Mitch Report

date generated: 2020-07-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                rna       meth
## A2M    -0.27091788  0.7954409
## A4GALT  1.99263712 -2.0417950
## AAAS    1.07279989  1.6838904
## AACS   -0.00214706 -8.1534153
## AAED1  -1.15426628  2.3949705
## AAK1   -3.04234381  1.6662134

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	11716
duplicated_genes_present	0
num_profile_genes_in_sets	6727
num_profile_genes_not_in_sets	4989
profile_pearson_correl	0.02021
profile_spearman_correl	0.00198

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1144
num_genesets_included	1256

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 158

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.rna	s.meth	p.rna	p.meth
Glucuronidation	11	2.86e-05	8.76e-04	0.797	0.524	0.6000	2.60e-03	0.000564
Interferon alpha/beta signaling	42	2.73e-14	3.43e-11	0.704	0.649	-0.2730	3.43e-13	0.002180
Classical antibody-mediated complement activation	10	6.74e-04	1.19e-02	0.698	0.684	-0.1390	1.82e-04	0.446000
Initial triggering of complement	19	1.21e-06	9.52e-05	0.691	0.614	-0.3180	3.63e-06	0.016600
Phosphorylation of CD3 and TCR zeta chains	10	1.65e-03	2.20e-02	0.654	0.637	-0.1440	4.82e-04	0.430000
LGI-ADAM interactions	11	9.86e-04	1.64e-02	0.648	-0.593	-0.2610	6.54e-04	0.134000
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	10	2.05e-03	2.58e-02	0.642	-0.633	0.1100	5.29e-04	0.549000
Creation of C4 and C2 activators	12	1.55e-03	2.14e-02	0.599	0.585	-0.1320	4.53e-04	0.430000
Signaling by Activin	10	5.06e-03	4.41e-02	0.593	-0.527	0.2730	3.92e-03	0.135000
Removal of the Flap Intermediate	11	3.12e-03	3.29e-02	0.591	0.439	-0.3960	1.18e-02	0.022900
PI-3K cascade:FGFR2	14	8.00e-04	1.38e-02	0.582	-0.511	0.2790	9.27e-04	0.070700
PI-3K cascade:FGFR4	11	3.92e-03	3.90e-02	0.579	-0.511	0.2740	3.37e-03	0.116000
Cholesterol biosynthesis	20	4.46e-05	1.27e-03	0.579	-0.539	-0.2110	3.05e-05	0.102000
Removal of the Flap Intermediate from the C-strand	12	2.80e-03	3.08e-02	0.571	0.481	-0.3090	3.95e-03	0.064200
HSF1-dependent transactivation	26	3.16e-06	1.50e-04	0.570	-0.560	-0.1090	7.74e-07	0.336000
Processive synthesis on the lagging strand	12	3.09e-03	3.29e-02	0.566	0.476	-0.3070	4.30e-03	0.065800
Peptide chain elongation	37	2.92e-08	5.24e-06	0.560	0.558	0.0462	4.32e-09	0.627000
STING mediated induction of host immune responses	11	6.76e-03	5.30e-02	0.550	0.433	-0.3390	1.28e-02	0.051800
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	11	7.15e-03	5.51e-02	0.547	-0.342	0.4270	4.97e-02	0.014200
TRAF6-mediated induction of TAK1 complex within TLR4 complex	11	7.15e-03	5.51e-02	0.547	-0.342	0.4270	4.97e-02	0.014200
DNA strand elongation	26	8.88e-06	3.01e-04	0.546	0.527	-0.1440	3.30e-06	0.205000
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	16	1.02e-03	1.64e-02	0.536	-0.402	0.3540	5.39e-03	0.014200
Response of EIF2AK4 (GCN2) to amino acid deficiency	45	4.65e-09	1.17e-06	0.534	0.523	0.1100	1.33e-09	0.202000
FRS-mediated FGFR2 signaling	15	1.64e-03	2.20e-02	0.534	-0.443	0.2970	2.96e-03	0.046500
Selenocysteine synthesis	40	4.00e-08	6.27e-06	0.533	0.533	0.0240	5.48e-09	0.793000
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	9.19e-03	6.50e-02	0.533	-0.322	0.4240	6.43e-02	0.014800
Termination of translesion DNA synthesis	23	7.15e-05	1.91e-03	0.526	0.456	-0.2620	1.55e-04	0.029400
Regulation of IFNA signaling	12	7.56e-03	5.65e-02	0.521	0.485	-0.1900	3.64e-03	0.254000
Viral mRNA Translation	37	3.07e-07	3.21e-05	0.521	0.517	0.0575	5.20e-08	0.545000
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	1.17e-02	7.44e-02	0.520	0.451	0.2590	9.68e-03	0.137000
FRS-mediated FGFR4 signaling	12	7.84e-03	5.76e-02	0.519	-0.426	0.2960	1.07e-02	0.075500
Mitotic Telophase/Cytokinesis	10	1.97e-02	1.04e-01	0.512	0.292	0.4210	1.09e-01	0.021300
Telomere C-strand synthesis initiation	10	1.98e-02	1.04e-01	0.511	0.462	-0.2190	1.14e-02	0.231000
FCGR activation	16	2.05e-03	2.58e-02	0.508	0.508	-0.0210	4.40e-04	0.885000
Activation of AMPK downstream of NMDARs	10	2.29e-02	1.14e-01	0.502	-0.432	-0.2560	1.80e-02	0.161000
Attenuation phase	17	1.84e-03	2.39e-02	0.497	-0.497	0.0210	3.92e-04	0.881000
Polymerase switching on the C-strand of the telomere	21	5.24e-04	9.82e-03	0.490	0.394	-0.2900	1.76e-03	0.021400
Cleavage of the damaged pyrimidine	13	9.91e-03	6.69e-02	0.486	0.431	-0.2260	7.19e-03	0.159000
Depyrimidination	13	9.91e-03	6.69e-02	0.486	0.431	-0.2260	7.19e-03	0.159000
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	13	9.91e-03	6.69e-02	0.486	0.431	-0.2260	7.19e-03	0.159000
Lagging Strand Synthesis	17	2.54e-03	2.90e-02	0.484	0.403	-0.2680	4.02e-03	0.056100
Processive synthesis on the C-strand of the telomere	14	7.55e-03	5.65e-02	0.482	0.450	-0.1730	3.54e-03	0.263000
ATF6 (ATF6-alpha) activates chaperones	10	3.06e-02	1.36e-01	0.482	-0.208	0.4340	2.54e-01	0.017400
GRB2 events in EGFR signaling	10	3.22e-02	1.40e-01	0.478	-0.211	0.4300	2.49e-01	0.018700
Eukaryotic Translation Elongation	40	1.13e-06	9.49e-05	0.478	0.477	0.0403	1.84e-07	0.659000
Signaling by BMP	20	1.05e-03	1.64e-02	0.478	-0.346	0.3300	7.44e-03	0.010600
Antimicrobial peptides	11	2.38e-02	1.17e-01	0.476	0.453	-0.1440	9.22e-03	0.408000
Activation of the pre-replicative complex	26	1.66e-04	3.86e-03	0.473	0.473	-0.0135	3.04e-05	0.906000
Eukaryotic Translation Termination	40	1.82e-06	1.21e-04	0.470	0.463	0.0786	3.97e-07	0.390000
Negative regulation of FGFR2 signaling	21	1.12e-03	1.69e-02	0.464	-0.388	0.2560	2.10e-03	0.042700

