date generated: 2025-01-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
stat
5_8S_rRNA 0.5180755
A4GALT -0.4952824
AAAS -1.7533504
AACS 0.8714301
AADAC -0.4594811
AADAT -0.0656957

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 5133
num_genes_in_profile 14582
duplicated_genes_present 0
num_profile_genes_in_sets 9238
num_profile_genes_not_in_sets 5344

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 5133
num_genesets_excluded 3357
num_genesets_included 1776

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
GO:0140662 ATP-dependent protein folding chaperone 23 2.72e-07 -0.619 0.000242
GO:0051315 attachment of mitotic spindle microtubules to kinetochore 10 8.47e-04 -0.609 0.032800
GO:0090201 negative regulation of release of cytochrome c from mitochondria 11 1.74e-03 -0.545 0.051500
GO:0001965 G-protein alpha-subunit binding 10 4.22e-03 0.523 0.085000
GO:0000400 four-way junction DNA binding 14 1.00e-03 -0.508 0.035700
GO:0042026 protein refolding 12 2.34e-03 -0.507 0.059200
GO:0032212 positive regulation of telomere maintenance via telomerase 17 3.51e-04 -0.501 0.022800
GO:0007339 binding of sperm to zona pellucida 11 4.71e-03 -0.492 0.090600
GO:0003678 DNA helicase activity 20 1.48e-04 -0.490 0.021000
GO:0001782 B cell homeostasis 12 5.00e-03 0.468 0.094000
GO:0007017 microtubule-based process 11 7.80e-03 -0.463 0.128000
GO:0071233 cellular response to L-leucine 10 1.17e-02 0.461 0.170000
GO:0006913 nucleocytoplasmic transport 18 7.28e-04 -0.460 0.030300
GO:0003007 heart morphogenesis 16 1.60e-03 0.456 0.048200
GO:0030282 bone mineralization 24 1.26e-04 0.452 0.020300
GO:1990166 protein localization to site of double-strand break 10 1.46e-02 -0.446 0.191000
GO:0072542 protein phosphatase activator activity 10 1.54e-02 -0.442 0.198000
GO:0017116 single-stranded DNA helicase activity 16 2.62e-03 -0.435 0.061500
GO:0000793 condensed chromosome 13 6.91e-03 -0.433 0.118000
GO:0030863 cortical cytoskeleton 11 1.30e-02 -0.433 0.181000
GO:0008320 protein transmembrane transporter activity 11 1.34e-02 -0.431 0.184000
GO:0071333 cellular response to glucose stimulus 13 7.20e-03 0.430 0.122000
GO:0140658 ATP-dependent chromatin remodeler activity 11 1.41e-02 0.427 0.189000
GO:0007076 mitotic chromosome condensation 10 1.99e-02 -0.425 0.225000
GO:0080008 Cul4-RING E3 ubiquitin ligase complex 13 8.35e-03 -0.423 0.135000
GO:0051085 chaperone cofactor-dependent protein refolding 23 4.63e-04 -0.422 0.022800
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 11 1.55e-02 0.422 0.198000
GO:0001671 ATPase activator activity 18 1.98e-03 -0.421 0.053800
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 11 1.60e-02 0.419 0.202000
GO:0042407 cristae formation 11 1.68e-02 -0.416 0.206000
GO:0007129 homologous chromosome pairing at meiosis 13 9.42e-03 -0.416 0.148000
GO:0030500 regulation of bone mineralization 12 1.26e-02 0.416 0.179000
GO:0005581 collagen trimer 21 9.99e-04 0.415 0.035700
GO:0140664 ATP-dependent DNA damage sensor activity 14 7.34e-03 -0.414 0.123000
GO:0007611 learning or memory 15 5.94e-03 0.410 0.104000
GO:0006270 DNA replication initiation 19 2.00e-03 -0.410 0.053800
GO:0004402 histone acetyltransferase activity 11 1.95e-02 0.407 0.224000
GO:0000159 protein phosphatase type 2A complex 12 1.50e-02 -0.406 0.194000
GO:0006310 DNA recombination 23 8.59e-04 -0.402 0.032800
GO:0034605 cellular response to heat 16 5.63e-03 -0.400 0.102000
GO:0003899 DNA-directed 5’-3’ RNA polymerase activity 10 3.01e-02 -0.396 0.292000
GO:0001818 negative regulation of cytokine production 11 2.35e-02 -0.394 0.251000
GO:0005852 eukaryotic translation initiation factor 3 complex 10 3.30e-02 -0.389 0.306000
GO:0045505 dynein intermediate chain binding 18 4.26e-03 0.389 0.085000
GO:0006413 translational initiation 30 2.33e-04 -0.388 0.021000
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 34 9.29e-05 0.387 0.016900
GO:0006268 DNA unwinding involved in DNA replication 14 1.22e-02 -0.387 0.176000
GO:0007004 telomere maintenance via telomerase 11 2.67e-02 -0.386 0.270000
GO:0140823 histone H2BS36 kinase activity 31 2.00e-04 0.386 0.021000
GO:0035994 response to muscle stretch 10 3.50e-02 0.385 0.312000


