date generated: 2024-10-24

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610007P14Rik -0.3486404
0610009B22Rik -13.7043137
0610009E02Rik -0.0834285
0610009L18Rik -3.3723116
0610009O20Rik -135.7937142
0610010F05Rik 0.2881691

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1289
num_genes_in_profile 15245
duplicated_genes_present 0
num_profile_genes_in_sets 6763
num_profile_genes_not_in_sets 8482

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1289
num_genesets_excluded 389
num_genesets_included 900

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
COMPLEX I BIOGENESIS 58 5.55e-33 -0.907 9.99e-31
CITRIC ACID CYCLE TCA CYCLE 33 1.14e-18 -0.886 1.14e-16
BRANCHED CHAIN AMINO ACID CATABOLISM 20 7.67e-12 -0.884 3.83e-10
UBIQUINOL BIOSYNTHESIS 11 5.03e-07 -0.875 1.10e-05
PROTEIN LIPOYLATION 10 2.80e-06 -0.855 5.61e-05
RESPIRATORY ELECTRON TRANSPORT 124 1.76e-59 -0.843 7.93e-57
COMPLEX III ASSEMBLY 17 3.21e-09 -0.829 1.03e-07
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE 18 1.12e-09 -0.829 3.73e-08
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.49e-16 -0.824 2.04e-14
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT 202 3.09e-83 -0.786 2.78e-80
MITOCHONDRIAL TRANSLATION 87 3.76e-36 -0.777 8.46e-34
MITOCHONDRIAL PROTEIN DEGRADATION 70 2.72e-28 -0.761 4.08e-26
MITOCHONDRIAL BIOGENESIS 10 5.36e-05 -0.738 8.05e-04
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 10 5.36e-05 -0.738 8.05e-04
COLLAGEN CHAIN TRIMERIZATION 34 1.31e-13 0.733 7.39e-12
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 10 6.33e-05 -0.730 9.34e-04
COMPLEX IV ASSEMBLY 38 3.85e-14 -0.709 2.31e-12
CROSSLINKING OF COLLAGEN FIBRILS 18 3.64e-07 0.692 8.18e-06
HEME BIOSYNTHESIS 12 4.34e-05 -0.682 6.73e-04
MET ACTIVATES PTK2 SIGNALING 18 5.66e-07 0.681 1.21e-05
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 14 1.08e-05 -0.679 2.03e-04
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 1.18e-04 -0.670 1.66e-03
CS DS DEGRADATION 11 1.18e-04 0.670 1.66e-03
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 53 9.90e-17 0.659 8.91e-15
LAMININ INTERACTIONS 15 1.42e-05 0.647 2.56e-04
ECM PROTEOGLYCANS 35 4.73e-11 0.642 1.93e-09
METABOLISM OF COFACTORS 23 2.35e-07 -0.623 5.56e-06
KERATAN SULFATE DEGRADATION 12 2.00e-04 0.620 2.57e-03
NCAM1 INTERACTIONS 16 1.80e-05 0.619 3.11e-04
NON INTEGRIN MEMBRANE ECM INTERACTIONS 30 6.50e-09 0.612 2.02e-07
CHONDROITIN SULFATE BIOSYNTHESIS 16 2.27e-05 0.612 3.72e-04
ELASTIC FIBRE FORMATION 36 2.34e-10 0.610 8.42e-09
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 42 1.45e-11 0.602 6.89e-10
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 10 1.33e-03 -0.586 1.30e-02
COLLAGEN FORMATION 65 3.06e-16 0.586 2.29e-14
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 29 5.33e-08 0.584 1.43e-06
DISSOLUTION OF FIBRIN CLOT 10 1.56e-03 0.578 1.48e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 10 1.78e-03 0.571 1.65e-02
PYRUVATE METABOLISM 42 1.71e-10 -0.569 6.68e-09
CARNITINE METABOLISM 14 2.39e-04 -0.567 2.90e-03
PEROXISOMAL PROTEIN IMPORT 61 2.03e-14 -0.566 1.30e-12
REGULATION OF PYRUVATE METABOLISM 32 5.38e-08 -0.555 1.43e-06
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 14 3.27e-04 -0.555 3.67e-03
ENDOSOMAL VACUOLAR PATHWAY 10 2.60e-03 0.550 2.23e-02
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 11 2.36e-03 0.529 2.08e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 18 1.29e-04 -0.521 1.76e-03
COLLAGEN DEGRADATION 39 5.60e-08 0.503 1.44e-06
CYTOPROTECTION BY HMOX1 44 1.60e-08 -0.492 4.79e-07
SULFUR AMINO ACID METABOLISM 19 2.34e-04 -0.488 2.88e-03
METABOLISM OF PORPHYRINS 21 1.29e-04 -0.483 1.76e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
COMPLEX I BIOGENESIS 58 5.55e-33 -9.07e-01 9.99e-31
CITRIC ACID CYCLE TCA CYCLE 33 1.14e-18 -8.86e-01 1.14e-16
BRANCHED CHAIN AMINO ACID CATABOLISM 20 7.67e-12 -8.84e-01 3.83e-10
UBIQUINOL BIOSYNTHESIS 11 5.03e-07 -8.75e-01 1.10e-05
PROTEIN LIPOYLATION 10 2.80e-06 -8.55e-01 5.61e-05
RESPIRATORY ELECTRON TRANSPORT 124 1.76e-59 -8.43e-01 7.93e-57
COMPLEX III ASSEMBLY 17 3.21e-09 -8.29e-01 1.03e-07
MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE 18 1.12e-09 -8.29e-01 3.73e-08
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.49e-16 -8.24e-01 2.04e-14
AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT 202 3.09e-83 -7.86e-01 2.78e-80
MITOCHONDRIAL TRANSLATION 87 3.76e-36 -7.77e-01 8.46e-34
MITOCHONDRIAL PROTEIN DEGRADATION 70 2.72e-28 -7.61e-01 4.08e-26
MITOCHONDRIAL BIOGENESIS 10 5.36e-05 -7.38e-01 8.05e-04
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 10 5.36e-05 -7.38e-01 8.05e-04
COLLAGEN CHAIN TRIMERIZATION 34 1.31e-13 7.33e-01 7.39e-12
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 10 6.33e-05 -7.30e-01 9.34e-04
COMPLEX IV ASSEMBLY 38 3.85e-14 -7.09e-01 2.31e-12
CROSSLINKING OF COLLAGEN FIBRILS 18 3.64e-07 6.92e-01 8.18e-06
HEME BIOSYNTHESIS 12 4.34e-05 -6.82e-01 6.73e-04
MET ACTIVATES PTK2 SIGNALING 18 5.66e-07 6.81e-01 1.21e-05
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 14 1.08e-05 -6.79e-01 2.03e-04
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 1.18e-04 -6.70e-01 1.66e-03
CS DS DEGRADATION 11 1.18e-04 6.70e-01 1.66e-03
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 53 9.90e-17 6.59e-01 8.91e-15
LAMININ INTERACTIONS 15 1.42e-05 6.47e-01 2.56e-04
ECM PROTEOGLYCANS 35 4.73e-11 6.42e-01 1.93e-09
METABOLISM OF COFACTORS 23 2.35e-07 -6.23e-01 5.56e-06
KERATAN SULFATE DEGRADATION 12 2.00e-04 6.20e-01 2.57e-03
NCAM1 INTERACTIONS 16 1.80e-05 6.19e-01 3.11e-04
NON INTEGRIN MEMBRANE ECM INTERACTIONS 30 6.50e-09 6.12e-01 2.02e-07
CHONDROITIN SULFATE BIOSYNTHESIS 16 2.27e-05 6.12e-01 3.72e-04
ELASTIC FIBRE FORMATION 36 2.34e-10 6.10e-01 8.42e-09
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 42 1.45e-11 6.02e-01 6.89e-10
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 10 1.33e-03 -5.86e-01 1.30e-02
COLLAGEN FORMATION 65 3.06e-16 5.86e-01 2.29e-14
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 29 5.33e-08 5.84e-01 1.43e-06
DISSOLUTION OF FIBRIN CLOT 10 1.56e-03 5.78e-01 1.48e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 10 1.78e-03 5.71e-01 1.65e-02
PYRUVATE METABOLISM 42 1.71e-10 -5.69e-01 6.68e-09
CARNITINE METABOLISM 14 2.39e-04 -5.67e-01 2.90e-03
PEROXISOMAL PROTEIN IMPORT 61 2.03e-14 -5.66e-01 1.30e-12
REGULATION OF PYRUVATE METABOLISM 32 5.38e-08 -5.55e-01 1.43e-06
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 14 3.27e-04 -5.55e-01 3.67e-03
ENDOSOMAL VACUOLAR PATHWAY 10 2.60e-03 5.50e-01 2.23e-02
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 11 2.36e-03 5.29e-01 2.08e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 18 1.29e-04 -5.21e-01 1.76e-03
COLLAGEN DEGRADATION 39 5.60e-08 5.03e-01 1.44e-06
CYTOPROTECTION BY HMOX1 44 1.60e-08 -4.92e-01 4.79e-07
SULFUR AMINO ACID METABOLISM 19 2.34e-04 -4.88e-01 2.88e-03
METABOLISM OF PORPHYRINS 21 1.29e-04 -4.83e-01 1.76e-03
REPRODUCTION 11 5.93e-03 4.79e-01 4.27e-02
PROTEIN LOCALIZATION 95 9.60e-16 -4.77e-01 6.65e-14
INTEGRIN CELL SURFACE INTERACTIONS 65 3.14e-11 4.76e-01 1.34e-09
MET PROMOTES CELL MOTILITY 28 1.37e-05 4.75e-01 2.51e-04
HYALURONAN UPTAKE AND DEGRADATION 11 6.51e-03 4.74e-01 4.47e-02
PEROXISOMAL LIPID METABOLISM 27 2.23e-05 -4.72e-01 3.71e-04
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 11 7.03e-03 4.69e-01 4.75e-02
EXTRACELLULAR MATRIX ORGANIZATION 191 8.54e-28 4.59e-01 1.10e-25
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 16 1.67e-03 4.54e-01 1.56e-02
ACTIVATION OF SMO 10 1.33e-02 4.52e-01 7.98e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 40 8.46e-07 4.50e-01 1.77e-05
PINK1 PRKN MEDIATED MITOPHAGY 30 2.02e-05 -4.50e-01 3.44e-04
MITOPHAGY 37 3.31e-06 -4.42e-01 6.47e-05
VITAMIN B5 PANTOTHENATE METABOLISM 14 4.40e-03 -4.40e-01 3.51e-02
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 14 5.40e-03 4.30e-01 3.98e-02
BIOTIN TRANSPORT AND METABOLISM 11 1.50e-02 -4.23e-01 8.63e-02
RECEPTOR MEDIATED MITOPHAGY 11 1.51e-02 -4.23e-01 8.63e-02
SYNDECAN INTERACTIONS 14 6.59e-03 4.19e-01 4.50e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX 79 2.28e-10 4.13e-01 8.42e-09
GROWTH HORMONE RECEPTOR SIGNALING 10 2.53e-02 -4.09e-01 1.27e-01
TRANSLATION 218 4.98e-25 -4.06e-01 5.60e-23
LYSINE CATABOLISM 10 2.82e-02 -4.01e-01 1.34e-01
HYALURONAN METABOLISM 14 9.98e-03 3.98e-01 6.37e-02
REGULATION OF LIPID METABOLISM BY PPARALPHA 16 6.12e-03 -3.96e-01 4.34e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 1.35e-02 -3.96e-01 8.04e-02
GLUCONEOGENESIS 19 2.95e-03 -3.94e-01 2.46e-02
SIGNALING BY BMP 23 1.31e-03 3.87e-01 1.30e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 14 1.28e-02 -3.84e-01 7.73e-02
TRIGLYCERIDE METABOLISM 12 2.15e-02 -3.83e-01 1.12e-01
INTERLEUKIN 15 SIGNALING 10 3.59e-02 -3.83e-01 1.57e-01
TP53 REGULATES METABOLIC GENES 66 1.21e-07 -3.77e-01 2.95e-06
AFLATOXIN ACTIVATION AND DETOXIFICATION 10 4.56e-02 -3.65e-01 1.82e-01
FATTY ACID METABOLISM 133 4.72e-13 -3.63e-01 2.50e-11
MTORC1 MEDIATED SIGNALLING 24 2.06e-03 -3.63e-01 1.88e-02
SIGNALING BY TGFBR3 21 4.16e-03 3.61e-01 3.34e-02
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 4.86e-02 -3.60e-01 1.88e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 34 2.82e-04 3.60e-01 3.25e-03
SIGNALING BY HIPPO 20 6.04e-03 3.55e-01 4.31e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 83 2.63e-08 3.53e-01 7.63e-07
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 13 2.86e-02 -3.51e-01 1.36e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 5.68e-02 -3.48e-01 2.10e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 3.84e-02 3.45e-01 1.60e-01
JOSEPHIN DOMAIN DUBS 10 6.08e-02 -3.42e-01 2.19e-01
SYNTHESIS OF PA 25 3.18e-03 -3.41e-01 2.62e-02
ER PHAGOSOME PATHWAY 19 1.01e-02 3.41e-01 6.38e-02
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 37 3.75e-04 3.38e-01 4.12e-03
FRS MEDIATED FGFR4 SIGNALING 13 3.51e-02 -3.38e-01 1.56e-01
FRS MEDIATED FGFR3 SIGNALING 13 3.51e-02 -3.38e-01 1.56e-01
REGULATION OF FZD BY UBIQUITINATION 13 3.57e-02 -3.36e-01 1.57e-01
REGULATION OF PTEN GENE TRANSCRIPTION 27 2.51e-03 -3.36e-01 2.18e-02
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 14 2.97e-02 3.36e-01 1.38e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 10 6.69e-02 -3.35e-01 2.32e-01
INTRAFLAGELLAR TRANSPORT 40 2.60e-04 3.34e-01 3.08e-03
PI 3K CASCADE FGFR4 12 4.57e-02 -3.33e-01 1.82e-01
PI 3K CASCADE FGFR3 12 4.57e-02 -3.33e-01 1.82e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 18 1.45e-02 3.33e-01 8.43e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 1.54e-02 3.30e-01 8.63e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 11 6.23e-02 3.25e-01 2.23e-01
OTHER INTERLEUKIN SIGNALING 14 3.55e-02 3.25e-01 1.57e-01
FRS MEDIATED FGFR2 SIGNALING 14 3.59e-02 -3.24e-01 1.57e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 11 6.38e-02 3.23e-01 2.26e-01
GLYCOSAMINOGLYCAN METABOLISM 98 4.18e-08 3.21e-01 1.18e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 3.80e-02 -3.20e-01 1.59e-01
KINESINS 47 1.52e-04 3.19e-01 2.01e-03
PI 3K CASCADE FGFR2 13 4.66e-02 -3.19e-01 1.84e-01
SIGNALING BY RETINOIC ACID 34 1.33e-03 -3.18e-01 1.30e-02
GLYCOGEN METABOLISM 17 2.54e-02 -3.13e-01 1.27e-01
SIGNALING BY PDGF 50 1.32e-04 3.13e-01 1.77e-03
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 8.76e-02 -3.12e-01 2.66e-01
KERATAN SULFATE KERATIN METABOLISM 28 4.51e-03 3.10e-01 3.56e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 19 1.94e-02 3.10e-01 1.03e-01
NUCLEOTIDE BIOSYNTHESIS 12 6.67e-02 -3.06e-01 2.32e-01
P75NTR SIGNALS VIA NF KB 16 3.77e-02 3.00e-01 1.59e-01
AGGREPHAGY 28 6.25e-03 2.99e-01 4.39e-02
MTOR SIGNALLING 41 9.90e-04 -2.97e-01 1.01e-02
TGFBR3 PTM REGULATION 10 1.04e-01 2.97e-01 2.97e-01
HATS ACETYLATE HISTONES 29 5.65e-03 -2.97e-01 4.10e-02
SEMA4D IN SEMAPHORIN SIGNALING 15 4.71e-02 2.96e-01 1.84e-01
PLATELET AGGREGATION PLUG FORMATION 30 5.48e-03 2.93e-01 4.01e-02
ACTIVATION OF MATRIX METALLOPROTEINASES 19 2.75e-02 2.92e-01 1.32e-01
SHC1 EVENTS IN ERBB2 SIGNALING 13 6.94e-02 2.91e-01 2.36e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 1.63e-02 2.89e-01 8.94e-02
DARPP 32 EVENTS 15 5.49e-02 -2.86e-01 2.05e-01
VOLTAGE GATED POTASSIUM CHANNELS 21 2.37e-02 -2.85e-01 1.20e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 3.78e-02 -2.83e-01 1.59e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 18 3.78e-02 -2.83e-01 1.59e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 86 6.48e-06 -2.82e-01 1.24e-04
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 14 6.96e-02 2.80e-01 2.36e-01
INFLAMMASOMES 12 9.33e-02 2.80e-01 2.76e-01
TRAF6 MEDIATED NF KB ACTIVATION 13 8.12e-02 2.79e-01 2.56e-01
CRMPS IN SEMA3A SIGNALING 14 7.12e-02 2.79e-01 2.39e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 34 4.97e-03 2.78e-01 3.76e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 19 3.75e-02 -2.76e-01 1.59e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 29 1.02e-02 -2.76e-01 6.38e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 30 9.55e-03 -2.73e-01 6.14e-02
NR1H2 AND NR1H3 MEDIATED SIGNALING 12 1.06e-01 -2.69e-01 3.02e-01
GLYCOSPHINGOLIPID BIOSYNTHESIS 14 8.16e-02 2.69e-01 2.57e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 2.93e-02 -2.69e-01 1.38e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 10 1.43e-01 2.67e-01 3.68e-01
INTEGRIN SIGNALING 26 1.93e-02 2.65e-01 1.03e-01
KERATAN SULFATE BIOSYNTHESIS 21 3.64e-02 2.64e-01 1.58e-01
SIGNALING BY ALK 14 8.81e-02 2.63e-01 2.67e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 187 7.08e-10 -2.62e-01 2.45e-08
CELLULAR RESPONSE TO CHEMICAL STRESS 145 8.17e-08 -2.58e-01 2.04e-06
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 11 1.42e-01 -2.56e-01 3.67e-01
GAP JUNCTION TRAFFICKING AND REGULATION 30 1.55e-02 2.55e-01 8.63e-02
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 1.62e-01 -2.55e-01 3.86e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 41 4.72e-03 2.55e-01 3.60e-02
GAP JUNCTION ASSEMBLY 18 6.19e-02 2.54e-01 2.22e-01
PROCESSING OF INTRONLESS PRE MRNAS 20 4.97e-02 -2.54e-01 1.90e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 1.18e-01 2.50e-01 3.23e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 10 1.71e-01 -2.50e-01 3.99e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.71e-03 -2.49e-01 3.60e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 17 7.58e-02 -2.49e-01 2.47e-01
RUNX3 REGULATES NOTCH SIGNALING 10 1.74e-01 2.49e-01 4.04e-01
DAP12 INTERACTIONS 31 1.72e-02 2.47e-01 9.34e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 1.79e-02 2.46e-01 9.65e-02
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 11 1.61e-01 -2.44e-01 3.83e-01
RHO GTPASES ACTIVATE PAKS 22 4.75e-02 2.44e-01 1.84e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 74 2.99e-04 2.43e-01 3.40e-03
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 10 1.84e-01 -2.43e-01 4.22e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 21 5.54e-02 -2.42e-01 2.06e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.32e-01 2.41e-01 3.46e-01
GLUCOSE METABOLISM 64 9.31e-04 -2.39e-01 9.63e-03
GPVI MEDIATED ACTIVATION CASCADE 29 2.69e-02 2.38e-01 1.31e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 12 1.54e-01 2.37e-01 3.79e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 2.98e-02 -2.37e-01 1.38e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 15 1.12e-01 2.37e-01 3.13e-01
HS GAG DEGRADATION 19 7.49e-02 2.36e-01 2.47e-01
CONDENSATION OF PROPHASE CHROMOSOMES 12 1.59e-01 2.35e-01 3.80e-01
METABOLISM 1435 5.07e-49 -2.35e-01 1.52e-46
AQUAPORIN MEDIATED TRANSPORT 25 4.25e-02 -2.34e-01 1.74e-01
GLUTATHIONE CONJUGATION 32 2.33e-02 -2.32e-01 1.19e-01
