Mitch Report

date generated: 2020-07-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                 rna       meth
## A2M      1.45975674 -1.4404703
## A3GALT2  0.08222001  2.2664941
## A4GALT   1.70760621  0.8781088
## AAAS    -0.83461264 -0.5067923
## AACS    -2.73557983  0.2764117
## AAED1    0.02403748 -0.6411103

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	10887
duplicated_genes_present	0
num_profile_genes_in_sets	6214
num_profile_genes_not_in_sets	4673
profile_pearson_correl	-0.00332
profile_spearman_correl	0.01513

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1167
num_genesets_included	1233

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 141

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.rna	s.meth	p.rna	p.meth
Classical antibody-mediated complement activation	10	1.44e-06	1.11e-04	0.942	0.86400	-0.3750	2.25e-06	0.039900
FCGR activation	15	3.17e-05	1.35e-03	0.675	0.62600	-0.2530	2.71e-05	0.089400
Creation of C4 and C2 activators	14	7.72e-05	2.51e-03	0.669	0.64300	-0.1850	3.13e-05	0.230000
Initial triggering of complement	20	2.62e-06	1.80e-04	0.653	0.63800	-0.1390	7.95e-07	0.281000
Digestion	12	5.74e-04	1.04e-02	0.643	-0.63600	0.0950	1.38e-04	0.569000
Na+/Cl- dependent neurotransmitter transporters	11	1.37e-03	1.95e-02	0.630	-0.61700	0.1290	3.95e-04	0.460000
Digestion and absorption	13	7.45e-04	1.26e-02	0.606	-0.59300	0.1270	2.16e-04	0.428000
Cholesterol biosynthesis	16	3.56e-04	7.58e-03	0.576	-0.57500	-0.0364	6.87e-05	0.801000
Signal regulatory protein family interactions	11	3.99e-03	3.84e-02	0.574	0.42700	-0.3840	1.41e-02	0.027500
GABA synthesis, release, reuptake and degradation	11	7.32e-03	5.90e-02	0.545	-0.54300	0.0490	1.82e-03	0.778000
Regulation of IFNA signaling	10	1.31e-02	8.73e-02	0.541	0.45500	0.2930	1.26e-02	0.109000
eNOS activation	10	1.20e-02	8.24e-02	0.541	0.16100	-0.5160	3.78e-01	0.004710
SRP-dependent cotranslational protein targeting to membrane	42	2.00e-08	2.24e-06	0.533	0.51700	0.1310	6.94e-09	0.143000
Regulation of Complement cascade	30	2.80e-06	1.82e-04	0.531	0.49000	-0.2030	3.40e-06	0.054100
Citric acid cycle (TCA cycle)	13	4.29e-03	4.00e-02	0.531	-0.51900	-0.1120	1.20e-03	0.486000
Metabolism of nitric oxide: NOS3 activation and regulation	14	2.61e-03	3.15e-02	0.530	0.16900	-0.5020	2.72e-01	0.001140
Retrograde neurotrophin signalling	12	6.51e-03	5.38e-02	0.526	0.21400	-0.4810	2.00e-01	0.003940
HDMs demethylate histones	15	2.19e-03	2.79e-02	0.521	-0.52100	0.0261	4.79e-04	0.861000
HIV elongation arrest and recovery	15	3.51e-03	3.49e-02	0.505	-0.37400	-0.3400	1.22e-02	0.022600
Pausing and recovery of HIV elongation	15	3.51e-03	3.49e-02	0.505	-0.37400	-0.3400	1.22e-02	0.022600
Pausing and recovery of Tat-mediated HIV elongation	15	3.51e-03	3.49e-02	0.505	-0.37400	-0.3400	1.22e-02	0.022600
Tat-mediated HIV elongation arrest and recovery	15	3.51e-03	3.49e-02	0.505	-0.37400	-0.3400	1.22e-02	0.022600
Regulation of FZD by ubiquitination	11	1.45e-02	9.48e-02	0.504	-0.24200	0.4420	1.64e-01	0.011200
NS1 Mediated Effects on Host Pathways	25	8.97e-05	2.84e-03	0.501	-0.47700	-0.1520	3.61e-05	0.188000
Peptide chain elongation	27	4.43e-05	1.66e-03	0.500	0.46700	0.1810	2.71e-05	0.104000
Viral mRNA Translation	27	5.58e-05	1.96e-03	0.494	0.47800	0.1230	1.69e-05	0.269000
Activation of Matrix Metalloproteinases	18	1.31e-03	1.92e-02	0.494	0.47200	-0.1460	5.29e-04	0.284000
Downregulation of SMAD2/3:SMAD4 transcriptional activity	14	5.90e-03	5.12e-02	0.493	-0.47300	0.1370	2.18e-03	0.374000
Activation of gene expression by SREBF (SREBP)	35	4.11e-06	2.42e-04	0.488	-0.47500	-0.1140	1.18e-06	0.243000
Interferon gamma signaling	53	5.09e-09	7.84e-07	0.488	0.44700	-0.1950	1.78e-08	0.014100
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	19	1.25e-03	1.85e-02	0.488	-0.20900	-0.4410	1.15e-01	0.000888
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	14	6.54e-03	5.38e-02	0.487	-0.45900	0.1630	2.94e-03	0.290000
Interleukin-35 Signalling	11	2.39e-02	1.26e-01	0.478	0.17400	0.4460	3.17e-01	0.010500
Pyruvate metabolism and Citric Acid (TCA) cycle	35	7.08e-06	3.80e-04	0.478	-0.45500	-0.1460	3.20e-06	0.136000
Antimicrobial peptides	21	7.61e-04	1.27e-02	0.477	0.46900	-0.0843	1.99e-04	0.504000
Common Pathway of Fibrin Clot Formation	12	1.79e-02	1.05e-01	0.476	0.39000	0.2740	1.94e-02	0.101000
Transport of Ribonucleoproteins into the Host Nucleus	22	6.37e-04	1.14e-02	0.474	-0.46000	-0.1140	1.87e-04	0.355000
Processing of Intronless Pre-mRNAs	11	2.63e-02	1.30e-01	0.469	-0.46700	0.0474	7.39e-03	0.786000
Selenocysteine synthesis	29	9.24e-05	2.85e-03	0.464	0.44900	0.1190	2.90e-05	0.267000
Transcriptional regulation by small RNAs	29	1.03e-04	3.11e-03	0.461	-0.45400	-0.0781	2.31e-05	0.467000
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	13	1.72e-02	1.04e-01	0.460	-0.22500	-0.4010	1.60e-01	0.012400
Viral Messenger RNA Synthesis	25	4.15e-04	8.33e-03	0.458	-0.43700	-0.1390	1.59e-04	0.231000
Interferon alpha/beta signaling	37	9.90e-06	5.09e-04	0.457	0.45300	0.0591	1.85e-06	0.534000
Biosynthesis of specialized proresolving mediators (SPMs)	11	3.50e-02	1.56e-01	0.450	0.44400	-0.0723	1.08e-02	0.678000
Deposition of new CENPA-containing nucleosomes at the centromere	16	8.35e-03	6.32e-02	0.450	-0.24600	-0.3760	8.81e-02	0.009160
Nucleosome assembly	16	8.35e-03	6.32e-02	0.450	-0.24600	-0.3760	8.81e-02	0.009160
TNFR1-induced proapoptotic signaling	12	2.64e-02	1.30e-01	0.450	0.00414	-0.4500	9.80e-01	0.007020
Transport of Mature mRNAs Derived from Intronless Transcripts	29	1.64e-04	4.51e-03	0.449	-0.43900	-0.0982	4.38e-05	0.360000
Eukaryotic Translation Termination	29	1.74e-04	4.66e-03	0.448	0.44200	0.0681	3.76e-05	0.526000
Export of Viral Ribonucleoproteins from Nucleus	23	1.15e-03	1.75e-02	0.444	-0.44200	-0.0462	2.47e-04	0.701000