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.rna	s.meth	p.rna	p.meth
Glucuronidation	11	2.86e-05	8.76e-04	0.79700	0.524000	0.600000	2.60e-03	0.000564
Interferon alpha/beta signaling	42	2.73e-14	3.43e-11	0.70400	0.649000	-0.273000	3.43e-13	0.002180
Classical antibody-mediated complement activation	10	6.74e-04	1.19e-02	0.69800	0.684000	-0.139000	1.82e-04	0.446000
Initial triggering of complement	19	1.21e-06	9.52e-05	0.69100	0.614000	-0.318000	3.63e-06	0.016600
Phosphorylation of CD3 and TCR zeta chains	10	1.65e-03	2.20e-02	0.65400	0.637000	-0.144000	4.82e-04	0.430000
LGI-ADAM interactions	11	9.86e-04	1.64e-02	0.64800	-0.593000	-0.261000	6.54e-04	0.134000
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	10	2.05e-03	2.58e-02	0.64200	-0.633000	0.110000	5.29e-04	0.549000
Creation of C4 and C2 activators	12	1.55e-03	2.14e-02	0.59900	0.585000	-0.132000	4.53e-04	0.430000
Signaling by Activin	10	5.06e-03	4.41e-02	0.59300	-0.527000	0.273000	3.92e-03	0.135000
Removal of the Flap Intermediate	11	3.12e-03	3.29e-02	0.59100	0.439000	-0.396000	1.18e-02	0.022900
PI-3K cascade:FGFR2	14	8.00e-04	1.38e-02	0.58200	-0.511000	0.279000	9.27e-04	0.070700
PI-3K cascade:FGFR4	11	3.92e-03	3.90e-02	0.57900	-0.511000	0.274000	3.37e-03	0.116000
Cholesterol biosynthesis	20	4.46e-05	1.27e-03	0.57900	-0.539000	-0.211000	3.05e-05	0.102000
Removal of the Flap Intermediate from the C-strand	12	2.80e-03	3.08e-02	0.57100	0.481000	-0.309000	3.95e-03	0.064200
HSF1-dependent transactivation	26	3.16e-06	1.50e-04	0.57000	-0.560000	-0.109000	7.74e-07	0.336000
Processive synthesis on the lagging strand	12	3.09e-03	3.29e-02	0.56600	0.476000	-0.307000	4.30e-03	0.065800
Peptide chain elongation	37	2.92e-08	5.24e-06	0.56000	0.558000	0.046200	4.32e-09	0.627000
STING mediated induction of host immune responses	11	6.76e-03	5.30e-02	0.55000	0.433000	-0.339000	1.28e-02	0.051800
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	11	7.15e-03	5.51e-02	0.54700	-0.342000	0.427000	4.97e-02	0.014200
TRAF6-mediated induction of TAK1 complex within TLR4 complex	11	7.15e-03	5.51e-02	0.54700	-0.342000	0.427000	4.97e-02	0.014200
DNA strand elongation	26	8.88e-06	3.01e-04	0.54600	0.527000	-0.144000	3.30e-06	0.205000
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	16	1.02e-03	1.64e-02	0.53600	-0.402000	0.354000	5.39e-03	0.014200
Response of EIF2AK4 (GCN2) to amino acid deficiency	45	4.65e-09	1.17e-06	0.53400	0.523000	0.110000	1.33e-09	0.202000
FRS-mediated FGFR2 signaling	15	1.64e-03	2.20e-02	0.53400	-0.443000	0.297000	2.96e-03	0.046500
Selenocysteine synthesis	40	4.00e-08	6.27e-06	0.53300	0.533000	0.024000	5.48e-09	0.793000
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	9.19e-03	6.50e-02	0.53300	-0.322000	0.424000	6.43e-02	0.014800
Termination of translesion DNA synthesis	23	7.15e-05	1.91e-03	0.52600	0.456000	-0.262000	1.55e-04	0.029400
Regulation of IFNA signaling	12	7.56e-03	5.65e-02	0.52100	0.485000	-0.190000	3.64e-03	0.254000
Viral mRNA Translation	37	3.07e-07	3.21e-05	0.52100	0.517000	0.057500	5.20e-08	0.545000
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	1.17e-02	7.44e-02	0.52000	0.451000	0.259000	9.68e-03	0.137000
FRS-mediated FGFR4 signaling	12	7.84e-03	5.76e-02	0.51900	-0.426000	0.296000	1.07e-02	0.075500
Mitotic Telophase/Cytokinesis	10	1.97e-02	1.04e-01	0.51200	0.292000	0.421000	1.09e-01	0.021300
Telomere C-strand synthesis initiation	10	1.98e-02	1.04e-01	0.51100	0.462000	-0.219000	1.14e-02	0.231000
FCGR activation	16	2.05e-03	2.58e-02	0.50800	0.508000	-0.021000	4.40e-04	0.885000
Activation of AMPK downstream of NMDARs	10	2.29e-02	1.14e-01	0.50200	-0.432000	-0.256000	1.80e-02	0.161000
Attenuation phase	17	1.84e-03	2.39e-02	0.49700	-0.497000	0.021000	3.92e-04	0.881000
Polymerase switching on the C-strand of the telomere	21	5.24e-04	9.82e-03	0.49000	0.394000	-0.290000	1.76e-03	0.021400
Cleavage of the damaged pyrimidine	13	9.91e-03	6.69e-02	0.48600	0.431000	-0.226000	7.19e-03	0.159000
Depyrimidination	13	9.91e-03	6.69e-02	0.48600	0.431000	-0.226000	7.19e-03	0.159000
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	13	9.91e-03	6.69e-02	0.48600	0.431000	-0.226000	7.19e-03	0.159000
Lagging Strand Synthesis	17	2.54e-03	2.90e-02	0.48400	0.403000	-0.268000	4.02e-03	0.056100
Processive synthesis on the C-strand of the telomere	14	7.55e-03	5.65e-02	0.48200	0.450000	-0.173000	3.54e-03	0.263000
ATF6 (ATF6-alpha) activates chaperones	10	3.06e-02	1.36e-01	0.48200	-0.208000	0.434000	2.54e-01	0.017400
GRB2 events in EGFR signaling	10	3.22e-02	1.40e-01	0.47800	-0.211000	0.430000	2.49e-01	0.018700
Eukaryotic Translation Elongation	40	1.13e-06	9.49e-05	0.47800	0.477000	0.040300	1.84e-07	0.659000
Signaling by BMP	20	1.05e-03	1.64e-02	0.47800	-0.346000	0.330000	7.44e-03	0.010600
Antimicrobial peptides	11	2.38e-02	1.17e-01	0.47600	0.453000	-0.144000	9.22e-03	0.408000
Activation of the pre-replicative complex	26	1.66e-04	3.86e-03	0.47300	0.473000	-0.013500	3.04e-05	0.906000
Eukaryotic Translation Termination	40	1.82e-06	1.21e-04	0.47000	0.463000	0.078600	3.97e-07	0.390000
Negative regulation of FGFR2 signaling	21	1.12e-03	1.69e-02	0.46400	-0.388000	0.256000	2.10e-03	0.042700
EGFR downregulation	24	4.72e-04	9.13e-03	0.46100	-0.362000	0.285000	2.12e-03	0.015700
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	2.20e-02	1.11e-01	0.46000	0.395000	-0.237000	1.80e-02	0.155000
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	2.41e-02	1.18e-01	0.45500	0.405000	-0.207000	1.51e-02	0.215000
Prolactin receptor signaling	11	3.33e-02	1.42e-01	0.45400	-0.360000	0.276000	3.88e-02	0.112000
Generation of second messenger molecules	20	2.35e-03	2.79e-02	0.45000	0.449000	0.018400	5.08e-04	0.887000
Leading Strand Synthesis	13	2.04e-02	1.05e-01	0.44700	0.367000	-0.254000	2.19e-02	0.113000
Polymerase switching	13	2.04e-02	1.05e-01	0.44700	0.367000	-0.254000	2.19e-02	0.113000
RHO GTPases Activate NADPH Oxidases	18	4.62e-03	4.39e-02	0.44600	0.291000	-0.338000	3.27e-02	0.013000
G1/S-Specific Transcription	24	7.97e-04	1.38e-02	0.44600	0.444000	-0.032300	1.65e-04	0.784000
Signaling by FGFR4 in disease	10	5.13e-02	1.82e-01	0.44500	-0.155000	0.417000	3.95e-01	0.022500
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	41	5.61e-06	2.01e-04	0.44400	0.428000	0.118000	2.11e-06	0.191000
Negative regulation of FGFR4 signaling	18	5.00e-03	4.41e-02	0.44300	-0.367000	0.248000	7.08e-03	0.068400
Base-Excision Repair, AP Site Formation	15	1.24e-02	7.65e-02	0.44100	0.381000	-0.223000	1.07e-02	0.135000
Downregulation of SMAD2/3:SMAD4 transcriptional activity	17	7.48e-03	5.65e-02	0.43800	-0.368000	0.237000	8.60e-03	0.090300
G0 and Early G1	24	1.01e-03	1.64e-02	0.43800	0.435000	-0.051000	2.26e-04	0.665000
SHC-mediated cascade:FGFR2	14	1.87e-02	9.97e-02	0.43500	-0.307000	0.308000	4.68e-02	0.045700
Establishment of Sister Chromatid Cohesion	10	5.88e-02	2.02e-01	0.43500	0.350000	0.259000	5.54e-02	0.157000
Formation of a pool of free 40S subunits	46	2.31e-06	1.38e-04	0.43400	0.433000	0.033900	3.77e-07	0.691000
Telomere C-strand (Lagging Strand) Synthesis	27	5.17e-04	9.82e-03	0.43200	0.369000	-0.226000	9.18e-04	0.042400
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	6.35e-02	2.14e-01	0.42800	-0.287000	0.318000	1.16e-01	0.081800
Downstream signaling of activated FGFR2	20	4.06e-03	3.95e-02	0.42800	-0.299000	0.307000	2.07e-02	0.017500
Nephrin family interactions	19	5.56e-03	4.57e-02	0.42800	0.290000	0.314000	2.87e-02	0.017800
MET activates RAP1 and RAC1	11	4.92e-02	1.78e-01	0.42700	-0.118000	0.411000	4.98e-01	0.018400
PI-3K cascade:FGFR3	12	3.83e-02	1.50e-01	0.42600	-0.391000	0.169000	1.92e-02	0.310000
Transcription of E2F targets under negative control by DREAM complex	17	1.17e-02	7.44e-02	0.41800	0.405000	-0.103000	3.85e-03	0.462000
InlB-mediated entry of Listeria monocytogenes into host cell	11	5.60e-02	1.94e-01	0.41800	-0.325000	0.262000	6.20e-02	0.132000
GRB2 events in ERBB2 signaling	14	2.71e-02	1.29e-01	0.41400	-0.168000	0.379000	2.75e-01	0.014200
GTP hydrolysis and joining of the 60S ribosomal subunit	52	1.83e-06	1.21e-04	0.41200	0.407000	0.066300	3.87e-07	0.409000
activated TAK1 mediates p38 MAPK activation	17	1.31e-02	7.84e-02	0.41200	-0.394000	0.122000	4.93e-03	0.385000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	49	4.27e-06	1.63e-04	0.41100	0.407000	-0.054400	8.33e-07	0.510000
Listeria monocytogenes entry into host cells	15	2.24e-02	1.13e-01	0.41100	-0.342000	0.227000	2.18e-02	0.128000
L13a-mediated translational silencing of Ceruloplasmin expression	50	3.86e-06	1.63e-04	0.40800	0.405000	0.056200	7.55e-07	0.492000
Regulation of necroptotic cell death	12	5.14e-02	1.82e-01	0.40700	0.319000	0.252000	5.56e-02	0.131000
SHC1 events in ERBB4 signaling	12	5.11e-02	1.82e-01	0.40600	-0.080000	0.399000	6.32e-01	0.016800
CD28 dependent Vav1 pathway	12	5.23e-02	1.84e-01	0.40500	0.367000	0.172000	2.77e-02	0.303000
SHC1 events in EGFR signaling	11	6.66e-02	2.22e-01	0.40500	-0.115000	0.388000	5.08e-01	0.025700
Gap-filling DNA repair synthesis and ligation in GG-NER	19	9.32e-03	6.50e-02	0.40500	0.389000	-0.114000	3.35e-03	0.391000
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	14	3.25e-02	1.41e-01	0.40400	0.401000	-0.047400	9.35e-03	0.759000
Mismatch Repair	13	4.14e-02	1.59e-01	0.40400	0.346000	-0.209000	3.09e-02	0.192000
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	8.72e-02	2.63e-01	0.40400	-0.312000	-0.257000	8.79e-02	0.160000
Downstream signaling of activated FGFR4	17	1.56e-02	8.67e-02	0.40400	-0.261000	0.308000	6.27e-02	0.027900
Selenoamino acid metabolism	52	3.22e-06	1.50e-04	0.40300	0.403000	0.012100	4.97e-07	0.880000
Glutamate and glutamine metabolism	12	5.39e-02	1.89e-01	0.40300	0.063100	-0.398000	7.05e-01	0.017000
HDMs demethylate histones	19	1.03e-02	6.86e-02	0.40100	-0.361000	0.174000	6.45e-03	0.189000
MET activates RAS signaling	10	9.12e-02	2.72e-01	0.40000	0.014200	0.400000	9.38e-01	0.028700
Regulation of PTEN mRNA translation	11	7.16e-02	2.31e-01	0.40000	-0.191000	0.351000	2.72e-01	0.043900
SHC-mediated cascade:FGFR4	11	7.17e-02	2.31e-01	0.39900	-0.251000	0.311000	1.50e-01	0.074200
IRE1alpha activates chaperones	44	3.48e-05	1.04e-03	0.39500	-0.286000	-0.273000	1.02e-03	0.001770
Constitutive Signaling by EGFRvIII	15	3.06e-02	1.36e-01	0.39400	-0.172000	0.354000	2.50e-01	0.017600
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	15	3.06e-02	1.36e-01	0.39400	-0.172000	0.354000	2.50e-01	0.017600
Signaling by EGFRvIII in Cancer	15	3.06e-02	1.36e-01	0.39400	-0.172000	0.354000	2.50e-01	0.017600
Signaling by Ligand-Responsive EGFR Variants in Cancer	15	3.06e-02	1.36e-01	0.39400	-0.172000	0.354000	2.50e-01	0.017600
PCNA-Dependent Long Patch Base Excision Repair	17	1.94e-02	1.03e-01	0.39300	0.373000	-0.124000	7.77e-03	0.376000
SRP-dependent cotranslational protein targeting to membrane	55	3.08e-06	1.50e-04	0.39300	0.393000	0.017300	4.81e-07	0.825000
XBP1(S) activates chaperone genes	42	6.37e-05	1.78e-03	0.39300	-0.257000	-0.297000	3.95e-03	0.000888
Activation of ATR in response to replication stress	28	1.66e-03	2.20e-02	0.39100	0.390000	0.024900	3.56e-04	0.819000
Cytosolic sulfonation of small molecules	13	5.11e-02	1.82e-01	0.39000	0.325000	-0.216000	4.25e-02	0.177000
PKA activation	17	2.07e-02	1.07e-01	0.39000	-0.344000	0.184000	1.42e-02	0.189000
Prolonged ERK activation events	13	5.17e-02	1.83e-01	0.39000	-0.265000	0.285000	9.79e-02	0.074900
Signaling by EGFR in Cancer	18	1.70e-02	9.19e-02	0.38800	-0.182000	0.343000	1.81e-01	0.011800
PKA-mediated phosphorylation of CREB	19	1.36e-02	7.86e-02	0.38800	-0.301000	0.245000	2.32e-02	0.064200
Cyclin A/B1/B2 associated events during G2/M transition	20	1.22e-02	7.58e-02	0.38400	0.326000	0.202000	1.16e-02	0.117000
Signaling by NODAL	12	7.23e-02	2.32e-01	0.38300	-0.326000	-0.200000	5.05e-02	0.230000
Formation of the ternary complex, and subsequently, the 43S complex	26	3.38e-03	3.50e-02	0.38300	0.355000	0.143000	1.74e-03	0.208000
RIPK1-mediated regulated necrosis	14	4.76e-02	1.76e-01	0.38100	0.330000	0.190000	3.24e-02	0.217000
Regulated Necrosis	14	4.76e-02	1.76e-01	0.38100	0.330000	0.190000	3.24e-02	0.217000
Polo-like kinase mediated events	13	5.95e-02	2.03e-01	0.38100	0.380000	0.019400	1.76e-02	0.904000
Signaling by WNT in cancer	25	4.74e-03	4.41e-02	0.37800	-0.370000	0.076000	1.36e-03	0.511000
Diseases associated with glycosylation precursor biosynthesis	16	3.28e-02	1.42e-01	0.37800	-0.034700	-0.376000	8.10e-01	0.009200
FRS-mediated FGFR3 signaling	13	6.19e-02	2.09e-01	0.37800	-0.321000	0.198000	4.49e-02	0.216000
Cap-dependent Translation Initiation	58	4.42e-06	1.63e-04	0.37700	0.377000	0.009470	6.89e-07	0.901000
Eukaryotic Translation Initiation	58	4.42e-06	1.63e-04	0.37700	0.377000	0.009470	6.89e-07	0.901000
PI3K events in ERBB2 signaling	14	5.07e-02	1.82e-01	0.37700	-0.200000	0.319000	1.95e-01	0.038700
DAP12 signaling	25	5.05e-03	4.41e-02	0.37600	0.339000	0.162000	3.32e-03	0.161000
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	59	4.07e-06	1.63e-04	0.37600	0.352000	0.130000	2.90e-06	0.084900
Nonsense-Mediated Decay (NMD)	59	4.07e-06	1.63e-04	0.37600	0.352000	0.130000	2.90e-06	0.084900
Inhibition of DNA recombination at telomere	13	6.73e-02	2.23e-01	0.37200	0.344000	-0.141000	3.17e-02	0.378000
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	28	3.02e-03	3.27e-02	0.37200	0.343000	-0.143000	1.68e-03	0.189000
Metabolism of folate and pterines	14	5.62e-02	1.94e-01	0.37100	-0.130000	-0.347000	3.99e-01	0.024600
Interferon gamma signaling	61	3.65e-06	1.63e-04	0.37100	0.352000	-0.117000	2.07e-06	0.116000
Regulation of Complement cascade	31	1.72e-03	2.25e-02	0.37000	0.369000	-0.032900	3.79e-04	0.752000
PKA activation in glucagon signalling	16	3.73e-02	1.49e-01	0.37000	-0.364000	0.067100	1.17e-02	0.642000
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	30	2.19e-03	2.64e-02	0.37000	0.338000	0.151000	1.38e-03	0.153000
Adherens junctions interactions	13	6.95e-02	2.28e-01	0.37000	-0.251000	0.271000	1.17e-01	0.090800
Negative regulation of MET activity	17	3.11e-02	1.37e-01	0.36900	-0.244000	0.277000	8.23e-02	0.048100
Diseases of carbohydrate metabolism	22	1.20e-02	7.50e-02	0.36700	-0.261000	-0.258000	3.39e-02	0.036600
CASP8 activity is inhibited	10	1.34e-01	3.46e-01	0.36700	0.309000	0.198000	9.10e-02	0.278000
Dimerization of procaspase-8	10	1.34e-01	3.46e-01	0.36700	0.309000	0.198000	9.10e-02	0.278000
Regulation by c-FLIP	10	1.34e-01	3.46e-01	0.36700	0.309000	0.198000	9.10e-02	0.278000
Activation of RAC1	12	8.93e-02	2.68e-01	0.36700	-0.004030	0.366000	9.81e-01	0.028000
Frs2-mediated activation	11	1.10e-01	3.01e-01	0.36500	-0.242000	0.274000	1.64e-01	0.116000
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	7.62e-02	2.40e-01	0.36300	0.311000	-0.188000	5.24e-02	0.240000
Ribosomal scanning and start codon recognition	30	2.78e-03	3.08e-02	0.36200	0.327000	0.156000	1.95e-03	0.138000
Orc1 removal from chromatin	54	2.56e-05	8.03e-04	0.36200	0.362000	-0.014200	4.33e-06	0.857000
Signaling by Hippo	18	2.95e-02	1.36e-01	0.36100	-0.309000	0.187000	2.34e-02	0.169000
Signaling by FGFR4	27	5.22e-03	4.43e-02	0.36000	-0.210000	0.293000	5.87e-02	0.008540
Telomere Extension By Telomerase	18	3.08e-02	1.36e-01	0.36000	0.285000	0.219000	3.61e-02	0.108000
DNA Replication Pre-Initiation	66	3.01e-06	1.50e-04	0.35900	0.352000	-0.068900	7.53e-07	0.334000
Translesion synthesis by POLK	12	9.87e-02	2.85e-01	0.35900	0.342000	-0.107000	4.01e-02	0.521000
Gluconeogenesis	23	1.20e-02	7.50e-02	0.35900	-0.198000	-0.299000	9.98e-02	0.013100
DAP12 interactions	28	4.93e-03	4.41e-02	0.35600	0.297000	0.196000	6.47e-03	0.072400
Regulation of pyruvate dehydrogenase (PDH) complex	12	1.05e-01	2.94e-01	0.35400	-0.315000	-0.162000	5.89e-02	0.330000
Synthesis of PA	23	1.34e-02	7.84e-02	0.35400	-0.203000	-0.290000	9.21e-02	0.016000
Signaling by FGFR3 in disease	16	4.93e-02	1.78e-01	0.35400	-0.220000	0.277000	1.27e-01	0.055100
Signaling by FGFR3 point mutants in cancer	16	4.93e-02	1.78e-01	0.35400	-0.220000	0.277000	1.27e-01	0.055100
Base Excision Repair	37	1.02e-03	1.64e-02	0.35300	0.330000	-0.124000	5.16e-04	0.192000
TRAF3-dependent IRF activation pathway	13	8.92e-02	2.68e-01	0.35200	0.323000	-0.140000	4.39e-02	0.381000
Spry regulation of FGF signaling	12	1.08e-01	2.98e-01	0.35100	-0.250000	0.247000	1.34e-01	0.139000
G1/S Transition	106	3.69e-09	1.16e-06	0.35100	0.351000	0.003440	4.61e-10	0.951000
Negative regulation of FGFR3 signaling	19	3.02e-02	1.36e-01	0.35000	-0.298000	0.184000	2.44e-02	0.166000
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	10	1.59e-01	3.84e-01	0.35000	-0.143000	-0.320000	4.34e-01	0.080000
Translation initiation complex formation	29	5.02e-03	4.41e-02	0.35000	0.315000	0.151000	3.32e-03	0.159000
SCF(Skp2)-mediated degradation of p27/p21	46	2.25e-04	4.97e-03	0.34900	0.347000	-0.037800	4.63e-05	0.658000
Synthesis of IP2, IP, and Ins in the cytosol	13	9.33e-02	2.75e-01	0.34900	-0.340000	-0.078900	3.38e-02	0.622000
PI-3K cascade:FGFR1	12	1.13e-01	3.08e-01	0.34800	-0.321000	0.134000	5.42e-02	0.423000
CD209 (DC-SIGN) signaling	19	3.21e-02	1.40e-01	0.34800	0.037300	0.346000	7.79e-01	0.009100
Selective autophagy	46	2.50e-04	5.41e-03	0.34800	-0.255000	-0.236000	2.79e-03	0.005580
Physiological factors	11	1.37e-01	3.51e-01	0.34700	-0.325000	0.123000	6.24e-02	0.478000
Translesion synthesis by POLI	12	1.16e-01	3.14e-01	0.34600	0.320000	-0.132000	5.51e-02	0.430000
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	19	3.47e-02	1.46e-01	0.34300	-0.194000	0.283000	1.44e-01	0.032500
Translesion synthesis by REV1	11	1.44e-01	3.62e-01	0.34300	0.316000	-0.133000	7.00e-02	0.444000
Citric acid cycle (TCA cycle)	18	4.21e-02	1.61e-01	0.34300	-0.138000	0.313000	3.09e-01	0.021400
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	1.45e-01	3.62e-01	0.34200	0.340000	-0.037800	5.07e-02	0.828000
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	14	8.58e-02	2.61e-01	0.34200	0.095900	-0.328000	5.35e-01	0.033500
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	26	1.06e-02	7.01e-02	0.34200	0.335000	0.067500	3.10e-03	0.551000
Pre-NOTCH Processing in Golgi	14	8.69e-02	2.63e-01	0.34100	-0.085900	-0.330000	5.78e-01	0.032300
Sulfur amino acid metabolism	18	4.37e-02	1.66e-01	0.34100	-0.237000	-0.245000	8.17e-02	0.071700
MECP2 regulates neuronal receptors and channels	12	1.24e-01	3.29e-01	0.34100	0.289000	0.181000	8.32e-02	0.278000
Regulation of expression of SLITs and ROBOs	94	1.01e-07	1.16e-05	0.33900	0.333000	0.067200	2.62e-08	0.261000
PECAM1 interactions	11	1.52e-01	3.75e-01	0.33800	0.331000	-0.065500	5.72e-02	0.707000
Condensation of Prophase Chromosomes	10	1.82e-01	4.21e-01	0.33700	0.337000	-0.002220	6.47e-02	0.990000
Activation of gene expression by SREBF (SREBP)	39	1.35e-03	1.94e-02	0.33700	-0.315000	-0.121000	6.81e-04	0.193000
Uptake and function of anthrax toxins	11	1.55e-01	3.78e-01	0.33600	-0.334000	-0.039600	5.51e-02	0.820000
Caspase activation via Death Receptors in the presence of ligand	15	7.94e-02	2.46e-01	0.33600	0.146000	0.302000	3.27e-01	0.042600
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	5.66e-02	1.95e-01	0.33600	0.178000	-0.285000	2.05e-01	0.042200
Mitotic G1 phase and G1/S transition	121	1.67e-09	7.01e-07	0.33500	0.335000	-0.000496	2.05e-10	0.992000
Complement cascade	35	2.80e-03	3.08e-02	0.33500	0.327000	-0.074700	8.34e-04	0.445000
Assembly of the pre-replicative complex	52	1.63e-04	3.86e-03	0.33500	0.329000	-0.062800	4.13e-05	0.434000
Miscellaneous transport and binding events	18	4.87e-02	1.78e-01	0.33500	-0.331000	0.052300	1.52e-02	0.701000
Deadenylation of mRNA	20	3.53e-02	1.46e-01	0.33400	0.128000	0.309000	3.23e-01	0.016800
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	3.05e-02	1.36e-01	0.33300	-0.331000	0.037900	8.69e-03	0.764000
Energy dependent regulation of mTOR by LKB1-AMPK	25	1.58e-02	8.67e-02	0.33300	-0.331000	0.032200	4.15e-03	0.780000
ERBB2 Regulates Cell Motility	12	1.38e-01	3.53e-01	0.33200	-0.205000	0.261000	2.20e-01	0.118000
Diseases associated with N-glycosylation of proteins	16	7.58e-02	2.40e-01	0.32800	-0.323000	-0.055700	2.52e-02	0.700000
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	3.41e-02	1.44e-01	0.32800	-0.109000	0.309000	3.88e-01	0.014300
Misspliced GSK3beta mutants stabilize beta-catenin	14	1.07e-01	2.95e-01	0.32600	-0.294000	0.141000	5.66e-02	0.361000
S33 mutants of beta-catenin aren't phosphorylated	14	1.07e-01	2.95e-01	0.32600	-0.294000	0.141000	5.66e-02	0.361000
S37 mutants of beta-catenin aren't phosphorylated	14	1.07e-01	2.95e-01	0.32600	-0.294000	0.141000	5.66e-02	0.361000
S45 mutants of beta-catenin aren't phosphorylated	14	1.07e-01	2.95e-01	0.32600	-0.294000	0.141000	5.66e-02	0.361000
T41 mutants of beta-catenin aren't phosphorylated	14	1.07e-01	2.95e-01	0.32600	-0.294000	0.141000	5.66e-02	0.361000
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	14	1.07e-01	2.95e-01	0.32600	-0.294000	0.141000	5.66e-02	0.361000
Ion homeostasis	42	1.23e-03	1.81e-02	0.32600	-0.304000	0.119000	6.62e-04	0.181000
TRAF6 mediated IRF7 activation	15	9.18e-02	2.72e-01	0.32600	0.322000	0.048300	3.06e-02	0.746000
Signaling by FGFR2	49	4.61e-04	9.13e-03	0.32400	-0.147000	0.288000	7.45e-02	0.000489
Signaling by FGFR2 in disease	27	1.45e-02	8.27e-02	0.32300	-0.244000	0.212000	2.82e-02	0.056600
ERBB2 Activates PTK6 Signaling	10	2.08e-01	4.55e-01	0.32300	-0.160000	0.281000	3.82e-01	0.124000
Pyruvate metabolism	23	2.81e-02	1.32e-01	0.32200	-0.293000	-0.133000	1.49e-02	0.269000
Resolution of Abasic Sites (AP sites)	31	8.35e-03	6.06e-02	0.32100	0.290000	-0.137000	5.20e-03	0.186000
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	19	5.42e-02	1.89e-01	0.32000	0.308000	-0.087300	2.03e-02	0.510000
Antigen processing-Cross presentation	75	1.19e-05	3.94e-04	0.31800	0.312000	-0.064600	3.15e-06	0.334000
Regulation of FZD by ubiquitination	10	2.22e-01	4.71e-01	0.31700	-0.312000	0.057000	8.79e-02	0.755000
Recognition of DNA damage by PCNA-containing replication complex	21	4.27e-02	1.63e-01	0.31700	0.301000	-0.096700	1.68e-02	0.443000
Signaling by ERBB2 KD Mutants	22	3.70e-02	1.48e-01	0.31600	-0.126000	0.290000	3.05e-01	0.018700
Degradation of cysteine and homocysteine	10	2.29e-01	4.77e-01	0.31400	-0.180000	-0.257000	3.24e-01	0.159000
Acyl chain remodelling of PS	13	1.48e-01	3.66e-01	0.31300	-0.093100	-0.299000	5.61e-01	0.061900
Extension of Telomeres	41	2.45e-03	2.88e-02	0.31300	0.310000	-0.042600	5.94e-04	0.637000
Signaling by ERBB2 in Cancer	23	3.62e-02	1.47e-01	0.31000	-0.112000	0.289000	3.54e-01	0.016300
Calnexin/calreticulin cycle	16	9.98e-02	2.85e-01	0.31000	-0.310000	-0.010700	3.19e-02	0.941000
FGFR2 mutant receptor activation	17	8.68e-02	2.63e-01	0.31000	-0.296000	0.091100	3.47e-02	0.515000
Signaling by FGFR1	35	6.57e-03	5.19e-02	0.31000	-0.128000	0.282000	1.91e-01	0.003910
Cross-presentation of soluble exogenous antigens (endosomes)	41	2.81e-03	3.08e-02	0.30900	0.289000	-0.109000	1.36e-03	0.226000
Sialic acid metabolism	23	3.75e-02	1.49e-01	0.30900	-0.167000	-0.260000	1.66e-01	0.030900
Negative regulation of NOTCH4 signaling	42	2.51e-03	2.89e-02	0.30900	0.298000	-0.081000	8.45e-04	0.364000
Glycogen synthesis	10	2.40e-01	4.89e-01	0.30900	-0.289000	0.107000	1.13e-01	0.557000
Uptake and actions of bacterial toxins	24	3.29e-02	1.42e-01	0.30900	-0.233000	-0.203000	4.87e-02	0.085700
Translation of Replicase and Assembly of the Replication Transcription Complex	11	2.10e-01	4.55e-01	0.30800	-0.244000	-0.188000	1.61e-01	0.280000
PINK1-PRKN Mediated Mitophagy	13	1.58e-01	3.82e-01	0.30800	-0.071000	-0.300000	6.58e-01	0.061300
Nucleotide-like (purinergic) receptors	12	1.84e-01	4.21e-01	0.30700	0.245000	0.185000	1.41e-01	0.268000
Downstream signaling of activated FGFR3	18	7.91e-02	2.46e-01	0.30600	-0.195000	0.237000	1.53e-01	0.082200
DNA Damage Bypass	34	8.41e-03	6.07e-02	0.30600	0.296000	-0.079900	2.85e-03	0.420000
FRS-mediated FGFR1 signaling	13	1.61e-01	3.87e-01	0.30600	-0.257000	0.165000	1.08e-01	0.302000
EPHA-mediated growth cone collapse	13	1.62e-01	3.88e-01	0.30600	0.289000	-0.099900	7.15e-02	0.533000
HSF1 activation	19	7.11e-02	2.31e-01	0.30500	-0.273000	-0.135000	3.91e-02	0.307000
Regulation of activated PAK-2p34 by proteasome mediated degradation	38	5.19e-03	4.43e-02	0.30400	0.280000	-0.118000	2.82e-03	0.208000
Synthesis of DNA	97	1.67e-06	1.21e-04	0.30300	0.299000	-0.052700	3.82e-07	0.370000
Signaling by ERBB2 TMD/JMD mutants	19	7.29e-02	2.34e-01	0.30300	-0.133000	0.273000	3.17e-01	0.039800
Telomere Maintenance	50	1.04e-03	1.64e-02	0.30300	0.296000	-0.063600	2.93e-04	0.437000
Biosynthesis of specialized proresolving mediators (SPMs)	12	1.93e-01	4.33e-01	0.30200	0.280000	-0.113000	9.26e-02	0.497000
TGF-beta receptor signaling activates SMADs	22	4.89e-02	1.78e-01	0.30200	-0.279000	0.117000	2.36e-02	0.342000
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	4.85e-03	4.41e-02	0.30200	0.292000	-0.076500	1.60e-03	0.409000
p53-Independent DNA Damage Response	39	4.85e-03	4.41e-02	0.30200	0.292000	-0.076500	1.60e-03	0.409000
p53-Independent G1/S DNA damage checkpoint	39	4.85e-03	4.41e-02	0.30200	0.292000	-0.076500	1.60e-03	0.409000
Role of phospholipids in phagocytosis	27	2.52e-02	1.22e-01	0.30200	0.261000	-0.152000	1.91e-02	0.172000
Negative regulation of FGFR1 signaling	19	7.52e-02	2.39e-01	0.30100	-0.255000	0.161000	5.48e-02	0.224000
DNA Replication	104	8.19e-07	7.35e-05	0.30100	0.296000	-0.055700	1.98e-07	0.327000
Cyclin E associated events during G1/S transition	67	1.19e-04	2.94e-03	0.30100	0.300000	0.024600	2.26e-05	0.729000
Signaling by FGFR3	28	2.31e-02	1.14e-01	0.30000	-0.170000	0.247000	1.21e-01	0.023700
ER-Phagosome pathway	61	2.80e-04	5.86e-03	0.30000	0.297000	-0.041700	6.21e-05	0.574000
Cyclin A:Cdk2-associated events at S phase entry	69	1.06e-04	2.67e-03	0.29800	0.298000	-0.001840	1.89e-05	0.979000
G2/M Checkpoints	107	7.83e-07	7.35e-05	0.29700	0.297000	-0.016600	1.20e-07	0.767000
Regulation of MECP2 expression and activity	26	3.35e-02	1.42e-01	0.29500	-0.261000	0.138000	2.14e-02	0.223000
