Mitch Report

date generated: 2020-07-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##               rna       meth
## A2M     0.4967182 -0.3233384
## A4GALT  1.1055218 -0.5863825
## AAAS    2.1498692  0.6719368
## AACS   -0.8274404 -0.2305449
## AADAT   2.7771694 -1.3283099
## AAED1   1.1657765 -0.5888795

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	11707
duplicated_genes_present	0
num_profile_genes_in_sets	6727
num_profile_genes_not_in_sets	4980
profile_pearson_correl	0.0709
profile_spearman_correl	0.04238

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1142
num_genesets_included	1258

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 146

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.rna	s.meth	p.rna	p.meth
Establishment of Sister Chromatid Cohesion	10	4.25e-04	6.30e-03	0.724	0.7140	0.12000	9.25e-05	5.11e-01
Mitotic Telophase/Cytokinesis	10	5.54e-04	7.61e-03	0.715	0.6850	0.20400	1.76e-04	2.64e-01
Glucuronidation	11	4.90e-04	7.09e-03	0.693	0.5600	0.40800	1.29e-03	1.90e-02
Viral mRNA Translation	37	2.92e-11	9.17e-09	0.654	0.6270	-0.18300	3.97e-11	5.42e-02
Peptide chain elongation	37	1.12e-10	2.02e-08	0.636	0.6140	-0.16400	1.00e-10	8.51e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	10	2.48e-03	2.48e-02	0.619	-0.4600	0.41400	1.17e-02	2.34e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	10	2.48e-03	2.48e-02	0.619	-0.4600	0.41400	1.17e-02	2.34e-02
Selenocysteine synthesis	40	1.80e-10	2.84e-08	0.603	0.5670	-0.20600	5.45e-10	2.42e-02
Dissolution of Fibrin Clot	10	6.20e-03	5.31e-02	0.592	0.5200	0.28400	4.41e-03	1.20e-01
Activation of the pre-replicative complex	26	1.25e-06	4.91e-05	0.591	0.5910	0.01360	1.86e-07	9.04e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	44	2.07e-10	2.89e-08	0.580	0.5780	-0.04300	3.28e-11	6.22e-01
Eukaryotic Translation Termination	40	2.36e-09	2.12e-07	0.570	0.5520	-0.14000	1.50e-09	1.27e-01
Cyclin A/B1/B2 associated events during G2/M transition	19	1.17e-04	2.20e-03	0.558	0.5440	-0.12400	4.00e-05	3.50e-01
DNA strand elongation	26	9.02e-06	2.59e-04	0.544	0.5430	-0.03640	1.66e-06	7.48e-01
Eukaryotic Translation Elongation	40	1.78e-08	1.12e-06	0.540	0.5250	-0.12600	8.96e-09	1.68e-01
Heme degradation	10	1.07e-02	7.80e-02	0.540	0.2900	-0.45500	1.12e-01	1.28e-02
Recognition of DNA damage by PCNA-containing replication complex	21	8.30e-05	1.68e-03	0.540	0.5150	-0.16000	4.37e-05	2.04e-01
Mitophagy	19	3.22e-04	5.13e-03	0.532	-0.0205	-0.53100	8.77e-01	6.07e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	41	3.76e-08	1.97e-06	0.523	0.5120	-0.10500	1.37e-08	2.47e-01
Formation of a pool of free 40S subunits	46	4.55e-09	3.57e-07	0.522	0.4970	-0.15700	5.36e-09	6.62e-02
HSF1-dependent transactivation	26	2.72e-05	6.58e-04	0.518	-0.5180	0.01510	4.80e-06	8.94e-01
Condensation of Prophase Chromosomes	10	2.00e-02	1.22e-01	0.518	0.4860	0.17900	7.85e-03	3.26e-01
Processive synthesis on the lagging strand	12	8.26e-03	6.45e-02	0.516	0.5160	-0.00771	1.99e-03	9.63e-01
PINK1-PRKN Mediated Mitophagy	13	5.56e-03	4.82e-02	0.515	0.0101	-0.51500	9.50e-01	1.30e-03
PCNA-Dependent Long Patch Base Excision Repair	17	1.13e-03	1.36e-02	0.511	0.4970	-0.11600	3.85e-04	4.07e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	10	2.31e-02	1.34e-01	0.505	-0.4950	-0.10100	6.72e-03	5.79e-01
Termination of translesion DNA synthesis	23	1.68e-04	3.05e-03	0.497	0.4850	-0.10900	5.63e-05	3.65e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	14	6.48e-03	5.51e-02	0.497	0.4590	0.19200	2.98e-03	2.13e-01
Removal of the Flap Intermediate	11	1.64e-02	1.07e-01	0.496	0.4910	-0.06830	4.80e-03	6.95e-01
Selenoamino acid metabolism	53	1.85e-09	1.79e-07	0.495	0.4500	-0.20600	1.45e-08	9.40e-03
Nucleotide-like (purinergic) receptors	11	2.05e-02	1.24e-01	0.494	0.2540	0.42400	1.44e-01	1.49e-02
L13a-mediated translational silencing of Ceruloplasmin expression	50	8.78e-09	6.14e-07	0.493	0.4770	-0.12300	5.41e-09	1.34e-01
Polo-like kinase mediated events	13	9.45e-03	7.12e-02	0.491	0.4880	0.05930	2.33e-03	7.12e-01
G1/S-Specific Transcription	24	2.38e-04	4.10e-03	0.490	0.4250	0.24500	3.18e-04	3.75e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	1.75e-02	1.09e-01	0.489	0.4700	-0.13700	7.02e-03	4.30e-01
Translesion synthesis by REV1	11	1.86e-02	1.15e-01	0.485	0.4620	-0.14800	7.94e-03	3.97e-01
Translesion synthesis by POLK	12	1.34e-02	9.22e-02	0.483	0.4570	-0.15700	6.16e-03	3.46e-01
Synthesis of PIPs at the late endosome membrane	10	3.08e-02	1.59e-01	0.482	0.0071	0.48200	9.69e-01	8.34e-03
Attenuation phase	17	2.58e-03	2.53e-02	0.481	-0.4780	0.05460	6.47e-04	6.97e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	52	1.23e-08	8.12e-07	0.479	0.4670	-0.10600	5.59e-09	1.87e-01
G0 and Early G1	24	3.44e-04	5.41e-03	0.477	0.4530	0.14800	1.23e-04	2.09e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	29	3.74e-05	8.70e-04	0.476	-0.2000	0.43200	6.23e-02	5.59e-05
Gap-filling DNA repair synthesis and ligation in GG-NER	19	1.45e-03	1.65e-02	0.474	0.4610	-0.11000	4.99e-04	4.07e-01
SRP-dependent cotranslational protein targeting to membrane	55	6.93e-09	5.13e-07	0.473	0.4560	-0.12200	4.82e-09	1.17e-01
LGI-ADAM interactions	11	2.69e-02	1.47e-01	0.472	-0.4600	-0.10700	8.26e-03	5.38e-01
Cholesterol biosynthesis	20	1.51e-03	1.68e-02	0.472	-0.4390	-0.17300	6.74e-04	1.80e-01
Activation of ATR in response to replication stress	28	8.03e-05	1.68e-03	0.472	0.4700	-0.04160	1.66e-05	7.03e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	2.03e-02	1.24e-01	0.469	0.4600	0.08820	5.77e-03	5.97e-01
Lagging Strand Synthesis	17	3.45e-03	3.32e-02	0.467	0.4520	-0.11500	1.25e-03	4.10e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	19	1.98e-03	2.10e-02	0.466	0.4660	-0.02150	4.41e-04	8.71e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.rna	s.meth	p.rna	p.meth
Establishment of Sister Chromatid Cohesion	10	4.25e-04	6.30e-03	0.7240	7.14e-01	0.120000	9.25e-05	5.11e-01
Mitotic Telophase/Cytokinesis	10	5.54e-04	7.61e-03	0.7150	6.85e-01	0.204000	1.76e-04	2.64e-01
Glucuronidation	11	4.90e-04	7.09e-03	0.6930	5.60e-01	0.408000	1.29e-03	1.90e-02
Viral mRNA Translation	37	2.92e-11	9.17e-09	0.6540	6.27e-01	-0.183000	3.97e-11	5.42e-02
Peptide chain elongation	37	1.12e-10	2.02e-08	0.6360	6.14e-01	-0.164000	1.00e-10	8.51e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	10	2.48e-03	2.48e-02	0.6190	-4.60e-01	0.414000	1.17e-02	2.34e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	10	2.48e-03	2.48e-02	0.6190	-4.60e-01	0.414000	1.17e-02	2.34e-02
Selenocysteine synthesis	40	1.80e-10	2.84e-08	0.6030	5.67e-01	-0.206000	5.45e-10	2.42e-02
Dissolution of Fibrin Clot	10	6.20e-03	5.31e-02	0.5920	5.20e-01	0.284000	4.41e-03	1.20e-01
Activation of the pre-replicative complex	26	1.25e-06	4.91e-05	0.5910	5.91e-01	0.013600	1.86e-07	9.04e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	44	2.07e-10	2.89e-08	0.5800	5.78e-01	-0.043000	3.28e-11	6.22e-01
Eukaryotic Translation Termination	40	2.36e-09	2.12e-07	0.5700	5.52e-01	-0.140000	1.50e-09	1.27e-01
Cyclin A/B1/B2 associated events during G2/M transition	19	1.17e-04	2.20e-03	0.5580	5.44e-01	-0.124000	4.00e-05	3.50e-01
DNA strand elongation	26	9.02e-06	2.59e-04	0.5440	5.43e-01	-0.036400	1.66e-06	7.48e-01
Eukaryotic Translation Elongation	40	1.78e-08	1.12e-06	0.5400	5.25e-01	-0.126000	8.96e-09	1.68e-01
Heme degradation	10	1.07e-02	7.80e-02	0.5400	2.90e-01	-0.455000	1.12e-01	1.28e-02
Recognition of DNA damage by PCNA-containing replication complex	21	8.30e-05	1.68e-03	0.5400	5.15e-01	-0.160000	4.37e-05	2.04e-01
Mitophagy	19	3.22e-04	5.13e-03	0.5320	-2.05e-02	-0.531000	8.77e-01	6.07e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	41	3.76e-08	1.97e-06	0.5230	5.12e-01	-0.105000	1.37e-08	2.47e-01
Formation of a pool of free 40S subunits	46	4.55e-09	3.57e-07	0.5220	4.97e-01	-0.157000	5.36e-09	6.62e-02
HSF1-dependent transactivation	26	2.72e-05	6.58e-04	0.5180	-5.18e-01	0.015100	4.80e-06	8.94e-01
Condensation of Prophase Chromosomes	10	2.00e-02	1.22e-01	0.5180	4.86e-01	0.179000	7.85e-03	3.26e-01
Processive synthesis on the lagging strand	12	8.26e-03	6.45e-02	0.5160	5.16e-01	-0.007710	1.99e-03	9.63e-01
PINK1-PRKN Mediated Mitophagy	13	5.56e-03	4.82e-02	0.5150	1.01e-02	-0.515000	9.50e-01	1.30e-03
PCNA-Dependent Long Patch Base Excision Repair	17	1.13e-03	1.36e-02	0.5110	4.97e-01	-0.116000	3.85e-04	4.07e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	10	2.31e-02	1.34e-01	0.5050	-4.95e-01	-0.101000	6.72e-03	5.79e-01
Termination of translesion DNA synthesis	23	1.68e-04	3.05e-03	0.4970	4.85e-01	-0.109000	5.63e-05	3.65e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	14	6.48e-03	5.51e-02	0.4970	4.59e-01	0.192000	2.98e-03	2.13e-01
Removal of the Flap Intermediate	11	1.64e-02	1.07e-01	0.4960	4.91e-01	-0.068300	4.80e-03	6.95e-01
Selenoamino acid metabolism	53	1.85e-09	1.79e-07	0.4950	4.50e-01	-0.206000	1.45e-08	9.40e-03
Nucleotide-like (purinergic) receptors	11	2.05e-02	1.24e-01	0.4940	2.54e-01	0.424000	1.44e-01	1.49e-02
L13a-mediated translational silencing of Ceruloplasmin expression	50	8.78e-09	6.14e-07	0.4930	4.77e-01	-0.123000	5.41e-09	1.34e-01
Polo-like kinase mediated events	13	9.45e-03	7.12e-02	0.4910	4.88e-01	0.059300	2.33e-03	7.12e-01
G1/S-Specific Transcription	24	2.38e-04	4.10e-03	0.4900	4.25e-01	0.245000	3.18e-04	3.75e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	1.75e-02	1.09e-01	0.4890	4.70e-01	-0.137000	7.02e-03	4.30e-01
Translesion synthesis by REV1	11	1.86e-02	1.15e-01	0.4850	4.62e-01	-0.148000	7.94e-03	3.97e-01
Translesion synthesis by POLK	12	1.34e-02	9.22e-02	0.4830	4.57e-01	-0.157000	6.16e-03	3.46e-01
Synthesis of PIPs at the late endosome membrane	10	3.08e-02	1.59e-01	0.4820	7.10e-03	0.482000	9.69e-01	8.34e-03
Attenuation phase	17	2.58e-03	2.53e-02	0.4810	-4.78e-01	0.054600	6.47e-04	6.97e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	52	1.23e-08	8.12e-07	0.4790	4.67e-01	-0.106000	5.59e-09	1.87e-01
G0 and Early G1	24	3.44e-04	5.41e-03	0.4770	4.53e-01	0.148000	1.23e-04	2.09e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	29	3.74e-05	8.70e-04	0.4760	-2.00e-01	0.432000	6.23e-02	5.59e-05
Gap-filling DNA repair synthesis and ligation in GG-NER	19	1.45e-03	1.65e-02	0.4740	4.61e-01	-0.110000	4.99e-04	4.07e-01
SRP-dependent cotranslational protein targeting to membrane	55	6.93e-09	5.13e-07	0.4730	4.56e-01	-0.122000	4.82e-09	1.17e-01
LGI-ADAM interactions	11	2.69e-02	1.47e-01	0.4720	-4.60e-01	-0.107000	8.26e-03	5.38e-01
Cholesterol biosynthesis	20	1.51e-03	1.68e-02	0.4720	-4.39e-01	-0.173000	6.74e-04	1.80e-01
Activation of ATR in response to replication stress	28	8.03e-05	1.68e-03	0.4720	4.70e-01	-0.041600	1.66e-05	7.03e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	2.03e-02	1.24e-01	0.4690	4.60e-01	0.088200	5.77e-03	5.97e-01
Lagging Strand Synthesis	17	3.45e-03	3.32e-02	0.4670	4.52e-01	-0.115000	1.25e-03	4.10e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	19	1.98e-03	2.10e-02	0.4660	4.66e-01	-0.021500	4.41e-04	8.71e-01
Organic cation/anion/zwitterion transport	10	4.41e-02	1.99e-01	0.4640	2.17e-01	0.410000	2.35e-01	2.47e-02
CLEC7A (Dectin-1) induces NFAT activation	10	4.35e-02	1.98e-01	0.4630	1.38e-01	0.442000	4.51e-01	1.56e-02
O-glycosylation of TSR domain-containing proteins	30	4.89e-05	1.10e-03	0.4620	-2.06e-01	0.413000	5.10e-02	8.91e-05
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	26	3.14e-04	5.07e-03	0.4510	4.41e-01	-0.095400	1.01e-04	4.00e-01
Translesion synthesis by POLI	12	2.43e-02	1.38e-01	0.4510	4.42e-01	-0.088200	8.03e-03	5.97e-01
Transport of vitamins, nucleosides, and related molecules	26	4.51e-04	6.59e-03	0.4460	-3.95e-02	-0.444000	7.27e-01	8.81e-05
Collagen chain trimerization	32	6.08e-05	1.32e-03	0.4420	-3.89e-01	0.209000	1.39e-04	4.05e-02
Cap-dependent Translation Initiation	58	3.34e-08	1.91e-06	0.4410	4.28e-01	-0.107000	1.80e-08	1.58e-01
Eukaryotic Translation Initiation	58	3.34e-08	1.91e-06	0.4410	4.28e-01	-0.107000	1.80e-08	1.58e-01
Glucagon-type ligand receptors	13	2.82e-02	1.51e-01	0.4370	-3.02e-01	-0.316000	5.93e-02	4.88e-02
Interferon alpha/beta signaling	41	9.38e-06	2.62e-04	0.4350	4.34e-01	0.029100	1.51e-06	7.47e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	58	1.02e-07	4.60e-06	0.4290	4.29e-01	-0.025500	1.66e-08	7.37e-01
Nonsense-Mediated Decay (NMD)	58	1.02e-07	4.60e-06	0.4290	4.29e-01	-0.025500	1.66e-08	7.37e-01
Interleukin-12 signaling	30	2.47e-04	4.20e-03	0.4280	4.26e-01	-0.042500	5.46e-05	6.87e-01
E2F mediated regulation of DNA replication	18	8.09e-03	6.44e-02	0.4280	4.07e-01	0.130000	2.78e-03	3.39e-01
Phosphorylation of CD3 and TCR zeta chains	10	7.17e-02	2.73e-01	0.4250	4.01e-01	0.139000	2.81e-02	4.47e-01
CRMPs in Sema3A signaling	14	2.31e-02	1.34e-01	0.4210	-5.39e-02	0.418000	7.27e-01	6.80e-03
Lysine catabolism	10	6.33e-02	2.48e-01	0.4210	3.68e-01	-0.205000	4.40e-02	2.62e-01
Formation of the ternary complex, and subsequently, the 43S complex	26	9.41e-04	1.18e-02	0.4210	4.18e-01	-0.050700	2.30e-04	6.55e-01
Removal of the Flap Intermediate from the C-strand	12	3.80e-02	1.83e-01	0.4200	3.96e-01	-0.141000	1.76e-02	3.97e-01
Leading Strand Synthesis	13	3.07e-02	1.59e-01	0.4190	4.10e-01	-0.088400	1.06e-02	5.81e-01
Polymerase switching	13	3.07e-02	1.59e-01	0.4190	4.10e-01	-0.088400	1.06e-02	5.81e-01
DNA Damage Bypass	34	1.47e-04	2.71e-03	0.4140	4.12e-01	-0.043900	3.24e-05	6.58e-01
Surfactant metabolism	12	5.18e-02	2.16e-01	0.4120	-1.53e-01	-0.382000	3.58e-01	2.20e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	30	5.02e-04	7.11e-03	0.4090	4.06e-01	-0.050200	1.20e-04	6.35e-01
KSRP (KHSRP) binds and destabilizes mRNA	14	2.63e-02	1.46e-01	0.4080	2.64e-01	-0.311000	8.78e-02	4.40e-02
Transcription of E2F targets under negative control by DREAM complex	17	1.63e-02	1.07e-01	0.4070	3.90e-01	0.115000	5.39e-03	4.13e-01
Ribosomal scanning and start codon recognition	30	5.57e-04	7.61e-03	0.4060	4.04e-01	-0.042700	1.28e-04	6.86e-01
Synthesis of PC	21	5.70e-03	4.91e-02	0.4060	-4.05e-01	-0.030000	1.31e-03	8.12e-01
Retrograde neurotrophin signalling	14	2.72e-02	1.48e-01	0.4060	-2.65e-01	0.307000	8.64e-02	4.65e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	5.44e-02	2.24e-01	0.4040	4.01e-01	0.050600	1.62e-02	7.62e-01
Interleukin-12 family signaling	36	1.70e-04	3.05e-03	0.3990	3.94e-01	-0.059800	4.30e-05	5.35e-01
Orc1 removal from chromatin	54	2.32e-06	8.36e-05	0.3960	3.76e-01	-0.124000	1.83e-06	1.15e-01
Signaling by BMP	20	9.27e-03	7.07e-02	0.3930	-3.72e-02	0.392000	7.74e-01	2.43e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	28	1.47e-03	1.65e-02	0.3930	3.92e-01	-0.025100	3.28e-04	8.18e-01
ERBB2 Activates PTK6 Signaling	10	9.19e-02	3.21e-01	0.3910	-3.18e-01	0.227000	8.12e-02	2.14e-01
Translation initiation complex formation	29	1.25e-03	1.49e-02	0.3900	3.88e-01	-0.042000	3.01e-04	6.95e-01
Early Phase of HIV Life Cycle	10	1.13e-01	3.57e-01	0.3880	3.37e-01	0.194000	6.54e-02	2.89e-01
Incretin synthesis, secretion, and inactivation	10	9.67e-02	3.32e-01	0.3880	-1.90e-01	0.338000	2.99e-01	6.43e-02
Signaling by FGFR3 fusions in cancer	10	9.83e-02	3.36e-01	0.3860	3.41e-01	-0.182000	6.20e-02	3.20e-01
Processive synthesis on the C-strand of the telomere	14	4.27e-02	1.96e-01	0.3850	3.80e-01	-0.058300	1.37e-02	7.06e-01
Pre-NOTCH Processing in Golgi	14	4.09e-02	1.91e-01	0.3850	-3.59e-01	0.137000	2.00e-02	3.74e-01
Mitotic G1 phase and G1/S transition	120	2.79e-12	1.17e-09	0.3840	3.83e-01	-0.034000	4.75e-13	5.21e-01
G1/S Transition	106	5.42e-11	1.36e-08	0.3840	3.80e-01	-0.058500	1.51e-11	2.99e-01
DNA Replication Pre-Initiation	66	3.85e-07	1.62e-05	0.3840	3.76e-01	-0.076300	1.31e-07	2.84e-01
ERBB2 Regulates Cell Motility	12	6.39e-02	2.48e-01	0.3830	-2.96e-01	0.243000	7.62e-02	1.45e-01
Transport of bile salts and organic acids, metal ions and amine compounds	45	8.19e-05	1.68e-03	0.3810	3.13e-01	0.218000	2.84e-04	1.15e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	1.09e-01	3.53e-01	0.3800	-1.01e-01	0.367000	5.82e-01	4.47e-02
Carnitine metabolism	11	1.01e-01	3.37e-01	0.3790	-3.36e-01	-0.177000	5.40e-02	3.10e-01
CD28 dependent Vav1 pathway	12	8.22e-02	2.95e-01	0.3760	3.67e-01	0.082400	2.79e-02	6.21e-01
Activation of AMPK downstream of NMDARs	10	1.18e-01	3.66e-01	0.3750	-3.72e-01	0.045500	4.15e-02	8.03e-01
Mismatch Repair	13	6.97e-02	2.67e-01	0.3730	3.61e-01	0.094900	2.42e-02	5.53e-01
Glycogen synthesis	10	1.26e-01	3.82e-01	0.3730	-3.72e-01	-0.026900	4.18e-02	8.83e-01
Polymerase switching on the C-strand of the telomere	21	1.18e-02	8.34e-02	0.3730	3.65e-01	-0.072400	3.76e-03	5.66e-01
S Phase	135	7.62e-13	4.79e-10	0.3700	3.64e-01	-0.067900	3.31e-13	1.74e-01
NCAM1 interactions	27	3.87e-03	3.66e-02	0.3700	-3.69e-01	0.019100	9.06e-04	8.63e-01
Initial triggering of complement	18	2.27e-02	1.34e-01	0.3670	2.67e-01	-0.252000	5.03e-02	6.45e-02
Receptor-type tyrosine-protein phosphatases	13	7.36e-02	2.74e-01	0.3640	-3.29e-02	0.363000	8.37e-01	2.36e-02
Synthesis of DNA	97	3.25e-09	2.73e-07	0.3640	3.53e-01	-0.089500	2.05e-09	1.28e-01
DNA Replication	104	1.08e-09	1.13e-07	0.3620	3.53e-01	-0.076800	5.01e-10	1.77e-01
Post-chaperonin tubulin folding pathway	17	4.13e-02	1.92e-01	0.3600	-1.72e-01	-0.316000	2.21e-01	2.39e-02
Assembly of collagen fibrils and other multimeric structures	43	2.70e-04	4.42e-03	0.3570	-3.56e-01	0.013600	5.34e-05	8.77e-01
Adherens junctions interactions	13	7.77e-02	2.84e-01	0.3560	-1.53e-01	0.321000	3.39e-01	4.48e-02
Synthesis of pyrophosphates in the cytosol	10	1.57e-01	4.31e-01	0.3520	-3.37e-02	-0.351000	8.54e-01	5.48e-02
Metal ion SLC transporters	17	4.56e-02	2.03e-01	0.3500	3.47e-01	0.043100	1.33e-02	7.58e-01
Nicotinamide salvaging	13	8.33e-02	2.97e-01	0.3500	2.19e-01	-0.273000	1.71e-01	8.89e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	13	8.37e-02	2.97e-01	0.3500	-2.86e-01	0.202000	7.47e-02	2.08e-01
Telomere C-strand (Lagging Strand) Synthesis	27	6.95e-03	5.83e-02	0.3480	3.45e-01	-0.048500	1.93e-03	6.63e-01
Regulation of IFNG signaling	12	1.26e-01	3.82e-01	0.3450	1.69e-01	0.301000	3.11e-01	7.08e-02
Influenza Viral RNA Transcription and Replication	69	3.57e-06	1.21e-04	0.3450	3.35e-01	-0.083400	1.52e-06	2.31e-01
Translesion Synthesis by POLH	11	1.30e-01	3.90e-01	0.3450	2.86e-01	-0.193000	1.01e-01	2.67e-01
Collagen biosynthesis and modifying enzymes	50	1.00e-04	1.94e-03	0.3450	-3.07e-01	0.158000	1.79e-04	5.37e-02
Diseases of carbohydrate metabolism	22	2.26e-02	1.34e-01	0.3450	-3.08e-01	-0.154000	1.23e-02	2.11e-01
Effects of PIP2 hydrolysis	22	2.15e-02	1.28e-01	0.3440	-3.36e-01	-0.073200	6.34e-03	5.52e-01
Regulation of expression of SLITs and ROBOs	95	4.02e-08	2.02e-06	0.3440	3.38e-01	-0.061600	1.24e-08	3.01e-01
Phase II - Conjugation of compounds	66	9.05e-06	2.59e-04	0.3440	3.43e-01	0.019500	1.44e-06	7.84e-01
Zinc transporters	10	1.75e-01	4.63e-01	0.3430	3.38e-01	0.055500	6.40e-02	7.61e-01
Cyclin D associated events in G1	37	1.59e-03	1.74e-02	0.3420	3.41e-01	0.032600	3.38e-04	7.31e-01
G1 Phase	37	1.59e-03	1.74e-02	0.3420	3.41e-01	0.032600	3.38e-04	7.31e-01
Elevation of cytosolic Ca2+ levels	10	1.76e-01	4.63e-01	0.3420	-3.39e-01	-0.048900	6.37e-02	7.89e-01
Assembly of the pre-replicative complex	52	9.63e-05	1.89e-03	0.3410	3.30e-01	-0.086200	3.88e-05	2.83e-01
Regulation of FZD by ubiquitination	10	1.88e-01	4.77e-01	0.3410	-2.69e-01	-0.209000	1.41e-01	2.52e-01
DCC mediated attractive signaling	13	1.13e-01	3.57e-01	0.3400	1.44e-01	0.308000	3.69e-01	5.44e-02
Caspase-mediated cleavage of cytoskeletal proteins	11	1.39e-01	4.04e-01	0.3390	-1.98e-01	0.275000	2.56e-01	1.14e-01
Regulation of pyruvate dehydrogenase (PDH) complex	12	1.30e-01	3.90e-01	0.3390	-4.43e-02	-0.336000	7.91e-01	4.41e-02
Cleavage of the damaged pyrimidine	13	1.01e-01	3.37e-01	0.3380	1.38e-01	-0.308000	3.88e-01	5.46e-02
Depyrimidination	13	1.01e-01	3.37e-01	0.3380	1.38e-01	-0.308000	3.88e-01	5.46e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	13	1.01e-01	3.37e-01	0.3380	1.38e-01	-0.308000	3.88e-01	5.46e-02
Creation of C4 and C2 activators	11	1.50e-01	4.25e-01	0.3340	1.30e-01	-0.307000	4.55e-01	7.78e-02
Formation of Fibrin Clot (Clotting Cascade)	15	8.49e-02	3.00e-01	0.3340	3.28e-01	0.063700	2.81e-02	6.69e-01
SCF(Skp2)-mediated degradation of p27/p21	46	3.67e-04	5.70e-03	0.3320	2.78e-01	-0.182000	1.11e-03	3.27e-02
Activation of Matrix Metalloproteinases	17	6.09e-02	2.43e-01	0.3320	-3.31e-01	-0.022400	1.80e-02	8.73e-01
Signaling by Activin	10	1.90e-01	4.80e-01	0.3310	-3.29e-01	0.038700	7.21e-02	8.32e-01
Glutathione synthesis and recycling	11	1.53e-01	4.28e-01	0.3310	1.77e-01	-0.279000	3.08e-01	1.09e-01
Heme biosynthesis	11	1.81e-01	4.67e-01	0.3280	-2.75e-01	-0.178000	1.14e-01	3.06e-01
Regulation of IFNA signaling	12	1.55e-01	4.28e-01	0.3270	2.90e-01	0.152000	8.20e-02	3.63e-01
Influenza Infection	82	1.69e-06	6.44e-05	0.3260	3.18e-01	-0.074100	6.69e-07	2.47e-01
ATF6 (ATF6-alpha) activates chaperones	10	2.13e-01	5.07e-01	0.3260	3.03e-01	0.118000	9.66e-02	5.17e-01
G2/M Checkpoints	107	3.66e-08	1.97e-06	0.3250	3.18e-01	-0.067000	1.41e-08	2.32e-01
Negative regulation of NOTCH4 signaling	42	1.05e-03	1.31e-02	0.3240	2.80e-01	-0.163000	1.71e-03	6.70e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	1.62e-01	4.40e-01	0.3230	2.89e-01	0.145000	8.31e-02	3.83e-01
Regulation of localization of FOXO transcription factors	12	1.49e-01	4.25e-01	0.3230	4.44e-02	-0.320000	7.90e-01	5.49e-02
Meiotic synapsis	24	2.18e-02	1.29e-01	0.3210	2.99e-01	-0.118000	1.13e-02	3.17e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	10	2.22e-01	5.21e-01	0.3210	3.02e-01	0.110000	9.87e-02	5.47e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	77	6.33e-06	1.94e-04	0.3210	3.17e-01	-0.048000	1.56e-06	4.67e-01
Interleukin-35 Signalling	10	2.14e-01	5.09e-01	0.3200	3.20e-01	-0.005490	7.96e-02	9.76e-01
mRNA decay by 3' to 5' exoribonuclease	11	1.73e-01	4.61e-01	0.3200	1.78e-01	-0.266000	3.08e-01	1.27e-01
Metabolism of Angiotensinogen to Angiotensins	12	1.54e-01	4.28e-01	0.3180	-2.97e-01	0.112000	7.47e-02	5.00e-01
Purine salvage	10	2.16e-01	5.10e-01	0.3160	3.04e-01	-0.088000	9.64e-02	6.30e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	1.54e-01	4.28e-01	0.3160	-2.50e-01	0.193000	1.33e-01	2.48e-01
Defective EXT2 causes exostoses 2	12	1.54e-01	4.28e-01	0.3160	-2.50e-01	0.193000	1.33e-01	2.48e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	15	1.15e-01	3.60e-01	0.3160	2.78e-01	0.150000	6.26e-02	3.15e-01