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.rna	s.meth	p.rna	p.meth
Classical antibody-mediated complement activation	10	1.44e-06	1.11e-04	0.94200	0.864000	-0.375000	2.25e-06	0.039900
FCGR activation	15	3.17e-05	1.35e-03	0.67500	0.626000	-0.253000	2.71e-05	0.089400
Creation of C4 and C2 activators	14	7.72e-05	2.51e-03	0.66900	0.643000	-0.185000	3.13e-05	0.230000
Initial triggering of complement	20	2.62e-06	1.80e-04	0.65300	0.638000	-0.139000	7.95e-07	0.281000
Digestion	12	5.74e-04	1.04e-02	0.64300	-0.636000	0.095000	1.38e-04	0.569000
Na+/Cl- dependent neurotransmitter transporters	11	1.37e-03	1.95e-02	0.63000	-0.617000	0.129000	3.95e-04	0.460000
Digestion and absorption	13	7.45e-04	1.26e-02	0.60600	-0.593000	0.127000	2.16e-04	0.428000
Cholesterol biosynthesis	16	3.56e-04	7.58e-03	0.57600	-0.575000	-0.036400	6.87e-05	0.801000
Signal regulatory protein family interactions	11	3.99e-03	3.84e-02	0.57400	0.427000	-0.384000	1.41e-02	0.027500
GABA synthesis, release, reuptake and degradation	11	7.32e-03	5.90e-02	0.54500	-0.543000	0.049000	1.82e-03	0.778000
Regulation of IFNA signaling	10	1.31e-02	8.73e-02	0.54100	0.455000	0.293000	1.26e-02	0.109000
eNOS activation	10	1.20e-02	8.24e-02	0.54100	0.161000	-0.516000	3.78e-01	0.004710
SRP-dependent cotranslational protein targeting to membrane	42	2.00e-08	2.24e-06	0.53300	0.517000	0.131000	6.94e-09	0.143000
Regulation of Complement cascade	30	2.80e-06	1.82e-04	0.53100	0.490000	-0.203000	3.40e-06	0.054100
Citric acid cycle (TCA cycle)	13	4.29e-03	4.00e-02	0.53100	-0.519000	-0.112000	1.20e-03	0.486000
Metabolism of nitric oxide: NOS3 activation and regulation	14	2.61e-03	3.15e-02	0.53000	0.169000	-0.502000	2.72e-01	0.001140
Retrograde neurotrophin signalling	12	6.51e-03	5.38e-02	0.52600	0.214000	-0.481000	2.00e-01	0.003940
HDMs demethylate histones	15	2.19e-03	2.79e-02	0.52100	-0.521000	0.026100	4.79e-04	0.861000
HIV elongation arrest and recovery	15	3.51e-03	3.49e-02	0.50500	-0.374000	-0.340000	1.22e-02	0.022600
Pausing and recovery of HIV elongation	15	3.51e-03	3.49e-02	0.50500	-0.374000	-0.340000	1.22e-02	0.022600
Pausing and recovery of Tat-mediated HIV elongation	15	3.51e-03	3.49e-02	0.50500	-0.374000	-0.340000	1.22e-02	0.022600
Tat-mediated HIV elongation arrest and recovery	15	3.51e-03	3.49e-02	0.50500	-0.374000	-0.340000	1.22e-02	0.022600
Regulation of FZD by ubiquitination	11	1.45e-02	9.48e-02	0.50400	-0.242000	0.442000	1.64e-01	0.011200
NS1 Mediated Effects on Host Pathways	25	8.97e-05	2.84e-03	0.50100	-0.477000	-0.152000	3.61e-05	0.188000
Peptide chain elongation	27	4.43e-05	1.66e-03	0.50000	0.467000	0.181000	2.71e-05	0.104000
Viral mRNA Translation	27	5.58e-05	1.96e-03	0.49400	0.478000	0.123000	1.69e-05	0.269000
Activation of Matrix Metalloproteinases	18	1.31e-03	1.92e-02	0.49400	0.472000	-0.146000	5.29e-04	0.284000
Downregulation of SMAD2/3:SMAD4 transcriptional activity	14	5.90e-03	5.12e-02	0.49300	-0.473000	0.137000	2.18e-03	0.374000
Activation of gene expression by SREBF (SREBP)	35	4.11e-06	2.42e-04	0.48800	-0.475000	-0.114000	1.18e-06	0.243000
Interferon gamma signaling	53	5.09e-09	7.84e-07	0.48800	0.447000	-0.195000	1.78e-08	0.014100
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	19	1.25e-03	1.85e-02	0.48800	-0.209000	-0.441000	1.15e-01	0.000888
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	14	6.54e-03	5.38e-02	0.48700	-0.459000	0.163000	2.94e-03	0.290000
Interleukin-35 Signalling	11	2.39e-02	1.26e-01	0.47800	0.174000	0.446000	3.17e-01	0.010500
Pyruvate metabolism and Citric Acid (TCA) cycle	35	7.08e-06	3.80e-04	0.47800	-0.455000	-0.146000	3.20e-06	0.136000
Antimicrobial peptides	21	7.61e-04	1.27e-02	0.47700	0.469000	-0.084300	1.99e-04	0.504000
Common Pathway of Fibrin Clot Formation	12	1.79e-02	1.05e-01	0.47600	0.390000	0.274000	1.94e-02	0.101000
Transport of Ribonucleoproteins into the Host Nucleus	22	6.37e-04	1.14e-02	0.47400	-0.460000	-0.114000	1.87e-04	0.355000
Processing of Intronless Pre-mRNAs	11	2.63e-02	1.30e-01	0.46900	-0.467000	0.047400	7.39e-03	0.786000
Selenocysteine synthesis	29	9.24e-05	2.85e-03	0.46400	0.449000	0.119000	2.90e-05	0.267000
Transcriptional regulation by small RNAs	29	1.03e-04	3.11e-03	0.46100	-0.454000	-0.078100	2.31e-05	0.467000
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	13	1.72e-02	1.04e-01	0.46000	-0.225000	-0.401000	1.60e-01	0.012400
Viral Messenger RNA Synthesis	25	4.15e-04	8.33e-03	0.45800	-0.437000	-0.139000	1.59e-04	0.231000
Interferon alpha/beta signaling	37	9.90e-06	5.09e-04	0.45700	0.453000	0.059100	1.85e-06	0.534000
Biosynthesis of specialized proresolving mediators (SPMs)	11	3.50e-02	1.56e-01	0.45000	0.444000	-0.072300	1.08e-02	0.678000
Deposition of new CENPA-containing nucleosomes at the centromere	16	8.35e-03	6.32e-02	0.45000	-0.246000	-0.376000	8.81e-02	0.009160
Nucleosome assembly	16	8.35e-03	6.32e-02	0.45000	-0.246000	-0.376000	8.81e-02	0.009160
TNFR1-induced proapoptotic signaling	12	2.64e-02	1.30e-01	0.45000	0.004140	-0.450000	9.80e-01	0.007020
Transport of Mature mRNAs Derived from Intronless Transcripts	29	1.64e-04	4.51e-03	0.44900	-0.439000	-0.098200	4.38e-05	0.360000
Eukaryotic Translation Termination	29	1.74e-04	4.66e-03	0.44800	0.442000	0.068100	3.76e-05	0.526000
Export of Viral Ribonucleoproteins from Nucleus	23	1.15e-03	1.75e-02	0.44400	-0.442000	-0.046200	2.47e-04	0.701000
Regulation of TP53 Activity through Acetylation	22	1.82e-03	2.41e-02	0.44100	-0.331000	-0.291000	7.27e-03	0.018000
Resolution of D-Loop Structures	23	1.41e-03	1.97e-02	0.44000	-0.250000	-0.362000	3.81e-02	0.002680
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	20	3.14e-03	3.49e-02	0.43900	-0.438000	-0.035200	7.03e-04	0.786000
Regulation of Glucokinase by Glucokinase Regulatory Protein	20	3.14e-03	3.49e-02	0.43900	-0.438000	-0.035200	7.03e-04	0.786000
Transport of Mature mRNA Derived from an Intronless Transcript	28	3.51e-04	7.58e-03	0.43700	-0.430000	-0.076600	8.27e-05	0.483000
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	20	3.27e-03	3.49e-02	0.43500	-0.420000	0.115000	1.15e-03	0.375000
Interactions of Rev with host cellular proteins	25	8.80e-04	1.43e-02	0.43500	-0.424000	-0.097200	2.44e-04	0.400000
Complement cascade	37	2.59e-05	1.14e-03	0.43500	0.413000	-0.135000	1.38e-05	0.154000
Deadenylation of mRNA	16	1.09e-02	7.62e-02	0.43200	-0.418000	0.109000	3.77e-03	0.450000
ER Quality Control Compartment (ERQC)	11	4.65e-02	1.89e-01	0.43200	-0.034400	-0.431000	8.43e-01	0.013400
Pyruvate metabolism	21	3.05e-03	3.48e-02	0.43100	-0.412000	-0.127000	1.08e-03	0.316000
Activation of the pre-replicative complex	23	1.76e-03	2.38e-02	0.43100	-0.416000	-0.112000	5.56e-04	0.353000
Transport of the SLBP Dependant Mature mRNA	24	1.34e-03	1.95e-02	0.43100	-0.413000	-0.122000	4.60e-04	0.303000
Abortive elongation of HIV-1 transcript in the absence of Tat	12	3.73e-02	1.62e-01	0.43000	-0.376000	-0.210000	2.42e-02	0.209000
mRNA Capping	16	1.28e-02	8.61e-02	0.43000	-0.269000	-0.335000	6.27e-02	0.020300
TP53 Regulates Transcription of Death Receptors and Ligands	10	6.51e-02	2.25e-01	0.42900	-0.185000	-0.387000	3.10e-01	0.034000
Budding and maturation of HIV virion	15	1.51e-02	9.73e-02	0.42900	0.277000	-0.327000	6.29e-02	0.028600
Formation of a pool of free 40S subunits	33	1.42e-04	3.97e-03	0.42500	0.415000	0.091300	3.72e-05	0.364000
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	12	4.07e-02	1.71e-01	0.42500	0.361000	0.223000	3.03e-02	0.181000
RNA Pol II CTD phosphorylation and interaction with CE	15	1.91e-02	1.10e-01	0.42300	-0.235000	-0.351000	1.16e-01	0.018500
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	15	1.91e-02	1.10e-01	0.42300	-0.235000	-0.351000	1.16e-01	0.018500
TNFs bind their physiological receptors	19	6.35e-03	5.34e-02	0.42100	0.419000	-0.041900	1.58e-03	0.752000
FOXO-mediated transcription of cell death genes	13	3.03e-02	1.42e-01	0.42000	-0.294000	0.301000	6.66e-02	0.060500
Nuclear import of Rev protein	23	2.41e-03	2.95e-02	0.42000	-0.410000	-0.088500	6.64e-04	0.463000
Rev-mediated nuclear export of HIV RNA	24	1.84e-03	2.41e-02	0.42000	-0.415000	-0.061600	4.34e-04	0.602000
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	7.15e-02	2.37e-01	0.41900	0.053200	-0.415000	7.71e-01	0.023000
Formation of the beta-catenin:TCF transactivating complex	29	4.53e-04	8.73e-03	0.41900	-0.376000	0.184000	4.57e-04	0.087100
Eukaryotic Translation Elongation	30	4.19e-04	8.33e-03	0.41800	0.385000	0.165000	2.67e-04	0.119000
FGFR2 alternative splicing	13	3.42e-02	1.55e-01	0.41800	-0.386000	-0.162000	1.60e-02	0.313000
Resolution of D-loop Structures through Holliday Junction Intermediates	22	3.40e-03	3.49e-02	0.41800	-0.232000	-0.348000	6.02e-02	0.004700
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	29	5.63e-04	1.04e-02	0.41700	0.389000	0.152000	2.93e-04	0.158000
NEP/NS2 Interacts with the Cellular Export Machinery	22	3.29e-03	3.49e-02	0.41700	-0.417000	-0.006840	7.20e-04	0.956000
Heme degradation	11	6.05e-02	2.17e-01	0.41400	0.397000	0.118000	2.27e-02	0.497000
Transport of the SLBP independent Mature mRNA	23	2.92e-03	3.40e-02	0.41300	-0.402000	-0.096200	8.58e-04	0.425000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	11	6.44e-02	2.24e-01	0.41100	0.335000	0.238000	5.45e-02	0.172000
PKMTs methylate histone lysines	32	3.23e-04	7.38e-03	0.41000	-0.410000	-0.018400	6.14e-05	0.857000
Other interleukin signaling	16	1.93e-02	1.10e-01	0.40800	0.145000	0.381000	3.16e-01	0.008300
Vpr-mediated nuclear import of PICs	23	3.36e-03	3.49e-02	0.40800	-0.400000	-0.077500	8.92e-04	0.520000
Gluconeogenesis	21	5.53e-03	4.87e-02	0.40600	-0.404000	0.038000	1.35e-03	0.763000
Thromboxane signalling through TP receptor	14	3.30e-02	1.51e-01	0.40500	0.392000	0.101000	1.11e-02	0.512000
Surfactant metabolism	13	4.20e-02	1.75e-01	0.40100	0.208000	-0.343000	1.95e-01	0.032500
Diseases of carbohydrate metabolism	22	5.71e-03	4.99e-02	0.39800	0.373000	0.140000	2.50e-03	0.256000
Glutamate Neurotransmitter Release Cycle	15	2.85e-02	1.37e-01	0.39500	-0.261000	0.297000	8.07e-02	0.046600
Receptor-type tyrosine-protein phosphatases	10	9.55e-02	2.84e-01	0.39300	0.339000	-0.200000	6.37e-02	0.274000
SUMOylation of SUMOylation proteins	22	6.38e-03	5.34e-02	0.39200	-0.390000	-0.045600	1.56e-03	0.712000
GTP hydrolysis and joining of the 60S ribosomal subunit	38	1.79e-04	4.70e-03	0.39100	0.375000	0.113000	6.49e-05	0.230000
Glucuronidation	10	1.02e-01	2.93e-01	0.39100	0.387000	0.060000	3.43e-02	0.743000
ADP signalling through P2Y purinoceptor 1	17	2.17e-02	1.17e-01	0.39000	0.361000	0.147000	9.95e-03	0.294000
Prostacyclin signalling through prostacyclin receptor	11	8.08e-02	2.57e-01	0.39000	0.386000	-0.053000	2.66e-02	0.761000
L13a-mediated translational silencing of Ceruloplasmin expression	37	2.40e-04	5.87e-03	0.38900	0.377000	0.096000	7.16e-05	0.313000
Interactions of Vpr with host cellular proteins	25	3.62e-03	3.57e-02	0.38900	-0.382000	-0.072400	9.55e-04	0.531000
Regulation of TP53 Activity through Association with Co-factors	10	1.04e-01	2.95e-01	0.38800	0.015800	-0.388000	9.31e-01	0.033800
FOXO-mediated transcription of cell cycle genes	13	5.16e-02	2.02e-01	0.38800	-0.346000	0.176000	3.09e-02	0.273000
Attenuation phase	15	3.68e-02	1.62e-01	0.38400	-0.381000	-0.046100	1.06e-02	0.757000
Glutathione synthesis and recycling	10	1.12e-01	3.02e-01	0.38200	0.025600	-0.381000	8.88e-01	0.037000
Misspliced GSK3beta mutants stabilize beta-catenin	13	5.80e-02	2.10e-01	0.38200	-0.380000	0.035300	1.77e-02	0.826000
S33 mutants of beta-catenin aren't phosphorylated	13	5.80e-02	2.10e-01	0.38200	-0.380000	0.035300	1.77e-02	0.826000
S37 mutants of beta-catenin aren't phosphorylated	13	5.80e-02	2.10e-01	0.38200	-0.380000	0.035300	1.77e-02	0.826000
S45 mutants of beta-catenin aren't phosphorylated	13	5.80e-02	2.10e-01	0.38200	-0.380000	0.035300	1.77e-02	0.826000
T41 mutants of beta-catenin aren't phosphorylated	13	5.80e-02	2.10e-01	0.38200	-0.380000	0.035300	1.77e-02	0.826000
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	13	5.80e-02	2.10e-01	0.38200	-0.380000	0.035300	1.77e-02	0.826000
Diseases associated with glycosylation precursor biosynthesis	15	3.82e-02	1.65e-01	0.38200	0.381000	0.026700	1.07e-02	0.858000
Regulation of cholesterol biosynthesis by SREBP (SREBF)	45	6.34e-05	2.17e-03	0.38000	-0.369000	-0.091500	1.85e-05	0.289000
Fertilization	10	1.16e-01	3.10e-01	0.37600	0.279000	-0.252000	1.27e-01	0.167000
Regulation of pyruvate dehydrogenase (PDH) complex	11	9.89e-02	2.87e-01	0.37500	-0.375000	-0.006250	3.15e-02	0.971000
Interleukin-10 signaling	29	2.32e-03	2.92e-02	0.37500	0.370000	0.056200	5.57e-04	0.601000
SUMOylation of ubiquitinylation proteins	25	5.35e-03	4.78e-02	0.37500	-0.371000	-0.049900	1.32e-03	0.666000
Formation of Fibrin Clot (Clotting Cascade)	23	8.41e-03	6.32e-02	0.37400	0.358000	0.109000	2.99e-03	0.365000
Postmitotic nuclear pore complex (NPC) reformation	20	1.65e-02	1.03e-01	0.37100	-0.367000	-0.057100	4.56e-03	0.659000
ROS and RNS production in phagocytes	22	1.01e-02	7.25e-02	0.37100	0.245000	-0.279000	4.71e-02	0.023700
Translesion Synthesis by POLH	10	1.25e-01	3.23e-01	0.37000	-0.188000	0.319000	3.04e-01	0.080700
Signaling by Leptin	10	1.25e-01	3.24e-01	0.37000	-0.211000	0.303000	2.47e-01	0.097000
Interleukin-7 signaling	14	5.62e-02	2.09e-01	0.36900	-0.362000	0.074400	1.91e-02	0.630000
Regulation of TP53 Degradation	27	4.34e-03	4.02e-02	0.36900	-0.325000	-0.175000	3.46e-03	0.116000
Regulation of HSF1-mediated heat shock response	50	4.05e-05	1.61e-03	0.36800	-0.368000	-0.005950	6.88e-06	0.942000
Triglyceride metabolism	19	2.15e-02	1.16e-01	0.36600	-0.357000	0.080700	7.06e-03	0.542000
Class I peroxisomal membrane protein import	10	1.30e-01	3.31e-01	0.36600	0.244000	-0.273000	1.81e-01	0.135000
G0 and Early G1	21	1.43e-02	9.46e-02	0.36600	-0.352000	0.098800	5.20e-03	0.433000
Cell recruitment (pro-inflammatory response)	18	2.61e-02	1.30e-01	0.36500	0.317000	-0.182000	2.00e-02	0.182000
Purinergic signaling in leishmaniasis infection	18	2.61e-02	1.30e-01	0.36500	0.317000	-0.182000	2.00e-02	0.182000
NOTCH2 intracellular domain regulates transcription	10	1.40e-01	3.39e-01	0.36500	-0.214000	-0.296000	2.42e-01	0.106000
VLDLR internalisation and degradation	10	1.34e-01	3.32e-01	0.36500	0.112000	-0.347000	5.41e-01	0.057400
Transcription of E2F targets under negative control by DREAM complex	16	3.98e-02	1.69e-01	0.36400	-0.300000	0.207000	3.81e-02	0.152000
G1/S-Specific Transcription	23	1.03e-02	7.40e-02	0.36300	-0.354000	0.080300	3.28e-03	0.505000
DNA Damage/Telomere Stress Induced Senescence	20	2.14e-02	1.16e-01	0.36100	-0.314000	-0.177000	1.50e-02	0.171000
CS/DS degradation	11	1.17e-01	3.11e-01	0.36000	0.353000	-0.069000	4.25e-02	0.692000
Condensation of Prophase Chromosomes	10	1.43e-01	3.43e-01	0.35900	-0.355000	0.056300	5.20e-02	0.758000
Metabolism of steroid hormones	22	1.49e-02	9.62e-02	0.35900	0.340000	0.115000	5.77e-03	0.352000
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	11	1.24e-01	3.23e-01	0.35900	0.296000	0.203000	8.94e-02	0.244000
CD28 dependent PI3K/Akt signaling	19	2.74e-02	1.33e-01	0.35800	-0.160000	-0.320000	2.28e-01	0.015800
Presynaptic depolarization and calcium channel opening	11	1.23e-01	3.23e-01	0.35700	-0.356000	-0.018600	4.09e-02	0.915000
Cellular response to heat stress	66	3.74e-06	2.31e-04	0.35600	-0.355000	0.024200	6.29e-07	0.735000
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	30	3.18e-03	3.49e-02	0.35600	-0.307000	0.180000	3.64e-03	0.089000
Platelet Adhesion to exposed collagen	11	1.30e-01	3.31e-01	0.35500	0.263000	0.238000	1.31e-01	0.171000
Striated Muscle Contraction	30	3.49e-03	3.49e-02	0.35400	-0.353000	0.035900	8.34e-04	0.734000
Collagen degradation	27	6.41e-03	5.34e-02	0.35400	0.350000	0.054700	1.65e-03	0.623000
Miscellaneous transport and binding events	16	5.21e-02	2.02e-01	0.35300	-0.311000	-0.167000	3.12e-02	0.247000
Downregulation of ERBB2 signaling	17	4.07e-02	1.71e-01	0.35300	0.089900	-0.342000	5.21e-01	0.014800
RORA activates gene expression	16	5.18e-02	2.02e-01	0.35300	-0.342000	-0.087800	1.80e-02	0.543000
Depolymerisation of the Nuclear Lamina	13	8.73e-02	2.69e-01	0.35100	-0.299000	0.185000	6.20e-02	0.249000
Glucagon-type ligand receptors	15	6.40e-02	2.23e-01	0.35100	0.338000	0.096500	2.36e-02	0.518000
ADP signalling through P2Y purinoceptor 12	13	9.06e-02	2.73e-01	0.35000	0.345000	-0.058900	3.12e-02	0.713000
Metabolism of Angiotensinogen to Angiotensins	11	1.30e-01	3.31e-01	0.34900	0.244000	-0.250000	1.62e-01	0.152000
TP53 Regulates Transcription of DNA Repair Genes	38	1.11e-03	1.72e-02	0.34800	-0.280000	-0.207000	2.81e-03	0.027400
Cap-dependent Translation Initiation	44	3.63e-04	7.58e-03	0.34800	0.338000	0.083800	1.06e-04	0.337000
Eukaryotic Translation Initiation	44	3.63e-04	7.58e-03	0.34800	0.338000	0.083800	1.06e-04	0.337000
AMER1 mutants destabilize the destruction complex	12	1.12e-01	3.02e-01	0.34800	-0.347000	0.033200	3.77e-02	0.842000
APC truncation mutants have impaired AXIN binding	12	1.12e-01	3.02e-01	0.34800	-0.347000	0.033200	3.77e-02	0.842000
AXIN missense mutants destabilize the destruction complex	12	1.12e-01	3.02e-01	0.34800	-0.347000	0.033200	3.77e-02	0.842000
AXIN mutants destabilize the destruction complex, activating WNT signaling	12	1.12e-01	3.02e-01	0.34800	-0.347000	0.033200	3.77e-02	0.842000
Truncations of AMER1 destabilize the destruction complex	12	1.12e-01	3.02e-01	0.34800	-0.347000	0.033200	3.77e-02	0.842000
truncated APC mutants destabilize the destruction complex	12	1.12e-01	3.02e-01	0.34800	-0.347000	0.033200	3.77e-02	0.842000
NOTCH3 Activation and Transmission of Signal to the Nucleus	16	5.60e-02	2.09e-01	0.34800	-0.057400	-0.343000	6.91e-01	0.017600
Formation of the ternary complex, and subsequently, the 43S complex	17	4.84e-02	1.94e-01	0.34600	0.338000	0.071500	1.57e-02	0.610000
EGFR downregulation	19	3.70e-02	1.62e-01	0.34300	-0.172000	-0.296000	1.95e-01	0.025400
Regulation of TP53 Expression and Degradation	28	7.82e-03	6.11e-02	0.34300	-0.284000	-0.192000	9.34e-03	0.079300
Amino acid transport across the plasma membrane	26	1.08e-02	7.60e-02	0.34300	-0.328000	-0.099200	3.82e-03	0.382000
Triglyceride catabolism	13	1.00e-01	2.88e-01	0.34200	-0.326000	0.103000	4.16e-02	0.521000
PKA activation	15	7.30e-02	2.40e-01	0.34100	0.013500	0.341000	9.28e-01	0.022200
Repression of WNT target genes	11	1.44e-01	3.44e-01	0.34000	-0.234000	0.247000	1.80e-01	0.155000
Signaling by WNT in cancer	26	1.07e-02	7.55e-02	0.33900	-0.277000	0.196000	1.46e-02	0.084100
SUMOylation of DNA replication proteins	32	4.18e-03	3.96e-02	0.33900	-0.336000	-0.040700	9.96e-04	0.691000
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.51e-01	3.51e-01	0.33900	-0.338000	0.017500	5.22e-02	0.920000
Regulation of TNFR1 signaling	24	1.71e-02	1.04e-01	0.33800	-0.125000	-0.314000	2.88e-01	0.007770
Glucose metabolism	63	2.29e-05	1.05e-03	0.33700	-0.336000	-0.027700	3.99e-06	0.704000
PINK1-PRKN Mediated Mitophagy	13	1.10e-01	3.02e-01	0.33700	-0.057600	-0.332000	7.19e-01	0.038000
Formation of HIV elongation complex in the absence of HIV Tat	23	2.14e-02	1.16e-01	0.33700	-0.250000	-0.226000	3.82e-02	0.061200
Formation of HIV-1 elongation complex containing HIV-1 Tat	23	2.14e-02	1.16e-01	0.33700	-0.250000	-0.226000	3.82e-02	0.061200
HIV Transcription Elongation	23	2.14e-02	1.16e-01	0.33700	-0.250000	-0.226000	3.82e-02	0.061200
Tat-mediated elongation of the HIV-1 transcript	23	2.14e-02	1.16e-01	0.33700	-0.250000	-0.226000	3.82e-02	0.061200
Late endosomal microautophagy	17	5.42e-02	2.06e-01	0.33600	0.287000	-0.175000	4.05e-02	0.212000
Nucleotide-like (purinergic) receptors	10	1.90e-01	4.08e-01	0.33500	0.308000	0.132000	9.18e-02	0.471000
Signal amplification	22	2.54e-02	1.29e-01	0.33500	0.331000	0.045600	7.14e-03	0.712000
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	1.39e-01	3.37e-01	0.33400	-0.242000	-0.230000	1.46e-01	0.168000
Kinesins	29	8.47e-03	6.33e-02	0.33400	-0.177000	-0.283000	1.00e-01	0.008310
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	61	4.26e-05	1.64e-03	0.33300	0.330000	0.045800	8.48e-06	0.537000
Cytosolic sulfonation of small molecules	14	9.80e-02	2.87e-01	0.33300	0.332000	0.019900	3.13e-02	0.898000
E2F mediated regulation of DNA replication	18	5.25e-02	2.02e-01	0.33300	-0.276000	-0.186000	4.25e-02	0.172000
Regulation of IFNG signaling	10	1.92e-01	4.10e-01	0.33100	0.321000	-0.078700	7.85e-02	0.667000
Homologous DNA Pairing and Strand Exchange	28	1.09e-02	7.62e-02	0.33000	-0.159000	-0.290000	1.46e-01	0.007980
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	2.37e-02	1.26e-01	0.33000	-0.328000	-0.036700	6.47e-03	0.761000
Endogenous sterols	18	5.55e-02	2.08e-01	0.33000	0.217000	0.249000	1.11e-01	0.067900
Glycolysis	51	2.58e-04	6.01e-03	0.33000	-0.328000	-0.031500	5.08e-05	0.698000
RNA polymerase II transcribes snRNA genes	47	5.39e-04	1.01e-02	0.33000	-0.266000	-0.195000	1.64e-03	0.020700
Removal of the Flap Intermediate	11	1.69e-01	3.79e-01	0.32900	-0.319000	-0.083100	6.72e-02	0.633000
Regulation of beta-cell development	19	4.79e-02	1.93e-01	0.32900	-0.298000	-0.138000	2.44e-02	0.297000
HSF1 activation	18	5.35e-02	2.05e-01	0.32800	-0.310000	0.107000	2.28e-02	0.432000
Intrinsic Pathway of Fibrin Clot Formation	14	1.07e-01	2.97e-01	0.32800	0.315000	0.092000	4.14e-02	0.551000
Smooth Muscle Contraction	26	1.57e-02	1.00e-01	0.32800	0.317000	0.082100	5.11e-03	0.469000
Selenoamino acid metabolism	39	2.01e-03	2.58e-02	0.32800	0.316000	0.086000	6.42e-04	0.353000
Response of EIF2AK4 (GCN2) to amino acid deficiency	32	6.32e-03	5.34e-02	0.32700	0.302000	0.126000	3.14e-03	0.219000
G beta:gamma signalling through PLC beta	12	1.46e-01	3.46e-01	0.32600	0.324000	-0.038700	5.21e-02	0.817000
Translesion synthesis by REV1	10	2.03e-01	4.18e-01	0.32400	-0.294000	0.137000	1.07e-01	0.453000
Circadian Clock	53	2.30e-04	5.79e-03	0.32300	-0.297000	0.129000	1.89e-04	0.105000
Positive epigenetic regulation of rRNA expression	32	7.27e-03	5.90e-02	0.32300	-0.260000	-0.192000	1.11e-02	0.059800
Gap junction trafficking	13	1.27e-01	3.27e-01	0.32300	0.208000	-0.247000	1.93e-01	0.124000
Interleukin-6 family signaling	17	7.33e-02	2.40e-01	0.32300	0.237000	0.220000	9.15e-02	0.117000
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	10	2.05e-01	4.22e-01	0.32300	-0.195000	0.257000	2.86e-01	0.159000
SUMOylation of transcription cofactors	32	7.11e-03	5.80e-02	0.32200	-0.317000	-0.059600	1.94e-03	0.560000
Scavenging by Class A Receptors	10	2.07e-01	4.25e-01	0.32200	0.284000	-0.151000	1.19e-01	0.408000
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	30	9.71e-03	7.04e-02	0.32100	-0.321000	-0.004610	2.33e-03	0.965000
B-WICH complex positively regulates rRNA expression	21	3.97e-02	1.69e-01	0.32100	-0.315000	-0.062400	1.25e-02	0.621000
Processive synthesis on the lagging strand	12	1.60e-01	3.65e-01	0.31900	-0.319000	0.002730	5.55e-02	0.987000
Oncogene Induced Senescence	24	2.58e-02	1.30e-01	0.31900	-0.319000	-0.010000	6.85e-03	0.932000
VEGFR2 mediated vascular permeability	24	2.62e-02	1.30e-01	0.31900	-0.031100	-0.317000	7.92e-01	0.007160
Rap1 signalling	14	1.16e-01	3.10e-01	0.31900	-0.133000	0.290000	3.90e-01	0.060600
Interleukin-20 family signaling	12	1.65e-01	3.73e-01	0.31900	0.172000	0.268000	3.02e-01	0.108000
Dissolution of Fibrin Clot	10	2.23e-01	4.36e-01	0.31700	0.316000	0.017300	8.32e-02	0.924000
HDR through Single Strand Annealing (SSA)	26	2.15e-02	1.16e-01	0.31600	-0.157000	-0.274000	1.65e-01	0.015500
Interleukin-12 family signaling	40	2.76e-03	3.31e-02	0.31600	0.237000	0.209000	9.48e-03	0.022300
Glycosphingolipid metabolism	27	1.75e-02	1.04e-01	0.31400	0.264000	-0.170000	1.75e-02	0.126000
Amine ligand-binding receptors	14	1.25e-01	3.23e-01	0.31300	-0.144000	0.278000	3.52e-01	0.071700
Antigen processing-Cross presentation	65	7.43e-05	2.48e-03	0.31100	0.284000	-0.128000	7.71e-05	0.075200
TP53 Regulates Transcription of Cell Cycle Genes	38	4.07e-03	3.89e-02	0.31100	-0.311000	0.015500	9.30e-04	0.869000
Role of phospholipids in phagocytosis	25	2.60e-02	1.30e-01	0.31100	0.098400	-0.295000	3.95e-01	0.010700
G beta:gamma signalling through CDC42	11	2.01e-01	4.17e-01	0.31100	0.293000	-0.102000	9.20e-02	0.558000
Processive synthesis on the C-strand of the telomere	13	1.50e-01	3.50e-01	0.31000	-0.261000	0.168000	1.04e-01	0.295000
Class B/2 (Secretin family receptors)	45	1.70e-03	2.33e-02	0.30900	0.289000	0.111000	8.12e-04	0.197000
Hyaluronan metabolism	11	2.11e-01	4.25e-01	0.30900	0.296000	0.087300	8.92e-02	0.616000
SUMO E3 ligases SUMOylate target proteins	117	7.29e-08	6.91e-06	0.30900	-0.298000	-0.079900	2.72e-08	0.137000
Signaling by cytosolic FGFR1 fusion mutants	16	9.94e-02	2.88e-01	0.30800	-0.173000	0.255000	2.31e-01	0.077500
Detoxification of Reactive Oxygen Species	19	6.59e-02	2.26e-01	0.30800	0.298000	-0.076000	2.44e-02	0.566000
HDR through Homologous Recombination (HRR)	42	2.92e-03	3.40e-02	0.30700	-0.213000	-0.222000	1.71e-02	0.013100
Signal transduction by L1	15	1.24e-01	3.23e-01	0.30700	0.157000	0.263000	2.93e-01	0.077400
SUMOylation	122	4.80e-08	4.93e-06	0.30600	-0.293000	-0.087600	2.33e-08	0.095800
Beta-catenin phosphorylation cascade	15	1.19e-01	3.15e-01	0.30600	-0.276000	0.131000	6.42e-02	0.378000
Signaling by FGFR2 in disease	21	5.56e-02	2.08e-01	0.30400	-0.298000	-0.059900	1.81e-02	0.635000
Nuclear Pore Complex (NPC) Disassembly	25	3.12e-02	1.45e-01	0.30400	-0.303000	0.025500	8.79e-03	0.825000
Gene Silencing by RNA	44	2.37e-03	2.95e-02	0.30400	-0.303000	-0.019800	5.14e-04	0.820000
G-protein activation	15	1.26e-01	3.26e-01	0.30300	0.303000	0.000711	4.20e-02	0.996000
Signaling by Erythropoietin	19	7.06e-02	2.35e-01	0.30300	-0.265000	0.147000	4.55e-02	0.267000
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	67	1.14e-04	3.26e-03	0.30300	-0.284000	-0.104000	5.79e-05	0.141000
Amplification of signal from the kinetochores	67	1.14e-04	3.26e-03	0.30300	-0.284000	-0.104000	5.79e-05	0.141000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	2.59e-01	4.71e-01	0.30200	0.162000	0.255000	3.75e-01	0.163000
PKA activation in glucagon signalling	14	1.47e-01	3.46e-01	0.30200	-0.033000	0.300000	8.31e-01	0.052200
ERBB2 Activates PTK6 Signaling	10	2.55e-01	4.69e-01	0.30100	0.048600	-0.297000	7.90e-01	0.104000
Presynaptic function of Kainate receptors	13	1.69e-01	3.79e-01	0.30100	0.285000	-0.094700	7.51e-02	0.555000
Constitutive Signaling by EGFRvIII	12	2.01e-01	4.17e-01	0.30000	-0.278000	-0.114000	9.58e-02	0.496000
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	12	2.01e-01	4.17e-01	0.30000	-0.278000	-0.114000	9.58e-02	0.496000
Signaling by EGFRvIII in Cancer	12	2.01e-01	4.17e-01	0.30000	-0.278000	-0.114000	9.58e-02	0.496000
Signaling by Ligand-Responsive EGFR Variants in Cancer	12	2.01e-01	4.17e-01	0.30000	-0.278000	-0.114000	9.58e-02	0.496000
N-Glycan antennae elongation	10	2.63e-01	4.75e-01	0.29900	0.065200	0.292000	7.21e-01	0.110000
Processing of Capped Intronless Pre-mRNA	17	1.04e-01	2.95e-01	0.29900	-0.288000	-0.081700	4.01e-02	0.560000
Activation of ATR in response to replication stress	23	4.77e-02	1.93e-01	0.29900	-0.285000	-0.089800	1.82e-02	0.456000
mRNA decay by 5' to 3' exoribonuclease	12	2.00e-01	4.17e-01	0.29800	-0.276000	0.112000	9.79e-02	0.503000
Recognition of DNA damage by PCNA-containing replication complex	17	1.08e-01	2.99e-01	0.29600	-0.296000	0.007710	3.49e-02	0.956000
Resolution of Sister Chromatid Cohesion	76	5.46e-05	1.96e-03	0.29600	-0.284000	-0.082400	1.94e-05	0.215000
Signaling by EGFR	34	1.27e-02	8.57e-02	0.29500	-0.230000	-0.185000	2.02e-02	0.062300
Telomere Extension By Telomerase	15	1.38e-01	3.36e-01	0.29500	-0.212000	0.205000	1.55e-01	0.170000
ATF4 activates genes in response to endoplasmic reticulum stress	17	1.06e-01	2.97e-01	0.29500	-0.242000	0.168000	8.40e-02	0.230000
Estrogen-dependent gene expression	65	2.43e-04	5.87e-03	0.29500	-0.267000	-0.124000	1.99e-04	0.083500
Endosomal Sorting Complex Required For Transport (ESCRT)	17	1.07e-01	2.97e-01	0.29500	0.254000	-0.150000	7.03e-02	0.285000
Signaling by FGFR3 in disease	13	1.84e-01	3.98e-01	0.29400	-0.292000	0.034500	6.82e-02	0.829000
Signaling by FGFR3 point mutants in cancer	13	1.84e-01	3.98e-01	0.29400	-0.292000	0.034500	6.82e-02	0.829000
DNA strand elongation	23	5.17e-02	2.02e-01	0.29400	-0.289000	-0.051600	1.63e-02	0.669000
Branched-chain amino acid catabolism	19	8.82e-02	2.69e-01	0.29400	-0.121000	-0.268000	3.63e-01	0.043300
Deactivation of the beta-catenin transactivating complex	27	2.98e-02	1.42e-01	0.29300	-0.262000	0.131000	1.84e-02	0.241000
Zinc transporters	11	2.44e-01	4.57e-01	0.29300	-0.017300	-0.292000	9.21e-01	0.093500
FGFR2 mutant receptor activation	13	1.93e-01	4.13e-01	0.29300	-0.194000	-0.219000	2.25e-01	0.172000
Transcriptional regulation of pluripotent stem cells	18	1.03e-01	2.93e-01	0.29300	0.222000	0.191000	1.04e-01	0.161000
Translesion synthesis by POLK	11	2.42e-01	4.55e-01	0.29200	-0.270000	0.111000	1.21e-01	0.523000
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	17	1.11e-01	3.02e-01	0.29100	-0.238000	0.168000	8.91e-02	0.231000
Disassembly of the destruction complex and recruitment of AXIN to the membrane	24	4.52e-02	1.86e-01	0.29100	-0.193000	0.218000	1.02e-01	0.064100
PKA-mediated phosphorylation of CREB	16	1.32e-01	3.31e-01	0.29100	-0.008000	0.291000	9.56e-01	0.044200
Activation of G protein gated Potassium channels	16	1.34e-01	3.32e-01	0.29000	0.284000	0.059100	4.92e-02	0.682000
G protein gated Potassium channels	16	1.34e-01	3.32e-01	0.29000	0.284000	0.059100	4.92e-02	0.682000
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	16	1.34e-01	3.32e-01	0.29000	0.284000	0.059100	4.92e-02	0.682000
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	32	1.77e-02	1.05e-01	0.29000	-0.290000	0.008730	4.55e-03	0.932000
Regulation of TP53 Activity	114	8.02e-07	6.59e-05	0.29000	-0.233000	-0.172000	1.80e-05	0.001510
Formation of RNA Pol II elongation complex	33	1.73e-02	1.04e-01	0.28900	-0.246000	-0.151000	1.46e-02	0.133000
RNA Polymerase II Transcription Elongation	33	1.73e-02	1.04e-01	0.28900	-0.246000	-0.151000	1.46e-02	0.133000
Collagen biosynthesis and modifying enzymes	46	3.46e-03	3.49e-02	0.28700	0.287000	0.009830	7.63e-04	0.908000
TRAF6 mediated NF-kB activation	18	1.10e-01	3.02e-01	0.28700	-0.054700	-0.282000	6.88e-01	0.038700
Downstream signaling of activated FGFR3	15	1.59e-01	3.65e-01	0.28600	-0.286000	-0.017000	5.54e-02	0.909000
Ribosomal scanning and start codon recognition	20	8.86e-02	2.69e-01	0.28600	0.272000	0.088300	3.54e-02	0.495000
Translation initiation complex formation	20	8.86e-02	2.69e-01	0.28600	0.272000	0.088300	3.54e-02	0.495000
Regulation of signaling by CBL	15	1.59e-01	3.64e-01	0.28500	-0.088100	0.271000	5.55e-01	0.069300
Synthesis, secretion, and deacylation of Ghrelin	10	2.96e-01	5.05e-01	0.28400	0.280000	-0.050100	1.26e-01	0.784000
Pre-NOTCH Transcription and Translation	29	3.16e-02	1.46e-01	0.28400	-0.129000	-0.253000	2.30e-01	0.018500
ER-Phagosome pathway	52	1.79e-03	2.39e-02	0.28400	0.260000	-0.114000	1.19e-03	0.157000
Insulin processing	16	1.42e-01	3.41e-01	0.28300	-0.191000	0.209000	1.85e-01	0.148000
Cross-presentation of soluble exogenous antigens (endosomes)	35	1.47e-02	9.55e-02	0.28200	0.248000	-0.135000	1.12e-02	0.169000
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	3.04e-01	5.11e-01	0.28200	0.005110	0.282000	9.78e-01	0.123000
TNFR1-induced NFkappaB signaling pathway	22	7.61e-02	2.48e-01	0.28200	-0.184000	-0.213000	1.35e-01	0.083400
Downstream signaling of activated FGFR4	15	1.68e-01	3.78e-01	0.28100	-0.279000	0.032100	6.12e-02	0.830000
Inwardly rectifying K+ channels	19	1.07e-01	2.97e-01	0.28100	0.280000	0.027800	3.50e-02	0.834000
SUMOylation of DNA damage response and repair proteins	49	3.28e-03	3.49e-02	0.28000	-0.274000	-0.059700	9.16e-04	0.471000
Presynaptic phase of homologous DNA pairing and strand exchange	25	5.46e-02	2.06e-01	0.28000	-0.118000	-0.254000	3.06e-01	0.027900
