date generated: 2020-07-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## 5S_rRNA  3.1729765
## 7SK      4.1979466
## A1BG     0.4203060
## A1CF    -0.7100788
## A2M      0.7954409
## A3GALT2 -1.2495566

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 16348
duplicated_genes_present 0
num_profile_genes_in_sets 8696
num_profile_genes_not_in_sets 7652

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1009
num_genesets_included 1391

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set setSize pANOVA s.dist p.adjustANOVA
Olfactory Signaling Pathway 279 4.49e-71 0.619 6.25e-68
Glucuronidation 17 1.53e-04 0.530 2.33e-02
Passive transport by Aquaporins 12 4.60e-03 -0.472 2.97e-01
TRAF6 mediated IRF7 activation 28 2.21e-05 0.463 3.85e-03
G alpha (s) signalling events 408 4.62e-50 0.429 3.21e-47
Class C/3 (Metabotropic glutamate/pheromone receptors) 34 1.62e-05 0.427 3.21e-03
PI3K events in ERBB4 signaling 10 2.04e-02 0.423 4.21e-01
Removal of the Flap Intermediate 11 1.60e-02 -0.419 4.21e-01
SHC1 events in ERBB4 signaling 14 7.62e-03 0.412 3.74e-01
Regulation of IFNA signaling 25 4.86e-04 0.403 5.20e-02
Diseases associated with glycosylation precursor biosynthesis 16 5.47e-03 -0.401 3.31e-01
ATF6 (ATF6-alpha) activates chaperones 10 2.94e-02 0.398 4.39e-01
Glutathione synthesis and recycling 12 1.80e-02 -0.394 4.21e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 12 1.95e-02 0.390 4.21e-01
GRB2 events in ERBB2 signaling 16 7.19e-03 0.388 3.74e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 2.69e-02 0.385 4.21e-01
Synthesis of PA 30 2.68e-04 -0.384 3.39e-02
Mitotic Telophase/Cytokinesis 10 3.58e-02 0.383 4.69e-01
Adherens junctions interactions 24 1.20e-03 0.382 1.11e-01
GRB2 events in EGFR signaling 13 1.72e-02 0.382 4.21e-01
MET activates RAP1 and RAC1 11 3.07e-02 0.376 4.50e-01
Metabolism of folate and pterines 14 1.54e-02 -0.374 4.21e-01
Dermatan sulfate biosynthesis 11 3.19e-02 0.374 4.51e-01
Glutamate and glutamine metabolism 13 2.16e-02 -0.368 4.21e-01
Acyl chain remodelling of PS 18 8.55e-03 -0.358 3.74e-01
Pre-NOTCH Processing in Golgi 14 2.08e-02 -0.357 4.21e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 14 2.18e-02 -0.354 4.21e-01
Aflatoxin activation and detoxification 16 1.44e-02 -0.353 4.21e-01
SHC1 events in EGFR signaling 14 2.31e-02 0.351 4.21e-01
Termination of O-glycan biosynthesis 19 9.85e-03 -0.342 4.15e-01
PI3K events in ERBB2 signaling 16 1.99e-02 0.336 4.21e-01
Activation of RAC1 12 4.43e-02 0.335 5.01e-01
Removal of the Flap Intermediate from the C-strand 12 4.48e-02 -0.335 5.01e-01
Gluconeogenesis 29 1.87e-03 -0.334 1.63e-01
Processive synthesis on the lagging strand 12 4.69e-02 -0.331 5.01e-01
XBP1(S) activates chaperone genes 42 3.05e-04 -0.322 3.54e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 16 2.64e-02 0.321 4.21e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 16 2.69e-02 0.319 4.21e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 16 2.69e-02 0.319 4.21e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 13 4.67e-02 0.319 5.01e-01
Receptor-type tyrosine-protein phosphatases 19 1.62e-02 0.319 4.21e-01
Polymerase switching on the C-strand of the telomere 21 1.17e-02 -0.318 4.21e-01
Constitutive Signaling by EGFRvIII 15 3.36e-02 0.317 4.63e-01
Signaling by EGFRvIII in Cancer 15 3.36e-02 0.317 4.63e-01
Signaling by EGFR in Cancer 22 1.08e-02 0.314 4.21e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 2.53e-02 -0.313 4.21e-01
CD209 (DC-SIGN) signaling 19 1.84e-02 0.312 4.21e-01
