date generated: 2025-01-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
stat
5_8S_rRNA -1.5369477
A4GALT 2.1302274
AAAS -0.5511747
AACS 0.1400057
AADAC -1.3996095
AADAT -0.2140769

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 5133
num_genes_in_profile 14434
duplicated_genes_present 0
num_profile_genes_in_sets 9191
num_profile_genes_not_in_sets 5243

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 5133
num_genesets_excluded 3362
num_genesets_included 1771

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
GO:0022625 cytosolic large ribosomal subunit 40 3.57e-20 0.840 2.11e-17
GO:0002181 cytoplasmic translation 27 2.13e-13 0.816 7.54e-11
GO:0022627 cytosolic small ribosomal subunit 25 4.06e-12 0.801 1.03e-09
GO:0035145 exon-exon junction complex 10 3.17e-05 -0.760 1.75e-03
GO:0140658 ATP-dependent chromatin remodeler activity 11 3.48e-05 -0.721 1.83e-03
GO:0003735 structural constituent of ribosome 118 6.52e-38 0.685 1.15e-34
GO:0008137 NADH dehydrogenase (ubiquinone) activity 10 2.98e-04 0.661 1.05e-02
GO:0045271 respiratory chain complex I 31 2.34e-10 0.657 4.60e-08
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 19 7.94e-07 0.654 7.41e-05
GO:0006749 glutathione metabolic process 15 1.38e-05 0.648 8.41e-04
GO:0004602 glutathione peroxidase activity 12 1.05e-04 0.647 4.53e-03
GO:0004364 glutathione transferase activity 10 5.09e-04 0.635 1.67e-02
GO:0006412 translation 96 6.03e-24 0.596 5.34e-21
GO:0000245 spliceosomal complex assembly 10 1.50e-03 -0.580 3.51e-02
GO:1902774 late endosome to lysosome transport 10 1.54e-03 0.578 3.51e-02
GO:1990391 DNA repair complex 10 1.72e-03 -0.573 3.80e-02
GO:0032981 mitochondrial respiratory chain complex I assembly 38 2.15e-09 0.561 3.80e-07
GO:0007042 lysosomal lumen acidification 10 2.30e-03 0.557 4.63e-02
GO:0045116 protein neddylation 10 2.45e-03 0.553 4.75e-02
GO:0098869 cellular oxidant detoxification 28 5.66e-07 0.546 5.57e-05
GO:0034314 Arp2/3 complex-mediated actin nucleation 11 2.18e-03 0.534 4.54e-02
GO:0042474 middle ear morphogenesis 10 3.72e-03 0.530 6.04e-02
GO:1903543 positive regulation of exosomal secretion 10 3.90e-03 0.527 6.23e-02
GO:0032585 multivesicular body membrane 12 1.64e-03 0.525 3.68e-02
GO:0005852 eukaryotic translation initiation factor 3 complex 10 4.18e-03 0.523 6.50e-02
GO:0030992 intraciliary transport particle B 15 6.84e-04 0.506 2.05e-02
GO:0005840 ribosome 43 1.16e-08 0.503 1.47e-06
GO:0001732 formation of cytoplasmic translation initiation complex 12 2.77e-03 0.499 5.21e-02
GO:0000422 autophagy of mitochondrion 14 1.35e-03 0.495 3.26e-02
GO:0019003 GDP binding 44 2.14e-08 0.488 2.52e-06
GO:0060047 heart contraction 10 7.79e-03 0.486 1.01e-01
GO:1905564 positive regulation of vascular endothelial cell proliferation 10 8.60e-03 0.480 1.08e-01
GO:0055074 calcium ion homeostasis 18 4.29e-04 0.479 1.46e-02
GO:0009888 tissue development 18 5.44e-04 -0.471 1.75e-02
GO:0022604 regulation of cell morphogenesis 14 2.40e-03 -0.469 4.73e-02
GO:1904294 positive regulation of ERAD pathway 10 1.03e-02 0.468 1.16e-01
GO:0004683 calcium/calmodulin-dependent protein kinase activity 11 7.53e-03 0.465 9.95e-02
GO:1903076 regulation of protein localization to plasma membrane 18 6.51e-04 0.464 1.99e-02
GO:0090443 FAR/SIN/STRIPAK complex 12 5.62e-03 0.462 8.12e-02
GO:0003925 G protein activity 18 7.16e-04 0.461 2.11e-02
GO:0070577 lysine-acetylated histone binding 16 1.55e-03 -0.457 3.51e-02
GO:0006744 ubiquinone biosynthetic process 11 8.77e-03 0.456 1.08e-01
GO:0016442 RISC complex 11 9.09e-03 -0.454 1.08e-01
GO:0036121 double-stranded DNA helicase activity 11 9.27e-03 -0.453 1.08e-01
GO:0030904 retromer complex 15 2.47e-03 0.451 4.75e-02
GO:0048041 focal adhesion assembly 14 3.54e-03 -0.450 5.88e-02
GO:0009378 four-way junction helicase activity 13 5.11e-03 -0.449 7.48e-02
GO:0051603 proteolysis involved in protein catabolic process 23 1.97e-04 0.448 7.44e-03
GO:0031663 lipopolysaccharide-mediated signaling pathway 11 1.07e-02 0.444 1.18e-01
GO:0030863 cortical cytoskeleton 10 1.52e-02 0.443 1.47e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
GO:0022625 cytosolic large ribosomal subunit 40 3.57e-20 0.840000 2.11e-17
GO:0002181 cytoplasmic translation 27 2.13e-13 0.816000 7.54e-11
GO:0022627 cytosolic small ribosomal subunit 25 4.06e-12 0.801000 1.03e-09
GO:0035145 exon-exon junction complex 10 3.17e-05 -0.760000 1.75e-03
GO:0140658 ATP-dependent chromatin remodeler activity 11 3.48e-05 -0.721000 1.83e-03
GO:0003735 structural constituent of ribosome 118 6.52e-38 0.685000 1.15e-34
GO:0008137 NADH dehydrogenase (ubiquinone) activity 10 2.98e-04 0.661000 1.05e-02
GO:0045271 respiratory chain complex I 31 2.34e-10 0.657000 4.60e-08
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 19 7.94e-07 0.654000 7.41e-05
GO:0006749 glutathione metabolic process 15 1.38e-05 0.648000 8.41e-04
GO:0004602 glutathione peroxidase activity 12 1.05e-04 0.647000 4.53e-03
GO:0004364 glutathione transferase activity 10 5.09e-04 0.635000 1.67e-02
GO:0006412 translation 96 6.03e-24 0.596000 5.34e-21
GO:0000245 spliceosomal complex assembly 10 1.50e-03 -0.580000 3.51e-02
GO:1902774 late endosome to lysosome transport 10 1.54e-03 0.578000 3.51e-02
GO:1990391 DNA repair complex 10 1.72e-03 -0.573000 3.80e-02
GO:0032981 mitochondrial respiratory chain complex I assembly 38 2.15e-09 0.561000 3.80e-07
GO:0007042 lysosomal lumen acidification 10 2.30e-03 0.557000 4.63e-02
GO:0045116 protein neddylation 10 2.45e-03 0.553000 4.75e-02
GO:0098869 cellular oxidant detoxification 28 5.66e-07 0.546000 5.57e-05
GO:0034314 Arp2/3 complex-mediated actin nucleation 11 2.18e-03 0.534000 4.54e-02
GO:0042474 middle ear morphogenesis 10 3.72e-03 0.530000 6.04e-02
GO:1903543 positive regulation of exosomal secretion 10 3.90e-03 0.527000 6.23e-02
GO:0032585 multivesicular body membrane 12 1.64e-03 0.525000 3.68e-02
GO:0005852 eukaryotic translation initiation factor 3 complex 10 4.18e-03 0.523000 6.50e-02
GO:0030992 intraciliary transport particle B 15 6.84e-04 0.506000 2.05e-02
GO:0005840 ribosome 43 1.16e-08 0.503000 1.47e-06
GO:0001732 formation of cytoplasmic translation initiation complex 12 2.77e-03 0.499000 5.21e-02
GO:0000422 autophagy of mitochondrion 14 1.35e-03 0.495000 3.26e-02
GO:0019003 GDP binding 44 2.14e-08 0.488000 2.52e-06
GO:0060047 heart contraction 10 7.79e-03 0.486000 1.01e-01
GO:1905564 positive regulation of vascular endothelial cell proliferation 10 8.60e-03 0.480000 1.08e-01
GO:0055074 calcium ion homeostasis 18 4.29e-04 0.479000 1.46e-02
GO:0009888 tissue development 18 5.44e-04 -0.471000 1.75e-02
GO:0022604 regulation of cell morphogenesis 14 2.40e-03 -0.469000 4.73e-02
GO:1904294 positive regulation of ERAD pathway 10 1.03e-02 0.468000 1.16e-01
GO:0004683 calcium/calmodulin-dependent protein kinase activity 11 7.53e-03 0.465000 9.95e-02
GO:1903076 regulation of protein localization to plasma membrane 18 6.51e-04 0.464000 1.99e-02
GO:0090443 FAR/SIN/STRIPAK complex 12 5.62e-03 0.462000 8.12e-02
GO:0003925 G protein activity 18 7.16e-04 0.461000 2.11e-02
GO:0070577 lysine-acetylated histone binding 16 1.55e-03 -0.457000 3.51e-02
GO:0006744 ubiquinone biosynthetic process 11 8.77e-03 0.456000 1.08e-01
GO:0016442 RISC complex 11 9.09e-03 -0.454000 1.08e-01
GO:0036121 double-stranded DNA helicase activity 11 9.27e-03 -0.453000 1.08e-01
GO:0030904 retromer complex 15 2.47e-03 0.451000 4.75e-02
GO:0048041 focal adhesion assembly 14 3.54e-03 -0.450000 5.88e-02
GO:0009378 four-way junction helicase activity 13 5.11e-03 -0.449000 7.48e-02
GO:0051603 proteolysis involved in protein catabolic process 23 1.97e-04 0.448000 7.44e-03
GO:0031663 lipopolysaccharide-mediated signaling pathway 11 1.07e-02 0.444000 1.18e-01
GO:0030863 cortical cytoskeleton 10 1.52e-02 0.443000 1.47e-01
GO:0018279 protein N-linked glycosylation via asparagine 11 1.11e-02 0.442000 1.20e-01
GO:0051642 centrosome localization 14 4.22e-03 0.442000 6.50e-02
GO:0042073 intraciliary transport 16 2.25e-03 0.441000 4.58e-02
GO:0030150 protein import into mitochondrial matrix 12 8.25e-03 0.440000 1.06e-01
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 24 1.93e-04 -0.440000 7.44e-03
GO:0005544 calcium-dependent phospholipid binding 21 4.97e-04 0.439000 1.66e-02
GO:1903077 negative regulation of protein localization to plasma membrane 14 4.51e-03 0.438000 6.76e-02
GO:0060379 cardiac muscle cell myoblast differentiation 10 1.66e-02 -0.437000 1.53e-01
GO:0005762 mitochondrial large ribosomal subunit 38 3.63e-06 0.434000 2.57e-04
GO:0033290 eukaryotic 48S preinitiation complex 13 6.82e-03 0.433000 9.27e-02
GO:0008593 regulation of Notch signaling pathway 10 1.82e-02 0.431000 1.58e-01
GO:0031468 nuclear membrane reassembly 11 1.34e-02 0.431000 1.36e-01
GO:0070034 telomerase RNA binding 12 1.00e-02 -0.429000 1.13e-01
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 11 1.39e-02 0.428000 1.39e-01
GO:0031681 G-protein beta-subunit binding 10 1.93e-02 0.427000 1.62e-01
GO:0032391 photoreceptor connecting cilium 18 1.82e-03 0.425000 3.96e-02
GO:0005763 mitochondrial small ribosomal subunit 21 7.69e-04 0.424000 2.20e-02
GO:0031466 Cul5-RING ubiquitin ligase complex 11 1.50e-02 0.424000 1.47e-01
GO:0001675 acrosome assembly 11 1.58e-02 0.420000 1.49e-01
GO:0044322 endoplasmic reticulum quality control compartment 11 1.59e-02 0.420000 1.49e-01
GO:0005665 RNA polymerase II, core complex 10 2.20e-02 0.418000 1.78e-01
GO:0012506 vesicle membrane 16 4.35e-03 0.412000 6.59e-02
GO:0046961 proton-transporting ATPase activity, rotational mechanism 14 8.48e-03 0.406000 1.07e-01
GO:0035278 miRNA-mediated gene silencing by inhibition of translation 13 1.14e-02 -0.405000 1.22e-01
GO:0005828 kinetochore microtubule 10 2.71e-02 0.404000 2.01e-01
GO:0060395 SMAD protein signal transduction 14 9.30e-03 -0.401000 1.08e-01
GO:0051537 2 iron, 2 sulfur cluster binding 17 4.19e-03 0.401000 6.50e-02
GO:0002218 activation of innate immune response 17 5.07e-03 -0.393000 7.48e-02
GO:0061952 midbody abscission 14 1.11e-02 0.392000 1.20e-01
GO:0051287 NAD binding 19 3.13e-03 0.392000 5.54e-02
GO:0005771 multivesicular body 21 1.91e-03 0.391000 4.08e-02
GO:0005049 nuclear export signal receptor activity 10 3.30e-02 -0.389000 2.27e-01
GO:0032968 positive regulation of transcription elongation by RNA polymerase II 15 9.14e-03 -0.389000 1.08e-01
GO:0032924 activin receptor signaling pathway 12 1.99e-02 -0.388000 1.65e-01
GO:0061749 forked DNA-dependent helicase activity 10 3.46e-02 -0.386000 2.32e-01
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 35 8.33e-05 0.384000 3.70e-03
GO:0141198 protein branched polyubiquitination 13 1.70e-02 -0.382000 1.54e-01
GO:0061631 ubiquitin conjugating enzyme activity 24 1.20e-03 0.382000 2.99e-02
GO:0071353 cellular response to interleukin-4 11 2.90e-02 0.380000 2.11e-01
GO:0044295 axonal growth cone 10 3.83e-02 -0.378000 2.43e-01
GO:0042407 cristae formation 11 3.15e-02 0.375000 2.23e-01
GO:0017166 vinculin binding 10 4.29e-02 -0.370000 2.56e-01
GO:0031929 TOR signaling 14 1.66e-02 0.370000 1.53e-01
GO:0043995 histone H4K5 acetyltransferase activity 10 4.34e-02 -0.369000 2.56e-01
GO:0043996 histone H4K8 acetyltransferase activity 10 4.34e-02 -0.369000 2.56e-01
GO:0006468 protein phosphorylation 12 2.69e-02 -0.369000 2.01e-01
GO:0016236 macroautophagy 16 1.08e-02 0.368000 1.18e-01
GO:0070182 DNA polymerase binding 13 2.18e-02 -0.368000 1.77e-01
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 18 6.97e-03 0.367000 9.35e-02
GO:0071816 tail-anchored membrane protein insertion into ER membrane 10 4.49e-02 0.366000 2.61e-01
GO:0016226 iron-sulfur cluster assembly 17 9.07e-03 0.366000 1.08e-01
GO:0035925 mRNA 3’-UTR AU-rich region binding 13 2.25e-02 0.365000 1.80e-01
GO:0030665 clathrin-coated vesicle membrane 11 3.61e-02 0.365000 2.39e-01
GO:0050768 negative regulation of neurogenesis 10 4.73e-02 -0.362000 2.69e-01
GO:0015908 fatty acid transport 11 3.84e-02 0.361000 2.43e-01
GO:0030127 COPII vesicle coat 10 4.86e-02 0.360000 2.74e-01
GO:0043997 histone H4K12 acetyltransferase activity 10 4.89e-02 -0.360000 2.75e-01
GO:0001772 immunological synapse 23 2.86e-03 0.359000 5.28e-02
GO:0042056 chemoattractant activity 11 3.93e-02 0.359000 2.46e-01
GO:0003724 RNA helicase activity 37 1.63e-04 -0.358000 6.56e-03
GO:0016282 eukaryotic 43S preinitiation complex 14 2.03e-02 0.358000 1.67e-01
GO:1904646 cellular response to amyloid-beta 10 5.09e-02 0.357000 2.78e-01
GO:1904019 epithelial cell apoptotic process 13 2.66e-02 0.355000 1.99e-01
GO:0008089 anterograde axonal transport 10 5.22e-02 0.355000 2.82e-01
GO:0008320 protein transmembrane transporter activity 11 4.31e-02 0.352000 2.56e-01
GO:0097352 autophagosome maturation 23 3.56e-03 0.351000 5.88e-02
GO:0001958 endochondral ossification 15 1.93e-02 0.349000 1.62e-01
GO:0001508 action potential 10 5.62e-02 -0.349000 2.93e-01
GO:0043408 regulation of MAPK cascade 21 5.68e-03 -0.349000 8.12e-02
GO:0006487 protein N-linked glycosylation 29 1.17e-03 0.348000 2.99e-02
GO:2000648 positive regulation of stem cell proliferation 12 3.93e-02 0.344000 2.46e-01
GO:0045454 cell redox homeostasis 20 7.96e-03 0.343000 1.03e-01
GO:0043425 bHLH transcription factor binding 10 6.15e-02 -0.342000 3.08e-01
GO:1900181 negative regulation of protein localization to nucleus 11 5.02e-02 -0.341000 2.76e-01
GO:0007017 microtubule-based process 11 5.03e-02 0.341000 2.76e-01
GO:0006979 response to oxidative stress 50 3.07e-05 0.341000 1.75e-03
GO:0006337 nucleosome disassembly 10 6.21e-02 -0.341000 3.10e-01
GO:0005743 mitochondrial inner membrane 181 3.09e-15 0.340000 1.37e-12
GO:0071011 precatalytic spliceosome 12 4.28e-02 0.338000 2.56e-01
GO:0043296 apical junction complex 10 6.49e-02 -0.337000 3.17e-01
GO:0016514 SWI/SNF complex 20 9.23e-03 -0.336000 1.08e-01
GO:0009653 anatomical structure morphogenesis 22 6.41e-03 -0.336000 8.86e-02
GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction 14 2.98e-02 0.335000 2.16e-01
GO:0000793 condensed chromosome 13 3.80e-02 -0.332000 2.43e-01
GO:0005758 mitochondrial intermembrane space 47 8.23e-05 0.332000 3.70e-03
GO:0006623 protein targeting to vacuole 11 5.68e-02 -0.332000 2.93e-01
GO:0030574 collagen catabolic process 10 7.03e-02 0.331000 3.27e-01
GO:0034727 piecemeal microautophagy of the nucleus 13 3.96e-02 0.330000 2.46e-01
GO:0031623 receptor internalization 21 9.11e-03 0.329000 1.08e-01
GO:0004896 cytokine receptor activity 19 1.31e-02 0.329000 1.35e-01
GO:0005795 Golgi stack 18 1.69e-02 0.325000 1.54e-01
GO:0140416 transcription regulator inhibitor activity 12 5.15e-02 -0.325000 2.80e-01
GO:0001819 positive regulation of cytokine production 13 4.32e-02 0.324000 2.56e-01
GO:0009060 aerobic respiration 10 7.65e-02 0.324000 3.41e-01
GO:0009615 response to virus 31 1.83e-03 0.323000 3.96e-02
GO:0019915 lipid storage 11 6.33e-02 0.323000 3.12e-01
GO:0051787 misfolded protein binding 12 5.38e-02 0.322000 2.88e-01
GO:2000377 regulation of reactive oxygen species metabolic process 10 7.88e-02 0.321000 3.41e-01
GO:0060170 ciliary membrane 19 1.58e-02 0.320000 1.49e-01
GO:0005902 microvillus 28 3.49e-03 0.319000 5.88e-02
GO:1990841 promoter-specific chromatin binding 34 1.31e-03 -0.319000 3.22e-02
GO:0045216 cell-cell junction organization 13 4.77e-02 -0.317000 2.70e-01
GO:0080008 Cul4-RING E3 ubiquitin ligase complex 13 4.90e-02 -0.315000 2.75e-01
GO:0005777 peroxisome 49 1.37e-04 0.315000 5.78e-03
GO:0017056 structural constituent of nuclear pore 19 1.75e-02 -0.315000 1.56e-01
GO:0070498 interleukin-1-mediated signaling pathway 11 7.05e-02 0.315000 3.27e-01
GO:0007492 endoderm development 10 8.50e-02 -0.315000 3.50e-01
GO:0005680 anaphase-promoting complex 13 5.14e-02 -0.312000 2.80e-01
GO:0097730 non-motile cilium 14 4.32e-02 0.312000 2.56e-01
GO:0030968 endoplasmic reticulum unfolded protein response 30 3.21e-03 0.311000 5.63e-02
GO:0070507 regulation of microtubule cytoskeleton organization 15 3.72e-02 0.311000 2.40e-01
GO:0000723 telomere maintenance 29 3.82e-03 -0.310000 6.15e-02
GO:0005044 scavenger receptor activity 10 8.96e-02 0.310000 3.57e-01
GO:0015701 bicarbonate transport 11 7.51e-02 -0.310000 3.38e-01
GO:0004386 helicase activity 40 7.47e-04 -0.308000 2.17e-02
GO:0009791 post-embryonic development 37 1.18e-03 -0.308000 2.99e-02
GO:0005811 lipid droplet 42 6.09e-04 0.306000 1.93e-02
GO:0090128 regulation of synapse maturation 10 9.42e-02 0.306000 3.64e-01
GO:0048306 calcium-dependent protein binding 20 1.81e-02 0.305000 1.58e-01
GO:0000423 mitophagy 31 3.42e-03 0.304000 5.88e-02
GO:0006094 gluconeogenesis 20 1.93e-02 0.302000 1.62e-01
GO:0043409 negative regulation of MAPK cascade 20 1.97e-02 -0.301000 1.64e-01
GO:0032728 positive regulation of interferon-beta production 15 4.37e-02 -0.301000 2.57e-01
GO:0001725 stress fiber 42 7.89e-04 -0.299000 2.22e-02
GO:0005249 voltage-gated potassium channel activity 15 4.50e-02 -0.299000 2.61e-01
GO:0003678 DNA helicase activity 20 2.07e-02 -0.299000 1.70e-01
GO:0090110 COPII-coated vesicle cargo loading 10 1.02e-01 0.299000 3.78e-01
GO:0004860 protein kinase inhibitor activity 19 2.43e-02 0.299000 1.89e-01
GO:0071711 basement membrane organization 12 7.36e-02 0.298000 3.34e-01
GO:0016829 lyase activity 15 4.59e-02 0.298000 2.62e-01
GO:0015035 protein-disulfide reductase activity 14 5.38e-02 0.298000 2.88e-01
GO:0031982 vesicle 26 8.73e-03 0.297000 1.08e-01
GO:0070411 I-SMAD binding 11 8.84e-02 -0.297000 3.57e-01
GO:0060349 bone morphogenesis 12 7.69e-02 0.295000 3.41e-01
GO:0045177 apical part of cell 34 3.07e-03 0.294000 5.54e-02
GO:0044344 cellular response to fibroblast growth factor stimulus 10 1.09e-01 0.293000 3.95e-01
GO:0044458 motile cilium assembly 12 7.99e-02 0.292000 3.42e-01
GO:0007162 negative regulation of cell adhesion 17 3.72e-02 -0.292000 2.40e-01
GO:0031669 cellular response to nutrient levels 13 6.87e-02 -0.292000 3.25e-01
GO:0048701 embryonic cranial skeleton morphogenesis 13 6.87e-02 0.292000 3.25e-01
GO:0048812 neuron projection morphogenesis 30 5.85e-03 -0.291000 8.29e-02
GO:0005764 lysosome 132 9.32e-09 0.290000 1.27e-06
GO:0016491 oxidoreductase activity 47 6.31e-04 0.288000 1.96e-02
GO:0071333 cellular response to glucose stimulus 12 8.41e-02 -0.288000 3.49e-01
GO:0032757 positive regulation of interleukin-8 production 17 3.99e-02 0.288000 2.46e-01
GO:0051393 alpha-actinin binding 10 1.16e-01 -0.287000 4.00e-01
GO:0000242 pericentriolar material 14 6.29e-02 -0.287000 3.12e-01
GO:0035914 skeletal muscle cell differentiation 24 1.49e-02 -0.287000 1.47e-01
GO:0043122 regulation of canonical NF-kappaB signal transduction 18 3.59e-02 0.286000 2.39e-01
GO:0030170 pyridoxal phosphate binding 34 4.14e-03 0.284000 6.50e-02
GO:0002040 sprouting angiogenesis 18 3.68e-02 -0.284000 2.40e-01
GO:0005879 axonemal microtubule 10 1.20e-01 0.284000 4.06e-01
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 21 2.45e-02 -0.284000 1.90e-01
GO:0043484 regulation of RNA splicing 23 1.87e-02 -0.283000 1.60e-01
GO:0040029 epigenetic regulation of gene expression 18 3.76e-02 -0.283000 2.41e-01
GO:0090102 cochlea development 12 9.07e-02 0.282000 3.59e-01
GO:0008154 actin polymerization or depolymerization 11 1.07e-01 0.281000 3.89e-01
GO:0006099 tricarboxylic acid cycle 19 3.43e-02 0.281000 2.32e-01
GO:0000132 establishment of mitotic spindle orientation 26 1.34e-02 0.280000 1.36e-01
GO:0030020 extracellular matrix structural constituent conferring tensile strength 16 5.23e-02 0.280000 2.82e-01
GO:1902894 negative regulation of miRNA transcription 12 9.32e-02 -0.280000 3.64e-01
GO:0097060 synaptic membrane 10 1.25e-01 -0.280000 4.13e-01
GO:0060216 definitive hemopoiesis 10 1.26e-01 0.279000 4.14e-01
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 13 8.23e-02 0.278000 3.47e-01
GO:0050829 defense response to Gram-negative bacterium 12 9.56e-02 0.278000 3.64e-01
GO:0000307 cyclin-dependent protein kinase holoenzyme complex 21 2.76e-02 0.278000 2.04e-01
GO:0071897 DNA biosynthetic process 12 9.58e-02 -0.278000 3.64e-01
GO:0140672 ATAC complex 11 1.11e-01 -0.277000 3.97e-01
GO:0003007 heart morphogenesis 15 6.38e-02 -0.276000 3.14e-01
GO:0060045 positive regulation of cardiac muscle cell proliferation 13 8.47e-02 -0.276000 3.49e-01
GO:0035025 positive regulation of Rho protein signal transduction 10 1.31e-01 -0.276000 4.20e-01
GO:0007080 mitotic metaphase chromosome alignment 23 2.21e-02 0.276000 1.78e-01
GO:0030057 desmosome 11 1.14e-01 -0.275000 3.99e-01
GO:0051016 barbed-end actin filament capping 15 6.54e-02 0.275000 3.19e-01
GO:0031334 positive regulation of protein-containing complex assembly 17 5.00e-02 0.275000 2.76e-01
GO:0061512 protein localization to cilium 22 2.59e-02 0.274000 1.97e-01
GO:0098761 cellular response to interleukin-7 10 1.33e-01 0.274000 4.22e-01
GO:0031573 mitotic intra-S DNA damage checkpoint signaling 11 1.16e-01 -0.274000 4.00e-01
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 40 2.72e-03 0.274000 5.18e-02
GO:0032580 Golgi cisterna membrane 26 1.57e-02 0.274000 1.49e-01
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 18 4.55e-02 -0.272000 2.62e-01
GO:0004519 endonuclease activity 13 8.94e-02 -0.272000 3.57e-01
GO:0030900 forebrain development 20 3.52e-02 -0.272000 2.35e-01
GO:0070403 NAD+ binding 11 1.19e-01 0.272000 4.06e-01
GO:0097225 sperm midpiece 15 6.85e-02 0.272000 3.25e-01
GO:0035102 PRC1 complex 12 1.03e-01 -0.272000 3.81e-01
GO:0045931 positive regulation of mitotic cell cycle 14 7.89e-02 0.271000 3.41e-01
GO:0001516 prostaglandin biosynthetic process 10 1.39e-01 0.270000 4.29e-01
GO:0003281 ventricular septum development 16 6.13e-02 -0.270000 3.08e-01
GO:0020037 heme binding 51 8.63e-04 0.270000 2.39e-02
GO:0071108 protein K48-linked deubiquitination 15 7.09e-02 -0.269000 3.28e-01
GO:0009792 embryo development ending in birth or egg hatching 10 1.42e-01 -0.268000 4.33e-01
GO:0071560 cellular response to transforming growth factor beta stimulus 16 6.42e-02 0.267000 3.15e-01
GO:0005774 vacuolar membrane 10 1.44e-01 0.267000 4.34e-01
GO:0005782 peroxisomal matrix 10 1.44e-01 0.267000 4.34e-01