PI-3K cascade:FGFR1	11	2.72e-01	4.83e-01	0.28000	-0.272000	0.067000	1.18e-01	0.700000
Chondroitin sulfate biosynthesis	16	1.53e-01	3.56e-01	0.28000	0.280000	0.004670	5.28e-02	0.974000
Interleukin-12 signaling	32	2.50e-02	1.28e-01	0.28000	0.209000	0.185000	4.05e-02	0.069600
Carnitine metabolism	11	2.80e-01	4.91e-01	0.27900	-0.267000	-0.081700	1.25e-01	0.639000
Plasma lipoprotein clearance	25	5.29e-02	2.03e-01	0.27900	0.256000	-0.111000	2.70e-02	0.337000
N-glycan antennae elongation in the medial/trans-Golgi	16	1.57e-01	3.62e-01	0.27900	0.061200	0.272000	6.72e-01	0.059800
PERK regulates gene expression	19	1.06e-01	2.97e-01	0.27800	-0.203000	0.191000	1.26e-01	0.150000
HSF1-dependent transactivation	24	6.41e-02	2.23e-01	0.27600	-0.276000	0.013500	1.93e-02	0.909000
Cyclin A/B1/B2 associated events during G2/M transition	12	2.58e-01	4.69e-01	0.27600	-0.253000	-0.111000	1.30e-01	0.505000
Removal of the Flap Intermediate from the C-strand	12	2.53e-01	4.67e-01	0.27500	-0.255000	0.103000	1.26e-01	0.538000
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	21	9.86e-02	2.87e-01	0.27300	0.248000	0.115000	4.97e-02	0.362000
VEGFR2 mediated cell proliferation	18	1.33e-01	3.32e-01	0.27300	-0.270000	0.036600	4.71e-02	0.788000
Synthesis of PC	19	1.17e-01	3.12e-01	0.27200	-0.164000	0.218000	2.17e-01	0.101000
Leading Strand Synthesis	12	2.72e-01	4.83e-01	0.27100	-0.218000	-0.162000	1.92e-01	0.333000
Polymerase switching	12	2.72e-01	4.83e-01	0.27100	-0.218000	-0.162000	1.92e-01	0.333000
Mitophagy	17	1.55e-01	3.58e-01	0.27100	0.006160	-0.271000	9.65e-01	0.053500
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	13	2.39e-01	4.53e-01	0.27000	-0.255000	0.088000	1.11e-01	0.583000
Signaling by ERBB2 ECD mutants	13	2.47e-01	4.59e-01	0.26900	-0.265000	-0.040200	9.75e-02	0.802000
Diseases associated with N-glycosylation of proteins	14	2.25e-01	4.39e-01	0.26800	0.239000	0.121000	1.21e-01	0.432000
Regulation of TP53 Activity through Phosphorylation	62	1.38e-03	1.95e-02	0.26800	-0.244000	-0.111000	8.94e-04	0.130000
DAG and IP3 signaling	34	2.44e-02	1.27e-01	0.26800	-0.187000	0.192000	5.92e-02	0.052600
PCNA-Dependent Long Patch Base Excision Repair	15	1.95e-01	4.15e-01	0.26800	-0.239000	0.121000	1.08e-01	0.419000
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	3.11e-01	5.18e-01	0.26800	-0.137000	-0.231000	4.33e-01	0.186000
Nuclear Envelope Breakdown	38	1.65e-02	1.03e-01	0.26800	-0.261000	0.061600	5.47e-03	0.512000
Lagging Strand Synthesis	16	1.80e-01	3.93e-01	0.26800	-0.267000	-0.020900	6.47e-02	0.885000
Regulation of gene expression by Hypoxia-inducible Factor	10	3.43e-01	5.54e-01	0.26700	-0.004690	0.267000	9.80e-01	0.144000
Binding and Uptake of Ligands by Scavenger Receptors	27	5.41e-02	2.06e-01	0.26700	0.233000	-0.130000	3.60e-02	0.243000
Defective CFTR causes cystic fibrosis	37	1.86e-02	1.08e-01	0.26700	0.242000	-0.111000	1.08e-02	0.242000
ZBP1(DAI) mediated induction of type I IFNs	18	1.52e-01	3.53e-01	0.26600	-0.078800	-0.254000	5.63e-01	0.062500
FOXO-mediated transcription	49	5.49e-03	4.87e-02	0.26500	-0.252000	0.084900	2.34e-03	0.304000
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	11	3.12e-01	5.19e-01	0.26500	-0.071200	0.255000	6.83e-01	0.143000
Mitotic Spindle Checkpoint	82	2.25e-04	5.77e-03	0.26400	-0.231000	-0.128000	3.11e-04	0.045200
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	1.56e-01	3.59e-01	0.26400	-0.081600	-0.251000	5.49e-01	0.065500
RIP-mediated NFkB activation via ZBP1	15	2.12e-01	4.25e-01	0.26400	-0.079000	-0.252000	5.96e-01	0.091600
WNT ligand biogenesis and trafficking	14	2.38e-01	4.52e-01	0.26400	0.187000	0.186000	2.25e-01	0.229000
Apoptotic execution phase	35	2.74e-02	1.33e-01	0.26300	-0.248000	-0.089400	1.12e-02	0.360000
Cellular hexose transport	12	2.89e-01	4.97e-01	0.26300	0.011900	0.263000	9.43e-01	0.115000
Energy dependent regulation of mTOR by LKB1-AMPK	20	1.28e-01	3.27e-01	0.26300	-0.259000	-0.045700	4.51e-02	0.724000
Regulation of expression of SLITs and ROBOs	78	3.41e-04	7.58e-03	0.26200	0.262000	0.017600	6.58e-05	0.789000
CLEC7A (Dectin-1) induces NFAT activation	10	3.55e-01	5.63e-01	0.26200	-0.258000	0.048100	1.58e-01	0.792000
Transcription of the HIV genome	43	1.30e-02	8.73e-02	0.26200	-0.180000	-0.191000	4.17e-02	0.030800
Metabolism of non-coding RNA	34	3.04e-02	1.42e-01	0.26200	-0.261000	0.022800	8.54e-03	0.818000
snRNP Assembly	34	3.04e-02	1.42e-01	0.26200	-0.261000	0.022800	8.54e-03	0.818000
Assembly of active LPL and LIPC lipase complexes	15	2.12e-01	4.25e-01	0.26100	0.120000	-0.232000	4.22e-01	0.120000
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	3.21e-01	5.29e-01	0.26100	0.232000	-0.120000	1.83e-01	0.490000
Effects of PIP2 hydrolysis	19	1.47e-01	3.46e-01	0.26100	-0.236000	-0.112000	7.52e-02	0.400000
Synthesis of very long-chain fatty acyl-CoAs	15	2.21e-01	4.36e-01	0.26100	-0.221000	-0.139000	1.39e-01	0.350000
Synaptic adhesion-like molecules	14	2.35e-01	4.51e-01	0.26100	0.206000	-0.160000	1.83e-01	0.300000
EML4 and NUDC in mitotic spindle formation	70	8.96e-04	1.44e-02	0.26100	-0.244000	-0.090200	4.13e-04	0.193000
Mitochondrial biogenesis	60	2.42e-03	2.95e-02	0.26000	-0.256000	-0.046700	6.17e-04	0.532000
Meiotic synapsis	23	9.73e-02	2.87e-01	0.26000	-0.259000	0.016700	3.14e-02	0.889000
SUMOylation of RNA binding proteins	34	3.22e-02	1.48e-01	0.26000	-0.260000	0.005960	8.81e-03	0.952000
Calnexin/calreticulin cycle	14	2.44e-01	4.57e-01	0.26000	-0.012700	-0.259000	9.34e-01	0.093200
Formation of tubulin folding intermediates by CCT/TriC	15	2.25e-01	4.39e-01	0.25900	-0.217000	-0.142000	1.45e-01	0.341000
Nucleobase catabolism	22	1.08e-01	3.00e-01	0.25800	0.235000	-0.107000	5.63e-02	0.385000
Ubiquitin-dependent degradation of Cyclin D	34	3.35e-02	1.52e-01	0.25700	0.240000	-0.092900	1.56e-02	0.349000
Mitochondrial translation initiation	55	4.40e-03	4.02e-02	0.25700	0.257000	-0.001060	9.89e-04	0.989000
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	11	3.43e-01	5.54e-01	0.25600	-0.218000	-0.136000	2.12e-01	0.436000
Synthesis of glycosylphosphatidylinositol (GPI)	10	3.78e-01	5.78e-01	0.25600	0.113000	0.230000	5.37e-01	0.208000
Translation	148	6.22e-07	5.48e-05	0.25500	0.255000	0.010100	9.06e-08	0.833000
Cleavage of the damaged purine	10	3.71e-01	5.74e-01	0.25500	-0.123000	0.224000	5.00e-01	0.220000
Depurination	10	3.71e-01	5.74e-01	0.25500	-0.123000	0.224000	5.00e-01	0.220000
Recognition and association of DNA glycosylase with site containing an affected purine	10	3.71e-01	5.74e-01	0.25500	-0.123000	0.224000	5.00e-01	0.220000
Hedgehog ligand biogenesis	40	1.92e-02	1.10e-01	0.25500	0.210000	-0.145000	2.15e-02	0.113000
Regulation of MECP2 expression and activity	23	1.07e-01	2.97e-01	0.25400	-0.249000	0.052800	3.91e-02	0.661000
RUNX3 regulates NOTCH signaling	13	2.88e-01	4.97e-01	0.25400	-0.095400	-0.235000	5.52e-01	0.142000
DNA Double Strand Break Response	32	4.75e-02	1.93e-01	0.25400	-0.137000	-0.214000	1.81e-01	0.036100
activated TAK1 mediates p38 MAPK activation	15	2.31e-01	4.47e-01	0.25400	-0.207000	0.146000	1.65e-01	0.328000
Apoptotic cleavage of cellular proteins	29	6.41e-02	2.23e-01	0.25200	-0.248000	-0.044400	2.07e-02	0.679000
Laminin interactions	22	1.21e-01	3.18e-01	0.25200	-0.225000	0.113000	6.79e-02	0.360000
TNF signaling	31	5.59e-02	2.09e-01	0.25100	-0.138000	-0.210000	1.84e-01	0.043500
Mitotic Prometaphase	139	2.63e-06	1.80e-04	0.25100	-0.240000	-0.071000	1.06e-06	0.150000
Neutrophil degranulation	315	2.23e-13	2.75e-10	0.25100	0.242000	-0.066200	2.26e-13	0.044900
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	2.43e-01	4.57e-01	0.25000	-0.061900	0.242000	6.78e-01	0.104000
Constitutive Signaling by AKT1 E17K in Cancer	21	1.42e-01	3.41e-01	0.25000	-0.243000	-0.060400	5.44e-02	0.632000
Inhibition of DNA recombination at telomere	12	3.30e-01	5.39e-01	0.25000	-0.220000	-0.118000	1.86e-01	0.480000
SUMOylation of chromatin organization proteins	39	2.71e-02	1.33e-01	0.24900	-0.246000	-0.041200	7.91e-03	0.656000
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	44	1.75e-02	1.04e-01	0.24900	0.236000	0.081300	6.91e-03	0.351000
Nonsense-Mediated Decay (NMD)	44	1.75e-02	1.04e-01	0.24900	0.236000	0.081300	6.91e-03	0.351000
Signaling by NOTCH2	21	1.47e-01	3.46e-01	0.24900	-0.162000	-0.189000	2.00e-01	0.133000
Gap junction trafficking and regulation	15	2.45e-01	4.57e-01	0.24800	0.188000	-0.162000	2.08e-01	0.276000
Chromosome Maintenance	56	6.21e-03	5.34e-02	0.24800	-0.230000	-0.091500	2.90e-03	0.237000
FRS-mediated FGFR1 signaling	10	3.97e-01	6.00e-01	0.24800	-0.247000	0.022800	1.77e-01	0.901000
Synthesis of bile acids and bile salts	18	1.96e-01	4.17e-01	0.24800	0.187000	0.162000	1.69e-01	0.234000
Signaling by FGFR1 in disease	26	8.88e-02	2.69e-01	0.24800	-0.156000	0.193000	1.70e-01	0.089400
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	21	1.48e-01	3.47e-01	0.24700	-0.246000	-0.008160	5.07e-02	0.948000
Deadenylation-dependent mRNA decay	38	3.08e-02	1.43e-01	0.24600	-0.235000	0.073900	1.22e-02	0.431000
Synthesis of PIPs at the Golgi membrane	11	3.65e-01	5.72e-01	0.24600	-0.235000	0.073400	1.77e-01	0.673000
Lewis blood group biosynthesis	10	4.00e-01	6.01e-01	0.24600	0.227000	-0.093900	2.13e-01	0.607000
Homology Directed Repair	70	1.99e-03	2.58e-02	0.24600	-0.178000	-0.170000	1.00e-02	0.014300
Synthesis of IP2, IP, and Ins in the cytosol	12	3.41e-01	5.54e-01	0.24600	0.077500	0.233000	6.42e-01	0.162000
Downstream signal transduction	25	1.01e-01	2.91e-01	0.24600	-0.153000	0.192000	1.85e-01	0.096900
Translesion synthesis by POLI	11	3.67e-01	5.72e-01	0.24500	-0.205000	0.134000	2.39e-01	0.442000
TP53 Regulates Transcription of Cell Death Genes	30	7.04e-02	2.35e-01	0.24500	-0.148000	-0.195000	1.60e-01	0.064700
Thrombin signalling through proteinase activated receptors (PARs)	22	1.38e-01	3.37e-01	0.24500	0.245000	-0.008450	4.70e-02	0.945000
Tie2 Signaling	14	2.81e-01	4.91e-01	0.24400	-0.209000	0.126000	1.75e-01	0.413000
Late Phase of HIV Life Cycle	83	7.09e-04	1.23e-02	0.24400	-0.162000	-0.182000	1.08e-02	0.004150
Glutamate binding, activation of AMPA receptors and synaptic plasticity	23	1.32e-01	3.31e-01	0.24400	-0.236000	-0.058900	4.99e-02	0.625000
Trafficking of AMPA receptors	23	1.32e-01	3.31e-01	0.24400	-0.236000	-0.058900	4.99e-02	0.625000
WNT5A-dependent internalization of FZD4	11	3.83e-01	5.83e-01	0.24300	-0.117000	-0.213000	5.02e-01	0.222000
Formation of the Early Elongation Complex	19	1.92e-01	4.10e-01	0.24300	-0.204000	-0.132000	1.25e-01	0.319000
Formation of the HIV-1 Early Elongation Complex	19	1.92e-01	4.10e-01	0.24300	-0.204000	-0.132000	1.25e-01	0.319000
p38MAPK events	11	3.76e-01	5.75e-01	0.24300	-0.062700	0.234000	7.19e-01	0.178000
Negative regulators of DDX58/IFIH1 signaling	20	1.76e-01	3.87e-01	0.24200	-0.117000	-0.212000	3.66e-01	0.101000
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	66	3.38e-03	3.49e-02	0.24200	-0.172000	-0.171000	1.60e-02	0.016500
Pre-NOTCH Expression and Processing	42	2.63e-02	1.30e-01	0.24200	-0.105000	-0.218000	2.38e-01	0.014500
Bile acid and bile salt metabolism	20	1.76e-01	3.87e-01	0.24200	0.229000	0.079300	7.67e-02	0.539000
TRP channels	16	2.47e-01	4.59e-01	0.24100	0.241000	-0.009890	9.48e-02	0.945000
Glyoxylate metabolism and glycine degradation	21	1.61e-01	3.67e-01	0.24100	-0.241000	-0.017000	5.63e-02	0.893000
Gap-filling DNA repair synthesis and ligation in GG-NER	17	2.26e-01	4.40e-01	0.24100	-0.240000	0.028400	8.73e-02	0.839000
Heme biosynthesis	10	4.14e-01	6.10e-01	0.24100	-0.217000	0.105000	2.35e-01	0.565000
Diseases associated with the TLR signaling cascade	18	2.10e-01	4.25e-01	0.24100	-0.001830	-0.241000	9.89e-01	0.077200
Diseases of Immune System	18	2.10e-01	4.25e-01	0.24100	-0.001830	-0.241000	9.89e-01	0.077200
Integration of energy metabolism	83	7.22e-04	1.24e-02	0.24100	-0.225000	0.085000	3.99e-04	0.182000
Other semaphorin interactions	18	2.14e-01	4.28e-01	0.24100	0.117000	0.211000	3.92e-01	0.122000
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	34	5.08e-02	2.00e-01	0.24000	0.201000	-0.132000	4.27e-02	0.184000
TGF-beta receptor signaling activates SMADs	18	2.15e-01	4.29e-01	0.24000	-0.209000	-0.119000	1.25e-01	0.383000
HIV Life Cycle	91	4.51e-04	8.73e-03	0.24000	-0.167000	-0.173000	5.91e-03	0.004530
Signaling by Hippo	17	2.35e-01	4.51e-01	0.23800	0.000184	0.238000	9.99e-01	0.088900
HCMV Early Events	44	2.47e-02	1.27e-01	0.23800	-0.224000	-0.082100	1.03e-02	0.346000
Extension of Telomeres	35	4.94e-02	1.97e-01	0.23800	-0.215000	0.104000	2.81e-02	0.289000
Negative regulation of NOTCH4 signaling	35	4.96e-02	1.97e-01	0.23800	0.188000	-0.146000	5.43e-02	0.137000
Vif-mediated degradation of APOBEC3G	32	6.54e-02	2.26e-01	0.23700	0.183000	-0.151000	7.36e-02	0.141000
IL-6-type cytokine receptor ligand interactions	12	3.71e-01	5.74e-01	0.23700	0.199000	0.128000	2.33e-01	0.442000
SLC transporter disorders	64	4.66e-03	4.19e-02	0.23600	-0.228000	0.063100	1.66e-03	0.384000
Plasma lipoprotein assembly, remodeling, and clearance	48	1.74e-02	1.04e-01	0.23600	0.193000	-0.136000	2.10e-02	0.103000
HSP90 chaperone cycle for steroid hormone receptors (SHR)	28	9.78e-02	2.87e-01	0.23600	-0.235000	-0.016300	3.13e-02	0.881000
Response of Mtb to phagocytosis	17	2.40e-01	4.54e-01	0.23600	-0.223000	0.075800	1.11e-01	0.589000
DNA Double-Strand Break Repair	90	6.66e-04	1.17e-02	0.23500	-0.175000	-0.158000	4.22e-03	0.009870
Transcriptional activation of mitochondrial biogenesis	45	2.44e-02	1.27e-01	0.23500	-0.233000	-0.030200	6.78e-03	0.726000
PI-3K cascade:FGFR4	11	3.98e-01	6.00e-01	0.23500	-0.216000	0.093800	2.16e-01	0.590000
SHC1 events in ERBB2 signaling	17	2.47e-01	4.59e-01	0.23500	-0.039700	-0.232000	7.77e-01	0.098500
Gap-filling DNA repair synthesis and ligation in TC-NER	41	3.51e-02	1.56e-01	0.23400	-0.232000	-0.033600	1.03e-02	0.710000
EPHB-mediated forward signaling	24	1.39e-01	3.38e-01	0.23400	0.234000	-0.010500	4.75e-02	0.929000
Uptake and actions of bacterial toxins	26	1.21e-01	3.17e-01	0.23300	-0.233000	-0.009800	3.97e-02	0.931000
GAB1 signalosome	12	3.74e-01	5.74e-01	0.23300	0.059600	-0.225000	7.21e-01	0.177000
RAB geranylgeranylation	36	5.22e-02	2.02e-01	0.23300	0.218000	-0.082300	2.37e-02	0.393000
Mitochondrial translation termination	55	1.16e-02	7.97e-02	0.23300	0.231000	-0.030900	3.14e-03	0.692000
CASP8 activity is inhibited	10	4.43e-01	6.33e-01	0.23200	0.054900	-0.226000	7.64e-01	0.217000
Dimerization of procaspase-8	10	4.43e-01	6.33e-01	0.23200	0.054900	-0.226000	7.64e-01	0.217000
Regulation by c-FLIP	10	4.43e-01	6.33e-01	0.23200	0.054900	-0.226000	7.64e-01	0.217000
Activated NOTCH1 Transmits Signal to the Nucleus	19	2.22e-01	4.36e-01	0.23100	-0.109000	-0.204000	4.12e-01	0.123000
GRB2 events in ERBB2 signaling	11	4.14e-01	6.10e-01	0.23100	0.029500	-0.229000	8.65e-01	0.189000
Arachidonic acid metabolism	32	8.09e-02	2.57e-01	0.23100	0.207000	0.102000	4.29e-02	0.320000
p130Cas linkage to MAPK signaling for integrins	10	4.56e-01	6.44e-01	0.23000	0.200000	0.115000	2.75e-01	0.529000
Glucagon signaling in metabolic regulation	21	1.93e-01	4.13e-01	0.23000	0.132000	0.188000	2.94e-01	0.135000
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	25	1.42e-01	3.41e-01	0.23000	0.149000	0.176000	1.99e-01	0.128000
Downstream signaling of activated FGFR2	17	2.57e-01	4.69e-01	0.23000	-0.224000	0.052200	1.10e-01	0.709000
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	31	8.93e-02	2.70e-01	0.23000	-0.129000	-0.190000	2.15e-01	0.066700
Prolactin receptor signaling	10	4.52e-01	6.40e-01	0.22900	-0.047300	0.224000	7.96e-01	0.219000
Transcriptional Regulation by TP53	247	7.01e-09	9.60e-07	0.22900	-0.201000	-0.109000	5.93e-08	0.003330
Glycogen breakdown (glycogenolysis)	11	4.16e-01	6.12e-01	0.22900	-0.159000	0.164000	3.61e-01	0.345000
DDX58/IFIH1-mediated induction of interferon-alpha/beta	43	3.60e-02	1.60e-01	0.22900	-0.098900	-0.206000	2.62e-01	0.019300
Downregulation of TGF-beta receptor signaling	16	2.89e-01	4.97e-01	0.22900	-0.212000	-0.087000	1.43e-01	0.547000
Sema4D in semaphorin signaling	19	2.26e-01	4.40e-01	0.22800	0.228000	-0.006550	8.49e-02	0.961000
Growth hormone receptor signaling	18	2.51e-01	4.64e-01	0.22800	0.094400	0.207000	4.88e-01	0.128000
Chemokine receptors bind chemokines	31	8.73e-02	2.69e-01	0.22800	0.169000	-0.152000	1.03e-01	0.143000
Oxidative Stress Induced Senescence	51	2.00e-02	1.13e-01	0.22700	-0.223000	-0.044700	5.96e-03	0.581000
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	2.92e-01	5.00e-01	0.22700	-0.223000	-0.043000	1.23e-01	0.766000
Mitochondrial translation elongation	55	1.45e-02	9.48e-02	0.22700	0.227000	-0.006200	3.65e-03	0.937000
Telomere C-strand (Lagging Strand) Synthesis	25	1.44e-01	3.44e-01	0.22600	-0.214000	0.073300	6.38e-02	0.526000
Hh mutants abrogate ligand secretion	36	6.10e-02	2.18e-01	0.22600	0.187000	-0.128000	5.29e-02	0.184000
Peptide ligand-binding receptors	75	3.04e-03	3.48e-02	0.22600	0.202000	-0.102000	2.52e-03	0.128000
PI-3K cascade:FGFR3	11	4.30e-01	6.21e-01	0.22600	-0.224000	0.026900	1.98e-01	0.877000
Recruitment of NuMA to mitotic centrosomes	64	8.04e-03	6.24e-02	0.22600	-0.211000	-0.081100	3.58e-03	0.262000
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	4.02e-01	6.03e-01	0.22600	0.027500	0.224000	8.69e-01	0.179000
Epigenetic regulation of gene expression	59	1.23e-02	8.38e-02	0.22500	-0.196000	-0.110000	9.20e-03	0.145000
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	32	8.78e-02	2.69e-01	0.22400	0.191000	-0.117000	6.17e-02	0.253000
p53-Independent DNA Damage Response	32	8.78e-02	2.69e-01	0.22400	0.191000	-0.117000	6.17e-02	0.253000
p53-Independent G1/S DNA damage checkpoint	32	8.78e-02	2.69e-01	0.22400	0.191000	-0.117000	6.17e-02	0.253000
Negative regulation of MET activity	13	3.82e-01	5.82e-01	0.22400	-0.151000	-0.165000	3.45e-01	0.303000
G beta:gamma signalling through PI3Kgamma	15	3.23e-01	5.31e-01	0.22400	0.220000	-0.038700	1.40e-01	0.795000
IRS-mediated signalling	31	9.82e-02	2.87e-01	0.22400	-0.224000	0.005200	3.13e-02	0.960000
Activation of kainate receptors upon glutamate binding	21	2.10e-01	4.25e-01	0.22300	0.223000	0.015900	7.75e-02	0.900000
Signaling by EGFR in Cancer	14	3.59e-01	5.67e-01	0.22300	-0.152000	-0.162000	3.24e-01	0.293000
Centrosome maturation	65	8.59e-03	6.34e-02	0.22300	-0.205000	-0.086700	4.28e-03	0.227000
Recruitment of mitotic centrosome proteins and complexes	65	8.59e-03	6.34e-02	0.22300	-0.205000	-0.086700	4.28e-03	0.227000
Mitochondrial protein import	44	3.90e-02	1.67e-01	0.22200	-0.019600	-0.222000	8.22e-01	0.011100
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	17	2.82e-01	4.91e-01	0.22200	-0.110000	0.193000	4.35e-01	0.169000
Neurodegenerative Diseases	17	2.82e-01	4.91e-01	0.22200	-0.110000	0.193000	4.35e-01	0.169000
Chromatin modifying enzymes	150	1.87e-05	8.89e-04	0.22200	-0.221000	-0.008910	3.09e-06	0.851000
Chromatin organization	150	1.87e-05	8.89e-04	0.22200	-0.221000	-0.008910	3.09e-06	0.851000
APC-Cdc20 mediated degradation of Nek2A	19	2.51e-01	4.65e-01	0.22100	-0.065900	-0.211000	6.19e-01	0.111000
ESR-mediated signaling	116	2.48e-04	5.89e-03	0.22100	-0.174000	-0.137000	1.25e-03	0.011200
Regulation of PLK1 Activity at G2/M Transition	62	1.06e-02	7.55e-02	0.22100	-0.218000	0.034600	2.98e-03	0.638000
Autodegradation of Cdh1 by Cdh1:APC/C	44	3.86e-02	1.67e-01	0.22100	0.137000	-0.173000	1.16e-01	0.047200
TNFR2 non-canonical NF-kB pathway	66	7.72e-03	6.11e-02	0.22100	0.190000	-0.113000	7.75e-03	0.113000
Formation of the cornified envelope	20	2.36e-01	4.51e-01	0.22100	-0.079200	-0.206000	5.40e-01	0.111000
EPH-ephrin mediated repulsion of cells	37	6.72e-02	2.28e-01	0.22000	0.218000	-0.034700	2.21e-02	0.715000
TRAF6 mediated IRF7 activation	14	3.66e-01	5.72e-01	0.22000	-0.112000	-0.190000	4.70e-01	0.219000
Retrograde transport at the Trans-Golgi-Network	35	8.21e-02	2.59e-01	0.22000	-0.174000	-0.134000	7.43e-02	0.169000
AURKA Activation by TPX2	57	1.62e-02	1.02e-01	0.22000	-0.220000	0.000611	4.08e-03	0.994000
RUNX1 regulates transcription of genes involved in differentiation of HSCs	49	2.74e-02	1.33e-01	0.22000	0.170000	-0.140000	4.00e-02	0.090300
Regulation of activated PAK-2p34 by proteasome mediated degradation	32	9.60e-02	2.85e-01	0.22000	0.195000	-0.102000	5.67e-02	0.319000
Selective autophagy	43	4.60e-02	1.89e-01	0.22000	-0.058900	-0.212000	5.05e-01	0.016400
Iron uptake and transport	36	7.71e-02	2.50e-01	0.22000	0.185000	0.119000	5.55e-02	0.216000
NIK-->noncanonical NF-kB signaling	37	6.66e-02	2.27e-01	0.22000	0.132000	-0.176000	1.65e-01	0.064700
Autodegradation of the E3 ubiquitin ligase COP1	34	8.29e-02	2.61e-01	0.22000	0.170000	-0.139000	8.57e-02	0.162000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	3.88e-01	5.87e-01	0.21900	0.195000	-0.101000	2.24e-01	0.530000
Telomere Maintenance	42	4.97e-02	1.97e-01	0.21800	-0.217000	0.022100	1.49e-02	0.805000
Post-translational protein phosphorylation	59	1.58e-02	1.00e-01	0.21800	0.201000	0.085400	7.68e-03	0.257000
Transport of Mature Transcript to Cytoplasm	59	1.59e-02	1.01e-01	0.21800	-0.193000	-0.101000	1.03e-02	0.180000
FCGR3A-mediated IL10 synthesis	36	7.93e-02	2.55e-01	0.21800	0.209000	0.063200	3.05e-02	0.512000
Fatty acyl-CoA biosynthesis	22	2.08e-01	4.25e-01	0.21800	-0.216000	0.030900	8.02e-02	0.802000
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	17	3.04e-01	5.11e-01	0.21800	-0.103000	-0.192000	4.64e-01	0.171000
Phase 2 - plateau phase	17	2.98e-01	5.05e-01	0.21800	-0.214000	0.038400	1.27e-01	0.784000
Golgi Cisternae Pericentriolar Stack Reorganization	11	4.65e-01	6.53e-01	0.21700	0.153000	0.154000	3.80e-01	0.377000
AUF1 (hnRNP D0) binds and destabilizes mRNA	35	8.24e-02	2.60e-01	0.21700	0.140000	-0.165000	1.51e-01	0.090900
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	4.93e-01	6.77e-01	0.21700	0.029300	-0.215000	8.73e-01	0.240000
Purine catabolism	12	4.25e-01	6.21e-01	0.21700	0.185000	-0.113000	2.68e-01	0.498000
Transport of inorganic cations/anions and amino acids/oligopeptides	68	8.33e-03	6.32e-02	0.21700	-0.211000	0.048900	2.66e-03	0.486000
Interleukin-4 and Interleukin-13 signaling	78	4.23e-03	3.98e-02	0.21600	0.213000	-0.039200	1.19e-03	0.551000
APC/C:Cdc20 mediated degradation of Securin	48	3.35e-02	1.52e-01	0.21600	0.137000	-0.167000	1.02e-01	0.045300
RNA Polymerase I Transcription	33	1.04e-01	2.94e-01	0.21600	-0.110000	-0.185000	2.73e-01	0.065400
Interferon Signaling	114	3.84e-04	7.88e-03	0.21500	0.206000	-0.060500	1.51e-04	0.266000
LDL clearance	13	4.05e-01	6.04e-01	0.21400	0.091000	-0.194000	5.70e-01	0.226000
G2/M DNA damage checkpoint	43	5.48e-02	2.06e-01	0.21400	-0.136000	-0.165000	1.22e-01	0.061100
Loss of Nlp from mitotic centrosomes	55	2.34e-02	1.25e-01	0.21400	-0.214000	-0.006240	6.15e-03	0.936000
Loss of proteins required for interphase microtubule organization from the centrosome	55	2.34e-02	1.25e-01	0.21400	-0.214000	-0.006240	6.15e-03	0.936000
RHO GTPases Activate Formins	87	2.82e-03	3.35e-02	0.21400	-0.209000	-0.045400	7.85e-04	0.465000
RNA Polymerase II Pre-transcription Events	51	3.27e-02	1.50e-01	0.21300	-0.174000	-0.124000	3.20e-02	0.126000
Cell Cycle Checkpoints	181	6.82e-06	3.80e-04	0.21300	-0.151000	-0.150000	4.83e-04	0.000543
Processing of DNA double-strand break ends	41	6.59e-02	2.26e-01	0.21200	-0.131000	-0.167000	1.47e-01	0.064500
DNA Damage Bypass	29	1.39e-01	3.38e-01	0.21200	-0.199000	0.073400	6.39e-02	0.494000
Signaling by FGFR2	39	7.63e-02	2.48e-01	0.21100	-0.199000	-0.070000	3.16e-02	0.450000
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	3.72e-01	5.74e-01	0.21100	-0.192000	-0.088300	1.99e-01	0.554000
Synthesis of IP3 and IP4 in the cytosol	20	2.68e-01	4.81e-01	0.21100	0.072500	0.198000	5.75e-01	0.126000
Cellular Senescence	100	1.48e-03	2.06e-02	0.21100	-0.180000	-0.110000	1.95e-03	0.057700
PI3K Cascade	29	1.46e-01	3.45e-01	0.21000	-0.210000	0.016300	5.07e-02	0.879000
PD-1 signaling	11	4.86e-01	6.71e-01	0.21000	-0.188000	-0.093600	2.79e-01	0.591000
Plasma lipoprotein remodeling	19	2.79e-01	4.91e-01	0.21000	0.147000	-0.151000	2.68e-01	0.256000
KSRP (KHSRP) binds and destabilizes mRNA	13	4.18e-01	6.13e-01	0.21000	-0.167000	0.128000	2.97e-01	0.426000
Insulin receptor signalling cascade	37	8.73e-02	2.69e-01	0.21000	-0.210000	0.003310	2.73e-02	0.972000
BMAL1:CLOCK,NPAS2 activates circadian gene expression	19	2.81e-01	4.91e-01	0.21000	-0.155000	0.141000	2.42e-01	0.288000
Negative epigenetic regulation of rRNA expression	28	1.62e-01	3.69e-01	0.21000	-0.097200	-0.186000	3.74e-01	0.089100
Apoptotic factor-mediated response	11	4.85e-01	6.70e-01	0.21000	0.209000	0.006050	2.29e-01	0.972000
Prolonged ERK activation events	12	4.51e-01	6.39e-01	0.20900	-0.159000	0.136000	3.42e-01	0.414000
Synthesis of PA	25	1.99e-01	4.17e-01	0.20900	-0.196000	-0.070500	8.94e-02	0.542000
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	18	3.09e-01	5.17e-01	0.20800	-0.193000	0.076200	1.56e-01	0.576000
RET signaling	31	1.33e-01	3.32e-01	0.20700	-0.187000	0.089800	7.18e-02	0.387000
Inositol phosphate metabolism	36	9.89e-02	2.87e-01	0.20700	-0.007070	0.207000	9.42e-01	0.031700
ERBB2 Regulates Cell Motility	11	4.92e-01	6.76e-01	0.20700	0.048200	-0.201000	7.82e-01	0.248000
CD28 co-stimulation	28	1.72e-01	3.83e-01	0.20600	-0.102000	-0.180000	3.52e-01	0.100000
Glycogen metabolism	18	3.17e-01	5.24e-01	0.20600	-0.024700	0.205000	8.56e-01	0.133000
RNA Polymerase I Transcription Initiation	29	1.63e-01	3.69e-01	0.20600	-0.095800	-0.182000	3.72e-01	0.089700
Dual incision in TC-NER	42	7.16e-02	2.37e-01	0.20600	-0.198000	-0.054200	2.62e-02	0.544000
Termination of translesion DNA synthesis	20	2.81e-01	4.91e-01	0.20500	-0.203000	0.029700	1.16e-01	0.818000
Inactivation of APC/C via direct inhibition of the APC/C complex	18	3.27e-01	5.35e-01	0.20400	-0.042800	-0.200000	7.53e-01	0.143000
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	18	3.27e-01	5.35e-01	0.20400	-0.042800	-0.200000	7.53e-01	0.143000
ABC transporter disorders	45	5.88e-02	2.12e-01	0.20400	0.187000	-0.082600	3.04e-02	0.338000
Dectin-1 mediated noncanonical NF-kB signaling	39	8.53e-02	2.66e-01	0.20400	0.121000	-0.164000	1.92e-01	0.076000
Chondroitin sulfate/dermatan sulfate metabolism	37	9.98e-02	2.88e-01	0.20400	0.202000	-0.024300	3.34e-02	0.798000
Extra-nuclear estrogen signaling	55	3.50e-02	1.56e-01	0.20300	-0.065500	-0.192000	4.01e-01	0.013800
CaM pathway	28	1.74e-01	3.84e-01	0.20300	-0.124000	0.161000	2.58e-01	0.141000
Calmodulin induced events	28	1.74e-01	3.84e-01	0.20300	-0.124000	0.161000	2.58e-01	0.141000
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	11	5.03e-01	6.83e-01	0.20300	-0.113000	0.168000	5.15e-01	0.335000
Signaling by ERBB2	34	1.29e-01	3.30e-01	0.20200	-0.094700	-0.178000	3.39e-01	0.072200
Mismatch Repair	13	4.50e-01	6.38e-01	0.20200	-0.192000	0.061300	2.31e-01	0.702000
Formation of Incision Complex in GG-NER	27	1.90e-01	4.08e-01	0.20100	-0.107000	0.171000	3.37e-01	0.125000
Aberrant regulation of mitotic cell cycle due to RB1 defects	30	1.66e-01	3.73e-01	0.20100	-0.092900	-0.179000	3.79e-01	0.090500
Diseases of mitotic cell cycle	30	1.66e-01	3.73e-01	0.20100	-0.092900	-0.179000	3.79e-01	0.090500
Downstream signaling of activated FGFR1	18	3.37e-01	5.49e-01	0.20100	-0.200000	0.017000	1.42e-01	0.900000
RNA Polymerase I Promoter Clearance	32	1.50e-01	3.50e-01	0.20000	-0.105000	-0.171000	3.04e-01	0.094900
Ovarian tumor domain proteases	26	2.17e-01	4.31e-01	0.20000	-0.174000	-0.098200	1.25e-01	0.386000
Vpu mediated degradation of CD4	33	1.38e-01	3.37e-01	0.19900	0.176000	-0.092500	8.00e-02	0.358000
Purine ribonucleoside monophosphate biosynthesis	11	5.17e-01	6.92e-01	0.19900	0.064800	-0.188000	7.10e-01	0.280000
Regulation of insulin secretion	55	3.72e-02	1.62e-01	0.19900	-0.171000	0.102000	2.86e-02	0.192000
CDK-mediated phosphorylation and removal of Cdc6	50	5.02e-02	1.98e-01	0.19900	0.100000	-0.172000	2.20e-01	0.035900
Regulation of Apoptosis	34	1.31e-01	3.31e-01	0.19900	0.175000	-0.093700	7.73e-02	0.345000
Stabilization of p53	37	1.10e-01	3.02e-01	0.19800	0.108000	-0.166000	2.54e-01	0.080600
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	53	4.29e-02	1.78e-01	0.19800	0.080600	-0.181000	3.11e-01	0.022600
MHC class II antigen presentation	82	7.70e-03	6.11e-02	0.19800	0.102000	-0.170000	1.11e-01	0.007870
Cell Cycle, Mitotic	353	2.98e-09	5.24e-07	0.19700	-0.180000	-0.078400	7.60e-09	0.012000
Mitochondrial translation	61	2.96e-02	1.41e-01	0.19600	0.195000	-0.021800	8.48e-03	0.768000
FRS-mediated FGFR3 signaling	10	5.64e-01	7.31e-01	0.19600	-0.195000	-0.021400	2.87e-01	0.907000
Ca2+ pathway	47	6.57e-02	2.26e-01	0.19600	-0.125000	0.151000	1.40e-01	0.074100
Costimulation by the CD28 family	48	6.78e-02	2.28e-01	0.19500	-0.127000	-0.148000	1.28e-01	0.075800
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	59	3.62e-02	1.60e-01	0.19500	0.186000	0.057300	1.34e-02	0.447000
Adherens junctions interactions	13	4.76e-01	6.60e-01	0.19500	0.017800	-0.194000	9.11e-01	0.226000
Collagen formation	60	3.48e-02	1.56e-01	0.19400	0.190000	0.038500	1.09e-02	0.606000
Signaling by TGF-beta Receptor Complex	48	6.75e-02	2.28e-01	0.19400	-0.194000	-0.007330	2.03e-02	0.930000
Sphingolipid metabolism	54	4.63e-02	1.89e-01	0.19400	0.167000	-0.098200	3.37e-02	0.212000
Cell Cycle	439	6.62e-11	2.69e-08	0.19400	-0.169000	-0.094300	1.77e-09	0.000802
Platelet degranulation	86	8.33e-03	6.32e-02	0.19400	0.193000	0.011700	1.99e-03	0.851000
Activation of GABAB receptors	28	2.12e-01	4.25e-01	0.19300	0.178000	0.076200	1.04e-01	0.485000
GABA B receptor activation	28	2.12e-01	4.25e-01	0.19300	0.178000	0.076200	1.04e-01	0.485000
Meiotic recombination	19	3.49e-01	5.57e-01	0.19300	-0.056000	-0.185000	6.73e-01	0.163000
G-protein beta:gamma signalling	20	3.23e-01	5.31e-01	0.19300	0.146000	-0.125000	2.57e-01	0.332000
Nucleobase biosynthesis	13	4.82e-01	6.67e-01	0.19200	0.078300	-0.176000	6.25e-01	0.273000
RNA Polymerase III Chain Elongation	11	5.46e-01	7.16e-01	0.19200	0.187000	0.044600	2.83e-01	0.798000
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	36	1.37e-01	3.36e-01	0.19200	-0.192000	-0.015900	4.68e-02	0.869000
FRS-mediated FGFR4 signaling	10	5.73e-01	7.38e-01	0.19200	-0.185000	0.052300	3.12e-01	0.775000
Metabolism of polyamines	39	1.15e-01	3.07e-01	0.19200	0.183000	-0.058700	4.85e-02	0.526000
Signaling by KIT in disease	16	4.09e-01	6.05e-01	0.19200	-0.158000	0.110000	2.75e-01	0.448000
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	4.09e-01	6.05e-01	0.19200	-0.158000	0.110000	2.75e-01	0.448000
Glutamate and glutamine metabolism	12	5.19e-01	6.93e-01	0.19200	0.182000	0.060500	2.75e-01	0.717000
Signaling by NTRK3 (TRKC)	14	4.63e-01	6.51e-01	0.19200	-0.192000	-0.003690	2.14e-01	0.981000
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	13	4.97e-01	6.79e-01	0.19100	-0.147000	-0.122000	3.60e-01	0.446000
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	13	4.97e-01	6.79e-01	0.19100	-0.147000	-0.122000	3.60e-01	0.446000
Degradation of AXIN	35	1.45e-01	3.44e-01	0.19100	0.110000	-0.156000	2.58e-01	0.111000
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	11	5.48e-01	7.18e-01	0.19100	-0.006170	0.191000	9.72e-01	0.274000
ABC transporters in lipid homeostasis	12	5.23e-01	6.95e-01	0.19100	-0.184000	-0.048700	2.69e-01	0.770000
Caspase-mediated cleavage of cytoskeletal proteins	10	5.78e-01	7.44e-01	0.19000	-0.182000	0.054700	3.18e-01	0.765000
Regulation of PTEN stability and activity	44	9.01e-02	2.72e-01	0.19000	0.090200	-0.167000	3.01e-01	0.055000
mRNA Splicing - Minor Pathway	30	2.02e-01	4.18e-01	0.19000	-0.114000	-0.152000	2.78e-01	0.150000
Caspase activation via Death Receptors in the presence of ligand	14	4.64e-01	6.52e-01	0.19000	0.104000	-0.159000	5.02e-01	0.303000
Diseases of programmed cell death	18	3.74e-01	5.74e-01	0.19000	-0.078000	0.173000	5.67e-01	0.203000
Collagen chain trimerization	32	1.78e-01	3.90e-01	0.19000	0.189000	-0.016000	6.45e-02	0.875000