Interferon Signaling	130	4.94e-08	6.89e-06	0.29500	0.286000	-0.073100	1.94e-08	0.151000
GPVI-mediated activation cascade	27	3.00e-02	1.36e-01	0.29500	0.294000	-0.019700	8.23e-03	0.859000
Blood group systems biosynthesis	10	2.74e-01	5.29e-01	0.29400	-0.224000	-0.191000	2.20e-01	0.296000
Signaling by ERBB2 ECD mutants	15	1.43e-01	3.61e-01	0.29400	-0.116000	0.270000	4.37e-01	0.070000
AMER1 mutants destabilize the destruction complex	13	1.85e-01	4.21e-01	0.29400	-0.265000	0.127000	9.81e-02	0.428000
APC truncation mutants have impaired AXIN binding	13	1.85e-01	4.21e-01	0.29400	-0.265000	0.127000	9.81e-02	0.428000
AXIN missense mutants destabilize the destruction complex	13	1.85e-01	4.21e-01	0.29400	-0.265000	0.127000	9.81e-02	0.428000
AXIN mutants destabilize the destruction complex, activating WNT signaling	13	1.85e-01	4.21e-01	0.29400	-0.265000	0.127000	9.81e-02	0.428000
Truncations of AMER1 destabilize the destruction complex	13	1.85e-01	4.21e-01	0.29400	-0.265000	0.127000	9.81e-02	0.428000
truncated APC mutants destabilize the destruction complex	13	1.85e-01	4.21e-01	0.29400	-0.265000	0.127000	9.81e-02	0.428000
Interleukin-2 signaling	10	2.78e-01	5.36e-01	0.29200	-0.008920	-0.292000	9.61e-01	0.110000
ER Quality Control Compartment (ERQC)	13	1.91e-01	4.32e-01	0.29100	-0.286000	-0.055100	7.41e-02	0.731000
Ca-dependent events	33	1.59e-02	8.67e-02	0.28900	-0.250000	0.146000	1.31e-02	0.146000
Other interleukin signaling	17	1.19e-01	3.20e-01	0.28900	0.223000	-0.183000	1.11e-01	0.191000
Transcriptional regulation of granulopoiesis	26	3.89e-02	1.51e-01	0.28900	0.253000	-0.138000	2.54e-02	0.223000
Ubiquitin-dependent degradation of Cyclin D	40	6.98e-03	5.44e-02	0.28800	0.278000	-0.076000	2.38e-03	0.406000
S Phase	135	6.13e-08	7.70e-06	0.28800	0.288000	0.005320	8.28e-09	0.915000
NCAM1 interactions	27	3.65e-02	1.47e-01	0.28700	-0.219000	-0.185000	4.92e-02	0.096200
Regulation of cholesterol biosynthesis by SREBP (SREBF)	50	2.19e-03	2.64e-02	0.28600	-0.279000	-0.065500	6.52e-04	0.424000
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	35	1.39e-02	7.99e-02	0.28600	-0.258000	-0.123000	8.21e-03	0.209000
Metabolism of polyamines	49	2.49e-03	2.89e-02	0.28600	0.278000	-0.065800	7.57e-04	0.426000
Nucleobase biosynthesis	13	2.06e-01	4.53e-01	0.28500	0.037100	-0.282000	8.17e-01	0.078000
TP53 Regulates Transcription of Death Receptors and Ligands	11	2.62e-01	5.15e-01	0.28500	-0.050700	0.280000	7.71e-01	0.108000
ROS and RNS production in phagocytes	26	4.36e-02	1.66e-01	0.28300	0.199000	-0.202000	7.96e-02	0.074600
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	4.39e-02	1.66e-01	0.28300	-0.281000	0.036400	1.32e-02	0.748000
Regulation of TNFR1 signaling	25	4.95e-02	1.79e-01	0.28300	0.271000	-0.081800	1.90e-02	0.479000
Interleukin-12 signaling	30	2.81e-02	1.32e-01	0.28200	0.274000	0.066500	9.35e-03	0.529000
ATF4 activates genes in response to endoplasmic reticulum stress	22	7.33e-02	2.34e-01	0.28200	0.265000	0.097300	3.18e-02	0.430000
Peroxisomal lipid metabolism	23	6.50e-02	2.18e-01	0.28100	0.164000	-0.229000	1.74e-01	0.057500
Prostacyclin signalling through prostacyclin receptor	11	2.72e-01	5.28e-01	0.28100	0.153000	-0.235000	3.79e-01	0.177000
Regulation of TP53 Activity through Association with Co-factors	12	2.45e-01	4.96e-01	0.28000	-0.260000	-0.103000	1.19e-01	0.536000
CDT1 association with the CDC6:ORC:origin complex	44	5.82e-03	4.73e-02	0.28000	0.269000	-0.076200	2.03e-03	0.382000
Transcriptional regulation of pluripotent stem cells	14	1.96e-01	4.40e-01	0.27900	-0.278000	-0.006900	7.13e-02	0.964000
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	7.01e-02	2.30e-01	0.27800	-0.075800	0.267000	5.29e-01	0.026600
Signaling by FGFR3 fusions in cancer	10	3.15e-01	5.64e-01	0.27800	-0.071800	0.268000	6.94e-01	0.142000
Smooth Muscle Contraction	34	2.01e-02	1.05e-01	0.27700	0.275000	0.037500	5.58e-03	0.706000
EPHB-mediated forward signaling	30	3.22e-02	1.40e-01	0.27700	0.230000	0.155000	2.96e-02	0.143000
The role of GTSE1 in G2/M progression after G2 checkpoint	46	5.20e-03	4.43e-02	0.27600	0.236000	-0.144000	5.65e-03	0.092000
Glyoxylate metabolism and glycine degradation	21	9.14e-02	2.72e-01	0.27600	-0.172000	-0.216000	1.73e-01	0.086400
CaM pathway	31	2.90e-02	1.34e-01	0.27600	-0.256000	0.104000	1.38e-02	0.315000
Calmodulin induced events	31	2.90e-02	1.34e-01	0.27600	-0.256000	0.104000	1.38e-02	0.315000
Vif-mediated degradation of APOBEC3G	39	1.17e-02	7.44e-02	0.27600	0.263000	-0.084500	4.56e-03	0.361000
NOTCH2 Activation and Transmission of Signal to the Nucleus	13	2.27e-01	4.75e-01	0.27600	0.251000	-0.114000	1.17e-01	0.476000
PLC beta mediated events	47	4.80e-03	4.41e-02	0.27500	-0.235000	0.143000	5.30e-03	0.089600
Cell recruitment (pro-inflammatory response)	18	1.29e-01	3.39e-01	0.27500	0.169000	-0.217000	2.14e-01	0.111000
Purinergic signaling in leishmaniasis infection	18	1.29e-01	3.39e-01	0.27500	0.169000	-0.217000	2.14e-01	0.111000
CLEC7A (Dectin-1) induces NFAT activation	10	3.21e-01	5.66e-01	0.27500	0.002460	0.275000	9.89e-01	0.132000
Meiotic synapsis	24	6.65e-02	2.22e-01	0.27500	0.273000	-0.026900	2.05e-02	0.820000
Zinc transporters	10	3.23e-01	5.68e-01	0.27400	0.243000	-0.128000	1.84e-01	0.482000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	14	2.07e-01	4.53e-01	0.27400	0.270000	0.051100	8.09e-02	0.741000
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	11	2.91e-01	5.43e-01	0.27400	0.155000	0.226000	3.74e-01	0.194000
Metabolism of Angiotensinogen to Angiotensins	12	2.59e-01	5.11e-01	0.27400	-0.208000	0.178000	2.12e-01	0.286000
Inflammasomes	18	1.33e-01	3.46e-01	0.27400	0.274000	0.010300	4.46e-02	0.939000
Fanconi Anemia Pathway	22	8.46e-02	2.59e-01	0.27400	0.107000	-0.252000	3.84e-01	0.041000
Signaling by EGFR	42	9.01e-03	6.46e-02	0.27400	-0.170000	0.215000	5.70e-02	0.016200
Adenylate cyclase inhibitory pathway	14	2.09e-01	4.55e-01	0.27300	-0.179000	0.206000	2.46e-01	0.182000
Synthesis of substrates in N-glycan biosythesis	48	4.88e-03	4.41e-02	0.27300	-0.134000	-0.237000	1.08e-01	0.004480
Vpu mediated degradation of CD4	40	1.18e-02	7.44e-02	0.27200	0.258000	-0.087900	4.81e-03	0.337000
Heme biosynthesis	11	2.95e-01	5.47e-01	0.27200	-0.260000	-0.082200	1.36e-01	0.637000
Protein ubiquitination	41	1.07e-02	7.04e-02	0.27200	-0.098400	0.253000	2.76e-01	0.005010
Chemokine receptors bind chemokines	28	4.64e-02	1.74e-01	0.27100	0.179000	0.204000	1.02e-01	0.062200
Gastrin-CREB signalling pathway via PKC and MAPK	16	1.72e-01	4.08e-01	0.27100	-0.097300	0.253000	5.01e-01	0.080200
Downstream signaling of activated FGFR1	21	1.00e-01	2.85e-01	0.27000	-0.120000	0.242000	3.42e-01	0.054700
Myogenesis	21	1.00e-01	2.85e-01	0.27000	-0.194000	0.189000	1.25e-01	0.135000
Incretin synthesis, secretion, and inactivation	10	3.37e-01	5.83e-01	0.27000	0.053800	0.264000	7.68e-01	0.148000
Arachidonic acid metabolism	34	2.55e-02	1.23e-01	0.26900	0.269000	-0.002820	6.76e-03	0.977000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	60	1.60e-03	2.18e-02	0.26800	-0.169000	-0.209000	2.40e-02	0.005210
Activation of BAD and translocation to mitochondria	14	2.23e-01	4.72e-01	0.26800	0.232000	0.134000	1.33e-01	0.384000
Presynaptic depolarization and calcium channel opening	11	3.07e-01	5.57e-01	0.26800	-0.267000	-0.018500	1.25e-01	0.915000
Defective CFTR causes cystic fibrosis	43	1.02e-02	6.84e-02	0.26700	0.258000	-0.067100	3.39e-03	0.447000
Signaling by FGFR2 IIIa TM	12	2.79e-01	5.36e-01	0.26700	-0.245000	-0.106000	1.42e-01	0.526000
TRP channels	12	2.81e-01	5.38e-01	0.26600	0.239000	-0.116000	1.52e-01	0.487000
Signaling by FGFR	58	2.23e-03	2.67e-02	0.26500	-0.081200	0.253000	2.86e-01	0.000884
Beta-catenin phosphorylation cascade	16	1.85e-01	4.21e-01	0.26500	-0.223000	0.143000	1.23e-01	0.321000
Chromosome Maintenance	65	1.10e-03	1.69e-02	0.26500	0.264000	-0.023400	2.37e-04	0.745000
FCGR3A-mediated phagocytosis	59	2.09e-03	2.58e-02	0.26500	0.264000	-0.014500	4.53e-04	0.847000
Leishmania phagocytosis	59	2.09e-03	2.58e-02	0.26500	0.264000	-0.014500	4.53e-04	0.847000
Parasite infection	59	2.09e-03	2.58e-02	0.26500	0.264000	-0.014500	4.53e-04	0.847000
Cellular response to heat stress	72	5.43e-04	1.00e-02	0.26500	-0.262000	0.034300	1.21e-04	0.615000
The NLRP3 inflammasome	13	2.57e-01	5.08e-01	0.26400	0.168000	-0.203000	2.93e-01	0.204000
Autodegradation of the E3 ubiquitin ligase COP1	40	1.54e-02	8.62e-02	0.26400	0.244000	-0.101000	7.63e-03	0.271000
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	43	1.15e-02	7.44e-02	0.26300	0.254000	-0.071000	4.03e-03	0.421000
Stabilization of p53	43	1.16e-02	7.44e-02	0.26300	0.234000	-0.120000	7.95e-03	0.173000
Synaptic adhesion-like molecules	17	1.73e-01	4.09e-01	0.26300	-0.172000	-0.199000	2.21e-01	0.155000
Downregulation of TGF-beta receptor signaling	19	1.41e-01	3.58e-01	0.26200	-0.222000	0.139000	9.39e-02	0.294000
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	41	1.51e-02	8.49e-02	0.26100	0.240000	-0.103000	7.83e-03	0.253000
Mitophagy	19	1.44e-01	3.62e-01	0.26100	-0.155000	-0.210000	2.42e-01	0.113000
The role of Nef in HIV-1 replication and disease pathogenesis	25	7.77e-02	2.43e-01	0.26100	0.258000	-0.042900	2.58e-02	0.710000
MAP kinase activation	56	3.40e-03	3.50e-02	0.26000	-0.202000	0.164000	8.89e-03	0.033900
FGFR2 alternative splicing	18	1.61e-01	3.86e-01	0.26000	-0.019300	0.260000	8.87e-01	0.056500
Nicotinamide salvaging	12	2.98e-01	5.48e-01	0.26000	0.246000	0.082400	1.40e-01	0.621000
SCF-beta-TrCP mediated degradation of Emi1	43	1.31e-02	7.84e-02	0.26000	0.251000	-0.067500	4.48e-03	0.444000
Cyclin D associated events in G1	38	2.20e-02	1.11e-01	0.26000	0.197000	0.169000	3.54e-02	0.072500
G1 Phase	38	2.20e-02	1.11e-01	0.26000	0.197000	0.169000	3.54e-02	0.072500
Metalloprotease DUBs	16	2.00e-01	4.46e-01	0.25900	0.148000	0.213000	3.06e-01	0.140000
Receptor-type tyrosine-protein phosphatases	13	2.72e-01	5.28e-01	0.25800	-0.136000	0.220000	3.97e-01	0.170000
MicroRNA (miRNA) biogenesis	15	2.24e-01	4.72e-01	0.25800	-0.209000	-0.152000	1.61e-01	0.308000
Regulation of RUNX3 expression and activity	42	1.51e-02	8.49e-02	0.25800	0.214000	-0.144000	1.63e-02	0.107000
Aquaporin-mediated transport	33	3.74e-02	1.49e-01	0.25800	-0.256000	-0.031400	1.09e-02	0.755000
Glutathione synthesis and recycling	10	3.69e-01	6.15e-01	0.25800	-0.028400	-0.256000	8.76e-01	0.160000
Amino acid transport across the plasma membrane	22	1.15e-01	3.13e-01	0.25600	-0.107000	-0.233000	3.85e-01	0.058800
Infection with Mycobacterium tuberculosis	21	1.28e-01	3.38e-01	0.25600	0.147000	0.209000	2.43e-01	0.096800
Signaling by TGFB family members	76	6.00e-04	1.09e-02	0.25600	-0.194000	0.166000	3.46e-03	0.012400
MAP3K8 (TPL2)-dependent MAPK1/3 activation	12	3.09e-01	5.58e-01	0.25500	-0.123000	0.224000	4.62e-01	0.179000
Hh mutants abrogate ligand secretion	43	1.52e-02	8.53e-02	0.25500	0.229000	-0.111000	9.30e-03	0.207000
SHC-mediated cascade:FGFR3	12	3.12e-01	5.61e-01	0.25400	-0.152000	0.203000	3.61e-01	0.222000
Regulation of HSF1-mediated heat shock response	56	4.59e-03	4.39e-02	0.25400	-0.218000	0.129000	4.80e-03	0.094400
G-protein mediated events	48	9.88e-03	6.69e-02	0.25400	-0.214000	0.136000	1.05e-02	0.102000
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	10	3.82e-01	6.29e-01	0.25300	0.244000	0.068700	1.82e-01	0.707000
DAG and IP3 signaling	37	2.85e-02	1.34e-01	0.25300	-0.229000	0.107000	1.58e-02	0.259000
IKK complex recruitment mediated by RIP1	15	2.36e-01	4.87e-01	0.25300	-0.019600	0.253000	8.96e-01	0.090400
Other semaphorin interactions	18	1.78e-01	4.17e-01	0.25300	0.147000	0.206000	2.81e-01	0.130000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	3.84e-01	6.31e-01	0.25200	0.168000	-0.188000	3.58e-01	0.303000
Olfactory Signaling Pathway	13	2.90e-01	5.42e-01	0.25200	-0.035100	0.250000	8.27e-01	0.119000
RET signaling	33	4.47e-02	1.69e-01	0.25100	-0.244000	-0.059000	1.53e-02	0.558000
Switching of origins to a post-replicative state	72	1.16e-03	1.73e-02	0.25100	0.250000	-0.021300	2.48e-04	0.755000
SUMOylation of DNA methylation proteins	15	2.45e-01	4.96e-01	0.25000	-0.128000	-0.215000	3.91e-01	0.149000
Dual Incision in GG-NER	33	4.64e-02	1.74e-01	0.24900	0.166000	-0.185000	9.83e-02	0.065400
VLDLR internalisation and degradation	11	3.61e-01	6.07e-01	0.24800	0.178000	-0.174000	3.07e-01	0.319000
PERK regulates gene expression	25	9.97e-02	2.85e-01	0.24800	0.190000	0.161000	1.01e-01	0.165000
G1/S DNA Damage Checkpoints	53	7.63e-03	5.67e-02	0.24800	0.238000	-0.068800	2.71e-03	0.387000
RUNX1 regulates transcription of genes involved in differentiation of HSCs	56	5.88e-03	4.73e-02	0.24800	0.233000	-0.083000	2.54e-03	0.283000
Glycogen metabolism	21	1.46e-01	3.63e-01	0.24700	-0.240000	-0.058700	5.66e-02	0.641000
Cardiac conduction	97	1.50e-04	3.63e-03	0.24700	-0.243000	0.042200	3.59e-05	0.473000
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	77	9.71e-04	1.64e-02	0.24600	0.227000	-0.094200	5.86e-04	0.154000
Mitochondrial calcium ion transport	16	2.38e-01	4.88e-01	0.24500	-0.185000	-0.161000	2.01e-01	0.266000
Insulin processing	19	1.83e-01	4.21e-01	0.24400	-0.219000	0.109000	9.91e-02	0.413000
Activation of NMDA receptors and postsynaptic events	63	3.66e-03	3.71e-02	0.24400	-0.149000	0.193000	4.06e-02	0.008130
Transport of vitamins, nucleosides, and related molecules	26	9.85e-02	2.85e-01	0.24400	0.193000	-0.150000	8.93e-02	0.187000
Role of LAT2/NTAL/LAB on calcium mobilization	14	2.88e-01	5.41e-01	0.24400	0.117000	0.214000	4.48e-01	0.166000
Interleukin-17 signaling	60	4.91e-03	4.41e-02	0.24300	-0.197000	0.143000	8.39e-03	0.055600
p53-Dependent G1 DNA Damage Response	51	1.11e-02	7.21e-02	0.24300	0.226000	-0.089900	5.34e-03	0.267000
p53-Dependent G1/S DNA damage checkpoint	51	1.11e-02	7.21e-02	0.24300	0.226000	-0.089900	5.34e-03	0.267000
Synthesis of PIPs at the late endosome membrane	10	4.16e-01	6.60e-01	0.24200	0.002480	0.242000	9.89e-01	0.185000
Mitochondrial tRNA aminoacylation	15	2.70e-01	5.27e-01	0.24200	-0.226000	-0.085000	1.30e-01	0.569000
Regulation of Apoptosis	40	3.06e-02	1.36e-01	0.24100	0.228000	-0.079300	1.27e-02	0.386000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	24	1.24e-01	3.29e-01	0.24100	-0.234000	-0.057900	4.72e-02	0.624000
Erythropoietin activates RAS	12	3.55e-01	6.01e-01	0.24000	0.057300	0.233000	7.31e-01	0.162000
RHO GTPases activate PAKs	21	1.63e-01	3.91e-01	0.24000	0.239000	-0.022000	5.81e-02	0.862000
Influenza Viral RNA Transcription and Replication	69	2.82e-03	3.08e-02	0.23900	0.235000	0.042200	7.40e-04	0.545000
MAPK targets/ Nuclear events mediated by MAP kinases	30	7.71e-02	2.42e-01	0.23900	-0.152000	0.184000	1.51e-01	0.080600
Macroautophagy	91	4.72e-04	9.13e-03	0.23800	-0.208000	-0.116000	6.35e-04	0.055400
Assembly and cell surface presentation of NMDA receptors	17	2.37e-01	4.87e-01	0.23800	-0.116000	0.207000	4.07e-01	0.139000
Regulation of RAS by GAPs	54	1.06e-02	7.01e-02	0.23800	0.236000	0.029900	2.76e-03	0.704000
Pyruvate metabolism and Citric Acid (TCA) cycle	42	2.89e-02	1.34e-01	0.23800	-0.231000	0.054300	9.57e-03	0.543000
Processing of SMDT1	11	3.95e-01	6.40e-01	0.23700	-0.123000	-0.203000	4.82e-01	0.243000
Free fatty acids regulate insulin secretion	10	4.32e-01	6.75e-01	0.23700	-0.237000	-0.001830	1.95e-01	0.992000
RNA Polymerase II Transcription Termination	49	1.69e-02	9.12e-02	0.23600	0.167000	0.168000	4.35e-02	0.042700
TCR signaling	89	6.15e-04	1.10e-02	0.23600	0.234000	0.032800	1.39e-04	0.594000
Transcriptional Regulation by MECP2	43	2.93e-02	1.35e-01	0.23400	-0.160000	0.171000	6.95e-02	0.052700
Post NMDA receptor activation events	54	1.22e-02	7.58e-02	0.23300	-0.196000	0.127000	1.30e-02	0.106000
Adenylate cyclase activating pathway	10	4.43e-01	6.83e-01	0.23300	-0.231000	0.031100	2.06e-01	0.865000
Depolymerisation of the Nuclear Lamina	14	3.20e-01	5.66e-01	0.23300	0.171000	-0.158000	2.67e-01	0.306000
rRNA processing in the nucleus and cytosol	118	7.45e-05	1.95e-03	0.23300	0.230000	-0.036800	1.68e-05	0.491000
E3 ubiquitin ligases ubiquitinate target proteins	25	1.32e-01	3.46e-01	0.23200	-0.041500	0.229000	7.20e-01	0.047900
Respiratory electron transport	69	3.95e-03	3.90e-02	0.23200	0.206000	0.106000	3.08e-03	0.127000
Interleukin-15 signaling	13	3.52e-01	6.01e-01	0.23200	-0.228000	-0.042000	1.55e-01	0.793000
Reproduction	52	1.59e-02	8.67e-02	0.23100	0.213000	-0.088300	7.86e-03	0.271000
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	22	1.74e-01	4.09e-01	0.23000	-0.225000	0.048600	6.77e-02	0.693000
YAP1- and WWTR1 (TAZ)-stimulated gene expression	14	3.29e-01	5.75e-01	0.23000	-0.198000	0.118000	2.00e-01	0.446000
SUMOylation of transcription factors	14	3.30e-01	5.75e-01	0.23000	0.016900	-0.229000	9.13e-01	0.137000
Diseases of programmed cell death	18	2.40e-01	4.90e-01	0.23000	0.126000	-0.192000	3.56e-01	0.158000
Regulation of ornithine decarboxylase (ODC)	42	3.62e-02	1.47e-01	0.23000	0.216000	-0.077000	1.53e-02	0.388000
Striated Muscle Contraction	29	1.01e-01	2.87e-01	0.23000	0.191000	-0.128000	7.54e-02	0.234000
Vasopressin regulates renal water homeostasis via Aquaporins	30	9.57e-02	2.80e-01	0.22900	-0.228000	0.015600	3.07e-02	0.883000
Autophagy	102	3.70e-04	7.62e-03	0.22800	-0.201000	-0.108000	4.56e-04	0.059900
Integration of energy metabolism	85	1.37e-03	1.96e-02	0.22800	-0.208000	-0.094600	9.45e-04	0.132000
Glutamate binding, activation of AMPA receptors and synaptic plasticity	25	1.43e-01	3.62e-01	0.22800	-0.160000	-0.163000	1.68e-01	0.159000
Trafficking of AMPA receptors	25	1.43e-01	3.62e-01	0.22800	-0.160000	-0.163000	1.68e-01	0.159000
Fcgamma receptor (FCGR) dependent phagocytosis	84	1.50e-03	2.11e-02	0.22800	0.215000	-0.075700	6.75e-04	0.231000
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	4.25e-01	6.68e-01	0.22800	-0.228000	-0.004710	1.91e-01	0.978000
Elevation of cytosolic Ca2+ levels	10	4.60e-01	6.92e-01	0.22800	-0.032600	-0.225000	8.58e-01	0.217000
Keratinization	21	1.96e-01	4.40e-01	0.22800	-0.044100	-0.223000	7.26e-01	0.076600
rRNA processing	125	6.73e-05	1.84e-03	0.22700	0.225000	-0.036000	1.51e-05	0.488000
COPI-independent Golgi-to-ER retrograde traffic	30	9.79e-02	2.84e-01	0.22700	-0.213000	0.080900	4.40e-02	0.444000
Phase II - Conjugation of compounds	64	7.32e-03	5.60e-02	0.22700	0.179000	0.140000	1.35e-02	0.052600
Nucleotide salvage	18	2.48e-01	5.01e-01	0.22700	0.211000	-0.084900	1.22e-01	0.533000
Processing of Capped Intronless Pre-mRNA	19	2.31e-01	4.78e-01	0.22700	0.038300	0.224000	7.73e-01	0.091300
Cellular hexose transport	11	4.28e-01	6.70e-01	0.22700	-0.068600	-0.216000	6.93e-01	0.214000
Signal regulatory protein family interactions	13	3.67e-01	6.13e-01	0.22700	0.014600	0.226000	9.27e-01	0.158000
Signaling by FGFR1 in disease	30	9.88e-02	2.85e-01	0.22700	-0.186000	0.130000	7.78e-02	0.219000
NGF-stimulated transcription	33	7.91e-02	2.46e-01	0.22700	-0.225000	-0.031400	2.57e-02	0.755000
KSRP (KHSRP) binds and destabilizes mRNA	15	3.15e-01	5.64e-01	0.22600	0.208000	-0.088600	1.62e-01	0.552000
ABC transporters in lipid homeostasis	12	3.99e-01	6.43e-01	0.22600	-0.224000	-0.033600	1.80e-01	0.840000
APC/C:Cdc20 mediated degradation of mitotic proteins	61	9.61e-03	6.63e-02	0.22600	0.209000	-0.084100	4.70e-03	0.256000
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	61	9.61e-03	6.63e-02	0.22600	0.209000	-0.084100	4.70e-03	0.256000
Degradation of DVL	44	3.53e-02	1.46e-01	0.22500	0.204000	-0.096200	1.95e-02	0.270000
TBC/RABGAPs	35	7.12e-02	2.31e-01	0.22500	-0.203000	-0.097100	3.80e-02	0.321000
HDR through Homologous Recombination (HRR)	50	2.30e-02	1.14e-01	0.22500	0.210000	-0.078700	1.01e-02	0.336000
Repression of WNT target genes	11	4.36e-01	6.77e-01	0.22400	0.033500	-0.222000	8.47e-01	0.202000
Peptide hormone metabolism	50	2.33e-02	1.15e-01	0.22400	-0.137000	0.177000	9.33e-02	0.030300
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	74	4.04e-03	3.95e-02	0.22400	0.201000	0.098100	2.82e-03	0.145000
VxPx cargo-targeting to cilium	17	2.80e-01	5.36e-01	0.22400	-0.192000	0.115000	1.71e-01	0.413000
WNT ligand biogenesis and trafficking	11	4.39e-01	6.78e-01	0.22300	-0.090300	0.204000	6.04e-01	0.241000
RHO GTPases activate CIT	18	2.60e-01	5.13e-01	0.22300	0.166000	-0.149000	2.23e-01	0.273000
MyD88 cascade initiated on plasma membrane	70	5.52e-03	4.56e-02	0.22300	-0.200000	0.098900	3.88e-03	0.153000
Toll Like Receptor 10 (TLR10) Cascade	70	5.52e-03	4.56e-02	0.22300	-0.200000	0.098900	3.88e-03	0.153000
Toll Like Receptor 5 (TLR5) Cascade	70	5.52e-03	4.56e-02	0.22300	-0.200000	0.098900	3.88e-03	0.153000
Major pathway of rRNA processing in the nucleolus and cytosol	111	2.72e-04	5.80e-03	0.22300	0.218000	-0.045300	7.32e-05	0.410000
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	17	2.83e-01	5.39e-01	0.22300	0.107000	-0.195000	4.46e-01	0.163000
Neurodegenerative Diseases	17	2.83e-01	5.39e-01	0.22300	0.107000	-0.195000	4.46e-01	0.163000
RUNX2 regulates bone development	27	1.36e-01	3.51e-01	0.22200	-0.080400	0.207000	4.70e-01	0.062800
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	59	1.30e-02	7.84e-02	0.22200	0.209000	-0.073800	5.48e-03	0.327000
Purine salvage	10	4.79e-01	7.04e-01	0.22200	0.221000	-0.013700	2.26e-01	0.940000
Interleukin-12 family signaling	36	7.17e-02	2.31e-01	0.22100	0.221000	0.006180	2.17e-02	0.949000
Early Phase of HIV Life Cycle	10	4.81e-01	7.04e-01	0.22100	0.221000	-0.011800	2.27e-01	0.949000
Synthesis of PC	21	2.16e-01	4.65e-01	0.22100	-0.218000	0.035400	8.39e-02	0.779000
Constitutive Signaling by AKT1 E17K in Cancer	24	1.74e-01	4.09e-01	0.22100	-0.215000	-0.050500	6.85e-02	0.669000
Signaling by ROBO receptors	132	7.70e-05	1.97e-03	0.22000	0.201000	0.090600	7.22e-05	0.073000
MTOR signalling	35	7.97e-02	2.46e-01	0.22000	-0.219000	0.014000	2.48e-02	0.886000
Apoptotic factor-mediated response	12	4.22e-01	6.67e-01	0.21900	0.091500	-0.199000	5.83e-01	0.233000
Detoxification of Reactive Oxygen Species	26	1.56e-01	3.79e-01	0.21900	0.212000	0.054800	6.19e-02	0.629000
Regulation of actin dynamics for phagocytic cup formation	61	1.31e-02	7.84e-02	0.21800	0.212000	-0.052700	4.29e-03	0.477000
Formation of the cornified envelope	17	2.99e-01	5.48e-01	0.21800	-0.150000	-0.159000	2.86e-01	0.257000
Phase 0 - rapid depolarisation	30	1.19e-01	3.20e-01	0.21800	-0.216000	-0.031000	4.09e-02	0.769000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	31	1.11e-01	3.03e-01	0.21800	0.215000	0.033600	3.83e-02	0.747000
mRNA 3'-end processing	42	5.13e-02	1.82e-01	0.21800	0.163000	0.145000	6.85e-02	0.105000
Sema4D induced cell migration and growth-cone collapse	19	2.61e-01	5.13e-01	0.21700	0.008810	-0.217000	9.47e-01	0.101000
Assembly Of The HIV Virion	10	4.97e-01	7.14e-01	0.21600	-0.168000	-0.136000	3.58e-01	0.457000
Activation of Matrix Metalloproteinases	17	3.05e-01	5.56e-01	0.21600	-0.214000	-0.028600	1.27e-01	0.838000
Response of Mtb to phagocytosis	18	2.85e-01	5.41e-01	0.21600	0.094000	0.194000	4.90e-01	0.154000
COPII-mediated vesicle transport	52	2.78e-02	1.32e-01	0.21500	-0.214000	0.017900	7.64e-03	0.824000
Pausing and recovery of Tat-mediated HIV elongation	20	2.52e-01	5.03e-01	0.21500	0.048200	-0.209000	7.09e-01	0.106000
Tat-mediated HIV elongation arrest and recovery	20	2.52e-01	5.03e-01	0.21500	0.048200	-0.209000	7.09e-01	0.106000
Integrin cell surface interactions	51	3.01e-02	1.36e-01	0.21400	0.159000	-0.144000	4.97e-02	0.076400
Interleukin receptor SHC signaling	20	2.53e-01	5.04e-01	0.21400	0.115000	-0.181000	3.75e-01	0.162000
BBSome-mediated cargo-targeting to cilium	17	3.12e-01	5.60e-01	0.21400	-0.122000	0.176000	3.84e-01	0.210000
Processing of DNA double-strand break ends	50	3.30e-02	1.42e-01	0.21400	0.214000	0.002290	9.01e-03	0.978000
Glucose metabolism	69	9.27e-03	6.50e-02	0.21300	-0.191000	-0.095100	6.12e-03	0.172000
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	58	1.98e-02	1.04e-01	0.21300	0.199000	-0.074400	8.73e-03	0.328000
Constitutive Signaling by NOTCH1 HD Domain Mutants	10	5.09e-01	7.19e-01	0.21200	0.202000	-0.066300	2.70e-01	0.717000
Signaling by NOTCH1 HD Domain Mutants in Cancer	10	5.09e-01	7.19e-01	0.21200	0.202000	-0.066300	2.70e-01	0.717000
Transferrin endocytosis and recycling	22	2.26e-01	4.75e-01	0.21200	-0.186000	0.102000	1.31e-01	0.408000
Defects in vitamin and cofactor metabolism	14	3.90e-01	6.38e-01	0.21200	-0.208000	0.039800	1.78e-01	0.797000
mRNA decay by 3' to 5' exoribonuclease	12	4.47e-01	6.84e-01	0.21200	0.211000	-0.015300	2.06e-01	0.927000
Interleukin-20 family signaling	15	3.70e-01	6.15e-01	0.21000	-0.000251	-0.210000	9.99e-01	0.158000
Autodegradation of Cdh1 by Cdh1:APC/C	50	3.65e-02	1.47e-01	0.21000	0.170000	-0.125000	3.83e-02	0.128000
Plasma lipoprotein clearance	25	1.92e-01	4.33e-01	0.21000	0.138000	-0.158000	2.34e-01	0.171000
TNFR1-induced proapoptotic signaling	13	4.25e-01	6.68e-01	0.21000	0.201000	-0.060300	2.10e-01	0.707000
Degradation of AXIN	42	6.39e-02	2.15e-01	0.20900	0.192000	-0.082300	3.12e-02	0.356000
APC/C-mediated degradation of cell cycle proteins	72	9.25e-03	6.50e-02	0.20900	0.201000	-0.057100	3.26e-03	0.402000
Regulation of mitotic cell cycle	72	9.25e-03	6.50e-02	0.20900	0.201000	-0.057100	3.26e-03	0.402000
RHO GTPases Activate WASPs and WAVEs	34	1.10e-01	3.01e-01	0.20800	0.206000	0.031700	3.77e-02	0.749000
G2/M DNA damage checkpoint	51	3.69e-02	1.48e-01	0.20800	0.207000	0.019300	1.05e-02	0.812000
Phase 2 - plateau phase	16	3.55e-01	6.01e-01	0.20800	-0.206000	-0.026000	1.53e-01	0.857000
CDK-mediated phosphorylation and removal of Cdc6	58	2.43e-02	1.18e-01	0.20700	0.190000	-0.081200	1.22e-02	0.286000
FCERI mediated MAPK activation	28	1.66e-01	3.96e-01	0.20700	0.021200	0.206000	8.46e-01	0.059500
RMTs methylate histone arginines	29	1.57e-01	3.81e-01	0.20700	-0.080000	-0.191000	4.56e-01	0.075800
Surfactant metabolism	12	4.65e-01	6.92e-01	0.20700	-0.088200	-0.187000	5.97e-01	0.262000
E2F mediated regulation of DNA replication	18	3.17e-01	5.66e-01	0.20700	0.189000	0.083800	1.66e-01	0.538000
