	6293.5	6666
Itgb1	-1133.5	6225.5	-4513
Itgb4	264.5	3931.5	-1988
Lama4	-1771.5	3800.5	-4820
Megf6	-5354.5	2608.5	-4053
Nid1	476.5	4872.5	-6637
Nid2	2882.5	3636.5	4819

---

---

CHONDROITIN SULFATE BIOSYNTHESIS

CHONDROITIN SULFATE BIOSYNTHESIS

metric	value
setSize	16
pMANOVA	5.08e-05
p.adjustMANOVA	0.000363
s.dist	0.802
s.wt_gal3ko	-0.205
s.wt_mst1ox	0.612
s.mst1ox_mst1oxk	-0.477
p.wt_gal3ko	0.155
p.wt_mst1ox	2.27e-05
p.mst1ox_mst1oxk	0.000957

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Bgn	7159.5	-7217
Dcn	7102.5	-7031
Chsy1	6329.5	-6900
Chsy3	6642.5	-6039
Chpf2	6981.5	-5048
Chst11	4798.5	-6906
Csgalnact2	6170.5	-4539
Chpf	5883.5	-2667
Vcan	6906.5	-2022
Cspg5	2471.5	-2233

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Bgn	-6197.5	7159.5	-7217
Chpf	-7416.5	5883.5	-2667
Chpf2	-2132.5	6981.5	-5048
Chst11	-2866.5	4798.5	-6906
Chst12	-1225.5	4764.5	1815
Chst15	-2466.5	-4215.5	-6643
Chst3	848.5	6625.5	4465
Chst7	-2356.5	-706.5	-1697
Chsy1	5989.5	6329.5	-6900
Chsy3	5119.5	6642.5	-6039
Csgalnact1	252.5	-2273.5	-5637
Csgalnact2	-424.5	6170.5	-4539
Cspg4	-4438.5	7055.5	3281
Cspg5	-2446.5	2471.5	-2233
Dcn	-997.5	7102.5	-7031
Vcan	-3082.5	6906.5	-2022

---

---

DEGRADATION OF CYSTEINE AND HOMOCYSTEINE

DEGRADATION OF CYSTEINE AND HOMOCYSTEINE

metric	value
setSize	10
pMANOVA	0.00385
p.adjustMANOVA	0.0127
s.dist	0.79
s.wt_gal3ko	0.0738
s.wt_mst1ox	-0.586
s.mst1ox_mst1oxk	0.524
p.wt_gal3ko	0.686
p.wt_mst1ox	0.00133
p.mst1ox_mst1oxk	0.0041

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Txn2	-6722.5	7242
Ethe1	-6794.5	6895
Suox	-6053.5	7309
Slc25a10	-6228.5	5513
Tst	-6991.5	4722
Cdo1	-2351.5	7358
Mpst	-5400.5	3172
Ado	-3365.5	4634
Cth	-4782.5	1833

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Ado	3246.5	-3365.5	4634
Cdo1	5046.5	-2351.5	7358
Cth	-3514.5	-4782.5	1833
Ethe1	-4567.5	-6794.5	6895
Fmo1	6070.5	2281.5	-6813
Mpst	3321.5	-5400.5	3172
Slc25a10	-5404.5	-6228.5	5513
Suox	338.5	-6053.5	7309
Tst	5683.5	-6991.5	4722
Txn2	-3856.5	-6722.5	7242

---

---

COLLAGEN FORMATION

COLLAGEN FORMATION

metric	value
setSize	65
pMANOVA	2.33e-19
p.adjustMANOVA	1.75e-17
s.dist	0.788
s.wt_gal3ko	-0.29
s.wt_mst1ox	0.586
s.mst1ox_mst1oxk	-0.439
p.wt_gal3ko	5.16e-05
p.wt_mst1ox	3.06e-16
p.mst1ox_mst1oxk	9.21e-10

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col12a1	7358.5	-7275
Col11a1	7324.5	-7259
Col4a3	7307.5	-7227
Col5a2	7277.5	-7209
Loxl2	7079.5	-7363
Col8a2	7341.5	-7100
Col14a1	7029.5	-7413
Col8a1	7060.5	-7349
Col4a4	7256.5	-7015
Col22a1	7259.5	-6901
Adamts2	6841.5	-7232
Col6a1	6887.5	-7170
Col1a2	7112.5	-6884
Col16a1	7242.5	-6756
Col6a2	6990.5	-6620
Col3a1	6825.5	-6768
Loxl3	7086.5	-6495
Plod2	6408.5	-7120
Pcolce2	7041.5	-6375
Loxl4	6099.5	-7054