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
GO:0140662 ATP-dependent protein folding chaperone 23 2.72e-07 -6.19e-01 0.000242
GO:0051315 attachment of mitotic spindle microtubules to kinetochore 10 8.47e-04 -6.09e-01 0.032800
GO:0090201 negative regulation of release of cytochrome c from mitochondria 11 1.74e-03 -5.45e-01 0.051500
GO:0001965 G-protein alpha-subunit binding 10 4.22e-03 5.23e-01 0.085000
GO:0000400 four-way junction DNA binding 14 1.00e-03 -5.08e-01 0.035700
GO:0042026 protein refolding 12 2.34e-03 -5.07e-01 0.059200
GO:0032212 positive regulation of telomere maintenance via telomerase 17 3.51e-04 -5.01e-01 0.022800
GO:0007339 binding of sperm to zona pellucida 11 4.71e-03 -4.92e-01 0.090600
GO:0003678 DNA helicase activity 20 1.48e-04 -4.90e-01 0.021000
GO:0001782 B cell homeostasis 12 5.00e-03 4.68e-01 0.094000
GO:0007017 microtubule-based process 11 7.80e-03 -4.63e-01 0.128000
GO:0071233 cellular response to L-leucine 10 1.17e-02 4.61e-01 0.170000
GO:0006913 nucleocytoplasmic transport 18 7.28e-04 -4.60e-01 0.030300
GO:0003007 heart morphogenesis 16 1.60e-03 4.56e-01 0.048200
GO:0030282 bone mineralization 24 1.26e-04 4.52e-01 0.020300
GO:1990166 protein localization to site of double-strand break 10 1.46e-02 -4.46e-01 0.191000
GO:0072542 protein phosphatase activator activity 10 1.54e-02 -4.42e-01 0.198000
GO:0017116 single-stranded DNA helicase activity 16 2.62e-03 -4.35e-01 0.061500
GO:0000793 condensed chromosome 13 6.91e-03 -4.33e-01 0.118000
GO:0030863 cortical cytoskeleton 11 1.30e-02 -4.33e-01 0.181000
GO:0008320 protein transmembrane transporter activity 11 1.34e-02 -4.31e-01 0.184000
GO:0071333 cellular response to glucose stimulus 13 7.20e-03 4.30e-01 0.122000
GO:0140658 ATP-dependent chromatin remodeler activity 11 1.41e-02 4.27e-01 0.189000
GO:0007076 mitotic chromosome condensation 10 1.99e-02 -4.25e-01 0.225000
GO:0080008 Cul4-RING E3 ubiquitin ligase complex 13 8.35e-03 -4.23e-01 0.135000
GO:0051085 chaperone cofactor-dependent protein refolding 23 4.63e-04 -4.22e-01 0.022800
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 11 1.55e-02 4.22e-01 0.198000
GO:0001671 ATPase activator activity 18 1.98e-03 -4.21e-01 0.053800
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 11 1.60e-02 4.19e-01 0.202000
GO:0042407 cristae formation 11 1.68e-02 -4.16e-01 0.206000
GO:0007129 homologous chromosome pairing at meiosis 13 9.42e-03 -4.16e-01 0.148000
GO:0030500 regulation of bone mineralization 12 1.26e-02 4.16e-01 0.179000
GO:0005581 collagen trimer 21 9.99e-04 4.15e-01 0.035700
GO:0140664 ATP-dependent DNA damage sensor activity 14 7.34e-03 -4.14e-01 0.123000
GO:0007611 learning or memory 15 5.94e-03 4.10e-01 0.104000
GO:0006270 DNA replication initiation 19 2.00e-03 -4.10e-01 0.053800
GO:0004402 histone acetyltransferase activity 11 1.95e-02 4.07e-01 0.224000
GO:0000159 protein phosphatase type 2A complex 12 1.50e-02 -4.06e-01 0.194000
GO:0006310 DNA recombination 23 8.59e-04 -4.02e-01 0.032800
GO:0034605 cellular response to heat 16 5.63e-03 -4.00e-01 0.102000
GO:0003899 DNA-directed 5’-3’ RNA polymerase activity 10 3.01e-02 -3.96e-01 0.292000
GO:0001818 negative regulation of cytokine production 11 2.35e-02 -3.94e-01 0.251000
GO:0005852 eukaryotic translation initiation factor 3 complex 10 3.30e-02 -3.89e-01 0.306000
GO:0045505 dynein intermediate chain binding 18 4.26e-03 3.89e-01 0.085000
GO:0006413 translational initiation 30 2.33e-04 -3.88e-01 0.021000
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 34 9.29e-05 3.87e-01 0.016900
GO:0006268 DNA unwinding involved in DNA replication 14 1.22e-02 -3.87e-01 0.176000
GO:0007004 telomere maintenance via telomerase 11 2.67e-02 -3.86e-01 0.270000
GO:0140823 histone H2BS36 kinase activity 31 2.00e-04 3.86e-01 0.021000
GO:0035994 response to muscle stretch 10 3.50e-02 3.85e-01 0.312000
GO:0004711 ribosomal protein S6 kinase activity 32 1.63e-04 3.85e-01 0.021000
GO:0000380 alternative mRNA splicing, via spliceosome 16 7.68e-03 -3.85e-01 0.128000
GO:1990244 histone H2AT120 kinase activity 31 2.29e-04 3.82e-01 0.021000
GO:0140584 chromatin extrusion motor activity 23 1.59e-03 -3.80e-01 0.048200
GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 23 1.59e-03 -3.80e-01 0.048200
GO:0140849 ATP-dependent H2AZ histone chaperone activity 23 1.59e-03 -3.80e-01 0.048200
GO:0003689 DNA clamp loader activity 32 2.29e-04 -3.76e-01 0.021000
GO:0004679 AMP-activated protein kinase activity 32 2.36e-04 3.76e-01 0.021000
GO:0032007 negative regulation of TOR signaling 19 4.74e-03 3.74e-01 0.090600
GO:0097602 cullin family protein binding 16 9.84e-03 -3.73e-01 0.153000
GO:1990518 single-stranded 3’-5’ DNA helicase activity 11 3.27e-02 -3.72e-01 0.306000
GO:0030199 collagen fibril organization 30 4.41e-04 3.71e-01 0.022800
GO:0035402 histone H3T11 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0044022 histone H3S28 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0044023 histone H4S1 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0044024 histone H2AS1 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0044025 histone H2BS14 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0072371 histone H2AS121 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0140855 histone H3S57 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0140857 histone H3T45 kinase activity 30 4.52e-04 3.70e-01 0.022800
GO:0000176 nuclear exosome (RNase complex) 12 2.74e-02 -3.68e-01 0.276000
GO:0007094 mitotic spindle assembly checkpoint signaling 19 5.69e-03 -3.66e-01 0.102000
GO:0009653 anatomical structure morphogenesis 21 3.67e-03 3.66e-01 0.077500
GO:0007052 mitotic spindle organization 34 2.23e-04 -3.66e-01 0.021000
GO:0061775 cohesin loader activity 24 1.93e-03 -3.66e-01 0.053800
GO:0035979 histone H2AXS139 kinase activity 32 3.56e-04 3.65e-01 0.022800
GO:0006298 mismatch repair 16 1.17e-02 -3.64e-01 0.170000
GO:0004683 calcium/calmodulin-dependent protein kinase activity 11 3.72e-02 3.63e-01 0.325000
GO:0061749 forked DNA-dependent helicase activity 10 4.74e-02 -3.62e-01 0.356000
GO:0051082 unfolded protein binding 57 2.46e-06 -3.61e-01 0.000875
GO:0009755 hormone-mediated signaling pathway 10 4.84e-02 3.61e-01 0.356000
GO:0022627 cytosolic small ribosomal subunit 25 1.85e-03 3.60e-01 0.053100
GO:0051959 dynein light intermediate chain binding 17 1.04e-02 3.59e-01 0.159000
GO:0022625 cytosolic large ribosomal subunit 40 9.52e-05 3.57e-01 0.016900
GO:0035855 megakaryocyte development 10 5.09e-02 -3.57e-01 0.362000
GO:0002181 cytoplasmic translation 27 1.35e-03 3.56e-01 0.044400
GO:0140588 chromatin looping 27 1.38e-03 -3.56e-01 0.044600
GO:0055013 cardiac muscle cell development 11 4.23e-02 3.54e-01 0.344000
GO:0030097 hemopoiesis 25 2.21e-03 3.54e-01 0.057800
GO:0070182 DNA polymerase binding 13 2.76e-02 -3.53e-01 0.277000
GO:0001756 somitogenesis 24 2.83e-03 3.52e-01 0.064400
GO:0045821 positive regulation of glycolytic process 10 5.46e-02 3.51e-01 0.368000
GO:0004677 DNA-dependent protein kinase activity 31 7.35e-04 3.50e-01 0.030300
GO:0070034 telomerase RNA binding 12 3.60e-02 -3.50e-01 0.319000
GO:0003824 catalytic activity 11 4.50e-02 -3.49e-01 0.352000
GO:0045292 mRNA cis splicing, via spliceosome 13 2.94e-02 -3.49e-01 0.291000
GO:0017147 Wnt-protein binding 18 1.06e-02 3.48e-01 0.161000
GO:0005201 extracellular matrix structural constituent 13 3.02e-02 3.47e-01 0.292000
GO:0035403 histone H3T6 kinase activity 32 6.86e-04 3.47e-01 0.030300
GO:0070382 exocytic vesicle 10 5.78e-02 -3.46e-01 0.378000
GO:0003180 aortic valve morphogenesis 11 4.68e-02 3.46e-01 0.356000
GO:0004676 3-phosphoinositide-dependent protein kinase activity 31 8.68e-04 3.46e-01 0.032800
GO:0043425 bHLH transcription factor binding 10 6.02e-02 3.43e-01 0.384000
GO:0006935 chemotaxis 14 2.62e-02 3.43e-01 0.269000
GO:0000086 G2/M transition of mitotic cell cycle 25 3.03e-03 -3.43e-01 0.066300
GO:0071168 protein localization to chromatin 17 1.46e-02 -3.42e-01 0.191000
GO:0045214 sarcomere organization 12 4.05e-02 -3.42e-01 0.335000
GO:0007338 single fertilization 19 1.02e-02 3.41e-01 0.157000
GO:0035371 microtubule plus-end 12 4.16e-02 -3.40e-01 0.340000
GO:0072518 Rho-dependent protein serine/threonine kinase activity 32 8.93e-04 3.39e-01 0.033000
GO:0007492 endoderm development 11 5.25e-02 3.38e-01 0.366000
GO:0051233 spindle midzone 17 1.62e-02 -3.37e-01 0.202000
GO:0001732 formation of cytoplasmic translation initiation complex 12 4.37e-02 -3.36e-01 0.351000
GO:0006352 DNA-templated transcription initiation 11 5.41e-02 -3.35e-01 0.368000
GO:0035175 histone H3S10 kinase activity 31 1.23e-03 3.35e-01 0.042100
GO:0072354 histone H3T3 kinase activity 31 1.23e-03 3.35e-01 0.042100
GO:0008154 actin polymerization or depolymerization 12 4.47e-02 -3.35e-01 0.352000
GO:0005828 kinetochore microtubule 10 6.69e-02 -3.35e-01 0.398000
GO:0071782 endoplasmic reticulum tubular network 12 4.50e-02 -3.34e-01 0.352000
GO:0034450 ubiquitin-ubiquitin ligase activity 12 4.55e-02 3.34e-01 0.353000
GO:0002230 positive regulation of defense response to virus by host 11 5.70e-02 -3.31e-01 0.378000
GO:0005179 hormone activity 12 4.74e-02 3.31e-01 0.356000
GO:0060348 bone development 28 2.64e-03 3.28e-01 0.061500
GO:0015030 Cajal body 26 3.77e-03 -3.28e-01 0.077900
GO:0005009 insulin receptor activity 15 2.87e-02 3.26e-01 0.287000
GO:0033290 eukaryotic 48S preinitiation complex 13 4.25e-02 -3.25e-01 0.344000
GO:0051018 protein kinase A binding 12 5.16e-02 3.25e-01 0.363000
GO:0032731 positive regulation of interleukin-1 beta production 11 6.28e-02 3.24e-01 0.390000
GO:0045765 regulation of angiogenesis 11 6.29e-02 -3.24e-01 0.390000
GO:0008286 insulin receptor signaling pathway 50 7.85e-05 3.23e-01 0.016900
GO:0036121 double-stranded DNA helicase activity 11 6.41e-02 -3.22e-01 0.390000
GO:1902774 late endosome to lysosome transport 10 7.81e-02 -3.22e-01 0.422000
GO:0047496 vesicle transport along microtubule 11 6.55e-02 3.21e-01 0.395000
GO:0036342 post-anal tail morphogenesis 10 7.93e-02 -3.20e-01 0.424000
GO:0006457 protein folding 81 7.61e-07 -3.18e-01 0.000450
GO:0007059 chromosome segregation 41 4.53e-04 -3.17e-01 0.022800
GO:0000460 maturation of 5.8S rRNA 11 6.96e-02 -3.16e-01 0.403000
GO:0010824 regulation of centrosome duplication 15 3.44e-02 -3.15e-01 0.309000
GO:1902358 sulfate transmembrane transport 10 8.80e-02 3.12e-01 0.445000
GO:0042474 middle ear morphogenesis 10 8.83e-02 3.11e-01 0.445000
GO:0032433 filopodium tip 10 8.89e-02 -3.11e-01 0.446000
GO:0051287 NAD binding 19 1.92e-02 -3.10e-01 0.224000
GO:0005158 insulin receptor binding 13 5.29e-02 3.10e-01 0.366000
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 16 3.18e-02 3.10e-01 0.299000
GO:0038202 TORC1 signaling 12 6.34e-02 3.10e-01 0.390000
GO:0008047 enzyme activator activity 15 3.84e-02 3.09e-01 0.325000
GO:0048009 insulin-like growth factor receptor signaling pathway 32 2.67e-03 3.07e-01 0.061500
GO:0048872 homeostasis of number of cells 14 4.93e-02 3.03e-01 0.356000
GO:0010839 negative regulation of keratinocyte proliferation 14 4.99e-02 -3.03e-01 0.357000
GO:0048787 presynaptic active zone membrane 10 9.78e-02 -3.02e-01 0.466000
GO:0032508 DNA duplex unwinding 44 5.34e-04 -3.02e-01 0.024900
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 11 8.39e-02 -3.01e-01 0.436000
GO:0051382 kinetochore assembly 11 8.44e-02 -3.01e-01 0.437000
GO:0050808 synapse organization 16 3.90e-02 2.98e-01 0.327000
GO:0019888 protein phosphatase regulator activity 16 3.98e-02 -2.97e-01 0.332000
GO:2000300 regulation of synaptic vesicle exocytosis 19 2.54e-02 2.96e-01 0.262000
GO:0001676 long-chain fatty acid metabolic process 11 8.94e-02 -2.96e-01 0.446000
GO:0042162 telomeric DNA binding 20 2.21e-02 -2.96e-01 0.242000
GO:0002224 toll-like receptor signaling pathway 15 4.80e-02 2.95e-01 0.356000
GO:0001662 behavioral fear response 12 7.75e-02 -2.94e-01 0.421000
GO:0050768 negative regulation of neurogenesis 10 1.08e-01 2.94e-01 0.488000
GO:0005657 replication fork 20 2.31e-02 -2.94e-01 0.248000
GO:0030522 intracellular receptor signaling pathway 18 3.11e-02 2.94e-01 0.294000
GO:0017022 myosin binding 11 9.35e-02 2.92e-01 0.454000
GO:0001736 establishment of planar polarity 11 9.52e-02 -2.91e-01 0.458000
GO:0005019 platelet-derived growth factor beta-receptor activity 14 6.02e-02 2.90e-01 0.384000
GO:0042645 mitochondrial nucleoid 37 2.29e-03 -2.90e-01 0.058900
GO:0015026 coreceptor activity 13 7.04e-02 2.90e-01 0.405000
GO:1902894 negative regulation of miRNA transcription 12 8.24e-02 2.90e-01 0.433000
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 13 7.12e-02 -2.89e-01 0.405000
GO:0070063 RNA polymerase binding 12 8.32e-02 2.89e-01 0.434000
GO:0005010 insulin-like growth factor receptor activity 14 6.16e-02 2.89e-01 0.388000
GO:0061462 protein localization to lysosome 10 1.14e-01 2.88e-01 0.501000
GO:0035249 synaptic transmission, glutamatergic 17 4.09e-02 2.86e-01 0.337000
GO:0005518 collagen binding 34 3.97e-03 2.86e-01 0.081000
GO:0007612 learning 13 7.50e-02 2.85e-01 0.415000
GO:0030946 protein tyrosine phosphatase activity, metal-dependent 15 5.76e-02 2.83e-01 0.378000
GO:0140793 histone H2AXY142 phosphatase activity 15 5.76e-02 2.83e-01 0.378000
GO:0005044 scavenger receptor activity 10 1.22e-01 2.82e-01 0.515000
GO:0070064 proline-rich region binding 10 1.23e-01 2.82e-01 0.516000
GO:0030970 retrograde protein transport, ER to cytosol 12 9.10e-02 -2.82e-01 0.450000
GO:0045499 chemorepellent activity 20 2.97e-02 2.81e-01 0.292000
GO:0003684 damaged DNA binding 34 4.71e-03 -2.80e-01 0.090600
GO:0003688 DNA replication origin binding 12 9.32e-02 -2.80e-01 0.454000
GO:0006465 signal peptide processing 10 1.25e-01 -2.80e-01 0.522000
GO:0035145 exon-exon junction complex 10 1.25e-01 -2.80e-01 0.522000
GO:1904019 epithelial cell apoptotic process 13 8.18e-02 2.79e-01 0.431000
GO:0006337 nucleosome disassembly 10 1.29e-01 -2.77e-01 0.525000
GO:0016853 isomerase activity 19 3.73e-02 -2.76e-01 0.325000
GO:0009378 four-way junction helicase activity 13 8.61e-02 -2.75e-01 0.440000
GO:0006884 cell volume homeostasis 13 8.62e-02 2.75e-01 0.440000
GO:0015908 fatty acid transport 11 1.15e-01 -2.75e-01 0.501000
GO:0038109 Kit signaling pathway 15 6.56e-02 2.75e-01 0.395000
GO:0006099 tricarboxylic acid cycle 19 3.85e-02 -2.74e-01 0.325000
GO:0030515 snoRNA binding 14 7.57e-02 -2.74e-01 0.415000
GO:0101031 protein folding chaperone complex 18 4.48e-02 -2.73e-01 0.352000
GO:0000278 mitotic cell cycle 54 5.19e-04 -2.73e-01 0.024900
GO:0004867 serine-type endopeptidase inhibitor activity 23 2.39e-02 2.72e-01 0.255000
GO:0060382 regulation of DNA strand elongation 10 1.36e-01 -2.72e-01 0.530000
GO:0046875 ephrin receptor binding 17 5.31e-02 -2.71e-01 0.366000
GO:0005774 vacuolar membrane 10 1.38e-01 -2.71e-01 0.530000
GO:0071407 cellular response to organic cyclic compound 11 1.20e-01 2.71e-01 0.513000
GO:0031468 nuclear membrane reassembly 11 1.22e-01 -2.70e-01 0.515000
GO:0001968 fibronectin binding 10 1.40e-01 -2.69e-01 0.530000
GO:0055074 calcium ion homeostasis 18 4.79e-02 2.69e-01 0.356000
GO:0097225 sperm midpiece 15 7.12e-02 -2.69e-01 0.405000
GO:0016485 protein processing 40 3.39e-03 2.68e-01 0.073400
GO:0005771 multivesicular body 21 3.42e-02 -2.67e-01 0.309000
GO:0071711 basement membrane organization 11 1.26e-01 2.67e-01 0.522000
GO:0051028 mRNA transport 27 1.66e-02 -2.66e-01 0.204000
GO:0045444 fat cell differentiation 43 2.52e-03 2.66e-01 0.060400
GO:0051721 protein phosphatase 2A binding 14 8.47e-02 -2.66e-01 0.437000
GO:0001837 epithelial to mesenchymal transition 17 5.77e-02 2.66e-01 0.378000
GO:0046677 response to antibiotic 13 9.69e-02 -2.66e-01 0.464000
GO:0042813 Wnt receptor activity 13 9.71e-02 2.66e-01 0.464000
GO:0048018 receptor ligand activity 19 4.52e-02 2.65e-01 0.352000
GO:0048813 dendrite morphogenesis 21 3.56e-02 2.65e-01 0.316000
GO:1990498 mitotic spindle microtubule 10 1.47e-01 -2.65e-01 0.547000
GO:0003697 single-stranded DNA binding 67 1.80e-04 -2.65e-01 0.021000
GO:0005721 pericentric heterochromatin 18 5.35e-02 -2.63e-01 0.366000
GO:0001568 blood vessel development 20 4.27e-02 2.62e-01 0.345000
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway 15 7.96e-02 2.61e-01 0.424000
GO:0090443 FAR/SIN/STRIPAK complex 12 1.17e-01 -2.61e-01 0.508000
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 19 4.94e-02 2.60e-01 0.356000
GO:0030658 transport vesicle membrane 14 9.18e-02 2.60e-01 0.451000
GO:0048870 cell motility 12 1.19e-01 -2.60e-01 0.510000
GO:0016740 transferase activity 23 3.10e-02 -2.60e-01 0.294000
GO:0009566 fertilization 13 1.06e-01 -2.59e-01 0.484000
GO:0070131 positive regulation of mitochondrial translation 10 1.56e-01 2.59e-01 0.571000
GO:0001503 ossification 26 2.24e-02 2.59e-01 0.243000
GO:0046326 positive regulation of D-glucose import 16 7.33e-02 2.59e-01 0.411000
GO:0044458 motile cilium assembly 12 1.21e-01 -2.59e-01 0.514000
GO:0017134 fibroblast growth factor binding 11 1.38e-01 2.59e-01 0.530000
GO:0007608 sensory perception of smell 12 1.21e-01 2.58e-01 0.514000
GO:0032760 positive regulation of tumor necrosis factor production 32 1.16e-02 2.58e-01 0.170000
GO:0022626 cytosolic ribosome 13 1.08e-01 -2.58e-01 0.488000
GO:0042130 negative regulation of T cell proliferation 12 1.23e-01 2.57e-01 0.517000
GO:0005021 vascular endothelial growth factor receptor activity 16 7.55e-02 2.57e-01 0.415000
GO:0001654 eye development 17 6.71e-02 2.57e-01 0.398000
GO:0003341 cilium movement 10 1.61e-01 2.56e-01 0.580000
GO:0004860 protein kinase inhibitor activity 18 6.07e-02 -2.55e-01 0.384000
GO:0071230 cellular response to amino acid stimulus 29 1.73e-02 2.55e-01 0.208000
GO:0010608 post-transcriptional regulation of gene expression 11 1.43e-01 -2.55e-01 0.536000
GO:0043010 camera-type eye development 22 3.86e-02 2.55e-01 0.325000
GO:0005006 epidermal growth factor receptor activity 15 8.82e-02 2.54e-01 0.445000
GO:0000723 telomere maintenance 29 1.81e-02 -2.54e-01 0.216000
GO:0043923 positive regulation by host of viral transcription 12 1.29e-01 -2.53e-01 0.525000
GO:0007162 negative regulation of cell adhesion 17 7.13e-02 2.53e-01 0.405000
GO:0061952 midbody abscission 14 1.02e-01 -2.53e-01 0.476000
GO:0035925 mRNA 3’-UTR AU-rich region binding 13 1.15e-01 -2.52e-01 0.501000
GO:0120163 negative regulation of cold-induced thermogenesis 21 4.58e-02 2.52e-01 0.353000
GO:0072344 rescue of stalled ribosome 26 2.63e-02 -2.52e-01 0.269000
GO:0097730 non-motile cilium 14 1.03e-01 -2.52e-01 0.479000
GO:0030544 Hsp70 protein binding 29 1.94e-02 -2.51e-01 0.224000
GO:0030020 extracellular matrix structural constituent conferring tensile strength 19 5.90e-02 2.50e-01 0.384000
GO:0031507 heterochromatin formation 27 2.53e-02 -2.49e-01 0.262000
GO:0030324 lung development 33 1.35e-02 2.49e-01 0.184000
GO:0001657 ureteric bud development 14 1.08e-01 -2.48e-01 0.488000
GO:0009611 response to wounding 21 4.95e-02 2.48e-01 0.356000
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 11 1.55e-01 -2.47e-01 0.569000
GO:0043024 ribosomal small subunit binding 13 1.24e-01 -2.47e-01 0.517000
GO:0007249 canonical NF-kappaB signal transduction 18 7.09e-02 -2.46e-01 0.405000
GO:0010575 positive regulation of vascular endothelial growth factor production 14 1.12e-01 2.45e-01 0.495000
GO:0038062 protein tyrosine kinase collagen receptor activity 14 1.13e-01 2.45e-01 0.495000
GO:0007288 sperm axoneme assembly 17 8.04e-02 -2.45e-01 0.426000
GO:0008053 mitochondrial fusion 17 8.08e-02 -2.45e-01 0.427000
GO:0042060 wound healing 28 2.54e-02 2.44e-01 0.262000
GO:0006612 protein targeting to membrane 24 3.86e-02 -2.44e-01 0.325000
GO:0033617 mitochondrial cytochrome c oxidase assembly 13 1.29e-01 2.43e-01 0.525000
GO:0099171 presynaptic modulation of chemical synaptic transmission 11 1.64e-01 -2.43e-01 0.585000
GO:0005681 spliceosomal complex 43 5.94e-03 -2.43e-01 0.104000
GO:0008180 COP9 signalosome 22 4.95e-02 -2.42e-01 0.356000
GO:0060828 regulation of canonical Wnt signaling pathway 18 7.56e-02 2.42e-01 0.415000
GO:0032206 positive regulation of telomere maintenance 14 1.18e-01 -2.41e-01 0.510000
GO:0030593 neutrophil chemotaxis 13 1.33e-01 2.41e-01 0.529000
GO:0009791 post-embryonic development 37 1.13e-02 2.41e-01 0.168000
GO:0003756 protein disulfide isomerase activity 10 1.91e-01 -2.39e-01 0.625000
GO:0031648 protein destabilization 32 1.97e-02 2.38e-01 0.224000
GO:0005903 brush border 19 7.33e-02 -2.37e-01 0.411000
GO:0019216 regulation of lipid metabolic process 10 1.94e-01 2.37e-01 0.633000
GO:0001508 action potential 11 1.74e-01 2.37e-01 0.610000
GO:0005004 GPI-linked ephrin receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0005007 fibroblast growth factor receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0005011 macrophage colony-stimulating factor receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0005018 platelet-derived growth factor alpha-receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0005020 stem cell factor receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0008288 boss receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway 13 1.40e-01 2.37e-01 0.530000
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway 13 1.40e-01 2.37e-01 0.530000
GO:0036332 placental growth factor receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0038145 macrophage colony-stimulating factor signaling pathway 13 1.40e-01 2.37e-01 0.530000
GO:0060175 brain-derived neurotrophic factor receptor activity 13 1.40e-01 2.37e-01 0.530000
GO:0050919 negative chemotaxis 22 5.48e-02 2.37e-01 0.368000
GO:0006284 base-excision repair 17 9.15e-02 -2.36e-01 0.451000
GO:0000974 Prp19 complex 10 1.96e-01 -2.36e-01 0.634000
GO:0001894 tissue homeostasis 13 1.41e-01 2.36e-01 0.530000
GO:0044183 protein folding chaperone 21 6.18e-02 -2.35e-01 0.388000
GO:0044331 cell-cell adhesion mediated by cadherin 12 1.59e-01 2.35e-01 0.575000
GO:2000378 negative regulation of reactive oxygen species metabolic process 10 2.00e-01 2.34e-01 0.637000
GO:0070888 E-box binding 21 6.34e-02 2.34e-01 0.390000
GO:0002102 podosome 19 7.76e-02 -2.34e-01 0.421000
GO:0060325 face morphogenesis 21 6.36e-02 2.34e-01 0.390000
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 35 1.69e-02 2.33e-01 0.206000
GO:0006898 receptor-mediated endocytosis 24 4.81e-02 2.33e-01 0.356000
GO:0010569 regulation of double-strand break repair via homologous recombination 10 2.02e-01 -2.33e-01 0.639000
GO:0051894 positive regulation of focal adhesion assembly 15 1.18e-01 -2.33e-01 0.510000
GO:0051539 4 iron, 4 sulfur cluster binding 34 1.90e-02 -2.32e-01 0.224000
GO:0003743 translation initiation factor activity 39 1.23e-02 -2.32e-01 0.176000
GO:0032543 mitochondrial translation 22 6.01e-02 -2.32e-01 0.384000
GO:0043484 regulation of RNA splicing 23 5.65e-02 2.30e-01 0.378000
GO:0003724 RNA helicase activity 37 1.59e-02 -2.29e-01 0.201000
GO:0062023 collagen-containing extracellular matrix 74 6.60e-04 2.29e-01 0.030000
GO:0016282 eukaryotic 43S preinitiation complex 14 1.38e-01 -2.29e-01 0.530000
GO:0010507 negative regulation of autophagy 22 6.41e-02 2.28e-01 0.390000
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10 2.12e-01 -2.28e-01 0.648000
GO:0070507 regulation of microtubule cytoskeleton organization 14 1.40e-01 2.28e-01 0.530000
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 84 3.09e-04 2.28e-01 0.022800
GO:0031072 heat shock protein binding 26 4.46e-02 -2.28e-01 0.352000
GO:0050699 WW domain binding 11 1.92e-01 -2.27e-01 0.625000
GO:0031398 positive regulation of protein ubiquitination 40 1.30e-02 -2.27e-01 0.181000
GO:0097194 execution phase of apoptosis 10 2.14e-01 2.27e-01 0.649000
GO:0005643 nuclear pore 33 2.45e-02 -2.26e-01 0.259000
GO:0000775 chromosome, centromeric region 31 3.00e-02 -2.25e-01 0.292000
GO:0045746 negative regulation of Notch signaling pathway 15 1.32e-01 -2.25e-01 0.528000
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 16 1.20e-01 -2.24e-01 0.513000
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 30 3.42e-02 -2.23e-01 0.309000
GO:0008033 tRNA processing 15 1.35e-01 -2.23e-01 0.530000
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 17 1.13e-01 2.22e-01 0.495000
GO:0072583 clathrin-dependent endocytosis 19 9.42e-02 2.22e-01 0.456000
GO:0005109 frizzled binding 18 1.03e-01 2.22e-01 0.479000
GO:0009617 response to bacterium 37 1.96e-02 -2.22e-01 0.224000
GO:0006275 regulation of DNA replication 24 6.06e-02 -2.21e-01 0.384000
GO:0051259 protein complex oligomerization 14 1.52e-01 -2.21e-01 0.559000
GO:0006952 defense response 10 2.26e-01 -2.21e-01 0.669000
GO:0120020 cholesterol transfer activity 12 1.85e-01 2.21e-01 0.617000
GO:0048167 regulation of synaptic plasticity 16 1.27e-01 2.21e-01 0.522000
GO:0035278 miRNA-mediated gene silencing by inhibition of translation 13 1.69e-01 2.20e-01 0.596000
GO:0008306 associative learning 11 2.06e-01 2.20e-01 0.646000
GO:0071466 cellular response to xenobiotic stimulus 25 5.70e-02 -2.20e-01 0.378000
GO:0032008 positive regulation of TOR signaling 12 1.88e-01 2.20e-01 0.618000
GO:0003777 microtubule motor activity 23 6.88e-02 -2.19e-01 0.402000
GO:0003925 G protein activity 18 1.08e-01 -2.19e-01 0.488000
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity 16 1.31e-01 -2.18e-01 0.526000
GO:0006672 ceramide metabolic process 10 2.32e-01 2.18e-01 0.677000
GO:0007042 lysosomal lumen acidification 10 2.33e-01 2.18e-01 0.677000
GO:0017056 structural constituent of nuclear pore 19 1.00e-01 -2.18e-01 0.473000
GO:0006289 nucleotide-excision repair 22 7.73e-02 -2.18e-01 0.421000
GO:0050661 NADP binding 13 1.76e-01 -2.17e-01 0.610000
GO:0008201 heparin binding 56 5.03e-03 2.17e-01 0.094000
GO:0048863 stem cell differentiation 22 7.95e-02 -2.16e-01 0.424000
