Mitch Report

date generated: 2024-10-24

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
0610007P14Rik	-0.0392645
0610009B22Rik	-0.0028689
0610009E02Rik	-0.2454686
0610009L18Rik	0.9803795
0610009O20Rik	-0.3821166
0610010F05Rik	0.5840653

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	1289
num_genes_in_profile	15245
duplicated_genes_present	0
num_profile_genes_in_sets	6763
num_profile_genes_not_in_sets	8482

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	1289
num_genesets_excluded	389
num_genesets_included	900

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
ENDOSOMAL VACUOLAR PATHWAY	10	1.74e-04	-0.685	1.80e-03
ER PHAGOSOME PATHWAY	19	9.27e-05	-0.518	1.11e-03
GENERATION OF SECOND MESSENGER MOLECULES	12	1.89e-03	-0.518	1.25e-02
INITIAL TRIGGERING OF COMPLEMENT	13	1.50e-03	-0.509	1.07e-02
NCAM1 INTERACTIONS	16	5.23e-04	-0.501	4.40e-03
RAP1 SIGNALLING	15	9.01e-04	-0.495	6.82e-03
RHO GTPASES ACTIVATE KTN1	10	6.99e-03	-0.493	3.53e-02
ANTIGEN PROCESSING CROSS PRESENTATION	72	1.84e-12	-0.480	3.31e-10
RETROGRADE NEUROTROPHIN SIGNALLING	10	9.13e-03	-0.476	4.32e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	19	5.47e-04	-0.458	4.56e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	45	2.36e-07	-0.445	1.25e-05
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	11	1.08e-02	-0.444	4.98e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	11	1.12e-02	-0.442	5.07e-02
RHO GTPASES ACTIVATE NADPH OXIDASES	18	1.22e-03	-0.440	8.89e-03
PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	10	1.69e-02	-0.436	6.71e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION	20	7.45e-04	-0.436	5.87e-03
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	2.05e-02	-0.403	7.76e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	52	5.42e-07	-0.402	2.44e-05
GPVI MEDIATED ACTIVATION CASCADE	29	2.28e-04	-0.395	2.23e-03
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	12	1.79e-02	-0.395	7.02e-02
ACYL CHAIN REMODELLING OF PG	10	3.23e-02	-0.391	1.08e-01
DAP12 INTERACTIONS	31	2.08e-04	-0.385	2.08e-03
POLYMERASE SWITCHING	14	1.30e-02	0.383	5.63e-02
PECAM1 INTERACTIONS	11	2.81e-02	-0.382	9.83e-02
COMPLEMENT CASCADE	26	7.50e-04	-0.382	5.87e-03
ISG15 ANTIVIRAL MECHANISM	27	5.94e-04	-0.382	4.86e-03
PURINE SALVAGE	11	2.98e-02	0.378	1.02e-01
G PROTEIN ACTIVATION	15	1.14e-02	-0.378	5.11e-02
SEMA3A PAK DEPENDENT AXON REPULSION	14	1.45e-02	-0.377	6.10e-02
GLUTATHIONE SYNTHESIS AND RECYCLING	11	3.15e-02	-0.374	1.07e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT	14	1.59e-02	-0.372	6.47e-02
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	14	1.60e-02	-0.372	6.47e-02
G BETA GAMMA SIGNALLING THROUGH CDC42	15	1.38e-02	-0.367	5.90e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	18	7.01e-03	-0.367	3.53e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	42	4.11e-05	-0.366	6.61e-04
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	15	1.52e-02	-0.362	6.32e-02
PLASMA LIPOPROTEIN ASSEMBLY	13	2.55e-02	-0.358	9.07e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	8.66e-03	-0.357	4.15e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	26	1.75e-03	-0.355	1.18e-02
METALLOPROTEASE DUBS	17	1.16e-02	0.354	5.17e-02
ANTIMICROBIAL PEPTIDES	11	4.26e-02	-0.353	1.37e-01
NUCLEAR SIGNALING BY ERBB4	11	4.29e-02	0.353	1.37e-01
POST NMDA RECEPTOR ACTIVATION EVENTS	14	2.26e-02	-0.352	8.25e-02
HS GAG BIOSYNTHESIS	21	5.51e-03	-0.350	2.95e-02
GAP JUNCTION ASSEMBLY	18	1.11e-02	-0.346	5.07e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	54	1.21e-05	-0.344	2.80e-04
PLATELET SENSITIZATION BY LDL	16	1.73e-02	-0.344	6.78e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	2.12e-02	0.344	7.90e-02
NON INTEGRIN MEMBRANE ECM INTERACTIONS	30	1.16e-03	-0.343	8.53e-03
CA DEPENDENT EVENTS	25	3.04e-03	-0.342	1.87e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
ENDOSOMAL VACUOLAR PATHWAY	10	1.74e-04	-0.685000	1.80e-03
ER PHAGOSOME PATHWAY	19	9.27e-05	-0.518000	1.11e-03
GENERATION OF SECOND MESSENGER MOLECULES	12	1.89e-03	-0.518000	1.25e-02
INITIAL TRIGGERING OF COMPLEMENT	13	1.50e-03	-0.509000	1.07e-02
NCAM1 INTERACTIONS	16	5.23e-04	-0.501000	4.40e-03
RAP1 SIGNALLING	15	9.01e-04	-0.495000	6.82e-03
RHO GTPASES ACTIVATE KTN1	10	6.99e-03	-0.493000	3.53e-02
ANTIGEN PROCESSING CROSS PRESENTATION	72	1.84e-12	-0.480000	3.31e-10
RETROGRADE NEUROTROPHIN SIGNALLING	10	9.13e-03	-0.476000	4.32e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	19	5.47e-04	-0.458000	4.56e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	45	2.36e-07	-0.445000	1.25e-05
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	11	1.08e-02	-0.444000	4.98e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	11	1.12e-02	-0.442000	5.07e-02
RHO GTPASES ACTIVATE NADPH OXIDASES	18	1.22e-03	-0.440000	8.89e-03
PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	10	1.69e-02	-0.436000	6.71e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION	20	7.45e-04	-0.436000	5.87e-03
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	2.05e-02	-0.403000	7.76e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	52	5.42e-07	-0.402000	2.44e-05
GPVI MEDIATED ACTIVATION CASCADE	29	2.28e-04	-0.395000	2.23e-03
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	12	1.79e-02	-0.395000	7.02e-02
ACYL CHAIN REMODELLING OF PG	10	3.23e-02	-0.391000	1.08e-01
DAP12 INTERACTIONS	31	2.08e-04	-0.385000	2.08e-03
POLYMERASE SWITCHING	14	1.30e-02	0.383000	5.63e-02
PECAM1 INTERACTIONS	11	2.81e-02	-0.382000	9.83e-02
COMPLEMENT CASCADE	26	7.50e-04	-0.382000	5.87e-03
ISG15 ANTIVIRAL MECHANISM	27	5.94e-04	-0.382000	4.86e-03
PURINE SALVAGE	11	2.98e-02	0.378000	1.02e-01
G PROTEIN ACTIVATION	15	1.14e-02	-0.378000	5.11e-02
SEMA3A PAK DEPENDENT AXON REPULSION	14	1.45e-02	-0.377000	6.10e-02
GLUTATHIONE SYNTHESIS AND RECYCLING	11	3.15e-02	-0.374000	1.07e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT	14	1.59e-02	-0.372000	6.47e-02
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	14	1.60e-02	-0.372000	6.47e-02
G BETA GAMMA SIGNALLING THROUGH CDC42	15	1.38e-02	-0.367000	5.90e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	18	7.01e-03	-0.367000	3.53e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	42	4.11e-05	-0.366000	6.61e-04
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	15	1.52e-02	-0.362000	6.32e-02
PLASMA LIPOPROTEIN ASSEMBLY	13	2.55e-02	-0.358000	9.07e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	8.66e-03	-0.357000	4.15e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	26	1.75e-03	-0.355000	1.18e-02
METALLOPROTEASE DUBS	17	1.16e-02	0.354000	5.17e-02
ANTIMICROBIAL PEPTIDES	11	4.26e-02	-0.353000	1.37e-01
NUCLEAR SIGNALING BY ERBB4	11	4.29e-02	0.353000	1.37e-01
POST NMDA RECEPTOR ACTIVATION EVENTS	14	2.26e-02	-0.352000	8.25e-02
HS GAG BIOSYNTHESIS	21	5.51e-03	-0.350000	2.95e-02
GAP JUNCTION ASSEMBLY	18	1.11e-02	-0.346000	5.07e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	54	1.21e-05	-0.344000	2.80e-04
PLATELET SENSITIZATION BY LDL	16	1.73e-02	-0.344000	6.78e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	2.12e-02	0.344000	7.90e-02
NON INTEGRIN MEMBRANE ECM INTERACTIONS	30	1.16e-03	-0.343000	8.53e-03
CA DEPENDENT EVENTS	25	3.04e-03	-0.342000	1.87e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	19	9.87e-03	-0.342000	4.58e-02
DEGRADATION OF AXIN	52	2.01e-05	-0.342000	3.93e-04
GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME	54	1.39e-05	-0.342000	2.98e-04
RHO GTPASES ACTIVATE PAKS	22	5.72e-03	-0.340000	2.99e-02
CROSSLINKING OF COLLAGEN FIBRILS	18	1.25e-02	-0.340000	5.46e-02
COLLAGEN CHAIN TRIMERIZATION	34	6.05e-04	-0.340000	4.90e-03
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	20	8.62e-03	-0.339000	4.15e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	2.13e-05	-0.338000	3.99e-04
TNFR2 NON CANONICAL NF KB PATHWAY	75	4.51e-07	-0.337000	2.14e-05
CYTOSOLIC SULFONATION OF SMALL MOLECULES	12	4.35e-02	-0.337000	1.38e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	16	2.00e-02	-0.336000	7.65e-02
SHC1 EVENTS IN EGFR SIGNALING	11	5.41e-02	-0.335000	1.59e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	18	1.41e-02	-0.334000	5.95e-02
SIGNALING BY PDGF	50	4.36e-05	-0.334000	6.66e-04
ERBB2 REGULATES CELL MOTILITY	12	4.59e-02	-0.333000	1.43e-01
LDL CLEARANCE	15	2.59e-02	-0.332000	9.15e-02
UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A	49	6.46e-05	-0.330000	9.03e-04
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	27	3.09e-03	-0.329000	1.88e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	68	2.81e-06	-0.329000	9.37e-05
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	30	1.84e-03	-0.329000	1.23e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	16	2.32e-02	-0.328000	8.38e-02
REGULATION OF ENDOGENOUS RETROELEMENTS	28	2.73e-03	0.327000	1.73e-02
RHOH GTPASE CYCLE	31	1.67e-03	-0.326000	1.13e-02
NUCLEAR EVENTS MEDIATED BY NFE2L2	53	4.19e-05	-0.325000	6.61e-04
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	23	7.10e-03	0.324000	3.55e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	17	2.08e-02	-0.324000	7.83e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	50	7.87e-05	-0.323000	1.01e-03
HEDGEHOG LIGAND BIOGENESIS	56	3.06e-05	-0.322000	5.30e-04
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	7.82e-02	-0.322000	2.05e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	4.60e-02	-0.320000	1.43e-01
METABOLISM OF POLYAMINES	54	4.98e-05	-0.319000	7.48e-04
CELLULAR RESPONSE TO HYPOXIA	65	8.99e-06	-0.319000	2.31e-04
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	11	7.19e-02	-0.313000	1.93e-01
DISSOLUTION OF FIBRIN CLOT	10	8.66e-02	-0.313000	2.21e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	1.21e-06	-0.312000	4.75e-05
SYNDECAN INTERACTIONS	14	4.42e-02	-0.311000	1.40e-01
ACTIVATION OF APC C AND APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	72	5.35e-06	-0.310000	1.50e-04
RHO GTPASES ACTIVATE IQGAPS	26	6.25e-03	-0.310000	3.20e-02
METABOLISM OF FAT SOLUBLE VITAMINS	31	2.91e-03	-0.309000	1.81e-02
DEGRADATION OF DVL	53	1.00e-04	-0.309000	1.17e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	6.92e-06	-0.309000	1.85e-04
STABILIZATION OF P53	52	1.20e-04	-0.308000	1.32e-03
TRIGLYCERIDE METABOLISM	12	6.54e-02	-0.307000	1.83e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	1.12e-04	-0.307000	1.26e-03
SYNTHESIS OF BILE ACIDS AND BILE SALTS	24	9.36e-03	-0.306000	4.41e-02
TCR SIGNALING	90	6.46e-07	-0.304000	2.70e-05
ECM PROTEOGLYCANS	35	1.96e-03	-0.303000	1.29e-02
TRANSCRIPTIONAL REGULATION BY RUNX2	60	5.38e-05	-0.302000	7.69e-04
RECYCLING PATHWAY OF L1	33	2.74e-03	-0.301000	1.73e-02
GAB1 SIGNALOSOME	15	4.37e-02	-0.301000	1.39e-01
ACYL CHAIN REMODELLING OF PS	14	5.15e-02	-0.301000	1.53e-01
ACTIVATION OF NF KAPPAB IN B CELLS	59	6.96e-05	-0.300000	9.49e-04
REGULATION OF RAS BY GAPS	63	4.05e-05	-0.299000	6.61e-04
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	5.50e-03	-0.298000	2.95e-02
ACYL CHAIN REMODELLING OF PE	15	4.66e-02	-0.297000	1.44e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	56	1.32e-04	-0.295000	1.44e-03
CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	69	2.26e-05	-0.295000	4.16e-04
G PROTEIN BETA GAMMA SIGNALLING	27	8.05e-03	-0.295000	3.96e-02
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	22	1.68e-02	-0.294000	6.70e-02
LAMININ INTERACTIONS	15	4.88e-02	-0.294000	1.48e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	7.82e-02	-0.294000	2.05e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	1.50e-02	-0.293000	6.26e-02
PYROPTOSIS	16	4.35e-02	-0.292000	1.38e-01
UBIQUINOL BIOSYNTHESIS	11	9.42e-02	-0.292000	2.34e-01
INTRINSIC PATHWAY FOR APOPTOSIS	34	3.34e-03	-0.291000	1.99e-02
COLLAGEN FORMATION	65	5.16e-05	-0.290000	7.61e-04
DOWNSTREAM TCR SIGNALING	78	1.01e-05	-0.289000	2.52e-04
CD28 DEPENDENT VAV1 PATHWAY	11	9.70e-02	-0.289000	2.40e-01
MISMATCH REPAIR MMR DIRECTED BY MSH2 MSH3 MUTSBETA	10	1.16e-01	0.287000	2.78e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	16	4.78e-02	-0.286000	1.47e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	90	3.00e-06	-0.285000	9.65e-05
SIGNAL AMPLIFICATION	26	1.20e-02	-0.285000	5.34e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD4	14	6.54e-02	-0.284000	1.83e-01
GPER1 SIGNALING	22	2.12e-02	-0.284000	7.90e-02
TRAF6 MEDIATED NF KB ACTIVATION	13	7.65e-02	-0.284000	2.02e-01
REGULATION OF FZD BY UBIQUITINATION	13	7.73e-02	0.283000	2.03e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	14	6.77e-02	-0.282000	1.86e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	81	1.18e-05	-0.282000	2.79e-04
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	59	1.84e-04	-0.282000	1.88e-03
METAL ION SLC TRANSPORTERS	17	4.55e-02	-0.280000	1.43e-01
IRAK1 RECRUITS IKK COMPLEX	14	7.12e-02	0.279000	1.92e-01
PCP CE PATHWAY	82	1.34e-05	-0.278000	2.98e-04
LAGGING STRAND SYNTHESIS	20	3.20e-02	0.277000	1.07e-01
BILE ACID AND BILE SALT METABOLISM	28	1.12e-02	-0.277000	5.09e-02
COSTIMULATION BY THE CD28 FAMILY	52	5.62e-04	-0.277000	4.64e-03
AQUAPORIN MEDIATED TRANSPORT	25	1.71e-02	-0.276000	6.75e-02
HDR THROUGH MMEJ ALT NHEJ	12	9.97e-02	-0.274000	2.46e-01
G PROTEIN MEDIATED EVENTS	36	4.45e-03	-0.274000	2.52e-02
INTERLEUKIN 1 FAMILY SIGNALING	105	1.32e-06	-0.273000	4.95e-05
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	1.17e-01	0.273000	2.78e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	53	6.11e-04	-0.272000	4.91e-03
INTERLEUKIN 6 FAMILY SIGNALING	16	6.05e-02	-0.271000	1.71e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	1.39e-01	-0.271000	3.10e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	14	7.99e-02	-0.270000	2.08e-01
COHESIN LOADING ONTO CHROMATIN	10	1.40e-01	0.270000	3.12e-01
MHC CLASS II ANTIGEN PRESENTATION	98	4.02e-06	-0.270000	1.20e-04
G ALPHA Z SIGNALLING EVENTS	27	1.56e-02	-0.269000	6.45e-02
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	24	2.26e-02	-0.269000	8.25e-02
KEAP1 NFE2L2 PATHWAY	73	7.30e-05	-0.269000	9.81e-04
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	61	2.99e-04	-0.268000	2.87e-03
FORMATION OF WDR5 CONTAINING HISTONE MODIFYING COMPLEXES	36	5.59e-03	0.267000	2.98e-02
FCERI MEDIATED NF KB ACTIVATION	70	1.16e-04	-0.267000	1.29e-03
CONDENSATION OF PROPHASE CHROMOSOMES	12	1.11e-01	-0.266000	2.66e-01
OTHER INTERLEUKIN SIGNALING	14	8.50e-02	-0.266000	2.19e-01
HS GAG DEGRADATION	19	4.58e-02	-0.265000	1.43e-01
COMPLEX III ASSEMBLY	17	5.92e-02	0.264000	1.70e-01
AGGREPHAGY	28	1.58e-02	-0.263000	6.47e-02
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	14	8.80e-02	-0.263000	2.24e-01
COLLAGEN DEGRADATION	39	4.51e-03	-0.263000	2.53e-02
SEMA4D IN SEMAPHORIN SIGNALING	15	8.07e-02	-0.261000	2.09e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	83	4.33e-05	-0.260000	6.66e-04
TELOMERE C STRAND SYNTHESIS INITIATION	11	1.38e-01	0.258000	3.10e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	17	6.56e-02	-0.258000	1.83e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	40	4.95e-03	-0.257000	2.73e-02
ACTIVATION OF BH3 ONLY PROTEINS	17	6.75e-02	-0.256000	1.86e-01
CYTOPROTECTION BY HMOX1	44	3.30e-03	0.256000	1.98e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	10	1.64e-01	0.254000	3.42e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	24	3.17e-02	0.253000	1.07e-01
TRP CHANNELS	15	8.97e-02	-0.253000	2.25e-01
INTERLEUKIN 1 SIGNALING	96	1.87e-05	-0.253000	3.73e-04
ORC1 REMOVAL FROM CHROMATIN	65	4.60e-04	-0.251000	4.03e-03
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	14	1.04e-01	0.251000	2.54e-01
INTEGRIN CELL SURFACE INTERACTIONS	65	4.87e-04	-0.250000	4.14e-03
SUMOYLATION OF TRANSCRIPTION FACTORS	13	1.20e-01	0.249000	2.83e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	1.74e-01	0.248000	3.53e-01
RHO GTPASE EFFECTORS	217	4.04e-10	-0.247000	3.64e-08
PLATELET AGGREGATION PLUG FORMATION	30	1.99e-02	-0.246000	7.64e-02
MAPK6 MAPK4 SIGNALING	70	4.11e-04	-0.244000	3.73e-03