GO:0030855 epithelial cell differentiation 29 1.29e-02 0.267000 1.34e-01
GO:0038061 non-canonical NF-kappaB signal transduction 11 1.26e-01 -0.266000 4.14e-01
GO:0000149 SNARE binding 31 1.04e-02 0.266000 1.16e-01
GO:0046966 nuclear thyroid hormone receptor binding 15 7.51e-02 -0.265000 3.38e-01
GO:0030206 chondroitin sulfate biosynthetic process 11 1.28e-01 0.265000 4.15e-01
GO:0030134 COPII-coated ER to Golgi transport vesicle 21 3.65e-02 0.264000 2.40e-01
GO:0019843 rRNA binding 22 3.26e-02 0.263000 2.26e-01
GO:1990247 N6-methyladenosine-containing RNA reader activity 10 1.50e-01 -0.263000 4.42e-01
GO:0034045 phagophore assembly site membrane 12 1.15e-01 0.263000 3.99e-01
GO:0140588 chromatin looping 27 1.81e-02 -0.263000 1.58e-01
GO:0046854 phosphatidylinositol phosphate biosynthetic process 18 5.39e-02 -0.262000 2.88e-01
GO:0070006 metalloaminopeptidase activity 15 7.85e-02 0.262000 3.41e-01
GO:0006488 dolichol-linked oligosaccharide biosynthetic process 14 8.95e-02 0.262000 3.57e-01
GO:0044331 cell-cell adhesion mediated by cadherin 11 1.33e-01 0.262000 4.22e-01
GO:0000407 phagophore assembly site 20 4.28e-02 0.262000 2.56e-01
GO:0006396 RNA processing 21 3.83e-02 -0.261000 2.43e-01
GO:2000352 negative regulation of endothelial cell apoptotic process 15 8.03e-02 0.261000 3.42e-01
GO:0030316 osteoclast differentiation 28 1.70e-02 -0.261000 1.54e-01
GO:0000146 microfilament motor activity 19 5.00e-02 -0.260000 2.76e-01
GO:0043138 3’-5’ DNA helicase activity 10 1.56e-01 -0.259000 4.47e-01
GO:0072593 reactive oxygen species metabolic process 16 7.40e-02 0.258000 3.35e-01
GO:0003756 protein disulfide isomerase activity 10 1.59e-01 0.257000 4.51e-01
GO:0005978 glycogen biosynthetic process 11 1.40e-01 0.257000 4.31e-01
GO:0060038 cardiac muscle cell proliferation 12 1.24e-01 0.257000 4.10e-01
GO:0035994 response to muscle stretch 10 1.60e-01 -0.257000 4.53e-01
GO:0050661 NADP binding 15 8.54e-02 0.257000 3.50e-01
GO:0043616 keratinocyte proliferation 11 1.41e-01 0.256000 4.32e-01
GO:0022626 cytosolic ribosome 13 1.10e-01 -0.256000 3.95e-01
GO:0097038 perinuclear endoplasmic reticulum 10 1.61e-01 0.256000 4.54e-01
GO:0051781 positive regulation of cell division 13 1.10e-01 0.256000 3.95e-01
GO:0030030 cell projection organization 13 1.12e-01 0.255000 3.97e-01
GO:0030133 transport vesicle 23 3.44e-02 0.255000 2.32e-01
GO:0015914 phospholipid transport 25 2.80e-02 0.254000 2.06e-01
GO:0045943 positive regulation of transcription by RNA polymerase I 11 1.45e-01 -0.254000 4.35e-01
GO:0005759 mitochondrial matrix 119 1.83e-06 0.254000 1.35e-04
GO:0042572 retinol metabolic process 13 1.14e-01 0.253000 3.98e-01
GO:0061709 reticulophagy 15 8.95e-02 0.253000 3.57e-01
GO:0051881 regulation of mitochondrial membrane potential 15 8.96e-02 0.253000 3.57e-01
GO:0032008 positive regulation of TOR signaling 12 1.31e-01 0.252000 4.21e-01
GO:0061775 cohesin loader activity 24 3.29e-02 -0.252000 2.27e-01
GO:0004402 histone acetyltransferase activity 11 1.49e-01 -0.251000 4.42e-01
GO:0017147 Wnt-protein binding 18 6.65e-02 0.250000 3.22e-01
GO:0006891 intra-Golgi vesicle-mediated transport 18 6.65e-02 0.250000 3.22e-01
GO:0000077 DNA damage checkpoint signaling 26 2.81e-02 -0.249000 2.06e-01
GO:1902895 positive regulation of miRNA transcription 25 3.14e-02 -0.249000 2.23e-01
GO:0005201 extracellular matrix structural constituent 12 1.36e-01 -0.249000 4.25e-01
GO:0000774 adenyl-nucleotide exchange factor activity 12 1.37e-01 -0.248000 4.26e-01
GO:0016180 snRNA processing 10 1.75e-01 -0.248000 4.78e-01
GO:0003713 transcription coactivator activity 128 1.36e-06 -0.248000 1.04e-04
GO:0034707 chloride channel complex 10 1.76e-01 0.247000 4.78e-01
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 17 7.79e-02 -0.247000 3.41e-01
GO:0042327 positive regulation of phosphorylation 12 1.39e-01 0.247000 4.29e-01
GO:0000380 alternative mRNA splicing, via spliceosome 16 8.80e-02 -0.246000 3.56e-01
GO:0000421 autophagosome membrane 23 4.16e-02 0.245000 2.52e-01
GO:0051315 attachment of mitotic spindle microtubules to kinetochore 10 1.79e-01 0.245000 4.80e-01
GO:0071806 protein transmembrane transport 12 1.43e-01 0.244000 4.34e-01
GO:0000266 mitochondrial fission 10 1.82e-01 0.244000 4.82e-01
GO:0040014 regulation of multicellular organism growth 12 1.44e-01 0.244000 4.34e-01
GO:0051233 spindle midzone 17 8.26e-02 0.243000 3.47e-01
GO:0006635 fatty acid beta-oxidation 26 3.20e-02 0.243000 2.24e-01
GO:0051959 dynein light intermediate chain binding 17 8.33e-02 -0.243000 3.47e-01
GO:0043488 regulation of mRNA stability 16 9.31e-02 -0.243000 3.64e-01
GO:0043687 post-translational protein modification 19 6.84e-02 0.242000 3.25e-01
GO:0030513 positive regulation of BMP signaling pathway 19 6.88e-02 -0.241000 3.25e-01
GO:0090314 positive regulation of protein targeting to membrane 12 1.48e-01 0.241000 4.40e-01
GO:0106222 lncRNA binding 17 8.59e-02 -0.241000 3.51e-01
GO:0010718 positive regulation of epithelial to mesenchymal transition 26 3.38e-02 -0.241000 2.30e-01
GO:0032743 positive regulation of interleukin-2 production 16 9.63e-02 0.240000 3.64e-01
GO:0022904 respiratory electron transport chain 14 1.20e-01 0.240000 4.06e-01
GO:0098609 cell-cell adhesion 83 1.60e-04 -0.240000 6.56e-03
GO:0070372 regulation of ERK1 and ERK2 cascade 12 1.50e-01 -0.240000 4.43e-01
GO:0032496 response to lipopolysaccharide 37 1.18e-02 0.239000 1.25e-01
GO:0030140 trans-Golgi network transport vesicle 11 1.69e-01 0.239000 4.71e-01
GO:0010839 negative regulation of keratinocyte proliferation 14 1.22e-01 0.239000 4.09e-01
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 12 1.53e-01 0.238000 4.47e-01
GO:0001736 establishment of planar polarity 12 1.53e-01 0.238000 4.47e-01
GO:0051131 chaperone-mediated protein complex assembly 14 1.23e-01 0.238000 4.10e-01
GO:0016459 myosin complex 24 4.38e-02 -0.238000 2.57e-01
GO:0006376 mRNA splice site recognition 12 1.55e-01 -0.237000 4.47e-01
GO:0030041 actin filament polymerization 15 1.12e-01 0.237000 3.97e-01
GO:0050808 synapse organization 16 1.01e-01 -0.237000 3.76e-01
GO:0090543 Flemming body 14 1.25e-01 0.237000 4.13e-01
GO:0070064 proline-rich region binding 10 1.96e-01 -0.236000 4.96e-01
GO:0140584 chromatin extrusion motor activity 23 5.02e-02 -0.236000 2.76e-01
GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 23 5.02e-02 -0.236000 2.76e-01
GO:0140849 ATP-dependent H2AZ histone chaperone activity 23 5.02e-02 -0.236000 2.76e-01
GO:0016581 NuRD complex 10 1.97e-01 -0.236000 4.96e-01
GO:0008094 ATP-dependent activity, acting on DNA 11 1.78e-01 -0.235000 4.79e-01
GO:0006672 ceramide metabolic process 10 2.00e-01 0.234000 4.97e-01
GO:0031210 phosphatidylcholine binding 17 9.58e-02 0.233000 3.64e-01
GO:0019882 antigen processing and presentation 11 1.81e-01 0.233000 4.82e-01
GO:0045335 phagocytic vesicle 36 1.58e-02 0.232000 1.49e-01
GO:0005882 intermediate filament 20 7.23e-02 -0.232000 3.32e-01
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 11 1.83e-01 0.232000 4.84e-01
GO:0050770 regulation of axonogenesis 13 1.48e-01 -0.232000 4.40e-01
GO:0034332 adherens junction organization 11 1.85e-01 0.231000 4.87e-01
GO:0060976 coronary vasculature development 17 9.96e-02 -0.231000 3.72e-01
GO:0070161 anchoring junction 16 1.11e-01 -0.230000 3.97e-01
GO:0099523 presynaptic cytosol 11 1.87e-01 0.230000 4.89e-01
GO:0005977 glycogen metabolic process 13 1.52e-01 0.230000 4.46e-01
GO:0031145 anaphase-promoting complex-dependent catabolic process 14 1.38e-01 -0.229000 4.27e-01
GO:0000045 autophagosome assembly 52 4.30e-03 0.229000 6.57e-02
GO:0012507 ER to Golgi transport vesicle membrane 11 1.89e-01 0.229000 4.92e-01
GO:0007095 mitotic G2 DNA damage checkpoint signaling 30 3.07e-02 -0.228000 2.19e-01
GO:0072583 clathrin-dependent endocytosis 19 8.61e-02 0.227000 3.51e-01
GO:0005901 caveola 28 3.73e-02 0.227000 2.40e-01
GO:0000502 proteasome complex 13 1.56e-01 0.227000 4.47e-01
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 66 1.42e-03 0.227000 3.41e-02
GO:0030097 hemopoiesis 24 5.41e-02 0.227000 2.88e-01
GO:1990518 single-stranded 3’-5’ DNA helicase activity 11 1.94e-01 -0.226000 4.96e-01
GO:0043024 ribosomal small subunit binding 13 1.59e-01 -0.226000 4.51e-01
GO:0034599 cellular response to oxidative stress 44 9.78e-03 0.225000 1.12e-01
GO:0010212 response to ionizing radiation 24 5.63e-02 -0.225000 2.93e-01
GO:0034142 toll-like receptor 4 signaling pathway 15 1.32e-01 0.224000 4.22e-01
GO:0030018 Z disc 50 6.23e-03 -0.224000 8.68e-02
GO:0007608 sensory perception of smell 11 2.00e-01 0.223000 4.97e-01
GO:0033962 P-body assembly 14 1.49e-01 -0.223000 4.41e-01
GO:0035115 embryonic forelimb morphogenesis 16 1.23e-01 0.223000 4.10e-01
GO:0140693 molecular condensate scaffold activity 24 5.90e-02 -0.223000 3.00e-01
GO:0009306 protein secretion 20 8.54e-02 0.222000 3.50e-01
GO:0035198 miRNA binding 21 7.85e-02 -0.222000 3.41e-01
GO:0030742 GTP-dependent protein binding 13 1.67e-01 0.221000 4.67e-01
GO:0006413 translational initiation 30 3.61e-02 0.221000 2.39e-01
GO:0006334 nucleosome assembly 27 4.72e-02 -0.221000 2.69e-01
GO:0006986 response to unfolded protein 12 1.86e-01 0.221000 4.87e-01
GO:0016973 poly(A)+ mRNA export from nucleus 13 1.69e-01 -0.221000 4.70e-01
GO:0007601 visual perception 39 1.73e-02 0.220000 1.55e-01
GO:0031490 chromatin DNA binding 41 1.52e-02 -0.219000 1.47e-01
GO:0071346 cellular response to type II interferon 24 6.32e-02 0.219000 3.12e-01
GO:0032206 positive regulation of telomere maintenance 14 1.56e-01 -0.219000 4.47e-01
GO:0050729 positive regulation of inflammatory response 22 7.61e-02 0.218000 3.41e-01
GO:0090201 negative regulation of release of cytochrome c from mitochondria 11 2.10e-01 0.218000 5.16e-01
GO:0015631 tubulin binding 30 3.90e-02 0.218000 2.46e-01
GO:0051321 meiotic cell cycle 22 7.71e-02 -0.218000 3.41e-01
GO:0007163 establishment or maintenance of cell polarity 13 1.74e-01 0.218000 4.77e-01
GO:0071782 endoplasmic reticulum tubular network 12 1.92e-01 -0.218000 4.96e-01
GO:0046677 response to antibiotic 13 1.75e-01 0.217000 4.78e-01
GO:0008139 nuclear localization sequence binding 13 1.75e-01 -0.217000 4.78e-01
GO:0048821 erythrocyte development 15 1.46e-01 -0.217000 4.35e-01
GO:0030331 nuclear estrogen receptor binding 19 1.02e-01 -0.217000 3.77e-01
GO:0007612 learning 13 1.76e-01 -0.217000 4.78e-01
GO:0006338 chromatin remodeling 251 3.67e-09 -0.217000 5.41e-07
GO:0045070 positive regulation of viral genome replication 19 1.02e-01 -0.217000 3.78e-01
GO:0050918 positive chemotaxis 13 1.77e-01 0.217000 4.79e-01
GO:0035023 regulation of Rho protein signal transduction 16 1.34e-01 -0.217000 4.22e-01
GO:0032543 mitochondrial translation 22 7.91e-02 0.216000 3.41e-01
GO:0006096 glycolytic process 23 7.27e-02 0.216000 3.32e-01
GO:0003714 transcription corepressor activity 101 1.78e-04 -0.216000 7.02e-03
GO:0035979 histone H2AXS139 kinase activity 32 3.46e-02 -0.216000 2.32e-01
GO:0051592 response to calcium ion 20 9.56e-02 0.215000 3.64e-01
GO:0005604 basement membrane 43 1.47e-02 -0.215000 1.46e-01
GO:0006633 fatty acid biosynthetic process 22 8.09e-02 0.215000 3.43e-01
GO:2001235 positive regulation of apoptotic signaling pathway 17 1.25e-01 0.215000 4.13e-01
GO:0042393 histone binding 94 3.25e-04 -0.215000 1.13e-02
GO:0005198 structural molecule activity 37 2.39e-02 0.215000 1.87e-01
GO:0061484 hematopoietic stem cell homeostasis 11 2.18e-01 -0.215000 5.25e-01
GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site 16 1.38e-01 0.214000 4.28e-01
GO:0005975 carbohydrate metabolic process 49 9.90e-03 0.213000 1.12e-01
GO:0019221 cytokine-mediated signaling pathway 45 1.35e-02 0.213000 1.36e-01
GO:0003924 GTPase activity 177 1.08e-06 0.213000 9.49e-05
GO:0048027 mRNA 5’-UTR binding 19 1.08e-01 0.213000 3.93e-01
GO:0006913 nucleocytoplasmic transport 18 1.18e-01 -0.213000 4.05e-01
GO:0045600 positive regulation of fat cell differentiation 21 9.23e-02 0.212000 3.64e-01
GO:0010975 regulation of neuron projection development 17 1.30e-01 0.212000 4.19e-01
GO:0009408 response to heat 19 1.10e-01 -0.212000 3.95e-01
GO:1902018 negative regulation of cilium assembly 13 1.86e-01 -0.212000 4.87e-01
GO:0140662 ATP-dependent protein folding chaperone 23 7.89e-02 -0.212000 3.41e-01
GO:0022008 neurogenesis 31 4.16e-02 -0.212000 2.52e-01
GO:0032456 endocytic recycling 42 1.78e-02 0.211000 1.58e-01
GO:0003743 translation initiation factor activity 39 2.26e-02 0.211000 1.80e-01
GO:0140861 DNA repair-dependent chromatin remodeling 14 1.72e-01 -0.211000 4.75e-01
GO:0042733 embryonic digit morphogenesis 30 4.56e-02 0.211000 2.62e-01
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 15 1.57e-01 -0.211000 4.48e-01
GO:0032729 positive regulation of type II interferon production 22 8.72e-02 0.211000 3.55e-01
GO:0043495 protein-membrane adaptor activity 17 1.34e-01 0.210000 4.22e-01
GO:0090141 positive regulation of mitochondrial fission 16 1.46e-01 0.210000 4.37e-01
GO:0071526 semaphorin-plexin signaling pathway 23 8.29e-02 -0.209000 3.47e-01
GO:0034497 protein localization to phagophore assembly site 11 2.31e-01 0.209000 5.40e-01
GO:0032266 phosphatidylinositol-3-phosphate binding 32 4.12e-02 0.209000 2.52e-01
GO:0008542 visual learning 20 1.07e-01 0.208000 3.89e-01
GO:0060326 cell chemotaxis 27 6.11e-02 -0.208000 3.08e-01
GO:0001935 endothelial cell proliferation 12 2.12e-01 0.208000 5.18e-01
GO:0000775 chromosome, centromeric region 31 4.53e-02 0.208000 2.62e-01
GO:0015030 Cajal body 26 6.67e-02 -0.208000 3.22e-01
GO:0055038 recycling endosome membrane 43 1.85e-02 0.208000 1.59e-01
GO:1904115 axon cytoplasm 25 7.28e-02 0.207000 3.32e-01
GO:0033617 mitochondrial cytochrome c oxidase assembly 13 1.96e-01 0.207000 4.96e-01
GO:0034976 response to endoplasmic reticulum stress 33 3.98e-02 0.207000 2.46e-01
GO:0051480 regulation of cytosolic calcium ion concentration 13 1.97e-01 0.207000 4.96e-01
GO:0005834 heterotrimeric G-protein complex 19 1.20e-01 0.206000 4.06e-01
GO:0032508 DNA duplex unwinding 44 1.80e-02 -0.206000 1.58e-01
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 12 2.17e-01 0.206000 5.25e-01
GO:0032956 regulation of actin cytoskeleton organization 37 3.04e-02 0.206000 2.18e-01
GO:0150052 regulation of postsynapse assembly 13 1.99e-01 -0.206000 4.97e-01
GO:0007099 centriole replication 13 1.99e-01 0.206000 4.97e-01
GO:0035269 protein O-linked mannosylation 13 1.99e-01 -0.206000 4.97e-01
GO:0030658 transport vesicle membrane 13 2.00e-01 0.205000 4.97e-01
GO:0002224 toll-like receptor signaling pathway 16 1.55e-01 0.205000 4.47e-01
GO:2001222 regulation of neuron migration 10 2.62e-01 0.205000 5.78e-01
GO:0030670 phagocytic vesicle membrane 20 1.13e-01 0.205000 3.97e-01
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 13 2.01e-01 -0.205000 5.00e-01
GO:0048018 receptor ligand activity 18 1.35e-01 -0.204000 4.22e-01
GO:0098552 side of membrane 15 1.73e-01 0.203000 4.75e-01
GO:0071480 cellular response to gamma radiation 14 1.88e-01 -0.203000 4.91e-01
GO:0031491 nucleosome binding 25 7.89e-02 -0.203000 3.41e-01
GO:0046540 U4/U6 x U5 tri-snRNP complex 23 9.27e-02 0.203000 3.64e-01
GO:0005783 endoplasmic reticulum 429 8.00e-13 0.202000 2.36e-10
GO:0003148 outflow tract septum morphogenesis 12 2.25e-01 -0.202000 5.35e-01
GO:0045739 positive regulation of DNA repair 20 1.18e-01 -0.202000 4.05e-01
GO:0004888 transmembrane signaling receptor activity 23 9.45e-02 0.201000 3.64e-01
GO:0006886 intracellular protein transport 160 1.13e-05 0.201000 7.42e-04
GO:0032039 integrator complex 15 1.78e-01 -0.201000 4.79e-01
GO:0030225 macrophage differentiation 12 2.29e-01 0.201000 5.39e-01
GO:0030426 growth cone 41 2.64e-02 -0.200000 1.99e-01
GO:0060261 positive regulation of transcription initiation by RNA polymerase II 30 5.76e-02 -0.200000 2.95e-01
GO:0030234 enzyme regulator activity 14 1.95e-01 0.200000 4.96e-01
GO:0001917 photoreceptor inner segment 23 9.72e-02 0.200000 3.66e-01
GO:0071007 U2-type catalytic step 2 spliceosome 24 9.04e-02 0.200000 3.59e-01
GO:0000387 spliceosomal snRNP assembly 17 1.54e-01 0.200000 4.47e-01
GO:0140311 protein sequestering activity 18 1.42e-01 0.200000 4.33e-01
GO:0097194 execution phase of apoptosis 10 2.76e-01 0.199000 5.99e-01
GO:2000042 negative regulation of double-strand break repair via homologous recombination 16 1.69e-01 -0.199000 4.70e-01
GO:0000792 heterochromatin 19 1.34e-01 -0.199000 4.22e-01
GO:0004857 enzyme inhibitor activity 12 2.34e-01 -0.198000 5.46e-01
GO:0030163 protein catabolic process 31 5.62e-02 0.198000 2.93e-01
GO:0004677 DNA-dependent protein kinase activity 31 5.63e-02 -0.198000 2.93e-01
GO:0071889 14-3-3 protein binding 15 1.85e-01 -0.198000 4.87e-01
GO:0001530 lipopolysaccharide binding 13 2.19e-01 0.197000 5.25e-01
GO:0005694 chromosome 76 3.04e-03 -0.197000 5.54e-02
GO:0007129 homologous chromosome pairing at meiosis 13 2.19e-01 -0.197000 5.25e-01
GO:0006654 phosphatidic acid biosynthetic process 12 2.38e-01 -0.197000 5.49e-01
GO:0034704 calcium channel complex 10 2.83e-01 0.196000 6.04e-01
GO:0044782 cilium organization 12 2.42e-01 0.195000 5.55e-01
GO:0002039 p53 binding 44 2.56e-02 -0.195000 1.96e-01
GO:0007218 neuropeptide signaling pathway 16 1.79e-01 0.194000 4.80e-01
GO:1990244 histone H2AT120 kinase activity 31 6.27e-02 -0.193000 3.12e-01
GO:0015813 L-glutamate transmembrane transport 11 2.68e-01 -0.193000 5.86e-01
GO:0045190 isotype switching 13 2.29e-01 -0.193000 5.39e-01
GO:0035567 non-canonical Wnt signaling pathway 14 2.12e-01 0.193000 5.18e-01
GO:0030218 erythrocyte differentiation 29 7.27e-02 0.193000 3.32e-01
GO:0046907 intracellular transport 14 2.13e-01 0.192000 5.20e-01
GO:0050905 neuromuscular process 10 2.93e-01 0.192000 6.15e-01
GO:0070412 R-SMAD binding 13 2.31e-01 -0.192000 5.41e-01
GO:0007005 mitochondrion organization 62 9.22e-03 0.191000 1.08e-01
GO:0045505 dynein intermediate chain binding 18 1.60e-01 -0.191000 4.54e-01
GO:0006506 GPI anchor biosynthetic process 25 9.85e-02 0.191000 3.69e-01
GO:0031167 rRNA methylation 11 2.73e-01 0.191000 5.94e-01
GO:0044389 ubiquitin-like protein ligase binding 16 1.89e-01 0.190000 4.92e-01
GO:0030501 positive regulation of bone mineralization 14 2.19e-01 0.190000 5.25e-01
GO:0030141 secretory granule 18 1.65e-01 0.189000 4.63e-01
GO:0043240 Fanconi anaemia nuclear complex 11 2.78e-01 0.189000 6.00e-01
GO:0006629 lipid metabolic process 52 1.84e-02 0.189000 1.59e-01
GO:0031397 negative regulation of protein ubiquitination 33 6.04e-02 0.189000 3.06e-01
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 11 2.78e-01 0.189000 6.00e-01
GO:0031902 late endosome membrane 67 7.61e-03 0.189000 9.99e-02
GO:0046875 ephrin receptor binding 17 1.78e-01 0.189000 4.80e-01
GO:0000139 Golgi membrane 262 1.60e-07 0.189000 1.67e-05
GO:0003899 DNA-directed 5’-3’ RNA polymerase activity 10 3.02e-01 -0.188000 6.23e-01
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 15 2.07e-01 -0.188000 5.10e-01
GO:0043565 sequence-specific DNA binding 56 1.50e-02 -0.188000 1.47e-01
GO:0001750 photoreceptor outer segment 22 1.28e-01 0.188000 4.15e-01
GO:0001974 blood vessel remodeling 17 1.81e-01 0.187000 4.82e-01
GO:0045202 synapse 163 3.85e-05 0.187000 1.95e-03
GO:0032868 response to insulin 22 1.29e-01 -0.187000 4.19e-01
GO:0003887 DNA-directed DNA polymerase activity 16 1.96e-01 -0.187000 4.96e-01
GO:0030897 HOPS complex 10 3.07e-01 -0.187000 6.28e-01
GO:0003700 DNA-binding transcription factor activity 78 4.63e-03 -0.186000 6.90e-02
GO:0001818 negative regulation of cytokine production 11 2.88e-01 0.185000 6.12e-01
GO:0031175 neuron projection development 49 2.51e-02 -0.185000 1.94e-01
GO:0007611 learning or memory 15 2.15e-01 0.185000 5.23e-01
GO:0006865 amino acid transport 10 3.11e-01 -0.185000 6.33e-01
GO:0030970 retrograde protein transport, ER to cytosol 12 2.68e-01 0.185000 5.86e-01
GO:0061136 regulation of proteasomal protein catabolic process 11 2.89e-01 0.185000 6.12e-01
GO:0021987 cerebral cortex development 24 1.19e-01 0.184000 4.06e-01
GO:0005876 spindle microtubule 20 1.55e-01 0.184000 4.47e-01
GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 13 2.52e-01 -0.184000 5.68e-01
GO:0003682 chromatin binding 238 1.18e-06 -0.183000 9.49e-05
GO:0005525 GTP binding 212 4.57e-06 0.183000 3.11e-04
GO:0021915 neural tube development 17 1.91e-01 -0.183000 4.95e-01
GO:0010977 negative regulation of neuron projection development 18 1.80e-01 -0.183000 4.80e-01
GO:0005254 chloride channel activity 19 1.69e-01 0.182000 4.70e-01
GO:0001501 skeletal system development 34 6.65e-02 0.182000 3.22e-01
GO:0000781 chromosome, telomeric region 75 6.67e-03 -0.181000 9.16e-02
GO:0007596 blood coagulation 26 1.10e-01 0.181000 3.95e-01
GO:0048872 homeostasis of number of cells 14 2.41e-01 0.181000 5.54e-01
GO:2000378 negative regulation of reactive oxygen species metabolic process 10 3.23e-01 0.181000 6.42e-01
GO:0071277 cellular response to calcium ion 32 7.72e-02 0.181000 3.41e-01
GO:0097431 mitotic spindle pole 27 1.05e-01 -0.180000 3.84e-01
GO:0017124 SH3 domain binding 43 4.09e-02 0.180000 2.51e-01
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 19 1.76e-01 0.179000 4.78e-01
GO:0007052 mitotic spindle organization 34 7.06e-02 0.179000 3.27e-01
GO:0034237 protein kinase A regulatory subunit binding 15 2.30e-01 -0.179000 5.40e-01
GO:0004713 protein tyrosine kinase activity 35 6.73e-02 -0.179000 3.24e-01
GO:0061077 chaperone-mediated protein folding 16 2.16e-01 0.179000 5.24e-01
GO:0002062 chondrocyte differentiation 22 1.48e-01 0.178000 4.40e-01
GO:0048675 axon extension 15 2.34e-01 -0.178000 5.45e-01
GO:0031122 cytoplasmic microtubule organization 28 1.04e-01 -0.178000 3.82e-01
GO:0072518 Rho-dependent protein serine/threonine kinase activity 32 8.23e-02 -0.178000 3.47e-01
GO:0030199 collagen fibril organization 32 8.26e-02 0.177000 3.47e-01
GO:0071549 cellular response to dexamethasone stimulus 11 3.08e-01 0.177000 6.30e-01
GO:0030036 actin cytoskeleton organization 107 1.55e-03 -0.177000 3.51e-02
GO:1902600 proton transmembrane transport 60 1.79e-02 0.177000 1.58e-01