Selective autophagy	46	1.39e-03	1.63e-02	0.3160	-1.85e-01	-0.256000	3.05e-02	2.69e-03
ATF4 activates genes in response to endoplasmic reticulum stress	21	4.73e-02	2.03e-01	0.3150	3.00e-01	0.097000	1.74e-02	4.42e-01
Activated NOTCH1 Transmits Signal to the Nucleus	22	3.48e-02	1.71e-01	0.3140	-2.92e-01	0.116000	1.77e-02	3.46e-01
RHO GTPases activate IQGAPs	10	2.42e-01	5.47e-01	0.3140	2.24e-01	0.221000	2.21e-01	2.27e-01
Switching of origins to a post-replicative state	72	2.12e-05	5.45e-04	0.3120	2.96e-01	-0.100000	1.46e-05	1.43e-01
G beta:gamma signalling through BTK	10	2.41e-01	5.45e-01	0.3120	-9.90e-02	-0.296000	5.88e-01	1.05e-01
Peptide hormone metabolism	50	5.22e-04	7.30e-03	0.3110	-1.91e-01	0.246000	1.97e-02	2.62e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	11	1.96e-01	4.88e-01	0.3110	-3.00e-01	0.081800	8.54e-02	6.39e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	11	1.96e-01	4.88e-01	0.3110	-3.00e-01	0.081800	8.54e-02	6.39e-01
CDT1 association with the CDC6:ORC:origin complex	44	1.45e-03	1.65e-02	0.3100	2.85e-01	-0.122000	1.07e-03	1.61e-01
IRE1alpha activates chaperones	44	2.37e-03	2.42e-02	0.3090	-2.08e-01	-0.229000	1.71e-02	8.57e-03
Insulin receptor recycling	17	9.57e-02	3.30e-01	0.3070	-8.79e-02	-0.294000	5.31e-01	3.59e-02
Transcriptional Regulation by E2F6	30	1.45e-02	9.63e-02	0.3060	3.06e-01	-0.017100	3.77e-03	8.71e-01
Processing of DNA double-strand break ends	50	7.93e-04	1.07e-02	0.3060	2.96e-01	-0.076300	2.96e-04	3.51e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	5.47e-02	2.24e-01	0.3050	-3.03e-01	-0.034100	1.62e-02	7.87e-01
G beta:gamma signalling through PI3Kgamma	16	1.10e-01	3.53e-01	0.3050	-3.14e-02	-0.303000	8.28e-01	3.59e-02
Cyclin E associated events during G1/S transition	67	7.49e-05	1.60e-03	0.3030	2.73e-01	-0.131000	1.13e-04	6.34e-02
Telomere C-strand synthesis initiation	10	2.56e-01	5.67e-01	0.3030	3.01e-01	0.034700	9.99e-02	8.49e-01
HDR through Homologous Recombination (HRR)	50	1.13e-03	1.36e-02	0.3020	3.01e-01	0.017300	2.30e-04	8.32e-01
Growth hormone receptor signaling	17	9.77e-02	3.35e-01	0.3000	-4.41e-02	0.297000	7.53e-01	3.41e-02
Collagen formation	68	8.58e-05	1.71e-03	0.2990	-2.80e-01	0.105000	6.50e-05	1.35e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	1.44e-01	4.18e-01	0.2990	2.67e-01	0.133000	7.32e-02	3.72e-01
Pyruvate metabolism	23	4.62e-02	2.03e-01	0.2990	6.47e-04	-0.299000	9.96e-01	1.32e-02
Extension of Telomeres	40	4.66e-03	4.28e-02	0.2980	2.97e-01	-0.024800	1.15e-03	7.87e-01
Insulin processing	19	7.22e-02	2.74e-01	0.2980	-1.53e-01	0.256000	2.49e-01	5.35e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	38	5.19e-03	4.57e-02	0.2980	2.43e-01	-0.173000	9.56e-03	6.59e-02
G beta:gamma signalling through PLC beta	12	2.18e-01	5.14e-01	0.2970	-2.08e-01	-0.213000	2.13e-01	2.03e-01
Synthesis of IP3 and IP4 in the cytosol	20	6.96e-02	2.67e-01	0.2970	-2.95e-01	0.031000	2.24e-02	8.10e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	48	1.66e-03	1.80e-02	0.2960	2.90e-01	-0.061500	5.26e-04	4.61e-01
Apoptotic factor-mediated response	12	2.22e-01	5.21e-01	0.2950	-1.66e-01	-0.244000	3.20e-01	1.44e-01
PERK regulates gene expression	24	4.92e-02	2.10e-01	0.2940	2.65e-01	0.129000	2.49e-02	2.75e-01
Cytosolic sulfonation of small molecules	13	1.98e-01	4.89e-01	0.2940	2.34e-01	0.179000	1.45e-01	2.65e-01
Vif-mediated degradation of APOBEC3G	39	5.31e-03	4.64e-02	0.2940	2.41e-01	-0.167000	9.17e-03	7.06e-02
DARPP-32 events	21	7.39e-02	2.74e-01	0.2940	1.78e-01	0.234000	1.59e-01	6.39e-02
GRB2 events in EGFR signaling	10	2.90e-01	6.03e-01	0.2940	-1.91e-01	-0.223000	2.96e-01	2.22e-01
Dual Incision in GG-NER	33	1.19e-02	8.34e-02	0.2930	2.30e-01	-0.183000	2.24e-02	6.98e-02
RUNX3 regulates NOTCH signaling	13	1.78e-01	4.63e-01	0.2930	-1.01e-01	0.275000	5.29e-01	8.58e-02
Cyclin A:Cdk2-associated events at S phase entry	69	1.06e-04	2.02e-03	0.2930	2.66e-01	-0.123000	1.33e-04	7.83e-02
Diseases associated with O-glycosylation of proteins	41	4.21e-03	3.92e-02	0.2930	-1.59e-01	0.246000	7.90e-02	6.41e-03
RNA Polymerase III Chain Elongation	13	1.86e-01	4.74e-01	0.2920	4.49e-02	-0.288000	7.79e-01	7.19e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	18	9.32e-02	3.24e-01	0.2910	-2.37e-01	0.169000	8.22e-02	2.15e-01
Signal transduction by L1	19	8.45e-02	3.00e-01	0.2900	1.15e-01	-0.266000	3.86e-01	4.47e-02
Cross-presentation of soluble exogenous antigens (endosomes)	41	4.81e-03	4.36e-02	0.2890	2.50e-01	-0.146000	5.62e-03	1.07e-01
Telomere Maintenance	49	2.13e-03	2.21e-02	0.2890	2.88e-01	-0.024300	5.02e-04	7.69e-01
p75NTR signals via NF-kB	10	2.72e-01	5.89e-01	0.2880	-2.29e-01	0.175000	2.10e-01	3.37e-01
Metabolism of porphyrins	20	8.75e-02	3.07e-01	0.2870	-4.93e-02	-0.283000	7.03e-01	2.86e-02
Chromosome Maintenance	63	4.18e-04	6.30e-03	0.2870	2.86e-01	-0.013600	8.54e-05	8.52e-01
Resolution of Sister Chromatid Cohesion	83	4.26e-05	9.75e-04	0.2860	2.85e-01	0.023600	7.37e-06	7.11e-01
Transferrin endocytosis and recycling	22	7.62e-02	2.80e-01	0.2850	-2.07e-01	-0.197000	9.30e-02	1.11e-01
EPHB-mediated forward signaling	30	2.96e-02	1.55e-01	0.2850	2.46e-01	0.145000	1.99e-02	1.71e-01
Degradation of AXIN	42	4.93e-03	4.42e-02	0.2850	2.33e-01	-0.164000	9.12e-03	6.54e-02
XBP1(S) activates chaperone genes	42	7.61e-03	6.25e-02	0.2850	-2.04e-01	-0.199000	2.25e-02	2.59e-02
Homology Directed Repair	81	5.68e-05	1.25e-03	0.2830	2.82e-01	-0.026700	1.18e-05	6.78e-01
Interleukin-7 signaling	16	1.36e-01	3.98e-01	0.2830	-1.50e-01	0.240000	2.98e-01	9.68e-02
Collagen degradation	24	5.06e-02	2.14e-01	0.2820	-2.36e-01	0.155000	4.55e-02	1.88e-01
Deposition of new CENPA-containing nucleosomes at the centromere	16	1.50e-01	4.25e-01	0.2820	2.81e-01	0.028400	5.20e-02	8.44e-01
Nucleosome assembly	16	1.50e-01	4.25e-01	0.2820	2.81e-01	0.028400	5.20e-02	8.44e-01
Degradation of cysteine and homocysteine	10	2.98e-01	6.12e-01	0.2820	4.73e-02	-0.278000	7.96e-01	1.28e-01
Triglyceride catabolism	14	1.86e-01	4.74e-01	0.2820	-2.47e-02	0.281000	8.73e-01	6.89e-02
Diseases associated with N-glycosylation of proteins	16	1.37e-01	4.01e-01	0.2820	-2.16e-01	0.181000	1.34e-01	2.11e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.26e-01	5.26e-01	0.2810	-2.44e-01	-0.140000	1.28e-01	3.83e-01
Metabolism of polyamines	49	2.47e-03	2.48e-02	0.2810	2.44e-01	-0.139000	3.11e-03	9.32e-02
Inhibition of DNA recombination at telomere	13	2.06e-01	4.99e-01	0.2810	2.62e-01	-0.101000	1.02e-01	5.28e-01
IL-6-type cytokine receptor ligand interactions	11	2.89e-01	6.03e-01	0.2800	2.29e-01	0.161000	1.88e-01	3.57e-01
FCGR activation	15	1.59e-01	4.35e-01	0.2800	2.17e-01	-0.176000	1.45e-01	2.37e-01
Free fatty acids regulate insulin secretion	10	3.07e-01	6.23e-01	0.2790	-2.77e-01	0.035900	1.30e-01	8.44e-01
NRAGE signals death through JNK	54	1.47e-03	1.65e-02	0.2790	-2.38e-01	0.145000	2.48e-03	6.56e-02
Sema4D induced cell migration and growth-cone collapse	19	1.16e-01	3.60e-01	0.2780	-2.71e-01	-0.062600	4.13e-02	6.37e-01
Signaling by Retinoic Acid	31	2.59e-02	1.45e-01	0.2750	1.40e-01	-0.237000	1.78e-01	2.24e-02
Metalloprotease DUBs	16	1.81e-01	4.66e-01	0.2730	2.11e-01	0.173000	1.45e-01	2.30e-01
Regulation of Complement cascade	31	2.75e-02	1.49e-01	0.2730	2.22e-01	-0.158000	3.25e-02	1.27e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	61	9.24e-04	1.18e-02	0.2730	2.50e-01	-0.108000	7.32e-04	1.45e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	61	9.24e-04	1.18e-02	0.2730	2.50e-01	-0.108000	7.32e-04	1.45e-01
Glycogen metabolism	21	9.56e-02	3.30e-01	0.2720	-2.72e-01	0.018100	3.12e-02	8.86e-01
Postmitotic nuclear pore complex (NPC) reformation	20	9.94e-02	3.37e-01	0.2720	1.51e-01	-0.227000	2.44e-01	7.93e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	43	7.06e-03	5.88e-02	0.2720	2.27e-01	-0.150000	9.96e-03	9.00e-02
G2/M DNA damage checkpoint	51	3.28e-03	3.17e-02	0.2710	2.66e-01	-0.055100	1.03e-03	4.96e-01
HSF1 activation	19	1.26e-01	3.82e-01	0.2700	-2.70e-01	-0.020700	4.20e-02	8.76e-01
Synthesis of PIPs at the early endosome membrane	15	1.90e-01	4.80e-01	0.2700	-3.37e-02	0.268000	8.21e-01	7.23e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	49	4.38e-03	4.05e-02	0.2680	2.43e-01	-0.113000	3.28e-03	1.73e-01
Vpu mediated degradation of CD4	40	1.19e-02	8.34e-02	0.2670	2.35e-01	-0.128000	1.03e-02	1.61e-01
Base Excision Repair	37	1.69e-02	1.07e-01	0.2670	2.45e-01	-0.106000	9.82e-03	2.67e-01
Other semaphorin interactions	18	1.48e-01	4.25e-01	0.2670	1.97e-02	0.266000	8.85e-01	5.06e-02
Binding and Uptake of Ligands by Scavenger Receptors	28	5.18e-02	2.16e-01	0.2670	-2.65e-01	-0.030900	1.52e-02	7.77e-01
Diseases associated with glycosylation precursor biosynthesis	16	1.74e-01	4.61e-01	0.2670	-2.55e-01	0.079700	7.80e-02	5.81e-01
Formation of Incision Complex in GG-NER	32	2.88e-02	1.53e-01	0.2670	1.55e-01	-0.217000	1.29e-01	3.40e-02
ROS and RNS production in phagocytes	26	6.13e-02	2.43e-01	0.2670	2.46e-02	-0.265000	8.28e-01	1.92e-02
rRNA processing in the nucleus and cytosol	117	2.66e-06	9.28e-05	0.2660	2.27e-01	-0.140000	2.40e-05	8.90e-03
Processing of Intronless Pre-mRNAs	12	2.81e-01	5.95e-01	0.2660	2.65e-01	0.022800	1.12e-01	8.91e-01
HDMs demethylate histones	19	1.24e-01	3.78e-01	0.2650	-1.94e-01	0.181000	1.44e-01	1.72e-01
Presynaptic phase of homologous DNA pairing and strand exchange	32	3.31e-02	1.67e-01	0.2650	2.63e-01	-0.035900	1.02e-02	7.26e-01
Cell Cycle Checkpoints	204	5.42e-10	6.82e-08	0.2640	2.60e-01	-0.044100	1.66e-10	2.79e-01
Activation of RAC1	12	2.98e-01	6.12e-01	0.2640	2.31e-01	0.127000	1.65e-01	4.47e-01
Assembly of active LPL and LIPC lipase complexes	11	3.15e-01	6.32e-01	0.2640	-2.64e-01	0.015100	1.30e-01	9.31e-01
Formation of the Early Elongation Complex	25	8.08e-02	2.91e-01	0.2640	-1.16e-01	-0.237000	3.17e-01	4.05e-02
Formation of the HIV-1 Early Elongation Complex	25	8.08e-02	2.91e-01	0.2640	-1.16e-01	-0.237000	3.17e-01	4.05e-02
Signaling by PDGFRA extracellular domain mutants	12	2.73e-01	5.89e-01	0.2630	2.11e-01	-0.157000	2.05e-01	3.46e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	2.73e-01	5.89e-01	0.2630	2.11e-01	-0.157000	2.05e-01	3.46e-01
Interferon gamma signaling	61	1.74e-03	1.86e-02	0.2630	2.62e-01	-0.018900	3.97e-04	7.99e-01
Signaling by FGFR4 in disease	10	3.39e-01	6.61e-01	0.2630	1.54e-01	-0.213000	3.98e-01	2.43e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	46	7.22e-03	5.98e-02	0.2620	2.02e-01	-0.167000	1.80e-02	4.96e-02
Thrombin signalling through proteinase activated receptors (PARs)	22	1.14e-01	3.58e-01	0.2620	-1.77e-01	-0.194000	1.52e-01	1.16e-01
Gastrin-CREB signalling pathway via PKC and MAPK	16	2.07e-01	5.00e-01	0.2620	-1.91e-01	-0.179000	1.87e-01	2.14e-01
RNA Polymerase III Transcription Initiation	28	5.52e-02	2.25e-01	0.2620	2.09e-02	-0.261000	8.48e-01	1.69e-02
Stabilization of p53	43	1.05e-02	7.74e-02	0.2620	2.33e-01	-0.118000	8.20e-03	1.79e-01
Purine ribonucleoside monophosphate biosynthesis	11	3.29e-01	6.50e-01	0.2620	-4.71e-02	-0.257000	7.87e-01	1.40e-01
Regulation of APC/C activators between G1/S and early anaphase	65	1.12e-03	1.36e-02	0.2610	2.44e-01	-0.093100	6.94e-04	1.95e-01
RA biosynthesis pathway	13	2.58e-01	5.68e-01	0.2600	2.50e-01	-0.072500	1.19e-01	6.51e-01
Ub-specific processing proteases	150	1.61e-07	6.97e-06	0.2600	2.18e-01	-0.141000	4.13e-06	2.93e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	1.70e-02	1.07e-01	0.2600	2.30e-01	-0.121000	1.31e-02	1.91e-01
p53-Independent DNA Damage Response	39	1.70e-02	1.07e-01	0.2600	2.30e-01	-0.121000	1.31e-02	1.91e-01
p53-Independent G1/S DNA damage checkpoint	39	1.70e-02	1.07e-01	0.2600	2.30e-01	-0.121000	1.31e-02	1.91e-01
Ubiquitin-dependent degradation of Cyclin D	40	1.53e-02	1.01e-01	0.2600	2.30e-01	-0.120000	1.18e-02	1.90e-01
RET signaling	33	3.77e-02	1.83e-01	0.2600	-2.55e-01	-0.051000	1.14e-02	6.12e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	59	2.30e-03	2.37e-02	0.2590	2.44e-01	-0.086100	1.19e-03	2.53e-01
Biological oxidations	129	2.28e-06	8.36e-05	0.2590	2.57e-01	-0.032800	5.03e-07	5.21e-01
Major pathway of rRNA processing in the nucleolus and cytosol	110	1.18e-05	3.22e-04	0.2590	2.25e-01	-0.127000	4.59e-05	2.20e-02
TP53 Regulates Transcription of Death Receptors and Ligands	11	3.48e-01	6.69e-01	0.2580	-1.94e-01	-0.170000	2.64e-01	3.29e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	19	1.46e-01	4.23e-01	0.2570	6.92e-02	-0.247000	6.02e-01	6.19e-02
Regulation of ornithine decarboxylase (ODC)	42	1.36e-02	9.26e-02	0.2560	2.14e-01	-0.142000	1.67e-02	1.12e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	30	4.97e-02	2.11e-01	0.2560	2.51e-01	-0.050900	1.73e-02	6.30e-01
rRNA processing	124	3.74e-06	1.24e-04	0.2560	2.22e-01	-0.127000	2.12e-05	1.45e-02
Glyoxylate metabolism and glycine degradation	21	1.28e-01	3.87e-01	0.2550	6.34e-03	-0.255000	9.60e-01	4.31e-02
Cell-cell junction organization	26	7.87e-02	2.86e-01	0.2550	-1.38e-02	0.254000	9.03e-01	2.48e-02
FOXO-mediated transcription of cell death genes	13	2.85e-01	5.98e-01	0.2540	9.49e-03	0.254000	9.53e-01	1.13e-01
APC/C-mediated degradation of cell cycle proteins	72	8.96e-04	1.17e-02	0.2530	2.46e-01	-0.058100	3.07e-04	3.95e-01
Regulation of mitotic cell cycle	72	8.96e-04	1.17e-02	0.2530	2.46e-01	-0.058100	3.07e-04	3.95e-01
Cellular hexose transport	12	3.31e-01	6.53e-01	0.2530	-1.97e-01	-0.159000	2.38e-01	3.40e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	58	3.49e-03	3.32e-02	0.2520	2.34e-01	-0.093100	2.08e-03	2.20e-01
Laminin interactions	22	1.35e-01	3.98e-01	0.2510	-2.10e-01	-0.138000	8.78e-02	2.64e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	49	8.21e-03	6.45e-02	0.2510	2.00e-01	-0.151000	1.54e-02	6.76e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	23	1.13e-01	3.57e-01	0.2510	9.95e-03	-0.251000	9.34e-01	3.76e-02
Antigen processing-Cross presentation	75	8.46e-04	1.13e-02	0.2510	2.50e-01	-0.013600	1.81e-04	8.39e-01
CD209 (DC-SIGN) signaling	19	1.67e-01	4.49e-01	0.2500	-2.40e-02	0.249000	8.57e-01	6.08e-02
Dual incision in TC-NER	50	8.11e-03	6.44e-02	0.2490	2.21e-01	-0.116000	6.95e-03	1.57e-01
Base-Excision Repair, AP Site Formation	15	2.39e-01	5.45e-01	0.2490	6.89e-02	-0.239000	6.44e-01	1.08e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	20	1.46e-01	4.23e-01	0.2490	1.07e-01	-0.225000	4.09e-01	8.14e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	2.85e-01	5.98e-01	0.2480	-1.63e-01	0.188000	3.09e-01	2.42e-01
Interferon Signaling	128	7.37e-06	2.21e-04	0.2480	2.48e-01	-0.018900	1.38e-06	7.12e-01
Activation of gene expression by SREBF (SREBP)	39	3.18e-02	1.63e-01	0.2480	-2.04e-01	-0.141000	2.79e-02	1.27e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	26	1.00e-01	3.37e-01	0.2480	2.10e-01	0.131000	6.35e-02	2.48e-01
RHO GTPases Activate NADPH Oxidases	18	1.78e-01	4.63e-01	0.2480	1.93e-01	-0.155000	1.56e-01	2.55e-01
HS-GAG biosynthesis	21	1.35e-01	3.98e-01	0.2480	-1.26e-01	0.213000	3.17e-01	9.12e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	69	1.43e-03	1.65e-02	0.2470	1.37e-01	-0.206000	4.87e-02	3.18e-03
SCF-beta-TrCP mediated degradation of Emi1	43	1.73e-02	1.09e-01	0.2470	2.28e-01	-0.094800	9.62e-03	2.82e-01
Complement cascade	35	3.59e-02	1.75e-01	0.2470	1.87e-01	-0.161000	5.61e-02	9.88e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	9.33e-02	3.24e-01	0.2470	-2.47e-01	0.000267	2.95e-02	9.98e-01
Resolution of D-Loop Structures	27	9.40e-02	3.26e-01	0.2470	2.02e-01	0.141000	6.90e-02	2.05e-01
STING mediated induction of host immune responses	12	3.32e-01	6.53e-01	0.2460	2.43e-01	-0.036400	1.45e-01	8.27e-01
TRAF6 mediated IRF7 activation	15	2.71e-01	5.89e-01	0.2460	1.95e-01	0.150000	1.92e-01	3.15e-01
WNT5A-dependent internalization of FZD4	14	2.96e-01	6.10e-01	0.2460	-2.03e-01	-0.139000	1.90e-01	3.67e-01
Plasma lipoprotein remodeling	14	2.95e-01	6.09e-01	0.2460	-2.13e-01	-0.122000	1.67e-01	4.29e-01
Metabolism of amino acids and derivatives	225	8.87e-10	1.01e-07	0.2460	1.96e-01	-0.148000	4.50e-07	1.41e-04
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	14	2.93e-01	6.07e-01	0.2450	2.27e-01	0.094100	1.42e-01	5.42e-01
Sulfur amino acid metabolism	19	1.69e-01	4.53e-01	0.2450	1.29e-01	-0.208000	3.30e-01	1.16e-01
Homologous DNA Pairing and Strand Exchange	35	4.19e-02	1.94e-01	0.2440	2.38e-01	-0.052300	1.48e-02	5.93e-01
CDK-mediated phosphorylation and removal of Cdc6	58	4.78e-03	4.35e-02	0.2440	2.12e-01	-0.120000	5.25e-03	1.14e-01
NGF-stimulated transcription	33	4.70e-02	2.03e-01	0.2440	-1.69e-01	0.175000	9.27e-02	8.17e-02
MET activates PTK2 signaling	17	2.34e-01	5.41e-01	0.2440	-1.95e-01	-0.146000	1.65e-01	2.97e-01
Separation of Sister Chromatids	134	6.14e-06	1.93e-04	0.2430	2.38e-01	-0.049700	2.02e-06	3.22e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	14	2.75e-01	5.91e-01	0.2430	-1.51e-01	0.190000	3.27e-01	2.18e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	22	1.55e-01	4.28e-01	0.2430	-1.85e-01	-0.157000	1.33e-01	2.03e-01
Regulation of Apoptosis	40	2.61e-02	1.45e-01	0.2420	2.08e-01	-0.124000	2.30e-02	1.75e-01
p53-Dependent G1 DNA Damage Response	51	9.88e-03	7.35e-02	0.2420	2.14e-01	-0.113000	8.30e-03	1.64e-01
p53-Dependent G1/S DNA damage checkpoint	51	9.88e-03	7.35e-02	0.2420	2.14e-01	-0.113000	8.30e-03	1.64e-01
Glutathione conjugation	28	7.83e-02	2.85e-01	0.2410	1.90e-01	-0.149000	8.15e-02	1.74e-01
Initiation of Nuclear Envelope (NE) Reformation	17	2.17e-01	5.12e-01	0.2410	2.27e-01	-0.083300	1.06e-01	5.52e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	22	1.49e-01	4.25e-01	0.2410	-2.40e-01	-0.023900	5.14e-02	8.46e-01
CD28 co-stimulation	31	7.36e-02	2.74e-01	0.2410	2.22e-01	0.093400	3.27e-02	3.68e-01
Non-integrin membrane-ECM interactions	37	4.68e-02	2.03e-01	0.2400	-1.61e-01	-0.178000	8.95e-02	6.13e-02
Signaling by WNT in cancer	25	1.16e-01	3.60e-01	0.2400	-2.40e-01	0.003800	3.81e-02	9.74e-01
APC/C:Cdc20 mediated degradation of Securin	54	8.02e-03	6.44e-02	0.2400	1.98e-01	-0.135000	1.19e-02	8.67e-02
Nucleobase biosynthesis	13	3.38e-01	6.59e-01	0.2390	-7.38e-02	-0.227000	6.45e-01	1.56e-01
SUMOylation of DNA replication proteins	34	5.59e-02	2.27e-01	0.2390	2.38e-01	0.022600	1.65e-02	8.20e-01
Golgi Cisternae Pericentriolar Stack Reorganization	12	3.48e-01	6.69e-01	0.2390	2.24e-01	-0.082400	1.79e-01	6.21e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	3.50e-01	6.70e-01	0.2380	7.82e-02	-0.225000	6.39e-01	1.77e-01
Degradation of DVL	44	2.10e-02	1.26e-01	0.2370	1.81e-01	-0.153000	3.79e-02	7.87e-02
RHO GTPases Activate WASPs and WAVEs	34	6.38e-02	2.48e-01	0.2370	2.09e-01	0.111000	3.51e-02	2.62e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	41	2.89e-02	1.53e-01	0.2360	1.92e-01	-0.136000	3.36e-02	1.31e-01
Hh mutants abrogate ligand secretion	43	2.43e-02	1.38e-01	0.2360	1.82e-01	-0.149000	3.87e-02	9.12e-02
Olfactory Signaling Pathway	13	3.52e-01	6.72e-01	0.2360	-2.06e-01	-0.113000	1.97e-01	4.80e-01
Activation of BAD and translocation to mitochondria	14	3.05e-01	6.21e-01	0.2350	2.27e-01	-0.063400	1.42e-01	6.81e-01
Resolution of Abasic Sites (AP sites)	31	7.55e-02	2.79e-01	0.2330	2.25e-01	-0.062800	3.05e-02	5.45e-01
Autodegradation of the E3 ubiquitin ligase COP1	40	3.41e-02	1.70e-01	0.2330	2.00e-01	-0.119000	2.85e-02	1.91e-01
Class B/2 (Secretin family receptors)	40	4.43e-02	1.99e-01	0.2330	-1.95e-01	-0.127000	3.33e-02	1.63e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	25	1.32e-01	3.92e-01	0.2320	-2.32e-01	0.010500	4.50e-02	9.28e-01
Trafficking of AMPA receptors	25	1.32e-01	3.92e-01	0.2320	-2.32e-01	0.010500	4.50e-02	9.28e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	4.27e-01	7.31e-01	0.2310	1.07e-01	0.205000	5.38e-01	2.40e-01
Meiosis	43	2.89e-02	1.53e-01	0.2310	2.09e-01	-0.098800	1.80e-02	2.63e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	15	3.10e-01	6.27e-01	0.2310	-2.23e-01	-0.060900	1.36e-01	6.83e-01
G1/S DNA Damage Checkpoints	53	1.30e-02	8.97e-02	0.2310	2.11e-01	-0.091900	7.81e-03	2.48e-01
Generation of second messenger molecules	20	1.95e-01	4.86e-01	0.2300	2.17e-01	-0.078000	9.32e-02	5.46e-01
Scavenging by Class A Receptors	13	3.41e-01	6.61e-01	0.2300	-1.87e-01	0.134000	2.42e-01	4.04e-01
Diseases of glycosylation	105	1.81e-04	3.20e-03	0.2300	-1.63e-01	0.162000	4.06e-03	4.09e-03
Platelet calcium homeostasis	20	2.00e-01	4.92e-01	0.2290	-2.23e-01	0.055000	8.48e-02	6.70e-01
Prolactin receptor signaling	11	4.06e-01	7.16e-01	0.2290	-1.21e-01	0.195000	4.87e-01	2.63e-01
Defective CFTR causes cystic fibrosis	43	3.09e-02	1.59e-01	0.2290	2.14e-01	-0.083000	1.55e-02	3.47e-01
ER-Phagosome pathway	61	8.52e-03	6.62e-02	0.2290	2.29e-01	0.004710	2.03e-03	9.49e-01
Signaling by PDGF	46	2.35e-02	1.36e-01	0.2290	-1.68e-01	0.156000	4.95e-02	6.83e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	24	1.65e-01	4.46e-01	0.2280	1.24e-01	0.191000	2.92e-01	1.05e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	13	3.51e-01	6.70e-01	0.2280	1.11e-01	-0.199000	4.88e-01	2.15e-01
Telomere Extension By Telomerase	17	2.61e-01	5.73e-01	0.2270	2.23e-01	-0.047000	1.12e-01	7.37e-01
Signaling by ERBB2 TMD/JMD mutants	19	2.24e-01	5.23e-01	0.2270	-2.24e-01	0.041500	9.17e-02	7.54e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	25	1.36e-01	3.98e-01	0.2270	-1.00e-01	0.204000	3.85e-01	7.80e-02
Transcriptional regulation of pluripotent stem cells	14	3.46e-01	6.68e-01	0.2260	3.68e-02	0.223000	8.12e-01	1.48e-01
Activation of SMO	13	3.56e-01	6.77e-01	0.2260	-1.94e-01	0.116000	2.26e-01	4.68e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	61	8.13e-03	6.44e-02	0.2260	1.97e-01	-0.111000	7.97e-03	1.35e-01
Autodegradation of Cdh1 by Cdh1:APC/C	50	1.90e-02	1.16e-01	0.2250	1.61e-01	-0.158000	4.90e-02	5.39e-02
Cell death signalling via NRAGE, NRIF and NADE	62	7.72e-03	6.31e-02	0.2250	-1.94e-01	0.113000	8.23e-03	1.23e-01
APC/C:Cdc20 mediated degradation of Cyclin B	18	2.50e-01	5.58e-01	0.2250	2.19e-01	-0.049100	1.08e-01	7.18e-01
Aquaporin-mediated transport	33	8.73e-02	3.07e-01	0.2240	-2.17e-01	-0.056600	3.10e-02	5.74e-01
Caspase activation via extrinsic apoptotic signalling pathway	22	1.78e-01	4.63e-01	0.2240	-1.78e-01	0.136000	1.49e-01	2.69e-01
Degradation of GLI1 by the proteasome	47	2.58e-02	1.45e-01	0.2240	1.86e-01	-0.124000	2.73e-02	1.42e-01