GO:0061608 nuclear import signal receptor activity 14 1.63e-01 -2.15e-01 0.585000
GO:0030016 myofibril 14 1.64e-01 2.15e-01 0.585000
GO:0003151 outflow tract morphogenesis 19 1.05e-01 2.15e-01 0.483000
GO:0071300 cellular response to retinoic acid 17 1.28e-01 -2.13e-01 0.524000
GO:0010718 positive regulation of epithelial to mesenchymal transition 26 6.06e-02 2.13e-01 0.384000
GO:0006611 protein export from nucleus 22 8.52e-02 -2.12e-01 0.439000
GO:0043627 response to estrogen 10 2.46e-01 -2.12e-01 0.697000
GO:0048536 spleen development 23 7.91e-02 2.12e-01 0.424000
GO:0000049 tRNA binding 52 8.45e-03 -2.11e-01 0.135000
GO:0010811 positive regulation of cell-substrate adhesion 13 1.87e-01 2.11e-01 0.618000
GO:0046847 filopodium assembly 11 2.26e-01 -2.11e-01 0.669000
GO:0000792 heterochromatin 19 1.12e-01 -2.10e-01 0.495000
GO:0009954 proximal/distal pattern formation 14 1.73e-01 -2.10e-01 0.608000
GO:0061484 hematopoietic stem cell homeostasis 11 2.28e-01 2.10e-01 0.671000
GO:0017166 vinculin binding 10 2.50e-01 2.10e-01 0.698000
GO:0090090 negative regulation of canonical Wnt signaling pathway 70 2.41e-03 2.10e-01 0.059200
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 14 1.74e-01 -2.10e-01 0.610000
GO:0051592 response to calcium ion 20 1.06e-01 -2.09e-01 0.483000
GO:0035924 cellular response to vascular endothelial growth factor stimulus 16 1.48e-01 2.09e-01 0.549000
GO:0016529 sarcoplasmic reticulum 14 1.76e-01 2.09e-01 0.610000
GO:0006468 protein phosphorylation 12 2.10e-01 2.09e-01 0.648000
GO:0000774 adenyl-nucleotide exchange factor activity 12 2.11e-01 -2.09e-01 0.648000
GO:0000118 histone deacetylase complex 22 9.03e-02 2.09e-01 0.449000
GO:0006364 rRNA processing 65 3.68e-03 -2.08e-01 0.077500
GO:0035024 negative regulation of Rho protein signal transduction 14 1.78e-01 -2.08e-01 0.610000
GO:0038066 p38MAPK cascade 12 2.13e-01 -2.08e-01 0.648000
GO:0000146 microfilament motor activity 21 1.02e-01 2.06e-01 0.476000
GO:0032922 circadian regulation of gene expression 34 3.84e-02 2.05e-01 0.325000
GO:0000387 spliceosomal snRNP assembly 17 1.43e-01 -2.05e-01 0.536000
GO:0043022 ribosome binding 46 1.63e-02 -2.05e-01 0.202000
GO:0043588 skin development 24 8.29e-02 2.05e-01 0.434000
GO:0090263 positive regulation of canonical Wnt signaling pathway 63 5.13e-03 2.04e-01 0.094600
GO:0007080 mitotic metaphase chromosome alignment 23 9.20e-02 -2.03e-01 0.451000
GO:0006488 dolichol-linked oligosaccharide biosynthetic process 14 1.90e-01 -2.02e-01 0.623000
GO:0004713 protein tyrosine kinase activity 35 3.85e-02 2.02e-01 0.325000
GO:0030513 positive regulation of BMP signaling pathway 20 1.19e-01 2.01e-01 0.510000
GO:0045722 positive regulation of gluconeogenesis 11 2.48e-01 2.01e-01 0.698000
GO:0043596 nuclear replication fork 10 2.71e-01 -2.01e-01 0.708000
GO:0030017 sarcomere 12 2.29e-01 -2.00e-01 0.673000
GO:0090102 cochlea development 13 2.11e-01 -2.00e-01 0.648000
GO:0051016 barbed-end actin filament capping 16 1.66e-01 -2.00e-01 0.590000
GO:1904047 S-adenosyl-L-methionine binding 13 2.13e-01 -2.00e-01 0.648000
GO:0008305 integrin complex 17 1.55e-01 -1.99e-01 0.568000
GO:0007043 cell-cell junction assembly 10 2.76e-01 1.99e-01 0.714000
GO:0035567 non-canonical Wnt signaling pathway 14 1.98e-01 1.99e-01 0.637000
GO:0001958 endochondral ossification 15 1.83e-01 1.98e-01 0.613000
GO:0030225 macrophage differentiation 11 2.55e-01 1.98e-01 0.701000
GO:0000939 inner kinetochore 10 2.79e-01 -1.98e-01 0.715000
GO:0051881 regulation of mitochondrial membrane potential 14 2.01e-01 1.98e-01 0.638000
GO:0019902 phosphatase binding 22 1.10e-01 1.97e-01 0.492000
GO:0006730 one-carbon metabolic process 13 2.19e-01 -1.97e-01 0.658000
GO:0005978 glycogen biosynthetic process 11 2.59e-01 -1.97e-01 0.701000
GO:0004519 endonuclease activity 13 2.21e-01 1.96e-01 0.660000
GO:2001222 regulation of neuron migration 10 2.83e-01 -1.96e-01 0.719000
GO:0034707 chloride channel complex 12 2.39e-01 -1.96e-01 0.689000
GO:0031012 extracellular matrix 90 1.32e-03 1.96e-01 0.044300
GO:0071549 cellular response to dexamethasone stimulus 11 2.60e-01 1.96e-01 0.702000
GO:0051059 NF-kappaB binding 22 1.12e-01 -1.96e-01 0.495000
GO:0097546 ciliary base 17 1.65e-01 -1.95e-01 0.586000
GO:0045824 negative regulation of innate immune response 16 1.79e-01 -1.94e-01 0.610000
GO:0000781 chromosome, telomeric region 75 3.71e-03 -1.94e-01 0.077500
GO:0001725 stress fiber 42 2.99e-02 -1.94e-01 0.292000
GO:0010842 retina layer formation 12 2.45e-01 1.94e-01 0.697000
GO:1902476 chloride transmembrane transport 39 3.67e-02 1.93e-01 0.323000
GO:0090316 positive regulation of intracellular protein transport 14 2.12e-01 -1.93e-01 0.648000
GO:0030838 positive regulation of actin filament polymerization 26 8.91e-02 1.93e-01 0.446000
GO:0048278 vesicle docking 13 2.29e-01 -1.93e-01 0.673000
GO:0009982 pseudouridine synthase activity 12 2.50e-01 -1.92e-01 0.698000
GO:0045724 positive regulation of cilium assembly 13 2.31e-01 1.92e-01 0.676000
GO:0045862 positive regulation of proteolysis 12 2.53e-01 1.91e-01 0.699000
GO:0008333 endosome to lysosome transport 32 6.23e-02 1.90e-01 0.390000
GO:0009615 response to virus 31 6.81e-02 -1.89e-01 0.400000
GO:0005763 mitochondrial small ribosomal subunit 21 1.35e-01 -1.89e-01 0.530000
GO:0006446 regulation of translational initiation 17 1.79e-01 -1.88e-01 0.610000
GO:0034332 adherens junction organization 13 2.40e-01 1.88e-01 0.690000
GO:0000166 nucleotide binding 37 4.80e-02 -1.88e-01 0.356000
GO:0043124 negative regulation of canonical NF-kappaB signal transduction 35 5.46e-02 -1.88e-01 0.368000
GO:0002062 chondrocyte differentiation 22 1.28e-01 1.87e-01 0.525000
GO:0071320 cellular response to cAMP 19 1.58e-01 -1.87e-01 0.572000
GO:0006635 fatty acid beta-oxidation 26 9.91e-02 -1.87e-01 0.471000
GO:0070411 I-SMAD binding 11 2.84e-01 1.87e-01 0.719000
GO:0150052 regulation of postsynapse assembly 13 2.47e-01 -1.85e-01 0.698000
GO:0055088 lipid homeostasis 19 1.62e-01 1.85e-01 0.583000
GO:0051056 regulation of small GTPase mediated signal transduction 16 2.00e-01 1.85e-01 0.638000
GO:0051131 chaperone-mediated protein complex assembly 14 2.31e-01 -1.85e-01 0.676000
GO:0045184 establishment of protein localization 17 1.87e-01 1.85e-01 0.618000
GO:0034067 protein localization to Golgi apparatus 13 2.49e-01 -1.85e-01 0.698000
GO:0050750 low-density lipoprotein particle receptor binding 13 2.49e-01 1.85e-01 0.698000
GO:0030057 desmosome 12 2.71e-01 1.83e-01 0.708000
GO:0012507 ER to Golgi transport vesicle membrane 11 2.95e-01 1.82e-01 0.725000
GO:0033017 sarcoplasmic reticulum membrane 10 3.18e-01 1.82e-01 0.747000
GO:0060395 SMAD protein signal transduction 14 2.38e-01 1.82e-01 0.687000
GO:0035914 skeletal muscle cell differentiation 24 1.23e-01 1.82e-01 0.516000
GO:0042102 positive regulation of T cell proliferation 10 3.21e-01 1.81e-01 0.748000
GO:0051393 alpha-actinin binding 10 3.21e-01 -1.81e-01 0.748000
GO:0000776 kinetochore 90 2.98e-03 -1.81e-01 0.066100
GO:0032735 positive regulation of interleukin-12 production 12 2.78e-01 -1.81e-01 0.715000
GO:0043029 T cell homeostasis 13 2.59e-01 1.81e-01 0.701000
GO:0004602 glutathione peroxidase activity 12 2.79e-01 1.80e-01 0.715000
GO:0006281 DNA repair 95 2.41e-03 -1.80e-01 0.059200
GO:0071347 cellular response to interleukin-1 17 1.99e-01 -1.80e-01 0.637000
GO:0005686 U2 snRNP 16 2.13e-01 -1.80e-01 0.648000
GO:0060326 cell chemotaxis 28 1.01e-01 -1.79e-01 0.473000
GO:0061136 regulation of proteasomal protein catabolic process 11 3.04e-01 -1.79e-01 0.736000
GO:0021915 neural tube development 17 2.01e-01 1.79e-01 0.638000
GO:1904263 positive regulation of TORC1 signaling 35 6.71e-02 1.79e-01 0.398000
GO:0043997 histone H4K12 acetyltransferase activity 10 3.28e-01 1.79e-01 0.755000
GO:1990247 N6-methyladenosine-containing RNA reader activity 10 3.28e-01 1.78e-01 0.755000
GO:0030374 nuclear receptor coactivator activity 30 9.09e-02 -1.78e-01 0.450000
GO:0050852 T cell receptor signaling pathway 49 3.10e-02 1.78e-01 0.294000
GO:0030295 protein kinase activator activity 21 1.58e-01 1.78e-01 0.572000
GO:0006783 heme biosynthetic process 10 3.30e-01 -1.78e-01 0.755000
GO:0030900 forebrain development 20 1.69e-01 1.78e-01 0.596000
GO:0071011 precatalytic spliceosome 12 2.87e-01 -1.78e-01 0.719000
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 13 2.68e-01 -1.78e-01 0.708000
GO:0030215 semaphorin receptor binding 13 2.68e-01 1.77e-01 0.708000
GO:1903076 regulation of protein localization to plasma membrane 18 1.93e-01 -1.77e-01 0.628000
GO:0008094 ATP-dependent activity, acting on DNA 11 3.10e-01 -1.77e-01 0.740000
GO:0008543 fibroblast growth factor receptor signaling pathway 36 6.74e-02 1.76e-01 0.398000
GO:0032880 regulation of protein localization 41 5.15e-02 -1.76e-01 0.363000
GO:0070830 bicellular tight junction assembly 19 1.86e-01 1.75e-01 0.617000
GO:0040018 positive regulation of multicellular organism growth 16 2.25e-01 1.75e-01 0.669000
GO:0016363 nuclear matrix 46 4.01e-02 -1.75e-01 0.333000
GO:1990391 DNA repair complex 10 3.40e-01 -1.74e-01 0.759000
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 19 1.91e-01 1.73e-01 0.625000
GO:0019221 cytokine-mediated signaling pathway 45 4.50e-02 1.73e-01 0.352000
GO:0031369 translation initiation factor binding 12 3.00e-01 -1.73e-01 0.732000
GO:0006869 lipid transport 30 1.02e-01 1.73e-01 0.476000
GO:1901981 phosphatidylinositol phosphate binding 15 2.48e-01 1.72e-01 0.698000
GO:1904646 cellular response to amyloid-beta 10 3.46e-01 1.72e-01 0.765000
GO:0045785 positive regulation of cell adhesion 15 2.51e-01 1.71e-01 0.698000
GO:0046966 nuclear thyroid hormone receptor binding 15 2.51e-01 1.71e-01 0.698000
GO:0031397 negative regulation of protein ubiquitination 33 8.95e-02 -1.71e-01 0.446000
GO:0045672 positive regulation of osteoclast differentiation 12 3.06e-01 1.71e-01 0.738000
GO:0043122 regulation of canonical NF-kappaB signal transduction 17 2.23e-01 -1.71e-01 0.663000
GO:0060412 ventricular septum morphogenesis 16 2.37e-01 1.71e-01 0.686000
GO:0015701 bicarbonate transport 12 3.06e-01 1.71e-01 0.738000
GO:0004879 nuclear receptor activity 38 6.90e-02 1.71e-01 0.402000
GO:0015631 tubulin binding 29 1.12e-01 -1.70e-01 0.495000
GO:0006351 DNA-templated transcription 36 7.78e-02 -1.70e-01 0.421000
GO:0022904 respiratory electron transport chain 14 2.72e-01 1.70e-01 0.710000
GO:0042572 retinol metabolic process 13 2.91e-01 -1.69e-01 0.722000
GO:0046329 negative regulation of JNK cascade 12 3.11e-01 1.69e-01 0.740000
GO:0046488 phosphatidylinositol metabolic process 13 2.93e-01 1.68e-01 0.723000
GO:0030534 adult behavior 10 3.59e-01 1.68e-01 0.770000
GO:0051781 positive regulation of cell division 13 2.97e-01 1.67e-01 0.727000
GO:0005543 phospholipid binding 39 7.12e-02 -1.67e-01 0.405000
GO:0051453 regulation of intracellular pH 14 2.80e-01 1.67e-01 0.715000
GO:0099175 regulation of postsynapse organization 19 2.08e-01 1.67e-01 0.648000
GO:0007179 transforming growth factor beta receptor signaling pathway 48 4.61e-02 1.67e-01 0.353000
GO:0061744 motor behavior 16 2.49e-01 1.66e-01 0.698000
GO:0005871 kinesin complex 22 1.78e-01 -1.66e-01 0.610000
GO:0051480 regulation of cytosolic calcium ion concentration 13 3.02e-01 -1.65e-01 0.734000
GO:0034599 cellular response to oxidative stress 44 5.79e-02 -1.65e-01 0.378000
GO:0001772 immunological synapse 22 1.82e-01 -1.65e-01 0.610000
GO:0006367 transcription initiation at RNA polymerase II promoter 20 2.04e-01 -1.64e-01 0.641000
GO:0071944 cell periphery 12 3.25e-01 -1.64e-01 0.752000
GO:0030326 embryonic limb morphogenesis 14 2.88e-01 1.64e-01 0.720000
GO:0048511 rhythmic process 25 1.57e-01 -1.64e-01 0.571000
GO:0098839 postsynaptic density membrane 34 1.00e-01 1.63e-01 0.473000
GO:0000226 microtubule cytoskeleton organization 69 1.95e-02 -1.63e-01 0.224000
GO:0000422 autophagy of mitochondrion 14 2.93e-01 -1.62e-01 0.723000
GO:0060070 canonical Wnt signaling pathway 59 3.11e-02 1.62e-01 0.294000
GO:0000132 establishment of mitotic spindle orientation 26 1.52e-01 -1.62e-01 0.559000
GO:0030150 protein import into mitochondrial matrix 12 3.30e-01 -1.62e-01 0.755000
GO:0032154 cleavage furrow 28 1.37e-01 -1.62e-01 0.530000
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 13 3.11e-01 -1.62e-01 0.740000
GO:0051787 misfolded protein binding 12 3.31e-01 -1.62e-01 0.755000
GO:0061436 establishment of skin barrier 13 3.12e-01 -1.62e-01 0.740000
GO:0003735 structural constituent of ribosome 118 2.43e-03 1.62e-01 0.059200
GO:0070371 ERK1 and ERK2 cascade 20 2.11e-01 1.62e-01 0.648000
GO:1990830 cellular response to leukemia inhibitory factor 67 2.24e-02 -1.61e-01 0.243000
GO:0006376 mRNA splice site recognition 12 3.33e-01 -1.61e-01 0.758000
GO:0042274 ribosomal small subunit biogenesis 44 6.42e-02 -1.61e-01 0.390000
GO:0031462 Cul2-RING ubiquitin ligase complex 15 2.80e-01 -1.61e-01 0.715000
GO:0030198 extracellular matrix organization 79 1.36e-02 1.61e-01 0.184000
GO:0005525 GTP binding 213 5.69e-05 -1.60e-01 0.015700
GO:0072686 mitotic spindle 69 2.14e-02 -1.60e-01 0.237000
GO:0004364 glutathione transferase activity 10 3.81e-01 -1.60e-01 0.784000
GO:0035613 RNA stem-loop binding 11 3.59e-01 1.60e-01 0.770000
GO:0032040 small-subunit processome 59 3.40e-02 -1.60e-01 0.309000
GO:1902018 negative regulation of cilium assembly 13 3.19e-01 -1.60e-01 0.747000
GO:0071346 cellular response to type II interferon 23 1.86e-01 -1.59e-01 0.617000
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 12 3.39e-01 -1.59e-01 0.759000
GO:0032743 positive regulation of interleukin-2 production 16 2.70e-01 1.59e-01 0.708000
GO:0048008 platelet-derived growth factor receptor signaling pathway 17 2.56e-01 1.59e-01 0.701000
GO:0051020 GTPase binding 15 2.86e-01 1.59e-01 0.719000
GO:0007155 cell adhesion 104 5.17e-03 1.59e-01 0.094600
GO:2000648 positive regulation of stem cell proliferation 12 3.41e-01 1.59e-01 0.759000
GO:0007623 circadian rhythm 18 2.46e-01 1.58e-01 0.697000
GO:0003924 GTPase activity 176 3.08e-04 -1.58e-01 0.022800
GO:0043113 receptor clustering 11 3.65e-01 -1.58e-01 0.775000
GO:0001786 phosphatidylserine binding 24 1.81e-01 1.58e-01 0.610000
GO:0098761 cellular response to interleukin-7 10 3.88e-01 -1.58e-01 0.784000
GO:0071363 cellular response to growth factor stimulus 20 2.23e-01 -1.58e-01 0.663000
GO:1990023 mitotic spindle midzone 10 3.88e-01 -1.58e-01 0.784000
GO:0005778 peroxisomal membrane 27 1.57e-01 -1.57e-01 0.571000
GO:0070403 NAD+ binding 11 3.66e-01 -1.57e-01 0.776000
GO:0006260 DNA replication 34 1.12e-01 -1.57e-01 0.495000
GO:0050680 negative regulation of epithelial cell proliferation 24 1.82e-01 1.57e-01 0.611000
GO:0030018 Z disc 51 5.23e-02 -1.57e-01 0.366000
GO:0006397 mRNA processing 72 2.13e-02 -1.57e-01 0.237000
GO:0030286 dynein complex 11 3.67e-01 1.57e-01 0.776000
GO:0000956 nuclear-transcribed mRNA catabolic process 12 3.46e-01 1.57e-01 0.766000
GO:0046718 symbiont entry into host cell 22 2.04e-01 1.57e-01 0.641000
GO:0030183 B cell differentiation 26 1.68e-01 1.56e-01 0.594000
GO:0032481 positive regulation of type I interferon production 18 2.53e-01 1.56e-01 0.699000
GO:0002244 hematopoietic progenitor cell differentiation 34 1.17e-01 -1.55e-01 0.507000
GO:0015813 L-glutamate transmembrane transport 11 3.73e-01 1.55e-01 0.784000
GO:0032588 trans-Golgi network membrane 27 1.63e-01 1.55e-01 0.585000
GO:0070098 chemokine-mediated signaling pathway 10 3.97e-01 1.55e-01 0.784000
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 35 1.13e-01 1.55e-01 0.497000
GO:0042277 peptide binding 10 3.97e-01 -1.55e-01 0.784000
GO:0005008 hepatocyte growth factor receptor activity 14 3.17e-01 1.54e-01 0.747000
GO:0007173 epidermal growth factor receptor signaling pathway 39 9.66e-02 1.54e-01 0.464000
GO:0045070 positive regulation of viral genome replication 19 2.46e-01 -1.54e-01 0.697000
GO:0034727 piecemeal microautophagy of the nucleus 13 3.38e-01 1.53e-01 0.758000
GO:0005923 bicellular tight junction 50 6.08e-02 1.53e-01 0.384000
GO:0071479 cellular response to ionizing radiation 22 2.13e-01 1.53e-01 0.648000
GO:0006654 phosphatidic acid biosynthetic process 12 3.58e-01 1.53e-01 0.770000
GO:0000145 exocyst 11 3.80e-01 -1.53e-01 0.784000
GO:0033173 calcineurin-NFAT signaling cascade 10 4.03e-01 1.53e-01 0.784000
GO:0042327 positive regulation of phosphorylation 12 3.61e-01 1.52e-01 0.771000
GO:0001917 photoreceptor inner segment 24 1.96e-01 -1.52e-01 0.635000
GO:0043995 histone H4K5 acetyltransferase activity 10 4.04e-01 1.52e-01 0.784000
GO:0043996 histone H4K8 acetyltransferase activity 10 4.04e-01 1.52e-01 0.784000
GO:0005049 nuclear export signal receptor activity 10 4.04e-01 -1.52e-01 0.784000
GO:0072657 protein localization to membrane 19 2.51e-01 1.52e-01 0.698000
GO:0070085 glycosylation 14 3.24e-01 1.52e-01 0.751000
GO:0006909 phagocytosis 23 2.07e-01 -1.52e-01 0.647000
GO:0035035 histone acetyltransferase binding 12 3.63e-01 -1.52e-01 0.772000
GO:0046849 bone remodeling 10 4.06e-01 1.52e-01 0.784000
GO:0043296 apical junction complex 10 4.07e-01 1.51e-01 0.784000
GO:0051010 microtubule plus-end binding 11 3.86e-01 -1.51e-01 0.784000
GO:0030041 actin filament polymerization 16 2.97e-01 1.51e-01 0.727000
GO:0008277 regulation of G protein-coupled receptor signaling pathway 15 3.13e-01 1.50e-01 0.740000
GO:0045190 isotype switching 13 3.49e-01 -1.50e-01 0.770000
GO:0016925 protein sumoylation 19 2.59e-01 -1.50e-01 0.701000
GO:0007218 neuropeptide signaling pathway 16 3.01e-01 -1.50e-01 0.732000
GO:0006493 protein O-linked glycosylation 32 1.43e-01 1.50e-01 0.536000
GO:0051301 cell division 144 2.07e-03 -1.49e-01 0.055000
GO:0035861 site of double-strand break 58 5.04e-02 -1.49e-01 0.359000
GO:0007275 multicellular organism development 27 1.81e-01 1.49e-01 0.610000
GO:0071816 tail-anchored membrane protein insertion into ER membrane 10 4.16e-01 -1.49e-01 0.786000
GO:0016442 RISC complex 11 3.94e-01 1.49e-01 0.784000
GO:0005788 endoplasmic reticulum lumen 40 1.05e-01 -1.48e-01 0.483000
GO:0071897 DNA biosynthetic process 12 3.76e-01 -1.48e-01 0.784000
GO:0005730 nucleolus 443 1.16e-07 -1.48e-01 0.000205
GO:0045648 positive regulation of erythrocyte differentiation 18 2.79e-01 -1.48e-01 0.715000
GO:0043153 entrainment of circadian clock by photoperiod 13 3.57e-01 1.48e-01 0.770000
GO:0007040 lysosome organization 33 1.43e-01 1.47e-01 0.536000
GO:0046034 ATP metabolic process 12 3.77e-01 -1.47e-01 0.784000
GO:0032570 response to progesterone 13 3.59e-01 -1.47e-01 0.770000
GO:0043616 keratinocyte proliferation 11 3.99e-01 -1.47e-01 0.784000
GO:0030901 midbrain development 11 4.00e-01 1.47e-01 0.784000
GO:0060216 definitive hemopoiesis 10 4.23e-01 1.46e-01 0.787000
GO:1902895 positive regulation of miRNA transcription 25 2.06e-01 1.46e-01 0.646000
GO:0072593 reactive oxygen species metabolic process 16 3.12e-01 1.46e-01 0.740000
GO:0031929 TOR signaling 13 3.63e-01 1.46e-01 0.772000
GO:0016459 myosin complex 26 2.01e-01 1.45e-01 0.638000
GO:0070402 NADPH binding 10 4.29e-01 -1.44e-01 0.790000
GO:0003774 cytoskeletal motor activity 14 3.50e-01 1.44e-01 0.770000
GO:0044297 cell body 26 2.04e-01 -1.44e-01 0.641000
GO:0003690 double-stranded DNA binding 35 1.40e-01 -1.44e-01 0.530000
GO:0006406 mRNA export from nucleus 28 1.88e-01 -1.44e-01 0.618000
GO:0004888 transmembrane signaling receptor activity 23 2.33e-01 1.44e-01 0.677000
GO:0035176 social behavior 16 3.21e-01 1.43e-01 0.748000
GO:0050679 positive regulation of epithelial cell proliferation 20 2.67e-01 1.43e-01 0.708000
GO:0034704 calcium channel complex 10 4.33e-01 1.43e-01 0.794000
GO:0051642 centrosome localization 13 3.73e-01 -1.43e-01 0.784000
GO:0060236 regulation of mitotic spindle organization 12 3.92e-01 -1.43e-01 0.784000
GO:0071013 catalytic step 2 spliceosome 52 7.55e-02 -1.43e-01 0.415000
GO:0030030 cell projection organization 13 3.74e-01 -1.43e-01 0.784000
GO:0090128 regulation of synapse maturation 11 4.14e-01 -1.42e-01 0.785000
GO:0008013 beta-catenin binding 48 8.82e-02 1.42e-01 0.445000
GO:0030276 clathrin binding 17 3.11e-01 -1.42e-01 0.740000
GO:0007163 establishment or maintenance of cell polarity 13 3.76e-01 -1.42e-01 0.784000
GO:0030182 neuron differentiation 56 6.74e-02 1.41e-01 0.398000
GO:0051087 protein-folding chaperone binding 56 6.75e-02 -1.41e-01 0.398000
GO:0048026 positive regulation of mRNA splicing, via spliceosome 12 3.97e-01 -1.41e-01 0.784000
GO:0035098 ESC/E(Z) complex 12 3.97e-01 -1.41e-01 0.784000
GO:0035102 PRC1 complex 13 3.78e-01 1.41e-01 0.784000
GO:0032391 photoreceptor connecting cilium 19 2.87e-01 -1.41e-01 0.719000
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 17 3.15e-01 -1.41e-01 0.742000
GO:0099523 presynaptic cytosol 11 4.19e-01 -1.41e-01 0.787000
GO:0030027 lamellipodium 92 2.00e-02 -1.40e-01 0.225000
GO:0007281 germ cell development 14 3.63e-01 -1.40e-01 0.772000
GO:0001937 negative regulation of endothelial cell proliferation 12 4.00e-01 -1.40e-01 0.784000
GO:0032722 positive regulation of chemokine production 11 4.22e-01 1.40e-01 0.787000
GO:0031297 replication fork processing 26 2.17e-01 -1.40e-01 0.653000
GO:0007628 adult walking behavior 11 4.22e-01 1.40e-01 0.787000
GO:0140311 protein sequestering activity 18 3.06e-01 -1.39e-01 0.738000
GO:0042752 regulation of circadian rhythm 27 2.11e-01 1.39e-01 0.648000
GO:0030514 negative regulation of BMP signaling pathway 26 2.21e-01 1.39e-01 0.660000
GO:0048384 retinoic acid receptor signaling pathway 11 4.26e-01 -1.39e-01 0.787000
GO:0031683 G-protein beta/gamma-subunit complex binding 10 4.48e-01 -1.38e-01 0.794000
GO:0032720 negative regulation of tumor necrosis factor production 18 3.10e-01 -1.38e-01 0.740000
GO:0007064 mitotic sister chromatid cohesion 10 4.49e-01 -1.38e-01 0.794000
GO:0010976 positive regulation of neuron projection development 29 1.99e-01 1.38e-01 0.637000
GO:0016581 NuRD complex 10 4.51e-01 -1.38e-01 0.794000
GO:0031490 chromatin DNA binding 41 1.28e-01 1.37e-01 0.524000
GO:0001947 heart looping 22 2.65e-01 1.37e-01 0.708000
GO:0016757 glycosyltransferase activity 15 3.58e-01 1.37e-01 0.770000
GO:0032924 activin receptor signaling pathway 12 4.12e-01 1.37e-01 0.784000
GO:0012506 vesicle membrane 15 3.59e-01 1.37e-01 0.770000
GO:0001516 prostaglandin biosynthetic process 10 4.54e-01 -1.37e-01 0.794000
GO:1904294 positive regulation of ERAD pathway 10 4.55e-01 -1.37e-01 0.794000
GO:0046580 negative regulation of Ras protein signal transduction 13 3.94e-01 1.37e-01 0.784000
GO:0005637 nuclear inner membrane 24 2.47e-01 -1.37e-01 0.698000
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 13 3.94e-01 -1.37e-01 0.784000
GO:1901673 regulation of mitotic spindle assembly 16 3.45e-01 -1.36e-01 0.765000
GO:0006874 intracellular calcium ion homeostasis 38 1.46e-01 -1.36e-01 0.545000
GO:0045739 positive regulation of DNA repair 20 2.92e-01 -1.36e-01 0.722000
GO:0048701 embryonic cranial skeleton morphogenesis 13 3.95e-01 1.36e-01 0.784000
GO:0051225 spindle assembly 21 2.81e-01 -1.36e-01 0.716000
GO:0051649 establishment of localization in cell 41 1.32e-01 -1.36e-01 0.528000
GO:0070372 regulation of ERK1 and ERK2 cascade 13 3.97e-01 -1.36e-01 0.784000
GO:0031573 mitotic intra-S DNA damage checkpoint signaling 11 4.35e-01 -1.36e-01 0.794000
GO:0005005 transmembrane-ephrin receptor activity 15 3.63e-01 1.36e-01 0.772000
GO:0040029 epigenetic regulation of gene expression 18 3.19e-01 1.36e-01 0.747000
GO:0061025 membrane fusion 21 2.82e-01 -1.36e-01 0.719000
GO:0010761 fibroblast migration 10 4.58e-01 1.35e-01 0.794000
GO:0051017 actin filament bundle assembly 12 4.19e-01 1.35e-01 0.787000
GO:0031167 rRNA methylation 11 4.40e-01 -1.34e-01 0.794000
GO:0003727 single-stranded RNA binding 21 2.87e-01 -1.34e-01 0.719000
GO:0006936 muscle contraction 12 4.21e-01 1.34e-01 0.787000
GO:0006368 transcription elongation by RNA polymerase II 24 2.55e-01 -1.34e-01 0.701000
GO:0006396 RNA processing 21 2.87e-01 -1.34e-01 0.719000
GO:0051219 phosphoprotein binding 20 2.99e-01 -1.34e-01 0.732000
GO:0035023 regulation of Rho protein signal transduction 16 3.54e-01 1.34e-01 0.770000
GO:0042254 ribosome biogenesis 16 3.56e-01 -1.33e-01 0.770000
GO:0035329 hippo signaling 18 3.29e-01 1.33e-01 0.755000
GO:0097009 energy homeostasis 22 2.82e-01 1.33e-01 0.718000
GO:0007229 integrin-mediated signaling pathway 44 1.30e-01 -1.32e-01 0.525000
GO:0051965 positive regulation of synapse assembly 23 2.74e-01 1.32e-01 0.712000
GO:0048568 embryonic organ development 14 3.94e-01 1.32e-01 0.784000
GO:0005544 calcium-dependent phospholipid binding 22 2.86e-01 1.31e-01 0.719000
GO:0034446 substrate adhesion-dependent cell spreading 35 1.79e-01 1.31e-01 0.610000
GO:0005680 anaphase-promoting complex 13 4.14e-01 -1.31e-01 0.785000
GO:0008253 5’-nucleotidase activity 10 4.73e-01 -1.31e-01 0.806000
GO:0060291 long-term synaptic potentiation 11 4.53e-01 1.31e-01 0.794000
GO:0032526 response to retinoic acid 15 3.81e-01 -1.31e-01 0.784000
GO:0018279 protein N-linked glycosylation via asparagine 11 4.53e-01 -1.31e-01 0.794000
GO:0019843 rRNA binding 22 2.89e-01 -1.31e-01 0.720000
GO:0030336 negative regulation of cell migration 51 1.07e-01 1.31e-01 0.487000
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 18 3.38e-01 1.31e-01 0.758000
GO:0061024 membrane organization 13 4.15e-01 -1.30e-01 0.786000
GO:0000082 G1/S transition of mitotic cell cycle 41 1.49e-01 -1.30e-01 0.551000
GO:0003887 DNA-directed DNA polymerase activity 16 3.67e-01 -1.30e-01 0.776000
GO:1903077 negative regulation of protein localization to plasma membrane 14 3.99e-01 -1.30e-01 0.784000
GO:0051537 2 iron, 2 sulfur cluster binding 17 3.53e-01 -1.30e-01 0.770000
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 77 4.88e-02 1.30e-01 0.356000