GO:0005905 clathrin-coated pit 30 9.39e-02 0.177000 3.64e-01
GO:0045814 negative regulation of gene expression, epigenetic 16 2.22e-01 -0.177000 5.29e-01
GO:0050870 positive regulation of T cell activation 14 2.53e-01 0.176000 5.68e-01
GO:0030136 clathrin-coated vesicle 29 1.01e-01 0.176000 3.77e-01
GO:0005246 calcium channel regulator activity 10 3.37e-01 -0.176000 6.59e-01
GO:0035402 histone H3T11 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0044022 histone H3S28 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0044023 histone H4S1 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0044024 histone H2AS1 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0044025 histone H2BS14 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0072371 histone H2AS121 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0140855 histone H3S57 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0140857 histone H3T45 kinase activity 30 9.63e-02 -0.175000 3.64e-01
GO:0030500 regulation of bone mineralization 12 2.93e-01 0.175000 6.16e-01
GO:0101031 protein folding chaperone complex 18 1.99e-01 0.175000 4.97e-01
GO:2000114 regulation of establishment of cell polarity 10 3.38e-01 0.175000 6.60e-01
GO:0005789 endoplasmic reticulum membrane 401 2.40e-09 0.174000 3.86e-07
GO:0044297 cell body 25 1.31e-01 0.174000 4.21e-01
GO:0006631 fatty acid metabolic process 34 7.88e-02 0.174000 3.41e-01
GO:0015031 protein transport 175 7.32e-05 0.174000 3.55e-03
GO:0031398 positive regulation of protein ubiquitination 40 5.70e-02 0.174000 2.93e-01
GO:0001540 amyloid-beta binding 28 1.12e-01 0.174000 3.97e-01
GO:0007389 pattern specification process 14 2.61e-01 0.174000 5.78e-01
GO:0000791 euchromatin 29 1.06e-01 -0.174000 3.86e-01
GO:0004181 metallocarboxypeptidase activity 13 2.83e-01 -0.172000 6.05e-01
GO:0060291 long-term synaptic potentiation 11 3.24e-01 -0.172000 6.43e-01
GO:0005637 nuclear inner membrane 24 1.46e-01 0.172000 4.35e-01
GO:0048009 insulin-like growth factor receptor signaling pathway 31 9.83e-02 -0.172000 3.69e-01
GO:0046849 bone remodeling 10 3.48e-01 -0.171000 6.71e-01
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 16 2.36e-01 0.171000 5.46e-01
GO:1904262 negative regulation of TORC1 signaling 28 1.17e-01 0.171000 4.03e-01
GO:0000987 cis-regulatory region sequence-specific DNA binding 22 1.65e-01 -0.171000 4.63e-01
GO:0051491 positive regulation of filopodium assembly 15 2.52e-01 -0.171000 5.68e-01
GO:0001046 core promoter sequence-specific DNA binding 11 3.28e-01 -0.170000 6.49e-01
GO:0040018 positive regulation of multicellular organism growth 16 2.38e-01 -0.170000 5.49e-01
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 32 9.60e-02 0.170000 3.64e-01
GO:0001938 positive regulation of endothelial cell proliferation 23 1.58e-01 0.170000 4.50e-01
GO:0035267 NuA4 histone acetyltransferase complex 18 2.12e-01 -0.170000 5.18e-01
GO:0045995 regulation of embryonic development 27 1.27e-01 -0.170000 4.15e-01
GO:0048488 synaptic vesicle endocytosis 20 1.90e-01 0.169000 4.93e-01
GO:0050772 positive regulation of axonogenesis 13 2.91e-01 -0.169000 6.14e-01
GO:0006906 vesicle fusion 15 2.57e-01 0.169000 5.73e-01
GO:0000228 nuclear chromosome 13 2.92e-01 -0.169000 6.14e-01
GO:0061024 membrane organization 13 2.93e-01 0.169000 6.15e-01
GO:0120009 intermembrane lipid transfer 16 2.44e-01 0.168000 5.56e-01
GO:0030276 clathrin binding 17 2.30e-01 0.168000 5.40e-01
GO:0004721 phosphoprotein phosphatase activity 21 1.83e-01 -0.168000 4.84e-01
GO:0030100 regulation of endocytosis 12 3.14e-01 0.168000 6.34e-01
GO:0003777 microtubule motor activity 23 1.63e-01 -0.168000 4.61e-01
GO:0045184 establishment of protein localization 17 2.31e-01 0.168000 5.40e-01
GO:0048477 oogenesis 14 2.77e-01 -0.168000 5.99e-01
GO:0032735 positive regulation of interleukin-12 production 12 3.16e-01 0.167000 6.34e-01
GO:0006302 double-strand break repair 45 5.22e-02 -0.167000 2.82e-01
GO:0000976 transcription cis-regulatory region binding 55 3.21e-02 -0.167000 2.24e-01
GO:0005667 transcription regulator complex 92 5.64e-03 -0.167000 8.12e-02
GO:0072659 protein localization to plasma membrane 75 1.25e-02 0.167000 1.31e-01
GO:0006367 transcription initiation at RNA polymerase II promoter 20 1.97e-01 0.167000 4.96e-01
GO:0005788 endoplasmic reticulum lumen 40 6.81e-02 0.167000 3.25e-01
GO:0035615 clathrin adaptor activity 10 3.62e-01 0.167000 6.81e-01
GO:0050839 cell adhesion molecule binding 20 1.98e-01 -0.166000 4.97e-01
GO:0006261 DNA-templated DNA replication 18 2.23e-01 -0.166000 5.30e-01
GO:0051010 microtubule plus-end binding 11 3.40e-01 0.166000 6.64e-01
GO:0051117 ATPase binding 44 5.69e-02 0.166000 2.93e-01
GO:0006914 autophagy 44 5.70e-02 0.166000 2.93e-01
GO:0030317 flagellated sperm motility 29 1.22e-01 0.166000 4.09e-01
GO:0048813 dendrite morphogenesis 21 1.89e-01 0.166000 4.92e-01
GO:0140823 histone H2BS36 kinase activity 31 1.12e-01 -0.165000 3.97e-01
GO:0050681 nuclear androgen receptor binding 16 2.54e-01 -0.165000 5.68e-01
GO:0071260 cellular response to mechanical stimulus 23 1.72e-01 0.164000 4.75e-01
GO:0070098 chemokine-mediated signaling pathway 10 3.68e-01 -0.164000 6.88e-01
GO:0051302 regulation of cell division 11 3.45e-01 -0.164000 6.67e-01
GO:0030175 filopodium 30 1.20e-01 0.164000 4.06e-01
GO:0006325 chromatin organization 66 2.12e-02 -0.164000 1.73e-01
GO:0008408 3’-5’ exonuclease activity 10 3.69e-01 -0.164000 6.88e-01
GO:0005765 lysosomal membrane 137 9.57e-04 0.164000 2.61e-02
GO:0002250 adaptive immune response 20 2.05e-01 0.164000 5.08e-01
GO:0048469 cell maturation 10 3.71e-01 0.163000 6.89e-01
GO:0070971 endoplasmic reticulum exit site 19 2.18e-01 0.163000 5.25e-01
GO:0007507 heart development 80 1.17e-02 -0.163000 1.24e-01
GO:0036342 post-anal tail morphogenesis 11 3.50e-01 -0.163000 6.73e-01
GO:0009953 dorsal/ventral pattern formation 16 2.60e-01 -0.163000 5.77e-01
GO:0071230 cellular response to amino acid stimulus 29 1.30e-01 0.163000 4.19e-01
GO:0042470 melanosome 27 1.45e-01 0.162000 4.35e-01
GO:0006974 DNA damage response 120 2.20e-03 -0.162000 4.54e-02
GO:0030016 myofibril 13 3.12e-01 -0.162000 6.34e-01
GO:0016605 PML body 61 2.91e-02 -0.162000 2.11e-01
GO:0051082 unfolded protein binding 56 3.66e-02 0.162000 2.40e-01
GO:0009968 negative regulation of signal transduction 14 2.95e-01 0.162000 6.18e-01
GO:0048704 embryonic skeletal system morphogenesis 18 2.36e-01 0.161000 5.46e-01
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 13 3.14e-01 -0.161000 6.34e-01
GO:0043679 axon terminus 17 2.50e-01 -0.161000 5.67e-01
GO:0007214 gamma-aminobutyric acid signaling pathway 11 3.55e-01 0.161000 6.78e-01
GO:0032760 positive regulation of tumor necrosis factor production 34 1.05e-01 0.161000 3.84e-01
GO:0006406 mRNA export from nucleus 28 1.42e-01 -0.161000 4.32e-01
GO:0046835 carbohydrate phosphorylation 20 2.15e-01 -0.160000 5.23e-01
GO:0008277 regulation of G protein-coupled receptor signaling pathway 16 2.68e-01 0.160000 5.86e-01
GO:0097602 cullin family protein binding 16 2.68e-01 0.160000 5.86e-01
GO:0033344 cholesterol efflux 11 3.59e-01 0.160000 6.79e-01
GO:0005005 transmembrane-ephrin receptor activity 14 3.02e-01 -0.159000 6.23e-01
GO:0003727 single-stranded RNA binding 21 2.06e-01 -0.159000 5.08e-01
GO:0006270 DNA replication initiation 19 2.29e-01 -0.159000 5.39e-01
GO:0043536 positive regulation of blood vessel endothelial cell migration 18 2.42e-01 0.159000 5.55e-01
GO:0070371 ERK1 and ERK2 cascade 20 2.18e-01 0.159000 5.25e-01
GO:0000281 mitotic cytokinesis 34 1.09e-01 0.159000 3.93e-01
GO:0048144 fibroblast proliferation 22 1.97e-01 0.159000 4.96e-01
GO:0007249 canonical NF-kappaB signal transduction 18 2.43e-01 -0.159000 5.55e-01
GO:0031966 mitochondrial membrane 38 9.00e-02 0.159000 3.58e-01
GO:0034220 monoatomic ion transmembrane transport 20 2.19e-01 0.159000 5.25e-01
GO:0046716 muscle cell cellular homeostasis 15 2.87e-01 -0.159000 6.12e-01
GO:0035403 histone H3T6 kinase activity 32 1.21e-01 -0.159000 4.06e-01
GO:0045332 phospholipid translocation 15 2.88e-01 0.158000 6.12e-01
GO:0060079 excitatory postsynaptic potential 15 2.89e-01 0.158000 6.12e-01
GO:0016192 vesicle-mediated transport 101 6.06e-03 0.158000 8.52e-02
GO:0045668 negative regulation of osteoblast differentiation 27 1.55e-01 0.158000 4.47e-01
GO:0035904 aorta development 15 2.90e-01 -0.158000 6.14e-01
GO:0006352 DNA-templated transcription initiation 11 3.66e-01 -0.157000 6.86e-01
GO:0032420 stereocilium 14 3.08e-01 0.157000 6.30e-01
GO:0019933 cAMP-mediated signaling 13 3.27e-01 0.157000 6.48e-01
GO:0071456 cellular response to hypoxia 34 1.14e-01 0.157000 3.98e-01
GO:0000159 protein phosphatase type 2A complex 12 3.47e-01 0.157000 6.69e-01
GO:0004252 serine-type endopeptidase activity 50 5.55e-02 0.157000 2.92e-01
GO:0031462 Cul2-RING ubiquitin ligase complex 15 2.94e-01 -0.157000 6.16e-01
GO:0043627 response to estrogen 11 3.69e-01 0.157000 6.88e-01
GO:0008289 lipid binding 45 6.94e-02 0.157000 3.26e-01
GO:0042605 peptide antigen binding 10 3.93e-01 0.156000 7.04e-01
GO:0060041 retina development in camera-type eye 21 2.16e-01 -0.156000 5.24e-01
GO:0048384 retinoic acid receptor signaling pathway 11 3.71e-01 -0.156000 6.89e-01
GO:0006446 regulation of translational initiation 17 2.67e-01 0.155000 5.86e-01
GO:1901981 phosphatidylinositol phosphate binding 15 2.98e-01 0.155000 6.20e-01
GO:0005739 mitochondrion 608 9.27e-11 0.155000 2.05e-08
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 12 3.53e-01 -0.155000 6.77e-01
GO:0071363 cellular response to growth factor stimulus 19 2.44e-01 -0.155000 5.56e-01
GO:0046329 negative regulation of JNK cascade 12 3.54e-01 0.155000 6.78e-01
GO:0001756 somitogenesis 25 1.82e-01 -0.154000 4.82e-01
GO:0046856 phosphatidylinositol dephosphorylation 26 1.73e-01 -0.154000 4.76e-01
GO:0010569 regulation of double-strand break repair via homologous recombination 10 3.98e-01 -0.154000 7.09e-01
GO:0035175 histone H3S10 kinase activity 31 1.37e-01 -0.154000 4.27e-01
GO:0072354 histone H3T3 kinase activity 31 1.37e-01 -0.154000 4.27e-01
GO:0032755 positive regulation of interleukin-6 production 32 1.33e-01 0.154000 4.22e-01
GO:0016446 somatic hypermutation of immunoglobulin genes 10 4.01e-01 -0.153000 7.09e-01
GO:0005009 insulin receptor activity 14 3.21e-01 -0.153000 6.41e-01
GO:0006402 mRNA catabolic process 14 3.21e-01 0.153000 6.41e-01
GO:0001786 phosphatidylserine binding 24 1.94e-01 0.153000 4.96e-01
GO:0046718 symbiont entry into host cell 22 2.15e-01 -0.153000 5.23e-01
GO:0000086 G2/M transition of mitotic cell cycle 25 1.87e-01 0.152000 4.89e-01
GO:0086091 regulation of heart rate by cardiac conduction 18 2.65e-01 -0.152000 5.82e-01
GO:0016853 isomerase activity 19 2.53e-01 -0.152000 5.68e-01
GO:0070131 positive regulation of mitochondrial translation 10 4.07e-01 0.152000 7.14e-01
GO:0045766 positive regulation of angiogenesis 53 5.66e-02 0.151000 2.93e-01
GO:0050840 extracellular matrix binding 17 2.80e-01 0.151000 6.02e-01
GO:0045785 positive regulation of cell adhesion 15 3.14e-01 -0.150000 6.34e-01
GO:0015297 antiporter activity 18 2.71e-01 0.150000 5.90e-01
GO:0036211 protein modification process 16 3.00e-01 0.150000 6.21e-01
GO:0001778 plasma membrane repair 16 3.00e-01 0.150000 6.21e-01
GO:0070936 protein K48-linked ubiquitination 68 3.32e-02 0.149000 2.28e-01
GO:0090303 positive regulation of wound healing 11 3.91e-01 0.149000 7.03e-01
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 14 3.34e-01 -0.149000 6.55e-01
GO:0007411 axon guidance 78 2.28e-02 -0.149000 1.81e-01
GO:0002682 regulation of immune system process 11 3.92e-01 -0.149000 7.03e-01
GO:0019905 syntaxin binding 25 1.97e-01 0.149000 4.96e-01
GO:0004197 cysteine-type endopeptidase activity 37 1.17e-01 0.149000 4.03e-01
GO:0000939 inner kinetochore 10 4.15e-01 0.149000 7.22e-01
GO:0070847 core mediator complex 19 2.61e-01 0.149000 5.78e-01
GO:0004674 protein serine/threonine kinase activity 204 2.55e-04 -0.149000 9.42e-03
GO:0008198 ferrous iron binding 12 3.74e-01 -0.148000 6.91e-01
GO:0030282 bone mineralization 23 2.19e-01 0.148000 5.25e-01
GO:0031941 filamentous actin 19 2.64e-01 -0.148000 5.82e-01
GO:0046326 positive regulation of D-glucose import 14 3.38e-01 0.148000 6.60e-01
GO:0045815 transcription initiation-coupled chromatin remodeling 20 2.53e-01 -0.148000 5.68e-01
GO:0006695 cholesterol biosynthetic process 16 3.07e-01 0.148000 6.28e-01
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 15 3.23e-01 0.148000 6.42e-01
GO:0000165 MAPK cascade 46 8.36e-02 -0.148000 3.47e-01
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 15 3.23e-01 -0.148000 6.42e-01
GO:0030534 adult behavior 10 4.20e-01 0.147000 7.27e-01
GO:0000785 chromatin 242 8.35e-05 -0.147000 3.70e-03
GO:0005682 U5 snRNP 10 4.20e-01 0.147000 7.27e-01
GO:0051259 protein complex oligomerization 14 3.41e-01 0.147000 6.64e-01
GO:0048511 rhythmic process 25 2.04e-01 -0.147000 5.06e-01
GO:0099560 synaptic membrane adhesion 15 3.27e-01 -0.146000 6.48e-01
GO:0030838 positive regulation of actin filament polymerization 27 1.91e-01 0.145000 4.94e-01
GO:0007064 mitotic sister chromatid cohesion 10 4.26e-01 0.145000 7.33e-01
GO:0030054 cell junction 52 7.00e-02 -0.145000 3.27e-01
GO:0072542 protein phosphatase activator activity 10 4.27e-01 0.145000 7.33e-01
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 12 3.84e-01 -0.145000 6.97e-01
GO:0001894 tissue homeostasis 13 3.65e-01 -0.145000 6.86e-01
GO:0008143 poly(A) binding 13 3.65e-01 -0.145000 6.86e-01
GO:2000773 negative regulation of cellular senescence 12 3.85e-01 0.145000 6.97e-01
GO:0005769 early endosome 141 3.12e-03 0.144000 5.54e-02
GO:0006783 heme biosynthetic process 10 4.29e-01 0.144000 7.35e-01
GO:0019827 stem cell population maintenance 21 2.52e-01 -0.144000 5.68e-01
GO:0003712 transcription coregulator activity 76 2.99e-02 -0.144000 2.16e-01
GO:0004843 cysteine-type deubiquitinase activity 58 5.78e-02 -0.144000 2.95e-01
GO:0048786 presynaptic active zone 10 4.31e-01 -0.144000 7.35e-01
GO:0017116 single-stranded DNA helicase activity 16 3.20e-01 0.144000 6.41e-01
GO:0000724 double-strand break repair via homologous recombination 71 3.71e-02 -0.143000 2.40e-01
GO:0036064 ciliary basal body 103 1.25e-02 0.143000 1.31e-01
GO:0005615 extracellular space 400 1.14e-06 0.142000 9.49e-05
GO:0035770 ribonucleoprotein granule 13 3.74e-01 -0.142000 6.91e-01
GO:0004676 3-phosphoinositide-dependent protein kinase activity 31 1.70e-01 -0.142000 4.73e-01
GO:0032922 circadian regulation of gene expression 34 1.51e-01 -0.142000 4.46e-01
GO:0048147 negative regulation of fibroblast proliferation 15 3.41e-01 -0.142000 6.64e-01
GO:0036503 ERAD pathway 59 6.06e-02 0.141000 3.06e-01
GO:0004679 AMP-activated protein kinase activity 32 1.67e-01 -0.141000 4.68e-01
GO:0034394 protein localization to cell surface 17 3.15e-01 -0.141000 6.34e-01
GO:0015459 potassium channel regulator activity 16 3.30e-01 -0.141000 6.51e-01
GO:0000176 nuclear exosome (RNase complex) 12 3.99e-01 0.141000 7.09e-01
GO:0032481 positive regulation of type I interferon production 18 3.02e-01 0.141000 6.23e-01
GO:0071466 cellular response to xenobiotic stimulus 25 2.26e-01 -0.140000 5.37e-01
GO:0009411 response to UV 23 2.46e-01 -0.140000 5.59e-01
GO:0055037 recycling endosome 56 7.05e-02 0.140000 3.27e-01
GO:0032722 positive regulation of chemokine production 11 4.22e-01 0.140000 7.30e-01
GO:0030424 axon 119 8.72e-03 -0.139000 1.08e-01
GO:0050885 neuromuscular process controlling balance 24 2.38e-01 -0.139000 5.49e-01
GO:0001764 neuron migration 41 1.24e-01 -0.139000 4.11e-01
GO:0010811 positive regulation of cell-substrate adhesion 13 3.88e-01 0.138000 7.00e-01
GO:1902476 chloride transmembrane transport 39 1.35e-01 0.138000 4.24e-01
GO:0045787 positive regulation of cell cycle 13 3.88e-01 0.138000 7.01e-01
GO:0005801 cis-Golgi network 28 2.06e-01 0.138000 5.08e-01
GO:0051496 positive regulation of stress fiber assembly 31 1.84e-01 -0.138000 4.87e-01
GO:0003677 DNA binding 335 1.56e-05 -0.138000 9.23e-04
GO:0045879 negative regulation of smoothened signaling pathway 15 3.56e-01 0.138000 6.78e-01
GO:0090307 mitotic spindle assembly 30 1.93e-01 -0.137000 4.96e-01
GO:0044183 protein folding chaperone 21 2.76e-01 0.137000 5.99e-01
GO:0070979 protein K11-linked ubiquitination 22 2.65e-01 -0.137000 5.82e-01
GO:0005112 Notch binding 13 3.92e-01 0.137000 7.03e-01
GO:0005010 insulin-like growth factor receptor activity 13 3.92e-01 -0.137000 7.03e-01
GO:0045746 negative regulation of Notch signaling pathway 15 3.58e-01 0.137000 6.79e-01
GO:0042632 cholesterol homeostasis 38 1.44e-01 0.137000 4.34e-01
GO:0004711 ribosomal protein S6 kinase activity 32 1.80e-01 -0.137000 4.80e-01
GO:0030017 sarcomere 12 4.11e-01 0.137000 7.20e-01
GO:0001221 transcription coregulator binding 17 3.28e-01 -0.137000 6.49e-01
GO:0120162 positive regulation of cold-induced thermogenesis 30 1.95e-01 0.137000 4.96e-01
GO:0000776 kinetochore 90 2.52e-02 0.137000 1.94e-01
GO:0001570 vasculogenesis 27 2.19e-01 -0.137000 5.25e-01
GO:0010592 positive regulation of lamellipodium assembly 10 4.56e-01 0.136000 7.63e-01
GO:0001223 transcription coactivator binding 23 2.58e-01 -0.136000 5.74e-01
GO:0006805 xenobiotic metabolic process 17 3.31e-01 0.136000 6.51e-01
GO:0007076 mitotic chromosome condensation 10 4.56e-01 0.136000 7.63e-01
GO:0006355 regulation of DNA-templated transcription 158 3.33e-03 -0.136000 5.79e-02
GO:0003774 cytoskeletal motor activity 13 3.98e-01 -0.136000 7.09e-01
GO:0045494 photoreceptor cell maintenance 24 2.51e-01 0.135000 5.68e-01
GO:0007224 smoothened signaling pathway 49 1.02e-01 0.135000 3.78e-01
GO:0001558 regulation of cell growth 24 2.54e-01 -0.135000 5.68e-01
GO:0031410 cytoplasmic vesicle 106 1.69e-02 0.134000 1.54e-01
GO:0014704 intercalated disc 13 4.02e-01 0.134000 7.09e-01
GO:0035064 methylated histone binding 42 1.32e-01 -0.134000 4.22e-01
GO:0070300 phosphatidic acid binding 13 4.04e-01 0.134000 7.10e-01
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 10 4.64e-01 0.134000 7.66e-01
GO:0035924 cellular response to vascular endothelial growth factor stimulus 16 3.56e-01 0.133000 6.78e-01
GO:0035861 site of double-strand break 58 8.06e-02 -0.133000 3.42e-01
GO:0097718 disordered domain specific binding 15 3.74e-01 -0.133000 6.91e-01
GO:0051560 mitochondrial calcium ion homeostasis 13 4.09e-01 0.132000 7.17e-01
GO:0008233 peptidase activity 10 4.70e-01 0.132000 7.71e-01
GO:0005021 vascular endothelial growth factor receptor activity 15 3.76e-01 -0.132000 6.92e-01
GO:0001965 G-protein alpha-subunit binding 10 4.70e-01 0.132000 7.71e-01
GO:0016301 kinase activity 14 3.94e-01 0.132000 7.05e-01
GO:0016579 protein deubiquitination 28 2.28e-01 -0.132000 5.39e-01
GO:0043029 T cell homeostasis 12 4.31e-01 -0.131000 7.35e-01
GO:0005008 hepatocyte growth factor receptor activity 13 4.13e-01 -0.131000 7.21e-01
GO:0005085 guanyl-nucleotide exchange factor activity 143 6.86e-03 -0.131000 9.27e-02
GO:0010508 positive regulation of autophagy 39 1.57e-01 0.131000 4.47e-01
GO:1903078 positive regulation of protein localization to plasma membrane 21 2.99e-01 0.131000 6.20e-01
GO:0008033 tRNA processing 15 3.80e-01 0.131000 6.94e-01
GO:0048854 brain morphogenesis 14 3.96e-01 0.131000 7.08e-01
GO:0009986 cell surface 182 2.36e-03 0.131000 4.70e-02
GO:0016887 ATP hydrolysis activity 215 9.86e-04 -0.131000 2.65e-02
GO:0006364 rRNA processing 65 6.91e-02 -0.130000 3.25e-01
GO:0034244 negative regulation of transcription elongation by RNA polymerase II 13 4.16e-01 0.130000 7.24e-01
GO:0061462 protein localization to lysosome 10 4.77e-01 0.130000 7.77e-01
GO:0043124 negative regulation of canonical NF-kappaB signal transduction 36 1.79e-01 0.130000 4.80e-01
GO:0006366 transcription by RNA polymerase II 74 5.43e-02 -0.129000 2.88e-01
GO:0006816 calcium ion transport 19 3.31e-01 0.129000 6.51e-01
GO:0001782 B cell homeostasis 11 4.61e-01 -0.128000 7.66e-01
GO:0007059 chromosome segregation 41 1.56e-01 0.128000 4.47e-01
GO:0001650 fibrillar center 102 2.57e-02 -0.128000 1.96e-01
GO:0030672 synaptic vesicle membrane 44 1.42e-01 0.128000 4.33e-01
GO:0140801 histone H2AXY142 kinase activity 23 2.92e-01 -0.127000 6.14e-01
GO:0005262 calcium channel activity 21 3.15e-01 0.127000 6.34e-01
GO:0048787 presynaptic active zone membrane 10 4.88e-01 -0.127000 7.82e-01
GO:0046847 filopodium assembly 11 4.68e-01 0.126000 7.69e-01
GO:0008021 synaptic vesicle 47 1.35e-01 0.126000 4.22e-01
GO:0033209 tumor necrosis factor-mediated signaling pathway 15 3.98e-01 -0.126000 7.09e-01
GO:0045648 positive regulation of erythrocyte differentiation 18 3.56e-01 -0.126000 6.78e-01
GO:0030522 intracellular receptor signaling pathway 18 3.56e-01 -0.126000 6.78e-01
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 11 4.71e-01 0.125000 7.71e-01
GO:0000381 regulation of alternative mRNA splicing, via spliceosome 31 2.27e-01 -0.125000 5.39e-01
GO:0032720 negative regulation of tumor necrosis factor production 18 3.58e-01 -0.125000 6.79e-01
GO:0016757 glycosyltransferase activity 15 4.02e-01 -0.125000 7.09e-01
GO:0046580 negative regulation of Ras protein signal transduction 13 4.35e-01 -0.125000 7.39e-01
GO:0042273 ribosomal large subunit biogenesis 22 3.11e-01 0.125000 6.32e-01
GO:0006915 apoptotic process 135 1.24e-02 0.125000 1.30e-01
GO:0012505 endomembrane system 97 3.38e-02 0.125000 2.30e-01
GO:0045773 positive regulation of axon extension 10 4.94e-01 -0.125000 7.84e-01
GO:0003729 mRNA binding 145 9.64e-03 -0.125000 1.11e-01
GO:0046982 protein heterodimerization activity 132 1.36e-02 0.125000 1.36e-01
GO:0004842 ubiquitin-protein transferase activity 66 8.03e-02 -0.125000 3.42e-01
GO:0000145 exocyst 11 4.74e-01 0.125000 7.75e-01
GO:0070373 negative regulation of ERK1 and ERK2 cascade 30 2.38e-01 -0.125000 5.49e-01
GO:0030215 semaphorin receptor binding 11 4.75e-01 -0.125000 7.75e-01
GO:0042826 histone deacetylase binding 66 8.06e-02 -0.124000 3.42e-01
GO:0000049 tRNA binding 52 1.21e-01 0.124000 4.06e-01
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 10 4.96e-01 0.124000 7.84e-01