Phosphorylation of CD3 and TCR zeta chains	12	5.29e-01	7.01e-01	0.18900	-0.114000	-0.151000	4.94e-01	0.365000
Dopamine Neurotransmitter Release Cycle	12	5.21e-01	6.94e-01	0.18900	-0.086400	0.168000	6.04e-01	0.312000
CDT1 association with the CDC6:ORC:origin complex	38	1.27e-01	3.27e-01	0.18900	0.098900	-0.161000	2.92e-01	0.085600
PI-3K cascade:FGFR2	13	4.94e-01	6.77e-01	0.18900	-0.153000	0.111000	3.39e-01	0.490000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	68	2.78e-02	1.34e-01	0.18900	0.183000	0.046100	9.18e-03	0.511000
MicroRNA (miRNA) biogenesis	13	5.05e-01	6.84e-01	0.18900	-0.150000	-0.115000	3.50e-01	0.474000
Listeria monocytogenes entry into host cells	13	5.05e-01	6.84e-01	0.18900	-0.089200	-0.166000	5.78e-01	0.300000
Nonhomologous End-Joining (NHEJ)	24	2.86e-01	4.95e-01	0.18700	-0.054200	-0.179000	6.46e-01	0.128000
ISG15 antiviral mechanism	46	9.20e-02	2.76e-01	0.18700	-0.174000	-0.068500	4.10e-02	0.422000
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	5.91e-01	7.50e-01	0.18700	0.010400	-0.187000	9.55e-01	0.306000
Protein ubiquitination	37	1.43e-01	3.43e-01	0.18600	-0.170000	0.076400	7.36e-02	0.422000
PIWI-interacting RNA (piRNA) biogenesis	10	5.97e-01	7.54e-01	0.18600	-0.174000	-0.067100	3.41e-01	0.713000
Phase II - Conjugation of compounds	63	3.81e-02	1.65e-01	0.18600	0.186000	-0.004480	1.06e-02	0.951000
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	25	2.72e-01	4.83e-01	0.18500	-0.168000	0.077500	1.45e-01	0.502000
COPI-dependent Golgi-to-ER retrograde traffic	57	5.47e-02	2.06e-01	0.18500	-0.016500	-0.184000	8.30e-01	0.016200
RNA Polymerase III Transcription Termination	15	4.68e-01	6.55e-01	0.18500	0.162000	0.088900	2.77e-01	0.551000
Regulation of ornithine decarboxylase (ODC)	34	1.73e-01	3.84e-01	0.18500	0.172000	-0.067300	8.25e-02	0.497000
RUNX2 regulates osteoblast differentiation	17	4.19e-01	6.13e-01	0.18500	0.185000	-0.002900	1.87e-01	0.983000
DNA Damage Recognition in GG-NER	24	2.89e-01	4.97e-01	0.18500	-0.084400	0.164000	4.74e-01	0.163000
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	5.17e-01	6.92e-01	0.18500	-0.178000	-0.048600	2.66e-01	0.761000
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	3.13e-01	5.19e-01	0.18500	-0.171000	-0.069700	1.56e-01	0.563000
FCGR3A-mediated phagocytosis	54	6.28e-02	2.21e-01	0.18400	0.175000	-0.059200	2.66e-02	0.452000
Leishmania phagocytosis	54	6.28e-02	2.21e-01	0.18400	0.175000	-0.059200	2.66e-02	0.452000
Parasite infection	54	6.28e-02	2.21e-01	0.18400	0.175000	-0.059200	2.66e-02	0.452000
CD209 (DC-SIGN) signaling	17	4.16e-01	6.12e-01	0.18400	-0.151000	0.105000	2.81e-01	0.452000
Aquaporin-mediated transport	31	2.10e-01	4.25e-01	0.18400	0.026100	0.182000	8.02e-01	0.079500
Cell-extracellular matrix interactions	14	4.87e-01	6.71e-01	0.18400	0.108000	-0.149000	4.84e-01	0.335000
mRNA Splicing - Major Pathway	116	3.30e-03	3.49e-02	0.18300	-0.149000	-0.107000	5.58e-03	0.048000
Ca-dependent events	30	2.18e-01	4.31e-01	0.18300	-0.089500	0.160000	3.96e-01	0.130000
Dual Incision in GG-NER	30	2.22e-01	4.36e-01	0.18300	-0.178000	0.041100	9.21e-02	0.697000
Gamma carboxylation, hypusine formation and arylsulfatase activation	21	3.47e-01	5.56e-01	0.18200	0.150000	-0.103000	2.33e-01	0.415000
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	35	1.73e-01	3.84e-01	0.18200	0.161000	-0.085000	1.00e-01	0.385000
Trafficking of GluR2-containing AMPA receptors	10	6.14e-01	7.64e-01	0.18200	-0.150000	-0.103000	4.12e-01	0.573000
NOTCH4 Intracellular Domain Regulates Transcription	18	4.13e-01	6.10e-01	0.18100	-0.024200	-0.180000	8.59e-01	0.187000
FGFR1 mutant receptor activation	21	3.55e-01	5.63e-01	0.18000	-0.078800	0.162000	5.32e-01	0.198000
PECAM1 interactions	10	6.16e-01	7.66e-01	0.18000	0.052200	0.173000	7.75e-01	0.344000
Processing of Capped Intron-Containing Pre-mRNA	160	4.96e-04	9.41e-03	0.18000	-0.163000	-0.077000	3.88e-04	0.094100
Cytochrome P450 - arranged by substrate type	29	2.49e-01	4.61e-01	0.18000	0.104000	0.148000	3.35e-01	0.169000
NOTCH1 Intracellular Domain Regulates Transcription	37	1.62e-01	3.68e-01	0.18000	-0.138000	0.116000	1.47e-01	0.223000
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	10	6.18e-01	7.67e-01	0.18000	0.065100	0.168000	7.22e-01	0.358000
Transport of Mature mRNA derived from an Intron-Containing Transcript	53	7.97e-02	2.56e-01	0.18000	-0.149000	-0.101000	6.03e-02	0.206000
Transcriptional regulation of white adipocyte differentiation	65	4.46e-02	1.84e-01	0.18000	-0.169000	-0.060600	1.83e-02	0.399000
Signaling by FGFR in disease	38	1.56e-01	3.59e-01	0.18000	-0.164000	0.073200	7.98e-02	0.435000
RNA Polymerase I Transcription Termination	16	4.61e-01	6.49e-01	0.18000	-0.007040	-0.180000	9.61e-01	0.213000
Degradation of cysteine and homocysteine	11	5.85e-01	7.48e-01	0.18000	-0.171000	0.054600	3.26e-01	0.754000
SUMOylation of transcription factors	12	5.62e-01	7.30e-01	0.17900	-0.179000	-0.017200	2.84e-01	0.918000
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	5.59e-01	7.29e-01	0.17900	-0.170000	0.057100	3.09e-01	0.732000
Elevation of cytosolic Ca2+ levels	10	6.23e-01	7.71e-01	0.17900	-0.071700	-0.164000	6.95e-01	0.370000
Mitotic Prophase	62	5.15e-02	2.02e-01	0.17900	-0.175000	0.034400	1.72e-02	0.640000
HATs acetylate histones	58	6.73e-02	2.28e-01	0.17800	-0.162000	-0.071900	3.26e-02	0.345000
Separation of Sister Chromatids	122	3.72e-03	3.64e-02	0.17700	-0.120000	-0.130000	2.22e-02	0.013400
Acyl chain remodelling of PS	14	5.20e-01	6.94e-01	0.17700	0.175000	0.027900	2.57e-01	0.857000
Metabolism of cofactors	17	4.46e-01	6.35e-01	0.17700	0.087900	-0.154000	5.31e-01	0.273000
Nuclear Receptor transcription pathway	41	1.45e-01	3.44e-01	0.17700	-0.077400	0.159000	3.92e-01	0.079100
Polymerase switching on the C-strand of the telomere	21	3.75e-01	5.74e-01	0.17700	-0.176000	0.010700	1.62e-01	0.932000
Interleukin-17 signaling	54	7.92e-02	2.55e-01	0.17600	-0.164000	0.065300	3.75e-02	0.407000
The role of Nef in HIV-1 replication and disease pathogenesis	22	3.54e-01	5.63e-01	0.17600	-0.083500	0.155000	4.98e-01	0.207000
Activation of RAC1	10	6.33e-01	7.77e-01	0.17600	-0.159000	-0.075000	3.85e-01	0.681000
MAP kinase activation	50	9.80e-02	2.87e-01	0.17500	-0.164000	0.063600	4.57e-02	0.437000
Nephrin family interactions	17	4.57e-01	6.44e-01	0.17500	-0.175000	0.008300	2.11e-01	0.953000
Nuclear signaling by ERBB4	23	3.42e-01	5.54e-01	0.17500	0.126000	-0.121000	2.94e-01	0.315000
Signaling by ERBB2 in Cancer	20	4.08e-01	6.05e-01	0.17400	-0.117000	-0.129000	3.65e-01	0.317000
Keratan sulfate biosynthesis	17	4.56e-01	6.44e-01	0.17400	-0.085900	0.152000	5.40e-01	0.279000
Negative regulation of MAPK pathway	32	2.31e-01	4.47e-01	0.17400	-0.169000	0.044300	9.89e-02	0.664000
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	41	1.55e-01	3.59e-01	0.17400	0.174000	0.000828	5.36e-02	0.993000
Nuclear Envelope (NE) Reassembly	52	9.63e-02	2.85e-01	0.17400	-0.168000	-0.046100	3.62e-02	0.566000
Regulation of lipid metabolism by PPARalpha	91	1.76e-02	1.05e-01	0.17400	-0.143000	-0.099500	1.89e-02	0.102000
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	6.32e-01	7.77e-01	0.17400	-0.119000	0.127000	5.14e-01	0.488000
Signaling by NOTCH3	36	1.99e-01	4.17e-01	0.17400	-0.028300	-0.171000	7.69e-01	0.075500
MAPK targets/ Nuclear events mediated by MAP kinases	27	2.97e-01	5.05e-01	0.17300	-0.173000	0.005650	1.20e-01	0.959000
Signaling by Retinoic Acid	30	2.57e-01	4.69e-01	0.17300	-0.150000	0.086700	1.56e-01	0.411000
Regulation of actin dynamics for phagocytic cup formation	55	8.33e-02	2.61e-01	0.17300	0.115000	-0.129000	1.41e-01	0.098700
The canonical retinoid cycle in rods (twilight vision)	13	5.56e-01	7.26e-01	0.17200	-0.128000	0.116000	4.25e-01	0.470000
G2/M Checkpoints	89	2.03e-02	1.14e-01	0.17200	-0.056600	-0.163000	3.57e-01	0.008060
Metal ion SLC transporters	18	4.45e-01	6.35e-01	0.17200	0.130000	-0.112000	3.39e-01	0.410000
Generation of second messenger molecules	21	4.01e-01	6.03e-01	0.17200	-0.148000	-0.087500	2.42e-01	0.488000
Neurotransmitter release cycle	26	3.14e-01	5.20e-01	0.17200	-0.150000	0.083500	1.86e-01	0.461000
Mitotic Anaphase	164	9.18e-04	1.45e-02	0.17100	-0.117000	-0.125000	9.74e-03	0.006130
MTOR signalling	30	2.69e-01	4.81e-01	0.17100	-0.171000	0.004360	1.05e-01	0.967000
IGF1R signaling cascade	35	2.18e-01	4.31e-01	0.17100	-0.169000	-0.023300	8.32e-02	0.811000
Glutathione conjugation	27	3.08e-01	5.15e-01	0.17000	0.161000	-0.056100	1.49e-01	0.614000
Response to elevated platelet cytosolic Ca2+	90	2.12e-02	1.16e-01	0.17000	0.169000	0.016600	5.65e-03	0.786000
Mitotic Metaphase and Anaphase	165	9.81e-04	1.53e-02	0.17000	-0.120000	-0.120000	8.09e-03	0.007940
Phosphorylation of the APC/C	17	4.82e-01	6.67e-01	0.17000	-0.034800	-0.166000	8.04e-01	0.236000
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	51	1.09e-01	3.00e-01	0.17000	0.101000	-0.136000	2.11e-01	0.093600
Ion homeostasis	37	2.04e-01	4.19e-01	0.16900	-0.169000	0.015400	7.60e-02	0.871000
TCF dependent signaling in response to WNT	117	6.37e-03	5.34e-02	0.16900	-0.135000	0.102000	1.18e-02	0.057000
Signaling by FGFR4	23	3.79e-01	5.79e-01	0.16800	-0.164000	-0.038000	1.74e-01	0.753000
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	52	1.09e-01	3.01e-01	0.16800	0.090200	-0.141000	2.61e-01	0.078200
Sulfur amino acid metabolism	18	4.73e-01	6.58e-01	0.16800	-0.159000	-0.053500	2.44e-01	0.695000
Switching of origins to a post-replicative state	62	7.46e-02	2.44e-01	0.16700	0.008590	-0.167000	9.07e-01	0.023000
Recycling pathway of L1	25	3.56e-01	5.63e-01	0.16700	-0.076300	-0.149000	5.09e-01	0.198000
Gastrin-CREB signalling pathway via PKC and MAPK	13	5.82e-01	7.48e-01	0.16700	-0.031500	-0.164000	8.44e-01	0.306000
Signaling by NTRK2 (TRKB)	18	4.70e-01	6.56e-01	0.16700	-0.047000	0.160000	7.30e-01	0.241000
Synthesis of substrates in N-glycan biosythesis	47	1.46e-01	3.45e-01	0.16600	0.156000	0.058500	6.48e-02	0.488000
TICAM1, RIP1-mediated IKK complex recruitment	12	6.06e-01	7.61e-01	0.16600	-0.163000	0.034700	3.29e-01	0.835000
IRS-related events triggered by IGF1R	34	2.45e-01	4.57e-01	0.16600	-0.166000	0.000650	9.36e-02	0.995000
Post NMDA receptor activation events	48	1.36e-01	3.35e-01	0.16600	-0.162000	0.037600	5.27e-02	0.653000
RHO GTPases Activate NADPH Oxidases	18	4.71e-01	6.57e-01	0.16600	0.106000	-0.128000	4.38e-01	0.348000
M Phase	255	4.04e-05	1.61e-03	0.16600	-0.140000	-0.088700	1.31e-04	0.015300
Basigin interactions	21	4.23e-01	6.18e-01	0.16600	-0.002560	-0.165000	9.84e-01	0.189000
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	6.41e-01	7.81e-01	0.16500	-0.056400	-0.155000	7.46e-01	0.373000
Notch-HLH transcription pathway	22	4.13e-01	6.10e-01	0.16500	-0.112000	-0.121000	3.65e-01	0.324000
NoRC negatively regulates rRNA expression	25	3.65e-01	5.72e-01	0.16500	-0.064900	-0.152000	5.75e-01	0.190000
HS-GAG degradation	15	5.43e-01	7.14e-01	0.16500	0.164000	-0.012300	2.71e-01	0.934000
Telomere C-strand synthesis initiation	11	6.37e-01	7.79e-01	0.16400	-0.142000	0.082900	4.15e-01	0.634000
RHO GTPases activate IQGAPs	10	6.72e-01	8.10e-01	0.16400	0.084100	0.141000	6.45e-01	0.441000
PPARA activates gene expression	89	2.99e-02	1.42e-01	0.16400	-0.133000	-0.095600	3.03e-02	0.120000
Factors involved in megakaryocyte development and platelet production	80	4.14e-02	1.73e-01	0.16400	-0.162000	-0.023600	1.23e-02	0.716000
Interleukin-3, Interleukin-5 and GM-CSF signaling	32	2.76e-01	4.87e-01	0.16300	-0.067400	0.149000	5.09e-01	0.146000
Role of LAT2/NTAL/LAB on calcium mobilization	13	5.92e-01	7.50e-01	0.16300	-0.092700	0.134000	5.63e-01	0.403000
p53-Dependent G1 DNA Damage Response	43	1.82e-01	3.95e-01	0.16200	0.052300	-0.153000	5.53e-01	0.082100
p53-Dependent G1/S DNA damage checkpoint	43	1.82e-01	3.95e-01	0.16200	0.052300	-0.153000	5.53e-01	0.082100
Signaling by NOTCH4	59	9.71e-02	2.87e-01	0.16200	0.098400	-0.128000	1.92e-01	0.089000
Degradation of GLI1 by the proteasome	37	2.32e-01	4.48e-01	0.16100	0.143000	-0.074900	1.33e-01	0.431000
TRAF3-dependent IRF activation pathway	12	6.30e-01	7.77e-01	0.16100	-0.077400	-0.141000	6.42e-01	0.397000
Senescence-Associated Secretory Phenotype (SASP)	37	2.39e-01	4.53e-01	0.16100	-0.021900	-0.160000	8.18e-01	0.093000
Regulation of necroptotic cell death	12	6.24e-01	7.72e-01	0.16100	0.048600	-0.154000	7.71e-01	0.357000
Mitochondrial calcium ion transport	16	5.39e-01	7.11e-01	0.16000	-0.006260	0.160000	9.65e-01	0.267000
S Phase	115	1.32e-02	8.78e-02	0.16000	-0.115000	-0.112000	3.33e-02	0.039300
Signaling by ERBB4	35	2.62e-01	4.74e-01	0.16000	-0.001070	-0.160000	9.91e-01	0.102000
tRNA processing in the nucleus	41	2.12e-01	4.25e-01	0.16000	-0.154000	-0.043100	8.85e-02	0.633000
Nucleotide Excision Repair	74	5.84e-02	2.11e-01	0.16000	-0.149000	0.056400	2.65e-02	0.402000
Deubiquitination	180	1.19e-03	1.78e-02	0.16000	-0.158000	-0.021500	2.68e-04	0.621000
GPCR ligand binding	189	8.47e-04	1.39e-02	0.15900	0.159000	0.013100	1.75e-04	0.757000
Signalling to ERKs	27	3.54e-01	5.63e-01	0.15900	-0.066800	0.145000	5.48e-01	0.194000
RHO GTPases activate CIT	16	5.40e-01	7.11e-01	0.15900	-0.113000	0.112000	4.33e-01	0.439000
RAF-independent MAPK1/3 activation	18	5.02e-01	6.83e-01	0.15900	-0.059900	0.147000	6.60e-01	0.280000
Synthesis of PIPs at the early endosome membrane	14	5.86e-01	7.48e-01	0.15900	-0.153000	0.042300	3.21e-01	0.784000
Asymmetric localization of PCP proteins	45	1.87e-01	4.03e-01	0.15800	0.158000	-0.009500	6.77e-02	0.912000
APC/C:Cdc20 mediated degradation of mitotic proteins	54	1.31e-01	3.31e-01	0.15800	0.076800	-0.138000	3.29e-01	0.080100
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	54	1.31e-01	3.31e-01	0.15800	0.076800	-0.138000	3.29e-01	0.080100
Innate Immune System	651	1.09e-10	2.69e-08	0.15700	0.151000	-0.043400	9.02e-11	0.062700
Signaling by ERBB2 KD Mutants	19	5.00e-01	6.83e-01	0.15700	-0.121000	-0.101000	3.63e-01	0.447000
Meiosis	40	2.33e-01	4.49e-01	0.15700	-0.151000	-0.041000	9.81e-02	0.654000
Transcriptional regulation by RUNX2	77	5.73e-02	2.10e-01	0.15700	0.121000	-0.099400	6.64e-02	0.132000
ABC-family proteins mediated transport	64	9.30e-02	2.78e-01	0.15700	0.121000	-0.099000	9.37e-02	0.172000
Cargo concentration in the ER	18	5.12e-01	6.88e-01	0.15700	0.124000	-0.095200	3.62e-01	0.484000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	23	4.28e-01	6.21e-01	0.15600	-0.144000	0.061000	2.33e-01	0.613000
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	5.22e-01	6.95e-01	0.15600	-0.057700	-0.145000	6.72e-01	0.287000
SCF-beta-TrCP mediated degradation of Emi1	36	2.66e-01	4.78e-01	0.15600	0.138000	-0.072800	1.53e-01	0.450000
G alpha (z) signalling events	31	3.33e-01	5.43e-01	0.15500	0.104000	0.115000	3.16e-01	0.268000
HIV Transcription Initiation	30	3.45e-01	5.54e-01	0.15500	-0.074900	-0.136000	4.78e-01	0.199000
RNA Polymerase II HIV Promoter Escape	30	3.45e-01	5.54e-01	0.15500	-0.074900	-0.136000	4.78e-01	0.199000
RNA Polymerase II Promoter Escape	30	3.45e-01	5.54e-01	0.15500	-0.074900	-0.136000	4.78e-01	0.199000
RNA Polymerase II Transcription Initiation	30	3.45e-01	5.54e-01	0.15500	-0.074900	-0.136000	4.78e-01	0.199000
RNA Polymerase II Transcription Initiation And Promoter Clearance	30	3.45e-01	5.54e-01	0.15500	-0.074900	-0.136000	4.78e-01	0.199000
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	30	3.45e-01	5.54e-01	0.15500	-0.074900	-0.136000	4.78e-01	0.199000
EPHA-mediated growth cone collapse	11	6.79e-01	8.14e-01	0.15400	0.139000	0.066700	4.25e-01	0.702000
Mitochondrial tRNA aminoacylation	12	6.51e-01	7.91e-01	0.15400	0.143000	-0.056400	3.91e-01	0.735000
Chaperone Mediated Autophagy	12	6.53e-01	7.93e-01	0.15300	0.044600	-0.147000	7.89e-01	0.379000
Intraflagellar transport	33	3.10e-01	5.17e-01	0.15300	0.142000	-0.057100	1.57e-01	0.570000
Signaling by ROBO receptors	112	1.95e-02	1.11e-01	0.15300	0.146000	-0.047200	7.88e-03	0.390000
APC/C:Cdc20 mediated degradation of Cyclin B	18	5.34e-01	7.06e-01	0.15300	-0.044700	-0.147000	7.43e-01	0.282000
SCF(Skp2)-mediated degradation of p27/p21	38	2.60e-01	4.71e-01	0.15300	0.122000	-0.092800	1.95e-01	0.322000
GP1b-IX-V activation signalling	10	7.01e-01	8.29e-01	0.15300	-0.081000	0.130000	6.57e-01	0.478000
FCERI mediated Ca+2 mobilization	24	4.33e-01	6.25e-01	0.15200	-0.152000	0.006210	1.97e-01	0.958000
Signaling by FGFR1	30	3.60e-01	5.68e-01	0.15200	-0.117000	-0.096500	2.66e-01	0.361000
Regulation of RUNX3 expression and activity	36	2.85e-01	4.94e-01	0.15200	0.088400	-0.123000	3.59e-01	0.201000
DARPP-32 events	19	5.15e-01	6.90e-01	0.15200	-0.093800	0.119000	4.79e-01	0.369000
Gene expression (Transcription)	857	1.93e-12	1.19e-09	0.15100	-0.149000	-0.024600	3.77e-13	0.231000
Transferrin endocytosis and recycling	17	5.64e-01	7.31e-01	0.15100	0.140000	0.057100	3.19e-01	0.684000
Initiation of Nuclear Envelope (NE) Reformation	15	6.02e-01	7.58e-01	0.15100	-0.145000	-0.040400	3.30e-01	0.786000
DAP12 interactions	24	4.37e-01	6.27e-01	0.15100	0.121000	-0.090200	3.06e-01	0.445000
Major pathway of rRNA processing in the nucleolus and cytosol	90	5.00e-02	1.98e-01	0.15100	0.088700	0.122000	1.47e-01	0.046300
Ub-specific processing proteases	121	1.85e-02	1.08e-01	0.15000	-0.124000	-0.085300	1.93e-02	0.106000
HIV Infection	148	7.73e-03	6.11e-02	0.15000	-0.082400	-0.125000	8.47e-02	0.008680
Syndecan interactions	16	5.90e-01	7.50e-01	0.15000	0.114000	0.096600	4.29e-01	0.504000
Hedgehog 'on' state	52	1.72e-01	3.84e-01	0.15000	0.121000	-0.087700	1.31e-01	0.274000
Metabolic disorders of biological oxidation enzymes	20	5.10e-01	6.87e-01	0.14900	-0.118000	0.090200	3.60e-01	0.485000
Degradation of DVL	36	3.02e-01	5.09e-01	0.14800	0.109000	-0.099700	2.57e-01	0.301000
Vasopressin regulates renal water homeostasis via Aquaporins	28	4.06e-01	6.04e-01	0.14800	0.076900	0.126000	4.82e-01	0.248000
GABA receptor activation	32	3.57e-01	5.65e-01	0.14800	0.132000	0.065300	1.96e-01	0.523000
Synthesis of DNA	84	6.88e-02	2.31e-01	0.14700	-0.070300	-0.129000	2.66e-01	0.040800
G1/S DNA Damage Checkpoints	44	2.38e-01	4.52e-01	0.14700	0.036400	-0.143000	6.76e-01	0.102000
MAP3K8 (TPL2)-dependent MAPK1/3 activation	10	7.20e-01	8.40e-01	0.14700	-0.120000	0.085400	5.12e-01	0.640000
PLC beta mediated events	43	2.45e-01	4.57e-01	0.14700	-0.078300	0.124000	3.75e-01	0.158000
Activation of HOX genes during differentiation	39	2.83e-01	4.92e-01	0.14700	-0.143000	0.030400	1.21e-01	0.743000
Activation of anterior HOX genes in hindbrain development during early embryogenesis	39	2.83e-01	4.92e-01	0.14700	-0.143000	0.030400	1.21e-01	0.743000
NOTCH2 Activation and Transmission of Signal to the Nucleus	11	7.06e-01	8.32e-01	0.14700	-0.114000	-0.092200	5.13e-01	0.597000
RNA Polymerase II Transcription Termination	45	2.44e-01	4.57e-01	0.14600	-0.078900	-0.123000	3.60e-01	0.155000
Acyl chain remodelling of PI	12	6.83e-01	8.18e-01	0.14500	0.145000	-0.009330	3.84e-01	0.955000
Glycosaminoglycan metabolism	81	7.91e-02	2.55e-01	0.14500	0.144000	0.023000	2.58e-02	0.721000
Signaling by FGFR	49	2.17e-01	4.31e-01	0.14500	-0.129000	-0.066300	1.18e-01	0.423000
Nitric oxide stimulates guanylate cyclase	18	5.63e-01	7.31e-01	0.14500	0.043700	-0.139000	7.49e-01	0.309000
FRS-mediated FGFR2 signaling	12	6.82e-01	8.18e-01	0.14500	-0.122000	0.077400	4.63e-01	0.643000
Mitotic G2-G2/M phases	127	2.06e-02	1.15e-01	0.14500	-0.120000	-0.081100	2.02e-02	0.116000
A tetrasaccharide linker sequence is required for GAG synthesis	17	5.90e-01	7.50e-01	0.14500	-0.138000	-0.041900	3.24e-01	0.765000
Myogenesis	22	5.08e-01	6.86e-01	0.14400	-0.084600	-0.117000	4.92e-01	0.342000
Anchoring of the basal body to the plasma membrane	74	1.03e-01	2.93e-01	0.14400	-0.133000	-0.057000	4.89e-02	0.397000
RNA Polymerase II Transcription	769	2.28e-10	4.69e-08	0.14400	-0.141000	-0.031100	6.74e-11	0.149000
Signaling by ERBB2 TMD/JMD mutants	16	6.11e-01	7.64e-01	0.14400	-0.057600	-0.132000	6.90e-01	0.361000
DNA Replication	91	6.33e-02	2.22e-01	0.14400	-0.095000	-0.108000	1.18e-01	0.075500
Signaling by PDGF	44	2.54e-01	4.67e-01	0.14400	-0.037500	0.139000	6.67e-01	0.111000
Processing of SMDT1	11	7.15e-01	8.38e-01	0.14400	0.073400	0.123000	6.73e-01	0.479000
CRMPs in Sema3A signaling	13	6.72e-01	8.10e-01	0.14400	0.138000	0.038800	3.88e-01	0.809000
mRNA Splicing	123	2.46e-02	1.27e-01	0.14300	-0.122000	-0.076200	2.03e-02	0.145000
The role of GTSE1 in G2/M progression after G2 checkpoint	39	2.97e-01	5.05e-01	0.14300	0.105000	-0.097700	2.59e-01	0.291000
Translocation of SLC2A4 (GLUT4) to the plasma membrane	43	2.64e-01	4.75e-01	0.14300	-0.121000	0.075800	1.69e-01	0.390000
G2/M Transition	125	2.42e-02	1.27e-01	0.14300	-0.118000	-0.079800	2.28e-02	0.125000
Translation of structural proteins	18	5.83e-01	7.48e-01	0.14200	0.135000	0.044100	3.21e-01	0.746000
Pre-NOTCH Processing in Golgi	14	6.54e-01	7.93e-01	0.14200	0.023800	-0.140000	8.77e-01	0.365000
Transcriptional Regulation by E2F6	27	4.48e-01	6.37e-01	0.14200	-0.122000	-0.072300	2.73e-01	0.516000
NOD1/2 Signaling Pathway	25	4.67e-01	6.53e-01	0.14200	-0.123000	0.070700	2.88e-01	0.541000
PRC2 methylates histones and DNA	11	7.22e-01	8.42e-01	0.14200	-0.102000	-0.097800	5.56e-01	0.575000
Integrin cell surface interactions	52	2.17e-01	4.31e-01	0.14100	0.128000	0.058600	1.10e-01	0.466000
Incretin synthesis, secretion, and inactivation	10	7.44e-01	8.49e-01	0.14100	-0.033000	-0.137000	8.57e-01	0.453000
Class A/1 (Rhodopsin-like receptors)	137	1.72e-02	1.04e-01	0.14100	0.137000	-0.034400	5.89e-03	0.488000
Signaling by FGFR3	24	4.94e-01	6.77e-01	0.14100	-0.129000	-0.057500	2.75e-01	0.626000
Semaphorin interactions	53	2.12e-01	4.25e-01	0.14100	0.131000	0.051100	9.89e-02	0.520000
Assembly of the pre-replicative complex	45	2.63e-01	4.75e-01	0.14000	0.029700	-0.137000	7.31e-01	0.111000
Termination of O-glycan biosynthesis	12	7.04e-01	8.30e-01	0.14000	-0.135000	-0.037200	4.17e-01	0.823000
Activation of NF-kappaB in B cells	43	2.79e-01	4.91e-01	0.14000	0.058400	-0.127000	5.08e-01	0.148000
Regulation of RUNX2 expression and activity	46	2.54e-01	4.67e-01	0.14000	0.097600	-0.101000	2.52e-01	0.238000
Heparan sulfate/heparin (HS-GAG) metabolism	34	3.63e-01	5.72e-01	0.14000	0.111000	-0.084900	2.61e-01	0.392000
Degradation of the extracellular matrix	69	1.36e-01	3.35e-01	0.13900	0.139000	-0.001520	4.57e-02	0.983000
Fanconi Anemia Pathway	22	5.25e-01	6.97e-01	0.13900	-0.134000	0.038900	2.78e-01	0.752000
Global Genome Nucleotide Excision Repair (GG-NER)	59	1.77e-01	3.89e-01	0.13900	-0.088400	0.107000	2.41e-01	0.154000
Signaling by Nuclear Receptors	168	9.40e-03	6.90e-02	0.13800	-0.110000	-0.083400	1.42e-02	0.063100
BBSome-mediated cargo-targeting to cilium	16	6.29e-01	7.76e-01	0.13800	0.115000	-0.076900	4.27e-01	0.594000
EPH-Ephrin signaling	70	1.34e-01	3.32e-01	0.13800	0.125000	-0.058000	7.02e-02	0.403000
Regulation of PTEN gene transcription	46	2.69e-01	4.81e-01	0.13800	-0.138000	0.010500	1.07e-01	0.902000
Generic Transcription Pathway	684	1.18e-08	1.46e-06	0.13800	-0.137000	-0.018900	2.02e-09	0.407000
G1/S Transition	90	7.99e-02	2.56e-01	0.13800	-0.132000	-0.040400	3.09e-02	0.509000
LGI-ADAM interactions	13	6.88e-01	8.21e-01	0.13800	-0.040300	0.132000	8.01e-01	0.411000
Mitotic G1 phase and G1/S transition	102	5.78e-02	2.10e-01	0.13800	-0.131000	-0.044100	2.31e-02	0.443000
Carboxyterminal post-translational modifications of tubulin	24	5.11e-01	6.87e-01	0.13700	-0.012900	0.136000	9.13e-01	0.249000
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	27	4.75e-01	6.59e-01	0.13600	0.125000	0.054400	2.61e-01	0.625000
FCERI mediated MAPK activation	24	5.09e-01	6.87e-01	0.13600	-0.092400	0.099900	4.34e-01	0.397000
Regulation of RAS by GAPs	46	2.83e-01	4.92e-01	0.13500	0.022900	-0.133000	7.88e-01	0.118000
Inactivation, recovery and regulation of the phototransduction cascade	18	6.14e-01	7.64e-01	0.13500	-0.133000	-0.024400	3.30e-01	0.858000
The phototransduction cascade	18	6.14e-01	7.64e-01	0.13500	-0.133000	-0.024400	3.30e-01	0.858000
Extracellular matrix organization	202	4.57e-03	4.15e-02	0.13500	0.135000	0.002130	1.03e-03	0.959000
Cargo trafficking to the periciliary membrane	33	4.04e-01	6.04e-01	0.13500	0.110000	-0.077800	2.75e-01	0.440000
PCP/CE pathway	63	1.80e-01	3.93e-01	0.13400	0.125000	-0.050300	8.78e-02	0.491000
Hedgehog 'off' state	69	1.61e-01	3.68e-01	0.13400	0.106000	0.081800	1.27e-01	0.241000
mRNA 3'-end processing	39	3.56e-01	5.63e-01	0.13400	-0.097300	-0.092400	2.94e-01	0.318000
Cardiac conduction	82	1.09e-01	3.01e-01	0.13400	-0.126000	0.046400	4.96e-02	0.468000
G-protein mediated events	44	3.06e-01	5.13e-01	0.13300	-0.059800	0.119000	4.93e-01	0.171000
Lysosome Vesicle Biogenesis	25	5.15e-01	6.90e-01	0.13300	-0.017700	-0.132000	8.79e-01	0.253000
Phase 0 - rapid depolarisation	29	4.63e-01	6.51e-01	0.13300	0.009010	0.133000	9.33e-01	0.215000
tRNA Aminoacylation	17	6.34e-01	7.77e-01	0.13300	0.079600	-0.106000	5.70e-01	0.448000
Intra-Golgi traffic	34	4.04e-01	6.04e-01	0.13300	0.080200	-0.106000	4.19e-01	0.287000
PI3K events in ERBB2 signaling	13	7.12e-01	8.38e-01	0.13200	-0.001160	-0.132000	9.94e-01	0.410000
NGF-stimulated transcription	29	4.66e-01	6.53e-01	0.13200	-0.120000	0.054300	2.63e-01	0.613000
RHO GTPase Effectors	185	9.58e-03	6.99e-02	0.13100	-0.116000	-0.062500	6.96e-03	0.145000
Interaction between L1 and Ankyrins	22	5.68e-01	7.33e-01	0.13100	0.004560	0.131000	9.70e-01	0.287000
trans-Golgi Network Vesicle Budding	48	2.88e-01	4.97e-01	0.13100	0.063100	-0.115000	4.50e-01	0.169000
Signaling by Insulin receptor	47	3.02e-01	5.09e-01	0.13100	-0.130000	-0.018100	1.24e-01	0.830000
CTLA4 inhibitory signaling	18	6.26e-01	7.74e-01	0.13100	0.103000	-0.080300	4.48e-01	0.555000
DNA Repair	194	7.83e-03	6.11e-02	0.13100	-0.124000	-0.041000	2.97e-03	0.328000
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	7.39e-01	8.46e-01	0.13100	0.108000	0.074100	5.19e-01	0.657000
Diseases of hemostasis	12	7.39e-01	8.46e-01	0.13100	0.108000	0.074100	5.19e-01	0.657000
MyD88 cascade initiated on plasma membrane	63	1.99e-01	4.17e-01	0.13000	-0.113000	0.065600	1.23e-01	0.369000
Toll Like Receptor 10 (TLR10) Cascade	63	1.99e-01	4.17e-01	0.13000	-0.113000	0.065600	1.23e-01	0.369000
Toll Like Receptor 5 (TLR5) Cascade	63	1.99e-01	4.17e-01	0.13000	-0.113000	0.065600	1.23e-01	0.369000
Golgi-to-ER retrograde transport	83	1.24e-01	3.23e-01	0.13000	-0.011900	-0.130000	8.51e-01	0.041600
Caspase activation via extrinsic apoptotic signalling pathway	21	5.85e-01	7.48e-01	0.13000	0.042900	-0.123000	7.34e-01	0.330000
The citric acid (TCA) cycle and respiratory electron transport	95	9.39e-02	2.80e-01	0.13000	-0.123000	-0.040600	3.80e-02	0.495000
Downstream signaling events of B Cell Receptor (BCR)	54	2.57e-01	4.69e-01	0.13000	-0.012000	-0.129000	8.79e-01	0.100000
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	7.38e-01	8.46e-01	0.13000	-0.127000	0.024900	4.45e-01	0.881000
GLI3 is processed to GLI3R by the proteasome	37	3.94e-01	5.96e-01	0.12900	0.125000	-0.031700	1.87e-01	0.739000
Orc1 removal from chromatin	45	3.25e-01	5.34e-01	0.12900	0.031300	-0.125000	7.17e-01	0.147000
Cellular response to hypoxia	49	2.97e-01	5.05e-01	0.12900	0.129000	0.002280	1.19e-01	0.978000
Antiviral mechanism by IFN-stimulated genes	52	2.82e-01	4.91e-01	0.12900	-0.114000	-0.060200	1.57e-01	0.454000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	21	5.91e-01	7.50e-01	0.12800	0.097300	-0.083800	4.40e-01	0.507000
Purine salvage	11	7.64e-01	8.61e-01	0.12800	-0.037400	-0.123000	8.30e-01	0.481000
Negative regulation of NMDA receptor-mediated neuronal transmission	15	6.90e-01	8.22e-01	0.12800	0.120000	-0.045000	4.22e-01	0.763000
Transport of vitamins, nucleosides, and related molecules	28	5.10e-01	6.87e-01	0.12800	0.092500	0.088200	3.97e-01	0.420000
Translocation of ZAP-70 to Immunological synapse	10	7.84e-01	8.74e-01	0.12700	-0.127000	0.005370	4.86e-01	0.977000
Sema4D induced cell migration and growth-cone collapse	16	6.77e-01	8.14e-01	0.12700	0.116000	-0.051500	4.22e-01	0.721000
Metabolism of folate and pterines	13	7.32e-01	8.46e-01	0.12700	0.013100	0.126000	9.35e-01	0.431000
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	67	1.97e-01	4.17e-01	0.12700	-0.114000	0.055700	1.07e-01	0.431000
Signaling by MET	52	2.93e-01	5.00e-01	0.12700	-0.090600	-0.088700	2.59e-01	0.269000
Acyl chain remodelling of PC	19	6.33e-01	7.77e-01	0.12600	0.122000	-0.031200	3.56e-01	0.814000
CD28 dependent Vav1 pathway	11	7.67e-01	8.63e-01	0.12600	0.121000	-0.037300	4.89e-01	0.831000
DNA Replication Pre-Initiation	57	2.66e-01	4.78e-01	0.12600	-0.067600	-0.106000	3.78e-01	0.167000
Intra-Golgi and retrograde Golgi-to-ER traffic	134	4.39e-02	1.82e-01	0.12600	-0.005880	-0.125000	9.07e-01	0.012400
mTORC1-mediated signalling	17	6.69e-01	8.09e-01	0.12600	-0.009510	0.125000	9.46e-01	0.372000
RHO GTPases activate PAKs	18	6.58e-01	7.97e-01	0.12500	0.056500	0.112000	6.78e-01	0.411000
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	52	2.99e-01	5.06e-01	0.12500	-0.115000	-0.049100	1.50e-01	0.540000
Synthesis of PIPs at the plasma membrane	47	3.27e-01	5.35e-01	0.12500	-0.071400	0.103000	3.98e-01	0.223000
Base Excision Repair	36	4.25e-01	6.21e-01	0.12500	-0.110000	0.060500	2.55e-01	0.531000
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	42	3.74e-01	5.74e-01	0.12500	-0.122000	0.024800	1.71e-01	0.781000
Constitutive Signaling by NOTCH1 PEST Domain Mutants	42	3.74e-01	5.74e-01	0.12500	-0.122000	0.024800	1.71e-01	0.781000
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	42	3.74e-01	5.74e-01	0.12500	-0.122000	0.024800	1.71e-01	0.781000
Signaling by NOTCH1 PEST Domain Mutants in Cancer	42	3.74e-01	5.74e-01	0.12500	-0.122000	0.024800	1.71e-01	0.781000
Signaling by NOTCH1 in Cancer	42	3.74e-01	5.74e-01	0.12500	-0.122000	0.024800	1.71e-01	0.781000
Host Interactions of HIV factors	88	1.36e-01	3.35e-01	0.12400	-0.098300	-0.076000	1.12e-01	0.219000
Signalling to RAS	15	7.06e-01	8.32e-01	0.12400	-0.024700	0.122000	8.68e-01	0.415000
Leishmania infection	157	2.75e-02	1.33e-01	0.12400	0.121000	-0.026500	9.05e-03	0.567000
RHO GTPases Activate ROCKs	13	7.40e-01	8.47e-01	0.12400	0.122000	-0.023700	4.48e-01	0.882000
Degradation of GLI2 by the proteasome	38	4.19e-01	6.13e-01	0.12400	0.123000	-0.011800	1.90e-01	0.900000
Protein localization	108	8.63e-02	2.69e-01	0.12300	0.023900	-0.121000	6.69e-01	0.030400
Protein folding	68	2.21e-01	4.36e-01	0.12300	0.097400	0.075000	1.65e-01	0.286000
Asparagine N-linked glycosylation	202	1.14e-02	7.87e-02	0.12300	0.123000	0.003610	2.77e-03	0.930000
RAF activation	27	5.46e-01	7.16e-01	0.12300	-0.122000	-0.016000	2.75e-01	0.886000
Signaling by NOTCH1	55	2.94e-01	5.03e-01	0.12200	-0.121000	0.011100	1.20e-01	0.887000
CLEC7A (Dectin-1) signaling	68	2.24e-01	4.38e-01	0.12200	-0.001850	-0.121000	9.79e-01	0.083700
SUMOylation of intracellular receptors	22	6.13e-01	7.64e-01	0.12100	-0.114000	0.042900	3.57e-01	0.728000
RIPK1-mediated regulated necrosis	14	7.33e-01	8.46e-01	0.12100	0.117000	-0.032400	4.50e-01	0.834000
Regulated Necrosis	14	7.33e-01	8.46e-01	0.12100	0.117000	-0.032400	4.50e-01	0.834000
Toll Like Receptor 3 (TLR3) Cascade	73	2.01e-01	4.17e-01	0.12100	-0.116000	0.035600	8.81e-02	0.600000
DCC mediated attractive signaling	12	7.69e-01	8.64e-01	0.12100	-0.002590	0.121000	9.88e-01	0.469000
Cleavage of the damaged pyrimidine	14	7.37e-01	8.46e-01	0.12100	-0.002420	-0.121000	9.88e-01	0.435000
Depyrimidination	14	7.37e-01	8.46e-01	0.12100	-0.002420	-0.121000	9.88e-01	0.435000
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	7.37e-01	8.46e-01	0.12100	-0.002420	-0.121000	9.88e-01	0.435000
Signaling by Non-Receptor Tyrosine Kinases	39	4.37e-01	6.27e-01	0.12000	0.052400	0.108000	5.71e-01	0.244000
Signaling by PTK6	39	4.37e-01	6.27e-01	0.12000	0.052400	0.108000	5.71e-01	0.244000
Phase I - Functionalization of compounds	56	3.02e-01	5.09e-01	0.12000	0.013500	0.119000	8.61e-01	0.124000
rRNA processing in the nucleus and cytosol	96	1.32e-01	3.31e-01	0.12000	0.068400	0.098500	2.48e-01	0.096200