Reproduction	52	1.75e-02	1.09e-01	0.2240	1.85e-01	-0.126000	2.13e-02	1.17e-01
Formation of the beta-catenin:TCF transactivating complex	29	1.05e-01	3.46e-01	0.2240	-1.93e-01	0.113000	7.20e-02	2.95e-01
DAP12 signaling	24	1.57e-01	4.31e-01	0.2230	2.00e-01	-0.098100	8.95e-02	4.06e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	4.78e-01	7.66e-01	0.2230	-2.21e-01	-0.026100	2.26e-01	8.86e-01
Netrin-1 signaling	42	4.34e-02	1.98e-01	0.2230	-1.62e-02	0.222000	8.56e-01	1.28e-02
Peroxisomal lipid metabolism	24	1.57e-01	4.31e-01	0.2230	1.84e-01	-0.126000	1.19e-01	2.87e-01
Trafficking and processing of endosomal TLR	11	4.37e-01	7.37e-01	0.2230	2.20e-01	-0.032000	2.06e-01	8.54e-01
Adrenaline,noradrenaline inhibits insulin secretion	18	2.72e-01	5.89e-01	0.2230	-7.63e-02	-0.209000	5.75e-01	1.25e-01
MECP2 regulates neuronal receptors and channels	11	4.59e-01	7.52e-01	0.2220	1.51e-01	0.162000	3.85e-01	3.52e-01
Ion homeostasis	41	4.50e-02	2.01e-01	0.2210	-1.98e-01	0.099000	2.87e-02	2.73e-01
Voltage gated Potassium channels	24	1.61e-01	4.38e-01	0.2210	-1.69e-01	0.142000	1.52e-01	2.29e-01
Sema4D in semaphorin signaling	22	2.10e-01	5.03e-01	0.2210	-2.05e-01	-0.082300	9.65e-02	5.04e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	22	1.88e-01	4.76e-01	0.2210	1.49e-01	-0.163000	2.28e-01	1.86e-01
Signaling by NOTCH2	21	2.05e-01	4.99e-01	0.2200	-1.13e-01	0.189000	3.71e-01	1.33e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	4.26e-02	1.96e-01	0.2190	1.63e-01	-0.147000	6.84e-02	9.88e-02
Deadenylation of mRNA	20	2.50e-01	5.58e-01	0.2190	1.83e-01	0.121000	1.57e-01	3.50e-01
NIK-->noncanonical NF-kB signaling	45	3.48e-02	1.71e-01	0.2190	1.82e-01	-0.122000	3.53e-02	1.56e-01
Signaling by NOTCH3	39	5.51e-02	2.25e-01	0.2180	-1.43e-01	0.165000	1.22e-01	7.53e-02
Processing of Capped Intronless Pre-mRNA	19	2.75e-01	5.91e-01	0.2170	1.71e-01	0.134000	1.97e-01	3.12e-01
AKT phosphorylates targets in the cytosol	13	3.93e-01	7.09e-01	0.2170	4.52e-02	-0.212000	7.78e-01	1.85e-01
Thromboxane signalling through TP receptor	15	3.60e-01	6.79e-01	0.2160	-2.01e-01	-0.079700	1.78e-01	5.93e-01
SHC1 events in EGFR signaling	11	4.78e-01	7.66e-01	0.2160	-1.34e-01	-0.170000	4.43e-01	3.30e-01
Uptake and actions of bacterial toxins	24	1.80e-01	4.66e-01	0.2160	-2.08e-01	0.058800	7.84e-02	6.18e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	59	1.45e-02	9.63e-02	0.2160	1.96e-01	-0.090400	9.36e-03	2.30e-01
Nitric oxide stimulates guanylate cyclase	19	2.58e-01	5.68e-01	0.2160	-2.08e-01	0.056500	1.17e-01	6.70e-01
Nicotinate metabolism	22	2.04e-01	4.99e-01	0.2150	1.14e-01	-0.183000	3.53e-01	1.38e-01
FRS-mediated FGFR4 signaling	12	4.37e-01	7.37e-01	0.2150	-1.53e-02	-0.215000	9.27e-01	1.98e-01
Presynaptic depolarization and calcium channel opening	11	4.64e-01	7.54e-01	0.2150	-2.13e-01	0.026200	2.21e-01	8.81e-01
Purine catabolism	16	3.21e-01	6.41e-01	0.2140	9.63e-02	-0.191000	5.05e-01	1.86e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	42	5.15e-02	2.16e-01	0.2140	9.48e-02	-0.191000	2.88e-01	3.19e-02
Response of EIF2AK1 (HRI) to heme deficiency	11	4.61e-01	7.52e-01	0.2130	-7.46e-02	0.200000	6.68e-01	2.51e-01
Phosphorylation of the APC/C	17	3.04e-01	6.19e-01	0.2130	1.91e-01	-0.092700	1.72e-01	5.08e-01
Glycogen breakdown (glycogenolysis)	14	3.75e-01	6.90e-01	0.2120	-1.24e-01	0.172000	4.22e-01	2.66e-01
rRNA modification in the nucleus and cytosol	46	4.19e-02	1.94e-01	0.2120	7.97e-02	-0.196000	3.50e-01	2.16e-02
DNA Double-Strand Break Repair	105	9.27e-04	1.18e-02	0.2110	2.11e-01	0.002030	1.88e-04	9.71e-01
activated TAK1 mediates p38 MAPK activation	17	3.38e-01	6.59e-01	0.2110	-1.62e-01	-0.135000	2.47e-01	3.37e-01
Antimicrobial peptides	12	4.57e-01	7.52e-01	0.2090	2.08e-01	0.022600	2.12e-01	8.92e-01
Keratan sulfate/keratin metabolism	24	1.94e-01	4.86e-01	0.2090	-1.70e-01	0.122000	1.49e-01	3.03e-01
Synthesis of PA	23	2.23e-01	5.21e-01	0.2090	-2.09e-01	-0.004730	8.30e-02	9.69e-01
GLI3 is processed to GLI3R by the proteasome	46	4.51e-02	2.01e-01	0.2080	1.79e-01	-0.107000	3.62e-02	2.10e-01
Regulation of RUNX3 expression and activity	42	6.02e-02	2.41e-01	0.2070	1.75e-01	-0.112000	5.01e-02	2.11e-01
G alpha (12/13) signalling events	65	1.43e-02	9.60e-02	0.2070	-2.02e-01	0.044500	4.80e-03	5.35e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	23	2.38e-01	5.45e-01	0.2070	1.92e-01	0.077700	1.11e-01	5.19e-01
Degradation of GLI2 by the proteasome	46	4.66e-02	2.03e-01	0.2070	1.63e-01	-0.127000	5.61e-02	1.36e-01
Mitochondrial tRNA aminoacylation	15	3.98e-01	7.14e-01	0.2070	-1.29e-01	-0.161000	3.88e-01	2.79e-01
Cell-extracellular matrix interactions	14	4.05e-01	7.15e-01	0.2060	-2.05e-01	0.026100	1.85e-01	8.66e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	71	1.10e-02	7.94e-02	0.2060	2.06e-01	0.003710	2.69e-03	9.57e-01
Amplification of signal from the kinetochores	71	1.10e-02	7.94e-02	0.2060	2.06e-01	0.003710	2.69e-03	9.57e-01
Costimulation by the CD28 family	52	3.77e-02	1.83e-01	0.2060	2.05e-01	0.022900	1.06e-02	7.75e-01
IRF3-mediated induction of type I IFN	10	5.23e-01	7.87e-01	0.2060	2.03e-01	-0.038600	2.67e-01	8.33e-01
IKK complex recruitment mediated by RIP1	15	3.74e-01	6.89e-01	0.2060	-7.42e-02	0.192000	6.19e-01	1.97e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	15	3.71e-01	6.89e-01	0.2060	-1.23e-01	0.165000	4.10e-01	2.69e-01
PKA activation in glucagon signalling	16	3.58e-01	6.78e-01	0.2050	-2.02e-01	0.036100	1.62e-01	8.02e-01
O-linked glycosylation	65	1.41e-02	9.55e-02	0.2050	-1.20e-01	0.167000	9.57e-02	2.01e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	56	2.56e-02	1.45e-01	0.2050	1.75e-01	-0.108000	2.39e-02	1.63e-01
VxPx cargo-targeting to cilium	17	3.40e-01	6.61e-01	0.2050	-2.08e-02	0.204000	8.82e-01	1.46e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	5.04e-01	7.82e-01	0.2050	-1.91e-02	-0.204000	9.13e-01	2.42e-01
Regulation of RAS by GAPs	54	3.22e-02	1.64e-01	0.2050	2.00e-01	-0.042900	1.11e-02	5.86e-01
Glycosphingolipid metabolism	31	1.55e-01	4.28e-01	0.2040	-1.77e-01	-0.103000	8.90e-02	3.23e-01
Regulation of TP53 Activity through Methylation	11	4.90e-01	7.71e-01	0.2040	-1.04e-01	0.175000	5.49e-01	3.14e-01
Uptake and function of anthrax toxins	11	4.89e-01	7.71e-01	0.2040	-1.56e-01	0.131000	3.70e-01	4.52e-01
PRC2 methylates histones and DNA	12	4.61e-01	7.52e-01	0.2040	1.84e-01	-0.088600	2.71e-01	5.95e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	16	3.83e-01	7.00e-01	0.2040	-1.04e-01	-0.175000	4.71e-01	2.26e-01
Citric acid cycle (TCA cycle)	18	3.21e-01	6.41e-01	0.2040	1.99e-01	-0.042100	1.44e-01	7.57e-01
p75 NTR receptor-mediated signalling	75	8.69e-03	6.67e-02	0.2020	-1.53e-01	0.131000	2.19e-02	5.01e-02
Downstream TCR signaling	69	1.36e-02	9.26e-02	0.2010	1.88e-01	-0.073000	7.13e-03	2.95e-01
Inflammasomes	18	3.21e-01	6.41e-01	0.2010	-1.13e-01	0.167000	4.08e-01	2.21e-01
GAB1 signalosome	14	4.23e-01	7.31e-01	0.2010	-1.99e-01	0.026400	1.97e-01	8.64e-01
Acyl chain remodelling of PG	10	5.39e-01	8.02e-01	0.2010	-1.94e-01	0.052100	2.89e-01	7.76e-01
PI3K events in ERBB2 signaling	14	4.15e-01	7.24e-01	0.2010	-1.52e-01	0.130000	3.24e-01	3.98e-01
Cell Cycle, Mitotic	402	6.79e-11	1.42e-08	0.2000	2.00e-01	-0.007260	8.98e-12	8.04e-01
Mitotic Metaphase and Anaphase	182	1.58e-05	4.23e-04	0.2000	1.87e-01	-0.071000	1.49e-05	9.98e-02
Metabolism of folate and pterines	14	4.35e-01	7.37e-01	0.2000	-1.99e-01	-0.014000	1.97e-01	9.28e-01
Regulation of TP53 Degradation	29	1.75e-01	4.63e-01	0.2000	1.99e-01	-0.013100	6.36e-02	9.03e-01
Signaling by ROBO receptors	133	3.82e-04	5.85e-03	0.1990	1.99e-01	-0.002410	7.44e-05	9.62e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	4.03e-01	7.15e-01	0.1990	1.51e-01	0.129000	2.95e-01	3.72e-01
Peroxisomal protein import	48	5.18e-02	2.16e-01	0.1990	1.40e-01	-0.141000	9.33e-02	9.13e-02
Chemokine receptors bind chemokines	27	2.09e-01	5.03e-01	0.1990	1.92e-01	0.051000	8.41e-02	6.47e-01
Meiotic recombination	21	2.74e-01	5.90e-01	0.1990	1.49e-01	-0.131000	2.36e-01	2.99e-01
Ca2+ pathway	49	5.87e-02	2.38e-01	0.1990	-1.93e-01	-0.047800	1.97e-02	5.63e-01
Mitotic Anaphase	181	1.91e-05	5.01e-04	0.1980	1.83e-01	-0.075500	2.20e-05	8.07e-02
NCAM signaling for neurite out-growth	47	6.47e-02	2.51e-01	0.1980	-1.97e-01	-0.027200	1.99e-02	7.47e-01
Cell Cycle	496	5.99e-13	4.79e-10	0.1980	1.98e-01	-0.000211	6.61e-14	9.94e-01
DAP12 interactions	27	1.92e-01	4.82e-01	0.1980	1.66e-01	-0.108000	1.36e-01	3.30e-01
CS/DS degradation	11	5.13e-01	7.84e-01	0.1980	-1.83e-01	0.076600	2.94e-01	6.60e-01
HDR through Single Strand Annealing (SSA)	31	1.57e-01	4.31e-01	0.1980	1.94e-01	-0.038900	6.16e-02	7.08e-01
TCR signaling	89	5.05e-03	4.47e-02	0.1980	1.93e-01	-0.042500	1.66e-03	4.89e-01
RAS processing	17	3.56e-01	6.77e-01	0.1970	1.40e-01	-0.138000	3.17e-01	3.23e-01
Synthesis of very long-chain fatty acyl-CoAs	14	4.43e-01	7.40e-01	0.1970	4.89e-04	0.197000	9.97e-01	2.02e-01
Dectin-1 mediated noncanonical NF-kB signaling	46	6.24e-02	2.46e-01	0.1970	1.62e-01	-0.111000	5.69e-02	1.92e-01
Global Genome Nucleotide Excision Repair (GG-NER)	68	1.69e-02	1.07e-01	0.1970	1.71e-01	-0.097300	1.48e-02	1.66e-01
Negative regulators of DDX58/IFIH1 signaling	24	2.36e-01	5.44e-01	0.1960	1.33e-01	-0.144000	2.59e-01	2.22e-01
RUNX2 regulates bone development	27	2.02e-01	4.96e-01	0.1960	-7.89e-02	0.179000	4.78e-01	1.07e-01
APC-Cdc20 mediated degradation of Nek2A	20	3.15e-01	6.32e-01	0.1960	1.95e-01	-0.013000	1.31e-01	9.20e-01
Antiviral mechanism by IFN-stimulated genes	56	3.90e-02	1.85e-01	0.1950	1.92e-01	-0.037000	1.31e-02	6.32e-01
SHC-mediated cascade:FGFR1	12	4.97e-01	7.76e-01	0.1950	1.89e-01	-0.048600	2.57e-01	7.71e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	29	1.94e-01	4.86e-01	0.1950	-1.94e-01	-0.009220	7.02e-02	9.32e-01
p38MAPK events	12	4.94e-01	7.74e-01	0.1940	1.66e-01	-0.101000	3.20e-01	5.45e-01
Signaling by the B Cell Receptor (BCR)	96	4.17e-03	3.91e-02	0.1940	1.88e-01	-0.046400	1.47e-03	4.33e-01
Prostacyclin signalling through prostacyclin receptor	11	5.49e-01	8.13e-01	0.1930	-7.56e-02	-0.178000	6.64e-01	3.07e-01
mRNA 3'-end processing	42	1.03e-01	3.44e-01	0.1930	1.70e-01	0.091500	5.63e-02	3.05e-01
RNA Polymerase II Transcription Termination	49	7.25e-02	2.74e-01	0.1930	1.47e-01	0.125000	7.46e-02	1.30e-01
COPII-mediated vesicle transport	51	5.25e-02	2.18e-01	0.1930	-1.63e-01	0.103000	4.45e-02	2.02e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	10	5.60e-01	8.17e-01	0.1930	-1.55e-01	0.115000	3.97e-01	5.30e-01
Nephrin family interactions	19	3.59e-01	6.79e-01	0.1930	7.67e-02	0.177000	5.63e-01	1.83e-01
ABC transporter disorders	53	4.71e-02	2.03e-01	0.1930	1.63e-01	-0.103000	4.06e-02	1.95e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	5.88e-01	8.27e-01	0.1920	-1.32e-01	-0.140000	4.71e-01	4.44e-01
Semaphorin interactions	59	3.49e-02	1.71e-01	0.1920	-8.26e-02	0.173000	2.73e-01	2.15e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR)	31	1.69e-01	4.54e-01	0.1920	-1.02e-01	0.162000	3.24e-01	1.18e-01
Deubiquitination	215	5.71e-06	1.84e-04	0.1920	1.71e-01	-0.087700	1.77e-05	2.73e-02
Biosynthesis of specialized proresolving mediators (SPMs)	13	4.77e-01	7.66e-01	0.1920	1.73e-01	-0.082500	2.80e-01	6.07e-01
Other interleukin signaling	17	4.07e-01	7.16e-01	0.1910	8.54e-02	0.171000	5.42e-01	2.23e-01
Reduction of cytosolic Ca++ levels	10	5.66e-01	8.21e-01	0.1910	-1.06e-01	0.159000	5.61e-01	3.85e-01
Adenylate cyclase activating pathway	10	5.92e-01	8.29e-01	0.1910	-1.43e-01	-0.127000	4.35e-01	4.87e-01
Complex I biogenesis	39	1.11e-01	3.53e-01	0.1910	8.32e-02	-0.172000	3.69e-01	6.35e-02
Tight junction interactions	11	5.58e-01	8.16e-01	0.1900	5.94e-02	0.181000	7.33e-01	2.99e-01
A tetrasaccharide linker sequence is required for GAG synthesis	19	3.60e-01	6.79e-01	0.1900	-1.89e-01	-0.019700	1.54e-01	8.82e-01
Nonhomologous End-Joining (NHEJ)	29	2.10e-01	5.03e-01	0.1900	1.89e-01	0.016900	7.78e-02	8.75e-01
Signaling by FGFR	58	4.68e-02	2.03e-01	0.1900	4.95e-02	0.183000	5.15e-01	1.58e-02
Nucleotide salvage	18	3.72e-01	6.89e-01	0.1890	1.82e-01	-0.051200	1.81e-01	7.07e-01
Regulation of PTEN stability and activity	53	5.30e-02	2.19e-01	0.1890	1.51e-01	-0.114000	5.83e-02	1.52e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	4.39e-01	7.38e-01	0.1880	1.71e-01	0.078800	2.37e-01	5.86e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	4.39e-01	7.38e-01	0.1880	1.71e-01	0.078800	2.37e-01	5.86e-01
Mitotic Spindle Checkpoint	86	1.03e-02	7.63e-02	0.1880	1.87e-01	-0.016800	2.71e-03	7.88e-01
Infection with Mycobacterium tuberculosis	21	3.21e-01	6.41e-01	0.1880	1.82e-01	-0.046800	1.49e-01	7.11e-01
Arachidonic acid metabolism	36	1.48e-01	4.25e-01	0.1880	1.87e-01	-0.013000	5.19e-02	8.92e-01
Energy dependent regulation of mTOR by LKB1-AMPK	25	2.67e-01	5.82e-01	0.1880	-1.88e-01	0.000924	1.04e-01	9.94e-01
ADP signalling through P2Y purinoceptor 1	17	4.24e-01	7.31e-01	0.1870	-1.07e-01	-0.154000	4.45e-01	2.73e-01
Hyaluronan uptake and degradation	10	5.97e-01	8.29e-01	0.1870	1.82e-01	0.043700	3.19e-01	8.11e-01
Translation of structural proteins	21	3.42e-01	6.61e-01	0.1870	-1.78e-01	-0.055900	1.57e-01	6.58e-01
Cell junction organization	47	7.73e-02	2.83e-01	0.1870	-1.30e-01	0.134000	1.22e-01	1.13e-01
HS-GAG degradation	17	4.05e-01	7.15e-01	0.1870	-1.83e-01	0.038500	1.92e-01	7.83e-01
The citric acid (TCA) cycle and respiratory electron transport	111	2.56e-03	2.53e-02	0.1860	1.09e-01	-0.151000	4.83e-02	6.00e-03
BBSome-mediated cargo-targeting to cilium	17	4.00e-01	7.14e-01	0.1860	1.57e-01	-0.100000	2.63e-01	4.75e-01
Pre-NOTCH Expression and Processing	43	9.90e-02	3.37e-01	0.1860	-1.53e-01	0.106000	8.28e-02	2.32e-01
EML4 and NUDC in mitotic spindle formation	75	2.12e-02	1.27e-01	0.1860	1.86e-01	0.005130	5.49e-03	9.39e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	5.21e-01	7.87e-01	0.1850	1.73e-01	0.065400	2.79e-01	6.83e-01
Signaling by KIT in disease	20	3.73e-01	6.89e-01	0.1850	1.17e-01	0.143000	3.64e-01	2.67e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	3.73e-01	6.89e-01	0.1850	1.17e-01	0.143000	3.64e-01	2.67e-01
Presynaptic function of Kainate receptors	13	5.29e-01	7.93e-01	0.1850	-1.37e-01	-0.124000	3.92e-01	4.40e-01
Defective B4GALT7 causes EDS, progeroid type	16	4.29e-01	7.32e-01	0.1840	-1.54e-01	0.101000	2.85e-01	4.86e-01
SHC-mediated cascade:FGFR4	11	5.64e-01	8.21e-01	0.1840	5.57e-02	-0.175000	7.49e-01	3.14e-01
RAF activation	32	1.98e-01	4.89e-01	0.1840	8.78e-04	-0.184000	9.93e-01	7.22e-02
ABC transporters in lipid homeostasis	12	5.47e-01	8.12e-01	0.1830	1.22e-02	0.183000	9.42e-01	2.72e-01
Interleukin-6 signaling	10	5.96e-01	8.29e-01	0.1830	1.64e-01	-0.079500	3.68e-01	6.63e-01
FGFR2 alternative splicing	18	4.01e-01	7.15e-01	0.1820	-3.78e-02	0.178000	7.82e-01	1.90e-01
Nucleotide Excision Repair	86	1.24e-02	8.63e-02	0.1820	1.68e-01	-0.070900	7.23e-03	2.56e-01
Extracellular matrix organization	211	3.00e-05	7.12e-04	0.1820	-1.81e-01	0.017900	6.22e-06	6.55e-01
Response of Mtb to phagocytosis	18	3.94e-01	7.10e-01	0.1820	1.39e-01	-0.117000	3.06e-01	3.90e-01
Metabolism of nitric oxide: NOS3 activation and regulation	14	5.15e-01	7.85e-01	0.1820	1.21e-01	0.136000	4.34e-01	3.80e-01
Interconversion of nucleotide di- and triphosphates	22	3.28e-01	6.50e-01	0.1810	5.85e-02	-0.172000	6.35e-01	1.63e-01
Miscellaneous transport and binding events	18	3.99e-01	7.14e-01	0.1810	-1.55e-01	0.094200	2.56e-01	4.89e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	33	1.86e-01	4.74e-01	0.1810	-1.57e-01	0.090900	1.20e-01	3.66e-01
TRP channels	12	5.48e-01	8.12e-01	0.1810	4.31e-02	-0.176000	7.96e-01	2.92e-01
Pentose phosphate pathway	13	5.14e-01	7.85e-01	0.1810	1.33e-01	-0.123000	4.07e-01	4.44e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	30	2.41e-01	5.45e-01	0.1810	-6.42e-02	-0.169000	5.43e-01	1.10e-01
HIV Transcription Elongation	30	2.41e-01	5.45e-01	0.1810	-6.42e-02	-0.169000	5.43e-01	1.10e-01
Tat-mediated elongation of the HIV-1 transcript	30	2.41e-01	5.45e-01	0.1810	-6.42e-02	-0.169000	5.43e-01	1.10e-01
Blood group systems biosynthesis	11	5.84e-01	8.24e-01	0.1800	-9.73e-03	0.180000	9.55e-01	3.02e-01
Triglyceride metabolism	22	3.30e-01	6.53e-01	0.1800	-8.84e-02	0.157000	4.73e-01	2.03e-01
Glycerophospholipid biosynthesis	87	1.69e-02	1.07e-01	0.1800	-1.69e-01	-0.060600	6.44e-03	3.29e-01
Phase I - Functionalization of compounds	59	5.30e-02	2.19e-01	0.1800	1.65e-01	-0.070800	2.83e-02	3.48e-01
Transcriptional Regulation by MECP2	42	1.21e-01	3.74e-01	0.1800	-1.04e-01	0.146000	2.42e-01	1.02e-01
Integrin signaling	24	3.12e-01	6.30e-01	0.1800	1.14e-02	-0.179000	9.23e-01	1.29e-01
Phase 2 - plateau phase	17	4.38e-01	7.38e-01	0.1790	-1.79e-01	0.007730	2.01e-01	9.56e-01
Post-translational protein phosphorylation	67	3.47e-02	1.71e-01	0.1790	-1.33e-01	0.121000	6.01e-02	8.84e-02
CD28 dependent PI3K/Akt signaling	20	3.97e-01	7.14e-01	0.1790	1.27e-01	0.126000	3.25e-01	3.29e-01
Platelet Aggregation (Plug Formation)	25	2.94e-01	6.08e-01	0.1790	4.31e-02	-0.174000	7.10e-01	1.33e-01
EGFR downregulation	24	3.13e-01	6.31e-01	0.1790	-1.77e-01	0.026100	1.34e-01	8.25e-01
Sphingolipid metabolism	62	5.93e-02	2.38e-01	0.1780	-1.30e-01	-0.122000	7.74e-02	9.62e-02
Role of phospholipids in phagocytosis	26	2.92e-01	6.07e-01	0.1780	-1.68e-02	-0.178000	8.82e-01	1.17e-01
Formation of tubulin folding intermediates by CCT/TriC	16	4.72e-01	7.60e-01	0.1780	-3.31e-02	-0.175000	8.19e-01	2.25e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	28	2.80e-01	5.94e-01	0.1780	-1.30e-01	-0.122000	2.34e-01	2.66e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	35	2.05e-01	4.99e-01	0.1770	9.95e-02	0.147000	3.08e-01	1.33e-01
NR1H2 and NR1H3-mediated signaling	35	2.05e-01	4.99e-01	0.1770	-1.57e-01	-0.082700	1.09e-01	3.98e-01
Glucagon signaling in metabolic regulation	24	3.38e-01	6.59e-01	0.1770	-1.58e-01	-0.079900	1.81e-01	4.99e-01
Host Interactions of HIV factors	100	8.66e-03	6.67e-02	0.1760	1.63e-01	-0.067300	5.06e-03	2.46e-01
RAB geranylgeranylation	45	1.17e-01	3.63e-01	0.1760	1.63e-01	-0.066500	5.90e-02	4.41e-01
Pre-NOTCH Transcription and Translation	30	2.37e-01	5.44e-01	0.1760	-9.37e-02	0.149000	3.75e-01	1.59e-01
Regulation of RUNX2 expression and activity	57	7.37e-02	2.74e-01	0.1760	1.75e-01	0.013700	2.25e-02	8.58e-01
Degradation of the extracellular matrix	70	4.31e-02	1.97e-01	0.1750	-1.70e-01	-0.042600	1.41e-02	5.38e-01
Interleukin-6 family signaling	17	4.65e-01	7.54e-01	0.1750	1.70e-01	0.041800	2.25e-01	7.65e-01
TP53 Regulates Transcription of DNA Repair Genes	48	1.04e-01	3.46e-01	0.1750	6.04e-02	-0.164000	4.69e-01	4.92e-02
Branched-chain amino acid catabolism	20	3.87e-01	7.03e-01	0.1740	1.42e-01	-0.101000	2.71e-01	4.35e-01
Diseases of metabolism	163	5.03e-04	7.11e-03	0.1740	-1.53e-01	0.082600	7.53e-04	6.98e-02
Respiratory electron transport	66	4.43e-02	1.99e-01	0.1740	1.26e-01	-0.120000	7.68e-02	9.20e-02
Regulation of KIT signaling	16	4.98e-01	7.76e-01	0.1740	1.28e-01	0.118000	3.75e-01	4.14e-01
Formation of HIV elongation complex in the absence of HIV Tat	31	2.53e-01	5.62e-01	0.1740	-4.38e-02	-0.168000	6.73e-01	1.05e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	73	3.39e-02	1.70e-01	0.1730	-1.19e-01	0.125000	7.92e-02	6.51e-02
Heparan sulfate/heparin (HS-GAG) metabolism	37	1.86e-01	4.74e-01	0.1720	-1.67e-01	0.042600	7.88e-02	6.54e-01
Nuclear Pore Complex (NPC) Disassembly	27	3.13e-01	6.31e-01	0.1720	1.56e-01	0.074200	1.62e-01	5.05e-01
Ion transport by P-type ATPases	34	2.08e-01	5.01e-01	0.1720	-1.29e-01	0.114000	1.94e-01	2.50e-01
TP53 Regulates Transcription of Cell Cycle Genes	44	1.53e-01	4.28e-01	0.1720	1.51e-01	0.082700	8.42e-02	3.43e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	5.81e-01	8.24e-01	0.1720	-4.26e-02	0.166000	7.98e-01	3.18e-01
RIPK1-mediated regulated necrosis	14	5.55e-01	8.16e-01	0.1710	1.16e-01	0.126000	4.54e-01	4.14e-01
Regulated Necrosis	14	5.55e-01	8.16e-01	0.1710	1.16e-01	0.126000	4.54e-01	4.14e-01
Loss of Nlp from mitotic centrosomes	59	7.31e-02	2.74e-01	0.1710	-3.11e-02	0.168000	6.80e-01	2.57e-02
Loss of proteins required for interphase microtubule organization from the centrosome	59	7.31e-02	2.74e-01	0.1710	-3.11e-02	0.168000	6.80e-01	2.57e-02
tRNA Aminoacylation	20	4.32e-01	7.34e-01	0.1710	-1.46e-01	-0.088300	2.59e-01	4.94e-01
Activation of NF-kappaB in B cells	55	8.35e-02	2.97e-01	0.1700	1.36e-01	-0.102000	8.10e-02	1.90e-01
ER Quality Control Compartment (ERQC)	12	5.81e-01	8.24e-01	0.1700	-1.17e-01	0.124000	4.85e-01	4.57e-01
Sema3A PAK dependent Axon repulsion	15	5.12e-01	7.84e-01	0.1700	-7.03e-02	0.154000	6.37e-01	3.01e-01
E3 ubiquitin ligases ubiquitinate target proteins	26	3.33e-01	6.54e-01	0.1690	1.66e-01	0.031300	1.42e-01	7.83e-01
SHC-mediated cascade:FGFR3	12	5.85e-01	8.24e-01	0.1690	1.29e-01	-0.109000	4.39e-01	5.13e-01
Keratan sulfate biosynthesis	20	4.10e-01	7.19e-01	0.1690	-1.29e-01	0.109000	3.17e-01	4.01e-01
MicroRNA (miRNA) biogenesis	15	5.22e-01	7.87e-01	0.1690	-1.67e-01	0.022900	2.62e-01	8.78e-01
Downregulation of ERBB2 signaling	20	4.32e-01	7.34e-01	0.1690	-1.65e-01	-0.035500	2.02e-01	7.83e-01
Hedgehog ligand biogenesis	46	1.30e-01	3.90e-01	0.1690	1.33e-01	-0.104000	1.18e-01	2.24e-01
Integration of energy metabolism	85	2.83e-02	1.51e-01	0.1690	-1.67e-01	-0.023200	7.85e-03	7.12e-01
FCERI mediated NF-kB activation	64	5.91e-02	2.38e-01	0.1690	1.37e-01	-0.098200	5.82e-02	1.75e-01
Regulation of TP53 Expression and Degradation	30	2.81e-01	5.95e-01	0.1680	1.68e-01	-0.001690	1.12e-01	9.87e-01
RNA Polymerase I Transcription Termination	21	4.33e-01	7.36e-01	0.1660	-1.02e-01	-0.132000	4.21e-01	2.96e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	71	4.74e-02	2.03e-01	0.1660	1.29e-01	-0.104000	6.01e-02	1.29e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	19	4.46e-01	7.43e-01	0.1660	5.89e-02	-0.155000	6.57e-01	2.42e-01
DAG and IP3 signaling	36	2.26e-01	5.26e-01	0.1660	-1.66e-01	0.003470	8.52e-02	9.71e-01
Post NMDA receptor activation events	53	1.05e-01	3.46e-01	0.1660	-1.52e-01	0.065500	5.52e-02	4.10e-01
PECAM1 interactions	11	6.47e-01	8.46e-01	0.1660	1.33e-01	0.098900	4.45e-01	5.70e-01
Signaling by NOTCH4	65	6.21e-02	2.46e-01	0.1660	1.27e-01	-0.107000	7.78e-02	1.37e-01
Iron uptake and transport	41	1.86e-01	4.74e-01	0.1650	-9.70e-04	-0.165000	9.91e-01	6.70e-02
G alpha (z) signalling events	34	2.64e-01	5.77e-01	0.1650	-1.13e-01	-0.121000	2.55e-01	2.23e-01