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	31	1.89e-02	0.244000	7.34e-02
CD209 DC SIGN SIGNALING	16	9.20e-02	-0.243000	2.30e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	12	1.46e-01	0.243000	3.22e-01
CS DS DEGRADATION	11	1.64e-01	-0.243000	3.42e-01
ARACHIDONIC ACID METABOLISM	33	1.59e-02	-0.243000	6.47e-02
SIGNALING BY INTERLEUKINS	222	5.14e-10	-0.242000	4.21e-08
CLEC7A DECTIN 1 SIGNALING	88	8.57e-05	-0.242000	1.05e-03
INTEGRIN SIGNALING	26	3.28e-02	-0.242000	1.08e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	1.07e-04	-0.242000	1.22e-03
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	41	7.54e-03	-0.241000	3.73e-02
DOWNSTREAM SIGNAL TRANSDUCTION	26	3.38e-02	-0.240000	1.11e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	5.67e-02	-0.240000	1.64e-01
C TYPE LECTIN RECEPTORS CLRS	104	2.35e-05	-0.240000	4.23e-04
HEDGEHOG ON STATE	75	3.27e-04	-0.240000	3.07e-03
ERK MAPK TARGETS	19	7.14e-02	-0.239000	1.92e-01
GAP JUNCTION TRAFFICKING AND REGULATION	30	2.36e-02	-0.239000	8.50e-02
MAP2K AND MAPK ACTIVATION	36	1.32e-02	-0.239000	5.67e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	17	8.86e-02	0.239000	2.24e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	89	1.05e-04	-0.238000	1.22e-03
FCGR ACTIVATION	11	1.72e-01	-0.238000	3.52e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	66	8.91e-04	-0.237000	6.80e-03
CHEMOKINE RECEPTORS BIND CHEMOKINES	20	6.72e-02	-0.236000	1.86e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	73	4.87e-04	-0.236000	4.14e-03
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	42	8.43e-03	-0.235000	4.12e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	68	8.38e-04	-0.234000	6.45e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	10	2.00e-01	-0.234000	3.88e-01
HEDGEHOG OFF STATE	100	5.30e-05	-0.234000	7.69e-04
SIGNALING BY NTRK1 TRKA	62	1.49e-03	-0.233000	1.07e-02
PLATELET HOMEOSTASIS	64	1.26e-03	-0.233000	9.18e-03
BETA CATENIN INDEPENDENT WNT SIGNALING	112	2.08e-05	-0.233000	3.99e-04
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	10	2.03e-01	-0.233000	3.90e-01
RHO GTPASES ACTIVATE PKNS	21	6.53e-02	-0.232000	1.83e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	33	2.12e-02	-0.232000	7.90e-02
NICOTINAMIDE SALVAGING	15	1.23e-01	-0.230000	2.86e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	24	5.09e-02	-0.230000	1.52e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	13	1.51e-01	-0.230000	3.28e-01
INTRA GOLGI TRAFFIC	33	2.23e-02	-0.230000	8.23e-02
SYNTHESIS OF PE	10	2.08e-01	-0.230000	3.98e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	214	7.47e-09	-0.230000	5.60e-07
SEMAPHORIN INTERACTIONS	50	5.14e-03	-0.229000	2.82e-02
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	74	6.80e-04	-0.229000	5.41e-03
ACTIVATION OF SMO	10	2.11e-01	0.228000	4.02e-01
GLUCONEOGENESIS	19	8.51e-02	-0.228000	2.19e-01
INTERLEUKIN 20 FAMILY SIGNALING	11	1.90e-01	-0.228000	3.75e-01
KINESINS	47	6.85e-03	-0.228000	3.48e-02
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	1.72e-01	-0.228000	3.52e-01
TRANSCRIPTIONAL REGULATION BY E2F6	23	6.01e-02	0.227000	1.71e-01
COMPLEX IV ASSEMBLY	38	1.59e-02	0.226000	6.47e-02
SIGNALING BY THE B CELL RECEPTOR BCR	94	1.57e-04	-0.226000	1.68e-03
GLUCAGON TYPE LIGAND RECEPTORS	17	1.10e-01	-0.224000	2.65e-01
BIOTIN TRANSPORT AND METABOLISM	11	2.01e-01	-0.223000	3.89e-01
OPIOID SIGNALLING	59	3.10e-03	-0.223000	1.88e-02
INTERACTION BETWEEN L1 AND ANKYRINS	10	2.23e-01	-0.222000	4.15e-01
OTHER SEMAPHORIN INTERACTIONS	14	1.51e-01	-0.222000	3.28e-01
REGULATION OF BACH1 ACTIVITY	10	2.25e-01	0.221000	4.16e-01
RHOBTB1 GTPASE CYCLE	22	7.24e-02	0.221000	1.94e-01
G1 S DNA DAMAGE CHECKPOINTS	61	2.91e-03	-0.221000	1.81e-02
INTERLEUKIN 2 FAMILY SIGNALING	26	5.25e-02	-0.220000	1.55e-01
SIGNALING BY SCF KIT	33	2.92e-02	-0.219000	1.02e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	1.41e-01	-0.219000	3.14e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	4.67e-04	-0.218000	4.04e-03
NEUTROPHIL DEGRANULATION	386	2.30e-13	-0.218000	5.16e-11
ERKS ARE INACTIVATED	13	1.74e-01	-0.218000	3.53e-01
RHOV GTPASE CYCLE	34	2.80e-02	-0.218000	9.83e-02
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	110	8.09e-05	-0.218000	1.01e-03
EXTRACELLULAR MATRIX ORGANIZATION	191	2.23e-07	-0.218000	1.25e-05
O LINKED GLYCOSYLATION OF MUCINS	30	3.92e-02	-0.218000	1.27e-01
UB SPECIFIC PROCESSING PROTEASES	151	4.14e-06	-0.217000	1.20e-04
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	21	8.61e-02	-0.216000	2.20e-01
INNATE IMMUNE SYSTEM	712	1.65e-22	-0.216000	7.42e-20
SIGNALING BY VEGF	98	2.25e-04	-0.216000	2.23e-03
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	36	2.58e-02	-0.215000	9.15e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.80e-01	-0.215000	3.63e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	60	4.16e-03	-0.214000	2.42e-02
PTEN REGULATION	95	3.24e-04	-0.214000	3.07e-03
DEGRADATION OF THE EXTRACELLULAR MATRIX	79	1.05e-03	-0.213000	7.80e-03
SIGNALING BY HEDGEHOG	125	3.85e-05	-0.213000	6.42e-04
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	26	5.99e-02	0.213000	1.71e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	34	3.16e-02	-0.213000	1.07e-01
REGULATION OF NF KAPPA B SIGNALING	16	1.40e-01	-0.213000	3.12e-01
FORMATION OF THE CORNIFIED ENVELOPE	17	1.29e-01	-0.213000	2.95e-01
KERATINIZATION	17	1.29e-01	-0.213000	2.95e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	20	1.00e-01	-0.212000	2.46e-01
GOLGI TO ER RETROGRADE TRANSPORT	116	8.65e-05	-0.211000	1.05e-03
RMTS METHYLATE HISTONE ARGININES	25	6.78e-02	-0.211000	1.86e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	75	1.59e-03	-0.211000	1.09e-02
UCH PROTEINASES	77	1.58e-03	-0.208000	1.09e-02
DNA REPLICATION PRE INITIATION	97	4.00e-04	-0.208000	3.68e-03
SMOOTH MUSCLE CONTRACTION	29	5.24e-02	-0.208000	1.55e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	169	3.18e-06	-0.208000	9.88e-05
EPHB MEDIATED FORWARD SIGNALING	35	3.35e-02	-0.208000	1.10e-01
FANCONI ANEMIA PATHWAY	33	4.00e-02	0.207000	1.29e-01
ADAPTIVE IMMUNE SYSTEM	566	7.14e-17	-0.206000	2.14e-14
RESPIRATORY ELECTRON TRANSPORT	124	7.71e-05	0.206000	1.01e-03
CHONDROITIN SULFATE BIOSYNTHESIS	16	1.55e-01	-0.205000	3.35e-01
REGULATION OF KIT SIGNALING	12	2.18e-01	-0.205000	4.11e-01
PLASMA LIPOPROTEIN CLEARANCE	28	6.04e-02	-0.205000	1.71e-01
SIGNALING BY CSF3 G CSF	19	1.23e-01	-0.205000	2.86e-01
IMMUNE SYSTEM	1247	3.05e-33	-0.204000	2.75e-30
ER TO GOLGI ANTEROGRADE TRANSPORT	139	3.44e-05	-0.204000	5.84e-04
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	164	6.99e-06	-0.204000	1.85e-04
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	2.65e-01	-0.203000	4.62e-01
DAP12 SIGNALING	21	1.07e-01	-0.203000	2.59e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	81	1.59e-03	-0.203000	1.09e-02
TRANSCRIPTIONAL REGULATION BY RUNX3	76	2.33e-03	-0.202000	1.51e-02
RECEPTOR MEDIATED MITOPHAGY	11	2.48e-01	0.201000	4.42e-01
RUNX3 REGULATES NOTCH SIGNALING	10	2.71e-01	0.201000	4.67e-01
CD28 CO STIMULATION	31	5.38e-02	-0.200000	1.59e-01
LYSOSOME VESICLE BIOGENESIS	30	5.83e-02	-0.200000	1.68e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK IKBKE	17	1.55e-01	-0.199000	3.35e-01
VISUAL PHOTOTRANSDUCTION	51	1.41e-02	-0.199000	5.95e-02
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	17	1.57e-01	0.198000	3.36e-01
SIGNALING BY NTRKS	73	3.69e-03	-0.197000	2.19e-02
RNA POLYMERASE III TRANSCRIPTION	34	4.82e-02	0.196000	1.48e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	11	2.64e-01	-0.195000	4.61e-01
NUCLEOTIDE SALVAGE	19	1.43e-01	0.194000	3.17e-01
INACTIVATION OF CSF3 G CSF SIGNALING	15	1.93e-01	-0.194000	3.80e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	224	6.60e-07	-0.193000	2.70e-05
MAPK FAMILY SIGNALING CASCADES	258	1.01e-07	-0.193000	6.52e-06
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	58	1.11e-02	-0.193000	5.07e-02
TRANSLESION SYNTHESIS BY POLK	17	1.69e-01	0.193000	3.50e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	18	1.57e-01	-0.193000	3.36e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	360	3.98e-10	-0.193000	3.64e-08
EPIGENETIC REGULATION OF GENE EXPRESSION	103	7.60e-04	0.192000	5.90e-03
HEMOSTASIS	424	1.46e-11	-0.192000	2.19e-09
MET ACTIVATES PTK2 SIGNALING	18	1.59e-01	-0.192000	3.36e-01
SYNAPTIC ADHESION LIKE MOLECULES	15	1.99e-01	-0.192000	3.88e-01
EXTENSION OF TELOMERES	43	2.99e-02	0.191000	1.02e-01
G ALPHA I SIGNALLING EVENTS	129	1.94e-04	-0.190000	1.96e-03
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	14	2.18e-01	-0.190000	4.11e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	11	2.76e-01	-0.190000	4.72e-01
L1CAM INTERACTIONS	63	9.45e-03	-0.189000	4.43e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	10	3.01e-01	-0.189000	5.01e-01
COMPLEX I BIOGENESIS	58	1.30e-02	0.189000	5.63e-02
CRMPS IN SEMA3A SIGNALING	14	2.22e-01	-0.189000	4.15e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	23	1.19e-01	-0.188000	2.81e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	51	2.03e-02	-0.188000	7.71e-02
GLYCOSPHINGOLIPID BIOSYNTHESIS	14	2.25e-01	-0.187000	4.16e-01
SIGNALING BY BMP	23	1.21e-01	-0.187000	2.84e-01
CLATHRIN MEDIATED ENDOCYTOSIS	120	4.42e-04	-0.186000	3.96e-03
VEGFR2 MEDIATED CELL PROLIFERATION	12	2.66e-01	-0.185000	4.62e-01
NUCLEAR ENVELOPE NE REASSEMBLY	61	1.25e-02	-0.185000	5.46e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	16	2.03e-01	-0.184000	3.90e-01
METABOLISM OF FOLATE AND PTERINES	17	1.89e-01	0.184000	3.74e-01
TRANS GOLGI NETWORK VESICLE BUDDING	66	9.82e-03	-0.184000	4.58e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM	11	2.91e-01	0.184000	4.90e-01
TELOMERE MAINTENANCE	47	2.99e-02	0.183000	1.02e-01
SIGNALING BY ACTIVIN	14	2.36e-01	-0.183000	4.28e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	20	1.57e-01	-0.183000	3.36e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	18	1.80e-01	0.182000	3.63e-01
PHOSPHORYLATION OF THE APC C	19	1.69e-01	-0.182000	3.50e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	14	2.40e-01	0.181000	4.32e-01
SEPARATION OF SISTER CHROMATIDS	165	6.52e-05	-0.180000	9.03e-04
MITOTIC METAPHASE AND ANAPHASE	202	1.09e-05	-0.180000	2.65e-04
EPHRIN SIGNALING	18	1.89e-01	-0.179000	3.74e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	14	2.48e-01	0.178000	4.42e-01
GABA B RECEPTOR ACTIVATION	33	7.65e-02	-0.178000	2.02e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	86	4.44e-03	-0.178000	2.52e-02
NEGATIVE REGULATION OF MAPK PATHWAY	41	4.95e-02	-0.177000	1.50e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	19	1.81e-01	-0.177000	3.63e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	17	2.08e-01	-0.176000	3.98e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	51	2.95e-02	-0.176000	1.02e-01
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT	202	1.65e-05	0.176000	3.38e-04
SIGNALING BY RECEPTOR TYROSINE KINASES	359	1.12e-08	-0.176000	7.76e-07
INTERFERON ALPHA BETA SIGNALING	19	1.85e-01	-0.176000	3.68e-01
REPRODUCTION	11	3.13e-01	0.176000	5.12e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	22	1.55e-01	-0.175000	3.35e-01
FC EPSILON RECEPTOR FCERI SIGNALING	110	1.55e-03	-0.175000	1.09e-02
SENSORY PERCEPTION	56	2.39e-02	-0.175000	8.54e-02
MET PROMOTES CELL MOTILITY	28	1.12e-01	-0.173000	2.69e-01
N GLYCAN ANTENNAE ELONGATION	13	2.80e-01	-0.173000	4.78e-01
INWARDLY RECTIFYING K CHANNELS	25	1.37e-01	-0.172000	3.10e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	25	1.38e-01	-0.171000	3.10e-01
RAC1 GTPASE CYCLE	162	1.74e-04	-0.171000	1.80e-03
RHOU GTPASE CYCLE	38	6.80e-02	-0.171000	1.86e-01
APOPTOSIS	89	5.45e-03	-0.171000	2.95e-02
RAC2 GTPASE CYCLE	80	8.54e-03	-0.170000	4.15e-02
DNA STRAND ELONGATION	24	1.49e-01	0.170000	3.26e-01
RHOF GTPASE CYCLE	39	6.79e-02	-0.169000	1.86e-01
GLYCOSAMINOGLYCAN METABOLISM	98	3.89e-03	-0.169000	2.27e-02
PROGRAMMED CELL DEATH	117	1.65e-03	-0.169000	1.13e-02
TOLL LIKE RECEPTOR 4 TLR4 CASCADE	112	2.08e-03	-0.169000	1.36e-02
PEPTIDE LIGAND BINDING RECEPTORS	57	2.98e-02	-0.166000	1.02e-01
GLYCOGEN METABOLISM	17	2.35e-01	-0.166000	4.28e-01
REDUCTION OF CYTOSOLIC CA LEVELS	12	3.20e-01	-0.166000	5.18e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	10	3.65e-01	0.166000	5.71e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	27	1.37e-01	0.165000	3.10e-01
SHC1 EVENTS IN ERBB4 SIGNALING	10	3.67e-01	-0.165000	5.71e-01
BRANCHED CHAIN AMINO ACID CATABOLISM	20	2.04e-01	0.164000	3.92e-01
TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION	36	8.87e-02	-0.164000	2.24e-01
PRC2 METHYLATES HISTONES AND DNA	15	2.72e-01	0.164000	4.68e-01
VESICLE MEDIATED TRANSPORT	522	2.40e-10	-0.163000	2.70e-08
INTERLEUKIN 7 SIGNALING	12	3.32e-01	-0.162000	5.34e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	28	1.39e-01	-0.162000	3.10e-01
ASPARAGINE N LINKED GLYCOSYLATION	241	1.61e-05	-0.162000	3.38e-04
METHYLATION	13	3.14e-01	-0.161000	5.12e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	99	5.66e-03	-0.161000	2.99e-02
COPII MEDIATED VESICLE TRANSPORT	66	2.38e-02	-0.161000	8.54e-02
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	14	2.99e-01	-0.160000	5.01e-01
REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE	32	1.17e-01	-0.160000	2.78e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	90	8.91e-03	-0.160000	4.24e-02
ACYL CHAIN REMODELLING OF PC	17	2.56e-01	-0.159000	4.51e-01
CARGO CONCENTRATION IN THE ER	29	1.38e-01	-0.159000	3.10e-01
REGULATION OF PTEN GENE TRANSCRIPTION	27	1.53e-01	-0.159000	3.33e-01
MITOTIC G2 G2 M PHASES	171	3.51e-04	-0.159000	3.26e-03
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	51	5.05e-02	0.158000	1.52e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	28	1.48e-01	-0.158000	3.25e-01
CELL CELL COMMUNICATION	70	2.25e-02	-0.158000	8.25e-02
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	564	1.98e-10	-0.158000	2.54e-08
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	84	1.31e-02	-0.157000	5.63e-02
TOLL LIKE RECEPTOR CASCADES	138	1.51e-03	-0.157000	1.07e-02
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	314	2.10e-06	-0.156000	7.28e-05
RHO GTPASES ACTIVATE FORMINS	116	3.81e-03	-0.156000	2.24e-02
CITRIC ACID CYCLE TCA CYCLE	33	1.23e-01	0.155000	2.86e-01
DEPOLYMERIZATION OF THE NUCLEAR LAMINA	11	3.73e-01	-0.155000	5.77e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	44	7.58e-02	-0.155000	2.01e-01
SIGNALING BY HIPPO	20	2.31e-01	-0.155000	4.25e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	107	5.79e-03	-0.155000	2.99e-02
SUMOYLATION OF TRANSCRIPTION COFACTORS	37	1.04e-01	0.154000	2.54e-01
ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS	20	2.33e-01	-0.154000	4.27e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	14	3.18e-01	0.154000	5.17e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	82	1.61e-02	-0.154000	6.48e-02
REGULATION OF PYRUVATE METABOLISM	32	1.32e-01	0.154000	3.02e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	22	2.16e-01	0.152000	4.09e-01
EUKARYOTIC TRANSLATION INITIATION	112	5.48e-03	-0.152000	2.95e-02
REGULATION OF TBK1 IKK IKBKE MEDIATED ACTIVATION OF IRF3 IRF7	14	3.25e-01	-0.152000	5.25e-01
CTLA4 INHIBITORY SIGNALING	20	2.40e-01	-0.152000	4.32e-01
IRS MEDIATED SIGNALLING	28	1.65e-01	-0.152000	3.44e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	11	3.84e-01	0.152000	5.88e-01
SHC MEDIATED CASCADE FGFR1	11	3.85e-01	-0.151000	5.88e-01
SHC1 EVENTS IN ERBB2 SIGNALING	13	3.46e-01	-0.151000	5.50e-01
BETA CATENIN PHOSPHORYLATION CASCADE	17	2.82e-01	-0.151000	4.80e-01
INSULIN RECEPTOR RECYCLING	24	2.02e-01	-0.151000	3.90e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	29	1.62e-01	0.150000	3.41e-01
NERVOUS SYSTEM DEVELOPMENT	235	8.02e-05	-0.150000	1.01e-03
DEADENYLATION OF MRNA	22	2.25e-01	-0.149000	4.16e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	19	2.61e-01	-0.149000	4.58e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	23	2.18e-01	-0.148000	4.11e-01