SEMAPHORIN INTERACTIONS 50 4.68e-03 2.31e-01 3.60e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 22 6.06e-02 2.31e-01 2.19e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 1.36e-01 -2.30e-01 3.55e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 1.09e-02 -2.30e-01 6.76e-02
O LINKED GLYCOSYLATION 72 7.58e-04 2.30e-01 8.02e-03
RHOU GTPASE CYCLE 38 1.44e-02 2.29e-01 8.43e-02
AMINO ACIDS REGULATE MTORC1 46 7.32e-03 -2.29e-01 4.88e-02
FRS MEDIATED FGFR1 SIGNALING 13 1.56e-01 -2.27e-01 3.79e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 1.58e-01 2.26e-01 3.80e-01
SIGNALING BY NOTCH3 19 8.95e-02 -2.25e-01 2.69e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 12 1.80e-01 2.23e-01 4.15e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 10 2.25e-01 2.22e-01 4.75e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 6.64e-02 -2.21e-01 2.32e-01
FCGR ACTIVATION 11 2.05e-01 2.21e-01 4.53e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 1.86e-01 -2.21e-01 4.25e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 14 1.55e-01 -2.20e-01 3.79e-01
ACYL CHAIN REMODELLING OF PC 17 1.17e-01 -2.19e-01 3.22e-01
PYROPTOSIS 16 1.31e-01 2.18e-01 3.45e-01
TELOMERE C STRAND SYNTHESIS INITIATION 11 2.14e-01 2.16e-01 4.65e-01
ACYL CHAIN REMODELLING OF PG 10 2.41e-01 -2.14e-01 4.87e-01
SIGNALING BY MET 61 3.82e-03 2.14e-01 3.10e-02
PI 3K CASCADE FGFR1 12 2.00e-01 -2.14e-01 4.46e-01
GRB2 EVENTS IN ERBB2 SIGNALING 10 2.42e-01 2.14e-01 4.89e-01
ACYL CHAIN REMODELLING OF PE 15 1.53e-01 -2.13e-01 3.78e-01
SIGNALING BY TGFB FAMILY MEMBERS 105 1.65e-04 2.13e-01 2.15e-03
RAP1 SIGNALLING 15 1.57e-01 -2.11e-01 3.79e-01
REGULATION OF BACH1 ACTIVITY 10 2.50e-01 -2.10e-01 4.97e-01
SYNTHESIS OF PC 21 9.83e-02 -2.08e-01 2.87e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 11 2.32e-01 2.08e-01 4.82e-01
SEMA3A PAK DEPENDENT AXON REPULSION 14 1.78e-01 2.08e-01 4.13e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 30 4.93e-02 -2.07e-01 1.90e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 40 2.33e-02 -2.07e-01 1.19e-01
SHC1 EVENTS IN EGFR SIGNALING 11 2.34e-01 2.07e-01 4.84e-01
DEADENYLATION OF MRNA 22 9.32e-02 -2.07e-01 2.76e-01
SHC MEDIATED CASCADE FGFR4 11 2.36e-01 -2.07e-01 4.84e-01
SHC MEDIATED CASCADE FGFR3 11 2.36e-01 -2.07e-01 4.84e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 2.36e-01 2.06e-01 4.84e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 10 2.59e-01 -2.06e-01 5.07e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 24 8.44e-02 -2.04e-01 2.61e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 24 8.55e-02 -2.03e-01 2.62e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 11 2.46e-01 2.02e-01 4.94e-01
SHC MEDIATED CASCADE FGFR2 12 2.27e-01 -2.02e-01 4.75e-01
GAP JUNCTION DEGRADATION 11 2.47e-01 2.02e-01 4.95e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 33 4.72e-02 2.00e-01 1.84e-01
NEUROTRANSMITTER RELEASE CYCLE 30 5.85e-02 2.00e-01 2.15e-01
PROCESSING AND ACTIVATION OF SUMO 10 2.75e-01 2.00e-01 5.15e-01
SHC1 EVENTS IN ERBB4 SIGNALING 10 2.81e-01 1.97e-01 5.22e-01
RECYCLING PATHWAY OF L1 33 5.11e-02 1.96e-01 1.94e-01
RESOLUTION OF D LOOP STRUCTURES 29 6.82e-02 1.96e-01 2.33e-01
RAS PROCESSING 23 1.07e-01 -1.94e-01 3.02e-01
METHYLATION 13 2.26e-01 -1.94e-01 4.75e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 22 1.17e-01 -1.93e-01 3.22e-01
DRUG ADME 63 8.56e-03 -1.92e-01 5.58e-02
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 5.34e-02 -1.91e-01 2.00e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 23 1.14e-01 1.90e-01 3.16e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 28 8.22e-02 -1.90e-01 2.58e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 73 5.09e-03 1.90e-01 3.78e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 13 2.37e-01 1.89e-01 4.86e-01
PTEN REGULATION 95 1.45e-03 -1.89e-01 1.40e-02
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 14 2.21e-01 1.89e-01 4.72e-01
BILE ACID AND BILE SALT METABOLISM 28 8.43e-02 -1.89e-01 2.61e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 10 3.02e-01 -1.88e-01 5.46e-01
TIE2 SIGNALING 16 1.93e-01 -1.88e-01 4.39e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 2.65e-03 1.88e-01 2.25e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 15 2.08e-01 -1.88e-01 4.58e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 90 2.13e-03 -1.87e-01 1.92e-02
SPHINGOLIPID METABOLISM 72 6.30e-03 1.86e-01 4.39e-02
CELL CELL COMMUNICATION 70 7.08e-03 1.86e-01 4.76e-02
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 23 1.22e-01 1.86e-01 3.28e-01
BASIGIN INTERACTIONS 18 1.74e-01 1.85e-01 4.04e-01
STRIATED MUSCLE CONTRACTION 29 8.50e-02 1.85e-01 2.61e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 12 2.69e-01 1.84e-01 5.11e-01
RHOV GTPASE CYCLE 34 6.36e-02 1.84e-01 2.26e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 21 1.45e-01 1.84e-01 3.68e-01
MITF M DEPENDENT GENE EXPRESSION 15 2.21e-01 -1.83e-01 4.72e-01
NEGATIVE REGULATION OF FLT3 13 2.55e-01 1.83e-01 5.02e-01
HEME SIGNALING 12 2.75e-01 1.82e-01 5.15e-01
DEADENYLATION DEPENDENT MRNA DECAY 48 3.03e-02 -1.81e-01 1.40e-01
METABOLISM OF VITAMINS AND COFACTORS 157 9.56e-05 -1.81e-01 1.39e-03
EPHB MEDIATED FORWARD SIGNALING 35 6.44e-02 1.81e-01 2.27e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 12 2.79e-01 1.81e-01 5.22e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 20 1.62e-01 1.80e-01 3.86e-01
PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 10 3.25e-01 -1.80e-01 5.67e-01
GENERATION OF SECOND MESSENGER MOLECULES 12 2.81e-01 -1.80e-01 5.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 34 7.18e-02 1.78e-01 2.39e-01
RNA POLYMERASE II PROMOTER ESCAPE 44 4.16e-02 -1.78e-01 1.72e-01
FORMATION OF TC NER PRE INCISION COMPLEX 49 3.22e-02 -1.77e-01 1.46e-01
HEME DEGRADATION 10 3.37e-01 -1.75e-01 5.83e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 104 2.04e-03 -1.75e-01 1.87e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 3.38e-01 1.75e-01 5.83e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 7.84e-02 1.74e-01 2.52e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 3.17e-01 1.74e-01 5.60e-01
VLDLR INTERNALISATION AND DEGRADATION 15 2.43e-01 -1.74e-01 4.89e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 28 1.12e-01 1.74e-01 3.13e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 79 7.83e-03 1.73e-01 5.18e-02
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 3.00e-01 -1.73e-01 5.43e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 2.05e-01 -1.73e-01 4.53e-01
FORMATION OF WDR5 CONTAINING HISTONE MODIFYING COMPLEXES 36 7.41e-02 -1.72e-01 2.45e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 26 1.30e-01 -1.72e-01 3.43e-01
PECAM1 INTERACTIONS 11 3.25e-01 1.71e-01 5.67e-01
RHOB GTPASE CYCLE 65 1.69e-02 1.71e-01 9.24e-02
POLYMERASE SWITCHING 14 2.67e-01 1.71e-01 5.11e-01
AMINE LIGAND BINDING RECEPTORS 14 2.69e-01 -1.71e-01 5.11e-01
OXIDATIVE STRESS INDUCED SENESCENCE 37 7.36e-02 -1.70e-01 2.45e-01
INTERLEUKIN 6 FAMILY SIGNALING 16 2.40e-01 1.70e-01 4.87e-01
INTERLEUKIN 7 SIGNALING 12 3.09e-01 -1.70e-01 5.52e-01
DEGRADATION OF DVL 53 3.32e-02 -1.69e-01 1.50e-01
MRNA CAPPING 28 1.22e-01 -1.69e-01 3.28e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 12 3.11e-01 1.69e-01 5.55e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 2.92e-01 1.69e-01 5.36e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 3.12e-01 -1.69e-01 5.55e-01
CA2 PATHWAY 37 7.70e-02 -1.68e-01 2.49e-01
L1CAM INTERACTIONS 63 2.12e-02 1.68e-01 1.11e-01
GLYCOSPHINGOLIPID METABOLISM 42 6.02e-02 1.68e-01 2.19e-01
SIGNALING BY FGFR4 32 1.01e-01 -1.68e-01 2.90e-01
SIGNALING BY FGFR3 32 1.01e-01 -1.68e-01 2.90e-01
RND3 GTPASE CYCLE 36 8.38e-02 1.67e-01 2.61e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 11 3.39e-01 -1.66e-01 5.84e-01
ERBB2 REGULATES CELL MOTILITY 12 3.20e-01 1.66e-01 5.62e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 60 2.70e-02 -1.65e-01 1.31e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 110 2.80e-03 1.65e-01 2.36e-02
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 74 1.45e-02 -1.64e-01 8.43e-02
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 36 8.87e-02 -1.64e-01 2.68e-01
PROTEIN UBIQUITINATION 56 3.40e-02 -1.64e-01 1.53e-01
RHO GTPASE EFFECTORS 217 3.56e-05 1.63e-01 5.71e-04
GOLGI TO ER RETROGRADE TRANSPORT 116 2.43e-03 1.63e-01 2.13e-02
AZATHIOPRINE ADME 20 2.07e-01 -1.63e-01 4.57e-01
PKR MEDIATED SIGNALING 60 2.95e-02 1.63e-01 1.38e-01
REGULATION OF NF KAPPA B SIGNALING 16 2.64e-01 -1.61e-01 5.11e-01
ERK MAPK TARGETS 19 2.23e-01 -1.61e-01 4.74e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 2.81e-01 1.61e-01 5.22e-01
POTASSIUM CHANNELS 56 3.77e-02 -1.61e-01 1.59e-01
GENE SILENCING BY RNA 40 7.98e-02 -1.60e-01 2.54e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 12 3.38e-01 1.60e-01 5.83e-01
RAC3 GTPASE CYCLE 82 1.24e-02 1.60e-01 7.55e-02
PHASE II CONJUGATION OF COMPOUNDS 69 2.18e-02 -1.60e-01 1.13e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 16 2.70e-01 1.59e-01 5.12e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 12 3.41e-01 1.59e-01 5.84e-01
MAP2K AND MAPK ACTIVATION 36 9.93e-02 1.59e-01 2.88e-01
RAC1 GTPASE CYCLE 162 5.02e-04 1.59e-01 5.38e-03
PROTEIN HYDROXYLATION 16 2.73e-01 -1.58e-01 5.15e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 2.89e-01 -1.58e-01 5.33e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 17 2.59e-01 1.58e-01 5.07e-01
SIGNAL TRANSDUCTION BY L1 19 2.35e-01 1.57e-01 4.84e-01
UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 49 5.70e-02 -1.57e-01 2.10e-01
O LINKED GLYCOSYLATION OF MUCINS 30 1.37e-01 1.57e-01 3.56e-01
RAC2 GTPASE CYCLE 80 1.55e-02 1.57e-01 8.63e-02
CELL JUNCTION ORGANIZATION 59 3.77e-02 1.57e-01 1.59e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 42 8.00e-02 1.56e-01 2.54e-01
GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME 54 4.75e-02 -1.56e-01 1.84e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 17 2.66e-01 1.56e-01 5.11e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 49 5.92e-02 1.56e-01 2.17e-01
NUCLEAR EVENTS MEDIATED BY NFE2L2 53 5.01e-02 -1.56e-01 1.91e-01
CELLULAR RESPONSE TO HYPOXIA 65 3.05e-02 -1.55e-01 1.40e-01
MRNA SPLICING MINOR PATHWAY 47 6.57e-02 -1.55e-01 2.31e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 15 3.00e-01 1.54e-01 5.43e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 2.00e-01 -1.54e-01 4.46e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 2.00e-01 -1.54e-01 4.46e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 58 4.23e-02 -1.54e-01 1.74e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 24 1.92e-01 -1.54e-01 4.35e-01
CDC42 GTPASE CYCLE 90 1.20e-02 1.53e-01 7.39e-02
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 19 2.47e-01 1.53e-01 4.95e-01
DAP12 SIGNALING 21 2.25e-01 1.53e-01 4.75e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 16 2.93e-01 1.52e-01 5.36e-01
NRAGE SIGNALS DEATH THROUGH JNK 49 6.76e-02 1.51e-01 2.32e-01
RHO GTPASES ACTIVATE FORMINS 116 5.04e-03 1.51e-01 3.78e-02
KEAP1 NFE2L2 PATHWAY 73 2.65e-02 -1.50e-01 1.31e-01
SNRNP ASSEMBLY 47 7.57e-02 -1.50e-01 2.47e-01
ENDOGENOUS STEROLS 17 2.85e-01 -1.50e-01 5.27e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 23 2.15e-01 1.49e-01 4.65e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 31 1.51e-01 1.49e-01 3.76e-01
REGULATION OF KIT SIGNALING 12 3.72e-01 1.49e-01 6.12e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 1.34e-01 1.48e-01 3.52e-01
BIOLOGICAL OXIDATIONS 130 3.78e-03 -1.47e-01 3.09e-02
NEDDYLATION 207 2.75e-04 -1.47e-01 3.21e-03
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 4.23e-01 -1.46e-01 6.59e-01
NUCLEOTIDE SALVAGE 19 2.71e-01 1.46e-01 5.13e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 99 1.23e-02 1.46e-01 7.54e-02
SYNTHESIS OF PE 10 4.26e-01 -1.45e-01 6.59e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 2.39e-01 1.45e-01 4.87e-01
CD28 DEPENDENT VAV1 PATHWAY 11 4.08e-01 1.44e-01 6.46e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 12 3.89e-01 1.44e-01 6.21e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 54 6.89e-02 -1.43e-01 2.35e-01
INWARDLY RECTIFYING K CHANNELS 25 2.16e-01 -1.43e-01 4.66e-01
RNA POLYMERASE I TRANSCRIPTION 41 1.13e-01 -1.43e-01 3.15e-01
RHO GTPASES ACTIVATE IQGAPS 26 2.07e-01 1.43e-01 4.57e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 4.52e-02 -1.43e-01 1.82e-01
ION HOMEOSTASIS 45 9.86e-02 -1.42e-01 2.87e-01
METABOLISM OF FAT SOLUBLE VITAMINS 31 1.70e-01 1.42e-01 3.99e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 15 3.41e-01 1.42e-01 5.84e-01
REGULATION OF SIGNALING BY CBL 21 2.60e-01 1.42e-01 5.07e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 52 7.69e-02 1.42e-01 2.49e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 171 1.46e-03 1.41e-01 1.40e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 50 8.48e-02 -1.41e-01 2.61e-01
NERVOUS SYSTEM DEVELOPMENT 235 2.10e-04 1.41e-01 2.62e-03
NEUREXINS AND NEUROLIGINS 21 2.67e-01 1.40e-01 5.11e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 13 3.83e-01 1.40e-01 6.17e-01
DNA STRAND ELONGATION 24 2.38e-01 1.39e-01 4.86e-01
METABOLISM OF LIPIDS 463 3.52e-07 -1.39e-01 8.13e-06
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 51 8.76e-02 -1.38e-01 2.66e-01
IRAK1 RECRUITS IKK COMPLEX 14 3.71e-01 -1.38e-01 6.12e-01
EPH EPHRIN SIGNALING 57 7.16e-02 1.38e-01 2.39e-01
INITIAL TRIGGERING OF COMPLEMENT 13 3.89e-01 -1.38e-01 6.21e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 1.74e-01 -1.37e-01 4.04e-01
NONSENSE MEDIATED DECAY NMD INDEPENDENT OF THE EXON JUNCTION COMPLEX EJC 88 2.68e-02 -1.37e-01 1.31e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 75 4.11e-02 -1.37e-01 1.70e-01
GAB1 SIGNALOSOME 15 3.61e-01 1.36e-01 6.01e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 24 2.49e-01 -1.36e-01 4.96e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 3.82e-01 1.35e-01 6.16e-01
REGULATION OF CDH11 EXPRESSION AND FUNCTION 11 4.39e-01 1.35e-01 6.72e-01
EUKARYOTIC TRANSLATION INITIATION 112 1.38e-02 -1.35e-01 8.16e-02
CELLULAR RESPONSES TO STIMULI 420 2.36e-06 -1.35e-01 4.83e-05
RHO GTPASES ACTIVATE KTN1 10 4.61e-01 1.35e-01 6.92e-01
LGI ADAM INTERACTIONS 10 4.66e-01 -1.33e-01 6.95e-01
DNA DAMAGE RECOGNITION IN GG NER 38 1.59e-01 -1.32e-01 3.80e-01
NETRIN 1 SIGNALING 12 4.29e-01 1.32e-01 6.60e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 19 3.22e-01 1.31e-01 5.65e-01
ASPIRIN ADME 17 3.50e-01 -1.31e-01 5.90e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 66 6.71e-02 1.30e-01 2.32e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 254 3.61e-04 -1.30e-01 4.01e-03
METAL ION SLC TRANSPORTERS 17 3.53e-01 -1.30e-01 5.92e-01
FCERI MEDIATED NF KB ACTIVATION 70 6.07e-02 -1.30e-01 2.19e-01
CALCINEURIN ACTIVATES NFAT 10 4.78e-01 -1.30e-01 7.03e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 214 1.15e-03 1.29e-01 1.16e-02
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 31 2.14e-01 1.29e-01 4.65e-01
HDMS DEMETHYLATE HISTONES 21 3.07e-01 -1.29e-01 5.49e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 26 2.56e-01 1.29e-01 5.03e-01
METABOLISM OF FOLATE AND PTERINES 17 3.59e-01 -1.29e-01 5.98e-01
ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 20 3.20e-01 -1.29e-01 5.62e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 135 1.01e-02 -1.28e-01 6.38e-02
MISMATCH REPAIR MMR DIRECTED BY MSH2 MSH3 MUTSBETA 10 4.85e-01 -1.27e-01 7.10e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 16 3.78e-01 -1.27e-01 6.12e-01
VXPX CARGO TARGETING TO CILIUM 17 3.64e-01 1.27e-01 6.05e-01
SIGNALING BY FGFR2 51 1.22e-01 -1.25e-01 3.28e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 12 4.53e-01 1.25e-01 6.84e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 81 5.18e-02 -1.25e-01 1.95e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 45 1.48e-01 -1.25e-01 3.74e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 15 4.04e-01 1.24e-01 6.41e-01