Ras activation upon Ca2+ influx through NMDA receptor	15	7.26e-01	8.43e-01	0.12000	-0.119000	-0.006550	4.23e-01	0.965000
RMTs methylate histone arginines	25	5.86e-01	7.48e-01	0.11900	-0.118000	0.019200	3.09e-01	0.868000
Fcgamma receptor (FCGR) dependent phagocytosis	75	2.01e-01	4.17e-01	0.11900	0.094400	-0.072400	1.58e-01	0.279000
Acyl chain remodelling of PE	17	6.99e-01	8.29e-01	0.11900	0.119000	0.005340	3.98e-01	0.970000
Toll Like Receptor 9 (TLR9) Cascade	70	2.27e-01	4.40e-01	0.11800	-0.100000	0.063400	1.48e-01	0.360000
MyD88 dependent cascade initiated on endosome	68	2.38e-01	4.52e-01	0.11800	-0.097600	0.066700	1.65e-01	0.343000
Toll Like Receptor 7/8 (TLR7/8) Cascade	68	2.38e-01	4.52e-01	0.11800	-0.097600	0.066700	1.65e-01	0.343000
Platelet activation, signaling and aggregation	183	2.33e-02	1.25e-01	0.11800	0.118000	-0.001380	6.12e-03	0.975000
VxPx cargo-targeting to cilium	13	7.65e-01	8.61e-01	0.11700	0.117000	-0.005480	4.65e-01	0.973000
Transcriptional Regulation by MECP2	41	4.31e-01	6.22e-01	0.11700	-0.117000	0.005590	1.95e-01	0.951000
RUNX2 regulates bone development	22	6.37e-01	7.79e-01	0.11700	0.117000	0.009440	3.43e-01	0.939000
Biological oxidations	122	8.70e-02	2.69e-01	0.11700	0.101000	0.058800	5.46e-02	0.263000
Activation of BAD and translocation to mitochondria	13	7.70e-01	8.65e-01	0.11700	0.102000	0.056100	5.23e-01	0.726000
Reduction of cytosolic Ca++ levels	10	8.18e-01	8.95e-01	0.11600	-0.019300	0.114000	9.16e-01	0.532000
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	26	5.92e-01	7.50e-01	0.11500	-0.043200	0.107000	7.03e-01	0.345000
Signaling by WNT	188	2.41e-02	1.26e-01	0.11500	-0.074000	0.088200	8.17e-02	0.038000
Muscle contraction	133	7.14e-02	2.37e-01	0.11500	-0.093900	0.066200	6.22e-02	0.189000
MET activates PTK2 signaling	16	7.27e-01	8.44e-01	0.11500	-0.106000	0.043500	4.62e-01	0.763000
SUMOylation of DNA methylation proteins	15	7.43e-01	8.48e-01	0.11400	-0.043400	0.106000	7.71e-01	0.478000
Immune System	1332	9.66e-11	2.69e-08	0.11400	0.111000	-0.027300	5.00e-11	0.107000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	25	6.17e-01	7.66e-01	0.11400	-0.110000	-0.030100	3.41e-01	0.794000
Platelet homeostasis	63	2.90e-01	4.98e-01	0.11400	0.089400	-0.070500	2.20e-01	0.334000
Signaling by NOTCH	133	8.01e-02	2.56e-01	0.11300	-0.022200	-0.111000	6.60e-01	0.027100
Nucleotide salvage	16	7.36e-01	8.46e-01	0.11300	-0.018800	-0.112000	8.96e-01	0.439000
Nuclear Events (kinase and transcription factor activation)	49	3.87e-01	5.87e-01	0.11300	-0.106000	0.039200	1.99e-01	0.635000
TBC/RABGAPs	33	5.36e-01	7.08e-01	0.11300	-0.089500	-0.069400	3.74e-01	0.491000
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	12	7.94e-01	8.84e-01	0.11300	-0.010000	0.113000	9.52e-01	0.499000
mRNA decay by 3' to 5' exoribonuclease	10	8.25e-01	8.95e-01	0.11300	0.109000	-0.028500	5.50e-01	0.876000
Signaling by Interleukins	298	4.39e-03	4.02e-02	0.11200	0.098100	0.055000	3.82e-03	0.105000
Macroautophagy	80	2.28e-01	4.42e-01	0.11200	-0.047000	-0.102000	4.68e-01	0.116000
Signaling by the B Cell Receptor (BCR)	78	2.41e-01	4.55e-01	0.11100	-0.054600	-0.097100	4.06e-01	0.139000
SHC-mediated cascade:FGFR2	11	8.18e-01	8.95e-01	0.11100	-0.065000	-0.090300	7.09e-01	0.604000
Metabolism of nucleotides	70	2.72e-01	4.83e-01	0.11100	0.096900	-0.054100	1.62e-01	0.434000
Cell surface interactions at the vascular wall	93	1.81e-01	3.93e-01	0.11100	0.097100	-0.052800	1.06e-01	0.380000
Voltage gated Potassium channels	21	6.86e-01	8.20e-01	0.11000	-0.102000	-0.041200	4.19e-01	0.744000
Activation of NMDA receptors and postsynaptic events	54	3.80e-01	5.79e-01	0.10900	-0.109000	0.010400	1.67e-01	0.895000
rRNA modification in the nucleus and cytosol	42	4.73e-01	6.58e-01	0.10900	-0.108000	-0.016200	2.25e-01	0.856000
Defective B4GALT7 causes EDS, progeroid type	14	7.81e-01	8.72e-01	0.10900	-0.070700	-0.083500	6.47e-01	0.589000
Chaperonin-mediated protein folding	62	3.38e-01	5.49e-01	0.10900	0.060100	0.091100	4.14e-01	0.216000
Interleukin receptor SHC signaling	18	7.24e-01	8.42e-01	0.10900	-0.038600	0.102000	7.77e-01	0.454000
MyD88-independent TLR4 cascade	76	2.58e-01	4.69e-01	0.10900	-0.104000	0.031800	1.17e-01	0.632000
TRIF(TICAM1)-mediated TLR4 signaling	76	2.58e-01	4.69e-01	0.10900	-0.104000	0.031800	1.17e-01	0.632000
rRNA processing	103	1.66e-01	3.74e-01	0.10900	0.043300	0.099900	4.49e-01	0.080400
Signaling by BMP	21	6.88e-01	8.21e-01	0.10900	0.021400	-0.107000	8.65e-01	0.398000
Blood group systems biosynthesis	12	8.10e-01	8.95e-01	0.10900	0.102000	0.036900	5.40e-01	0.825000
Transmission across Chemical Synapses	152	6.90e-02	2.31e-01	0.10900	-0.104000	0.030200	2.69e-02	0.522000
Spry regulation of FGF signaling	10	8.37e-01	8.98e-01	0.10900	0.020000	-0.107000	9.13e-01	0.559000
Influenza Infection	67	3.17e-01	5.24e-01	0.10800	-0.064900	-0.086400	3.59e-01	0.222000
Interleukin-2 family signaling	29	5.99e-01	7.55e-01	0.10800	-0.083000	0.069100	4.40e-01	0.520000
Regulation of APC/C activators between G1/S and early anaphase	56	3.73e-01	5.74e-01	0.10800	0.057100	-0.091600	4.61e-01	0.236000
Golgi Associated Vesicle Biogenesis	37	5.27e-01	6.98e-01	0.10700	0.024500	-0.104000	7.97e-01	0.272000
RHO GTPases Activate WASPs and WAVEs	30	5.92e-01	7.50e-01	0.10700	0.087800	-0.061600	4.05e-01	0.560000
ERKs are inactivated	12	8.16e-01	8.95e-01	0.10700	0.043800	0.097700	7.93e-01	0.558000
Reproduction	50	4.39e-01	6.28e-01	0.10600	-0.065100	-0.083400	4.26e-01	0.308000
AKT phosphorylates targets in the cytosol	12	8.17e-01	8.95e-01	0.10600	-0.103000	0.024500	5.38e-01	0.883000
Sema3A PAK dependent Axon repulsion	12	8.22e-01	8.95e-01	0.10500	0.078400	0.070200	6.38e-01	0.674000
Anti-inflammatory response favouring Leishmania parasite infection	94	2.12e-01	4.25e-01	0.10500	0.105000	-0.007080	7.92e-02	0.906000
Leishmania parasite growth and survival	94	2.12e-01	4.25e-01	0.10500	0.105000	-0.007080	7.92e-02	0.906000
Oncogenic MAPK signaling	55	4.05e-01	6.04e-01	0.10500	-0.024200	-0.102000	7.57e-01	0.189000
Signaling by high-kinase activity BRAF mutants	22	6.91e-01	8.22e-01	0.10500	0.085100	-0.061900	4.90e-01	0.616000
Adenylate cyclase inhibitory pathway	12	8.22e-01	8.95e-01	0.10500	0.035300	0.098900	8.33e-01	0.553000
Organelle biogenesis and maintenance	199	4.15e-02	1.73e-01	0.10500	-0.089200	-0.055200	3.08e-02	0.182000
Diseases of metabolism	162	7.27e-02	2.40e-01	0.10500	0.105000	0.002540	2.21e-02	0.956000
Cyclin D associated events in G1	31	6.07e-01	7.61e-01	0.10500	-0.084700	-0.061200	4.15e-01	0.556000
G1 Phase	31	6.07e-01	7.61e-01	0.10500	-0.084700	-0.061200	4.15e-01	0.556000
Platelet Aggregation (Plug Formation)	28	6.40e-01	7.81e-01	0.10400	0.049800	0.091200	6.49e-01	0.404000
Signaling by Activin	10	8.50e-01	9.03e-01	0.10400	-0.057600	0.086100	7.53e-01	0.637000
Signaling by PDGFR in disease	17	7.58e-01	8.58e-01	0.10400	-0.067000	0.079000	6.33e-01	0.573000
APC/C-mediated degradation of cell cycle proteins	63	3.65e-01	5.72e-01	0.10300	0.008480	-0.103000	9.07e-01	0.158000
Regulation of mitotic cell cycle	63	3.65e-01	5.72e-01	0.10300	0.008480	-0.103000	9.07e-01	0.158000
SLC-mediated transmembrane transport	156	8.31e-02	2.61e-01	0.10300	-0.073600	0.072200	1.14e-01	0.121000
HCMV Infection	58	4.05e-01	6.04e-01	0.10300	-0.080800	-0.063800	2.88e-01	0.402000
HCMV Late Events	36	5.68e-01	7.33e-01	0.10300	-0.099700	-0.025400	3.01e-01	0.792000
Cell-Cell communication	76	3.02e-01	5.09e-01	0.10300	0.002160	-0.103000	9.74e-01	0.122000
Signaling by VEGF	88	2.56e-01	4.69e-01	0.10300	-0.070400	-0.074800	2.55e-01	0.226000
Sialic acid metabolism	23	7.00e-01	8.29e-01	0.10200	0.044000	0.092500	7.15e-01	0.443000
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	23	6.97e-01	8.28e-01	0.10200	0.097400	-0.030300	4.19e-01	0.801000
Potential therapeutics for SARS	26	6.70e-01	8.09e-01	0.10200	-0.023500	-0.099000	8.36e-01	0.382000
STING mediated induction of host immune responses	10	8.59e-01	9.07e-01	0.10100	0.094700	0.035800	6.04e-01	0.845000
Defects in vitamin and cofactor metabolism	14	8.08e-01	8.93e-01	0.10100	-0.025400	-0.098000	8.69e-01	0.526000
Diseases of glycosylation	103	2.08e-01	4.25e-01	0.10100	0.101000	-0.010500	7.85e-02	0.855000
The NLRP3 inflammasome	11	8.44e-01	9.01e-01	0.10100	0.054200	-0.085100	7.56e-01	0.625000
Peroxisomal lipid metabolism	22	7.13e-01	8.38e-01	0.10100	0.033500	-0.095100	7.86e-01	0.440000
Signaling by PDGFRA extracellular domain mutants	10	8.59e-01	9.07e-01	0.10100	-0.101000	0.005260	5.82e-01	0.977000
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	10	8.59e-01	9.07e-01	0.10100	-0.101000	0.005260	5.82e-01	0.977000
Complex I biogenesis	35	5.92e-01	7.50e-01	0.10000	0.099600	0.011100	3.08e-01	0.909000
TCR signaling	79	3.13e-01	5.19e-01	0.10000	-0.050500	-0.086400	4.39e-01	0.185000
RNA Polymerase III Transcription Initiation From Type 1 Promoter	17	7.73e-01	8.66e-01	0.09980	0.068700	-0.072400	6.24e-01	0.606000
Metabolism of porphyrins	20	7.47e-01	8.49e-01	0.09940	0.066300	0.074000	6.08e-01	0.567000
Autophagy	90	2.69e-01	4.82e-01	0.09930	-0.025800	-0.095900	6.72e-01	0.117000
Intracellular signaling by second messengers	224	3.90e-02	1.67e-01	0.09910	-0.098700	0.009310	1.13e-02	0.811000
Signaling by TGFB family members	68	3.75e-01	5.74e-01	0.09900	-0.090000	-0.041300	2.00e-01	0.557000
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	20	7.47e-01	8.49e-01	0.09880	-0.098300	-0.010800	4.47e-01	0.934000
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	41	5.47e-01	7.16e-01	0.09860	-0.073600	0.065500	4.15e-01	0.468000
Netrin-1 signaling	40	5.58e-01	7.28e-01	0.09820	-0.083700	0.051300	3.60e-01	0.575000
VEGFA-VEGFR2 Pathway	83	3.10e-01	5.17e-01	0.09810	-0.079100	-0.058000	2.14e-01	0.362000
HS-GAG biosynthesis	18	7.72e-01	8.66e-01	0.09760	0.031600	-0.092300	8.17e-01	0.498000
Acyl chain remodelling of PG	13	8.34e-01	8.98e-01	0.09730	0.055200	0.080100	7.30e-01	0.617000
RA biosynthesis pathway	12	8.45e-01	9.01e-01	0.09720	0.021600	0.094700	8.97e-01	0.570000
E3 ubiquitin ligases ubiquitinate target proteins	22	7.30e-01	8.45e-01	0.09710	-0.083900	0.048800	4.96e-01	0.692000
G alpha (12/13) signalling events	61	4.27e-01	6.21e-01	0.09700	0.094500	0.021700	2.02e-01	0.769000
Post-translational modification: synthesis of GPI-anchored proteins	50	5.03e-01	6.83e-01	0.09660	0.047200	0.084300	5.64e-01	0.303000
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	12	8.44e-01	9.01e-01	0.09640	-0.048400	0.083300	7.71e-01	0.617000
G alpha (s) signalling events	78	3.46e-01	5.55e-01	0.09620	0.054900	0.079000	4.03e-01	0.228000
Signaling by Hedgehog	91	2.89e-01	4.97e-01	0.09620	0.091800	0.028600	1.31e-01	0.638000
Amino acids regulate mTORC1	33	6.35e-01	7.78e-01	0.09560	0.026400	-0.091900	7.93e-01	0.361000
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	20	7.63e-01	8.61e-01	0.09550	-0.091100	-0.028800	4.81e-01	0.824000
Downstream TCR signaling	62	4.36e-01	6.27e-01	0.09540	-0.057200	-0.076400	4.37e-01	0.299000
Defective B3GAT3 causes JDSSDHD	14	8.29e-01	8.96e-01	0.09480	-0.093600	-0.014900	5.44e-01	0.923000
Intrinsic Pathway for Apoptosis	41	5.73e-01	7.38e-01	0.09470	0.067500	-0.066300	4.55e-01	0.463000
Opioid Signalling	67	4.09e-01	6.05e-01	0.09450	-0.006350	0.094300	9.29e-01	0.183000
Transport of bile salts and organic acids, metal ions and amine compounds	52	4.97e-01	6.79e-01	0.09430	-0.049600	0.080200	5.37e-01	0.318000
Uptake and function of anthrax toxins	11	8.65e-01	9.12e-01	0.09420	-0.012500	-0.093300	9.43e-01	0.592000
Defective B3GALT6 causes EDSP2 and SEMDJL1	13	8.42e-01	9.01e-01	0.09410	-0.092500	-0.017200	5.64e-01	0.915000
O-glycosylation of TSR domain-containing proteins	30	6.77e-01	8.14e-01	0.09400	0.073200	0.058900	4.88e-01	0.577000
Frs2-mediated activation	10	8.74e-01	9.16e-01	0.09390	-0.059900	0.072400	7.43e-01	0.692000
RNA Polymerase I Promoter Escape	16	8.12e-01	8.95e-01	0.09380	-0.047200	-0.081000	7.44e-01	0.575000
Signaling by SCF-KIT	34	6.41e-01	7.81e-01	0.09350	-0.006350	0.093300	9.49e-01	0.347000
RHO GTPases activate PKNs	27	7.04e-01	8.30e-01	0.09320	-0.093100	0.004130	4.03e-01	0.970000
MET promotes cell motility	26	7.18e-01	8.39e-01	0.09300	0.055200	0.074900	6.26e-01	0.509000
MAP2K and MAPK activation	24	7.30e-01	8.45e-01	0.09300	0.077000	-0.052200	5.14e-01	0.658000
Rab regulation of trafficking	90	3.18e-01	5.25e-01	0.09300	-0.086000	-0.035300	1.59e-01	0.564000
Defective B3GALTL causes Peters-plus syndrome (PpS)	29	6.92e-01	8.22e-01	0.09290	0.069000	0.062200	5.21e-01	0.562000
Apoptosis	126	2.00e-01	4.17e-01	0.09280	0.001310	-0.092800	9.80e-01	0.073000
Interleukin-37 signaling	15	8.26e-01	8.95e-01	0.09180	-0.042900	0.081100	7.74e-01	0.587000
Signaling by BRAF and RAF fusions	43	5.81e-01	7.47e-01	0.09130	0.056500	-0.071700	5.22e-01	0.416000
Neurexins and neuroligins	37	6.30e-01	7.76e-01	0.09100	-0.036000	0.083500	7.05e-01	0.380000
Negative regulation of FGFR1 signaling	16	8.23e-01	8.95e-01	0.09090	-0.075300	-0.050900	6.02e-01	0.725000
IKK complex recruitment mediated by RIP1	15	8.32e-01	8.97e-01	0.09000	-0.077900	0.045100	6.01e-01	0.763000
NCAM signaling for neurite out-growth	44	5.84e-01	7.48e-01	0.08990	-0.039700	0.080700	6.49e-01	0.355000
PI Metabolism	68	4.38e-01	6.28e-01	0.08980	-0.083700	0.032600	2.34e-01	0.643000
Negative regulation of FGFR3 signaling	16	8.28e-01	8.96e-01	0.08930	-0.042700	-0.078500	7.68e-01	0.587000
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	4.30e-01	6.21e-01	0.08870	-0.071200	0.052800	3.00e-01	0.442000
Toll Like Receptor 2 (TLR2) Cascade	71	4.30e-01	6.21e-01	0.08870	-0.071200	0.052800	3.00e-01	0.442000
Toll Like Receptor TLR1:TLR2 Cascade	71	4.30e-01	6.21e-01	0.08870	-0.071200	0.052800	3.00e-01	0.442000
Toll Like Receptor TLR6:TLR2 Cascade	71	4.30e-01	6.21e-01	0.08870	-0.071200	0.052800	3.00e-01	0.442000
Prefoldin mediated transfer of substrate to CCT/TriC	19	8.02e-01	8.90e-01	0.08840	-0.082200	-0.032500	5.35e-01	0.806000
Metabolism of amino acids and derivatives	196	1.03e-01	2.93e-01	0.08840	0.086200	-0.019800	3.84e-02	0.634000
Assembly and cell surface presentation of NMDA receptors	17	8.18e-01	8.95e-01	0.08830	0.056200	-0.068100	6.88e-01	0.627000
Stimuli-sensing channels	55	5.25e-01	6.97e-01	0.08820	0.030300	-0.082900	6.98e-01	0.288000
Phospholipid metabolism	151	1.74e-01	3.85e-01	0.08810	-0.086300	0.018000	6.82e-02	0.704000
Potassium Channels	50	5.60e-01	7.29e-01	0.08800	0.087000	-0.013100	2.88e-01	0.873000
Glycerophospholipid biosynthesis	83	3.87e-01	5.87e-01	0.08760	-0.087400	0.005740	1.70e-01	0.928000
PIP3 activates AKT signaling	191	1.19e-01	3.14e-01	0.08740	-0.083400	-0.026300	4.79e-02	0.532000
ERK/MAPK targets	20	7.95e-01	8.84e-01	0.08740	-0.085700	0.017200	5.07e-01	0.894000
Metalloprotease DUBs	15	8.42e-01	9.01e-01	0.08710	0.080700	-0.032700	5.89e-01	0.826000
Keratinization	26	7.47e-01	8.49e-01	0.08710	-0.038300	-0.078200	7.35e-01	0.491000
Cargo recognition for clathrin-mediated endocytosis	64	4.91e-01	6.76e-01	0.08670	-0.023800	-0.083400	7.43e-01	0.250000
Interleukin-1 family signaling	94	3.48e-01	5.57e-01	0.08660	0.083400	-0.023000	1.63e-01	0.700000
ADORA2B mediated anti-inflammatory cytokines production	63	5.01e-01	6.83e-01	0.08640	0.071300	0.048700	3.28e-01	0.504000
SARS-CoV-1 Infection	29	7.30e-01	8.45e-01	0.08560	0.082300	0.023400	4.43e-01	0.827000
Signaling by NODAL	15	8.48e-01	9.02e-01	0.08550	-0.021200	0.082800	8.87e-01	0.579000
Cell-cell junction organization	27	7.42e-01	8.47e-01	0.08550	0.046500	-0.071700	6.76e-01	0.519000
Vitamin B5 (pantothenate) metabolism	12	8.79e-01	9.19e-01	0.08540	-0.073400	-0.043700	6.60e-01	0.793000
RAB GEFs exchange GTP for GDP on RABs	63	5.14e-01	6.90e-01	0.08430	-0.083700	-0.009620	2.51e-01	0.895000
Cytokine Signaling in Immune system	554	3.94e-03	3.82e-02	0.08390	0.083200	0.010800	9.46e-04	0.669000
Signaling by RAF1 mutants	26	7.62e-01	8.61e-01	0.08330	0.081800	-0.016000	4.71e-01	0.888000
PTEN Regulation	99	3.66e-01	5.72e-01	0.08330	-0.058500	-0.059300	3.16e-01	0.309000
NR1H2 and NR1H3-mediated signaling	35	6.99e-01	8.29e-01	0.08330	0.072000	0.041800	4.61e-01	0.669000
Dectin-2 family	10	9.00e-01	9.35e-01	0.08320	0.071200	-0.043000	6.97e-01	0.814000
Tight junction interactions	12	8.85e-01	9.23e-01	0.08270	0.076600	0.031300	6.46e-01	0.851000
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	9.03e-01	9.35e-01	0.08250	-0.082400	0.000625	6.52e-01	0.997000
Defective EXT2 causes exostoses 2	10	9.03e-01	9.35e-01	0.08250	-0.082400	0.000625	6.52e-01	0.997000
Free fatty acids regulate insulin secretion	11	8.96e-01	9.32e-01	0.08210	-0.068800	-0.044700	6.93e-01	0.797000
Programmed Cell Death	129	2.77e-01	4.89e-01	0.08180	0.011500	-0.081000	8.23e-01	0.113000
Infection with Mycobacterium tuberculosis	20	8.17e-01	8.95e-01	0.08150	-0.068900	0.043700	5.94e-01	0.735000
Signaling by Rho GTPases	288	6.25e-02	2.21e-01	0.08150	-0.077800	-0.024300	2.40e-02	0.481000
Ephrin signaling	17	8.45e-01	9.01e-01	0.08100	-0.021700	0.078100	8.77e-01	0.578000
Metabolism of steroids	97	3.94e-01	5.96e-01	0.08060	-0.079400	-0.013600	1.78e-01	0.817000
TP53 Regulates Metabolic Genes	58	5.68e-01	7.33e-01	0.08050	-0.077500	0.021900	3.08e-01	0.774000
C-type lectin receptors (CLRs)	89	4.29e-01	6.21e-01	0.08040	-0.036900	-0.071400	5.48e-01	0.245000
Adrenaline,noradrenaline inhibits insulin secretion	19	8.35e-01	8.98e-01	0.08010	0.047400	0.064500	7.21e-01	0.626000
Signaling by NTRK1 (TRKA)	94	4.06e-01	6.04e-01	0.07990	-0.076200	0.024200	2.03e-01	0.686000
Resolution of Abasic Sites (AP sites)	29	7.57e-01	8.58e-01	0.07970	-0.074900	0.027100	4.85e-01	0.801000
Formation of TC-NER Pre-Incision Complex	31	7.56e-01	8.57e-01	0.07810	-0.027300	-0.073200	7.93e-01	0.481000
DAP12 signaling	20	8.32e-01	8.97e-01	0.07800	0.025800	-0.073600	8.42e-01	0.569000
Regulation of KIT signaling	10	9.14e-01	9.39e-01	0.07790	0.050800	0.059100	7.81e-01	0.746000
Interleukin-1 signaling	70	5.33e-01	7.06e-01	0.07720	0.070300	-0.031800	3.10e-01	0.646000
Cellular responses to external stimuli	318	6.65e-02	2.27e-01	0.07700	-0.067200	-0.037500	4.08e-02	0.253000
Keratan sulfate/keratin metabolism	21	8.34e-01	8.98e-01	0.07640	0.041100	0.064400	7.44e-01	0.610000
Interleukin-15 signaling	11	9.08e-01	9.35e-01	0.07590	-0.035900	0.066900	8.37e-01	0.701000
Metabolism of RNA	424	3.08e-02	1.43e-01	0.07580	-0.070300	-0.028500	1.40e-02	0.320000
Post-chaperonin tubulin folding pathway	16	8.72e-01	9.16e-01	0.07520	0.073300	-0.016900	6.12e-01	0.907000
NCAM1 interactions	27	7.95e-01	8.84e-01	0.07510	-0.015400	0.073500	8.90e-01	0.509000
Sphingolipid de novo biosynthesis	27	8.00e-01	8.88e-01	0.07400	0.069300	-0.025900	5.33e-01	0.816000
Non-integrin membrane-ECM interactions	35	7.49e-01	8.51e-01	0.07370	-0.050600	0.053600	6.05e-01	0.583000
Elastic fibre formation	31	7.83e-01	8.73e-01	0.07320	0.043100	0.059200	6.78e-01	0.569000
UCH proteinases	59	6.20e-01	7.68e-01	0.07310	-0.052800	0.050600	4.83e-01	0.502000
PI3K/AKT Signaling in Cancer	74	5.55e-01	7.26e-01	0.07310	-0.072900	-0.005490	2.79e-01	0.935000
Cyclin A:Cdk2-associated events at S phase entry	56	6.41e-01	7.81e-01	0.07300	0.001480	-0.073000	9.85e-01	0.346000
Transcriptional Regulation by VENTX	32	7.78e-01	8.70e-01	0.07290	-0.062600	-0.037300	5.40e-01	0.715000
Long-term potentiation	17	8.73e-01	9.16e-01	0.07280	0.021500	-0.069500	8.78e-01	0.620000
Amyloid fiber formation	29	8.06e-01	8.93e-01	0.07090	0.053800	0.046300	6.17e-01	0.666000
Regulation of RUNX1 Expression and Activity	14	9.01e-01	9.35e-01	0.07000	-0.057900	0.039200	7.07e-01	0.800000
Hemostasis	396	6.06e-02	2.17e-01	0.06960	0.064200	-0.027000	2.99e-02	0.361000
Sealing of the nuclear envelope (NE) by ESCRT-III	19	8.70e-01	9.16e-01	0.06950	0.038700	-0.057700	7.71e-01	0.663000
RNA Polymerase III Transcription Initiation From Type 2 Promoter	16	8.89e-01	9.25e-01	0.06940	0.038500	-0.057800	7.90e-01	0.689000
Activation of BH3-only proteins	26	8.30e-01	8.96e-01	0.06920	-0.001460	-0.069200	9.90e-01	0.542000
Cellular responses to stress	314	1.20e-01	3.16e-01	0.06840	-0.062900	-0.026900	5.70e-02	0.416000
HDACs deacetylate histones	22	8.59e-01	9.07e-01	0.06770	-0.064900	0.019100	5.98e-01	0.877000
Adaptive Immune System	499	3.95e-02	1.69e-01	0.06680	0.029600	-0.059900	2.63e-01	0.023500
tRNA processing	75	6.12e-01	7.64e-01	0.06680	-0.051700	-0.042200	4.39e-01	0.528000
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	8.25e-01	8.95e-01	0.06620	0.029400	-0.059300	7.84e-01	0.580000
Signaling by RAS mutants	29	8.25e-01	8.95e-01	0.06620	0.029400	-0.059300	7.84e-01	0.580000
Signaling by moderate kinase activity BRAF mutants	29	8.25e-01	8.95e-01	0.06620	0.029400	-0.059300	7.84e-01	0.580000
Signaling downstream of RAS mutants	29	8.25e-01	8.95e-01	0.06620	0.029400	-0.059300	7.84e-01	0.580000
Regulation of mRNA stability by proteins that bind AU-rich elements	59	6.85e-01	8.19e-01	0.06610	-0.036100	-0.055300	6.32e-01	0.463000
Platelet sensitization by LDL	14	9.13e-01	9.39e-01	0.06580	0.008320	-0.065300	9.57e-01	0.672000
Neuronal System	225	2.38e-01	4.52e-01	0.06560	-0.061000	0.024200	1.17e-01	0.534000
NOTCH3 Intracellular Domain Regulates Transcription	21	8.75e-01	9.16e-01	0.06480	0.037500	-0.052800	7.66e-01	0.675000
Antigen processing: Ubiquitination & Proteasome degradation	212	2.75e-01	4.87e-01	0.06480	-0.052700	-0.037700	1.88e-01	0.346000
Diseases of signal transduction by growth factor receptors and second messengers	269	2.00e-01	4.17e-01	0.06400	-0.063500	-0.008400	7.49e-02	0.814000
Clathrin-mediated endocytosis	95	5.60e-01	7.29e-01	0.06380	0.015600	-0.061900	7.94e-01	0.298000
p75 NTR receptor-mediated signalling	73	6.46e-01	7.86e-01	0.06380	0.058400	0.025700	3.89e-01	0.704000
tRNA modification in the nucleus and cytosol	28	8.48e-01	9.02e-01	0.06290	0.062300	0.008470	5.68e-01	0.938000
Respiratory electron transport	57	7.17e-01	8.39e-01	0.06260	0.062500	-0.001360	4.15e-01	0.986000
Cell death signalling via NRAGE, NRIF and NADE	59	7.13e-01	8.38e-01	0.06240	0.028600	0.055500	7.05e-01	0.462000
Vesicle-mediated transport	455	8.17e-02	2.59e-01	0.06190	-0.001800	-0.061900	9.48e-01	0.025200
Unblocking of NMDA receptors, glutamate binding and activation	14	9.23e-01	9.44e-01	0.06170	0.016900	-0.059300	9.13e-01	0.701000
Cell junction organization	49	7.63e-01	8.61e-01	0.06110	-0.021400	-0.057200	7.95e-01	0.489000
Cyclin E associated events during G1/S transition	54	7.38e-01	8.46e-01	0.06100	0.030500	-0.052900	6.99e-01	0.502000
Membrane Trafficking	429	1.02e-01	2.93e-01	0.06100	-0.016800	-0.058600	5.54e-01	0.039400
cGMP effects	13	9.32e-01	9.50e-01	0.06080	0.038500	0.047000	8.10e-01	0.769000
Association of TriC/CCT with target proteins during biosynthesis	29	8.53e-01	9.06e-01	0.06070	0.011700	0.059600	9.13e-01	0.579000
Nicotinate metabolism	18	9.07e-01	9.35e-01	0.06060	-0.036900	-0.048000	7.86e-01	0.724000
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	62	7.15e-01	8.38e-01	0.06050	0.057800	0.017800	4.32e-01	0.808000
Cilium Assembly	139	4.75e-01	6.59e-01	0.06040	-0.015800	-0.058300	7.49e-01	0.237000
Fc epsilon receptor (FCERI) signaling	95	5.96e-01	7.53e-01	0.06020	-0.055700	0.022800	3.49e-01	0.702000
Transport to the Golgi and subsequent modification	120	5.43e-01	7.14e-01	0.05860	0.058500	0.003600	2.70e-01	0.946000
Integrin signaling	20	9.05e-01	9.35e-01	0.05790	0.010700	0.056900	9.34e-01	0.660000
ER to Golgi Anterograde Transport	100	6.06e-01	7.61e-01	0.05770	0.047400	-0.032900	4.14e-01	0.570000
Assembly of collagen fibrils and other multimeric structures	36	8.36e-01	8.98e-01	0.05730	0.053100	-0.021800	5.82e-01	0.821000
Negative regulation of the PI3K/AKT network	80	6.78e-01	8.14e-01	0.05730	-0.056400	-0.010300	3.84e-01	0.874000
Inflammasomes	16	9.25e-01	9.44e-01	0.05730	0.003600	0.057200	9.80e-01	0.692000
Infectious disease	451	1.17e-01	3.12e-01	0.05730	0.012500	-0.055900	6.54e-01	0.044100
Unfolded Protein Response (UPR)	65	7.29e-01	8.45e-01	0.05710	0.000148	0.057100	9.98e-01	0.427000
Peroxisomal protein import	45	8.03e-01	8.90e-01	0.05680	0.031500	-0.047300	7.15e-01	0.584000
Disorders of transmembrane transporters	109	5.93e-01	7.50e-01	0.05680	-0.056700	0.002880	3.08e-01	0.959000
Peptide hormone metabolism	46	8.08e-01	8.93e-01	0.05590	0.054900	0.010300	5.20e-01	0.904000
Insulin receptor recycling	12	9.45e-01	9.59e-01	0.05580	0.050200	-0.024400	7.63e-01	0.884000
Signaling by Receptor Tyrosine Kinases	356	2.19e-01	4.32e-01	0.05460	-0.025400	-0.048300	4.14e-01	0.120000
Neurotransmitter receptors and postsynaptic signal transmission	114	6.14e-01	7.64e-01	0.05370	-0.053600	-0.004090	3.24e-01	0.940000
Transcriptional regulation of granulopoiesis	29	8.84e-01	9.23e-01	0.05360	0.015900	0.051200	8.82e-01	0.634000
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	76	7.23e-01	8.42e-01	0.05360	-0.053200	-0.006170	4.23e-01	0.926000
Ion channel transport	97	6.59e-01	7.98e-01	0.05340	0.038600	-0.036800	5.12e-01	0.532000
COPII-mediated vesicle transport	47	8.23e-01	8.95e-01	0.05310	0.044700	0.028600	5.96e-01	0.735000
NRAGE signals death through JNK	51	8.10e-01	8.95e-01	0.05290	0.038100	0.036700	6.38e-01	0.650000
RAS processing	11	9.56e-01	9.67e-01	0.05240	0.031400	0.042000	8.57e-01	0.810000
Platelet calcium homeostasis	20	9.23e-01	9.44e-01	0.05190	-0.045500	-0.024900	7.25e-01	0.847000
Ion transport by P-type ATPases	34	8.74e-01	9.16e-01	0.05170	0.041800	0.030400	6.73e-01	0.759000
COPI-mediated anterograde transport	64	7.74e-01	8.66e-01	0.05150	0.046600	-0.022100	5.20e-01	0.761000
Diseases associated with O-glycosylation of proteins	45	8.37e-01	8.98e-01	0.05110	0.040300	-0.031400	6.41e-01	0.716000
Interconversion of nucleotide di- and triphosphates	22	9.19e-01	9.43e-01	0.05090	0.014500	0.048800	9.07e-01	0.692000
Metabolism of lipids	484	1.73e-01	3.84e-01	0.05060	-0.043900	-0.025200	1.02e-01	0.349000
Mitochondrial Fatty Acid Beta-Oxidation	25	9.08e-01	9.35e-01	0.05040	0.031300	-0.039500	7.87e-01	0.732000
Protein-protein interactions at synapses	53	8.18e-01	8.95e-01	0.05020	0.049800	-0.006850	5.31e-01	0.931000
Signaling by NTRKs	107	6.69e-01	8.09e-01	0.04990	-0.030500	0.039500	5.86e-01	0.482000
Signaling by GPCR	420	2.34e-01	4.50e-01	0.04930	0.042400	0.025200	1.40e-01	0.381000
RNA Polymerase III Transcription Initiation	23	9.20e-01	9.43e-01	0.04920	0.005370	-0.048900	9.64e-01	0.685000
Negative regulation of FGFR4 signaling	16	9.45e-01	9.59e-01	0.04890	-0.036500	-0.032400	8.00e-01	0.822000
G alpha (i) signalling events	199	5.05e-01	6.84e-01	0.04820	0.048000	-0.004230	2.45e-01	0.919000
Diseases associated with glycosaminoglycan metabolism	30	9.05e-01	9.35e-01	0.04750	-0.025300	-0.040300	8.11e-01	0.703000
SARS-CoV Infections	55	8.30e-01	8.96e-01	0.04740	0.032400	-0.034600	6.78e-01	0.658000
Class I MHC mediated antigen processing & presentation	252	4.69e-01	6.56e-01	0.04510	0.009890	-0.044000	7.88e-01	0.232000
O-linked glycosylation of mucins	34	9.02e-01	9.35e-01	0.04500	0.044500	0.007020	6.54e-01	0.944000
Axon guidance	360	3.49e-01	5.57e-01	0.04500	0.044500	0.007150	1.51e-01	0.817000
Toll Like Receptor 4 (TLR4) Cascade	97	7.46e-01	8.49e-01	0.04480	-0.025100	0.037100	6.71e-01	0.528000
O-linked glycosylation	68	8.21e-01	8.95e-01	0.04440	0.041000	0.017200	5.60e-01	0.807000
GPVI-mediated activation cascade	25	9.34e-01	9.50e-01	0.04230	0.028700	-0.031200	8.04e-01	0.787000
IRE1alpha activates chaperones	39	9.08e-01	9.35e-01	0.04070	0.040700	0.000184	6.60e-01	0.998000
RNA Polymerase III Transcription Initiation From Type 3 Promoter	19	9.55e-01	9.67e-01	0.04020	0.015400	0.037200	9.08e-01	0.779000
MECP2 regulates neuronal receptors and channels	11	9.73e-01	9.84e-01	0.04020	-0.034500	0.020500	8.43e-01	0.906000
Death Receptor Signalling	108	7.73e-01	8.66e-01	0.04010	-0.000654	-0.040100	9.91e-01	0.473000
MAPK family signaling cascades	213	6.06e-01	7.61e-01	0.03980	-0.037500	0.013300	3.47e-01	0.740000
Visual phototransduction	55	8.78e-01	9.19e-01	0.03950	-0.022100	0.032700	7.77e-01	0.675000
G alpha (q) signalling events	119	7.61e-01	8.61e-01	0.03940	0.039000	0.005340	4.63e-01	0.920000
Transcriptional regulation by RUNX3	74	8.46e-01	9.01e-01	0.03930	-0.022900	-0.031900	7.33e-01	0.636000
Signal Transduction	1520	6.21e-02	2.21e-01	0.03770	-0.037600	-0.001000	1.84e-02	0.950000
L1CAM interactions	78	8.55e-01	9.07e-01	0.03690	0.014500	0.033900	8.25e-01	0.605000
ECM proteoglycans	42	9.19e-01	9.43e-01	0.03650	0.022100	-0.029000	8.04e-01	0.745000
Beta-catenin independent WNT signaling	104	8.19e-01	8.95e-01	0.03620	0.030600	0.019300	5.91e-01	0.734000
Metabolism of fat-soluble vitamins	25	9.53e-01	9.66e-01	0.03610	0.021500	0.029000	8.53e-01	0.802000
Retinoid metabolism and transport	24	9.55e-01	9.67e-01	0.03570	0.034900	-0.007610	7.68e-01	0.949000
XBP1(S) activates chaperone genes	38	9.30e-01	9.50e-01	0.03550	0.035100	-0.005850	7.09e-01	0.950000
Rho GTPase cycle	111	8.13e-01	8.95e-01	0.03550	0.005510	0.035100	9.20e-01	0.524000
FCERI mediated NF-kB activation	53	9.05e-01	9.35e-01	0.03520	0.028500	-0.020600	7.20e-01	0.796000
Aggrephagy	15	9.77e-01	9.86e-01	0.03230	0.015300	-0.028400	9.18e-01	0.849000
Toll-like Receptor Cascades	108	8.54e-01	9.06e-01	0.03160	0.026700	0.016800	6.32e-01	0.764000
Transcriptional regulation by RUNX1	132	8.56e-01	9.07e-01	0.02840	-0.024300	-0.014700	6.31e-01	0.771000
Base-Excision Repair, AP Site Formation	16	9.81e-01	9.88e-01	0.02840	0.026800	0.009370	8.53e-01	0.948000
Degradation of beta-catenin by the destruction complex	59	9.33e-01	9.50e-01	0.02800	-0.006690	0.027200	9.29e-01	0.718000
Post-translational protein modification	894	3.98e-01	6.00e-01	0.02750	-0.024900	-0.011700	2.17e-01	0.562000
Nervous system development	380	6.77e-01	8.14e-01	0.02670	0.026200	0.005250	3.85e-01	0.862000
GPCR downstream signalling	388	7.20e-01	8.40e-01	0.02430	0.024000	0.003530	4.21e-01	0.906000
Neddylation	159	8.75e-01	9.16e-01	0.02400	-0.013400	-0.020000	7.72e-01	0.665000
Metabolism of water-soluble vitamins and cofactors	83	9.33e-01	9.50e-01	0.02380	-0.023300	-0.004940	7.15e-01	0.938000
Transport of small molecules	449	7.00e-01	8.29e-01	0.02350	0.023200	0.003760	4.04e-01	0.892000
Metabolism of proteins	1221	4.47e-01	6.36e-01	0.02220	0.021600	-0.005150	2.19e-01	0.769000
FLT3 Signaling	192	8.82e-01	9.21e-01	0.02120	-0.018800	-0.009900	6.55e-01	0.814000
RNA Polymerase III Abortive And Retractive Initiation	27	9.82e-01	9.88e-01	0.02120	0.018500	-0.010400	8.68e-01	0.926000
RNA Polymerase III Transcription	27	9.82e-01	9.88e-01	0.02120	0.018500	-0.010400	8.68e-01	0.926000
Metabolism of vitamins and cofactors	124	9.23e-01	9.44e-01	0.02080	0.001320	-0.020800	9.80e-01	0.691000
Metabolism of carbohydrates	196	8.86e-01	9.23e-01	0.02040	-0.005480	0.019600	8.95e-01	0.637000
Molecules associated with elastic fibres	26	9.87e-01	9.91e-01	0.01860	0.018600	-0.001140	8.70e-01	0.992000
Disease	947	7.23e-01	8.42e-01	0.01580	0.000463	-0.015800	9.81e-01	0.421000
Influenza Viral RNA Transcription and Replication	55	9.80e-01	9.88e-01	0.01570	0.000260	-0.015700	9.97e-01	0.841000
RAF/MAP kinase cascade	179	9.41e-01	9.56e-01	0.01530	-0.005500	-0.014300	9.00e-01	0.743000
MAPK6/MAPK4 signaling	61	9.83e-01	9.89e-01	0.01380	-0.009490	-0.010000	8.98e-01	0.893000
Negative regulation of FGFR2 signaling	18	9.95e-01	9.99e-01	0.01300	-0.011400	-0.006280	9.33e-01	0.963000
Developmental Biology	590	8.87e-01	9.23e-01	0.01210	-0.009710	-0.007200	6.91e-01	0.768000
Metabolism	1314	8.71e-01	9.16e-01	0.00898	-0.007010	-0.005610	6.80e-01	0.741000
COPI-independent Golgi-to-ER retrograde traffic	26	9.97e-01	9.99e-01	0.00885	-0.001930	-0.008640	9.86e-01	0.939000
MAPK1/MAPK3 signaling	184	9.91e-01	9.95e-01	0.00580	-0.004960	-0.003010	9.08e-01	0.944000
Constitutive Signaling by Aberrant PI3K in Cancer	52	9.99e-01	1.00e+00	0.00351	-0.001140	0.003320	9.89e-01	0.967000
Cytosolic sensors of pathogen-associated DNA	44	1.00e+00	1.00e+00	0.00199	0.001630	-0.001150	9.85e-01	0.990000
Fatty acid metabolism	113	9.99e-01	1.00e+00	0.00188	0.001710	-0.000784	9.75e-01	0.989000