PI-3K cascade:FGFR1	12	6.21e-01	8.30e-01	0.1650	1.52e-01	0.065100	3.62e-01	6.96e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	55	1.17e-01	3.63e-01	0.1650	1.27e-01	0.105000	1.02e-01	1.80e-01
The NLRP3 inflammasome	13	5.76e-01	8.24e-01	0.1650	-1.21e-01	0.112000	4.51e-01	4.84e-01
Trafficking of GluR2-containing AMPA receptors	14	5.61e-01	8.18e-01	0.1650	-1.62e-01	0.031300	2.95e-01	8.40e-01
Interaction between L1 and Ankyrins	23	3.80e-01	6.96e-01	0.1650	-8.09e-02	0.143000	5.02e-01	2.34e-01
Downstream signaling events of B Cell Receptor (BCR)	67	6.39e-02	2.48e-01	0.1650	1.62e-01	-0.029700	2.21e-02	6.75e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	19	4.58e-01	7.52e-01	0.1640	1.61e-01	-0.030700	2.23e-01	8.17e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	4.58e-01	7.52e-01	0.1640	1.61e-01	-0.030700	2.23e-01	8.17e-01
Regulation of necroptotic cell death	12	6.28e-01	8.35e-01	0.1640	9.55e-02	0.133000	5.67e-01	4.24e-01
Signaling by TGFB family members	76	4.73e-02	2.03e-01	0.1640	1.62e-03	0.164000	9.81e-01	1.35e-02
Interleukin receptor SHC signaling	20	4.37e-01	7.37e-01	0.1640	5.66e-02	-0.154000	6.61e-01	2.34e-01
Formation of the cornified envelope	17	5.08e-01	7.83e-01	0.1640	-1.85e-02	-0.163000	8.95e-01	2.46e-01
Signaling by FGFR1	35	2.57e-01	5.68e-01	0.1640	7.00e-02	0.148000	4.74e-01	1.30e-01
Sphingolipid de novo biosynthesis	31	3.02e-01	6.17e-01	0.1640	-8.25e-02	-0.141000	4.27e-01	1.74e-01
RHO GTPases activate CIT	18	4.86e-01	7.71e-01	0.1630	6.78e-03	-0.163000	9.60e-01	2.31e-01
Stimuli-sensing channels	52	1.23e-01	3.77e-01	0.1630	-1.60e-01	0.028900	4.56e-02	7.19e-01
Intra-Golgi traffic	34	2.49e-01	5.56e-01	0.1630	-1.48e-01	0.067800	1.36e-01	4.94e-01
p130Cas linkage to MAPK signaling for integrins	12	6.10e-01	8.29e-01	0.1620	9.07e-02	-0.135000	5.87e-01	4.19e-01
Signaling by NOTCH1	61	8.22e-02	2.95e-01	0.1620	-1.31e-01	0.095300	7.63e-02	1.98e-01
Retrograde transport at the Trans-Golgi-Network	40	1.94e-01	4.86e-01	0.1620	-9.62e-02	0.130000	2.93e-01	1.54e-01
Carboxyterminal post-translational modifications of tubulin	25	3.88e-01	7.03e-01	0.1620	-7.27e-02	-0.145000	5.29e-01	2.11e-01
Mitotic Prometaphase	152	3.19e-03	3.11e-02	0.1620	1.54e-01	0.047800	1.06e-03	3.11e-01
Vasopressin regulates renal water homeostasis via Aquaporins	30	3.22e-01	6.42e-01	0.1610	-1.46e-01	-0.067800	1.65e-01	5.21e-01
FCGR3A-mediated phagocytosis	58	1.11e-01	3.53e-01	0.1610	1.53e-01	0.052700	4.47e-02	4.88e-01
Leishmania phagocytosis	58	1.11e-01	3.53e-01	0.1610	1.53e-01	0.052700	4.47e-02	4.88e-01
Parasite infection	58	1.11e-01	3.53e-01	0.1610	1.53e-01	0.052700	4.47e-02	4.88e-01
FRS-mediated FGFR3 signaling	13	5.94e-01	8.29e-01	0.1610	5.80e-02	-0.150000	7.18e-01	3.48e-01
Keratinization	22	4.12e-01	7.21e-01	0.1610	1.09e-01	-0.118000	3.75e-01	3.40e-01
Biosynthesis of DHA-derived SPMs	11	6.43e-01	8.44e-01	0.1600	1.19e-01	-0.107000	4.95e-01	5.37e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	11	6.49e-01	8.46e-01	0.1600	-4.78e-02	0.153000	7.84e-01	3.81e-01
Amine ligand-binding receptors	11	6.56e-01	8.51e-01	0.1600	1.60e-01	0.004030	3.59e-01	9.82e-01
PCP/CE pathway	75	6.09e-02	2.43e-01	0.1600	-4.06e-02	-0.154000	5.44e-01	2.09e-02
Cellular response to heat stress	72	6.29e-02	2.47e-01	0.1600	-1.59e-01	0.016800	2.00e-02	8.06e-01
SUMO E3 ligases SUMOylate target proteins	131	8.14e-03	6.44e-02	0.1600	1.47e-01	0.062600	3.79e-03	2.17e-01
Potential therapeutics for SARS	32	3.09e-01	6.27e-01	0.1600	1.34e-01	0.086300	1.89e-01	3.98e-01
TNFR2 non-canonical NF-kB pathway	62	8.75e-02	3.07e-01	0.1590	1.27e-01	-0.095100	8.33e-02	1.96e-01
Gluconeogenesis	24	4.03e-01	7.15e-01	0.1590	-1.59e-01	0.002880	1.78e-01	9.81e-01
Mitochondrial calcium ion transport	16	5.56e-01	8.16e-01	0.1590	-5.26e-02	-0.150000	7.16e-01	3.00e-01
GRB2 events in ERBB2 signaling	14	5.98e-01	8.29e-01	0.1580	-1.52e-01	-0.046200	3.26e-01	7.65e-01
Transport of Mature Transcript to Cytoplasm	62	1.05e-01	3.46e-01	0.1580	1.44e-01	0.065700	4.99e-02	3.72e-01
DNA Repair	222	2.63e-04	4.35e-03	0.1580	1.58e-01	-0.006540	5.20e-05	8.67e-01
Oncogene Induced Senescence	27	3.61e-01	6.79e-01	0.1580	-1.76e-02	0.157000	8.75e-01	1.58e-01
Nuclear Envelope (NE) Reassembly	57	1.13e-01	3.57e-01	0.1580	5.10e-02	-0.149000	5.06e-01	5.13e-02
RNA Polymerase III Abortive And Retractive Initiation	33	2.83e-01	5.96e-01	0.1570	5.74e-02	-0.147000	5.68e-01	1.45e-01
RNA Polymerase III Transcription	33	2.83e-01	5.96e-01	0.1570	5.74e-02	-0.147000	5.68e-01	1.45e-01
Formation of RNA Pol II elongation complex	42	2.15e-01	5.10e-01	0.1570	-2.71e-02	-0.155000	7.62e-01	8.23e-02
RNA Polymerase II Transcription Elongation	42	2.15e-01	5.10e-01	0.1570	-2.71e-02	-0.155000	7.62e-01	8.23e-02
Signaling by EGFR in Cancer	18	5.23e-01	7.87e-01	0.1570	-1.47e-01	-0.055200	2.80e-01	6.85e-01
Formation of TC-NER Pre-Incision Complex	38	2.33e-01	5.39e-01	0.1570	1.11e-01	-0.111000	2.38e-01	2.37e-01
Interleukin-2 family signaling	33	2.83e-01	5.96e-01	0.1570	1.30e-01	-0.087600	1.97e-01	3.84e-01
Mitochondrial protein import	49	1.64e-01	4.45e-01	0.1560	1.38e-02	-0.156000	8.67e-01	5.95e-02
AURKA Activation by TPX2	61	1.08e-01	3.52e-01	0.1560	-5.31e-03	0.156000	9.43e-01	3.54e-02
Late endosomal microautophagy	22	4.65e-01	7.54e-01	0.1550	-8.69e-02	-0.129000	4.81e-01	2.96e-01
Cellular response to hypoxia	56	1.23e-01	3.77e-01	0.1550	1.16e-01	-0.103000	1.35e-01	1.82e-01
G-protein activation	15	5.96e-01	8.29e-01	0.1550	-1.21e-01	-0.096200	4.16e-01	5.19e-01
Ion channel transport	100	2.92e-02	1.54e-01	0.1540	-1.54e-01	-0.005050	7.86e-03	9.31e-01
Defective B3GAT3 causes JDSSDHD	16	5.53e-01	8.16e-01	0.1540	-1.22e-01	0.093600	3.97e-01	5.17e-01
WNT ligand biogenesis and trafficking	12	6.65e-01	8.57e-01	0.1540	-1.08e-01	-0.109000	5.18e-01	5.11e-01
Signaling by high-kinase activity BRAF mutants	30	3.46e-01	6.68e-01	0.1530	6.30e-03	-0.153000	9.52e-01	1.46e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	47	1.78e-01	4.63e-01	0.1530	-1.09e-01	0.108000	1.98e-01	1.99e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	47	1.78e-01	4.63e-01	0.1530	-1.09e-01	0.108000	1.98e-01	1.99e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	47	1.78e-01	4.63e-01	0.1530	-1.09e-01	0.108000	1.98e-01	1.99e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	47	1.78e-01	4.63e-01	0.1530	-1.09e-01	0.108000	1.98e-01	1.99e-01
Signaling by NOTCH1 in Cancer	47	1.78e-01	4.63e-01	0.1530	-1.09e-01	0.108000	1.98e-01	1.99e-01
SUMOylation of DNA damage response and repair proteins	56	1.48e-01	4.25e-01	0.1530	1.40e-01	0.062100	6.97e-02	4.22e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	4.48e-01	7.44e-01	0.1530	-6.88e-02	0.137000	5.77e-01	2.66e-01
SUMOylation	137	9.34e-03	7.08e-02	0.1530	1.48e-01	0.041000	2.92e-03	4.08e-01
Caspase activation via Death Receptors in the presence of ligand	15	5.80e-01	8.24e-01	0.1530	-7.75e-02	0.132000	6.04e-01	3.78e-01
Translation	178	1.74e-03	1.86e-02	0.1520	1.32e-01	-0.075900	2.41e-03	8.19e-02
Assembly Of The HIV Virion	10	7.17e-01	8.83e-01	0.1520	-1.07e-01	-0.108000	5.59e-01	5.53e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	7.18e-01	8.83e-01	0.1510	-1.32e-01	-0.074900	4.71e-01	6.82e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	38	2.80e-01	5.94e-01	0.1510	-4.45e-02	-0.145000	6.35e-01	1.23e-01
Signaling by RAS mutants	38	2.80e-01	5.94e-01	0.1510	-4.45e-02	-0.145000	6.35e-01	1.23e-01
Signaling by moderate kinase activity BRAF mutants	38	2.80e-01	5.94e-01	0.1510	-4.45e-02	-0.145000	6.35e-01	1.23e-01
Signaling downstream of RAS mutants	38	2.80e-01	5.94e-01	0.1510	-4.45e-02	-0.145000	6.35e-01	1.23e-01
Signaling by ERBB2 KD Mutants	22	4.60e-01	7.52e-01	0.1510	-1.41e-01	0.056000	2.54e-01	6.49e-01
Deadenylation-dependent mRNA decay	44	2.27e-01	5.26e-01	0.1510	1.50e-01	0.020900	8.63e-02	8.10e-01
SUMOylation of intracellular receptors	25	4.17e-01	7.24e-01	0.1510	1.44e-01	-0.043800	2.11e-01	7.05e-01
Downstream signaling of activated FGFR1	21	5.04e-01	7.82e-01	0.1500	1.24e-01	0.084600	3.24e-01	5.02e-01
RNA Pol II CTD phosphorylation and interaction with CE	20	5.20e-01	7.87e-01	0.1500	-7.83e-02	-0.128000	5.44e-01	3.20e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	20	5.20e-01	7.87e-01	0.1500	-7.83e-02	-0.128000	5.44e-01	3.20e-01
Nucleobase catabolism	27	4.06e-01	7.16e-01	0.1500	1.48e-01	0.028600	1.85e-01	7.97e-01
ISG15 antiviral mechanism	50	1.85e-01	4.74e-01	0.1500	1.50e-01	0.000842	6.64e-02	9.92e-01
Metabolism of RNA	492	7.54e-08	3.65e-06	0.1500	1.41e-01	-0.051900	1.19e-07	5.09e-02
Autophagy	101	3.87e-02	1.85e-01	0.1500	-8.26e-02	-0.125000	1.52e-01	3.01e-02
DNA Double Strand Break Response	35	2.99e-01	6.12e-01	0.1500	1.41e-01	-0.049400	1.48e-01	6.13e-01
Vpr-mediated nuclear import of PICs	24	4.63e-01	7.53e-01	0.1490	8.35e-02	0.124000	4.79e-01	2.94e-01
Sialic acid metabolism	23	4.59e-01	7.52e-01	0.1490	-1.47e-01	0.027400	2.24e-01	8.20e-01
ER to Golgi Anterograde Transport	108	2.60e-02	1.45e-01	0.1490	-1.44e-01	0.038400	9.86e-03	4.91e-01
G-protein beta:gamma signalling	23	4.73e-01	7.61e-01	0.1490	-3.92e-02	-0.144000	7.45e-01	2.33e-01
tRNA modification in the nucleus and cytosol	32	3.38e-01	6.60e-01	0.1490	4.04e-02	-0.143000	6.93e-01	1.61e-01
Signaling by ERBB2 ECD mutants	15	6.11e-01	8.29e-01	0.1490	-1.48e-01	-0.018400	3.23e-01	9.02e-01
Diseases associated with the TLR signaling cascade	20	5.08e-01	7.83e-01	0.1490	-1.43e-01	0.041400	2.69e-01	7.48e-01
Diseases of Immune System	20	5.08e-01	7.83e-01	0.1490	-1.43e-01	0.041400	2.69e-01	7.48e-01
Signaling by FGFR3 in disease	16	5.77e-01	8.24e-01	0.1480	1.22e-01	-0.084400	3.98e-01	5.59e-01
Signaling by FGFR3 point mutants in cancer	16	5.77e-01	8.24e-01	0.1480	1.22e-01	-0.084400	3.98e-01	5.59e-01
Apoptotic cleavage of cellular proteins	31	3.47e-01	6.69e-01	0.1480	-6.87e-02	0.131000	5.08e-01	2.06e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	50	2.08e-01	5.01e-01	0.1480	-1.16e-01	-0.091700	1.55e-01	2.63e-01
Pausing and recovery of Tat-mediated HIV elongation	20	5.23e-01	7.87e-01	0.1480	-2.71e-02	-0.146000	8.34e-01	2.60e-01
Tat-mediated HIV elongation arrest and recovery	20	5.23e-01	7.87e-01	0.1480	-2.71e-02	-0.146000	8.34e-01	2.60e-01
Regulation of insulin secretion	58	1.49e-01	4.25e-01	0.1480	-1.48e-01	0.001620	5.15e-02	9.83e-01
Activation of G protein gated Potassium channels	16	5.82e-01	8.24e-01	0.1480	5.31e-02	-0.138000	7.13e-01	3.39e-01
G protein gated Potassium channels	16	5.82e-01	8.24e-01	0.1480	5.31e-02	-0.138000	7.13e-01	3.39e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	16	5.82e-01	8.24e-01	0.1480	5.31e-02	-0.138000	7.13e-01	3.39e-01
RIP-mediated NFkB activation via ZBP1	15	6.14e-01	8.29e-01	0.1480	-1.47e-01	-0.013900	3.24e-01	9.26e-01
FRS-mediated FGFR1 signaling	13	6.43e-01	8.44e-01	0.1470	1.13e-01	-0.094600	4.80e-01	5.55e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	17	5.84e-01	8.24e-01	0.1470	4.32e-02	0.141000	7.58e-01	3.16e-01
Regulation of actin dynamics for phagocytic cup formation	60	1.54e-01	4.28e-01	0.1470	1.31e-01	0.066400	7.97e-02	3.74e-01
G beta:gamma signalling through CDC42	12	6.90e-01	8.69e-01	0.1470	-9.71e-02	-0.110000	5.60e-01	5.11e-01
TRAF3-dependent IRF activation pathway	13	6.69e-01	8.57e-01	0.1460	1.24e-01	0.077900	4.39e-01	6.27e-01
Rho GTPase cycle	122	1.86e-02	1.15e-01	0.1460	-1.38e-01	0.048300	8.61e-03	3.58e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	16	5.89e-01	8.27e-01	0.1460	-8.47e-02	0.119000	5.58e-01	4.12e-01
SHC1 events in ERBB2 signaling	20	5.37e-01	8.00e-01	0.1460	-1.39e-01	-0.042100	2.81e-01	7.45e-01
HIV elongation arrest and recovery	21	5.13e-01	7.84e-01	0.1460	1.17e-03	-0.146000	9.93e-01	2.48e-01
Pausing and recovery of HIV elongation	21	5.13e-01	7.84e-01	0.1460	1.17e-03	-0.146000	9.93e-01	2.48e-01
ADP signalling through P2Y purinoceptor 12	14	6.39e-01	8.42e-01	0.1450	1.96e-02	-0.144000	8.99e-01	3.51e-01
VEGFR2 mediated vascular permeability	26	4.35e-01	7.37e-01	0.1450	-2.06e-02	0.144000	8.56e-01	2.05e-01
PIWI-interacting RNA (piRNA) biogenesis	11	7.15e-01	8.83e-01	0.1450	1.28e-01	0.068000	4.61e-01	6.96e-01
Notch-HLH transcription pathway	24	4.55e-01	7.50e-01	0.1450	-8.98e-02	0.114000	4.47e-01	3.34e-01
ZBP1(DAI) mediated induction of type I IFNs	18	5.78e-01	8.24e-01	0.1450	-1.29e-01	-0.066200	3.44e-01	6.27e-01
N-glycan antennae elongation in the medial/trans-Golgi	19	5.58e-01	8.16e-01	0.1440	1.86e-02	0.143000	8.88e-01	2.82e-01
Macroautophagy	90	7.02e-02	2.68e-01	0.1440	-9.74e-02	-0.106000	1.11e-01	8.35e-02
Interactions of Rev with host cellular proteins	26	4.48e-01	7.44e-01	0.1430	1.43e-01	-0.009400	2.08e-01	9.34e-01
TRAF6 mediated NF-kB activation	20	5.32e-01	7.94e-01	0.1430	-1.32e-01	0.053900	3.05e-01	6.76e-01
Erythropoietin activates RAS	12	6.84e-01	8.65e-01	0.1430	1.27e-01	-0.064600	4.45e-01	6.98e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	60	1.52e-01	4.28e-01	0.1430	-1.32e-01	0.054300	7.69e-02	4.68e-01
Regulation of PTEN mRNA translation	11	7.08e-01	8.81e-01	0.1430	-1.35e-01	0.046900	4.39e-01	7.88e-01
Interleukin-10 signaling	24	4.82e-01	7.69e-01	0.1430	1.43e-01	0.005470	2.27e-01	9.63e-01
Recruitment of NuMA to mitotic centrosomes	68	1.23e-01	3.77e-01	0.1420	-3.57e-02	0.138000	6.11e-01	5.01e-02
NEP/NS2 Interacts with the Cellular Export Machinery	23	5.05e-01	7.82e-01	0.1420	1.39e-01	0.030400	2.50e-01	8.01e-01
Signaling by EGFR	42	2.70e-01	5.88e-01	0.1420	-1.22e-01	0.071700	1.71e-01	4.22e-01
Assembly and cell surface presentation of NMDA receptors	17	6.10e-01	8.29e-01	0.1420	-6.05e-02	-0.128000	6.66e-01	3.61e-01
Platelet homeostasis	65	1.49e-01	4.25e-01	0.1420	-1.37e-01	-0.036000	5.66e-02	6.16e-01
PLC beta mediated events	46	2.40e-01	5.45e-01	0.1410	-1.21e-01	0.073100	1.56e-01	3.91e-01
Visual phototransduction	50	2.41e-01	5.45e-01	0.1410	-1.20e-01	-0.073100	1.42e-01	3.71e-01
Inactivation, recovery and regulation of the phototransduction cascade	17	6.09e-01	8.29e-01	0.1400	-1.39e-01	-0.022100	3.23e-01	8.75e-01
The phototransduction cascade	17	6.09e-01	8.29e-01	0.1400	-1.39e-01	-0.022100	3.23e-01	8.75e-01
UCH proteinases	68	1.32e-01	3.92e-01	0.1400	1.38e-01	-0.026200	4.99e-02	7.09e-01
Kinesins	36	3.64e-01	6.83e-01	0.1400	1.10e-01	0.085800	2.52e-01	3.73e-01
Mitochondrial Fatty Acid Beta-Oxidation	27	4.43e-01	7.40e-01	0.1390	1.22e-01	-0.066900	2.72e-01	5.48e-01
Amino acid transport across the plasma membrane	23	5.08e-01	7.83e-01	0.1390	1.38e-01	-0.018200	2.52e-01	8.80e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	26	4.66e-01	7.54e-01	0.1390	-1.38e-01	0.020700	2.25e-01	8.55e-01
MET activates RAP1 and RAC1	11	7.36e-01	8.94e-01	0.1390	1.25e-01	0.060900	4.75e-01	7.27e-01
G-protein mediated events	47	2.45e-01	5.52e-01	0.1390	-1.12e-01	0.081200	1.83e-01	3.36e-01
Metabolism of non-coding RNA	39	3.27e-01	6.48e-01	0.1380	1.38e-01	-0.002160	1.35e-01	9.81e-01
snRNP Assembly	39	3.27e-01	6.48e-01	0.1380	1.38e-01	-0.002160	1.35e-01	9.81e-01
Cell-Cell communication	78	1.01e-01	3.37e-01	0.1380	-5.78e-02	0.125000	3.78e-01	5.58e-02
Protein localization	123	2.67e-02	1.47e-01	0.1380	7.97e-02	-0.113000	1.28e-01	3.14e-02
CaM pathway	30	4.26e-01	7.31e-01	0.1380	-1.38e-01	-0.004460	1.92e-01	9.66e-01
Calmodulin induced events	30	4.26e-01	7.31e-01	0.1380	-1.38e-01	-0.004460	1.92e-01	9.66e-01
EPH-ephrin mediated repulsion of cells	41	2.98e-01	6.12e-01	0.1380	-1.15e-01	0.075400	2.02e-01	4.04e-01
Transcriptional Regulation by VENTX	34	3.74e-01	6.89e-01	0.1380	-1.33e-01	0.034500	1.79e-01	7.28e-01
Unblocking of NMDA receptors, glutamate binding and activation	15	6.61e-01	8.55e-01	0.1370	-1.30e-01	-0.043400	3.82e-01	7.71e-01
Degradation of beta-catenin by the destruction complex	70	1.33e-01	3.93e-01	0.1370	1.24e-01	-0.056900	7.23e-02	4.11e-01
M Phase	282	4.20e-04	6.30e-03	0.1370	1.37e-01	-0.006900	8.63e-05	8.43e-01
Signaling by NTRK3 (TRKC)	17	6.28e-01	8.35e-01	0.1370	-4.08e-02	-0.131000	7.71e-01	3.52e-01
Physiological factors	11	7.28e-01	8.89e-01	0.1370	-1.25e-01	0.054100	4.72e-01	7.56e-01
Metabolism of nucleotides	77	1.08e-01	3.52e-01	0.1360	8.49e-02	-0.107000	1.98e-01	1.06e-01
Myogenesis	21	5.57e-01	8.16e-01	0.1360	-1.23e-02	0.135000	9.22e-01	2.83e-01
MAP2K and MAPK activation	32	4.17e-01	7.24e-01	0.1350	-7.16e-03	-0.135000	9.44e-01	1.86e-01
Cell recruitment (pro-inflammatory response)	18	6.09e-01	8.29e-01	0.1350	-1.75e-02	0.134000	8.98e-01	3.26e-01
Purinergic signaling in leishmaniasis infection	18	6.09e-01	8.29e-01	0.1350	-1.75e-02	0.134000	8.98e-01	3.26e-01
Adaptive Immune System	542	1.09e-06	4.42e-05	0.1350	1.27e-01	0.045300	5.79e-07	7.46e-02
Synthesis of glycosylphosphatidylinositol (GPI)	14	6.75e-01	8.60e-01	0.1340	-1.19e-01	0.061800	4.40e-01	6.89e-01
FGFR2 mutant receptor activation	17	6.19e-01	8.30e-01	0.1340	-9.90e-02	0.090900	4.80e-01	5.17e-01
Transport to the Golgi and subsequent modification	131	2.65e-02	1.46e-01	0.1340	-1.19e-01	0.062300	1.91e-02	2.19e-01
RUNX2 regulates osteoblast differentiation	22	5.50e-01	8.13e-01	0.1330	-4.45e-02	0.125000	7.18e-01	3.09e-01
TBC/RABGAPs	35	4.14e-01	7.24e-01	0.1320	-9.77e-02	-0.089400	3.17e-01	3.60e-01
mRNA decay by 5' to 3' exoribonuclease	13	7.20e-01	8.84e-01	0.1320	7.32e-02	0.110000	6.48e-01	4.91e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	6.35e-01	8.40e-01	0.1320	-1.29e-01	0.027900	3.56e-01	8.42e-01
Synaptic adhesion-like molecules	17	6.52e-01	8.49e-01	0.1320	-1.07e-01	-0.077200	4.44e-01	5.82e-01
Transcriptional activation of mitochondrial biogenesis	49	2.79e-01	5.94e-01	0.1320	-5.58e-03	-0.132000	9.46e-01	1.10e-01
Chaperone Mediated Autophagy	13	7.17e-01	8.83e-01	0.1320	-2.91e-02	-0.129000	8.56e-01	4.22e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	6.81e-01	8.63e-01	0.1320	-1.29e-01	-0.028500	3.88e-01	8.49e-01
Processing of Capped Intron-Containing Pre-mRNA	180	1.10e-02	7.94e-02	0.1310	1.29e-01	0.024200	2.96e-03	5.77e-01
mRNA Splicing - Major Pathway	133	3.50e-02	1.71e-01	0.1310	1.30e-01	0.016600	9.89e-03	7.42e-01
Deactivation of the beta-catenin transactivating complex	31	4.46e-01	7.42e-01	0.1300	-1.25e-01	0.037900	2.30e-01	7.15e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	12	7.33e-01	8.93e-01	0.1290	-1.14e-01	0.061200	4.96e-01	7.14e-01
Class I MHC mediated antigen processing & presentation	289	1.12e-03	1.36e-02	0.1290	1.17e-01	0.053500	6.63e-04	1.20e-01
TICAM1, RIP1-mediated IKK complex recruitment	12	7.45e-01	8.98e-01	0.1290	2.10e-02	0.127000	9.00e-01	4.47e-01
PKMTs methylate histone lysines	35	4.17e-01	7.24e-01	0.1290	-1.28e-02	0.128000	8.96e-01	1.91e-01
RNA Polymerase I Promoter Escape	21	6.08e-01	8.29e-01	0.1290	-8.37e-02	-0.097500	5.07e-01	4.39e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	14	7.02e-01	8.79e-01	0.1280	4.08e-02	-0.121000	7.92e-01	4.32e-01
Vitamin B5 (pantothenate) metabolism	12	7.54e-01	9.04e-01	0.1280	7.93e-02	0.100000	6.34e-01	5.47e-01
PI3K Cascade	29	4.88e-01	7.71e-01	0.1280	-1.42e-02	0.127000	8.95e-01	2.37e-01
Synthesis of bile acids and bile salts	22	5.92e-01	8.29e-01	0.1280	4.09e-02	0.121000	7.40e-01	3.26e-01
B-WICH complex positively regulates rRNA expression	24	5.66e-01	8.21e-01	0.1280	1.18e-01	0.047800	3.16e-01	6.85e-01
Signaling by ERBB2 in Cancer	23	5.59e-01	8.17e-01	0.1270	-1.09e-01	0.065700	3.65e-01	5.86e-01
Ephrin signaling	19	6.22e-01	8.30e-01	0.1270	-1.17e-01	0.050000	3.77e-01	7.06e-01
Constitutive Signaling by Overexpressed ERBB2	10	7.86e-01	9.23e-01	0.1270	-1.35e-02	-0.126000	9.41e-01	4.89e-01
Class I peroxisomal membrane protein import	15	7.05e-01	8.79e-01	0.1270	6.93e-02	0.107000	6.42e-01	4.75e-01
RNA Polymerase III Transcription Termination	18	6.36e-01	8.40e-01	0.1270	1.05e-01	-0.071200	4.40e-01	6.01e-01
Beta-catenin phosphorylation cascade	16	6.70e-01	8.57e-01	0.1270	-6.91e-02	0.106000	6.32e-01	4.62e-01
Signaling by SCF-KIT	42	3.71e-01	6.89e-01	0.1270	2.48e-02	0.124000	7.82e-01	1.64e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	34	4.32e-01	7.34e-01	0.1270	1.16e-01	-0.049500	2.40e-01	6.17e-01
CASP8 activity is inhibited	10	7.94e-01	9.26e-01	0.1260	7.11e-02	0.104000	6.97e-01	5.67e-01
Dimerization of procaspase-8	10	7.94e-01	9.26e-01	0.1260	7.11e-02	0.104000	6.97e-01	5.67e-01
Regulation by c-FLIP	10	7.94e-01	9.26e-01	0.1260	7.11e-02	0.104000	6.97e-01	5.67e-01
FOXO-mediated transcription of cell cycle genes	15	6.90e-01	8.69e-01	0.1260	-5.64e-02	0.113000	7.05e-01	4.49e-01
Constitutive Signaling by EGFRvIII	15	7.06e-01	8.79e-01	0.1260	-1.17e-01	-0.046600	4.31e-01	7.55e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	15	7.06e-01	8.79e-01	0.1260	-1.17e-01	-0.046600	4.31e-01	7.55e-01
Signaling by EGFRvIII in Cancer	15	7.06e-01	8.79e-01	0.1260	-1.17e-01	-0.046600	4.31e-01	7.55e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	15	7.06e-01	8.79e-01	0.1260	-1.17e-01	-0.046600	4.31e-01	7.55e-01
Asymmetric localization of PCP proteins	52	2.91e-01	6.05e-01	0.1260	-8.21e-03	-0.126000	9.19e-01	1.16e-01
Rev-mediated nuclear export of HIV RNA	25	5.56e-01	8.16e-01	0.1260	1.24e-01	0.022200	2.83e-01	8.48e-01
RHO GTPases activate PKNs	31	4.88e-01	7.71e-01	0.1260	-3.66e-02	-0.120000	7.24e-01	2.47e-01
PKA activation	17	6.68e-01	8.57e-01	0.1250	-1.23e-01	0.022300	3.80e-01	8.74e-01
mRNA Splicing	141	3.98e-02	1.88e-01	0.1240	1.24e-01	0.006160	1.11e-02	9.00e-01
Inositol phosphate metabolism	41	4.03e-01	7.15e-01	0.1240	-7.81e-02	-0.096700	3.87e-01	2.85e-01
Regulation of beta-cell development	21	6.08e-01	8.29e-01	0.1240	-1.18e-01	0.037400	3.48e-01	7.67e-01
Regulation of signaling by CBL	18	6.65e-01	8.57e-01	0.1240	1.22e-01	0.020200	3.70e-01	8.82e-01
Negative regulation of FGFR2 signaling	21	6.06e-01	8.29e-01	0.1240	-6.35e-02	0.106000	6.14e-01	3.99e-01
Listeria monocytogenes entry into host cells	15	7.00e-01	8.78e-01	0.1240	-1.03e-01	0.068700	4.91e-01	6.45e-01
Nuclear Events (kinase and transcription factor activation)	55	2.70e-01	5.88e-01	0.1240	-9.26e-02	0.081800	2.35e-01	2.95e-01
EPHA-mediated growth cone collapse	13	7.39e-01	8.94e-01	0.1230	-3.05e-02	0.119000	8.49e-01	4.56e-01
Regulation of PLK1 Activity at G2/M Transition	71	2.03e-01	4.99e-01	0.1230	1.54e-02	0.122000	8.23e-01	7.53e-02
Signalling to ERKs	32	4.71e-01	7.60e-01	0.1230	6.41e-02	-0.105000	5.31e-01	3.04e-01
Negative epigenetic regulation of rRNA expression	36	4.28e-01	7.32e-01	0.1230	9.83e-02	-0.073900	3.08e-01	4.43e-01