Regulation of TP53 Activity through Acetylation	27	1.78e-01	4.17e-01	0.20700	0.020700	-0.206000	8.53e-01	0.064700
HSP90 chaperone cycle for steroid hormone receptors (SHR)	31	1.38e-01	3.53e-01	0.20600	-0.199000	0.054300	5.51e-02	0.601000
Influenza Infection	83	5.30e-03	4.47e-02	0.20600	0.188000	0.083300	3.04e-03	0.190000
UCH proteinases	68	1.34e-02	7.84e-02	0.20600	0.194000	-0.069400	5.74e-03	0.323000
Homology Directed Repair	81	5.98e-03	4.79e-02	0.20600	0.193000	-0.072300	2.76e-03	0.261000
RAS processing	17	3.40e-01	5.88e-01	0.20600	0.017100	0.205000	9.03e-01	0.143000
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	77	7.72e-03	5.70e-02	0.20600	-0.165000	0.122000	1.23e-02	0.063800
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	7.08e-02	2.31e-01	0.20500	0.195000	-0.065600	2.93e-02	0.463000
DCC mediated attractive signaling	13	4.43e-01	6.83e-01	0.20500	0.171000	0.113000	2.87e-01	0.480000
Netrin-1 signaling	41	7.65e-02	2.41e-01	0.20500	-0.109000	0.173000	2.29e-01	0.054900
Regulation of APC/C activators between G1/S and early anaphase	65	1.75e-02	9.38e-02	0.20400	0.199000	-0.046500	5.62e-03	0.517000
ABC transporter disorders	52	3.91e-02	1.52e-01	0.20400	0.190000	-0.073700	1.76e-02	0.359000
Synthesis of PIPs at the early endosome membrane	15	3.93e-01	6.40e-01	0.20400	0.003750	0.204000	9.80e-01	0.172000
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	15	3.94e-01	6.40e-01	0.20300	0.197000	-0.050400	1.87e-01	0.735000
Trafficking of GluR2-containing AMPA receptors	14	4.22e-01	6.67e-01	0.20300	0.036700	-0.199000	8.12e-01	0.197000
Regulation of TP53 Activity through Methylation	11	5.09e-01	7.19e-01	0.20300	-0.093800	-0.180000	5.90e-01	0.302000
Budding and maturation of HIV virion	19	3.11e-01	5.60e-01	0.20300	-0.202000	-0.017500	1.28e-01	0.895000
Signaling by NOTCH4	65	1.91e-02	1.01e-01	0.20200	0.199000	-0.033800	5.54e-03	0.637000
tRNA Aminoacylation	20	2.97e-01	5.48e-01	0.20100	-0.196000	-0.047400	1.30e-01	0.714000
Aggrephagy	14	4.28e-01	6.70e-01	0.20100	-0.024800	-0.200000	8.72e-01	0.196000
Translesion Synthesis by POLH	11	5.14e-01	7.21e-01	0.20100	0.176000	-0.096100	3.11e-01	0.581000
Biosynthesis of DHA-derived SPMs	10	5.46e-01	7.43e-01	0.20100	0.179000	-0.090300	3.26e-01	0.621000
p130Cas linkage to MAPK signaling for integrins	12	4.84e-01	7.07e-01	0.20100	0.093400	-0.178000	5.75e-01	0.287000
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	4.86e-01	7.07e-01	0.20000	0.017900	-0.199000	9.15e-01	0.232000
Metal ion SLC transporters	17	3.62e-01	6.08e-01	0.20000	0.163000	-0.115000	2.44e-01	0.412000
Asparagine N-linked glycosylation	218	3.05e-06	1.50e-04	0.19900	-0.190000	-0.060100	1.53e-06	0.128000
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	49	5.56e-02	1.93e-01	0.19900	0.197000	-0.025600	1.72e-02	0.757000
FCERI mediated Ca+2 mobilization	26	2.18e-01	4.66e-01	0.19800	0.128000	0.151000	2.59e-01	0.182000
Hedgehog ligand biogenesis	46	6.72e-02	2.23e-01	0.19800	0.160000	-0.116000	6.00e-02	0.174000
Meiosis	43	8.17e-02	2.52e-01	0.19700	0.194000	-0.037800	2.81e-02	0.668000
Regulation of KIT signaling	16	3.94e-01	6.40e-01	0.19700	0.174000	0.093700	2.30e-01	0.517000
Mitochondrial Fatty Acid Beta-Oxidation	27	2.10e-01	4.55e-01	0.19700	0.194000	-0.030700	8.09e-02	0.782000
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	3.97e-01	6.42e-01	0.19600	0.189000	0.054200	1.91e-01	0.707000
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	3.97e-01	6.42e-01	0.19600	0.189000	0.054200	1.91e-01	0.707000
CS/DS degradation	10	5.61e-01	7.54e-01	0.19600	-0.008150	0.196000	9.64e-01	0.283000
RUNX2 regulates osteoblast differentiation	22	2.83e-01	5.39e-01	0.19600	-0.013300	0.195000	9.14e-01	0.113000
Sealing of the nuclear envelope (NE) by ESCRT-III	22	2.86e-01	5.41e-01	0.19500	-0.178000	-0.080300	1.49e-01	0.514000
Cell surface interactions at the vascular wall	96	4.45e-03	4.30e-02	0.19500	0.194000	0.013300	1.03e-03	0.823000
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	59	3.58e-02	1.47e-01	0.19400	0.163000	-0.106000	3.08e-02	0.159000
Circadian Clock	58	3.86e-02	1.51e-01	0.19400	-0.144000	0.129000	5.80e-02	0.088600
Triglyceride metabolism	22	2.95e-01	5.47e-01	0.19300	0.063900	0.182000	6.04e-01	0.140000
Retrograde transport at the Trans-Golgi-Network	41	1.03e-01	2.90e-01	0.19300	-0.030600	0.190000	7.35e-01	0.035200
MyD88 dependent cascade initiated on endosome	78	1.34e-02	7.84e-02	0.19200	-0.150000	0.120000	2.18e-02	0.067500
Toll Like Receptor 7/8 (TLR7/8) Cascade	78	1.34e-02	7.84e-02	0.19200	-0.150000	0.120000	2.18e-02	0.067500
Hyaluronan uptake and degradation	10	5.78e-01	7.57e-01	0.19100	0.151000	-0.117000	4.07e-01	0.523000
NRAGE signals death through JNK	54	5.34e-02	1.87e-01	0.19100	-0.132000	-0.138000	9.34e-02	0.080400
Basigin interactions	20	3.36e-01	5.83e-01	0.19100	0.158000	-0.107000	2.22e-01	0.409000
Metabolism of amino acids and derivatives	218	8.53e-06	2.98e-04	0.19000	0.137000	-0.132000	5.03e-04	0.000826
Cytochrome P450 - arranged by substrate type	29	2.10e-01	4.55e-01	0.19000	0.088800	0.168000	4.08e-01	0.118000
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	24	2.75e-01	5.31e-01	0.19000	0.156000	0.109000	1.87e-01	0.358000
Chondroitin sulfate biosynthesis	15	4.46e-01	6.84e-01	0.19000	0.169000	0.086600	2.58e-01	0.561000
Signaling by NTRK2 (TRKB)	21	3.23e-01	5.68e-01	0.18900	-0.102000	0.160000	4.18e-01	0.206000
FGFR1 mutant receptor activation	23	2.92e-01	5.44e-01	0.18900	-0.187000	0.029700	1.21e-01	0.805000
Formation of Fibrin Clot (Clotting Cascade)	15	4.51e-01	6.87e-01	0.18900	0.167000	0.087700	2.63e-01	0.556000
HIV elongation arrest and recovery	21	3.30e-01	5.75e-01	0.18800	0.088000	-0.166000	4.85e-01	0.189000
Pausing and recovery of HIV elongation	21	3.30e-01	5.75e-01	0.18800	0.088000	-0.166000	4.85e-01	0.189000
Synthesis of bile acids and bile salts	21	3.31e-01	5.76e-01	0.18800	-0.177000	-0.063800	1.62e-01	0.613000
Formation of the beta-catenin:TCF transactivating complex	28	2.31e-01	4.78e-01	0.18700	-0.128000	-0.137000	2.42e-01	0.210000
Late endosomal microautophagy	22	3.16e-01	5.64e-01	0.18700	-0.178000	-0.058700	1.49e-01	0.634000
SHC-mediated cascade:FGFR1	12	5.32e-01	7.37e-01	0.18700	-0.082800	0.168000	6.19e-01	0.314000
PI3K Cascade	30	2.08e-01	4.55e-01	0.18700	-0.185000	0.025900	7.92e-02	0.806000
Signaling by FGFR in disease	45	9.56e-02	2.80e-01	0.18700	-0.164000	0.088900	5.70e-02	0.303000
TNFR1-induced NFkappaB signaling pathway	24	2.87e-01	5.41e-01	0.18600	0.186000	0.015700	1.15e-01	0.894000
Deposition of new CENPA-containing nucleosomes at the centromere	17	4.14e-01	6.58e-01	0.18600	0.158000	0.098500	2.59e-01	0.482000
Nucleosome assembly	17	4.14e-01	6.58e-01	0.18600	0.158000	0.098500	2.59e-01	0.482000
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	5.10e-01	7.19e-01	0.18600	-0.171000	-0.074300	2.87e-01	0.643000
APC/C:Cdc20 mediated degradation of Securin	54	6.11e-02	2.07e-01	0.18600	0.159000	-0.096800	4.36e-02	0.219000
TICAM1, RIP1-mediated IKK complex recruitment	12	5.37e-01	7.38e-01	0.18600	-0.015800	0.185000	9.25e-01	0.267000
TP53 Regulates Transcription of Cell Cycle Genes	45	9.79e-02	2.84e-01	0.18600	0.174000	-0.065100	4.36e-02	0.450000
Reduction of cytosolic Ca++ levels	10	5.96e-01	7.71e-01	0.18600	-0.143000	0.118000	4.33e-01	0.519000
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	35	1.65e-01	3.94e-01	0.18500	-0.066900	0.173000	4.94e-01	0.077000
Kinesins	34	1.74e-01	4.09e-01	0.18500	0.128000	-0.134000	1.95e-01	0.178000
TNFR2 non-canonical NF-kB pathway	64	3.77e-02	1.49e-01	0.18500	0.183000	-0.030200	1.16e-02	0.677000
Processing of Intronless Pre-mRNAs	12	5.39e-01	7.39e-01	0.18500	-0.051000	0.178000	7.60e-01	0.286000
ER to Golgi Anterograde Transport	109	3.88e-03	3.90e-02	0.18500	-0.185000	-0.001640	8.62e-04	0.976000
Toll Like Receptor 9 (TLR9) Cascade	81	1.60e-02	8.71e-02	0.18500	-0.144000	0.116000	2.55e-02	0.071000
RAF activation	31	2.05e-01	4.53e-01	0.18500	-0.182000	0.034200	8.02e-02	0.742000
Synthesis of PIPs at the Golgi membrane	14	4.90e-01	7.07e-01	0.18400	-0.063900	0.173000	6.79e-01	0.262000
Sema4D in semaphorin signaling	22	3.27e-01	5.74e-01	0.18400	0.082000	-0.165000	5.06e-01	0.181000
PIWI-interacting RNA (piRNA) biogenesis	11	5.74e-01	7.57e-01	0.18400	-0.027300	-0.182000	8.75e-01	0.297000
RORA activates gene expression	17	4.24e-01	6.68e-01	0.18300	-0.183000	0.006360	1.91e-01	0.964000
Purine catabolism	16	4.47e-01	6.84e-01	0.18300	0.183000	0.011900	2.05e-01	0.934000
Gap-filling DNA repair synthesis and ligation in TC-NER	49	8.53e-02	2.60e-01	0.18300	0.183000	0.006180	2.66e-02	0.940000
Ras activation upon Ca2+ influx through NMDA receptor	15	4.70e-01	6.97e-01	0.18300	-0.031100	0.181000	8.35e-01	0.226000
Negative regulators of DDX58/IFIH1 signaling	24	3.00e-01	5.50e-01	0.18300	0.160000	-0.088700	1.75e-01	0.452000
WNT5A-dependent internalization of FZD4	14	4.96e-01	7.14e-01	0.18300	-0.038100	-0.179000	8.05e-01	0.247000
Glucagon-type ligand receptors	13	5.24e-01	7.32e-01	0.18200	0.032400	-0.179000	8.40e-01	0.264000
FOXO-mediated transcription of cell cycle genes	16	4.51e-01	6.87e-01	0.18200	-0.156000	0.094400	2.81e-01	0.514000
Nicotinate metabolism	21	3.54e-01	6.01e-01	0.18200	0.181000	0.018000	1.51e-01	0.886000
Carnitine metabolism	11	5.81e-01	7.59e-01	0.18200	-0.103000	-0.150000	5.54e-01	0.390000
Platelet sensitization by LDL	15	4.78e-01	7.04e-01	0.18200	-0.115000	-0.140000	4.41e-01	0.346000
Apoptotic cleavage of cellular proteins	31	2.19e-01	4.66e-01	0.18100	-0.115000	0.140000	2.68e-01	0.179000
SHC1 events in ERBB2 signaling	20	3.78e-01	6.25e-01	0.18000	-0.098000	0.151000	4.48e-01	0.242000
CD28 co-stimulation	32	2.12e-01	4.59e-01	0.18000	0.153000	0.094500	1.34e-01	0.355000
Tight junction interactions	10	6.18e-01	7.85e-01	0.18000	-0.116000	-0.137000	5.24e-01	0.454000
Glutamate Neurotransmitter Release Cycle	16	4.62e-01	6.92e-01	0.17900	0.016700	-0.179000	9.08e-01	0.216000
Signaling by cytosolic FGFR1 fusion mutants	18	4.20e-01	6.65e-01	0.17900	-0.170000	0.058300	2.13e-01	0.669000
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	15	4.86e-01	7.07e-01	0.17900	-0.036700	0.175000	8.06e-01	0.240000
Complex I biogenesis	39	1.55e-01	3.78e-01	0.17900	0.159000	0.082100	8.59e-02	0.375000
Downregulation of ERBB2 signaling	20	3.86e-01	6.34e-01	0.17800	-0.151000	0.093500	2.41e-01	0.469000
Signaling by Non-Receptor Tyrosine Kinases	43	1.31e-01	3.43e-01	0.17800	-0.031400	0.175000	7.22e-01	0.047300
Signaling by PTK6	43	1.31e-01	3.43e-01	0.17800	-0.031400	0.175000	7.22e-01	0.047300
Glucagon signaling in metabolic regulation	24	3.22e-01	5.67e-01	0.17800	-0.176000	0.025500	1.36e-01	0.829000
Assembly of active LPL and LIPC lipase complexes	11	5.94e-01	7.70e-01	0.17800	-0.171000	0.049200	3.27e-01	0.777000
tRNA modification in the nucleus and cytosol	31	2.31e-01	4.79e-01	0.17800	0.087000	-0.155000	4.02e-01	0.136000
Regulation of beta-cell development	20	3.92e-01	6.39e-01	0.17700	-0.143000	0.103000	2.68e-01	0.424000
TP53 Regulates Transcription of Cell Death Genes	34	2.06e-01	4.53e-01	0.17600	0.068900	0.162000	4.87e-01	0.101000
Acyl chain remodelling of PG	10	6.28e-01	7.92e-01	0.17600	-0.038600	-0.172000	8.33e-01	0.346000
Acyl chain remodelling of PC	17	4.55e-01	6.89e-01	0.17600	0.069700	-0.161000	6.19e-01	0.250000
Endosomal Sorting Complex Required For Transport (ESCRT)	22	3.67e-01	6.13e-01	0.17400	-0.171000	-0.034500	1.65e-01	0.780000
Interleukin-6 family signaling	17	4.61e-01	6.92e-01	0.17400	0.058800	-0.164000	6.75e-01	0.241000
HDACs deacetylate histones	26	3.06e-01	5.57e-01	0.17400	-0.025000	-0.173000	8.25e-01	0.128000
Pentose phosphate pathway	13	5.54e-01	7.48e-01	0.17400	0.173000	0.016200	2.79e-01	0.919000
Activation of SMO	13	5.55e-01	7.49e-01	0.17400	-0.091200	-0.148000	5.69e-01	0.355000
G beta:gamma signalling through BTK	10	6.35e-01	7.95e-01	0.17400	0.122000	-0.124000	5.05e-01	0.496000
Post-chaperonin tubulin folding pathway	17	4.64e-01	6.92e-01	0.17400	-0.082300	-0.153000	5.57e-01	0.275000
Peroxisomal protein import	47	1.20e-01	3.22e-01	0.17400	0.134000	-0.110000	1.12e-01	0.192000
IRS-mediated signalling	34	2.18e-01	4.66e-01	0.17300	-0.156000	0.074200	1.15e-01	0.454000
Purine ribonucleoside monophosphate biosynthesis	11	6.13e-01	7.83e-01	0.17200	0.065600	-0.159000	7.06e-01	0.360000
MyD88-independent TLR4 cascade	83	2.56e-02	1.23e-01	0.17200	-0.135000	0.107000	3.42e-02	0.092800
TRIF(TICAM1)-mediated TLR4 signaling	83	2.56e-02	1.23e-01	0.17200	-0.135000	0.107000	3.42e-02	0.092800
TNFs bind their physiological receptors	10	6.44e-01	8.00e-01	0.17100	0.170000	0.026000	3.53e-01	0.887000
Signaling by NTRKs	118	5.85e-03	4.73e-02	0.17100	-0.170000	0.020400	1.46e-03	0.703000
Signaling by NOTCH2	21	4.00e-01	6.44e-01	0.17100	0.157000	0.067700	2.14e-01	0.591000
Ub-specific processing proteases	151	1.51e-03	2.11e-02	0.17100	0.157000	0.067700	9.32e-04	0.152000
Cell-cell junction organization	25	3.37e-01	5.83e-01	0.17000	-0.147000	0.086400	2.04e-01	0.455000
NOD1/2 Signaling Pathway	27	3.10e-01	5.60e-01	0.17000	-0.042800	0.165000	7.00e-01	0.139000
Transport to the Golgi and subsequent modification	132	3.47e-03	3.55e-02	0.17000	-0.170000	0.004180	7.68e-04	0.934000
Metabolism of steroids	102	1.26e-02	7.71e-02	0.17000	-0.159000	-0.060900	5.72e-03	0.289000
Signaling by the B Cell Receptor (BCR)	97	1.59e-02	8.67e-02	0.17000	0.163000	0.045100	5.50e-03	0.443000
RAF-independent MAPK1/3 activation	21	4.05e-01	6.51e-01	0.16900	-0.169000	0.007540	1.79e-01	0.952000
NOTCH3 Activation and Transmission of Signal to the Nucleus	18	4.62e-01	6.92e-01	0.16900	0.156000	-0.064300	2.51e-01	0.637000
Voltage gated Potassium channels	24	3.58e-01	6.04e-01	0.16900	-0.139000	0.096300	2.40e-01	0.414000
Formation of tubulin folding intermediates by CCT/TriC	16	5.05e-01	7.19e-01	0.16900	-0.168000	0.020300	2.46e-01	0.888000
Glycolysis	54	1.01e-01	2.87e-01	0.16900	-0.163000	-0.044100	3.87e-02	0.576000
NIK-->noncanonical NF-kB signaling	45	1.48e-01	3.66e-01	0.16900	0.166000	-0.026200	5.35e-02	0.761000
Host Interactions of HIV factors	100	1.46e-02	8.29e-02	0.16900	0.167000	-0.025600	4.07e-03	0.658000
Biological oxidations	126	5.09e-03	4.41e-02	0.16800	0.130000	0.106000	1.17e-02	0.039800
Activated NOTCH1 Transmits Signal to the Nucleus	22	3.94e-01	6.40e-01	0.16800	0.055200	-0.159000	6.54e-01	0.197000
G beta:gamma signalling through PI3Kgamma	16	5.08e-01	7.19e-01	0.16800	0.103000	-0.132000	4.75e-01	0.359000
Cell Cycle Checkpoints	206	1.95e-04	4.36e-03	0.16800	0.167000	0.014000	3.79e-05	0.730000
NOTCH1 Intracellular Domain Regulates Transcription	40	1.85e-01	4.21e-01	0.16800	-0.131000	0.105000	1.52e-01	0.252000
Transport of inorganic cations/anions and amino acids/oligopeptides	69	5.61e-02	1.94e-01	0.16700	-0.136000	-0.097100	5.03e-02	0.164000
Platelet Aggregation (Plug Formation)	25	3.50e-01	5.99e-01	0.16700	0.059600	-0.156000	6.06e-01	0.176000
Integrin signaling	24	3.66e-01	6.13e-01	0.16700	0.023300	-0.166000	8.43e-01	0.161000
Nuclear Events (kinase and transcription factor activation)	55	1.01e-01	2.87e-01	0.16700	-0.167000	0.002630	3.24e-02	0.973000
Extra-nuclear estrogen signaling	61	7.92e-02	2.46e-01	0.16700	0.010300	0.167000	8.89e-01	0.024600
G alpha (12/13) signalling events	65	6.77e-02	2.24e-01	0.16700	-0.098200	-0.135000	1.72e-01	0.060400
Transport of Mature mRNA derived from an Intron-Containing Transcript	55	1.03e-01	2.91e-01	0.16600	0.142000	0.087400	6.95e-02	0.263000
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	81	3.54e-02	1.46e-01	0.16600	-0.131000	0.102000	4.18e-02	0.112000
Toll Like Receptor 2 (TLR2) Cascade	81	3.54e-02	1.46e-01	0.16600	-0.131000	0.102000	4.18e-02	0.112000
Toll Like Receptor TLR1:TLR2 Cascade	81	3.54e-02	1.46e-01	0.16600	-0.131000	0.102000	4.18e-02	0.112000
Toll Like Receptor TLR6:TLR2 Cascade	81	3.54e-02	1.46e-01	0.16600	-0.131000	0.102000	4.18e-02	0.112000
Tie2 Signaling	15	5.37e-01	7.38e-01	0.16600	-0.068500	0.151000	6.46e-01	0.310000
Presynaptic phase of homologous DNA pairing and strand exchange	32	2.68e-01	5.24e-01	0.16600	0.166000	-0.001040	1.05e-01	0.992000
Transcriptional regulation by RUNX3	80	3.80e-02	1.50e-01	0.16500	0.132000	-0.099700	4.15e-02	0.124000
FOXO-mediated transcription of cell death genes	13	5.87e-01	7.65e-01	0.16500	-0.165000	-0.013000	3.03e-01	0.935000
Cargo recognition for clathrin-mediated endocytosis	74	4.92e-02	1.78e-01	0.16500	-0.151000	0.067400	2.52e-02	0.317000
Caspase activation via extrinsic apoptotic signalling pathway	22	4.08e-01	6.51e-01	0.16500	0.033300	0.162000	7.87e-01	0.189000
Ion transport by P-type ATPases	35	2.42e-01	4.92e-01	0.16500	-0.147000	0.073900	1.32e-01	0.450000
LDL clearance	16	5.22e-01	7.31e-01	0.16500	0.057500	-0.154000	6.91e-01	0.286000
Transcriptional Regulation by E2F6	30	2.98e-01	5.48e-01	0.16400	0.163000	0.022700	1.23e-01	0.830000
Cell death signalling via NRAGE, NRIF and NADE	63	7.97e-02	2.46e-01	0.16400	-0.085500	-0.140000	2.41e-01	0.054700
MAP2K and MAPK activation	31	2.86e-01	5.41e-01	0.16400	0.163000	-0.018200	1.16e-01	0.861000
Intra-Golgi traffic	34	2.54e-01	5.04e-01	0.16400	-0.084100	0.141000	3.96e-01	0.156000
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	4.85e-01	7.07e-01	0.16400	-0.115000	-0.117000	3.97e-01	0.392000
Apoptotic execution phase	38	2.16e-01	4.65e-01	0.16400	-0.099700	0.130000	2.88e-01	0.165000
Retrograde neurotrophin signalling	13	5.93e-01	7.70e-01	0.16400	-0.155000	-0.053900	3.34e-01	0.736000
GLI3 is processed to GLI3R by the proteasome	46	1.58e-01	3.82e-01	0.16400	0.164000	-0.000326	5.48e-02	0.997000
Degradation of GLI1 by the proteasome	47	1.52e-01	3.74e-01	0.16400	0.163000	-0.012000	5.29e-02	0.887000
IRS-related events triggered by IGF1R	37	2.27e-01	4.75e-01	0.16300	-0.133000	0.094600	1.61e-01	0.320000
Deactivation of the beta-catenin transactivating complex	30	3.02e-01	5.54e-01	0.16300	-0.153000	-0.057300	1.47e-01	0.587000
RNA Polymerase I Promoter Clearance	38	2.22e-01	4.71e-01	0.16300	-0.040000	-0.158000	6.70e-01	0.092400
Carboxyterminal post-translational modifications of tubulin	25	3.71e-01	6.16e-01	0.16300	0.024900	-0.161000	8.29e-01	0.164000
Potential therapeutics for SARS	32	2.82e-01	5.39e-01	0.16300	0.141000	0.081700	1.68e-01	0.424000
Abortive elongation of HIV-1 transcript in the absence of Tat	16	5.31e-01	7.37e-01	0.16300	-0.069600	-0.147000	6.30e-01	0.309000
CRMPs in Sema3A signaling	14	5.75e-01	7.57e-01	0.16300	0.155000	0.050000	3.17e-01	0.746000
Degradation of GLI2 by the proteasome	46	1.65e-01	3.93e-01	0.16200	0.161000	-0.020200	5.96e-02	0.812000
Dual incision in TC-NER	50	1.41e-01	3.58e-01	0.16200	0.156000	-0.041600	5.60e-02	0.612000
Binding and Uptake of Ligands by Scavenger Receptors	31	2.97e-01	5.48e-01	0.16200	0.029500	-0.159000	7.76e-01	0.126000
Signalling to ERKs	31	2.98e-01	5.48e-01	0.16100	-0.114000	0.114000	2.72e-01	0.271000
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	6.26e-01	7.91e-01	0.16100	-0.023400	0.160000	8.89e-01	0.338000
Thrombin signalling through proteinase activated receptors (PARs)	22	4.25e-01	6.68e-01	0.16100	0.000653	-0.161000	9.96e-01	0.191000
RNA Polymerase I Transcription	39	2.21e-01	4.71e-01	0.16100	-0.022500	-0.159000	8.08e-01	0.085200
Regulation of insulin secretion	58	1.07e-01	2.95e-01	0.16100	-0.156000	-0.040100	4.05e-02	0.598000
Toll Like Receptor 3 (TLR3) Cascade	79	4.81e-02	1.78e-01	0.16000	-0.130000	0.094300	4.64e-02	0.148000
RNA Polymerase I Transcription Initiation	35	2.62e-01	5.15e-01	0.16000	-0.055000	-0.150000	5.74e-01	0.124000
Negative regulation of NMDA receptor-mediated neuronal transmission	15	5.64e-01	7.56e-01	0.16000	-0.159000	0.014800	2.87e-01	0.921000
Thromboxane signalling through TP receptor	15	5.64e-01	7.56e-01	0.16000	0.006750	-0.159000	9.64e-01	0.285000
Downstream TCR signaling	69	7.33e-02	2.34e-01	0.15900	0.159000	-0.002740	2.23e-02	0.969000
AKT phosphorylates targets in the cytosol	13	6.10e-01	7.82e-01	0.15900	-0.101000	-0.124000	5.30e-01	0.440000
Opioid Signalling	71	6.80e-02	2.24e-01	0.15900	-0.141000	0.074100	4.03e-02	0.281000
Synthesis of very long-chain fatty acyl-CoAs	14	5.88e-01	7.65e-01	0.15900	-0.097900	0.125000	5.26e-01	0.417000
Class I peroxisomal membrane protein import	15	5.68e-01	7.56e-01	0.15900	0.091700	0.130000	5.39e-01	0.385000
Lysosome Vesicle Biogenesis	28	3.51e-01	6.00e-01	0.15800	0.016200	-0.157000	8.82e-01	0.150000
Mitochondrial biogenesis	67	8.30e-02	2.55e-01	0.15800	-0.147000	-0.057600	3.77e-02	0.416000
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	15	5.71e-01	7.57e-01	0.15800	-0.018400	0.157000	9.02e-01	0.293000
Dectin-1 mediated noncanonical NF-kB signaling	46	1.81e-01	4.21e-01	0.15800	0.154000	-0.032500	7.05e-02	0.703000
Peptide ligand-binding receptors	66	8.72e-02	2.63e-01	0.15800	0.087700	0.131000	2.18e-01	0.066300
Unfolded Protein Response (UPR)	75	6.49e-02	2.18e-01	0.15700	-0.125000	-0.094400	6.17e-02	0.158000
Costimulation by the CD28 family	53	1.45e-01	3.63e-01	0.15600	0.156000	-0.000283	4.96e-02	0.997000
Fatty acid metabolism	119	1.35e-02	7.84e-02	0.15600	0.135000	-0.077300	1.09e-02	0.146000
DNA Damage/Telomere Stress Induced Senescence	23	4.33e-01	6.75e-01	0.15600	0.156000	-0.005660	1.96e-01	0.963000
Signaling by ERBB2	38	2.52e-01	5.03e-01	0.15600	-0.110000	0.111000	2.43e-01	0.239000
Golgi Associated Vesicle Biogenesis	46	1.91e-01	4.31e-01	0.15500	-0.139000	0.068100	1.02e-01	0.425000
Insulin receptor signalling cascade	39	2.45e-01	4.96e-01	0.15500	-0.124000	0.092700	1.80e-01	0.317000
Downstream signaling events of B Cell Receptor (BCR)	67	9.14e-02	2.72e-01	0.15500	0.144000	0.057600	4.22e-02	0.415000
Signaling by TGF-beta Receptor Complex	57	1.31e-01	3.43e-01	0.15500	-0.129000	0.085000	9.24e-02	0.267000
Constitutive Signaling by Overexpressed ERBB2	10	6.99e-01	8.49e-01	0.15400	-0.065900	0.140000	7.18e-01	0.445000
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	5.28e-01	7.35e-01	0.15400	0.138000	-0.068800	3.13e-01	0.614000
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	28	3.75e-01	6.20e-01	0.15300	-0.142000	-0.056500	1.92e-01	0.605000
SUMOylation of DNA replication proteins	34	3.05e-01	5.56e-01	0.15300	0.152000	-0.017700	1.26e-01	0.858000
RNA Polymerase III Transcription Termination	18	5.33e-01	7.37e-01	0.15300	0.152000	-0.011600	2.63e-01	0.932000
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	21	4.80e-01	7.04e-01	0.15300	-0.139000	0.062400	2.69e-01	0.621000
Oxidative Stress Induced Senescence	55	1.47e-01	3.65e-01	0.15300	-0.151000	-0.022300	5.28e-02	0.775000
Glycerophospholipid biosynthesis	87	4.93e-02	1.78e-01	0.15300	-0.101000	-0.114000	1.04e-01	0.065800
Transport of bile salts and organic acids, metal ions and amine compounds	44	2.18e-01	4.66e-01	0.15200	0.152000	-0.007190	8.11e-02	0.934000
Cytosolic sensors of pathogen-associated DNA	47	1.97e-01	4.41e-01	0.15200	0.123000	-0.088700	1.44e-01	0.293000
Antiviral mechanism by IFN-stimulated genes	57	1.41e-01	3.58e-01	0.15200	0.151000	-0.013900	4.89e-02	0.856000
Ion channel transport	100	3.32e-02	1.42e-01	0.15100	-0.134000	0.070500	2.11e-02	0.224000
SARS-CoV-1 Infection	36	2.93e-01	5.44e-01	0.15100	-0.150000	-0.017200	1.19e-01	0.858000
Meiotic recombination	21	4.87e-01	7.07e-01	0.15100	0.122000	-0.088900	3.33e-01	0.481000
Syndecan interactions	17	5.60e-01	7.54e-01	0.15100	-0.014600	-0.150000	9.17e-01	0.284000
Cargo concentration in the ER	20	5.06e-01	7.19e-01	0.15100	-0.148000	-0.029000	2.52e-01	0.823000
Negative regulation of MAPK pathway	37	2.87e-01	5.41e-01	0.15000	-0.147000	0.029800	1.21e-01	0.754000
Stimuli-sensing channels	51	1.79e-01	4.19e-01	0.15000	-0.124000	0.084600	1.26e-01	0.296000
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	6.45e-01	8.00e-01	0.15000	0.071000	-0.132000	6.57e-01	0.410000
DARPP-32 events	21	4.94e-01	7.11e-01	0.15000	-0.132000	0.070100	2.94e-01	0.578000
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	34	3.21e-01	5.66e-01	0.15000	-0.007380	-0.149000	9.41e-01	0.132000
Notch-HLH transcription pathway	24	4.50e-01	6.87e-01	0.14900	-0.087000	-0.121000	4.61e-01	0.304000
Neutrophil degranulation	336	1.85e-05	5.96e-04	0.14900	0.139000	-0.054100	1.38e-05	0.090800
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	11	6.93e-01	8.45e-01	0.14900	-0.041700	0.143000	8.11e-01	0.412000
RHO GTPases activate IQGAPs	10	7.18e-01	8.61e-01	0.14900	0.039900	0.143000	8.27e-01	0.432000
Nucleobase catabolism	28	3.95e-01	6.40e-01	0.14900	0.142000	0.044800	1.94e-01	0.682000
Defective B3GALT6 causes EDSP2 and SEMDJL1	15	6.08e-01	7.81e-01	0.14900	0.049600	0.140000	7.40e-01	0.347000
HS-GAG degradation	17	5.68e-01	7.56e-01	0.14900	0.042400	-0.143000	7.62e-01	0.309000
HDR through Single Strand Annealing (SSA)	31	3.58e-01	6.04e-01	0.14900	0.107000	-0.103000	3.02e-01	0.321000
mRNA Splicing - Major Pathway	133	1.31e-02	7.84e-02	0.14800	0.137000	0.056700	6.45e-03	0.260000
Triglyceride catabolism	14	6.30e-01	7.93e-01	0.14800	0.008780	0.148000	9.55e-01	0.337000
Metabolism of porphyrins	19	5.36e-01	7.38e-01	0.14800	-0.070000	-0.131000	5.98e-01	0.325000
DNA Double-Strand Break Repair	104	3.45e-02	1.45e-01	0.14700	0.127000	-0.074400	2.52e-02	0.191000
IL-6-type cytokine receptor ligand interactions	11	6.99e-01	8.49e-01	0.14700	0.071900	-0.129000	6.80e-01	0.460000
Signaling by NTRK1 (TRKA)	103	3.62e-02	1.47e-01	0.14700	-0.146000	0.017600	1.05e-02	0.758000
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	1.98e-01	4.42e-01	0.14700	-0.134000	0.060700	1.01e-01	0.458000
Response of EIF2AK1 (HRI) to heme deficiency	12	6.79e-01	8.33e-01	0.14700	0.074300	0.127000	6.56e-01	0.448000
Acyl chain remodelling of PE	15	6.17e-01	7.85e-01	0.14600	0.021800	-0.145000	8.84e-01	0.332000
Branched-chain amino acid catabolism	19	5.44e-01	7.41e-01	0.14600	-0.143000	-0.029300	2.79e-01	0.825000
Resolution of D-Loop Structures	27	4.23e-01	6.67e-01	0.14600	0.111000	-0.095100	3.21e-01	0.392000
Innate Immune System	699	8.48e-10	5.33e-07	0.14500	0.144000	-0.023200	1.79e-10	0.303000
BMAL1:CLOCK,NPAS2 activates circadian gene expression	22	5.00e-01	7.15e-01	0.14500	-0.120000	-0.082600	3.32e-01	0.503000