MACROAUTOPHAGY 119 1.92e-02 -1.24e-01 1.03e-01
FORMATION OF THE CORNIFIED ENVELOPE 17 3.75e-01 1.24e-01 6.12e-01
KERATINIZATION 17 3.75e-01 1.24e-01 6.12e-01
EGFR DOWNREGULATION 28 2.56e-01 1.24e-01 5.03e-01
NONSENSE MEDIATED DECAY NMD 107 2.71e-02 -1.24e-01 1.31e-01
REGULATION OF TBK1 IKK IKBKE MEDIATED ACTIVATION OF IRF3 IRF7 14 4.24e-01 1.23e-01 6.59e-01
HEMOSTASIS 424 1.49e-05 1.23e-01 2.63e-04
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 32 2.30e-01 -1.23e-01 4.78e-01
STABILIZATION OF P53 52 1.28e-01 -1.22e-01 3.39e-01
HDR THROUGH MMEJ ALT NHEJ 12 4.65e-01 -1.22e-01 6.95e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 54 1.22e-01 -1.22e-01 3.28e-01
CARDIAC CONDUCTION 76 6.73e-02 -1.21e-01 2.32e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 45 1.59e-01 1.21e-01 3.81e-01
PLASMA LIPOPROTEIN CLEARANCE 28 2.67e-01 -1.21e-01 5.11e-01
SIGNALING BY PTK6 44 1.64e-01 1.21e-01 3.87e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK IKBKE 17 3.87e-01 1.21e-01 6.20e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 28 2.67e-01 -1.21e-01 5.11e-01
SENSORY PERCEPTION 56 1.18e-01 1.21e-01 3.23e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 29 2.60e-01 -1.21e-01 5.07e-01
LAGGING STRAND SYNTHESIS 20 3.53e-01 1.20e-01 5.92e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 11 4.92e-01 -1.20e-01 7.11e-01
VISUAL PHOTOTRANSDUCTION 51 1.41e-01 1.19e-01 3.65e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 10 5.15e-01 1.19e-01 7.32e-01
COPII MEDIATED VESICLE TRANSPORT 66 9.70e-02 -1.18e-01 2.84e-01
NICOTINAMIDE SALVAGING 15 4.28e-01 1.18e-01 6.60e-01
IRON UPTAKE AND TRANSPORT 46 1.66e-01 -1.18e-01 3.91e-01
RHOC GTPASE CYCLE 65 9.98e-02 1.18e-01 2.89e-01
PLASMA LIPOPROTEIN REMODELING 19 3.74e-01 -1.18e-01 6.12e-01
RHOA GTPASE CYCLE 132 1.97e-02 1.18e-01 1.04e-01
DEGRADATION OF AXIN 52 1.45e-01 -1.17e-01 3.68e-01
HS GAG BIOSYNTHESIS 21 3.54e-01 1.17e-01 5.92e-01
GLYCOSPHINGOLIPID CATABOLISM 28 2.85e-01 1.17e-01 5.27e-01
MET ACTIVATES RAP1 AND RAC1 11 5.06e-01 1.16e-01 7.25e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 4.44e-02 1.15e-01 1.81e-01
DUAL INCISION IN GG NER 41 2.02e-01 -1.15e-01 4.48e-01
FOXO MEDIATED TRANSCRIPTION 20 3.73e-01 -1.15e-01 6.12e-01
INTERFERON GAMMA SIGNALING 18 3.99e-01 -1.15e-01 6.35e-01
TELOMERE EXTENSION BY TELOMERASE 17 4.13e-01 -1.15e-01 6.48e-01
MRNA SPLICING 190 6.51e-03 -1.15e-01 4.47e-02
CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 69 1.03e-01 -1.14e-01 2.95e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.53e-01 -1.13e-01 3.79e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 53 1.55e-01 1.13e-01 3.79e-01
SMOOTH MUSCLE CONTRACTION 29 2.93e-01 1.13e-01 5.36e-01
HEDGEHOG LIGAND BIOGENESIS 56 1.44e-01 -1.13e-01 3.68e-01
PHOSPHOLIPID METABOLISM 157 1.52e-02 -1.12e-01 8.63e-02
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 11 5.20e-01 1.12e-01 7.35e-01
DOWNSTREAM TCR SIGNALING 78 9.03e-02 -1.11e-01 2.70e-01
METABOLISM OF NUCLEOTIDES 77 9.34e-02 -1.11e-01 2.76e-01
INTERLEUKIN 17 SIGNALING 57 1.50e-01 -1.10e-01 3.75e-01
RAB REGULATION OF TRAFFICKING 109 4.72e-02 -1.10e-01 1.84e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 56 1.55e-01 -1.10e-01 3.79e-01
LYSOSOME VESICLE BIOGENESIS 30 3.00e-01 1.09e-01 5.43e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 359 4.22e-04 1.09e-01 4.57e-03
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 16 4.52e-01 -1.09e-01 6.84e-01
RHO GTPASE CYCLE 390 2.52e-04 1.08e-01 3.02e-03
CD28 CO STIMULATION 31 2.97e-01 1.08e-01 5.42e-01
G PROTEIN ACTIVATION 15 4.69e-01 -1.08e-01 6.98e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 130 3.62e-02 1.07e-01 1.57e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 73 1.16e-01 -1.07e-01 3.20e-01
METABOLISM OF PROTEINS 1445 2.98e-11 -1.06e-01 1.34e-09
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 12 5.25e-01 -1.06e-01 7.38e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 86 8.99e-02 1.06e-01 2.70e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 30 3.16e-01 1.06e-01 5.59e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 92 7.99e-02 1.06e-01 2.54e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 61 1.55e-01 -1.05e-01 3.79e-01
SIGNALLING TO RAS 12 5.29e-01 -1.05e-01 7.41e-01
UCH PROTEINASES 77 1.12e-01 -1.05e-01 3.13e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 30 3.23e-01 -1.04e-01 5.65e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND 46 2.21e-01 1.04e-01 4.72e-01
REGULATED PROTEOLYSIS OF P75NTR 10 5.69e-01 1.04e-01 7.68e-01
ACYL CHAIN REMODELLING OF PS 14 5.02e-01 -1.04e-01 7.22e-01
MITOTIC PROPHASE 67 1.44e-01 -1.03e-01 3.68e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 73 1.28e-01 -1.03e-01 3.39e-01
RHOJ GTPASE CYCLE 15 4.90e-01 1.03e-01 7.11e-01
ION TRANSPORT BY P TYPE ATPASES 41 2.54e-01 1.03e-01 5.02e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 83 1.07e-01 1.02e-01 3.02e-01
G1 S DNA DAMAGE CHECKPOINTS 61 1.68e-01 -1.02e-01 3.94e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 18 4.53e-01 -1.02e-01 6.84e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 16 4.82e-01 -1.02e-01 7.06e-01
SELECTIVE AUTOPHAGY 63 1.64e-01 -1.02e-01 3.87e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 564 4.32e-05 1.01e-01 6.73e-04
AURKA ACTIVATION BY TPX2 68 1.50e-01 1.01e-01 3.75e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 68 1.50e-01 -1.01e-01 3.75e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 19 4.46e-01 1.01e-01 6.80e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 2.89e-01 -1.01e-01 5.33e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 44 2.48e-01 -1.01e-01 4.95e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 84 1.11e-01 -1.01e-01 3.13e-01
DEVELOPMENTAL BIOLOGY 316 2.23e-03 1.00e-01 1.99e-02
PLATELET SENSITIZATION BY LDL 16 4.88e-01 -1.00e-01 7.11e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 29 3.51e-01 -1.00e-01 5.91e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 56 1.98e-01 -9.96e-02 4.45e-01
NUCLEOTIDE EXCISION REPAIR 105 7.90e-02 -9.93e-02 2.53e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 20 4.42e-01 9.92e-02 6.76e-01
OVARIAN TUMOR DOMAIN PROTEASES 31 3.40e-01 9.90e-02 5.84e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 59 1.90e-01 -9.86e-02 4.34e-01
COHESIN LOADING ONTO CHROMATIN 10 5.90e-01 -9.84e-02 7.87e-01
MITOTIC PROMETAPHASE 171 2.68e-02 9.83e-02 1.31e-01
PARACETAMOL ADME 20 4.47e-01 -9.82e-02 6.81e-01
PENTOSE PHOSPHATE PATHWAY 14 5.26e-01 -9.79e-02 7.38e-01
METABOLISM OF POLYAMINES 54 2.14e-01 -9.78e-02 4.65e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 20 4.49e-01 -9.77e-02 6.83e-01
PI METABOLISM 72 1.52e-01 9.77e-02 3.78e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 71 1.56e-01 -9.73e-02 3.79e-01
G2 M DNA DAMAGE CHECKPOINT 52 2.27e-01 9.69e-02 4.75e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 32 3.49e-01 -9.58e-02 5.90e-01
COMPLEMENT CASCADE 26 4.01e-01 -9.53e-02 6.37e-01
RMTS METHYLATE HISTONE ARGININES 25 4.10e-01 -9.52e-02 6.46e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 14 5.38e-01 9.50e-02 7.50e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 13 5.54e-01 9.48e-02 7.58e-01
AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES 79 1.48e-01 9.42e-02 3.74e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 62 2.00e-01 -9.42e-02 4.46e-01
SIGNALING BY HEDGEHOG 125 7.02e-02 9.39e-02 2.37e-01
G PROTEIN MEDIATED EVENTS 36 3.30e-01 9.39e-02 5.73e-01
FC EPSILON RECEPTOR FCERI SIGNALING 110 9.08e-02 -9.34e-02 2.71e-01
CHROMOSOME MAINTENANCE 66 1.90e-01 9.32e-02 4.34e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 34 3.47e-01 9.32e-02 5.90e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 56 2.29e-01 9.31e-02 4.77e-01
CTLA4 INHIBITORY SIGNALING 20 4.72e-01 -9.29e-02 7.00e-01
REGULATION OF TP53 DEGRADATION 34 3.49e-01 -9.29e-02 5.90e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 14 5.48e-01 -9.27e-02 7.54e-01
METABOLISM OF RNA 559 2.07e-04 -9.23e-02 2.62e-03
BETA CATENIN INDEPENDENT WNT SIGNALING 112 9.41e-02 -9.17e-02 2.77e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 5.68e-01 -9.16e-02 7.68e-01
TRANSCRIPTIONAL REGULATION BY TP53 274 9.32e-03 -9.15e-02 6.04e-02
RHOD GTPASE CYCLE 49 2.71e-01 9.09e-02 5.13e-01
RHOF GTPASE CYCLE 39 3.28e-01 9.05e-02 5.71e-01
ERKS ARE INACTIVATED 13 5.73e-01 -9.04e-02 7.72e-01
RA BIOSYNTHESIS PATHWAY 15 5.46e-01 -9.00e-02 7.54e-01
GPER1 SIGNALING 22 4.66e-01 8.98e-02 6.95e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 169 4.47e-02 8.96e-02 1.81e-01
RHO GTPASES ACTIVATE PKNS 21 4.78e-01 8.95e-02 7.03e-01
RND1 GTPASE CYCLE 38 3.43e-01 8.89e-02 5.86e-01
TRAFFICKING OF AMPA RECEPTORS 22 4.75e-01 8.81e-02 7.03e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 4.96e-01 8.79e-02 7.17e-01
SIGNALING BY WNT 201 3.20e-02 -8.79e-02 1.46e-01
DEATH RECEPTOR SIGNALING 131 8.37e-02 8.76e-02 2.61e-01
RHOBTB GTPASE CYCLE 34 3.78e-01 8.75e-02 6.12e-01
REGULATION OF RAS BY GAPS 63 2.35e-01 -8.65e-02 4.84e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 12 6.04e-01 -8.65e-02 7.96e-01
CELLULAR RESPONSE TO HEAT STRESS 81 1.80e-01 -8.63e-02 4.15e-01
RAF ACTIVATION 34 3.86e-01 -8.59e-02 6.19e-01
G0 AND EARLY G1 16 5.53e-01 -8.57e-02 7.58e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 68 2.23e-01 -8.55e-02 4.74e-01
SIGNALING BY NUCLEAR RECEPTORS 144 7.76e-02 -8.53e-02 2.50e-01
INTERFERON ALPHA BETA SIGNALING 19 5.21e-01 8.51e-02 7.35e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 10 6.42e-01 8.49e-02 8.25e-01
NEGATIVE REGULATION OF MAPK PATHWAY 41 3.49e-01 -8.45e-02 5.90e-01
MET RECEPTOR RECYCLING 10 6.46e-01 8.38e-02 8.26e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 11 6.32e-01 -8.35e-02 8.19e-01
TRANSLESION SYNTHESIS BY POLH 18 5.40e-01 -8.34e-02 7.51e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 19 5.31e-01 -8.31e-02 7.43e-01
TBC RABGAPS 33 4.09e-01 -8.30e-02 6.46e-01
C TYPE LECTIN RECEPTORS CLRS 104 1.44e-01 -8.29e-02 3.68e-01
NUCLEAR ENVELOPE NE REASSEMBLY 61 2.64e-01 8.27e-02 5.11e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 12 6.20e-01 -8.26e-02 8.10e-01
APOPTOTIC EXECUTION PHASE 42 3.55e-01 8.26e-02 5.92e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 6.21e-01 8.24e-02 8.10e-01
CHROMATIN MODIFYING ENZYMES 136 1.06e-01 -8.04e-02 3.01e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 5.24e-01 8.02e-02 7.38e-01
CLEC7A DECTIN 1 SIGNALING 88 1.94e-01 -8.01e-02 4.39e-01
PI3K EVENTS IN ERBB2 SIGNALING 13 6.20e-01 7.95e-02 8.10e-01
TRANS GOLGI NETWORK VESICLE BUDDING 66 2.67e-01 7.90e-02 5.11e-01
SPRY REGULATION OF FGF SIGNALING 16 5.86e-01 -7.87e-02 7.85e-01
PEXOPHAGY 10 6.67e-01 -7.87e-02 8.35e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 80 2.25e-01 7.85e-02 4.75e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 86 2.10e-01 7.82e-02 4.61e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 273 2.76e-02 -7.77e-02 1.32e-01
ACTIVATION OF NF KAPPAB IN B CELLS 59 3.03e-01 -7.75e-02 5.46e-01
MITF M REGULATED MELANOCYTE DEVELOPMENT 29 4.71e-01 -7.74e-02 6.99e-01
DUAL INCISION IN TC NER 61 2.99e-01 -7.70e-02 5.43e-01
NUCLEAR ENVELOPE BREAKDOWN 45 3.76e-01 -7.63e-02 6.12e-01
SHC MEDIATED CASCADE FGFR1 11 6.61e-01 -7.63e-02 8.35e-01
G ALPHA 12 13 SIGNALLING EVENTS 69 2.74e-01 7.62e-02 5.15e-01
CELLULAR SENESCENCE 91 2.12e-01 -7.58e-02 4.62e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 81 2.40e-01 -7.56e-02 4.87e-01
SIGNALING BY CSF3 G CSF 19 5.69e-01 -7.55e-02 7.68e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 39 4.15e-01 7.55e-02 6.50e-01
MHC CLASS II ANTIGEN PRESENTATION 98 1.97e-01 7.55e-02 4.45e-01
INTRA GOLGI TRAFFIC 33 4.59e-01 -7.45e-02 6.89e-01
FCERI MEDIATED MAPK ACTIVATION 26 5.12e-01 -7.43e-02 7.30e-01
METALLOPROTEASE DUBS 17 5.97e-01 7.41e-02 7.90e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 13 6.44e-01 -7.39e-02 8.25e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 51 3.65e-01 -7.34e-02 6.05e-01
INOSITOL PHOSPHATE METABOLISM 42 4.12e-01 7.32e-02 6.48e-01
MITOTIC SPINDLE CHECKPOINT 96 2.16e-01 7.31e-02 4.66e-01
RHOQ GTPASE CYCLE 56 3.45e-01 7.29e-02 5.88e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 6.76e-01 -7.27e-02 8.43e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 5.48e-01 7.24e-02 7.54e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 21 5.67e-01 -7.21e-02 7.68e-01
PROTEIN METHYLATION 17 6.08e-01 -7.20e-02 7.98e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 81 2.65e-01 -7.18e-02 5.11e-01
INSULIN RECEPTOR SIGNALLING CASCADE 33 4.79e-01 -7.13e-02 7.03e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 4.55e-01 7.10e-02 6.85e-01
TCR SIGNALING 90 2.53e-01 -6.97e-02 5.02e-01
REGULATED NECROSIS 45 4.20e-01 6.95e-02 6.56e-01
ACTIVATION OF BH3 ONLY PROTEINS 17 6.20e-01 6.94e-02 8.10e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 224 7.51e-02 -6.92e-02 2.47e-01
ACTIVATION OF APC C AND APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 72 3.13e-01 -6.88e-02 5.55e-01
TELOMERE MAINTENANCE 47 4.15e-01 6.87e-02 6.50e-01
SIGNALING BY ERYTHROPOIETIN 16 6.35e-01 6.85e-02 8.21e-01
RHOBTB1 GTPASE CYCLE 22 5.81e-01 6.80e-02 7.81e-01
MITOTIC G2 G2 M PHASES 171 1.29e-01 6.75e-02 3.40e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 5.36e-01 -6.65e-02 7.47e-01
INTERACTION BETWEEN L1 AND ANKYRINS 10 7.17e-01 6.62e-02 8.67e-01
IRS MEDIATED SIGNALLING 28 5.47e-01 -6.59e-02 7.54e-01
MYOGENESIS 17 6.40e-01 6.54e-02 8.25e-01
GENE EXPRESSION TRANSCRIPTION 921 8.93e-04 -6.52e-02 9.35e-03
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 18 6.33e-01 -6.50e-02 8.20e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 27 5.62e-01 -6.45e-02 7.63e-01
LDL CLEARANCE 15 6.66e-01 6.45e-02 8.35e-01
MYD88 MAL TIRAP CASCADE INITIATED ON PLASMA MEMBRANE 81 3.19e-01 -6.41e-02 5.62e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 36 5.08e-01 6.37e-02 7.27e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 6.60e-01 -6.35e-02 8.35e-01
TRANSPORT OF SMALL MOLECULES 500 1.58e-02 -6.34e-02 8.71e-02
CELL CYCLE 508 1.52e-02 6.32e-02 8.63e-02
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 24 5.93e-01 -6.31e-02 7.88e-01
DNA DOUBLE STRAND BREAK RESPONSE 41 4.86e-01 -6.29e-02 7.10e-01
N GLYCAN ANTENNAE ELONGATION 13 6.95e-01 6.28e-02 8.51e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 20 6.27e-01 6.28e-02 8.14e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 79 3.35e-01 6.28e-02 5.81e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 14 6.86e-01 6.25e-02 8.44e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 6.66e-01 -6.24e-02 8.35e-01
SIGNALING BY THE B CELL RECEPTOR BCR 94 2.98e-01 -6.22e-02 5.42e-01
HOMOLOGY DIRECTED REPAIR 93 3.05e-01 6.17e-02 5.46e-01
FATTY ACYL COA BIOSYNTHESIS 26 5.87e-01 -6.16e-02 7.85e-01
CHAPERONIN MEDIATED PROTEIN FOLDING 31 5.55e-01 -6.12e-02 7.58e-01
SURFACTANT METABOLISM 14 6.92e-01 6.12e-02 8.48e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 25 5.96e-01 -6.12e-02 7.90e-01
PEPTIDE LIGAND BINDING RECEPTORS 57 4.26e-01 -6.10e-02 6.59e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 7.26e-01 -6.10e-02 8.74e-01
CELL CYCLE CHECKPOINTS 226 1.19e-01 6.03e-02 3.24e-01
PCP CE PATHWAY 82 3.46e-01 -6.03e-02 5.88e-01
INTERLEUKIN 20 FAMILY SIGNALING 11 7.36e-01 -5.87e-02 8.76e-01
INNATE IMMUNE SYSTEM 712 8.49e-03 5.83e-02 5.57e-02
EXTENSION OF TELOMERES 43 5.09e-01 5.82e-02 7.27e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 5.00e-01 -5.82e-02 7.21e-01
NEUTROPHIL DEGRANULATION 386 5.17e-02 5.79e-02 1.95e-01
PROGRAMMED CELL DEATH 117 2.83e-01 5.75e-02 5.26e-01
TRP CHANNELS 15 7.00e-01 5.75e-02 8.56e-01