GO:0030687 preribosome, large subunit precursor 12 4.58e-01 -0.124000 7.65e-01
GO:0007166 cell surface receptor signaling pathway 41 1.71e-01 0.124000 4.73e-01
GO:0010507 negative regulation of autophagy 22 3.16e-01 -0.124000 6.34e-01
GO:0008076 voltage-gated potassium channel complex 23 3.05e-01 -0.124000 6.27e-01
GO:0050767 regulation of neurogenesis 14 4.26e-01 -0.123000 7.33e-01
GO:0042127 regulation of cell population proliferation 45 1.56e-01 0.122000 4.47e-01
GO:0035098 ESC/E(Z) complex 12 4.64e-01 -0.122000 7.66e-01
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 12 4.64e-01 -0.122000 7.66e-01
GO:0005929 cilium 79 6.15e-02 0.122000 3.08e-01
GO:0030674 protein-macromolecule adaptor activity 73 7.25e-02 0.122000 3.32e-01
GO:0030220 platelet formation 11 4.86e-01 -0.121000 7.79e-01
GO:0060348 bone development 26 2.85e-01 0.121000 6.09e-01
GO:0005721 pericentric heterochromatin 18 3.74e-01 -0.121000 6.91e-01
GO:0003676 nucleic acid binding 106 3.16e-02 -0.121000 2.23e-01
GO:0008380 RNA splicing 47 1.53e-01 -0.121000 4.47e-01
GO:0000287 magnesium ion binding 152 1.05e-02 0.121000 1.16e-01
GO:0010494 cytoplasmic stress granule 58 1.13e-01 -0.120000 3.97e-01
GO:0061157 mRNA destabilization 12 4.71e-01 -0.120000 7.71e-01
GO:0008333 endosome to lysosome transport 32 2.39e-01 0.120000 5.51e-01
GO:0071479 cellular response to ionizing radiation 22 3.30e-01 -0.120000 6.51e-01
GO:0006513 protein monoubiquitination 27 2.81e-01 0.120000 6.03e-01
GO:0031514 motile cilium 39 1.96e-01 0.120000 4.96e-01
GO:0006281 DNA repair 95 4.44e-02 -0.119000 2.60e-01
GO:0031418 L-ascorbic acid binding 14 4.41e-01 0.119000 7.45e-01
GO:0042981 regulation of apoptotic process 54 1.31e-01 -0.119000 4.20e-01
GO:0005791 rough endoplasmic reticulum 12 4.76e-01 -0.119000 7.77e-01
GO:0071364 cellular response to epidermal growth factor stimulus 19 3.71e-01 0.119000 6.89e-01
GO:0071356 cellular response to tumor necrosis factor 38 2.06e-01 0.119000 5.08e-01
GO:0005794 Golgi apparatus 469 1.25e-05 0.118000 7.90e-04
GO:0005685 U1 snRNP 12 4.78e-01 0.118000 7.77e-01
GO:0005019 platelet-derived growth factor beta-receptor activity 13 4.62e-01 -0.118000 7.66e-01
GO:0051018 protein kinase A binding 12 4.79e-01 -0.118000 7.77e-01
GO:0070382 exocytic vesicle 10 5.19e-01 0.118000 7.95e-01
GO:0001671 ATPase activator activity 18 3.87e-01 0.118000 6.99e-01
GO:0015629 actin cytoskeleton 112 3.21e-02 -0.117000 2.24e-01
GO:0009898 cytoplasmic side of plasma membrane 49 1.56e-01 0.117000 4.47e-01
GO:0071233 cellular response to L-leucine 10 5.21e-01 -0.117000 7.96e-01
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 76 7.85e-02 0.117000 3.41e-01
GO:0031593 polyubiquitin modification-dependent protein binding 19 3.79e-01 0.117000 6.94e-01
GO:0034644 cellular response to UV 33 2.47e-01 -0.116000 5.62e-01
GO:0030330 DNA damage response, signal transduction by p53 class mediator 12 4.85e-01 0.116000 7.79e-01
GO:0045740 positive regulation of DNA replication 11 5.04e-01 -0.116000 7.86e-01
GO:0071539 protein localization to centrosome 20 3.68e-01 -0.116000 6.88e-01
GO:0048026 positive regulation of mRNA splicing, via spliceosome 12 4.86e-01 -0.116000 7.79e-01
GO:0042307 positive regulation of protein import into nucleus 25 3.16e-01 -0.116000 6.34e-01
GO:1990023 mitotic spindle midzone 10 5.27e-01 -0.116000 8.00e-01
GO:0032880 regulation of protein localization 42 1.96e-01 0.115000 4.96e-01
GO:0035035 histone acetyltransferase binding 12 4.90e-01 -0.115000 7.82e-01
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 14 4.56e-01 0.115000 7.63e-01
GO:0003785 actin monomer binding 14 4.56e-01 0.115000 7.63e-01
GO:0051059 NF-kappaB binding 22 3.52e-01 0.115000 6.75e-01
GO:2000300 regulation of synaptic vesicle exocytosis 18 4.00e-01 0.115000 7.09e-01
GO:0016485 protein processing 40 2.10e-01 0.115000 5.16e-01
GO:0051219 phosphoprotein binding 20 3.75e-01 0.115000 6.91e-01
GO:0051649 establishment of localization in cell 40 2.11e-01 0.114000 5.18e-01
GO:0007029 endoplasmic reticulum organization 16 4.30e-01 0.114000 7.35e-01
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex 11 5.13e-01 0.114000 7.91e-01
GO:2000811 negative regulation of anoikis 10 5.33e-01 0.114000 8.02e-01
GO:0006457 protein folding 81 7.68e-02 0.114000 3.41e-01
GO:0031297 replication fork processing 26 3.16e-01 -0.114000 6.34e-01
GO:0019955 cytokine binding 13 4.78e-01 0.114000 7.77e-01
GO:0006935 chemotaxis 14 4.62e-01 0.113000 7.66e-01
GO:0003725 double-stranded RNA binding 44 1.93e-01 -0.113000 4.96e-01
GO:0001784 phosphotyrosine residue binding 27 3.09e-01 -0.113000 6.30e-01
GO:0032211 negative regulation of telomere maintenance via telomerase 10 5.36e-01 -0.113000 8.03e-01
GO:0048487 beta-tubulin binding 22 3.59e-01 0.113000 6.79e-01
GO:0098794 postsynapse 66 1.14e-01 0.113000 3.98e-01
GO:0009925 basal plasma membrane 12 4.99e-01 0.113000 7.84e-01
GO:0050769 positive regulation of neurogenesis 12 5.00e-01 -0.113000 7.84e-01
GO:0007032 endosome organization 28 3.03e-01 -0.113000 6.24e-01
GO:0035401 histone H3Y41 kinase activity 22 3.62e-01 -0.112000 6.81e-01
GO:0005768 endosome 113 3.95e-02 0.112000 2.46e-01
GO:0030332 cyclin binding 20 3.85e-01 0.112000 6.97e-01
GO:0007288 sperm axoneme assembly 17 4.24e-01 -0.112000 7.31e-01
GO:0005179 hormone activity 12 5.02e-01 -0.112000 7.86e-01
GO:0050680 negative regulation of epithelial cell proliferation 24 3.45e-01 0.111000 6.67e-01
GO:0031594 neuromuscular junction 34 2.61e-01 -0.111000 5.78e-01
GO:0035264 multicellular organism growth 67 1.16e-01 -0.111000 4.00e-01
GO:0007274 neuromuscular synaptic transmission 12 5.05e-01 -0.111000 7.87e-01
GO:0016529 sarcoplasmic reticulum 13 4.89e-01 -0.111000 7.82e-01
GO:0032570 response to progesterone 13 4.89e-01 -0.111000 7.82e-01
GO:0001676 long-chain fatty acid metabolic process 11 5.25e-01 0.111000 7.99e-01
GO:0001666 response to hypoxia 51 1.72e-01 -0.111000 4.75e-01
GO:0046034 ATP metabolic process 12 5.08e-01 -0.110000 7.88e-01
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 30 2.97e-01 0.110000 6.20e-01
GO:0008092 cytoskeletal protein binding 15 4.62e-01 -0.110000 7.66e-01
GO:0008283 cell population proliferation 67 1.21e-01 -0.110000 4.06e-01
GO:0009636 response to toxic substance 15 4.63e-01 0.109000 7.66e-01
GO:0006622 protein targeting to lysosome 15 4.64e-01 0.109000 7.66e-01
GO:0019904 protein domain specific binding 104 5.48e-02 0.109000 2.90e-01
GO:0008201 heparin binding 57 1.55e-01 0.109000 4.47e-01
GO:0005158 insulin receptor binding 13 4.96e-01 -0.109000 7.84e-01
GO:0030159 signaling receptor complex adaptor activity 13 4.97e-01 0.109000 7.84e-01
GO:0006303 double-strand break repair via nonhomologous end joining 20 4.02e-01 -0.108000 7.09e-01
GO:0004722 protein serine/threonine phosphatase activity 33 2.82e-01 0.108000 6.04e-01
GO:0016020 membrane 947 2.51e-08 0.108000 2.78e-06
GO:0034446 substrate adhesion-dependent cell spreading 35 2.72e-01 -0.107000 5.91e-01
GO:0007030 Golgi organization 63 1.41e-01 0.107000 4.32e-01
GO:0009966 regulation of signal transduction 38 2.54e-01 -0.107000 5.68e-01
GO:0042254 ribosome biogenesis 16 4.59e-01 -0.107000 7.66e-01
GO:0010506 regulation of autophagy 26 3.46e-01 -0.107000 6.68e-01
GO:0036464 cytoplasmic ribonucleoprotein granule 36 2.69e-01 0.107000 5.87e-01
GO:0008237 metallopeptidase activity 12 5.23e-01 0.106000 7.97e-01
GO:1901673 regulation of mitotic spindle assembly 16 4.61e-01 0.106000 7.66e-01
GO:0038066 p38MAPK cascade 11 5.42e-01 -0.106000 8.08e-01
GO:0044291 cell-cell contact zone 14 4.93e-01 -0.106000 7.84e-01
GO:0035613 RNA stem-loop binding 11 5.44e-01 -0.106000 8.09e-01
GO:0007628 adult walking behavior 13 5.09e-01 -0.106000 7.88e-01
GO:0048839 inner ear development 13 5.10e-01 0.106000 7.88e-01
GO:0003180 aortic valve morphogenesis 12 5.27e-01 -0.105000 8.00e-01
GO:0070085 glycosylation 14 4.96e-01 0.105000 7.84e-01
GO:0035855 megakaryocyte development 10 5.69e-01 -0.104000 8.27e-01
GO:0006357 regulation of transcription by RNA polymerase II 548 3.52e-05 -0.104000 1.83e-03
GO:0016251 RNA polymerase II general transcription initiation factor activity 22 3.99e-01 0.104000 7.09e-01
GO:0031901 early endosome membrane 75 1.20e-01 0.104000 4.06e-01
GO:0048278 vesicle docking 13 5.17e-01 0.104000 7.94e-01
GO:0010008 endosome membrane 86 9.67e-02 0.104000 3.64e-01
GO:0071944 cell periphery 12 5.35e-01 0.104000 8.02e-01
GO:0009749 response to glucose 14 5.03e-01 -0.103000 7.86e-01
GO:0099175 regulation of postsynapse organization 20 4.24e-01 0.103000 7.31e-01
GO:0006897 endocytosis 92 8.73e-02 0.103000 3.55e-01
GO:0030295 protein kinase activator activity 21 4.13e-01 -0.103000 7.21e-01
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 156 2.69e-02 0.103000 2.01e-01
GO:2000045 regulation of G1/S transition of mitotic cell cycle 19 4.38e-01 0.103000 7.41e-01
GO:0045732 positive regulation of protein catabolic process 46 2.29e-01 0.103000 5.39e-01
GO:0009954 proximal/distal pattern formation 14 5.07e-01 -0.102000 7.88e-01
GO:0022857 transmembrane transporter activity 40 2.63e-01 -0.102000 5.80e-01
GO:0005666 RNA polymerase III complex 12 5.40e-01 0.102000 8.06e-01
GO:0051726 regulation of cell cycle 104 7.24e-02 -0.102000 3.32e-01
GO:0051017 actin filament bundle assembly 13 5.27e-01 0.101000 8.00e-01
GO:0070830 bicellular tight junction assembly 19 4.48e-01 0.101000 7.54e-01
GO:1990904 ribonucleoprotein complex 104 7.66e-02 0.101000 3.41e-01
GO:0051965 positive regulation of synapse assembly 22 4.15e-01 0.100000 7.22e-01
GO:0006351 DNA-templated transcription 36 2.98e-01 -0.100000 6.20e-01
GO:0006887 exocytosis 43 2.56e-01 0.100000 5.70e-01
GO:0005484 SNAP receptor activity 26 3.77e-01 0.100000 6.92e-01
GO:0033017 sarcoplasmic reticulum membrane 10 5.84e-01 -0.100000 8.37e-01
GO:0050728 negative regulation of inflammatory response 49 2.26e-01 0.099900 5.37e-01
GO:0030183 B cell differentiation 27 3.69e-01 0.099900 6.88e-01
GO:0016604 nuclear body 173 2.37e-02 -0.099900 1.86e-01
GO:0016342 catenin complex 13 5.33e-01 0.099900 8.02e-01
GO:0000932 P-body 61 1.78e-01 -0.099900 4.79e-01
GO:0005689 U12-type spliceosomal complex 20 4.40e-01 0.099800 7.44e-01
GO:0008023 transcription elongation factor complex 14 5.19e-01 -0.099700 7.95e-01
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 13 5.34e-01 -0.099600 8.02e-01
GO:0007229 integrin-mediated signaling pathway 44 2.54e-01 -0.099400 5.68e-01
GO:0098586 cellular response to virus 22 4.20e-01 0.099300 7.27e-01
GO:0015026 coreceptor activity 13 5.35e-01 0.099300 8.03e-01
GO:0007040 lysosome organization 33 3.24e-01 -0.099300 6.43e-01
GO:0035591 signaling adaptor activity 40 2.79e-01 0.099000 6.00e-01
GO:0032154 cleavage furrow 28 3.65e-01 0.099000 6.86e-01
GO:0033173 calcineurin-NFAT signaling cascade 10 5.88e-01 -0.098900 8.38e-01
GO:0003341 cilium movement 10 5.88e-01 -0.098900 8.38e-01
GO:0031369 translation initiation factor binding 12 5.53e-01 0.098800 8.17e-01
GO:0016607 nuclear speck 243 8.30e-03 -0.098600 1.06e-01
GO:0000786 nucleosome 16 4.96e-01 -0.098400 7.84e-01
GO:0000460 maturation of 5.8S rRNA 11 5.73e-01 0.098300 8.29e-01
GO:0030515 snoRNA binding 14 5.25e-01 -0.098200 7.99e-01
GO:0007155 cell adhesion 104 8.44e-02 -0.098100 3.49e-01
GO:0005778 peroxisomal membrane 28 3.70e-01 0.098000 6.88e-01
GO:0043531 ADP binding 21 4.37e-01 -0.097900 7.41e-01
GO:0045214 sarcomere organization 12 5.57e-01 0.097800 8.21e-01
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 85 1.19e-01 -0.097800 4.06e-01
GO:0005576 extracellular region 239 9.46e-03 0.097700 1.09e-01
GO:0042813 Wnt receptor activity 13 5.42e-01 0.097600 8.08e-01
GO:0048706 embryonic skeletal system development 16 4.99e-01 0.097600 7.84e-01
GO:0051721 protein phosphatase 2A binding 14 5.28e-01 -0.097400 8.00e-01
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 37 3.06e-01 -0.097300 6.28e-01
GO:0015485 cholesterol binding 28 3.75e-01 0.096900 6.91e-01
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 114 7.45e-02 -0.096800 3.37e-01
GO:0042734 presynaptic membrane 36 3.15e-01 -0.096800 6.34e-01
GO:0006612 protein targeting to membrane 24 4.13e-01 0.096500 7.21e-01
GO:0008360 regulation of cell shape 60 1.96e-01 -0.096500 4.96e-01
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 393 1.13e-03 -0.096100 2.99e-02
GO:0005581 collagen trimer 18 4.82e-01 0.095700 7.79e-01
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 15 5.22e-01 -0.095600 7.96e-01
GO:0006275 regulation of DNA replication 24 4.18e-01 -0.095600 7.25e-01
GO:2000737 negative regulation of stem cell differentiation 12 5.68e-01 -0.095200 8.27e-01
GO:0034614 cellular response to reactive oxygen species 16 5.10e-01 0.095100 7.88e-01
GO:0038202 TORC1 signaling 12 5.68e-01 0.095100 8.27e-01
GO:0071347 cellular response to interleukin-1 17 5.00e-01 0.094600 7.84e-01
GO:0034113 heterotypic cell-cell adhesion 11 5.87e-01 -0.094500 8.38e-01
GO:0008203 cholesterol metabolic process 29 3.80e-01 0.094200 6.94e-01
GO:0006260 DNA replication 34 3.42e-01 -0.094200 6.65e-01
GO:0030155 regulation of cell adhesion 19 4.78e-01 -0.094000 7.77e-01
GO:0004435 phosphatidylinositol phospholipase C activity 12 5.73e-01 0.094000 8.29e-01
GO:0060612 adipose tissue development 23 4.36e-01 0.093800 7.40e-01
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 34 3.45e-01 -0.093600 6.67e-01
GO:0060324 face development 14 5.44e-01 -0.093600 8.09e-01
GO:0043153 entrainment of circadian clock by photoperiod 13 5.60e-01 -0.093400 8.23e-01
GO:0048008 platelet-derived growth factor receptor signaling pathway 17 5.05e-01 -0.093400 7.87e-01
GO:0097191 extrinsic apoptotic signaling pathway 20 4.70e-01 0.093300 7.71e-01
GO:0007338 single fertilization 19 4.84e-01 0.092900 7.79e-01
GO:0006298 mismatch repair 16 5.21e-01 -0.092700 7.96e-01
GO:0030496 midbody 99 1.12e-01 0.092400 3.97e-01
GO:0048705 skeletal system morphogenesis 14 5.50e-01 0.092400 8.13e-01
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 41 3.07e-01 0.092300 6.28e-01
GO:0030425 dendrite 132 6.85e-02 -0.092000 3.25e-01
GO:0002230 positive regulation of defense response to virus by host 11 5.98e-01 -0.091800 8.45e-01
GO:0007259 cell surface receptor signaling pathway via JAK-STAT 22 4.56e-01 0.091800 7.63e-01
GO:0031012 extracellular matrix 92 1.29e-01 -0.091800 4.18e-01
GO:0071300 cellular response to retinoic acid 17 5.13e-01 -0.091600 7.91e-01
GO:0035331 negative regulation of hippo signaling 18 5.04e-01 -0.091000 7.86e-01
GO:0051536 iron-sulfur cluster binding 12 5.85e-01 0.091000 8.37e-01
GO:0070402 NADPH binding 10 6.19e-01 0.090900 8.56e-01
GO:0045893 positive regulation of DNA-templated transcription 224 1.98e-02 -0.090600 1.64e-01
GO:0009267 cellular response to starvation 48 2.78e-01 0.090500 6.00e-01
GO:0006397 mRNA processing 72 1.85e-01 -0.090400 4.87e-01
GO:1904047 S-adenosyl-L-methionine binding 13 5.74e-01 0.090100 8.29e-01
GO:0098982 GABA-ergic synapse 29 4.01e-01 0.090100 7.09e-01
GO:0003688 DNA replication origin binding 12 5.92e-01 -0.089400 8.41e-01
GO:0046983 protein dimerization activity 70 1.97e-01 -0.089200 4.96e-01
GO:0031507 heterochromatin formation 27 4.25e-01 -0.088700 7.32e-01
GO:0031072 heat shock protein binding 26 4.34e-01 -0.088600 7.39e-01
GO:0048513 animal organ development 11 6.11e-01 -0.088600 8.53e-01
GO:0007420 brain development 78 1.77e-01 -0.088500 4.79e-01
GO:0098655 monoatomic cation transmembrane transport 14 5.68e-01 -0.088200 8.27e-01
GO:0007010 cytoskeleton organization 51 2.78e-01 -0.087900 6.00e-01
GO:0036126 sperm flagellum 33 3.83e-01 0.087900 6.97e-01
GO:0031032 actomyosin structure organization 17 5.31e-01 -0.087900 8.01e-01
GO:0001708 cell fate specification 12 5.98e-01 -0.087800 8.45e-01
GO:0005802 trans-Golgi network 100 1.30e-01 0.087800 4.19e-01
GO:0001654 eye development 17 5.32e-01 -0.087600 8.02e-01
GO:0008083 growth factor activity 39 3.44e-01 0.087500 6.67e-01
GO:0005509 calcium ion binding 258 1.64e-02 0.087000 1.53e-01
GO:0070840 dynein complex binding 12 6.03e-01 0.086800 8.49e-01
GO:0008180 COP9 signalosome 21 4.92e-01 0.086700 7.84e-01
GO:0001968 fibronectin binding 10 6.36e-01 -0.086500 8.64e-01
GO:0060271 cilium assembly 127 9.36e-02 0.086300 3.64e-01
GO:0043005 neuron projection 96 1.45e-01 0.086300 4.35e-01
GO:0006954 inflammatory response 84 1.74e-01 0.085900 4.77e-01
GO:0048666 neuron development 26 4.49e-01 -0.085900 7.55e-01
GO:0042130 negative regulation of T cell proliferation 12 6.07e-01 0.085800 8.51e-01
GO:0000122 negative regulation of transcription by RNA polymerase II 396 3.59e-03 -0.085700 5.88e-02
GO:0003689 DNA clamp loader activity 32 4.04e-01 -0.085300 7.10e-01
GO:0007004 telomere maintenance via telomerase 11 6.25e-01 -0.085100 8.57e-01
GO:0005543 phospholipid binding 39 3.58e-01 -0.085100 6.79e-01
GO:0006509 membrane protein ectodomain proteolysis 15 5.69e-01 0.084900 8.27e-01
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 21 5.02e-01 0.084600 7.86e-01
GO:0005506 iron ion binding 64 2.43e-01 0.084500 5.55e-01
GO:0098719 sodium ion import across plasma membrane 10 6.44e-01 -0.084400 8.68e-01
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 347 7.14e-03 -0.084400 9.51e-02
GO:0065003 protein-containing complex assembly 37 3.75e-01 -0.084400 6.91e-01
GO:0032588 trans-Golgi network membrane 26 4.57e-01 0.084400 7.63e-01
GO:0019901 protein kinase binding 236 2.64e-02 0.084100 1.99e-01
GO:0043021 ribonucleoprotein complex binding 23 4.86e-01 0.084000 7.79e-01
GO:0034450 ubiquitin-ubiquitin ligase activity 12 6.16e-01 0.083600 8.56e-01
GO:0035329 hippo signaling 17 5.51e-01 -0.083500 8.14e-01
GO:0043410 positive regulation of MAPK cascade 61 2.60e-01 0.083400 5.77e-01
GO:0050673 epithelial cell proliferation 19 5.30e-01 0.083300 8.00e-01
GO:0071013 catalytic step 2 spliceosome 52 2.99e-01 -0.083200 6.21e-01
GO:0045944 positive regulation of transcription by RNA polymerase II 528 1.15e-03 -0.083200 2.99e-02
GO:0090575 RNA polymerase II transcription regulator complex 53 2.96e-01 -0.083100 6.18e-01
GO:0048870 cell motility 12 6.18e-01 0.083100 8.56e-01
GO:0030946 protein tyrosine phosphatase activity, metal-dependent 15 5.78e-01 -0.083000 8.31e-01
GO:0140793 histone H2AXY142 phosphatase activity 15 5.78e-01 -0.083000 8.31e-01
GO:0048255 mRNA stabilization 16 5.65e-01 -0.083000 8.27e-01
GO:0051894 positive regulation of focal adhesion assembly 15 5.78e-01 0.083000 8.31e-01
GO:0048471 perinuclear region of cytoplasm 288 1.59e-02 0.082900 1.49e-01
GO:0048536 spleen development 23 4.92e-01 -0.082700 7.84e-01
GO:0005912 adherens junction 69 2.35e-01 -0.082700 5.46e-01
GO:0045665 negative regulation of neuron differentiation 24 4.84e-01 -0.082700 7.79e-01
GO:0019899 enzyme binding 111 1.33e-01 0.082600 4.22e-01
GO:0016787 hydrolase activity 108 1.39e-01 -0.082500 4.29e-01
GO:0001702 gastrulation with mouth forming second 10 6.52e-01 0.082300 8.74e-01
GO:0005741 mitochondrial outer membrane 95 1.67e-01 0.082200 4.67e-01
GO:1905168 positive regulation of double-strand break repair via homologous recombination 25 4.79e-01 -0.081700 7.77e-01
GO:0042149 cellular response to glucose starvation 29 4.46e-01 0.081700 7.53e-01
GO:0001568 blood vessel development 20 5.28e-01 -0.081500 8.00e-01
GO:0032465 regulation of cytokinesis 23 4.99e-01 -0.081400 7.84e-01
GO:0061025 membrane fusion 21 5.19e-01 0.081200 7.96e-01
GO:0045171 intercellular bridge 55 2.98e-01 0.081200 6.20e-01
GO:0007015 actin filament organization 72 2.35e-01 0.081000 5.46e-01
GO:0030032 lamellipodium assembly 21 5.23e-01 0.080600 7.97e-01
GO:0001649 osteoblast differentiation 39 3.84e-01 -0.080500 6.97e-01
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 36 4.04e-01 -0.080500 7.10e-01
GO:0008284 positive regulation of cell population proliferation 157 8.32e-02 0.080300 3.47e-01
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity 16 5.79e-01 0.080100 8.33e-01
GO:0008654 phospholipid biosynthetic process 12 6.32e-01 0.079800 8.62e-01
GO:0005868 cytoplasmic dynein complex 14 6.05e-01 0.079800 8.50e-01
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 13 6.19e-01 -0.079600 8.56e-01
GO:0046330 positive regulation of JNK cascade 38 3.96e-01 -0.079500 7.08e-01
GO:0042147 retrograde transport, endosome to Golgi 50 3.31e-01 0.079500 6.51e-01
GO:0007368 determination of left/right symmetry 28 4.68e-01 0.079300 7.69e-01
GO:0006006 glucose metabolic process 26 4.84e-01 0.079200 7.79e-01
GO:0031201 SNARE complex 33 4.31e-01 0.079200 7.35e-01
GO:0048167 regulation of synaptic plasticity 16 5.85e-01 -0.078900 8.37e-01
GO:0006486 protein glycosylation 45 3.61e-01 0.078700 6.81e-01
GO:0070062 extracellular exosome 41 3.84e-01 0.078700 6.97e-01
GO:0120020 cholesterol transfer activity 11 6.52e-01 -0.078600 8.74e-01
GO:0070050 neuron cellular homeostasis 14 6.13e-01 -0.078000 8.55e-01
GO:0030073 insulin secretion 13 6.27e-01 -0.078000 8.57e-01
GO:0098685 Schaffer collateral - CA1 synapse 44 3.74e-01 0.077500 6.91e-01
GO:0060173 limb development 23 5.21e-01 -0.077400 7.96e-01
GO:0051382 kinetochore assembly 11 6.57e-01 0.077300 8.77e-01
GO:0042177 negative regulation of protein catabolic process 24 5.13e-01 0.077100 7.91e-01
GO:1990782 protein tyrosine kinase binding 14 6.18e-01 0.077100 8.56e-01
GO:0045296 cadherin binding 28 4.82e-01 0.076800 7.79e-01
GO:0030177 positive regulation of Wnt signaling pathway 17 5.84e-01 0.076800 8.37e-01
GO:0008285 negative regulation of cell population proliferation 116 1.55e-01 0.076600 4.47e-01
GO:0004714 transmembrane receptor protein tyrosine kinase activity 14 6.20e-01 0.076500 8.56e-01
GO:0072089 stem cell proliferation 22 5.35e-01 0.076500 8.02e-01
GO:0004521 RNA endonuclease activity 20 5.54e-01 0.076400 8.18e-01
GO:1900182 positive regulation of protein localization to nucleus 25 5.10e-01 -0.076100 7.88e-01
GO:0032715 negative regulation of interleukin-6 production 14 6.22e-01 0.076000 8.57e-01
GO:0045087 innate immune response 82 2.35e-01 0.076000 5.46e-01
GO:0032874 positive regulation of stress-activated MAPK cascade 11 6.64e-01 -0.075600 8.81e-01
GO:0016197 endosomal transport 27 4.99e-01 0.075100 7.84e-01