Homologous DNA Pairing and Strand Exchange	35	3.31e-01	5.76e-01	0.14500	0.137000	-0.047800	1.61e-01	0.625000
RUNX3 regulates NOTCH signaling	13	6.63e-01	8.18e-01	0.14500	-0.022900	0.143000	8.86e-01	0.371000
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	5.67e-01	7.56e-01	0.14500	0.015400	0.144000	9.10e-01	0.290000
DNA Repair	221	1.06e-03	1.64e-02	0.14500	0.137000	-0.047600	4.75e-04	0.225000
FCGR3A-mediated IL10 synthesis	40	2.87e-01	5.41e-01	0.14500	0.076800	0.122000	4.01e-01	0.181000
Transport of Mature Transcript to Cytoplasm	62	1.46e-01	3.63e-01	0.14400	0.127000	0.068000	8.31e-02	0.355000
G beta:gamma signalling through PLC beta	12	6.88e-01	8.41e-01	0.14400	-0.008090	-0.144000	9.61e-01	0.387000
TP53 Regulates Transcription of DNA Repair Genes	48	2.25e-01	4.74e-01	0.14400	0.123000	-0.074500	1.40e-01	0.372000
Signaling by high-kinase activity BRAF mutants	29	4.06e-01	6.51e-01	0.14400	0.140000	-0.035600	1.94e-01	0.740000
Cargo trafficking to the periciliary membrane	38	3.07e-01	5.57e-01	0.14400	-0.099200	0.104000	2.90e-01	0.266000
Synthesis of pyrophosphates in the cytosol	10	7.33e-01	8.71e-01	0.14400	-0.140000	-0.034900	4.45e-01	0.849000
Deadenylation-dependent mRNA decay	45	2.51e-01	5.03e-01	0.14300	0.094800	0.108000	2.72e-01	0.212000
Activation of NF-kappaB in B cells	55	1.85e-01	4.21e-01	0.14300	0.143000	0.002570	6.60e-02	0.974000
mTORC1-mediated signalling	20	5.40e-01	7.39e-01	0.14300	0.010300	0.143000	9.37e-01	0.268000
Regulation of IFNG signaling	12	6.92e-01	8.45e-01	0.14300	0.138000	-0.036700	4.07e-01	0.826000
C-type lectin receptors (CLRs)	101	4.68e-02	1.74e-01	0.14300	0.099200	0.103000	8.55e-02	0.074600
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	26	4.52e-01	6.88e-01	0.14300	-0.106000	0.095900	3.52e-01	0.398000
FOXO-mediated transcription	52	2.06e-01	4.53e-01	0.14300	-0.089400	0.111000	2.65e-01	0.166000
Iron uptake and transport	41	2.87e-01	5.41e-01	0.14300	-0.100000	0.101000	2.67e-01	0.262000
Resolution of D-loop Structures through Holliday Junction Intermediates	26	4.55e-01	6.89e-01	0.14200	0.088900	-0.111000	4.33e-01	0.328000
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	33	3.73e-01	6.18e-01	0.14100	-0.120000	-0.074700	2.33e-01	0.458000
rRNA modification in the nucleus and cytosol	46	2.52e-01	5.04e-01	0.14100	0.091200	-0.108000	2.85e-01	0.205000
IGF1R signaling cascade	38	3.21e-01	5.66e-01	0.14100	-0.108000	0.091400	2.51e-01	0.330000
Synthesis of IP3 and IP4 in the cytosol	20	5.53e-01	7.48e-01	0.14100	-0.033500	-0.137000	7.96e-01	0.290000
Endogenous sterols	17	6.11e-01	7.82e-01	0.13900	0.011900	0.139000	9.32e-01	0.323000
NS1 Mediated Effects on Host Pathways	28	4.45e-01	6.84e-01	0.13900	-0.033000	0.135000	7.62e-01	0.217000
GABA receptor activation	33	3.88e-01	6.34e-01	0.13800	-0.091700	0.104000	3.62e-01	0.303000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	25	4.89e-01	7.07e-01	0.13800	0.110000	-0.083400	3.41e-01	0.471000
Resolution of Sister Chromatid Cohesion	85	9.17e-02	2.72e-01	0.13800	0.104000	0.090100	9.82e-02	0.152000
ADP signalling through P2Y purinoceptor 1	17	6.18e-01	7.85e-01	0.13700	-0.047700	-0.129000	7.34e-01	0.357000
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	6.01e-01	7.75e-01	0.13700	-0.137000	-0.014600	3.16e-01	0.914000
HS-GAG biosynthesis	21	5.53e-01	7.48e-01	0.13700	-0.083000	0.109000	5.10e-01	0.386000
NCAM signaling for neurite out-growth	47	2.67e-01	5.22e-01	0.13700	-0.137000	-0.012800	1.06e-01	0.879000
Transport of Ribonucleoproteins into the Host Nucleus	23	5.23e-01	7.31e-01	0.13700	-0.078600	0.112000	5.14e-01	0.351000
Inactivation, recovery and regulation of the phototransduction cascade	17	6.21e-01	7.87e-01	0.13700	-0.121000	-0.063200	3.87e-01	0.652000
The phototransduction cascade	17	6.21e-01	7.87e-01	0.13700	-0.121000	-0.063200	3.87e-01	0.652000
Positive epigenetic regulation of rRNA expression	36	3.66e-01	6.12e-01	0.13700	0.023600	-0.135000	8.06e-01	0.163000
Regulation of PTEN stability and activity	53	2.29e-01	4.77e-01	0.13600	0.132000	-0.033300	9.63e-02	0.675000
Phase I - Functionalization of compounds	58	2.01e-01	4.47e-01	0.13600	0.075600	0.113000	3.20e-01	0.136000
Regulation of mRNA stability by proteins that bind AU-rich elements	72	1.37e-01	3.51e-01	0.13600	0.133000	-0.026500	5.06e-02	0.698000
DNA Double Strand Break Response	35	3.82e-01	6.29e-01	0.13600	0.018000	-0.134000	8.54e-01	0.169000
Deubiquitination	216	3.05e-03	3.28e-02	0.13500	0.121000	0.060800	2.35e-03	0.125000
Cell Cycle	500	2.08e-06	1.30e-04	0.13500	0.134000	0.017900	3.94e-07	0.497000
Processing of Capped Intron-Containing Pre-mRNA	180	7.94e-03	5.80e-02	0.13500	0.117000	0.067900	7.15e-03	0.117000
Diseases associated with O-glycosylation of proteins	43	3.11e-01	5.60e-01	0.13500	0.065000	-0.118000	4.61e-01	0.181000
TRAF6 mediated NF-kB activation	20	5.81e-01	7.59e-01	0.13500	0.042700	-0.128000	7.41e-01	0.323000
Signaling by Insulin receptor	55	2.27e-01	4.75e-01	0.13400	-0.100000	0.089700	2.00e-01	0.250000
Metabolism of non-coding RNA	39	3.49e-01	5.99e-01	0.13400	-0.008520	0.134000	9.27e-01	0.148000
snRNP Assembly	39	3.49e-01	5.99e-01	0.13400	-0.008520	0.134000	9.27e-01	0.148000
Effects of PIP2 hydrolysis	22	5.54e-01	7.48e-01	0.13400	-0.045300	-0.126000	7.13e-01	0.306000
Dopamine Neurotransmitter Release Cycle	14	6.87e-01	8.40e-01	0.13400	0.056500	0.122000	7.15e-01	0.431000
Cellular response to hypoxia	56	2.24e-01	4.72e-01	0.13400	0.130000	0.032800	9.32e-02	0.671000
mRNA Splicing	141	2.37e-02	1.17e-01	0.13400	0.123000	0.053900	1.22e-02	0.271000
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	39	3.53e-01	6.01e-01	0.13400	-0.103000	0.084800	2.65e-01	0.360000
Metabolism of RNA	494	3.18e-06	1.50e-04	0.13400	0.131000	0.025900	7.90e-07	0.329000
Neurotransmitter receptors and postsynaptic signal transmission	121	4.04e-02	1.56e-01	0.13400	-0.101000	0.087300	5.54e-02	0.098200
Response to elevated platelet cytosolic Ca2+	100	7.09e-02	2.31e-01	0.13300	0.131000	-0.024200	2.37e-02	0.676000
Signaling by NTRK3 (TRKC)	17	6.39e-01	7.98e-01	0.13300	-0.067300	0.114000	6.31e-01	0.415000
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	61	2.06e-01	4.53e-01	0.13200	0.131000	-0.013200	7.72e-02	0.859000
Oncogene Induced Senescence	27	4.97e-01	7.14e-01	0.13200	0.075600	0.108000	4.97e-01	0.333000
Cell Cycle, Mitotic	405	4.17e-05	1.22e-03	0.13100	0.130000	0.013500	7.89e-06	0.643000
Interleukin-2 family signaling	33	4.31e-01	6.74e-01	0.13100	0.031400	-0.127000	7.55e-01	0.208000
Chondroitin sulfate/dermatan sulfate metabolism	40	3.64e-01	6.11e-01	0.13000	0.108000	0.072400	2.37e-01	0.429000
PKMTs methylate histone lysines	35	4.14e-01	6.58e-01	0.13000	-0.085000	-0.098300	3.84e-01	0.315000
p75 NTR receptor-mediated signalling	75	1.53e-01	3.75e-01	0.13000	-0.057500	-0.116000	3.90e-01	0.082000
GAB1 signalosome	14	7.05e-01	8.53e-01	0.12900	-0.108000	0.070000	4.83e-01	0.651000
Ca2+ pathway	48	3.05e-01	5.56e-01	0.12900	-0.127000	0.018000	1.27e-01	0.829000
RNA Polymerase III Chain Elongation	13	7.26e-01	8.67e-01	0.12800	0.107000	-0.069800	5.03e-01	0.663000
Protein localization	122	5.19e-02	1.83e-01	0.12800	0.108000	-0.068800	4.06e-02	0.191000
COPI-mediated anterograde transport	70	1.83e-01	4.21e-01	0.12800	-0.125000	-0.023500	6.99e-02	0.734000
Interleukin-10 signaling	25	5.43e-01	7.41e-01	0.12800	0.106000	-0.071300	3.60e-01	0.537000
Transcriptional activation of mitochondrial biogenesis	49	3.05e-01	5.56e-01	0.12700	-0.120000	-0.044200	1.48e-01	0.593000
Regulation of RUNX2 expression and activity	57	2.52e-01	5.03e-01	0.12700	0.105000	0.072000	1.70e-01	0.348000
Activation of BH3-only proteins	27	5.21e-01	7.30e-01	0.12700	0.085000	0.094500	4.45e-01	0.396000
Export of Viral Ribonucleoproteins from Nucleus	24	5.66e-01	7.56e-01	0.12600	-0.074000	0.102000	5.30e-01	0.389000
Neuronal System	246	3.30e-03	3.46e-02	0.12600	-0.122000	0.031900	1.08e-03	0.392000
PCP/CE pathway	75	1.71e-01	4.06e-01	0.12600	0.055200	-0.113000	4.09e-01	0.091500
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	7.53e-01	8.85e-01	0.12600	-0.123000	-0.025500	4.61e-01	0.878000
Defective EXT2 causes exostoses 2	12	7.53e-01	8.85e-01	0.12600	-0.123000	-0.025500	4.61e-01	0.878000
Trafficking and processing of endosomal TLR	11	7.73e-01	8.91e-01	0.12500	0.124000	0.018400	4.77e-01	0.916000
Interleukin-6 signaling	10	7.92e-01	9.04e-01	0.12500	-0.037900	-0.119000	8.36e-01	0.515000
TNF signaling	33	4.64e-01	6.92e-01	0.12500	0.122000	0.026300	2.26e-01	0.794000
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	29	5.09e-01	7.19e-01	0.12500	-0.123000	0.019400	2.51e-01	0.857000
Semaphorin interactions	59	2.55e-01	5.05e-01	0.12500	0.125000	-0.001790	9.81e-02	0.981000
O-linked glycosylation of mucins	31	4.87e-01	7.07e-01	0.12500	0.022400	-0.123000	8.29e-01	0.238000
Chromatin modifying enzymes	169	2.18e-02	1.11e-01	0.12400	-0.094200	-0.080400	3.52e-02	0.072300
Chromatin organization	169	2.18e-02	1.11e-01	0.12400	-0.094200	-0.080400	3.52e-02	0.072300
Keratan sulfate biosynthesis	20	6.34e-01	7.95e-01	0.12300	-0.090400	-0.084100	4.84e-01	0.515000
Transmission across Chemical Synapses	160	2.78e-02	1.32e-01	0.12300	-0.116000	0.039400	1.13e-02	0.391000
Transcriptional Regulation by VENTX	33	4.77e-01	7.04e-01	0.12300	-0.102000	-0.067400	3.09e-01	0.503000
MAPK6/MAPK4 signaling	71	2.04e-01	4.53e-01	0.12200	0.105000	-0.063400	1.28e-01	0.356000
Metabolism of nitric oxide: NOS3 activation and regulation	14	7.31e-01	8.70e-01	0.12200	0.109000	-0.054200	4.79e-01	0.726000
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	7.66e-01	8.88e-01	0.12200	0.120000	0.020600	4.71e-01	0.902000
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	23	6.01e-01	7.75e-01	0.12200	0.109000	-0.053500	3.65e-01	0.657000
Platelet degranulation	96	1.22e-01	3.24e-01	0.12100	0.121000	0.002990	4.01e-02	0.960000
RNA Polymerase I Promoter Escape	21	6.33e-01	7.94e-01	0.12100	-0.108000	-0.053400	3.91e-01	0.672000
PRC2 methylates histones and DNA	12	7.70e-01	8.91e-01	0.12000	-0.033500	0.116000	8.41e-01	0.488000
Gap junction trafficking and regulation	16	7.09e-01	8.55e-01	0.12000	-0.120000	-0.005180	4.07e-01	0.971000
Fc epsilon receptor (FCERI) signaling	112	9.45e-02	2.78e-01	0.11900	0.090200	0.078000	1.00e-01	0.155000
FCERI mediated NF-kB activation	65	2.53e-01	5.04e-01	0.11900	0.112000	0.040800	1.19e-01	0.570000
Association of TriC/CCT with target proteins during biosynthesis	30	5.29e-01	7.35e-01	0.11900	-0.072500	0.094400	4.92e-01	0.371000
Gene Silencing by RNA	47	3.73e-01	6.18e-01	0.11900	-0.118000	-0.009680	1.61e-01	0.909000
cGMP effects	13	7.60e-01	8.87e-01	0.11900	0.117000	-0.016900	4.64e-01	0.916000
Amyloid fiber formation	32	5.10e-01	7.19e-01	0.11900	0.065900	-0.098500	5.19e-01	0.335000
Pre-NOTCH Expression and Processing	43	4.07e-01	6.51e-01	0.11800	-0.051400	-0.107000	5.60e-01	0.227000
Unblocking of NMDA receptors, glutamate binding and activation	15	7.30e-01	8.69e-01	0.11800	-0.085700	0.081600	5.66e-01	0.584000
Oncogenic MAPK signaling	67	2.48e-01	5.00e-01	0.11800	-0.116000	0.022400	1.01e-01	0.752000
Keratan sulfate/keratin metabolism	24	6.08e-01	7.81e-01	0.11800	-0.082400	-0.084300	4.85e-01	0.475000
Interactions of Vpr with host cellular proteins	26	5.85e-01	7.64e-01	0.11700	-0.062500	0.099200	5.82e-01	0.381000
Signaling by Retinoic Acid	31	5.30e-01	7.35e-01	0.11700	0.003910	-0.117000	9.70e-01	0.260000
Formation of HIV-1 elongation complex containing HIV-1 Tat	30	5.41e-01	7.39e-01	0.11700	-0.009740	-0.117000	9.26e-01	0.269000
HIV Transcription Elongation	30	5.41e-01	7.39e-01	0.11700	-0.009740	-0.117000	9.26e-01	0.269000
Tat-mediated elongation of the HIV-1 transcript	30	5.41e-01	7.39e-01	0.11700	-0.009740	-0.117000	9.26e-01	0.269000
Class A/1 (Rhodopsin-like receptors)	114	9.93e-02	2.85e-01	0.11700	0.094400	0.068900	8.22e-02	0.205000
Long-term potentiation	18	6.92e-01	8.45e-01	0.11700	-0.035400	0.111000	7.95e-01	0.414000
Regulation of PTEN gene transcription	54	3.36e-01	5.83e-01	0.11600	-0.088400	-0.075800	2.62e-01	0.336000
Glycogen breakdown (glycogenolysis)	14	7.54e-01	8.85e-01	0.11600	-0.113000	-0.025000	4.62e-01	0.871000
Plasma lipoprotein remodeling	14	7.54e-01	8.85e-01	0.11600	-0.004390	-0.116000	9.77e-01	0.453000
Glycosphingolipid metabolism	31	5.36e-01	7.38e-01	0.11600	-0.003960	-0.116000	9.70e-01	0.265000
Diseases of metabolism	164	3.89e-02	1.51e-01	0.11600	-0.073900	-0.089100	1.03e-01	0.049600
Potassium Channels	57	3.20e-01	5.66e-01	0.11600	-0.103000	0.053500	1.81e-01	0.485000
Regulation of signaling by CBL	18	6.98e-01	8.48e-01	0.11600	0.058300	0.099900	6.69e-01	0.463000
Asymmetric localization of PCP proteins	52	3.54e-01	6.01e-01	0.11600	0.061900	-0.097600	4.41e-01	0.224000
ADP signalling through P2Y purinoceptor 12	14	7.56e-01	8.85e-01	0.11600	0.059000	0.099300	7.02e-01	0.520000
Hyaluronan metabolism	13	7.71e-01	8.91e-01	0.11600	0.040900	-0.108000	7.98e-01	0.500000
Transcriptional regulation by RUNX2	98	1.46e-01	3.63e-01	0.11500	0.059300	0.098500	3.12e-01	0.092600
Translation of structural proteins	21	6.62e-01	8.17e-01	0.11500	-0.114000	0.003600	3.64e-01	0.977000
ERKs are inactivated	13	7.75e-01	8.93e-01	0.11400	0.070800	-0.089900	6.58e-01	0.575000
Nucleotide Excision Repair	86	1.89e-01	4.28e-01	0.11400	0.114000	-0.009970	6.89e-02	0.873000
Bile acid and bile salt metabolism	23	6.40e-01	7.98e-01	0.11400	-0.107000	-0.040200	3.76e-01	0.739000
Separation of Sister Chromatids	136	7.40e-02	2.35e-01	0.11400	0.113000	0.013400	2.34e-02	0.789000
Regulation of TP53 Degradation	29	5.74e-01	7.57e-01	0.11300	-0.055600	-0.098600	6.04e-01	0.359000
NR1H2 and NR1H3-mediated signaling	35	5.12e-01	7.21e-01	0.11300	-0.063100	-0.093900	5.18e-01	0.337000
EPH-Ephrin signaling	78	2.26e-01	4.75e-01	0.11300	0.113000	-0.010800	8.60e-02	0.869000
Global Genome Nucleotide Excision Repair (GG-NER)	68	2.75e-01	5.31e-01	0.11300	0.104000	-0.042800	1.38e-01	0.542000
Interaction between L1 and Ankyrins	23	6.46e-01	8.00e-01	0.11300	-0.111000	-0.018500	3.57e-01	0.878000
Defective B4GALT7 causes EDS, progeroid type	15	7.57e-01	8.85e-01	0.11100	0.075000	0.082300	6.15e-01	0.581000
Non-integrin membrane-ECM interactions	37	5.06e-01	7.19e-01	0.11100	-0.024000	-0.108000	8.01e-01	0.254000
N-glycan antennae elongation in the medial/trans-Golgi	19	7.05e-01	8.53e-01	0.11100	-0.037000	-0.105000	7.80e-01	0.430000
Sphingolipid de novo biosynthesis	31	5.66e-01	7.56e-01	0.11100	-0.091600	0.062000	3.78e-01	0.551000
RNA polymerase II transcribes snRNA genes	59	3.42e-01	5.90e-01	0.11000	-0.052500	0.096900	4.86e-01	0.198000
Vpr-mediated nuclear import of PICs	24	6.46e-01	8.00e-01	0.11000	-0.075000	0.080600	5.25e-01	0.494000
mRNA decay by 5' to 3' exoribonuclease	13	7.91e-01	9.04e-01	0.11000	-0.063700	-0.089300	6.91e-01	0.577000
Defective B3GAT3 causes JDSSDHD	15	7.65e-01	8.88e-01	0.10900	0.058500	0.092200	6.95e-01	0.536000
Platelet homeostasis	65	3.18e-01	5.66e-01	0.10900	-0.013400	-0.108000	8.52e-01	0.133000
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	44	4.60e-01	6.92e-01	0.10900	0.069100	0.084000	4.28e-01	0.336000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	13	7.96e-01	9.05e-01	0.10800	0.010600	-0.108000	9.47e-01	0.501000
Activation of GABAB receptors	30	5.91e-01	7.68e-01	0.10800	-0.074600	0.078200	4.80e-01	0.459000
GABA B receptor activation	30	5.91e-01	7.68e-01	0.10800	-0.074600	0.078200	4.80e-01	0.459000
G beta:gamma signalling through CDC42	12	8.12e-01	9.18e-01	0.10800	0.069300	0.082400	6.78e-01	0.621000
Metabolism of nucleotides	78	2.73e-01	5.29e-01	0.10600	0.085000	-0.062600	1.95e-01	0.340000
Ovarian tumor domain proteases	28	6.28e-01	7.92e-01	0.10500	0.048100	0.093800	6.60e-01	0.391000
Adaptive Immune System	546	1.75e-04	4.00e-03	0.10500	0.095200	0.045000	1.69e-04	0.075000
N-Glycan antennae elongation	12	8.19e-01	9.24e-01	0.10500	0.007390	-0.105000	9.65e-01	0.529000
Membrane Trafficking	491	4.63e-04	9.13e-03	0.10400	-0.102000	0.020800	1.24e-04	0.435000
p75NTR signals via NF-kB	10	8.51e-01	9.39e-01	0.10400	-0.102000	-0.017100	5.75e-01	0.925000
Visual phototransduction	50	4.47e-01	6.84e-01	0.10400	-0.072100	-0.074800	3.78e-01	0.361000
NOTCH4 Intracellular Domain Regulates Transcription	17	7.60e-01	8.87e-01	0.10400	-0.003670	0.104000	9.79e-01	0.459000
RHO GTPases Activate Formins	96	2.15e-01	4.65e-01	0.10400	0.045200	0.093400	4.45e-01	0.115000
Nuclear Pore Complex (NPC) Disassembly	27	6.48e-01	8.01e-01	0.10400	-0.005810	0.103000	9.58e-01	0.353000
Diseases of glycosylation	107	1.82e-01	4.21e-01	0.10300	-0.019500	-0.102000	7.28e-01	0.069900
MET promotes cell motility	28	6.40e-01	7.98e-01	0.10300	-0.033700	0.097600	7.58e-01	0.372000
Platelet calcium homeostasis	20	7.27e-01	8.67e-01	0.10300	-0.088100	-0.053800	4.96e-01	0.677000
Cell-Cell communication	77	2.95e-01	5.47e-01	0.10300	0.025500	0.100000	6.99e-01	0.130000
SUMOylation of transcription cofactors	36	5.65e-01	7.56e-01	0.10300	-0.091200	-0.048000	3.44e-01	0.619000
Formation of the Early Elongation Complex	25	6.73e-01	8.28e-01	0.10300	-0.070400	-0.075200	5.43e-01	0.516000
Formation of the HIV-1 Early Elongation Complex	25	6.73e-01	8.28e-01	0.10300	-0.070400	-0.075200	5.43e-01	0.516000
Regulation of TP53 Activity	135	1.24e-01	3.29e-01	0.10200	-0.034400	-0.096300	4.92e-01	0.054000
Inositol phosphate metabolism	41	5.35e-01	7.38e-01	0.10100	-0.082200	-0.058900	3.63e-01	0.515000
Amine ligand-binding receptors	11	8.45e-01	9.39e-01	0.10100	-0.085900	0.053400	6.22e-01	0.759000
RHO GTPases activate PKNs	31	6.23e-01	7.88e-01	0.10100	0.085400	0.054100	4.11e-01	0.603000
RHO GTPase Effectors	205	4.57e-02	1.72e-01	0.10100	0.101000	-0.002660	1.30e-02	0.948000
Regulation of TP53 Expression and Degradation	30	6.35e-01	7.95e-01	0.10100	-0.069900	-0.072400	5.08e-01	0.493000
Metabolism of carbohydrates	215	4.09e-02	1.57e-01	0.10100	-0.065400	-0.076400	9.99e-02	0.054400
Signaling by KIT in disease	20	7.39e-01	8.74e-01	0.10100	0.060100	0.080600	6.42e-01	0.533000
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	7.39e-01	8.74e-01	0.10100	0.060100	0.080600	6.42e-01	0.533000
Degradation of beta-catenin by the destruction complex	69	3.57e-01	6.03e-01	0.10000	0.098300	-0.018700	1.59e-01	0.788000
Metabolic disorders of biological oxidation enzymes	18	7.63e-01	8.88e-01	0.10000	-0.043600	0.090000	7.49e-01	0.509000
Immune System	1422	7.88e-09	1.65e-06	0.09970	0.099600	-0.003410	1.03e-09	0.835000
HIV Transcription Initiation	37	5.78e-01	7.57e-01	0.09950	-0.083600	0.054000	3.80e-01	0.570000
RNA Polymerase II HIV Promoter Escape	37	5.78e-01	7.57e-01	0.09950	-0.083600	0.054000	3.80e-01	0.570000
RNA Polymerase II Promoter Escape	37	5.78e-01	7.57e-01	0.09950	-0.083600	0.054000	3.80e-01	0.570000
RNA Polymerase II Transcription Initiation	37	5.78e-01	7.57e-01	0.09950	-0.083600	0.054000	3.80e-01	0.570000
RNA Polymerase II Transcription Initiation And Promoter Clearance	37	5.78e-01	7.57e-01	0.09950	-0.083600	0.054000	3.80e-01	0.570000
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	37	5.78e-01	7.57e-01	0.09950	-0.083600	0.054000	3.80e-01	0.570000
Signaling by PDGFR in disease	19	7.55e-01	8.85e-01	0.09940	-0.090600	0.041000	4.94e-01	0.757000
Mitochondrial protein import	49	4.86e-01	7.07e-01	0.09930	0.051400	-0.084900	5.34e-01	0.304000
Collagen degradation	25	6.93e-01	8.45e-01	0.09900	-0.095000	-0.027700	4.11e-01	0.811000
ESR-mediated signaling	133	1.44e-01	3.62e-01	0.09900	-0.044800	0.088300	3.73e-01	0.079600
Signaling by ERBB4	40	5.59e-01	7.54e-01	0.09850	-0.072300	0.066900	4.29e-01	0.464000
ABC-family proteins mediated transport	73	3.49e-01	5.99e-01	0.09830	0.049900	-0.084700	4.62e-01	0.211000
Platelet activation, signaling and aggregation	197	6.06e-02	2.06e-01	0.09820	0.095700	-0.022100	2.11e-02	0.595000
ZBP1(DAI) mediated induction of type I IFNs	18	7.72e-01	8.91e-01	0.09810	0.001230	-0.098100	9.93e-01	0.471000
G2/M Transition	151	1.17e-01	3.15e-01	0.09800	0.097900	0.005030	3.84e-02	0.915000
Intrinsic Pathway for Apoptosis	42	5.49e-01	7.45e-01	0.09770	0.097600	0.003990	2.74e-01	0.964000
Leishmania infection	157	1.10e-01	3.01e-01	0.09750	0.093700	-0.026900	4.34e-02	0.563000
TCF dependent signaling in response to WNT	133	1.56e-01	3.79e-01	0.09710	-0.097100	0.002830	5.38e-02	0.955000
A tetrasaccharide linker sequence is required for GAG synthesis	19	7.67e-01	8.89e-01	0.09670	0.068800	0.067900	6.04e-01	0.608000
Mitotic G2-G2/M phases	153	1.21e-01	3.24e-01	0.09660	0.096200	0.007830	4.05e-02	0.868000
Chaperone Mediated Autophagy	13	8.35e-01	9.31e-01	0.09650	-0.074600	-0.061200	6.41e-01	0.703000
NOTCH3 Intracellular Domain Regulates Transcription	21	7.47e-01	8.82e-01	0.09620	-0.025200	0.092900	8.42e-01	0.461000
Class B/2 (Secretin family receptors)	38	5.94e-01	7.70e-01	0.09570	-0.093500	0.020400	3.19e-01	0.828000
Elastic fibre formation	35	6.20e-01	7.87e-01	0.09570	-0.061300	-0.073400	5.30e-01	0.453000
EML4 and NUDC in mitotic spindle formation	77	3.51e-01	6.00e-01	0.09560	0.023500	0.092600	7.21e-01	0.160000
Rab regulation of trafficking	104	2.45e-01	4.96e-01	0.09550	-0.090100	-0.031500	1.13e-01	0.579000
Negative regulation of the PI3K/AKT network	87	3.08e-01	5.57e-01	0.09540	-0.006560	0.095200	9.16e-01	0.126000
Signaling by PDGFRA extracellular domain mutants	12	8.51e-01	9.39e-01	0.09470	0.017200	0.093100	9.18e-01	0.577000
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.51e-01	9.39e-01	0.09470	0.017200	0.093100	9.18e-01	0.577000
Regulation of lipid metabolism by PPARalpha	102	2.57e-01	5.08e-01	0.09470	-0.002390	0.094600	9.67e-01	0.099300
Vesicle-mediated transport	521	1.24e-03	1.81e-02	0.09460	-0.094100	0.009770	2.74e-04	0.706000
Activation of HOX genes during differentiation	42	5.70e-01	7.57e-01	0.09450	-0.060100	0.072900	5.01e-01	0.414000
Activation of anterior HOX genes in hindbrain development during early embryogenesis	42	5.70e-01	7.57e-01	0.09450	-0.060100	0.072900	5.01e-01	0.414000
Signaling by MET	58	4.63e-01	6.92e-01	0.09420	-0.069300	0.063800	3.62e-01	0.401000
Senescence-Associated Secretory Phenotype (SASP)	39	6.02e-01	7.75e-01	0.09320	0.027600	-0.089000	7.66e-01	0.337000
Assembly of collagen fibrils and other multimeric structures	44	5.66e-01	7.56e-01	0.09310	-0.004990	-0.093000	9.54e-01	0.286000
PPARA activates gene expression	100	2.77e-01	5.33e-01	0.09290	-0.011900	0.092200	8.37e-01	0.112000
Gap junction trafficking	14	8.36e-01	9.31e-01	0.09260	-0.092400	0.005370	5.50e-01	0.972000
Formation of HIV elongation complex in the absence of HIV Tat	31	6.74e-01	8.28e-01	0.09230	0.019100	-0.090300	8.54e-01	0.385000
Negative epigenetic regulation of rRNA expression	36	6.33e-01	7.94e-01	0.09220	0.090900	0.015500	3.46e-01	0.872000
SLC-mediated transmembrane transport	148	1.55e-01	3.78e-01	0.09220	0.010200	-0.091600	8.31e-01	0.055100
ERK/MAPK targets	22	7.56e-01	8.85e-01	0.09220	-0.071800	0.057800	5.60e-01	0.639000
TP53 Regulates Metabolic Genes	71	4.08e-01	6.51e-01	0.09200	-0.077200	0.050000	2.61e-01	0.467000
SUMOylation of chromatin organization proteins	44	5.73e-01	7.57e-01	0.09190	-0.084900	0.035200	3.30e-01	0.686000
NEP/NS2 Interacts with the Cellular Export Machinery	23	7.51e-01	8.85e-01	0.09120	-0.035600	0.083900	7.68e-01	0.486000
SLC transporter disorders	59	4.83e-01	7.07e-01	0.09100	-0.075300	-0.051100	3.18e-01	0.497000
RNA Polymerase III Transcription Initiation From Type 1 Promoter	20	7.82e-01	8.97e-01	0.09060	0.075800	-0.049800	5.58e-01	0.700000
VEGFR2 mediated vascular permeability	27	7.18e-01	8.61e-01	0.09060	-0.068000	0.059800	5.41e-01	0.591000
Post-translational modification: synthesis of GPI-anchored proteins	54	5.26e-01	7.33e-01	0.08920	-0.069900	0.055500	3.75e-01	0.481000
Hedgehog 'on' state	68	4.46e-01	6.84e-01	0.08920	0.078500	-0.042300	2.63e-01	0.547000
HCMV Late Events	41	6.16e-01	7.85e-01	0.08910	-0.084300	-0.028600	3.51e-01	0.751000
Signaling by Erythropoietin	23	7.62e-01	8.87e-01	0.08900	0.031600	0.083200	7.93e-01	0.490000
Inwardly rectifying K+ channels	21	7.80e-01	8.97e-01	0.08890	-0.035300	-0.081600	7.79e-01	0.518000
O-linked glycosylation	67	4.54e-01	6.89e-01	0.08890	-0.009280	-0.088400	8.96e-01	0.212000
Interleukin-7 signaling	16	8.28e-01	9.29e-01	0.08870	0.041000	-0.078700	7.77e-01	0.586000
Downstream signal transduction	28	7.21e-01	8.64e-01	0.08840	-0.039200	0.079200	7.20e-01	0.469000
trans-Golgi Network Vesicle Budding	59	5.03e-01	7.19e-01	0.08830	-0.088200	0.004160	2.42e-01	0.956000
HCMV Infection	64	4.78e-01	7.04e-01	0.08800	-0.087800	0.004760	2.25e-01	0.948000
Caspase-mediated cleavage of cytoskeletal proteins	11	8.81e-01	9.53e-01	0.08760	-0.070300	-0.052300	6.87e-01	0.764000
Plasma lipoprotein assembly, remodeling, and clearance	45	5.97e-01	7.72e-01	0.08750	0.040800	-0.077400	6.36e-01	0.370000
Protein-protein interactions at synapses	60	5.05e-01	7.19e-01	0.08740	-0.084800	-0.021100	2.57e-01	0.778000
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	73	4.37e-01	6.77e-01	0.08730	0.048400	0.072700	4.75e-01	0.284000
Amplification of signal from the kinetochores	73	4.37e-01	6.77e-01	0.08730	0.048400	0.072700	4.75e-01	0.284000
COPI-dependent Golgi-to-ER retrograde traffic	67	4.68e-01	6.94e-01	0.08720	0.002920	-0.087200	9.67e-01	0.218000
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	8.53e-01	9.39e-01	0.08710	-0.076500	-0.041600	6.20e-01	0.788000
Nonhomologous End-Joining (NHEJ)	28	7.30e-01	8.69e-01	0.08670	0.084800	-0.017800	4.38e-01	0.871000
Gamma carboxylation, hypusine formation and arylsulfatase activation	26	7.48e-01	8.83e-01	0.08640	-0.033000	-0.079800	7.71e-01	0.481000
Mitochondrial translation	70	4.64e-01	6.92e-01	0.08590	-0.069500	-0.050500	3.15e-01	0.466000
The citric acid (TCA) cycle and respiratory electron transport	114	2.89e-01	5.41e-01	0.08570	0.046300	0.072100	3.94e-01	0.185000
Degradation of the extracellular matrix	71	4.64e-01	6.92e-01	0.08520	-0.042200	-0.074000	5.39e-01	0.281000
Chaperonin-mediated protein folding	68	4.80e-01	7.04e-01	0.08500	-0.068200	0.050700	3.32e-01	0.470000