Acyl chain remodelling of PI 14 4.33e-02 -0.312 5.01e-01
Signaling by Leptin 10 8.82e-02 -0.311 6.23e-01
Activated NTRK2 signals through FRS2 and FRS3 10 8.91e-02 0.310 6.23e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Olfactory Signaling Pathway 279 4.49e-71 0.619000 6.25e-68
Glucuronidation 17 1.53e-04 0.530000 2.33e-02
Passive transport by Aquaporins 12 4.60e-03 -0.472000 2.97e-01
TRAF6 mediated IRF7 activation 28 2.21e-05 0.463000 3.85e-03
G alpha (s) signalling events 408 4.62e-50 0.429000 3.21e-47
Class C/3 (Metabotropic glutamate/pheromone receptors) 34 1.62e-05 0.427000 3.21e-03
PI3K events in ERBB4 signaling 10 2.04e-02 0.423000 4.21e-01
Removal of the Flap Intermediate 11 1.60e-02 -0.419000 4.21e-01
SHC1 events in ERBB4 signaling 14 7.62e-03 0.412000 3.74e-01
Regulation of IFNA signaling 25 4.86e-04 0.403000 5.20e-02
Diseases associated with glycosylation precursor biosynthesis 16 5.47e-03 -0.401000 3.31e-01
ATF6 (ATF6-alpha) activates chaperones 10 2.94e-02 0.398000 4.39e-01
Glutathione synthesis and recycling 12 1.80e-02 -0.394000 4.21e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 12 1.95e-02 0.390000 4.21e-01
GRB2 events in ERBB2 signaling 16 7.19e-03 0.388000 3.74e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 2.69e-02 0.385000 4.21e-01
Synthesis of PA 30 2.68e-04 -0.384000 3.39e-02
Mitotic Telophase/Cytokinesis 10 3.58e-02 0.383000 4.69e-01
Adherens junctions interactions 24 1.20e-03 0.382000 1.11e-01
GRB2 events in EGFR signaling 13 1.72e-02 0.382000 4.21e-01
MET activates RAP1 and RAC1 11 3.07e-02 0.376000 4.50e-01
Metabolism of folate and pterines 14 1.54e-02 -0.374000 4.21e-01
Dermatan sulfate biosynthesis 11 3.19e-02 0.374000 4.51e-01
Glutamate and glutamine metabolism 13 2.16e-02 -0.368000 4.21e-01
Acyl chain remodelling of PS 18 8.55e-03 -0.358000 3.74e-01
Pre-NOTCH Processing in Golgi 14 2.08e-02 -0.357000 4.21e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 14 2.18e-02 -0.354000 4.21e-01
Aflatoxin activation and detoxification 16 1.44e-02 -0.353000 4.21e-01
SHC1 events in EGFR signaling 14 2.31e-02 0.351000 4.21e-01
Termination of O-glycan biosynthesis 19 9.85e-03 -0.342000 4.15e-01
PI3K events in ERBB2 signaling 16 1.99e-02 0.336000 4.21e-01
Activation of RAC1 12 4.43e-02 0.335000 5.01e-01
Removal of the Flap Intermediate from the C-strand 12 4.48e-02 -0.335000 5.01e-01
Gluconeogenesis 29 1.87e-03 -0.334000 1.63e-01
Processive synthesis on the lagging strand 12 4.69e-02 -0.331000 5.01e-01
XBP1(S) activates chaperone genes 42 3.05e-04 -0.322000 3.54e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 16 2.64e-02 0.321000 4.21e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 16 2.69e-02 0.319000 4.21e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 16 2.69e-02 0.319000 4.21e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 13 4.67e-02 0.319000 5.01e-01
Receptor-type tyrosine-protein phosphatases 19 1.62e-02 0.319000 4.21e-01
Polymerase switching on the C-strand of the telomere 21 1.17e-02 -0.318000 4.21e-01
Constitutive Signaling by EGFRvIII 15 3.36e-02 0.317000 4.63e-01
Signaling by EGFRvIII in Cancer 15 3.36e-02 0.317000 4.63e-01
Signaling by EGFR in Cancer 22 1.08e-02 0.314000 4.21e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 2.53e-02 -0.313000 4.21e-01
CD209 (DC-SIGN) signaling 19 1.84e-02 0.312000 4.21e-01
Acyl chain remodelling of PI 14 4.33e-02 -0.312000 5.01e-01
Signaling by Leptin 10 8.82e-02 -0.311000 6.23e-01