RA BIOSYNTHESIS PATHWAY	15	3.20e-01	-0.148000	5.18e-01
ELASTIC FIBRE FORMATION	36	1.24e-01	-0.148000	2.86e-01
METABOLISM OF CARBOHYDRATES	219	1.60e-04	-0.148000	1.69e-03
PHASE II CONJUGATION OF COMPOUNDS	69	3.34e-02	-0.148000	1.10e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	3.06e-01	0.148000	5.06e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	32	1.49e-01	0.148000	3.25e-01
PI 3K CASCADE FGFR1	12	3.78e-01	-0.147000	5.82e-01
OVARIAN TUMOR DOMAIN PROTEASES	31	1.59e-01	-0.146000	3.36e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	126	4.82e-03	-0.146000	2.68e-02
G2 M CHECKPOINTS	121	5.74e-03	-0.146000	2.99e-02
DNA REPLICATION	121	5.84e-03	-0.145000	3.00e-02
CHOLESTEROL BIOSYNTHESIS	26	2.00e-01	0.145000	3.88e-01
EPH EPHRIN SIGNALING	57	6.05e-02	-0.144000	1.71e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	30	1.73e-01	-0.144000	3.53e-01
M PHASE	312	1.37e-05	-0.144000	2.98e-04
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	49	8.25e-02	-0.143000	2.13e-01
HYALURONAN UPTAKE AND DEGRADATION	11	4.11e-01	-0.143000	6.10e-01
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	4.33e-01	0.143000	6.38e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	29	1.84e-01	-0.143000	3.68e-01
REGULATION OF CDH11 EXPRESSION AND FUNCTION	11	4.13e-01	0.143000	6.13e-01
SELECTIVE AUTOPHAGY	63	5.08e-02	-0.142000	1.52e-01
NICOTINATE METABOLISM	25	2.21e-01	-0.141000	4.15e-01
MITOCHONDRIAL BIOGENESIS	10	4.39e-01	0.141000	6.44e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	10	4.39e-01	0.141000	6.44e-01
SHC MEDIATED CASCADE FGFR2	12	3.99e-01	-0.141000	5.97e-01
GPCR LIGAND BINDING	139	4.32e-03	-0.140000	2.49e-02
REGULATED NECROSIS	45	1.06e-01	-0.139000	2.57e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	15	3.50e-01	-0.139000	5.54e-01
GLUCOSE METABOLISM	64	5.46e-02	-0.139000	1.60e-01
PI3K EVENTS IN ERBB2 SIGNALING	13	3.86e-01	-0.139000	5.89e-01
G1 S TRANSITION	101	1.61e-02	-0.139000	6.48e-02
DEUBIQUITINATION	216	4.62e-04	-0.139000	4.03e-03
CELLULAR HEXOSE TRANSPORT	13	3.88e-01	-0.138000	5.89e-01
TRANSPORT OF SMALL MOLECULES	500	1.39e-07	-0.138000	8.36e-06
APC CDC20 MEDIATED DEGRADATION OF NEK2A	26	2.23e-01	-0.138000	4.15e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	2.64e-01	-0.138000	4.61e-01
SIALIC ACID METABOLISM	25	2.34e-01	-0.137000	4.28e-01
PI 3K CASCADE FGFR2	13	3.91e-01	-0.137000	5.90e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	11	4.31e-01	-0.137000	6.37e-01
CHAPERONIN MEDIATED PROTEIN FOLDING	31	1.87e-01	-0.137000	3.72e-01
RHOJ GTPASE CYCLE	15	3.60e-01	0.137000	5.66e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	3.94e-01	-0.137000	5.94e-01
GRB2 EVENTS IN ERBB2 SIGNALING	10	4.56e-01	-0.136000	6.58e-01
PENTOSE PHOSPHATE PATHWAY	14	3.79e-01	-0.136000	5.83e-01
REGULATION OF SIGNALING BY CBL	21	2.82e-01	-0.136000	4.80e-01
MISMATCH REPAIR	14	3.81e-01	0.135000	5.84e-01
REGULATED PROTEOLYSIS OF P75NTR	10	4.59e-01	0.135000	6.60e-01
METABOLISM OF STEROID HORMONES	15	3.66e-01	0.135000	5.71e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	2.53e-01	0.135000	4.49e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	25	2.44e-01	-0.135000	4.37e-01
SIGNALING BY MET	61	6.93e-02	-0.135000	1.88e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	15	3.70e-01	0.134000	5.74e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	29	2.13e-01	-0.134000	4.04e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	86	3.27e-02	-0.133000	1.08e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	145	5.73e-03	-0.133000	2.99e-02
PROLONGED ERK ACTIVATION EVENTS	13	4.09e-01	-0.132000	6.09e-01
PKMTS METHYLATE HISTONE LYSINES	36	1.70e-01	0.132000	3.50e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND	46	1.24e-01	-0.131000	2.86e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	14	3.96e-01	-0.131000	5.95e-01
GABA RECEPTOR ACTIVATION	37	1.71e-01	-0.130000	3.52e-01
PEPTIDE HORMONE METABOLISM	34	1.94e-01	-0.129000	3.80e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	30	2.23e-01	0.129000	4.15e-01
VLDLR INTERNALISATION AND DEGRADATION	15	3.88e-01	-0.129000	5.89e-01
SIGNALING BY GPCR	323	7.64e-05	-0.128000	1.01e-03
SIGNALING BY INSULIN RECEPTOR	56	9.71e-02	-0.128000	2.40e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	12	4.43e-01	-0.128000	6.47e-01
SIGNALLING TO ERKS	25	2.69e-01	-0.128000	4.66e-01
DEVELOPMENTAL BIOLOGY	316	9.87e-05	-0.128000	1.17e-03
MACROAUTOPHAGY	119	1.63e-02	-0.128000	6.54e-02
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	12	4.44e-01	0.128000	6.47e-01
HDMS DEMETHYLATE HISTONES	21	3.14e-01	0.127000	5.12e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	3.05e-01	0.126000	5.06e-01
RAB REGULATION OF TRAFFICKING	109	2.32e-02	-0.126000	8.38e-02
ENDOGENOUS STEROLS	17	3.69e-01	-0.126000	5.73e-01
DNA DOUBLE STRAND BREAK RESPONSE	41	1.64e-01	0.126000	3.42e-01
G ALPHA Q SIGNALLING EVENTS	116	1.94e-02	-0.126000	7.50e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES	187	3.19e-03	-0.125000	1.92e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	30	2.36e-01	-0.125000	4.28e-01
RHO GTPASE CYCLE	390	2.46e-05	-0.125000	4.35e-04
MITOTIC TELOPHASE CYTOKINESIS	13	4.36e-01	0.125000	6.41e-01
METABOLISM OF VITAMINS AND COFACTORS	157	7.13e-03	-0.125000	3.55e-02
PROCESSING AND ACTIVATION OF SUMO	10	4.98e-01	-0.124000	6.87e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	28	2.59e-01	0.123000	4.56e-01
PI METABOLISM	72	7.12e-02	-0.123000	1.92e-01
SIGNALLING TO RAS	12	4.61e-01	-0.123000	6.60e-01
JOSEPHIN DOMAIN DUBS	10	5.01e-01	0.123000	6.90e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	28	2.61e-01	-0.123000	4.58e-01
HEME DEGRADATION	10	5.03e-01	-0.122000	6.91e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	39	1.87e-01	-0.122000	3.72e-01
RAC3 GTPASE CYCLE	82	5.65e-02	-0.122000	1.64e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	28	2.66e-01	-0.122000	4.62e-01
MITOTIC PROPHASE	67	8.58e-02	-0.121000	2.20e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	89	4.85e-02	-0.121000	1.48e-01
CDC42 GTPASE CYCLE	90	4.84e-02	-0.121000	1.48e-01
AURKA ACTIVATION BY TPX2	68	8.93e-02	-0.119000	2.25e-01
SYNTHESIS OF PA	25	3.03e-01	-0.119000	5.03e-01
GAP JUNCTION DEGRADATION	11	4.94e-01	-0.119000	6.87e-01
SHC MEDIATED CASCADE FGFR4	11	4.96e-01	-0.119000	6.87e-01
FCERI MEDIATED MAPK ACTIVATION	26	2.97e-01	-0.118000	4.98e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	11	4.98e-01	-0.118000	6.87e-01
NONSENSE MEDIATED DECAY NMD INDEPENDENT OF THE EXON JUNCTION COMPLEX EJC	88	5.60e-02	-0.118000	1.63e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	68	9.29e-02	0.118000	2.31e-01
LYSINE CATABOLISM	10	5.19e-01	-0.118000	7.00e-01
RESOLUTION OF SISTER CHROMATID COHESION	102	4.03e-02	-0.118000	1.30e-01
CELL CYCLE CHECKPOINTS	226	2.38e-03	-0.118000	1.53e-02
INTERFERON SIGNALING	115	2.96e-02	-0.118000	1.02e-01
PI 3K CASCADE FGFR4	12	4.83e-01	-0.117000	6.80e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	273	9.44e-04	-0.117000	7.08e-03
PHOSPHOLIPID METABOLISM	157	1.19e-02	-0.116000	5.31e-02
CELL JUNCTION ORGANIZATION	59	1.23e-01	-0.116000	2.86e-01
FGFR2 ALTERNATIVE SPLICING	17	4.07e-01	-0.116000	6.06e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	13	4.69e-01	-0.116000	6.65e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	4.69e-01	0.116000	6.65e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	1.80e-01	0.116000	3.63e-01
TGFBR3 PTM REGULATION	10	5.30e-01	0.115000	7.11e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	26	3.11e-01	0.115000	5.11e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	14	4.58e-01	0.115000	6.59e-01
HDACS DEACETYLATE HISTONES	29	2.86e-01	-0.115000	4.84e-01
NONHOMOLOGOUS END JOINING NHEJ	31	2.70e-01	0.114000	4.67e-01
REGULATION OF TP53 DEGRADATION	34	2.50e-01	-0.114000	4.45e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	20	3.78e-01	-0.114000	5.82e-01
S PHASE	140	2.03e-02	-0.114000	7.71e-02
MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL	164	1.25e-02	-0.113000	5.46e-02
NUCLEOTIDE CATABOLISM	28	3.00e-01	-0.113000	5.01e-01
ATTENUATION PHASE	13	4.84e-01	0.112000	6.80e-01
G0 AND EARLY G1	16	4.40e-01	-0.112000	6.44e-01
MTORC1 MEDIATED SIGNALLING	24	3.46e-01	-0.111000	5.50e-01
REGULATION OF INSULIN SECRETION	49	1.81e-01	-0.110000	3.63e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	3.62e-01	-0.110000	5.68e-01
ESR MEDIATED SIGNALING	102	5.58e-02	-0.110000	1.63e-01
CALCINEURIN ACTIVATES NFAT	10	5.49e-01	0.109000	7.27e-01
METABOLISM OF COFACTORS	23	3.64e-01	-0.109000	5.71e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	15	4.64e-01	-0.109000	6.62e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	5.31e-01	-0.109000	7.11e-01
CHROMOSOME MAINTENANCE	66	1.27e-01	0.109000	2.92e-01
RHOG GTPASE CYCLE	67	1.25e-01	-0.109000	2.87e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	10	5.53e-01	0.108000	7.28e-01
RHOA GTPASE CYCLE	132	3.25e-02	-0.108000	1.08e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	33	2.84e-01	-0.108000	4.81e-01
SIGNALING BY WNT	201	8.62e-03	-0.108000	4.15e-02
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	93	7.36e-02	-0.107000	1.96e-01
MTOR SIGNALLING	41	2.36e-01	-0.107000	4.28e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	3.97e-01	0.107000	5.96e-01
PYRUVATE METABOLISM	42	2.33e-01	0.106000	4.28e-01
G ALPHA 12 13 SIGNALLING EVENTS	69	1.27e-01	-0.106000	2.92e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	14	4.96e-01	-0.105000	6.87e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	12	5.29e-01	-0.105000	7.11e-01
SURFACTANT METABOLISM	14	4.99e-01	-0.104000	6.87e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	120	4.89e-02	-0.104000	1.48e-01
OXIDATIVE STRESS INDUCED SENESCENCE	37	2.73e-01	0.104000	4.68e-01
MITOTIC SPINDLE CHECKPOINT	96	7.95e-02	-0.104000	2.07e-01
G ALPHA S SIGNALLING EVENTS	62	1.59e-01	-0.103000	3.36e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	10	5.73e-01	0.103000	7.41e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	3.00e-01	-0.103000	5.01e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	18	4.52e-01	0.102000	6.54e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	12	5.40e-01	0.102000	7.16e-01
DUAL INCISION IN TC NER	61	1.68e-01	0.102000	3.49e-01
GLYCOSPHINGOLIPID METABOLISM	42	2.53e-01	-0.102000	4.49e-01
APOPTOTIC EXECUTION PHASE	42	2.55e-01	-0.102000	4.50e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	4.96e-01	0.102000	6.87e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	23	4.00e-01	-0.101000	5.97e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	5.44e-01	-0.101000	7.22e-01
MITF M REGULATED MELANOCYTE DEVELOPMENT	29	3.49e-01	-0.101000	5.53e-01
SIGNALING BY NOTCH1	18	4.61e-01	0.100000	6.60e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	5.84e-01	-0.100000	7.43e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	86	1.11e-01	-0.099500	2.66e-01
PLASMA LIPOPROTEIN REMODELING	19	4.53e-01	-0.099500	6.54e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	83	1.20e-01	-0.098800	2.83e-01
PI 3K CASCADE FGFR3	12	5.55e-01	-0.098400	7.28e-01
SHC MEDIATED CASCADE FGFR3	11	5.72e-01	-0.098300	7.41e-01
INTEGRATION OF ENERGY METABOLISM	59	1.92e-01	-0.098300	3.78e-01
ASPIRIN ADME	17	4.84e-01	-0.098000	6.80e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	73	1.48e-01	0.098000	3.25e-01
RAB GERANYLGERANYLATION	52	2.23e-01	-0.097800	4.15e-01
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE	18	4.78e-01	0.096500	6.77e-01
SPHINGOLIPID METABOLISM	72	1.57e-01	-0.096500	3.36e-01
VXPX CARGO TARGETING TO CILIUM	17	4.91e-01	-0.096500	6.87e-01
AFLATOXIN ACTIVATION AND DETOXIFICATION	10	5.98e-01	-0.096400	7.52e-01
SIGNALING BY PTK6	44	2.71e-01	-0.096000	4.67e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	31	3.55e-01	-0.096000	5.60e-01
HEME SIGNALING	12	5.65e-01	0.095900	7.36e-01
SIGNALING BY TGFB FAMILY MEMBERS	105	8.99e-02	-0.095900	2.25e-01
CELL CYCLE	508	2.76e-04	-0.094800	2.67e-03
TRANSCRIPTIONAL AND POST TRANSLATIONAL REGULATION OF MITF M EXPRESSION AND ACTIVITY	16	5.12e-01	-0.094700	6.95e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	72	1.65e-01	0.094700	3.44e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	11	5.88e-01	0.094300	7.44e-01
GLUTAMATE AND GLUTAMINE METABOLISM	10	6.07e-01	-0.094100	7.59e-01
SIGNALING BY ROBO RECEPTORS	20	4.67e-01	-0.094000	6.64e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	2.91e-01	0.093000	4.90e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	11	5.96e-01	0.092400	7.51e-01
INOSITOL PHOSPHATE METABOLISM	42	3.01e-01	-0.092200	5.01e-01
AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES	79	1.58e-01	-0.092000	3.36e-01
DUAL INCISION IN GG NER	41	3.09e-01	0.091800	5.09e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	135	6.72e-02	-0.091400	1.86e-01
STRIATED MUSCLE CONTRACTION	29	3.95e-01	-0.091200	5.95e-01
NONSENSE MEDIATED DECAY NMD	107	1.04e-01	-0.091100	2.54e-01
CARNITINE METABOLISM	14	5.55e-01	-0.091100	7.28e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	5.86e-01	-0.090900	7.44e-01
RHOQ GTPASE CYCLE	56	2.41e-01	-0.090600	4.33e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	29	4.00e-01	-0.090300	5.97e-01
INSULIN RECEPTOR SIGNALLING CASCADE	33	3.71e-01	-0.090100	5.74e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	13	5.75e-01	-0.089900	7.41e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	34	3.67e-01	0.089500	5.71e-01
RHOC GTPASE CYCLE	65	2.13e-01	-0.089400	4.04e-01
METABOLISM OF PORPHYRINS	21	4.79e-01	-0.089200	6.77e-01
SIGNALING BY NUCLEAR RECEPTORS	144	6.92e-02	-0.087900	1.88e-01
INTRAFLAGELLAR TRANSPORT	40	3.37e-01	-0.087700	5.42e-01
MYD88 MAL TIRAP CASCADE INITIATED ON PLASMA MEMBRANE	81	1.73e-01	-0.087700	3.52e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1089	1.78e-06	-0.086700	6.41e-05
CELLULAR RESPONSES TO STIMULI	420	2.42e-03	-0.086600	1.55e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	11	6.21e-01	-0.086200	7.68e-01
SIGNALING BY ERYTHROPOIETIN	16	5.51e-01	-0.086200	7.28e-01
NEDDYLATION	207	3.44e-02	-0.085500	1.12e-01
NOD1 2 SIGNALING PATHWAY	30	4.19e-01	-0.085200	6.21e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	12	6.16e-01	0.083700	7.65e-01
SIGNALING BY EGFR	43	3.49e-01	-0.082600	5.53e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	130	1.06e-01	-0.082200	2.57e-01
METABOLISM OF PROTEINS	1445	3.21e-07	-0.081600	1.60e-05
SIGNALING BY TGF BETA RECEPTOR COMPLEX	73	2.34e-01	-0.080600	4.28e-01
MITOTIC PROMETAPHASE	171	7.33e-02	-0.079500	1.96e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	16	5.83e-01	-0.079400	7.43e-01
REGULATION OF TNFR1 SIGNALING	46	3.54e-01	-0.079100	5.58e-01
PROTEIN UBIQUITINATION	56	3.08e-01	-0.078700	5.08e-01
TRANSLATION	218	4.57e-02	-0.078700	1.43e-01
SPRY REGULATION OF FGF SIGNALING	16	5.87e-01	0.078400	7.44e-01
PINK1 PRKN MEDIATED MITOPHAGY	30	4.61e-01	-0.077700	6.60e-01
VOLTAGE GATED POTASSIUM CHANNELS	21	5.38e-01	0.077700	7.16e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	21	5.38e-01	-0.077600	7.16e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	6.71e-01	0.077500	8.11e-01
POTASSIUM CHANNELS	56	3.19e-01	-0.077100	5.17e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	12	6.45e-01	-0.076900	7.89e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	13	6.31e-01	0.076900	7.77e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	25	5.07e-01	-0.076700	6.95e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	66	2.83e-01	0.076500	4.80e-01
ESTROGEN DEPENDENT GENE EXPRESSION	43	3.88e-01	0.076100	5.89e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	19	5.67e-01	-0.075800	7.38e-01
PLATELET CALCIUM HOMEOSTASIS	22	5.39e-01	-0.075600	7.16e-01
BASIGIN INTERACTIONS	18	5.79e-01	-0.075500	7.41e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	81	2.42e-01	0.075200	4.34e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	4.51e-01	0.074800	6.54e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	19	5.74e-01	-0.074500	7.41e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	26	5.11e-01	0.074500	6.95e-01