Constitutive Signaling by Aberrant PI3K in Cancer	56	5.48e-01	7.44e-01	0.08500	0.041500	0.074100	5.91e-01	0.338000
RNA Polymerase I Transcription Termination	21	7.97e-01	9.06e-01	0.08490	-0.058000	-0.062100	6.46e-01	0.623000
ISG15 antiviral mechanism	51	5.78e-01	7.57e-01	0.08490	0.071000	0.046600	3.81e-01	0.566000
tRNA processing	84	4.06e-01	6.51e-01	0.08480	0.060500	-0.059300	3.38e-01	0.348000
Toll Like Receptor 4 (TLR4) Cascade	107	3.21e-01	5.66e-01	0.08440	-0.062000	0.057400	2.69e-01	0.306000
Diseases associated with the TLR signaling cascade	20	8.08e-01	9.16e-01	0.08430	-0.084100	-0.005270	5.15e-01	0.967000
Diseases of Immune System	20	8.08e-01	9.16e-01	0.08430	-0.084100	-0.005270	5.15e-01	0.967000
HCMV Early Events	46	6.16e-01	7.85e-01	0.08390	-0.067600	0.049800	4.28e-01	0.560000
Programmed Cell Death	140	2.38e-01	4.88e-01	0.08320	0.070100	0.044800	1.53e-01	0.361000
MHC class II antigen presentation	88	4.03e-01	6.48e-01	0.08320	0.047800	-0.068100	4.39e-01	0.270000
Signaling by PDGF	47	6.16e-01	7.85e-01	0.08300	-0.081200	0.017200	3.36e-01	0.838000
Hemostasis	427	1.43e-02	8.18e-02	0.08300	0.082900	-0.002520	3.57e-03	0.929000
Antigen processing: Ubiquitination & Proteasome degradation	244	8.49e-02	2.59e-01	0.08290	-0.018400	0.080900	6.22e-01	0.030400
DDX58/IFIH1-mediated induction of interferon-alpha/beta	48	6.10e-01	7.82e-01	0.08290	0.063100	-0.053800	4.50e-01	0.519000
G-protein beta:gamma signalling	23	7.90e-01	9.04e-01	0.08280	0.067100	-0.048500	5.78e-01	0.688000
Mitotic Prometaphase	154	2.11e-01	4.58e-01	0.08260	0.068100	0.046800	1.46e-01	0.318000
RNA Polymerase III Abortive And Retractive Initiation	33	7.15e-01	8.60e-01	0.08240	0.081900	0.009780	4.16e-01	0.923000
RNA Polymerase III Transcription	33	7.15e-01	8.60e-01	0.08240	0.081900	0.009780	4.16e-01	0.923000
Signal transduction by L1	19	8.25e-01	9.26e-01	0.08240	0.071200	0.041400	5.91e-01	0.755000
Transcriptional regulation of white adipocyte differentiation	69	4.99e-01	7.14e-01	0.08220	-0.019400	0.079900	7.80e-01	0.252000
Signaling by WNT	204	1.33e-01	3.46e-01	0.08190	-0.081600	0.006480	4.53e-02	0.874000
Regulation of PLK1 Activity at G2/M Transition	72	4.88e-01	7.07e-01	0.08170	-0.033300	0.074600	6.26e-01	0.275000
Apoptosis	137	2.64e-01	5.16e-01	0.08110	0.065800	0.047400	1.85e-01	0.339000
Nuclear signaling by ERBB4	25	7.83e-01	8.98e-01	0.08090	-0.080500	-0.008550	4.86e-01	0.941000
G alpha (s) signalling events	78	4.67e-01	6.94e-01	0.08090	-0.051800	0.062100	4.30e-01	0.344000
Estrogen-dependent gene expression	76	4.77e-01	7.04e-01	0.08080	-0.075300	0.029200	2.57e-01	0.660000
Organelle biogenesis and maintenance	220	1.21e-01	3.24e-01	0.08080	-0.080700	0.002190	3.99e-02	0.956000
Neurexins and neuroligins	37	7.01e-01	8.50e-01	0.08020	-0.035000	-0.072200	7.13e-01	0.448000
Regulation of localization of FOXO transcription factors	12	8.91e-01	9.56e-01	0.08020	-0.057500	0.055900	7.30e-01	0.738000
Intra-Golgi and retrograde Golgi-to-ER traffic	153	2.36e-01	4.86e-01	0.07980	-0.042800	0.067400	3.63e-01	0.152000
Insulin receptor recycling	17	8.50e-01	9.39e-01	0.07970	-0.033000	0.072600	8.14e-01	0.604000
Disorders of transmembrane transporters	111	3.54e-01	6.01e-01	0.07930	0.049400	-0.062000	3.69e-01	0.260000
Regulation of TP53 Activity through Phosphorylation	76	4.92e-01	7.10e-01	0.07910	0.003990	-0.079000	9.52e-01	0.234000
Phospholipid metabolism	162	2.29e-01	4.77e-01	0.07850	-0.047200	-0.062800	3.01e-01	0.169000
Laminin interactions	22	8.19e-01	9.24e-01	0.07790	-0.016900	-0.076000	8.91e-01	0.537000
Nuclear Receptor transcription pathway	43	6.78e-01	8.32e-01	0.07780	-0.077600	0.004590	3.79e-01	0.958000
Interleukin-35 Signalling	10	9.13e-01	9.66e-01	0.07780	0.047800	-0.061400	7.94e-01	0.737000
Post-translational protein phosphorylation	67	5.47e-01	7.43e-01	0.07770	-0.069600	0.034400	3.25e-01	0.627000
Translation	178	2.05e-01	4.53e-01	0.07770	0.074800	-0.020900	8.63e-02	0.632000
Infectious disease	501	1.34e-02	7.84e-02	0.07750	0.076600	0.011600	3.67e-03	0.659000
ADORA2B mediated anti-inflammatory cytokines production	55	6.10e-01	7.82e-01	0.07750	-0.052000	0.057400	5.06e-01	0.462000
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	15	8.75e-01	9.50e-01	0.07710	-0.031800	0.070200	8.31e-01	0.638000
Phosphorylation of the APC/C	17	8.63e-01	9.43e-01	0.07630	-0.031600	-0.069400	8.22e-01	0.620000
Clathrin-mediated endocytosis	110	3.88e-01	6.34e-01	0.07610	-0.070300	0.029100	2.04e-01	0.599000
Amino acids regulate mTORC1	42	6.97e-01	8.48e-01	0.07580	-0.055400	0.051800	5.35e-01	0.562000
Golgi Cisternae Pericentriolar Stack Reorganization	12	9.02e-01	9.59e-01	0.07570	0.017500	-0.073600	9.16e-01	0.659000
APC/C:Cdc20 mediated degradation of Cyclin B	18	8.57e-01	9.39e-01	0.07560	0.014600	-0.074200	9.15e-01	0.586000
SUMOylation of RNA binding proteins	36	7.35e-01	8.72e-01	0.07550	-0.073000	0.019500	4.49e-01	0.840000
Cytokine Signaling in Immune system	605	7.55e-03	5.65e-02	0.07540	0.074600	0.010600	1.96e-03	0.659000
Cell junction organization	46	6.83e-01	8.36e-01	0.07460	-0.068600	-0.029300	4.21e-01	0.731000
RNA Polymerase II Pre-transcription Events	62	6.00e-01	7.75e-01	0.07420	-0.068300	0.029200	3.53e-01	0.692000
Class I MHC mediated antigen processing & presentation	291	9.63e-02	2.81e-01	0.07420	0.019900	0.071500	5.62e-01	0.037000
Presynaptic function of Kainate receptors	13	8.99e-01	9.58e-01	0.07390	0.010800	-0.073100	9.46e-01	0.648000
Muscle contraction	154	2.89e-01	5.41e-01	0.07380	-0.072800	0.012100	1.20e-01	0.797000
CLEC7A (Dectin-1) signaling	80	5.29e-01	7.35e-01	0.07310	0.059800	0.042100	3.56e-01	0.516000
Golgi-to-ER retrograde transport	97	4.63e-01	6.92e-01	0.07310	-0.064100	-0.035200	2.76e-01	0.550000
Signaling by VEGF	95	4.71e-01	6.97e-01	0.07300	0.071700	-0.013600	2.28e-01	0.820000
Mitotic Metaphase and Anaphase	185	2.38e-01	4.88e-01	0.07250	0.072500	0.001970	9.03e-02	0.963000
Cellular Senescence	108	4.36e-01	6.77e-01	0.07200	-0.066100	-0.028500	2.36e-01	0.609000
Scavenging by Class A Receptors	13	9.05e-01	9.60e-01	0.07180	0.039900	0.059700	8.03e-01	0.709000
Signaling by Rho GTPases	319	9.32e-02	2.75e-01	0.07130	0.066300	-0.026400	4.31e-02	0.421000
Interactions of Rev with host cellular proteins	26	8.21e-01	9.24e-01	0.07130	0.003180	0.071200	9.78e-01	0.530000
Transport of small molecules	456	3.58e-02	1.47e-01	0.07120	-0.059600	-0.039000	3.07e-02	0.157000
Metabolism of water-soluble vitamins and cofactors	89	5.14e-01	7.21e-01	0.07100	-0.044500	-0.055300	4.69e-01	0.368000
Beta-catenin independent WNT signaling	116	4.19e-01	6.65e-01	0.07100	0.020100	-0.068100	7.10e-01	0.206000
mRNA Capping	21	8.58e-01	9.39e-01	0.06980	-0.067500	0.018000	5.93e-01	0.887000
Late Phase of HIV Life Cycle	99	4.89e-01	7.07e-01	0.06970	-0.068100	0.014600	2.42e-01	0.802000
Metabolism of steroid hormones	18	8.78e-01	9.52e-01	0.06960	0.045400	0.052800	7.39e-01	0.698000
Signaling by NOTCH1	61	6.44e-01	8.00e-01	0.06960	-0.065100	0.024600	3.80e-01	0.740000
G alpha (q) signalling events	118	4.33e-01	6.75e-01	0.06920	0.021100	0.065900	6.93e-01	0.217000
Signaling by Interleukins	325	1.04e-01	2.91e-01	0.06920	0.068200	0.011900	3.59e-02	0.715000
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	22	8.54e-01	9.39e-01	0.06910	-0.059600	0.035000	6.29e-01	0.776000
Regulation of Glucokinase by Glucokinase Regulatory Protein	22	8.54e-01	9.39e-01	0.06910	-0.059600	0.035000	6.29e-01	0.776000
VEGFA-VEGFR2 Pathway	89	5.38e-01	7.39e-01	0.06840	0.066600	-0.015300	2.78e-01	0.803000
Transcriptional regulation by small RNAs	33	7.97e-01	9.05e-01	0.06790	-0.067400	0.008110	5.03e-01	0.936000
Mitotic Anaphase	184	2.89e-01	5.41e-01	0.06760	0.067600	-0.000155	1.15e-01	0.997000
Ephrin signaling	19	8.80e-01	9.53e-01	0.06700	0.043500	0.051000	7.43e-01	0.700000
VEGFR2 mediated cell proliferation	19	8.81e-01	9.53e-01	0.06690	0.057800	0.033700	6.63e-01	0.800000
CD28 dependent PI3K/Akt signaling	21	8.72e-01	9.50e-01	0.06600	0.050900	0.042000	6.87e-01	0.739000
Toll-like Receptor Cascades	122	4.56e-01	6.89e-01	0.06580	-0.041500	0.051100	4.29e-01	0.331000
Growth hormone receptor signaling	17	8.99e-01	9.58e-01	0.06480	-0.064100	0.009290	6.47e-01	0.947000
GPCR ligand binding	155	3.84e-01	6.31e-01	0.06470	0.042800	0.048500	3.59e-01	0.299000
Formation of TC-NER Pre-Incision Complex	38	7.89e-01	9.04e-01	0.06460	0.028000	0.058200	7.65e-01	0.535000
M Phase	285	1.76e-01	4.14e-01	0.06450	0.063800	0.009880	6.54e-02	0.775000
Metabolism of vitamins and cofactors	134	4.38e-01	6.78e-01	0.06450	-0.041500	-0.049300	4.08e-01	0.325000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	73	6.37e-01	7.96e-01	0.06430	-0.058600	0.026500	3.87e-01	0.696000
Signaling by Receptor Tyrosine Kinases	396	9.71e-02	2.83e-01	0.06370	-0.056000	0.030300	5.78e-02	0.304000
Nuclear Envelope (NE) Reassembly	58	7.13e-01	8.60e-01	0.06250	-0.057200	-0.025200	4.52e-01	0.740000
Metabolism of fat-soluble vitamins	27	8.54e-01	9.39e-01	0.06250	-0.011000	-0.061500	9.21e-01	0.580000
Defective B3GALTL causes Peters-plus syndrome (PpS)	31	8.35e-01	9.31e-01	0.06220	0.019600	-0.059100	8.51e-01	0.569000
O-glycosylation of TSR domain-containing proteins	32	8.32e-01	9.31e-01	0.06200	0.013000	-0.060600	8.99e-01	0.553000
p38MAPK events	12	9.33e-01	9.82e-01	0.06200	0.039700	-0.047500	8.12e-01	0.776000
Axon guidance	394	1.12e-01	3.06e-01	0.06190	0.049100	0.037800	9.72e-02	0.202000
Interleukin-37 signaling	18	9.02e-01	9.59e-01	0.06190	0.032000	-0.052900	8.14e-01	0.698000
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	81	6.31e-01	7.93e-01	0.06180	-0.015800	0.059700	8.06e-01	0.354000
Signaling by Hedgehog	111	5.33e-01	7.37e-01	0.06180	-0.061100	-0.009020	2.67e-01	0.870000
Rev-mediated nuclear export of HIV RNA	25	8.67e-01	9.47e-01	0.06170	0.005150	0.061500	9.64e-01	0.595000
Neurotransmitter release cycle	29	8.48e-01	9.39e-01	0.06160	-0.057800	0.021400	5.90e-01	0.842000
Diseases of signal transduction by growth factor receptors and second messengers	307	1.90e-01	4.31e-01	0.06080	-0.059500	0.012600	7.49e-02	0.706000
RIP-mediated NFkB activation via ZBP1	15	9.21e-01	9.72e-01	0.06060	-0.024600	-0.055400	8.69e-01	0.711000
Extracellular matrix organization	212	3.20e-01	5.66e-01	0.06040	-0.012600	-0.059100	7.54e-01	0.140000
Retinoid metabolism and transport	25	8.73e-01	9.50e-01	0.06020	0.029300	-0.052600	8.00e-01	0.649000
Transcriptional regulation by RUNX1	146	4.57e-01	6.91e-01	0.06010	0.041300	-0.043600	3.90e-01	0.364000
SUMO E3 ligases SUMOylate target proteins	131	4.98e-01	7.14e-01	0.05990	0.059800	0.003840	2.39e-01	0.940000
Signaling by NOTCH3	38	8.16e-01	9.22e-01	0.05990	0.055800	0.021700	5.52e-01	0.817000
Fatty acyl-CoA biosynthesis	22	8.90e-01	9.56e-01	0.05940	0.019800	-0.056000	8.72e-01	0.649000
Mitochondrial translation elongation	64	7.15e-01	8.60e-01	0.05930	-0.030200	-0.051100	6.77e-01	0.480000
Intraflagellar transport	35	8.32e-01	9.31e-01	0.05920	-0.030300	0.050900	7.57e-01	0.603000
Intracellular signaling by second messengers	254	2.72e-01	5.28e-01	0.05910	-0.053300	0.025500	1.46e-01	0.486000
Interleukin-3, Interleukin-5 and GM-CSF signaling	37	8.28e-01	9.29e-01	0.05850	-0.024100	-0.053300	8.00e-01	0.575000
Signaling by BRAF and RAF fusions	53	7.65e-01	8.88e-01	0.05810	-0.058100	0.002860	4.65e-01	0.971000
Cilium Assembly	153	4.66e-01	6.93e-01	0.05800	-0.050500	0.028500	2.82e-01	0.544000
Anti-inflammatory response favouring Leishmania parasite infection	88	6.47e-01	8.00e-01	0.05770	0.055200	0.017100	3.72e-01	0.782000
Leishmania parasite growth and survival	88	6.47e-01	8.00e-01	0.05770	0.055200	0.017100	3.72e-01	0.782000
Signaling by NOTCH	146	4.86e-01	7.07e-01	0.05770	0.044400	-0.036900	3.56e-01	0.443000
Recycling pathway of L1	27	8.74e-01	9.50e-01	0.05760	-0.024300	0.052200	8.27e-01	0.639000
tRNA processing in the nucleus	47	7.95e-01	9.05e-01	0.05730	0.035700	0.044800	6.73e-01	0.595000
SUMOylation	137	5.17e-01	7.25e-01	0.05700	0.056500	-0.007850	2.55e-01	0.874000
RAB geranylgeranylation	46	8.02e-01	9.10e-01	0.05670	0.037300	0.042700	6.62e-01	0.617000
Transport of the SLBP independent Mature mRNA	24	8.91e-01	9.56e-01	0.05670	-0.027000	0.049800	8.19e-01	0.673000
Mitochondrial translation termination	64	7.37e-01	8.73e-01	0.05660	-0.043200	-0.036500	5.50e-01	0.614000
Protein folding	74	7.02e-01	8.50e-01	0.05660	-0.053500	0.018600	4.27e-01	0.783000
HIV Infection	176	4.35e-01	6.77e-01	0.05660	0.056500	0.002020	1.97e-01	0.963000
Mitotic Spindle Checkpoint	88	6.62e-01	8.17e-01	0.05610	0.016500	0.053600	7.89e-01	0.385000
Transport of the SLBP Dependant Mature mRNA	25	8.90e-01	9.56e-01	0.05570	0.001050	0.055700	9.93e-01	0.630000
Sphingolipid metabolism	62	7.56e-01	8.85e-01	0.05500	-0.047900	-0.027000	5.15e-01	0.713000
EPH-ephrin mediated repulsion of cells	40	8.35e-01	9.31e-01	0.05490	0.018600	-0.051700	8.39e-01	0.572000
Molecules associated with elastic fibres	27	8.86e-01	9.55e-01	0.05480	-0.022800	-0.049900	8.38e-01	0.654000
Rho GTPase cycle	123	5.87e-01	7.65e-01	0.05400	0.016800	-0.051400	7.49e-01	0.326000
G-protein activation	15	9.37e-01	9.83e-01	0.05390	-0.053900	0.002670	7.18e-01	0.986000
HIV Life Cycle	108	6.29e-01	7.92e-01	0.05380	-0.050700	0.017900	3.64e-01	0.749000
NoRC negatively regulates rRNA expression	33	8.69e-01	9.48e-01	0.05330	0.053300	0.001060	5.96e-01	0.992000
Heparan sulfate/heparin (HS-GAG) metabolism	37	8.55e-01	9.39e-01	0.05310	-0.005110	0.052900	9.57e-01	0.578000
Metabolism of cofactors	19	9.24e-01	9.75e-01	0.05270	-0.051300	0.012000	6.99e-01	0.928000
Nuclear import of Rev protein	24	9.05e-01	9.61e-01	0.05250	-0.030800	0.042500	7.94e-01	0.718000
HATs acetylate histones	64	7.72e-01	8.91e-01	0.05210	-0.046900	-0.022500	5.17e-01	0.755000
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	12	9.53e-01	9.87e-01	0.05190	0.018800	0.048300	9.10e-01	0.772000
Signaling by RAF1 mutants	34	8.73e-01	9.50e-01	0.05180	0.050700	0.010800	6.09e-01	0.913000
Metabolism	1438	6.17e-03	4.90e-02	0.05180	0.021100	-0.047300	1.94e-01	0.003600
Interleukin-4 and Interleukin-13 signaling	82	7.22e-01	8.64e-01	0.05170	0.028300	0.043300	6.58e-01	0.499000
PI3K/AKT Signaling in Cancer	81	7.25e-01	8.66e-01	0.05160	-0.025700	0.044800	6.90e-01	0.487000
RAB GEFs exchange GTP for GDP on RABs	78	7.35e-01	8.72e-01	0.05140	-0.045800	0.023200	4.85e-01	0.723000
Nervous system development	412	2.17e-01	4.66e-01	0.05070	0.032900	0.038500	2.56e-01	0.183000
RNA Polymerase III Transcription Initiation	28	9.00e-01	9.58e-01	0.05020	0.048400	-0.013400	6.58e-01	0.902000
Mitotic Prophase	66	7.81e-01	8.97e-01	0.05020	-0.012000	0.048700	8.66e-01	0.494000
RNA Polymerase III Transcription Initiation From Type 3 Promoter	23	9.19e-01	9.71e-01	0.04970	0.048000	0.012900	6.90e-01	0.915000
Factors involved in megakaryocyte development and platelet production	96	7.06e-01	8.53e-01	0.04940	0.037800	0.031900	5.23e-01	0.590000
Mitochondrial translation initiation	64	7.93e-01	9.05e-01	0.04930	-0.036100	-0.033600	6.18e-01	0.643000
Sema3A PAK dependent Axon repulsion	15	9.47e-01	9.86e-01	0.04920	0.049200	0.002020	7.42e-01	0.989000
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	47	8.47e-01	9.39e-01	0.04870	-0.047400	0.011100	5.75e-01	0.895000
Constitutive Signaling by NOTCH1 PEST Domain Mutants	47	8.47e-01	9.39e-01	0.04870	-0.047400	0.011100	5.75e-01	0.895000
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	47	8.47e-01	9.39e-01	0.04870	-0.047400	0.011100	5.75e-01	0.895000
Signaling by NOTCH1 PEST Domain Mutants in Cancer	47	8.47e-01	9.39e-01	0.04870	-0.047400	0.011100	5.75e-01	0.895000
Signaling by NOTCH1 in Cancer	47	8.47e-01	9.39e-01	0.04870	-0.047400	0.011100	5.75e-01	0.895000
RHO GTPases Activate ROCKs	18	9.38e-01	9.83e-01	0.04860	0.046800	0.013200	7.31e-01	0.923000
Initiation of Nuclear Envelope (NE) Reformation	18	9.39e-01	9.83e-01	0.04850	0.047700	0.008480	7.26e-01	0.950000
RNA Polymerase II Transcription	895	6.06e-02	2.06e-01	0.04760	0.004220	0.047400	8.34e-01	0.018300
SUMOylation of DNA damage response and repair proteins	56	8.30e-01	9.30e-01	0.04720	0.047200	0.001560	5.42e-01	0.984000
Regulation of RUNX1 Expression and Activity	16	9.48e-01	9.86e-01	0.04710	-0.028600	0.037400	8.43e-01	0.795000
Interleukin-1 signaling	79	7.76e-01	8.94e-01	0.04640	0.042100	0.019500	5.18e-01	0.765000
Signaling by SCF-KIT	42	8.80e-01	9.53e-01	0.04520	0.040400	0.020300	6.51e-01	0.820000
Collagen formation	69	8.11e-01	9.17e-01	0.04510	0.014200	-0.042900	8.39e-01	0.539000
Nuclear Envelope Breakdown	41	8.83e-01	9.54e-01	0.04510	0.017900	0.041400	8.43e-01	0.647000
Paradoxical activation of RAF signaling by kinase inactive BRAF	37	8.98e-01	9.58e-01	0.04420	0.023500	-0.037400	8.05e-01	0.694000
Signaling by RAS mutants	37	8.98e-01	9.58e-01	0.04420	0.023500	-0.037400	8.05e-01	0.694000
Signaling by moderate kinase activity BRAF mutants	37	8.98e-01	9.58e-01	0.04420	0.023500	-0.037400	8.05e-01	0.694000
Signaling downstream of RAS mutants	37	8.98e-01	9.58e-01	0.04420	0.023500	-0.037400	8.05e-01	0.694000
RA biosynthesis pathway	13	9.63e-01	9.88e-01	0.04410	0.026800	0.035100	8.67e-01	0.827000
mRNA Splicing - Minor Pathway	37	9.00e-01	9.58e-01	0.04370	0.007840	-0.043000	9.34e-01	0.651000
Formation of RNA Pol II elongation complex	42	8.87e-01	9.55e-01	0.04370	-0.041800	-0.012500	6.39e-01	0.889000
RNA Polymerase II Transcription Elongation	42	8.87e-01	9.55e-01	0.04370	-0.041800	-0.012500	6.39e-01	0.889000
NRIF signals cell death from the nucleus	10	9.73e-01	9.88e-01	0.04300	-0.037600	-0.020900	8.37e-01	0.909000
Transport of Mature mRNA Derived from an Intronless Transcript	30	9.21e-01	9.72e-01	0.04280	-0.040700	0.013500	7.00e-01	0.898000
SUMOylation of intracellular receptors	25	9.34e-01	9.82e-01	0.04280	0.039100	-0.017400	7.35e-01	0.880000
Signaling by GPCR	407	3.42e-01	5.90e-01	0.04260	-0.038000	0.019300	1.92e-01	0.507000
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	9.74e-01	9.88e-01	0.04220	-0.033300	-0.025900	8.55e-01	0.887000
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	22	9.44e-01	9.85e-01	0.04180	-0.041100	-0.007340	7.39e-01	0.953000
RNA Pol II CTD phosphorylation and interaction with CE	20	9.51e-01	9.86e-01	0.04110	-0.040300	0.008210	7.55e-01	0.949000
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	20	9.51e-01	9.86e-01	0.04110	-0.040300	0.008210	7.55e-01	0.949000
RNA Polymerase III Transcription Initiation From Type 2 Promoter	19	9.53e-01	9.87e-01	0.04110	0.033700	-0.023400	7.99e-01	0.860000
Transcription of the HIV genome	53	8.77e-01	9.52e-01	0.04070	-0.040600	0.003300	6.10e-01	0.967000
Signal amplification	24	9.43e-01	9.85e-01	0.04040	-0.039600	-0.007730	7.37e-01	0.948000
Signal Transduction	1627	3.38e-02	1.44e-01	0.04010	-0.038500	0.011300	1.26e-02	0.465000
Viral Messenger RNA Synthesis	29	9.33e-01	9.82e-01	0.04010	-0.032100	0.024100	7.65e-01	0.823000
Death Receptor Signalling	112	7.66e-01	8.88e-01	0.04000	0.013600	-0.037600	8.04e-01	0.492000
Transcriptional Regulation by TP53	297	5.09e-01	7.19e-01	0.03940	0.035800	-0.016400	2.91e-01	0.628000
Cellular responses to stress	364	4.52e-01	6.87e-01	0.03880	0.025200	0.029500	4.12e-01	0.337000
Epigenetic regulation of gene expression	70	8.58e-01	9.39e-01	0.03840	0.003250	-0.038200	9.63e-01	0.581000
Gene expression (Transcription)	993	1.37e-01	3.51e-01	0.03820	0.002390	0.038100	9.01e-01	0.046500
Activation of G protein gated Potassium channels	16	9.66e-01	9.88e-01	0.03780	0.017000	-0.033800	9.06e-01	0.815000
G protein gated Potassium channels	16	9.66e-01	9.88e-01	0.03780	0.017000	-0.033800	9.06e-01	0.815000
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	16	9.66e-01	9.88e-01	0.03780	0.017000	-0.033800	9.06e-01	0.815000
Synthesis of PIPs at the plasma membrane	51	8.97e-01	9.58e-01	0.03780	-0.017800	0.033300	8.26e-01	0.681000
Adrenaline,noradrenaline inhibits insulin secretion	18	9.63e-01	9.88e-01	0.03730	-0.007710	-0.036500	9.55e-01	0.789000
Cellular responses to external stimuli	369	4.78e-01	7.04e-01	0.03720	0.029300	0.022900	3.38e-01	0.453000
Formation of Incision Complex in GG-NER	32	9.37e-01	9.83e-01	0.03700	0.002410	-0.036900	9.81e-01	0.718000
PTEN Regulation	118	7.95e-01	9.05e-01	0.03620	-0.005430	-0.035700	9.19e-01	0.504000
L1CAM interactions	85	8.49e-01	9.39e-01	0.03590	-0.025200	0.025500	6.88e-01	0.685000
SUMOylation of SUMOylation proteins	23	9.57e-01	9.88e-01	0.03580	-0.026900	0.023600	8.24e-01	0.844000
Interleukin-1 family signaling	104	8.22e-01	9.25e-01	0.03560	0.028400	0.021400	6.17e-01	0.706000
Diseases associated with glycosaminoglycan metabolism	33	9.42e-01	9.84e-01	0.03480	0.007020	0.034100	9.44e-01	0.735000
Interconversion of nucleotide di- and triphosphates	22	9.61e-01	9.88e-01	0.03460	-0.016400	0.030400	8.94e-01	0.805000
G alpha (z) signalling events	35	9.41e-01	9.84e-01	0.03410	-0.034000	-0.001250	7.28e-01	0.990000
MET activates PTK2 signaling	17	9.71e-01	9.88e-01	0.03380	-0.033800	-0.000508	8.10e-01	0.997000
APC-Cdc20 mediated degradation of Nek2A	20	9.67e-01	9.88e-01	0.03340	0.020400	-0.026500	8.75e-01	0.838000
Inactivation of APC/C via direct inhibition of the APC/C complex	19	9.70e-01	9.88e-01	0.03260	-0.019900	-0.025800	8.81e-01	0.846000
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	9.70e-01	9.88e-01	0.03260	-0.019900	-0.025800	8.81e-01	0.846000
Post-translational protein modification	1006	2.35e-01	4.86e-01	0.03240	-0.028200	0.015900	1.38e-01	0.405000
Anchoring of the basal body to the plasma membrane	81	8.86e-01	9.55e-01	0.03170	-0.029900	0.010500	6.42e-01	0.870000
Nitric oxide stimulates guanylate cyclase	19	9.74e-01	9.88e-01	0.03040	0.023400	0.019400	8.60e-01	0.883000
Activation of kainate receptors upon glutamate binding	21	9.71e-01	9.88e-01	0.03040	-0.007040	-0.029500	9.55e-01	0.815000
Generic Transcription Pathway	798	3.63e-01	6.09e-01	0.03020	0.003710	0.029900	8.61e-01	0.157000
G alpha (i) signalling events	190	7.91e-01	9.04e-01	0.02890	-0.020700	0.020100	6.24e-01	0.634000
Metabolism of lipids	525	5.61e-01	7.54e-01	0.02780	-0.008760	-0.026300	7.34e-01	0.307000
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	9.63e-01	9.88e-01	0.02780	0.027500	-0.003890	7.85e-01	0.969000
Diseases of mitotic cell cycle	33	9.63e-01	9.88e-01	0.02780	0.027500	-0.003890	7.85e-01	0.969000
DNA Damage Recognition in GG-NER	27	9.70e-01	9.88e-01	0.02760	0.001780	-0.027600	9.87e-01	0.804000
Developmental Biology	613	5.20e-01	7.29e-01	0.02740	0.001420	0.027400	9.53e-01	0.253000
Vitamin B5 (pantothenate) metabolism	13	9.87e-01	9.97e-01	0.02640	0.017000	-0.020200	9.16e-01	0.900000
Transport of Mature mRNAs Derived from Intronless Transcripts	31	9.69e-01	9.88e-01	0.02620	-0.017600	0.019400	8.66e-01	0.852000
Collagen chain trimerization	33	9.70e-01	9.88e-01	0.02500	-0.023800	-0.007690	8.13e-01	0.939000
PIP3 activates AKT signaling	218	8.20e-01	9.24e-01	0.02480	-0.020200	0.014500	6.09e-01	0.714000
GPCR downstream signalling	377	7.22e-01	8.64e-01	0.02440	-0.020100	0.013700	5.06e-01	0.650000
B-WICH complex positively regulates rRNA expression	24	9.81e-01	9.94e-01	0.02310	0.022600	-0.005010	8.48e-01	0.966000
Metabolism of proteins	1380	3.81e-01	6.28e-01	0.02300	-0.021900	0.006880	1.85e-01	0.678000
Cell-extracellular matrix interactions	14	9.89e-01	9.97e-01	0.02290	0.022000	-0.006440	8.87e-01	0.967000
Centrosome maturation	70	9.47e-01	9.86e-01	0.02280	-0.000492	-0.022800	9.94e-01	0.742000
Recruitment of mitotic centrosome proteins and complexes	70	9.47e-01	9.86e-01	0.02280	-0.000492	-0.022800	9.94e-01	0.742000
Recruitment of NuMA to mitotic centrosomes	69	9.49e-01	9.86e-01	0.02260	-0.016200	-0.015800	8.16e-01	0.821000
SUMOylation of ubiquitinylation proteins	28	9.80e-01	9.94e-01	0.02190	-0.000877	0.021900	9.94e-01	0.841000
eNOS activation	10	9.93e-01	9.98e-01	0.02170	-0.021300	0.004250	9.07e-01	0.981000
Glycosaminoglycan metabolism	89	9.41e-01	9.84e-01	0.02140	0.020300	-0.006850	7.41e-01	0.911000
FLT3 Signaling	226	8.61e-01	9.42e-01	0.02120	-0.018700	0.009930	6.30e-01	0.798000
SARS-CoV Infections	67	9.58e-01	9.88e-01	0.02060	-0.011500	0.017100	8.71e-01	0.809000
Loss of Nlp from mitotic centrosomes	60	9.64e-01	9.88e-01	0.02020	-0.019100	0.006610	7.99e-01	0.930000
Loss of proteins required for interphase microtubule organization from the centrosome	60	9.64e-01	9.88e-01	0.02020	-0.019100	0.006610	7.99e-01	0.930000
Neddylation	181	9.12e-01	9.66e-01	0.01860	0.002440	0.018400	9.55e-01	0.670000
Signaling by Nuclear Receptors	185	9.13e-01	9.66e-01	0.01830	-0.015700	0.009300	7.14e-01	0.828000
Hedgehog 'off' state	84	9.60e-01	9.88e-01	0.01800	-0.016700	0.006700	7.92e-01	0.916000
Rap1 signalling	15	9.93e-01	9.98e-01	0.01770	0.005570	0.016800	9.70e-01	0.910000
Prefoldin mediated transfer of substrate to CCT/TriC	20	9.91e-01	9.97e-01	0.01770	-0.017700	0.000436	8.91e-01	0.997000
Synthesis of glycosylphosphatidylinositol (GPI)	14	9.94e-01	9.98e-01	0.01730	-0.015900	0.006930	9.18e-01	0.964000
PI Metabolism	75	9.72e-01	9.88e-01	0.01600	0.015900	-0.002080	8.13e-01	0.975000
Pre-NOTCH Transcription and Translation	30	9.89e-01	9.97e-01	0.01540	0.003200	-0.015000	9.76e-01	0.887000
ECM proteoglycans	41	9.86e-01	9.97e-01	0.01490	0.002760	-0.014700	9.76e-01	0.871000
Disease	1014	7.43e-01	8.77e-01	0.01460	-0.004100	-0.014100	8.29e-01	0.459000
MAPK family signaling cascades	250	9.38e-01	9.83e-01	0.01320	-0.013100	-0.001950	7.23e-01	0.958000
CTLA4 inhibitory signaling	21	9.95e-01	9.98e-01	0.01300	0.000517	0.013000	9.97e-01	0.918000
Collagen biosynthesis and modifying enzymes	51	9.89e-01	9.97e-01	0.01230	0.012000	-0.002680	8.82e-01	0.974000
Postmitotic nuclear pore complex (NPC) reformation	20	9.96e-01	9.98e-01	0.01210	0.004150	0.011300	9.74e-01	0.930000
AURKA Activation by TPX2	62	9.90e-01	9.97e-01	0.01020	0.005490	-0.008610	9.40e-01	0.907000
Signalling to RAS	18	9.98e-01	9.99e-01	0.00865	0.008550	0.001350	9.50e-01	0.992000
Glutathione conjugation	27	9.98e-01	9.99e-01	0.00659	0.000814	0.006540	9.94e-01	0.953000
RAF/MAP kinase cascade	212	9.87e-01	9.97e-01	0.00646	-0.001680	0.006240	9.67e-01	0.876000
MAPK1/MAPK3 signaling	217	9.99e-01	9.99e-01	0.00205	0.001580	-0.001310	9.68e-01	0.974000