DNA DAMAGE BYPASS 46 5.02e-01 5.72e-02 7.22e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 3.79e-01 -5.66e-02 6.12e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 31 5.91e-01 5.57e-02 7.87e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 3.76e-01 -5.53e-02 6.12e-01
STIMULI SENSING CHANNELS 62 4.52e-01 -5.53e-02 6.84e-01
SIGNALING BY NOTCH 38 5.62e-01 -5.44e-02 7.63e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 16 7.08e-01 5.41e-02 8.60e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 29 6.15e-01 5.39e-02 8.07e-01
POST NMDA RECEPTOR ACTIVATION EVENTS 14 7.28e-01 5.36e-02 8.75e-01
FGFR2 ALTERNATIVE SPLICING 17 7.02e-01 -5.36e-02 8.57e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 20 6.84e-01 5.25e-02 8.44e-01
GLUTAMATE AND GLUTAMINE METABOLISM 10 7.76e-01 -5.19e-02 8.99e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 30 6.24e-01 5.17e-02 8.13e-01
SIGNALING BY VEGF 98 3.77e-01 5.17e-02 6.12e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 21 6.82e-01 5.16e-02 8.44e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 60 4.92e-01 5.14e-02 7.11e-01
ESTROGEN DEPENDENT GENE EXPRESSION 43 5.61e-01 -5.13e-02 7.63e-01
GENERIC TRANSCRIPTION PATHWAY 690 2.26e-02 -5.13e-02 1.16e-01
CELL CELL JUNCTION ORGANIZATION 37 5.90e-01 5.13e-02 7.87e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 28 6.40e-01 5.11e-02 8.25e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 314 1.23e-01 -5.07e-02 3.29e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 86 4.18e-01 5.06e-02 6.53e-01
NUCLEOTIDE CATABOLISM 28 6.44e-01 -5.05e-02 8.25e-01
SIGNALING BY GPCR 323 1.22e-01 5.02e-02 3.28e-01
RNA POLYMERASE II PRE TRANSCRIPTION EVENTS 72 4.62e-01 -5.01e-02 6.92e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 27 6.54e-01 -4.98e-02 8.34e-01
HSF1 DEPENDENT TRANSACTIVATION 23 6.80e-01 -4.97e-02 8.44e-01
RND2 GTPASE CYCLE 37 6.06e-01 4.90e-02 7.97e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 89 4.26e-01 4.88e-02 6.59e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 30 6.44e-01 4.87e-02 8.25e-01
METABOLISM OF STEROIDS 80 4.55e-01 -4.84e-02 6.85e-01
IMMUNE SYSTEM 1247 4.63e-03 4.83e-02 3.60e-02
METABOLISM OF CARBOHYDRATES 219 2.19e-01 4.83e-02 4.70e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 90 4.29e-01 4.83e-02 6.60e-01
G PROTEIN BETA GAMMA SIGNALLING 27 6.65e-01 -4.82e-02 8.35e-01
REGULATION OF ENDOGENOUS RETROELEMENTS 28 6.62e-01 4.77e-02 8.35e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 42 5.94e-01 4.76e-02 7.88e-01
BETA CATENIN PHOSPHORYLATION CASCADE 17 7.34e-01 -4.76e-02 8.75e-01
APOPTOSIS 89 4.39e-01 4.75e-02 6.72e-01
INACTIVATION OF CSF3 G CSF SIGNALING 15 7.51e-01 -4.73e-02 8.87e-01
G2 M CHECKPOINTS 121 3.73e-01 4.70e-02 6.12e-01
MITOTIC TELOPHASE CYTOKINESIS 13 7.71e-01 4.66e-02 8.99e-01
INTERLEUKIN 2 FAMILY SIGNALING 26 6.81e-01 4.65e-02 8.44e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 26 6.82e-01 4.64e-02 8.44e-01
TNFR1 INDUCED NF KAPPA B SIGNALING PATHWAY 32 6.50e-01 4.64e-02 8.30e-01
HEDGEHOG ON STATE 75 4.88e-01 4.63e-02 7.11e-01
SIGNALING BY EGFR 43 6.00e-01 4.62e-02 7.93e-01
SIGNALLING TO ERKS 25 6.91e-01 -4.59e-02 8.48e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 11 7.93e-01 -4.58e-02 9.07e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 360 1.39e-01 4.56e-02 3.60e-01
NOD1 2 SIGNALING PATHWAY 30 6.66e-01 -4.55e-02 8.35e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 23 7.06e-01 4.55e-02 8.60e-01
RHOG GTPASE CYCLE 67 5.21e-01 4.54e-02 7.35e-01
OTHER SEMAPHORIN INTERACTIONS 14 7.70e-01 -4.52e-02 8.99e-01
INTERFERON SIGNALING 115 4.05e-01 4.50e-02 6.42e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 72 5.13e-01 -4.46e-02 7.30e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 51 5.82e-01 4.46e-02 7.81e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 60 5.52e-01 -4.45e-02 7.58e-01
BASE EXCISION REPAIR AP SITE FORMATION 15 7.66e-01 4.44e-02 8.96e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 17 7.52e-01 4.43e-02 8.87e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 19 7.39e-01 -4.41e-02 8.78e-01
DOWNREGULATION OF ERBB2 SIGNALING 24 7.09e-01 4.40e-02 8.60e-01
ORC1 REMOVAL FROM CHROMATIN 65 5.42e-01 -4.37e-02 7.52e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 65 5.47e-01 4.32e-02 7.54e-01
RET SIGNALING 34 6.63e-01 -4.32e-02 8.35e-01
TNF SIGNALING 55 5.81e-01 -4.31e-02 7.81e-01
PEPTIDE HORMONE METABOLISM 34 6.70e-01 4.23e-02 8.37e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 89 4.91e-01 4.23e-02 7.11e-01
NEURONAL SYSTEM 202 3.04e-01 4.20e-02 5.46e-01
NICOTINATE METABOLISM 25 7.18e-01 4.18e-02 8.67e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 6.02e-01 -4.14e-02 7.95e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 18 7.62e-01 4.13e-02 8.95e-01
ONCOGENE INDUCED SENESCENCE 16 7.77e-01 -4.10e-02 8.99e-01
ENOS ACTIVATION 12 8.06e-01 -4.10e-02 9.15e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 8.15e-01 4.08e-02 9.22e-01
SIGNALING BY ERBB2 40 6.58e-01 4.05e-02 8.35e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 4.79e-01 -4.04e-02 7.03e-01
PHOSPHORYLATION OF THE APC C 19 7.63e-01 3.99e-02 8.95e-01
METABOLISM OF STEROID HORMONES 15 7.90e-01 -3.96e-02 9.07e-01
SIGNALING BY NOTCH1 18 7.72e-01 3.95e-02 8.99e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 25 7.33e-01 -3.95e-02 8.75e-01
TNFR2 NON CANONICAL NF KB PATHWAY 75 5.56e-01 3.94e-02 7.58e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 168 3.86e-01 3.88e-02 6.19e-01
RESOLUTION OF ABASIC SITES AP SITES 37 6.85e-01 3.86e-02 8.44e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 14 8.05e-01 3.81e-02 9.15e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 28 7.30e-01 -3.76e-02 8.75e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 120 4.78e-01 -3.76e-02 7.03e-01
PURINE SALVAGE 11 8.29e-01 -3.75e-02 9.28e-01
COSTIMULATION BY THE CD28 FAMILY 52 6.41e-01 -3.74e-02 8.25e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 23 7.60e-01 -3.69e-02 8.95e-01
SIGNALING BY SCF KIT 33 7.18e-01 -3.63e-02 8.67e-01
HEDGEHOG OFF STATE 100 5.32e-01 3.62e-02 7.44e-01
RNA POLYMERASE III TRANSCRIPTION 34 7.23e-01 -3.52e-02 8.72e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 7.81e-01 3.50e-02 9.01e-01
CLATHRIN MEDIATED ENDOCYTOSIS 120 5.18e-01 3.42e-02 7.34e-01
NUCLEAR SIGNALING BY ERBB4 11 8.44e-01 3.42e-02 9.36e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 7.82e-01 -3.41e-02 9.01e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 14 8.26e-01 3.40e-02 9.28e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 27 7.60e-01 3.39e-02 8.95e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 24 7.74e-01 3.38e-02 8.99e-01
FANCONI ANEMIA PATHWAY 33 7.38e-01 -3.37e-02 8.77e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 41 7.09e-01 -3.37e-02 8.60e-01
UNFOLDED PROTEIN RESPONSE UPR 10 8.55e-01 3.33e-02 9.39e-01
SIGNALING BY INSULIN RECEPTOR 56 6.67e-01 -3.33e-02 8.35e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 7.80e-01 3.30e-02 9.01e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 8.58e-01 3.26e-02 9.40e-01
MAPK FAMILY SIGNALING CASCADES 258 3.71e-01 3.24e-02 6.12e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 8.30e-01 3.20e-02 9.28e-01
RAB GERANYLGERANYLATION 52 6.91e-01 -3.19e-02 8.48e-01
GLUCAGON TYPE LIGAND RECEPTORS 17 8.21e-01 3.18e-02 9.27e-01
UB SPECIFIC PROCESSING PROTEASES 151 5.03e-01 -3.16e-02 7.22e-01
SIGNAL AMPLIFICATION 26 7.81e-01 3.14e-02 9.01e-01
G ALPHA S SIGNALLING EVENTS 62 6.73e-01 3.10e-02 8.40e-01
CYCLIN D ASSOCIATED EVENTS IN G1 41 7.32e-01 3.10e-02 8.75e-01
REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 32 7.63e-01 3.09e-02 8.95e-01
SYNAPTIC ADHESION LIKE MOLECULES 15 8.37e-01 3.08e-02 9.33e-01
ANTIMICROBIAL PEPTIDES 11 8.60e-01 3.07e-02 9.41e-01
SIALIC ACID METABOLISM 25 7.94e-01 3.02e-02 9.07e-01
MAPK6 MAPK4 SIGNALING 70 6.63e-01 -3.02e-02 8.35e-01
TOLL LIKE RECEPTOR CASCADES 138 5.42e-01 3.01e-02 7.52e-01
PLATELET CALCIUM HOMEOSTASIS 22 8.10e-01 2.96e-02 9.18e-01
ISG15 ANTIVIRAL MECHANISM 27 7.91e-01 -2.95e-02 9.07e-01
GAMMA CARBOXYLATION HYPUSINYLATION HYDROXYLATION AND ARYLSULFATASE ACTIVATION 45 7.33e-01 -2.94e-02 8.75e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 8.74e-01 2.91e-02 9.50e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 20 8.25e-01 -2.85e-02 9.28e-01
MISMATCH REPAIR 14 8.55e-01 -2.83e-02 9.39e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 14 8.56e-01 2.81e-02 9.39e-01
EPHRIN SIGNALING 18 8.38e-01 -2.79e-02 9.33e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 22 8.22e-01 -2.77e-02 9.27e-01
THE PHOTOTRANSDUCTION CASCADE 17 8.43e-01 -2.77e-02 9.36e-01
PRC2 METHYLATES HISTONES AND DNA 15 8.54e-01 -2.75e-02 9.39e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 37 7.73e-01 2.74e-02 8.99e-01
MITOTIC METAPHASE AND ANAPHASE 202 5.13e-01 2.67e-02 7.30e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 33 7.92e-01 2.66e-02 9.07e-01
ESTABLISHMENT OF SISTER CHROMATID COHESION 10 8.85e-01 -2.65e-02 9.57e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 14 8.66e-01 2.61e-02 9.46e-01
INTERLEUKIN 1 SIGNALING 96 6.61e-01 -2.60e-02 8.35e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 15 8.67e-01 2.50e-02 9.46e-01
OPIOID SIGNALLING 59 7.41e-01 -2.49e-02 8.79e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 14 8.72e-01 2.49e-02 9.49e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 26 8.27e-01 2.48e-02 9.28e-01
DEPOLYMERIZATION OF THE NUCLEAR LAMINA 11 8.87e-01 2.47e-02 9.58e-01
CA DEPENDENT EVENTS 25 8.32e-01 2.45e-02 9.29e-01
DNA REPLICATION PRE INITIATION 97 6.82e-01 -2.41e-02 8.44e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 49 7.74e-01 2.37e-02 8.99e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 23 8.46e-01 -2.34e-02 9.37e-01
BASE EXCISION REPAIR 42 7.95e-01 2.32e-02 9.07e-01
SIGNALING BY INTERLEUKINS 222 5.54e-01 2.31e-02 7.58e-01
SIGNALING BY ROBO RECEPTORS 20 8.58e-01 -2.31e-02 9.40e-01
ADHERENS JUNCTIONS INTERACTIONS 29 8.40e-01 2.16e-02 9.35e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 126 6.78e-01 2.14e-02 8.44e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 9.03e-01 2.13e-02 9.65e-01
SIGNALING BY ACTIVIN 14 8.91e-01 -2.12e-02 9.59e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 40 8.20e-01 -2.08e-02 9.27e-01
VESICLE MEDIATED TRANSPORT 522 4.35e-01 2.01e-02 6.67e-01
CD209 DC SIGN SIGNALING 16 8.93e-01 -1.95e-02 9.59e-01
PKMTS METHYLATE HISTONE LYSINES 36 8.44e-01 -1.90e-02 9.36e-01
RETROGRADE NEUROTROPHIN SIGNALLING 10 9.17e-01 1.90e-02 9.70e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 7.88e-01 1.89e-02 9.06e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 13 9.07e-01 1.88e-02 9.65e-01
SUMOYLATION 144 7.03e-01 1.84e-02 8.58e-01
SIGNALING BY FGFR 62 8.04e-01 -1.83e-02 9.14e-01
TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION 36 8.52e-01 1.80e-02 9.39e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 38 8.49e-01 1.78e-02 9.39e-01
ATTENUATION PHASE 13 9.12e-01 1.78e-02 9.67e-01
DNA REPAIR 257 6.26e-01 -1.77e-02 8.14e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 11 9.19e-01 1.77e-02 9.71e-01
PURINE CATABOLISM 16 9.03e-01 1.76e-02 9.65e-01
TRANSCRIPTIONAL AND POST TRANSLATIONAL REGULATION OF MITF M EXPRESSION AND ACTIVITY 16 9.07e-01 -1.69e-02 9.65e-01
DOWNSTREAM SIGNAL TRANSDUCTION 26 8.82e-01 1.69e-02 9.56e-01
INTEGRATION OF ENERGY METABOLISM 59 8.24e-01 1.67e-02 9.28e-01
SEPARATION OF SISTER CHROMATIDS 165 7.25e-01 1.59e-02 8.74e-01
FCERI MEDIATED CA 2 MOBILIZATION 23 8.96e-01 -1.57e-02 9.61e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 25 8.92e-01 -1.57e-02 9.59e-01
RHOH GTPASE CYCLE 31 8.81e-01 -1.55e-02 9.56e-01
ANTIGEN PROCESSING CROSS PRESENTATION 72 8.30e-01 1.46e-02 9.28e-01
MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL 164 7.48e-01 -1.46e-02 8.86e-01
VEGFR2 MEDIATED CELL PROLIFERATION 12 9.32e-01 1.43e-02 9.76e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 9.24e-01 1.43e-02 9.74e-01
ION CHANNEL TRANSPORT 118 7.94e-01 1.39e-02 9.07e-01
RIPK1 MEDIATED REGULATED NECROSIS 29 9.06e-01 -1.27e-02 9.65e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 139 8.04e-01 -1.22e-02 9.14e-01
FLT3 SIGNALING 26 9.15e-01 -1.21e-02 9.69e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 30 9.12e-01 -1.17e-02 9.67e-01
GABA B RECEPTOR ACTIVATION 33 9.10e-01 -1.14e-02 9.67e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 93 8.53e-01 -1.11e-02 9.39e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 26 9.23e-01 1.09e-02 9.74e-01
M PHASE 312 7.51e-01 1.05e-02 8.87e-01
TRANSCRIPTIONAL REGULATION BY E2F6 23 9.32e-01 1.02e-02 9.76e-01
CHOLESTEROL BIOSYNTHESIS 26 9.29e-01 -1.01e-02 9.75e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 17 9.43e-01 -1.00e-02 9.77e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 28 9.27e-01 -9.97e-03 9.75e-01
TRANSLESION SYNTHESIS BY POLK 17 9.46e-01 -9.43e-03 9.77e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 9.59e-01 9.39e-03 9.79e-01
PROLONGED ERK ACTIVATION EVENTS 13 9.56e-01 8.87e-03 9.77e-01
G ALPHA Q SIGNALLING EVENTS 116 8.70e-01 8.78e-03 9.48e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 82 8.93e-01 -8.64e-03 9.59e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 9.40e-01 8.56e-03 9.77e-01
INTRINSIC PATHWAY FOR APOPTOSIS 34 9.32e-01 -8.46e-03 9.76e-01
ADAPTIVE IMMUNE SYSTEM 566 7.34e-01 -8.41e-03 8.75e-01
NONHOMOLOGOUS END JOINING NHEJ 31 9.37e-01 -8.17e-03 9.77e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 22 9.50e-01 7.75e-03 9.77e-01
DNA DOUBLE STRAND BREAK REPAIR 123 8.84e-01 7.65e-03 9.57e-01
REGULATION OF INSULIN SECRETION 49 9.28e-01 7.43e-03 9.75e-01
ARACHIDONIC ACID METABOLISM 33 9.45e-01 -6.99e-03 9.77e-01
G ALPHA Z SIGNALLING EVENTS 27 9.51e-01 -6.78e-03 9.77e-01
GPCR LIGAND BINDING 139 8.91e-01 6.76e-03 9.59e-01
RHOBTB2 GTPASE CYCLE 22 9.57e-01 -6.68e-03 9.77e-01
CARGO CONCENTRATION IN THE ER 29 9.53e-01 6.27e-03 9.77e-01
REGULATION OF TP53 ACTIVITY 145 9.00e-01 -6.06e-03 9.64e-01
SIGNALING BY ERBB4 32 9.55e-01 -5.76e-03 9.77e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 32 9.55e-01 -5.76e-03 9.77e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 17 9.68e-01 -5.62e-03 9.84e-01
CELLULAR HEXOSE TRANSPORT 13 9.73e-01 -5.46e-03 9.86e-01
PLATELET HOMEOSTASIS 64 9.44e-01 5.09e-03 9.77e-01
DEUBIQUITINATION 216 9.06e-01 -4.69e-03 9.65e-01
DNA REPLICATION 121 9.38e-01 -4.12e-03 9.77e-01
MUSCLE CONTRACTION 126 9.37e-01 4.09e-03 9.77e-01
G1 S TRANSITION 101 9.45e-01 3.97e-03 9.77e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 107 9.46e-01 -3.83e-03 9.77e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 51 9.62e-01 -3.81e-03 9.80e-01
ESR MEDIATED SIGNALING 102 9.50e-01 -3.61e-03 9.77e-01
S PHASE 140 9.45e-01 -3.40e-03 9.77e-01
G ALPHA I SIGNALLING EVENTS 129 9.53e-01 3.00e-03 9.77e-01
GABA RECEPTOR ACTIVATION 37 9.78e-01 -2.60e-03 9.90e-01
SIGNALING BY NTRKS 73 9.70e-01 -2.55e-03 9.84e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 76 9.70e-01 -2.50e-03 9.84e-01
HDACS DEACETYLATE HISTONES 29 9.82e-01 -2.46e-03 9.92e-01
ASPARAGINE N LINKED GLYCOSYLATION 241 9.50e-01 2.37e-03 9.77e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 9.87e-01 2.34e-03 9.93e-01
REGULATION OF TNFR1 SIGNALING 46 9.83e-01 1.76e-03 9.92e-01
SIGNALING BY NTRK1 TRKA 62 9.81e-01 -1.70e-03 9.92e-01
SIGNALING BY FGFR1 41 9.87e-01 -1.41e-03 9.93e-01
EFFECTS OF PIP2 HYDROLYSIS 22 9.94e-01 -9.08e-04 9.96e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1089 9.63e-01 8.54e-04 9.80e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 164 9.87e-01 -7.42e-04 9.93e-01
INTERLEUKIN 1 FAMILY SIGNALING 105 9.91e-01 -6.66e-04 9.95e-01
INSULIN RECEPTOR RECYCLING 24 9.97e-01 -4.71e-04 9.98e-01
TOLL LIKE RECEPTOR 4 TLR4 CASCADE 112 9.94e-01 -4.31e-04 9.96e-01
NOTCH HLH TRANSCRIPTION PATHWAY 22 9.99e-01 -8.36e-05 9.99e-01