TNFR1 INDUCED NF KAPPA B SIGNALING PATHWAY	32	4.67e-01	-0.074300	6.64e-01
BIOLOGICAL OXIDATIONS	130	1.46e-01	-0.073900	3.23e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	10	6.86e-01	0.073800	8.26e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	19	5.78e-01	-0.073700	7.41e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	104	1.95e-01	-0.073600	3.80e-01
TELOMERE EXTENSION BY TELOMERASE	17	6.00e-01	0.073400	7.52e-01
NUCLEOTIDE EXCISION REPAIR	105	1.95e-01	0.073300	3.80e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	26	5.21e-01	-0.072800	7.01e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	5.76e-01	0.072300	7.41e-01
PARACETAMOL ADME	20	5.76e-01	-0.072200	7.41e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	28	5.11e-01	-0.071700	6.95e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	80	2.70e-01	-0.071400	4.67e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	22	5.63e-01	-0.071300	7.35e-01
NOTCH HLH TRANSCRIPTION PATHWAY	22	5.63e-01	-0.071300	7.35e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	51	3.80e-01	-0.071100	5.84e-01
METABOLISM OF RNA	559	4.39e-03	-0.070900	2.52e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	13	6.59e-01	0.070800	8.02e-01
STIMULI SENSING CHANNELS	62	3.39e-01	-0.070300	5.42e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	37	4.64e-01	-0.069600	6.62e-01
SIGNALING BY ERBB2	40	4.48e-01	-0.069400	6.51e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	31	5.04e-01	0.069300	6.92e-01
RNA POLYMERASE I TRANSCRIPTION	41	4.51e-01	-0.068000	6.54e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	24	5.65e-01	0.067900	7.36e-01
THE PHOTOTRANSDUCTION CASCADE	17	6.28e-01	-0.067800	7.75e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	65	3.45e-01	-0.067700	5.50e-01
ESTABLISHMENT OF SISTER CHROMATID COHESION	10	7.11e-01	0.067700	8.39e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	16	6.41e-01	-0.067400	7.87e-01
TRAFFICKING OF AMPA RECEPTORS	22	5.86e-01	-0.067100	7.44e-01
MITOCHONDRIAL PROTEIN DEGRADATION	70	3.39e-01	0.066100	5.42e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	14	6.70e-01	0.065800	8.11e-01
RHOBTB GTPASE CYCLE	34	5.11e-01	0.065200	6.95e-01
BASE EXCISION REPAIR AP SITE FORMATION	15	6.63e-01	-0.065000	8.05e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	17	6.43e-01	0.065000	7.88e-01
METABOLISM OF LIPIDS	463	1.83e-02	-0.064300	7.14e-02
RAF ACTIVATION	34	5.17e-01	-0.064300	6.98e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	92	2.88e-01	-0.064200	4.86e-01
LGI ADAM INTERACTIONS	10	7.27e-01	-0.063700	8.43e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	42	4.85e-01	-0.062300	6.80e-01
MET RECEPTOR RECYCLING	10	7.33e-01	-0.062200	8.46e-01
HYALURONAN METABOLISM	14	6.87e-01	-0.062200	8.26e-01
UNFOLDED PROTEIN RESPONSE UPR	10	7.36e-01	-0.061600	8.47e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	21	6.27e-01	-0.061300	7.74e-01
AMINE LIGAND BINDING RECEPTORS	14	6.93e-01	-0.061000	8.29e-01
MUSCLE CONTRACTION	126	2.39e-01	-0.060800	4.32e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	23	6.21e-01	0.059500	7.68e-01
HEME BIOSYNTHESIS	12	7.23e-01	-0.059100	8.39e-01
GLYCOSPHINGOLIPID CATABOLISM	28	5.89e-01	-0.059000	7.45e-01
REGULATION OF TP53 ACTIVITY	145	2.23e-01	-0.058700	4.15e-01
FRS MEDIATED FGFR1 SIGNALING	13	7.16e-01	-0.058300	8.39e-01
RNA POLYMERASE II PROMOTER ESCAPE	44	5.13e-01	0.057000	6.95e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	18	6.78e-01	-0.056500	8.18e-01
METABOLISM	1435	4.44e-04	-0.056200	3.96e-03
NEURONAL SYSTEM	202	1.69e-01	-0.056200	3.50e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	14	7.16e-01	0.056100	8.39e-01
NUCLEOTIDE BIOSYNTHESIS	12	7.37e-01	0.056100	8.47e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	49	4.98e-01	-0.056000	6.87e-01
AMINO ACIDS REGULATE MTORC1	46	5.11e-01	0.056000	6.95e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	5.79e-01	0.055800	7.41e-01
FRS MEDIATED FGFR2 SIGNALING	14	7.18e-01	-0.055700	8.39e-01
GENE EXPRESSION TRANSCRIPTION	921	4.60e-03	0.055600	2.57e-02
COMMON PATHWAY OF FIBRIN CLOT FORMATION	12	7.40e-01	-0.055400	8.48e-01
RIPK1 MEDIATED REGULATED NECROSIS	29	6.08e-01	-0.055100	7.59e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	21	6.62e-01	-0.055100	8.05e-01
DEADENYLATION DEPENDENT MRNA DECAY	48	5.13e-01	-0.054600	6.95e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	53	4.92e-01	0.054600	6.87e-01
FCERI MEDIATED CA 2 MOBILIZATION	23	6.52e-01	-0.054400	7.97e-01
MET ACTIVATES RAP1 AND RAC1	11	7.56e-01	-0.054000	8.61e-01
PROTEIN HYDROXYLATION	16	7.10e-01	0.053700	8.39e-01
VITAMIN B5 PANTOTHENATE METABOLISM	14	7.29e-01	-0.053400	8.44e-01
FORMATION OF TC NER PRE INCISION COMPLEX	49	5.19e-01	0.053200	7.00e-01
SIGNALING BY NOTCH3	19	6.92e-01	-0.052600	8.29e-01
RND2 GTPASE CYCLE	37	5.82e-01	0.052300	7.43e-01
O LINKED GLYCOSYLATION	72	4.43e-01	-0.052300	6.47e-01
ION CHANNEL TRANSPORT	118	3.31e-01	-0.051900	5.33e-01
GENERIC TRANSCRIPTION PATHWAY	690	2.19e-02	0.051500	8.13e-02
SULFUR AMINO ACID METABOLISM	19	6.99e-01	-0.051300	8.33e-01
FATTY ACID METABOLISM	133	3.08e-01	-0.051300	5.08e-01
RND3 GTPASE CYCLE	36	5.99e-01	-0.050700	7.52e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	6.15e-01	0.050700	7.65e-01
PROTEIN METHYLATION	17	7.19e-01	-0.050400	8.39e-01
TRANSLESION SYNTHESIS BY POLH	18	7.14e-01	-0.050000	8.39e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	34	6.15e-01	0.049900	7.65e-01
SNRNP ASSEMBLY	47	5.58e-01	0.049500	7.31e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	40	5.91e-01	0.049100	7.46e-01
SIGNAL TRANSDUCTION BY L1	19	7.13e-01	-0.048800	8.39e-01
PKR MEDIATED SIGNALING	60	5.14e-01	-0.048700	6.96e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	11	7.85e-01	-0.047500	8.80e-01
RHOD GTPASE CYCLE	49	5.68e-01	-0.047100	7.38e-01
HOMOLOGY DIRECTED REPAIR	93	4.33e-01	0.047100	6.38e-01
KERATAN SULFATE KERATIN METABOLISM	28	6.67e-01	-0.047000	8.08e-01
RND1 GTPASE CYCLE	38	6.16e-01	0.047000	7.65e-01
CYCLIN D ASSOCIATED EVENTS IN G1	41	6.07e-01	-0.046400	7.59e-01
AZATHIOPRINE ADME	20	7.22e-01	0.046000	8.39e-01
TNF SIGNALING	55	5.55e-01	-0.046000	7.28e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	32	6.58e-01	0.045200	8.02e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	168	3.14e-01	-0.045100	5.12e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	32	6.59e-01	-0.045100	8.02e-01
CELLULAR RESPONSE TO HEAT STRESS	81	4.84e-01	-0.045000	6.80e-01
FLT3 SIGNALING	26	6.92e-01	0.045000	8.29e-01
DNA DOUBLE STRAND BREAK REPAIR	123	3.90e-01	0.044900	5.90e-01
NETRIN 1 SIGNALING	12	7.88e-01	-0.044900	8.81e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	6.67e-01	0.044600	8.08e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	79	4.94e-01	-0.044500	6.87e-01
RHOB GTPASE CYCLE	65	5.36e-01	-0.044400	7.16e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	18	7.46e-01	-0.044100	8.51e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	12	7.92e-01	-0.043900	8.84e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	7.61e-01	0.043800	8.65e-01
SIGNALING BY FGFR	62	5.53e-01	-0.043600	7.28e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	11	8.04e-01	-0.043200	8.94e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	171	3.38e-01	-0.042600	5.42e-01
BASE EXCISION REPAIR	42	6.36e-01	0.042200	7.82e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	8.24e-01	0.040700	9.10e-01
TIE2 SIGNALING	16	7.85e-01	-0.039500	8.80e-01
TBC RABGAPS	33	6.95e-01	-0.039500	8.31e-01
MITOCHONDRIAL TRANSLATION	87	5.37e-01	0.038300	7.16e-01
SIGNALING BY RETINOIC ACID	34	7.00e-01	-0.038200	8.34e-01
INTERLEUKIN 17 SIGNALING	57	6.19e-01	-0.038100	7.67e-01
PURINE CATABOLISM	16	7.94e-01	0.037800	8.84e-01
NEUROTRANSMITTER RELEASE CYCLE	30	7.22e-01	-0.037600	8.39e-01
TP53 REGULATES METABOLIC GENES	66	5.99e-01	0.037500	7.52e-01
PEROXISOMAL LIPID METABOLISM	27	7.38e-01	-0.037200	8.47e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	7.36e-01	-0.036900	8.47e-01
SIGNALING BY TGFBR3	21	7.71e-01	-0.036700	8.74e-01
DARPP 32 EVENTS	15	8.08e-01	-0.036300	8.96e-01
GENE SILENCING BY RNA	40	6.98e-01	0.035500	8.33e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	7.10e-01	0.035300	8.39e-01
KERATAN SULFATE BIOSYNTHESIS	21	7.81e-01	-0.035100	8.80e-01
ADHERENS JUNCTIONS INTERACTIONS	29	7.45e-01	-0.034900	8.51e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	7.11e-01	-0.033500	8.39e-01
PROTEIN LOCALIZATION	95	5.81e-01	-0.032800	7.43e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	10	8.58e-01	0.032700	9.29e-01
RESOLUTION OF ABASIC SITES AP SITES	37	7.33e-01	0.032400	8.46e-01
NUCLEAR ENVELOPE BREAKDOWN	45	7.08e-01	-0.032300	8.39e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	41	7.21e-01	0.032200	8.39e-01
RHOBTB2 GTPASE CYCLE	22	7.96e-01	0.031900	8.85e-01
PROTEIN LIPOYLATION	10	8.62e-01	0.031900	9.30e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	23	7.93e-01	0.031600	8.84e-01
MRNA CAPPING	28	7.73e-01	-0.031500	8.75e-01
DNA REPAIR	257	3.87e-01	0.031400	5.89e-01
FOXO MEDIATED TRANSCRIPTION	20	8.11e-01	0.030900	8.99e-01
SIGNALING BY ERBB4	32	7.63e-01	0.030800	8.66e-01
INTERLEUKIN 15 SIGNALING	10	8.67e-01	0.030600	9.30e-01
EGFR DOWNREGULATION	28	7.79e-01	-0.030600	8.80e-01
FRS MEDIATED FGFR4 SIGNALING	13	8.49e-01	-0.030600	9.27e-01
PEXOPHAGY	10	8.69e-01	-0.030100	9.31e-01
NEGATIVE REGULATION OF FLT3	13	8.57e-01	-0.028900	9.29e-01
SIGNALING BY FGFR3	32	7.78e-01	0.028800	8.80e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	54	7.17e-01	0.028600	8.39e-01
SYNTHESIS OF PC	21	8.23e-01	-0.028200	9.10e-01
GAMMA CARBOXYLATION HYPUSINYLATION HYDROXYLATION AND ARYLSULFATASE ACTIVATION	45	7.44e-01	0.028200	8.51e-01
DNA DAMAGE BYPASS	46	7.43e-01	0.028000	8.51e-01
MITF M DEPENDENT GENE EXPRESSION	15	8.54e-01	-0.027400	9.29e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	7.83e-01	-0.027300	8.80e-01
SUMOYLATION	144	5.78e-01	0.026900	7.41e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	56	7.29e-01	0.026800	8.44e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	10	8.84e-01	0.026600	9.42e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	14	8.63e-01	-0.026600	9.30e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	10	8.87e-01	0.026000	9.42e-01
RNA POLYMERASE II PRE TRANSCRIPTION EVENTS	72	7.05e-01	-0.025900	8.38e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	38	7.86e-01	-0.025500	8.80e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	16	8.61e-01	-0.025200	9.30e-01
CELLULAR SENESCENCE	91	6.84e-01	-0.024700	8.24e-01
PROCESSING OF INTRONLESS PRE MRNAS	20	8.50e-01	-0.024400	9.27e-01
KERATAN SULFATE DEGRADATION	12	8.84e-01	0.024300	9.42e-01
NEUREXINS AND NEUROLIGINS	21	8.52e-01	-0.023500	9.29e-01
METABOLISM OF STEROIDS	80	7.19e-01	0.023300	8.39e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	79	7.22e-01	0.023200	8.39e-01
INTERFERON GAMMA SIGNALING	18	8.67e-01	-0.022900	9.30e-01
HATS ACETYLATE HISTONES	29	8.33e-01	0.022600	9.17e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	30	8.32e-01	-0.022400	9.16e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	23	8.56e-01	0.021900	9.29e-01
SIGNALING BY FGFR4	32	8.31e-01	0.021800	9.16e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	56	7.83e-01	0.021300	8.80e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	15	8.88e-01	-0.021100	9.42e-01
GLUTATHIONE CONJUGATION	32	8.37e-01	-0.021000	9.19e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	29	8.57e-01	-0.019300	9.29e-01
CA2 PATHWAY	37	8.39e-01	-0.019300	9.20e-01
NRAGE SIGNALS DEATH THROUGH JNK	49	8.17e-01	0.019100	9.04e-01
CELL CELL JUNCTION ORGANIZATION	37	8.41e-01	0.019100	9.21e-01
MITOPHAGY	37	8.49e-01	0.018000	9.27e-01
ION HOMEOSTASIS	45	8.35e-01	-0.018000	9.17e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	9.22e-01	0.016900	9.66e-01
DNA DAMAGE RECOGNITION IN GG NER	38	8.66e-01	0.015900	9.30e-01
MYOGENESIS	17	9.11e-01	0.015700	9.59e-01
ONCOGENE INDUCED SENESCENCE	16	9.19e-01	-0.014800	9.64e-01
DOWNREGULATION OF ERBB2 SIGNALING	24	9.04e-01	-0.014200	9.56e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	45	8.70e-01	-0.014100	9.31e-01
FRS MEDIATED FGFR3 SIGNALING	13	9.33e-01	-0.013400	9.71e-01
FATTY ACYL COA BIOSYNTHESIS	26	9.06e-01	0.013300	9.57e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	9.34e-01	0.013300	9.71e-01
SIGNALING BY FGFR2	51	8.71e-01	-0.013100	9.31e-01
P75NTR SIGNALS VIA NF KB	16	9.29e-01	0.012900	9.70e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	9.44e-01	0.012700	9.74e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	34	8.98e-01	-0.012700	9.51e-01
PEROXISOMAL PROTEIN IMPORT	61	8.65e-01	0.012600	9.30e-01
ION TRANSPORT BY P TYPE ATPASES	41	8.92e-01	0.012200	9.46e-01
ENOS ACTIVATION	12	9.42e-01	-0.012100	9.73e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	9.36e-01	-0.011900	9.71e-01
MRNA SPLICING	190	7.86e-01	0.011400	8.80e-01
TRANSCRIPTIONAL REGULATION BY TP53	274	7.56e-01	-0.010900	8.61e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	19	9.35e-01	-0.010800	9.71e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	9.10e-01	0.010800	9.59e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	86	8.66e-01	0.010500	9.30e-01
RESOLUTION OF D LOOP STRUCTURES	29	9.23e-01	-0.010400	9.66e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	62	8.88e-01	-0.010400	9.42e-01
HSF1 DEPENDENT TRANSACTIVATION	23	9.34e-01	-0.009970	9.71e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	16	9.48e-01	-0.009410	9.74e-01
G2 M DNA DAMAGE CHECKPOINT	52	9.10e-01	-0.009040	9.59e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	9.48e-01	-0.008030	9.74e-01
IRON UPTAKE AND TRANSPORT	46	9.29e-01	-0.007560	9.70e-01
DRUG ADME	63	9.18e-01	-0.007540	9.64e-01
SIGNALING BY NOTCH	38	9.37e-01	-0.007360	9.71e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	74	9.16e-01	-0.007120	9.63e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	30	9.46e-01	-0.007090	9.74e-01
GROWTH HORMONE RECEPTOR SIGNALING	10	9.69e-01	-0.007080	9.88e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	12	9.69e-01	0.006430	9.88e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	254	8.73e-01	0.005840	9.32e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	24	9.66e-01	0.005040	9.88e-01
INFLAMMASOMES	12	9.77e-01	-0.004830	9.92e-01
CARDIAC CONDUCTION	76	9.42e-01	-0.004820	9.73e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	27	9.66e-01	-0.004800	9.88e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	10	9.80e-01	0.004630	9.94e-01
SIGNALING BY FGFR1	41	9.59e-01	-0.004620	9.84e-01
RAS PROCESSING	23	9.71e-01	-0.004390	9.88e-01
EFFECTS OF PIP2 HYDROLYSIS	22	9.72e-01	0.004320	9.88e-01
DEATH RECEPTOR SIGNALING	131	9.33e-01	0.004250	9.71e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	40	9.68e-01	-0.003650	9.88e-01
CHROMATIN MODIFYING ENZYMES	136	9.42e-01	-0.003600	9.73e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	36	9.71e-01	0.003550	9.88e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	12	9.84e-01	-0.003350	9.94e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	14	9.84e-01	0.003000	9.94e-01
SIGNALING BY ALK	14	9.87e-01	-0.002520	9.94e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	30	9.83e-01	-0.002300	9.94e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	16	9.88e-01	-0.002120	9.94e-01
RET SIGNALING	34	9.83e-01	0.002100	9.94e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	9.93e-01	0.001460	9.97e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	60	9.86e-01	0.001270	9.94e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	11	9.95e-01	-0.001070	9.97e-01
METABOLISM OF NUCLEOTIDES	77	9.89e-01	-0.000914	9.94e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	23	9.95e-01	0.000680	9.97e-01
MRNA SPLICING MINOR PATHWAY	47	9.95e-01	0.000563	9.97e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	9.97e-01	-0.000451	9.97e-01