Asparagine N-linked glycosylation	217	6.73e-03	5.68e-02	0.1230	-1.09e-01	0.057100	5.96e-03	1.49e-01
Nuclear signaling by ERBB4	24	5.73e-01	8.24e-01	0.1230	-1.16e-01	0.039600	3.24e-01	7.37e-01
Protein ubiquitination	42	3.83e-01	7.00e-01	0.1230	1.20e-01	-0.025000	1.79e-01	7.79e-01
Post-translational modification: synthesis of GPI-anchored proteins	55	2.78e-01	5.94e-01	0.1220	-7.02e-02	0.100000	3.68e-01	1.99e-01
Regulation of TNFR1 signaling	25	5.79e-01	8.24e-01	0.1220	1.19e-01	0.025800	3.03e-01	8.23e-01
Glycosaminoglycan metabolism	89	1.31e-01	3.92e-01	0.1220	-1.09e-01	0.053400	7.50e-02	3.85e-01
Centrosome maturation	69	2.11e-01	5.03e-01	0.1210	-4.21e-02	0.114000	5.46e-01	1.03e-01
Recruitment of mitotic centrosome proteins and complexes	69	2.11e-01	5.03e-01	0.1210	-4.21e-02	0.114000	5.46e-01	1.03e-01
NS1 Mediated Effects on Host Pathways	27	5.64e-01	8.21e-01	0.1210	1.11e-01	0.046900	3.17e-01	6.73e-01
Lysosome Vesicle Biogenesis	27	5.57e-01	8.16e-01	0.1210	-1.20e-01	-0.012100	2.80e-01	9.14e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	15	7.18e-01	8.83e-01	0.1210	1.20e-01	-0.015200	4.23e-01	9.19e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	8.06e-01	9.36e-01	0.1200	1.19e-01	-0.008850	5.14e-01	9.61e-01
FCERI mediated Ca+2 mobilization	25	5.99e-01	8.29e-01	0.1200	8.71e-02	0.081800	4.51e-01	4.79e-01
DNA Damage/Telomere Stress Induced Senescence	23	6.03e-01	8.29e-01	0.1190	1.10e-01	-0.046800	3.63e-01	6.98e-01
Hedgehog 'on' state	68	2.23e-01	5.21e-01	0.1190	9.12e-02	-0.076600	1.94e-01	2.75e-01
Signaling by Receptor Tyrosine Kinases	394	2.17e-04	3.79e-03	0.1190	-7.13e-02	0.095300	1.59e-02	1.28e-03
CTLA4 inhibitory signaling	21	6.41e-01	8.43e-01	0.1190	1.19e-01	-0.001920	3.46e-01	9.88e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	12	7.86e-01	9.23e-01	0.1180	6.44e-02	0.099000	6.99e-01	5.53e-01
Dopamine Neurotransmitter Release Cycle	14	7.55e-01	9.05e-01	0.1180	9.42e-02	0.071100	5.42e-01	6.45e-01
RNA Polymerase I Transcription	39	4.54e-01	7.50e-01	0.1180	-4.41e-02	-0.109000	6.34e-01	2.37e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	44	3.84e-01	7.01e-01	0.1180	-8.65e-02	0.080300	3.21e-01	3.57e-01
G2/M Transition	149	4.57e-02	2.03e-01	0.1180	1.18e-01	-0.007730	1.35e-02	8.71e-01
Diseases associated with glycosaminoglycan metabolism	33	4.90e-01	7.71e-01	0.1180	-9.25e-02	0.072900	3.58e-01	4.69e-01
Export of Viral Ribonucleoproteins from Nucleus	24	6.20e-01	8.30e-01	0.1180	9.44e-02	0.070100	4.23e-01	5.52e-01
Negative regulation of MAPK pathway	38	4.61e-01	7.52e-01	0.1180	-2.16e-02	-0.116000	8.18e-01	2.18e-01
Constitutive Signaling by AKT1 E17K in Cancer	24	6.10e-01	8.29e-01	0.1170	-7.74e-03	-0.117000	9.48e-01	3.21e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	35	4.71e-01	7.60e-01	0.1170	-9.57e-02	0.068100	3.28e-01	4.86e-01
RHO GTPases Activate ROCKs	18	6.81e-01	8.63e-01	0.1170	-9.71e-02	0.065200	4.76e-01	6.32e-01
RHO GTPases Activate Formins	94	1.54e-01	4.28e-01	0.1170	1.13e-01	0.031000	5.97e-02	6.04e-01
Chondroitin sulfate/dermatan sulfate metabolism	40	4.40e-01	7.38e-01	0.1170	-1.17e-01	0.006520	2.02e-01	9.43e-01
Nuclear import of Rev protein	24	6.12e-01	8.29e-01	0.1170	1.17e-01	-0.004190	3.23e-01	9.72e-01
Neddylation	180	2.40e-02	1.38e-01	0.1170	1.08e-01	-0.044300	1.29e-02	3.07e-01
Signaling by RAF1 mutants	35	4.93e-01	7.73e-01	0.1160	-6.55e-03	-0.116000	9.47e-01	2.34e-01
Regulation of TP53 Activity through Phosphorylation	76	2.05e-01	4.99e-01	0.1160	1.06e-01	-0.047300	1.10e-01	4.76e-01
Synthesis of substrates in N-glycan biosythesis	48	3.69e-01	6.89e-01	0.1160	-1.06e-01	0.048000	2.06e-01	5.66e-01
Regulation of RUNX1 Expression and Activity	16	7.15e-01	8.83e-01	0.1160	-9.23e-02	0.070100	5.23e-01	6.27e-01
Acyl chain remodelling of PE	15	7.40e-01	8.94e-01	0.1160	1.16e-01	0.004470	4.37e-01	9.76e-01
Signaling by TGF-beta Receptor Complex	57	3.34e-01	6.56e-01	0.1160	6.98e-02	0.092400	3.62e-01	2.28e-01
Mitotic G2-G2/M phases	151	5.03e-02	2.13e-01	0.1150	1.15e-01	-0.002900	1.47e-02	9.51e-01
Negative regulation of FGFR1 signaling	19	6.94e-01	8.72e-01	0.1150	5.25e-02	0.103000	6.92e-01	4.39e-01
NOTCH1 Intracellular Domain Regulates Transcription	40	4.40e-01	7.38e-01	0.1150	-6.04e-02	0.097800	5.09e-01	2.85e-01
Fc epsilon receptor (FCERI) signaling	111	1.07e-01	3.51e-01	0.1150	1.10e-01	-0.034400	4.64e-02	5.32e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	7.74e-01	9.19e-01	0.1150	1.15e-01	0.005280	4.74e-01	9.74e-01
SARS-CoV-1 Infection	36	4.86e-01	7.71e-01	0.1150	-1.10e-01	0.030300	2.52e-01	7.53e-01
Intraflagellar transport	35	4.90e-01	7.71e-01	0.1150	5.92e-02	-0.098000	5.45e-01	3.16e-01
Beta-catenin independent WNT signaling	117	1.12e-01	3.57e-01	0.1140	-6.18e-02	-0.096200	2.49e-01	7.30e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	5.23e-01	7.87e-01	0.1140	1.14e-01	-0.009870	2.59e-01	9.22e-01
Diseases of mitotic cell cycle	33	5.23e-01	7.87e-01	0.1140	1.14e-01	-0.009870	2.59e-01	9.22e-01
MAPK6/MAPK4 signaling	71	2.44e-01	5.50e-01	0.1130	6.08e-02	-0.095500	3.76e-01	1.65e-01
Chondroitin sulfate biosynthesis	16	7.38e-01	8.94e-01	0.1130	-1.13e-01	-0.008620	4.36e-01	9.52e-01
Signaling by NTRKs	119	9.87e-02	3.37e-01	0.1130	-1.06e-01	0.039000	4.66e-02	4.63e-01
GABA receptor activation	33	5.28e-01	7.92e-01	0.1120	2.99e-02	-0.108000	7.67e-01	2.81e-01
Smooth Muscle Contraction	34	5.29e-01	7.93e-01	0.1120	-1.12e-01	-0.012800	2.61e-01	8.98e-01
mRNA Capping	21	6.85e-01	8.65e-01	0.1120	-8.22e-02	-0.076200	5.14e-01	5.46e-01
Regulation of MECP2 expression and activity	25	6.25e-01	8.33e-01	0.1120	-1.12e-01	0.003990	3.34e-01	9.72e-01
ECM proteoglycans	40	4.88e-01	7.71e-01	0.1120	-9.08e-02	-0.065100	3.21e-01	4.76e-01
Regulation of TP53 Activity through Association with Co-factors	12	7.96e-01	9.28e-01	0.1110	-1.04e-01	0.039500	5.34e-01	8.13e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	31	5.67e-01	8.22e-01	0.1110	1.11e-01	0.007170	2.87e-01	9.45e-01
Transport of the SLBP Dependant Mature mRNA	25	6.44e-01	8.44e-01	0.1110	8.53e-02	0.070400	4.60e-01	5.42e-01
Striated Muscle Contraction	29	5.92e-01	8.29e-01	0.1100	-1.71e-02	-0.109000	8.73e-01	3.09e-01
Inwardly rectifying K+ channels	21	6.78e-01	8.61e-01	0.1100	1.63e-02	-0.109000	8.97e-01	3.87e-01
Signaling by FGFR2	49	4.08e-01	7.16e-01	0.1100	-1.15e-02	0.110000	8.90e-01	1.85e-01
Activation of GABAB receptors	30	5.79e-01	8.24e-01	0.1100	8.22e-03	-0.110000	9.38e-01	2.99e-01
GABA B receptor activation	30	5.79e-01	8.24e-01	0.1100	8.22e-03	-0.110000	9.38e-01	2.99e-01
Factors involved in megakaryocyte development and platelet production	98	1.74e-01	4.61e-01	0.1100	6.41e-03	0.110000	9.13e-01	6.14e-02
Transcriptional regulation by RUNX2	98	1.79e-01	4.63e-01	0.1090	1.08e-01	0.018700	6.58e-02	7.49e-01
Synthesis of PIPs at the Golgi membrane	14	7.70e-01	9.17e-01	0.1090	-8.73e-02	0.065600	5.72e-01	6.71e-01
Recycling pathway of L1	27	6.13e-01	8.29e-01	0.1090	-2.59e-02	0.106000	8.16e-01	3.42e-01
Detoxification of Reactive Oxygen Species	26	6.33e-01	8.40e-01	0.1090	1.08e-01	0.012700	3.41e-01	9.11e-01
N-Glycan antennae elongation	12	8.14e-01	9.37e-01	0.1080	3.05e-02	0.104000	8.55e-01	5.33e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	7.30e-01	8.91e-01	0.1080	-1.20e-03	0.108000	9.93e-01	4.28e-01
Cardiac conduction	97	1.73e-01	4.61e-01	0.1080	-7.96e-02	0.072800	1.76e-01	2.16e-01
Regulation of PTEN gene transcription	54	3.81e-01	6.98e-01	0.1080	-3.93e-02	0.100000	6.18e-01	2.03e-01
Signaling by ERBB2	38	5.30e-01	7.93e-01	0.1080	-9.40e-02	-0.052200	3.16e-01	5.78e-01
Disorders of transmembrane transporters	116	1.31e-01	3.91e-01	0.1070	1.03e-01	-0.030200	5.58e-02	5.76e-01
Defects in vitamin and cofactor metabolism	14	7.92e-01	9.26e-01	0.1070	-9.62e-02	-0.047100	5.33e-01	7.60e-01
COPI-independent Golgi-to-ER retrograde traffic	29	5.96e-01	8.29e-01	0.1070	-8.78e-02	0.061200	4.13e-01	5.69e-01
MET promotes cell motility	28	6.18e-01	8.30e-01	0.1070	3.41e-03	-0.107000	9.75e-01	3.28e-01
Glucose metabolism	70	3.02e-01	6.17e-01	0.1060	-1.05e-01	0.017900	1.30e-01	7.96e-01
Association of TriC/CCT with target proteins during biosynthesis	30	6.16e-01	8.30e-01	0.1060	7.52e-02	0.075000	4.76e-01	4.78e-01
Transport of Ribonucleoproteins into the Host Nucleus	23	6.88e-01	8.67e-01	0.1060	9.55e-02	0.045900	4.28e-01	7.03e-01
Circadian Clock	58	3.69e-01	6.89e-01	0.1060	1.01e-01	-0.031800	1.84e-01	6.76e-01
Anchoring of the basal body to the plasma membrane	80	2.52e-01	5.60e-01	0.1060	-4.29e-02	0.096700	5.07e-01	1.35e-01
Signaling by Hippo	19	7.23e-01	8.85e-01	0.1060	-2.42e-02	0.103000	8.55e-01	4.38e-01
Elastic fibre formation	34	5.71e-01	8.24e-01	0.1060	-1.04e-01	-0.019300	2.95e-01	8.45e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	5.35e-01	7.97e-01	0.1060	1.63e-02	0.104000	8.62e-01	2.66e-01
Potassium Channels	57	3.75e-01	6.89e-01	0.1060	-9.42e-02	0.047500	2.19e-01	5.35e-01
Plasma lipoprotein assembly, remodeling, and clearance	44	4.99e-01	7.78e-01	0.1050	-9.02e-02	-0.053100	3.01e-01	5.43e-01
Interactions of Vpr with host cellular proteins	26	6.68e-01	8.57e-01	0.1040	8.04e-02	0.066000	4.78e-01	5.60e-01
Nuclear Receptor transcription pathway	44	4.81e-01	7.68e-01	0.1040	4.17e-02	-0.095100	6.33e-01	2.75e-01
Metabolism of carbohydrates	217	3.17e-02	1.63e-01	0.1030	-1.02e-01	0.014100	9.71e-03	7.22e-01
cGMP effects	13	8.09e-01	9.36e-01	0.1030	-9.94e-02	0.027700	5.35e-01	8.63e-01
SUMOylation of DNA methylation proteins	15	7.82e-01	9.23e-01	0.1030	-9.03e-02	0.048800	5.45e-01	7.43e-01
Mitochondrial biogenesis	67	3.53e-01	6.74e-01	0.1030	-1.60e-02	-0.101000	8.21e-01	1.52e-01
Constitutive Signaling by Aberrant PI3K in Cancer	56	4.26e-01	7.31e-01	0.1020	2.56e-02	0.098800	7.41e-01	2.02e-01
Downregulation of TGF-beta receptor signaling	19	7.44e-01	8.97e-01	0.1020	1.02e-01	-0.001730	4.43e-01	9.90e-01
RHO GTPase Effectors	202	4.64e-02	2.03e-01	0.1020	1.02e-01	0.004400	1.32e-02	9.15e-01
SHC1 events in ERBB4 signaling	12	8.25e-01	9.40e-01	0.1020	5.23e-02	-0.087100	7.54e-01	6.01e-01
Death Receptor Signalling	112	1.67e-01	4.49e-01	0.1020	-6.52e-02	0.077900	2.34e-01	1.55e-01
Transport of the SLBP independent Mature mRNA	24	7.02e-01	8.79e-01	0.1010	6.29e-02	0.079400	5.94e-01	5.01e-01
Regulation of HSF1-mediated heat shock response	56	4.22e-01	7.30e-01	0.1000	-9.32e-02	0.036300	2.28e-01	6.38e-01
Ca-dependent events	32	6.17e-01	8.30e-01	0.1000	-9.98e-02	0.007310	3.29e-01	9.43e-01
Activation of NMDA receptors and postsynaptic events	62	3.86e-01	7.03e-01	0.1000	-9.39e-02	0.034400	2.02e-01	6.40e-01
Cytochrome P450 - arranged by substrate type	31	6.42e-01	8.43e-01	0.0997	8.34e-02	0.054700	4.22e-01	5.99e-01
mTORC1-mediated signalling	20	7.39e-01	8.94e-01	0.0992	9.56e-02	-0.026700	4.60e-01	8.36e-01
HIV Infection	176	7.09e-02	2.70e-01	0.0990	8.50e-02	-0.050700	5.26e-02	2.48e-01
Interleukin-37 signaling	18	7.74e-01	9.19e-01	0.0988	-9.34e-02	-0.032000	4.93e-01	8.14e-01
tRNA processing in the nucleus	47	5.10e-01	7.84e-01	0.0983	1.09e-02	0.097700	8.98e-01	2.47e-01
Mitochondrial translation initiation	64	3.99e-01	7.14e-01	0.0981	-3.24e-03	-0.098100	9.64e-01	1.75e-01
Mitotic Prophase	66	4.00e-01	7.15e-01	0.0981	8.59e-02	0.047400	2.28e-01	5.06e-01
G alpha (s) signalling events	80	3.26e-01	6.48e-01	0.0978	-9.55e-02	-0.021100	1.40e-01	7.45e-01
Muscle contraction	154	1.10e-01	3.53e-01	0.0976	-9.59e-02	0.018600	4.07e-02	6.92e-01
Cell surface interactions at the vascular wall	93	2.54e-01	5.63e-01	0.0976	5.07e-02	-0.083400	3.99e-01	1.65e-01
Glutamate and glutamine metabolism	12	8.49e-01	9.41e-01	0.0972	-5.62e-02	-0.079300	7.36e-01	6.35e-01
Antigen processing: Ubiquitination & Proteasome degradation	242	3.85e-02	1.84e-01	0.0971	8.95e-02	0.037600	1.69e-02	3.16e-01
Oncogenic MAPK signaling	68	3.89e-01	7.04e-01	0.0967	-9.64e-02	-0.008240	1.70e-01	9.07e-01
Signaling by BRAF and RAF fusions	54	4.80e-01	7.68e-01	0.0964	-9.31e-02	-0.025100	2.37e-01	7.50e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	8.64e-01	9.46e-01	0.0961	-7.30e-02	-0.062600	6.75e-01	7.19e-01
Neuronal System	244	3.29e-02	1.67e-01	0.0960	-8.76e-02	0.039400	1.91e-02	2.91e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	7.74e-01	9.19e-01	0.0960	3.82e-02	-0.088000	7.79e-01	5.18e-01
Cargo trafficking to the periciliary membrane	38	6.06e-01	8.29e-01	0.0956	8.25e-02	0.048400	3.79e-01	6.06e-01
Transcriptional regulation of white adipocyte differentiation	70	3.86e-01	7.03e-01	0.0956	4.57e-03	0.095400	9.47e-01	1.68e-01
Cargo recognition for clathrin-mediated endocytosis	72	3.71e-01	6.89e-01	0.0955	-9.48e-02	0.011300	1.65e-01	8.68e-01
Acyl chain remodelling of PC	17	7.85e-01	9.23e-01	0.0954	6.73e-02	-0.067600	6.31e-01	6.30e-01
Spry regulation of FGF signaling	12	8.44e-01	9.41e-01	0.0951	-6.20e-02	0.072200	7.10e-01	6.65e-01
IGF1R signaling cascade	37	6.14e-01	8.29e-01	0.0951	3.30e-02	0.089200	7.28e-01	3.48e-01
COPI-mediated anterograde transport	70	3.94e-01	7.10e-01	0.0951	-9.37e-02	-0.016200	1.76e-01	8.15e-01
RNA Polymerase I Transcription Initiation	35	6.36e-01	8.40e-01	0.0950	-6.18e-02	-0.072200	5.28e-01	4.60e-01
RNA Polymerase I Promoter Clearance	38	6.09e-01	8.29e-01	0.0948	-3.58e-02	-0.087800	7.02e-01	3.49e-01
Fcgamma receptor (FCGR) dependent phagocytosis	83	3.40e-01	6.61e-01	0.0947	8.82e-02	0.034600	1.66e-01	5.87e-01
C-type lectin receptors (CLRs)	101	2.58e-01	5.68e-01	0.0944	9.34e-02	-0.013300	1.05e-01	8.17e-01
Transport of Mature mRNA Derived from an Intronless Transcript	30	6.73e-01	8.59e-01	0.0943	9.35e-02	0.012300	3.76e-01	9.08e-01
SUMOylation of chromatin organization proteins	44	5.77e-01	8.24e-01	0.0933	6.20e-02	0.069700	4.77e-01	4.24e-01
Signaling by NTRK1 (TRKA)	104	2.47e-01	5.55e-01	0.0932	-7.81e-02	0.051000	1.70e-01	3.70e-01
Neurexins and neuroligins	37	6.18e-01	8.30e-01	0.0932	-9.32e-02	-0.002040	3.27e-01	9.83e-01
Rap1 signalling	15	8.25e-01	9.40e-01	0.0931	-9.14e-02	-0.017600	5.40e-01	9.06e-01
RORA activates gene expression	17	8.07e-01	9.36e-01	0.0928	-2.77e-02	-0.088600	8.43e-01	5.27e-01
PI-3K cascade:FGFR3	12	8.58e-01	9.42e-01	0.0922	9.21e-02	0.004590	5.81e-01	9.78e-01
Oxidative Stress Induced Senescence	55	4.84e-01	7.71e-01	0.0920	-7.30e-02	0.056000	3.49e-01	4.73e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	8.36e-01	9.41e-01	0.0919	-9.12e-02	0.011700	5.55e-01	9.40e-01
CLEC7A (Dectin-1) signaling	80	3.57e-01	6.77e-01	0.0919	8.82e-02	-0.025800	1.73e-01	6.91e-01
Downstream signaling of activated FGFR3	18	7.89e-01	9.25e-01	0.0919	7.90e-02	-0.046900	5.62e-01	7.30e-01
Activation of kainate receptors upon glutamate binding	20	7.85e-01	9.23e-01	0.0917	-5.65e-02	-0.072200	6.62e-01	5.77e-01
Calnexin/calreticulin cycle	15	8.29e-01	9.40e-01	0.0913	-2.51e-04	0.091300	9.99e-01	5.41e-01
EPH-Ephrin signaling	79	3.65e-01	6.85e-01	0.0910	-3.80e-02	0.082700	5.60e-01	2.05e-01
NoRC negatively regulates rRNA expression	33	6.54e-01	8.50e-01	0.0909	4.93e-02	-0.076400	6.24e-01	4.48e-01
MTOR signalling	35	6.60e-01	8.55e-01	0.0909	-5.77e-02	-0.070200	5.55e-01	4.73e-01
Downstream signaling of activated FGFR4	17	8.06e-01	9.36e-01	0.0907	2.85e-02	-0.086100	8.39e-01	5.39e-01
ERKs are inactivated	13	8.47e-01	9.41e-01	0.0907	4.04e-02	-0.081100	8.01e-01	6.13e-01
Transcriptional regulation of granulopoiesis	28	7.09e-01	8.81e-01	0.0904	9.03e-02	-0.003120	4.08e-01	9.77e-01
Metabolism of steroid hormones	18	8.06e-01	9.36e-01	0.0900	8.82e-02	0.018000	5.17e-01	8.95e-01
MAPK targets/ Nuclear events mediated by MAP kinases	30	7.00e-01	8.78e-01	0.0897	8.83e-02	0.015900	4.03e-01	8.81e-01
The role of Nef in HIV-1 replication and disease pathogenesis	25	7.42e-01	8.96e-01	0.0882	8.53e-02	-0.022500	4.60e-01	8.45e-01
Adenylate cyclase inhibitory pathway	14	8.55e-01	9.42e-01	0.0880	-4.31e-02	-0.076800	7.80e-01	6.19e-01
Unfolded Protein Response (UPR)	74	4.44e-01	7.40e-01	0.0875	-4.61e-02	-0.074300	4.93e-01	2.70e-01
trans-Golgi Network Vesicle Budding	58	5.23e-01	7.87e-01	0.0875	-8.36e-02	-0.025800	2.72e-01	7.34e-01
Misspliced GSK3beta mutants stabilize beta-catenin	14	8.48e-01	9.41e-01	0.0871	-3.63e-02	0.079200	8.14e-01	6.08e-01
S33 mutants of beta-catenin aren't phosphorylated	14	8.48e-01	9.41e-01	0.0871	-3.63e-02	0.079200	8.14e-01	6.08e-01
S37 mutants of beta-catenin aren't phosphorylated	14	8.48e-01	9.41e-01	0.0871	-3.63e-02	0.079200	8.14e-01	6.08e-01
S45 mutants of beta-catenin aren't phosphorylated	14	8.48e-01	9.41e-01	0.0871	-3.63e-02	0.079200	8.14e-01	6.08e-01
T41 mutants of beta-catenin aren't phosphorylated	14	8.48e-01	9.41e-01	0.0871	-3.63e-02	0.079200	8.14e-01	6.08e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	14	8.48e-01	9.41e-01	0.0871	-3.63e-02	0.079200	8.14e-01	6.08e-01
TCF dependent signaling in response to WNT	134	2.36e-01	5.44e-01	0.0871	-6.07e-02	-0.062400	2.26e-01	2.14e-01
Signaling by WNT	206	1.11e-01	3.53e-01	0.0868	-7.28e-02	-0.047300	7.29e-02	2.44e-01
ABC-family proteins mediated transport	74	4.27e-01	7.31e-01	0.0864	7.94e-02	-0.034200	2.38e-01	6.12e-01
Neutrophil degranulation	334	2.32e-02	1.34e-01	0.0864	7.68e-02	-0.039600	1.66e-02	2.17e-01
HCMV Early Events	46	6.10e-01	8.29e-01	0.0863	7.58e-02	0.041300	3.74e-01	6.28e-01
Interleukin-1 signaling	79	4.04e-01	7.15e-01	0.0861	4.26e-02	-0.074800	5.13e-01	2.51e-01
Integrin cell surface interactions	50	5.88e-01	8.27e-01	0.0860	-5.02e-02	-0.069800	5.40e-01	3.94e-01
Infectious disease	501	4.95e-03	4.42e-02	0.0859	8.59e-02	0.002840	1.12e-03	9.14e-01
Bile acid and bile salt metabolism	24	7.76e-01	9.20e-01	0.0857	5.39e-02	0.066700	6.48e-01	5.72e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	21	7.87e-01	9.23e-01	0.0855	-6.44e-02	0.056300	6.10e-01	6.55e-01
Activation of BH3-only proteins	27	7.52e-01	9.02e-01	0.0852	7.95e-02	0.030800	4.75e-01	7.82e-01
FRS-mediated FGFR2 signaling	15	8.55e-01	9.42e-01	0.0852	-5.72e-02	-0.063100	7.01e-01	6.72e-01
Protein-protein interactions at synapses	60	5.12e-01	7.84e-01	0.0848	-7.18e-02	0.045300	3.37e-01	5.45e-01
Negative regulation of MET activity	17	8.26e-01	9.40e-01	0.0847	-6.45e-02	0.054900	6.45e-01	6.95e-01
Fanconi Anemia Pathway	22	7.89e-01	9.25e-01	0.0846	8.45e-02	-0.003950	4.93e-01	9.74e-01
IRS-related events triggered by IGF1R	36	6.87e-01	8.66e-01	0.0844	2.17e-02	0.081500	8.22e-01	3.98e-01
PI-3K cascade:FGFR2	14	8.57e-01	9.42e-01	0.0842	-3.62e-02	0.076000	8.15e-01	6.22e-01
Interleukin-15 signaling	13	8.70e-01	9.48e-01	0.0842	8.38e-02	-0.007970	6.01e-01	9.60e-01
Signaling by GPCR	407	1.49e-02	9.88e-02	0.0838	-8.28e-02	0.013200	4.47e-03	6.51e-01
Platelet sensitization by LDL	15	8.58e-01	9.42e-01	0.0834	-2.30e-02	-0.080200	8.78e-01	5.91e-01
MHC class II antigen presentation	88	4.17e-01	7.24e-01	0.0833	4.75e-02	0.068500	4.42e-01	2.68e-01
Signaling by Interleukins	323	3.35e-02	1.68e-01	0.0831	6.43e-02	-0.052700	4.86e-02	1.06e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	11	8.88e-01	9.58e-01	0.0830	-4.88e-02	0.067200	7.79e-01	7.00e-01
Regulation of TP53 Activity through Acetylation	27	7.64e-01	9.11e-01	0.0827	-3.14e-02	-0.076500	7.78e-01	4.92e-01
eNOS activation	10	9.07e-01	9.66e-01	0.0821	6.97e-02	0.043400	7.03e-01	8.12e-01
Phospholipid metabolism	162	1.97e-01	4.89e-01	0.0821	-8.20e-02	0.003200	7.25e-02	9.44e-01
Signaling by NODAL	12	8.88e-01	9.58e-01	0.0818	-1.20e-02	-0.080900	9.43e-01	6.28e-01
Fatty acid metabolism	122	2.86e-01	5.99e-01	0.0814	6.11e-02	-0.053700	2.45e-01	3.07e-01
Mitochondrial translation elongation	64	5.32e-01	7.95e-01	0.0812	-1.68e-04	-0.081200	9.98e-01	2.62e-01
Nuclear Envelope Breakdown	41	6.79e-01	8.61e-01	0.0812	5.17e-02	0.062600	5.67e-01	4.88e-01
Positive epigenetic regulation of rRNA expression	36	7.10e-01	8.81e-01	0.0809	7.60e-02	0.027600	4.30e-01	7.74e-01
TP53 Regulates Metabolic Genes	70	5.03e-01	7.82e-01	0.0806	-7.98e-02	0.011600	2.49e-01	8.67e-01
Glycolysis	54	5.97e-01	8.29e-01	0.0801	-7.99e-02	-0.006180	3.10e-01	9.37e-01
NOD1/2 Signaling Pathway	27	7.63e-01	9.11e-01	0.0801	-6.13e-02	0.051600	5.82e-01	6.43e-01
PI Metabolism	75	4.98e-01	7.76e-01	0.0798	2.03e-02	0.077100	7.62e-01	2.49e-01
Signaling by VEGF	94	4.21e-01	7.28e-01	0.0796	2.31e-02	0.076100	7.00e-01	2.03e-01
Negative regulation of the PI3K/AKT network	86	4.53e-01	7.50e-01	0.0795	2.21e-02	0.076300	7.24e-01	2.22e-01
VEGFA-VEGFR2 Pathway	88	4.53e-01	7.50e-01	0.0791	3.89e-02	0.068900	5.29e-01	2.65e-01
PKA-mediated phosphorylation of CREB	18	8.39e-01	9.41e-01	0.0790	-6.50e-02	0.045000	6.33e-01	7.41e-01
Long-term potentiation	18	8.44e-01	9.41e-01	0.0788	-7.82e-02	0.009220	5.66e-01	9.46e-01
Innate Immune System	698	2.08e-03	2.18e-02	0.0784	7.64e-02	-0.017700	7.01e-04	4.32e-01
Interleukin-20 family signaling	15	8.66e-01	9.46e-01	0.0783	-4.45e-02	0.064400	7.66e-01	6.66e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	23	8.09e-01	9.36e-01	0.0780	-8.17e-03	0.077600	9.46e-01	5.20e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	22	8.25e-01	9.40e-01	0.0778	3.51e-02	0.069400	7.76e-01	5.73e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	22	8.25e-01	9.40e-01	0.0778	3.51e-02	0.069400	7.76e-01	5.73e-01
G alpha (q) signalling events	117	3.50e-01	6.70e-01	0.0773	-7.69e-02	0.008380	1.52e-01	8.76e-01
Fatty acyl-CoA biosynthesis	22	8.19e-01	9.40e-01	0.0770	-7.43e-02	0.020100	5.46e-01	8.70e-01
Synthesis of PIPs at the plasma membrane	51	6.47e-01	8.46e-01	0.0768	6.90e-02	0.033700	3.95e-01	6.77e-01
Transmission across Chemical Synapses	158	2.53e-01	5.62e-01	0.0764	-7.61e-02	0.005750	9.97e-02	9.01e-01
Synthesis of IP2, IP, and Ins in the cytosol	14	8.85e-01	9.58e-01	0.0762	-7.61e-02	0.003710	6.22e-01	9.81e-01
GPCR downstream signalling	376	4.07e-02	1.91e-01	0.0756	-7.22e-02	0.022600	1.71e-02	4.56e-01
Signaling by cytosolic FGFR1 fusion mutants	18	8.54e-01	9.42e-01	0.0754	-2.57e-02	0.070900	8.51e-01	6.03e-01
Hyaluronan metabolism	13	8.95e-01	9.59e-01	0.0750	4.88e-03	-0.074900	9.76e-01	6.40e-01
SUMOylation of SUMOylation proteins	23	8.29e-01	9.40e-01	0.0749	6.78e-02	0.032000	5.74e-01	7.91e-01
Metabolism	1447	2.28e-05	5.67e-04	0.0737	2.98e-02	-0.067400	6.63e-02	3.17e-05
ADORA2B mediated anti-inflammatory cytokines production	56	6.24e-01	8.32e-01	0.0737	-6.25e-02	0.039100	4.19e-01	6.13e-01
Toll Like Receptor 4 (TLR4) Cascade	107	4.10e-01	7.19e-01	0.0734	-3.95e-02	0.061900	4.81e-01	2.70e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	14	8.93e-01	9.59e-01	0.0725	2.22e-02	-0.069000	8.86e-01	6.55e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	8.28e-01	9.40e-01	0.0724	-5.53e-02	0.046800	6.46e-01	6.98e-01