Detailed Gene set reports



COMPLEX I BIOGENESIS
set COMPLEX I BIOGENESIS
setSize 58
pANOVA 5.55e-33
s.dist -0.907
p.adjustANOVA 9.99e-31


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufa9 -7782.5
Hspa9 -7763.5
Ndufa5 -7746.5
Ndufab1 -7698.5
Ndufs3 -7686.5
Ndufa10 -7685.5
Ndufs6 -7679.5
Ndufv2 -7672.5
Ndufs1 -7645.5
Ndufb8 -7633.5
Ndufs2 -7619.5
Ndufa3 -7593.5
Tmem186 -7569.5
Ndufs4 -7515.5
Ndufaf1 -7486.5
Ndufv3 -7479.5
Ndufb2 -7475.5
Ndufc1 -7471.5
Ndufs8 -7417.5
Ndufb9 -7407.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufa9 -7782.5
Hspa9 -7763.5
Ndufa5 -7746.5
Ndufab1 -7698.5
Ndufs3 -7686.5
Ndufa10 -7685.5
Ndufs6 -7679.5
Ndufv2 -7672.5
Ndufs1 -7645.5
Ndufb8 -7633.5
Ndufs2 -7619.5
Ndufa3 -7593.5
Tmem186 -7569.5
Ndufs4 -7515.5
Ndufaf1 -7486.5
Ndufv3 -7479.5
Ndufb2 -7475.5
Ndufc1 -7471.5
Ndufs8 -7417.5
Ndufb9 -7407.5
Ndufb4 -7406.5
Ndufa12 -7375.5
Ndufb10 -7326.5
Ndufa6 -7318.5
Ndufb6 -7304.5
Ndufb11 -7286.5
Ndufs5 -7258.5
Ndufc2 -7249.5
mt-Nd5 -7241.5
Ndufaf4 -7224.5
Ndufa8 -7188.5
Ndufb5 -7136.5
mt-Nd1 -7122.5
mt-Nd4 -7111.5
Ndufaf6 -7110.5
mt-Nd2 -7092.5
Acad9 -7087.5
mt-Nd6 -7086.5
Ndufa13 -7073.5
Nubpl -7043.5
Pyurf -7020.5
Tmem126b -7010.5
Ndufs7 -6951.5
Ndufv1 -6933.5
Ndufb3 -6925.5
Ndufa1 -6839.5
Ndufaf7 -6810.5
Ecsit -6589.5
Ndufaf5 -6466.5
Ndufa11 -6409.5
Ndufa7 -6304.5
Ndufa2 -6183.5
Ndufb7 -6145.5
Hscb -6041.5
Timmdc1 -5878.5
Ndufaf3 -5604.5
Ndufaf2 -5313.5
Lyrm2 -4015.5


CITRIC ACID CYCLE TCA CYCLE
set CITRIC ACID CYCLE TCA CYCLE
setSize 33
pANOVA 1.14e-18
s.dist -0.886
p.adjustANOVA 1.14e-16


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dlst -7780.5
Suclg1 -7732.5
Idh3a -7727.5
Acat1 -7712.5
Suclg2 -7708.5
Sdha -7707.5
Cs -7694.5
Nnt -7680.5
Idh3b -7678.5
Sucla2 -7638.5
Dld -7624.5
Ogdh -7608.5
Sdhd -7560.5
Sdhc -7541.5
Sdhb -7531.5
Fh1 -7529.5
Isca1 -7518.5
Idh3g -7349.5
Idh2 -7309.5
Mdh2 -7289.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dlst -7780.5
Suclg1 -7732.5
Idh3a -7727.5
Acat1 -7712.5
Suclg2 -7708.5
Sdha -7707.5
Cs -7694.5
Nnt -7680.5
Idh3b -7678.5
Sucla2 -7638.5
Dld -7624.5
Ogdh -7608.5
Sdhd -7560.5
Sdhc -7541.5
Sdhb -7531.5
Fh1 -7529.5
Isca1 -7518.5
Idh3g -7349.5
Idh2 -7309.5
Mdh2 -7289.5
Isca2 -7257.5
Nfs1 -7228.5
Aco2 -7213.5
Sirt3 -7200.5
Trap1 -7141.5
Sdhaf2 -6848.5
Iscu -6425.5
Fxn -6225.5
Sdhaf4 -5833.5
Mrps36 -5338.5
Sdhaf3 -4898.5
Sdhaf1 -4776.5
Lyrm4 2.5


BRANCHED CHAIN AMINO ACID CATABOLISM
set BRANCHED CHAIN AMINO ACID CATABOLISM
setSize 20
pANOVA 7.67e-12
s.dist -0.884
p.adjustANOVA 3.83e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hibadh -7779.5
Mccc1 -7768.5
Ivd -7765.5
Mccc2 -7760.5
Dbt -7745.5
Aldh6a1 -7740.5
Echs1 -7736.5
Auh -7718.5
Acat1 -7712.5
Bcat2 -7659.5
Bckdhb -7658.5
Dld -7624.5
Ppm1k -7576.5
Hsd17b10 -7548.5
Bckdha -7472.5
Acadsb -7324.5
Acad8 -7270.5
Hibch -7059.5
Bckdk -6695.5
Bcat1 5557.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hibadh -7779.5
Mccc1 -7768.5
Ivd -7765.5
Mccc2 -7760.5
Dbt -7745.5
Aldh6a1 -7740.5
Echs1 -7736.5
Auh -7718.5
Acat1 -7712.5
Bcat2 -7659.5
Bckdhb -7658.5
Dld -7624.5
Ppm1k -7576.5
Hsd17b10 -7548.5
Bckdha -7472.5
Acadsb -7324.5
Acad8 -7270.5
Hibch -7059.5
Bckdk -6695.5
Bcat1 5557.5


UBIQUINOL BIOSYNTHESIS
set UBIQUINOL BIOSYNTHESIS
setSize 11
pANOVA 5.03e-07
s.dist -0.875
p.adjustANOVA 1.1e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Coq5 -7654.5
Stard7 -7598.5
Coq9 -7557.5
Coq6 -7492.5
Coq2 -7455.5
Pdss2 -7442.5
Coq3 -7352.5
Pdss1 -7180.5
Coq7 -6668.5
Coq4 -5872.5
Hpdl -2965.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Coq5 -7654.5
Stard7 -7598.5
Coq9 -7557.5
Coq6 -7492.5
Coq2 -7455.5
Pdss2 -7442.5
Coq3 -7352.5
Pdss1 -7180.5
Coq7 -6668.5
Coq4 -5872.5
Hpdl -2965.5


PROTEIN LIPOYLATION
set PROTEIN LIPOYLATION
setSize 10
pANOVA 2.8e-06
s.dist -0.855
p.adjustANOVA 5.61e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dlst -7780.5
Dbt -7745.5
Ndufab1 -7698.5
Dlat -7564.5
Fdx1 -6717.5
Lias -6562.5
Lipt2 -6170.5
Nfu1 -5925.5
Gcsh -5471.5
Lipt1 -5283.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dlst -7780.5
Dbt -7745.5
Ndufab1 -7698.5
Dlat -7564.5
Fdx1 -6717.5
Lias -6562.5
Lipt2 -6170.5
Nfu1 -5925.5
Gcsh -5471.5
Lipt1 -5283.5


RESPIRATORY ELECTRON TRANSPORT
set RESPIRATORY ELECTRON TRANSPORT
setSize 124
pANOVA 1.76e-59
s.dist -0.843
p.adjustANOVA 7.93e-57


Top enriched genes
Top 20 genes
GeneID Gene Rank
Etfdh -7786.5
Ndufa9 -7782.5
Cox7a1 -7777.5
Etfa -7766.5
Hspa9 -7763.5
Ndufa5 -7746.5
Cox5a -7703.5
Ndufab1 -7698.5
Uqcrfs1 -7690.5
Ndufs3 -7686.5
Ndufa10 -7685.5
Ndufs6 -7679.5
Ndufv2 -7672.5
Uqcrc2 -7665.5
Ndufs1 -7645.5
Got1 -7644.5
Slc25a11 -7635.5
Ndufb8 -7633.5
Ndufs2 -7619.5
Ndufa3 -7593.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Etfdh -7786.5
Ndufa9 -7782.5
Cox7a1 -7777.5
Etfa -7766.5
Hspa9 -7763.5
Ndufa5 -7746.5
Cox5a -7703.5
Ndufab1 -7698.5
Uqcrfs1 -7690.5
Ndufs3 -7686.5
Ndufa10 -7685.5
Ndufs6 -7679.5
Ndufv2 -7672.5
Uqcrc2 -7665.5
Ndufs1 -7645.5
Got1 -7644.5
Slc25a11 -7635.5
Ndufb8 -7633.5
Ndufs2 -7619.5
Ndufa3 -7593.5
Tmem186 -7569.5
Etfb -7567.5
Ndufs4 -7515.5
Ndufaf1 -7486.5
Ndufv3 -7479.5
Ndufb2 -7475.5
Ndufc1 -7471.5
Uqcrc1 -7436.5
Slc25a12 -7434.5
Ndufs8 -7417.5
Ndufb9 -7407.5
Ndufb4 -7406.5
Coq10a -7397.5
Ndufa12 -7375.5
mt-Cytb -7373.5
Ttc19 -7345.5
Mdh1 -7342.5
mt-Co1 -7341.5
Cycs -7336.5
Tmem177 -7334.5
Ndufb10 -7326.5
Ndufa6 -7318.5
Ndufb6 -7304.5
Cox4i1 -7294.5
Mdh2 -7289.5
Ndufb11 -7286.5
Ndufa4 -7281.5
Ndufs5 -7258.5
Cyc1 -7255.5
Ndufc2 -7249.5
mt-Nd5 -7241.5
Cox6c -7238.5
Nfs1 -7228.5
Cox5b -7225.5
Ndufaf4 -7224.5
Cox15 -7202.5
Ndufa8 -7188.5
Timm21 -7163.5
Higd1a -7160.5
Cox7b -7157.5
Ndufb5 -7136.5
Cox7c -7135.5
Uqcrq -7130.5
mt-Nd1 -7122.5
mt-Nd4 -7111.5
Ndufaf6 -7110.5
Uqcrb -7102.5
mt-Nd2 -7092.5
Acad9 -7087.5
mt-Nd6 -7086.5
Ndufa13 -7073.5
Nubpl -7043.5
Pyurf -7020.5
Tmem126b -7010.5
Got2 -6959.5
Ndufs7 -6951.5
Ndufv1 -6933.5
Ndufb3 -6925.5
Slc25a13 -6901.5
Cox7a2l -6879.5
Cox6b1 -6861.5
Ndufa1 -6839.5
Ndufaf7 -6810.5
Uqcrh -6804.5
Cox6a2 -6766.5
Smim20 -6760.5
Hccs -6749.5
Sco1 -6709.5
Cox11 -6690.5
Cox7a2 -6681.5
Ecsit -6589.5
Ndufaf5 -6466.5
Iscu -6425.5
Ndufa11 -6409.5
Lyrm7 -6367.5
Slc25a22 -6352.5
Ndufa7 -6304.5
Fxn -6225.5
Coa5 -6192.5
Ndufa2 -6183.5
Surf1 -6162.5
Ndufb7 -6145.5
Hscb -6041.5
Cox14 -5886.5
Timmdc1 -5878.5
Ndufaf3 -5604.5
Cox6b2 -5595.5
Higd2a -5562.5
Cox20 -5404.5
Ndufaf2 -5313.5
Cox4i2 -5203.5
Sco2 -4574.5
Uqcr10 -4460.5
Cox18 -4414.5
Cmc1 -4408.5
Cox17 -4322.5
Lyrm2 -4015.5
Cox6a1 -3949.5
Coa3 -3139.5
Coq10b -2572.5
Cox8a -1185.5
Lyrm4 2.5
Cox16 30.5
Cox19 6776.5


COMPLEX III ASSEMBLY
set COMPLEX III ASSEMBLY
setSize 17
pANOVA 3.21e-09
s.dist -0.829
p.adjustANOVA 1.03e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hspa9 -7763.5
Uqcrfs1 -7690.5
Uqcrc2 -7665.5
Uqcrc1 -7436.5
mt-Cytb -7373.5
Ttc19 -7345.5
Cyc1 -7255.5
Nfs1 -7228.5
Uqcrq -7130.5
Uqcrb -7102.5
Uqcrh -6804.5
Iscu -6425.5
Lyrm7 -6367.5
Fxn -6225.5
Hscb -6041.5
Uqcr10 -4460.5
Lyrm4 2.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspa9 -7763.5
Uqcrfs1 -7690.5
Uqcrc2 -7665.5
Uqcrc1 -7436.5
mt-Cytb -7373.5
Ttc19 -7345.5
Cyc1 -7255.5
Nfs1 -7228.5
Uqcrq -7130.5
Uqcrb -7102.5
Uqcrh -6804.5
Iscu -6425.5
Lyrm7 -6367.5
Fxn -6225.5
Hscb -6041.5
Uqcr10 -4460.5
Lyrm4 2.5


MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE
set MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE
setSize 18
pANOVA 1.12e-09
s.dist -0.829
p.adjustANOVA 3.73e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acat1 -7712.5
Sdha -7707.5
Sdhd -7560.5
Sdhc -7541.5
Sdhb -7531.5
Isca1 -7518.5
Idh2 -7309.5
Isca2 -7257.5
Nfs1 -7228.5
Aco2 -7213.5
Sirt3 -7200.5
Sdhaf2 -6848.5
Iscu -6425.5
Fxn -6225.5
Sdhaf4 -5833.5
Sdhaf3 -4898.5
Sdhaf1 -4776.5
Lyrm4 2.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acat1 -7712.5
Sdha -7707.5
Sdhd -7560.5
Sdhc -7541.5
Sdhb -7531.5
Isca1 -7518.5
Idh2 -7309.5
Isca2 -7257.5
Nfs1 -7228.5
Aco2 -7213.5
Sirt3 -7200.5
Sdhaf2 -6848.5
Iscu -6425.5
Fxn -6225.5
Sdhaf4 -5833.5
Sdhaf3 -4898.5
Sdhaf1 -4776.5
Lyrm4 2.5


MITOCHONDRIAL FATTY ACID BETA OXIDATION
set MITOCHONDRIAL FATTY ACID BETA OXIDATION
setSize 33
pANOVA 2.49e-16
s.dist -0.824
p.adjustANOVA 2.04e-14


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hadh -7789.5
Acaa2 -7778.5
Decr1 -7775.5
Pcca -7764.5
Hadhb -7756.5
Mcee -7737.5
Echs1 -7736.5
Eci1 -7725.5
Ndufab1 -7698.5
Acad11 -7683.5
Hadha -7666.5
Acadm -7609.5
Acadl -7537.5
Pccb -7517.5
Acadvl -7505.5
Acot1 -7501.5
Acot2 -7351.5
Acads -7234.5
Acsf2 -7192.5
Acot13 -7171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hadh -7789.5
Acaa2 -7778.5
Decr1 -7775.5
Pcca -7764.5
Hadhb -7756.5
Mcee -7737.5
Echs1 -7736.5
Eci1 -7725.5
Ndufab1 -7698.5
Acad11 -7683.5
Hadha -7666.5
Acadm -7609.5
Acadl -7537.5
Pccb -7517.5
Acadvl -7505.5
Acot1 -7501.5
Acot2 -7351.5
Acads -7234.5
Acsf2 -7192.5
Acot13 -7171.5
Acot11 -7114.5
Acot7 -7098.5
Mecr -6977.5
Dbi -6864.5
Mmaa -6835.5
Mcat -6705.5
Acot3 -6542.5
Pctp -6133.5
Them4 -5719.5
Acad10 -5108.5
Acbd6 -2964.5
Acot12 301.5
Acot9 6907.5


AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT
set AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT
setSize 202
pANOVA 3.09e-83
s.dist -0.786
p.adjustANOVA 2.78e-80