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Detailed Gene set reports

Glucuronidation

Glucuronidation

metric	value
setSize	11
pMANOVA	2.86e-05
p.adjustMANOVA	0.000876
s.dist	0.797
s.rna	0.524
s.meth	0.6
p.rna	0.0026
p.meth	0.000564

Top 20 genes

Gene	rna	meth
UGT1A10	4744.5	4839.5
UGT1A7	4744.5	4839.5
UGT1A8	4744.5	4839.5
UGT1A9	4744.5	4839.5
UGT3A1	5863.5	1191.5
UGT3A2	5863.5	1191.5
UGT1A6	2631.0	2566.0
SLC35D1	2962.0	1773.0
UGP2	1026.0	4361.0

Click HERE to show all gene set members

All member genes

	rna	meth
ABHD10	-645.0	3537.0
SLC35D1	2962.0	1773.0
UGDH	-2244.0	-5689.0
UGP2	1026.0	4361.0
UGT1A10	4744.5	4839.5
UGT1A6	2631.0	2566.0
UGT1A7	4744.5	4839.5
UGT1A8	4744.5	4839.5
UGT1A9	4744.5	4839.5
UGT3A1	5863.5	1191.5
UGT3A2	5863.5	1191.5

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Interferon alpha/beta signaling

Interferon alpha/beta signaling

metric	value
setSize	42
pMANOVA	2.73e-14
p.adjustMANOVA	3.43e-11
s.dist	0.704
s.rna	0.649
s.meth	-0.273
p.rna	3.43e-13
p.meth	0.00218

Top 20 genes

Gene	rna	meth
IFITM1	5738.0	-6539.0
IFITM2	5738.0	-6539.0
IFITM3	5738.0	-6539.0
IRF9	5855.0	-6178.0
PTPN6	5613.0	-6292.0
OASL	5755.0	-6035.0
IRF8	4706.0	-6439.0
IRF1	5785.0	-5134.0
OAS3	4679.0	-6127.0
PSMB8	5777.0	-4591.0
BST2	5841.0	-4428.0
TYK2	4837.0	-4799.0
OAS2	5522.0	-3966.0
OAS1	5879.0	-3635.0
IRF3	4327.0	-4405.0
SOCS3	3782.0	-5000.0
USP18	5822.5	-3137.5
SAMHD1	3880.0	-4187.0
XAF1	5834.0	-2359.0
RNASEL	3211.0	-4135.0

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All member genes

	rna	meth
ADAR	1547.0	-4623.0
BST2	5841.0	-4428.0
EGR1	-5146.0	-4013.0
IFI27	1648.0	-843.0
IFI35	4758.0	925.0
IFIT2	5886.0	-1112.0
IFIT3	5914.0	3544.0
IFITM1	5738.0	-6539.0
IFITM2	5738.0	-6539.0
IFITM3	5738.0	-6539.0
IFNAR1	4438.0	651.0
IFNAR2	244.0	-3762.0
IP6K2	955.0	1981.0
IRF1	5785.0	-5134.0
IRF3	4327.0	-4405.0
IRF4	2846.0	-480.0
IRF5	4484.0	-1708.0
IRF6	1601.0	990.0
IRF7	5882.0	-1336.0
IRF8	4706.0	-6439.0
IRF9	5855.0	-6178.0
ISG20	465.0	-2104.0
JAK1	-2473.0	1184.0
MX1	5884.0	4809.0
OAS1	5879.0	-3635.0
OAS2	5522.0	-3966.0
OAS3	4679.0	-6127.0
OASL	5755.0	-6035.0
PSMB8	5777.0	-4591.0
PTPN1	1274.0	-1549.0
PTPN11	-4701.0	-1813.0
PTPN6	5613.0	-6292.0
RNASEL	3211.0	-4135.0
RSAD2	5842.0	3235.0
SAMHD1	3880.0	-4187.0
SOCS1	4792.0	1777.0
SOCS3	3782.0	-5000.0
STAT1	5541.0	-1367.0
STAT2	5617.0	-554.0
TYK2	4837.0	-4799.0
USP18	5822.5	-3137.5
XAF1	5834.0	-2359.0

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Classical antibody-mediated complement activation

Classical antibody-mediated complement activation

metric	value
setSize	10
pMANOVA	0.000674
p.adjustMANOVA	0.0119
s.dist	0.698
s.rna	0.684
s.meth	-0.139
p.rna	0.000182
p.meth	0.446

Top 20 genes

Gene	rna	meth
C1QA	5781.0	-5137.0
C1QC	5155.0	-4129.0
C1QB	5296.0	-3155.0
C1R	4931.0	-3311.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5

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All member genes

	rna	meth
C1QA	5781.0	-5137.0
C1QB	5296.0	-3155.0
C1QC	5155.0	-4129.0
C1R	4931.0	-3311.0
C1S	-830.0	-3011.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5
IGKC	2844.0	3129.0

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Initial triggering of complement

Initial triggering of complement

metric	value
setSize	19
pMANOVA	1.21e-06
p.adjustMANOVA	9.52e-05
s.dist	0.691
s.rna	0.614
s.meth	-0.318
p.rna	3.63e-06
p.meth	0.0166

Top 20 genes

Gene	rna	meth
CFB	5897.0	-6790.0
C4A	5630.5	-5845.5
C4B	5630.5	-5845.5
C1QA	5781.0	-5137.0
C1QC	5155.0	-4129.0
C3	5581.0	-3427.0
GZMM	3717.0	-5039.0
C1QB	5296.0	-3155.0
C1R	4931.0	-3311.0
C2	5840.0	-639.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5

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All member genes

	rna	meth
C1QA	5781.0	-5137.0
C1QB	5296.0	-3155.0
C1QC	5155.0	-4129.0
C1R	4931.0	-3311.0
C1S	-830.0	-3011.0
C2	5840.0	-639.0
C3	5581.0	-3427.0
C4A	5630.5	-5845.5
C4B	5630.5	-5845.5
CFB	5897.0	-6790.0
CFD	-4728.0	-5054.0
COLEC11	5689.0	1178.0
GZMM	3717.0	-5039.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5
IGKC	2844.0	3129.0
MASP1	-4514.0	-4165.0

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Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

metric	value
setSize	10
pMANOVA	0.00165
p.adjustMANOVA	0.022
s.dist	0.654
s.rna	0.637
s.meth	-0.144
p.rna	0.000482
p.meth	0.43

Top 20 genes

Gene	rna	meth
CD4	4661.0	-5138.0
LCK	4478.0	-4146.0
PAG1	4598.0	-3754.0
CSK	1995.0	-3159.0
HLA-DQB1	3651.5	-1685.5
HLA-DQB2	3651.5	-1685.5
PTPN22	5025.0	-777.0
CD247	271.0	-4228.0

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All member genes

	rna	meth
CD247	271.0	-4228.0
CD4	4661.0	-5138.0
CSK	1995.0	-3159.0
HLA-DQB1	3651.5	-1685.5
HLA-DQB2	3651.5	-1685.5
LCK	4478.0	-4146.0
PAG1	4598.0	-3754.0
PTPN22	5025.0	-777.0
PTPRC	5606.0	4751.0
PTPRJ	3987.0	1959.0

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LGI-ADAM interactions

LGI-ADAM interactions

metric	value
setSize	11
pMANOVA	0.000986
p.adjustMANOVA	0.0164
s.dist	0.648
s.rna	-0.593
s.meth	-0.261
p.rna	0.000654
p.meth	0.134

Top 20 genes

Gene	rna	meth
ADAM11	-5357	-6267
LGI4	-5457	-6013
STX1B	-4990	-4401
LGI2	-4436	-4758
STX1A	-1340	-6407
LGI3	-3244	-1778
DLG4	-301	-6750

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All member genes

	rna	meth
ADAM11	-5357	-6267
ADAM22	-1952	4711
ADAM23	-3368	1790
CACNG2	-1482	1366
DLG4	-301	-6750
LGI1	-5602	1332
LGI2	-4436	-4758
LGI3	-3244	-1778
LGI4	-5457	-6013
STX1A	-1340	-6407
STX1B	-4990	-4401

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Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

metric	value
setSize	10
pMANOVA	0.00205
p.adjustMANOVA	0.0258
s.dist	0.642
s.rna	-0.633
s.meth	0.11
p.rna	0.000529
p.meth	0.549

Top 20 genes

Gene	rna	meth
LRP6	-4228	3633
WNT5A	-4875	2558
WNT9A	-4360	183
SFRP2	-1291	467
SFRP1	-100	70

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All member genes

	rna	meth
KREMEN1	-5746.0	-4252.0
LRP5	-5463.5	-4388.5
LRP6	-4228.0	3633.0
SFRP1	-100.0	70.0
SFRP2	-1291.0	467.0
SOST	-5611.0	-2379.0
WIF1	-5743.0	-911.0
WNT4	991.0	2006.0
WNT5A	-4875.0	2558.0
WNT9A	-4360.0	183.0

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Creation of C4 and C2 activators

Creation of C4 and C2 activators

metric	value
setSize	12
pMANOVA	0.00155
p.adjustMANOVA	0.0214
s.dist	0.599
s.rna	0.585
s.meth	-0.132
p.rna	0.000453
p.meth	0.43

Top 20 genes

Gene	rna	meth
C1QA	5781.0	-5137.0
C1QC	5155.0	-4129.0
C1QB	5296.0	-3155.0
C1R	4931.0	-3311.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5

Click HERE to show all gene set members

All member genes

	rna	meth
C1QA	5781.0	-5137.0
C1QB	5296.0	-3155.0
C1QC	5155.0	-4129.0
C1R	4931.0	-3311.0
C1S	-830.0	-3011.0
COLEC11	5689.0	1178.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5
IGKC	2844.0	3129.0
MASP1	-4514.0	-4165.0

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Signaling by Activin

Signaling by Activin

metric	value
setSize	10
pMANOVA	0.00506
p.adjustMANOVA	0.0441
s.dist	0.593
s.rna	-0.527
s.meth	0.273
p.rna	0.00392
p.meth	0.135

Top 20 genes

Gene	rna	meth
ACVR2A	-4325	4326
ACVR1B	-3250	3777
INHBA	-2246	3074
SMAD2	-1178	4318
INHBB	-5770	577
SMAD4	-1378	498

Click HERE to show all gene set members

All member genes

	rna	meth
ACVR1B	-3250	3777
ACVR2A	-4325	4326
ACVR2B	-4836	-1430
FST	-3826	-579
FSTL3	2368	-1960
INHBA	-2246	3074
INHBB	-5770	577
SMAD2	-1178	4318
SMAD3	-5777	-6039
SMAD4	-1378	498

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Removal of the Flap Intermediate

Removal of the Flap Intermediate

metric	value
setSize	11
pMANOVA	0.00312
p.adjustMANOVA	0.0329
s.dist	0.591
s.rna	0.439
s.meth	-0.396
p.rna	0.0118
p.meth	0.0229

Top 20 genes

Gene	rna	meth
RPA2	3762	-6294
POLD2	3426	-6387
PRIM1	3555	-5621
DNA2	2854	-6487
PCNA	5031	-3646
POLD1	1787	-6671
POLA2	1693	-4205
RPA1	507	-1296

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	2854	-6487
PCNA	5031	-3646
POLA1	5459	3646
POLA2	1693	-4205
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
PRIM1	3555	-5621
PRIM2	-2297	-36
RPA1	507	-1296
RPA2	3762	-6294

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PI-3K cascade:FGFR2

PI-3K cascade:FGFR2

metric	value
setSize	14
pMANOVA	8e-04
p.adjustMANOVA	0.0138
s.dist	0.582
s.rna	-0.511
s.meth	0.279
p.rna	0.000927
p.meth	0.0707

Top 20 genes

Gene	rna	meth
FGF9	-4244	3949
GAB1	-5397	3092
GRB2	-5470	1760
FGF10	-2329	4120
FGF18	-3203	1227
FRS2	-4033	581
FGF7	-2014	1061
FGF16	-148	1425

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All member genes

	rna	meth
FGF1	-4273	-1733
FGF10	-2329	4120
FGF16	-148	1425
FGF18	-3203	1227
FGF2	-4806	-2322
FGF7	-2014	1061
FGF9	-4244	3949
FGFR2	-4480	-2755
FRS2	-4033	581
GAB1	-5397	3092
GRB2	-5470	1760
PIK3CA	-1569	-1607
PIK3R1	5649	2682
PTPN11	-4701	-1813

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PI-3K cascade:FGFR4

PI-3K cascade:FGFR4

metric	value
setSize	11
pMANOVA	0.00392
p.adjustMANOVA	0.039
s.dist	0.579
s.rna	-0.511
s.meth	0.274
p.rna	0.00337
p.meth	0.116

Top 20 genes

Gene	rna	meth
FGF9	-4244	3949
GAB1	-5397	3092
GRB2	-5470	1760
FGF18	-3203	1227
FRS2	-4033	581
FGF16	-148	1425

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All member genes

	rna	meth
FGF1	-4273	-1733
FGF16	-148	1425
FGF18	-3203	1227
FGF2	-4806	-2322
FGF9	-4244	3949
FRS2	-4033	581
GAB1	-5397	3092
GRB2	-5470	1760
PIK3CA	-1569	-1607
PIK3R1	5649	2682
PTPN11	-4701	-1813

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Cholesterol biosynthesis

Cholesterol biosynthesis

metric	value
setSize	20
pMANOVA	4.46e-05
p.adjustMANOVA	0.00127
s.dist	0.579
s.rna	-0.539
s.meth	-0.211
p.rna	3.05e-05
p.meth	0.102

Top 20 genes

Gene	rna	meth
MVK	-4135	-6706
DHCR24	-4658	-4197
ACAT2	-3336	-4926
PMVK	-3675	-4184
SQLE	-4277	-2915
SC5D	-5054	-2341
EBP	-3829	-2780
NSDHL	-3050	-3030
FDPS	-2925	-2692
HSD17B7	-3486	-2034
HMGCR	-1208	-2822
MVD	-4079	-781
LBR	-865	-2702
LSS	-324	-5741
DHCR7	-885	-1942

Click HERE to show all gene set members

All member genes

	rna	meth
ACAT2	-3336	-4926
CYP51A1	-4808	883
DHCR24	-4658	-4197
DHCR7	-885	-1942
EBP	-3829	-2780
FDFT1	3359	-617
FDPS	-2925	-2692
HMGCR	-1208	-2822
HMGCS1	-4636	3168
HSD17B7	-3486	-2034
IDI1	-5076	177
LBR	-865	-2702
LSS	-324	-5741
MSMO1	-4818	2618
MVD	-4079	-781
MVK	-4135	-6706
NSDHL	-3050	-3030
PMVK	-3675	-4184
SC5D	-5054	-2341
SQLE	-4277	-2915

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Removal of the Flap Intermediate from the C-strand

Removal of the Flap Intermediate from the C-strand

metric	value
setSize	12
pMANOVA	0.0028
p.adjustMANOVA	0.0308
s.dist	0.571
s.rna	0.481
s.meth	-0.309
p.rna	0.00395
p.meth	0.0642

Top 20 genes

Gene	rna	meth
RPA2	3762	-6294
POLD2	3426	-6387
TINF2	5212	-3958
DNA2	2854	-6487
PCNA	5031	-3646
TERF2	2852	-5885
POLD1	1787	-6671
RPA1	507	-1296

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All member genes

	rna	meth
DNA2	2854	-6487
PCNA	5031	-3646
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
POT1	1342	1620
RPA1	507	-1296
RPA2	3762	-6294
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958
WRN	-258	2822

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---

HSF1-dependent transactivation

HSF1-dependent transactivation

metric	value
setSize	26
pMANOVA	3.16e-06
p.adjustMANOVA	0.00015
s.dist	0.57
s.rna	-0.56
s.meth	-0.109
p.rna	7.74e-07
p.meth	0.336

Top 20 genes

Gene	rna	meth
RPTOR	-5347	-4452
HSP90AB1	-4547	-4818
CAMK2B	-5549	-3805
CRYBA4	-3346	-6091
DNAJB1	-3932	-5156
HSP90AA1	-3976	-4716
CAMK2G	-5433	-3326
MLST8	-3933	-4526
HSPB8	-5410	-3224
CAMK2A	-3324	-4446
HSBP1	-2813	-4293
FKBP4	-5216	-2250
MTOR	-3007	-3650
HSPH1	-4329	-1922

Click HERE to show all gene set members

All member genes

	rna	meth
AKT1S1	438.0	-4474.0
CAMK2A	-3324.0	-4446.0
CAMK2B	-5549.0	-3805.0
CAMK2D	-3579.0	4750.0
CAMK2G	-5433.0	-3326.0
COL4A6	-2343.0	4237.0
CREBBP	644.0	895.0
CRYBA4	-3346.0	-6091.0
DNAJB1	-3932.0	-5156.0
DNAJB6	-3589.0	1200.0
EP300	-3931.0	1420.0
FKBP4	-5216.0	-2250.0
HSBP1	-2813.0	-4293.0
HSP90AA1	-3976.0	-4716.0
HSP90AB1	-4547.0	-4818.0
HSPA1A	-5536.5	2028.5
HSPA1B	-5536.5	2028.5
HSPA8	-3766.0	1540.0
HSPB8	-5410.0	-3224.0
HSPH1	-4329.0	-1922.0
MLST8	-3933.0	-4526.0
MTOR	-3007.0	-3650.0
PTGES3	2504.0	-354.0
RPTOR	-5347.0	-4452.0
SERPINH1	-4358.0	1896.0
TNFRSF21	5722.0	424.0

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Processive synthesis on the lagging strand

Processive synthesis on the lagging strand

metric	value
setSize	12
pMANOVA	0.00309
p.adjustMANOVA	0.0329
s.dist	0.566
s.rna	0.476
s.meth	-0.307
p.rna	0.0043
p.meth	0.0658

Top 20 genes

Gene	rna	meth
RPA2	3762	-6294
POLD2	3426	-6387
PRIM1	3555	-5621
DNA2	2854	-6487
PCNA	5031	-3646
POLD1	1787	-6671
POLA2	1693	-4205
RPA1	507	-1296

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	2854	-6487
LIG1	5261	3019
PCNA	5031	-3646
POLA1	5459	3646
POLA2	1693	-4205
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
PRIM1	3555	-5621
PRIM2	-2297	-36
RPA1	507	-1296
RPA2	3762	-6294

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	37
pMANOVA	2.92e-08
p.adjustMANOVA	5.24e-06
s.dist	0.56
s.rna	0.558
s.meth	0.0462
p.rna	4.32e-09
p.meth	0.627

Top 20 genes

Gene	rna	meth
RPS15A	5268	4133
RPS27L	4975	3865
RPL36A	4562	3358
RPS4X	4607	3294
RPL22L1	4911	2808
RPS24	4827	2701
RPS5	3705	2654
RPL30	4338	1921
RPS9	5029	1478
RPS23	2500	2927
RPS6	2334	2042
RPL31	2917	1164
RPL5	1979	1062
RPL3	4796	344
RPL37A	2758	563

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All member genes

	rna	meth
EEF1A1	5603	-2195
EEF2	71	-327
FAU	3553	-1986
RPL10	4592	-4690
RPL11	5333	-4485
RPL14	1821	-2318
RPL15	5231	-1145
RPL22	1872	-5539
RPL22L1	4911	2808
RPL26	1504	-4189
RPL28	724	-325
RPL3	4796	344
RPL30	4338	1921
RPL31	2917	1164
RPL32	3931	-1134
RPL34	2949	-1477
RPL36A	4562	3358
RPL37	3526	-3491
RPL37A	2758	563
RPL38	4188	-63
RPL3L	-1486	-5367
RPL5	1979	1062
RPL7	2763	-867
RPL8	2671	-5143
RPS14	1683	-3702
RPS15	2889	-2037
RPS15A	5268	4133
RPS19	4035	-2018
RPS23	2500	2927
RPS24	4827	2701
RPS26	1602	-2722
RPS27	4237	-3983
RPS27L	4975	3865
RPS4X	4607	3294
RPS5	3705	2654
RPS6	2334	2042
RPS9	5029	1478

---

---

STING mediated induction of host immune responses

STING mediated induction of host immune responses

metric	value
setSize	11
pMANOVA	0.00676
p.adjustMANOVA	0.053
s.dist	0.55
s.rna	0.433
s.meth	-0.339
p.rna	0.0128
p.meth	0.0518

Top 20 genes

Gene	rna	meth
TREX1	4826	-6261
DDX41	3646	-5447
IRF3	4327	-4405
TBK1	3838	-4315
NLRC3	2653	-5661
TRIM21	5467	-1780
STAT6	1097	-5959

Click HERE to show all gene set members

All member genes

	rna	meth
DDX41	3646.0	-5447.0
DTX4	-5690.0	426.0
IFI16	5915.5	4862.5
IRF3	4327.0	-4405.0
NLRC3	2653.0	-5661.0
STAT6	1097.0	-5959.0
TBK1	3838.0	-4315.0
TREX1	4826.0	-6261.0
TRIM21	5467.0	-1780.0
XRCC5	2617.0	2240.0
XRCC6	-123.0	-5874.0

---

---

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

metric	value
setSize	11
pMANOVA	0.00715
p.adjustMANOVA	0.0551
s.dist	0.547
s.rna	-0.342
s.meth	0.427
p.rna	0.0497
p.meth	0.0142

Top 20 genes

Gene	rna	meth
TAB2	-3856	4546
TLR4	-2555	4265
MAP3K7	-2447	3651
LY96	-1907	2936
TAB3	-1019	2930
TRAF6	-512	2407
TICAM1	-838	522
CD14	-1693	174

Click HERE to show all gene set members

All member genes

	rna	meth
CD14	-1693.0	174.0
IRAK2	-3406.0	-4795.0
LY96	-1907.0	2936.0
MAP3K7	-2447.0	3651.0
TAB1	-5164.0	-1864.0
TAB2	-3856.0	4546.0
TAB3	-1019.0	2930.0
TICAM1	-838.0	522.0
TICAM2	2072.5	2344.5
TLR4	-2555.0	4265.0
TRAF6	-512.0	2407.0

---

---

TRAF6-mediated induction of TAK1 complex within TLR4 complex

TRAF6-mediated induction of TAK1 complex within TLR4 complex

metric	value
setSize	11
pMANOVA	0.00715
p.adjustMANOVA	0.0551
s.dist	0.547
s.rna	-0.342
s.meth	0.427
p.rna	0.0497
p.meth	0.0142

Top 20 genes

Gene	rna	meth
TAB2	-3856	4546
TLR4	-2555	4265
MAP3K7	-2447	3651
LY96	-1907	2936
TAB3	-1019	2930
TRAF6	-512	2407
TICAM1	-838	522
CD14	-1693	174

Click HERE to show all gene set members

All member genes

	rna	meth
CD14	-1693.0	174.0
IRAK2	-3406.0	-4795.0
LY96	-1907.0	2936.0
MAP3K7	-2447.0	3651.0
TAB1	-5164.0	-1864.0
TAB2	-3856.0	4546.0
TAB3	-1019.0	2930.0
TICAM1	-838.0	522.0
TICAM2	2072.5	2344.5
TLR4	-2555.0	4265.0
TRAF6	-512.0	2407.0

---

---

DNA strand elongation

DNA strand elongation

metric	value
setSize	26
pMANOVA	8.88e-06
p.adjustMANOVA	0.000301
s.dist	0.546
s.rna	0.527
s.meth	-0.144
p.rna	3.3e-06
p.meth	0.205

Top 20 genes

Gene	rna	meth
GINS2	4305	-5918
RPA2	3762	-6294
POLD2	3426	-6387
PRIM1	3555	-5621
DNA2	2854	-6487
PCNA	5031	-3646
MCM3	4996	-2841
POLD1	1787	-6671
RFC5	1809	-5508
POLA2	1693	-4205
MCM2	5312	-1197
RFC3	1846	-3141
RFC2	3304	-1485
MCM6	5516	-812
RPA1	507	-1296

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	2854	-6487
GINS1	4936	2958
GINS2	4305	-5918
GINS3	389	1661
GINS4	3593	251
LIG1	5261	3019
MCM2	5312	-1197
MCM3	4996	-2841
MCM4	5790	632
MCM5	5726	1567
MCM6	5516	-812
PCNA	5031	-3646
POLA1	5459	3646
POLA2	1693	-4205
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
PRIM1	3555	-5621
PRIM2	-2297	-36
RFC1	-669	-520
RFC2	3304	-1485
RFC3	1846	-3141
RFC4	665	859
RFC5	1809	-5508
RPA1	507	-1296
RPA2	3762	-6294

---

---

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

metric	value
setSize	16
pMANOVA	0.00102
p.adjustMANOVA	0.0164
s.dist	0.536
s.rna	-0.402
s.meth	0.354
p.rna	0.00539
p.meth	0.0142

Top 20 genes

Gene	rna	meth
MAPK8	-3888	4721
MAP2K4	-5016	3581
TAB2	-3856	4546
MAP3K7	-2447	3651
MAPK10	-1665	4204
MAPK9	-4686	1217
TAB3	-1019	2930
TRAF6	-512	2407
IKBKG	-806	1427

Click HERE to show all gene set members

All member genes

	rna	meth
IKBKG	-806	1427
IRAK1	76	1848
IRAK2	-3406	-4795
MAP2K4	-5016	3581
MAP2K7	1860	-5477
MAP3K7	-2447	3651
MAPK10	-1665	4204
MAPK8	-3888	4721
MAPK9	-4686	1217
NOD1	525	1835
NOD2	-4270	-1976
TAB1	-5164	-1864
TAB2	-3856	4546
TAB3	-1019	2930
TRAF6	-512	2407
UBE2N	-2359	-190

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	45
pMANOVA	4.65e-09
p.adjustMANOVA	1.17e-06
s.dist	0.534
s.rna	0.523
s.meth	0.11
p.rna	1.33e-09
p.meth	0.202

Top 20 genes

Gene	rna	meth
RPS15A	5268	4133
RPS27L	4975	3865
RPL36A	4562	3358
RPS4X	4607	3294
TRIB3	5795	2584
RPL22L1	4911	2808
ATF4	4324	3096
RPS24	4827	2701
RPS5	3705	2654
ATF2	1818	4690
RPL30	4338	1921
RPS9	5029	1478
RPS23	2500	2927
EIF2S2	2346	2411
CEBPG	1390	3909
RPS6	2334	2042
RPL31	2917	1164
RPL5	1979	1062
RPL3	4796	344
RPL37A	2758	563

Click HERE to show all gene set members

All member genes

	rna	meth
ASNS	5589	-2880
ATF2	1818	4690
ATF3	-3734	2736
ATF4	4324	3096
CEBPB	3954	-771
CEBPG	1390	3909
EIF2AK4	4388	-2844
EIF2S2	2346	2411
FAU	3553	-1986
IMPACT	-3006	-4095
RPL10	4592	-4690
RPL11	5333	-4485
RPL14	1821	-2318
RPL15	5231	-1145
RPL22	1872	-5539
RPL22L1	4911	2808
RPL26	1504	-4189
RPL28	724	-325
RPL3	4796	344
RPL30	4338	1921
RPL31	2917	1164
RPL32	3931	-1134
RPL34	2949	-1477
RPL36A	4562	3358
RPL37	3526	-3491
RPL37A	2758	563
RPL38	4188	-63
RPL3L	-1486	-5367
RPL5	1979	1062
RPL7	2763	-867
RPL8	2671	-5143
RPS14	1683	-3702
RPS15	2889	-2037
RPS15A	5268	4133
RPS19	4035	-2018
RPS23	2500	2927
RPS24	4827	2701
RPS26	1602	-2722
RPS27	4237	-3983
RPS27L	4975	3865
RPS4X	4607	3294
RPS5	3705	2654
RPS6	2334	2042
RPS9	5029	1478
TRIB3	5795	2584

---

---

FRS-mediated FGFR2 signaling

FRS-mediated FGFR2 signaling

metric	value
setSize	15
pMANOVA	0.00164
p.adjustMANOVA	0.022
s.dist	0.534
s.rna	-0.443
s.meth	0.297
p.rna	0.00296
p.meth	0.0465

Top 20 genes

Gene	rna	meth
FGF9	-4244	3949
GRB2	-5470	1760
FGF10	-2329	4120
FGF18	-3203	1227
FRS2	-4033	581
FGF7	-2014	1061
FGF16	-148	1425

Click HERE to show all gene set members

All member genes

	rna	meth
FGF1	-4273	-1733
FGF10	-2329	4120
FGF16	-148	1425
FGF18	-3203	1227
FGF2	-4806	-2322
FGF7	-2014	1061
FGF9	-4244	3949
FGFR2	-4480	-2755
FRS2	-4033	581
GRB2	-5470	1760
HRAS	287	161
KRAS	1494	3596
NRAS	3683	3968
PTPN11	-4701	-1813
SOS1	-3743	-1297

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	40
pMANOVA	4e-08
p.adjustMANOVA	6.27e-06
s.dist	0.533
s.rna	0.533
s.meth	0.024
p.rna	5.48e-09
p.meth	0.793

Top 20 genes

Gene	rna	meth
RPS15A	5268	4133
RPS27L	4975	3865
RPL36A	4562	3358
RPS4X	4607	3294
RPL22L1	4911	2808
RPS24	4827	2701
RPS5	3705	2654
RPL30	4338	1921
RPS9	5029	1478
RPS23	2500	2927
RPS6	2334	2042
SEPSECS	973	3868
RPL31	2917	1164
RPL5	1979	1062
RPL3	4796	344
RPL37A	2758	563

Click HERE to show all gene set members

All member genes

	rna	meth
EEFSEC	2614	-268
FAU	3553	-1986
PSTK	5462	-2848
RPL10	4592	-4690
RPL11	5333	-4485
RPL14	1821	-2318
RPL15	5231	-1145
RPL22	1872	-5539
RPL22L1	4911	2808
RPL26	1504	-4189
RPL28	724	-325
RPL3	4796	344
RPL30	4338	1921
RPL31	2917	1164
RPL32	3931	-1134
RPL34	2949	-1477
RPL36A	4562	3358
RPL37	3526	-3491
RPL37A	2758	563
RPL38	4188	-63
RPL3L	-1486	-5367
RPL5	1979	1062
RPL7	2763	-867
RPL8	2671	-5143
RPS14	1683	-3702
RPS15	2889	-2037
RPS15A	5268	4133
RPS19	4035	-2018
RPS23	2500	2927
RPS24	4827	2701
RPS26	1602	-2722
RPS27	4237	-3983
RPS27L	4975	3865
RPS4X	4607	3294
RPS5	3705	2654
RPS6	2334	2042
RPS9	5029	1478
SECISBP2	1343	-6026
SEPHS2	-602	-4461
SEPSECS	973	3868