GO:0061564 axon development 13 4.18e-01 -1.30e-01 0.786000
GO:0046961 proton-transporting ATPase activity, rotational mechanism 14 4.01e-01 1.30e-01 0.784000
GO:0031334 positive regulation of protein-containing complex assembly 17 3.55e-01 1.30e-01 0.770000
GO:0060038 cardiac muscle cell proliferation 12 4.38e-01 -1.29e-01 0.794000
GO:0032211 negative regulation of telomere maintenance via telomerase 10 4.79e-01 -1.29e-01 0.806000
GO:0006906 vesicle fusion 15 3.86e-01 -1.29e-01 0.784000
GO:0005874 microtubule 131 1.08e-02 -1.29e-01 0.163000
GO:0004715 non-membrane spanning protein tyrosine kinase activity 21 3.07e-01 1.29e-01 0.738000
GO:0051402 neuron apoptotic process 42 1.50e-01 1.29e-01 0.553000
GO:0001750 photoreceptor outer segment 24 2.76e-01 1.29e-01 0.714000
GO:0051302 regulation of cell division 11 4.61e-01 -1.28e-01 0.797000
GO:0051496 positive regulation of stress fiber assembly 31 2.17e-01 1.28e-01 0.653000
GO:0060976 coronary vasculature development 18 3.47e-01 1.28e-01 0.766000
GO:0030141 secretory granule 20 3.21e-01 -1.28e-01 0.748000
GO:0090543 Flemming body 14 4.07e-01 -1.28e-01 0.784000
GO:0007286 spermatid development 25 2.69e-01 1.28e-01 0.708000
GO:0006986 response to unfolded protein 12 4.44e-01 1.28e-01 0.794000
GO:0005758 mitochondrial intermembrane space 47 1.32e-01 -1.27e-01 0.528000
GO:0046854 phosphatidylinositol phosphate biosynthetic process 18 3.51e-01 -1.27e-01 0.770000
GO:0043542 endothelial cell migration 14 4.11e-01 1.27e-01 0.784000
GO:0001569 branching involved in blood vessel morphogenesis 15 3.95e-01 -1.27e-01 0.784000
GO:0098656 monoatomic anion transmembrane transport 18 3.53e-01 1.27e-01 0.770000
GO:0006006 glucose metabolic process 26 2.64e-01 -1.26e-01 0.708000
GO:0141198 protein branched polyubiquitination 13 4.30e-01 1.26e-01 0.791000
GO:0060041 retina development in camera-type eye 22 3.05e-01 1.26e-01 0.738000
GO:0043235 receptor complex 79 5.34e-02 1.26e-01 0.366000
GO:0006334 nucleosome assembly 27 2.58e-01 -1.26e-01 0.701000
GO:0007507 heart development 80 5.33e-02 1.25e-01 0.366000
GO:0008076 voltage-gated potassium channel complex 24 2.89e-01 -1.25e-01 0.720000
GO:0005791 rough endoplasmic reticulum 12 4.54e-01 -1.25e-01 0.794000
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction 21 3.23e-01 1.25e-01 0.749000
GO:0031116 positive regulation of microtubule polymerization 11 4.74e-01 -1.25e-01 0.806000
GO:0030501 positive regulation of bone mineralization 13 4.37e-01 1.24e-01 0.794000
GO:0031594 neuromuscular junction 34 2.10e-01 -1.24e-01 0.648000
GO:0046983 protein dimerization activity 69 7.45e-02 1.24e-01 0.415000
GO:0060324 face development 13 4.39e-01 1.24e-01 0.794000
GO:0061157 mRNA destabilization 12 4.57e-01 1.24e-01 0.794000
GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 13 4.40e-01 1.24e-01 0.794000
GO:0035904 aorta development 15 4.07e-01 1.24e-01 0.784000
GO:0031624 ubiquitin conjugating enzyme binding 17 3.78e-01 -1.24e-01 0.784000
GO:1990841 promoter-specific chromatin binding 35 2.07e-01 1.23e-01 0.647000
GO:0031669 cellular response to nutrient levels 13 4.42e-01 1.23e-01 0.794000
GO:0000287 magnesium ion binding 151 9.25e-03 -1.23e-01 0.147000
GO:0006412 translation 96 3.80e-02 1.23e-01 0.325000
GO:0007416 synapse assembly 25 2.89e-01 -1.22e-01 0.720000
GO:0033344 cholesterol efflux 12 4.63e-01 1.22e-01 0.797000
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 12 4.63e-01 -1.22e-01 0.797000
GO:0140359 ABC-type transporter activity 11 4.82e-01 1.22e-01 0.806000
GO:0007265 Ras protein signal transduction 37 1.98e-01 1.22e-01 0.637000
GO:0015485 cholesterol binding 28 2.63e-01 1.22e-01 0.708000
GO:0072089 stem cell proliferation 22 3.22e-01 1.22e-01 0.749000
GO:0001501 skeletal system development 33 2.26e-01 1.22e-01 0.669000
GO:0032418 lysosome localization 23 3.13e-01 1.22e-01 0.740000
GO:0004864 protein phosphatase inhibitor activity 13 4.49e-01 -1.21e-01 0.794000
GO:0048041 focal adhesion assembly 14 4.32e-01 1.21e-01 0.793000
GO:0005506 iron ion binding 64 9.34e-02 -1.21e-01 0.454000
GO:0007519 skeletal muscle tissue development 16 4.01e-01 1.21e-01 0.784000
GO:0008198 ferrous iron binding 12 4.67e-01 -1.21e-01 0.800000
GO:0001778 plasma membrane repair 16 4.01e-01 -1.21e-01 0.784000
GO:0035269 protein O-linked mannosylation 13 4.49e-01 -1.21e-01 0.794000
GO:0070062 extracellular exosome 40 1.85e-01 -1.21e-01 0.617000
GO:0045931 positive regulation of mitotic cell cycle 14 4.33e-01 -1.21e-01 0.794000
GO:0030855 epithelial cell differentiation 28 2.69e-01 -1.21e-01 0.708000
GO:0031491 nucleosome binding 25 2.96e-01 -1.21e-01 0.727000
GO:0009888 tissue development 18 3.76e-01 -1.21e-01 0.784000
GO:0050770 regulation of axonogenesis 13 4.54e-01 1.20e-01 0.794000
GO:0005795 Golgi stack 19 3.66e-01 -1.20e-01 0.776000
GO:0006400 tRNA modification 11 4.92e-01 -1.20e-01 0.812000
GO:0010595 positive regulation of endothelial cell migration 26 2.91e-01 -1.20e-01 0.722000
GO:0033077 T cell differentiation in thymus 17 3.94e-01 1.19e-01 0.784000
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 42 1.81e-01 -1.19e-01 0.610000
GO:0009925 basal plasma membrane 12 4.74e-01 -1.19e-01 0.806000
GO:0045943 positive regulation of transcription by RNA polymerase I 11 4.93e-01 -1.19e-01 0.812000
GO:0050767 regulation of neurogenesis 14 4.40e-01 -1.19e-01 0.794000
GO:2000786 positive regulation of autophagosome assembly 14 4.41e-01 1.19e-01 0.794000
GO:0005694 chromosome 76 7.51e-02 -1.18e-01 0.415000
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 21 3.51e-01 -1.18e-01 0.770000
GO:0017148 negative regulation of translation 44 1.77e-01 -1.18e-01 0.610000
GO:0030552 cAMP binding 10 5.20e-01 1.18e-01 0.829000
GO:0008593 regulation of Notch signaling pathway 10 5.20e-01 1.17e-01 0.829000
GO:0001708 cell fate specification 12 4.81e-01 1.17e-01 0.806000
GO:0006096 glycolytic process 23 3.30e-01 -1.17e-01 0.755000
GO:0001678 intracellular glucose homeostasis 17 4.04e-01 1.17e-01 0.784000
GO:0007274 neuromuscular synaptic transmission 12 4.84e-01 -1.17e-01 0.806000
GO:0005884 actin filament 44 1.81e-01 -1.17e-01 0.610000
GO:2000737 negative regulation of stem cell differentiation 12 4.85e-01 1.16e-01 0.807000
GO:0032465 regulation of cytokinesis 23 3.34e-01 1.16e-01 0.758000
GO:0070534 protein K63-linked ubiquitination 31 2.63e-01 -1.16e-01 0.708000
GO:0046332 SMAD binding 23 3.36e-01 1.16e-01 0.758000
GO:0043014 alpha-tubulin binding 23 3.37e-01 1.16e-01 0.758000
GO:0032869 cellular response to insulin stimulus 34 2.44e-01 1.15e-01 0.697000
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 38 2.19e-01 1.15e-01 0.657000
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 114 3.36e-02 1.15e-01 0.308000
GO:2000045 regulation of G1/S transition of mitotic cell cycle 18 3.99e-01 1.15e-01 0.784000
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 12 4.92e-01 1.15e-01 0.812000
GO:0016042 lipid catabolic process 29 2.87e-01 -1.14e-01 0.719000
GO:0051260 protein homooligomerization 46 1.80e-01 -1.14e-01 0.610000
GO:0030509 BMP signaling pathway 37 2.29e-01 1.14e-01 0.673000
GO:0005879 axonemal microtubule 10 5.31e-01 -1.14e-01 0.832000
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 13 4.76e-01 1.14e-01 0.806000
GO:0007601 visual perception 37 2.30e-01 1.14e-01 0.673000
GO:0032024 positive regulation of insulin secretion 22 3.54e-01 1.14e-01 0.770000
GO:0004535 poly(A)-specific ribonuclease activity 10 5.33e-01 -1.14e-01 0.832000
GO:0004722 protein serine/threonine phosphatase activity 34 2.51e-01 -1.14e-01 0.698000
GO:0035019 somatic stem cell population maintenance 31 2.73e-01 1.14e-01 0.712000
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 15 4.46e-01 1.14e-01 0.794000
GO:0015914 phospholipid transport 25 3.26e-01 -1.13e-01 0.752000
GO:0008021 synaptic vesicle 47 1.79e-01 1.13e-01 0.610000
GO:0005385 zinc ion transmembrane transporter activity 15 4.48e-01 1.13e-01 0.794000
GO:0015297 antiporter activity 19 3.94e-01 1.13e-01 0.784000
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 158 1.44e-02 -1.13e-01 0.191000
GO:0048027 mRNA 5’-UTR binding 19 3.94e-01 -1.13e-01 0.784000
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 10 5.37e-01 -1.13e-01 0.834000
GO:0001974 blood vessel remodeling 16 4.35e-01 1.13e-01 0.794000
GO:0001650 fibrillar center 102 4.95e-02 -1.13e-01 0.356000
GO:0030496 midbody 99 5.31e-02 -1.13e-01 0.366000
GO:0017018 myosin phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0140791 histone H2AXS140 phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:1990439 MAP kinase serine/threonine phosphatase activity 13 4.83e-01 -1.12e-01 0.806000
GO:0006509 membrane protein ectodomain proteolysis 15 4.54e-01 1.12e-01 0.794000
GO:0008380 RNA splicing 47 1.85e-01 -1.12e-01 0.617000
GO:0045454 cell redox homeostasis 20 3.87e-01 -1.12e-01 0.784000
GO:0031466 Cul5-RING ubiquitin ligase complex 11 5.22e-01 1.12e-01 0.830000
GO:0002218 activation of innate immune response 17 4.26e-01 -1.12e-01 0.787000
GO:0099170 postsynaptic modulation of chemical synaptic transmission 12 5.04e-01 1.11e-01 0.824000
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 33 2.69e-01 -1.11e-01 0.708000
GO:0019905 syntaxin binding 25 3.36e-01 -1.11e-01 0.758000
GO:0005901 caveola 28 3.09e-01 1.11e-01 0.740000
GO:1905515 non-motile cilium assembly 39 2.33e-01 -1.10e-01 0.678000
GO:0042593 glucose homeostasis 42 2.17e-01 1.10e-01 0.653000
GO:0001541 ovarian follicle development 19 4.06e-01 -1.10e-01 0.784000
GO:0034614 cellular response to reactive oxygen species 16 4.47e-01 1.10e-01 0.794000
GO:0030031 cell projection assembly 10 5.48e-01 1.10e-01 0.847000
GO:0003148 outflow tract septum morphogenesis 11 5.30e-01 1.09e-01 0.832000
GO:0045335 phagocytic vesicle 36 2.56e-01 1.09e-01 0.701000
GO:0032993 protein-DNA complex 21 3.87e-01 -1.09e-01 0.784000
GO:0071222 cellular response to lipopolysaccharide 44 2.11e-01 -1.09e-01 0.648000
GO:0001675 acrosome assembly 11 5.32e-01 -1.09e-01 0.832000
GO:0070374 positive regulation of ERK1 and ERK2 cascade 62 1.40e-01 1.08e-01 0.530000
GO:0004197 cysteine-type endopeptidase activity 37 2.54e-01 1.08e-01 0.700000
GO:0046676 negative regulation of insulin secretion 11 5.34e-01 1.08e-01 0.832000
GO:0003785 actin monomer binding 14 4.83e-01 -1.08e-01 0.806000
GO:0048704 embryonic skeletal system morphogenesis 18 4.26e-01 1.08e-01 0.787000
GO:0005085 guanyl-nucleotide exchange factor activity 144 2.51e-02 1.08e-01 0.262000
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 26 3.40e-01 1.08e-01 0.759000
GO:0007029 endoplasmic reticulum organization 16 4.56e-01 1.08e-01 0.794000
GO:0001664 G protein-coupled receptor binding 23 3.73e-01 -1.07e-01 0.784000
GO:0005689 U12-type spliceosomal complex 20 4.07e-01 -1.07e-01 0.784000
GO:0006865 amino acid transport 10 5.58e-01 -1.07e-01 0.850000
GO:0014069 postsynaptic density 96 7.17e-02 1.06e-01 0.406000
GO:0001222 transcription corepressor binding 27 3.39e-01 1.06e-01 0.759000
GO:0004896 cytokine receptor activity 19 4.23e-01 1.06e-01 0.787000
GO:0003281 ventricular septum development 14 4.92e-01 1.06e-01 0.812000
GO:0035116 embryonic hindlimb morphogenesis 12 5.24e-01 1.06e-01 0.832000
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 14 4.93e-01 1.06e-01 0.812000
GO:0007517 muscle organ development 12 5.27e-01 -1.06e-01 0.832000
GO:0000245 spliceosomal complex assembly 10 5.64e-01 -1.06e-01 0.850000
GO:0030170 pyridoxal phosphate binding 34 2.87e-01 -1.05e-01 0.719000
GO:0001649 osteoblast differentiation 39 2.55e-01 1.05e-01 0.701000
GO:0005882 intermediate filament 21 4.04e-01 1.05e-01 0.784000
GO:0048706 embryonic skeletal system development 16 4.67e-01 -1.05e-01 0.800000
GO:0043539 protein serine/threonine kinase activator activity 33 2.97e-01 -1.05e-01 0.728000
GO:0034394 protein localization to cell surface 17 4.55e-01 -1.05e-01 0.794000
GO:0035082 axoneme assembly 10 5.68e-01 1.04e-01 0.851000
GO:0017124 SH3 domain binding 43 2.37e-01 -1.04e-01 0.686000
GO:0048538 thymus development 21 4.09e-01 1.04e-01 0.784000
GO:0016887 ATP hydrolysis activity 217 8.45e-03 -1.04e-01 0.135000
GO:0005112 Notch binding 13 5.17e-01 -1.04e-01 0.829000
GO:0000398 mRNA splicing, via spliceosome 87 9.44e-02 -1.04e-01 0.456000
GO:0009792 embryo development ending in birth or egg hatching 10 5.71e-01 1.04e-01 0.851000
GO:0007219 Notch signaling pathway 42 2.46e-01 1.03e-01 0.697000
GO:0016514 SWI/SNF complex 20 4.24e-01 -1.03e-01 0.787000
GO:0008266 poly(U) RNA binding 16 4.76e-01 -1.03e-01 0.806000
GO:0004521 RNA endonuclease activity 20 4.26e-01 1.03e-01 0.787000
GO:0045332 phospholipid translocation 16 4.77e-01 1.03e-01 0.806000
GO:0005576 extracellular region 245 5.85e-03 1.03e-01 0.104000
GO:0043679 axon terminus 17 4.65e-01 1.02e-01 0.797000
GO:0003723 RNA binding 372 7.24e-04 -1.02e-01 0.030300
GO:0019903 protein phosphatase binding 49 2.17e-01 1.02e-01 0.653000
GO:0050727 regulation of inflammatory response 27 3.59e-01 1.02e-01 0.770000
GO:0019882 antigen processing and presentation 11 5.60e-01 -1.02e-01 0.850000
GO:0036503 ERAD pathway 59 1.78e-01 -1.02e-01 0.610000
GO:0016787 hydrolase activity 108 6.87e-02 -1.02e-01 0.402000
GO:0051603 proteolysis involved in protein catabolic process 23 4.00e-01 -1.01e-01 0.784000
GO:0005741 mitochondrial outer membrane 96 8.63e-02 -1.01e-01 0.440000
GO:0010975 regulation of neuron projection development 16 4.83e-01 -1.01e-01 0.806000
GO:0034142 toll-like receptor 4 signaling pathway 14 5.12e-01 1.01e-01 0.829000
GO:0000228 nuclear chromosome 13 5.28e-01 -1.01e-01 0.832000
GO:2000352 negative regulation of endothelial cell apoptotic process 14 5.14e-01 1.01e-01 0.829000
GO:0001530 lipopolysaccharide binding 11 5.65e-01 -1.00e-01 0.850000
GO:0005540 hyaluronic acid binding 13 5.31e-01 1.00e-01 0.832000
GO:0045747 positive regulation of Notch signaling pathway 23 4.05e-01 1.00e-01 0.784000
GO:0060349 bone morphogenesis 11 5.65e-01 1.00e-01 0.851000
GO:0035401 histone H3Y41 kinase activity 23 4.06e-01 1.00e-01 0.784000
GO:0045171 intercellular bridge 56 1.97e-01 -9.98e-02 0.636000
GO:0000407 phagophore assembly site 20 4.40e-01 -9.97e-02 0.794000
GO:1901379 regulation of potassium ion transmembrane transport 10 5.85e-01 -9.96e-02 0.861000
GO:0031252 cell leading edge 19 4.53e-01 -9.95e-02 0.794000
GO:0003700 DNA-binding transcription factor activity 79 1.27e-01 9.95e-02 0.522000
GO:0048705 skeletal system morphogenesis 15 5.06e-01 9.92e-02 0.824000
GO:0090110 COPII-coated vesicle cargo loading 10 5.87e-01 -9.92e-02 0.861000
GO:0042995 cell projection 54 2.08e-01 9.90e-02 0.648000
GO:0004386 helicase activity 40 2.79e-01 9.89e-02 0.715000
GO:0019706 protein-cysteine S-palmitoyltransferase activity 17 4.82e-01 -9.84e-02 0.806000
GO:0061512 protein localization to cilium 22 4.25e-01 -9.82e-02 0.787000
GO:0045296 cadherin binding 31 3.44e-01 9.82e-02 0.765000
GO:0005769 early endosome 139 4.61e-02 9.81e-02 0.353000
GO:2000377 regulation of reactive oxygen species metabolic process 10 5.92e-01 -9.79e-02 0.866000
GO:0030155 regulation of cell adhesion 19 4.61e-01 9.76e-02 0.797000
GO:0007160 cell-matrix adhesion 40 2.86e-01 -9.76e-02 0.719000
GO:0120162 positive regulation of cold-induced thermogenesis 30 3.56e-01 9.75e-02 0.770000
GO:0000922 spindle pole 69 1.62e-01 -9.75e-02 0.583000
GO:0045453 bone resorption 12 5.59e-01 9.75e-02 0.850000
GO:0038084 vascular endothelial growth factor signaling pathway 24 4.09e-01 9.75e-02 0.784000
GO:0005604 basement membrane 45 2.58e-01 9.74e-02 0.701000
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 30 3.56e-01 9.74e-02 0.770000
GO:0000070 mitotic sister chromatid segregation 18 4.77e-01 -9.69e-02 0.806000
GO:0032012 regulation of ARF protein signal transduction 14 5.31e-01 9.68e-02 0.832000
GO:0042605 peptide antigen binding 10 5.96e-01 -9.67e-02 0.866000
GO:0005840 ribosome 43 2.74e-01 9.65e-02 0.712000
GO:0051536 iron-sulfur cluster binding 12 5.63e-01 -9.65e-02 0.850000
GO:0005080 protein kinase C binding 17 4.92e-01 -9.63e-02 0.812000
GO:0006303 double-strand break repair via nonhomologous end joining 20 4.56e-01 -9.63e-02 0.794000
GO:0061709 reticulophagy 15 5.19e-01 9.62e-02 0.829000
GO:0000421 autophagosome membrane 23 4.25e-01 9.62e-02 0.787000
GO:0140801 histone H2AXY142 kinase activity 24 4.15e-01 9.61e-02 0.786000
GO:0005102 signaling receptor binding 83 1.31e-01 -9.61e-02 0.526000
GO:0005164 tumor necrosis factor receptor binding 13 5.49e-01 9.60e-02 0.847000
GO:0090303 positive regulation of wound healing 11 5.82e-01 -9.59e-02 0.861000
GO:1900181 negative regulation of protein localization to nucleus 11 5.82e-01 -9.59e-02 0.861000
GO:0019899 enzyme binding 110 8.31e-02 -9.58e-02 0.434000
GO:0034497 protein localization to phagophore assembly site 11 5.83e-01 9.57e-02 0.861000
GO:0042177 negative regulation of protein catabolic process 24 4.18e-01 -9.56e-02 0.786000
GO:0006631 fatty acid metabolic process 34 3.36e-01 9.54e-02 0.758000
GO:0097191 extrinsic apoptotic signaling pathway 20 4.61e-01 -9.53e-02 0.797000
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 45 2.69e-01 9.53e-02 0.708000
GO:0043130 ubiquitin binding 61 1.98e-01 -9.53e-02 0.637000
GO:0045814 negative regulation of gene expression, epigenetic 16 5.10e-01 9.52e-02 0.829000
GO:0036464 cytoplasmic ribonucleoprotein granule 36 3.23e-01 9.52e-02 0.749000
GO:0006914 autophagy 44 2.75e-01 -9.52e-02 0.713000
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization 12 5.69e-01 -9.50e-02 0.851000
GO:0045665 negative regulation of neuron differentiation 25 4.11e-01 -9.50e-02 0.784000
GO:0034113 heterotypic cell-cell adhesion 11 5.87e-01 9.47e-02 0.861000
GO:0007204 positive regulation of cytosolic calcium ion concentration 20 4.64e-01 9.47e-02 0.797000
GO:0045880 positive regulation of smoothened signaling pathway 23 4.32e-01 -9.46e-02 0.793000
GO:0045740 positive regulation of DNA replication 11 5.87e-01 9.46e-02 0.861000
GO:0008089 anterograde axonal transport 10 6.05e-01 9.44e-02 0.867000
GO:1904115 axon cytoplasm 25 4.17e-01 9.39e-02 0.786000
GO:0006695 cholesterol biosynthetic process 16 5.16e-01 -9.39e-02 0.829000
GO:0005902 microvillus 29 3.82e-01 9.38e-02 0.784000
GO:0010506 regulation of autophagy 26 4.09e-01 9.35e-02 0.784000
GO:0071005 U2-type precatalytic spliceosome 31 3.68e-01 -9.34e-02 0.778000
GO:0030968 endoplasmic reticulum unfolded protein response 30 3.76e-01 -9.34e-02 0.784000
GO:0001525 angiogenesis 86 1.36e-01 9.32e-02 0.530000
GO:0043488 regulation of mRNA stability 16 5.19e-01 9.31e-02 0.829000
GO:0070527 platelet aggregation 16 5.20e-01 -9.29e-02 0.829000
GO:0019915 lipid storage 11 5.94e-01 9.29e-02 0.866000
GO:0016791 phosphatase activity 15 5.34e-01 9.28e-02 0.832000
GO:0002053 positive regulation of mesenchymal cell proliferation 10 6.12e-01 -9.27e-02 0.867000
GO:0050728 negative regulation of inflammatory response 49 2.66e-01 9.19e-02 0.708000
GO:0051117 ATPase binding 44 2.92e-01 -9.19e-02 0.722000
GO:0001666 response to hypoxia 51 2.57e-01 -9.18e-02 0.701000
GO:0031145 anaphase-promoting complex-dependent catabolic process 14 5.53e-01 -9.16e-02 0.847000
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 13 5.68e-01 9.15e-02 0.851000
GO:0005977 glycogen metabolic process 13 5.68e-01 -9.14e-02 0.851000
GO:0007010 cytoskeleton organization 51 2.59e-01 -9.14e-02 0.701000
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 12 5.84e-01 9.14e-02 0.861000
GO:0008584 male gonad development 27 4.11e-01 9.14e-02 0.784000
GO:0005615 extracellular space 402 1.77e-03 9.13e-02 0.051500
GO:0046513 ceramide biosynthetic process 19 4.91e-01 -9.12e-02 0.812000
GO:0045216 cell-cell junction organization 13 5.70e-01 9.10e-02 0.851000
GO:0032755 positive regulation of interleukin-6 production 31 3.82e-01 -9.08e-02 0.784000
GO:0042056 chemoattractant activity 11 6.02e-01 -9.07e-02 0.866000
GO:0001558 regulation of cell growth 24 4.42e-01 -9.07e-02 0.794000
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 26 4.25e-01 -9.05e-02 0.787000
GO:0031941 filamentous actin 19 4.96e-01 9.03e-02 0.812000
GO:0034314 Arp2/3 complex-mediated actin nucleation 11 6.04e-01 9.03e-02 0.866000
GO:0097431 mitotic spindle pole 27 4.17e-01 -9.02e-02 0.786000
GO:0055038 recycling endosome membrane 43 3.07e-01 -9.01e-02 0.738000
GO:0010508 positive regulation of autophagy 39 3.31e-01 9.01e-02 0.755000
GO:0006606 protein import into nucleus 62 2.20e-01 -9.00e-02 0.660000
GO:0090307 mitotic spindle assembly 30 3.96e-01 -8.96e-02 0.784000
GO:0032868 response to insulin 22 4.67e-01 8.95e-02 0.800000
GO:0008327 methyl-CpG binding 16 5.36e-01 8.94e-02 0.834000
GO:0030175 filopodium 30 3.98e-01 -8.93e-02 0.784000
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 18 5.12e-01 -8.93e-02 0.829000
GO:0009966 regulation of signal transduction 39 3.36e-01 -8.91e-02 0.758000
GO:0015629 actin cytoskeleton 114 1.01e-01 -8.91e-02 0.473000
GO:0003333 amino acid transmembrane transport 10 6.26e-01 8.89e-02 0.873000
GO:0042826 histone deacetylase binding 66 2.12e-01 -8.89e-02 0.648000
GO:0000139 Golgi membrane 265 1.30e-02 -8.89e-02 0.181000
GO:0009267 cellular response to starvation 48 2.87e-01 8.88e-02 0.719000
GO:0005635 nuclear envelope 77 1.78e-01 -8.88e-02 0.610000
GO:0035267 NuA4 histone acetyltransferase complex 18 5.15e-01 8.88e-02 0.829000
GO:0030307 positive regulation of cell growth 36 3.58e-01 -8.85e-02 0.770000
GO:0031526 brush border membrane 12 5.95e-01 -8.85e-02 0.866000
GO:0045669 positive regulation of osteoblast differentiation 37 3.52e-01 8.85e-02 0.770000
GO:0051123 RNA polymerase II preinitiation complex assembly 16 5.42e-01 8.82e-02 0.841000
GO:0005764 lysosome 133 7.98e-02 -8.81e-02 0.424000
GO:0005905 clathrin-coated pit 30 4.06e-01 8.76e-02 0.784000
GO:0061631 ubiquitin conjugating enzyme activity 24 4.58e-01 -8.75e-02 0.794000
GO:0030139 endocytic vesicle 38 3.51e-01 8.74e-02 0.770000
GO:0000381 regulation of alternative mRNA splicing, via spliceosome 31 4.00e-01 -8.74e-02 0.784000
GO:0034644 cellular response to UV 32 3.93e-01 -8.74e-02 0.784000
GO:0030217 T cell differentiation 18 5.22e-01 8.72e-02 0.830000
GO:0000307 cyclin-dependent protein kinase holoenzyme complex 20 5.00e-01 8.72e-02 0.818000
GO:0007186 G protein-coupled receptor signaling pathway 92 1.49e-01 8.72e-02 0.551000
GO:0016605 PML body 61 2.41e-01 -8.69e-02 0.690000
GO:0032874 positive regulation of stress-activated MAPK cascade 11 6.18e-01 8.69e-02 0.870000
GO:0040014 regulation of multicellular organism growth 12 6.03e-01 8.68e-02 0.866000
GO:0030145 manganese ion binding 45 3.15e-01 -8.66e-02 0.742000
GO:0006346 DNA methylation-dependent constitutive heterochromatin formation 10 6.36e-01 -8.65e-02 0.877000
GO:0140693 molecular condensate scaffold activity 24 4.63e-01 -8.65e-02 0.797000
GO:0001618 virus receptor activity 10 6.36e-01 8.65e-02 0.877000
GO:0070971 endoplasmic reticulum exit site 19 5.14e-01 8.64e-02 0.829000
GO:0031124 mRNA 3’-end processing 13 5.90e-01 8.64e-02 0.864000
GO:0045599 negative regulation of fat cell differentiation 19 5.14e-01 8.64e-02 0.829000
GO:0042273 ribosomal large subunit biogenesis 22 4.84e-01 -8.63e-02 0.806000
GO:0005789 endoplasmic reticulum membrane 408 2.91e-03 -8.63e-02 0.065400
GO:0005254 chloride channel activity 19 5.15e-01 8.62e-02 0.829000
GO:0035987 endodermal cell differentiation 21 4.94e-01 8.62e-02 0.812000
GO:0046856 phosphatidylinositol dephosphorylation 26 4.47e-01 -8.61e-02 0.794000
GO:0030127 COPII vesicle coat 10 6.37e-01 -8.61e-02 0.877000
GO:0007098 centrosome cycle 17 5.40e-01 -8.60e-02 0.838000
GO:0032585 multivesicular body membrane 12 6.06e-01 -8.59e-02 0.867000
GO:0036064 ciliary basal body 103 1.33e-01 -8.59e-02 0.529000
GO:0097150 neuronal stem cell population maintenance 18 5.29e-01 8.57e-02 0.832000
GO:0006886 intracellular protein transport 163 5.96e-02 -8.57e-02 0.384000
GO:0051290 protein heterotetramerization 10 6.40e-01 -8.55e-02 0.877000
GO:0005249 voltage-gated potassium channel activity 16 5.54e-01 -8.55e-02 0.848000
GO:0070006 metalloaminopeptidase activity 15 5.68e-01 8.51e-02 0.851000
GO:0007259 cell surface receptor signaling pathway via JAK-STAT 22 4.90e-01 8.51e-02 0.812000
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 347 6.72e-03 8.50e-02 0.116000
GO:0048675 axon extension 20 5.11e-01 8.50e-02 0.829000
GO:2000042 negative regulation of double-strand break repair via homologous recombination 16 5.57e-01 -8.48e-02 0.850000
GO:0043525 positive regulation of neuron apoptotic process 18 5.34e-01 8.47e-02 0.832000
GO:0006357 regulation of transcription by RNA polymerase II 548 7.62e-04 8.46e-02 0.030800
GO:0033192 calmodulin-dependent protein phosphatase activity 16 5.59e-01 -8.44e-02 0.850000
GO:0035064 methylated histone binding 42 3.45e-01 -8.43e-02 0.765000
GO:0000165 MAPK cascade 47 3.19e-01 8.41e-02 0.747000
GO:0003725 double-stranded RNA binding 44 3.35e-01 -8.41e-02 0.758000
GO:0051865 protein autoubiquitination 40 3.58e-01 -8.40e-02 0.770000
GO:0070273 phosphatidylinositol-4-phosphate binding 17 5.51e-01 -8.36e-02 0.847000
GO:0030672 synaptic vesicle membrane 44 3.38e-01 -8.36e-02 0.758000
GO:0042470 melanosome 28 4.44e-01 -8.36e-02 0.794000
GO:0030136 clathrin-coated vesicle 29 4.38e-01 8.33e-02 0.794000
GO:0031410 cytoplasmic vesicle 107 1.38e-01 8.32e-02 0.530000
GO:0005200 structural constituent of cytoskeleton 28 4.47e-01 -8.31e-02 0.794000
GO:0005515 protein binding 90 1.76e-01 -8.27e-02 0.610000
GO:0002682 regulation of immune system process 10 6.52e-01 8.25e-02 0.885000
GO:0010494 cytoplasmic stress granule 58 2.78e-01 -8.24e-02 0.715000
GO:0071356 cellular response to tumor necrosis factor 37 3.87e-01 -8.22e-02 0.784000
GO:0106310 protein serine kinase activity 38 3.83e-01 8.18e-02 0.784000
GO:0006644 phospholipid metabolic process 11 6.39e-01 8.18e-02 0.877000