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adhfe1 -7793.5
Pm20d1 -7787.5
Etfdh -7786.5
Ndufa9 -7782.5
Dlst -7780.5
Cox7a1 -7777.5
Etfa -7766.5
Hspa9 -7763.5
Ndufa5 -7746.5
Suclg1 -7732.5
Idh3a -7727.5
Acat1 -7712.5
Suclg2 -7708.5
Sdha -7707.5
Cox5a -7703.5
Ldhb -7702.5
Ndufab1 -7698.5
Pdhx -7696.5
Cs -7694.5
Uqcrfs1 -7690.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adhfe1 -7793.5
Pm20d1 -7787.5
Etfdh -7786.5
Ndufa9 -7782.5
Dlst -7780.5
Cox7a1 -7777.5
Etfa -7766.5
Hspa9 -7763.5
Ndufa5 -7746.5
Suclg1 -7732.5
Idh3a -7727.5
Acat1 -7712.5
Suclg2 -7708.5
Sdha -7707.5
Cox5a -7703.5
Ldhb -7702.5
Ndufab1 -7698.5
Pdhx -7696.5
Cs -7694.5
Uqcrfs1 -7690.5
Ndufs3 -7686.5
Ndufa10 -7685.5
Nnt -7680.5
Ndufs6 -7679.5
Idh3b -7678.5
Ndufv2 -7672.5
Uqcrc2 -7665.5
Ndufs1 -7645.5
Got1 -7644.5
Fahd1 -7642.5
Sucla2 -7638.5
Slc25a11 -7635.5
Ndufb8 -7633.5
Dld -7624.5
Ndufs2 -7619.5
Pdpr -7613.5
Ogdh -7608.5
Ndufa3 -7593.5
Me3 -7579.5
Tmem186 -7569.5
Etfb -7567.5
Dlat -7564.5
Sdhd -7560.5
Sdhc -7541.5
L2hgdh -7540.5
Sdhb -7531.5
Fh1 -7529.5
Isca1 -7518.5
Ndufs4 -7515.5
Gpt -7508.5
Ndufaf1 -7486.5
Ndufv3 -7479.5
Ndufb2 -7475.5
Ndufc1 -7471.5
Vdac1 -7461.5
Uqcrc1 -7436.5
Slc25a12 -7434.5
Ndufs8 -7417.5
Ndufb9 -7407.5
Ndufb4 -7406.5
Coq10a -7397.5
Pdha1 -7382.5
Ndufa12 -7375.5
Slc25a4 -7374.5
mt-Cytb -7373.5
Pdp2 -7368.5
Idh3g -7349.5
Ttc19 -7345.5
Mdh1 -7342.5
mt-Co1 -7341.5
Cycs -7336.5
Tmem177 -7334.5
Ndufb10 -7326.5
Pdhb -7319.5
Ndufa6 -7318.5
Idh2 -7309.5
Ndufb6 -7304.5
Cox4i1 -7294.5
Mdh2 -7289.5
Ndufb11 -7286.5
Ndufa4 -7281.5
Gstz1 -7264.5
Ndufs5 -7258.5
Isca2 -7257.5
Cyc1 -7255.5
Ndufc2 -7249.5
mt-Nd5 -7241.5
Cox6c -7238.5
Nfs1 -7228.5
Cox5b -7225.5
Ndufaf4 -7224.5
Aco2 -7213.5
Gid4 -7209.5
Cox15 -7202.5
Pdk2 -7201.5
Sirt3 -7200.5
Ndufa8 -7188.5
Timm21 -7163.5
Higd1a -7160.5
Cox7b -7157.5
Trap1 -7141.5
Ndufb5 -7136.5
Cox7c -7135.5
Uqcrq -7130.5
mt-Nd1 -7122.5
mt-Nd4 -7111.5
Ndufaf6 -7110.5
Uqcrb -7102.5
mt-Nd2 -7092.5
Acad9 -7087.5
mt-Nd6 -7086.5
Ndufa13 -7073.5
Nubpl -7043.5
Pyurf -7020.5
Me1 -7018.5
Tmem126b -7010.5
Got2 -6959.5
D2hgdh -6956.5
Ndufs7 -6951.5
Ndufv1 -6933.5
Ndufb3 -6925.5
Slc25a13 -6901.5
Cox7a2l -6879.5
Cox6b1 -6861.5
Sdhaf2 -6848.5
Ndufa1 -6839.5
Ndufaf7 -6810.5
Uqcrh -6804.5
Cox6a2 -6766.5
Smim20 -6760.5
Hccs -6749.5
Sco1 -6709.5
Cox11 -6690.5
Cox7a2 -6681.5
Ecsit -6589.5
Pkm -6577.5
Pdk1 -6558.5
Pcx -6534.5
Ndufaf5 -6466.5
Iscu -6425.5
Ranbp9 -6411.5
Ndufa11 -6409.5
Lyrm7 -6367.5
Slc25a22 -6352.5
Ndufa7 -6304.5
Fxn -6225.5
Coa5 -6192.5
Ndufa2 -6183.5
Surf1 -6162.5
Ndufb7 -6145.5
Hscb -6041.5
Cox14 -5886.5
Timmdc1 -5878.5
Sdhaf4 -5833.5
Glo1 -5785.5
Pgam5 -5698.5
Rmnd5a -5637.5
Ndufaf3 -5604.5
Cox6b2 -5595.5
Higd2a -5562.5
Sirt4 -5456.5
Cox20 -5404.5
Mrps36 -5338.5
Ndufaf2 -5313.5
Cox4i2 -5203.5
Ucp3 -5134.5
Gid8 -5117.5
Armc8 -4929.5
Sdhaf3 -4898.5
Sdhaf1 -4776.5
Ldha -4720.5
Pdp1 -4680.5
Sco2 -4574.5
Uqcr10 -4460.5
Cox18 -4414.5
Cmc1 -4408.5
Mkln1 -4361.5
Cox17 -4322.5
Nek1 -4082.5
Lyrm2 -4015.5
Cox6a1 -3949.5
Uba52 -3735.5
Coa3 -3139.5
Coq10b -2572.5
Ubc -2084.5
Maea -1825.5
Ldhal6b -1655.5
Ubb -1647.5
Hagh -1200.5
Cox8a -1185.5
Rps27a -996.5
Lyrm4 2.5
Cox16 30.5
Wdr26 652.5
Slc25a27 1755.5
Pdk4 1859.5
Slc25a14 3182.5
Ucp2 3317.5
Me2 4725.5
Rmnd5b 5434.5
Cox19 6776.5
Pdk3 7005.5


MITOCHONDRIAL TRANSLATION
set MITOCHONDRIAL TRANSLATION
setSize 87
pANOVA 3.76e-36
s.dist -0.777
p.adjustANOVA 8.46e-34


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mrps9 -7710.5
Mrpl45 -7675.5
Mrps35 -7643.5
Mrpl42 -7617.5
Gfm1 -7582.5
Mrps31 -7553.5
Mrps2 -7544.5
Gfm2 -7528.5
Mrpl46 -7502.5
Ptcd3 -7489.5
Mrpl9 -7465.5
Mrpl21 -7420.5
Mrpl28 -7405.5
Mrpl30 -7395.5
Mrpl39 -7388.5
Mrps27 -7362.5
Mrpl37 -7337.5
Mrpl51 -7305.5
Mrpl35 -7245.5
Mrps15 -7230.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mrps9 -7710.5
Mrpl45 -7675.5
Mrps35 -7643.5
Mrpl42 -7617.5
Gfm1 -7582.5
Mrps31 -7553.5
Mrps2 -7544.5
Gfm2 -7528.5
Mrpl46 -7502.5
Ptcd3 -7489.5
Mrpl9 -7465.5
Mrpl21 -7420.5
Mrpl28 -7405.5
Mrpl30 -7395.5
Mrpl39 -7388.5
Mrps27 -7362.5
Mrpl37 -7337.5
Mrpl51 -7305.5
Mrpl35 -7245.5
Mrps15 -7230.5
Mrpl19 -7187.5
Mrpl47 -7184.5
Dap3 -7162.5
Mrpl18 -7154.5
Mrpl1 -7115.5
Mrrf -7096.5
Mrps25 -7085.5
Mrps5 -7078.5
Mrpl15 -7070.5
Mrpl3 -7054.5
Mrpl44 -7053.5
Mrps21 -7047.5
Mrpl41 -7001.5
Mrps17 -6999.5
Mrpl50 -6997.5
Mrps30 -6979.5
Eral1 -6936.5
Mrpl13 -6926.5
Mrpl16 -6921.5
Mrps28 -6892.5
Mrpl14 -6873.5
Oxa1l -6826.5
Mrpl55 -6818.5
Mrps7 -6800.5
Mrps18a -6780.5
Mrps22 -6779.5
Gadd45gip1 -6772.5
Mrpl12 -6700.5
Mrps14 -6676.5
Mrpl34 -6661.5
Mrpl4 -6653.5
Mrpl22 -6499.5
Mrps16 -6420.5
Mrpl11 -6369.5
Mrpl10 -6287.5
Mrpl49 -6232.5
Mrpl38 -6204.5
Mrpl2 -6105.5
Mrps24 -6091.5
Aurkaip1 -6058.5
Mrps18c -6052.5
Mrps33 -5975.5
Mtrf1l -5971.5
Mrpl32 -5953.5
Mrps23 -5908.5
Chchd1 -5905.5
Mrps11 -5880.5
Mrpl43 -5641.5
Mrps36 -5338.5
Mrpl27 -5327.5
Mrpl36 -5185.5
Mrps34 -5004.5
Mrpl40 -4911.5
Mrps18b -4853.5
Mrpl17 -4847.5
Mrpl24 -4518.5
Mrps12 -4282.5
Mrpl20 -4235.5
Mrpl23 -4007.5
Mrpl57 -3823.5
Mrps26 -3319.5
Mrps6 -2730.5
Mrpl54 -2632.5
Mrpl48 -1441.5
Mrpl52 554.5
Mrps10 2607.5
Mrpl33 3611.5


MITOCHONDRIAL PROTEIN DEGRADATION
set MITOCHONDRIAL PROTEIN DEGRADATION
setSize 70
pANOVA 2.72e-28
s.dist -0.761
p.adjustANOVA 4.08e-26


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hadh -7789.5
Hspa9 -7763.5
Dbt -7745.5
Idh3a -7727.5
Eci1 -7725.5
Nadk2 -7715.5
Acat1 -7712.5
Suclg2 -7708.5
Cox5a -7703.5
Ldhd -7701.5
Cs -7694.5
Ndufs3 -7686.5
Uqcrc2 -7665.5
Ndufs1 -7645.5
Dld -7624.5
Hspd1 -7621.5
Ogdh -7608.5
Fech -7592.5
Hsd17b10 -7548.5
Mrps2 -7544.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hadh -7789.5
Hspa9 -7763.5
Dbt -7745.5
Idh3a -7727.5
Eci1 -7725.5
Nadk2 -7715.5
Acat1 -7712.5
Suclg2 -7708.5
Cox5a -7703.5
Ldhd -7701.5
Cs -7694.5
Ndufs3 -7686.5
Uqcrc2 -7665.5
Ndufs1 -7645.5
Dld -7624.5
Hspd1 -7621.5
Ogdh -7608.5
Fech -7592.5
Hsd17b10 -7548.5
Mrps2 -7544.5
Ech1 -7535.5
Fh1 -7529.5
Oxct1 -7521.5
Clpx -7519.5
Pccb -7517.5
Acot1 -7501.5
Ndufv3 -7479.5
Iars2 -7456.5
Glud1 -7423.5
Pdha1 -7382.5
Acot2 -7351.5
mt-Co1 -7341.5
Afg3l2 -7325.5
Acadsb -7324.5
Pmpca -7323.5
Pdhb -7319.5
Idh2 -7309.5
Mdh2 -7289.5
Acad8 -7270.5
Cox5b -7225.5
Aco2 -7213.5
Clpp -7205.5
Uqcrq -7130.5
Ndufa13 -7073.5
Alas1 -6948.5
Tfam -6934.5
Ndufv1 -6933.5
Oxsm -6764.5
Mrpl12 -6700.5
Pdk1 -6558.5
Acot3 -6542.5
Hmgcs2 -6408.5
Prkaca -6357.5
Shmt2 -6208.5
Ndufa2 -6183.5
Spg7 -6158.5
Mrpl32 -5953.5
Aldh2 -5608.5
Htra2 -4802.5
Aldh1b1 -4786.5
Slc25a5 -4654.5
Lonp1 -4109.5
Ssbp1 -2721.5
Bdh1 -1278.5
Smdt1 127.5
Mrps10 2607.5
Aldh18a1 4077.5
Me2 4725.5
App 6935.5
Star 7439.5


MITOCHONDRIAL BIOGENESIS
set MITOCHONDRIAL BIOGENESIS
setSize 10
pANOVA 5.36e-05
s.dist -0.738
p.adjustANOVA 0.000805


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sod2 -7794.5
Sirt5 -7460.5
Glud1 -7423.5
Cycs -7336.5
Idh2 -7309.5
Sirt3 -7200.5
Gabpa -5968.5
Sirt4 -5456.5
Gabpb1 -1311.5
Acss2 -686.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sod2 -7794.5
Sirt5 -7460.5
Glud1 -7423.5
Cycs -7336.5
Idh2 -7309.5
Sirt3 -7200.5
Gabpa -5968.5
Sirt4 -5456.5
Gabpb1 -1311.5
Acss2 -686.5


TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS
set TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS
setSize 10
pANOVA 5.36e-05
s.dist -0.738
p.adjustANOVA 0.000805


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sod2 -7794.5
Sirt5 -7460.5
Glud1 -7423.5
Cycs -7336.5
Idh2 -7309.5
Sirt3 -7200.5
Gabpa -5968.5
Sirt4 -5456.5
Gabpb1 -1311.5
Acss2 -686.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sod2 -7794.5
Sirt5 -7460.5
Glud1 -7423.5
Cycs -7336.5
Idh2 -7309.5
Sirt3 -7200.5
Gabpa -5968.5
Sirt4 -5456.5
Gabpb1 -1311.5
Acss2 -686.5


COLLAGEN CHAIN TRIMERIZATION
set COLLAGEN CHAIN TRIMERIZATION
setSize 34
pANOVA 1.31e-13
s.dist 0.733
p.adjustANOVA 7.39e-12


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col22a1 7259.5
Col4a4 7256.5
Col16a1 7242.5
Col1a2 7112.5
Col15a1 7067.5
Col8a1 7060.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Col9a2 6879.5
Col3a1 6825.5
Col1a1 6801.5
Col20a1 6720.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col22a1 7259.5
Col4a4 7256.5
Col16a1 7242.5
Col1a2 7112.5
Col15a1 7067.5
Col8a1 7060.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Col9a2 6879.5
Col3a1 6825.5
Col1a1 6801.5
Col20a1 6720.5
Col5a1 6613.5
Col6a3 6398.5
Col18a1 5446.5
Col4a1 5401.5
Col13a1 5244.5
Col26a1 5088.5
Col4a2 4843.5
Col4a6 4829.5
Col28a1 3652.5
Col11a2 3368.5
Col23a1 908.5
Col25a1 -1726.5
Col5a3 -2248.5
Col6a6 -6117.5


MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
set MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
setSize 10
pANOVA 6.33e-05
s.dist -0.73
p.adjustANOVA 0.000934


Top enriched genes
Top 20 genes
GeneID Gene Rank
Isca1 -7518.5
Isca2 -7257.5
Nfs1 -7228.5
Fdx1 -6717.5
Iscu -6425.5
Fxn -6225.5
Hscb -6041.5
Fdxr -5162.5
Glrx5 -4832.5
Lyrm4 2.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Isca1 -7518.5
Isca2 -7257.5
Nfs1 -7228.5
Fdx1 -6717.5
Iscu -6425.5
Fxn -6225.5
Hscb -6041.5
Fdxr -5162.5
Glrx5 -4832.5
Lyrm4 2.5


COMPLEX IV ASSEMBLY
set COMPLEX IV ASSEMBLY
setSize 38
pANOVA 3.85e-14
s.dist -0.709
p.adjustANOVA 2.31e-12


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cox7a1 -7777.5
Cox5a -7703.5
Coq10a -7397.5
mt-Co1 -7341.5
Tmem177 -7334.5
Cox4i1 -7294.5
Ndufa4 -7281.5
Cox6c -7238.5
Cox5b -7225.5
Cox15 -7202.5
Timm21 -7163.5
Higd1a -7160.5
Cox7b -7157.5
Cox7c -7135.5
Cox7a2l -6879.5
Cox6b1 -6861.5
Cox6a2 -6766.5
Smim20 -6760.5
Sco1 -6709.5
Cox11 -6690.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cox7a1 -7777.5
Cox5a -7703.5
Coq10a -7397.5
mt-Co1 -7341.5
Tmem177 -7334.5
Cox4i1 -7294.5
Ndufa4 -7281.5
Cox6c -7238.5
Cox5b -7225.5
Cox15 -7202.5
Timm21 -7163.5
Higd1a -7160.5
Cox7b -7157.5
Cox7c -7135.5
Cox7a2l -6879.5
Cox6b1 -6861.5
Cox6a2 -6766.5
Smim20 -6760.5
Sco1 -6709.5
Cox11 -6690.5
Cox7a2 -6681.5
Coa5 -6192.5
Surf1 -6162.5
Cox14 -5886.5
Cox6b2 -5595.5
Higd2a -5562.5
Cox20 -5404.5
Cox4i2 -5203.5
Sco2 -4574.5
Cox18 -4414.5
Cmc1 -4408.5
Cox17 -4322.5
Cox6a1 -3949.5
Coa3 -3139.5
Coq10b -2572.5
Cox8a -1185.5
Cox16 30.5
Cox19 6776.5


CROSSLINKING OF COLLAGEN FIBRILS
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 18
pANOVA 3.64e-07
s.dist 0.692
p.adjustANOVA 8.18e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col4a3 7307.5
Col4a5 7299.5
Col4a4 7256.5
Col1a2 7112.5
Loxl3 7086.5
Loxl2 7079.5
Pcolce 6881.5
Col1a1 6801.5
Bmp1 6565.5
Lox 6388.5
Loxl1 6192.5
Loxl4 6099.5
Col4a1 5401.5
Tll1 5176.5
Col4a2 4843.5
Col4a6 4829.5
Tll2 -4614.5
Pxdn -5990.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col4a3 7307.5
Col4a5 7299.5
Col4a4 7256.5
Col1a2 7112.5
Loxl3 7086.5
Loxl2 7079.5
Pcolce 6881.5
Col1a1 6801.5
Bmp1 6565.5
Lox 6388.5
Loxl1 6192.5
Loxl4 6099.5
Col4a1 5401.5
Tll1 5176.5
Col4a2 4843.5
Col4a6 4829.5
Tll2 -4614.5
Pxdn -5990.5


HEME BIOSYNTHESIS
set HEME BIOSYNTHESIS
setSize 12
pANOVA 4.34e-05
s.dist -0.682
p.adjustANOVA 0.000673


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fech -7592.5
Cox10 -7440.5
Alad -7277.5
Cox15 -7202.5
Alas1 -6948.5
Hmbs -6783.5
Uros -6771.5
Urod -6640.5
Cpox -6353.5
Alas2 -1531.5
Ppox -1183.5
Alb 1313.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fech -7592.5
Cox10 -7440.5
Alad -7277.5
Cox15 -7202.5
Alas1 -6948.5
Hmbs -6783.5
Uros -6771.5
Urod -6640.5
Cpox -6353.5
Alas2 -1531.5
Ppox -1183.5
Alb 1313.5


MET ACTIVATES PTK2 SIGNALING
set MET ACTIVATES PTK2 SIGNALING
setSize 18
pANOVA 5.66e-07
s.dist 0.681
p.adjustANOVA 1.21e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col11a1 7324.5
Col5a2 7277.5
Src 7217.5
Col1a2 7112.5
Met 6971.5
Col3a1 6825.5
Col1a1 6801.5
Fn1 6674.5
Col5a1 6613.5
Itga2 6287.5
Itgb1 6225.5
Itga3 5607.5
Lama4 3800.5
Col11a2 3368.5
Megf6 2608.5
Hgf 2062.5
Ptk2 -391.5
Col5a3 -2248.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col11a1 7324.5
Col5a2 7277.5
Src 7217.5
Col1a2 7112.5
Met 6971.5
Col3a1 6825.5
Col1a1 6801.5
Fn1 6674.5
Col5a1 6613.5
Itga2 6287.5
Itgb1 6225.5
Itga3 5607.5
Lama4 3800.5
Col11a2 3368.5
Megf6 2608.5
Hgf 2062.5
Ptk2 -391.5
Col5a3 -2248.5


REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
set REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize 14
pANOVA 1.08e-05
s.dist -0.679
p.adjustANOVA 0.000203


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pdhx -7696.5
Dld -7624.5
Pdpr -7613.5
Dlat -7564.5
Pdha1 -7382.5
Pdp2 -7368.5
Pdhb -7319.5
Gstz1 -7264.5
Pdk2 -7201.5
Pdk1 -6558.5
Sirt4 -5456.5
Pdp1 -4680.5
Pdk4 1859.5
Pdk3 7005.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdhx -7696.5
Dld -7624.5
Pdpr -7613.5
Dlat -7564.5
Pdha1 -7382.5
Pdp2 -7368.5
Pdhb -7319.5
Gstz1 -7264.5
Pdk2 -7201.5
Pdk1 -6558.5
Sirt4 -5456.5
Pdp1 -4680.5
Pdk4 1859.5
Pdk3 7005.5


BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS
set BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS
setSize 11
pANOVA 0.000118
s.dist -0.67
p.adjustANOVA 0.00166


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acox1 -7669.5
Eci2 -7657.5
Hsd17b4 -7458.5
Mlycd -6985.5
Ehhadh -6680.5
Abcd1 -6415.5
Acot4 -5724.5
Decr2 -5240.5
Acot6 -3310.5
Acot8 -597.5
Acaa1b -373.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acox1 -7669.5
Eci2 -7657.5
Hsd17b4 -7458.5
Mlycd -6985.5
Ehhadh -6680.5
Abcd1 -6415.5
Acot4 -5724.5
Decr2 -5240.5
Acot6 -3310.5
Acot8 -597.5
Acaa1b -373.5


CS DS DEGRADATION
set CS DS DEGRADATION
setSize 11
pANOVA 0.000118
s.dist 0.67
p.adjustANOVA 0.00166


Top enriched genes
Top 20 genes
GeneID Gene Rank
Bgn 7159.5
Dcn 7102.5
Cspg4 7055.5
Vcan 6906.5
Arsb 6729.5
Hyal1 6393.5
Hexb 6262.5
Hexa 6102.5
Ids 3831.5
Cspg5 2471.5
Idua -5790.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bgn 7159.5
Dcn 7102.5
Cspg4 7055.5
Vcan 6906.5
Arsb 6729.5
Hyal1 6393.5
Hexb 6262.5
Hexa 6102.5
Ids 3831.5
Cspg5 2471.5
Idua -5790.5


COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
set COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
setSize 53
pANOVA 9.9e-17
s.dist 0.659
p.adjustANOVA 8.91e-15


Top enriched genes
Top 20 genes
GeneID Gene Rank
P3h2 7439.5
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col22a1 7259.5
Col4a4 7256.5
Col16a1 7242.5
Col1a2 7112.5
Col15a1 7067.5
Col8a1 7060.5
Pcolce2 7041.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Pcolce 6881.5
Col9a2 6879.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
P3h2 7439.5
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col22a1 7259.5
Col4a4 7256.5
Col16a1 7242.5
Col1a2 7112.5
Col15a1 7067.5
Col8a1 7060.5
Pcolce2 7041.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Pcolce 6881.5
Col9a2 6879.5
P3h3 6865.5
Adamts2 6841.5
P4ha1 6829.5
Col3a1 6825.5
Col1a1 6801.5
Col20a1 6720.5
Col5a1 6613.5
Bmp1 6565.5
Plod2 6408.5
Col6a3 6398.5
Adamts14 5846.5
Col18a1 5446.5
Col4a1 5401.5
P4hb 5325.5
Plod3 5321.5
Col13a1 5244.5
Tll1 5176.5
Col26a1 5088.5
Col4a2 4843.5
Col4a6 4829.5
Serpinh1 4119.5
Col28a1 3652.5
Colgalt1 3585.5
Col11a2 3368.5
Plod1 2663.5
Col23a1 908.5
Col25a1 -1726.5
Colgalt2 -1962.5
Col5a3 -2248.5
P4ha2 -3947.5
Adamts3 -4018.5
Tll2 -4614.5
Col6a6 -6117.5


LAMININ INTERACTIONS
set LAMININ INTERACTIONS
setSize 15
pANOVA 1.42e-05
s.dist 0.647
p.adjustANOVA 0.000256


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col4a3 7307.5
Col4a5 7299.5
Col4a4 7256.5
Itga7 6293.5
Itgb1 6225.5
Itga3 5607.5
Col4a1 5401.5
Nid1 4872.5
Col4a2 4843.5
Col4a6 4829.5
Itgb4 3931.5
Lama4 3800.5
Nid2 3636.5
Megf6 2608.5
Itga6 -2635.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col4a3 7307.5
Col4a5 7299.5
Col4a4 7256.5
Itga7 6293.5
Itgb1 6225.5
Itga3 5607.5
Col4a1 5401.5
Nid1 4872.5
Col4a2 4843.5
Col4a6 4829.5
Itgb4 3931.5
Lama4 3800.5
Nid2 3636.5
Megf6 2608.5
Itga6 -2635.5


ECM PROTEOGLYCANS
set ECM PROTEOGLYCANS
setSize 35
pANOVA 4.73e-11
s.dist 0.642
p.adjustANOVA 1.93e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col5a2 7277.5
Bgn 7159.5
Col1a2 7112.5
Dcn 7102.5
Comp 7063.5
Itga9 7059.5
Itgav 7044.5
Col6a2 6990.5
App 6935.5
Vcan 6906.5
Col6a1 6887.5
Col9a2 6879.5
Col3a1 6825.5
Col1a1 6801.5
Fn1 6674.5
Col5a1 6613.5
Serpine1 6577.5
Tnc 6533.5
Col6a3 6398.5
Itga7 6293.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col5a2 7277.5
Bgn 7159.5
Col1a2 7112.5
Dcn 7102.5
Comp 7063.5
Itga9 7059.5
Itgav 7044.5
Col6a2 6990.5
App 6935.5
Vcan 6906.5
Col6a1 6887.5
Col9a2 6879.5
Col3a1 6825.5
Col1a1 6801.5
Fn1 6674.5
Col5a1 6613.5
Serpine1 6577.5
Tnc 6533.5
Col6a3 6398.5
Itga7 6293.5
Itga2 6287.5
Sparc 6237.5
Itgb1 6225.5
Matn4 5944.5
Tnr 5610.5
Itga8 5355.5
Tnxb 5180.5
Itgb3 4215.5
Itgax 3098.5
Itga2b 798.5
Agrn 399.5
Col5a3 -2248.5
Itgb6 -6093.5
Col6a6 -6117.5
Vtn -7215.5


METABOLISM OF COFACTORS
set METABOLISM OF COFACTORS
setSize 23
pANOVA 2.35e-07
s.dist -0.623
p.adjustANOVA 5.56e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Coq5 -7654.5
Stard7 -7598.5
Coq9 -7557.5
Coq6 -7492.5
Coq2 -7455.5
Pdss2 -7442.5
Coq3 -7352.5
Pdss1 -7180.5
Gchfr -6940.5
Coq7 -6668.5
Idh1 -6315.5
Aco1 -5954.5
Akt1 -5946.5
Coq4 -5872.5
Calm1 -5245.5
Nos3 -4396.5
Pts -4024.5
Spr -3418.5
Calm3 -3155.5
Hpdl -2965.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Coq5 -7654.5
Stard7 -7598.5
Coq9 -7557.5
Coq6 -7492.5
Coq2 -7455.5
Pdss2 -7442.5
Coq3 -7352.5
Pdss1 -7180.5
Gchfr -6940.5
Coq7 -6668.5
Idh1 -6315.5
Aco1 -5954.5
Akt1 -5946.5
Coq4 -5872.5
Calm1 -5245.5
Nos3 -4396.5
Pts -4024.5
Spr -3418.5
Calm3 -3155.5
Hpdl -2965.5
Gch1 93.5
Calm2 1781.5
Hsp90aa1 5718.5


KERATAN SULFATE DEGRADATION
set KERATAN SULFATE DEGRADATION
setSize 12
pANOVA 2e-04
s.dist 0.62
p.adjustANOVA 0.00257


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fmod 7115.5
Prelp 6756.5
Galns 6740.5
Omd 6661.5
Lum 6544.5
Hexb 6262.5
Hexa 6102.5
Glb1l 5799.5
Ogn 4793.5
Glb1 1931.5
Glb1l2 1700.5
Gns -5861.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fmod 7115.5
Prelp 6756.5
Galns 6740.5
Omd 6661.5
Lum 6544.5
Hexb 6262.5
Hexa 6102.5
Glb1l 5799.5
Ogn 4793.5
Glb1 1931.5
Glb1l2 1700.5
Gns -5861.5


NCAM1 INTERACTIONS
set NCAM1 INTERACTIONS
setSize 16
pANOVA 1.8e-05
s.dist 0.619
p.adjustANOVA 0.000311


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Col6a2 6990.5
Col6a1 6887.5
Col9a2 6879.5
Col3a1 6825.5
Col5a1 6613.5
Col6a3 6398.5
Col4a1 5401.5
St8sia2 5280.5
Col4a2 4843.5
Col5a3 -2248.5
St8sia4 -4284.5
Col6a6 -6117.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Col6a2 6990.5
Col6a1 6887.5
Col9a2 6879.5
Col3a1 6825.5
Col5a1 6613.5
Col6a3 6398.5
Col4a1 5401.5
St8sia2 5280.5
Col4a2 4843.5
Col5a3 -2248.5
St8sia4 -4284.5
Col6a6 -6117.5


NON INTEGRIN MEMBRANE ECM INTERACTIONS
set NON INTEGRIN MEMBRANE ECM INTERACTIONS
setSize 30
pANOVA 6.5e-09
s.dist 0.612
p.adjustANOVA 2.02e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Sdc2 7146.5
Col1a2 7112.5
Itgav 7044.5
Col3a1 6825.5
Col1a1 6801.5
Fn1 6674.5
Ddr1 6633.5
Col5a1 6613.5
Itga2 6287.5
Itgb1 6225.5
Tgfb1 5780.5
Ddr2 5501.5
Col4a1 5401.5
Sdc1 5343.5
Col4a2 4843.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Sdc2 7146.5
Col1a2 7112.5
Itgav 7044.5
Col3a1 6825.5
Col1a1 6801.5
Fn1 6674.5
Ddr1 6633.5
Col5a1 6613.5
Itga2 6287.5
Itgb1 6225.5
Tgfb1 5780.5
Ddr2 5501.5
Col4a1 5401.5
Sdc1 5343.5
Col4a2 4843.5
Col4a6 4829.5
Itgb3 4215.5
Sdc3 4180.5
Itgb4 3931.5
Col11a2 3368.5
Sdc4 106.5
Col5a3 -2248.5
Itga6 -2635.5
Fgf2 -4844.5
Vtn -7215.5


CHONDROITIN SULFATE BIOSYNTHESIS
set CHONDROITIN SULFATE BIOSYNTHESIS
setSize 16
pANOVA 2.27e-05
s.dist 0.612
p.adjustANOVA 0.000372


Top enriched genes
Top 20 genes
GeneID Gene Rank
Bgn 7159.5
Dcn 7102.5
Cspg4 7055.5
Chpf2 6981.5
Vcan 6906.5
Chsy3 6642.5
Chst3 6625.5
Chsy1 6329.5
Csgalnact2 6170.5
Chpf 5883.5
Chst11 4798.5
Chst12 4764.5
Cspg5 2471.5
Chst7 -706.5
Csgalnact1 -2273.5
Chst15 -4215.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bgn 7159.5
Dcn 7102.5
Cspg4 7055.5
Chpf2 6981.5
Vcan 6906.5
Chsy3 6642.5
Chst3 6625.5
Chsy1 6329.5
Csgalnact2 6170.5
Chpf 5883.5
Chst11 4798.5
Chst12 4764.5
Cspg5 2471.5
Chst7 -706.5
Csgalnact1 -2273.5
Chst15 -4215.5


ELASTIC FIBRE FORMATION
set ELASTIC FIBRE FORMATION
setSize 36
pANOVA 2.34e-10
s.dist 0.61
p.adjustANOVA 8.42e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tgfb2 7422.5
Tgfb3 7271.5
Itga5 7129.5
Mfap5 7124.5
Ltbp2 7122.5
Loxl3 7086.5
Loxl2 7079.5
Ltbp3 7062.5
Itgav 7044.5
Bmp4 6926.5
Fbln5 6845.5
Itgb8 6689.5
Fn1 6674.5
Emilin1 6488.5
Fbln2 6428.5
Mfap4 6413.5
Lox 6388.5
Fbn1 6321.5
Ltbp4 6306.5
Itgb1 6225.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tgfb2 7422.5
Tgfb3 7271.5
Itga5 7129.5
Mfap5 7124.5
Ltbp2 7122.5
Loxl3 7086.5
Loxl2 7079.5
Ltbp3 7062.5
Itgav 7044.5
Bmp4 6926.5
Fbln5 6845.5
Itgb8 6689.5
Fn1 6674.5
Emilin1 6488.5
Fbln2 6428.5
Mfap4 6413.5
Lox 6388.5
Fbn1 6321.5
Ltbp4 6306.5
Itgb1 6225.5
Loxl1 6192.5
Loxl4 6099.5
Efemp2 5909.5
Tgfb1 5780.5
Ltbp1 5576.5
Itga8 5355.5
Fbn2 5227.5
Eln 4450.5
Itgb3 4215.5
Mfap2 3784.5
Bmp2 2246.5
Furin -2916.5
Itgb6 -6093.5
Emilin2 -6937.5
Bmp7 -7037.5
Vtn -7215.5


ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
set ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
setSize 42
pANOVA 1.45e-11
s.dist 0.602
p.adjustANOVA 6.89e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Col1a2 7112.5
Loxl3 7086.5
Loxl2 7079.5
Col15a1 7067.5
Col8a1 7060.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Pcolce 6881.5
Col9a2 6879.5
Col3a1 6825.5
Col1a1 6801.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Col1a2 7112.5
Loxl3 7086.5
Loxl2 7079.5
Col15a1 7067.5
Col8a1 7060.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Pcolce 6881.5
Col9a2 6879.5
Col3a1 6825.5
Col1a1 6801.5
Col5a1 6613.5
Bmp1 6565.5
Col6a3 6398.5
Lox 6388.5
Loxl1 6192.5
Loxl4 6099.5
Col18a1 5446.5
Col4a1 5401.5
Tll1 5176.5
Col4a2 4843.5
Col4a6 4829.5
Ctsl 4577.5
Mmp3 3878.5
Col11a2 3368.5
Ctss 168.5
Col5a3 -2248.5
Ctsb -2349.5
Tll2 -4614.5
Mmp13 -5581.5
Pxdn -5990.5
Mmp9 -6038.5
Col6a6 -6117.5


DEGRADATION OF CYSTEINE AND HOMOCYSTEINE
set DEGRADATION OF CYSTEINE AND HOMOCYSTEINE
setSize 10
pANOVA 0.00133
s.dist -0.586
p.adjustANOVA 0.013


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tst -6991.5
Ethe1 -6794.5
Txn2 -6722.5
Slc25a10 -6228.5
Suox -6053.5
Mpst -5400.5
Cth -4782.5
Ado -3365.5
Cdo1 -2351.5
Fmo1 2281.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tst -6991.5
Ethe1 -6794.5
Txn2 -6722.5
Slc25a10 -6228.5
Suox -6053.5
Mpst -5400.5
Cth -4782.5
Ado -3365.5
Cdo1 -2351.5
Fmo1 2281.5


COLLAGEN FORMATION
set COLLAGEN FORMATION
setSize 65
pANOVA 3.06e-16
s.dist 0.586
p.adjustANOVA 2.29e-14


Top enriched genes
Top 20 genes
GeneID Gene Rank
P3h2 7439.5
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col22a1 7259.5
Col4a4 7256.5
Col16a1 7242.5
Col1a2 7112.5
Loxl3 7086.5
Loxl2 7079.5
Col15a1 7067.5
Col8a1 7060.5
Pcolce2 7041.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
P3h2 7439.5
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col22a1 7259.5
Col4a4 7256.5
Col16a1 7242.5
Col1a2 7112.5
Loxl3 7086.5
Loxl2 7079.5
Col15a1 7067.5
Col8a1 7060.5
Pcolce2 7041.5
Col14a1 7029.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Pcolce 6881.5
Col9a2 6879.5
P3h3 6865.5
Adamts2 6841.5
P4ha1 6829.5
Col3a1 6825.5
Col1a1 6801.5
Col20a1 6720.5
Col5a1 6613.5
Bmp1 6565.5
Plod2 6408.5
Col6a3 6398.5
Lox 6388.5
Loxl1 6192.5
Loxl4 6099.5
Adamts14 5846.5
Col18a1 5446.5
Col4a1 5401.5
P4hb 5325.5
Plod3 5321.5
Col13a1 5244.5
Tll1 5176.5
Col26a1 5088.5
Col4a2 4843.5
Col4a6 4829.5
Ctsl 4577.5
Serpinh1 4119.5
Mmp3 3878.5
Col28a1 3652.5
Colgalt1 3585.5
Col11a2 3368.5
Plod1 2663.5
Col23a1 908.5
Ctss 168.5
Col25a1 -1726.5
Colgalt2 -1962.5
Col5a3 -2248.5
Ctsb -2349.5
P4ha2 -3947.5
Adamts3 -4018.5
Tll2 -4614.5
Mmp13 -5581.5
Pxdn -5990.5
Mmp9 -6038.5
Col6a6 -6117.5


MOLECULES ASSOCIATED WITH ELASTIC FIBRES
set MOLECULES ASSOCIATED WITH ELASTIC FIBRES
setSize 29
pANOVA 5.33e-08
s.dist 0.584
p.adjustANOVA 1.43e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tgfb2 7422.5
Tgfb3 7271.5
Mfap5 7124.5
Ltbp2 7122.5
Ltbp3 7062.5
Itgav 7044.5
Bmp4 6926.5
Fbln5 6845.5
Itgb8 6689.5
Fn1 6674.5
Emilin1 6488.5
Fbln2 6428.5
Mfap4 6413.5
Fbn1 6321.5
Ltbp4 6306.5
Itgb1 6225.5
Efemp2 5909.5
Tgfb1 5780.5
Ltbp1 5576.5
Itga8 5355.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tgfb2 7422.5
Tgfb3 7271.5
Mfap5 7124.5
Ltbp2 7122.5
Ltbp3 7062.5
Itgav 7044.5
Bmp4 6926.5
Fbln5 6845.5
Itgb8 6689.5
Fn1 6674.5
Emilin1 6488.5
Fbln2 6428.5
Mfap4 6413.5
Fbn1 6321.5
Ltbp4 6306.5
Itgb1 6225.5
Efemp2 5909.5
Tgfb1 5780.5
Ltbp1 5576.5
Itga8 5355.5
Fbn2 5227.5
Eln 4450.5
Itgb3 4215.5
Mfap2 3784.5
Bmp2 2246.5
Itgb6 -6093.5
Emilin2 -6937.5
Bmp7 -7037.5
Vtn -7215.5


DISSOLUTION OF FIBRIN CLOT
set DISSOLUTION OF FIBRIN CLOT
setSize 10
pANOVA 0.00156
s.dist 0.578
p.adjustANOVA 0.0148