Activated NTRK2 signals through FRS2 and FRS3 10 8.91e-02 0.310000 6.23e-01
MET activates RAS signaling 11 7.63e-02 0.309000 5.99e-01
Apoptotic cleavage of cell adhesion proteins 10 9.14e-02 0.308000 6.29e-01
Nucleobase biosynthesis 13 5.57e-02 -0.306000 5.31e-01
Regulation of TLR by endogenous ligand 15 4.26e-02 0.302000 5.01e-01
Degradation of cysteine and homocysteine 11 8.49e-02 -0.300000 6.23e-01
IRE1alpha activates chaperones 44 6.20e-04 -0.298000 6.16e-02
ERBB2 Regulates Cell Motility 14 5.63e-02 0.295000 5.32e-01
Lagging Strand Synthesis 17 3.58e-02 -0.294000 4.69e-01
Signaling by ERBB2 KD Mutants 24 1.33e-02 0.292000 4.21e-01
Interleukin-20 family signaling 24 1.39e-02 -0.290000 4.21e-01
Signaling by ERBB2 in Cancer 25 1.22e-02 0.290000 4.21e-01
Fertilization 22 1.91e-02 -0.289000 4.21e-01
Activation of AMPK downstream of NMDARs 10 1.17e-01 -0.286000 6.34e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 15 5.57e-02 -0.285000 5.31e-01
Diseases of hemostasis 15 5.57e-02 -0.285000 5.31e-01
Metabolism of amine-derived hormones 16 4.85e-02 -0.285000 5.07e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.20e-01 -0.284000 6.34e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.20e-01 0.284000 6.34e-01
Caspase activation via Death Receptors in the presence of ligand 16 4.96e-02 0.284000 5.07e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 24 1.64e-02 0.283000 4.21e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 11 1.04e-01 -0.283000 6.34e-01
Carboxyterminal post-translational modifications of tubulin 35 3.89e-03 -0.282000 2.80e-01
Leading Strand Synthesis 13 7.85e-02 -0.282000 6.07e-01
Polymerase switching 13 7.85e-02 -0.282000 6.07e-01
Signaling by ERBB2 TMD/JMD mutants 21 2.54e-02 0.282000 4.21e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.06e-01 -0.281000 6.34e-01
Acyl chain remodelling of PG 15 6.04e-02 -0.280000 5.60e-01
PINK1-PRKN Mediated Mitophagy 14 7.01e-02 -0.280000 5.84e-01
Synthesis of PE 10 1.26e-01 -0.279000 6.42e-01
ERBB2 Activates PTK6 Signaling 13 8.33e-02 0.277000 6.20e-01
Citric acid cycle (TCA cycle) 18 4.20e-02 0.277000 5.01e-01
Deadenylation of mRNA 20 3.21e-02 0.277000 4.51e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 11 1.15e-01 -0.275000 6.34e-01
Prolonged ERK activation events 14 7.63e-02 0.274000 5.99e-01
Frs2-mediated activation 12 1.08e-01 0.268000 6.34e-01
Fanconi Anemia Pathway 24 2.33e-02 -0.268000 4.21e-01
IL-6-type cytokine receptor ligand interactions 16 6.44e-02 -0.267000 5.62e-01
Signaling by FGFR4 in disease 11 1.28e-01 0.265000 6.43e-01
Xenobiotics 23 2.86e-02 0.264000 4.33e-01
EGFR downregulation 28 1.58e-02 0.264000 4.21e-01
Termination of translesion DNA synthesis 24 2.60e-02 -0.263000 4.21e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 1.15e-01 -0.263000 6.34e-01
Signaling by NODAL 18 5.45e-02 -0.262000 5.31e-01
Cellular hexose transport 20 4.35e-02 -0.261000 5.01e-01
Regulation of PTEN mRNA translation 14 9.39e-02 0.259000 6.34e-01
Cleavage of the damaged pyrimidine 13 1.08e-01 -0.258000 6.34e-01
Depyrimidination 13 1.08e-01 -0.258000 6.34e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 13 1.08e-01 -0.258000 6.34e-01
Glyoxylate metabolism and glycine degradation 28 1.90e-02 -0.256000 4.21e-01
Base-Excision Repair, AP Site Formation 15 8.71e-02 -0.255000 6.23e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 20 4.89e-02 0.254000 5.07e-01
PIWI-interacting RNA (piRNA) biogenesis 20 4.92e-02 -0.254000 5.07e-01
Telomere C-strand (Lagging Strand) Synthesis 27 2.27e-02 -0.253000 4.21e-01