SUMOylation of RNA binding proteins	36	7.66e-01	9.12e-01	0.0719	4.83e-02	0.053300	6.16e-01	5.81e-01
SUMOylation of ubiquitinylation proteins	28	8.13e-01	9.37e-01	0.0715	6.44e-02	0.031100	5.55e-01	7.76e-01
Signalling to RAS	19	8.61e-01	9.44e-01	0.0714	6.50e-02	-0.029400	6.24e-01	8.24e-01
MET activates RAS signaling	10	9.26e-01	9.70e-01	0.0714	-6.84e-04	-0.071400	9.97e-01	6.96e-01
Transcriptional Regulation by TP53	295	1.05e-01	3.46e-01	0.0709	5.94e-02	-0.038800	8.11e-02	2.55e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	22	8.51e-01	9.41e-01	0.0708	-2.26e-02	-0.067100	8.54e-01	5.86e-01
Signaling by MET	58	6.38e-01	8.42e-01	0.0707	3.55e-02	-0.061100	6.41e-01	4.21e-01
Interleukin-1 family signaling	104	4.60e-01	7.52e-01	0.0703	1.27e-02	-0.069200	8.23e-01	2.24e-01
Signal Transduction	1625	2.30e-05	5.67e-04	0.0699	-5.92e-02	0.037200	1.26e-04	1.58e-02
Apoptotic execution phase	38	7.59e-01	9.08e-01	0.0694	-5.73e-03	0.069200	9.51e-01	4.61e-01
Molecules associated with elastic fibres	26	8.26e-01	9.40e-01	0.0693	-1.66e-02	0.067300	8.84e-01	5.53e-01
Hedgehog 'off' state	84	5.40e-01	8.02e-01	0.0689	3.43e-02	-0.059800	5.87e-01	3.45e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	8.75e-01	9.51e-01	0.0689	4.13e-02	-0.055100	7.62e-01	6.86e-01
Signaling by FGFR3	28	8.27e-01	9.40e-01	0.0684	6.26e-02	0.027400	5.66e-01	8.02e-01
RNA Polymerase II Pre-transcription Events	62	6.49e-01	8.46e-01	0.0683	-4.11e-04	-0.068300	9.96e-01	3.53e-01
Golgi Associated Vesicle Biogenesis	46	7.31e-01	8.91e-01	0.0683	-6.50e-02	-0.021100	4.46e-01	8.05e-01
Estrogen-dependent gene expression	76	5.80e-01	8.24e-01	0.0681	-3.18e-02	0.060200	6.33e-01	3.65e-01
HDACs deacetylate histones	26	8.33e-01	9.41e-01	0.0675	6.22e-02	-0.026400	5.83e-01	8.16e-01
TNF signaling	33	8.07e-01	9.36e-01	0.0673	4.45e-02	0.050500	6.58e-01	6.16e-01
Axon guidance	396	7.62e-02	2.80e-01	0.0667	-4.81e-03	0.066500	8.71e-01	2.42e-02
Immune System	1413	2.53e-04	4.25e-03	0.0667	6.66e-02	0.003050	4.71e-05	8.52e-01
Nervous system development	414	6.63e-02	2.56e-01	0.0665	-1.71e-02	0.064300	5.53e-01	2.60e-02
mRNA Splicing - Minor Pathway	37	7.83e-01	9.23e-01	0.0663	4.26e-03	-0.066100	9.64e-01	4.87e-01
Class A/1 (Rhodopsin-like receptors)	112	4.95e-01	7.75e-01	0.0662	5.57e-02	0.035800	3.10e-01	5.13e-01
Vesicle-mediated transport	514	3.82e-02	1.83e-01	0.0661	-6.54e-02	0.009680	1.21e-02	7.10e-01
Mitochondrial translation termination	64	6.53e-01	8.49e-01	0.0661	1.63e-02	-0.064100	8.22e-01	3.76e-01
Negative regulation of FGFR3 signaling	19	8.85e-01	9.58e-01	0.0659	1.47e-02	0.064300	9.12e-01	6.28e-01
MyD88-independent TLR4 cascade	83	5.72e-01	8.24e-01	0.0659	-5.34e-02	0.038600	4.01e-01	5.44e-01
TRIF(TICAM1)-mediated TLR4 signaling	83	5.72e-01	8.24e-01	0.0659	-5.34e-02	0.038600	4.01e-01	5.44e-01
COPI-dependent Golgi-to-ER retrograde traffic	69	6.30e-01	8.36e-01	0.0656	5.47e-02	-0.036400	4.33e-01	6.02e-01
GPVI-mediated activation cascade	27	8.46e-01	9.41e-01	0.0656	5.59e-02	0.034300	6.15e-01	7.58e-01
Phase 0 - rapid depolarisation	31	8.15e-01	9.37e-01	0.0654	-2.74e-02	0.059400	7.92e-01	5.67e-01
Metabolism of water-soluble vitamins and cofactors	90	5.76e-01	8.24e-01	0.0654	-3.60e-02	-0.054600	5.55e-01	3.72e-01
Epigenetic regulation of gene expression	70	6.29e-01	8.35e-01	0.0653	4.16e-02	-0.050400	5.48e-01	4.67e-01
IRS-mediated signalling	33	8.13e-01	9.37e-01	0.0652	1.20e-02	0.064100	9.05e-01	5.24e-01
Transcriptional regulation by small RNAs	33	8.10e-01	9.36e-01	0.0648	6.36e-02	-0.012400	5.27e-01	9.02e-01
Activation of HOX genes during differentiation	42	7.63e-01	9.11e-01	0.0643	3.27e-02	-0.055400	7.14e-01	5.35e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	42	7.63e-01	9.11e-01	0.0643	3.27e-02	-0.055400	7.14e-01	5.35e-01
Repression of WNT target genes	12	9.33e-01	9.70e-01	0.0633	-4.73e-02	-0.042100	7.77e-01	8.01e-01
FGFR1 mutant receptor activation	23	8.75e-01	9.51e-01	0.0631	2.64e-02	0.057300	8.27e-01	6.34e-01
Toll-like Receptor Cascades	122	4.87e-01	7.71e-01	0.0626	-9.09e-03	0.062000	8.63e-01	2.38e-01
DNA Damage Recognition in GG-NER	27	8.51e-01	9.41e-01	0.0624	6.03e-02	-0.016100	5.88e-01	8.85e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	81	6.13e-01	8.29e-01	0.0623	-3.95e-02	0.048200	5.39e-01	4.54e-01
Toll Like Receptor 2 (TLR2) Cascade	81	6.13e-01	8.29e-01	0.0623	-3.95e-02	0.048200	5.39e-01	4.54e-01
Toll Like Receptor TLR1:TLR2 Cascade	81	6.13e-01	8.29e-01	0.0623	-3.95e-02	0.048200	5.39e-01	4.54e-01
Toll Like Receptor TLR6:TLR2 Cascade	81	6.13e-01	8.29e-01	0.0623	-3.95e-02	0.048200	5.39e-01	4.54e-01
Prefoldin mediated transfer of substrate to CCT/TriC	19	8.96e-01	9.59e-01	0.0622	4.33e-03	0.062100	9.74e-01	6.40e-01
Mitochondrial translation	70	6.75e-01	8.60e-01	0.0620	-1.68e-02	-0.059700	8.08e-01	3.89e-01
MyD88 cascade initiated on plasma membrane	70	6.71e-01	8.57e-01	0.0618	-6.18e-02	-0.001210	3.72e-01	9.86e-01
Toll Like Receptor 10 (TLR10) Cascade	70	6.71e-01	8.57e-01	0.0618	-6.18e-02	-0.001210	3.72e-01	9.86e-01
Toll Like Receptor 5 (TLR5) Cascade	70	6.71e-01	8.57e-01	0.0618	-6.18e-02	-0.001210	3.72e-01	9.86e-01
Toll Like Receptor 9 (TLR9) Cascade	81	6.20e-01	8.30e-01	0.0616	-4.02e-02	0.046700	5.33e-01	4.68e-01
Chromatin modifying enzymes	168	3.74e-01	6.89e-01	0.0616	-3.99e-02	0.047000	3.74e-01	2.95e-01
Chromatin organization	168	3.74e-01	6.89e-01	0.0616	-3.99e-02	0.047000	3.74e-01	2.95e-01
LDL clearance	15	9.21e-01	9.69e-01	0.0616	-5.28e-02	-0.031700	7.24e-01	8.32e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	26	8.63e-01	9.45e-01	0.0615	5.00e-04	-0.061500	9.96e-01	5.87e-01
RNA Polymerase II Transcription	892	1.19e-02	8.34e-02	0.0611	4.93e-02	0.036000	1.42e-02	7.34e-02
Regulation of TP53 Activity	135	4.66e-01	7.54e-01	0.0609	5.69e-02	-0.021700	2.55e-01	6.64e-01
SLC transporter disorders	63	7.16e-01	8.83e-01	0.0607	5.19e-02	0.031500	4.77e-01	6.66e-01
RMTs methylate histone arginines	29	8.58e-01	9.42e-01	0.0605	-4.91e-02	-0.035500	6.48e-01	7.41e-01
Metabolism of steroids	103	5.84e-01	8.24e-01	0.0605	-4.57e-02	-0.039700	4.24e-01	4.87e-01
Cytokine Signaling in Immune system	599	3.94e-02	1.87e-01	0.0605	5.42e-02	-0.026900	2.52e-02	2.67e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	77	6.55e-01	8.50e-01	0.0600	-5.73e-02	0.017700	3.85e-01	7.89e-01
Neurotransmitter receptors and postsynaptic signal transmission	120	5.22e-01	7.87e-01	0.0599	-5.87e-02	0.011900	2.68e-01	8.22e-01
Gene Silencing by RNA	47	7.78e-01	9.21e-01	0.0594	-6.27e-03	0.059100	9.41e-01	4.84e-01
TGF-beta receptor signaling activates SMADs	22	8.90e-01	9.59e-01	0.0594	5.91e-02	-0.005060	6.31e-01	9.67e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	17	9.12e-01	9.67e-01	0.0588	3.51e-02	-0.047200	8.02e-01	7.36e-01
Neurodegenerative Diseases	17	9.12e-01	9.67e-01	0.0588	3.51e-02	-0.047200	8.02e-01	7.36e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	81	6.66e-01	8.57e-01	0.0587	1.68e-02	0.056300	7.95e-01	3.82e-01
Gap junction trafficking and regulation	16	9.22e-01	9.69e-01	0.0586	5.51e-03	0.058300	9.70e-01	6.86e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	9.09e-01	9.66e-01	0.0584	4.44e-02	-0.037900	7.44e-01	7.81e-01
SUMOylation of transcription factors	14	9.33e-01	9.70e-01	0.0582	5.61e-02	0.015400	7.16e-01	9.20e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	8.96e-01	9.59e-01	0.0580	4.37e-02	-0.038100	7.29e-01	7.63e-01
Gene expression (Transcription)	990	1.24e-02	8.63e-02	0.0579	4.80e-02	0.032400	1.23e-02	9.07e-02
Generic Transcription Pathway	796	2.80e-02	1.51e-01	0.0577	4.91e-02	0.030400	2.05e-02	1.52e-01
Depolymerisation of the Nuclear Lamina	14	9.35e-01	9.70e-01	0.0576	-2.85e-02	-0.050100	8.54e-01	7.46e-01
VEGFR2 mediated cell proliferation	19	9.13e-01	9.67e-01	0.0576	-2.62e-02	-0.051300	8.44e-01	6.99e-01
TNFR1-induced proapoptotic signaling	13	9.36e-01	9.70e-01	0.0572	-3.32e-02	0.046600	8.36e-01	7.71e-01
Transcriptional regulation by RUNX3	81	6.78e-01	8.61e-01	0.0572	5.62e-02	0.010700	3.83e-01	8.68e-01
Clathrin-mediated endocytosis	106	6.02e-01	8.29e-01	0.0568	-5.68e-02	-0.001570	3.13e-01	9.78e-01
HIV Transcription Initiation	37	8.39e-01	9.41e-01	0.0568	-1.16e-02	-0.055600	9.03e-01	5.59e-01
RNA Polymerase II HIV Promoter Escape	37	8.39e-01	9.41e-01	0.0568	-1.16e-02	-0.055600	9.03e-01	5.59e-01
RNA Polymerase II Promoter Escape	37	8.39e-01	9.41e-01	0.0568	-1.16e-02	-0.055600	9.03e-01	5.59e-01
RNA Polymerase II Transcription Initiation	37	8.39e-01	9.41e-01	0.0568	-1.16e-02	-0.055600	9.03e-01	5.59e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	37	8.39e-01	9.41e-01	0.0568	-1.16e-02	-0.055600	9.03e-01	5.59e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	37	8.39e-01	9.41e-01	0.0568	-1.16e-02	-0.055600	9.03e-01	5.59e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	11	9.50e-01	9.78e-01	0.0567	3.66e-02	0.043300	8.33e-01	8.04e-01
Ovarian tumor domain proteases	28	8.75e-01	9.51e-01	0.0564	-2.24e-03	0.056300	9.84e-01	6.06e-01
Transcriptional regulation by RUNX1	146	5.12e-01	7.84e-01	0.0559	5.54e-02	0.007580	2.49e-01	8.75e-01
Retinoid metabolism and transport	25	8.92e-01	9.59e-01	0.0559	-5.42e-02	-0.013400	6.39e-01	9.08e-01
Leishmania infection	158	4.85e-01	7.71e-01	0.0557	3.63e-03	0.055600	9.37e-01	2.29e-01
Downstream signal transduction	28	8.74e-01	9.51e-01	0.0557	-2.61e-02	0.049200	8.11e-01	6.53e-01
HCMV Infection	64	7.39e-01	8.94e-01	0.0557	5.40e-02	-0.013400	4.55e-01	8.53e-01
Neurotransmitter release cycle	28	8.80e-01	9.54e-01	0.0553	-5.94e-03	-0.055000	9.57e-01	6.14e-01
Anti-inflammatory response favouring Leishmania parasite infection	89	6.65e-01	8.57e-01	0.0553	-5.53e-02	0.002360	3.68e-01	9.69e-01
Leishmania parasite growth and survival	89	6.65e-01	8.57e-01	0.0553	-5.53e-02	0.002360	3.68e-01	9.69e-01
Budding and maturation of HIV virion	19	9.17e-01	9.69e-01	0.0553	-5.49e-02	-0.006570	6.79e-01	9.61e-01
SLC-mediated transmembrane transport	155	4.91e-01	7.71e-01	0.0552	5.41e-02	-0.010600	2.46e-01	8.20e-01
ERK/MAPK targets	22	9.03e-01	9.62e-01	0.0546	4.84e-02	-0.025300	6.95e-01	8.37e-01
Cellular responses to external stimuli	368	1.98e-01	4.89e-01	0.0545	5.33e-02	-0.011800	8.16e-02	7.01e-01
HCMV Late Events	41	8.29e-01	9.40e-01	0.0542	4.23e-02	-0.034000	6.40e-01	7.07e-01
Glutamate Neurotransmitter Release Cycle	16	9.34e-01	9.70e-01	0.0542	-2.76e-02	-0.046600	8.48e-01	7.47e-01
PI-3K cascade:FGFR4	11	9.53e-01	9.79e-01	0.0535	1.54e-02	-0.051300	9.30e-01	7.68e-01
Cellular Senescence	108	6.20e-01	8.30e-01	0.0535	-4.01e-02	0.035400	4.73e-01	5.26e-01
Metabolism of vitamins and cofactors	135	5.82e-01	8.24e-01	0.0531	-3.31e-02	-0.041500	5.07e-01	4.06e-01
Developmental Biology	619	8.03e-02	2.91e-01	0.0530	-1.25e-02	0.051500	6.01e-01	3.08e-02
Opioid Signalling	70	7.39e-01	8.94e-01	0.0527	-2.98e-02	0.043500	6.67e-01	5.30e-01
Membrane Trafficking	487	1.38e-01	4.04e-01	0.0527	-5.17e-02	0.010300	5.32e-02	6.99e-01
Signaling by PDGFR in disease	19	9.27e-01	9.70e-01	0.0526	3.11e-02	0.042400	8.14e-01	7.49e-01
Syndecan interactions	17	9.32e-01	9.70e-01	0.0526	-5.01e-03	-0.052300	9.71e-01	7.09e-01
Metabolism of fat-soluble vitamins	27	8.96e-01	9.59e-01	0.0526	-5.08e-02	-0.013500	6.48e-01	9.03e-01
MyD88 dependent cascade initiated on endosome	78	7.18e-01	8.83e-01	0.0524	-4.60e-02	0.025100	4.83e-01	7.02e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	78	7.18e-01	8.83e-01	0.0524	-4.60e-02	0.025100	4.83e-01	7.02e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	37	8.64e-01	9.46e-01	0.0523	-2.78e-02	-0.044300	7.70e-01	6.41e-01
Signaling by NTRK2 (TRKB)	21	9.17e-01	9.69e-01	0.0523	8.16e-03	-0.051600	9.48e-01	6.82e-01
Diseases of programmed cell death	18	9.26e-01	9.70e-01	0.0521	3.31e-02	-0.040200	8.08e-01	7.68e-01
FCERI mediated MAPK activation	27	8.96e-01	9.59e-01	0.0513	4.68e-02	-0.021000	6.74e-01	8.50e-01
Cellular responses to stress	363	2.48e-01	5.55e-01	0.0511	5.07e-02	-0.006580	9.96e-02	8.31e-01
MAPK family signaling cascades	251	3.96e-01	7.13e-01	0.0511	-2.90e-02	-0.042100	4.31e-01	2.54e-01
SARS-CoV Infections	67	7.77e-01	9.21e-01	0.0509	1.79e-02	0.047600	8.01e-01	5.01e-01
RAF-independent MAPK1/3 activation	21	9.19e-01	9.69e-01	0.0508	2.36e-02	-0.045000	8.52e-01	7.21e-01
Viral Messenger RNA Synthesis	29	8.96e-01	9.59e-01	0.0507	4.98e-02	0.009560	6.42e-01	9.29e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	48	8.29e-01	9.40e-01	0.0502	-2.60e-02	0.043000	7.55e-01	6.07e-01
PI3K/AKT Signaling in Cancer	81	7.50e-01	9.02e-01	0.0497	2.45e-02	0.043200	7.03e-01	5.02e-01
Prolonged ERK activation events	14	9.50e-01	9.78e-01	0.0496	-3.05e-03	-0.049500	9.84e-01	7.49e-01
Negative regulation of FGFR4 signaling	18	9.33e-01	9.70e-01	0.0495	-3.66e-02	0.033400	7.88e-01	8.06e-01
Amino acids regulate mTORC1	42	8.66e-01	9.46e-01	0.0489	-3.65e-02	-0.032500	6.82e-01	7.16e-01
Signaling by Insulin receptor	54	8.30e-01	9.40e-01	0.0488	-2.03e-02	-0.044400	7.96e-01	5.73e-01
Protein folding	73	7.79e-01	9.21e-01	0.0486	-1.82e-02	-0.045000	7.88e-01	5.07e-01
Cargo concentration in the ER	20	9.34e-01	9.70e-01	0.0485	-1.63e-02	-0.045700	9.00e-01	7.23e-01
RHO GTPases activate PAKs	21	9.32e-01	9.70e-01	0.0485	3.66e-02	0.031800	7.72e-01	8.01e-01
Insulin receptor signalling cascade	38	8.80e-01	9.54e-01	0.0481	1.86e-02	0.044400	8.43e-01	6.36e-01
RNA polymerase II transcribes snRNA genes	58	8.22e-01	9.40e-01	0.0481	-4.63e-02	-0.013000	5.43e-01	8.64e-01
PPARA activates gene expression	100	7.22e-01	8.84e-01	0.0477	2.38e-02	0.041300	6.82e-01	4.76e-01
Transport of small molecules	463	2.41e-01	5.45e-01	0.0472	-3.35e-02	-0.033200	2.21e-01	2.25e-01
Metabolic disorders of biological oxidation enzymes	18	9.45e-01	9.76e-01	0.0460	4.52e-02	0.008790	7.40e-01	9.49e-01
Acyl chain remodelling of PS	13	9.60e-01	9.83e-01	0.0450	-3.93e-02	0.021900	8.06e-01	8.91e-01
TNFR1-induced NFkappaB signaling pathway	24	9.34e-01	9.70e-01	0.0446	2.40e-02	0.037600	8.38e-01	7.50e-01
Regulation of lipid metabolism by PPARalpha	102	7.50e-01	9.02e-01	0.0444	2.25e-02	0.038300	6.96e-01	5.05e-01
Tie2 Signaling	15	9.56e-01	9.81e-01	0.0442	1.67e-02	-0.041000	9.11e-01	7.84e-01
Endogenous sterols	18	9.49e-01	9.77e-01	0.0433	-3.29e-02	0.028200	8.09e-01	8.36e-01
Signaling by Erythropoietin	23	9.41e-01	9.72e-01	0.0430	2.79e-02	0.032800	8.17e-01	7.86e-01
Diseases of signal transduction by growth factor receptors and second messengers	308	4.21e-01	7.28e-01	0.0430	-3.40e-02	0.026200	3.08e-01	4.31e-01
Signal amplification	24	9.38e-01	9.71e-01	0.0427	-1.16e-02	-0.041100	9.22e-01	7.28e-01
Plasma lipoprotein clearance	24	9.39e-01	9.71e-01	0.0425	-3.89e-02	-0.017100	7.41e-01	8.85e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	153	6.69e-01	8.57e-01	0.0417	-1.08e-02	0.040200	8.19e-01	3.92e-01
Signaling by ERBB4	39	9.11e-01	9.67e-01	0.0407	-3.52e-02	-0.020500	7.04e-01	8.25e-01
Rab regulation of trafficking	104	7.82e-01	9.23e-01	0.0403	-1.26e-02	-0.038300	8.24e-01	5.01e-01
Signaling by FGFR2 IIIa TM	12	9.71e-01	9.87e-01	0.0400	-3.57e-02	0.017900	8.30e-01	9.15e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	8.88e-01	9.58e-01	0.0400	3.54e-03	0.039800	9.65e-01	6.27e-01
Signaling by Non-Receptor Tyrosine Kinases	43	8.99e-01	9.60e-01	0.0399	-2.05e-02	0.034200	8.17e-01	6.98e-01
Signaling by PTK6	43	8.99e-01	9.60e-01	0.0399	-2.05e-02	0.034200	8.17e-01	6.98e-01
Signaling by FGFR in disease	45	9.00e-01	9.60e-01	0.0397	5.42e-03	0.039300	9.50e-01	6.48e-01
MAPK1/MAPK3 signaling	218	6.12e-01	8.29e-01	0.0395	-9.07e-03	-0.038400	8.18e-01	3.30e-01
Apoptosis	137	7.26e-01	8.88e-01	0.0394	3.87e-02	-0.007160	4.36e-01	8.85e-01
RAB GEFs exchange GTP for GDP on RABs	78	8.35e-01	9.41e-01	0.0393	3.93e-02	-0.001150	5.50e-01	9.86e-01
Programmed Cell Death	140	7.22e-01	8.84e-01	0.0392	3.82e-02	-0.008800	4.36e-01	8.58e-01
Platelet activation, signaling and aggregation	197	6.48e-01	8.46e-01	0.0392	-1.30e-02	-0.036900	7.54e-01	3.73e-01
Signaling by NOTCH	147	7.13e-01	8.83e-01	0.0391	-3.84e-02	0.007350	4.23e-01	8.78e-01
RAF/MAP kinase cascade	213	6.36e-01	8.40e-01	0.0385	-1.37e-02	-0.036000	7.31e-01	3.67e-01
Cilium Assembly	152	7.17e-01	8.83e-01	0.0383	-2.66e-03	0.038200	9.55e-01	4.18e-01
Intrinsic Pathway for Apoptosis	42	9.10e-01	9.67e-01	0.0379	2.99e-02	-0.023200	7.37e-01	7.95e-01
FOXO-mediated transcription	51	9.00e-01	9.60e-01	0.0374	5.39e-03	0.037000	9.47e-01	6.48e-01
Metabolism of lipids	527	3.64e-01	6.83e-01	0.0371	-3.44e-02	-0.014000	1.81e-01	5.88e-01
Metabolism of cofactors	19	9.61e-01	9.83e-01	0.0371	3.70e-02	-0.003090	7.80e-01	9.81e-01
Platelet degranulation	96	8.27e-01	9.40e-01	0.0370	3.43e-02	0.013700	5.62e-01	8.16e-01
Post-translational protein modification	1002	1.71e-01	4.58e-01	0.0363	3.45e-02	0.011000	7.02e-02	5.63e-01
tRNA processing	85	8.55e-01	9.42e-01	0.0353	3.51e-02	0.004020	5.76e-01	9.49e-01
Response to elevated platelet cytosolic Ca2+	100	8.32e-01	9.41e-01	0.0350	3.49e-02	-0.002770	5.47e-01	9.62e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	21	9.62e-01	9.83e-01	0.0350	1.30e-03	-0.035000	9.92e-01	7.81e-01
Metabolism of proteins	1374	1.08e-01	3.53e-01	0.0350	3.49e-02	0.000920	3.51e-02	9.56e-01
FLT3 Signaling	226	6.85e-01	8.66e-01	0.0344	-2.73e-02	-0.020900	4.81e-01	5.90e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	74	8.77e-01	9.52e-01	0.0341	-8.96e-03	0.032900	8.94e-01	6.25e-01
Toll Like Receptor 3 (TLR3) Cascade	79	8.68e-01	9.47e-01	0.0340	-2.63e-02	0.021400	6.86e-01	7.42e-01
PTEN Regulation	118	8.10e-01	9.36e-01	0.0339	2.60e-02	-0.021800	6.27e-01	6.83e-01
Amyloid fiber formation	32	9.47e-01	9.77e-01	0.0339	-6.08e-03	-0.033400	9.53e-01	7.44e-01
HIV Life Cycle	108	8.38e-01	9.41e-01	0.0332	3.32e-02	0.001970	5.52e-01	9.72e-01
Cytosolic sensors of pathogen-associated DNA	48	9.22e-01	9.69e-01	0.0330	2.03e-02	-0.026100	8.08e-01	7.55e-01
Basigin interactions	20	9.67e-01	9.86e-01	0.0327	-1.52e-02	0.028900	9.06e-01	8.23e-01
Interleukin-2 signaling	10	9.84e-01	9.90e-01	0.0325	-8.87e-03	0.031300	9.61e-01	8.64e-01
Senescence-Associated Secretory Phenotype (SASP)	39	9.38e-01	9.71e-01	0.0325	1.29e-02	-0.029800	8.89e-01	7.48e-01
Gap junction trafficking	14	9.78e-01	9.89e-01	0.0324	-1.11e-02	0.030400	9.42e-01	8.44e-01
G alpha (i) signalling events	188	7.46e-01	8.99e-01	0.0321	-3.06e-02	0.009450	4.70e-01	8.24e-01
Signaling by Hedgehog	111	8.49e-01	9.41e-01	0.0320	-1.29e-02	-0.029300	8.15e-01	5.95e-01
Signaling by FGFR1 in disease	30	9.55e-01	9.81e-01	0.0318	3.12e-02	-0.005860	7.68e-01	9.56e-01
Transcription of the HIV genome	53	9.25e-01	9.70e-01	0.0313	4.43e-03	-0.031000	9.56e-01	6.97e-01
Signal regulatory protein family interactions	13	9.81e-01	9.89e-01	0.0311	3.00e-02	-0.007990	8.51e-01	9.60e-01
ESR-mediated signaling	133	8.22e-01	9.40e-01	0.0309	-1.86e-02	0.024700	7.12e-01	6.24e-01
AMER1 mutants destabilize the destruction complex	13	9.82e-01	9.89e-01	0.0309	1.98e-02	0.023700	9.02e-01	8.82e-01
APC truncation mutants have impaired AXIN binding	13	9.82e-01	9.89e-01	0.0309	1.98e-02	0.023700	9.02e-01	8.82e-01
AXIN missense mutants destabilize the destruction complex	13	9.82e-01	9.89e-01	0.0309	1.98e-02	0.023700	9.02e-01	8.82e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	13	9.82e-01	9.89e-01	0.0309	1.98e-02	0.023700	9.02e-01	8.82e-01
Truncations of AMER1 destabilize the destruction complex	13	9.82e-01	9.89e-01	0.0309	1.98e-02	0.023700	9.02e-01	8.82e-01
truncated APC mutants destabilize the destruction complex	13	9.82e-01	9.89e-01	0.0309	1.98e-02	0.023700	9.02e-01	8.82e-01
Signaling by FGFR4	27	9.63e-01	9.83e-01	0.0307	3.02e-02	0.005440	7.86e-01	9.61e-01
Disease	1017	2.89e-01	6.03e-01	0.0298	-4.16e-05	0.029800	9.98e-01	1.16e-01
Interleukin-17 signaling	59	9.23e-01	9.69e-01	0.0298	-2.75e-02	0.011400	7.15e-01	8.80e-01
Extra-nuclear estrogen signaling	61	9.21e-01	9.69e-01	0.0298	4.96e-03	-0.029300	9.47e-01	6.92e-01
VLDLR internalisation and degradation	11	9.86e-01	9.91e-01	0.0297	1.75e-02	0.024000	9.20e-01	8.90e-01
L1CAM interactions	86	8.92e-01	9.59e-01	0.0296	-2.89e-02	0.006200	6.43e-01	9.21e-01
O-linked glycosylation of mucins	31	9.62e-01	9.83e-01	0.0293	-2.51e-02	-0.015200	8.09e-01	8.83e-01
Signaling by Nuclear Receptors	185	7.95e-01	9.26e-01	0.0288	5.09e-03	-0.028300	9.05e-01	5.08e-01
GPCR ligand binding	155	8.43e-01	9.41e-01	0.0276	-2.68e-02	-0.006430	5.66e-01	8.91e-01
HATs acetylate histones	64	9.34e-01	9.70e-01	0.0269	-2.68e-02	-0.002100	7.11e-01	9.77e-01
Peptide ligand-binding receptors	65	9.33e-01	9.70e-01	0.0264	-8.80e-03	0.024900	9.02e-01	7.29e-01
Signaling by Rho GTPases	315	7.38e-01	8.94e-01	0.0263	1.76e-02	0.019500	5.93e-01	5.55e-01
SUMOylation of transcription cofactors	36	9.70e-01	9.87e-01	0.0240	-2.27e-02	-0.007860	8.14e-01	9.35e-01
Processing of SMDT1	11	9.91e-01	9.94e-01	0.0230	-7.07e-03	-0.021900	9.68e-01	9.00e-01
PIP3 activates AKT signaling	217	8.51e-01	9.41e-01	0.0229	1.94e-02	0.012200	6.24e-01	7.57e-01
Signaling by FGFR2 in disease	27	9.80e-01	9.89e-01	0.0224	-5.14e-03	-0.021800	9.63e-01	8.45e-01
SHC-mediated cascade:FGFR2	14	9.90e-01	9.94e-01	0.0219	-4.46e-03	-0.021400	9.77e-01	8.90e-01
Chaperonin-mediated protein folding	67	9.62e-01	9.83e-01	0.0197	-2.56e-03	-0.019500	9.71e-01	7.83e-01
TP53 Regulates Transcription of Cell Death Genes	34	9.80e-01	9.89e-01	0.0195	1.91e-02	-0.004010	8.47e-01	9.68e-01
FCGR3A-mediated IL10 synthesis	38	9.85e-01	9.90e-01	0.0169	-1.18e-02	-0.012100	9.00e-01	8.97e-01
Late Phase of HIV Life Cycle	99	9.66e-01	9.86e-01	0.0149	1.10e-02	-0.010000	8.50e-01	8.63e-01
Intracellular signaling by second messengers	252	9.22e-01	9.69e-01	0.0145	-1.11e-02	0.009320	7.62e-01	8.00e-01
Golgi-to-ER retrograde transport	98	9.69e-01	9.87e-01	0.0145	1.24e-02	-0.007450	8.32e-01	8.99e-01
Interleukin-4 and Interleukin-13 signaling	82	9.77e-01	9.89e-01	0.0141	-4.97e-03	-0.013200	9.38e-01	8.37e-01
Frs2-mediated activation	12	9.96e-01	9.97e-01	0.0139	-4.79e-03	0.013000	9.77e-01	9.38e-01
Downstream signaling of activated FGFR2	20	9.95e-01	9.97e-01	0.0126	-9.54e-03	0.008260	9.41e-01	9.49e-01
Hemostasis	426	9.17e-01	9.69e-01	0.0121	-1.07e-02	-0.005640	7.08e-01	8.43e-01
MAP kinase activation	56	9.91e-01	9.94e-01	0.0103	2.98e-03	0.009910	9.69e-01	8.98e-01
Organelle biogenesis and maintenance	219	9.79e-01	9.89e-01	0.0083	-6.81e-03	-0.004750	8.63e-01	9.04e-01
Aggrephagy	14	9.99e-01	9.99e-01	0.0070	3.16e-03	-0.006240	9.84e-01	9.68e-01