Top enriched genes
Top 20 genes
GeneID Gene Rank
Serpinb6a 7328.5
Anxa2 7318.5
S100a10 7047.5
Serpine1 6577.5
Serpine2 6507.5
Plat 5116.5
Serpinb8 4787.5
Serpinf2 735.5
Plau -1442.5
Plaur -1742.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Serpinb6a 7328.5
Anxa2 7318.5
S100a10 7047.5
Serpine1 6577.5
Serpine2 6507.5
Plat 5116.5
Serpinb8 4787.5
Serpinf2 735.5
Plau -1442.5
Plaur -1742.5


THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION
set THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION
setSize 10
pANOVA 0.00178
s.dist 0.571
p.adjustANOVA 0.0165


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rbp4 7408.5
Rbp1 7244.5
Ttr 7134.5
Dhrs9 6827.5
Myo7a 6022.5
Rdh11 5782.5
Cyp4v3 2165.5
Rdh5 1622.5
Abca4 -87.5
Rdh10 -2420.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rbp4 7408.5
Rbp1 7244.5
Ttr 7134.5
Dhrs9 6827.5
Myo7a 6022.5
Rdh11 5782.5
Cyp4v3 2165.5
Rdh5 1622.5
Abca4 -87.5
Rdh10 -2420.5


PYRUVATE METABOLISM
set PYRUVATE METABOLISM
setSize 42
pANOVA 1.71e-10
s.dist -0.569
p.adjustANOVA 6.68e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ldhb -7702.5
Pdhx -7696.5
Fahd1 -7642.5
Dld -7624.5
Pdpr -7613.5
Me3 -7579.5
Dlat -7564.5
Gpt -7508.5
Vdac1 -7461.5
Pdha1 -7382.5
Pdp2 -7368.5
Pdhb -7319.5
Gstz1 -7264.5
Gid4 -7209.5
Pdk2 -7201.5
Me1 -7018.5
Pkm -6577.5
Pdk1 -6558.5
Pcx -6534.5
Ranbp9 -6411.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ldhb -7702.5
Pdhx -7696.5
Fahd1 -7642.5
Dld -7624.5
Pdpr -7613.5
Me3 -7579.5
Dlat -7564.5
Gpt -7508.5
Vdac1 -7461.5
Pdha1 -7382.5
Pdp2 -7368.5
Pdhb -7319.5
Gstz1 -7264.5
Gid4 -7209.5
Pdk2 -7201.5
Me1 -7018.5
Pkm -6577.5
Pdk1 -6558.5
Pcx -6534.5
Ranbp9 -6411.5
Glo1 -5785.5
Pgam5 -5698.5
Rmnd5a -5637.5
Sirt4 -5456.5
Gid8 -5117.5
Armc8 -4929.5
Ldha -4720.5
Pdp1 -4680.5
Mkln1 -4361.5
Nek1 -4082.5
Uba52 -3735.5
Ubc -2084.5
Maea -1825.5
Ldhal6b -1655.5
Ubb -1647.5
Hagh -1200.5
Rps27a -996.5
Wdr26 652.5
Pdk4 1859.5
Me2 4725.5
Rmnd5b 5434.5
Pdk3 7005.5


CARNITINE METABOLISM
set CARNITINE METABOLISM
setSize 14
pANOVA 0.000239
s.dist -0.567
p.adjustANOVA 0.0029


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cpt2 -7636.5
Slc25a20 -7590.5
Slc22a5 -7449.5
Acacb -7427.5
Prkaa2 -7248.5
Rxra -7138.5
Thrsp -5768.5
Cpt1b -5387.5
Ppard -4327.5
Mid1ip1 -3851.5
Cpt1a -3103.5
Prkag2 -2049.5
Acaca -251.5
Prkab2 6294.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cpt2 -7636.5
Slc25a20 -7590.5
Slc22a5 -7449.5
Acacb -7427.5
Prkaa2 -7248.5
Rxra -7138.5
Thrsp -5768.5
Cpt1b -5387.5
Ppard -4327.5
Mid1ip1 -3851.5
Cpt1a -3103.5
Prkag2 -2049.5
Acaca -251.5
Prkab2 6294.5


PEROXISOMAL PROTEIN IMPORT
set PEROXISOMAL PROTEIN IMPORT
setSize 61
pANOVA 2.03e-14
s.dist -0.566
p.adjustANOVA 1.3e-12


Top enriched genes
Top 20 genes
GeneID Gene Rank
Phyh -7748.5
Gnpat -7739.5
Gstk1 -7713.5
Acox1 -7669.5
Ephx2 -7668.5
Eci2 -7657.5
Crat -7634.5
Ech1 -7535.5
Acot1 -7501.5
Hsd17b4 -7458.5
Scp2 -7418.5
Dhrs4 -7386.5
Acot2 -7351.5
Amacr -7333.5
Lonp2 -7252.5
Nudt7 -7132.5
Mlycd -6985.5
Pex7 -6802.5
Ehhadh -6680.5
Pex2 -6674.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Phyh -7748.5
Gnpat -7739.5
Gstk1 -7713.5
Acox1 -7669.5
Ephx2 -7668.5
Eci2 -7657.5
Crat -7634.5
Ech1 -7535.5
Acot1 -7501.5
Hsd17b4 -7458.5
Scp2 -7418.5
Dhrs4 -7386.5
Acot2 -7351.5
Amacr -7333.5
Lonp2 -7252.5
Nudt7 -7132.5
Mlycd -6985.5
Pex7 -6802.5
Ehhadh -6680.5
Pex2 -6674.5
Acot3 -6542.5
Nudt19 -6316.5
Idh1 -6315.5
Pex10 -6303.5
Pecr -6207.5
Mpv17 -6066.5
Nos2 -6044.5
Ube2d1 -5930.5
Acot4 -5724.5
Pex13 -5560.5
Pex6 -5487.5
Zfand6 -5416.5
Pex1 -5296.5
Decr2 -5240.5
Ddo -5188.5
Hmgcl -5039.5
Ube2d2a -4957.5
Ide -4616.5
Uba52 -3735.5
Pex12 -3637.5
Acox3 -3569.5
Tysnd1 -3190.5
Usp9x -2880.5
Pex26 -2788.5
Crot -2783.5
Paox -2565.5
Pex14 -2411.5
Ubc -2084.5
Ubb -1647.5
Cat -1458.5
Rps27a -996.5
Hacl1 -725.5
Acot8 -597.5
Acaa1b -373.5
Dao -109.5
Slc27a2 531.5
Hao2 551.5
Acox2 1835.5
Pipox 2443.5
Pex5 3086.5
Ube2d3 3793.5


REGULATION OF PYRUVATE METABOLISM
set REGULATION OF PYRUVATE METABOLISM
setSize 32
pANOVA 5.38e-08
s.dist -0.555
p.adjustANOVA 1.43e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pdhx -7696.5
Dld -7624.5
Pdpr -7613.5
Dlat -7564.5
Pdha1 -7382.5
Pdp2 -7368.5
Pdhb -7319.5
Gstz1 -7264.5
Gid4 -7209.5
Pdk2 -7201.5
Me1 -7018.5
Pkm -6577.5
Pdk1 -6558.5
Ranbp9 -6411.5
Pgam5 -5698.5
Rmnd5a -5637.5
Sirt4 -5456.5
Gid8 -5117.5
Armc8 -4929.5
Ldha -4720.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdhx -7696.5
Dld -7624.5
Pdpr -7613.5
Dlat -7564.5
Pdha1 -7382.5
Pdp2 -7368.5
Pdhb -7319.5
Gstz1 -7264.5
Gid4 -7209.5
Pdk2 -7201.5
Me1 -7018.5
Pkm -6577.5
Pdk1 -6558.5
Ranbp9 -6411.5
Pgam5 -5698.5
Rmnd5a -5637.5
Sirt4 -5456.5
Gid8 -5117.5
Armc8 -4929.5
Ldha -4720.5
Pdp1 -4680.5
Mkln1 -4361.5
Nek1 -4082.5
Uba52 -3735.5
Ubc -2084.5
Maea -1825.5
Ubb -1647.5
Rps27a -996.5
Wdr26 652.5
Pdk4 1859.5
Rmnd5b 5434.5
Pdk3 7005.5


GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION
set GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION
setSize 14
pANOVA 0.000327
s.dist -0.555
p.adjustANOVA 0.00367


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dlst -7780.5
Dld -7624.5
Ogdh -7608.5
Aldh4a1 -7586.5
Got2 -6959.5
Grhpr -5791.5
Gcsh -5471.5
Mrps36 -5338.5
Ddo -5188.5
Gnmt -4732.5
Amt -2126.5
Dao -109.5
Gldc 2230.5
Hoga1 2483.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dlst -7780.5
Dld -7624.5
Ogdh -7608.5
Aldh4a1 -7586.5
Got2 -6959.5
Grhpr -5791.5
Gcsh -5471.5
Mrps36 -5338.5
Ddo -5188.5
Gnmt -4732.5
Amt -2126.5
Dao -109.5
Gldc 2230.5
Hoga1 2483.5


ENDOSOMAL VACUOLAR PATHWAY
set ENDOSOMAL VACUOLAR PATHWAY
setSize 10
pANOVA 0.0026
s.dist 0.55
p.adjustANOVA 0.0223


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2-T23 6309.5
H2-T22 5423.5
B2m 4814.5
Lnpep 4396.5
H2-K1 4150.5
H2-T10 3758.5
H2-Q7 3208.5
H2-Q6 3177.5
H2-Q4 2988.5
H2-M3 1899.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2-T23 6309.5
H2-T22 5423.5
B2m 4814.5
Lnpep 4396.5
H2-K1 4150.5
H2-T10 3758.5
H2-Q7 3208.5
H2-Q6 3177.5
H2-Q4 2988.5
H2-M3 1899.5


TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS
set TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS
setSize 11
pANOVA 0.00236
s.dist 0.529
p.adjustANOVA 0.0208


Top enriched genes
Top 20 genes
GeneID Gene Rank
Edar 7344.5
Tnfrsf11b 6905.5
Eda2r 6766.5
Eda 5191.5
Tnfrsf1a 4613.5
Tnfrsf1b 4409.5
Tnfrsf14 3697.5
Tnfsf13b 2508.5
Tnfrsf25 1160.5
Tnfrsf13b 523.5
Tnfsf13 -704.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edar 7344.5
Tnfrsf11b 6905.5
Eda2r 6766.5
Eda 5191.5
Tnfrsf1a 4613.5
Tnfrsf1b 4409.5
Tnfrsf14 3697.5
Tnfsf13b 2508.5
Tnfrsf25 1160.5
Tnfrsf13b 523.5
Tnfsf13 -704.5


CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
set CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
setSize 18
pANOVA 0.000129
s.dist -0.521
p.adjustANOVA 0.00176


Top enriched genes
Top 20 genes
GeneID Gene Rank
Abcd3 -7413.5
Pxmp4 -7393.5
Pex2 -6674.5
Pex19 -6586.5
Abcd1 -6415.5
Pex13 -5560.5
Slc25a17 -5210.5
Abcd2 -5044.5
Atad1 -4848.5
Pex11b -4334.5
Pex3 -3932.5
Pex12 -3637.5
Pex16 -3506.5
Fis1 -2871.5
Pex26 -2788.5
Pex14 -2411.5
Aldh3a2 -842.5
Acbd5 4863.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Abcd3 -7413.5
Pxmp4 -7393.5
Pex2 -6674.5
Pex19 -6586.5
Abcd1 -6415.5
Pex13 -5560.5
Slc25a17 -5210.5
Abcd2 -5044.5
Atad1 -4848.5
Pex11b -4334.5
Pex3 -3932.5
Pex12 -3637.5
Pex16 -3506.5
Fis1 -2871.5
Pex26 -2788.5
Pex14 -2411.5
Aldh3a2 -842.5
Acbd5 4863.5


COLLAGEN DEGRADATION
set COLLAGEN DEGRADATION
setSize 39
pANOVA 5.6e-08
s.dist 0.503
p.adjustANOVA 1.44e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Mmp2 7250.5
Ctsk 7186.5
Col1a2 7112.5
Col15a1 7067.5
Col8a1 7060.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Col3a1 6825.5
Col1a1 6801.5
Col5a1 6613.5
Col6a3 6398.5
Mmp14 5677.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col12a1 7358.5
Col8a2 7341.5
Col11a1 7324.5
Col4a3 7307.5
Col4a5 7299.5
Col5a2 7277.5
Col4a4 7256.5
Mmp2 7250.5
Ctsk 7186.5
Col1a2 7112.5
Col15a1 7067.5
Col8a1 7060.5
Col6a2 6990.5
Col7a1 6902.5
Col6a1 6887.5
Col3a1 6825.5
Col1a1 6801.5
Col5a1 6613.5
Col6a3 6398.5
Mmp14 5677.5
Col18a1 5446.5
Col4a1 5401.5
Col13a1 5244.5
Col26a1 5088.5
Col4a2 4843.5
Col4a6 4829.5
Mmp3 3878.5
Col11a2 3368.5
Mmp11 2100.5
Col25a1 -1726.5
Ctsd -1925.5
Col5a3 -2248.5
Ctsb -2349.5
Phykpl -2612.5
Furin -2916.5
Mmp13 -5581.5
Mmp9 -6038.5
Col6a6 -6117.5
Mmp15 -6496.5


CYTOPROTECTION BY HMOX1
set CYTOPROTECTION BY HMOX1
setSize 44
pANOVA 1.6e-08
s.dist -0.492
p.adjustANOVA 4.79e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cox7a1 -7777.5
Cox5a -7703.5
Ppara -7533.5
mt-Co1 -7341.5
Cycs -7336.5
Cox4i1 -7294.5
Ndufa4 -7281.5
Hdac3 -7244.5
Cox6c -7238.5
Cox5b -7225.5
Cox7b -7157.5
Rxra -7138.5
Cox7c -7135.5
Ncoa2 -6965.5
Ncoa1 -6960.5
Cox7a2l -6879.5
Cox6b1 -6861.5
Hmox2 -6797.5
Cox6a2 -6766.5
Cox7a2 -6681.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cox7a1 -7777.5
Cox5a -7703.5
Ppara -7533.5
mt-Co1 -7341.5
Cycs -7336.5
Cox4i1 -7294.5
Ndufa4 -7281.5
Hdac3 -7244.5
Cox6c -7238.5
Cox5b -7225.5
Cox7b -7157.5
Rxra -7138.5
Cox7c -7135.5
Ncoa2 -6965.5
Ncoa1 -6960.5
Cox7a2l -6879.5
Cox6b1 -6861.5
Hmox2 -6797.5
Cox6a2 -6766.5
Cox7a2 -6681.5
Med1 -6035.5
Carm1 -5966.5
Cox6b2 -5595.5
Tgs1 -5364.5
Cox4i2 -5203.5
Blvra -4159.5
Cox6a1 -3949.5
Blvrb -3909.5
Tbl1x -3301.5
Sin3a -2809.5
Tbl1xr1 -2096.5
Hba-a1 -1635.5
Hbb-bt -1528.5
Hbb-bs -1220.5
Cox8a -1185.5
Smarcd3 -1182.5
Sin3b -242.5
Hmox1 544.5
Alb 1313.5
Helz2 2251.5
Ncor2 4366.5
Chd9 5171.5
H13 5335.5
Abcc1 7306.5


SULFUR AMINO ACID METABOLISM
set SULFUR AMINO ACID METABOLISM
setSize 19
pANOVA 0.000234
s.dist -0.488
p.adjustANOVA 0.00288


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adi1 -7704.5
Mtr -7339.5
Tst -6991.5
Ethe1 -6794.5
Txn2 -6722.5
Slc25a10 -6228.5
Suox -6053.5
Mtap -5773.5
Mtrr -5635.5
Mpst -5400.5
Cth -4782.5
Mri1 -4210.5
Ado -3365.5
Cdo1 -2351.5
Enoph1 -262.5
Cbs 496.5
Mat1a 571.5
Fmo1 2281.5
Ahcy 2387.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adi1 -7704.5
Mtr -7339.5
Tst -6991.5
Ethe1 -6794.5
Txn2 -6722.5
Slc25a10 -6228.5
Suox -6053.5
Mtap -5773.5
Mtrr -5635.5
Mpst -5400.5
Cth -4782.5
Mri1 -4210.5
Ado -3365.5
Cdo1 -2351.5
Enoph1 -262.5
Cbs 496.5
Mat1a 571.5
Fmo1 2281.5
Ahcy 2387.5


METABOLISM OF PORPHYRINS
set METABOLISM OF PORPHYRINS
setSize 21
pANOVA 0.000129
s.dist -0.483
p.adjustANOVA 0.00176


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fech -7592.5
Cox10 -7440.5
Alad -7277.5
Cox15 -7202.5
Alas1 -6948.5
Hmox2 -6797.5
Hmbs -6783.5
Uros -6771.5
Urod -6640.5
Cpox -6353.5
Slco2b1 -5569.5
Gsta1 -5259.5
Blvra -4159.5
Blvrb -3909.5
Alas2 -1531.5
Ppox -1183.5
Gsta3 156.5
Hmox1 544.5
Abcc2 1253.5
Alb 1313.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fech -7592.5
Cox10 -7440.5
Alad -7277.5
Cox15 -7202.5
Alas1 -6948.5
Hmox2 -6797.5
Hmbs -6783.5
Uros -6771.5
Urod -6640.5
Cpox -6353.5
Slco2b1 -5569.5
Gsta1 -5259.5
Blvra -4159.5
Blvrb -3909.5
Alas2 -1531.5
Ppox -1183.5
Gsta3 156.5
Hmox1 544.5
Abcc2 1253.5
Alb 1313.5
Abcc1 7306.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] kableExtra_1.4.0 pkgload_1.4.0    GGally_2.2.1     ggplot2_3.5.1   
##  [5] reshape2_1.4.4   beeswarm_0.4.0   gplots_3.2.0     gtools_3.9.5    
##  [9] tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5  mitch_1.17.4    
## 
## loaded via a namespace (and not attached):
##  [1] sass_0.4.9         utf8_1.2.4         generics_0.1.3     tidyr_1.3.1       
##  [5] bitops_1.0-9       xml2_1.3.6         KernSmooth_2.23-24 stringi_1.8.4     
##  [9] caTools_1.18.3     digest_0.6.37      magrittr_2.0.3     evaluate_1.0.1    
## [13] grid_4.4.1         RColorBrewer_1.1-3 fastmap_1.2.0      plyr_1.8.9        
## [17] jsonlite_1.8.9     gridExtra_2.3      promises_1.3.0     purrr_1.0.2       
## [21] fansi_1.0.6        viridisLite_0.4.2  scales_1.3.0       jquerylib_0.1.4   
## [25] cli_3.6.3          shiny_1.9.1        rlang_1.1.4        munsell_0.5.1     
## [29] withr_3.0.1        cachem_1.1.0       yaml_2.3.10        parallel_4.4.1    
## [33] tools_4.4.1        colorspace_2.1-1   httpuv_1.6.15      ggstats_0.7.0     
## [37] vctrs_0.6.5        R6_2.5.1           mime_0.12          lifecycle_1.0.4   
## [41] stringr_1.5.1      htmlwidgets_1.6.4  MASS_7.3-61        pkgconfig_2.0.3   
## [45] pillar_1.9.0       bslib_0.8.0        later_1.3.2        gtable_0.3.5      
## [49] glue_1.8.0         Rcpp_1.0.13        systemfonts_1.1.0  highr_0.11        
## [53] xfun_0.48          tidyselect_1.2.1   rstudioapi_0.17.1  knitr_1.48        
## [57] xtable_1.8-4       htmltools_0.5.8.1  rmarkdown_2.28     svglite_2.1.3     
## [61] compiler_4.4.1

END of report