STING mediated induction of host immune responses 12 1.29e-01 -0.253000 6.44e-01
Telomere C-strand synthesis initiation 10 1.72e-01 -0.250000 6.82e-01
Negative regulation of MET activity 18 6.77e-02 0.249000 5.71e-01
Defective GALNT12 causes colorectal cancer 1 (CRCS1) 13 1.25e-01 -0.246000 6.42e-01
Sulfur amino acid metabolism 22 4.62e-02 -0.246000 5.01e-01
SUMOylation of DNA methylation proteins 15 1.01e-01 -0.244000 6.34e-01
Synthesis of substrates in N-glycan biosythesis 53 2.20e-03 -0.243000 1.70e-01
Sema4D induced cell migration and growth-cone collapse 19 6.72e-02 -0.243000 5.70e-01
Regulation of necroptotic cell death 13 1.30e-01 0.243000 6.44e-01
Sialic acid metabolism 28 2.68e-02 -0.242000 4.21e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 27 2.98e-02 0.242000 4.42e-01
CLEC7A (Dectin-1) induces NFAT activation 10 1.87e-01 0.241000 6.82e-01
Cholesterol biosynthesis 20 6.35e-02 -0.240000 5.62e-01
Pausing and recovery of Tat-mediated HIV elongation 20 6.48e-02 -0.239000 5.62e-01
Tat-mediated HIV elongation arrest and recovery 20 6.48e-02 -0.239000 5.62e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.53e-01 0.238000 6.75e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 11 1.74e-01 -0.237000 6.82e-01
RMTs methylate histone arginines 30 2.57e-02 -0.235000 4.21e-01
Mismatch Repair 13 1.43e-01 -0.235000 6.70e-01
Signaling by FGFR3 fusions in cancer 10 1.99e-01 0.235000 6.82e-01
Signaling by ERBB2 ECD mutants 15 1.16e-01 0.234000 6.34e-01
LGI-ADAM interactions 13 1.44e-01 -0.234000 6.70e-01
Diseases of carbohydrate metabolism 27 3.59e-02 -0.233000 4.69e-01
Regulation of TP53 Activity through Acetylation 27 3.61e-02 -0.233000 4.69e-01
DSCAM interactions 11 1.82e-01 0.232000 6.82e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 1.63e-01 -0.232000 6.75e-01
Processing of SMDT1 11 1.83e-01 -0.232000 6.82e-01
The NLRP3 inflammasome 13 1.49e-01 -0.231000 6.74e-01
Interleukin-2 signaling 11 1.84e-01 -0.231000 6.82e-01
Amino acid transport across the plasma membrane 31 2.63e-02 -0.231000 4.21e-01
Signaling by FGFR3 in disease 22 6.30e-02 0.229000 5.62e-01
Signaling by FGFR3 point mutants in cancer 22 6.30e-02 0.229000 5.62e-01
Spry regulation of FGF signaling 13 1.57e-01 0.227000 6.75e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 11 1.94e-01 0.226000 6.82e-01
Apoptotic factor-mediated response 12 1.77e-01 -0.225000 6.82e-01
Creatine metabolism 10 2.18e-01 -0.225000 6.93e-01
Pyrimidine catabolism 11 1.97e-01 0.225000 6.82e-01
Protein ubiquitination 42 1.21e-02 0.224000 4.21e-01
Translocation of ZAP-70 to Immunological synapse 12 1.80e-01 -0.224000 6.82e-01
Signaling by FGFR3 36 2.07e-02 0.223000 4.21e-01
Establishment of Sister Chromatid Cohesion 10 2.25e-01 0.222000 6.94e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 65 2.03e-03 -0.221000 1.66e-01
Signaling by Activin 12 1.87e-01 0.220000 6.82e-01
Transport of organic anions 11 2.07e-01 0.220000 6.87e-01
Role of LAT2/NTAL/LAB on calcium mobilization 17 1.17e-01 0.220000 6.34e-01
Interleukin-6 family signaling 23 6.84e-02 -0.220000 5.73e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 11 2.09e-01 -0.219000 6.87e-01
Post-chaperonin tubulin folding pathway 22 8.00e-02 -0.216000 6.10e-01
MECP2 regulates neuronal receptors and channels 17 1.25e-01 0.215000 6.42e-01
Erythrocytes take up carbon dioxide and release oxygen 11 2.20e-01 0.214000 6.93e-01
O2/CO2 exchange in erythrocytes 11 2.20e-01 0.214000 6.93e-01