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Detailed Gene set reports

Classical antibody-mediated complement activation

Classical antibody-mediated complement activation

metric	value
setSize	10
pMANOVA	1.44e-06
p.adjustMANOVA	0.000111
s.dist	0.942
s.rna	0.864
s.meth	-0.375
p.rna	2.25e-06
p.meth	0.0399

Top 20 genes

Gene	rna	meth
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
C1S	4756.0	-5268.0
C1QA	4762.0	-2623.0

Click HERE to show all gene set members

All member genes

	rna	meth
C1QA	4762.0	-2623.0
C1QB	4709.0	2019.0
C1QC	4706.0	1820.0
C1R	4790.0	3315.0
C1S	4756.0	-5268.0
CRP	92.0	1763.0
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5

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FCGR activation

FCGR activation

metric	value
setSize	15
pMANOVA	3.17e-05
p.adjustMANOVA	0.00135
s.dist	0.675
s.rna	0.626
s.meth	-0.253
p.rna	2.71e-05
p.meth	0.0894

Top 20 genes

Gene	rna	meth
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
FCGR1A	4880.5	-2267.5
FCGR3A	4289.5	-1522.5
FCGR2A	4804.5	-559.5

Click HERE to show all gene set members

All member genes

	rna	meth
CD247	-3041.0	-1250.0
CD3G	-1843.0	-5162.0
FCGR1A	4880.5	-2267.5
FCGR2A	4804.5	-559.5
FCGR3A	4289.5	-1522.5
FGR	4893.0	1178.0
FYN	3781.0	4472.0
HCK	4684.0	4743.0
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
LYN	3729.0	3514.0
SRC	1543.0	37.0
SYK	-2067.0	-2681.0

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Creation of C4 and C2 activators

Creation of C4 and C2 activators

metric	value
setSize	14
pMANOVA	7.72e-05
p.adjustMANOVA	0.00251
s.dist	0.669
s.rna	0.643
s.meth	-0.185
p.rna	3.13e-05
p.meth	0.23

Top 20 genes

Gene	rna	meth
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
C1S	4756.0	-5268.0
C1QA	4762.0	-2623.0

Click HERE to show all gene set members

All member genes

	rna	meth
C1QA	4762.0	-2623.0
C1QB	4709.0	2019.0
C1QC	4706.0	1820.0
C1R	4790.0	3315.0
C1S	4756.0	-5268.0
COLEC11	-4522.0	2591.0
CRP	92.0	1763.0
FCN1	4667.5	2881.5
FCN2	4667.5	2881.5
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
MASP2	-4639.0	-2270.0

---

---

Initial triggering of complement

Initial triggering of complement

metric	value
setSize	20
pMANOVA	2.62e-06
p.adjustMANOVA	0.00018
s.dist	0.653
s.rna	0.638
s.meth	-0.139
p.rna	7.95e-07
p.meth	0.281

Top 20 genes

Gene	rna	meth
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
C1S	4756.0	-5268.0
C1QA	4762.0	-2623.0
CFB	4968.0	-1500.0
GZMM	1715.0	-1717.0
C4A	4270.5	-159.5
C4B	4270.5	-159.5

Click HERE to show all gene set members

All member genes

	rna	meth
C1QA	4762.0	-2623.0
C1QB	4709.0	2019.0
C1QC	4706.0	1820.0
C1R	4790.0	3315.0
C1S	4756.0	-5268.0
C3	4447.0	2762.0
C4A	4270.5	-159.5
C4B	4270.5	-159.5
CFB	4968.0	-1500.0
CFD	-1974.0	-597.0
COLEC11	-4522.0	2591.0
CRP	92.0	1763.0
FCN1	4667.5	2881.5
FCN2	4667.5	2881.5
GZMM	1715.0	-1717.0
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
MASP2	-4639.0	-2270.0

---

---

Digestion

Digestion

metric	value
setSize	12
pMANOVA	0.000574
p.adjustMANOVA	0.0104
s.dist	0.643
s.rna	-0.636
s.meth	0.095
p.rna	0.000138
p.meth	0.569

Top 20 genes

Gene	rna	meth
AMY1A	-5886	2030
AMY1B	-5886	2030
AMY2A	-5886	2030
AMY2B	-5886	2030
PNLIP	-4572	2595
CEL	-5190	2121
ALPI	-4258	875