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Adamts14	-102.5	5846.5	2129
Adamts2	-4279.5	6841.5	-7232
Adamts3	5490.5	-4018.5	-7310
Bmp1	-833.5	6565.5	-2394
Col11a1	4153.5	7324.5	-7259
Col11a2	4930.5	3368.5	-3186
Col12a1	2711.5	7358.5	-7275
Col13a1	5587.5	5244.5	-6927
Col14a1	-6132.5	7029.5	-7413
Col15a1	-6535.5	7067.5	-3977
Col16a1	-3835.5	7242.5	-6756
Col18a1	-6067.5	5446.5	4992
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col20a1	110.5	6720.5	7524
Col22a1	-4905.5	7259.5	-6901
Col23a1	-6602.5	908.5	-3080
Col25a1	-1661.5	-1726.5	-3781
Col26a1	-6596.5	5088.5	-5287
Col28a1	4846.5	3652.5	-3687
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col7a1	4161.5	6902.5	5428
Col8a1	-7150.5	7060.5	-7349
Col8a2	4475.5	7341.5	-7100
Col9a2	-2728.5	6879.5	4161
Colgalt1	-3011.5	3585.5	-2325
Colgalt2	-2515.5	-1962.5	-4249
Ctsb	-4315.5	-2349.5	1727
Ctsl	-6407.5	4577.5	-478
Ctss	-5693.5	168.5	-6874
Lox	-1869.5	6388.5	-6132
Loxl1	-7029.5	6192.5	-1109
Loxl2	-153.5	7079.5	-7363
Loxl3	-2393.5	7086.5	-6495
Loxl4	30.5	6099.5	-7054
Mmp13	1424.5	-5581.5	-18
Mmp3	-5725.5	3878.5	4649
Mmp9	-6377.5	-6038.5	7780
P3h2	-3515.5	7439.5	7124
P3h3	-3743.5	6865.5	-5069
P4ha1	-1889.5	6829.5	-3830
P4ha2	-7450.5	-3947.5	-2123
P4hb	-4929.5	5325.5	-4687
Pcolce	-3839.5	6881.5	-4622
Pcolce2	7097.5	7041.5	-6375
Plod1	2492.5	2663.5	-3359
Plod2	7007.5	6408.5	-7120
Plod3	-7202.5	5321.5	2737
Pxdn	5676.5	-5990.5	-7124
Serpinh1	4796.5	4119.5	-1160
Tll1	2246.5	5176.5	-4233
Tll2	-6088.5	-4614.5	-6099

---

---

TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY

TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY

metric	value
setSize	11
pMANOVA	0.00212
p.adjustMANOVA	0.00784
s.dist	0.756
s.wt_gal3ko	-0.444
s.wt_mst1ox	0.469
s.mst1ox_mst1oxk	-0.392
p.wt_gal3ko	0.0108
p.wt_mst1ox	0.00703
p.mst1ox_mst1oxk	0.0245

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	wt_gal3ko
Traf3	7096.5	-7111.5
Tnfrsf12a	6945.5	-6913.5
Map3k14	6115.5	-5202.5
Cd40	4805.5	-3041.5
Traf2	1946.5	-6924.5
Ltbr	3157.5	-3322.5
Birc3	1349.5	-7400.5
Tnfrsf11a	3373.5	-540.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Birc2	1006.5	-4357.5	-3517
Birc3	-7400.5	1349.5	-4484
Cd40	-3041.5	4805.5	-6072
Ltbr	-3322.5	3157.5	317
Map3k14	-5202.5	6115.5	-75
Tnfrsf11a	-540.5	3373.5	-4582
Tnfrsf12a	-6913.5	6945.5	2634
Tnfsf12	1085.5	4447.5	116
Tnfsf13b	1989.5	2508.5	-5930
Traf2	-6924.5	1946.5	-3271
Traf3	-7111.5	7096.5	-5838

---

---

METABOLISM OF COFACTORS

METABOLISM OF COFACTORS

metric	value
setSize	23
pMANOVA	1.23e-06
p.adjustMANOVA	1.46e-05
s.dist	0.752
s.wt_gal3ko	-0.109
s.wt_mst1ox	-0.623
s.mst1ox_mst1oxk	0.408
p.wt_gal3ko	0.364
p.wt_mst1ox	2.35e-07
p.mst1ox_mst1oxk	0.000714

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Coq9	-7557.5	7535
Stard7	-7598.5	7356
Coq3	-7352.5	7383
Coq5	-7654.5	6850
Gchfr	-6940.5	6954
Coq6	-7492.5	6315
Coq2	-7455.5	6111
Pdss1	-7180.5	3645
Idh1	-6315.5	3991
Spr	-3418.5	6415
Coq7	-6668.5	3123
Pdss2	-7442.5	2391
Calm3	-3155.5	4363
Coq4	-5872.5	1422
Pts	-4024.5	1474
Aco1	-5954.5	945
Hpdl	-2965.5	422

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Aco1	331.5	-5954.5	945
Akt1	6469.5	-5946.5	-4433
Calm1	-5300.5	-5245.5	-419
Calm2	-1804.5	1781.5	-2548
Calm3	3520.5	-3155.5	4363
Coq2	-14.5	-7455.5	6111
Coq3	-3240.5	-7352.5	7383
Coq4	-2876.5	-5872.5	1422
Coq5	-4802.5	-7654.5	6850
Coq6	-3812.5	-7492.5	6315
Coq7	-3193.5	-6668.5	3123
Coq9	-2166.5	-7557.5	7535
Gch1	7682.5	93.5	7677
Gchfr	-4434.5	-6940.5	6954
Hpdl	3316.5	-2965.5	422
Hsp90aa1	4116.5	5718.5	3967
Idh1	4132.5	-6315.5	3991
Nos3	-2579.5	-4396.5	-5138
Pdss1	-4319.5	-7180.5	3645
Pdss2	-4692.5	-7442.5	2391
Pts	-1066.5	-4024.5	1474
Spr	-4888.5	-3418.5	6415
Stard7	2197.5	-7598.5	7356