GO:0016042 lipid catabolic process 29 4.85e-01 0.075000 7.79e-01
GO:0019706 protein-cysteine S-palmitoyltransferase activity 17 5.93e-01 0.074900 8.42e-01
GO:0030010 establishment of cell polarity 18 5.83e-01 0.074800 8.37e-01
GO:0045444 fat cell differentiation 44 3.91e-01 0.074800 7.03e-01
GO:0019838 growth factor binding 11 6.68e-01 -0.074600 8.81e-01
GO:0010595 positive regulation of endothelial cell migration 27 5.03e-01 0.074500 7.86e-01
GO:0009887 animal organ morphogenesis 34 4.52e-01 -0.074500 7.60e-01
GO:0071407 cellular response to organic cyclic compound 11 6.69e-01 -0.074500 8.81e-01
GO:0009410 response to xenobiotic stimulus 47 3.79e-01 -0.074300 6.94e-01
GO:0005102 signaling receptor binding 80 2.52e-01 0.074200 5.68e-01
GO:0050714 positive regulation of protein secretion 19 5.76e-01 -0.074100 8.31e-01
GO:0005540 hyaluronic acid binding 13 6.44e-01 0.074100 8.68e-01
GO:0000922 spindle pole 69 2.90e-01 0.073700 6.14e-01
GO:0043010 camera-type eye development 22 5.51e-01 0.073500 8.14e-01
GO:0042026 protein refolding 12 6.61e-01 -0.073200 8.80e-01
GO:0003779 actin binding 142 1.33e-01 -0.073200 4.22e-01
GO:0043542 endothelial cell migration 14 6.37e-01 -0.072900 8.64e-01
GO:0140297 DNA-binding transcription factor binding 72 2.86e-01 -0.072700 6.10e-01
GO:0005930 axoneme 48 3.84e-01 0.072700 6.97e-01
GO:0000175 3’-5’-RNA exonuclease activity 21 5.66e-01 -0.072400 8.27e-01
GO:0001673 male germ cell nucleus 27 5.16e-01 -0.072300 7.93e-01
GO:0008361 regulation of cell size 12 6.65e-01 0.072200 8.81e-01
GO:0050766 positive regulation of phagocytosis 14 6.40e-01 0.072100 8.65e-01
GO:0045499 chemorepellent activity 18 5.97e-01 -0.071900 8.45e-01
GO:0005925 focal adhesion 114 1.85e-01 -0.071900 4.87e-01
GO:0010761 fibroblast migration 10 6.94e-01 -0.071800 8.93e-01
GO:0043022 ribosome binding 46 4.00e-01 0.071800 7.09e-01
GO:0106310 protein serine kinase activity 38 4.45e-01 -0.071700 7.50e-01
GO:0007409 axonogenesis 41 4.27e-01 -0.071700 7.33e-01
GO:0070374 positive regulation of ERK1 and ERK2 cascade 59 3.43e-01 0.071500 6.65e-01
GO:0005884 actin filament 43 4.18e-01 0.071500 7.25e-01
GO:0045666 positive regulation of neuron differentiation 26 5.30e-01 -0.071200 8.00e-01
GO:0071222 cellular response to lipopolysaccharide 46 4.04e-01 0.071200 7.10e-01
GO:0010842 retina layer formation 12 6.70e-01 -0.071100 8.81e-01
GO:0016525 negative regulation of angiogenesis 35 4.68e-01 -0.070900 7.69e-01
GO:0042802 identical protein binding 663 2.03e-03 0.070800 4.27e-02
GO:0032526 response to retinoic acid 15 6.35e-01 -0.070800 8.64e-01
GO:0050679 positive regulation of epithelial cell proliferation 20 5.85e-01 -0.070500 8.37e-01
GO:0034198 cellular response to amino acid starvation 31 5.00e-01 0.070100 7.84e-01
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 12 6.75e-01 0.069900 8.86e-01
GO:0006289 nucleotide-excision repair 22 5.71e-01 0.069800 8.28e-01
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 19 5.99e-01 0.069800 8.45e-01
GO:0007179 transforming growth factor beta receptor signaling pathway 49 3.99e-01 -0.069700 7.09e-01
GO:0005164 tumor necrosis factor receptor binding 13 6.64e-01 0.069600 8.81e-01
GO:0045595 regulation of cell differentiation 13 6.65e-01 0.069500 8.81e-01
GO:0017134 fibroblast growth factor binding 12 6.78e-01 0.069300 8.87e-01
GO:0005669 transcription factor TFIID complex 22 5.74e-01 0.069300 8.29e-01
GO:0031124 mRNA 3’-end processing 13 6.66e-01 -0.069300 8.81e-01
GO:0032024 positive regulation of insulin secretion 21 5.84e-01 0.069100 8.37e-01
GO:0005178 integrin binding 65 3.36e-01 -0.069000 6.59e-01
GO:0001503 ossification 26 5.43e-01 0.069000 8.08e-01
GO:0070301 cellular response to hydrogen peroxide 24 5.59e-01 -0.069000 8.22e-01
GO:0061630 ubiquitin protein ligase activity 177 1.14e-01 -0.069000 3.99e-01
GO:0032040 small-subunit processome 59 3.60e-01 -0.068900 6.80e-01
GO:0000974 Prp19 complex 10 7.06e-01 -0.068800 9.01e-01
GO:0030837 negative regulation of actin filament polymerization 14 6.56e-01 0.068800 8.77e-01
GO:0071168 protein localization to chromatin 17 6.24e-01 0.068700 8.57e-01
GO:0042803 protein homodimerization activity 373 2.37e-02 0.068500 1.86e-01
GO:0019900 kinase binding 48 4.14e-01 -0.068200 7.22e-01
GO:0016779 nucleotidyltransferase activity 11 6.97e-01 0.067800 8.95e-01
GO:0005686 U2 snRNP 16 6.39e-01 0.067700 8.64e-01
GO:0090398 cellular senescence 19 6.10e-01 -0.067700 8.52e-01
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 183 1.16e-01 -0.067500 4.00e-01
GO:0008253 5’-nucleotidase activity 10 7.13e-01 -0.067300 9.04e-01
GO:0060325 face morphogenesis 20 6.03e-01 -0.067200 8.49e-01
GO:0045892 negative regulation of DNA-templated transcription 174 1.27e-01 -0.067200 4.15e-01
GO:0007416 synapse assembly 25 5.63e-01 -0.066900 8.25e-01
GO:0045669 positive regulation of osteoblast differentiation 37 4.82e-01 -0.066900 7.79e-01
GO:0030488 tRNA methylation 20 6.06e-01 -0.066700 8.50e-01
GO:0005871 kinesin complex 22 5.90e-01 -0.066400 8.40e-01
GO:0048146 positive regulation of fibroblast proliferation 19 6.17e-01 -0.066300 8.56e-01
GO:0007254 JNK cascade 25 5.66e-01 -0.066300 8.27e-01
GO:0097190 apoptotic signaling pathway 20 6.08e-01 0.066200 8.52e-01
GO:0005004 GPI-linked ephrin receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0005011 macrophage colony-stimulating factor receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0005018 platelet-derived growth factor alpha-receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0005020 stem cell factor receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0008288 boss receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway 12 6.91e-01 -0.066200 8.93e-01
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway 12 6.91e-01 -0.066200 8.93e-01
GO:0036332 placental growth factor receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0038145 macrophage colony-stimulating factor signaling pathway 12 6.91e-01 -0.066200 8.93e-01
GO:0060175 brain-derived neurotrophic factor receptor activity 12 6.91e-01 -0.066200 8.93e-01
GO:0008543 fibroblast growth factor receptor signaling pathway 36 4.92e-01 0.066100 7.84e-01
GO:0010467 gene expression 80 3.09e-01 0.065900 6.30e-01
GO:0030521 androgen receptor signaling pathway 12 6.94e-01 0.065700 8.93e-01
GO:0048863 stem cell differentiation 22 5.94e-01 0.065600 8.43e-01
GO:0001525 angiogenesis 86 2.95e-01 0.065400 6.17e-01
GO:0001541 ovarian follicle development 19 6.22e-01 0.065300 8.57e-01
GO:0031625 ubiquitin protein ligase binding 172 1.41e-01 0.065300 4.31e-01
GO:0051604 protein maturation 20 6.15e-01 -0.065000 8.56e-01
GO:0030544 Hsp70 protein binding 29 5.48e-01 0.064500 8.13e-01
GO:0035987 endodermal cell differentiation 21 6.09e-01 0.064400 8.52e-01
GO:0019722 calcium-mediated signaling 32 5.29e-01 -0.064400 8.00e-01
GO:0042552 myelination 28 5.56e-01 0.064300 8.19e-01
GO:0043923 positive regulation by host of viral transcription 12 7.00e-01 0.064300 8.95e-01
GO:0033192 calmodulin-dependent protein phosphatase activity 16 6.56e-01 0.064300 8.77e-01
GO:0006909 phagocytosis 22 6.02e-01 0.064300 8.49e-01
GO:0050852 T cell receptor signaling pathway 50 4.32e-01 0.064200 7.36e-01
GO:0007605 sensory perception of sound 55 4.12e-01 0.064000 7.21e-01
GO:0000070 mitotic sister chromatid segregation 18 6.39e-01 0.064000 8.64e-01
GO:0005635 nuclear envelope 76 3.37e-01 0.063700 6.60e-01
GO:0032212 positive regulation of telomere maintenance via telomerase 17 6.50e-01 0.063600 8.72e-01
GO:0042789 mRNA transcription by RNA polymerase II 27 5.67e-01 -0.063600 8.27e-01
GO:0090090 negative regulation of canonical Wnt signaling pathway 70 3.59e-01 -0.063500 6.79e-01
GO:0030866 cortical actin cytoskeleton organization 20 6.24e-01 0.063300 8.57e-01
GO:0035116 embryonic hindlimb morphogenesis 11 7.16e-01 0.063300 9.05e-01
GO:0140359 ABC-type transporter activity 10 7.30e-01 -0.062900 9.12e-01
GO:0007405 neuroblast proliferation 21 6.19e-01 0.062700 8.56e-01
GO:0045121 membrane raft 73 3.55e-01 0.062600 6.78e-01
GO:0007399 nervous system development 88 3.13e-01 -0.062300 6.34e-01
GO:0006310 DNA recombination 23 6.05e-01 0.062300 8.50e-01
GO:0060382 regulation of DNA strand elongation 10 7.33e-01 -0.062300 9.12e-01
GO:2000786 positive regulation of autophagosome assembly 14 6.87e-01 0.062200 8.93e-01
GO:0005886 plasma membrane 1529 7.41e-05 0.061900 3.55e-03
GO:0007623 circadian rhythm 18 6.50e-01 0.061800 8.72e-01
GO:0050660 flavin adenine dinucleotide binding 33 5.40e-01 0.061700 8.06e-01
GO:0019005 SCF ubiquitin ligase complex 43 4.86e-01 0.061400 7.80e-01
GO:0050804 modulation of chemical synaptic transmission 34 5.37e-01 0.061200 8.04e-01
GO:0051020 GTPase binding 15 6.82e-01 -0.061100 8.89e-01
GO:0007165 signal transduction 265 8.83e-02 0.061000 3.57e-01
GO:0034063 stress granule assembly 21 6.29e-01 0.061000 8.59e-01
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 11 7.26e-01 -0.061000 9.11e-01
GO:0060236 regulation of mitotic spindle organization 12 7.16e-01 -0.060600 9.05e-01
GO:0034451 centriolar satellite 72 3.76e-01 0.060500 6.91e-01
GO:0070527 platelet aggregation 16 6.77e-01 0.060200 8.87e-01
GO:0046872 metal ion binding 873 2.82e-03 -0.060200 5.25e-02
GO:0060339 negative regulation of type I interferon-mediated signaling pathway 13 7.07e-01 -0.060200 9.01e-01
GO:0008053 mitochondrial fusion 17 6.70e-01 0.059800 8.81e-01
GO:0061351 neural precursor cell proliferation 14 6.99e-01 -0.059700 8.95e-01
GO:0038062 protein tyrosine kinase collagen receptor activity 13 7.10e-01 -0.059600 9.02e-01
GO:0045747 positive regulation of Notch signaling pathway 23 6.21e-01 0.059500 8.56e-01
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 30 5.75e-01 -0.059200 8.30e-01
GO:0002020 protease binding 44 4.98e-01 0.059000 7.84e-01
GO:0008217 regulation of blood pressure 20 6.48e-01 0.058900 8.72e-01
GO:0071339 MLL1 complex 18 6.66e-01 -0.058800 8.81e-01
GO:0030490 maturation of SSU-rRNA 12 7.25e-01 0.058700 9.11e-01
GO:0071320 cellular response to cAMP 18 6.67e-01 0.058600 8.81e-01
GO:0032731 positive regulation of interleukin-1 beta production 12 7.25e-01 0.058600 9.11e-01
GO:0035082 axoneme assembly 10 7.48e-01 0.058600 9.20e-01
GO:0019903 protein phosphatase binding 49 4.79e-01 -0.058600 7.77e-01
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway 14 7.05e-01 -0.058500 9.00e-01
GO:0014032 neural crest cell development 11 7.38e-01 0.058300 9.12e-01
GO:0006882 intracellular zinc ion homeostasis 13 7.17e-01 -0.058200 9.05e-01
GO:0005385 zinc ion transmembrane transporter activity 15 6.97e-01 0.058200 8.95e-01
GO:0005524 ATP binding 895 3.52e-03 -0.058100 5.88e-02
GO:0035869 ciliary transition zone 22 6.37e-01 0.058100 8.64e-01
GO:0051403 stress-activated MAPK cascade 12 7.28e-01 0.058000 9.11e-01
GO:0005911 cell-cell junction 78 3.80e-01 -0.057600 6.94e-01
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 33 5.68e-01 0.057500 8.27e-01
GO:0005730 nucleolus 442 4.00e-02 -0.057300 2.46e-01
GO:0008266 poly(U) RNA binding 16 6.92e-01 0.057200 8.93e-01
GO:0050890 cognition 18 6.75e-01 0.057100 8.86e-01
GO:0008013 beta-catenin binding 46 5.04e-01 -0.057000 7.86e-01
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 78 3.86e-01 0.056900 6.98e-01
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 35 5.61e-01 -0.056800 8.24e-01
GO:0055088 lipid homeostasis 19 6.69e-01 -0.056700 8.81e-01
GO:0030878 thyroid gland development 14 7.15e-01 -0.056500 9.05e-01
GO:0042277 peptide binding 10 7.58e-01 0.056400 9.22e-01
GO:0030145 manganese ion binding 45 5.15e-01 0.056200 7.92e-01
GO:0030509 BMP signaling pathway 38 5.49e-01 -0.056200 8.13e-01
GO:0050727 regulation of inflammatory response 26 6.21e-01 -0.056100 8.56e-01
GO:0051087 protein-folding chaperone binding 56 4.68e-01 0.056100 7.69e-01
GO:0019902 phosphatase binding 23 6.42e-01 -0.056000 8.66e-01
GO:0008306 associative learning 11 7.48e-01 0.056000 9.19e-01
GO:0034605 cellular response to heat 16 6.98e-01 0.056000 8.95e-01
GO:0016460 myosin II complex 12 7.38e-01 -0.055900 9.12e-01
GO:0003730 mRNA 3’-UTR binding 51 4.94e-01 -0.055400 7.84e-01
GO:0051879 Hsp90 protein binding 26 6.26e-01 0.055200 8.57e-01
GO:0042100 B cell proliferation 13 7.31e-01 0.055100 9.12e-01
GO:0031116 positive regulation of microtubule polymerization 11 7.52e-01 -0.055100 9.20e-01
GO:0014069 postsynaptic density 97 3.51e-01 0.054900 6.74e-01
GO:0005200 structural constituent of cytoskeleton 28 6.15e-01 -0.054900 8.56e-01
GO:0042742 defense response to bacterium 28 6.17e-01 0.054600 8.56e-01
GO:0010608 post-transcriptional regulation of gene expression 11 7.54e-01 -0.054500 9.20e-01
GO:0060337 type I interferon-mediated signaling pathway 10 7.66e-01 -0.054300 9.27e-01
GO:0051028 mRNA transport 27 6.26e-01 -0.054300 8.57e-01
GO:0030139 endocytic vesicle 37 5.69e-01 -0.054200 8.27e-01
GO:0038023 signaling receptor activity 42 5.44e-01 0.054200 8.09e-01
GO:0006869 lipid transport 27 6.27e-01 0.054100 8.57e-01
GO:0097009 energy homeostasis 23 6.57e-01 -0.053500 8.77e-01
GO:0098793 presynapse 63 4.64e-01 0.053400 7.66e-01
GO:0042593 glucose homeostasis 42 5.50e-01 0.053400 8.13e-01
GO:0003723 RNA binding 372 7.92e-02 -0.053200 3.41e-01
GO:0001822 kidney development 52 5.09e-01 -0.053000 7.88e-01
GO:0042995 cell projection 52 5.09e-01 -0.053000 7.88e-01
GO:0005938 cell cortex 75 4.30e-01 0.052700 7.35e-01
GO:0050796 regulation of insulin secretion 12 7.52e-01 -0.052600 9.20e-01
GO:0071949 FAD binding 27 6.38e-01 0.052300 8.64e-01
GO:0035371 microtubule plus-end 12 7.55e-01 -0.052000 9.20e-01
GO:0055013 cardiac muscle cell development 11 7.67e-01 -0.051700 9.27e-01
GO:0035556 intracellular signal transduction 186 2.27e-01 -0.051500 5.37e-01
GO:0070628 proteasome binding 13 7.49e-01 0.051300 9.20e-01
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 12 7.59e-01 0.051100 9.22e-01
GO:0007417 central nervous system development 41 5.72e-01 0.051000 8.29e-01
GO:0072344 rescue of stalled ribosome 26 6.53e-01 0.050900 8.75e-01
GO:0042162 telomeric DNA binding 20 6.94e-01 -0.050900 8.93e-01
GO:0005829 cytosol 2020 2.62e-04 0.050600 9.48e-03
GO:0090734 site of DNA damage 22 6.82e-01 -0.050500 8.89e-01
GO:0006611 protein export from nucleus 22 6.82e-01 -0.050500 8.89e-01
GO:0016567 protein ubiquitination 155 2.80e-01 -0.050400 6.02e-01
GO:0072686 mitotic spindle 70 4.68e-01 0.050200 7.69e-01
GO:0051290 protein heterotetramerization 10 7.84e-01 -0.050200 9.37e-01
GO:0046676 negative regulation of insulin secretion 10 7.85e-01 -0.049700 9.38e-01
GO:0048741 skeletal muscle fiber development 16 7.31e-01 -0.049700 9.12e-01
GO:0016363 nuclear matrix 46 5.61e-01 -0.049600 8.23e-01
GO:0051123 RNA polymerase II preinitiation complex assembly 16 7.32e-01 0.049500 9.12e-01
GO:1904263 positive regulation of TORC1 signaling 35 6.13e-01 0.049400 8.55e-01
GO:0030286 dynein complex 11 7.78e-01 0.049200 9.34e-01
GO:0030178 negative regulation of Wnt signaling pathway 17 7.27e-01 -0.048900 9.11e-01
GO:0051225 spindle assembly 21 7.00e-01 -0.048600 8.95e-01
GO:0006368 transcription elongation by RNA polymerase II 24 6.80e-01 -0.048600 8.88e-01
GO:0007219 Notch signaling pathway 40 5.95e-01 0.048500 8.44e-01
GO:0008045 motor neuron axon guidance 12 7.71e-01 -0.048500 9.30e-01
GO:0005813 centrosome 346 1.24e-01 0.048300 4.11e-01
GO:0016358 dendrite development 19 7.19e-01 0.047800 9.05e-01
GO:1990573 potassium ion import across plasma membrane 18 7.26e-01 0.047700 9.11e-01
GO:0031526 brush border membrane 12 7.76e-01 0.047400 9.33e-01
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 18 7.29e-01 -0.047100 9.12e-01
GO:0042169 SH2 domain binding 20 7.16e-01 0.047000 9.05e-01
GO:0005516 calmodulin binding 67 5.08e-01 0.046800 7.88e-01
GO:0005518 collagen binding 34 6.37e-01 -0.046700 8.64e-01
GO:0032587 ruffle membrane 41 6.05e-01 -0.046700 8.50e-01
GO:0045022 early endosome to late endosome transport 19 7.28e-01 0.046100 9.11e-01
GO:0017025 TBP-class protein binding 18 7.35e-01 -0.046100 9.12e-01
GO:0000166 nucleotide binding 37 6.29e-01 0.045900 8.59e-01
GO:0001658 branching involved in ureteric bud morphogenesis 16 7.51e-01 -0.045800 9.20e-01
GO:0006605 protein targeting 18 7.37e-01 0.045700 9.12e-01
GO:0000400 four-way junction DNA binding 14 7.68e-01 0.045500 9.28e-01
GO:0008344 adult locomotory behavior 22 7.13e-01 0.045300 9.04e-01
GO:0016592 mediator complex 28 6.78e-01 -0.045300 8.87e-01
GO:0004535 poly(A)-specific ribonuclease activity 10 8.04e-01 -0.045200 9.45e-01
GO:0044877 protein-containing complex binding 104 4.28e-01 0.045100 7.33e-01
GO:0031333 negative regulation of protein-containing complex assembly 16 7.55e-01 0.045100 9.20e-01
GO:0051453 regulation of intracellular pH 14 7.70e-01 0.045000 9.29e-01
GO:0045111 intermediate filament cytoskeleton 23 7.09e-01 0.045000 9.02e-01
GO:0031267 small GTPase binding 165 3.21e-01 -0.044900 6.41e-01
GO:0051085 chaperone cofactor-dependent protein refolding 23 7.10e-01 0.044800 9.02e-01
GO:0007018 microtubule-based movement 41 6.20e-01 -0.044800 8.56e-01
GO:0030864 cortical actin cytoskeleton 32 6.61e-01 -0.044800 8.80e-01
GO:0051260 protein homooligomerization 48 5.93e-01 -0.044700 8.42e-01
GO:0003824 catalytic activity 10 8.08e-01 0.044500 9.47e-01
GO:0005096 GTPase activator activity 152 3.45e-01 -0.044500 6.67e-01
GO:0017022 myosin binding 11 7.99e-01 -0.044300 9.43e-01
GO:0006417 regulation of translation 44 6.12e-01 -0.044200 8.54e-01
GO:0033627 cell adhesion mediated by integrin 22 7.22e-01 0.043800 9.09e-01
GO:1905515 non-motile cilium assembly 39 6.36e-01 0.043800 8.64e-01
GO:0071805 potassium ion transmembrane transport 40 6.32e-01 0.043800 8.62e-01
GO:0051056 regulation of small GTPase mediated signal transduction 16 7.62e-01 -0.043700 9.25e-01
GO:0045672 positive regulation of osteoclast differentiation 11 8.02e-01 0.043600 9.45e-01
GO:0016328 lateral plasma membrane 24 7.13e-01 -0.043400 9.04e-01
GO:0050821 protein stabilization 109 4.35e-01 0.043300 7.39e-01
GO:0042102 positive regulation of T cell proliferation 10 8.16e-01 -0.042600 9.48e-01
GO:0019894 kinesin binding 21 7.36e-01 0.042400 9.12e-01
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 27 7.05e-01 0.042200 9.00e-01
GO:0000124 SAGA complex 15 7.78e-01 -0.042100 9.34e-01
GO:0060218 hematopoietic stem cell differentiation 11 8.09e-01 0.042000 9.47e-01
GO:0002244 hematopoietic progenitor cell differentiation 35 6.68e-01 0.041900 8.81e-01
GO:0030507 spectrin binding 12 8.03e-01 0.041600 9.45e-01
GO:0009982 pseudouridine synthase activity 12 8.03e-01 -0.041500 9.45e-01
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization 13 7.96e-01 0.041500 9.42e-01
GO:0033077 T cell differentiation in thymus 17 7.70e-01 0.041000 9.29e-01
GO:0043066 negative regulation of apoptotic process 152 3.84e-01 0.041000 6.97e-01
GO:0006493 protein O-linked glycosylation 30 6.98e-01 -0.040900 8.95e-01
GO:0043588 skin development 23 7.35e-01 -0.040800 9.12e-01
GO:0004622 lysophospholipase activity 10 8.23e-01 -0.040800 9.54e-01
GO:0043014 alpha-tubulin binding 23 7.35e-01 -0.040800 9.12e-01
GO:0035024 negative regulation of Rho protein signal transduction 14 7.92e-01 0.040800 9.42e-01
GO:0006898 receptor-mediated endocytosis 23 7.36e-01 0.040600 9.12e-01
GO:0002053 positive regulation of mesenchymal cell proliferation 11 8.16e-01 0.040500 9.48e-01
GO:0050750 low-density lipoprotein particle receptor binding 12 8.09e-01 -0.040300 9.47e-01
GO:0007286 spermatid development 25 7.27e-01 -0.040300 9.11e-01
GO:0007204 positive regulation of cytosolic calcium ion concentration 19 7.63e-01 -0.040000 9.25e-01
GO:0042626 ATPase-coupled transmembrane transporter activity 16 7.82e-01 0.040000 9.36e-01
GO:0001678 intracellular glucose homeostasis 17 7.76e-01 -0.039900 9.33e-01
GO:0001618 virus receptor activity 10 8.29e-01 -0.039500 9.56e-01
GO:0001843 neural tube closure 48 6.37e-01 -0.039400 8.64e-01
GO:0048538 thymus development 23 7.44e-01 -0.039300 9.17e-01
GO:0052689 carboxylic ester hydrolase activity 12 8.14e-01 0.039100 9.48e-01
GO:0042098 T cell proliferation 16 7.87e-01 0.038900 9.39e-01
GO:0051019 mitogen-activated protein kinase binding 11 8.24e-01 0.038700 9.55e-01
GO:0007264 small GTPase-mediated signal transduction 47 6.47e-01 0.038700 8.70e-01
GO:0007267 cell-cell signaling 13 8.12e-01 0.038200 9.47e-01
GO:0030182 neuron differentiation 56 6.24e-01 -0.037800 8.57e-01
GO:0004864 protein phosphatase inhibitor activity 13 8.13e-01 0.037800 9.48e-01
GO:0005006 epidermal growth factor receptor activity 14 8.08e-01 -0.037500 9.47e-01
GO:0032418 lysosome localization 23 7.57e-01 -0.037300 9.22e-01
GO:0030168 platelet activation 11 8.32e-01 0.037000 9.56e-01
GO:0005654 nucleoplasm 1529 1.87e-02 -0.036700 1.60e-01
GO:0048012 hepatocyte growth factor receptor signaling pathway 17 7.94e-01 -0.036600 9.42e-01
GO:0005903 brush border 18 7.89e-01 0.036400 9.41e-01
GO:0097550 transcription preinitiation complex 12 8.29e-01 0.036000 9.56e-01
GO:0031965 nuclear membrane 120 4.98e-01 -0.035900 7.84e-01
GO:0060070 canonical Wnt signaling pathway 59 6.35e-01 0.035700 8.64e-01
GO:0007613 memory 28 7.45e-01 -0.035500 9.17e-01
GO:0030374 nuclear receptor coactivator activity 30 7.37e-01 -0.035500 9.12e-01
GO:0007275 multicellular organism development 26 7.55e-01 -0.035400 9.20e-01
GO:0002376 immune system process 12 8.32e-01 -0.035400 9.56e-01
GO:0001222 transcription corepressor binding 27 7.50e-01 -0.035400 9.20e-01
GO:0043204 perikaryon 35 7.19e-01 0.035200 9.05e-01
GO:0097546 ciliary base 17 8.02e-01 0.035200 9.45e-01
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 20 7.86e-01 -0.035000 9.38e-01
GO:0007626 locomotory behavior 26 7.58e-01 0.035000 9.22e-01
GO:0043001 Golgi to plasma membrane protein transport 21 7.82e-01 -0.035000 9.36e-01
GO:0003684 damaged DNA binding 34 7.25e-01 -0.034900 9.11e-01
GO:0004693 cyclin-dependent protein serine/threonine kinase activity 10 8.49e-01 0.034800 9.60e-01
GO:0042391 regulation of membrane potential 12 8.35e-01 -0.034800 9.57e-01
GO:0002102 podosome 18 7.99e-01 0.034600 9.43e-01
GO:0097110 scaffold protein binding 27 7.59e-01 -0.034100 9.22e-01