Click HERE to show all gene set members

All member genes

	rna	meth
ALPI	-4258	875
AMY1A	-5886	2030
AMY1B	-5886	2030
AMY2A	-5886	2030
AMY2B	-5886	2030
CEL	-5190	2121
GUCY2C	-3712	-3323
LCT	-1089	-1917
MGAM	2795	4665
PIR	-3172	-5077
PNLIP	-4572	2595
PNLIPRP2	-4070	-2517

---

---

Na+/Cl- dependent neurotransmitter transporters

Na+/Cl- dependent neurotransmitter transporters

metric	value
setSize	11
pMANOVA	0.00137
p.adjustMANOVA	0.0195
s.dist	0.63
s.rna	-0.617
s.meth	0.129
p.rna	0.000395
p.meth	0.46

Top 20 genes

Gene	rna	meth
SLC6A5	-4073	5342
SLC6A18	-3495	4856
SLC6A20	-5506	2600
SLC6A19	-5643	1612
SLC6A12	-2283	1417
SLC6A3	-497	5127
SLC6A9	-4422	217

Click HERE to show all gene set members

All member genes

	rna	meth
SLC18A1	-3637	-3049
SLC6A1	-3139	-4366
SLC6A12	-2283	1417
SLC6A13	-3986	-3507
SLC6A18	-3495	4856
SLC6A19	-5643	1612
SLC6A2	-5122	-3150
SLC6A20	-5506	2600
SLC6A3	-497	5127
SLC6A5	-4073	5342
SLC6A9	-4422	217

---

---

Digestion and absorption

Digestion and absorption

metric	value
setSize	13
pMANOVA	0.000745
p.adjustMANOVA	0.0126
s.dist	0.606
s.rna	-0.593
s.meth	0.127
p.rna	0.000216
p.meth	0.428

Top 20 genes

Gene	rna	meth
AMY1A	-5886	2030
AMY1B	-5886	2030
AMY2A	-5886	2030
AMY2B	-5886	2030
PNLIP	-4572	2595
CEL	-5190	2121
ALPI	-4258	875
RSC1A1	-856	2715

Click HERE to show all gene set members

All member genes

	rna	meth
ALPI	-4258	875
AMY1A	-5886	2030
AMY1B	-5886	2030
AMY2A	-5886	2030
AMY2B	-5886	2030
CEL	-5190	2121
GUCY2C	-3712	-3323
LCT	-1089	-1917
MGAM	2795	4665
PIR	-3172	-5077
PNLIP	-4572	2595
PNLIPRP2	-4070	-2517
RSC1A1	-856	2715

---

---

Cholesterol biosynthesis

Cholesterol biosynthesis

metric	value
setSize	16
pMANOVA	0.000356
p.adjustMANOVA	0.00758
s.dist	0.576
s.rna	-0.575
s.meth	-0.0364
p.rna	6.87e-05
p.meth	0.801

Top 20 genes

Gene	rna	meth
IDI1	-5099	-5403
SC5D	-5734	-4150
CYP51A1	-5577	-3758
HSD17B7	-5347	-3464
MVD	-3434	-5230
SQLE	-4829	-1293

Click HERE to show all gene set members

All member genes

	rna	meth
ACAT2	-5257	264
CYP51A1	-5577	-3758
DHCR7	-4164	1916
EBP	-1370	155
HMGCR	-5286	2638
HSD17B7	-5347	-3464
IDI1	-5099	-5403
LBR	-5325	762
LSS	-5152	4198
MSMO1	-2262	2091
MVD	-3434	-5230
MVK	1078	-504
NSDHL	-82	3333
PMVK	726	4400
SC5D	-5734	-4150
SQLE	-4829	-1293

---

---

Signal regulatory protein family interactions

Signal regulatory protein family interactions

metric	value
setSize	11
pMANOVA	0.00399
p.adjustMANOVA	0.0384
s.dist	0.574
s.rna	0.427
s.meth	-0.384
p.rna	0.0141
p.meth	0.0275

Top 20 genes

Gene	rna	meth
SIRPA	4996.5	-5486.5
SIRPB1	4996.5	-5486.5
SIRPG	4996.5	-5486.5
TYROBP	4922.0	-3748.0
CD47	453.0	-5043.0

Click HERE to show all gene set members

All member genes

	rna	meth
CD47	453.0	-5043.0
FYB	3244.0	327.0
GRB2	-473.0	779.0
PTK2B	-1155.0	2783.0
PTPN11	-1608.0	671.0
PTPN6	-1241.0	-2911.0
SIRPA	4996.5	-5486.5
SIRPB1	4996.5	-5486.5
SIRPG	4996.5	-5486.5
SRC	1543.0	37.0
TYROBP	4922.0	-3748.0

---

---

GABA synthesis, release, reuptake and degradation

GABA synthesis, release, reuptake and degradation

metric	value
setSize	11
pMANOVA	0.00732
p.adjustMANOVA	0.059
s.dist	0.545
s.rna	-0.543
s.meth	0.049
p.rna	0.00182
p.meth	0.778

Top 20 genes

Gene	rna	meth
VAMP2	-5651	5020
STXBP1	-3677	5323
SYT1	-3465	1805
SLC6A12	-2283	1417
ABAT	-1765	943
STX1A	-5644	1

Click HERE to show all gene set members

All member genes

	rna	meth
ABAT	-1765	943
DNAJC5	-3443	-2346
GAD1	-4566	-5359
RAB3A	234	3398
SLC6A1	-3139	-4366
SLC6A12	-2283	1417
SLC6A13	-3986	-3507
STX1A	-5644	1
STXBP1	-3677	5323
SYT1	-3465	1805
VAMP2	-5651	5020

---

---

Regulation of IFNA signaling

Regulation of IFNA signaling

metric	value
setSize	10
pMANOVA	0.0131
p.adjustMANOVA	0.0873
s.dist	0.541
s.rna	0.455
s.meth	0.293
p.rna	0.0126
p.meth	0.109

Top 20 genes

Gene	rna	meth
IFNAR1	3453	4760
IFNAR2	3167	4919
SOCS3	3427	4458
PTPN1	4114	3669
STAT1	4872	1657
TYK2	1555	3375

Click HERE to show all gene set members

All member genes

	rna	meth
IFNAR1	3453.0	4760.0
IFNAR2	3167.0	4919.0
JAK1	-1732.0	-2624.0
PTPN1	4114.0	3669.0
PTPN11	-1608.0	671.0
PTPN6	-1241.0	-2911.0
SOCS3	3427.0	4458.0
STAT1	4872.0	1657.0
TYK2	1555.0	3375.0
USP18	4314.5	-2599.5

---

---

eNOS activation

eNOS activation

metric	value
setSize	10
pMANOVA	0.012
p.adjustMANOVA	0.0824
s.dist	0.541
s.rna	0.161
s.meth	-0.516
p.rna	0.378
p.meth	0.00471

Top 20 genes

Gene	rna	meth
DDAH2	3950	-3073
LYPLA1	2766	-3830
SPR	1407	-5292
AKT1	1966	-2627
CALM1	4109	-1048

Click HERE to show all gene set members

All member genes

	rna	meth
AKT1	1966	-2627
CALM1	4109	-1048
CAV1	-1374	1024
DDAH1	-982	-3584
DDAH2	3950	-3073
HSP90AA1	-5228	-3496
LYPLA1	2766	-3830
NOS3	-1032	-2784
SPR	1407	-5292
ZDHHC21	-1282	-3915

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	42
pMANOVA	2e-08
p.adjustMANOVA	2.24e-06
s.dist	0.533
s.rna	0.517
s.meth	0.131
p.rna	6.94e-09
p.meth	0.143

Top 20 genes

Gene	rna	meth
RPL11	4947	4590
SRP14	3515	5383
DDOST	4339	4274
RPN1	3732	4954
RPL5	4018	4289
RPS6	3227	5175
RPL14	3462	4737
FAU	2589	3679
SRP68	3037	2896
SPCS3	4711	1741
SSR2	4383	1803
SRP19	1825	4150
RPS26	2095	1982
RPL7	2654	904
RPL8	1104	2033
RPL22L1	514	1840
SEC11C	2493	298
RPS24	524	854
RPL22	3173	79

Click HERE to show all gene set members

All member genes

	rna	meth
DDOST	4339	4274
FAU	2589	3679
RPL10	4285	-603
RPL11	4947	4590
RPL14	3462	4737
RPL15	-1395	3435
RPL22	3173	79
RPL22L1	514	1840
RPL23A	-1535	-4465
RPL26	3817	-3274
RPL28	4231	-19
RPL3	4185	-622
RPL31	4356	-3320
RPL34	3150	-981
RPL37	3516	-1820
RPL3L	-5817	1945
RPL5	4018	4289
RPL7	2654	904
RPL8	1104	2033
RPN1	3732	4954
RPN2	3851	-2199
RPS14	3259	-156
RPS19	1113	-2067
RPS24	524	854
RPS26	2095	1982
RPS27	-178	4461
RPS6	3227	5175
RPS9	4095	-3291
SEC11A	2266	-4417
SEC11C	2493	298
SEC61A1	3098	-2809
SEC61A2	-155	730
SEC61G	3355	-4715
SPCS3	4711	1741
SRP14	3515	5383
SRP19	1825	4150
SRP68	3037	2896
SRP72	3261	-2406
SRP9	3275	-1801
SRPRB	-56	-4144
SSR2	4383	1803
TRAM1	-3337	4356

---

---

Regulation of Complement cascade

Regulation of Complement cascade

metric	value
setSize	30
pMANOVA	2.8e-06
p.adjustMANOVA	0.000182
s.dist	0.531
s.rna	0.49
s.meth	-0.203
p.rna	3.4e-06
p.meth	0.0541

Top 20 genes

Gene	rna	meth
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
C1S	4756.0	-5268.0
C5AR1	4082.0	-5269.0
C3AR1	4379.0	-4325.0
C1QA	4762.0	-2623.0
ELANE	4276.0	-1898.0
C5AR2	4151.0	-1868.0
CFB	4968.0	-1500.0
CFH	1330.0	-3812.0
PROS1	3990.0	-1201.0
SERPING1	1442.0	-1364.0
C4A	4270.5	-159.5
C4B	4270.5	-159.5

Click HERE to show all gene set members

All member genes

	rna	meth
C1QA	4762.0	-2623.0
C1QB	4709.0	2019.0
C1QC	4706.0	1820.0
C1R	4790.0	3315.0
C1S	4756.0	-5268.0
C3	4447.0	2762.0
C3AR1	4379.0	-4325.0
C4A	4270.5	-159.5
C4B	4270.5	-159.5
C4BPA	-35.0	-1828.0
C5AR1	4082.0	-5269.0
C5AR2	4151.0	-1868.0
C6	4730.0	736.0
C7	-601.0	1543.0
C8A	-1303.0	-924.0
CD19	-3459.0	-4357.0
CD46	-5693.0	4177.0
CD59	-5657.0	1751.0
CD81	532.0	2333.0
CFB	4968.0	-1500.0
CFH	1330.0	-3812.0
CLU	-1368.0	3166.0
ELANE	4276.0	-1898.0
F2	-4706.0	159.0
IGHG1	4675.5	-5496.5
IGHG2	4675.5	-5496.5
IGHG3	4675.5	-5496.5
IGHG4	4675.5	-5496.5
PROS1	3990.0	-1201.0
SERPING1	1442.0	-1364.0

---

---

Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)

metric	value
setSize	13
pMANOVA	0.00429
p.adjustMANOVA	0.04
s.dist	0.531
s.rna	-0.519
s.meth	-0.112
p.rna	0.0012
p.meth	0.486

Top 20 genes

Gene	rna	meth
IDH3B	-5403	-4515
CS	-5536	-3752
IDH2	-3697	-2793
SUCLG1	-3788	-907
FH	-980	-3412
ACO2	-5330	-477
IDH3G	-295	-4712
SDHB	-241	-3782

Click HERE to show all gene set members

All member genes

	rna	meth
ACO2	-5330	-477
CS	-5536	-3752
DLD	-3310	1693
FH	-980	-3412
IDH2	-3697	-2793
IDH3B	-5403	-4515
IDH3G	-295	-4712
ME3	-3414	4724
NNT	-1961	3672
SDHA	-4395	2792
SDHB	-241	-3782
SUCLA2	-4100	2862
SUCLG1	-3788	-907

---

---

Metabolism of nitric oxide: NOS3 activation and regulation

Metabolism of nitric oxide: NOS3 activation and regulation

metric	value
setSize	14
pMANOVA	0.00261
p.adjustMANOVA	0.0315
s.dist	0.53
s.rna	0.169
s.meth	-0.502
p.rna	0.272
p.meth	0.00114

Top 20 genes

Gene	rna	meth
DDAH2	3950	-3073
LYPLA1	2766	-3830
SPR	1407	-5292
AKT1	1966	-2627
NOSIP	2214	-2298
CALM1	4109	-1048

Click HERE to show all gene set members

All member genes

	rna	meth
AKT1	1966	-2627
CALM1	4109	-1048
CAV1	-1374	1024
DDAH1	-982	-3584
DDAH2	3950	-3073
DNM2	-2111	-4215
HSP90AA1	-5228	-3496
LYPLA1	2766	-3830
NOS3	-1032	-2784
NOSIP	2214	-2298
NOSTRIN	4865	1063
SPR	1407	-5292
WASL	-2600	-4918
ZDHHC21	-1282	-3915

---

---

Retrograde neurotrophin signalling

Retrograde neurotrophin signalling

metric	value
setSize	12
pMANOVA	0.00651
p.adjustMANOVA	0.0538
s.dist	0.526
s.rna	0.214
s.meth	-0.481
p.rna	0.2
p.meth	0.00394

Top 20 genes

Gene	rna	meth
DNAL4	4490	-4664
CLTA	3782	-5203
DNM1	4133	-2989
AP2S1	2436	-991
AP2M1	187	-761

Click HERE to show all gene set members

All member genes

	rna	meth
AP2A1	-1009	-1979
AP2A2	-1955	-4657
AP2M1	187	-761
AP2S1	2436	-991
CLTA	3782	-5203
CLTC	-3233	-3408
DNAL4	4490	-4664
DNM1	4133	-2989
DNM2	-2111	-4215
DNM3	2019	3618
NGF	-89	-3123
SH3GL2	-54	-3658

---

---

HDMs demethylate histones

HDMs demethylate histones

metric	value
setSize	15
pMANOVA	0.00219
p.adjustMANOVA	0.0279
s.dist	0.521
s.rna	-0.521
s.meth	0.0261
p.rna	0.000479
p.meth	0.861

Top 20 genes

Gene	rna	meth
KDM5A	-4230	5014
KDM4B	-2279	3298
MINA	-2200	2699
KDM5B	-4871	1010
KDM1B	-2627	1790
KDM2B	-4711	823
PHF8	-217	3622

Click HERE to show all gene set members

All member genes

	rna	meth
KDM1A	-2853	-2747
KDM1B	-2627	1790
KDM2A	-5014	-2610
KDM2B	-4711	823
KDM4A	-1451	-1108
KDM4B	-2279	3298
KDM4C	327	4467
KDM5A	-4230	5014
KDM5B	-4871	1010
KDM5C	-4777	-3832
KDM5D	-4911	-4332
KDM6B	-4668	-1361
MINA	-2200	2699
PHF8	-217	3622
UTY	-4662	-5430

---

---

HIV elongation arrest and recovery

HIV elongation arrest and recovery

metric	value
setSize	15
pMANOVA	0.00351
p.adjustMANOVA	0.0349
s.dist	0.505
s.rna	-0.374
s.meth	-0.34
p.rna	0.0122
p.meth	0.0226

Top 20 genes

Gene	rna	meth
POLR2A	-5023	-5380
SUPT5H	-4713	-4662
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
CCNT1	-5574	-2529
POLR2B	-3789	-1748
SSRP1	-963	-3529
CDK9	-501	-4835

Click HERE to show all gene set members

All member genes

	rna	meth
CCNT1	-5574	-2529
CDK9	-501	-4835
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
NELFB	-2730	5138
NELFCD	-2082	272
NELFE	4200	1192
POLR2A	-5023	-5380
POLR2B	-3789	-1748
POLR2C	-3436	342
POLR2E	1685	-3734
SSRP1	-963	-3529
SUPT4H1	-781	3534
SUPT5H	-4713	-4662

---

---

Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation

metric	value
setSize	15
pMANOVA	0.00351
p.adjustMANOVA	0.0349
s.dist	0.505
s.rna	-0.374
s.meth	-0.34
p.rna	0.0122
p.meth	0.0226

Top 20 genes

Gene	rna	meth
POLR2A	-5023	-5380
SUPT5H	-4713	-4662
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
CCNT1	-5574	-2529
POLR2B	-3789	-1748
SSRP1	-963	-3529
CDK9	-501	-4835

Click HERE to show all gene set members

All member genes

	rna	meth
CCNT1	-5574	-2529
CDK9	-501	-4835
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
NELFB	-2730	5138
NELFCD	-2082	272
NELFE	4200	1192
POLR2A	-5023	-5380
POLR2B	-3789	-1748
POLR2C	-3436	342
POLR2E	1685	-3734
SSRP1	-963	-3529
SUPT4H1	-781	3534
SUPT5H	-4713	-4662

---

---

Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation

metric	value
setSize	15
pMANOVA	0.00351
p.adjustMANOVA	0.0349
s.dist	0.505
s.rna	-0.374
s.meth	-0.34
p.rna	0.0122
p.meth	0.0226

Top 20 genes

Gene	rna	meth
POLR2A	-5023	-5380
SUPT5H	-4713	-4662
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
CCNT1	-5574	-2529
POLR2B	-3789	-1748
SSRP1	-963	-3529
CDK9	-501	-4835

Click HERE to show all gene set members

All member genes

	rna	meth
CCNT1	-5574	-2529
CDK9	-501	-4835
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
NELFB	-2730	5138
NELFCD	-2082	272
NELFE	4200	1192
POLR2A	-5023	-5380
POLR2B	-3789	-1748
POLR2C	-3436	342
POLR2E	1685	-3734
SSRP1	-963	-3529
SUPT4H1	-781	3534
SUPT5H	-4713	-4662

---

---

Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery

metric	value
setSize	15
pMANOVA	0.00351
p.adjustMANOVA	0.0349
s.dist	0.505
s.rna	-0.374
s.meth	-0.34
p.rna	0.0122
p.meth	0.0226

Top 20 genes

Gene	rna	meth
POLR2A	-5023	-5380
SUPT5H	-4713	-4662
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
CCNT1	-5574	-2529
POLR2B	-3789	-1748
SSRP1	-963	-3529
CDK9	-501	-4835

Click HERE to show all gene set members

All member genes

	rna	meth
CCNT1	-5574	-2529
CDK9	-501	-4835
CTDP1	-5143	-4000
ELL	-4933	-3868
GTF2F1	-3364	-4749
NELFB	-2730	5138
NELFCD	-2082	272
NELFE	4200	1192
POLR2A	-5023	-5380
POLR2B	-3789	-1748
POLR2C	-3436	342
POLR2E	1685	-3734
SSRP1	-963	-3529
SUPT4H1	-781	3534
SUPT5H	-4713	-4662

---

---

Regulation of FZD by ubiquitination

Regulation of FZD by ubiquitination

metric	value
setSize	11
pMANOVA	0.0145
p.adjustMANOVA	0.0948
s.dist	0.504
s.rna	-0.242
s.meth	0.442
p.rna	0.164
p.meth	0.0112

Top 20 genes

Gene	rna	meth
ZNRF3	-5318	4125
RNF43	-4842	4437
FZD5	-3687	4315
FZD4	-2210	1799
LGR5	-4717	745
LRP6	-2303	400

Click HERE to show all gene set members

All member genes

	rna	meth
FZD4	-2210.0	1799.0
FZD5	-3687.0	4315.0
FZD8	1618.0	4683.0
LGR4	2534.0	-1458.0
LGR5	-4717.0	745.0
LGR6	-4404.0	-1536.0
LRP5	1954.5	4568.5
LRP6	-2303.0	400.0
RNF43	-4842.0	4437.0
RSPO1	1992.0	3728.0
ZNRF3	-5318.0	4125.0

---

---

NS1 Mediated Effects on Host Pathways

NS1 Mediated Effects on Host Pathways

metric	value
setSize	25
pMANOVA	8.97e-05
p.adjustMANOVA	0.00284
s.dist	0.501
s.rna	-0.477
s.meth	-0.152
p.rna	3.61e-05
p.meth	0.188

Top 20 genes

Gene	rna	meth
NUP210	-5538	-4937
NUP155	-4984	-4426
KPNA1	-4424	-4690
KPNB1	-3905	-5224
KPNA3	-4114	-4231
NUP205	-4111	-3973
RAE1	-4574	-3358
KPNA2	-2517	-5213
AAAS	-3404	-2882
TPR	-4118	-1199
NUP85	-4237	-987
NDC1	-274	-4427

Click HERE to show all gene set members

All member genes

	rna	meth
AAAS	-3404.0	-2882.0
CPSF4	-4511.0	2241.0
KPNA1	-4424.0	-4690.0
KPNA2	-2517.0	-5213.0
KPNA3	-4114.0	-4231.0
KPNB1	-3905.0	-5224.0
NDC1	-274.0	-4427.0
NUP107	389.0	2346.0
NUP133	-3872.0	2337.0
NUP153	-4958.0	2844.0
NUP155	-4984.0	-4426.0
NUP160	-5275.0	2064.0
NUP188	-4815.5	4873.5
NUP205	-4111.0	-3973.0
NUP210	-5538.0	-4937.0
NUP214	-2799.0	2906.0
NUP35	136.0	-4440.0
NUP43	-4918.0	526.0
NUP54	-1730.0	16.0
NUP85	-4237.0	-987.0
NUP88	215.0	1566.0
NUP93	-314.0	2592.0
RAE1	-4574.0	-3358.0
SEC13	2708.0	3637.0
TPR	-4118.0	-1199.0

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	27
pMANOVA	4.43e-05
p.adjustMANOVA	0.00166
s.dist	0.5
s.rna	0.467
s.meth	0.181
p.rna	2.71e-05
p.meth	0.104

Top 20 genes

Gene	rna	meth
RPL11	4947	4590
RPL5	4018	4289
RPS6	3227	5175
RPL14	3462	4737
FAU	2589	3679
EEF1A1	1932	2247
RPS26	2095	1982
RPL7	2654	904
RPL8	1104	2033
RPL22L1	514	1840
RPS24	524	854
RPL22	3173	79

Click HERE to show all gene set members

All member genes

	rna	meth
EEF1A1	1932	2247
EEF2	-908	3366
FAU	2589	3679
RPL10	4285	-603
RPL11	4947	4590
RPL14	3462	4737
RPL15	-1395	3435
RPL22	3173	79
RPL22L1	514	1840
RPL23A	-1535	-4465
RPL26	3817	-3274
RPL28	4231	-19
RPL3	4185	-622
RPL31	4356	-3320
RPL34	3150	-981
RPL37	3516	-1820
RPL3L	-5817	1945
RPL5	4018	4289
RPL7	2654	904
RPL8	1104	2033
RPS14	3259	-156
RPS19	1113	-2067
RPS24	524	854
RPS26	2095	1982
RPS27	-178	4461
RPS6	3227	5175
RPS9	4095	-3291

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	27
pMANOVA	5.58e-05
p.adjustMANOVA	0.00196
s.dist	0.494
s.rna	0.478
s.meth	0.123
p.rna	1.69e-05
p.meth	0.269

Top 20 genes

Gene	rna	meth
RPL11	4947	4590
RPL5	4018	4289
RPS6	3227	5175
RPL14	3462	4737
FAU	2589	3679
RPS26	2095	1982
GRSF1	1464	2420
RPL7	2654	904
RPL8	1104	2033
RPL22L1	514	1840
RPS24	524	854
RPL22	3173	79

Click HERE to show all gene set members

All member genes

	rna	meth
DNAJC3	1277	-5273
FAU	2589	3679
GRSF1	1464	2420
RPL10	4285	-603
RPL11	4947	4590
RPL14	3462	4737
RPL15	-1395	3435
RPL22	3173	79
RPL22L1	514	1840
RPL23A	-1535	-4465
RPL26	3817	-3274
RPL28	4231	-19
RPL3	4185	-622
RPL31	4356	-3320
RPL34	3150	-981
RPL37	3516	-1820
RPL3L	-5817	1945
RPL5	4018	4289
RPL7	2654	904
RPL8	1104	2033
RPS14	3259	-156
RPS19	1113	-2067
RPS24	524	854
RPS26	2095	1982
RPS27	-178	4461
RPS6	3227	5175
RPS9	4095	-3291

---

---

Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases

metric	value
setSize	18
pMANOVA	0.00131
p.adjustMANOVA	0.0192
s.dist	0.494
s.rna	0.472
s.meth	-0.146
p.rna	0.000529
p.meth	0.284

Top 20 genes

Gene	rna	meth
CTSG	4689	-5438
MMP8	4691	-4970
MMP16	1899	-5448
ELANE	4276	-1898
COL18A1	2991	-2443
CTSV	4760	-1390
MMP25	4066	-1516
MMP9	3119	-644
FURIN	208	-2726
MMP2	1886	-293

Click HERE to show all gene set members

All member genes

	rna	meth
CMA1	2758	52
COL18A1	2991	-2443
CTSG	4689	-5438
CTSK	3571	985
CTSV	4760	-1390
ELANE	4276	-1898
FURIN	208	-2726
MMP11	-956	4521
MMP14	3804	1708
MMP15	-2104	1944
MMP16	1899	-5448
MMP17	-649	-3392
MMP2	1886	-293
MMP25	4066	-1516
MMP8	4691	-4970
MMP9	3119	-644
TIMP2	3524	469
TPSAB1	-4380	5217

---

---

Downregulation of SMAD2/3:SMAD4 transcriptional activity

Downregulation of SMAD2/3:SMAD4 transcriptional activity

metric	value
setSize	14
pMANOVA	0.0059
p.adjustMANOVA	0.0512
s.dist	0.493
s.rna	-0.473
s.meth	0.137
p.rna	0.00218
p.meth	0.374

Top 20 genes

Gene	rna	meth
TGIF1	-4792	5358
SKIL	-4605	3911
SKI	-3754	4279
SMAD3	-4598	845
NCOR2	-3799	509
TGIF2	-408	3848
PARP1	-2489	626
SMAD2	-1080	1372
UBE2D1	-3100	465
NCOR1	-826	279

Click HERE to show all gene set members

All member genes

	rna	meth
NCOR1	-826	279
NCOR2	-3799	509
NEDD4L	-2326	-4730
PARP1	-2489	626
SKI	-3754	4279
SKIL	-4605	3911
SMAD2	-1080	1372
SMAD3	-4598	845
SMAD4	-3140	-1428
SMURF2	-2926	-2936
TGIF1	-4792	5358
TGIF2	-408	3848
UBE2D1	-3100	465
USP9X	-4396	-2718

---

---

Activation of gene expression by SREBF (SREBP)

Activation of gene expression by SREBF (SREBP)

metric	value
setSize	35
pMANOVA	4.11e-06
p.adjustMANOVA	0.000242
s.dist	0.488
s.rna	-0.475
s.meth	-0.114
p.rna	1.18e-06
p.meth	0.243

Top 20 genes

Gene	rna	meth
IDI1	-5099	-5403
MTF1	-4868	-5182
SC5D	-5734	-4150
CYP51A1	-5577	-3758
MVD	-3434	-5230
GPAM	-3021	-5353
ELOVL6	-5672	-2802
HELZ2	-5338	-2672
CARM1	-3244	-4252
FASN	-5469	-1757
SQLE	-4829	-1293
CREBBP	-3931	-1157
ACACB	-2832	-1586
PPARA	-4989	-872
CHD9	-3626	-810
TGS1	-917	-2698
SREBF2	-5680	-271
NCOA1	-388	-3456
NFYC	-3143	-383

Click HERE to show all gene set members

All member genes

	rna	meth
ACACA	-5677	1788
ACACB	-2832	-1586
CARM1	-3244	-4252
CHD9	-3626	-810
CREBBP	-3931	-1157
CYP51A1	-5577	-3758
DHCR7	-4164	1916
ELOVL6	-5672	-2802
FASN	-5469	-1757
GPAM	-3021	-5353
HELZ2	-5338	-2672
HMGCR	-5286	2638
IDI1	-5099	-5403
LSS	-5152	4198
MED1	-4704	205
MTF1	-4868	-5182
MVD	-3434	-5230
MVK	1078	-504
NCOA1	-388	-3456
NCOA2	-2785	321
NCOA6	-2660	1975
NFYA	-3271	841
NFYB	1154	-6
NFYC	-3143	-383
PMVK	726	4400
PPARA	-4989	-872
RXRA	4566	4649
SC5D	-5734	-4150
SCD	4373	5366
SMARCD3	-1543	1449
SP1	-4940	440
SQLE	-4829	-1293
SREBF1	349	-176
SREBF2	-5680	-271
TGS1	-917	-2698

---

---

Interferon gamma signaling

Interferon gamma signaling

metric	value
setSize	53
pMANOVA	5.09e-09
p.adjustMANOVA	7.84e-07
s.dist	0.488
s.rna	0.447
s.meth	-0.195
p.rna	1.78e-08
p.meth	0.0141

Top 20 genes

Gene	rna	meth
TRIM5	4991.0	-4246.0
GBP5	4550.0	-4092.0
OAS1	4988.0	-3635.0
TRIM6	4714.0	-3219.0
MID1	2454.0	-5140.0
TRIM62	3668.0	-3383.0
IRF8	4287.0	-2797.0
FCGR1A	4880.5	-2267.5
FCGR1B	4880.5	-2267.5
TRIM3	4357.0	-2185.0
PTAFR	3577.0	-2616.0
IRF1	3212.0	-2676.0
IRF9	4102.0	-1956.0
OASL	2964.0	-2516.0
CAMK2A	1915.0	-3892.0
TRIM68	2562.0	-2845.0
IFNG	3047.0	-2290.0
HLA-DQB1	1836.5	-3665.5
HLA-DQB2	1836.5	-3665.5
PRKCD	1516.0	-3959.0