---

---

ELASTIC FIBRE FORMATION

ELASTIC FIBRE FORMATION

metric	value
setSize	36
pMANOVA	1.41e-09
p.adjustMANOVA	2.58e-08
s.dist	0.733
s.wt_gal3ko	-0.148
s.wt_mst1ox	0.61
s.mst1ox_mst1oxk	-0.379
p.wt_gal3ko	0.124
p.wt_mst1ox	2.34e-10
p.mst1ox_mst1oxk	8.43e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Mfap5	7124.5	-7388
Loxl2	7079.5	-7363
Fbln5	6845.5	-7345
Tgfb2	7422.5	-6763
Tgfb3	7271.5	-6815
Ltbp2	7122.5	-6669
Fn1	6674.5	-7089
Mfap4	6413.5	-7185
Loxl3	7086.5	-6495
Loxl4	6099.5	-7054
Lox	6388.5	-6132
Bmp4	6926.5	-5044
Fbn1	6321.5	-4766
Itgb1	6225.5	-4513
Itga5	7129.5	-3675
Itga8	5355.5	-3660
Itgav	7044.5	-2619
Emilin1	6488.5	-2483
Itgb8	6689.5	-2392
Efemp2	5909.5	-2373

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Bmp2	6085.5	2246.5	-1997
Bmp4	5948.5	6926.5	-5044
Bmp7	-2734.5	-7037.5	-4776
Efemp2	1132.5	5909.5	-2373
Eln	1287.5	4450.5	-44
Emilin1	-7325.5	6488.5	-2483
Emilin2	6475.5	-6937.5	1937
Fbln2	-6430.5	6428.5	1823
Fbln5	-5555.5	6845.5	-7345
Fbn1	-6367.5	6321.5	-4766
Fbn2	6190.5	5227.5	-1544
Fn1	-4709.5	6674.5	-7089
Furin	-1219.5	-2916.5	5518
Itga5	4014.5	7129.5	-3675
Itga8	5229.5	5355.5	-3660
Itgav	-5394.5	7044.5	-2619
Itgb1	-1133.5	6225.5	-4513
Itgb3	1460.5	4215.5	-1052
Itgb6	3649.5	-6093.5	7065
Itgb8	984.5	6689.5	-2392
Lox	-1869.5	6388.5	-6132
Loxl1	-7029.5	6192.5	-1109
Loxl2	-153.5	7079.5	-7363
Loxl3	-2393.5	7086.5	-6495
Loxl4	30.5	6099.5	-7054
Ltbp1	6896.5	5576.5	-1370
Ltbp2	-2386.5	7122.5	-6669
Ltbp3	-4654.5	7062.5	-1807
Ltbp4	-6019.5	6306.5	-1751
Mfap2	1709.5	3784.5	4756
Mfap4	-3225.5	6413.5	-7185
Mfap5	-2153.5	7124.5	-7388
Tgfb1	-683.5	5780.5	-1753
Tgfb2	-6188.5	7422.5	-6763
Tgfb3	-6446.5	7271.5	-6815
Vtn	-4954.5	-7215.5	7193

---

---

PEROXISOMAL PROTEIN IMPORT

PEROXISOMAL PROTEIN IMPORT

metric	value
setSize	61
pMANOVA	4.08e-15
p.adjustMANOVA	1.47e-13
s.dist	0.725
s.wt_gal3ko	0.0126
s.wt_mst1ox	-0.566
s.mst1ox_mst1oxk	0.454
p.wt_gal3ko	0.865
p.wt_mst1ox	2.03e-14
p.mst1ox_mst1oxk	8.93e-10

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Gstk1	-7713.5	7779
Ephx2	-7668.5	7699
Acot1	-7501.5	7716
Ech1	-7535.5	7680
Crat	-7634.5	7440
Hsd17b4	-7458.5	7386
Amacr	-7333.5	7354
Nudt7	-7132.5	7515
Acot2	-7351.5	7256
Phyh	-7748.5	6834
Mlycd	-6985.5	7253
Gnpat	-7739.5	6437
Acox1	-7669.5	6296
Scp2	-7418.5	6298
Pecr	-6207.5	7055
Eci2	-7657.5	5688
Dhrs4	-7386.5	5410
Acot4	-5724.5	6979
Mpv17	-6066.5	6195
Ddo	-5188.5	6984

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acaa1b	1513.5	-373.5	5040
Acot1	6765.5	-7501.5	7716
Acot2	-2155.5	-7351.5	7256
Acot3	3092.5	-6542.5	1109
Acot4	-4166.5	-5724.5	6979
Acot8	-3204.5	-597.5	2283
Acox1	-7466.5	-7669.5	6296
Acox2	-5946.5	1835.5	3469
Acox3	-1267.5	-3569.5	-1454
Amacr	2564.5	-7333.5	7354
Cat	-6637.5	-1458.5	7462
Crat	-1974.5	-7634.5	7440
Crot	-1.5	-2783.5	-5131
Dao	-334.5	-109.5	5894
Ddo	5791.5	-5188.5	6984
Decr2	4521.5	-5240.5	6052
Dhrs4	-6108.5	-7386.5	5410
Ech1	3983.5	-7535.5	7680
Eci2	1790.5	-7657.5	5688
Ehhadh	6658.5	-6680.5	2218
Ephx2	-6306.5	-7668.5	7699
Gnpat	-4065.5	-7739.5	6437
Gstk1	4525.5	-7713.5	7779
Hacl1	5831.5	-725.5	2670
Hao2	-1743.5	551.5	4888
Hmgcl	-1489.5	-5039.5	6149
Hsd17b4	-5866.5	-7458.5	7386
Ide	6789.5	-4616.5	4136
Idh1	4132.5	-6315.5	3991
Lonp2	-7035.5	-7252.5	3406
Mlycd	2542.5	-6985.5	7253
Mpv17	5614.5	-6066.5	6195
Nos2	-2603.5	-6044.5	-3263
Nudt19	3534.5	-6316.5	3921
Nudt7	-1789.5	-7132.5	7515
Paox	7025.5	-2565.5	-5556
Pecr	-2982.5	-6207.5	7055
Pex1	4223.5	-5296.5	2549
Pex10	-1500.5	-6303.5	3998
Pex12	5964.5	-3637.5	-2156
Pex13	-3600.5	-5560.5	1966
Pex14	3909.5	-2411.5	1465
Pex2	2886.5	-6674.5	1779
Pex26	6922.5	-2788.5	846
Pex5	-5058.5	3086.5	5365
Pex6	-2296.5	-5487.5	4436
Pex7	867.5	-6802.5	3305
Phyh	-1008.5	-7748.5	6834
Pipox	832.5	2443.5	2382
Rps27a	393.5	-996.5	888
Scp2	-6454.5	-7418.5	6298
Slc27a2	-3667.5	531.5	3822
Tysnd1	-4011.5	-3190.5	2428
Uba52	2997.5	-3735.5	-311
Ubb	-214.5	-1647.5	-3950
Ubc	7553.5	-2084.5	4118
Ube2d1	-3491.5	-5930.5	1502
Ube2d2a	-2816.5	-4957.5	6732
Ube2d3	3186.5	3793.5	-470
Usp9x	-979.5	-2880.5	-1610
Zfand6	2211.5	-5416.5	-3774