---

Detailed Gene set reports

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

metric	value
setSize	10
pMANOVA	0.000425
p.adjustMANOVA	0.0063
s.dist	0.724
s.rna	0.714
s.meth	0.12
p.rna	9.25e-05
p.meth	0.511

Top 20 genes

Gene	rna	meth
RAD21	5770	5201
SMC1A	5006	5522
STAG1	4886	4574
CDCA5	4872	1705
ESCO1	4587	666

Click HERE to show all gene set members

All member genes

	rna	meth
CDCA5	4872	1705
ESCO1	4587	666
ESCO2	4786	-3133
PDS5A	-2549	549
PDS5B	5127	-853
RAD21	5770	5201
SMC1A	5006	5522
SMC3	4228	-1477
STAG1	4886	4574
STAG2	5520	-1637

---

---

Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis

metric	value
setSize	10
pMANOVA	0.000554
p.adjustMANOVA	0.00761
s.dist	0.715
s.rna	0.685
s.meth	0.204
p.rna	0.000176
p.meth	0.264

Top 20 genes

Gene	rna	meth
RAD21	5770	5201
SMC1A	5006	5522
KIF23	5052	5271
STAG1	4886	4574
NIPBL	3779	3705

Click HERE to show all gene set members

All member genes

	rna	meth
KIF20A	3729	-4815
KIF23	5052	5271
NIPBL	3779	3705
PDS5A	-2549	549
PDS5B	5127	-853
RAD21	5770	5201
SMC1A	5006	5522
SMC3	4228	-1477
STAG1	4886	4574
STAG2	5520	-1637

---

---

Glucuronidation

Glucuronidation

metric	value
setSize	11
pMANOVA	0.00049
p.adjustMANOVA	0.00709
s.dist	0.693
s.rna	0.56
s.meth	0.408
p.rna	0.00129
p.meth	0.019

Top 20 genes

Gene	rna	meth
UGT1A10	4368.5	5564.5
UGT1A7	4368.5	5564.5
UGT1A8	4368.5	5564.5
UGT1A9	4368.5	5564.5
UGT1A6	3432.0	4124.0
UGT3A1	5880.5	1600.5
UGT3A2	5880.5	1600.5
ABHD10	2118.0	3730.0

Click HERE to show all gene set members

All member genes

	rna	meth
ABHD10	2118.0	3730.0
SLC35D1	2853.0	-3766.0
UGDH	2002.0	-4440.0
UGP2	-3068.0	5670.0
UGT1A10	4368.5	5564.5
UGT1A6	3432.0	4124.0
UGT1A7	4368.5	5564.5
UGT1A8	4368.5	5564.5
UGT1A9	4368.5	5564.5
UGT3A1	5880.5	1600.5
UGT3A2	5880.5	1600.5

---

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Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	37
pMANOVA	2.92e-11
p.adjustMANOVA	9.17e-09
s.dist	0.654
s.rna	0.627
s.meth	-0.183
p.rna	3.97e-11
p.meth	0.0542

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
DNAJC3	4432	-4897
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
GRSF1	3590	-2421
RPS23	4486	-1473
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333

Click HERE to show all gene set members

All member genes

	rna	meth
DNAJC3	4432	-4897
FAU	2178	4979
GRSF1	3590	-2421
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	37
pMANOVA	1.12e-10
p.adjustMANOVA	2.02e-08
s.dist	0.636
s.rna	0.614
s.meth	-0.164
p.rna	1e-10
p.meth	0.0851

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
EEF1A1	4511	-2900
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333
RPL37	674	-1603

Click HERE to show all gene set members

All member genes

	rna	meth
EEF1A1	4511	-2900
EEF2	683	-231
FAU	2178	4979
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

Constitutive Signaling by NOTCH1 HD Domain Mutants

Constitutive Signaling by NOTCH1 HD Domain Mutants

metric	value
setSize	10
pMANOVA	0.00248
p.adjustMANOVA	0.0248
s.dist	0.619
s.rna	-0.46
s.meth	0.414
p.rna	0.0117
p.meth	0.0234

Top 20 genes

Gene	rna	meth
ADAM17	-5086	4551
DLL1	-5439	4045
NOTCH1	-4936	4309
NEURL1B	-1809	5119
JAG2	-4448	1319
JAG1	-2314	2150
ADAM10	-720	5394

Click HERE to show all gene set members

All member genes

	rna	meth
ADAM10	-720	5394
ADAM17	-5086	4551
DLL1	-5439	4045
DLL4	-4746	-1299
JAG1	-2314	2150
JAG2	-4448	1319
MIB1	3903	5308
MIB2	-842	-2577
NEURL1B	-1809	5119
NOTCH1	-4936	4309

---

---

Signaling by NOTCH1 HD Domain Mutants in Cancer

Signaling by NOTCH1 HD Domain Mutants in Cancer

metric	value
setSize	10
pMANOVA	0.00248
p.adjustMANOVA	0.0248
s.dist	0.619
s.rna	-0.46
s.meth	0.414
p.rna	0.0117
p.meth	0.0234

Top 20 genes

Gene	rna	meth
ADAM17	-5086	4551
DLL1	-5439	4045
NOTCH1	-4936	4309
NEURL1B	-1809	5119
JAG2	-4448	1319
JAG1	-2314	2150
ADAM10	-720	5394

Click HERE to show all gene set members

All member genes

	rna	meth
ADAM10	-720	5394
ADAM17	-5086	4551
DLL1	-5439	4045
DLL4	-4746	-1299
JAG1	-2314	2150
JAG2	-4448	1319
MIB1	3903	5308
MIB2	-842	-2577
NEURL1B	-1809	5119
NOTCH1	-4936	4309

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	40
pMANOVA	1.8e-10
p.adjustMANOVA	2.84e-08
s.dist	0.603
s.rna	0.567
s.meth	-0.206
p.rna	5.45e-10
p.meth	0.0242

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
PSTK	5197	-2248
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
RPL38	3244	-1654
SEPHS2	1082	-4764
RPS26	1768	-2630
RPL15	1902	-2225
EEFSEC	1748	-2238
SECISBP2	1084	-3063

Click HERE to show all gene set members

All member genes

	rna	meth
EEFSEC	1748	-2238
FAU	2178	4979
PSTK	5197	-2248
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507
SECISBP2	1084	-3063
SEPHS2	1082	-4764
SEPSECS	-4085	-2348

---

---

Dissolution of Fibrin Clot

Dissolution of Fibrin Clot

metric	value
setSize	10
pMANOVA	0.0062
p.adjustMANOVA	0.0531
s.dist	0.592
s.rna	0.52
s.meth	0.284
p.rna	0.00441
p.meth	0.12

Top 20 genes

Gene	rna	meth
S100A10	5485	4998
SERPINF2	5778	3700
SERPINB6	2700	6136
SERPINE2	3558	3908
SERPINB8	1995	4936
PLAU	1103	1275

Click HERE to show all gene set members

All member genes

	rna	meth
ANXA2	4454	-3566
PLAT	-3391	4919
PLAU	1103	1275
PLAUR	4393	-1953
S100A10	5485	4998
SERPINB6	2700	6136
SERPINB8	1995	4936
SERPINE1	4817	-3649
SERPINE2	3558	3908
SERPINF2	5778	3700

---

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

metric	value
setSize	26
pMANOVA	1.25e-06
p.adjustMANOVA	4.91e-05
s.dist	0.591
s.rna	0.591
s.meth	0.0136
p.rna	1.86e-07
p.meth	0.904

Top 20 genes

Gene	rna	meth
MCM6	5598	5733
POLA1	5689	4389
MCM3	3470	5749
POLE4	3954	4417
ORC3	3651	4741
DBF4	2421	3020
ORC4	1249	5675
MCM10	3772	1777
POLE2	1410	4648
GMNN	1226	1646
PRIM2	248	4044
RPA1	2329	207
CDC6	5060	9

Click HERE to show all gene set members

All member genes

	rna	meth
CDC6	5060	9
CDC7	3232	-2078
CDK2	4841	-3300
CDT1	4514	-1867
DBF4	2421	3020
GMNN	1226	1646
MCM10	3772	1777
MCM2	3949	-2945
MCM3	3470	5749
MCM4	4969	-2519
MCM5	4901	-57
MCM6	5598	5733
ORC2	4580	-3653
ORC3	3651	4741
ORC4	1249	5675
ORC5	2704	-2327
POLA1	5689	4389
POLA2	-2707	1499
POLE	4844	-2625
POLE2	1410	4648
POLE3	4843	-3859
POLE4	3954	4417
PRIM1	4883	-4606
PRIM2	248	4044
RPA1	2329	207
RPA2	5310	-4991

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	44
pMANOVA	2.07e-10
p.adjustMANOVA	2.89e-08
s.dist	0.58
s.rna	0.578
s.meth	-0.043
p.rna	3.28e-11
p.meth	0.622

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
ATF2	4920	-2439
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
ATF4	5466	-1021
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
EIF2AK4	2424	-1579
RPL28	1364	-1226

Click HERE to show all gene set members

All member genes

	rna	meth
ASNS	810	4462
ATF2	4920	-2439
ATF3	-2815	4339
ATF4	5466	-1021
CEBPB	3375	2743
CEBPG	1710	6083
EIF2AK4	2424	-1579
EIF2S2	3380	6090
FAU	2178	4979
IMPACT	1931	5372
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	40
pMANOVA	2.36e-09
p.adjustMANOVA	2.12e-07
s.dist	0.57
s.rna	0.552
s.meth	-0.14
p.rna	1.5e-09
p.meth	0.127

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
N6AMT1	3414	-4292
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
ETF1	1877	-4657
RPS23	4486	-1473
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333

Click HERE to show all gene set members

All member genes

	rna	meth
APEH	-4244	3389
ETF1	1877	-4657
FAU	2178	4979
GSPT1	1620	1260
GSPT2	-1065	5169
N6AMT1	3414	-4292
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition

metric	value
setSize	19
pMANOVA	0.000117
p.adjustMANOVA	0.0022
s.dist	0.558
s.rna	0.544
s.meth	-0.124
p.rna	4e-05
p.meth	0.35

Top 20 genes

Gene	rna	meth
WEE1	5885	-4588
CCNB1	5672	-4532
XPO1	5610	-3808
CDK2	4841	-3300
PPP2CA	3759	-2919
PPP2R1B	3770	-2725
CCNB2	4252	-2328
CDK7	1848	-4403
CCNA2	5667	-564
MNAT1	924	-1711
FOXM1	4251	-212

Click HERE to show all gene set members

All member genes

	rna	meth
CCNA2	5667	-564
CCNB1	5672	-4532
CCNB2	4252	-2328
CCNH	3180	1274
CDC25A	-142	3481
CDC25B	5471	3046
CDK1	5002	6054
CDK2	4841	-3300
CDK7	1848	-4403
FOXM1	4251	-212
LCMT1	-213	3393
MNAT1	924	-1711
PKMYT1	1087	1043
PPP2CA	3759	-2919
PPP2CB	2990	3907
PPP2R1A	-2501	2930
PPP2R1B	3770	-2725
WEE1	5885	-4588
XPO1	5610	-3808

---

---

DNA strand elongation

DNA strand elongation

metric	value
setSize	26
pMANOVA	9.02e-06
p.adjustMANOVA	0.000259
s.dist	0.544
s.rna	0.543
s.meth	-0.0364
p.rna	1.66e-06
p.meth	0.748

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
PRIM1	4883	-4606
RFC2	4698	-3562
MCM4	4969	-2519
MCM2	3949	-2945
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
GINS3	1762	-3052
DNA2	1719	-2587
POLD1	1755	-558
MCM5	4901	-57

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	1719	-2587
GINS1	4740	2599
GINS2	3315	3514
GINS3	1762	-3052
GINS4	5243	605
LIG1	4632	4263
MCM2	3949	-2945
MCM3	3470	5749
MCM4	4969	-2519
MCM5	4901	-57
MCM6	5598	5733
PCNA	5482	-2043
POLA1	5689	4389
POLA2	-2707	1499
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
PRIM1	4883	-4606
PRIM2	248	4044
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	40
pMANOVA	1.78e-08
p.adjustMANOVA	1.12e-06
s.dist	0.54
s.rna	0.525
s.meth	-0.126
p.rna	8.96e-09
p.meth	0.168

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
EEF1A1	4511	-2900
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333
RPL37	674	-1603

Click HERE to show all gene set members

All member genes

	rna	meth
EEF1A1	4511	-2900
EEF1A2	-5496	-553
EEF1D	-2215	4015
EEF1G	-2167	3715
EEF2	683	-231
FAU	2178	4979
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

Heme degradation

Heme degradation

metric	value
setSize	10
pMANOVA	0.0107
p.adjustMANOVA	0.078
s.dist	0.54
s.rna	0.29
s.meth	-0.455
p.rna	0.112
p.meth	0.0128

Top 20 genes

Gene	rna	meth
ABCG2	5098.0	-4612.0
HMOX1	4631.0	-4961.0
BLVRA	2008.0	-4385.0
ABCC2	5616.0	-268.0
GSTA1	5110.5	-184.5

Click HERE to show all gene set members

All member genes

	rna	meth
ABCC1	-723.0	-3338.0
ABCC2	5616.0	-268.0
ABCG2	5098.0	-4612.0
BLVRA	2008.0	-4385.0
BLVRB	2914.0	1022.0
GSTA1	5110.5	-184.5
GUSB	-1823.0	-118.0
HMOX1	4631.0	-4961.0
HMOX2	-3443.0	-3058.0
SLCO2B1	-1924.0	-2599.0

---

---

Recognition of DNA damage by PCNA-containing replication complex

Recognition of DNA damage by PCNA-containing replication complex

metric	value
setSize	21
pMANOVA	8.3e-05
p.adjustMANOVA	0.00168
s.dist	0.54
s.rna	0.515
s.meth	-0.16
p.rna	4.37e-05
p.meth	0.204

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
POLE3	4843	-3859
RFC2	4698	-3562
POLE	4844	-2625
PCNA	5482	-2043
RFC5	2855	-3883
USP1	4181	-2315
RBX1	3338	-2166
RFC4	1591	-3467
POLD1	1755	-558
DDB1	1352	-522
CUL4A	64	-3933

Click HERE to show all gene set members

All member genes

	rna	meth
CUL4A	64	-3933
CUL4B	4998	1375
DDB1	1352	-522
PCNA	5482	-2043
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
POLE	4844	-2625
POLE2	1410	4648
POLE3	4843	-3859
POLE4	3954	4417
RAD18	3967	5426
RBX1	3338	-2166
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991
USP1	4181	-2315

---

---

Mitophagy

Mitophagy

metric	value
setSize	19
pMANOVA	0.000322
p.adjustMANOVA	0.00513
s.dist	0.532
s.rna	-0.0205
s.meth	-0.531
p.rna	0.877
p.meth	6.07e-05

Top 20 genes

Gene	rna	meth
MFN2	-2519.0	-3317.0
TOMM40	-2464.0	-3276.0
CSNK2A1	-1910.0	-2828.0
FUNDC1	-1355.0	-3693.0
ATG5	-1461.0	-3263.0
MAP1LC3B	-2329.5	-1775.5
ULK1	-374.0	-4578.0
PGAM5	-515.0	-2793.0
PINK1	-347.0	-1903.0

Click HERE to show all gene set members

All member genes

	rna	meth
ATG5	-1461.0	-3263.0
CSNK2A1	-1910.0	-2828.0
CSNK2A2	611.0	-1809.0
FUNDC1	-1355.0	-3693.0
MAP1LC3A	3819.0	-4319.0
MAP1LC3B	-2329.5	-1775.5
MFN1	1357.0	-1107.0
MFN2	-2519.0	-3317.0
PARK2	3358.0	792.0
PGAM5	-515.0	-2793.0
PINK1	-347.0	-1903.0
SQSTM1	1089.0	-4876.0
SRC	789.0	-1681.0
TOMM22	120.0	-2046.0
TOMM40	-2464.0	-3276.0
TOMM5	-1348.0	123.0
TOMM7	1223.0	-5362.0
ULK1	-374.0	-4578.0
VDAC1	893.0	-3508.0

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	41
pMANOVA	3.76e-08
p.adjustMANOVA	1.97e-06
s.dist	0.523
s.rna	0.512
s.meth	-0.105
p.rna	1.37e-08
p.meth	0.247

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
ETF1	1877	-4657
RPS23	4486	-1473
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333
RPL37	674	-1603

Click HERE to show all gene set members

All member genes

	rna	meth
EIF4G1	-3291	-2899
ETF1	1877	-4657
FAU	2178	4979
GSPT1	1620	1260
GSPT2	-1065	5169
NCBP1	-886	6069
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507
UPF1	-2932	3893

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	46
pMANOVA	4.55e-09
p.adjustMANOVA	3.57e-07
s.dist	0.522
s.rna	0.497
s.meth	-0.157
p.rna	5.36e-09
p.meth	0.0662

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
EIF3F	2184	-2647
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333
RPL37	674	-1603

Click HERE to show all gene set members

All member genes

	rna	meth
EIF3A	-830	5092
EIF3B	-2288	-5285
EIF3D	-1349	-3832
EIF3E	4815	3218
EIF3F	2184	-2647
EIF3G	588	384
EIF3H	2870	678
EIF3I	421	-1535
EIF3K	-20	-3
EIF3L	-3582	-5434
EIF3M	3606	3235
FAU	2178	4979
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

HSF1-dependent transactivation

HSF1-dependent transactivation

metric	value
setSize	26
pMANOVA	2.72e-05
p.adjustMANOVA	0.000658
s.dist	0.518
s.rna	-0.518
s.meth	0.0151
p.rna	4.8e-06
p.meth	0.894

Top 20 genes

Gene	rna	meth
HSPA1A	-5355.5	6150.5
HSPA1B	-5355.5	6150.5
FKBP4	-5101.0	3899.0
MLST8	-4206.0	4057.0
CAMK2D	-2521.0	5678.0
COL4A6	-3334.0	3630.0
HSPH1	-5634.0	2012.0
CREBBP	-1951.0	3951.0
CAMK2B	-5720.0	1041.0
MTOR	-3177.0	1442.0
SERPINH1	-5318.0	777.0
HSP90AB1	-4942.0	690.0
EP300	-238.0	5212.0
AKT1S1	-234.0	2304.0

Click HERE to show all gene set members

All member genes

	rna	meth
AKT1S1	-234.0	2304.0
CAMK2A	748.0	-4571.0
CAMK2B	-5720.0	1041.0
CAMK2D	-2521.0	5678.0
CAMK2G	-4727.0	-4661.0
COL4A6	-3334.0	3630.0
CREBBP	-1951.0	3951.0
CRYBA4	-4716.0	-1922.0
DNAJB1	-798.0	-2161.0
DNAJB6	-3939.0	-4126.0
EP300	-238.0	5212.0
FKBP4	-5101.0	3899.0
HSBP1	-1763.0	-1709.0
HSP90AA1	-3476.0	-2340.0
HSP90AB1	-4942.0	690.0
HSPA1A	-5355.5	6150.5
HSPA1B	-5355.5	6150.5
HSPA8	-965.0	-4463.0
HSPB8	-5728.0	-2070.0
HSPH1	-5634.0	2012.0
MLST8	-4206.0	4057.0
MTOR	-3177.0	1442.0
PTGES3	4430.0	-4503.0
RPTOR	-5209.0	-2659.0
SERPINH1	-5318.0	777.0
TNFRSF21	1780.0	1143.0

---

---

Condensation of Prophase Chromosomes

Condensation of Prophase Chromosomes

metric	value
setSize	10
pMANOVA	0.02
p.adjustMANOVA	0.122
s.dist	0.518
s.rna	0.486
s.meth	0.179
p.rna	0.00785
p.meth	0.326

Top 20 genes

Gene	rna	meth
CDK1	5002	6054
NCAPH2	3199	6017
NCAPG2	5558	2495
PHF8	62	5559

Click HERE to show all gene set members

All member genes

	rna	meth
CCNB1	5672	-4532
CDK1	5002	6054
H2AFX	2774	-4682
MCPH1	-1462	3921
NCAPG2	5558	2495
NCAPH2	3199	6017
PHF8	62	5559
RB1	-1186	5692
SET	4808	-3071
SMC4	4451	-2857

---

---

Processive synthesis on the lagging strand

Processive synthesis on the lagging strand

metric	value
setSize	12
pMANOVA	0.00826
p.adjustMANOVA	0.0645
s.dist	0.516
s.rna	0.516
s.meth	-0.00771
p.rna	0.00199
p.meth	0.963

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
PRIM1	4883	-4606
PCNA	5482	-2043
DNA2	1719	-2587
POLD1	1755	-558

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	1719	-2587
LIG1	4632	4263
PCNA	5482	-2043
POLA1	5689	4389
POLA2	-2707	1499
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
PRIM1	4883	-4606
PRIM2	248	4044
RPA1	2329	207
RPA2	5310	-4991

---

---

PINK1-PRKN Mediated Mitophagy

PINK1-PRKN Mediated Mitophagy

metric	value
setSize	13
pMANOVA	0.00556
p.adjustMANOVA	0.0482
s.dist	0.515
s.rna	0.0101
s.meth	-0.515
p.rna	0.95
p.meth	0.0013

Top 20 genes

Gene	rna	meth
MAP1LC3A	3819	-4319
TOMM7	1223	-5362
SQSTM1	1089	-4876
VDAC1	893	-3508
MFN1	1357	-1107
TOMM22	120	-2046

Click HERE to show all gene set members

All member genes

	rna	meth
ATG5	-1461.0	-3263.0
MAP1LC3A	3819.0	-4319.0
MAP1LC3B	-2329.5	-1775.5
MFN1	1357.0	-1107.0
MFN2	-2519.0	-3317.0
PARK2	3358.0	792.0
PINK1	-347.0	-1903.0
SQSTM1	1089.0	-4876.0
TOMM22	120.0	-2046.0
TOMM40	-2464.0	-3276.0
TOMM5	-1348.0	123.0
TOMM7	1223.0	-5362.0
VDAC1	893.0	-3508.0