GO:0098793 presynapse 64 2.58e-01 -8.18e-02 0.701000
GO:0006402 mRNA catabolic process 14 5.97e-01 8.16e-02 0.866000
GO:0019955 cytokine binding 13 6.11e-01 8.14e-02 0.867000
GO:0001540 amyloid-beta binding 28 4.56e-01 -8.14e-02 0.794000
GO:0000724 double-strand break repair via homologous recombination 71 2.38e-01 -8.11e-02 0.686000
GO:0006623 protein targeting to vacuole 11 6.41e-01 8.11e-02 0.877000
GO:0050766 positive regulation of phagocytosis 14 6.00e-01 -8.10e-02 0.866000
GO:0060379 cardiac muscle cell myoblast differentiation 10 6.59e-01 -8.06e-02 0.886000
GO:0016491 oxidoreductase activity 48 3.35e-01 8.05e-02 0.758000
GO:0060021 roof of mouth development 35 4.12e-01 8.02e-02 0.784000
GO:0042100 B cell proliferation 14 6.04e-01 8.02e-02 0.866000
GO:0031965 nuclear membrane 120 1.30e-01 -8.02e-02 0.525000
GO:0070412 R-SMAD binding 13 6.18e-01 -7.99e-02 0.870000
GO:0015031 protein transport 174 6.97e-02 -7.99e-02 0.403000
GO:0044322 endoplasmic reticulum quality control compartment 11 6.47e-01 7.97e-02 0.881000
GO:0005765 lysosomal membrane 138 1.09e-01 7.93e-02 0.488000
GO:0030904 retromer complex 15 5.96e-01 -7.92e-02 0.866000
GO:0005819 spindle 54 3.15e-01 -7.92e-02 0.742000
GO:0043531 ADP binding 21 5.30e-01 -7.91e-02 0.832000
GO:0016829 lyase activity 15 5.97e-01 -7.89e-02 0.866000
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 15 5.97e-01 -7.88e-02 0.866000
GO:0007131 reciprocal meiotic recombination 12 6.37e-01 -7.88e-02 0.877000
GO:2000773 negative regulation of cellular senescence 12 6.37e-01 7.86e-02 0.877000
GO:0046907 intracellular transport 14 6.11e-01 -7.86e-02 0.867000
GO:0022008 neurogenesis 31 4.50e-01 7.85e-02 0.794000
GO:0019722 calcium-mediated signaling 32 4.43e-01 7.84e-02 0.794000
GO:0031982 vesicle 26 4.89e-01 7.83e-02 0.812000
GO:0030133 transport vesicle 22 5.25e-01 -7.82e-02 0.832000
GO:0032456 endocytic recycling 42 3.83e-01 7.78e-02 0.784000
GO:0045595 regulation of cell differentiation 13 6.28e-01 7.76e-02 0.874000
GO:0033627 cell adhesion mediated by integrin 22 5.29e-01 -7.75e-02 0.832000
GO:1990573 potassium ion import across plasma membrane 18 5.69e-01 -7.75e-02 0.851000
GO:0006417 regulation of translation 44 3.75e-01 -7.74e-02 0.784000
GO:0038023 signaling receptor activity 40 3.98e-01 7.73e-02 0.784000
GO:0004252 serine-type endopeptidase activity 51 3.41e-01 -7.71e-02 0.759000
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 10 6.74e-01 -7.69e-02 0.891000
GO:0007099 centriole replication 13 6.32e-01 7.68e-02 0.877000
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 19 5.62e-01 7.68e-02 0.850000
GO:0006979 response to oxidative stress 49 3.53e-01 -7.68e-02 0.770000
GO:0060170 ciliary membrane 20 5.52e-01 -7.67e-02 0.847000
GO:0000987 cis-regulatory region sequence-specific DNA binding 21 5.43e-01 7.67e-02 0.842000
GO:0000976 transcription cis-regulatory region binding 55 3.25e-01 -7.67e-02 0.752000
GO:0097190 apoptotic signaling pathway 20 5.55e-01 -7.62e-02 0.849000
GO:0098686 hippocampal mossy fiber to CA3 synapse 16 5.98e-01 -7.62e-02 0.866000
GO:0019003 GDP binding 44 3.82e-01 -7.61e-02 0.784000
GO:0050673 epithelial cell proliferation 20 5.56e-01 7.61e-02 0.849000
GO:0032420 stereocilium 14 6.22e-01 -7.60e-02 0.872000
GO:0001764 neuron migration 40 4.06e-01 7.59e-02 0.784000
GO:0086091 regulation of heart rate by cardiac conduction 21 5.47e-01 7.59e-02 0.846000
GO:0006605 protein targeting 18 5.78e-01 7.58e-02 0.858000
GO:0030833 regulation of actin filament polymerization 21 5.50e-01 7.54e-02 0.847000
GO:0008654 phospholipid biosynthetic process 12 6.52e-01 -7.52e-02 0.885000
GO:0006261 DNA-templated DNA replication 18 5.81e-01 -7.51e-02 0.861000
GO:0034045 phagophore assembly site membrane 12 6.53e-01 7.49e-02 0.885000
GO:0034976 response to endoplasmic reticulum stress 33 4.57e-01 -7.48e-02 0.794000
GO:0051209 release of sequestered calcium ion into cytosol 20 5.63e-01 7.47e-02 0.850000
GO:0009897 external side of plasma membrane 108 1.81e-01 7.46e-02 0.610000
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 12 6.55e-01 7.45e-02 0.886000
GO:0008233 peptidase activity 10 6.84e-01 7.44e-02 0.895000
GO:0006893 Golgi to plasma membrane transport 19 5.75e-01 -7.42e-02 0.857000
GO:0035331 negative regulation of hippo signaling 18 5.86e-01 -7.42e-02 0.861000
GO:0016358 dendrite development 19 5.78e-01 7.37e-02 0.858000
GO:0046716 muscle cell cellular homeostasis 15 6.21e-01 -7.37e-02 0.872000
GO:0050830 defense response to Gram-positive bacterium 15 6.22e-01 -7.35e-02 0.872000
GO:0070498 interleukin-1-mediated signaling pathway 11 6.73e-01 -7.34e-02 0.891000
GO:0090141 positive regulation of mitochondrial fission 16 6.11e-01 7.34e-02 0.867000
GO:0045600 positive regulation of fat cell differentiation 22 5.52e-01 7.33e-02 0.847000
GO:0071560 cellular response to transforming growth factor beta stimulus 16 6.14e-01 -7.29e-02 0.868000
GO:0004693 cyclin-dependent protein serine/threonine kinase activity 10 6.90e-01 -7.28e-02 0.895000
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 392 1.39e-02 7.27e-02 0.187000
GO:0007020 microtubule nucleation 14 6.38e-01 -7.26e-02 0.877000
GO:0060612 adipose tissue development 23 5.47e-01 7.26e-02 0.846000
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 181 9.34e-02 7.25e-02 0.454000
GO:0071526 semaphorin-plexin signaling pathway 25 5.31e-01 7.25e-02 0.832000
GO:0050840 extracellular matrix binding 17 6.05e-01 7.24e-02 0.867000
GO:0070840 dynein complex binding 12 6.66e-01 7.21e-02 0.887000
GO:0070050 neuron cellular homeostasis 14 6.41e-01 -7.20e-02 0.877000
GO:1903078 positive regulation of protein localization to plasma membrane 22 5.61e-01 -7.17e-02 0.850000
GO:0016197 endosomal transport 27 5.19e-01 7.16e-02 0.829000
GO:0048854 brain morphogenesis 14 6.43e-01 -7.16e-02 0.877000
GO:0060047 heart contraction 10 6.95e-01 -7.16e-02 0.898000
GO:0030335 positive regulation of cell migration 110 1.95e-01 7.16e-02 0.634000
GO:0031514 motile cilium 39 4.42e-01 7.12e-02 0.794000
GO:0001784 phosphotyrosine residue binding 27 5.23e-01 7.11e-02 0.831000
GO:0010467 gene expression 81 2.70e-01 7.10e-02 0.708000
GO:0005666 RNA polymerase III complex 12 6.70e-01 -7.10e-02 0.891000
GO:0002040 sprouting angiogenesis 18 6.02e-01 7.10e-02 0.866000
GO:0005938 cell cortex 74 2.94e-01 7.07e-02 0.723000
GO:1903543 positive regulation of exosomal secretion 10 6.99e-01 7.06e-02 0.899000
GO:0045773 positive regulation of axon extension 12 6.72e-01 -7.06e-02 0.891000
GO:0048306 calcium-dependent protein binding 20 5.86e-01 7.03e-02 0.861000
GO:0031625 ubiquitin protein ligase binding 173 1.11e-01 -7.03e-02 0.495000
GO:0001726 ruffle 43 4.26e-01 -7.03e-02 0.787000
GO:0034702 monoatomic ion channel complex 10 7.01e-01 7.02e-02 0.899000
GO:0030332 cyclin binding 20 5.87e-01 -7.01e-02 0.861000
GO:0035115 embryonic forelimb morphogenesis 16 6.28e-01 7.00e-02 0.874000
GO:0030674 protein-macromolecule adaptor activity 73 3.02e-01 -6.99e-02 0.734000
GO:0009887 animal organ morphogenesis 34 4.81e-01 -6.99e-02 0.806000
GO:0043536 positive regulation of blood vessel endothelial cell migration 18 6.08e-01 6.98e-02 0.867000
GO:0008270 zinc ion binding 401 1.71e-02 6.97e-02 0.207000
GO:0022857 transmembrane transporter activity 41 4.41e-01 -6.96e-02 0.794000
GO:0004672 protein kinase activity 64 3.37e-01 6.94e-02 0.758000
GO:0008217 regulation of blood pressure 20 5.92e-01 -6.93e-02 0.866000
GO:0042552 myelination 28 5.27e-01 6.91e-02 0.832000
GO:0042391 regulation of membrane potential 13 6.66e-01 6.91e-02 0.887000
GO:0032729 positive regulation of type II interferon production 21 5.86e-01 -6.86e-02 0.861000
GO:0000124 SAGA complex 15 6.46e-01 -6.86e-02 0.879000
GO:0030054 cell junction 52 3.94e-01 -6.83e-02 0.784000
GO:0014032 neural crest cell development 11 6.96e-01 -6.80e-02 0.898000
GO:0014704 intercalated disc 14 6.60e-01 -6.80e-02 0.886000
GO:0042632 cholesterol homeostasis 39 4.63e-01 6.79e-02 0.797000
GO:0007399 nervous system development 89 2.71e-01 6.75e-02 0.708000
GO:0005776 autophagosome 41 4.54e-01 6.75e-02 0.794000
GO:0044344 cellular response to fibroblast growth factor stimulus 10 7.12e-01 6.74e-02 0.904000
GO:0010629 negative regulation of gene expression 101 2.43e-01 6.73e-02 0.696000
GO:0010592 positive regulation of lamellipodium assembly 10 7.13e-01 6.73e-02 0.904000
GO:0005829 cytosol 2020 1.17e-06 -6.72e-02 0.000521
GO:0030425 dendrite 134 1.81e-01 6.70e-02 0.610000
GO:0035725 sodium ion transmembrane transport 43 4.48e-01 6.69e-02 0.794000
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 12 6.88e-01 6.69e-02 0.895000
GO:0004222 metalloendopeptidase activity 50 4.13e-01 6.69e-02 0.785000
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 10 7.15e-01 -6.66e-02 0.904000
GO:0016973 poly(A)+ mRNA export from nucleus 13 6.78e-01 -6.66e-02 0.893000
GO:0055037 recycling endosome 55 3.95e-01 -6.63e-02 0.784000
GO:0042981 regulation of apoptotic process 55 3.96e-01 -6.63e-02 0.784000
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 21 6.00e-01 6.62e-02 0.866000
GO:0044325 transmembrane transporter binding 57 3.89e-01 -6.60e-02 0.784000
GO:0048013 ephrin receptor signaling pathway 25 5.71e-01 -6.55e-02 0.851000
GO:0007626 locomotory behavior 27 5.56e-01 6.55e-02 0.849000
GO:0003729 mRNA binding 145 1.77e-01 -6.51e-02 0.610000
GO:0071108 protein K48-linked deubiquitination 15 6.63e-01 6.51e-02 0.886000
GO:0042147 retrograde transport, endosome to Golgi 50 4.28e-01 -6.49e-02 0.788000
GO:0042802 identical protein binding 663 4.70e-03 -6.49e-02 0.090600
GO:0000077 DNA damage checkpoint signaling 26 5.67e-01 6.49e-02 0.851000
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 19 6.26e-01 6.47e-02 0.873000
GO:0016601 Rac protein signal transduction 17 6.46e-01 -6.44e-02 0.879000
GO:0045732 positive regulation of protein catabolic process 46 4.50e-01 6.44e-02 0.794000
GO:0043197 dendritic spine 47 4.47e-01 -6.42e-02 0.794000
GO:0030165 PDZ domain binding 30 5.44e-01 6.41e-02 0.842000
GO:0042734 presynaptic membrane 35 5.12e-01 6.40e-02 0.829000
GO:0016779 nucleotidyltransferase activity 11 7.13e-01 -6.40e-02 0.904000
GO:0071364 cellular response to epidermal growth factor stimulus 19 6.29e-01 -6.40e-02 0.875000
GO:0008340 determination of adult lifespan 21 6.12e-01 -6.39e-02 0.867000
GO:0030316 osteoclast differentiation 29 5.52e-01 6.38e-02 0.847000
GO:0030488 tRNA methylation 20 6.22e-01 -6.37e-02 0.872000
GO:0016301 kinase activity 14 6.80e-01 -6.36e-02 0.894000
GO:0045995 regulation of embryonic development 27 5.67e-01 -6.36e-02 0.851000
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex 11 7.15e-01 -6.36e-02 0.904000
GO:0007369 gastrulation 10 7.28e-01 -6.36e-02 0.910000
GO:0061351 neural precursor cell proliferation 15 6.72e-01 -6.31e-02 0.891000
GO:0035591 signaling adaptor activity 40 4.90e-01 -6.31e-02 0.812000
GO:0005682 U5 snRNP 10 7.31e-01 6.28e-02 0.910000
GO:0005654 nucleoplasm 1529 6.18e-05 -6.25e-02 0.015700
GO:0044877 protein-containing complex binding 106 2.68e-01 -6.23e-02 0.708000
GO:0005669 transcription factor TFIID complex 22 6.13e-01 -6.23e-02 0.868000
GO:0004674 protein serine/threonine kinase activity 204 1.26e-01 6.22e-02 0.522000
GO:0071480 cellular response to gamma radiation 14 6.87e-01 6.22e-02 0.895000
GO:0030234 enzyme regulator activity 15 6.77e-01 -6.22e-02 0.892000
GO:0034063 stress granule assembly 20 6.31e-01 -6.21e-02 0.876000
GO:0030073 insulin secretion 13 6.98e-01 -6.21e-02 0.899000
GO:0006302 double-strand break repair 45 4.72e-01 -6.20e-02 0.806000
GO:0015035 protein-disulfide reductase activity 14 6.89e-01 -6.18e-02 0.895000
GO:0005975 carbohydrate metabolic process 49 4.54e-01 6.18e-02 0.794000
GO:0045815 transcription initiation-coupled chromatin remodeling 20 6.33e-01 -6.17e-02 0.877000
GO:0048471 perinuclear region of cytoplasm 289 7.25e-02 -6.16e-02 0.409000
GO:0048487 beta-tubulin binding 22 6.17e-01 6.16e-02 0.870000
GO:0030890 positive regulation of B cell proliferation 21 6.26e-01 6.15e-02 0.873000
GO:0051560 mitochondrial calcium ion homeostasis 13 7.03e-01 6.11e-02 0.900000
GO:0050829 defense response to Gram-negative bacterium 11 7.26e-01 -6.10e-02 0.910000
GO:0048786 presynaptic active zone 10 7.38e-01 6.10e-02 0.913000
GO:0010628 positive regulation of gene expression 147 2.02e-01 6.10e-02 0.640000
GO:0016446 somatic hypermutation of immunoglobulin genes 10 7.38e-01 -6.10e-02 0.913000
GO:0036158 outer dynein arm assembly 10 7.39e-01 6.09e-02 0.913000
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 20 6.38e-01 6.09e-02 0.877000
GO:0022604 regulation of cell morphogenesis 14 6.96e-01 6.04e-02 0.898000
GO:0030864 cortical actin cytoskeleton 31 5.61e-01 -6.04e-02 0.850000
GO:0007254 JNK cascade 25 6.01e-01 6.04e-02 0.866000
GO:0001046 core promoter sequence-specific DNA binding 11 7.29e-01 -6.03e-02 0.910000
GO:0008083 growth factor activity 41 5.05e-01 -6.02e-02 0.824000
GO:0008045 motor neuron axon guidance 12 7.19e-01 -6.01e-02 0.906000
GO:0005507 copper ion binding 23 6.18e-01 6.00e-02 0.870000
GO:0008203 cholesterol metabolic process 29 5.76e-01 -6.00e-02 0.857000
GO:0017025 TBP-class protein binding 18 6.60e-01 -5.99e-02 0.886000
GO:0036297 interstrand cross-link repair 24 6.11e-01 -5.99e-02 0.867000
GO:0031418 L-ascorbic acid binding 14 6.98e-01 -5.99e-02 0.899000
GO:0043001 Golgi to plasma membrane protein transport 21 6.35e-01 -5.98e-02 0.877000
GO:0008285 negative regulation of cell population proliferation 117 2.67e-01 -5.95e-02 0.708000
GO:0048147 negative regulation of fibroblast proliferation 15 6.93e-01 -5.89e-02 0.898000
GO:0021987 cerebral cortex development 25 6.11e-01 5.88e-02 0.867000
GO:0006325 chromatin organization 66 4.10e-01 -5.87e-02 0.784000
GO:0004497 monooxygenase activity 12 7.27e-01 5.82e-02 0.910000
GO:0016607 nuclear speck 243 1.20e-01 -5.80e-02 0.513000
GO:0009986 cell surface 181 1.80e-01 -5.79e-02 0.610000
GO:0008542 visual learning 20 6.54e-01 -5.79e-02 0.886000
GO:0006891 intra-Golgi vesicle-mediated transport 19 6.62e-01 -5.79e-02 0.886000
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 11 7.41e-01 -5.76e-02 0.914000
GO:0035091 phosphatidylinositol binding 75 3.89e-01 5.75e-02 0.784000
GO:0008408 3’-5’ exonuclease activity 10 7.53e-01 5.75e-02 0.917000
GO:0048015 phosphatidylinositol-mediated signaling 18 6.74e-01 5.72e-02 0.891000
GO:0043565 sequence-specific DNA binding 57 4.55e-01 5.72e-02 0.794000
GO:0043687 post-translational protein modification 19 6.66e-01 -5.71e-02 0.887000
GO:0071949 FAD binding 27 6.08e-01 -5.71e-02 0.867000
GO:0090734 site of DNA damage 22 6.43e-01 -5.70e-02 0.878000
GO:0016592 mediator complex 28 6.02e-01 5.70e-02 0.866000
GO:0003712 transcription coregulator activity 76 3.93e-01 5.67e-02 0.784000
GO:0007018 microtubule-based movement 41 5.30e-01 -5.67e-02 0.832000
GO:0030866 cortical actin cytoskeleton organization 20 6.61e-01 -5.66e-02 0.886000
GO:0036211 protein modification process 16 6.96e-01 -5.65e-02 0.898000
GO:0010634 positive regulation of epithelial cell migration 19 6.70e-01 -5.65e-02 0.891000
GO:0019900 kinase binding 49 4.95e-01 -5.64e-02 0.812000
GO:0000151 ubiquitin ligase complex 48 5.00e-01 -5.63e-02 0.818000
GO:0050821 protein stabilization 109 3.11e-01 -5.63e-02 0.740000
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 24 6.34e-01 -5.62e-02 0.877000
GO:0050772 positive regulation of axonogenesis 12 7.38e-01 -5.58e-02 0.913000
GO:0048666 neuron development 26 6.25e-01 -5.54e-02 0.873000
GO:0070373 negative regulation of ERK1 and ERK2 cascade 30 6.00e-01 -5.54e-02 0.866000
GO:0003779 actin binding 144 2.54e-01 -5.52e-02 0.700000
GO:0060090 molecular adaptor activity 75 4.09e-01 5.52e-02 0.784000
GO:0005815 microtubule organizing center 37 5.62e-01 -5.51e-02 0.850000
GO:0005783 endoplasmic reticulum 437 4.95e-02 -5.51e-02 0.356000
GO:0042733 embryonic digit morphogenesis 29 6.10e-01 -5.48e-02 0.867000
GO:0005739 mitochondrion 609 2.19e-02 -5.48e-02 0.241000
GO:0007409 axonogenesis 40 5.50e-01 5.47e-02 0.847000
GO:0016055 Wnt signaling pathway 79 4.02e-01 5.46e-02 0.784000
GO:0030424 axon 120 3.04e-01 5.44e-02 0.736000
GO:0007026 negative regulation of microtubule depolymerization 17 6.99e-01 -5.41e-02 0.899000
GO:0050870 positive regulation of T cell activation 14 7.29e-01 5.36e-02 0.910000
GO:0030742 GTP-dependent protein binding 13 7.38e-01 5.36e-02 0.913000
GO:0009898 cytoplasmic side of plasma membrane 49 5.17e-01 -5.35e-02 0.829000
GO:0043025 neuronal cell body 86 3.94e-01 5.33e-02 0.784000
GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction 14 7.31e-01 -5.31e-02 0.910000
GO:0004435 phosphatidylinositol phospholipase C activity 12 7.51e-01 -5.30e-02 0.917000
GO:0008360 regulation of cell shape 60 4.78e-01 -5.30e-02 0.806000
GO:0050905 neuromuscular process 10 7.72e-01 -5.29e-02 0.922000
GO:0071260 cellular response to mechanical stimulus 23 6.61e-01 5.29e-02 0.886000
GO:0009411 response to UV 23 6.61e-01 -5.29e-02 0.886000
GO:0008017 microtubule binding 153 2.60e-01 -5.28e-02 0.702000
GO:0098609 cell-cell adhesion 84 4.03e-01 5.28e-02 0.784000
GO:0031175 neuron projection development 50 5.19e-01 5.28e-02 0.829000
GO:2001235 positive regulation of apoptotic signaling pathway 16 7.15e-01 -5.27e-02 0.904000
GO:0051879 Hsp90 protein binding 26 6.42e-01 -5.26e-02 0.877000
GO:0099560 synaptic membrane adhesion 15 7.24e-01 -5.26e-02 0.910000
GO:0007095 mitotic G2 DNA damage checkpoint signaling 30 6.20e-01 -5.23e-02 0.872000
GO:0045111 intermediate filament cytoskeleton 23 6.65e-01 5.23e-02 0.887000
GO:0030670 phagocytic vesicle membrane 19 6.94e-01 5.22e-02 0.898000
GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site 16 7.18e-01 -5.22e-02 0.906000
GO:0050796 regulation of insulin secretion 12 7.55e-01 5.20e-02 0.917000
GO:0003677 DNA binding 337 1.04e-01 -5.18e-02 0.479000
GO:0048821 erythrocyte development 15 7.28e-01 -5.18e-02 0.910000
GO:0006366 transcription by RNA polymerase II 73 4.45e-01 -5.18e-02 0.794000
GO:0051403 stress-activated MAPK cascade 12 7.56e-01 -5.17e-02 0.917000
GO:0098685 Schaffer collateral - CA1 synapse 42 5.64e-01 5.15e-02 0.850000
GO:0007405 neuroblast proliferation 21 6.85e-01 5.12e-02 0.895000
GO:1900182 positive regulation of protein localization to nucleus 25 6.58e-01 5.12e-02 0.886000
GO:0008137 NADH dehydrogenase (ubiquinone) activity 10 7.79e-01 -5.12e-02 0.922000
GO:0005813 centrosome 344 1.05e-01 -5.11e-02 0.483000
GO:0000786 nucleosome 16 7.24e-01 5.10e-02 0.910000
GO:0006338 chromatin remodeling 250 1.68e-01 5.08e-02 0.594000
GO:0032039 integrator complex 15 7.36e-01 -5.04e-02 0.913000
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 14 7.44e-01 5.03e-02 0.915000
GO:0045165 cell fate commitment 20 6.97e-01 5.03e-02 0.899000
GO:0031201 SNARE complex 33 6.17e-01 5.03e-02 0.870000
GO:0031681 G-protein beta-subunit binding 10 7.84e-01 5.00e-02 0.924000
GO:0051497 negative regulation of stress fiber assembly 18 7.15e-01 4.98e-02 0.904000
GO:0140326 ATPase-coupled intramembrane lipid transporter activity 11 7.75e-01 -4.97e-02 0.922000
GO:0060391 positive regulation of SMAD protein signal transduction 13 7.57e-01 4.96e-02 0.917000
GO:0030032 lamellipodium assembly 21 6.94e-01 4.96e-02 0.898000
GO:0043240 Fanconi anaemia nuclear complex 11 7.76e-01 -4.95e-02 0.922000
GO:0045787 positive regulation of cell cycle 13 7.57e-01 -4.95e-02 0.917000
GO:0000423 mitophagy 31 6.34e-01 -4.95e-02 0.877000
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 75 4.62e-01 -4.91e-02 0.797000
GO:0006511 ubiquitin-dependent protein catabolic process 117 3.60e-01 -4.91e-02 0.770000
GO:0034237 protein kinase A regulatory subunit binding 15 7.46e-01 -4.84e-02 0.915000
GO:1905168 positive regulation of double-strand break repair via homologous recombination 25 6.75e-01 -4.84e-02 0.891000
GO:0008344 adult locomotory behavior 24 6.82e-01 -4.83e-02 0.895000
GO:0050729 positive regulation of inflammatory response 21 7.02e-01 -4.83e-02 0.900000
GO:0097352 autophagosome maturation 23 6.90e-01 -4.81e-02 0.895000
GO:0005743 mitochondrial inner membrane 182 2.64e-01 -4.81e-02 0.708000
GO:0002088 lens development in camera-type eye 12 7.74e-01 4.78e-02 0.922000
GO:0005737 cytoplasm 2189 3.57e-04 -4.78e-02 0.022800
GO:0045116 protein neddylation 10 7.94e-01 -4.76e-02 0.929000
GO:0005178 integrin binding 66 5.05e-01 4.74e-02 0.824000
GO:0006744 ubiquinone biosynthetic process 11 7.86e-01 -4.74e-02 0.925000
GO:0045944 positive regulation of transcription by RNA polymerase II 524 6.55e-02 4.73e-02 0.395000
GO:0048146 positive regulation of fibroblast proliferation 18 7.28e-01 -4.73e-02 0.910000
GO:0060045 positive regulation of cardiac muscle cell proliferation 12 7.77e-01 4.72e-02 0.922000
GO:0006882 intracellular zinc ion homeostasis 13 7.69e-01 4.70e-02 0.922000
GO:0006506 GPI anchor biosynthetic process 25 6.86e-01 4.68e-02 0.895000
GO:0090314 positive regulation of protein targeting to membrane 12 7.79e-01 -4.68e-02 0.922000
GO:0001817 regulation of cytokine production 25 6.86e-01 4.67e-02 0.895000
GO:0070536 protein K63-linked deubiquitination 16 7.47e-01 4.67e-02 0.916000
GO:0033209 tumor necrosis factor-mediated signaling pathway 15 7.55e-01 -4.66e-02 0.917000
GO:0043021 ribonucleoprotein complex binding 23 7.00e-01 -4.65e-02 0.899000
GO:0030992 intraciliary transport particle B 15 7.56e-01 -4.64e-02 0.917000
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 14 7.64e-01 -4.64e-02 0.921000
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 14 7.64e-01 4.63e-02 0.921000
GO:0042393 histone binding 95 4.37e-01 -4.62e-02 0.794000
GO:0031290 retinal ganglion cell axon guidance 13 7.75e-01 4.58e-02 0.922000
GO:0048812 neuron projection morphogenesis 30 6.66e-01 4.55e-02 0.887000
GO:0061077 chaperone-mediated protein folding 16 7.53e-01 -4.55e-02 0.917000
GO:0031901 early endosome membrane 76 4.94e-01 -4.54e-02 0.812000
GO:0008283 cell population proliferation 66 5.24e-01 4.54e-02 0.832000
GO:0098982 GABA-ergic synapse 29 6.73e-01 4.53e-02 0.891000
GO:0060586 multicellular organismal-level iron ion homeostasis 15 7.61e-01 -4.53e-02 0.920000
GO:0097110 scaffold protein binding 28 6.79e-01 -4.53e-02 0.893000
GO:0006954 inflammatory response 82 4.79e-01 4.52e-02 0.806000
GO:0030521 androgen receptor signaling pathway 12 7.87e-01 -4.50e-02 0.926000
GO:0030971 receptor tyrosine kinase binding 32 6.60e-01 -4.50e-02 0.886000
GO:0019838 growth factor binding 11 7.97e-01 4.48e-02 0.929000
GO:0010468 regulation of gene expression 58 5.57e-01 4.46e-02 0.850000
GO:0010314 phosphatidylinositol-5-phosphate binding 11 7.98e-01 4.46e-02 0.929000
GO:0009968 negative regulation of signal transduction 14 7.73e-01 -4.45e-02 0.922000
GO:0043065 positive regulation of apoptotic process 123 3.96e-01 -4.44e-02 0.784000
GO:0003714 transcription corepressor activity 100 4.44e-01 -4.44e-02 0.794000
GO:0032956 regulation of actin cytoskeleton organization 37 6.41e-01 -4.43e-02 0.877000
GO:0006355 regulation of DNA-templated transcription 160 3.37e-01 4.41e-02 0.758000
GO:0140861 DNA repair-dependent chromatin remodeling 14 7.75e-01 4.41e-02 0.922000
GO:0042383 sarcolemma 36 6.48e-01 -4.41e-02 0.881000
GO:0031032 actomyosin structure organization 18 7.49e-01 4.36e-02 0.916000
GO:0005881 cytoplasmic microtubule 30 6.80e-01 4.35e-02 0.894000
GO:0006486 protein glycosylation 46 6.10e-01 4.35e-02 0.867000
GO:0010008 endosome membrane 86 4.88e-01 -4.33e-02 0.811000
GO:0030178 negative regulation of Wnt signaling pathway 17 7.58e-01 4.32e-02 0.917000
GO:1990756 ubiquitin-like ligase-substrate adaptor activity 72 5.27e-01 -4.31e-02 0.832000
GO:0042149 cellular response to glucose starvation 29 6.88e-01 4.31e-02 0.895000
GO:0016328 lateral plasma membrane 24 7.15e-01 -4.30e-02 0.904000
GO:0045879 negative regulation of smoothened signaling pathway 16 7.66e-01 4.30e-02 0.922000
GO:0050918 positive chemotaxis 13 7.90e-01 -4.26e-02 0.929000
GO:0034220 monoatomic ion transmembrane transport 20 7.42e-01 4.25e-02 0.914000
GO:0048010 vascular endothelial growth factor receptor signaling pathway 13 7.91e-01 4.25e-02 0.929000
GO:0005524 ATP binding 900 3.34e-02 -4.23e-02 0.308000
GO:0005634 nucleus 2132 1.95e-03 -4.19e-02 0.053800
GO:0005509 calcium ion binding 263 2.45e-01 4.18e-02 0.697000
GO:0140672 ATAC complex 11 8.11e-01 -4.17e-02 0.935000
GO:0045271 respiratory chain complex I 31 6.88e-01 -4.17e-02 0.895000
GO:0071277 cellular response to calcium ion 31 6.89e-01 -4.16e-02 0.895000
GO:0007266 Rho protein signal transduction 33 6.80e-01 4.14e-02 0.894000
GO:0071007 U2-type catalytic step 2 spliceosome 24 7.26e-01 -4.14e-02 0.910000
GO:0051019 mitogen-activated protein kinase binding 11 8.12e-01 4.14e-02 0.936000
GO:0009408 response to heat 19 7.55e-01 -4.13e-02 0.917000
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 32 6.86e-01 -4.13e-02 0.895000
GO:0070628 proteasome binding 13 7.97e-01 4.12e-02 0.929000
GO:0030140 trans-Golgi network transport vesicle 11 8.14e-01 4.10e-02 0.936000
GO:0098794 postsynapse 65 5.73e-01 -4.05e-02 0.853000
GO:0050839 cell adhesion molecule binding 20 7.56e-01 4.02e-02 0.917000
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 43 6.49e-01 -4.01e-02 0.882000
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 28 7.15e-01 -3.99e-02 0.904000
GO:0007005 mitochondrion organization 61 5.91e-01 -3.98e-02 0.865000
GO:0060079 excitatory postsynaptic potential 16 7.83e-01 3.97e-02 0.924000
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 23 7.42e-01 3.97e-02 0.914000
GO:0043410 positive regulation of MAPK cascade 61 5.93e-01 3.96e-02 0.866000
GO:0050885 neuromuscular process controlling balance 25 7.32e-01 3.95e-02 0.911000
GO:0003676 nucleic acid binding 106 4.83e-01 -3.95e-02 0.806000
GO:0033962 P-body assembly 14 8.00e-01 3.92e-02 0.930000