---

---

CS DS DEGRADATION

CS DS DEGRADATION

metric	value
setSize	11
pMANOVA	0.000453
p.adjustMANOVA	0.00223
s.dist	0.717
s.wt_gal3ko	-0.243
s.wt_mst1ox	0.67
s.mst1ox_mst1oxk	-0.0758
p.wt_gal3ko	0.164
p.wt_mst1ox	0.000118
p.mst1ox_mst1oxk	0.663

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	wt_gal3ko
Bgn	7159.5	-6197.5
Cspg4	7055.5	-4438.5
Arsb	6729.5	-3804.5
Vcan	6906.5	-3082.5
Ids	3831.5	-3474.5
Dcn	7102.5	-997.5
Cspg5	2471.5	-2446.5
Hexb	6262.5	-474.5
Hyal1	6393.5	-391.5
Hexa	6102.5	-397.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Arsb	-3804.5	6729.5	-4255
Bgn	-6197.5	7159.5	-7217
Cspg4	-4438.5	7055.5	3281
Cspg5	-2446.5	2471.5	-2233
Dcn	-997.5	7102.5	-7031
Hexa	-397.5	6102.5	2233
Hexb	-474.5	6262.5	-6663
Hyal1	-391.5	6393.5	7164
Ids	-3474.5	3831.5	5542
Idua	6193.5	-5790.5	6973
Vcan	-3082.5	6906.5	-2022

---

---

AFLATOXIN ACTIVATION AND DETOXIFICATION

AFLATOXIN ACTIVATION AND DETOXIFICATION

metric	value
setSize	10
pMANOVA	0.00747
p.adjustMANOVA	0.0213
s.dist	0.71
s.wt_gal3ko	-0.0964
s.wt_mst1ox	-0.365
s.mst1ox_mst1oxk	0.602
p.wt_gal3ko	0.598
p.wt_mst1ox	0.0456
p.mst1ox_mst1oxk	0.000984

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Mgst3	7173	-6692.5
Mgst1	6447	-7346.5
Acy3	6765	-6263.5
Akr7a5	6317	-6126.5
Acy1	5125	-6775.5
Ggt5	3992	-6467.5
Dpep1	7529	-1821.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acy1	4892.5	-6775.5	5125
Acy3	-7385.5	-6263.5	6765
Akr7a5	4583.5	-6126.5	6317
Dpep1	-6270.5	-1821.5	7529
Dpep2	487.5	5761.5	-7134
Ggt1	26.5	676.5	5187
Ggt5	-2836.5	-6467.5	3992
Ggt7	-7191.5	5479.5	6365
Mgst1	1749.5	-7346.5	6447
Mgst3	5344.5	-6692.5	7173

---

---

SYNDECAN INTERACTIONS

SYNDECAN INTERACTIONS

metric	value
setSize	14
pMANOVA	0.00145
p.adjustMANOVA	0.00564
s.dist	0.707
s.wt_gal3ko	-0.311
s.wt_mst1ox	0.419
s.mst1ox_mst1oxk	-0.476
p.wt_gal3ko	0.0442
p.wt_mst1ox	0.00659
p.mst1ox_mst1oxk	0.00202

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Fn1	-7089	6674.5
Sdc2	-5683	7146.5
Itga2	-5668	6287.5
Sdc3	-7141	4180.5
Itgb1	-4513	6225.5
Itgav	-2619	7044.5
Sdc1	-2888	5343.5
Tgfb1	-1753	5780.5
Itgb4	-1988	3931.5
Itgb3	-1052	4215.5
Sdc4	-3077	106.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Fgf2	-75.5	-4844.5	-5254
Fn1	-4709.5	6674.5	-7089
Itga2	6056.5	6287.5	-5668
Itga6	-3992.5	-2635.5	-6569
Itgav	-5394.5	7044.5	-2619
Itgb1	-1133.5	6225.5	-4513
Itgb3	1460.5	4215.5	-1052
Itgb4	264.5	3931.5	-1988
Sdc1	-4854.5	5343.5	-2888
Sdc2	-1162.5	7146.5	-5683
Sdc3	-5505.5	4180.5	-7141
Sdc4	-7387.5	106.5	-3077
Tgfb1	-683.5	5780.5	-1753
Vtn	-4954.5	-7215.5	7193