---

Detailed Gene set reports

ENDOSOMAL VACUOLAR PATHWAY

set	ENDOSOMAL VACUOLAR PATHWAY
setSize	10
pANOVA	0.000174
s.dist	-0.685
p.adjustANOVA	0.0018

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2-T23	-7213.5
H2-T22	-7126.5
H2-Q4	-6576.5
H2-K1	-6356.5
H2-Q6	-6315.5
B2m	-5962.5
H2-M3	-5646.5
H2-Q7	-5203.5
H2-T10	-2083.5
Lnpep	1013.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2-T23	-7213.5
H2-T22	-7126.5
H2-Q4	-6576.5
H2-K1	-6356.5
H2-Q6	-6315.5
B2m	-5962.5
H2-M3	-5646.5
H2-Q7	-5203.5
H2-T10	-2083.5
Lnpep	1013.5

---

ER PHAGOSOME PATHWAY

set	ER PHAGOSOME PATHWAY
setSize	19
pANOVA	9.27e-05
s.dist	-0.518
p.adjustANOVA	0.00111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2-T23	-7213.5
H2-T22	-7126.5
H2-Q4	-6576.5
Tap2	-6388.5
H2-K1	-6356.5
H2-Q6	-6315.5
Vamp3	-6160.5
B2m	-5962.5
Tapbp	-5917.5
H2-M3	-5646.5
H2-Q7	-5203.5
Sec22b	-4524.5
Tap1	-2689.5
H2-T10	-2083.5
Calr	-1710.5
Snap23	129.5
Vamp8	560.5
Pdia3	1124.5
Stx4a	4550.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2-T23	-7213.5
H2-T22	-7126.5
H2-Q4	-6576.5
Tap2	-6388.5
H2-K1	-6356.5
H2-Q6	-6315.5
Vamp3	-6160.5
B2m	-5962.5
Tapbp	-5917.5
H2-M3	-5646.5
H2-Q7	-5203.5
Sec22b	-4524.5
Tap1	-2689.5
H2-T10	-2083.5
Calr	-1710.5
Snap23	129.5
Vamp8	560.5
Pdia3	1124.5
Stx4a	4550.5

---

GENERATION OF SECOND MESSENGER MOLECULES

set	GENERATION OF SECOND MESSENGER MOLECULES
setSize	12
pANOVA	0.00189
s.dist	-0.518
p.adjustANOVA	0.0125

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Plcg2	-7471.5
Pak2	-7076.5
Pak1	-6577.5
H2-Ab1	-6190.5
H2-Eb1	-6179.5
H2-Aa	-5973.5
Cd4	-4891.5
Lcp2	-4423.5
Plcg1	-2125.5
Pak3	-489.5
Cd247	1310.5
Nck1	3641.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Plcg2	-7471.5
Pak2	-7076.5
Pak1	-6577.5
H2-Ab1	-6190.5
H2-Eb1	-6179.5
H2-Aa	-5973.5
Cd4	-4891.5
Lcp2	-4423.5
Plcg1	-2125.5
Pak3	-489.5
Cd247	1310.5
Nck1	3641.5

---

INITIAL TRIGGERING OF COMPLEMENT

set	INITIAL TRIGGERING OF COMPLEMENT
setSize	13
pANOVA	0.0015
s.dist	-0.509
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ighg2c	-6965.5
C1qa	-6889.5
C1qb	-6515.5
Colec11	-6475.5
C4b	-6210.5
Masp1	-5327.5
C3	-4366.5
C1qc	-4208.5
C1ra	-3172.5
Gzmm	-2958.5
Fcna	-2526.5
Cfp	901.5
Cfd	5336.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ighg2c	-6965.5
C1qa	-6889.5
C1qb	-6515.5
Colec11	-6475.5
C4b	-6210.5
Masp1	-5327.5
C3	-4366.5
C1qc	-4208.5
C1ra	-3172.5
Gzmm	-2958.5
Fcna	-2526.5
Cfp	901.5
Cfd	5336.5

---

NCAM1 INTERACTIONS

set	NCAM1 INTERACTIONS
setSize	16
pANOVA	0.000523
s.dist	-0.501
p.adjustANOVA	0.0044

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Col4a4	-7068.5
Col6a3	-7051.5
Col4a3	-6741.5
Col4a2	-6463.5
Col4a1	-6405.5
Col3a1	-6278.5
Col6a1	-5925.5
Col6a2	-4973.5
St8sia2	-4886.5
Col5a1	-4525.5
Col5a2	-3971.5
Col9a2	-2728.5
Col5a3	-996.5
Col6a6	611.5
St8sia4	3253.5
Col4a5	4319.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Col4a4	-7068.5
Col6a3	-7051.5
Col4a3	-6741.5
Col4a2	-6463.5
Col4a1	-6405.5
Col3a1	-6278.5
Col6a1	-5925.5
Col6a2	-4973.5
St8sia2	-4886.5
Col5a1	-4525.5
Col5a2	-3971.5
Col9a2	-2728.5
Col5a3	-996.5
Col6a6	611.5
St8sia4	3253.5
Col4a5	4319.5

---

RAP1 SIGNALLING

set	RAP1 SIGNALLING
setSize	15
pANOVA	0.000901
s.dist	-0.495
p.adjustANOVA	0.00682

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rap1b	-7347.5
Rapgef4	-6785.5
Prkacb	-6782.5
Ywhaz	-6592.5
Ywhab	-6504.5
Prkg1	-6076.5
Rap1gap2	-5017.5
Rap1gap	-4500.5
Sipa1	-3974.5
Rasgrp1	-2543.5
Rapgef3	-1187.5
Rap1a	-640.5
Raf1	-178.5
Prkaca	1203.5
Rasgrp2	1496.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rap1b	-7347.5
Rapgef4	-6785.5
Prkacb	-6782.5
Ywhaz	-6592.5
Ywhab	-6504.5
Prkg1	-6076.5
Rap1gap2	-5017.5
Rap1gap	-4500.5
Sipa1	-3974.5
Rasgrp1	-2543.5
Rapgef3	-1187.5
Rap1a	-640.5
Raf1	-178.5
Prkaca	1203.5
Rasgrp2	1496.5

---

RHO GTPASES ACTIVATE KTN1

set	RHO GTPASES ACTIVATE KTN1
setSize	10
pANOVA	0.00699
s.dist	-0.493
p.adjustANOVA	0.0353

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ktn1	-7507.5
Klc2	-7269.5
Kif5b	-6802.5
Rhoa	-5815.5
Rhog	-4733.5
Klc1	-3103.5
Kif5a	-2917.5
Klc4	-1524.5
Cdc42	707.5
Rac1	2187.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ktn1	-7507.5
Klc2	-7269.5
Kif5b	-6802.5
Rhoa	-5815.5
Rhog	-4733.5
Klc1	-3103.5
Kif5a	-2917.5
Klc4	-1524.5
Cdc42	707.5
Rac1	2187.5

---

ANTIGEN PROCESSING CROSS PRESENTATION

set	ANTIGEN PROCESSING CROSS PRESENTATION
setSize	72
pANOVA	1.84e-12
s.dist	-0.48
p.adjustANOVA	3.31e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	-7546.5
Psmc1	-7288.5
H2-T23	-7213.5
H2-T22	-7126.5
Psmd10	-7064.5
Psme2	-7040.5
Ncf2	-6981.5
Psmb10	-6939.5
H2-Q4	-6576.5
Psmc4	-6549.5
Psma5	-6525.5
Fcgr1	-6509.5
Tap2	-6388.5
H2-K1	-6356.5
Psmd2	-6327.5
H2-Q6	-6315.5
Psme1	-6257.5
Ncf4	-6177.5
Vamp3	-6160.5
Psmd1	-6039.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	-7546.5
Psmc1	-7288.5
H2-T23	-7213.5
H2-T22	-7126.5
Psmd10	-7064.5
Psme2	-7040.5
Ncf2	-6981.5
Psmb10	-6939.5
H2-Q4	-6576.5
Psmc4	-6549.5
Psma5	-6525.5
Fcgr1	-6509.5
Tap2	-6388.5
H2-K1	-6356.5
Psmd2	-6327.5
H2-Q6	-6315.5
Psme1	-6257.5
Ncf4	-6177.5
Vamp3	-6160.5
Psmd1	-6039.5
Psmd11	-5965.5
B2m	-5962.5
Tapbp	-5917.5
H2-M3	-5646.5
Psma2	-5618.5
Psmb8	-5467.5
Itgav	-5394.5
Cybb	-5377.5
Psmd8	-5359.5
Psmd7	-5325.5
Cyba	-5215.5
H2-Q7	-5203.5
Psmc5	-5161.5
Psmd6	-4829.5
Psme3	-4691.5
Mrc1	-4640.5
Psmc2	-4540.5
Sec22b	-4524.5
Ncf1	-4417.5
Psmb1	-4379.5
Mrc2	-4324.5
Psmd13	-3886.5
Psmd3	-3817.5
Psmd4	-3794.5
Psmd12	-3563.5
Psmb4	-3183.5
Psmd14	-2762.5
Tap1	-2689.5
Psma4	-2352.5
H2-T10	-2083.5
Cd36	-1937.5
Calr	-1710.5
Psmb2	-1497.5
Psma7	-1409.5
Psma1	-1280.5
Psmd5	-1273.5
Psmb7	-1206.5
Psma6	-877.5
Psmc3	-9.5
Snap23	129.5
Psmc6	483.5
Vamp8	560.5
Lnpep	1013.5
Pdia3	1124.5
Psmd9	1293.5
Psme4	1297.5
Psmb6	1690.5
Psme2b	2110.5
Psmb3	2137.5
Psma3	2596.5
Stx4a	4550.5
Psmf1	4753.5