RHO GTPases Activate NADPH Oxidases 23 7.67e-02 -0.213000 5.99e-01
Signaling by FGFR2 61 4.02e-03 0.213000 2.80e-01
Synthesis of PIPs at the late endosome membrane 10 2.47e-01 0.212000 7.11e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 18 1.20e-01 0.212000 6.34e-01
Regulation of beta-cell development 36 2.85e-02 0.211000 4.33e-01
Mitophagy 20 1.03e-01 -0.211000 6.34e-01
PKA-mediated phosphorylation of CREB 19 1.12e-01 0.210000 6.34e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 10 2.49e-01 -0.210000 7.11e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 11 2.28e-01 0.210000 6.97e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.75e-01 0.209000 6.82e-01
WNT5A-dependent internalization of FZD4 14 1.77e-01 -0.208000 6.82e-01
PD-1 signaling 15 1.64e-01 -0.208000 6.75e-01
Regulation of TP53 Activity through Methylation 13 1.97e-01 -0.207000 6.82e-01
Sodium/Calcium exchangers 10 2.59e-01 0.206000 7.11e-01
Acyl chain remodelling of PC 23 8.73e-02 -0.206000 6.23e-01
Other interleukin signaling 20 1.12e-01 -0.205000 6.34e-01
Selective autophagy 50 1.22e-02 -0.205000 4.21e-01
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 13 2.01e-01 -0.205000 6.82e-01
Kinesins 39 2.73e-02 -0.204000 4.21e-01
E3 ubiquitin ligases ubiquitinate target proteins 26 7.25e-02 0.204000 5.97e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 11 2.44e-01 -0.203000 7.10e-01
Signal regulatory protein family interactions 13 2.06e-01 0.203000 6.87e-01
The canonical retinoid cycle in rods (twilight vision) 20 1.17e-01 -0.203000 6.34e-01
HDACs deacetylate histones 26 7.39e-02 -0.203000 5.99e-01
Gastrin-CREB signalling pathway via PKC and MAPK 18 1.37e-01 0.202000 6.63e-01
Regulation of pyruvate dehydrogenase (PDH) complex 13 2.07e-01 -0.202000 6.87e-01
VLDLR internalisation and degradation 12 2.28e-01 -0.201000 6.97e-01
Processive synthesis on the C-strand of the telomere 14 1.93e-01 -0.201000 6.82e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 13 2.10e-01 0.201000 6.87e-01
Signaling by FGFR1 45 1.99e-02 0.201000 4.21e-01
Downstream signaling of activated FGFR3 24 8.93e-02 0.200000 6.23e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 2.74e-01 0.200000 7.27e-01
Gap junction assembly 16 1.67e-01 -0.200000 6.77e-01
Striated Muscle Contraction 33 4.71e-02 -0.200000 5.01e-01
IRF3-mediated induction of type I IFN 10 2.75e-01 -0.199000 7.27e-01
Hyaluronan uptake and degradation 11 2.53e-01 -0.199000 7.11e-01
GPCR downstream signalling 920 3.51e-24 0.198000 1.63e-21
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 14 1.99e-01 -0.198000 6.82e-01
Dual Incision in GG-NER 34 4.58e-02 -0.198000 5.01e-01
Recycling of bile acids and salts 15 1.85e-01 0.198000 6.82e-01
CASP8 activity is inhibited 11 2.58e-01 0.197000 7.11e-01
Dimerization of procaspase-8 11 2.58e-01 0.197000 7.11e-01
Regulation by c-FLIP 11 2.58e-01 0.197000 7.11e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 2.03e-01 -0.196000 6.86e-01
Tight junction interactions 28 7.25e-02 -0.196000 5.97e-01
Acyl chain remodelling of PE 21 1.20e-01 -0.196000 6.34e-01
HIV elongation arrest and recovery 21 1.20e-01 -0.196000 6.34e-01
Pausing and recovery of HIV elongation 21 1.20e-01 -0.196000 6.34e-01
FCERI mediated MAPK activation 31 5.94e-02 0.196000 5.58e-01
Nephrin family interactions 21 1.22e-01 0.195000 6.39e-01
Signaling by EGFR 46 2.21e-02 0.195000 4.21e-01
FGFR2 alternative splicing 19 1.42e-01 0.195000 6.70e-01
Ketone body metabolism 10 2.87e-01 -0.194000 7.27e-01
Metalloprotease DUBs 17 1.70e-01 0.192000 6.82e-01