---

---

BIOTIN TRANSPORT AND METABOLISM

BIOTIN TRANSPORT AND METABOLISM

metric	value
setSize	11
pMANOVA	0.00498
p.adjustMANOVA	0.0154
s.dist	0.704
s.wt_gal3ko	-0.223
s.wt_mst1ox	-0.423
s.mst1ox_mst1oxk	0.516
p.wt_gal3ko	0.201
p.wt_mst1ox	0.015
p.mst1ox_mst1oxk	0.00305

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Mccc2	7683	-7760.5
Mccc1	7167	-7768.5
Acacb	7011	-7427.5
Pcca	6554	-7764.5
Pcx	6633	-6534.5
Pccb	2577	-7517.5
Slc5a6	1952	-6540.5
Acaca	1795	-251.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Acaca	692.5	-251.5	1795
Acacb	2853.5	-7427.5	7011
Btd	-6874.5	6014.5	-520
Hlcs	-989.5	4497.5	5448
Mccc1	7359.5	-7768.5	7167
Mccc2	-4217.5	-7760.5	7683
Pcca	-3076.5	-7764.5	6554
Pccb	-4333.5	-7517.5	2577
Pcx	-6408.5	-6534.5	6633
Pdzd11	4456.5	3630.5	-948
Slc5a6	-7309.5	-6540.5	1952

---

---

SULFUR AMINO ACID METABOLISM

SULFUR AMINO ACID METABOLISM

metric	value
setSize	19
pMANOVA	0.000133
p.adjustMANOVA	0.000806
s.dist	0.703
s.wt_gal3ko	-0.0513
s.wt_mst1ox	-0.488
s.mst1ox_mst1oxk	0.504
p.wt_gal3ko	0.699
p.wt_mst1ox	0.000234
p.mst1ox_mst1oxk	0.000142

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Txn2	7242	-6722.5
Adi1	6249	-7704.5
Ethe1	6895	-6794.5
Suox	7309	-6053.5
Slc25a10	5513	-6228.5
Tst	4722	-6991.5
Mtr	4042	-7339.5
Mri1	6820	-4210.5
Mtap	4915	-5773.5
Cdo1	7358	-2351.5
Mpst	3172	-5400.5
Ado	4634	-3365.5
Mtrr	2025	-5635.5
Cth	1833	-4782.5
Enoph1	2415	-262.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Adi1	1721.5	-7704.5	6249
Ado	3246.5	-3365.5	4634
Ahcy	-2147.5	2387.5	-128
Cbs	-2266.5	496.5	3198
Cdo1	5046.5	-2351.5	7358
Cth	-3514.5	-4782.5	1833
Enoph1	-4965.5	-262.5	2415
Ethe1	-4567.5	-6794.5	6895
Fmo1	6070.5	2281.5	-6813
Mat1a	-1466.5	571.5	5186
Mpst	3321.5	-5400.5	3172
Mri1	-2381.5	-4210.5	6820
Mtap	-4511.5	-5773.5	4915
Mtr	7666.5	-7339.5	4042
Mtrr	-4022.5	-5635.5	2025
Slc25a10	-5404.5	-6228.5	5513
Suox	338.5	-6053.5	7309
Tst	5683.5	-6991.5	4722
Txn2	-3856.5	-6722.5	7242

---

---

PYRUVATE METABOLISM

PYRUVATE METABOLISM

metric	value
setSize	42
pMANOVA	7.2e-10
p.adjustMANOVA	1.38e-08
s.dist	0.697
s.wt_gal3ko	0.106
s.wt_mst1ox	-0.569
s.mst1ox_mst1oxk	0.388
p.wt_gal3ko	0.233
p.wt_mst1ox	1.71e-10
p.mst1ox_mst1oxk	1.38e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Dlat	-7564.5	7734
Gpt	-7508.5	7783
Pdhx	-7696.5	7400
Me3	-7579.5	7465
Fahd1	-7642.5	7361
Ldhb	-7702.5	7303
Pdpr	-7613.5	7285
Pdk2	-7201.5	7080
Pdp2	-7368.5	6738
Vdac1	-7461.5	6640
Pdhb	-7319.5	6706
Gstz1	-7264.5	6407
Pcx	-6534.5	6633
Pdha1	-7382.5	5384
Pgam5	-5698.5	5611
Gid8	-5117.5	6057
Dld	-7624.5	3955
Glo1	-5785.5	3860
Me1	-7018.5	3143
Sirt4	-5456.5	3782