---

RETROGRADE NEUROTROPHIN SIGNALLING

set	RETROGRADE NEUROTROPHIN SIGNALLING
setSize	10
pANOVA	0.00913
s.dist	-0.476
p.adjustANOVA	0.0432

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Dnal4	-7461.5
Ap2a2	-5932.5
Ap2a1	-5629.5
Ap2s1	-5078.5
Ngf	-4719.5
Ap2b1	-4479.5
Cltc	-2772.5
Ap2m1	-2602.5
Sh3gl2	1368.5
Clta	1781.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Dnal4	-7461.5
Ap2a2	-5932.5
Ap2a1	-5629.5
Ap2s1	-5078.5
Ngf	-4719.5
Ap2b1	-4479.5
Cltc	-2772.5
Ap2m1	-2602.5
Sh3gl2	1368.5
Clta	1781.5

---

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

set	A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize	19
pANOVA	0.000547
s.dist	-0.458
p.adjustANOVA	0.00456

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sdc4	-7387.5
Bgn	-6197.5
Gpc4	-6064.5
B4galt7	-6058.5
Agrn	-5940.5
Sdc3	-5505.5
B3gat3	-5432.5
Gpc3	-5345.5
Gpc6	-5130.5
Sdc1	-4854.5
Cspg4	-4438.5
Vcan	-3082.5
Cspg5	-2446.5
Sdc2	-1162.5
Dcn	-997.5
Gpc1	-580.5
Xylt2	503.5
Xylt1	2130.5
B3galt6	3149.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sdc4	-7387.5
Bgn	-6197.5
Gpc4	-6064.5
B4galt7	-6058.5
Agrn	-5940.5
Sdc3	-5505.5
B3gat3	-5432.5
Gpc3	-5345.5
Gpc6	-5130.5
Sdc1	-4854.5
Cspg4	-4438.5
Vcan	-3082.5
Cspg5	-2446.5
Sdc2	-1162.5
Dcn	-997.5
Gpc1	-580.5
Xylt2	503.5
Xylt1	2130.5
B3galt6	3149.5

---

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

set	CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize	45
pANOVA	2.36e-07
s.dist	-0.445
p.adjustANOVA	1.25e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	-7546.5
Psmc1	-7288.5
Psmd10	-7064.5
Psme2	-7040.5
Psmb10	-6939.5
Psmc4	-6549.5
Psma5	-6525.5
Fcgr1	-6509.5
Psmd2	-6327.5
Psme1	-6257.5
Psmd1	-6039.5
Psmd11	-5965.5
Psma2	-5618.5
Psmb8	-5467.5
Psmd8	-5359.5
Psmd7	-5325.5
Psmc5	-5161.5
Psmd6	-4829.5
Psme3	-4691.5
Mrc1	-4640.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	-7546.5
Psmc1	-7288.5
Psmd10	-7064.5
Psme2	-7040.5
Psmb10	-6939.5
Psmc4	-6549.5
Psma5	-6525.5
Fcgr1	-6509.5
Psmd2	-6327.5
Psme1	-6257.5
Psmd1	-6039.5
Psmd11	-5965.5
Psma2	-5618.5
Psmb8	-5467.5
Psmd8	-5359.5
Psmd7	-5325.5
Psmc5	-5161.5
Psmd6	-4829.5
Psme3	-4691.5
Mrc1	-4640.5
Psmc2	-4540.5
Psmb1	-4379.5
Mrc2	-4324.5
Psmd13	-3886.5
Psmd3	-3817.5
Psmd4	-3794.5
Psmd12	-3563.5
Psmb4	-3183.5
Psmd14	-2762.5
Psma4	-2352.5
Psmb2	-1497.5
Psma7	-1409.5
Psma1	-1280.5
Psmd5	-1273.5
Psmb7	-1206.5
Psma6	-877.5
Psmc3	-9.5
Psmc6	483.5
Psmd9	1293.5
Psme4	1297.5
Psmb6	1690.5
Psme2b	2110.5
Psmb3	2137.5
Psma3	2596.5
Psmf1	4753.5

---

TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY

set	TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY
setSize	11
pANOVA	0.0108
s.dist	-0.444
p.adjustANOVA	0.0498

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Birc3	-7400.5
Traf3	-7111.5
Traf2	-6924.5
Tnfrsf12a	-6913.5
Map3k14	-5202.5
Ltbr	-3322.5
Cd40	-3041.5
Tnfrsf11a	-540.5
Birc2	1006.5
Tnfsf12	1085.5
Tnfsf13b	1989.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Birc3	-7400.5
Traf3	-7111.5
Traf2	-6924.5
Tnfrsf12a	-6913.5
Map3k14	-5202.5
Ltbr	-3322.5
Cd40	-3041.5
Tnfrsf11a	-540.5
Birc2	1006.5
Tnfsf12	1085.5
Tnfsf13b	1989.5

---

SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX

set	SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
setSize	11
pANOVA	0.0112
s.dist	-0.442
p.adjustANOVA	0.0507

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ptgds	-7044.5
Ptgs2	-6099.5
Ptges2	-5934.5
Cbr1	-5881.5
Tbxas1	-5728.5
Ptgis	-5409.5
Ptgs1	-4702.5
Akr1c21	-2657.5
Ptges	145.5
Hpgds	3527.5
Ptges3	3578.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ptgds	-7044.5
Ptgs2	-6099.5
Ptges2	-5934.5
Cbr1	-5881.5
Tbxas1	-5728.5
Ptgis	-5409.5
Ptgs1	-4702.5
Akr1c21	-2657.5
Ptges	145.5
Hpgds	3527.5
Ptges3	3578.5

---

RHO GTPASES ACTIVATE NADPH OXIDASES

set	RHO GTPASES ACTIVATE NADPH OXIDASES
setSize	18
pANOVA	0.00122
s.dist	-0.44
p.adjustANOVA	0.00889

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Prkcz	-7451.5
Ncf2	-6981.5
Mapk11	-6823.5
Prkcd	-6578.5
Ncf4	-6177.5
Mapk3	-6090.5
Cybb	-5377.5
Prkcb	-5364.5
Cyba	-5215.5
Rac2	-5129.5
Ncf1	-4417.5
Pik3c3	-4002.5
Mapk14	-3091.5
Pik3r4	-694.5
Rac1	2187.5
Noxo1	3285.5
Pin1	3518.5
Mapk1	5380.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Prkcz	-7451.5
Ncf2	-6981.5
Mapk11	-6823.5
Prkcd	-6578.5
Ncf4	-6177.5
Mapk3	-6090.5
Cybb	-5377.5
Prkcb	-5364.5
Cyba	-5215.5
Rac2	-5129.5
Ncf1	-4417.5
Pik3c3	-4002.5
Mapk14	-3091.5
Pik3r4	-694.5
Rac1	2187.5
Noxo1	3285.5
Pin1	3518.5
Mapk1	5380.5

---

PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS

set	PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS
setSize	10
pANOVA	0.0169
s.dist	-0.436
p.adjustANOVA	0.0671

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Csk	-6601.5
H2-Ab1	-6190.5
H2-Eb1	-6179.5
H2-Aa	-5973.5
Cd4	-4891.5
Ptprj	-4739.5
Ptprc	-3191.5
Pag1	213.5
Cd247	1310.5
Ptpn22	3758.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Csk	-6601.5
H2-Ab1	-6190.5
H2-Eb1	-6179.5
H2-Aa	-5973.5
Cd4	-4891.5
Ptprj	-4739.5
Ptprc	-3191.5
Pag1	213.5
Cd247	1310.5
Ptpn22	3758.5

---

RAF INDEPENDENT MAPK1 3 ACTIVATION

set	RAF INDEPENDENT MAPK1 3 ACTIVATION
setSize	20
pANOVA	0.000745
s.dist	-0.436
p.adjustANOVA	0.00587

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Dusp7	-7360.5
Dusp6	-7226.5
Mapk3	-6090.5
Ptpn11	-5729.5
Dusp5	-5500.5
Il6st	-5380.5
Pea15a	-5308.5
Il6ra	-5174.5
Cdk1	-5043.5
Dusp4	-5033.5
Dusp8	-4358.5
Jak2	-4143.5
Map2k1	-4068.5
Dusp2	-2553.5
Dusp1	-2074.5
Map2k2	-1513.5
Tyk2	1776.5
Dusp16	2154.5
Dusp10	2416.5
Mapk1	5380.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Dusp7	-7360.5
Dusp6	-7226.5
Mapk3	-6090.5
Ptpn11	-5729.5
Dusp5	-5500.5
Il6st	-5380.5
Pea15a	-5308.5
Il6ra	-5174.5
Cdk1	-5043.5
Dusp4	-5033.5
Dusp8	-4358.5
Jak2	-4143.5
Map2k1	-4068.5
Dusp2	-2553.5
Dusp1	-2074.5
Map2k2	-1513.5
Tyk2	1776.5
Dusp16	2154.5
Dusp10	2416.5
Mapk1	5380.5

---

SUMOYLATION OF IMMUNE RESPONSE PROTEINS

set	SUMOYLATION OF IMMUNE RESPONSE PROTEINS
setSize	11
pANOVA	0.0205
s.dist	-0.403
p.adjustANOVA	0.0776

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Nfkb2	-7342.5
Rela	-6526.5
Nfkbia	-5680.5
Topors	-4793.5
Pias3	-4474.5
Ikbkg	-4230.5
Sumo1	-1352.5
Sumo3	-567.5
Ikbke	-231.5
Ube2i	1079.5
Pias4	1137.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Nfkb2	-7342.5
Rela	-6526.5
Nfkbia	-5680.5
Topors	-4793.5
Pias3	-4474.5
Ikbkg	-4230.5
Sumo1	-1352.5
Sumo3	-567.5
Ikbke	-231.5
Ube2i	1079.5
Pias4	1137.5

---

IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL

set	IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL
setSize	52
pANOVA	5.42e-07
s.dist	-0.402
p.adjustANOVA	2.44e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Siglece	-7520.5
Icam1	-7462.5
H2-T23	-7213.5
H2-T22	-7126.5
Vcam1	-7115.5
H2-Q4	-6576.5
H2-K1	-6356.5
H2-Q6	-6315.5
Col3a1	-6278.5
Trem2	-6196.5
B2m	-5962.5
Cxadr	-5655.5
H2-M3	-5646.5
Col1a1	-5503.5
Siglec1	-5421.5
Cd300lb	-5413.5
Cd34	-5231.5
H2-Q7	-5203.5
Pilra	-5124.5
Fcgr3	-5006.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Siglece	-7520.5
Icam1	-7462.5
H2-T23	-7213.5
H2-T22	-7126.5
Vcam1	-7115.5
H2-Q4	-6576.5
H2-K1	-6356.5
H2-Q6	-6315.5
Col3a1	-6278.5
Trem2	-6196.5
B2m	-5962.5
Cxadr	-5655.5
H2-M3	-5646.5
Col1a1	-5503.5
Siglec1	-5421.5
Cd300lb	-5413.5
Cd34	-5231.5
H2-Q7	-5203.5
Pilra	-5124.5
Fcgr3	-5006.5
Col1a2	-4728.5
Cd300lg	-4579.5
C3	-4366.5
Ifitm3	-4274.5
Slamf7	-4162.5
Itgb2	-4087.5
Icam2	-4014.5
Pianp	-3803.5
Cd33	-3717.5
Cd40	-3041.5
Itga4	-2974.5
Cd200	-2926.5
Fcgr2b	-2911.5
Cd300a	-2851.5
Lair1	-2564.5
Tyrobp	-2256.5
H2-T10	-2083.5
Cd81	-1815.5
Nectin2	-1597.5
Cd1d1	-1386.5
Itgb1	-1133.5
Npdc1	285.5
Pvr	895.5
Cd247	1310.5
Ifitm2	1621.5
Cd300c2	1661.5
Itgb7	2286.5
Ifitm1	4051.5
Cd226	4441.5
Itgal	5038.5
Sell	5486.5
Fcgr4	5705.5

---

GPVI MEDIATED ACTIVATION CASCADE

set	GPVI MEDIATED ACTIVATION CASCADE
setSize	29
pANOVA	0.000228
s.dist	-0.395
p.adjustANOVA	0.00223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Plcg2	-7471.5
Pik3r3	-7413.5
Fyn	-6707.5
Rhoa	-5815.5
Ptpn11	-5729.5
Col1a1	-5503.5
Pik3r5	-5230.5
Rac2	-5129.5
Rhog	-4733.5
Col1a2	-4728.5
Lcp2	-4423.5
Ptpn6	-4242.5
Pik3ca	-3991.5
Pdpn	-3898.5
Vav1	-3815.5
Rhob	-3473.5
Fcer1g	-2756.5
Pik3r6	-2525.5
Pdpk1	-2084.5
Lyn	-2030.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Plcg2	-7471.5
Pik3r3	-7413.5
Fyn	-6707.5
Rhoa	-5815.5
Ptpn11	-5729.5
Col1a1	-5503.5
Pik3r5	-5230.5
Rac2	-5129.5
Rhog	-4733.5
Col1a2	-4728.5
Lcp2	-4423.5
Ptpn6	-4242.5
Pik3ca	-3991.5
Pdpn	-3898.5
Vav1	-3815.5
Rhob	-3473.5
Fcer1g	-2756.5
Pik3r6	-2525.5
Pdpk1	-2084.5
Lyn	-2030.5
Pik3cg	-1965.5
Pik3r1	-1702.5
Syk	-526.5
Pik3r2	573.5
Cdc42	707.5
Vav3	1139.5
Rac1	2187.5
Pik3cb	3006.5
Vav2	3188.5

---

ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA

set	ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA
setSize	12
pANOVA	0.0179
s.dist	-0.395
p.adjustANOVA	0.0702

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Bcl2	-7481.5
Bid	-7264.5
Ppp3cc	-6663.5
Ywhaz	-6592.5
Ywhab	-6504.5
Ywhag	-4321.5
Ywhaq	-4301.5
Ywhah	-953.5
Ywhae	-94.5
Bad	946.5
Ppp3r1	1405.5
Sfn	6648.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Bcl2	-7481.5
Bid	-7264.5
Ppp3cc	-6663.5
Ywhaz	-6592.5
Ywhab	-6504.5
Ywhag	-4321.5
Ywhaq	-4301.5
Ywhah	-953.5
Ywhae	-94.5
Bad	946.5
Ppp3r1	1405.5
Sfn	6648.5

---

ACYL CHAIN REMODELLING OF PG

set	ACYL CHAIN REMODELLING OF PG
setSize	10
pANOVA	0.0323
s.dist	-0.391
p.adjustANOVA	0.108

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pla2g2d	-7426.5
Lpcat4	-7102.5
Pla2g4a	-7001.5
Pla2g12a	-6678.5
Lpgat1	-4682.5
Pla2r1	-3073.5
Crls1	-2345.5
Pla2g5	-17.5
Lpcat1	4152.5
Pla2g4b	5139.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pla2g2d	-7426.5
Lpcat4	-7102.5
Pla2g4a	-7001.5
Pla2g12a	-6678.5
Lpgat1	-4682.5
Pla2r1	-3073.5
Crls1	-2345.5
Pla2g5	-17.5
Lpcat1	4152.5
Pla2g4b	5139.5

---

DAP12 INTERACTIONS

set	DAP12 INTERACTIONS
setSize	31
pANOVA	0.000208
s.dist	-0.385
p.adjustANOVA	0.00208

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Plcg2	-7471.5
H2-T23	-7213.5
H2-T22	-7126.5
Fyn	-6707.5
H2-Q4	-6576.5
H2-K1	-6356.5
H2-Q6	-6315.5
Trem2	-6196.5
B2m	-5962.5
H2-M3	-5646.5
Clec5a	-5619.5
Cd300lb	-5413.5
H2-Q7	-5203.5
Lcp2	-4423.5
Pik3ca	-3991.5
Sos1	-3095.5
Kras	-2812.5
Tyrobp	-2256.5
Plcg1	-2125.5
H2-T10	-2083.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Plcg2	-7471.5
H2-T23	-7213.5
H2-T22	-7126.5
Fyn	-6707.5
H2-Q4	-6576.5
H2-K1	-6356.5
H2-Q6	-6315.5
Trem2	-6196.5
B2m	-5962.5
H2-M3	-5646.5
Clec5a	-5619.5
Cd300lb	-5413.5
H2-Q7	-5203.5
Lcp2	-4423.5
Pik3ca	-3991.5
Sos1	-3095.5
Kras	-2812.5
Tyrobp	-2256.5
Plcg1	-2125.5
H2-T10	-2083.5
Pik3r1	-1702.5
Btk	-1539.5
Shc1	-965.5
Syk	-526.5
Pik3r2	573.5
Vav3	1139.5
Rac1	2187.5
Grb2	2370.5
Pik3cb	3006.5
Vav2	3188.5
Hras	6386.5