Click HERE to show all gene set members

All member genes

	rna	meth
CAMK2A	1915.0	-3892.0
CAMK2B	-2868.0	1608.0
CAMK2D	1504.0	2815.0
CAMK2G	-3997.0	2895.0
CIITA	3330.0	-426.0
FCGR1A	4880.5	-2267.5
FCGR1B	4880.5	-2267.5
GBP4	4925.5	1514.5
GBP5	4550.0	-4092.0
GBP6	4971.0	191.0
GBP7	4925.5	1514.5
HLA-DQB1	1836.5	-3665.5
HLA-DQB2	1836.5	-3665.5
ICAM1	1881.0	129.0
IFI30	4660.0	1139.0
IFNG	3047.0	-2290.0
IFNGR1	3446.0	-89.0
IFNGR2	-2290.0	-4016.0
IRF1	3212.0	-2676.0
IRF3	-1108.0	-824.0
IRF4	-2952.0	-2042.0
IRF5	-1863.0	-4976.0
IRF6	-4946.0	-3214.0
IRF7	4944.0	4259.0
IRF8	4287.0	-2797.0
IRF9	4102.0	-1956.0
JAK1	-1732.0	-2624.0
MID1	2454.0	-5140.0
OAS1	4988.0	-3635.0
OAS2	4962.0	-404.0
OAS3	-880.0	-876.0
OASL	2964.0	-2516.0
PML	1682.0	-675.0
PRKCD	1516.0	-3959.0
PTAFR	3577.0	-2616.0
PTPN1	4114.0	3669.0
PTPN11	-1608.0	671.0
PTPN2	994.0	-3353.0
PTPN6	-1241.0	-2911.0
SOCS3	3427.0	4458.0
STAT1	4872.0	1657.0
TRIM10	-3077.0	4752.0
TRIM2	-566.0	-4322.0
TRIM21	3327.0	57.0
TRIM26	353.0	4864.0
TRIM3	4357.0	-2185.0
TRIM45	4098.0	2305.0
TRIM46	-3279.0	-4810.0
TRIM5	4991.0	-4246.0
TRIM6	4714.0	-3219.0
TRIM62	3668.0	-3383.0
TRIM68	2562.0	-2845.0
VCAM1	4542.0	1438.0

---

---

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

metric	value
setSize	19
pMANOVA	0.00125
p.adjustMANOVA	0.0185
s.dist	0.488
s.rna	-0.209
s.meth	-0.441
p.rna	0.115
p.meth	0.000888

Top 20 genes

Gene	rna	meth
XRCC3	-4666.0	-4323.0
ATM	-4908.0	-4006.0
RAD51AP1	-4018.0	-4591.0
RMI1	-4402.0	-4041.0
TOP3A	-5038.0	-3402.0
BRCA1	-4027.0	-3935.0
RTEL1	-4002.5	-3626.5
EXO1	-2270.0	-4989.0
BARD1	-2309.0	-4628.0
RAD50	-708.0	-3257.0
DNA2	-1133.0	-1693.0
PALB2	-723.0	-798.0
XRCC2	-128.0	-883.0

Click HERE to show all gene set members

All member genes

	rna	meth
ATM	-4908.0	-4006.0
BARD1	-2309.0	-4628.0
BRCA1	-4027.0	-3935.0
DNA2	-1133.0	-1693.0
EXO1	-2270.0	-4989.0
KAT5	2317.0	-1286.0
PALB2	-723.0	-798.0
RAD50	-708.0	-3257.0
RAD51	-1397.0	1048.0
RAD51AP1	-4018.0	-4591.0
RAD51B	-1424.0	2761.0
RAD51D	3878.0	-4476.0
RBBP8	945.0	-1503.0
RMI1	-4402.0	-4041.0
RMI2	3998.0	1098.0
RTEL1	-4002.5	-3626.5
TOP3A	-5038.0	-3402.0
XRCC2	-128.0	-883.0
XRCC3	-4666.0	-4323.0

---

---

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

metric	value
setSize	14
pMANOVA	0.00654
p.adjustMANOVA	0.0538
s.dist	0.487
s.rna	-0.459
s.meth	0.163
p.rna	0.00294
p.meth	0.29

Top 20 genes

Gene	rna	meth
RGCC	-5356	4167
CNOT6L	-4812	4138
CNOT11	-2734	2867
CNOT3	-4885	1234
RQCD1	-1725	2768
CNOT10	-2978	885
PLK3	-350	4023
CNOT8	-2501	286
CNOT7	-1820	322
TP53	-3550	135

Click HERE to show all gene set members

All member genes

	rna	meth
CNOT10	-2978	885
CNOT11	-2734	2867
CNOT3	-4885	1234
CNOT6	-4209	-3363
CNOT6L	-4812	4138
CNOT7	-1820	322
CNOT8	-2501	286
PLAGL1	2243	-1219
PLK2	-5834	-2220
PLK3	-350	4023
RGCC	-5356	4167
RQCD1	-1725	2768
TNKS1BP1	-2665	-2370
TP53	-3550	135

---

---

Interleukin-35 Signalling

Interleukin-35 Signalling

metric	value
setSize	11
pMANOVA	0.0239
p.adjustMANOVA	0.126
s.dist	0.478
s.rna	0.174
s.meth	0.446
p.rna	0.317
p.meth	0.0105

Top 20 genes

Gene	rna	meth
IL12RB2	2470	5315
STAT1	4872	1657
EBI3	1990	3052
TYK2	1555	3375
IL12A	2124	861
IL6ST	608	2322

Click HERE to show all gene set members

All member genes

	rna	meth
CANX	-754	2138
EBI3	1990	3052
IL12A	2124	861
IL12RB2	2470	5315
IL27RA	-2228	5381
IL6ST	608	2322
JAK1	-1732	-2624
STAT1	4872	1657
STAT3	-102	1420
STAT4	-3277	3152
TYK2	1555	3375

---

---

Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle

metric	value
setSize	35
pMANOVA	7.08e-06
p.adjustMANOVA	0.00038
s.dist	0.478
s.rna	-0.455
s.meth	-0.146
p.rna	3.2e-06
p.meth	0.136

Top 20 genes

Gene	rna	meth
ME1	-5549	-5000
MPC1	-4952	-5207
IDH3B	-5403	-4515
CS	-5536	-3752
PDP2	-5662	-2615
HAGH	-3000	-4735
PDHA1	-5351	-2428
ADHFE1	-5065	-2535
LDHB	-5804	-2172
IDH2	-3697	-2793
VDAC1	-3050	-3145
PDK2	-4418	-2127
SUCLG1	-3788	-907
FH	-980	-3412
ACO2	-5330	-477
D2HGDH	-1442	-1191
IDH3G	-295	-4712
DLAT	-5302	-191
SDHB	-241	-3782
BSG	-3692	-150

Click HERE to show all gene set members

All member genes

	rna	meth
ACO2	-5330	-477
ADHFE1	-5065	-2535
BSG	-3692	-150
CS	-5536	-3752
D2HGDH	-1442	-1191
DLAT	-5302	-191
DLD	-3310	1693
FH	-980	-3412
GLO1	-3065	444
HAGH	-3000	-4735
IDH2	-3697	-2793
IDH3B	-5403	-4515
IDH3G	-295	-4712
LDHA	-1272	4960
LDHB	-5804	-2172
ME1	-5549	-5000
ME3	-3414	4724
MPC1	-4952	-5207
MPC2	-2096	2916
NNT	-1961	3672
PDHA1	-5351	-2428
PDHB	-2454	434
PDK1	1195	-1895
PDK2	-4418	-2127
PDK3	2507	-5387
PDK4	-5524	2168
PDP2	-5662	-2615
PPARD	-3555	4720
RXRA	4566	4649
SDHA	-4395	2792
SDHB	-241	-3782
SLC16A3	3434	-2524
SUCLA2	-4100	2862
SUCLG1	-3788	-907
VDAC1	-3050	-3145

---

---

Antimicrobial peptides

Antimicrobial peptides

metric	value
setSize	21
pMANOVA	0.000761
p.adjustMANOVA	0.0127
s.dist	0.477
s.rna	0.469
s.meth	-0.0843
p.rna	0.000199
p.meth	0.504

Top 20 genes

Gene	rna	meth
CTSG	4689.0	-5438.0
RNASE3	4981.5	-4980.5
RNASE6	4718.0	-4933.0
S100A8	4544.0	-5019.0
SLC11A1	4622.0	-3736.0
ELANE	4276.0	-1898.0
CAMP	4184.0	-1170.0
LTF	4243.0	-779.0

Click HERE to show all gene set members

All member genes

	rna	meth
ATP7A	-2100.0	-972.0
CAMP	4184.0	-1170.0
CCR2	4961.0	2951.0
CCR6	-5198.0	2286.0
CD4	-3112.0	3682.0
CLU	-1368.0	3166.0
CTSG	4689.0	-5438.0
DEFB136	-1373.0	2859.0
ELANE	4276.0	-1898.0
LCN2	4385.0	4586.0
LTF	4243.0	-779.0
LYZ	3889.0	3780.0
PGLYRP1	4751.0	1281.0
PGLYRP2	-4828.0	-5115.0
PRTN3	4219.0	2036.0
RNASE3	4981.5	-4980.5
RNASE6	4718.0	-4933.0
S100A8	4544.0	-5019.0
SLC11A1	4622.0	-3736.0
TLR1	-1042.0	-4612.0
TLR2	4725.0	1254.0

---

---

Common Pathway of Fibrin Clot Formation

Common Pathway of Fibrin Clot Formation

metric	value
setSize	12
pMANOVA	0.0179
p.adjustMANOVA	0.105
s.dist	0.476
s.rna	0.39
s.meth	0.274
p.rna	0.0194
p.meth	0.101

Top 20 genes

Gene	rna	meth
CD177	4181.0	3823.0
SERPINE2	2914.0	3988.0
PROCR	1984.0	4902.0
F10	3965.0	2222.0
PRTN3	4219.0	2036.0
SERPINC1	1259.0	1886.0
THBD	476.0	2158.0
PF4	10.5	1004.5
PF4V1	10.5	1004.5

Click HERE to show all gene set members

All member genes

	rna	meth
CD177	4181.0	3823.0
F10	3965.0	2222.0
F2	-4706.0	159.0
F2R	1790.0	-4771.0
PF4	10.5	1004.5
PF4V1	10.5	1004.5
PROCR	1984.0	4902.0
PROS1	3990.0	-1201.0
PRTN3	4219.0	2036.0
SERPINC1	1259.0	1886.0
SERPINE2	2914.0	3988.0
THBD	476.0	2158.0

---

---

Transport of Ribonucleoproteins into the Host Nucleus

Transport of Ribonucleoproteins into the Host Nucleus

metric	value
setSize	22
pMANOVA	0.000637
p.adjustMANOVA	0.0114
s.dist	0.474
s.rna	-0.46
s.meth	-0.114
p.rna	0.000187
p.meth	0.355

Top 20 genes

Gene	rna	meth
NUP210	-5538	-4937
NUP155	-4984	-4426
KPNA1	-4424	-4690
KPNB1	-3905	-5224
NUP205	-4111	-3973
RAE1	-4574	-3358
AAAS	-3404	-2882
TPR	-4118	-1199
NUP85	-4237	-987
NDC1	-274	-4427

Click HERE to show all gene set members

All member genes

	rna	meth
AAAS	-3404.0	-2882.0
KPNA1	-4424.0	-4690.0
KPNB1	-3905.0	-5224.0
NDC1	-274.0	-4427.0
NUP107	389.0	2346.0
NUP133	-3872.0	2337.0
NUP153	-4958.0	2844.0
NUP155	-4984.0	-4426.0
NUP160	-5275.0	2064.0
NUP188	-4815.5	4873.5
NUP205	-4111.0	-3973.0
NUP210	-5538.0	-4937.0
NUP214	-2799.0	2906.0
NUP35	136.0	-4440.0
NUP43	-4918.0	526.0
NUP54	-1730.0	16.0
NUP85	-4237.0	-987.0
NUP88	215.0	1566.0
NUP93	-314.0	2592.0
RAE1	-4574.0	-3358.0
SEC13	2708.0	3637.0
TPR	-4118.0	-1199.0

---

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

metric	value
setSize	11
pMANOVA	0.0263
p.adjustMANOVA	0.13
s.dist	0.469
s.rna	-0.467
s.meth	0.0474
p.rna	0.00739
p.meth	0.786

Top 20 genes

Gene	rna	meth
SYMPK	-3268	3361
CPSF4	-4511	2241
CSTF2T	-1708	3804
CLP1	-1160	3345
CSTF2	-1473	635

Click HERE to show all gene set members

All member genes

	rna	meth
CLP1	-1160	3345
CPSF2	-2402	-297
CPSF4	-4511	2241
CSTF2	-1473	635
CSTF2T	-1708	3804
CSTF3	-1079	-4783
FIP1L1	-1975	-4470
NCBP1	-4694	-544
PCF11	-5280	-331
SYMPK	-3268	3361
WDR33	-5251	-733

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	29
pMANOVA	9.24e-05
p.adjustMANOVA	0.00285
s.dist	0.464
s.rna	0.449
s.meth	0.119
p.rna	2.9e-05
p.meth	0.267

Top 20 genes

Gene	rna	meth
RPL11	4947	4590
RPL5	4018	4289
RPS6	3227	5175
RPL14	3462	4737
FAU	2589	3679
RPS26	2095	1982
RPL7	2654	904
RPL8	1104	2033
RPL22L1	514	1840
RPS24	524	854
RPL22	3173	79

Click HERE to show all gene set members

All member genes

	rna	meth
FAU	2589	3679
PSTK	2523	-2451
RPL10	4285	-603
RPL11	4947	4590
RPL14	3462	4737
RPL15	-1395	3435
RPL22	3173	79
RPL22L1	514	1840
RPL23A	-1535	-4465
RPL26	3817	-3274
RPL28	4231	-19
RPL3	4185	-622
RPL31	4356	-3320
RPL34	3150	-981
RPL37	3516	-1820
RPL3L	-5817	1945
RPL5	4018	4289
RPL7	2654	904
RPL8	1104	2033
RPS14	3259	-156
RPS19	1113	-2067
RPS24	524	854
RPS26	2095	1982
RPS27	-178	4461
RPS6	3227	5175
RPS9	4095	-3291
SECISBP2	-3113	-3155
SEPHS2	3087	-1696
SEPSECS	-147	5101

---

---

Transcriptional regulation by small RNAs

Transcriptional regulation by small RNAs

metric	value
setSize	29
pMANOVA	0.000103
p.adjustMANOVA	0.00311
s.dist	0.461
s.rna	-0.454
s.meth	-0.0781
p.rna	2.31e-05
p.meth	0.467

Top 20 genes

Gene	rna	meth
NUP210	-5538	-4937
POLR2A	-5023	-5380
NUP155	-4984	-4426
NUP205	-4111	-3973
RAE1	-4574	-3358
AAAS	-3404	-2882
H2AFX	-2224	-4282
AGO1	-3291	-2265
POLR2B	-3789	-1748
TPR	-4118	-1199
NUP85	-4237	-987
NDC1	-274	-4427

Click HERE to show all gene set members

All member genes

	rna	meth
AAAS	-3404.0	-2882.0
AGO1	-3291.0	-2265.0
AGO2	-5587.0	542.0
H2AFX	-2224.0	-4282.0
IPO8	-5177.0	4556.0
NDC1	-274.0	-4427.0
NUP107	389.0	2346.0
NUP133	-3872.0	2337.0
NUP153	-4958.0	2844.0
NUP155	-4984.0	-4426.0
NUP160	-5275.0	2064.0
NUP188	-4815.5	4873.5
NUP205	-4111.0	-3973.0
NUP210	-5538.0	-4937.0
NUP214	-2799.0	2906.0
NUP35	136.0	-4440.0
NUP43	-4918.0	526.0
NUP54	-1730.0	16.0
NUP85	-4237.0	-987.0
NUP88	215.0	1566.0
NUP93	-314.0	2592.0
POLR2A	-5023.0	-5380.0
POLR2B	-3789.0	-1748.0
POLR2C	-3436.0	342.0
POLR2E	1685.0	-3734.0
RAE1	-4574.0	-3358.0
RAN	-1106.0	3003.0
SEC13	2708.0	3637.0
TPR	-4118.0	-1199.0

---

---

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

metric	value
setSize	13
pMANOVA	0.0172
p.adjustMANOVA	0.104
s.dist	0.46
s.rna	-0.225
s.meth	-0.401
p.rna	0.16
p.meth	0.0124

Top 20 genes

Gene	rna	meth
GATAD2A	-3864	-4706
MTA2	-5528	-2712
CHD4	-2527	-5119
H2AFX	-2224	-4282
HDAC2	-1180	-4049
CHD3	-4252	-1087
MBD3	-218	-763

Click HERE to show all gene set members

All member genes

	rna	meth
CHD3	-4252	-1087
CHD4	-2527	-5119
EHMT2	1811	894
ERCC6	-5458	2140
GATAD2A	-3864	-4706
H2AFX	-2224	-4282
HDAC2	-1180	-4049
MBD3	-218	-763
MTA1	1052	-2098
MTA2	-5528	-2712
MTA3	-521	1838
RBBP7	1196	-3811
TTF1	20	-5285

---

---

Viral Messenger RNA Synthesis

Viral Messenger RNA Synthesis

metric	value
setSize	25
pMANOVA	0.000415
p.adjustMANOVA	0.00833
s.dist	0.458
s.rna	-0.437
s.meth	-0.139
p.rna	0.000159
p.meth	0.231

Top 20 genes

Gene	rna	meth
NUP210	-5538	-4937
POLR2A	-5023	-5380
NUP155	-4984	-4426
NUP205	-4111	-3973
GTF2F1	-3364	-4749
RAE1	-4574	-3358
AAAS	-3404	-2882
POLR2B	-3789	-1748
TPR	-4118	-1199
NUP85	-4237	-987
NDC1	-274	-4427

Click HERE to show all gene set members

All member genes

	rna	meth
AAAS	-3404.0	-2882.0
GTF2F1	-3364.0	-4749.0
NDC1	-274.0	-4427.0
NUP107	389.0	2346.0
NUP133	-3872.0	2337.0
NUP153	-4958.0	2844.0
NUP155	-4984.0	-4426.0
NUP160	-5275.0	2064.0
NUP188	-4815.5	4873.5
NUP205	-4111.0	-3973.0
NUP210	-5538.0	-4937.0
NUP214	-2799.0	2906.0
NUP35	136.0	-4440.0
NUP43	-4918.0	526.0
NUP54	-1730.0	16.0
NUP85	-4237.0	-987.0
NUP88	215.0	1566.0
NUP93	-314.0	2592.0
POLR2A	-5023.0	-5380.0
POLR2B	-3789.0	-1748.0
POLR2C	-3436.0	342.0
POLR2E	1685.0	-3734.0
RAE1	-4574.0	-3358.0
SEC13	2708.0	3637.0
TPR	-4118.0	-1199.0

---

---

Interferon alpha/beta signaling

Interferon alpha/beta signaling

metric	value
setSize	37
pMANOVA	9.9e-06
p.adjustMANOVA	0.000509
s.dist	0.457
s.rna	0.453
s.meth	0.0591
p.rna	1.85e-06
p.meth	0.534

Top 20 genes

Gene	rna	meth
BST2	4831	4800
IFITM1	4979	4446
IFITM2	4979	4446
IFITM3	4979	4446
IRF7	4944	4259
IFNAR1	3453	4760
IFNAR2	3167	4919
SOCS3	3427	4458
PTPN1	4114	3669
EGR1	1816	4650
SAMHD1	4485	1851
STAT1	4872	1657
TYK2	1555	3375

Click HERE to show all gene set members

All member genes

	rna	meth
ADAR	2561.0	-3893.0
BST2	4831.0	4800.0
EGR1	1816.0	4650.0
IFI27	-4862.0	-201.0
IFIT2	2504.0	-1534.0
IFITM1	4979.0	4446.0
IFITM2	4979.0	4446.0
IFITM3	4979.0	4446.0
IFNAR1	3453.0	4760.0
IFNAR2	3167.0	4919.0
IRF1	3212.0	-2676.0
IRF3	-1108.0	-824.0
IRF4	-2952.0	-2042.0
IRF5	-1863.0	-4976.0
IRF6	-4946.0	-3214.0
IRF7	4944.0	4259.0
IRF8	4287.0	-2797.0
IRF9	4102.0	-1956.0
ISG20	-2479.0	-847.0
JAK1	-1732.0	-2624.0
MX1	4959.0	-434.0
OAS1	4988.0	-3635.0
OAS2	4962.0	-404.0
OAS3	-880.0	-876.0
OASL	2964.0	-2516.0
PSMB8	4263.0	-4966.0
PTPN1	4114.0	3669.0
PTPN11	-1608.0	671.0
PTPN6	-1241.0	-2911.0
RNASEL	-367.0	3513.0
RSAD2	-964.0	856.0
SAMHD1	4485.0	1851.0
SOCS3	3427.0	4458.0
STAT1	4872.0	1657.0
TYK2	1555.0	3375.0
USP18	4314.5	-2599.5
XAF1	4798.0	-1016.0

---

---

Biosynthesis of specialized proresolving mediators (SPMs)

Biosynthesis of specialized proresolving mediators (SPMs)

metric	value
setSize	11
pMANOVA	0.035
p.adjustMANOVA	0.156
s.dist	0.45
s.rna	0.444
s.meth	-0.0723
p.rna	0.0108
p.meth	0.678

Top 20 genes

Gene	rna	meth
LTA4H	3342	-3523
GSTM4	1155	-5219
ALOX5	2239	-2570
PTGR1	2962	-1042

Click HERE to show all gene set members

All member genes

	rna	meth
ALOX12	1219	2298
ALOX15	4937	4553
ALOX5	2239	-2570
ALOX5AP	4936	1997
CYP2D6	-1151	1416
CYP2E1	-2345	-4912
GPX4	-559	692
GSTM4	1155	-5219
HPGD	4934	1383
LTA4H	3342	-3523
PTGR1	2962	-1042

---

---

Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere

metric	value
setSize	16
pMANOVA	0.00835
p.adjustMANOVA	0.0632
s.dist	0.45
s.rna	-0.246
s.meth	-0.376
p.rna	0.0881
p.meth	0.00916

Top 20 genes

Gene	rna	meth
CENPT	-4516	-4435
RSF1	-5408	-3459
CENPI	-3248	-5103
H2AFX	-2224	-4282
CENPQ	-1724	-5402
CENPA	-4165	-2031
SMARCA5	-1539	-5243
MIS18BP1	-1768	-2387
CENPH	-3657	-1062
CENPN	-1703	-2060

Click HERE to show all gene set members

All member genes

	rna	meth
CENPA	-4165	-2031
CENPC	249	-3715
CENPH	-3657	-1062
CENPI	-3248	-5103
CENPM	2045	-4014
CENPN	-1703	-2060
CENPO	-2058	4641
CENPQ	-1724	-5402
CENPT	-4516	-4435
H2AFX	-2224	-4282
HJURP	-302	4532
MIS18BP1	-1768	-2387
RBBP7	1196	-3811
RSF1	-5408	-3459
RUVBL1	275	4214
SMARCA5	-1539	-5243

---

---

Nucleosome assembly

Nucleosome assembly

metric	value
setSize	16
pMANOVA	0.00835
p.adjustMANOVA	0.0632
s.dist	0.45
s.rna	-0.246
s.meth	-0.376
p.rna	0.0881
p.meth	0.00916

Top 20 genes

Gene	rna	meth
CENPT	-4516	-4435
RSF1	-5408	-3459
CENPI	-3248	-5103
H2AFX	-2224	-4282
CENPQ	-1724	-5402
CENPA	-4165	-2031
SMARCA5	-1539	-5243
MIS18BP1	-1768	-2387
CENPH	-3657	-1062
CENPN	-1703	-2060

Click HERE to show all gene set members

All member genes

	rna	meth
CENPA	-4165	-2031
CENPC	249	-3715
CENPH	-3657	-1062
CENPI	-3248	-5103
CENPM	2045	-4014
CENPN	-1703	-2060
CENPO	-2058	4641
CENPQ	-1724	-5402
CENPT	-4516	-4435
H2AFX	-2224	-4282
HJURP	-302	4532
MIS18BP1	-1768	-2387
RBBP7	1196	-3811
RSF1	-5408	-3459
RUVBL1	275	4214
SMARCA5	-1539	-5243

---

---

TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling

metric	value
setSize	12
pMANOVA	0.0264
p.adjustMANOVA	0.13
s.dist	0.45
s.rna	0.00414
s.meth	-0.45
p.rna	0.98
p.meth	0.00702

Top 20 genes

Gene	rna	meth
TNF	3276	-4590
USP21	2426	-3441
TNFRSF1A	3748	-1779
FADD	4860	-1188
TRADD	1578	-524

Click HERE to show all gene set members

All member genes

	rna	meth
CASP8	-25	-4244
CYLD	-1882	-1395
FADD	4860	-1188
OTUD7B	-4468	-3253
RIPK1	-2193	-4700
TNF	3276	-4590
TNFAIP3	-5179	3520
TNFRSF1A	3748	-1779
TRADD	1578	-524
TRAF2	-2115	-5410
USP2	-5096	-2986
USP21	2426	-3441

---

---

Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of Mature mRNAs Derived from Intronless Transcripts

metric	value
setSize	29
pMANOVA	0.000164
p.adjustMANOVA	0.00451
s.dist	0.449
s.rna	-0.439
s.meth	-0.0982
p.rna	4.38e-05
p.meth	0.36

Top 20 genes

Gene	rna	meth
NUP210	-5538	-4937
NUP155	-4984	-4426
NUP205	-4111	-3973
SLBP	-4129	-3873
RAE1	-4574	-3358
AAAS	-3404	-2882
FIP1L1	-1975	-4470
NXF1	-3226	-2342
TPR	-4118	-1199
NUP85	-4237	-987
WDR33	-5251	-733
NCBP1	-4694	-544
NDC1	-274	-4427
CPSF2	-2402	-297

Click HERE to show all gene set members

All member genes

	rna	meth
AAAS	-3404.0	-2882.0
ALYREF	3977.0	-5481.0
CPSF2	-2402.0	-297.0
CPSF4	-4511.0	2241.0
FIP1L1	-1975.0	-4470.0
NCBP1	-4694.0	-544.0
NDC1	-274.0	-4427.0
NUP107	389.0	2346.0
NUP133	-3872.0	2337.0
NUP153	-4958.0	2844.0
NUP155	-4984.0	-4426.0
NUP160	-5275.0	2064.0
NUP188	-4815.5	4873.5
NUP205	-4111.0	-3973.0
NUP210	-5538.0	-4937.0
NUP214	-2799.0	2906.0
NUP35	136.0	-4440.0
NUP43	-4918.0	526.0
NUP54	-1730.0	16.0
NUP85	-4237.0	-987.0
NUP88	215.0	1566.0
NUP93	-314.0	2592.0
NXF1	-3226.0	-2342.0
RAE1	-4574.0	-3358.0
SEC13	2708.0	3637.0
SLBP	-4129.0	-3873.0
SYMPK	-3268.0	3361.0
TPR	-4118.0	-1199.0
WDR33	-5251.0	-733.0

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	29
pMANOVA	0.000174
p.adjustMANOVA	0.00466
s.dist	0.448
s.rna	0.442
s.meth	0.0681
p.rna	3.76e-05
p.meth	0.526

Top 20 genes

Gene	rna	meth
RPL11	4947	4590
RPL5	4018	4289
RPS6	3227	5175
RPL14	3462	4737
FAU	2589	3679
RPS26	2095	1982
RPL7	2654	904
RPL8	1104	2033
RPL22L1	514	1840
RPS24	524	854
RPL22	3173	79

Click HERE to show all gene set members

All member genes

	rna	meth
APEH	-3930	-3998
FAU	2589	3679
GSPT1	-551	553
GSPT2	1207	-1362
N6AMT1	4626	-5456
RPL10	4285	-603
RPL11	4947	4590
RPL14	3462	4737
RPL15	-1395	3435
RPL22	3173	79
RPL22L1	514	1840
RPL23A	-1535	-4465
RPL26	3817	-3274
RPL28	4231	-19
RPL3	4185	-622
RPL31	4356	-3320
RPL34	3150	-981
RPL37	3516	-1820
RPL3L	-5817	1945
RPL5	4018	4289
RPL7	2654	904
RPL8	1104	2033
RPS14	3259	-156
RPS19	1113	-2067
RPS24	524	854
RPS26	2095	1982
RPS27	-178	4461
RPS6	3227	5175
RPS9	4095	-3291

---

---

Export of Viral Ribonucleoproteins from Nucleus

Export of Viral Ribonucleoproteins from Nucleus

metric	value
setSize	23
pMANOVA	0.00115
p.adjustMANOVA	0.0175
s.dist	0.444
s.rna	-0.442
s.meth	-0.0462
p.rna	0.000247
p.meth	0.701

Top 20 genes

Gene	rna	meth
HSPA1A	-5820.5	-5011.5
NUP210	-5538.0	-4937.0
NUP155	-4984.0	-4426.0
NUP205	-4111.0	-3973.0
RAE1	-4574.0	-3358.0
AAAS	-3404.0	-2882.0
TPR	-4118.0	-1199.0
NUP85	-4237.0	-987.0
NDC1	-274.0	-4427.0
XPO1	-2004.0	-109.0

Click HERE to show all gene set members

All member genes

	rna	meth
AAAS	-3404.0	-2882.0
HSPA1A	-5820.5	-5011.5
NDC1	-274.0	-4427.0
NUP107	389.0	2346.0
NUP133	-3872.0	2337.0
NUP153	-4958.0	2844.0
NUP155	-4984.0	-4426.0
NUP160	-5275.0	2064.0
NUP188	-4815.5	4873.5
NUP205	-4111.0	-3973.0
NUP210	-5538.0	-4937.0
NUP214	-2799.0	2906.0
NUP35	136.0	-4440.0
NUP43	-4918.0	526.0
NUP54	-1730.0	16.0
NUP85	-4237.0	-987.0
NUP88	215.0	1566.0
NUP93	-314.0	2592.0
RAE1	-4574.0	-3358.0
RAN	-1106.0	3003.0
SEC13	2708.0	3637.0
TPR	-4118.0	-1199.0
XPO1	-2004.0	-109.0

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0   GGally_2.0.0    ggplot2_3.3.2   reshape2_1.4.4 
##  [5] beeswarm_0.2.3  gplots_3.0.3    gtools_3.8.2    tibble_3.0.1   
##  [9] dplyr_1.0.0     echarts4r_0.3.2 mitch_1.0.6    
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.4.6       assertthat_0.2.1   rprojroot_1.3-2    digest_0.6.25     
##  [5] mime_0.9           R6_2.4.1           plyr_1.8.6         backports_1.1.8   
##  [9] evaluate_0.14      highr_0.8          pillar_1.4.4       rlang_0.4.6       
## [13] gdata_2.18.0       rmarkdown_2.3      desc_1.2.0         labeling_0.3      
## [17] stringr_1.4.0      htmlwidgets_1.5.1  munsell_0.5.0      shiny_1.5.0       
## [21] compiler_4.0.2     httpuv_1.5.4       xfun_0.15          pkgconfig_2.0.3   
## [25] htmltools_0.5.0    tidyselect_1.1.0   gridExtra_2.3      reshape_0.8.8     
## [29] crayon_1.3.4       withr_2.2.0        later_1.1.0.1      MASS_7.3-51.6     
## [33] bitops_1.0-6       grid_4.0.2         jsonlite_1.7.0     xtable_1.8-4      
## [37] gtable_0.3.0       lifecycle_0.2.0    magrittr_1.5       scales_1.1.1      
## [41] KernSmooth_2.23-17 stringi_1.4.6      farver_2.0.3       promises_1.1.1    
## [45] testthat_2.3.2     ellipsis_0.3.1     generics_0.0.2     vctrs_0.3.1       
## [49] pbmcapply_1.5.0    RColorBrewer_1.1-2 tools_4.0.2        glue_1.4.1        
## [53] purrr_0.3.4        parallel_4.0.2     fastmap_1.0.1      yaml_2.2.1        
## [57] colorspace_1.4-1   caTools_1.18.0     knitr_1.29

END of report