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Armc8	-2745.5	-4929.5	-2260
Dlat	-2899.5	-7564.5	7734
Dld	3637.5	-7624.5	3955
Fahd1	3702.5	-7642.5	7361
Gid4	2536.5	-7209.5	-3928
Gid8	-1477.5	-5117.5	6057
Glo1	-5923.5	-5785.5	3860
Gpt	3393.5	-7508.5	7783
Gstz1	6665.5	-7264.5	6407
Hagh	134.5	-1200.5	6544
Ldha	3270.5	-4720.5	1144
Ldhal6b	5565.5	-1655.5	-4896
Ldhb	-439.5	-7702.5	7303
Maea	-4650.5	-1825.5	4532
Me1	7.5	-7018.5	3143
Me2	-4662.5	4725.5	2132
Me3	-309.5	-7579.5	7465
Mkln1	3281.5	-4361.5	601
Nek1	-3162.5	-4082.5	-3818
Pcx	-6408.5	-6534.5	6633
Pdha1	2537.5	-7382.5	5384
Pdhb	1452.5	-7319.5	6706
Pdhx	-3741.5	-7696.5	7400
Pdk1	1325.5	-6558.5	2799
Pdk2	3026.5	-7201.5	7080
Pdk3	7402.5	7005.5	-4035
Pdk4	7318.5	1859.5	5809
Pdp1	1520.5	-4680.5	-851
Pdp2	-3200.5	-7368.5	6738
Pdpr	-6510.5	-7613.5	7285
Pgam5	2323.5	-5698.5	5611
Pkm	-5709.5	-6577.5	976
Ranbp9	4679.5	-6411.5	1636
Rmnd5a	-170.5	-5637.5	-284
Rmnd5b	5144.5	5434.5	3888
Rps27a	393.5	-996.5	888
Sirt4	1853.5	-5456.5	3782
Uba52	2997.5	-3735.5	-311
Ubb	-214.5	-1647.5	-3950
Ubc	7553.5	-2084.5	4118
Vdac1	2205.5	-7461.5	6640
Wdr26	5364.5	652.5	-3159

---

---

MOLECULES ASSOCIATED WITH ELASTIC FIBRES

MOLECULES ASSOCIATED WITH ELASTIC FIBRES

metric	value
setSize	29
pMANOVA	4.95e-07
p.adjustMANOVA	6.75e-06
s.dist	0.693
s.wt_gal3ko	-0.143
s.wt_mst1ox	0.584
s.mst1ox_mst1oxk	-0.345
p.wt_gal3ko	0.184
p.wt_mst1ox	5.33e-08
p.mst1ox_mst1oxk	0.00132

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Mfap5	7124.5	-7388
Fbln5	6845.5	-7345
Tgfb2	7422.5	-6763
Tgfb3	7271.5	-6815
Ltbp2	7122.5	-6669
Fn1	6674.5	-7089
Mfap4	6413.5	-7185
Bmp4	6926.5	-5044
Fbn1	6321.5	-4766
Itgb1	6225.5	-4513
Itga8	5355.5	-3660
Itgav	7044.5	-2619
Emilin1	6488.5	-2483
Itgb8	6689.5	-2392
Efemp2	5909.5	-2373
Ltbp3	7062.5	-1807
Ltbp4	6306.5	-1751
Tgfb1	5780.5	-1753
Fbn2	5227.5	-1544
Ltbp1	5576.5	-1370

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Bmp2	6085.5	2246.5	-1997
Bmp4	5948.5	6926.5	-5044
Bmp7	-2734.5	-7037.5	-4776
Efemp2	1132.5	5909.5	-2373
Eln	1287.5	4450.5	-44
Emilin1	-7325.5	6488.5	-2483
Emilin2	6475.5	-6937.5	1937
Fbln2	-6430.5	6428.5	1823
Fbln5	-5555.5	6845.5	-7345
Fbn1	-6367.5	6321.5	-4766
Fbn2	6190.5	5227.5	-1544
Fn1	-4709.5	6674.5	-7089
Itga8	5229.5	5355.5	-3660
Itgav	-5394.5	7044.5	-2619
Itgb1	-1133.5	6225.5	-4513
Itgb3	1460.5	4215.5	-1052
Itgb6	3649.5	-6093.5	7065
Itgb8	984.5	6689.5	-2392
Ltbp1	6896.5	5576.5	-1370
Ltbp2	-2386.5	7122.5	-6669
Ltbp3	-4654.5	7062.5	-1807
Ltbp4	-6019.5	6306.5	-1751
Mfap2	1709.5	3784.5	4756
Mfap4	-3225.5	6413.5	-7185
Mfap5	-2153.5	7124.5	-7388
Tgfb1	-683.5	5780.5	-1753
Tgfb2	-6188.5	7422.5	-6763
Tgfb3	-6446.5	7271.5	-6815
Vtn	-4954.5	-7215.5	7193

---

---

PEROXISOMAL LIPID METABOLISM

PEROXISOMAL LIPID METABOLISM

metric	value
setSize	27
pMANOVA	3.82e-06
p.adjustMANOVA	4.04e-05
s.dist	0.689
s.wt_gal3ko	-0.0372
s.wt_mst1ox	-0.472
s.mst1ox_mst1oxk	0.501
p.wt_gal3ko	0.738
p.wt_mst1ox	2.23e-05
p.mst1ox_mst1oxk	6.66e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_mst1ox
Crat	7440	-7634.5
Hsd17b4	7386	-7458.5
Amacr	7354	-7333.5
Phyh	6834	-7748.5
Mlycd	7253	-6985.5
Acox1	6296	-7669.5
Scp2	6298	-7418.5
Pecr	7055	-6207.5
Eci2	5688	-7657.5
Abcd1	6524	-6415.5
Acot4	6979	-5724.5
Decr2	6052	-5240.5
Nudt19	3921	-6316.5
Acot6	5103	-3310.5
Ehhadh	2218	-6680.5
Hacl1	2670	-725.5
Acaa1b	5040	-373.5
Acot8	2283	-597.5
Aldh3a2	261	-842.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Abcd1	4494.5	-6415.5	6524
Acaa1b	1513.5	-373.5	5040
Acbd4	5668.5	4489.5	5707
Acbd5	367.5	4863.5	-2692
Acot4	-4166.5	-5724.5	6979
Acot6	1422.5	-3310.5	5103
Acot8	-3204.5	-597.5	2283
Acox1	-7466.5	-7669.5	6296
Acox2	-5946.5	1835.5	3469
Acox3	-1267.5	-3569.5	-1454
Aldh3a2	-2274.5	-842.5	261
Amacr	2564.5	-7333.5	7354
Crat	-1974.5	-7634.5	7440
Crot	-1.5	-2783.5	-5131
Decr2	4521.5	-5240.5	6052
Eci2	1790.5	-7657.5	5688
Ehhadh	6658.5	-6680.5	2218
Hacl1	5831.5	-725.5	2670
Hao2	-1743.5	551.5	4888
Hsd17b4	-5866.5	-7458.5	7386
Mlycd	2542.5	-6985.5	7253
Nudt19	3534.5	-6316.5	3921
Pecr	-2982.5	-6207.5	7055
Phyh	-1008.5	-7748.5	6834
Scp2	-6454.5	-7418.5	6298
Slc25a17	1474.5	-5210.5	-3171
Slc27a2	-3667.5	531.5	3822