---

POLYMERASE SWITCHING

set	POLYMERASE SWITCHING
setSize	14
pANOVA	0.013
s.dist	0.383
p.adjustANOVA	0.0563

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rfc3	7341.5
Pola1	6243.5
Prim2	5334.5
Pold3	5294.5
Pold2	5116.5
Pold4	4909.5
Pola2	3430.5
Prim1	3313.5
Pcna	3090.5
Rfc2	2532.5
Pold1	1891.5
Rfc1	-74.5
Rfc5	-218.5
Rfc4	-6295.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rfc3	7341.5
Pola1	6243.5
Prim2	5334.5
Pold3	5294.5
Pold2	5116.5
Pold4	4909.5
Pola2	3430.5
Prim1	3313.5
Pcna	3090.5
Rfc2	2532.5
Pold1	1891.5
Rfc1	-74.5
Rfc5	-218.5
Rfc4	-6295.5

---

PECAM1 INTERACTIONS

set	PECAM1 INTERACTIONS
setSize	11
pANOVA	0.0281
s.dist	-0.382
p.adjustANOVA	0.0983

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pecam1	-7344.5
Fyn	-6707.5
Inpp5d	-5772.5
Ptpn11	-5729.5
Itgav	-5394.5
Ptpn6	-4242.5
Plcg1	-2125.5
Lyn	-2030.5
Src	1121.5
Itgb3	1460.5
Yes1	5537.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pecam1	-7344.5
Fyn	-6707.5
Inpp5d	-5772.5
Ptpn11	-5729.5
Itgav	-5394.5
Ptpn6	-4242.5
Plcg1	-2125.5
Lyn	-2030.5
Src	1121.5
Itgb3	1460.5
Yes1	5537.5

---

COMPLEMENT CASCADE

set	COMPLEMENT CASCADE
setSize	26
pANOVA	0.00075
s.dist	-0.382
p.adjustANOVA	0.00587

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ighg2c	-6965.5
C1qa	-6889.5
C1qb	-6515.5
Colec11	-6475.5
Clu	-6416.5
C4b	-6210.5
Cfh	-6174.5
C5ar1	-5463.5
C8g	-5437.5
Masp1	-5327.5
Serping1	-5183.5
Vtn	-4954.5
C3	-4366.5
C1qc	-4208.5
C1ra	-3172.5
Gzmm	-2958.5
Fcna	-2526.5
C5ar2	-2332.5
Cd81	-1815.5
Cd55	-1174.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ighg2c	-6965.5
C1qa	-6889.5
C1qb	-6515.5
Colec11	-6475.5
Clu	-6416.5
C4b	-6210.5
Cfh	-6174.5
C5ar1	-5463.5
C8g	-5437.5
Masp1	-5327.5
Serping1	-5183.5
Vtn	-4954.5
C3	-4366.5
C1qc	-4208.5
C1ra	-3172.5
Gzmm	-2958.5
Fcna	-2526.5
C5ar2	-2332.5
Cd81	-1815.5
Cd55	-1174.5
C3ar1	-857.5
Cfp	901.5
C7	3423.5
Cfd	5336.5
Cd46	5498.5
Cd59b	6638.5

---

ISG15 ANTIVIRAL MECHANISM

set	ISG15 ANTIVIRAL MECHANISM
setSize	27
pANOVA	0.000594
s.dist	-0.382
p.adjustANOVA	0.00486

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Eif4a1	-7441.5
Becn1	-7158.5
Isg15	-7055.5
Eif4a3	-6735.5
Eif4g1	-6429.5
Flnb	-6271.5
Mapk3	-6090.5
Usp18	-5661.5
Eif4e2	-5479.5
Eif2ak2	-5417.5
Uba7	-4877.5
Mx2	-3763.5
Eif4a2	-3588.5
Ube2n	-3419.5
Eif4g3	-3366.5
Ube2e1	-3027.5
Ppm1b	-2705.5
Eif4e	-2675.5
Plcg1	-2125.5
Eif4g2	-1837.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Eif4a1	-7441.5
Becn1	-7158.5
Isg15	-7055.5
Eif4a3	-6735.5
Eif4g1	-6429.5
Flnb	-6271.5
Mapk3	-6090.5
Usp18	-5661.5
Eif4e2	-5479.5
Eif2ak2	-5417.5
Uba7	-4877.5
Mx2	-3763.5
Eif4a2	-3588.5
Ube2n	-3419.5
Eif4g3	-3366.5
Ube2e1	-3027.5
Ppm1b	-2705.5
Eif4e	-2675.5
Plcg1	-2125.5
Eif4g2	-1837.5
Irf3	444.5
Arih1	786.5
Nedd4	863.5
Eif4e3	2186.5
Trim25	2974.5
Ube2l6	4466.5
Ifit1bl2	6957.5

---

PURINE SALVAGE

set	PURINE SALVAGE
setSize	11
pANOVA	0.0298
s.dist	0.378
p.adjustANOVA	0.102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pnp	7194.5
Gmpr	6014.5
Adk	5729.5
Gmpr2	5515.5
Ampd3	5402.5
Adal	4712.5
Dguok	4273.5
Ada	259.5
Dck	-120.5
Aprt	-2519.5
Ampd2	-3931.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pnp	7194.5
Gmpr	6014.5
Adk	5729.5
Gmpr2	5515.5
Ampd3	5402.5
Adal	4712.5
Dguok	4273.5
Ada	259.5
Dck	-120.5
Aprt	-2519.5
Ampd2	-3931.5

---

G PROTEIN ACTIVATION

set	G PROTEIN ACTIVATION
setSize	15
pANOVA	0.0114
s.dist	-0.378
p.adjustANOVA	0.0511

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gnb3	-7271.5
Gna15	-6724.5
Gng2	-6040.5
Gnb2	-5980.5
Gnb1	-5643.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gna11	-4069.5
Gng11	-2501.5
Gngt2	-2002.5
Gnb4	992.5
Gng12	1547.5
Gnaq	3065.5
Gng5	6844.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gnb3	-7271.5
Gna15	-6724.5
Gng2	-6040.5
Gnb2	-5980.5
Gnb1	-5643.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gna11	-4069.5
Gng11	-2501.5
Gngt2	-2002.5
Gnb4	992.5
Gng12	1547.5
Gnaq	3065.5
Gng5	6844.5

---

SEMA3A PAK DEPENDENT AXON REPULSION

set	SEMA3A PAK DEPENDENT AXON REPULSION
setSize	14
pANOVA	0.0145
s.dist	-0.377
p.adjustANOVA	0.061

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pak2	-7076.5
Fyn	-6707.5
Pak1	-6577.5
Plxna2	-5871.5
Plxna3	-5640.5
Plxna4	-3855.5
Limk1	-3705.5
Fes	-3373.5
Nrp1	-1650.5
Plxna1	-922.5
Pak3	-489.5
Hsp90ab1	376.5
Rac1	2187.5
Hsp90aa1	4116.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pak2	-7076.5
Fyn	-6707.5
Pak1	-6577.5
Plxna2	-5871.5
Plxna3	-5640.5
Plxna4	-3855.5
Limk1	-3705.5
Fes	-3373.5
Nrp1	-1650.5
Plxna1	-922.5
Pak3	-489.5
Hsp90ab1	376.5
Rac1	2187.5
Hsp90aa1	4116.5

---

GLUTATHIONE SYNTHESIS AND RECYCLING

set	GLUTATHIONE SYNTHESIS AND RECYCLING
setSize	11
pANOVA	0.0315
s.dist	-0.374
p.adjustANOVA	0.107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ggt7	-7191.5
Cndp2	-7154.5
Oplah	-7012.5
Gss	-6375.5
Ggct	-4418.5
Chac2	-3355.5
Ggt5	-2836.5
Ggt1	26.5
Gclc	2191.5
Chac1	2445.5
Gclm	3122.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ggt7	-7191.5
Cndp2	-7154.5
Oplah	-7012.5
Gss	-6375.5
Ggct	-4418.5
Chac2	-3355.5
Ggt5	-2836.5
Ggt1	26.5
Gclc	2191.5
Chac1	2445.5
Gclm	3122.5

---

MITOCHONDRIAL CALCIUM ION TRANSPORT

set	MITOCHONDRIAL CALCIUM ION TRANSPORT
setSize	14
pANOVA	0.0159
s.dist	-0.372
p.adjustANOVA	0.0647

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Afg3l2	-7000.5
Parl	-6171.5
Micu2	-6055.5
Slc8b1	-5641.5
Phb2	-4789.5
Smdt1	-4649.5
Pmpcb	-3422.5
Pmpca	-3389.5
Spg7	-3268.5
Micu1	-2001.5
Mcu	-1773.5
Yme1l1	370.5
Stoml2	3785.5
Micu3	5347.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Afg3l2	-7000.5
Parl	-6171.5
Micu2	-6055.5
Slc8b1	-5641.5
Phb2	-4789.5
Smdt1	-4649.5
Pmpcb	-3422.5
Pmpca	-3389.5
Spg7	-3268.5
Micu1	-2001.5
Mcu	-1773.5
Yme1l1	370.5
Stoml2	3785.5
Micu3	5347.5

---

PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR

set	PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR
setSize	14
pANOVA	0.016
s.dist	-0.372
p.adjustANOVA	0.0647

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gnb3	-7271.5
Gng2	-6040.5
Gnb2	-5980.5
Gnb1	-5643.5
Ptgir	-5114.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gng11	-2501.5
Gngt2	-2002.5
Gnas	778.5
Gnb4	992.5
Gng12	1547.5
Gng5	6844.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gnb3	-7271.5
Gng2	-6040.5
Gnb2	-5980.5
Gnb1	-5643.5
Ptgir	-5114.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gng11	-2501.5
Gngt2	-2002.5
Gnas	778.5
Gnb4	992.5
Gng12	1547.5
Gng5	6844.5

---

G BETA GAMMA SIGNALLING THROUGH CDC42

set	G BETA GAMMA SIGNALLING THROUGH CDC42
setSize	15
pANOVA	0.0138
s.dist	-0.367
p.adjustANOVA	0.059

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gnb3	-7271.5
Pak1	-6577.5
Gng2	-6040.5
Gnb2	-5980.5
Gnb1	-5643.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gng11	-2501.5
Gngt2	-2002.5
Arhgef6	-665.5
Cdc42	707.5
Gnb4	992.5
Gng12	1547.5
Gng5	6844.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gnb3	-7271.5
Pak1	-6577.5
Gng2	-6040.5
Gnb2	-5980.5
Gnb1	-5643.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gng11	-2501.5
Gngt2	-2002.5
Arhgef6	-665.5
Cdc42	707.5
Gnb4	992.5
Gng12	1547.5
Gng5	6844.5

---

THROMBOXANE SIGNALLING THROUGH TP RECEPTOR

set	THROMBOXANE SIGNALLING THROUGH TP RECEPTOR
setSize	18
pANOVA	0.00701
s.dist	-0.367
p.adjustANOVA	0.0353

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gnb3	-7271.5
Gna15	-6724.5
Gng2	-6040.5
Gnb2	-5980.5
Aamp	-5851.5
Gnb1	-5643.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gna11	-4069.5
Tbxa2r	-2585.5
Gng11	-2501.5
Gngt2	-2002.5
Gnb4	992.5
Gna13	1477.5
Gng12	1547.5
Gnaq	3065.5
Gng5	6844.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gnb3	-7271.5
Gna15	-6724.5
Gng2	-6040.5
Gnb2	-5980.5
Aamp	-5851.5
Gnb1	-5643.5
Gnb5	-5104.5
Gng7	-4667.5
Gng8	-4453.5
Gna11	-4069.5
Tbxa2r	-2585.5
Gng11	-2501.5
Gngt2	-2002.5
Gnb4	992.5
Gna13	1477.5
Gng12	1547.5
Gnaq	3065.5
Gng5	6844.5

---

ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES

set	ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
setSize	42
pANOVA	4.11e-05
s.dist	-0.366
p.adjustANOVA	0.000661

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Col8a1	-7150.5
Col4a4	-7068.5
Col6a3	-7051.5
Loxl1	-7029.5
Col4a3	-6741.5
Col15a1	-6535.5
Col4a2	-6463.5
Ctsl	-6407.5
Col4a1	-6405.5
Mmp9	-6377.5
Col3a1	-6278.5
Col14a1	-6132.5
Tll2	-6088.5
Col18a1	-6067.5
Col6a1	-5925.5
Mmp3	-5725.5
Ctss	-5693.5
Col1a1	-5503.5
Col6a2	-4973.5
Col1a2	-4728.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Col8a1	-7150.5
Col4a4	-7068.5
Col6a3	-7051.5
Loxl1	-7029.5
Col4a3	-6741.5
Col15a1	-6535.5
Col4a2	-6463.5
Ctsl	-6407.5
Col4a1	-6405.5
Mmp9	-6377.5
Col3a1	-6278.5
Col14a1	-6132.5
Tll2	-6088.5
Col18a1	-6067.5
Col6a1	-5925.5
Mmp3	-5725.5
Ctss	-5693.5
Col1a1	-5503.5
Col6a2	-4973.5
Col1a2	-4728.5
Col5a1	-4525.5
Ctsb	-4315.5
Col5a2	-3971.5
Pcolce	-3839.5
Col9a2	-2728.5
Loxl3	-2393.5
Lox	-1869.5
Col5a3	-996.5
Bmp1	-833.5
Loxl2	-153.5
Loxl4	30.5
Col6a6	611.5
Mmp13	1424.5
Col4a6	1579.5
Tll1	2246.5
Col12a1	2711.5
Col11a1	4153.5
Col7a1	4161.5
Col4a5	4319.5
Col8a2	4475.5
Col11a2	4930.5
Pxdn	5676.5

---

INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE

set	INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
setSize	15
pANOVA	0.0152
s.dist	-0.362
p.adjustANOVA	0.0632

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Prnp	-7505.5
Sgta	-7056.5
Sec61g	-6107.5
Cyb5a	-4560.5
Stx1a	-4125.5
App	-3352.5
Sec61b	-2372.5
Vamp2	-2355.5
Serp1	-2311.5
Aldh3a2	-2274.5
Ube2j2	-1946.5
Vapa	164.5
Hmox1	297.5
Stx5a	1025.5
Emd	2230.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Prnp	-7505.5
Sgta	-7056.5
Sec61g	-6107.5
Cyb5a	-4560.5
Stx1a	-4125.5
App	-3352.5
Sec61b	-2372.5
Vamp2	-2355.5
Serp1	-2311.5
Aldh3a2	-2274.5
Ube2j2	-1946.5
Vapa	164.5
Hmox1	297.5
Stx5a	1025.5
Emd	2230.5

---

PLASMA LIPOPROTEIN ASSEMBLY

set	PLASMA LIPOPROTEIN ASSEMBLY
setSize	13
pANOVA	0.0255
s.dist	-0.358
p.adjustANOVA	0.0907

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Prkacb	-6782.5
A2m	-6508.5
Mttp	-5761.5
Sar1b	-5248.5
P4hb	-4929.5
Apoa1	-4036.5
Abca1	-3902.5
Apoe	-3490.5
Apob	-1811.5
Bmp1	-833.5
Prkaca	1203.5
Zdhhc8	2811.5
Apoa2	4829.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Prkacb	-6782.5
A2m	-6508.5
Mttp	-5761.5
Sar1b	-5248.5
P4hb	-4929.5
Apoa1	-4036.5
Abca1	-3902.5
Apoe	-3490.5
Apob	-1811.5
Bmp1	-833.5
Prkaca	1203.5
Zdhhc8	2811.5
Apoa2	4829.5

---

CELL EXTRACELLULAR MATRIX INTERACTIONS

set	CELL EXTRACELLULAR MATRIX INTERACTIONS
setSize	18
pANOVA	0.00866
s.dist	-0.357
p.adjustANOVA	0.0415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Actb	-6856.5
Vasp	-6586.5
Actn1	-6168.5
Flna	-5690.5
Flnc	-5004.5
Parva	-4799.5
Tesk1	-4601.5
Actg1	-3929.5
Fblim1	-3887.5
Parvb	-3810.5
Lims2	-3175.5
Rsu1	-1168.5
Itgb1	-1133.5
Ilk	-959.5
Arhgef6	-665.5
Lims1	1949.5
Fermt2	3043.5
Pxn	5801.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Actb	-6856.5
Vasp	-6586.5
Actn1	-6168.5
Flna	-5690.5
Flnc	-5004.5
Parva	-4799.5
Tesk1	-4601.5
Actg1	-3929.5
Fblim1	-3887.5
Parvb	-3810.5
Lims2	-3175.5
Rsu1	-1168.5
Itgb1	-1133.5
Ilk	-959.5
Arhgef6	-665.5
Lims1	1949.5
Fermt2	3043.5
Pxn	5801.5