Sema4D in semaphorin signaling 22 1.19e-01 -0.192000 6.34e-01
Repression of WNT target genes 12 2.53e-01 -0.191000 7.11e-01
Processing of Capped Intronless Pre-mRNA 19 1.50e-01 0.191000 6.74e-01
Signaling by GPCR 976 2.34e-23 0.190000 8.13e-21
ROS and RNS production in phagocytes 33 6.17e-02 -0.188000 5.61e-01
Keratan sulfate degradation 10 3.05e-01 0.187000 7.39e-01
Listeria monocytogenes entry into host cells 17 1.82e-01 0.187000 6.82e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 11 2.83e-01 -0.187000 7.27e-01
Depolymerisation of the Nuclear Lamina 14 2.26e-01 -0.187000 6.97e-01
Transcriptional Regulation by MECP2 55 1.66e-02 0.187000 4.21e-01
Purine ribonucleoside monophosphate biosynthesis 11 2.83e-01 -0.187000 7.27e-01
Regulation of innate immune responses to cytosolic DNA 11 2.84e-01 -0.186000 7.27e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 2.86e-01 -0.186000 7.27e-01
alpha-linolenic acid (ALA) metabolism 11 2.86e-01 -0.186000 7.27e-01
Incretin synthesis, secretion, and inactivation 21 1.41e-01 0.185000 6.70e-01
Regulation of signaling by NODAL 10 3.10e-01 -0.185000 7.39e-01
Downstream signaling of activated FGFR2 29 8.46e-02 0.185000 6.23e-01
Activation of the phototransduction cascade 11 2.88e-01 -0.185000 7.27e-01
tRNA modification in the nucleus and cytosol 31 7.50e-02 -0.185000 5.99e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 19 1.64e-01 -0.184000 6.75e-01
Neurodegenerative Diseases 19 1.64e-01 -0.184000 6.75e-01
Cell recruitment (pro-inflammatory response) 21 1.44e-01 -0.184000 6.70e-01
Purinergic signaling in leishmaniasis infection 21 1.44e-01 -0.184000 6.70e-01
Peroxisomal lipid metabolism 26 1.04e-01 -0.184000 6.34e-01
MicroRNA (miRNA) biogenesis 15 2.17e-01 -0.184000 6.93e-01
Diseases of programmed cell death 20 1.55e-01 -0.184000 6.75e-01
Neurotoxicity of clostridium toxins 10 3.15e-01 -0.183000 7.39e-01
Dopamine Neurotransmitter Release Cycle 19 1.66e-01 0.183000 6.77e-01
FGFRL1 modulation of FGFR1 signaling 13 2.54e-01 0.183000 7.11e-01
IKK complex recruitment mediated by RIP1 17 1.93e-01 0.183000 6.82e-01
Uptake and actions of bacterial toxins 29 8.90e-02 -0.182000 6.23e-01
RIPK1-mediated regulated necrosis 15 2.22e-01 0.182000 6.94e-01
Regulated Necrosis 15 2.22e-01 0.182000 6.94e-01
Zinc transporters 14 2.39e-01 -0.182000 7.09e-01
Pyruvate metabolism 25 1.19e-01 -0.180000 6.34e-01
Reproduction 74 7.67e-03 -0.179000 3.74e-01
Lysosome Vesicle Biogenesis 30 8.98e-02 -0.179000 6.23e-01
SHC-mediated cascade:FGFR3 18 1.90e-01 0.178000 6.82e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 16 2.18e-01 -0.178000 6.93e-01
Netrin-1 signaling 49 3.18e-02 0.177000 4.51e-01
Syndecan interactions 17 2.06e-01 -0.177000 6.87e-01
Other semaphorin interactions 18 1.96e-01 0.176000 6.82e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 1.84e-01 0.176000 6.82e-01
NR1H2 and NR1H3-mediated signaling 44 4.36e-02 -0.176000 5.01e-01
RHO GTPases activate CIT 18 1.97e-01 -0.176000 6.82e-01
Carnitine metabolism 11 3.13e-01 -0.176000 7.39e-01
Caspase activation via extrinsic apoptotic signalling pathway 24 1.37e-01 0.175000 6.63e-01
Gamma-carboxylation of protein precursors 10 3.38e-01 -0.175000 7.61e-01
Pregnenolone biosynthesis 10 3.39e-01 -0.175000 7.61e-01
RAS processing 17 2.13e-01 0.174000 6.93e-01
Synthesis of PIPs at the early endosome membrane 15 2.43e-01 0.174000 7.09e-01
FRS-mediated FGFR3 signaling 19 1.89e-01 0.174000 6.82e-01
DNA strand elongation 26 1.27e-01 -0.173000 6.43e-01