---

---

MITOTIC TELOPHASE CYTOKINESIS

MITOTIC TELOPHASE CYTOKINESIS

metric	value
setSize	13
pMANOVA	0.000107
p.adjustMANOVA	0.000676
s.dist	0.687
s.wt_gal3ko	0.125
s.wt_mst1ox	0.0466
s.mst1ox_mst1oxk	-0.674
p.wt_gal3ko	0.436
p.wt_mst1ox	0.771
p.mst1ox_mst1oxk	2.55e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	mst1ox_mst1oxk	wt_gal3ko
Pds5b	-5315	7427.5
Nipbl	-4813	5087.5
Stag1	-4854	4443.5
Mau2	-3457	6004.5
Rad21	-4409	4156.5
Smc3	-2920	3096.5
Stag2	-3987	1888.5

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Kif20a	-1024.5	4755.5	-6896
Kif23	-6056.5	1842.5	-6286
Mau2	6004.5	-1330.5	-3457
Nipbl	5087.5	-506.5	-4813
Pds5a	-3602.5	-2281.5	-4975
Pds5b	7427.5	-2005.5	-5315
Plk1	-890.5	4988.5	-6765
Rad21	4156.5	-5058.5	-4409
Smc1a	-2289.5	933.5	-3841
Smc3	3096.5	-2529.5	-2920
Stag1	4443.5	1724.5	-4854
Stag2	1888.5	3781.5	-3987
Wapl	-4914.5	-1991.5	-5743

---

---

INTEGRIN CELL SURFACE INTERACTIONS

INTEGRIN CELL SURFACE INTERACTIONS

metric	value
setSize	65
pMANOVA	3.82e-14
p.adjustMANOVA	1.23e-12
s.dist	0.679
s.wt_gal3ko	-0.25
s.wt_mst1ox	0.476
s.mst1ox_mst1oxk	-0.415
p.wt_gal3ko	0.000487
p.wt_mst1ox	3.14e-11
p.mst1ox_mst1oxk	7.4e-09

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_mst1ox	mst1ox_mst1oxk
Col4a3	7307.5	-7227
Col5a2	7277.5	-7209
Col8a2	7341.5	-7100
Col8a1	7060.5	-7349
Cd44	7409.5	-6997
Col4a4	7256.5	-7015
Comp	7063.5	-7145
Col6a1	6887.5	-7170
Col1a2	7112.5	-6884
Col16a1	7242.5	-6756
Itga9	7059.5	-6787
Fn1	6674.5	-7089
Itga11	6735.5	-6966
Col6a2	6990.5	-6620
Col3a1	6825.5	-6768
Thbs1	6417.5	-6619
Tnc	6533.5	-6356
Spp1	6764.5	-5820
Itga10	5551.5	-6580
Col13a1	5244.5	-6927