GO:0016235 aggresome 17 7.80e-01 -3.91e-02 0.922000
GO:0035770 ribonucleoprotein granule 13 8.08e-01 -3.90e-02 0.934000
GO:0051607 defense response to virus 56 6.15e-01 -3.89e-02 0.868000
GO:0007214 gamma-aminobutyric acid signaling pathway 11 8.23e-01 3.89e-02 0.941000
GO:0016477 cell migration 138 4.32e-01 -3.88e-02 0.793000
GO:0098978 glutamatergic synapse 233 3.10e-01 3.87e-02 0.740000
GO:0032259 methylation 76 5.60e-01 3.87e-02 0.850000
GO:0009636 response to toxic substance 15 7.97e-01 -3.84e-02 0.929000
GO:0032266 phosphatidylinositol-3-phosphate binding 32 7.07e-01 3.84e-02 0.901000
GO:0071806 protein transmembrane transport 12 8.18e-01 -3.84e-02 0.939000
GO:1902600 proton transmembrane transport 59 6.11e-01 3.83e-02 0.867000
GO:0043066 negative regulation of apoptotic process 150 4.21e-01 -3.81e-02 0.787000
GO:0030659 cytoplasmic vesicle membrane 43 6.66e-01 3.81e-02 0.887000
GO:0140374 antiviral innate immune response 20 7.70e-01 3.79e-02 0.922000
GO:0098552 side of membrane 16 7.93e-01 3.78e-02 0.929000
GO:0000502 proteasome complex 13 8.13e-01 -3.78e-02 0.936000
GO:0043524 negative regulation of neuron apoptotic process 51 6.41e-01 3.78e-02 0.877000
GO:0048477 oogenesis 14 8.07e-01 3.78e-02 0.934000
GO:0008023 transcription elongation factor complex 14 8.07e-01 3.77e-02 0.934000
GO:0044389 ubiquitin-like protein ligase binding 16 7.95e-01 -3.75e-02 0.929000
GO:0043204 perikaryon 35 7.02e-01 -3.74e-02 0.900000
GO:0090575 RNA polymerase II transcription regulator complex 53 6.41e-01 3.71e-02 0.877000
GO:0043005 neuron projection 98 5.28e-01 -3.69e-02 0.832000
GO:0016525 negative regulation of angiogenesis 35 7.07e-01 3.68e-02 0.901000
GO:0016239 positive regulation of macroautophagy 17 7.94e-01 -3.67e-02 0.929000
GO:0008237 metallopeptidase activity 12 8.27e-01 3.64e-02 0.943000
GO:0009306 protein secretion 20 7.78e-01 -3.64e-02 0.922000
GO:0030134 COPII-coated ER to Golgi transport vesicle 22 7.68e-01 -3.63e-02 0.922000
GO:0005096 GTPase activator activity 153 4.40e-01 3.62e-02 0.794000
GO:0050769 positive regulation of neurogenesis 12 8.28e-01 -3.62e-02 0.943000
GO:0031623 receptor internalization 21 7.74e-01 3.62e-02 0.922000
GO:0030246 carbohydrate binding 41 6.89e-01 3.61e-02 0.895000
GO:0051289 protein homotetramerization 36 7.08e-01 -3.61e-02 0.902000
GO:0051604 protein maturation 20 7.81e-01 -3.60e-02 0.922000
GO:0006094 gluconeogenesis 20 7.81e-01 -3.59e-02 0.923000
GO:0032496 response to lipopolysaccharide 37 7.07e-01 3.58e-02 0.901000
GO:0098655 monoatomic cation transmembrane transport 15 8.11e-01 3.57e-02 0.935000
GO:0051015 actin filament binding 123 4.95e-01 -3.56e-02 0.812000
GO:0035198 miRNA binding 21 7.78e-01 3.56e-02 0.922000
GO:0030507 spectrin binding 13 8.25e-01 3.55e-02 0.942000
GO:0060173 limb development 23 7.69e-01 3.54e-02 0.922000
GO:0051726 regulation of cell cycle 104 5.34e-01 -3.54e-02 0.832000
GO:0032587 ruffle membrane 41 6.96e-01 3.53e-02 0.898000
GO:0000175 3’-5’-RNA exonuclease activity 21 7.80e-01 -3.52e-02 0.922000
GO:0030897 HOPS complex 10 8.49e-01 -3.48e-02 0.954000
GO:0071805 potassium ion transmembrane transport 40 7.04e-01 -3.48e-02 0.900000
GO:0035556 intracellular signal transduction 187 4.15e-01 3.47e-02 0.786000
GO:0060337 type I interferon-mediated signaling pathway 10 8.50e-01 3.46e-02 0.954000
GO:0048488 synaptic vesicle endocytosis 21 7.84e-01 -3.45e-02 0.924000
GO:0004930 G protein-coupled receptor activity 61 6.41e-01 -3.45e-02 0.877000
GO:0042098 T cell proliferation 16 8.11e-01 -3.45e-02 0.935000
GO:0034451 centriolar satellite 73 6.11e-01 -3.45e-02 0.867000
GO:0070300 phosphatidic acid binding 13 8.30e-01 3.44e-02 0.945000
GO:0030218 erythrocyte differentiation 27 7.58e-01 -3.43e-02 0.917000
GO:0050804 modulation of chemical synaptic transmission 35 7.26e-01 3.43e-02 0.910000
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 40 7.10e-01 3.40e-02 0.903000
GO:1990138 neuron projection extension 10 8.54e-01 -3.35e-02 0.955000
GO:0000266 mitochondrial fission 10 8.55e-01 -3.34e-02 0.955000
GO:0005886 plasma membrane 1536 3.31e-02 3.32e-02 0.306000
GO:0070588 calcium ion transmembrane transport 44 7.04e-01 -3.31e-02 0.900000
GO:0043015 gamma-tubulin binding 21 7.93e-01 3.31e-02 0.929000
GO:0001819 positive regulation of cytokine production 13 8.38e-01 3.28e-02 0.951000
GO:0046330 positive regulation of JNK cascade 37 7.31e-01 3.27e-02 0.910000
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 10 8.58e-01 -3.26e-02 0.956000
GO:0004622 lysophospholipase activity 10 8.59e-01 3.25e-02 0.956000
GO:0097060 synaptic membrane 11 8.52e-01 3.25e-02 0.955000
GO:0006487 protein N-linked glycosylation 30 7.59e-01 -3.24e-02 0.917000
GO:0030154 cell differentiation 140 5.10e-01 -3.23e-02 0.829000
GO:1905564 positive regulation of vascular endothelial cell proliferation 10 8.60e-01 -3.22e-02 0.956000
GO:0046835 carbohydrate phosphorylation 20 8.04e-01 3.20e-02 0.933000
GO:0043495 protein-membrane adaptor activity 17 8.19e-01 -3.20e-02 0.939000
GO:0005802 trans-Golgi network 100 5.82e-01 -3.19e-02 0.861000
GO:0071577 zinc ion transmembrane transport 10 8.62e-01 3.18e-02 0.956000
GO:0043409 negative regulation of MAPK cascade 21 8.01e-01 -3.18e-02 0.931000
GO:0042626 ATPase-coupled transmembrane transporter activity 17 8.21e-01 3.17e-02 0.939000
GO:0006887 exocytosis 44 7.17e-01 -3.16e-02 0.906000
GO:0042073 intraciliary transport 16 8.27e-01 -3.16e-02 0.943000
GO:0042789 mRNA transcription by RNA polymerase II 25 7.87e-01 3.13e-02 0.926000
GO:0009952 anterior/posterior pattern specification 42 7.26e-01 3.12e-02 0.910000
GO:0097038 perinuclear endoplasmic reticulum 10 8.64e-01 -3.12e-02 0.957000
GO:0009410 response to xenobiotic stimulus 48 7.10e-01 3.10e-02 0.903000
GO:0005911 cell-cell junction 78 6.36e-01 3.10e-02 0.877000
GO:0019894 kinesin binding 21 8.08e-01 3.06e-02 0.934000
GO:0001578 microtubule bundle formation 15 8.37e-01 3.06e-02 0.951000
GO:0002250 adaptive immune response 20 8.13e-01 -3.05e-02 0.936000
GO:0046982 protein heterodimerization activity 130 5.52e-01 -3.03e-02 0.847000
GO:0030159 signaling receptor complex adaptor activity 13 8.50e-01 3.02e-02 0.954000
GO:0007166 cell surface receptor signaling pathway 39 7.44e-01 3.02e-02 0.915000
GO:0005925 focal adhesion 114 5.78e-01 -3.02e-02 0.858000
GO:0044782 cilium organization 13 8.51e-01 3.01e-02 0.954000
GO:0045211 postsynaptic membrane 54 7.04e-01 -2.99e-02 0.900000
GO:0060261 positive regulation of transcription initiation by RNA polymerase II 30 7.77e-01 2.99e-02 0.922000
GO:0019904 protein domain specific binding 104 5.99e-01 2.99e-02 0.866000
GO:0032728 positive regulation of interferon-beta production 15 8.41e-01 2.99e-02 0.952000
GO:0007264 small GTPase-mediated signal transduction 46 7.26e-01 2.98e-02 0.910000
GO:0070979 protein K11-linked ubiquitination 22 8.09e-01 -2.97e-02 0.935000
GO:0042169 SH2 domain binding 20 8.19e-01 -2.96e-02 0.939000
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 14 8.48e-01 2.95e-02 0.954000
GO:0045121 membrane raft 76 6.57e-01 2.95e-02 0.886000
GO:0030878 thyroid gland development 14 8.50e-01 2.92e-02 0.954000
GO:0000794 condensed nuclear chromosome 20 8.22e-01 -2.90e-02 0.941000
GO:0004177 aminopeptidase activity 13 8.57e-01 2.89e-02 0.955000
GO:0012505 endomembrane system 97 6.23e-01 -2.89e-02 0.873000
GO:0007389 pattern specification process 13 8.57e-01 2.89e-02 0.955000
GO:0016604 nuclear body 172 5.15e-01 -2.88e-02 0.829000
GO:0045766 positive regulation of angiogenesis 52 7.19e-01 -2.88e-02 0.907000
GO:0030426 growth cone 41 7.50e-01 -2.87e-02 0.917000
GO:0007411 axon guidance 81 6.58e-01 2.85e-02 0.886000
GO:0031333 negative regulation of protein-containing complex assembly 16 8.44e-01 2.84e-02 0.953000
GO:0035264 multicellular organism growth 67 6.88e-01 2.83e-02 0.895000
GO:0005930 axoneme 48 7.34e-01 2.83e-02 0.913000
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 36 7.69e-01 -2.83e-02 0.922000
GO:0004714 transmembrane receptor protein tyrosine kinase activity 15 8.51e-01 2.80e-02 0.954000
GO:0045087 innate immune response 82 6.62e-01 -2.79e-02 0.886000
GO:0005125 cytokine activity 28 7.98e-01 -2.79e-02 0.929000
GO:0006955 immune response 42 7.55e-01 -2.79e-02 0.917000
GO:0015630 microtubule cytoskeleton 72 6.83e-01 2.78e-02 0.895000
GO:0034504 protein localization to nucleus 20 8.31e-01 -2.77e-02 0.945000
GO:0045893 positive regulation of DNA-templated transcription 224 4.77e-01 2.76e-02 0.806000
GO:0055085 transmembrane transport 87 6.57e-01 -2.75e-02 0.886000
GO:0007420 brain development 78 6.75e-01 -2.75e-02 0.891000
GO:0048012 hepatocyte growth factor receptor signaling pathway 18 8.41e-01 2.74e-02 0.952000
GO:0000149 SNARE binding 31 7.93e-01 2.72e-02 0.929000
GO:0030317 flagellated sperm motility 30 7.97e-01 2.71e-02 0.929000
GO:0003713 transcription coactivator activity 127 6.00e-01 2.70e-02 0.866000
GO:0070301 cellular response to hydrogen peroxide 24 8.20e-01 -2.68e-02 0.939000
GO:0006816 calcium ion transport 19 8.41e-01 -2.66e-02 0.952000
GO:0016236 macroautophagy 16 8.54e-01 2.66e-02 0.955000
GO:0034198 cellular response to amino acid starvation 31 7.98e-01 2.65e-02 0.929000
GO:0032981 mitochondrial respiratory chain complex I assembly 38 7.78e-01 2.65e-02 0.922000
GO:0045494 photoreceptor cell maintenance 25 8.21e-01 2.62e-02 0.939000
GO:0019005 SCF ubiquitin ligase complex 43 7.67e-01 -2.61e-02 0.922000
GO:0043231 intracellular membrane-bounded organelle 118 6.25e-01 -2.61e-02 0.873000
GO:0020037 heme binding 52 7.45e-01 -2.61e-02 0.915000
GO:0002020 protease binding 44 7.70e-01 2.55e-02 0.922000
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 19 8.48e-01 2.54e-02 0.954000
GO:0016192 vesicle-mediated transport 101 6.59e-01 -2.54e-02 0.886000
GO:0045022 early endosome to late endosome transport 19 8.48e-01 -2.53e-02 0.954000
GO:0007283 spermatogenesis 101 6.61e-01 -2.53e-02 0.886000
GO:0045666 positive regulation of neuron differentiation 26 8.25e-01 -2.51e-02 0.942000
GO:1990837 sequence-specific double-stranded DNA binding 47 7.67e-01 2.50e-02 0.922000
GO:0034244 negative regulation of transcription elongation by RNA polymerase II 13 8.77e-01 2.49e-02 0.962000
GO:0005516 calmodulin binding 70 7.21e-01 2.47e-02 0.908000
GO:0019901 protein kinase binding 234 5.19e-01 -2.46e-02 0.829000
GO:0070577 lysine-acetylated histone binding 16 8.66e-01 -2.43e-02 0.957000
GO:0030206 chondroitin sulfate biosynthetic process 11 8.90e-01 2.41e-02 0.965000
GO:0000902 cell morphogenesis 56 7.56e-01 2.41e-02 0.917000
GO:0016180 snRNA processing 10 8.95e-01 2.40e-02 0.966000
GO:0007346 regulation of mitotic cell cycle 30 8.21e-01 -2.39e-02 0.939000
GO:0034097 response to cytokine 12 8.86e-01 2.39e-02 0.964000
GO:0000932 P-body 61 7.48e-01 -2.38e-02 0.916000
GO:0038061 non-canonical NF-kappaB signal transduction 11 8.92e-01 2.38e-02 0.965000
GO:0001702 gastrulation with mouth forming second 10 8.97e-01 2.36e-02 0.966000
GO:0000242 pericentriolar material 14 8.78e-01 -2.36e-02 0.962000
GO:0045727 positive regulation of translation 36 8.06e-01 -2.36e-02 0.934000
GO:0000045 autophagosome assembly 52 7.70e-01 -2.35e-02 0.922000
GO:0006622 protein targeting to lysosome 15 8.75e-01 2.34e-02 0.961000
GO:0015459 potassium channel regulator activity 16 8.75e-01 -2.28e-02 0.961000
GO:0072659 protein localization to plasma membrane 74 7.35e-01 -2.28e-02 0.913000
GO:0008284 positive regulation of cell population proliferation 158 6.24e-01 -2.26e-02 0.873000
GO:0007596 blood coagulation 26 8.42e-01 2.26e-02 0.952000
GO:0030220 platelet formation 11 8.97e-01 -2.25e-02 0.966000
GO:0046872 metal ion binding 877 2.66e-01 -2.24e-02 0.708000
GO:0005868 cytoplasmic dynein complex 14 8.85e-01 -2.23e-02 0.964000
GO:0001707 mesoderm formation 15 8.81e-01 -2.23e-02 0.963000
GO:0032757 positive regulation of interleukin-8 production 16 8.78e-01 -2.21e-02 0.962000
GO:0030010 establishment of cell polarity 19 8.68e-01 2.20e-02 0.958000
GO:0098586 cellular response to virus 22 8.59e-01 -2.18e-02 0.956000
GO:0016251 RNA polymerase II general transcription initiation factor activity 22 8.60e-01 -2.17e-02 0.956000
GO:0030168 platelet activation 11 9.02e-01 2.14e-02 0.966000
GO:0000209 protein polyubiquitination 78 7.45e-01 -2.13e-02 0.915000
GO:0007097 nuclear migration 15 8.87e-01 2.11e-02 0.964000
GO:0032991 protein-containing complex 207 6.02e-01 -2.11e-02 0.866000
GO:0007032 endosome organization 28 8.48e-01 -2.10e-02 0.954000
GO:0001221 transcription coregulator binding 17 8.82e-01 2.09e-02 0.963000
GO:0060339 negative regulation of type I interferon-mediated signaling pathway 13 8.97e-01 2.07e-02 0.966000
GO:0030687 preribosome, large subunit precursor 12 9.02e-01 -2.06e-02 0.966000
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 16 8.88e-01 -2.04e-02 0.964000
GO:0045177 apical part of cell 35 8.35e-01 2.04e-02 0.949000
GO:0106222 lncRNA binding 17 8.85e-01 2.02e-02 0.964000
GO:0016460 myosin II complex 12 9.04e-01 2.02e-02 0.966000
GO:0031593 polyubiquitin modification-dependent protein binding 19 8.79e-01 -2.02e-02 0.962000
GO:0031210 phosphatidylcholine binding 18 8.83e-01 2.01e-02 0.963000
GO:0000712 resolution of meiotic recombination intermediates 14 8.97e-01 -2.00e-02 0.966000
GO:0005245 voltage-gated calcium channel activity 11 9.09e-01 2.00e-02 0.970000
GO:0042803 protein homodimerization activity 371 5.10e-01 -2.00e-02 0.829000
GO:0006897 endocytosis 93 7.40e-01 2.00e-02 0.913000
GO:0071456 cellular response to hypoxia 33 8.44e-01 -1.97e-02 0.953000
GO:0008361 regulation of cell size 13 9.02e-01 1.97e-02 0.966000
GO:0050660 flavin adenine dinucleotide binding 32 8.48e-01 -1.96e-02 0.954000
GO:1990904 ribonucleoprotein complex 104 7.30e-01 -1.96e-02 0.910000
GO:0008168 methyltransferase activity 13 9.03e-01 -1.96e-02 0.966000
GO:0044291 cell-cell contact zone 12 9.07e-01 1.96e-02 0.968000
GO:0007613 memory 28 8.61e-01 -1.91e-02 0.956000
GO:0030177 positive regulation of Wnt signaling pathway 18 8.89e-01 -1.90e-02 0.964000
GO:0042472 inner ear morphogenesis 26 8.67e-01 1.90e-02 0.957000
GO:0031966 mitochondrial membrane 39 8.38e-01 1.90e-02 0.951000
GO:0005801 cis-Golgi network 28 8.62e-01 1.89e-02 0.956000
GO:0006879 intracellular iron ion homeostasis 31 8.56e-01 -1.89e-02 0.955000
GO:0048839 inner ear development 12 9.10e-01 1.88e-02 0.970000
GO:0007165 signal transduction 267 5.98e-01 1.88e-02 0.866000
GO:0001570 vasculogenesis 26 8.69e-01 -1.88e-02 0.958000
GO:0006513 protein monoubiquitination 27 8.67e-01 -1.86e-02 0.957000
GO:0006508 proteolysis 176 6.72e-01 1.86e-02 0.891000
GO:0016226 iron-sulfur cluster assembly 17 8.95e-01 -1.84e-02 0.966000
GO:0001938 positive regulation of endothelial cell proliferation 22 8.81e-01 1.84e-02 0.963000
GO:0004842 ubiquitin-protein transferase activity 66 7.96e-01 -1.84e-02 0.929000
GO:0031122 cytoplasmic microtubule organization 28 8.67e-01 -1.83e-02 0.957000
GO:0005856 cytoskeleton 176 6.76e-01 1.83e-02 0.891000
GO:0005768 endosome 113 7.38e-01 1.83e-02 0.913000
GO:0060218 hematopoietic stem cell differentiation 11 9.16e-01 -1.83e-02 0.972000
GO:0051321 meiotic cell cycle 22 8.83e-01 1.82e-02 0.963000
GO:1990782 protein tyrosine kinase binding 15 9.03e-01 -1.81e-02 0.966000
GO:0006805 xenobiotic metabolic process 17 8.98e-01 -1.80e-02 0.966000
GO:0002931 response to ischemia 10 9.22e-01 -1.80e-02 0.973000
GO:0048255 mRNA stabilization 16 9.01e-01 -1.80e-02 0.966000
GO:0007368 determination of left/right symmetry 28 8.71e-01 -1.77e-02 0.959000
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 17 8.99e-01 1.77e-02 0.966000
GO:0000993 RNA polymerase II complex binding 23 8.83e-01 -1.77e-02 0.963000
GO:0016922 nuclear receptor binding 21 8.88e-01 1.77e-02 0.964000
GO:0000122 negative regulation of transcription by RNA polymerase II 395 5.48e-01 1.77e-02 0.847000
GO:0000281 mitotic cytokinesis 34 8.60e-01 -1.74e-02 0.956000
GO:0048144 fibroblast proliferation 22 8.88e-01 -1.73e-02 0.964000
GO:0016323 basolateral plasma membrane 95 7.72e-01 -1.73e-02 0.922000
GO:0005912 adherens junction 71 8.02e-01 -1.72e-02 0.931000
GO:0031663 lipopolysaccharide-mediated signaling pathway 10 9.25e-01 1.72e-02 0.973000
GO:0065003 protein-containing complex assembly 37 8.57e-01 -1.72e-02 0.955000
GO:0005759 mitochondrial matrix 120 7.48e-01 -1.70e-02 0.916000
GO:0060271 cilium assembly 126 7.42e-01 -1.70e-02 0.914000
GO:0001889 liver development 29 8.75e-01 1.69e-02 0.961000
GO:0030837 negative regulation of actin filament polymerization 14 9.14e-01 1.66e-02 0.972000
GO:0030490 maturation of SSU-rRNA 12 9.22e-01 1.64e-02 0.973000
GO:0030334 regulation of cell migration 35 8.67e-01 1.64e-02 0.957000
GO:0048873 homeostasis of number of cells within a tissue 14 9.18e-01 1.59e-02 0.972000
GO:0017053 transcription repressor complex 34 8.73e-01 1.58e-02 0.961000
GO:0005198 structural molecule activity 39 8.65e-01 -1.57e-02 0.957000
GO:0008289 lipid binding 45 8.56e-01 1.57e-02 0.955000
GO:0007015 actin filament organization 73 8.18e-01 -1.56e-02 0.939000
GO:0030330 DNA damage response, signal transduction by p53 class mediator 12 9.26e-01 1.56e-02 0.973000
GO:0004721 phosphoprotein phosphatase activity 21 9.02e-01 -1.55e-02 0.966000
GO:0097718 disordered domain specific binding 15 9.17e-01 -1.55e-02 0.972000
GO:0016020 membrane 963 4.22e-01 -1.55e-02 0.787000
GO:0001669 acrosomal vesicle 27 8.91e-01 1.52e-02 0.965000
GO:0006915 apoptotic process 135 7.62e-01 -1.51e-02 0.920000
GO:0008139 nuclear localization sequence binding 13 9.26e-01 1.50e-02 0.973000
GO:0046540 U4/U6 x U5 tri-snRNP complex 23 9.02e-01 1.49e-02 0.966000
GO:0009953 dorsal/ventral pattern formation 16 9.19e-01 -1.47e-02 0.972000
GO:0016567 protein ubiquitination 155 7.54e-01 -1.46e-02 0.917000
GO:0008092 cytoskeletal protein binding 16 9.20e-01 -1.44e-02 0.972000
GO:0071339 MLL1 complex 18 9.16e-01 -1.44e-02 0.972000
GO:0070161 anchoring junction 18 9.17e-01 1.43e-02 0.972000
GO:0010719 negative regulation of epithelial to mesenchymal transition 16 9.23e-01 1.39e-02 0.973000
GO:0050890 cognition 18 9.20e-01 -1.37e-02 0.972000
GO:0016579 protein deubiquitination 28 9.02e-01 -1.34e-02 0.966000
GO:0002039 p53 binding 45 8.78e-01 1.33e-02 0.962000
GO:0035615 clathrin adaptor activity 10 9.42e-01 -1.33e-02 0.982000
GO:0140416 transcription regulator inhibitor activity 12 9.38e-01 -1.30e-02 0.981000
GO:0048513 animal organ development 11 9.40e-01 -1.30e-02 0.982000
GO:0030331 nuclear estrogen receptor binding 19 9.23e-01 -1.28e-02 0.973000
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 26 9.11e-01 1.27e-02 0.970000
GO:0001935 endothelial cell proliferation 12 9.40e-01 1.25e-02 0.982000
GO:0061630 ubiquitin protein ligase activity 178 7.74e-01 -1.25e-02 0.922000
GO:0042742 defense response to bacterium 28 9.10e-01 -1.24e-02 0.970000
GO:0005814 centriole 92 8.41e-01 1.21e-02 0.952000
GO:0032968 positive regulation of transcription elongation by RNA polymerase II 15 9.36e-01 -1.21e-02 0.981000
GO:0030100 regulation of endocytosis 12 9.44e-01 -1.18e-02 0.982000
GO:0071889 14-3-3 protein binding 15 9.37e-01 1.18e-02 0.981000
GO:0035025 positive regulation of Rho protein signal transduction 10 9.49e-01 -1.17e-02 0.984000
GO:0048741 skeletal muscle fiber development 16 9.36e-01 1.16e-02 0.981000
GO:0032715 negative regulation of interleukin-6 production 14 9.41e-01 -1.15e-02 0.982000
GO:0043408 regulation of MAPK cascade 21 9.28e-01 -1.13e-02 0.976000
GO:0005770 late endosome 75 8.71e-01 -1.09e-02 0.959000
GO:0045109 intermediate filament organization 10 9.53e-01 -1.07e-02 0.986000
GO:0097550 transcription preinitiation complex 12 9.51e-01 1.03e-02 0.985000
GO:0070847 core mediator complex 19 9.38e-01 1.02e-02 0.982000
GO:0036126 sperm flagellum 33 9.19e-01 1.02e-02 0.972000
GO:0016342 catenin complex 14 9.48e-01 -1.00e-02 0.984000
GO:0005484 SNAP receptor activity 26 9.30e-01 -9.96e-03 0.976000
GO:0007417 central nervous system development 41 9.14e-01 9.80e-03 0.972000
GO:0051491 positive regulation of filopodium assembly 15 9.49e-01 9.54e-03 0.984000
GO:0071539 protein localization to centrosome 20 9.42e-01 -9.46e-03 0.982000
GO:0000785 chromatin 242 8.02e-01 9.39e-03 0.931000
GO:0001843 neural tube closure 47 9.12e-01 9.36e-03 0.970000
GO:0000791 euchromatin 30 9.30e-01 -9.30e-03 0.976000
GO:0051216 cartilage development 21 9.43e-01 8.94e-03 0.982000
GO:0009749 response to glucose 14 9.55e-01 -8.76e-03 0.987000
GO:0007605 sensory perception of sound 57 9.10e-01 8.64e-03 0.970000
GO:0070936 protein K48-linked ubiquitination 68 9.05e-01 -8.36e-03 0.967000
GO:0043138 3’-5’ DNA helicase activity 10 9.64e-01 8.21e-03 0.989000
GO:0005685 U1 snRNP 12 9.61e-01 8.19e-03 0.987000
GO:0016324 apical plasma membrane 121 8.80e-01 7.99e-03 0.962000
GO:0005667 transcription regulator complex 92 8.95e-01 7.98e-03 0.966000
GO:0050681 nuclear androgen receptor binding 16 9.56e-01 -7.96e-03 0.987000
GO:0030216 keratinocyte differentiation 27 9.43e-01 -7.92e-03 0.982000
GO:0006633 fatty acid biosynthetic process 22 9.49e-01 7.85e-03 0.984000
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 82 9.02e-01 7.84e-03 0.966000
GO:0003682 chromatin binding 239 8.43e-01 -7.46e-03 0.953000
GO:0008104 protein localization 68 9.16e-01 -7.40e-03 0.972000
GO:0005777 peroxisome 48 9.30e-01 7.31e-03 0.976000
GO:0030665 clathrin-coated vesicle membrane 11 9.67e-01 -7.28e-03 0.990000
GO:0046627 negative regulation of insulin receptor signaling pathway 16 9.60e-01 7.19e-03 0.987000
GO:0007268 chemical synaptic transmission 32 9.45e-01 7.08e-03 0.982000
GO:0030036 actin cytoskeleton organization 106 9.03e-01 -6.83e-03 0.966000
GO:0032580 Golgi cisterna membrane 27 9.53e-01 -6.61e-03 0.986000
GO:0001223 transcription coactivator binding 21 9.60e-01 -6.30e-03 0.987000
GO:0010212 response to ionizing radiation 24 9.58e-01 6.28e-03 0.987000
GO:2000811 negative regulation of anoikis 10 9.74e-01 -5.86e-03 0.991000
GO:0071353 cellular response to interleukin-4 10 9.76e-01 -5.53e-03 0.991000
GO:0004843 cysteine-type deubiquitinase activity 58 9.42e-01 5.52e-03 0.982000
GO:0030308 negative regulation of cell growth 42 9.52e-01 5.39e-03 0.986000
GO:0032467 positive regulation of cytokinesis 14 9.74e-01 -4.96e-03 0.991000
GO:0031463 Cul3-RING ubiquitin ligase complex 42 9.58e-01 -4.69e-03 0.987000
GO:0042127 regulation of cell population proliferation 45 9.57e-01 -4.65e-03 0.987000
GO:0005876 spindle microtubule 20 9.72e-01 4.61e-03 0.991000
GO:0008143 poly(A) binding 13 9.77e-01 4.58e-03 0.992000
GO:0005811 lipid droplet 44 9.58e-01 -4.55e-03 0.987000
GO:1904262 negative regulation of TORC1 signaling 28 9.67e-01 -4.54e-03 0.990000
GO:0031267 small GTPase binding 167 9.23e-01 4.33e-03 0.973000
GO:0005929 cilium 80 9.48e-01 -4.25e-03 0.984000
GO:0010977 negative regulation of neuron projection development 18 9.75e-01 -4.24e-03 0.991000
GO:0044295 axonal growth cone 10 9.82e-01 4.17e-03 0.995000
GO:0006629 lipid metabolic process 53 9.59e-01 4.11e-03 0.987000
GO:0005762 mitochondrial large ribosomal subunit 38 9.66e-01 3.96e-03 0.990000
GO:0035869 ciliary transition zone 22 9.75e-01 -3.82e-03 0.991000
GO:0030163 protein catabolic process 30 9.71e-01 -3.78e-03 0.991000
GO:0001755 neural crest cell migration 27 9.73e-01 3.76e-03 0.991000
GO:0098869 cellular oxidant detoxification 28 9.73e-01 3.75e-03 0.991000
GO:0007267 cell-cell signaling 13 9.82e-01 3.70e-03 0.995000
GO:0005262 calcium channel activity 21 9.79e-01 3.30e-03 0.993000
GO:0001673 male germ cell nucleus 26 9.77e-01 -3.24e-03 0.992000
GO:0031902 late endosome membrane 67 9.64e-01 3.23e-03 0.989000
GO:0004725 protein tyrosine phosphatase activity 44 9.72e-01 -3.11e-03 0.991000
GO:0120009 intermembrane lipid transfer 16 9.85e-01 -2.75e-03 0.995000
GO:0050853 B cell receptor signaling pathway 19 9.84e-01 2.71e-03 0.995000
GO:0005834 heterotrimeric G-protein complex 20 9.84e-01 2.58e-03 0.995000
GO:0045892 negative regulation of DNA-templated transcription 174 9.56e-01 2.46e-03 0.987000
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 68 9.73e-01 2.39e-03 0.991000
GO:0045668 negative regulation of osteoblast differentiation 27 9.83e-01 2.37e-03 0.995000
GO:0140297 DNA-binding transcription factor binding 72 9.73e-01 -2.29e-03 0.991000
GO:0007030 Golgi organization 64 9.75e-01 -2.29e-03 0.991000
GO:0051457 maintenance of protein location in nucleus 10 9.90e-01 2.20e-03 0.998000
GO:0042307 positive regulation of protein import into nucleus 24 9.86e-01 -2.12e-03 0.995000
GO:0019827 stem cell population maintenance 21 9.87e-01 -2.03e-03 0.996000
GO:0004857 enzyme inhibitor activity 13 9.91e-01 -1.90e-03 0.998000
GO:0006974 DNA damage response 119 9.72e-01 1.86e-03 0.991000
GO:0005794 Golgi apparatus 470 9.55e-01 -1.52e-03 0.987000
GO:0003730 mRNA 3’-UTR binding 51 9.86e-01 1.47e-03 0.995000
GO:0001822 kidney development 51 9.86e-01 1.42e-03 0.995000
GO:0006749 glutathione metabolic process 15 9.93e-01 1.22e-03 0.999000
GO:0001658 branching involved in ureteric bud morphogenesis 18 9.94e-01 1.11e-03 0.999000
GO:0007224 smoothened signaling pathway 50 9.91e-01 -8.73e-04 0.998000
GO:0050714 positive regulation of protein secretion 19 9.95e-01 8.28e-04 0.999000
GO:0007528 neuromuscular junction development 14 9.96e-01 6.86e-04 0.999000
GO:0004181 metallocarboxypeptidase activity 13 9.97e-01 6.71e-04 0.999000
GO:0002376 immune system process 12 9.97e-01 5.72e-04 0.999000
GO:0090398 cellular senescence 19 9.97e-01 -5.60e-04 0.999000
GO:0052689 carboxylic ester hydrolase activity 12 9.98e-01 5.15e-04 0.999000
GO:0031647 regulation of protein stability 57 9.97e-01 -3.22e-04 0.999000
GO:0005154 epidermal growth factor receptor binding 19 9.98e-01 2.64e-04 0.999000
GO:0045202 synapse 165 9.98e-01 -8.95e-05 0.999000
GO:0019933 cAMP-mediated signaling 13 1.00e+00 -7.92e-05 1.000000