GO:0001726 ruffle 43 6.99e-01 -0.034100 8.95e-01
GO:0050853 B cell receptor signaling pathway 19 7.97e-01 -0.034000 9.43e-01
GO:0002088 lens development in camera-type eye 14 8.26e-01 0.034000 9.56e-01
GO:0097150 neuronal stem cell population maintenance 18 8.04e-01 0.033900 9.45e-01
GO:0044325 transmembrane transporter binding 55 6.64e-01 0.033800 8.81e-01
GO:0008270 zinc ion binding 404 2.51e-01 -0.033500 5.68e-01
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction 21 7.93e-01 0.033200 9.42e-01
GO:0090263 positive regulation of canonical Wnt signaling pathway 61 6.58e-01 -0.032700 8.78e-01
GO:0016601 Rac protein signal transduction 17 8.15e-01 -0.032700 9.48e-01
GO:0004867 serine-type endopeptidase inhibitor activity 21 7.95e-01 0.032700 9.42e-01
GO:0001664 G protein-coupled receptor binding 22 7.91e-01 0.032600 9.42e-01
GO:0031463 Cul3-RING ubiquitin ligase complex 41 7.18e-01 -0.032600 9.05e-01
GO:0060391 positive regulation of SMAD protein signal transduction 13 8.39e-01 0.032500 9.59e-01
GO:0010629 negative regulation of gene expression 102 5.71e-01 0.032500 8.28e-01
GO:0016324 apical plasma membrane 121 5.38e-01 0.032400 8.05e-01
GO:0043197 dendritic spine 45 7.08e-01 0.032300 9.01e-01
GO:0010634 positive regulation of epithelial cell migration 19 8.10e-01 0.031800 9.47e-01
GO:0017148 negative regulation of translation 44 7.16e-01 0.031700 9.05e-01
GO:0007266 Rho protein signal transduction 33 7.54e-01 0.031600 9.20e-01
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 15 8.33e-01 -0.031500 9.56e-01
GO:0062023 collagen-containing extracellular matrix 73 6.45e-01 -0.031200 8.68e-01
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 27 7.82e-01 0.030800 9.36e-01
GO:0046627 negative regulation of insulin receptor signaling pathway 16 8.31e-01 -0.030800 9.56e-01
GO:0031290 retinal ganglion cell axon guidance 11 8.61e-01 -0.030600 9.65e-01
GO:0035249 synaptic transmission, glutamatergic 17 8.28e-01 -0.030500 9.56e-01
GO:0005770 late endosome 75 6.49e-01 0.030400 8.72e-01
GO:0007528 neuromuscular junction development 15 8.39e-01 -0.030300 9.59e-01
GO:0000712 resolution of meiotic recombination intermediates 14 8.45e-01 -0.030200 9.60e-01
GO:0045211 postsynaptic membrane 57 6.94e-01 -0.030100 8.93e-01
GO:0120163 negative regulation of cold-induced thermogenesis 21 8.12e-01 -0.029900 9.47e-01
GO:0042274 ribosomal small subunit biogenesis 44 7.33e-01 -0.029700 9.12e-01
GO:1990830 cellular response to leukemia inhibitory factor 67 6.77e-01 -0.029500 8.87e-01
GO:0034067 protein localization to Golgi apparatus 13 8.55e-01 0.029200 9.64e-01
GO:0015630 microtubule cytoskeleton 72 6.69e-01 0.029200 8.81e-01
GO:0017053 transcription repressor complex 34 7.68e-01 -0.029200 9.28e-01
GO:0009897 external side of plasma membrane 104 6.07e-01 0.029200 8.51e-01
GO:0005881 cytoplasmic microtubule 30 7.82e-01 0.029200 9.36e-01
GO:0051497 negative regulation of stress fiber assembly 18 8.30e-01 0.029200 9.56e-01
GO:0060586 multicellular organismal-level iron ion homeostasis 16 8.40e-01 -0.029100 9.59e-01
GO:0008017 microtubule binding 153 5.35e-01 0.029100 8.02e-01
GO:0004715 non-membrane spanning protein tyrosine kinase activity 21 8.18e-01 -0.029000 9.49e-01
GO:0016055 Wnt signaling pathway 78 6.59e-01 0.029000 8.78e-01
GO:0070588 calcium ion transmembrane transport 44 7.40e-01 0.028900 9.14e-01
GO:0019888 protein phosphatase regulator activity 16 8.42e-01 -0.028900 9.59e-01
GO:0000993 RNA polymerase II complex binding 23 8.11e-01 -0.028800 9.47e-01
GO:0016922 nuclear receptor binding 21 8.21e-01 0.028600 9.52e-01
GO:0006644 phospholipid metabolic process 11 8.70e-01 0.028600 9.69e-01
GO:0048568 embryonic organ development 16 8.43e-01 0.028600 9.59e-01
GO:0032259 methylation 76 6.72e-01 -0.028100 8.83e-01
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 16 8.47e-01 0.027800 9.60e-01
GO:0001889 liver development 30 7.94e-01 0.027500 9.42e-01
GO:1990837 sequence-specific double-stranded DNA binding 47 7.45e-01 0.027500 9.17e-01
GO:0010575 positive regulation of vascular endothelial growth factor production 13 8.64e-01 -0.027500 9.66e-01
GO:1990498 mitotic spindle microtubule 10 8.81e-01 -0.027500 9.72e-01
GO:0008104 protein localization 67 6.99e-01 -0.027300 8.95e-01
GO:0090316 positive regulation of intracellular protein transport 14 8.60e-01 0.027200 9.65e-01
GO:0035725 sodium ion transmembrane transport 46 7.50e-01 0.027200 9.20e-01
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 19 8.38e-01 0.027100 9.59e-01
GO:1990138 neuron projection extension 10 8.82e-01 -0.027100 9.72e-01
GO:0061744 motor behavior 16 8.53e-01 -0.026800 9.62e-01
GO:0005737 cytoplasm 2176 4.59e-02 0.026800 2.62e-01
GO:0030217 T cell differentiation 19 8.40e-01 -0.026700 9.59e-01
GO:0007026 negative regulation of microtubule depolymerization 17 8.49e-01 -0.026600 9.60e-01
GO:0001578 microtubule bundle formation 16 8.54e-01 -0.026600 9.63e-01
GO:0004177 aminopeptidase activity 13 8.69e-01 0.026500 9.69e-01
GO:0140664 ATP-dependent DNA damage sensor activity 14 8.64e-01 -0.026400 9.66e-01
GO:0006508 proteolysis 177 5.49e-01 0.026200 8.13e-01
GO:0051301 cell division 144 5.88e-01 0.026200 8.38e-01
GO:0007339 binding of sperm to zona pellucida 11 8.81e-01 -0.026100 9.72e-01
GO:0007519 skeletal muscle tissue development 16 8.57e-01 0.026000 9.64e-01
GO:0016477 cell migration 135 6.03e-01 0.026000 8.49e-01
GO:0005125 cytokine activity 28 8.15e-01 0.025600 9.48e-01
GO:0016791 phosphatase activity 15 8.66e-01 -0.025200 9.66e-01
GO:0005776 autophagosome 41 7.80e-01 0.025200 9.36e-01
GO:0006284 base-excision repair 17 8.58e-01 -0.025100 9.64e-01
GO:0008168 methyltransferase activity 13 8.75e-01 -0.025100 9.72e-01
GO:0007186 G protein-coupled receptor signaling pathway 92 6.79e-01 0.025000 8.87e-01
GO:0000118 histone deacetylase complex 22 8.40e-01 -0.024900 9.59e-01
GO:0043015 gamma-tubulin binding 21 8.44e-01 -0.024800 9.59e-01
GO:0005109 frizzled binding 18 8.56e-01 0.024700 9.64e-01
GO:0047496 vesicle transport along microtubule 11 8.87e-01 -0.024700 9.73e-01
GO:0007173 epidermal growth factor receptor signaling pathway 38 7.92e-01 -0.024700 9.42e-01
GO:0009611 response to wounding 20 8.49e-01 0.024600 9.60e-01
GO:0007517 muscle organ development 11 8.88e-01 -0.024600 9.73e-01
GO:0005814 centriole 92 6.84e-01 0.024600 8.91e-01
GO:0001817 regulation of cytokine production 26 8.29e-01 -0.024500 9.56e-01
GO:0001837 epithelial to mesenchymal transition 16 8.66e-01 0.024400 9.66e-01
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 43 7.84e-01 0.024100 9.37e-01
GO:0050830 defense response to Gram-positive bacterium 14 8.76e-01 0.024100 9.72e-01
GO:0048015 phosphatidylinositol-mediated signaling 18 8.60e-01 0.024000 9.65e-01
GO:0008047 enzyme activator activity 15 8.72e-01 -0.024000 9.71e-01
GO:0007160 cell-matrix adhesion 40 7.93e-01 -0.024000 9.42e-01
GO:0032993 protein-DNA complex 21 8.49e-01 0.024000 9.60e-01
GO:0050919 negative chemotaxis 21 8.50e-01 -0.023900 9.60e-01
GO:0016235 aggresome 17 8.65e-01 -0.023800 9.66e-01
GO:0030246 carbohydrate binding 40 7.95e-01 -0.023700 9.42e-01
GO:0072657 protein localization to membrane 19 8.59e-01 0.023600 9.65e-01
GO:0001657 ureteric bud development 14 8.79e-01 -0.023400 9.72e-01
GO:0070888 E-box binding 22 8.49e-01 -0.023400 9.60e-01
GO:0006511 ubiquitin-dependent protein catabolic process 117 6.63e-01 -0.023400 8.81e-01
GO:0030593 neutrophil chemotaxis 13 8.85e-01 -0.023300 9.73e-01
GO:0009952 anterior/posterior pattern specification 42 7.98e-01 -0.022800 9.43e-01
GO:0005154 epidermal growth factor receptor binding 19 8.64e-01 0.022700 9.66e-01
GO:0030216 keratinocyte differentiation 27 8.39e-01 0.022700 9.59e-01
GO:0034097 response to cytokine 12 8.92e-01 0.022600 9.74e-01
GO:0006346 DNA methylation-dependent constitutive heterochromatin formation 10 9.02e-01 -0.022600 9.79e-01
GO:0008584 male gonad development 29 8.34e-01 -0.022500 9.56e-01
GO:0051865 protein autoubiquitination 39 8.08e-01 0.022500 9.47e-01
GO:0030198 extracellular matrix organization 78 7.33e-01 0.022400 9.12e-01
GO:0045722 positive regulation of gluconeogenesis 11 8.98e-01 -0.022300 9.77e-01
GO:0098686 hippocampal mossy fiber to CA3 synapse 18 8.70e-01 0.022300 9.69e-01
GO:0050699 WW domain binding 11 9.01e-01 -0.021800 9.78e-01
GO:0032991 protein-containing complex 208 5.90e-01 0.021700 8.40e-01
GO:0005080 protein kinase C binding 16 8.82e-01 0.021500 9.72e-01
GO:0006955 immune response 42 8.11e-01 -0.021300 9.47e-01
GO:0003697 single-stranded DNA binding 67 7.66e-01 0.021100 9.27e-01
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 19 8.74e-01 0.021000 9.72e-01
GO:0098839 postsynaptic density membrane 35 8.30e-01 -0.020900 9.56e-01
GO:0051289 protein homotetramerization 35 8.30e-01 0.020900 9.56e-01
GO:0007020 microtubule nucleation 14 8.93e-01 -0.020800 9.74e-01
GO:0099170 postsynaptic modulation of chemical synaptic transmission 13 8.97e-01 -0.020700 9.77e-01
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 10 9.10e-01 -0.020600 9.82e-01
GO:0055085 transmembrane transport 86 7.42e-01 0.020600 9.15e-01
GO:0045727 positive regulation of translation 36 8.33e-01 0.020300 9.56e-01
GO:0005923 bicellular tight junction 50 8.05e-01 -0.020200 9.45e-01
GO:0016239 positive regulation of macroautophagy 17 8.86e-01 -0.020000 9.73e-01
GO:0006879 intracellular iron ion homeostasis 31 8.48e-01 0.019900 9.60e-01
GO:0007094 mitotic spindle assembly checkpoint signaling 19 8.81e-01 0.019900 9.72e-01
GO:0006268 DNA unwinding involved in DNA replication 14 8.98e-01 -0.019800 9.77e-01
GO:0036158 outer dynein arm assembly 10 9.14e-01 -0.019600 9.82e-01
GO:0000902 cell morphogenesis 53 8.06e-01 0.019500 9.46e-01
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 10 9.15e-01 0.019500 9.82e-01
GO:0043596 nuclear replication fork 10 9.16e-01 -0.019400 9.82e-01
GO:0045862 positive regulation of proteolysis 12 9.08e-01 0.019400 9.82e-01
GO:0140326 ATPase-coupled intramembrane lipid transporter activity 11 9.12e-01 0.019300 9.82e-01
GO:0035091 phosphatidylinositol binding 74 7.75e-01 0.019300 9.33e-01
GO:0060828 regulation of canonical Wnt signaling pathway 18 8.88e-01 -0.019200 9.73e-01
GO:0043235 receptor complex 77 7.76e-01 -0.018800 9.33e-01
GO:0009617 response to bacterium 36 8.45e-01 0.018800 9.60e-01
GO:0007281 germ cell development 14 9.04e-01 0.018700 9.81e-01
GO:0006936 muscle contraction 10 9.19e-01 -0.018600 9.82e-01
GO:0045599 negative regulation of fat cell differentiation 22 8.80e-01 -0.018500 9.72e-01
GO:0045292 mRNA cis splicing, via spliceosome 13 9.08e-01 -0.018500 9.82e-01
GO:0001947 heart looping 23 8.79e-01 -0.018300 9.72e-01
GO:0007268 chemical synaptic transmission 31 8.62e-01 0.018100 9.66e-01
GO:0045821 positive regulation of glycolytic process 10 9.22e-01 0.018000 9.82e-01
GO:0000151 ubiquitin ligase complex 48 8.30e-01 -0.018000 9.56e-01
GO:1990756 ubiquitin-like ligase-substrate adaptor activity 71 7.95e-01 -0.017800 9.42e-01
GO:0051402 neuron apoptotic process 42 8.43e-01 0.017700 9.59e-01
GO:0030308 negative regulation of cell growth 42 8.43e-01 -0.017600 9.59e-01
GO:0043231 intracellular membrane-bounded organelle 115 7.45e-01 0.017600 9.17e-01
GO:0030890 positive regulation of B cell proliferation 21 8.91e-01 0.017300 9.73e-01
GO:0061608 nuclear import signal receptor activity 14 9.12e-01 -0.017100 9.82e-01
GO:0003333 amino acid transmembrane transport 10 9.26e-01 -0.017100 9.84e-01
GO:0051216 cartilage development 22 8.90e-01 0.017000 9.73e-01
GO:0043065 positive regulation of apoptotic process 121 7.52e-01 0.016600 9.20e-01
GO:0001755 neural crest cell migration 25 8.86e-01 -0.016500 9.73e-01
GO:0007098 centrosome cycle 17 9.09e-01 -0.016100 9.82e-01
GO:0061564 axon development 13 9.20e-01 0.016100 9.82e-01
GO:0005245 voltage-gated calcium channel activity 10 9.31e-01 0.015900 9.85e-01
GO:0051015 actin filament binding 119 7.65e-01 0.015900 9.27e-01
GO:0003151 outflow tract morphogenesis 19 9.08e-01 -0.015300 9.82e-01
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 11 9.30e-01 0.015200 9.85e-01
GO:0004879 nuclear receptor activity 38 8.73e-01 0.015000 9.71e-01
GO:0071577 zinc ion transmembrane transport 10 9.35e-01 0.014900 9.86e-01
GO:0016925 protein sumoylation 19 9.12e-01 -0.014700 9.82e-01
GO:0051457 maintenance of protein location in nucleus 10 9.36e-01 0.014600 9.86e-01
GO:0060412 ventricular septum morphogenesis 18 9.15e-01 0.014500 9.82e-01
GO:0098978 glutamatergic synapse 234 7.06e-01 0.014400 9.01e-01
GO:0038084 vascular endothelial growth factor signaling pathway 23 9.06e-01 0.014300 9.82e-01
GO:0070534 protein K63-linked ubiquitination 31 8.91e-01 0.014200 9.73e-01
GO:0030326 embryonic limb morphogenesis 14 9.27e-01 -0.014200 9.84e-01
GO:0007131 reciprocal meiotic recombination 12 9.32e-01 0.014200 9.86e-01
GO:0043525 positive regulation of neuron apoptotic process 18 9.17e-01 -0.014200 9.82e-01
GO:0070536 protein K63-linked deubiquitination 16 9.22e-01 -0.014200 9.82e-01
GO:0005643 nuclear pore 33 8.90e-01 -0.013900 9.73e-01
GO:0006400 tRNA modification 11 9.38e-01 0.013600 9.87e-01
GO:0004725 protein tyrosine phosphatase activity 44 8.77e-01 0.013400 9.72e-01
GO:0010719 negative regulation of epithelial to mesenchymal transition 17 9.24e-01 -0.013300 9.84e-01
GO:0048873 homeostasis of number of cells within a tissue 14 9.33e-01 -0.012900 9.86e-01
GO:0043130 ubiquitin binding 61 8.64e-01 0.012700 9.66e-01
GO:0000398 mRNA splicing, via spliceosome 87 8.42e-01 -0.012400 9.59e-01
GO:0030165 PDZ domain binding 30 9.10e-01 -0.012000 9.82e-01
GO:0042645 mitochondrial nucleoid 37 9.00e-01 0.011900 9.78e-01
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 44 8.92e-01 0.011800 9.74e-01
GO:0000956 nuclear-transcribed mRNA catabolic process 12 9.44e-01 0.011600 9.91e-01
GO:0005657 replication fork 20 9.29e-01 -0.011500 9.85e-01
GO:0045824 negative regulation of innate immune response 16 9.37e-01 -0.011400 9.86e-01
GO:0003690 double-stranded DNA binding 35 9.07e-01 -0.011400 9.82e-01
GO:0004222 metalloendopeptidase activity 52 8.88e-01 0.011300 9.73e-01
GO:0045453 bone resorption 11 9.48e-01 -0.011300 9.92e-01
GO:0070273 phosphatidylinositol-4-phosphate binding 17 9.36e-01 0.011300 9.86e-01
GO:0046513 ceramide biosynthetic process 19 9.33e-01 0.011200 9.86e-01
GO:0045165 cell fate commitment 21 9.29e-01 -0.011200 9.85e-01
GO:0042060 wound healing 28 9.20e-01 0.011000 9.82e-01
GO:0042752 regulation of circadian rhythm 27 9.21e-01 0.011000 9.82e-01
GO:0032007 negative regulation of TOR signaling 19 9.34e-01 -0.010900 9.86e-01
GO:0000226 microtubule cytoskeleton organization 69 8.78e-01 -0.010700 9.72e-01
GO:0001662 behavioral fear response 12 9.49e-01 -0.010600 9.92e-01
GO:0007283 spermatogenesis 100 8.55e-01 0.010600 9.64e-01
GO:0031648 protein destabilization 32 9.18e-01 -0.010600 9.82e-01
GO:0010976 positive regulation of neuron projection development 30 9.22e-01 0.010400 9.82e-01
GO:0005634 nucleus 2131 4.48e-01 -0.010300 7.54e-01
GO:0051539 4 iron, 4 sulfur cluster binding 33 9.19e-01 -0.010300 9.82e-01
GO:0035019 somatic stem cell population maintenance 31 9.22e-01 0.010200 9.82e-01
GO:0000209 protein polyubiquitination 78 8.77e-01 -0.010100 9.72e-01
GO:0000278 mitotic cell cycle 54 8.98e-01 0.010100 9.77e-01
GO:0004672 protein kinase activity 64 8.90e-01 0.009980 9.73e-01
GO:0007346 regulation of mitotic cell cycle 31 9.24e-01 -0.009860 9.84e-01
GO:0045765 regulation of angiogenesis 11 9.56e-01 -0.009550 9.92e-01
GO:0006874 intracellular calcium ion homeostasis 38 9.19e-01 -0.009510 9.82e-01
GO:0043524 negative regulation of neuron apoptotic process 51 9.07e-01 0.009440 9.82e-01
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 23 9.39e-01 0.009250 9.87e-01
GO:0005007 fibroblast growth factor receptor activity 13 9.55e-01 0.009130 9.92e-01
GO:0042472 inner ear morphogenesis 28 9.34e-01 0.008980 9.86e-01
GO:0030027 lamellipodium 91 8.84e-01 -0.008840 9.73e-01
GO:0007369 gastrulation 10 9.63e-01 -0.008440 9.93e-01
GO:0031624 ubiquitin conjugating enzyme binding 17 9.53e-01 -0.008250 9.92e-01
GO:0098656 monoatomic anion transmembrane transport 18 9.53e-01 0.008070 9.92e-01
GO:0030335 positive regulation of cell migration 108 8.86e-01 0.008020 9.73e-01
GO:0030514 negative regulation of BMP signaling pathway 27 9.43e-01 -0.007970 9.90e-01
GO:0051607 defense response to virus 55 9.21e-01 0.007720 9.82e-01
GO:0001669 acrosomal vesicle 26 9.46e-01 -0.007670 9.92e-01
GO:0048013 ephrin receptor signaling pathway 24 9.48e-01 -0.007660 9.92e-01
GO:0008286 insulin receptor signaling pathway 49 9.26e-01 -0.007640 9.84e-01
GO:0060090 molecular adaptor activity 75 9.09e-01 -0.007600 9.82e-01
GO:0038109 Kit signaling pathway 14 9.61e-01 -0.007590 9.93e-01
GO:0048010 vascular endothelial growth factor receptor signaling pathway 13 9.62e-01 0.007540 9.93e-01
GO:0010628 positive regulation of gene expression 146 8.76e-01 0.007520 9.72e-01
GO:0051209 release of sequestered calcium ion into cytosol 19 9.56e-01 0.007340 9.92e-01
GO:0005819 spindle 54 9.26e-01 0.007260 9.84e-01
GO:0030336 negative regulation of cell migration 51 9.29e-01 -0.007240 9.85e-01
GO:0061436 establishment of skin barrier 13 9.64e-01 0.007150 9.93e-01
GO:0032467 positive regulation of cytokinesis 14 9.64e-01 -0.007050 9.93e-01
GO:0007097 nuclear migration 15 9.63e-01 -0.006930 9.93e-01
GO:0006884 cell volume homeostasis 14 9.64e-01 -0.006920 9.93e-01
GO:0030833 regulation of actin filament polymerization 21 9.57e-01 0.006880 9.92e-01
GO:0036297 interstrand cross-link repair 24 9.54e-01 0.006740 9.92e-01
GO:0030334 regulation of cell migration 35 9.48e-01 -0.006400 9.92e-01
GO:0000794 condensed nuclear chromosome 20 9.62e-01 0.006230 9.93e-01
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 25 9.58e-01 -0.006120 9.93e-01
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 28 9.56e-01 0.006000 9.92e-01
GO:0032869 cellular response to insulin stimulus 33 9.55e-01 0.005740 9.92e-01
GO:0005681 spliceosomal complex 43 9.48e-01 0.005710 9.92e-01
GO:0030901 midbrain development 11 9.75e-01 0.005540 9.93e-01
GO:0043113 receptor clustering 12 9.74e-01 -0.005520 9.93e-01
GO:0017018 myosin phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0140791 histone H2AXS140 phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:1990439 MAP kinase serine/threonine phosphatase activity 13 9.73e-01 0.005460 9.93e-01
GO:0005815 microtubule organizing center 37 9.55e-01 0.005310 9.92e-01
GO:0071005 U2-type precatalytic spliceosome 31 9.59e-01 -0.005280 9.93e-01
GO:0005507 copper ion binding 24 9.64e-01 -0.005260 9.93e-01
GO:0006893 Golgi to plasma membrane transport 19 9.68e-01 -0.005260 9.93e-01
GO:0016740 transferase activity 23 9.65e-01 0.005250 9.93e-01
GO:0032012 regulation of ARF protein signal transduction 14 9.73e-01 0.005200 9.93e-01
GO:0070063 RNA polymerase binding 12 9.75e-01 0.005170 9.93e-01
GO:0000082 G1/S transition of mitotic cell cycle 41 9.55e-01 0.005100 9.92e-01
GO:0035176 social behavior 16 9.72e-01 -0.005080 9.93e-01
GO:0010468 regulation of gene expression 58 9.47e-01 0.005040 9.92e-01
GO:0004930 G protein-coupled receptor activity 57 9.50e-01 -0.004780 9.92e-01
GO:0045880 positive regulation of smoothened signaling pathway 22 9.69e-01 0.004730 9.93e-01
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 85 9.40e-01 0.004710 9.88e-01
GO:0060021 roof of mouth development 35 9.62e-01 -0.004700 9.93e-01
GO:0140374 antiviral innate immune response 20 9.72e-01 0.004540 9.93e-01
GO:0004497 monooxygenase activity 11 9.79e-01 -0.004480 9.93e-01
GO:0006730 one-carbon metabolic process 13 9.78e-01 -0.004450 9.93e-01
GO:0002931 response to ischemia 10 9.81e-01 -0.004300 9.94e-01
GO:0030971 receptor tyrosine kinase binding 32 9.67e-01 0.004260 9.93e-01
GO:0042383 sarcolemma 36 9.66e-01 -0.004060 9.93e-01
GO:0010824 regulation of centrosome duplication 15 9.79e-01 -0.003890 9.93e-01
GO:0031252 cell leading edge 19 9.79e-01 -0.003560 9.93e-01
GO:0009566 fertilization 12 9.84e-01 -0.003400 9.95e-01
GO:0001707 mesoderm formation 15 9.82e-01 -0.003370 9.94e-01
GO:0008305 integrin complex 17 9.81e-01 -0.003300 9.94e-01
GO:0030324 lung development 35 9.76e-01 -0.002940 9.93e-01
GO:0010314 phosphatidylinositol-5-phosphate binding 11 9.87e-01 0.002820 9.97e-01
GO:0019216 regulation of lipid metabolic process 10 9.88e-01 -0.002790 9.97e-01
GO:0005856 cytoskeleton 174 9.52e-01 -0.002630 9.92e-01
GO:0030659 cytoplasmic vesicle membrane 43 9.78e-01 0.002390 9.93e-01
GO:0007265 Ras protein signal transduction 37 9.80e-01 -0.002330 9.94e-01
GO:0008327 methyl-CpG binding 16 9.87e-01 0.002300 9.97e-01
GO:0046488 phosphatidylinositol metabolic process 13 9.89e-01 0.002270 9.97e-01
GO:0043025 neuronal cell body 82 9.74e-01 0.002110 9.93e-01
GO:0001937 negative regulation of endothelial cell proliferation 12 9.91e-01 0.001940 9.98e-01
GO:0016323 basolateral plasma membrane 94 9.75e-01 -0.001860 9.93e-01
GO:1990166 protein localization to site of double-strand break 10 9.93e-01 -0.001550 9.99e-01
GO:0034504 protein localization to nucleus 20 9.92e-01 0.001290 9.98e-01
GO:0099171 presynaptic modulation of chemical synaptic transmission 11 9.95e-01 0.001050 9.99e-01
GO:0030154 cell differentiation 141 9.84e-01 0.000958 9.95e-01
GO:0005515 protein binding 90 9.89e-01 0.000863 9.97e-01
GO:0001569 branching involved in blood vessel morphogenesis 15 9.95e-01 0.000855 9.99e-01
GO:0031647 regulation of protein stability 57 9.91e-01 -0.000848 9.98e-01
GO:0030307 positive regulation of cell growth 36 9.96e-01 0.000436 9.99e-01
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 14 9.98e-01 -0.000416 9.99e-01
GO:0005874 microtubule 132 9.96e-01 -0.000274 9.99e-01
GO:0008340 determination of adult lifespan 21 9.98e-01 0.000261 9.99e-01
GO:0045724 positive regulation of cilium assembly 13 9.99e-01 -0.000208 9.99e-01
GO:0043539 protein serine/threonine kinase activator activity 34 9.99e-01 0.000143 9.99e-01
GO:0046332 SMAD binding 23 9.99e-01 0.000124 9.99e-01
GO:0006606 protein import into nucleus 62 9.99e-01 -0.000112 9.99e-01