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Bsg	119.5	-7439.5	5927
Cd44	3773.5	7409.5	-6997
Cd47	-4198.5	4208.5	-4051
Col13a1	5587.5	5244.5	-6927
Col16a1	-3835.5	7242.5	-6756
Col18a1	-6067.5	5446.5	4992
Col1a1	-5503.5	6801.5	-5269
Col1a2	-4728.5	7112.5	-6884
Col3a1	-6278.5	6825.5	-6768
Col4a1	-6405.5	5401.5	-6011
Col4a2	-6463.5	4843.5	-6504
Col4a3	-6741.5	7307.5	-7227
Col4a4	-7068.5	7256.5	-7015
Col4a5	4319.5	7299.5	-4615
Col4a6	1579.5	4829.5	7012
Col5a1	-4525.5	6613.5	-4764
Col5a2	-3971.5	7277.5	-7209
Col5a3	-996.5	-2248.5	6912
Col6a1	-5925.5	6887.5	-7170
Col6a2	-4973.5	6990.5	-6620
Col6a3	-7051.5	6398.5	-3148
Col6a6	611.5	-6117.5	7731
Col7a1	4161.5	6902.5	5428
Col8a1	-7150.5	7060.5	-7349
Col8a2	4475.5	7341.5	-7100
Col9a2	-2728.5	6879.5	4161
Comp	3752.5	7063.5	-7145
F11r	4062.5	-4231.5	-5093
Fbn1	-6367.5	6321.5	-4766
Fga	1846.5	827.5	4316
Fgb	-982.5	1410.5	3890
Fn1	-4709.5	6674.5	-7089
Icam1	-7462.5	4009.5	-5567
Icam2	-4014.5	-4628.5	-6267
Itga1	-4517.5	-3033.5	-6173
Itga10	3199.5	5551.5	-6580
Itga11	-5430.5	6735.5	-6966
Itga2	6056.5	6287.5	-5668
Itga2b	2555.5	798.5	1216
Itga3	-4147.5	5607.5	-911
Itga4	-2974.5	721.5	-5528
Itga5	4014.5	7129.5	-3675
Itga6	-3992.5	-2635.5	-6569
Itga8	5229.5	5355.5	-3660
Itga9	-3441.5	7059.5	-6787
Itgal	5038.5	-2234.5	1317
Itgam	-4046.5	-1512.5	111
Itgav	-5394.5	7044.5	-2619
Itgax	1974.5	3098.5	-5168
Itgb1	-1133.5	6225.5	-4513
Itgb2	-4087.5	-2305.5	-123
Itgb3	1460.5	4215.5	-1052
Itgb6	3649.5	-6093.5	7065
Itgb7	2286.5	2772.5	-5849
Itgb8	984.5	6689.5	-2392
Jam2	2742.5	-5739.5	-3698
Jam3	-4050.5	4237.5	4030
Lum	-3080.5	6544.5	6367
Pecam1	-7344.5	-6401.5	-6668
Spp1	399.5	6764.5	-5820
Thbs1	-3222.5	6417.5	-6619
Tnc	1229.5	6533.5	-6356
Vcam1	-7115.5	2539.5	-6311
Vtn	-4954.5	-7215.5	7193
Vwf	-6656.5	1086.5	-5706

---

---

GENERATION OF SECOND MESSENGER MOLECULES

GENERATION OF SECOND MESSENGER MOLECULES

metric	value
setSize	12
pMANOVA	0.000217
p.adjustMANOVA	0.00119
s.dist	0.677
s.wt_gal3ko	-0.518
s.wt_mst1ox	-0.18
s.mst1ox_mst1oxk	-0.396
p.wt_gal3ko	0.00189
p.wt_mst1ox	0.281
p.mst1ox_mst1oxk	0.0174

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	wt_gal3ko	mst1ox_mst1oxk
H2-Aa	-5973.5	-5687
H2-Ab1	-6190.5	-5037
H2-Eb1	-6179.5	-4195
Pak2	-7076.5	-3201
Plcg2	-7471.5	-2867
Pak1	-6577.5	-2462
Plcg1	-2125.5	-6517
Pak3	-489.5	-1097

Click HERE to show all gene set members

All member genes

	wt_gal3ko	wt_mst1ox	mst1ox_mst1oxk
Cd247	1310.5	-4345.5	-3358
Cd4	-4891.5	-1488.5	3013
H2-Aa	-5973.5	-6706.5	-5687
H2-Ab1	-6190.5	-6262.5	-5037
H2-Eb1	-6179.5	-6209.5	-4195
Lcp2	-4423.5	-1840.5	2616
Nck1	3641.5	-1946.5	-5117
Pak1	-6577.5	4375.5	-2462
Pak2	-7076.5	-1611.5	-3201
Pak3	-489.5	6017.5	-1097
Plcg1	-2125.5	-5615.5	-6517
Plcg2	-7471.5	7081.5	-2867

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] kableExtra_1.4.0 pkgload_1.4.0    GGally_2.2.1     ggplot2_3.5.1   
##  [5] reshape2_1.4.4   beeswarm_0.4.0   gplots_3.2.0     gtools_3.9.5    
##  [9] tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5  mitch_1.17.4    
## 
## loaded via a namespace (and not attached):
##  [1] gtable_0.3.5       xfun_0.48          bslib_0.8.0        htmlwidgets_1.6.4 
##  [5] caTools_1.18.3     vctrs_0.6.5        tools_4.4.1        bitops_1.0-9      
##  [9] generics_0.1.3     parallel_4.4.1     fansi_1.0.6        highr_0.11        
## [13] pkgconfig_2.0.3    KernSmooth_2.23-24 RColorBrewer_1.1-3 lifecycle_1.0.4   
## [17] compiler_4.4.1     farver_2.1.2       stringr_1.5.1      munsell_0.5.1     
## [21] httpuv_1.6.15      htmltools_0.5.8.1  sass_0.4.9         yaml_2.3.10       
## [25] later_1.3.2        pillar_1.9.0       jquerylib_0.1.4    tidyr_1.3.1       
## [29] MASS_7.3-61        cachem_1.1.0       mime_0.12          ggstats_0.7.0     
## [33] tidyselect_1.2.1   digest_0.6.37      stringi_1.8.4      purrr_1.0.2       
## [37] labeling_0.4.3     fastmap_1.2.0      grid_4.4.1         colorspace_2.1-1  
## [41] cli_3.6.3          magrittr_2.0.3     utf8_1.2.4         withr_3.0.1       
## [45] scales_1.3.0       promises_1.3.0     rmarkdown_2.28     gridExtra_2.3     
## [49] shiny_1.9.1        evaluate_1.0.1     knitr_1.48         viridisLite_0.4.2 
## [53] rlang_1.1.4        Rcpp_1.0.13        xtable_1.8-4       glue_1.8.0        
## [57] xml2_1.3.6         svglite_2.1.3      rstudioapi_0.17.1  jsonlite_1.8.9    
## [61] R6_2.5.1           plyr_1.8.9         systemfonts_1.1.0

END of report