Inhibition of DNA recombination at telomere 13 2.81e-01 -0.173000 7.27e-01
Glycogen storage diseases 11 3.22e-01 -0.173000 7.46e-01
Pre-NOTCH Expression and Processing 46 4.30e-02 -0.173000 5.01e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 14 2.64e-01 0.172000 7.16e-01
RNA Polymerase I Transcription 40 5.97e-02 -0.172000 5.58e-01
Adenylate cyclase inhibitory pathway 14 2.65e-01 0.172000 7.17e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.02e-01 0.172000 7.37e-01
Serotonin receptors 11 3.25e-01 0.171000 7.49e-01
SHC1 events in ERBB2 signaling 22 1.65e-01 0.171000 6.77e-01
Synthesis of PIPs at the Golgi membrane 17 2.23e-01 0.171000 6.94e-01
HS-GAG biosynthesis 26 1.32e-01 0.171000 6.51e-01
RNA Polymerase I Promoter Clearance 39 6.58e-02 -0.170000 5.62e-01
Trafficking of GluR2-containing AMPA receptors 15 2.54e-01 -0.170000 7.11e-01
Synthesis of IP2, IP, and Ins in the cytosol 14 2.70e-01 -0.170000 7.26e-01
Negative regulation of FGFR3 signaling 26 1.34e-01 0.170000 6.59e-01
RUNX2 regulates bone development 30 1.09e-01 0.169000 6.34e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 8.02e-02 -0.169000 6.10e-01
NCAM1 interactions 35 8.54e-02 -0.168000 6.23e-01
Signaling by FGFR 73 1.31e-02 0.168000 4.21e-01
Resolution of Abasic Sites (AP sites) 31 1.06e-01 -0.168000 6.34e-01
GABA receptor activation 52 3.66e-02 0.168000 4.71e-01
TICAM1, RIP1-mediated IKK complex recruitment 13 2.96e-01 0.167000 7.32e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 34 9.62e-02 -0.165000 6.34e-01
Activation of NMDA receptors and postsynaptic events 72 1.59e-02 0.164000 4.21e-01
Initial triggering of complement 27 1.40e-01 -0.164000 6.70e-01
SHC-mediated cascade:FGFR2 23 1.74e-01 0.164000 6.82e-01
Positive epigenetic regulation of rRNA expression 36 9.00e-02 -0.163000 6.23e-01
Signaling by ERBB4 52 4.23e-02 0.163000 5.01e-01
Cyclin A/B1/B2 associated events during G2/M transition 21 1.97e-01 0.163000 6.82e-01
Signaling by Non-Receptor Tyrosine Kinases 47 5.36e-02 0.163000 5.31e-01
Signaling by PTK6 47 5.36e-02 0.163000 5.31e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 28 1.36e-01 -0.163000 6.62e-01
Regulation of RUNX3 expression and activity 43 6.58e-02 -0.162000 5.62e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 47 5.50e-02 -0.162000 5.31e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 35 9.80e-02 -0.162000 6.34e-01
Meiotic synapsis 30 1.26e-01 -0.161000 6.42e-01
RNA Polymerase I Transcription Initiation 36 9.40e-02 -0.161000 6.34e-01
FRS-mediated FGFR2 signaling 24 1.72e-01 0.161000 6.82e-01
Glycosphingolipid metabolism 36 9.49e-02 -0.161000 6.34e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 3.16e-01 -0.161000 7.39e-01
Glycerophospholipid biosynthesis 104 4.71e-03 -0.161000 2.97e-01
Negative regulation of FGFR2 signaling 31 1.22e-01 0.160000 6.39e-01
Insulin processing 22 1.93e-01 0.160000 6.82e-01
SUMOylation of transcription factors 16 2.67e-01 -0.160000 7.20e-01
Metal ion SLC transporters 21 2.05e-01 -0.160000 6.87e-01
Formation of the beta-catenin:TCF transactivating complex 30 1.30e-01 -0.160000 6.44e-01
Regulation of gene expression in beta cells 18 2.41e-01 0.160000 7.09e-01
Bicarbonate transporters 10 3.83e-01 -0.159000 7.82e-01
Plasma lipoprotein clearance 32 1.19e-01 -0.159000 6.34e-01
DAP12 signaling 26 1.61e-01 0.159000 6.75e-01
Signaling by FGFR4 36 9.90e-02 0.159000 6.34e-01
Plasma lipoprotein remodeling 28 1.48e-01 -0.158000 6.74e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 12 3.45e-01 0.158000 7.62e-01