Detailed Gene set reports



GO:0140662 ATP-dependent protein folding chaperone
set GO:0140662 ATP-dependent protein folding chaperone
setSize 23
pANOVA 2.72e-07
s.dist -0.619
p.adjustANOVA 0.000242


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 -7304
HSPA13 -7268
TCP1 -7010
HSP90B1 -6913
HSPD1 -6595
HSP90AA1 -6441
HSPA4 -6266
CCT8 -5884
HSPA4L -5642
HSPA9 -5619
HSPA8 -5572
HYOU1 -5490
TRAP1 -5429
HSPH1 -5335
CCT4 -4305
CCT7 -4199
CCT5 -3725
HSPA14 -3054
CCT2 -2633
CLPX -1659

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 -7304
HSPA13 -7268
TCP1 -7010
HSP90B1 -6913
HSPD1 -6595
HSP90AA1 -6441
HSPA4 -6266
CCT8 -5884
HSPA4L -5642
HSPA9 -5619
HSPA8 -5572
HYOU1 -5490
TRAP1 -5429
HSPH1 -5335
CCT4 -4305
CCT7 -4199
CCT5 -3725
HSPA14 -3054
CCT2 -2633
CLPX -1659
TOR1A -1399
CCT3 246
HSPA2 2725


GO:0051315 attachment of mitotic spindle microtubules to kinetochore
set GO:0051315 attachment of mitotic spindle microtubules to kinetochore
setSize 10
pANOVA 0.000847
s.dist -0.609
p.adjustANOVA 0.0328


Top enriched genes
Top 20 genes
GeneID Gene Rank
SKA3 -7081
MAPRE1 -6954
KIF2C -6758
NDC80 -6752
NUF2 -6635
MIS12 -6599
MAD1L1 -4055
CENPC -3682
SEH1L -1557
CHAMP1 5199

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SKA3 -7081
MAPRE1 -6954
KIF2C -6758
NDC80 -6752
NUF2 -6635
MIS12 -6599
MAD1L1 -4055
CENPC -3682
SEH1L -1557
CHAMP1 5199


GO:0090201 negative regulation of release of cytochrome c from mitochondria
set GO:0090201 negative regulation of release of cytochrome c from mitochondria
setSize 11
pANOVA 0.00174
s.dist -0.545
p.adjustANOVA 0.0515


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF -7138
OPA1 -6996
TRIAP1 -6630
PRELID1 -6058
PSMD10 -5094
FXN -3691
PPIF -3455
GHITM -2892
PARL -2466
BAK1 -2113
GPX1 2317

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HGF -7138
OPA1 -6996
TRIAP1 -6630
PRELID1 -6058
PSMD10 -5094
FXN -3691
PPIF -3455
GHITM -2892
PARL -2466
BAK1 -2113
GPX1 2317


GO:0001965 G-protein alpha-subunit binding
set GO:0001965 G-protein alpha-subunit binding
setSize 10
pANOVA 0.00422
s.dist 0.523
p.adjustANOVA 0.085


Top enriched genes
Top 20 genes
GeneID Gene Rank
SASH1 7089
RIC8A 6642
RGS22 6550
RIC8B 5488
CCDC88A 5302
RGS10 4876
GPSM1 4747
RGS14 2662
F2RL1 -1239
RGS2 -4520

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All member genes
GeneID Gene Rank
SASH1 7089
RIC8A 6642
RGS22 6550
RIC8B 5488
CCDC88A 5302
RGS10 4876
GPSM1 4747
RGS14 2662
F2RL1 -1239
RGS2 -4520


GO:0000400 four-way junction DNA binding
set GO:0000400 four-way junction DNA binding
setSize 14
pANOVA 0.001
s.dist -0.508
p.adjustANOVA 0.0357


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51B -7158
HMGB2 -7058
XRCC3 -6858
HMGB1 -6553
RAD51C -6005
BLM -5207
RAD51D -4518
MSH2 -4089
MSH6 -2744
GEN1 -2353
XRCC2 -2001
HMGB3 -1912
FANCM 1637
WRN 2377

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51B -7158
HMGB2 -7058
XRCC3 -6858
HMGB1 -6553
RAD51C -6005
BLM -5207
RAD51D -4518
MSH2 -4089
MSH6 -2744
GEN1 -2353
XRCC2 -2001
HMGB3 -1912
FANCM 1637
WRN 2377


GO:0042026 protein refolding
set GO:0042026 protein refolding
setSize 12
pANOVA 0.00234
s.dist -0.507
p.adjustANOVA 0.0592


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 -7304
HSPA13 -7268
HSPD1 -6595
HSPA9 -5619
DNAJA1 -5608
HSPA8 -5572
DNAJA2 -5070
HSPA14 -3054
DNAJB2 -2591
DNAJA4 -1417
HSPB1 2445
HSPA2 2725

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 -7304
HSPA13 -7268
HSPD1 -6595
HSPA9 -5619
DNAJA1 -5608
HSPA8 -5572
DNAJA2 -5070
HSPA14 -3054
DNAJB2 -2591
DNAJA4 -1417
HSPB1 2445
HSPA2 2725


GO:0032212 positive regulation of telomere maintenance via telomerase
set GO:0032212 positive regulation of telomere maintenance via telomerase
setSize 17
pANOVA 0.000351
s.dist -0.501
p.adjustANOVA 0.0228


Top enriched genes
Top 20 genes
GeneID Gene Rank
TCP1 -7010
HNRNPD -6895
PARN -6518
DKC1 -6343
CCT8 -5884
NEK7 -5390
PKIB -5107
PTGES3 -4585
CCT4 -4305
CCT7 -4199
CCT5 -3725
NAF1 -3148
CCT2 -2633
CTNNB1 -1420
CCT3 246
TNKS 1600
POT1 2512

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCP1 -7010
HNRNPD -6895
PARN -6518
DKC1 -6343
CCT8 -5884
NEK7 -5390
PKIB -5107
PTGES3 -4585
CCT4 -4305
CCT7 -4199
CCT5 -3725
NAF1 -3148
CCT2 -2633
CTNNB1 -1420
CCT3 246
TNKS 1600
POT1 2512


GO:0007339 binding of sperm to zona pellucida
set GO:0007339 binding of sperm to zona pellucida
setSize 11
pANOVA 0.00471
s.dist -0.492
p.adjustANOVA 0.0906


Top enriched genes
Top 20 genes
GeneID Gene Rank
TCP1 -7010
CCT8 -5884
ZP3 -4564
ATP8B3 -4450
VDAC2 -4334
CCT7 -4199
CCT5 -3725
UBAP2L -3011
CCT2 -2633
B4GALT1 -402
CCT3 246

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCP1 -7010
CCT8 -5884
ZP3 -4564
ATP8B3 -4450
VDAC2 -4334
CCT7 -4199
CCT5 -3725
UBAP2L -3011
CCT2 -2633
B4GALT1 -402
CCT3 246


GO:0003678 DNA helicase activity
set GO:0003678 DNA helicase activity
setSize 20
pANOVA 0.000148
s.dist -0.49
p.adjustANOVA 0.021


Top enriched genes
Top 20 genes
GeneID Gene Rank
RUVBL1 -7282
MCM4 -6737
BRIP1 -6641
TWNK -6513
XRCC6 -6500
XRCC5 -6329
DDX11 -6070
MCM9 -5993
DHX36 -5359
MCM6 -5347
DHX30 -4993
SUPV3L1 -4596
G3BP1 -4582
MRE11 -2989
RTEL1 -1057
CHD1L -119
RAD50 949
RECQL5 1320
DNA2 2870
SNRNP200 3652

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUVBL1 -7282
MCM4 -6737
BRIP1 -6641
TWNK -6513
XRCC6 -6500
XRCC5 -6329
DDX11 -6070
MCM9 -5993
DHX36 -5359
MCM6 -5347
DHX30 -4993
SUPV3L1 -4596
G3BP1 -4582
MRE11 -2989
RTEL1 -1057
CHD1L -119
RAD50 949
RECQL5 1320
DNA2 2870
SNRNP200 3652


GO:0001782 B cell homeostasis
set GO:0001782 B cell homeostasis
setSize 12
pANOVA 0.005
s.dist 0.468
p.adjustANOVA 0.094


Top enriched genes
Top 20 genes
GeneID Gene Rank
RC3H1 7155
BBS4 5817
PPP2R3C 5484
NCKAP1L 5480
SOS1 4192
RC3H2 3452
BCL2 3266
CAMLG 2238
CASP3 1602
LYN 804
SOS2 673
IL7R 181

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RC3H1 7155
BBS4 5817
PPP2R3C 5484
NCKAP1L 5480
SOS1 4192
RC3H2 3452
BCL2 3266
CAMLG 2238
CASP3 1602
LYN 804
SOS2 673
IL7R 181


GO:0007017 microtubule-based process
set GO:0007017 microtubule-based process
setSize 11
pANOVA 0.0078
s.dist -0.463
p.adjustANOVA 0.128


Top enriched genes
Top 20 genes
GeneID Gene Rank
DYNLL2 -7247
TUBB6 -7224
DNAL4 -6750
TUBB4B -5161
TUBE1 -4882
DCTN3 -4856
TUBD1 -2120
TUBA1A -1786
KIF25 -1272
TUBA8A -373
DYL1 4016

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DYNLL2 -7247
TUBB6 -7224
DNAL4 -6750
TUBB4B -5161
TUBE1 -4882
DCTN3 -4856
TUBD1 -2120
TUBA1A -1786
KIF25 -1272
TUBA8A -373
DYL1 4016


GO:0071233 cellular response to L-leucine
set GO:0071233 cellular response to L-leucine
setSize 10
pANOVA 0.0117
s.dist 0.461
p.adjustANOVA 0.17


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTOR 7057
UBR2 6014
KLHL22 5089
SESN2 4877
RPTOR 4309
UBR1 3529
STAMBPL1 2795
RRAGD 2681
SESN3 -1076
SESN1 -2197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTOR 7057
UBR2 6014
KLHL22 5089
SESN2 4877
RPTOR 4309
UBR1 3529
STAMBPL1 2795
RRAGD 2681
SESN3 -1076
SESN1 -2197


GO:0006913 nucleocytoplasmic transport
set GO:0006913 nucleocytoplasmic transport
setSize 18
pANOVA 0.000728
s.dist -0.46
p.adjustANOVA 0.0303


Top enriched genes
Top 20 genes
GeneID Gene Rank
AAAS -7188
NUP62 -7055
RSRC1 -6699
NUP205 -6348
NUP93 -5886
RANBP1 -5638
FBXO22 -5430
PDLIM7 -5327
NDC1 -5292
AXIN1 -5143
ANKRD54 -4024
NXT2 -3358
NUP85 -359
NUP35 -153
CAMK1 403
NUP58 405
NUP98 2630
NUP153 3311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AAAS -7188
NUP62 -7055
RSRC1 -6699
NUP205 -6348
NUP93 -5886
RANBP1 -5638
FBXO22 -5430
PDLIM7 -5327
NDC1 -5292
AXIN1 -5143
ANKRD54 -4024
NXT2 -3358
NUP85 -359
NUP35 -153
CAMK1 403
NUP58 405
NUP98 2630
NUP153 3311


GO:0003007 heart morphogenesis
set GO:0003007 heart morphogenesis
setSize 16
pANOVA 0.0016
s.dist 0.456
p.adjustANOVA 0.0482


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTOR 7057
TGFBR3 6887
INSR 6160
PITX2 5808
TGFB2 5272
COL5A1 4964
ZMIZ1 4793
TAB1 3574
CHD7 3101
ALDH1A2 2208
ASXL1 1607
ARID2 1113
GAA 1050
FAT4 721
PTCH1 -850
TBXT -1122

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTOR 7057
TGFBR3 6887
INSR 6160
PITX2 5808
TGFB2 5272
COL5A1 4964
ZMIZ1 4793
TAB1 3574
CHD7 3101
ALDH1A2 2208
ASXL1 1607
ARID2 1113
GAA 1050
FAT4 721
PTCH1 -850
TBXT -1122


GO:0030282 bone mineralization
set GO:0030282 bone mineralization
setSize 24
pANOVA 0.000126
s.dist 0.452
p.adjustANOVA 0.0203


Top enriched genes
Top 20 genes
GeneID Gene Rank
AXIN2 7158
COL6A1 7148
FOSL2 6961
COL1A2 6904
ANKH 6610
LOX 6461
RUNX2 6428
SBNO2 5934
PRICKLE1 5686
HIF1A 5245
PTN 4787
WNT11 4770
IFITM5 4128
PHOSPHO1 3143
TMEM38B 1442
LGR4 1387
ATF4 1254
GPC3 1126
SMPD3 960
ALPL -352

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AXIN2 7158
COL6A1 7148
FOSL2 6961
COL1A2 6904
ANKH 6610
LOX 6461
RUNX2 6428
SBNO2 5934
PRICKLE1 5686
HIF1A 5245
PTN 4787
WNT11 4770
IFITM5 4128
PHOSPHO1 3143
TMEM38B 1442
LGR4 1387
ATF4 1254
GPC3 1126
SMPD3 960
ALPL -352
SBDS -735
ENPP1 -2077
ANXA2 -2167
KLF10 -4348


GO:1990166 protein localization to site of double-strand break
set GO:1990166 protein localization to site of double-strand break
setSize 10
pANOVA 0.0146
s.dist -0.446
p.adjustANOVA 0.191


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPA1 -6710
SIRT6 -5169
RAD17 -4758
XRCC4 -4198
HTATSF1 -3827
TP53BP1 -3661
NBN -1765
TOPBP1 -1632
PARP3 -801
SLF1 -446

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA1 -6710
SIRT6 -5169
RAD17 -4758
XRCC4 -4198
HTATSF1 -3827
TP53BP1 -3661
NBN -1765
TOPBP1 -1632
PARP3 -801
SLF1 -446


GO:0072542 protein phosphatase activator activity
set GO:0072542 protein phosphatase activator activity
setSize 10
pANOVA 0.0154
s.dist -0.442
p.adjustANOVA 0.198


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP2R5D -7029
PPP4R3A -6460
TIPRL -6034
PPP2R5C -5841
GNA12 -5417
PHACTR4 -3955
CALM1 -3449
PPP2R5A -2124
PPP2R5E 1967
B3GAT3 5628

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -7029
PPP4R3A -6460
TIPRL -6034
PPP2R5C -5841
GNA12 -5417
PHACTR4 -3955
CALM1 -3449
PPP2R5A -2124
PPP2R5E 1967
B3GAT3 5628


GO:0017116 single-stranded DNA helicase activity
set GO:0017116 single-stranded DNA helicase activity
setSize 16
pANOVA 0.00262
s.dist -0.435
p.adjustANOVA 0.0615


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCM8 -7226
DSCC1 -7100
MCM4 -6737
MCM9 -5993
PIF1 -5585
MCM2 -5199
MCM3 -4846
CHTF8 -4706
RFC3 -3480
POLQ -3424
MCM5 -2094
RFC4 -1460
HELB -804
RFC5 320
DNA2 2870
WRNIP1 4059

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 -7226
DSCC1 -7100
MCM4 -6737
MCM9 -5993
PIF1 -5585
MCM2 -5199
MCM3 -4846
CHTF8 -4706
RFC3 -3480
POLQ -3424
MCM5 -2094
RFC4 -1460
HELB -804
RFC5 320
DNA2 2870
WRNIP1 4059


GO:0000793 condensed chromosome
set GO:0000793 condensed chromosome
setSize 13
pANOVA 0.00691
s.dist -0.433
p.adjustANOVA 0.118


Top enriched genes
Top 20 genes
GeneID Gene Rank
SMARCA5 -7074
HMGB2 -7058
SMC2 -6761
CDK2 -6639
TOP3B -6225
BAZ1B -3975
LIG4 -3612
TOP2A -3505
RIF1 -2035
FANCD2 -1023
NCAPD2 -669
CTCF 3132
NCAPG 3847

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMARCA5 -7074
HMGB2 -7058
SMC2 -6761
CDK2 -6639
TOP3B -6225
BAZ1B -3975
LIG4 -3612
TOP2A -3505
RIF1 -2035
FANCD2 -1023
NCAPD2 -669
CTCF 3132
NCAPG 3847


GO:0030863 cortical cytoskeleton
set GO:0030863 cortical cytoskeleton
setSize 11
pANOVA 0.013
s.dist -0.433
p.adjustANOVA 0.181


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTTN -7171
MPP1 -7096
CAPZA1 -6890
TPM4 -6582
DMTN -5904
CAPZA2 -3750
NOS2 -3428
TMOD1 -90
EPB41 1400
CAPZB 1517
GYPC 2799

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTTN -7171
MPP1 -7096
CAPZA1 -6890
TPM4 -6582
DMTN -5904
CAPZA2 -3750
NOS2 -3428
TMOD1 -90
EPB41 1400
CAPZB 1517
GYPC 2799


GO:0008320 protein transmembrane transporter activity
set GO:0008320 protein transmembrane transporter activity
setSize 11
pANOVA 0.0134
s.dist -0.431
p.adjustANOVA 0.184


Top enriched genes
Top 20 genes
GeneID Gene Rank
SEC63 -7320
TOMM20 -6656
PEX13 -6402
TOMM70 -5930
PEX14 -3865
TIMM17B -3124
SEC61A1 -2813
TIMM22 -2133
SEC61A2 -418
SEC61G 897
TMED10 2722

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEC63 -7320
TOMM20 -6656
PEX13 -6402
TOMM70 -5930
PEX14 -3865
TIMM17B -3124
SEC61A1 -2813
TIMM22 -2133
SEC61A2 -418
SEC61G 897
TMED10 2722


GO:0071333 cellular response to glucose stimulus
set GO:0071333 cellular response to glucose stimulus
setSize 13
pANOVA 0.0072
s.dist 0.43
p.adjustANOVA 0.122


Top enriched genes
Top 20 genes
GeneID Gene Rank
ZBTB20 7221
IGF1R 6973
RACK1 6300
PRKAA1 6228
OGT 5329
PCK2 4381
RPTOR 4309
SLC12A7 2595
PIK3CA 2358
TRA2B 736
ERN1 -563
SIN3A -665
NOX4 -5052

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZBTB20 7221
IGF1R 6973
RACK1 6300
PRKAA1 6228
OGT 5329
PCK2 4381
RPTOR 4309
SLC12A7 2595
PIK3CA 2358
TRA2B 736
ERN1 -563
SIN3A -665
NOX4 -5052


GO:0140658 ATP-dependent chromatin remodeler activity
set GO:0140658 ATP-dependent chromatin remodeler activity
setSize 11
pANOVA 0.0141
s.dist 0.427
p.adjustANOVA 0.189