Detailed Gene set reports



GO:0022625 cytosolic large ribosomal subunit
set GO:0022625 cytosolic large ribosomal subunit
setSize 40
pANOVA 3.57e-20
s.dist 0.84
p.adjustANOVA 2.11e-17


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL13 6917
RPL27 6784
RPLP1 6774
RPL35 6760
RPL9 6756
RPL7A 6722
RPL15 6714
RPL30 6703
RPL7 6695
RPL14 6677
RPL32 6668
RPL27A 6659
RPL3 6652
RPL10A 6566
RPL5 6563
RPL37 6544
RPLP0 6542
RPL34 6514
RPL18A 6504
RPL38 6501

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All member genes
GeneID Gene Rank
RPL13 6917
RPL27 6784
RPLP1 6774
RPL35 6760
RPL9 6756
RPL7A 6722
RPL15 6714
RPL30 6703
RPL7 6695
RPL14 6677
RPL32 6668
RPL27A 6659
RPL3 6652
RPL10A 6566
RPL5 6563
RPL37 6544
RPLP0 6542
RPL34 6514
RPL18A 6504
RPL38 6501
RPL8 6475
RPL11 6460
RPL29 6452
RPL35A 6338
RPL31 6304
RPLP2 6296
RPL7L1 6206
RPL26L1 6188
RPL37A 6102
RPL23 6079
RPL36 6066
RPL21 5933
RPL6 5856
RPL24 5761
RPL23A 5745
RPL19 5600
RPL12 5459
RPL4 3761
RPL3L -1861
ZCCHC17 -4869


GO:0002181 cytoplasmic translation
set GO:0002181 cytoplasmic translation
setSize 27
pANOVA 2.13e-13
s.dist 0.816
p.adjustANOVA 7.54e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPLP1 6774
RPL9 6756
RPS23 6730
RPL15 6714
RPS6 6692
RPL10A 6566
RPLP0 6542
RPL18A 6504
RPL38 6501
RPL8 6475
RPL29 6452
RPS14 6427
RPL35A 6338
RPL31 6304
RPL26L1 6188
RPL22 6169
RPL36 6066
RPL6 5856
RPL24 5761
DRG2 5749

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All member genes
GeneID Gene Rank
RPLP1 6774
RPL9 6756
RPS23 6730
RPL15 6714
RPS6 6692
RPL10A 6566
RPLP0 6542
RPL18A 6504
RPL38 6501
RPL8 6475
RPL29 6452
RPS14 6427
RPL35A 6338
RPL31 6304
RPL26L1 6188
RPL22 6169
RPL36 6066
RPL6 5856
RPL24 5761
DRG2 5749
RPS26 5304
RPS28 4924
SARS1 4611
RWDD1 4251
RPL22L1 4152
RPS29 3258
ZC3H15 -966


GO:0022627 cytosolic small ribosomal subunit
set GO:0022627 cytosolic small ribosomal subunit
setSize 25
pANOVA 4.06e-12
s.dist 0.801
p.adjustANOVA 1.03e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS15A 6933
RPS2 6915
RPS20 6842
RPS12 6828
RPS4Y1 6819
RPS21 6783
RPS7 6762
RPS23 6730
RPS13 6717
RPS3A 6711
RPS6 6692
RPS3 6603
RPS15 6602
RPS24 6499
RPS14 6427
RPS8 6395
RPS10 6387
RPS11 6369
RPS16 6276
RPS26 5304

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All member genes
GeneID Gene Rank
RPS15A 6933
RPS2 6915
RPS20 6842
RPS12 6828
RPS4Y1 6819
RPS21 6783
RPS7 6762
RPS23 6730
RPS13 6717
RPS3A 6711
RPS6 6692
RPS3 6603
RPS15 6602
RPS24 6499
RPS14 6427
RPS8 6395
RPS10 6387
RPS11 6369
RPS16 6276
RPS26 5304
RPS28 4924
RPS27L 4539
RPS29 3258
EIF2A 2121
LARP4 -7325


GO:0035145 exon-exon junction complex
set GO:0035145 exon-exon junction complex
setSize 10
pANOVA 3.17e-05
s.dist -0.76
p.adjustANOVA 0.00175


Top enriched genes
Top 20 genes
GeneID Gene Rank
SMG6 -7227
PNN -7185
SRSF1 -6955
UPF1 -6665
UPF2 -6618
CASC3 -6182
UPF3B -5356
THRAP3 -4367
TDRD3 -3974
UPF3A -2324

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMG6 -7227
PNN -7185
SRSF1 -6955
UPF1 -6665
UPF2 -6618
CASC3 -6182
UPF3B -5356
THRAP3 -4367
TDRD3 -3974
UPF3A -2324


GO:0140658 ATP-dependent chromatin remodeler activity
set GO:0140658 ATP-dependent chromatin remodeler activity
setSize 11
pANOVA 3.48e-05
s.dist -0.721
p.adjustANOVA 0.00183


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHD6 -7039
CHD7 -6915
CHD1 -6824
CHD2 -6646
CHD5 -6548
CHD1L -6158
CHD4 -5981
ERCC6 -5586
INO80 -4816
RAD54L2 -4363
SMARCAD1 1447

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHD6 -7039
CHD7 -6915
CHD1 -6824
CHD2 -6646
CHD5 -6548
CHD1L -6158
CHD4 -5981
ERCC6 -5586
INO80 -4816
RAD54L2 -4363
SMARCAD1 1447


GO:0003735 structural constituent of ribosome
set GO:0003735 structural constituent of ribosome
setSize 118
pANOVA 6.52e-38
s.dist 0.685
p.adjustANOVA 1.15e-34


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS15A 6933
RPL13 6917
RPS2 6915
RPS20 6842
RPS12 6828
RPS4Y1 6819
MRPL28 6810
RPL27 6784
RPS21 6783
RPLP1 6774
RPS7 6762
RPL35 6760
RPL9 6756
RPS23 6730
RPS13 6717
RPL15 6714
RPS3A 6711
RPL30 6703
RPL7 6695
RPS6 6692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS15A 6933
RPL13 6917
RPS2 6915
RPS20 6842
RPS12 6828
RPS4Y1 6819
MRPL28 6810
RPL27 6784
RPS21 6783
RPLP1 6774
RPS7 6762
RPL35 6760
RPL9 6756
RPS23 6730
RPS13 6717
RPL15 6714
RPS3A 6711
RPL30 6703
RPL7 6695
RPS6 6692
RPL14 6677
RPL32 6668
RPL27A 6659
RPL3 6652
RPS27A 6605
RPS3 6603
RPS15 6602
RPL10A 6566
RPL5 6563
RPL37 6544
RPLP0 6542
RPL34 6514
RPL18A 6504
RPL38 6501
RPS24 6499
RPL8 6475
RPL11 6460
RPL29 6452
RPS14 6427
RPS8 6395
RPS10 6387
MRPS34 6372
RPS11 6369
RPL35A 6338
MRPL37 6329
MRPS18A 6307
RPL31 6304
RPLP2 6296
RPS16 6276
MRPL24 6210
RPL7L1 6206
RPL26L1 6188
RPL22 6169
RPL37A 6102
RPL23 6079
RPL36 6066
MRPS15 6018
RPL21 5933
RPL6 5856
UBA52 5838
RPL24 5761
RPL23A 5745
RPS17 5698
RPL19 5600
MRPS22 5545
MRPS21 5535
MRPL51 5496
MRPL14 5473
RPL12 5459
MRPL36 5448
MRPS23 5416
RPS26 5304
MRPS12 5215
MRPL21 5191
MRPS17 5155
MRPL13 5070
RPS28 4924
MRPL35 4744
MRPL2 4686
DAP3 4661
RPS27L 4539
MRPS6 4507
MRPL16 4392
SRBD1 4297
MRPL18 4198
MRPL17 4172
RPL22L1 4152
MRPS9 4085
MRPL23 4001
MRPS18C 3771
RPL4 3761
MRPS5 3748
DDA1 3532
MRPS11 3329
RPS29 3258
MRPS31 3100
MRPL47 2969
MRPL3 2828
MRPL32 2790
MRPL12 2358
MRPL27 2247
MRPL19 1819
MRPL41 1542
MRPS16 1433
MRPL22 732
MRPL15 579
MRPS25 477
MRPS7 469
MRPL49 -555
MRPS2 -623
MRPS30 -624
MRPL20 -1815
RPL3L -1861
MRPS35 -1904
MRPS14 -2348
MRPS10 -4576
MRPL10 -4836
MRPL46 -5920


GO:0008137 NADH dehydrogenase (ubiquinone) activity
set GO:0008137 NADH dehydrogenase (ubiquinone) activity
setSize 10
pANOVA 0.000298
s.dist 0.661
p.adjustANOVA 0.0105


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFS3 6705
ND5 6402
NDUFS8 6213
ND2 6117
NDUFA10 5114
NDUFS1 4706
NDUFV2 4604
NDUFS2 3934
NDUFS7 1181
NDUFV1 609

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All member genes
GeneID Gene Rank
NDUFS3 6705
ND5 6402
NDUFS8 6213
ND2 6117
NDUFA10 5114
NDUFS1 4706
NDUFV2 4604
NDUFS2 3934
NDUFS7 1181
NDUFV1 609


GO:0045271 respiratory chain complex I
set GO:0045271 respiratory chain complex I
setSize 31
pANOVA 2.34e-10
s.dist 0.657
p.adjustANOVA 4.6e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFAB1 6976
NDUFS3 6705
NDUFB8 6649
ND5 6402
NDUFB6 6374
NDUFS8 6213
ND2 6117
NDUFB5 5975
NDUFB10 5966
NDUFB9 5541
NDUFA12 5531
NDUFB3 5405
NDUFA8 5396
NDUFS4 5389
NDUFA10 5114
NDUFA13 5088
NDUFA5 5082
NDUFS1 4706
NDUFC2 4662
NDUFV2 4604

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All member genes
GeneID Gene Rank
NDUFAB1 6976
NDUFS3 6705
NDUFB8 6649
ND5 6402
NDUFB6 6374
NDUFS8 6213
ND2 6117
NDUFB5 5975
NDUFB10 5966
NDUFB9 5541
NDUFA12 5531
NDUFB3 5405
NDUFA8 5396
NDUFS4 5389
NDUFA10 5114
NDUFA13 5088
NDUFA5 5082
NDUFS1 4706
NDUFC2 4662
NDUFV2 4604
NDUFA6 4483
NDUFS2 3934
NDUFB2 3365
NDUFA9 3109
NDUFA2 3023
NDUFV3 2794
NDUFS6 2190
NDUFS5 2181
NDUFS7 1181
NDUFV1 609
NDUFB4 -361


GO:0006120 mitochondrial electron transport, NADH to ubiquinone
set GO:0006120 mitochondrial electron transport, NADH to ubiquinone
setSize 19
pANOVA 7.94e-07
s.dist 0.654
p.adjustANOVA 7.41e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFS3 6705
NDUFB8 6649
ND5 6402
NDUFB6 6374
NDUFS8 6213
ND2 6117
NDUFAF1 5731
NDUFB9 5541
NDUFA8 5396
NDUFA10 5114
NDUFS1 4706
NDUFC2 4662
NDUFV2 4604
NDUFS2 3934
DNAJC15 2718
NDUFS6 2190
NDUFS7 1181
DLD 823
NDUFV1 609

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All member genes
GeneID Gene Rank
NDUFS3 6705
NDUFB8 6649
ND5 6402
NDUFB6 6374
NDUFS8 6213
ND2 6117
NDUFAF1 5731
NDUFB9 5541
NDUFA8 5396
NDUFA10 5114
NDUFS1 4706
NDUFC2 4662
NDUFV2 4604
NDUFS2 3934
DNAJC15 2718
NDUFS6 2190
NDUFS7 1181
DLD 823
NDUFV1 609


GO:0006749 glutathione metabolic process
set GO:0006749 glutathione metabolic process
setSize 15
pANOVA 1.38e-05
s.dist 0.648
p.adjustANOVA 0.000841


Top enriched genes
Top 20 genes
GeneID Gene Rank
HAGH 6957
GSTO2 6903
HPGDS 6895
ARL6IP5 6767
TXNRD3 6259
GSTT1 5646
GSTM2 5497
GSR 4466
SLC7A11 4418
GSTK1 4320
GPX1 4076
SOD1 3884
GSTZ1 1986
MMACHC -188
CTNS -864

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All member genes
GeneID Gene Rank
HAGH 6957
GSTO2 6903
HPGDS 6895
ARL6IP5 6767
TXNRD3 6259
GSTT1 5646
GSTM2 5497
GSR 4466
SLC7A11 4418
GSTK1 4320
GPX1 4076
SOD1 3884
GSTZ1 1986
MMACHC -188
CTNS -864


GO:0004602 glutathione peroxidase activity
set GO:0004602 glutathione peroxidase activity
setSize 12
pANOVA 0.000105
s.dist 0.647
p.adjustANOVA 0.00453


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX3 6796
GPX7 6565
CLIC2 6348
MGST3 6323
MGST1 5696
PRDX6 5550
GPX4 5409
GSTK1 4320
GPX1 4076
PTGES 2520
GPX8 1170
CP -1284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX3 6796
GPX7 6565
CLIC2 6348
MGST3 6323
MGST1 5696
PRDX6 5550
GPX4 5409
GSTK1 4320
GPX1 4076
PTGES 2520
GPX8 1170
CP -1284


GO:0004364 glutathione transferase activity
set GO:0004364 glutathione transferase activity
setSize 10
pANOVA 0.000509
s.dist 0.635
p.adjustANOVA 0.0167


Top enriched genes
Top 20 genes
GeneID Gene Rank
GSTO2 6903
HPGDS 6895
MGST3 6323
MGST1 5696
GSTT1 5646
GSTM2 5497
GSTK1 4320
PTGES 2520
GSTZ1 1986
LANCL1 -2060

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All member genes
GeneID Gene Rank
GSTO2 6903
HPGDS 6895
MGST3 6323
MGST1 5696
GSTT1 5646
GSTM2 5497
GSTK1 4320
PTGES 2520
GSTZ1 1986
LANCL1 -2060


GO:0006412 translation
set GO:0006412 translation
setSize 96
pANOVA 6.03e-24
s.dist 0.596
p.adjustANOVA 5.34e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS15A 6933
RPL13 6917
RPS2 6915
RPS20 6842
RPS4Y1 6819
RPL27 6784
RPS21 6783
RPS7 6762
RPL35 6760
GSPT2 6755
RPS23 6730
RPS13 6717
RPS3A 6711
RPL14 6677
RPL32 6668
RPL27A 6659
RPL3 6652
RPS27A 6605
RPS3 6603
RPS15 6602

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS15A 6933
RPL13 6917
RPS2 6915
RPS20 6842
RPS4Y1 6819
RPL27 6784
RPS21 6783
RPS7 6762
RPL35 6760
GSPT2 6755
RPS23 6730
RPS13 6717
RPS3A 6711
RPL14 6677
RPL32 6668
RPL27A 6659
RPL3 6652
RPS27A 6605
RPS3 6603
RPS15 6602
RPL5 6563
RPL37 6544
RPL34 6514
RPS24 6499
RPL11 6460
RPS14 6427
RPS8 6395
RPS11 6369
RPL35A 6338
MRPL37 6329
MRPS18A 6307
RPS16 6276
MRPL24 6210
RPL26L1 6188
RPL22 6169
RPL37A 6102
RPL23 6079
MRPS15 6018
RPL21 5933
UBA52 5838
RPL23A 5745
RPS17 5698
RPL19 5600
MRPS21 5535
MRPL51 5496
MRPL14 5473
RPL12 5459
MRPL36 5448
MRPS23 5416
MRPS12 5215
MRPS17 5155
MRPL13 5070
MRPL35 4744
MRPL2 4686
RPS27L 4539
MRPS6 4507
MRPL16 4392
SRBD1 4297
MRPL18 4198
MRPL17 4172
RPL22L1 4152
MRPS9 4085
GUF1 3860
MRPS18C 3771
RPL4 3761
MRPS5 3748
DDA1 3532
MRPS11 3329
RPS29 3258
EIF2AK2 3122
MRPL47 2969
MRPL3 2828
MRPL32 2790
MRPL12 2358
MRPL27 2247
MRPL19 1819
MRPL41 1542
MRPS16 1433
C2H6orf52 986
MRPL22 732
TRNAU1AP 691
MRPL15 579
MRPS7 469
CPEB3 1
MRPL33 -435
MRPL49 -555
MRPS2 -623
MRPS30 -624
CPEB4 -934
MRPL20 -1815
RPL3L -1861
MRPS14 -2348
MRPS10 -4576
MRPL10 -4836
HBS1L -5080
EIF4ENIF1 -5476


GO:0000245 spliceosomal complex assembly
set GO:0000245 spliceosomal complex assembly
setSize 10
pANOVA 0.0015
s.dist -0.58
p.adjustANOVA 0.0351


Top enriched genes
Top 20 genes
GeneID Gene Rank
SCAF11 -7038
RBM10 -7031
RSRP1 -6930
SRPK1 -5923
SF3B1 -5470
USP39 -3090
ZRSR2 -3011
PRPF19 -2541
SF3A2 -2514
SRPK2 -332

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All member genes
GeneID Gene Rank
SCAF11 -7038
RBM10 -7031
RSRP1 -6930
SRPK1 -5923
SF3B1 -5470
USP39 -3090
ZRSR2 -3011
PRPF19 -2541
SF3A2 -2514
SRPK2 -332


GO:1902774 late endosome to lysosome transport
set GO:1902774 late endosome to lysosome transport
setSize 10
pANOVA 0.00154
s.dist 0.578
p.adjustANOVA 0.0351


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHMP4C 6962
CHMP2B 6328
VPS39 5936
CHMP1B 5692
CHMP5 5186
VPS41 4338
CHMP3 3435
CHMP7 2996
C9orf72 1848
CHMP2A -3057

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All member genes
GeneID Gene Rank
CHMP4C 6962
CHMP2B 6328
VPS39 5936
CHMP1B 5692
CHMP5 5186
VPS41 4338
CHMP3 3435
CHMP7 2996
C9orf72 1848
CHMP2A -3057


GO:1990391 DNA repair complex
set GO:1990391 DNA repair complex
setSize 10
pANOVA 0.00172
s.dist -0.573
p.adjustANOVA 0.038


Top enriched genes
Top 20 genes
GeneID Gene Rank
FANCI -7298
ASCC2 -7226
TP53BP1 -7073
KDM1A -6799
ATM -6528
BRCA1 -6435
FANCD2 -5008
BRCA2 -4067
PHF21A 3136
PALB2 3949

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All member genes
GeneID Gene Rank
FANCI -7298
ASCC2 -7226
TP53BP1 -7073
KDM1A -6799
ATM -6528
BRCA1 -6435
FANCD2 -5008
BRCA2 -4067
PHF21A 3136
PALB2 3949


GO:0032981 mitochondrial respiratory chain complex I assembly
set GO:0032981 mitochondrial respiratory chain complex I assembly
setSize 38
pANOVA 2.15e-09
s.dist 0.561
p.adjustANOVA 3.8e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFAB1 6976
NDUFS3 6705
NDUFB8 6649
ND5 6402
NDUFB6 6374
NDUFS8 6213
ND2 6117
NDUFB5 5975
NDUFB10 5966
NDUFAF1 5731
NDUFB9 5541
NDUFA12 5531
NDUFB3 5405
NDUFA8 5396
TIMM21 5225
NDUFA10 5114
NDUFA5 5082
NDUFAF4 4845
NDUFS1 4706
NDUFC2 4662

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFAB1 6976
NDUFS3 6705
NDUFB8 6649
ND5 6402
NDUFB6 6374
NDUFS8 6213
ND2 6117
NDUFB5 5975
NDUFB10 5966
NDUFAF1 5731
NDUFB9 5541
NDUFA12 5531
NDUFB3 5405
NDUFA8 5396
TIMM21 5225
NDUFA10 5114
NDUFA5 5082
NDUFAF4 4845
NDUFS1 4706
NDUFC2 4662
NDUFAF2 4634
NDUFA6 4483
NDUFS2 3934
NDUFB2 3365
NDUFAF7 3348
NDUFA9 3109
NUBPL 2713
NDUFAF5 2643
NDUFS5 2181
NDUFAF8 1651
TIMMDC1 1599
NDUFS7 1181
BCS1L 843
NDUFAF6 456
NDUFAF3 189
FOXRED1 -224
NDUFB4 -361
TMEM186 -4691


GO:0007042 lysosomal lumen acidification
set GO:0007042 lysosomal lumen acidification
setSize 10
pANOVA 0.0023
s.dist 0.557
p.adjustANOVA 0.0463


Top enriched genes
Top 20 genes
GeneID Gene Rank
CREG1 6724
ATP6AP2 6208
CLN6 5956
LAMP1 5894
TMEM106B 5266
TMEM9 4971
LAMP2 4031
PPT1 3904
TMEM199 2382
CLN5 -7245

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All member genes
GeneID Gene Rank
CREG1 6724
ATP6AP2 6208
CLN6 5956
LAMP1 5894
TMEM106B 5266
TMEM9 4971
LAMP2 4031
PPT1 3904
TMEM199 2382
CLN5 -7245


GO:0045116 protein neddylation
set GO:0045116 protein neddylation
setSize 10
pANOVA 0.00245
s.dist 0.553
p.adjustANOVA 0.0475


Top enriched genes
Top 20 genes
GeneID Gene Rank
NEDD8 6865
DCUN1D5 6271
UBE2F 6081
DCUN1D4 5704
RBX1 5476
UBA3 3346
DCUN1D3 3343
RNF7 629
NAE1 567
DCUN1D2 -443

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEDD8 6865
DCUN1D5 6271
UBE2F 6081
DCUN1D4 5704
RBX1 5476
UBA3 3346
DCUN1D3 3343
RNF7 629
NAE1 567
DCUN1D2 -443


GO:0098869 cellular oxidant detoxification
set GO:0098869 cellular oxidant detoxification
setSize 28
pANOVA 5.66e-07
s.dist 0.546
p.adjustANOVA 5.57e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
GSTO2 6903
GPX3 6796
GPX7 6565
MGST3 6323
TXNRD3 6259
MGST1 5696
TP53INP1 5563
PRDX6 5550
SELENOW 5481
GPX4 5409
SELENOT 5123
PRDX3 5052
GSR 4466
GSTK1 4320
PRDX4 4252
SRXN1 4173
GPX1 4076
PXDN 4070
SESN1 3356
TXNRD1 2923

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GSTO2 6903
GPX3 6796
GPX7 6565
MGST3 6323
TXNRD3 6259
MGST1 5696
TP53INP1 5563
PRDX6 5550
SELENOW 5481
GPX4 5409
SELENOT 5123
PRDX3 5052
GSR 4466
GSTK1 4320
PRDX4 4252
SRXN1 4173
GPX1 4076
PXDN 4070
SESN1 3356
TXNRD1 2923
PTGES 2520
TXNRD2 1374
NXN 1216
GPX8 1170
SESN2 870
PRXL2A -599
CP -1284
EPX -3230


GO:0034314 Arp2/3 complex-mediated actin nucleation
set GO:0034314 Arp2/3 complex-mediated actin nucleation
setSize 11
pANOVA 0.00218
s.dist 0.534
p.adjustANOVA 0.0454