---

---

CREB1 phosphorylation through the activation of Adenylate Cyclase

CREB1 phosphorylation through the activation of Adenylate Cyclase

metric	value
setSize	11
pMANOVA	0.00919
p.adjustMANOVA	0.065
s.dist	0.533
s.rna	-0.322
s.meth	0.424
p.rna	0.0643
p.meth	0.0148

Top 20 genes

Gene	rna	meth
ADCY1	-5524	3059
PRKAR2A	-5240	1487
PRKX	-1854	3790
ADCY8	-2010	3082
PRKACB	-851	2158
PRKACA	-4097	232

Click HERE to show all gene set members

All member genes

	rna	meth
ADCY1	-5524	3059
ADCY8	-2010	3082
CALM1	3036	2188
CREB1	2704	3278
PRKACA	-4097	232
PRKACB	-851	2158
PRKAR1A	-4768	-922
PRKAR1B	-3004	-4047
PRKAR2A	-5240	1487
PRKAR2B	1542	2647
PRKX	-1854	3790

---

---

Termination of translesion DNA synthesis

Termination of translesion DNA synthesis

metric	value
setSize	23
pMANOVA	7.15e-05
p.adjustMANOVA	0.00191
s.dist	0.526
s.rna	0.456
s.meth	-0.262
p.rna	0.000155
p.meth	0.0294

Top 20 genes

Gene	rna	meth
UBE2L6	5721	-4598
UBA7	5122	-4999
RPA2	3762	-6294
POLD2	3426	-6387
PCNA	5031	-3646
POLE	4905	-2814
POLD1	1787	-6671
TRIM25	5484	-2055
RFC5	1809	-5508
USP43	2743	-3250
RFC3	1846	-3141
RFC2	3304	-1485
POLI	2207	-1590
REV1	5353	-564
RPA1	507	-1296
POLE4	233	-1428

Click HERE to show all gene set members

All member genes

	rna	meth
PCNA	5031	-3646
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
POLE	4905	-2814
POLE2	1497	1286
POLE3	4098	2302
POLE4	233	-1428
POLI	2207	-1590
POLK	3786	127
REV1	5353	-564
RFC1	-669	-520
RFC2	3304	-1485
RFC3	1846	-3141
RFC4	665	859
RFC5	1809	-5508
RPA1	507	-1296
RPA2	3762	-6294
TRIM25	5484	-2055
UBA7	5122	-4999
UBE2L6	5721	-4598
USP10	-3053	-6425
USP43	2743	-3250

---

---

Regulation of IFNA signaling

Regulation of IFNA signaling

metric	value
setSize	12
pMANOVA	0.00756
p.adjustMANOVA	0.0565
s.dist	0.521
s.rna	0.485
s.meth	-0.19
p.rna	0.00364
p.meth	0.254

Top 20 genes

Gene	rna	meth
PTPN6	5613.0	-6292.0
TYK2	4837.0	-4799.0
SOCS3	3782.0	-5000.0
USP18	5822.5	-3137.5
STAT1	5541.0	-1367.0
STAT2	5617.0	-554.0
PTPN1	1274.0	-1549.0
IFNAR2	244.0	-3762.0

Click HERE to show all gene set members

All member genes

	rna	meth
IFNAR1	4438.0	651.0
IFNAR2	244.0	-3762.0
JAK1	-2473.0	1184.0
PTPN1	1274.0	-1549.0
PTPN11	-4701.0	-1813.0
PTPN6	5613.0	-6292.0
SOCS1	4792.0	1777.0
SOCS3	3782.0	-5000.0
STAT1	5541.0	-1367.0
STAT2	5617.0	-554.0
TYK2	4837.0	-4799.0
USP18	5822.5	-3137.5

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	37
pMANOVA	3.07e-07
p.adjustMANOVA	3.21e-05
s.dist	0.521
s.rna	0.517
s.meth	0.0575
p.rna	5.2e-08
p.meth	0.545

Top 20 genes

Gene	rna	meth
RPS15A	5268	4133
RPS27L	4975	3865
RPL36A	4562	3358
RPS4X	4607	3294
RPL22L1	4911	2808
RPS24	4827	2701
RPS5	3705	2654
RPL30	4338	1921
RPS9	5029	1478
RPS23	2500	2927
RPS6	2334	2042
RPL31	2917	1164
RPL5	1979	1062
RPL3	4796	344
RPL37A	2758	563

Click HERE to show all gene set members

All member genes

	rna	meth
DNAJC3	-1302	-147
FAU	3553	-1986
GRSF1	-1775	71
RPL10	4592	-4690
RPL11	5333	-4485
RPL14	1821	-2318
RPL15	5231	-1145
RPL22	1872	-5539
RPL22L1	4911	2808
RPL26	1504	-4189
RPL28	724	-325
RPL3	4796	344
RPL30	4338	1921
RPL31	2917	1164
RPL32	3931	-1134
RPL34	2949	-1477
RPL36A	4562	3358
RPL37	3526	-3491
RPL37A	2758	563
RPL38	4188	-63
RPL3L	-1486	-5367
RPL5	1979	1062
RPL7	2763	-867
RPL8	2671	-5143
RPS14	1683	-3702
RPS15	2889	-2037
RPS15A	5268	4133
RPS19	4035	-2018
RPS23	2500	2927
RPS24	4827	2701
RPS26	1602	-2722
RPS27	4237	-3983
RPS27L	4975	3865
RPS4X	4607	3294
RPS5	3705	2654
RPS6	2334	2042
RPS9	5029	1478

---

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

metric	value
setSize	11
pMANOVA	0.0117
p.adjustMANOVA	0.0744
s.dist	0.52
s.rna	0.451
s.meth	0.259
p.rna	0.00968
p.meth	0.137

Top 20 genes

Gene	rna	meth
WEE1	5758	3090
CHEK1	4028	4346
YWHAZ	2176	4454
YWHAQ	4866	1387
YWHAH	2151	2593
YWHAB	3446	1534
YWHAE	1140	629

Click HERE to show all gene set members

All member genes

	rna	meth
CCNB1	5105	-2235
CDK1	4013	-3107
CHEK1	4028	4346
SFN	1298	-3495
WEE1	5758	3090
YWHAB	3446	1534
YWHAE	1140	629
YWHAG	-4299	-2889
YWHAH	2151	2593
YWHAQ	4866	1387
YWHAZ	2176	4454

---

---

FRS-mediated FGFR4 signaling

FRS-mediated FGFR4 signaling

metric	value
setSize	12
pMANOVA	0.00784
p.adjustMANOVA	0.0576
s.dist	0.519
s.rna	-0.426
s.meth	0.296
p.rna	0.0107
p.meth	0.0755

Top 20 genes

Gene	rna	meth
FGF9	-4244	3949
GRB2	-5470	1760
FGF18	-3203	1227
FRS2	-4033	581
FGF16	-148	1425

Click HERE to show all gene set members

All member genes

	rna	meth
FGF1	-4273	-1733
FGF16	-148	1425
FGF18	-3203	1227
FGF2	-4806	-2322
FGF9	-4244	3949
FRS2	-4033	581
GRB2	-5470	1760
HRAS	287	161
KRAS	1494	3596
NRAS	3683	3968
PTPN11	-4701	-1813
SOS1	-3743	-1297

---

---

Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis

metric	value
setSize	10
pMANOVA	0.0197
p.adjustMANOVA	0.104
s.dist	0.512
s.rna	0.292
s.meth	0.421
p.rna	0.109
p.meth	0.0213

Top 20 genes

Gene	rna	meth
RAD21	4704	3985
KIF23	3583	2824
SMC1A	5436	1731
STAG2	3741	2246
STAG1	1014	4028
NIPBL	434	3469
PDS5B	365	2730
KIF20A	3007	117

Click HERE to show all gene set members

All member genes

	rna	meth
KIF20A	3007	117
KIF23	3583	2824
NIPBL	434	3469
PDS5A	-5415	-1709
PDS5B	365	2730
RAD21	4704	3985
SMC1A	5436	1731
SMC3	866	-4225
STAG1	1014	4028
STAG2	3741	2246

---

---

Telomere C-strand synthesis initiation

Telomere C-strand synthesis initiation

metric	value
setSize	10
pMANOVA	0.0198
p.adjustMANOVA	0.104
s.dist	0.511
s.rna	0.462
s.meth	-0.219
p.rna	0.0114
p.meth	0.231

Top 20 genes

Gene	rna	meth
TINF2	5212	-3958
PRIM1	3555	-5621
TERF2	2852	-5885
CTC1	2518	-5310
TEN1	2492	-4558
POLA2	1693	-4205

Click HERE to show all gene set members

All member genes

	rna	meth
CTC1	2518	-5310
POLA1	5459	3646
POLA2	1693	-4205
POT1	1342	1620
PRIM1	3555	-5621
PRIM2	-2297	-36
TEN1	2492	-4558
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958

---

---

FCGR activation

FCGR activation

metric	value
setSize	16
pMANOVA	0.00205
p.adjustMANOVA	0.0258
s.dist	0.508
s.rna	0.508
s.meth	-0.021
p.rna	0.00044
p.meth	0.885

Top 20 genes

Gene	rna	meth
FGR	4773.0	-4918.0
FCGR2A	3928.5	-5706.5
HCK	5648.0	-2695.0
FCGR3A	4491.5	-2823.5
FCGR1A	5563.5	-1489.5
SRC	836.0	-5412.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5
CD247	271.0	-4228.0

Click HERE to show all gene set members

All member genes

	rna	meth
CD247	271.0	-4228.0
FCGR1A	5563.5	-1489.5
FCGR2A	3928.5	-5706.5
FCGR3A	4491.5	-2823.5
FGR	4773.0	-4918.0
FYN	2006.0	741.0
HCK	5648.0	-2695.0
IGHG1	4362.5	-489.5
IGHG2	4362.5	-489.5
IGHG3	4362.5	-489.5
IGHG4	4362.5	-489.5
IGKC	2844.0	3129.0
LYN	5142.0	4488.0
SRC	836.0	-5412.0
SYK	-4491.0	-166.0
YES1	31.0	3995.0

---

---

Activation of AMPK downstream of NMDARs

Activation of AMPK downstream of NMDARs

metric	value
setSize	10
pMANOVA	0.0229
p.adjustMANOVA	0.114
s.dist	0.502
s.rna	-0.432
s.meth	-0.256
p.rna	0.018
p.meth	0.161

Top 20 genes

Gene	rna	meth
PRKAB1	-4503	-5865
PRKAG2	-4747	-5187
PRKAG3	-4155	-5154
PRKAB2	-5221	-2924
MAPT	-5261	-1657
PRKAG1	-459	-2438

Click HERE to show all gene set members

All member genes

	rna	meth
CALM1	3036	2188
CAMKK2	2311	-5160
MAPT	-5261	-1657
PRKAA1	-61	1650
PRKAA2	-5613	123
PRKAB1	-4503	-5865
PRKAB2	-5221	-2924
PRKAG1	-459	-2438
PRKAG2	-4747	-5187
PRKAG3	-4155	-5154

---

---

Attenuation phase

Attenuation phase

metric	value
setSize	17
pMANOVA	0.00184
p.adjustMANOVA	0.0239
s.dist	0.497
s.rna	-0.497
s.meth	0.021
p.rna	0.000392
p.meth	0.881

Top 20 genes

Gene	rna	meth
HSPA1A	-5536.5	2028.5
HSPA1B	-5536.5	2028.5
COL4A6	-2343.0	4237.0
SERPINH1	-4358.0	1896.0
HSPA8	-3766.0	1540.0
EP300	-3931.0	1420.0
DNAJB6	-3589.0	1200.0

Click HERE to show all gene set members

All member genes

	rna	meth
COL4A6	-2343.0	4237.0
CREBBP	644.0	895.0
CRYBA4	-3346.0	-6091.0
DNAJB1	-3932.0	-5156.0
DNAJB6	-3589.0	1200.0
EP300	-3931.0	1420.0
FKBP4	-5216.0	-2250.0
HSBP1	-2813.0	-4293.0
HSP90AA1	-3976.0	-4716.0
HSP90AB1	-4547.0	-4818.0
HSPA1A	-5536.5	2028.5
HSPA1B	-5536.5	2028.5
HSPA8	-3766.0	1540.0
HSPH1	-4329.0	-1922.0
PTGES3	2504.0	-354.0
SERPINH1	-4358.0	1896.0
TNFRSF21	5722.0	424.0

---

---

Polymerase switching on the C-strand of the telomere

Polymerase switching on the C-strand of the telomere

metric	value
setSize	21
pMANOVA	0.000524
p.adjustMANOVA	0.00982
s.dist	0.49
s.rna	0.394
s.meth	-0.29
p.rna	0.00176
p.meth	0.0214

Top 20 genes

Gene	rna	meth
POLD2	3426	-6387
TINF2	5212	-3958
PRIM1	3555	-5621
PCNA	5031	-3646
TERF2	2852	-5885
CHTF18	2064	-6691
CTC1	2518	-5310
POLD1	1787	-6671
TEN1	2492	-4558
RFC5	1809	-5508
POLA2	1693	-4205
RFC3	1846	-3141
RFC2	3304	-1485

Click HERE to show all gene set members

All member genes

	rna	meth
CHTF18	2064	-6691
CTC1	2518	-5310
DSCC1	-345	-1132
PCNA	5031	-3646
POLA1	5459	3646
POLA2	1693	-4205
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
POT1	1342	1620
PRIM1	3555	-5621
PRIM2	-2297	-36
RFC1	-669	-520
RFC2	3304	-1485
RFC3	1846	-3141
RFC4	665	859
RFC5	1809	-5508
TEN1	2492	-4558
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958

---

---

Cleavage of the damaged pyrimidine

Cleavage of the damaged pyrimidine

metric	value
setSize	13
pMANOVA	0.00991
p.adjustMANOVA	0.0669
s.dist	0.486
s.rna	0.431
s.meth	-0.226
p.rna	0.00719
p.meth	0.159

Top 20 genes

Gene	rna	meth
TINF2	5212	-3958
TERF2	2852	-5885
NEIL2	3474	-3784
SMUG1	2445	-4605
H2AFX	2318	-4117
TDG	1699	-4885
NEIL1	1411	-3907
OGG1	3842	-1242

Click HERE to show all gene set members

All member genes

	rna	meth
H2AFX	2318	-4117
MBD4	3034	933
NEIL1	1411	-3907
NEIL2	3474	-3784
NEIL3	2579	2662
OGG1	3842	-1242
POT1	1342	1620
SMUG1	2445	-4605
TDG	1699	-4885
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958
UNG	-1483	-4342

---

---

Depyrimidination

Depyrimidination

metric	value
setSize	13
pMANOVA	0.00991
p.adjustMANOVA	0.0669
s.dist	0.486
s.rna	0.431
s.meth	-0.226
p.rna	0.00719
p.meth	0.159

Top 20 genes

Gene	rna	meth
TINF2	5212	-3958
TERF2	2852	-5885
NEIL2	3474	-3784
SMUG1	2445	-4605
H2AFX	2318	-4117
TDG	1699	-4885
NEIL1	1411	-3907
OGG1	3842	-1242

Click HERE to show all gene set members

All member genes

	rna	meth
H2AFX	2318	-4117
MBD4	3034	933
NEIL1	1411	-3907
NEIL2	3474	-3784
NEIL3	2579	2662
OGG1	3842	-1242
POT1	1342	1620
SMUG1	2445	-4605
TDG	1699	-4885
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958
UNG	-1483	-4342

---

---

Recognition and association of DNA glycosylase with site containing an affected pyrimidine

Recognition and association of DNA glycosylase with site containing an affected pyrimidine

metric	value
setSize	13
pMANOVA	0.00991
p.adjustMANOVA	0.0669
s.dist	0.486
s.rna	0.431
s.meth	-0.226
p.rna	0.00719
p.meth	0.159

Top 20 genes

Gene	rna	meth
TINF2	5212	-3958
TERF2	2852	-5885
NEIL2	3474	-3784
SMUG1	2445	-4605
H2AFX	2318	-4117
TDG	1699	-4885
NEIL1	1411	-3907
OGG1	3842	-1242

Click HERE to show all gene set members

All member genes

	rna	meth
H2AFX	2318	-4117
MBD4	3034	933
NEIL1	1411	-3907
NEIL2	3474	-3784
NEIL3	2579	2662
OGG1	3842	-1242
POT1	1342	1620
SMUG1	2445	-4605
TDG	1699	-4885
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958
UNG	-1483	-4342

---

---

Lagging Strand Synthesis

Lagging Strand Synthesis

metric	value
setSize	17
pMANOVA	0.00254
p.adjustMANOVA	0.029
s.dist	0.484
s.rna	0.403
s.meth	-0.268
p.rna	0.00402
p.meth	0.0561

Top 20 genes

Gene	rna	meth
RPA2	3762	-6294
POLD2	3426	-6387
PRIM1	3555	-5621
DNA2	2854	-6487
PCNA	5031	-3646
POLD1	1787	-6671
RFC5	1809	-5508
POLA2	1693	-4205
RFC3	1846	-3141
RFC2	3304	-1485
RPA1	507	-1296

Click HERE to show all gene set members

All member genes

	rna	meth
DNA2	2854	-6487
LIG1	5261	3019
PCNA	5031	-3646
POLA1	5459	3646
POLA2	1693	-4205
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
PRIM1	3555	-5621
PRIM2	-2297	-36
RFC1	-669	-520
RFC2	3304	-1485
RFC3	1846	-3141
RFC4	665	859
RFC5	1809	-5508
RPA1	507	-1296
RPA2	3762	-6294

---

---

Processive synthesis on the C-strand of the telomere

Processive synthesis on the C-strand of the telomere

metric	value
setSize	14
pMANOVA	0.00755
p.adjustMANOVA	0.0565
s.dist	0.482
s.rna	0.45
s.meth	-0.173
p.rna	0.00354
p.meth	0.263

Top 20 genes

Gene	rna	meth
RPA2	3762	-6294
POLD2	3426	-6387
TINF2	5212	-3958
DNA2	2854	-6487
PCNA	5031	-3646
TERF2	2852	-5885
POLD1	1787	-6671
RPA1	507	-1296

Click HERE to show all gene set members

All member genes

	rna	meth
BLM	-2002	2597
DNA2	2854	-6487
LIG1	5261	3019
PCNA	5031	-3646
POLD1	1787	-6671
POLD2	3426	-6387
POLD3	3134	1127
POT1	1342	1620
RPA1	507	-1296
RPA2	3762	-6294
TERF1	4833	2074
TERF2	2852	-5885
TINF2	5212	-3958
WRN	-258	2822

---

---

ATF6 (ATF6-alpha) activates chaperones

ATF6 (ATF6-alpha) activates chaperones

metric	value
setSize	10
pMANOVA	0.0306
p.adjustMANOVA	0.136
s.dist	0.482
s.rna	-0.208
s.meth	0.434
p.rna	0.254
p.meth	0.0174

Top 20 genes

Gene	rna	meth
HSPA5	-5640	4042
ATF6	-5681	3064
HSP90B1	-4854	3033

Click HERE to show all gene set members

All member genes

	rna	meth
ATF4	4324	3096
ATF6	-5681	3064
HSP90B1	-4854	3033
HSPA5	-5640	4042
MBTPS1	-1984	-321
MBTPS2	1591	3100
NFYA	3096	1215
NFYB	284	-3282
NFYC	454	3913
XBP1	-3175	-1855

---

---

GRB2 events in EGFR signaling

GRB2 events in EGFR signaling

metric	value
setSize	10
pMANOVA	0.0322
p.adjustMANOVA	0.14
s.dist	0.478
s.rna	-0.211
s.meth	0.43
p.rna	0.249
p.meth	0.0187

Top 20 genes

Gene	rna	meth
BTC	-4078	2572
GRB2	-5470	1760
EGF	-5657	1417

Click HERE to show all gene set members

All member genes

	rna	meth
BTC	-4078	2572
EGF	-5657	1417
EGFR	1623	3911
GRB2	-5470	1760
HBEGF	-3511	-1453
HRAS	287	161
KRAS	1494	3596
NRAS	3683	3968
SOS1	-3743	-1297
TGFA	3664	1085

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	40
pMANOVA	1.13e-06
p.adjustMANOVA	9.49e-05
s.dist	0.478
s.rna	0.477
s.meth	0.0403
p.rna	1.84e-07
p.meth	0.659

Top 20 genes

Gene	rna	meth
RPS15A	5268	4133
RPS27L	4975	3865
RPL36A	4562	3358
RPS4X	4607	3294
RPL22L1	4911	2808
RPS24	4827	2701
RPS5	3705	2654
RPL30	4338	1921
RPS9	5029	1478
RPS23	2500	2927
RPS6	2334	2042
RPL31	2917	1164
RPL5	1979	1062
RPL3	4796	344
RPL37A	2758	563

Click HERE to show all gene set members

All member genes

	rna	meth
EEF1A1	5603	-2195
EEF1A2	-5599	2201
EEF1D	-1927	-3659
EEF1G	-1503	-1941
EEF2	71	-327
FAU	3553	-1986
RPL10	4592	-4690
RPL11	5333	-4485
RPL14	1821	-2318
RPL15	5231	-1145
RPL22	1872	-5539
RPL22L1	4911	2808
RPL26	1504	-4189
RPL28	724	-325
RPL3	4796	344
RPL30	4338	1921
RPL31	2917	1164
RPL32	3931	-1134
RPL34	2949	-1477
RPL36A	4562	3358
RPL37	3526	-3491
RPL37A	2758	563
RPL38	4188	-63
RPL3L	-1486	-5367
RPL5	1979	1062
RPL7	2763	-867
RPL8	2671	-5143
RPS14	1683	-3702
RPS15	2889	-2037
RPS15A	5268	4133
RPS19	4035	-2018
RPS23	2500	2927
RPS24	4827	2701
RPS26	1602	-2722
RPS27	4237	-3983
RPS27L	4975	3865
RPS4X	4607	3294
RPS5	3705	2654
RPS6	2334	2042
RPS9	5029	1478

---

---

Signaling by BMP

Signaling by BMP

metric	value
setSize	20
pMANOVA	0.00105
p.adjustMANOVA	0.0164
s.dist	0.478
s.rna	-0.346
s.meth	0.33
p.rna	0.00744
p.meth	0.0106

Top 20 genes

Gene	rna	meth
ACVR2A	-4325	4326
BMPR1B	-3996	4021
BMPR2	-3789	3964
ZFYVE16	-3744	3350
SMURF2	-4432	2238
SMAD6	-3961	2446
BMP2	-4193	2235
CHRDL1	-1892	2124
BMPR1A	-784	1997
SKI	-416	1739
SMAD4	-1378	498

Click HERE to show all gene set members

All member genes

	rna	meth
ACVR2A	-4325	4326
ACVR2B	-4836	-1430
ACVRL1	-654	-5658
BMP2	-4193	2235
BMPR1A	-784	1997
BMPR1B	-3996	4021
BMPR2	-3789	3964
CHRDL1	-1892	2124
FSTL1	4943	449
SKI	-416	1739
SMAD1	1712	2175
SMAD4	-1378	498
SMAD5	803	2486
SMAD6	-3961	2446
SMAD7	3599	305
SMAD9	-4427	-4
SMURF1	-4944	-3217
SMURF2	-4432	2238
UBE2D1	-2504	-4281
ZFYVE16	-3744	3350

---

---

Antimicrobial peptides

Antimicrobial peptides

metric	value
setSize	11
pMANOVA	0.0238
p.adjustMANOVA	0.117
s.dist	0.476
s.rna	0.453
s.meth	-0.144
p.rna	0.00922
p.meth	0.408

Top 20 genes

Gene	rna	meth
SLC11A1	4281	-6510
CD4	4661	-5138
LYZ	5846	-3752
LCN2	3660	-3881
TLR1	5257	-1304
TLR2	5336	-696

Click HERE to show all gene set members

All member genes

	rna	meth
ATOX1	-734	485
ATP7A	4674	2676
CCR2	5868	4821
CD4	4661	-5138
CLU	-4829	-4748
DEFB136	-4150	-1602
LCN2	3660	-3881
LYZ	5846	-3752
SLC11A1	4281	-6510
TLR1	5257	-1304
TLR2	5336	-696

---

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

metric	value
setSize	26
pMANOVA	0.000166
p.adjustMANOVA	0.00386
s.dist	0.473
s.rna	0.473
s.meth	-0.0135
p.rna	3.04e-05
p.meth	0.906

Top 20 genes

Gene	rna	meth
CDT1	5256	-5611
RPA2	3762	-6294
MCM10	3961	-5565
PRIM1	3555	-5621
CDC6	3242	-5746
MCM3	4996	-2841
POLE	4905	-2814
POLA2	1693	-4205
MCM2	5312	-1197
MCM6	5516	-812
DBF4	3221	-1105
ORC5	3012	-345
CDC7	1278	-525
RPA1	507	-1296
ORC2	2059	-295
POLE4	233	-1428

Click HERE to show all gene set members

All member genes

	rna	meth
CDC6	3242	-5746
CDC7	1278	-525
CDK2	4723	1014
CDT1	5256	-5611
DBF4	3221	-1105
GMNN	-1710	1033
MCM10	3961	-5565
MCM2	5312	-1197
MCM3	4996	-2841
MCM4	5790	632
MCM5	5726	1567
MCM6	5516	-812
ORC2	2059	-295
ORC3	603	2871
ORC4	-2979	4835
ORC5	3012	-345
POLA1	5459	3646
POLA2	1693	-4205
POLE	4905	-2814
POLE2	1497	1286
POLE3	4098	2302
POLE4	233	-1428
PRIM1	3555	-5621
PRIM2	-2297	-36
RPA1	507	-1296
RPA2	3762	-6294

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	40
pMANOVA	1.82e-06
p.adjustMANOVA	0.000121
s.dist	0.47
s.rna	0.463
s.meth	0.0786
p.rna	3.97e-07
p.meth	0.39

Top 20 genes

Gene	rna	meth
RPS15A	5268	4133
RPS27L	4975	3865
RPL36A	4562	3358
RPS4X	4607	3294
RPL22L1	4911	2808
RPS24	4827	2701
RPS5	3705	2654
RPL30	4338	1921
RPS9	5029	1478
RPS23	2500	2927
RPS6	2334	2042
RPL31	2917	1164
RPL5	1979	1062
RPL3	4796	344
RPL37A	2758	563
GSPT2	47	2980

Click HERE to show all gene set members

All member genes

	rna	meth
APEH	-4397	-5348
ETF1	-1895	3682
FAU	3553	-1986
GSPT1	-3202	2711
GSPT2	47	2980
N6AMT1	3009	-993
RPL10	4592	-4690
RPL11	5333	-4485
RPL14	1821	-2318
RPL15	5231	-1145
RPL22	1872	-5539
RPL22L1	4911	2808
RPL26	1504	-4189
RPL28	724	-325
RPL3	4796	344
RPL30	4338	1921
RPL31	2917	1164
RPL32	3931	-1134
RPL34	2949	-1477
RPL36A	4562	3358
RPL37	3526	-3491
RPL37A	2758	563
RPL38	4188	-63
RPL3L	-1486	-5367
RPL5	1979	1062
RPL7	2763	-867
RPL8	2671	-5143
RPS14	1683	-3702
RPS15	2889	-2037
RPS15A	5268	4133
RPS19	4035	-2018
RPS23	2500	2927
RPS24	4827	2701
RPS26	1602	-2722
RPS27	4237	-3983
RPS27L	4975	3865
RPS4X	4607	3294
RPS5	3705	2654
RPS6	2334	2042
RPS9	5029	1478

---

---

Negative regulation of FGFR2 signaling

Negative regulation of FGFR2 signaling

metric	value
setSize	21
pMANOVA	0.00112
p.adjustMANOVA	0.0169
s.dist	0.464
s.rna	-0.388
s.meth	0.256
p.rna	0.0021
p.meth	0.0427

Top 20 genes

Gene	rna	meth
FGF9	-4244	3949
SPRY2	-3169	4248
BRAF	-2593	4561
GRB2	-5470	1760
FGF10	-2329	4120
MAPK1	-1821	4547
CBL	-3940	2098
PPP2R1A	-3542	1902
FGF18	-3203	1227
FRS2	-4033	581
FGF7	-2014	1061
FGF16	-148	1425

Click HERE to show all gene set members

All member genes

	rna	meth
BRAF	-2593	4561
CBL	-3940	2098
FGF1	-4273	-1733
FGF10	-2329	4120
FGF16	-148	1425
FGF18	-3203	1227
FGF2	-4806	-2322
FGF7	-2014	1061
FGF9	-4244	3949
FGFR2	-4480	-2755
FRS2	-4033	581
GRB2	-5470	1760
MAPK1	-1821	4547
MAPK3	1352	-3347
MKNK1	4208	-1912
PPP2CA	-307	-1775
PPP2CB	2347	1181
PPP2R1A	-3542	1902
PTPN11	-4701	-1813
SPRY2	-3169	4248
SRC	836	-5412

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0   GGally_2.0.0    ggplot2_3.3.2   reshape2_1.4.4 
##  [5] beeswarm_0.2.3  gplots_3.0.3    gtools_3.8.2    tibble_3.0.1   
##  [9] dplyr_1.0.0     echarts4r_0.3.2 mitch_1.0.6    
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.4.6       assertthat_0.2.1   rprojroot_1.3-2    digest_0.6.25     
##  [5] mime_0.9           R6_2.4.1           plyr_1.8.6         backports_1.1.8   
##  [9] evaluate_0.14      highr_0.8          pillar_1.4.4       rlang_0.4.6       
## [13] gdata_2.18.0       rmarkdown_2.3      desc_1.2.0         labeling_0.3      
## [17] stringr_1.4.0      htmlwidgets_1.5.1  munsell_0.5.0      shiny_1.5.0       
## [21] compiler_4.0.2     httpuv_1.5.4       xfun_0.15          pkgconfig_2.0.3   
## [25] htmltools_0.5.0    tidyselect_1.1.0   gridExtra_2.3      reshape_0.8.8     
## [29] crayon_1.3.4       withr_2.2.0        later_1.1.0.1      MASS_7.3-51.6     
## [33] bitops_1.0-6       grid_4.0.2         jsonlite_1.7.0     xtable_1.8-4      
## [37] gtable_0.3.0       lifecycle_0.2.0    magrittr_1.5       scales_1.1.1      
## [41] KernSmooth_2.23-17 stringi_1.4.6      farver_2.0.3       promises_1.1.1    
## [45] testthat_2.3.2     ellipsis_0.3.1     generics_0.0.2     vctrs_0.3.1       
## [49] pbmcapply_1.5.0    RColorBrewer_1.1-2 tools_4.0.2        glue_1.4.1        
## [53] purrr_0.3.4        parallel_4.0.2     fastmap_1.0.1      yaml_2.2.1        
## [57] colorspace_1.4-1   caTools_1.18.0     knitr_1.29

END of report