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHD2 7034
CHD6 5750
CHD4 5621
ERCC6 4206
CHD5 4193
CHD7 3101
CHD1 1995
SMARCAD1 1611
INO80 1135
CHD1L -119
RAD54L2 -806

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHD2 7034
CHD6 5750
CHD4 5621
ERCC6 4206
CHD5 4193
CHD7 3101
CHD1 1995
SMARCAD1 1611
INO80 1135
CHD1L -119
RAD54L2 -806


GO:0007076 mitotic chromosome condensation
set GO:0007076 mitotic chromosome condensation
setSize 10
pANOVA 0.0199
s.dist -0.425
p.adjustANOVA 0.225


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCAPH2 -7217
SMC2 -6761
NUSAP1 -6481
PHF13 -5155
SMC4 -5139
AKAP8L -2345
NCAPH -963
NCAPD2 -669
NCAPD3 -580
NCAPG 3847

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCAPH2 -7217
SMC2 -6761
NUSAP1 -6481
PHF13 -5155
SMC4 -5139
AKAP8L -2345
NCAPH -963
NCAPD2 -669
NCAPD3 -580
NCAPG 3847


GO:0080008 Cul4-RING E3 ubiquitin ligase complex
set GO:0080008 Cul4-RING E3 ubiquitin ligase complex
setSize 13
pANOVA 0.00835
s.dist -0.423
p.adjustANOVA 0.135


Top enriched genes
Top 20 genes
GeneID Gene Rank
DDB2 -7073
DCAF15 -6982
DCAF13 -6882
DDA1 -6593
DDB1 -6484
FBXW5 -5946
WDTC1 -4711
DCAF17 -4221
DCAF10 -4146
DCAF7 337
DCAF6 384
DCAF1 5420
DCAF5 6269

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DDB2 -7073
DCAF15 -6982
DCAF13 -6882
DDA1 -6593
DDB1 -6484
FBXW5 -5946
WDTC1 -4711
DCAF17 -4221
DCAF10 -4146
DCAF7 337
DCAF6 384
DCAF1 5420
DCAF5 6269


GO:0051085 chaperone cofactor-dependent protein refolding
set GO:0051085 chaperone cofactor-dependent protein refolding
setSize 23
pANOVA 0.000463
s.dist -0.422
p.adjustANOVA 0.0228


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 -7304
ST13P5 -7286
HSPA13 -7268
DNAJB5 -7069
SDF2L1 -6569
DNAJC7 -6527
HSPA9 -5619
HSPA8 -5572
HSPH1 -5335
DNAJB1 -4842
PTGES3 -4585
DNAJB14 -4068
DNAJC18 -3160
HSPA14 -3054
HSPE1 -2503
TOR1A -1399
DNAJB4 -355
TOR2A -39
DNAJB12 769
ERO1A 853

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 -7304
ST13P5 -7286
HSPA13 -7268
DNAJB5 -7069
SDF2L1 -6569
DNAJC7 -6527
HSPA9 -5619
HSPA8 -5572
HSPH1 -5335
DNAJB1 -4842
PTGES3 -4585
DNAJB14 -4068
DNAJC18 -3160
HSPA14 -3054
HSPE1 -2503
TOR1A -1399
DNAJB4 -355
TOR2A -39
DNAJB12 769
ERO1A 853
DNAJB13 1408
HSPA2 2725
SDF2 5083


GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
set GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
setSize 11
pANOVA 0.0155
s.dist 0.422
p.adjustANOVA 0.198


Top enriched genes
Top 20 genes
GeneID Gene Rank
TGFBR3 6887
SOX11 6816
LOX 6461
MPP5 6136
TRIM33 3800
LATS2 3518
ZNF703 3076
NREP 2179
ZEB1 519
LATS1 -2619
ITGA3 -3509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGFBR3 6887
SOX11 6816
LOX 6461
MPP5 6136
TRIM33 3800
LATS2 3518
ZNF703 3076
NREP 2179
ZEB1 519
LATS1 -2619
ITGA3 -3509


GO:0001671 ATPase activator activity
set GO:0001671 ATPase activator activity
setSize 18
pANOVA 0.00198
s.dist -0.421
p.adjustANOVA 0.0538


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP1B1 -7121
DNAJA1 -5608
ATP6AP1 -5281
DNAJB6 -5154
DNAJA2 -5070
DNAJC24 -5029
AHSA2 -4890
DNAJB1 -4842
DNAJC10 -4491
TOR1AIP1 -4447
AHSA1 -3558
ATP1B3 -2842
DNAJB2 -2591
DNAJC19 -719
DNAJB4 -355
DNAJC15 38
TOR1AIP2 665
HSCB 5241

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP1B1 -7121
DNAJA1 -5608
ATP6AP1 -5281
DNAJB6 -5154
DNAJA2 -5070
DNAJC24 -5029
AHSA2 -4890
DNAJB1 -4842
DNAJC10 -4491
TOR1AIP1 -4447
AHSA1 -3558
ATP1B3 -2842
DNAJB2 -2591
DNAJC19 -719
DNAJB4 -355
DNAJC15 38
TOR1AIP2 665
HSCB 5241


GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
set GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
setSize 11
pANOVA 0.016
s.dist 0.419
p.adjustANOVA 0.202


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPR146 7082
RIC8A 6642
GABBR2 5374
S1PR1 4035
NPY2R 3381
S1PR3 3317
PSAP 3238
GNAI2 2437
PALM 1332
TAAR1 315
LPAR1 -4064

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPR146 7082
RIC8A 6642
GABBR2 5374
S1PR1 4035
NPY2R 3381
S1PR3 3317
PSAP 3238
GNAI2 2437
PALM 1332
TAAR1 315
LPAR1 -4064


GO:0042407 cristae formation
set GO:0042407 cristae formation
setSize 11
pANOVA 0.0168
s.dist -0.416
p.adjustANOVA 0.206


Top enriched genes
Top 20 genes
GeneID Gene Rank
OPA1 -6996
OMA1 -5991
APOO -5712
IMMT -5454
APOOL -5151
DNAJC11 -4396
CHCHD3 -3163
SAMM50 -1339
LETM1 -947
MINOS1 1771
SLC25A46 3501

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OPA1 -6996
OMA1 -5991
APOO -5712
IMMT -5454
APOOL -5151
DNAJC11 -4396
CHCHD3 -3163
SAMM50 -1339
LETM1 -947
MINOS1 1771
SLC25A46 3501


GO:0007129 homologous chromosome pairing at meiosis
set GO:0007129 homologous chromosome pairing at meiosis
setSize 13
pANOVA 0.00942
s.dist -0.416
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
SGF29 -7065
SUN1 -6399
PSMC3IP -5662
NDC1 -5292
CCNE1 -4962
MLH1 -3603
NAIF1 -3451
MRE11 -2989
DMC1 -1476
FANCD2 -1023
SPATA22 174
MAJIN 669
CCNE2 1073

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SGF29 -7065
SUN1 -6399
PSMC3IP -5662
NDC1 -5292
CCNE1 -4962
MLH1 -3603
NAIF1 -3451
MRE11 -2989
DMC1 -1476
FANCD2 -1023
SPATA22 174
MAJIN 669
CCNE2 1073


GO:0030500 regulation of bone mineralization
set GO:0030500 regulation of bone mineralization
setSize 12
pANOVA 0.0126
s.dist 0.416
p.adjustANOVA 0.179


Top enriched genes
Top 20 genes
GeneID Gene Rank
NOTUM 7214
TXLNG 7031
ANKH 6610
TWIST1 5361
S1PR1 4035
PHOSPHO1 3143
DDR2 2523
BGLAP 1989
BMP2K 1791
SGMS2 -37
NBR1 -1802
ENPP1 -2077

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTUM 7214
TXLNG 7031
ANKH 6610
TWIST1 5361
S1PR1 4035
PHOSPHO1 3143
DDR2 2523
BGLAP 1989
BMP2K 1791
SGMS2 -37
NBR1 -1802
ENPP1 -2077


GO:0005581 collagen trimer
set GO:0005581 collagen trimer
setSize 21
pANOVA 0.000999
s.dist 0.415
p.adjustANOVA 0.0357


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL6A1 7148
COLQ 7123
C1QTNF3 7111
COL3A1 7090
LOX 6461
COL12A1 6069
COL6A2 5944
COL6A3 5927
COL18A1 5868
COLEC12 4937
COL8A2 4925
COL21A1 4027
COL9A2 3559
COLEC11 2149
COL10A1 811
COL17A1 647
COL4A2 527
COL22A1 -2030
COLEC10 -2343
EMID1 -6378

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL6A1 7148
COLQ 7123
C1QTNF3 7111
COL3A1 7090
LOX 6461
COL12A1 6069
COL6A2 5944
COL6A3 5927
COL18A1 5868
COLEC12 4937
COL8A2 4925
COL21A1 4027
COL9A2 3559
COLEC11 2149
COL10A1 811
COL17A1 647
COL4A2 527
COL22A1 -2030
COLEC10 -2343
EMID1 -6378
COL8A1 -7143


GO:0140664 ATP-dependent DNA damage sensor activity
set GO:0140664 ATP-dependent DNA damage sensor activity
setSize 14
pANOVA 0.00734
s.dist -0.414
p.adjustANOVA 0.123


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51B -7158
SGF29 -7065
XRCC3 -6858
RAD51C -6005
RAD51D -4518
MSH2 -4089
MSH3 -4044
MLH1 -3603
MSH6 -2744
XRCC2 -2001
DMC1 -1476
PMS2 -1086
PMS1 3450
MLH3 4325

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51B -7158
SGF29 -7065
XRCC3 -6858
RAD51C -6005
RAD51D -4518
MSH2 -4089
MSH3 -4044
MLH1 -3603
MSH6 -2744
XRCC2 -2001
DMC1 -1476
PMS2 -1086
PMS1 3450
MLH3 4325


GO:0007611 learning or memory
set GO:0007611 learning or memory
setSize 15
pANOVA 0.00594
s.dist 0.41
p.adjustANOVA 0.104


Top enriched genes
Top 20 genes
GeneID Gene Rank
EGFR 7106
SLC11A2 6205
EP300 4671
ZNF385A 4567
TTBK1 3752
FZD9 3684
ARL6IP5 3349
PRKAR1B 3279
GM2A 2990
PAFAH1B1 2268
PICALM 1725
NEDD9 1167
B2M 627
AFF2 -502
NCSTN -773

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EGFR 7106
SLC11A2 6205
EP300 4671
ZNF385A 4567
TTBK1 3752
FZD9 3684
ARL6IP5 3349
PRKAR1B 3279
GM2A 2990
PAFAH1B1 2268
PICALM 1725
NEDD9 1167
B2M 627
AFF2 -502
NCSTN -773


GO:0006270 DNA replication initiation
set GO:0006270 DNA replication initiation
setSize 19
pANOVA 0.002
s.dist -0.41
p.adjustANOVA 0.0538


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLA2 -7146
MCM4 -6737
ORC2 -6575
ORC5 -6080
ORC4 -5767
CDC45 -5653
ORC6 -5459
MCM6 -5347
MCM2 -5199
CCNE1 -4962
PRIM2 -4687
CDC6 -2727
MCM5 -2094
TOPBP1 -1632
ORC3 591
CCNE2 1073
NOC3L 1444
PRIM1 3082
MCM10 6306

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA2 -7146
MCM4 -6737
ORC2 -6575
ORC5 -6080
ORC4 -5767
CDC45 -5653
ORC6 -5459
MCM6 -5347
MCM2 -5199
CCNE1 -4962
PRIM2 -4687
CDC6 -2727
MCM5 -2094
TOPBP1 -1632
ORC3 591
CCNE2 1073
NOC3L 1444
PRIM1 3082
MCM10 6306


GO:0004402 histone acetyltransferase activity
set GO:0004402 histone acetyltransferase activity
setSize 11
pANOVA 0.0195
s.dist 0.407
p.adjustANOVA 0.224


Top enriched genes
Top 20 genes
GeneID Gene Rank
TAF9 5736
CLOCK 5506
CREBBP 5138
TAF10 5019
EP300 4671
KAT14 3310
PHF10 3220
NCOA3 1229
NAA60 1154
METTL8 -1264
TAF1 -1636

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 5736
CLOCK 5506
CREBBP 5138
TAF10 5019
EP300 4671
KAT14 3310
PHF10 3220
NCOA3 1229
NAA60 1154
METTL8 -1264
TAF1 -1636


GO:0000159 protein phosphatase type 2A complex
set GO:0000159 protein phosphatase type 2A complex
setSize 12
pANOVA 0.015
s.dist -0.406
p.adjustANOVA 0.194


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP2R2B -7150
PPP2R5D -7029
PPP2R2A -6768
PPP2R5C -5841
PTPA -5764
PPP2CB -4976
PPP2CA -2925
PPP2R5A -2124
PPP2R3A -301
PPP2R2D 16
PPP2R5E 1967
NKD1 4860

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R2B -7150
PPP2R5D -7029
PPP2R2A -6768
PPP2R5C -5841
PTPA -5764
PPP2CB -4976
PPP2CA -2925
PPP2R5A -2124
PPP2R3A -301
PPP2R2D 16
PPP2R5E 1967
NKD1 4860


GO:0006310 DNA recombination
set GO:0006310 DNA recombination
setSize 23
pANOVA 0.000859
s.dist -0.402
p.adjustANOVA 0.0328


Top enriched genes
Top 20 genes
GeneID Gene Rank
RUVBL1 -7282
LIG1 -7263
HMGB2 -7058
EXO1 -6716
TOP3A -6590
XRCC6 -6500
ACTR8 -6428
XRCC5 -6329
EME1 -6292
TOP3B -6225
RDM1 -6192
PIF1 -5585
NSMCE1 -4686
SUPV3L1 -4596
HDGFRP2 -2998
RECQL -2753
SMC5 648
ACTR5 1675
WRN 2377
NSMCE4A 3924

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUVBL1 -7282
LIG1 -7263
HMGB2 -7058
EXO1 -6716
TOP3A -6590
XRCC6 -6500
ACTR8 -6428
XRCC5 -6329
EME1 -6292
TOP3B -6225
RDM1 -6192
PIF1 -5585
NSMCE1 -4686
SUPV3L1 -4596
HDGFRP2 -2998
RECQL -2753
SMC5 648
ACTR5 1675
WRN 2377
NSMCE4A 3924
DCLRE1C 4673
LIG3 5148
EME2 6729


GO:0034605 cellular response to heat
set GO:0034605 cellular response to heat
setSize 16
pANOVA 0.00563
s.dist -0.4
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
YWHAE -6581
HSP90AA1 -6441
HTRA2 -5632
SLC52A3 -5515
DHX36 -5359
HMOX1 -4954
DNAJB1 -4842
PDCD6 -3224
SLU7 -2857
HSF1 -2791
HSF3 -2510
CDK1 -1667
HIKESHI -789
BAG3 -691
SUMO1 976
IER5 5524

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YWHAE -6581
HSP90AA1 -6441
HTRA2 -5632
SLC52A3 -5515
DHX36 -5359
HMOX1 -4954
DNAJB1 -4842
PDCD6 -3224
SLU7 -2857
HSF1 -2791
HSF3 -2510
CDK1 -1667
HIKESHI -789
BAG3 -691
SUMO1 976
IER5 5524


GO:0003899 DNA-directed 5’-3’ RNA polymerase activity
set GO:0003899 DNA-directed 5’-3’ RNA polymerase activity
setSize 10
pANOVA 0.0301
s.dist -0.396
p.adjustANOVA 0.292


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLRMT -7205
POLR3B -6695
POLR3K -4913
POLR2I -4017
POLR1B -3788
POLR3H -3584
POLR2H -2110
POLR3A -172
POLR2B 691
POLR2F 2451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLRMT -7205
POLR3B -6695
POLR3K -4913
POLR2I -4017
POLR1B -3788
POLR3H -3584
POLR2H -2110
POLR3A -172
POLR2B 691
POLR2F 2451


GO:0001818 negative regulation of cytokine production
set GO:0001818 negative regulation of cytokine production
setSize 11
pANOVA 0.0235
s.dist -0.394
p.adjustANOVA 0.251


Top enriched genes
Top 20 genes
GeneID Gene Rank
HDAC9 -6395
NPTN -6201
TIA1 -6133
RNF128 -5236
ATP2B1 -4453
N4BP1 -3414
MERTK -2337
TWSG1 -938
BTK -19
LGR4 1387
CASP3 1602

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HDAC9 -6395
NPTN -6201
TIA1 -6133
RNF128 -5236
ATP2B1 -4453
N4BP1 -3414
MERTK -2337
TWSG1 -938
BTK -19
LGR4 1387
CASP3 1602


GO:0005852 eukaryotic translation initiation factor 3 complex
set GO:0005852 eukaryotic translation initiation factor 3 complex
setSize 10
pANOVA 0.033
s.dist -0.389
p.adjustANOVA 0.306


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3J -7080
EIF3B -6973
EIF3F -6573
EIF3G -4206
EIF3H -4016
EIF3D -1826
EIF3E -1764
EIF3K -1720
EIF3L 1405
EIF3M 3904

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J -7080
EIF3B -6973
EIF3F -6573
EIF3G -4206
EIF3H -4016
EIF3D -1826
EIF3E -1764
EIF3K -1720
EIF3L 1405
EIF3M 3904


GO:0045505 dynein intermediate chain binding
set GO:0045505 dynein intermediate chain binding
setSize 18
pANOVA 0.00426
s.dist 0.389
p.adjustANOVA 0.085


Top enriched genes
Top 20 genes
GeneID Gene Rank
HTT 7215
DYNC2H1 6976
DNAH3 6689
HOOK3 6684
DNAH10 6515
DYNC1H1 6400
DYNLT1 6318
DNAH9 4938
DNAH12 4208
DYL1 4016
DNAAF5 3102
DNAH7 2269
DNAH8 1777
FRRS1L 554
DYNLRB1 -2767
DYNLT3 -3473
DNAH17 -4014
DYNLL2 -7247

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HTT 7215
DYNC2H1 6976
DNAH3 6689
HOOK3 6684
DNAH10 6515
DYNC1H1 6400
DYNLT1 6318
DNAH9 4938
DNAH12 4208
DYL1 4016
DNAAF5 3102
DNAH7 2269
DNAH8 1777
FRRS1L 554
DYNLRB1 -2767
DYNLT3 -3473
DNAH17 -4014
DYNLL2 -7247


GO:0006413 translational initiation
set GO:0006413 translational initiation
setSize 30
pANOVA 0.000233
s.dist -0.388
p.adjustANOVA 0.021


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF5B -7301
EIF3B -6973
EIF3F -6573
EIF4H -6543
EIF2A -6496
MTIF2 -5971
EIF4G2 -5655
EIF5 -5551
EIF4E -5423
MTIF3 -5179
EIF2S1 -4937
EIF4E2 -4814
ABCE1 -4581
EIF1AX -4190
EIF3H -4016
DHX33 -3713
EIF1B -2837
EIF3D -1826
EIF3E -1764
EIF6 -1593

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF5B -7301
EIF3B -6973
EIF3F -6573
EIF4H -6543
EIF2A -6496
MTIF2 -5971
EIF4G2 -5655
EIF5 -5551
EIF4E -5423
MTIF3 -5179
EIF2S1 -4937
EIF4E2 -4814
ABCE1 -4581
EIF1AX -4190
EIF3H -4016
DHX33 -3713
EIF1B -2837
EIF3D -1826
EIF3E -1764
EIF6 -1593
MTFMT -1299
EIF4E3 -207
EIF4A2 -60
EIF2B2 -54
EIF4G1 632
LARP1 692
EIF4G3 1118
EIF3L 1405
EIF2B1 2253
EIF1 5289


GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
set GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
setSize 34
pANOVA 9.29e-05
s.dist 0.387
p.adjustANOVA 0.0169


Top enriched genes
Top 20 genes
GeneID Gene Rank
ULK1 7102
MTOR 7057
PIM3 7045
RAF1 6980
PRKDC 6863
MAPKAPK2 6797
SLK 6728
RPS6KA3 6320
EIF2AK3 6225
SMG1 6204
EIF2AK2 5502
SGK1 5275
BRAF 4664
CSNK1G1 4515
STK11 4334
RPS6KA5 4245
STK4 3764
CHEK1 3585
RIPK2 2804
LIMK1 2715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ULK1 7102
MTOR 7057
PIM3 7045
RAF1 6980
PRKDC 6863
MAPKAPK2 6797
SLK 6728
RPS6KA3 6320
EIF2AK3 6225
SMG1 6204
EIF2AK2 5502
SGK1 5275
BRAF 4664
CSNK1G1 4515
STK11 4334
RPS6KA5 4245
STK4 3764
CHEK1 3585
RIPK2 2804
LIMK1 2715
EIF2AK1 2622
PAK2 2475
SIK2 2462
EIF2AK4 490
LIMK2 -573
CSNK1E -1058
PAK1 -1275
STK10 -1641
STK40 -1749
TAOK3 -2212
CSNK2A1 -2264
CSNK1A1 -2722
MASTL -3910
ULK3 -5181


GO:0006268 DNA unwinding involved in DNA replication
set GO:0006268 DNA unwinding involved in DNA replication
setSize 14
pANOVA 0.0122
s.dist -0.387
p.adjustANOVA 0.176


Top enriched genes
Top 20 genes
GeneID Gene Rank
PURA -6979
MCM4 -6737
RPA1 -6710
CDC45 -5653
MCM6 -5347
MCM2 -5199
MCM3 -4846
RECQL -2753
MCM5 -2094
GINS1 -2088
SSBP1 1106
RECQL5 1320
WRN 2377
GINS3 3462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PURA -6979
MCM4 -6737
RPA1 -6710
CDC45 -5653
MCM6 -5347
MCM2 -5199
MCM3 -4846
RECQL -2753
MCM5 -2094
GINS1 -2088
SSBP1 1106
RECQL5 1320
WRN 2377
GINS3 3462


GO:0007004 telomere maintenance via telomerase
set GO:0007004 telomere maintenance via telomerase
setSize 11
pANOVA 0.0267
s.dist -0.386
p.adjustANOVA 0.27


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPA1 -6710
HSP90AA1 -6441
DKC1 -6343
XRCC5 -6329
PTGES3 -4585
HMBOX1 -3000
GAR1 -1179
TERF1 -621
PINX1 290
RAD50 949
POT1 2512

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA1 -6710
HSP90AA1 -6441
DKC1 -6343
XRCC5 -6329
PTGES3 -4585
HMBOX1 -3000
GAR1 -1179
TERF1 -621
PINX1 290
RAD50 949
POT1 2512


GO:0140823 histone H2BS36 kinase activity
set GO:0140823 histone H2BS36 kinase activity
setSize 31
pANOVA 2e-04
s.dist 0.386
p.adjustANOVA 0.021


Top enriched genes
Top 20 genes
GeneID Gene Rank
ULK1 7102
MTOR 7057
PIM3 7045
RAF1 6980
PRKDC 6863
MAPKAPK2 6797
SLK 6728
RPS6KA3 6320
PRKAA1 6228
SMG1 6204
SGK1 5275
BRAF 4664
CSNK1G1 4515
STK11 4334
RPS6KA5 4245
STK4 3764
CHEK1 3585
RIPK2 2804
LIMK1 2715
PAK2 2475

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ULK1 7102
MTOR 7057
PIM3 7045
RAF1 6980
PRKDC 6863
MAPKAPK2 6797
SLK 6728
RPS6KA3 6320
PRKAA1 6228
SMG1 6204
SGK1 5275
BRAF 4664
CSNK1G1 4515
STK11 4334
RPS6KA5 4245
STK4 3764
CHEK1 3585
RIPK2 2804
LIMK1 2715
PAK2 2475
SIK2 2462
LIMK2 -573
CSNK1E -1058
PAK1 -1275
STK10 -1641
STK40 -1749
TAOK3 -2212
CSNK2A1 -2264
CSNK1A1 -2722
MASTL -3910
ULK3 -5181


GO:0035994 response to muscle stretch
set GO:0035994 response to muscle stretch
setSize 10
pANOVA 0.035
s.dist 0.385
p.adjustANOVA 0.312


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAF1 6980
PXN 5783
GSN 4370
NFKB1 4197
FOS 3872
RYR2 2819
PIK3CA 2358
MAPK14 2082
PTK2 -2172
DMD -2702

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAF1 6980
PXN 5783
GSN 4370
NFKB1 4197
FOS 3872
RYR2 2819
PIK3CA 2358
MAPK14 2082
PTK2 -2172
DMD -2702


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.12.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] ggplot2_3.5.1               gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] UpSetR_1.4.0                beeswarm_0.4.0             
##  [9] kableExtra_1.4.0            eulerr_7.0.2               
## [11] mitch_1.19.2                MASS_7.3-61                
## [13] gplots_3.2.0                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         reshape2_1.4.4             
## [25] dplyr_1.1.4                 zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] tidyselect_1.2.1        viridisLite_0.4.2       farver_2.1.2           
##  [4] bitops_1.0-9            fastmap_1.2.0           promises_1.3.2         
##  [7] digest_0.6.37           mime_0.12               lifecycle_1.0.4        
## [10] polylabelr_0.3.0        magrittr_2.0.3          compiler_4.4.2         
## [13] rlang_1.1.4             sass_0.4.9              tools_4.4.2            
## [16] yaml_2.3.10             knitr_1.49              labeling_0.4.3         
## [19] S4Arrays_1.4.1          htmlwidgets_1.6.4       DelayedArray_0.30.1    
## [22] xml2_1.3.6              plyr_1.8.9              RColorBrewer_1.1-3     
## [25] abind_1.4-8             BiocParallel_1.38.0     KernSmooth_2.23-24     
## [28] withr_3.0.2             purrr_1.0.2             polyclip_1.10-7        
## [31] grid_4.4.2              caTools_1.18.3          xtable_1.8-4           
## [34] colorspace_2.1-1        scales_1.3.0            cli_3.6.3              
## [37] rmarkdown_2.29          crayon_1.5.3            generics_0.1.3         
## [40] rstudioapi_0.17.1       httr_1.4.7              cachem_1.1.0           
## [43] stringr_1.5.1           zlibbioc_1.50.0         parallel_4.4.2         
## [46] XVector_0.44.0          vctrs_0.6.5             Matrix_1.7-1           
## [49] jsonlite_1.8.9          systemfonts_1.1.0       locfit_1.5-9.10        
## [52] jquerylib_0.1.4         tidyr_1.3.1             glue_1.8.0             
## [55] ggstats_0.7.0           codetools_0.2-20        stringi_1.8.4          
## [58] gtable_0.3.6            later_1.4.1             UCSC.utils_1.0.0       
## [61] munsell_0.5.1           pillar_1.10.0           htmltools_0.5.8.1      
## [64] GenomeInfoDbData_1.2.12 R6_2.5.1                evaluate_1.0.1         
## [67] shiny_1.10.0            lattice_0.22-6          httpuv_1.6.15          
## [70] bslib_0.8.0             Rcpp_1.0.13-1           svglite_2.1.3          
## [73] gridExtra_2.3           SparseArray_1.4.8       xfun_0.49              
## [76] pkgconfig_2.0.3

END of report