---

ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC

set	ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC
setSize	26
pANOVA	0.00175
s.dist	-0.355
p.adjustANOVA	0.0118

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2-T23	-7213.5
H2-T22	-7126.5
Sec24d	-6688.5
H2-Q4	-6576.5
Erap1	-6551.5
Tap2	-6388.5
H2-K1	-6356.5
H2-Q6	-6315.5
B2m	-5962.5
Tapbp	-5917.5
H2-M3	-5646.5
Sar1b	-5248.5
H2-Q7	-5203.5
Sec24c	-2889.5
Tap1	-2689.5
Sec23a	-2114.5
H2-T10	-2083.5
Calr	-1710.5
Sec13	-1323.5
Pdia3	1124.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2-T23	-7213.5
H2-T22	-7126.5
Sec24d	-6688.5
H2-Q4	-6576.5
Erap1	-6551.5
Tap2	-6388.5
H2-K1	-6356.5
H2-Q6	-6315.5
B2m	-5962.5
Tapbp	-5917.5
H2-M3	-5646.5
Sar1b	-5248.5
H2-Q7	-5203.5
Sec24c	-2889.5
Tap1	-2689.5
Sec23a	-2114.5
H2-T10	-2083.5
Calr	-1710.5
Sec13	-1323.5
Pdia3	1124.5
Bcap31	1451.5
Hspa5	2762.5
Sec31a	4430.5
Canx	4472.5
Sec24a	4744.5
Sec24b	6793.5

---

METALLOPROTEASE DUBS

set	METALLOPROTEASE DUBS
setSize	17
pANOVA	0.0116
s.dist	0.354
p.adjustANOVA	0.0517

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ubc	7553.5
Stambp	7053.5
Bard1	6804.5
Mysm1	6713.5
Brcc3	5654.5
Babam1	3897.5
Uimc1	3803.5
Ep300	3799.5
Uba52	2997.5
Stam	2918.5
Stambpl1	2505.5
Brca1	1656.5
Kat2b	1233.5
Rps27a	393.5
Ubb	-214.5
Psmd14	-2762.5
Nlrp3	-6943.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ubc	7553.5
Stambp	7053.5
Bard1	6804.5
Mysm1	6713.5
Brcc3	5654.5
Babam1	3897.5
Uimc1	3803.5
Ep300	3799.5
Uba52	2997.5
Stam	2918.5
Stambpl1	2505.5
Brca1	1656.5
Kat2b	1233.5
Rps27a	393.5
Ubb	-214.5
Psmd14	-2762.5
Nlrp3	-6943.5

---

ANTIMICROBIAL PEPTIDES

set	ANTIMICROBIAL PEPTIDES
setSize	11
pANOVA	0.0426
s.dist	-0.353
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Lcn2	-7270.5
Tlr2	-6950.5
Clu	-6416.5
Art1	-5793.5
Cd4	-4891.5
Lyz2	-4769.5
Slc11a1	-2316.5
Atp7a	-2173.5
Atox1	1958.5
Pdzd11	4456.5
Tlr1	5404.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Lcn2	-7270.5
Tlr2	-6950.5
Clu	-6416.5
Art1	-5793.5
Cd4	-4891.5
Lyz2	-4769.5
Slc11a1	-2316.5
Atp7a	-2173.5
Atox1	1958.5
Pdzd11	4456.5
Tlr1	5404.5

---

NUCLEAR SIGNALING BY ERBB4

set	NUCLEAR SIGNALING BY ERBB4
setSize	11
pANOVA	0.0429
s.dist	0.353
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Erbb4	7539.5
Wwox	5797.5
Ncstn	5785.5
Psenen	3233.5
Esr1	2808.5
Psen1	2372.5
Aph1b	2248.5
Yap1	2046.5
Src	1121.5
Stat5a	745.5
Aph1a	-3332.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Erbb4	7539.5
Wwox	5797.5
Ncstn	5785.5
Psenen	3233.5
Esr1	2808.5
Psen1	2372.5
Aph1b	2248.5
Yap1	2046.5
Src	1121.5
Stat5a	745.5
Aph1a	-3332.5

---

POST NMDA RECEPTOR ACTIVATION EVENTS

set	POST NMDA RECEPTOR ACTIVATION EVENTS
setSize	14
pANOVA	0.0226
s.dist	-0.352
p.adjustANOVA	0.0825

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Camk1	-7527.5
Rps6ka2	-7332.5
Prkacb	-6782.5
Prkar1a	-6555.5
Calm1	-5300.5
Rps6ka1	-4313.5
Camkk2	-4130.5
Camkk1	-3652.5
Prkar1b	-2116.5
Calm2	-1804.5
Prkaca	1203.5
Rps6ka3	1594.5
Calm3	3520.5
Creb1	6716.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Camk1	-7527.5
Rps6ka2	-7332.5
Prkacb	-6782.5
Prkar1a	-6555.5
Calm1	-5300.5
Rps6ka1	-4313.5
Camkk2	-4130.5
Camkk1	-3652.5
Prkar1b	-2116.5
Calm2	-1804.5
Prkaca	1203.5
Rps6ka3	1594.5
Calm3	3520.5
Creb1	6716.5

---

HS GAG BIOSYNTHESIS

set	HS GAG BIOSYNTHESIS
setSize	21
pANOVA	0.00551
s.dist	-0.35
p.adjustANOVA	0.0295

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sdc4	-7387.5
Gpc4	-6064.5
Agrn	-5940.5
Sdc3	-5505.5
Hs6st2	-5475.5
Gpc3	-5345.5
Gpc6	-5130.5
Sdc1	-4854.5
Ext2	-4544.5
Hs3st3b1	-4112.5
Ndst2	-2847.5
Hs6st1	-2511.5
Hs3st1	-1942.5
Hs2st1	-1312.5
Sdc2	-1162.5
Ext1	-854.5
Gpc1	-580.5
Slc35d2	-194.5
Ndst1	815.5
Hs3st5	3948.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sdc4	-7387.5
Gpc4	-6064.5
Agrn	-5940.5
Sdc3	-5505.5
Hs6st2	-5475.5
Gpc3	-5345.5
Gpc6	-5130.5
Sdc1	-4854.5
Ext2	-4544.5
Hs3st3b1	-4112.5
Ndst2	-2847.5
Hs6st1	-2511.5
Hs3st1	-1942.5
Hs2st1	-1312.5
Sdc2	-1162.5
Ext1	-854.5
Gpc1	-580.5
Slc35d2	-194.5
Ndst1	815.5
Hs3st5	3948.5
Hs3st3a1	6634.5

---

GAP JUNCTION ASSEMBLY

set	GAP JUNCTION ASSEMBLY
setSize	18
pANOVA	0.0111
s.dist	-0.346
p.adjustANOVA	0.0507

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Tuba1c	-7096.5
Tubb2a	-6882.5
Gja4	-6369.5
Tubb4b	-6105.5
Tubb2b	-4674.5
Tubb6	-3718.5
Tubb3	-3146.5
Gjc2	-3034.5
Gja3	-2860.5
Tuba1a	-2322.5
Gjc1	-1971.5
Gja5	-1123.5
Tuba1b	-702.5
Tuba8	-294.5
Tubb4a	216.5
Gja1	501.5
Tubb1	958.5
Tuba4a	2589.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Tuba1c	-7096.5
Tubb2a	-6882.5
Gja4	-6369.5
Tubb4b	-6105.5
Tubb2b	-4674.5
Tubb6	-3718.5
Tubb3	-3146.5
Gjc2	-3034.5
Gja3	-2860.5
Tuba1a	-2322.5
Gjc1	-1971.5
Gja5	-1123.5
Tuba1b	-702.5
Tuba8	-294.5
Tubb4a	216.5
Gja1	501.5
Tubb1	958.5
Tuba4a	2589.5

---

DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING

set	DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING
setSize	54
pANOVA	1.21e-05
s.dist	-0.344
p.adjustANOVA	0.00028

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	-7546.5
Nfkb2	-7342.5
Psmc1	-7288.5
Psmd10	-7064.5
Psme2	-7040.5
Psmb10	-6939.5
Relb	-6606.5
Psmc4	-6549.5
Psma5	-6525.5
Psmd2	-6327.5
Psme1	-6257.5
Psmd1	-6039.5
Psmd11	-5965.5
Psma2	-5618.5
Psmb8	-5467.5
Psmd8	-5359.5
Psmd7	-5325.5
Map3k14	-5202.5
Uba3	-5180.5
Psmc5	-5161.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	-7546.5
Nfkb2	-7342.5
Psmc1	-7288.5
Psmd10	-7064.5
Psme2	-7040.5
Psmb10	-6939.5
Relb	-6606.5
Psmc4	-6549.5
Psma5	-6525.5
Psmd2	-6327.5
Psme1	-6257.5
Psmd1	-6039.5
Psmd11	-5965.5
Psma2	-5618.5
Psmb8	-5467.5
Psmd8	-5359.5
Psmd7	-5325.5
Map3k14	-5202.5
Uba3	-5180.5
Psmc5	-5161.5
Psmd6	-4829.5
Psme3	-4691.5
Psmc2	-4540.5
Psmb1	-4379.5
Psmd13	-3886.5
Psmd3	-3817.5
Psmd4	-3794.5
Psmd12	-3563.5
Psmb4	-3183.5
Psmd14	-2762.5
Psma4	-2352.5
Psmb2	-1497.5
Psma7	-1409.5
Psma1	-1280.5
Psmd5	-1273.5
Psmb7	-1206.5
Psma6	-877.5
Cul1	-595.5
Ubb	-214.5
Psmc3	-9.5
Rps27a	393.5
Psmc6	483.5
Psmd9	1293.5
Psme4	1297.5
Psmb6	1690.5
Chuk	2101.5
Psme2b	2110.5
Psmb3	2137.5
Psma3	2596.5
Uba52	2997.5
Fbxw11	3782.5
Ube2m	4607.5
Psmf1	4753.5
Ubc	7553.5

---

PLATELET SENSITIZATION BY LDL

set	PLATELET SENSITIZATION BY LDL
setSize	16
pANOVA	0.0173
s.dist	-0.344
p.adjustANOVA	0.0678

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pecam1	-7344.5
Pla2g4a	-7001.5
Ptpn11	-5729.5
Ppp2r5c	-5392.5
Ptpn6	-4242.5
Ppp2r5b	-4195.5
Ppp2r5e	-3405.5
Ppp2r1a	-3274.5
Mapk14	-3091.5
Ppp2ca	-2486.5
Apob	-1811.5
Ppp2r1b	-736.5
Ppp2r5a	677.5
Lrp8	1268.5
Ppp2cb	2706.5
Ppp2r5d	3358.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pecam1	-7344.5
Pla2g4a	-7001.5
Ptpn11	-5729.5
Ppp2r5c	-5392.5
Ptpn6	-4242.5
Ppp2r5b	-4195.5
Ppp2r5e	-3405.5
Ppp2r1a	-3274.5
Mapk14	-3091.5
Ppp2ca	-2486.5
Apob	-1811.5
Ppp2r1b	-736.5
Ppp2r5a	677.5
Lrp8	1268.5
Ppp2cb	2706.5
Ppp2r5d	3358.5

---

PROCESSIVE SYNTHESIS ON THE LAGGING STRAND

set	PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
setSize	15
pANOVA	0.0212
s.dist	0.344
p.adjustANOVA	0.079

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Lig1	6952.5
Pola1	6243.5
Prim2	5334.5
Pold3	5294.5
Pold2	5116.5
Pold4	4909.5
Pola2	3430.5
Prim1	3313.5
Pcna	3090.5
Pold1	1891.5
Dna2	1613.5
Rpa2	1118.5
Rpa3	-455.5
Rpa1	-3196.5
Fen1	-4270.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Lig1	6952.5
Pola1	6243.5
Prim2	5334.5
Pold3	5294.5
Pold2	5116.5
Pold4	4909.5
Pola2	3430.5
Prim1	3313.5
Pcna	3090.5
Pold1	1891.5
Dna2	1613.5
Rpa2	1118.5
Rpa3	-455.5
Rpa1	-3196.5
Fen1	-4270.5

---

NON INTEGRIN MEMBRANE ECM INTERACTIONS

set	NON INTEGRIN MEMBRANE ECM INTERACTIONS
setSize	30
pANOVA	0.00116
s.dist	-0.343
p.adjustANOVA	0.00853

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sdc4	-7387.5
Col4a4	-7068.5
Col4a3	-6741.5
Col4a2	-6463.5
Col4a1	-6405.5
Col3a1	-6278.5
Ddr2	-5781.5
Sdc3	-5505.5
Col1a1	-5503.5
Itgav	-5394.5
Vtn	-4954.5
Sdc1	-4854.5
Col1a2	-4728.5
Fn1	-4709.5
Col5a1	-4525.5
Itga6	-3992.5
Col5a2	-3971.5
Sdc2	-1162.5
Itgb1	-1133.5
Col5a3	-996.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sdc4	-7387.5
Col4a4	-7068.5
Col4a3	-6741.5
Col4a2	-6463.5
Col4a1	-6405.5
Col3a1	-6278.5
Ddr2	-5781.5
Sdc3	-5505.5
Col1a1	-5503.5
Itgav	-5394.5
Vtn	-4954.5
Sdc1	-4854.5
Col1a2	-4728.5
Fn1	-4709.5
Col5a1	-4525.5
Itga6	-3992.5
Col5a2	-3971.5
Sdc2	-1162.5
Itgb1	-1133.5
Col5a3	-996.5
Tgfb1	-683.5
Ddr1	-449.5
Fgf2	-75.5
Itgb4	264.5
Itgb3	1460.5
Col4a6	1579.5
Col11a1	4153.5
Col4a5	4319.5
Col11a2	4930.5
Itga2	6056.5

---

CA DEPENDENT EVENTS

set	CA DEPENDENT EVENTS
setSize	25
pANOVA	0.00304
s.dist	-0.342
p.adjustANOVA	0.0187

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy1	-7011.5
Pla2g4a	-7001.5
Prkacb	-6782.5
Prkcd	-6578.5
Prkar1a	-6555.5
Calm1	-5300.5
Adcy4	-5186.5
Adcy2	-4851.5
Adcy7	-4317.5
Adcy5	-4189.5
Camkk2	-4130.5
Adcy9	-3875.5
Camkk1	-3652.5
Pde1b	-2988.5
Pde1c	-2222.5
Prkar1b	-2116.5
Adcy3	-2034.5
Calm2	-1804.5
Pde1a	-1600.5
Prkcg	-751.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy1	-7011.5
Pla2g4a	-7001.5
Prkacb	-6782.5
Prkcd	-6578.5
Prkar1a	-6555.5
Calm1	-5300.5
Adcy4	-5186.5
Adcy2	-4851.5
Adcy7	-4317.5
Adcy5	-4189.5
Camkk2	-4130.5
Adcy9	-3875.5
Camkk1	-3652.5
Pde1b	-2988.5
Pde1c	-2222.5
Prkar1b	-2116.5
Adcy3	-2034.5
Calm2	-1804.5
Pde1a	-1600.5
Prkcg	-751.5
Prkaca	1203.5
Adcy6	2202.5
Calm3	3520.5
Mapk1	5380.5
Adcy8	7354.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] kableExtra_1.4.0 pkgload_1.4.0    GGally_2.2.1     ggplot2_3.5.1   
##  [5] reshape2_1.4.4   beeswarm_0.4.0   gplots_3.2.0     gtools_3.9.5    
##  [9] tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5  mitch_1.17.4    
## 
## loaded via a namespace (and not attached):
##  [1] sass_0.4.9         utf8_1.2.4         generics_0.1.3     tidyr_1.3.1       
##  [5] bitops_1.0-9       xml2_1.3.6         KernSmooth_2.23-24 stringi_1.8.4     
##  [9] caTools_1.18.3     digest_0.6.37      magrittr_2.0.3     evaluate_1.0.1    
## [13] grid_4.4.1         RColorBrewer_1.1-3 fastmap_1.2.0      plyr_1.8.9        
## [17] jsonlite_1.8.9     gridExtra_2.3      promises_1.3.0     purrr_1.0.2       
## [21] fansi_1.0.6        viridisLite_0.4.2  scales_1.3.0       jquerylib_0.1.4   
## [25] cli_3.6.3          shiny_1.9.1        rlang_1.1.4        munsell_0.5.1     
## [29] withr_3.0.1        cachem_1.1.0       yaml_2.3.10        parallel_4.4.1    
## [33] tools_4.4.1        colorspace_2.1-1   httpuv_1.6.15      ggstats_0.7.0     
## [37] vctrs_0.6.5        R6_2.5.1           mime_0.12          lifecycle_1.0.4   
## [41] stringr_1.5.1      htmlwidgets_1.6.4  MASS_7.3-61        pkgconfig_2.0.3   
## [45] pillar_1.9.0       bslib_0.8.0        later_1.3.2        gtable_0.3.5      
## [49] glue_1.8.0         Rcpp_1.0.13        systemfonts_1.1.0  highr_0.11        
## [53] xfun_0.48          tidyselect_1.2.1   rstudioapi_0.17.1  knitr_1.48        
## [57] xtable_1.8-4       htmltools_0.5.8.1  rmarkdown_2.28     svglite_2.1.3     
## [61] compiler_4.4.1

END of report