---

---

PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair

metric	value
setSize	17
pMANOVA	0.00113
p.adjustMANOVA	0.0136
s.dist	0.511
s.rna	0.497
s.meth	-0.116
p.rna	0.000385
p.meth	0.407

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
POLE3	4843	-3859
RFC2	4698	-3562
POLE	4844	-2625
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
POLD1	1755	-558

Click HERE to show all gene set members

All member genes

	rna	meth
LIG1	4632	4263
PCNA	5482	-2043
POLB	-721	72
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
POLE	4844	-2625
POLE2	1410	4648
POLE3	4843	-3859
POLE4	3954	4417
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

metric	value
setSize	10
pMANOVA	0.0231
p.adjustMANOVA	0.134
s.dist	0.505
s.rna	-0.495
s.meth	-0.101
p.rna	0.00672
p.meth	0.579

Top 20 genes

Gene	rna	meth
SOST	-3794.0	-5411.0
LRP5	-5329.5	-2358.5
WNT5A	-4679.0	-2227.0
SFRP2	-3416.0	-1941.0

Click HERE to show all gene set members

All member genes

	rna	meth
KREMEN1	-5724.0	21.0
LRP5	-5329.5	-2358.5
LRP6	-2703.0	5474.0
SFRP1	1880.0	5543.0
SFRP2	-3416.0	-1941.0
SOST	-3794.0	-5411.0
WIF1	-1562.0	2436.0
WNT4	1638.0	-4725.0
WNT5A	-4679.0	-2227.0
WNT9A	-4782.0	1363.0

---

---

Termination of translesion DNA synthesis

Termination of translesion DNA synthesis

metric	value
setSize	23
pMANOVA	0.000168
p.adjustMANOVA	0.00305
s.dist	0.497
s.rna	0.485
s.meth	-0.109
p.rna	5.63e-05
p.meth	0.365

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
UBE2L6	4714	-4264
POLE3	4843	-3859
RFC2	4698	-3562
POLE	4844	-2625
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
UBA7	1596	-2162
POLK	2356	-1123
POLD1	1755	-558
USP43	3054	-123

Click HERE to show all gene set members

All member genes

	rna	meth
PCNA	5482	-2043
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
POLE	4844	-2625
POLE2	1410	4648
POLE3	4843	-3859
POLE4	3954	4417
POLI	1323	3711
POLK	2356	-1123
REV1	5768	5885
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991
TRIM25	911	376
UBA7	1596	-2162
UBE2L6	4714	-4264
USP10	251	1381
USP43	3054	-123

---

---

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

metric	value
setSize	14
pMANOVA	0.00648
p.adjustMANOVA	0.0551
s.dist	0.497
s.rna	0.459
s.meth	0.192
p.rna	0.00298
p.meth	0.213

Top 20 genes

Gene	rna	meth
CDK1	5002	6054
RBL1	5415	5429
TFDP2	5681	3272
LIN52	5395	2218
LIN9	3039	3094
LIN54	2425	3567
RBL2	4147	1772
E2F5	1991	267

Click HERE to show all gene set members

All member genes

	rna	meth
CCNA2	5667.0	-564.0
CDK1	5002.0	6054.0
E2F1	4894.0	-699.0
E2F4	-2228.0	-259.0
E2F5	1991.0	267.0
LIN37	-3419.0	372.0
LIN52	5395.0	2218.0
LIN54	2425.0	3567.0
LIN9	3039.0	3094.0
MYBL2	4863.0	-3379.0
RBL1	5415.0	5429.0
RBL2	4147.0	1772.0
TFDP1	-4666.5	336.5
TFDP2	5681.0	3272.0

---

---

Removal of the Flap Intermediate

Removal of the Flap Intermediate

metric	value
setSize	11
pMANOVA	0.0164
p.adjustMANOVA	0.107
s.dist	0.496
s.rna	0.491
s.meth	-0.0683
p.rna	0.0048
p.meth	0.695

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
PRIM1	4883	-4606
PCNA	5482	-2043
DNA2	1719	-2587
POLD1	1755	-558

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	1719	-2587
PCNA	5482	-2043
POLA1	5689	4389
POLA2	-2707	1499
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
PRIM1	4883	-4606
PRIM2	248	4044
RPA1	2329	207
RPA2	5310	-4991

---

---

Selenoamino acid metabolism

Selenoamino acid metabolism

metric	value
setSize	53
pMANOVA	1.85e-09
p.adjustMANOVA	1.79e-07
s.dist	0.495
s.rna	0.45
s.meth	-0.206
p.rna	1.45e-08
p.meth	0.0094

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
CBS	4428	-4833
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
GNMT	4049	-3087
CTH	4249	-2909
PSTK	5197	-2248
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
PAPSS2	1288	-4378
RPL38	3244	-1654
SEPHS2	1082	-4764

Click HERE to show all gene set members

All member genes

	rna	meth
AHCY	2449.0	3155.0
AIMP2	-2988.0	-2930.0
CBS	4428.0	-4833.0
CTH	4249.0	-2909.0
EEF1E1	191.5	-1907.5
EEFSEC	1748.0	-2238.0
FAU	2178.0	4979.0
GNMT	4049.0	-3087.0
GSR	-4143.0	-3576.0
HNMT	3797.0	-246.0
NNMT	1689.0	-1284.0
PAPSS1	-983.0	3582.0
PAPSS2	1288.0	-4378.0
PSTK	5197.0	-2248.0
RPL10	5718.0	-4740.0
RPL11	4194.0	2405.0
RPL14	3458.0	-2532.0
RPL15	1902.0	-2225.0
RPL22	1607.0	2427.0
RPL22L1	5748.0	4255.0
RPL26	4617.0	1424.0
RPL28	1364.0	-1226.0
RPL3	-182.0	-4340.0
RPL30	3782.0	1289.0
RPL31	2374.0	4673.0
RPL32	4757.0	-2913.0
RPL34	3883.0	-4453.0
RPL36A	5374.0	780.0
RPL37	674.0	-1603.0
RPL37A	3795.0	-4315.0
RPL38	3244.0	-1654.0
RPL3L	4176.0	-333.0
RPL5	5000.0	741.0
RPL7	4857.0	-3120.0
RPL8	4009.0	-4579.0
RPS14	2316.0	2783.0
RPS15	2330.0	-4902.0
RPS15A	5224.0	5585.0
RPS19	3761.0	-3788.0
RPS23	4486.0	-1473.0
RPS24	5349.0	5479.0
RPS26	1768.0	-2630.0
RPS27	5413.0	-4396.0
RPS27L	5710.0	5104.0
RPS4X	5123.0	-2906.0
RPS5	4341.0	1766.0
RPS6	3537.0	-4104.0
RPS9	3320.0	1507.0
SCLY	-4762.0	2095.0
SECISBP2	1084.0	-3063.0
SEPHS2	1082.0	-4764.0
SEPSECS	-4085.0	-2348.0
TXNRD1	-1901.0	5990.0

---

---

Nucleotide-like (purinergic) receptors

Nucleotide-like (purinergic) receptors

metric	value
setSize	11
pMANOVA	0.0205
p.adjustMANOVA	0.124
s.dist	0.494
s.rna	0.254
s.meth	0.424
p.rna	0.144
p.meth	0.0149

Top 20 genes

Gene	rna	meth
P2RY12	5116	3798
P2RY1	4932	3548
ADORA1	4970	3460
P2RY10	4772	2840
P2RY13	2947	3685
P2RY14	1333	1882

Click HERE to show all gene set members

All member genes

	rna	meth
ADORA1	4970	3460
ADORA2A	-5600	5883
ADORA2B	-4054	3499
P2RY1	4932	3548
P2RY10	4772	2840
P2RY12	5116	3798
P2RY13	2947	3685
P2RY14	1333	1882
P2RY2	4028	-1081
P2RY4	-935	5322
P2RY6	-616	-1056

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	50
pMANOVA	8.78e-09
p.adjustMANOVA	6.14e-07
s.dist	0.493
s.rna	0.477
s.meth	-0.123
p.rna	5.41e-09
p.meth	0.134

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
EIF3F	2184	-2647
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333
RPL37	674	-1603

Click HERE to show all gene set members

All member genes

	rna	meth
EIF2S2	3380	6090
EIF3A	-830	5092
EIF3B	-2288	-5285
EIF3D	-1349	-3832
EIF3E	4815	3218
EIF3F	2184	-2647
EIF3G	588	384
EIF3H	2870	678
EIF3I	421	-1535
EIF3K	-20	-3
EIF3L	-3582	-5434
EIF3M	3606	3235
EIF4B	3469	3512
EIF4G1	-3291	-2899
EIF4H	2252	1194
FAU	2178	4979
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

Polo-like kinase mediated events

Polo-like kinase mediated events

metric	value
setSize	13
pMANOVA	0.00945
p.adjustMANOVA	0.0712
s.dist	0.491
s.rna	0.488
s.meth	0.0593
p.rna	0.00233
p.meth	0.712

Top 20 genes

Gene	rna	meth
CENPF	4621	5886
LIN52	5395	2218
LIN9	3039	3094
LIN54	2425	3567
PKMYT1	1087	1043

Click HERE to show all gene set members

All member genes

	rna	meth
CCNB1	5672	-4532
CCNB2	4252	-2328
CDC25A	-142	3481
CENPF	4621	5886
EP300	-238	5212
FOXM1	4251	-212
LIN37	-3419	372
LIN52	5395	2218
LIN54	2425	3567
LIN9	3039	3094
MYBL2	4863	-3379
PKMYT1	1087	1043
WEE1	5885	-4588

---

---

G1/S-Specific Transcription

G1/S-Specific Transcription

metric	value
setSize	24
pMANOVA	0.000238
p.adjustMANOVA	0.0041
s.dist	0.49
s.rna	0.425
s.meth	0.245
p.rna	0.000318
p.meth	0.0375

Top 20 genes

Gene	rna	meth
CDK1	5002.0	6054.0
RBL1	5415.0	5429.0
POLA1	5689.0	4389.0
FBXO5	4500.0	4748.0
TFDP2	5681.0	3272.0
LIN52	5395.0	2218.0
LIN9	3039.0	3094.0
LIN54	2425.0	3567.0
RBL2	4147.0	1772.0
TK1	4923.0	1201.0
DHFR	3185.5	1842.5
E2F5	1991.0	267.0
CDC6	5060.0	9.0

Click HERE to show all gene set members

All member genes

	rna	meth
CCNE1	-783.0	5758.0
CDC25A	-142.0	3481.0
CDC6	5060.0	9.0
CDK1	5002.0	6054.0
CDT1	4514.0	-1867.0
DHFR	3185.5	1842.5
E2F1	4894.0	-699.0
E2F4	-2228.0	-259.0
E2F5	1991.0	267.0
E2F6	-2059.0	632.0
FBXO5	4500.0	4748.0
LIN37	-3419.0	372.0
LIN52	5395.0	2218.0
LIN54	2425.0	3567.0
LIN9	3039.0	3094.0
PCNA	5482.0	-2043.0
POLA1	5689.0	4389.0
RBL1	5415.0	5429.0
RBL2	4147.0	1772.0
RRM2	4989.0	-396.0
TFDP1	-4666.5	336.5
TFDP2	5681.0	3272.0
TK1	4923.0	1201.0
TYMS	-2350.0	1068.0

---

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

metric	value
setSize	11
pMANOVA	0.0175
p.adjustMANOVA	0.109
s.dist	0.489
s.rna	0.47
s.meth	-0.137
p.rna	0.00702
p.meth	0.43

Top 20 genes

Gene	rna	meth
WEE1	5885	-4588
CCNB1	5672	-4532
YWHAB	2349	-4533
YWHAZ	4571	-1859

Click HERE to show all gene set members

All member genes

	rna	meth
CCNB1	5672	-4532
CDK1	5002	6054
CHEK1	1969	2501
SFN	-3847	-624
WEE1	5885	-4588
YWHAB	2349	-4533
YWHAE	5260	4421
YWHAG	-5097	-5370
YWHAH	3462	3603
YWHAQ	5506	598
YWHAZ	4571	-1859

---

---

Translesion synthesis by REV1

Translesion synthesis by REV1

metric	value
setSize	11
pMANOVA	0.0186
p.adjustMANOVA	0.115
s.dist	0.485
s.rna	0.462
s.meth	-0.148
p.rna	0.00794
p.meth	0.397

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
RFC2	4698	-3562
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467

Click HERE to show all gene set members

All member genes

	rna	meth
MAD2L2	-474	-823
PCNA	5482	-2043
REV1	5768	5885
REV3L	2865	5662
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Translesion synthesis by POLK

Translesion synthesis by POLK

metric	value
setSize	12
pMANOVA	0.0134
p.adjustMANOVA	0.0922
s.dist	0.483
s.rna	0.457
s.meth	-0.157
p.rna	0.00616
p.meth	0.346

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
RFC2	4698	-3562
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
POLK	2356	-1123

Click HERE to show all gene set members

All member genes

	rna	meth
MAD2L2	-474	-823
PCNA	5482	-2043
POLK	2356	-1123
REV1	5768	5885
REV3L	2865	5662
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the late endosome membrane

metric	value
setSize	10
pMANOVA	0.0308
p.adjustMANOVA	0.159
s.dist	0.482
s.rna	0.0071
s.meth	0.482
p.rna	0.969
p.meth	0.00834

Top 20 genes

Gene	rna	meth
MTMR2	5343	5510
MTM1	5597	4567
MTMR4	3141	3172
PIK3C3	1248	3513

Click HERE to show all gene set members

All member genes

	rna	meth
MTM1	5597	4567
MTMR2	5343	5510
MTMR4	3141	3172
MTMR7	-2793	5901
MTMR9	-4115	5838
PIK3C2A	2266	-1054
PIK3C3	1248	3513
PIK3R4	-3394	3498
PIKFYVE	-3202	4188
VAC14	-3196	-2856

---

---

Attenuation phase

Attenuation phase

metric	value
setSize	17
pMANOVA	0.00258
p.adjustMANOVA	0.0253
s.dist	0.481
s.rna	-0.478
s.meth	0.0546
p.rna	0.000647
p.meth	0.697

Top 20 genes

Gene	rna	meth
HSPA1A	-5355.5	6150.5
HSPA1B	-5355.5	6150.5
FKBP4	-5101.0	3899.0
COL4A6	-3334.0	3630.0
HSPH1	-5634.0	2012.0
CREBBP	-1951.0	3951.0
SERPINH1	-5318.0	777.0
HSP90AB1	-4942.0	690.0
EP300	-238.0	5212.0

Click HERE to show all gene set members

All member genes

	rna	meth
COL4A6	-3334.0	3630.0
CREBBP	-1951.0	3951.0
CRYBA4	-4716.0	-1922.0
DNAJB1	-798.0	-2161.0
DNAJB6	-3939.0	-4126.0
EP300	-238.0	5212.0
FKBP4	-5101.0	3899.0
HSBP1	-1763.0	-1709.0
HSP90AA1	-3476.0	-2340.0
HSP90AB1	-4942.0	690.0
HSPA1A	-5355.5	6150.5
HSPA1B	-5355.5	6150.5
HSPA8	-965.0	-4463.0
HSPH1	-5634.0	2012.0
PTGES3	4430.0	-4503.0
SERPINH1	-5318.0	777.0
TNFRSF21	1780.0	1143.0

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	52
pMANOVA	1.23e-08
p.adjustMANOVA	8.12e-07
s.dist	0.479
s.rna	0.467
s.meth	-0.106
p.rna	5.59e-09
p.meth	0.187

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
EIF3F	2184	-2647
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
RPL28	1364	-1226
RPL3L	4176	-333
RPL37	674	-1603

Click HERE to show all gene set members

All member genes

	rna	meth
EIF2S2	3380	6090
EIF3A	-830	5092
EIF3B	-2288	-5285
EIF3D	-1349	-3832
EIF3E	4815	3218
EIF3F	2184	-2647
EIF3G	588	384
EIF3H	2870	678
EIF3I	421	-1535
EIF3K	-20	-3
EIF3L	-3582	-5434
EIF3M	3606	3235
EIF4B	3469	3512
EIF4G1	-3291	-2899
EIF4H	2252	1194
EIF5	5141	53
EIF5B	-2435	4468
FAU	2178	4979
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507

---

---

G0 and Early G1

G0 and Early G1

metric	value
setSize	24
pMANOVA	0.000344
p.adjustMANOVA	0.00541
s.dist	0.477
s.rna	0.453
s.meth	0.148
p.rna	0.000123
p.meth	0.209

Top 20 genes

Gene	rna	meth
CDK1	5002	6054
RBL1	5415	5429
TFDP2	5681	3272
LIN52	5395	2218
DYRK1A	2371	4825
LIN9	3039	3094
CCNE2	3133	2869
LIN54	2425	3567
RBL2	4147	1772
E2F5	1991	267
CDC6	5060	9

Click HERE to show all gene set members

All member genes

	rna	meth
CCNA2	5667.0	-564.0
CCNE1	-783.0	5758.0
CCNE2	3133.0	2869.0
CDC25A	-142.0	3481.0
CDC6	5060.0	9.0
CDK1	5002.0	6054.0
CDK2	4841.0	-3300.0
DYRK1A	2371.0	4825.0
E2F1	4894.0	-699.0
E2F4	-2228.0	-259.0
E2F5	1991.0	267.0
LIN37	-3419.0	372.0
LIN52	5395.0	2218.0
LIN54	2425.0	3567.0
LIN9	3039.0	3094.0
MAX	5734.0	-804.0
MYBL2	4863.0	-3379.0
MYC	-3998.0	-178.0
PCNA	5482.0	-2043.0
RBL1	5415.0	5429.0
RBL2	4147.0	1772.0
TFDP1	-4666.5	336.5
TFDP2	5681.0	3272.0
TOP2A	4755.0	-1459.0

---

---

Defective B3GALTL causes Peters-plus syndrome (PpS)

Defective B3GALTL causes Peters-plus syndrome (PpS)

metric	value
setSize	29
pMANOVA	3.74e-05
p.adjustMANOVA	0.00087
s.dist	0.476
s.rna	-0.2
s.meth	0.432
p.rna	0.0623
p.meth	5.59e-05

Top 20 genes

Gene	rna	meth
THBS1	-5738	5278
ADAMTS15	-5331	4703
ADAMTSL1	-4028	6050
ADAMTS1	-4067	5991
ADAMTS14	-4057	5816
ADAMTS9	-4250	4873
ADAMTS12	-5029	3611
ADAMTS19	-2967	3521
SEMA5B	-4830	1511
THSD1	-1403	5072
ADAMTS4	-5793	931
ADAMTS10	-2957	1243
ADAMTS2	-96	211

Click HERE to show all gene set members

All member genes

	rna	meth
ADAMTS1	-4067.0	5991.0
ADAMTS10	-2957.0	1243.0
ADAMTS12	-5029.0	3611.0
ADAMTS13	4852.0	740.0
ADAMTS14	-4057.0	5816.0
ADAMTS15	-5331.0	4703.0
ADAMTS17	-2800.0	-880.0
ADAMTS19	-2967.0	3521.0
ADAMTS2	-96.0	211.0
ADAMTS3	3751.0	4028.0
ADAMTS4	-5793.0	931.0
ADAMTS5	-3832.0	-361.0
ADAMTS7	3721.0	3641.0
ADAMTS8	803.0	4992.0
ADAMTS9	-4250.0	4873.0
ADAMTSL1	-4028.0	6050.0
ADAMTSL2	-3520.5	-216.5
ADAMTSL3	5521.0	5786.0
ADAMTSL4	4480.0	1819.0
ADAMTSL5	-4874.0	-391.0
CFP	4482.0	4899.0
SEMA5B	-4830.0	1511.0
SPON2	-5787.0	-2679.0
THBS1	-5738.0	5278.0
THBS2	5522.0	4904.0
THSD1	-1403.0	5072.0
THSD4	4805.0	1616.0
THSD7A	358.0	5215.0
THSD7B	571.0	3192.0

---

---

Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER

metric	value
setSize	19
pMANOVA	0.00145
p.adjustMANOVA	0.0165
s.dist	0.474
s.rna	0.461
s.meth	-0.11
p.rna	0.000499
p.meth	0.407

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
POLE3	4843	-3859
RFC2	4698	-3562
POLE	4844	-2625
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
POLK	2356	-1123
POLD1	1755	-558

Click HERE to show all gene set members

All member genes

	rna	meth
LIG1	4632	4263
LIG3	3193	1807
PCNA	5482	-2043
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
POLE	4844	-2625
POLE2	1410	4648
POLE3	4843	-3859
POLE4	3954	4417
POLK	2356	-1123
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991
XRCC1	-4368	-441

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	55
pMANOVA	6.93e-09
p.adjustMANOVA	5.13e-07
s.dist	0.473
s.rna	0.456
s.meth	-0.122
p.rna	4.82e-09
p.meth	0.117

Top 20 genes

Gene	rna	meth
RPL10	5718	-4740
RPS27	5413	-4396
SRP72	4388	-4856
RPL8	4009	-4579
RPL34	3883	-4453
RPL37A	3795	-4315
RPL7	4857	-3120
RPS4X	5123	-2906
RPS6	3537	-4104
RPS19	3761	-3788
RPL32	4757	-2913
RPS15	2330	-4902
RPL14	3458	-2532
RPS23	4486	-1473
RPL38	3244	-1654
RPS26	1768	-2630
RPL15	1902	-2225
SRP19	1267	-2927
SEC61A2	3081	-928
RPL28	1364	-1226

Click HERE to show all gene set members

All member genes

	rna	meth
DDOST	-2771	-3245
FAU	2178	4979
RPL10	5718	-4740
RPL11	4194	2405
RPL14	3458	-2532
RPL15	1902	-2225
RPL22	1607	2427
RPL22L1	5748	4255
RPL26	4617	1424
RPL28	1364	-1226
RPL3	-182	-4340
RPL30	3782	1289
RPL31	2374	4673
RPL32	4757	-2913
RPL34	3883	-4453
RPL36A	5374	780
RPL37	674	-1603
RPL37A	3795	-4315
RPL38	3244	-1654
RPL3L	4176	-333
RPL5	5000	741
RPL7	4857	-3120
RPL8	4009	-4579
RPN1	-3398	-4866
RPN2	-1577	-686
RPS14	2316	2783
RPS15	2330	-4902
RPS15A	5224	5585
RPS19	3761	-3788
RPS23	4486	-1473
RPS24	5349	5479
RPS26	1768	-2630
RPS27	5413	-4396
RPS27L	5710	5104
RPS4X	5123	-2906
RPS5	4341	1766
RPS6	3537	-4104
RPS9	3320	1507
SEC11A	4832	2523
SEC11C	1416	-401
SEC61A1	-1151	2026
SEC61A2	3081	-928
SEC61G	3126	3540
SPCS3	1838	1301
SRP14	213	1695
SRP19	1267	-2927
SRP54	4721	4322
SRP68	174	-2731
SRP72	4388	-4856
SRP9	1803	1979
SRPRB	-4241	-1984
SSR1	-1010	-2003
SSR2	-2153	2570
SSR3	4036	4987
TRAM1	5108	62

---

---

LGI-ADAM interactions

LGI-ADAM interactions

metric	value
setSize	11
pMANOVA	0.0269
p.adjustMANOVA	0.147
s.dist	0.472
s.rna	-0.46
s.meth	-0.107
p.rna	0.00826
p.meth	0.538

Top 20 genes

Gene	rna	meth
STX1B	-5054	-4932
LGI4	-4756	-4074
LGI1	-5560	-1347
DLG4	-1575	-3560
STX1A	-2529	-944

Click HERE to show all gene set members

All member genes

	rna	meth
ADAM11	-5474	862
ADAM22	5635	5771
ADAM23	-1639	2032
CACNG2	102	-2648
DLG4	-1575	-3560
LGI1	-5560	-1347
LGI2	-4043	4764
LGI3	-4169	1685
LGI4	-4756	-4074
STX1A	-2529	-944
STX1B	-5054	-4932

---

---

Cholesterol biosynthesis

Cholesterol biosynthesis

metric	value
setSize	20
pMANOVA	0.00151
p.adjustMANOVA	0.0168
s.dist	0.472
s.rna	-0.439
s.meth	-0.173
p.rna	0.000674
p.meth	0.18

Top 20 genes

Gene	rna	meth
MVK	-4906	-4312
ACAT2	-3947	-5012
CYP51A1	-5604	-3160
IDI1	-3604	-4085
EBP	-3695	-2621
SC5D	-4483	-1762
FDPS	-357	-5344
NSDHL	-3751	-304
PMVK	-206	-5103
HMGCS1	-2172	-89

Click HERE to show all gene set members

All member genes

	rna	meth
ACAT2	-3947	-5012
CYP51A1	-5604	-3160
DHCR24	-5678	1412
DHCR7	1012	4049
EBP	-3695	-2621
FDFT1	5661	-4376
FDPS	-357	-5344
HMGCR	-1725	974
HMGCS1	-2172	-89
HSD17B7	-1454	5409
IDI1	-3604	-4085
LBR	227	-2528
LSS	-1938	2716
MSMO1	-4088	5895
MVD	-4618	6187
MVK	-4906	-4312
NSDHL	-3751	-304
PMVK	-206	-5103
SC5D	-4483	-1762
SQLE	-5049	6

---

---

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

metric	value
setSize	28
pMANOVA	8.03e-05
p.adjustMANOVA	0.00168
s.dist	0.472
s.rna	0.47
s.meth	-0.0416
p.rna	1.66e-05
p.meth	0.703

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
RFC2	4698	-3562
ORC2	4580	-3653
CDK2	4841	-3300
MCM4	4969	-2519
MCM2	3949	-2945
RFC5	2855	-3883
CDC7	3232	-2078
ORC5	2704	-2327
RFC4	1591	-3467
RAD1	1050	-997
ATRIP	473	-2188
MCM5	4901	-57

Click HERE to show all gene set members

All member genes

	rna	meth
ATR	2139	3631
ATRIP	473	-2188
CDC25A	-142	3481
CDC6	5060	9
CDC7	3232	-2078
CDK2	4841	-3300
CHEK1	1969	2501
CLSPN	3958	3885
DBF4	2421	3020
HUS1	2213	2868
MCM10	3772	1777
MCM2	3949	-2945
MCM3	3470	5749
MCM4	4969	-2519
MCM5	4901	-57
MCM6	5598	5733
ORC2	4580	-3653
ORC3	3651	4741
ORC4	1249	5675
ORC5	2704	-2327
RAD1	1050	-997
RAD9B	-2914	-2638
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

metric	value
setSize	12
pMANOVA	0.0203
p.adjustMANOVA	0.124
s.dist	0.469
s.rna	0.46
s.meth	0.0882
p.rna	0.00577
p.meth	0.597

Top 20 genes

Gene	rna	meth
EXO1	4570	6169
LIG1	4632	4263
POLD3	4266	3682
POLD2	3149	1080
RPA1	2329	207

Click HERE to show all gene set members

All member genes

	rna	meth
EXO1	4570	6169
LIG1	4632	4263
MLH1	-3030	4552
MSH2	3630	-1200
MSH6	-643	4079
PCNA	5482	-2043
PMS2	1428	-4129
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
RPA1	2329	207
RPA2	5310	-4991

---

---

Lagging Strand Synthesis

Lagging Strand Synthesis

metric	value
setSize	17
pMANOVA	0.00345
p.adjustMANOVA	0.0332
s.dist	0.467
s.rna	0.452
s.meth	-0.115
p.rna	0.00125
p.meth	0.41

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
PRIM1	4883	-4606
RFC2	4698	-3562
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
DNA2	1719	-2587
POLD1	1755	-558

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	1719	-2587
LIG1	4632	4263
PCNA	5482	-2043
POLA1	5689	4389
POLA2	-2707	1499
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
PRIM1	4883	-4606
PRIM2	248	4044
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

metric	value
setSize	19
pMANOVA	0.00198
p.adjustMANOVA	0.021
s.dist	0.466
s.rna	0.466
s.meth	-0.0215
p.rna	0.000441
p.meth	0.871

Top 20 genes

Gene	rna	meth
RPA2	5310	-4991
POLE3	4843	-3859
RFC2	4698	-3562
POLE	4844	-2625
PCNA	5482	-2043
RFC5	2855	-3883
RFC4	1591	-3467
POLD1	1755	-558

Click HERE to show all gene set members

All member genes

	rna	meth
LIG1	4632	4263
PARG	4579	5926
PARP1	-2189	4063
PCNA	5482	-2043
POLB	-721	72
POLD1	1755	-558
POLD2	3149	1080
POLD3	4266	3682
POLE	4844	-2625
POLE2	1410	4648
POLE3	4843	-3859
POLE4	3954	4417
RFC1	1539	2036
RFC2	4698	-3562
RFC3	-1696	-2
RFC4	1591	-3467
RFC5	2855	-3883
RPA1	2329	207
RPA2	5310	-4991

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0   GGally_2.0.0    ggplot2_3.3.2   reshape2_1.4.4 
##  [5] beeswarm_0.2.3  gplots_3.0.3    gtools_3.8.2    tibble_3.0.1   
##  [9] dplyr_1.0.0     echarts4r_0.3.2 mitch_1.0.6    
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.4.6       assertthat_0.2.1   rprojroot_1.3-2    digest_0.6.25     
##  [5] mime_0.9           R6_2.4.1           plyr_1.8.6         backports_1.1.8   
##  [9] evaluate_0.14      highr_0.8          pillar_1.4.4       rlang_0.4.6       
## [13] gdata_2.18.0       rmarkdown_2.3      desc_1.2.0         labeling_0.3      
## [17] stringr_1.4.0      htmlwidgets_1.5.1  munsell_0.5.0      shiny_1.5.0       
## [21] compiler_4.0.2     httpuv_1.5.4       xfun_0.15          pkgconfig_2.0.3   
## [25] htmltools_0.5.0    tidyselect_1.1.0   gridExtra_2.3      reshape_0.8.8     
## [29] crayon_1.3.4       withr_2.2.0        later_1.1.0.1      MASS_7.3-51.6     
## [33] bitops_1.0-6       grid_4.0.2         jsonlite_1.7.0     xtable_1.8-4      
## [37] gtable_0.3.0       lifecycle_0.2.0    magrittr_1.5       scales_1.1.1      
## [41] KernSmooth_2.23-17 stringi_1.4.6      farver_2.0.3       promises_1.1.1    
## [45] testthat_2.3.2     ellipsis_0.3.1     generics_0.0.2     vctrs_0.3.1       
## [49] pbmcapply_1.5.0    RColorBrewer_1.1-2 tools_4.0.2        glue_1.4.1        
## [53] purrr_0.3.4        parallel_4.0.2     fastmap_1.0.1      yaml_2.2.1        
## [57] colorspace_1.4-1   caTools_1.18.0     knitr_1.29

END of report