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC1A 6981
ARPC1B 6936
ARPC4 6314
ARPC3 6204
ARPC5 5712
WASHC1 4222
ARPC2 3849
ACTR3 3108
JMY 809
ARPC5L -1556
WHAMM -2508

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC1A 6981
ARPC1B 6936
ARPC4 6314
ARPC3 6204
ARPC5 5712
WASHC1 4222
ARPC2 3849
ACTR3 3108
JMY 809
ARPC5L -1556
WHAMM -2508


GO:0042474 middle ear morphogenesis
set GO:0042474 middle ear morphogenesis
setSize 10
pANOVA 0.00372
s.dist 0.53
p.adjustANOVA 0.0604


Top enriched genes
Top 20 genes
GeneID Gene Rank
NKX3-2 6813
RPL38 6501
OSR2 5635
INSIG1 5387
FGFR1 5011
PRRX1 2918
OSR1 2323
INSIG2 1697
NAGLU 991
TSHZ1 -1118

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NKX3-2 6813
RPL38 6501
OSR2 5635
INSIG1 5387
FGFR1 5011
PRRX1 2918
OSR1 2323
INSIG2 1697
NAGLU 991
TSHZ1 -1118


GO:1903543 positive regulation of exosomal secretion
set GO:1903543 positive regulation of exosomal secretion
setSize 10
pANOVA 0.0039
s.dist 0.527
p.adjustANOVA 0.0623


Top enriched genes
Top 20 genes
GeneID Gene Rank
SDC4 6994
SDCBP 6902
VPS4A 6531
RAB7A 6297
SDC1 4840
SNF8 3350
STAM 3054
HGS 1014
VPS4B 29
CHMP2A -3057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SDC4 6994
SDCBP 6902
VPS4A 6531
RAB7A 6297
SDC1 4840
SNF8 3350
STAM 3054
HGS 1014
VPS4B 29
CHMP2A -3057


GO:0032585 multivesicular body membrane
set GO:0032585 multivesicular body membrane
setSize 12
pANOVA 0.00164
s.dist 0.525
p.adjustANOVA 0.0368


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHMP4C 6962
CHMP2B 6328
CD63 6251
CHMP1B 5692
CHMP5 5186
TMEM9 4971
RAB27A 4299
CHMP3 3435
CHMP7 2996
SLC9A8 1129
SORL1 -1235
CHMP2A -3057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHMP4C 6962
CHMP2B 6328
CD63 6251
CHMP1B 5692
CHMP5 5186
TMEM9 4971
RAB27A 4299
CHMP3 3435
CHMP7 2996
SLC9A8 1129
SORL1 -1235
CHMP2A -3057


GO:0005852 eukaryotic translation initiation factor 3 complex
set GO:0005852 eukaryotic translation initiation factor 3 complex
setSize 10
pANOVA 0.00418
s.dist 0.523
p.adjustANOVA 0.065


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3H 6794
EIF3E 6472
EIF3M 5706
EIF3K 5493
EIF3B 5491
EIF3G 4632
EIF3L 4374
EIF3D 4123
EIF3F -119
EIF3J -7293

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3H 6794
EIF3E 6472
EIF3M 5706
EIF3K 5493
EIF3B 5491
EIF3G 4632
EIF3L 4374
EIF3D 4123
EIF3F -119
EIF3J -7293


GO:0030992 intraciliary transport particle B
set GO:0030992 intraciliary transport particle B
setSize 15
pANOVA 0.000684
s.dist 0.506
p.adjustANOVA 0.0205


Top enriched genes
Top 20 genes
GeneID Gene Rank
IFT27 6614
IFT46 6611
IFT20 6207
TRIM59 6130
IFT52 5903
IFT80 5351
HSPB11 5326
IFT22 3518
TRAF3IP1 2814
IFT74 2521
IFT57 2446
IFT81 2343
IFT88 2297
IFT172 -2598
UBXN10 -3795

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFT27 6614
IFT46 6611
IFT20 6207
TRIM59 6130
IFT52 5903
IFT80 5351
HSPB11 5326
IFT22 3518
TRAF3IP1 2814
IFT74 2521
IFT57 2446
IFT81 2343
IFT88 2297
IFT172 -2598
UBXN10 -3795


GO:0005840 ribosome
set GO:0005840 ribosome
setSize 43
pANOVA 1.16e-08
s.dist 0.503
p.adjustANOVA 1.47e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS4Y1 6819
RPL27 6784
RPS21 6783
RPLP1 6774
RPS23 6730
RPL30 6703
RPL32 6668
RACK1 6640
RPS27A 6605
RPL34 6514
SLC37A4 6489
RPL11 6460
MRPL24 6210
RPL22 6169
UBA52 5838
RPS17 5698
PSMA6 5548
MRPS21 5535
MRPS33 5517
MRPS23 5416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS4Y1 6819
RPL27 6784
RPS21 6783
RPLP1 6774
RPS23 6730
RPL30 6703
RPL32 6668
RACK1 6640
RPS27A 6605
RPL34 6514
SLC37A4 6489
RPL11 6460
MRPL24 6210
RPL22 6169
UBA52 5838
RPS17 5698
PSMA6 5548
MRPS21 5535
MRPS33 5517
MRPS23 5416
MRPS12 5215
MRPL13 5070
MRPL35 4744
EEF2 4576
MRPL1 4560
MRPS6 4507
MRPL18 4198
RPL22L1 4152
MRPS9 4085
MRPS18C 3771
DDA1 3532
RPS29 3258
FXR1 766
MRPS25 477
MRPS7 469
MRPL33 -435
MRPL45 -550
GADD45GIP1 -3500
PTCD3 -4078
HSPA14 -5158
NUFIP2 -5796
MRPL46 -5920
EIF4G1 -7111


GO:0001732 formation of cytoplasmic translation initiation complex
set GO:0001732 formation of cytoplasmic translation initiation complex
setSize 12
pANOVA 0.00277
s.dist 0.499
p.adjustANOVA 0.0521


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3H 6794
EIF3E 6472
EIF3M 5706
EIF3K 5493
EIF3B 5491
EIF3I 5354
EIF3G 4632
EIF3L 4374
EIF3D 4123
EIF3F -119
EIF5 -317
EIF3J -7293

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3H 6794
EIF3E 6472
EIF3M 5706
EIF3K 5493
EIF3B 5491
EIF3I 5354
EIF3G 4632
EIF3L 4374
EIF3D 4123
EIF3F -119
EIF5 -317
EIF3J -7293


GO:0000422 autophagy of mitochondrion
set GO:0000422 autophagy of mitochondrion
setSize 14
pANOVA 0.00135
s.dist 0.495
p.adjustANOVA 0.0326


Top enriched genes
Top 20 genes
GeneID Gene Rank
WIPI2 6906
FBXO7 6419
WIPI1 6290
RB1CC1 6016
CISD2 5757
MAP1LC3A 5527
ATG3 5360
FUNDC1 3540
USP30 2852
WDR45 1472
PINK1 993
FUNDC2 962
WDR45B -407
FBXL4 -4609

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WIPI2 6906
FBXO7 6419
WIPI1 6290
RB1CC1 6016
CISD2 5757
MAP1LC3A 5527
ATG3 5360
FUNDC1 3540
USP30 2852
WDR45 1472
PINK1 993
FUNDC2 962
WDR45B -407
FBXL4 -4609


GO:0019003 GDP binding
set GO:0019003 GDP binding
setSize 44
pANOVA 2.14e-08
s.dist 0.488
p.adjustANOVA 2.52e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
IFT27 6614
RAP2A 6585
GEM 6363
ARF6 6356
RAB14 6327
RAB7A 6297
RAP2B 6230
HRAS 6221
RAB5C 6071
DNM1 6067
RAB5A 5892
MRAS 5866
RAB31 5815
RAB28 5733
RAB18 5725
RAB21 5653
RRAGD 5507
RAP1B 5094
DYNC1LI1 5032
RAB27A 4299

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFT27 6614
RAP2A 6585
GEM 6363
ARF6 6356
RAB14 6327
RAB7A 6297
RAP2B 6230
HRAS 6221
RAB5C 6071
DNM1 6067
RAB5A 5892
MRAS 5866
RAB31 5815
RAB28 5733
RAB18 5725
RAB21 5653
RRAGD 5507
RAP1B 5094
DYNC1LI1 5032
RAB27A 4299
RAB7L1 4257
RAB5B 4020
RRAS 3945
NRAS 3894
RAB4A 3864
SRP54 3523
RAB8A 3406
KRAS 3402
GNAI1 3271
RAB9A 3196
RAB9B 2875
RAN 2829
RAB35 2748
RALA 2722
RAB22A 2310
ARL8B 1803
RAB10 -1022
DIRAS2 -1035
TRIM23 -1693
RALB -1714
RAB8B -2420
RIT1 -4354
RRAGC -5290
MIEF1 -6836


GO:0060047 heart contraction
set GO:0060047 heart contraction
setSize 10
pANOVA 0.00779
s.dist 0.486
p.adjustANOVA 0.101


Top enriched genes
Top 20 genes
GeneID Gene Rank
CDC42 6700
DNM1L 5526
ATG5 5355
EXT1 5210
GATA6 4095
GPX1 4076
SOD1 3884
EXT2 3595
SGCD 1608
ATP1A1 -7057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC42 6700
DNM1L 5526
ATG5 5355
EXT1 5210
GATA6 4095
GPX1 4076
SOD1 3884
EXT2 3595
SGCD 1608
ATP1A1 -7057


GO:1905564 positive regulation of vascular endothelial cell proliferation
set GO:1905564 positive regulation of vascular endothelial cell proliferation
setSize 10
pANOVA 0.0086
s.dist 0.48
p.adjustANOVA 0.108


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA4 6853
PDPK1 5947
FGFR1 5011
PLCG1 4437
NRARP 3655
IGF2 3475
SIRT6 2908
SP1 2569
AKT3 342
STAT3 -2644

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA4 6853
PDPK1 5947
FGFR1 5011
PLCG1 4437
NRARP 3655
IGF2 3475
SIRT6 2908
SP1 2569
AKT3 342
STAT3 -2644


GO:0055074 calcium ion homeostasis
set GO:0055074 calcium ion homeostasis
setSize 18
pANOVA 0.000429
s.dist 0.479
p.adjustANOVA 0.0146


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITPR3 6434
PSEN2 6280
ANXA6 6238
ANXA5 6235
WFS1 6056
ANKH 5390
ALPL 5227
ANXA2 5183
FGFR1 5011
TMTC2 2979
WNK4 2689
CIB3 2678
SNX10 1956
SGCD 1608
TRIM24 846
CIB2 -763
SELENON -1926
PSEN1 -3616

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR3 6434
PSEN2 6280
ANXA6 6238
ANXA5 6235
WFS1 6056
ANKH 5390
ALPL 5227
ANXA2 5183
FGFR1 5011
TMTC2 2979
WNK4 2689
CIB3 2678
SNX10 1956
SGCD 1608
TRIM24 846
CIB2 -763
SELENON -1926
PSEN1 -3616


GO:0009888 tissue development
set GO:0009888 tissue development
setSize 18
pANOVA 0.000544
s.dist -0.471
p.adjustANOVA 0.0175


Top enriched genes
Top 20 genes
GeneID Gene Rank
NTN4 -7312
NTNG2 -6909
LAMC2 -6796
ACVR1B -6613
POSTN -6560
LAMA5 -6116
DHCR24 -6043
LAMA3 -5647
LAMC1 -4673
GAA -4625
NTN3 -4180
LAMB1 -3704
ACVR1C -3690
SMO -707
LAMA2 -625
USH2A -175
LAMB3 3553
LAMB2 6037

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NTN4 -7312
NTNG2 -6909
LAMC2 -6796
ACVR1B -6613
POSTN -6560
LAMA5 -6116
DHCR24 -6043
LAMA3 -5647
LAMC1 -4673
GAA -4625
NTN3 -4180
LAMB1 -3704
ACVR1C -3690
SMO -707
LAMA2 -625
USH2A -175
LAMB3 3553
LAMB2 6037


GO:0022604 regulation of cell morphogenesis
set GO:0022604 regulation of cell morphogenesis
setSize 14
pANOVA 0.0024
s.dist -0.469
p.adjustANOVA 0.0473


Top enriched genes
Top 20 genes
GeneID Gene Rank
LARP4 -7325
PHIP -7158
BCL9L -6973
CAMSAP1 -6726
ZRANB1 -5887
PDZD8 -5718
ZMYM4 -5627
FERMT2 -4506
ZMYM3 -4480
WTIP -3457
STRIP1 1046
EFNA5 1519
CAPZB 2154
FMNL2 2965

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LARP4 -7325
PHIP -7158
BCL9L -6973
CAMSAP1 -6726
ZRANB1 -5887
PDZD8 -5718
ZMYM4 -5627
FERMT2 -4506
ZMYM3 -4480
WTIP -3457
STRIP1 1046
EFNA5 1519
CAPZB 2154
FMNL2 2965


GO:1904294 positive regulation of ERAD pathway
set GO:1904294 positive regulation of ERAD pathway
setSize 10
pANOVA 0.0103
s.dist 0.468
p.adjustANOVA 0.116


Top enriched genes
Top 20 genes
GeneID Gene Rank
CAV1 6916
HERPUD1 6440
WFS1 6056
UBQLN1 6024
STUB1 5594
SGTA 3220
TMEM259 2042
RNFT1 1480
USP13 -2859
RNFT2 -3195

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAV1 6916
HERPUD1 6440
WFS1 6056
UBQLN1 6024
STUB1 5594
SGTA 3220
TMEM259 2042
RNFT1 1480
USP13 -2859
RNFT2 -3195


GO:0004683 calcium/calmodulin-dependent protein kinase activity
set GO:0004683 calcium/calmodulin-dependent protein kinase activity
setSize 11
pANOVA 0.00753
s.dist 0.465
p.adjustANOVA 0.0995


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPKAPK2 6931
CAMK2D 5991
CAMK2G 5079
MAPKAPK3 4802
MYLK3 4143
CAMK1 4102
CAMK2A 2684
CAMK1G 1245
MAPKAPK5 985
MKNK2 254
DAPK1 -1561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPKAPK2 6931
CAMK2D 5991
CAMK2G 5079
MAPKAPK3 4802
MYLK3 4143
CAMK1 4102
CAMK2A 2684
CAMK1G 1245
MAPKAPK5 985
MKNK2 254
DAPK1 -1561


GO:1903076 regulation of protein localization to plasma membrane
set GO:1903076 regulation of protein localization to plasma membrane
setSize 18
pANOVA 0.000651
s.dist 0.464
p.adjustANOVA 0.0199


Top enriched genes
Top 20 genes
GeneID Gene Rank
SDC4 6994
STX7 6683
VPS4A 6531
VTI1B 6196
CAMK2D 5991
AR 5930
ZDHHC7 5543
CAMK2G 5079
LDLRAP1 4922
MAPKAPK3 4802
STX8 4180
SIRT6 2908
CAMK2A 2684
ZDHHC2 2256
PIK3R1 -153
NHLRC1 -3234
EPM2A -4556
PIK3R2 -6229

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SDC4 6994
STX7 6683
VPS4A 6531
VTI1B 6196
CAMK2D 5991
AR 5930
ZDHHC7 5543
CAMK2G 5079
LDLRAP1 4922
MAPKAPK3 4802
STX8 4180
SIRT6 2908
CAMK2A 2684
ZDHHC2 2256
PIK3R1 -153
NHLRC1 -3234
EPM2A -4556
PIK3R2 -6229


GO:0090443 FAR/SIN/STRIPAK complex
set GO:0090443 FAR/SIN/STRIPAK complex
setSize 12
pANOVA 0.00562
s.dist 0.462
p.adjustANOVA 0.0812


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP2CB 5953
PDCD10 5464
SIKE1 5318
STK26 4557
PPP2CA 3812
STRN 3756
MOB4 3187
STK24 1885
STK25 1214
STRN3 1213
STRIP1 1046
CTTNBP2NL 81

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2CB 5953
PDCD10 5464
SIKE1 5318
STK26 4557
PPP2CA 3812
STRN 3756
MOB4 3187
STK24 1885
STK25 1214
STRN3 1213
STRIP1 1046
CTTNBP2NL 81


GO:0003925 G protein activity
set GO:0003925 G protein activity
setSize 18
pANOVA 0.000716
s.dist 0.461
p.adjustANOVA 0.0211


Top enriched genes
Top 20 genes
GeneID Gene Rank
CDC42 6700
RAP2A 6585
HRAS 6221
RAB5C 6071
SAR1B 5854
GNA12 5132
RAP1B 5094
RAB5B 4020
NRAS 3894
GNAI1 3271
RAN 2829
RALA 2722
GNAQ 2120
ARL8B 1803
RAB11A 695
RAB10 -1022
GNA11 -1166
GNA13 -4756

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC42 6700
RAP2A 6585
HRAS 6221
RAB5C 6071
SAR1B 5854
GNA12 5132
RAP1B 5094
RAB5B 4020
NRAS 3894
GNAI1 3271
RAN 2829
RALA 2722
GNAQ 2120
ARL8B 1803
RAB11A 695
RAB10 -1022
GNA11 -1166
GNA13 -4756


GO:0070577 lysine-acetylated histone binding
set GO:0070577 lysine-acetylated histone binding
setSize 16
pANOVA 0.00155
s.dist -0.457
p.adjustANOVA 0.0351


Top enriched genes
Top 20 genes
GeneID Gene Rank
MLLT1 -7344
BRD2 -7208
PHIP -7158
ATAD2B -6666
BRPF3 -6429
ZZEF1 -5494
PSME4 -5249
DPF2 -4809
BRD3 -4431
ZZZ3 -4231
ZMYND8 -3643
KMT2A -2329
BRD9 311
TRIM24 846
BRD7 2312
MLLT3 5505

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MLLT1 -7344
BRD2 -7208
PHIP -7158
ATAD2B -6666
BRPF3 -6429
ZZEF1 -5494
PSME4 -5249
DPF2 -4809
BRD3 -4431
ZZZ3 -4231
ZMYND8 -3643
KMT2A -2329
BRD9 311
TRIM24 846
BRD7 2312
MLLT3 5505


GO:0006744 ubiquinone biosynthetic process
set GO:0006744 ubiquinone biosynthetic process
setSize 11
pANOVA 0.00877
s.dist 0.456
p.adjustANOVA 0.108


Top enriched genes
Top 20 genes
GeneID Gene Rank
COQ7 6309
COQ9 5970
COQ6 5937
COQ3 4994
COQ4 4811
PDSS1 4007
COQ5 3643
PDSS2 3508
NDUFA9 3109
COQ8A -3842
RTN4IP1 -4501

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COQ7 6309
COQ9 5970
COQ6 5937
COQ3 4994
COQ4 4811
PDSS1 4007
COQ5 3643
PDSS2 3508
NDUFA9 3109
COQ8A -3842
RTN4IP1 -4501


GO:0016442 RISC complex
set GO:0016442 RISC complex
setSize 11
pANOVA 0.00909
s.dist -0.454
p.adjustANOVA 0.108


Top enriched genes
Top 20 genes
GeneID Gene Rank
XPO5 -7128
TNRC6A -6601
DICER1 -5528
DCP2 -5282
AGO3 -5266
DDX6 -5217
AGO2 -4182
TARBP2 -3374
AGO4 -2919
LIMD1 2472
EIF4E 4728

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
XPO5 -7128
TNRC6A -6601
DICER1 -5528
DCP2 -5282
AGO3 -5266
DDX6 -5217
AGO2 -4182
TARBP2 -3374
AGO4 -2919
LIMD1 2472
EIF4E 4728


GO:0036121 double-stranded DNA helicase activity
set GO:0036121 double-stranded DNA helicase activity
setSize 11
pANOVA 0.00927
s.dist -0.453
p.adjustANOVA 0.108


Top enriched genes
Top 20 genes
GeneID Gene Rank
TWNK -7383
CHD7 -6915
CHD1 -6824
BLM -6673
UPF1 -6665
IGHMBP2 -4274
ERCC3 -1585
MCM9 -1478
MCM3 -1454
MCM8 2061
MCM5 2989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TWNK -7383
CHD7 -6915
CHD1 -6824
BLM -6673
UPF1 -6665
IGHMBP2 -4274
ERCC3 -1585
MCM9 -1478
MCM3 -1454
MCM8 2061
MCM5 2989


GO:0030904 retromer complex
set GO:0030904 retromer complex
setSize 15
pANOVA 0.00247
s.dist 0.451
p.adjustANOVA 0.0475


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAB7A 6297
VPS29L 6110
VPS35 6033
SNX8 5913
SNX32 5823
TBC1D5 5751
SNX3 5446
SNX5 4786
VPS29 3735
SNX12 2751
DENND5A 700
DENND4C 247
SNX27 -508
VPS26A -2173
VPS26B -5172

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAB7A 6297
VPS29L 6110
VPS35 6033
SNX8 5913
SNX32 5823
TBC1D5 5751
SNX3 5446
SNX5 4786
VPS29 3735
SNX12 2751
DENND5A 700
DENND4C 247
SNX27 -508
VPS26A -2173
VPS26B -5172


GO:0048041 focal adhesion assembly
set GO:0048041 focal adhesion assembly
setSize 14
pANOVA 0.00354
s.dist -0.45
p.adjustANOVA 0.0588


Top enriched genes
Top 20 genes
GeneID Gene Rank
FN1 -7395
PEAK1 -7174
PIP5K1A -7008
PTPRK -6398
SRC -5344
BCL2 -5341
FERMT2 -4506
BCR -4477
THY1 -2766
CDH11 -2517
WHAMM -2508
RCC2 -774
CORO2B 888
ARHGAP6 7000

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FN1 -7395
PEAK1 -7174
PIP5K1A -7008
PTPRK -6398
SRC -5344
BCL2 -5341
FERMT2 -4506
BCR -4477
THY1 -2766
CDH11 -2517
WHAMM -2508
RCC2 -774
CORO2B 888
ARHGAP6 7000


GO:0009378 four-way junction helicase activity
set GO:0009378 four-way junction helicase activity
setSize 13
pANOVA 0.00511
s.dist -0.449
p.adjustANOVA 0.0748


Top enriched genes
Top 20 genes
GeneID Gene Rank
TWNK -7383
CHD7 -6915
CHD1 -6824
BLM -6673
FANCM -6408
RECQL5 -4524
RECQL -3887
WRN -2633
ERCC3 -1585
MCM9 -1478
MCM3 -1454
MCM8 2061
MCM5 2989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TWNK -7383
CHD7 -6915
CHD1 -6824
BLM -6673
FANCM -6408
RECQL5 -4524
RECQL -3887
WRN -2633
ERCC3 -1585
MCM9 -1478
MCM3 -1454
MCM8 2061
MCM5 2989


GO:0051603 proteolysis involved in protein catabolic process
set GO:0051603 proteolysis involved in protein catabolic process
setSize 23
pANOVA 0.000197
s.dist 0.448
p.adjustANOVA 0.00744


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTSC 6974
CTSV 6914
FAP 6841
PSMB5 6625
LGMN 6604
PSMB3 6527
CAPN2 6458
CTSK 6388
PSMB4 6324
PSMB1 6266
PSMB2 5941
CTSB 5506
PSMA2 5035
RSPRY1 4176
CTSO 3299
DNAJC3 1899
CTSH 1607
IDE 559
CASP8 -2942
RNF123 -3577

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSC 6974
CTSV 6914
FAP 6841
PSMB5 6625
LGMN 6604
PSMB3 6527
CAPN2 6458
CTSK 6388
PSMB4 6324
PSMB1 6266
PSMB2 5941
CTSB 5506
PSMA2 5035
RSPRY1 4176
CTSO 3299
DNAJC3 1899
CTSH 1607
IDE 559
CASP8 -2942
RNF123 -3577
CTSS -4424
CLPX -6273
ADAMTS7 -7140


GO:0031663 lipopolysaccharide-mediated signaling pathway
set GO:0031663 lipopolysaccharide-mediated signaling pathway
setSize 11
pANOVA 0.0107
s.dist 0.444
p.adjustANOVA 0.118


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTAFR 6512
RIPK2 6228
SCARB1 5715
MTDH 5713
IRAK2 4882
LY96 3231
LYN 2853
MAPK14 2189
PRKCE 517
TRAF6 -490
MAPK3 -4361

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTAFR 6512
RIPK2 6228
SCARB1 5715
MTDH 5713
IRAK2 4882
LY96 3231
LYN 2853
MAPK14 2189
PRKCE 517
TRAF6 -490
MAPK3 -4361


GO:0030863 cortical cytoskeleton
set GO:0030863 cortical cytoskeleton
setSize 10
pANOVA 0.0152
s.dist 0.443
p.adjustANOVA 0.147


Top enriched genes
Top 20 genes
GeneID Gene Rank
CAPZA2 5744
GYPC 5348
MPP1 4517
CTTN 3585
NOS2 3373
CAPZA1 3344
CAPZB 2154
DMTN 1278
EPB41 437
TPM4 138

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAPZA2 5744
GYPC 5348
MPP1 4517
CTTN 3585
NOS2 3373
CAPZA1 3344
CAPZB 2154
DMTN 1278
EPB41 437
TPM4 138


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.12.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] ggplot2_3.5.1               gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] UpSetR_1.4.0                beeswarm_0.4.0             
##  [9] kableExtra_1.4.0            eulerr_7.0.2               
## [11] mitch_1.19.2                MASS_7.3-61                
## [13] gplots_3.2.0                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         reshape2_1.4.4             
## [25] dplyr_1.1.4                 zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] tidyselect_1.2.1        viridisLite_0.4.2       farver_2.1.2           
##  [4] bitops_1.0-9            fastmap_1.2.0           promises_1.3.2         
##  [7] digest_0.6.37           mime_0.12               lifecycle_1.0.4        
## [10] polylabelr_0.3.0        magrittr_2.0.3          compiler_4.4.2         
## [13] rlang_1.1.4             sass_0.4.9              tools_4.4.2            
## [16] yaml_2.3.10             knitr_1.49              labeling_0.4.3         
## [19] S4Arrays_1.4.1          htmlwidgets_1.6.4       DelayedArray_0.30.1    
## [22] xml2_1.3.6              plyr_1.8.9              RColorBrewer_1.1-3     
## [25] abind_1.4-8             BiocParallel_1.38.0     KernSmooth_2.23-24     
## [28] withr_3.0.2             purrr_1.0.2             polyclip_1.10-7        
## [31] grid_4.4.2              caTools_1.18.3          xtable_1.8-4           
## [34] colorspace_2.1-1        scales_1.3.0            cli_3.6.3              
## [37] rmarkdown_2.29          crayon_1.5.3            generics_0.1.3         
## [40] rstudioapi_0.17.1       httr_1.4.7              cachem_1.1.0           
## [43] stringr_1.5.1           zlibbioc_1.50.0         parallel_4.4.2         
## [46] XVector_0.44.0          vctrs_0.6.5             Matrix_1.7-1           
## [49] jsonlite_1.8.9          systemfonts_1.1.0       locfit_1.5-9.10        
## [52] jquerylib_0.1.4         tidyr_1.3.1             glue_1.8.0             
## [55] ggstats_0.7.0           codetools_0.2-20        stringi_1.8.4          
## [58] gtable_0.3.6            later_1.4.1             UCSC.utils_1.0.0       
## [61] munsell_0.5.1           pillar_1.10.0           htmltools_0.5.8.1      
## [64] GenomeInfoDbData_1.2.12 R6_2.5.1                evaluate_1.0.1         
## [67] shiny_1.10.0            lattice_0.22-6          httpuv_1.6.15          
## [70] bslib_0.8.0             Rcpp_1.0.13-1           svglite_2.1.3          
## [73] gridExtra_2.3           SparseArray_1.4.8       xfun_0.49              
## [76] pkgconfig_2.0.3

END of report