TRAF6 mediated NF-kB activation 20 2.24e-01 -0.157000 6.94e-01
FGFR2 ligand binding and activation 19 2.36e-01 0.157000 7.09e-01
Retrograde transport at the Trans-Golgi-Network 41 8.34e-02 0.156000 6.20e-01
Base Excision Repair 37 1.02e-01 -0.155000 6.34e-01
PI-3K cascade:FGFR3 18 2.55e-01 0.155000 7.11e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 18 2.57e-01 0.154000 7.11e-01
Basigin interactions 24 1.91e-01 -0.154000 6.82e-01
MAPK targets/ Nuclear events mediated by MAP kinases 30 1.44e-01 0.154000 6.70e-01
PCNA-Dependent Long Patch Base Excision Repair 17 2.73e-01 -0.154000 7.27e-01
Platelet Adhesion to exposed collagen 13 3.39e-01 0.153000 7.61e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 2.48e-01 0.153000 7.11e-01
Synaptic adhesion-like molecules 21 2.25e-01 -0.153000 6.94e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 29 1.54e-01 -0.153000 6.75e-01
Gap junction trafficking 24 1.95e-01 -0.153000 6.82e-01
Fatty acids 11 3.84e-01 0.152000 7.82e-01
Notch-HLH transcription pathway 24 1.98e-01 -0.152000 6.82e-01
Organic cation/anion/zwitterion transport 14 3.26e-01 -0.152000 7.49e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 27 1.73e-01 -0.152000 6.82e-01
Signaling by Retinoic Acid 40 9.72e-02 -0.152000 6.34e-01
AKT phosphorylates targets in the cytosol 13 3.44e-01 -0.152000 7.62e-01
Response of Mtb to phagocytosis 20 2.42e-01 0.151000 7.09e-01
Integrin cell surface interactions 61 4.18e-02 -0.151000 5.01e-01
PKA activation 17 2.85e-01 0.150000 7.27e-01
Gap junction trafficking and regulation 26 1.86e-01 -0.150000 6.82e-01
Activation of gene expression by SREBF (SREBP) 39 1.07e-01 -0.149000 6.34e-01
Glucose metabolism 77 2.38e-02 -0.149000 4.21e-01
DNA Double Strand Break Response 36 1.25e-01 -0.148000 6.42e-01
Resolution of D-Loop Structures 29 1.68e-01 -0.148000 6.82e-01
Reduction of cytosolic Ca++ levels 12 3.75e-01 0.148000 7.82e-01
Suppression of phagosomal maturation 10 4.19e-01 0.148000 7.95e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 38 1.16e-01 0.147000 6.34e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 30 1.63e-01 -0.147000 6.75e-01
HIV Transcription Elongation 30 1.63e-01 -0.147000 6.75e-01
Tat-mediated elongation of the HIV-1 transcript 30 1.63e-01 -0.147000 6.75e-01
Processing of Intronless Pre-mRNAs 12 3.78e-01 0.147000 7.82e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 2.82e-01 -0.146000 7.27e-01
NRAGE signals death through JNK 58 5.44e-02 -0.146000 5.31e-01
Platelet sensitization by LDL 16 3.12e-01 -0.146000 7.39e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 62 4.72e-02 0.146000 5.01e-01
Class I peroxisomal membrane protein import 16 3.13e-01 0.146000 7.39e-01
Platelet Aggregation (Plug Formation) 37 1.25e-01 -0.146000 6.42e-01
PI-3K cascade:FGFR2 23 2.27e-01 0.146000 6.97e-01
Downstream signaling of activated FGFR1 30 1.69e-01 0.145000 6.82e-01
Assembly and cell surface presentation of NMDA receptors 24 2.19e-01 0.145000 6.93e-01
Assembly of active LPL and LIPC lipase complexes 18 2.88e-01 -0.145000 7.27e-01
Autodegradation of Cdh1 by Cdh1:APC/C 51 7.44e-02 -0.144000 5.99e-01
Cyclin D associated events in G1 41 1.11e-01 0.144000 6.34e-01
G1 Phase 41 1.11e-01 0.144000 6.34e-01
COPI-dependent Golgi-to-ER retrograde traffic 72 3.48e-02 -0.144000 4.69e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 28 1.88e-01 -0.144000 6.82e-01
Trafficking of AMPA receptors 28 1.88e-01 -0.144000 6.82e-01
Cell death signalling via NRAGE, NRIF and NADE 68 4.03e-02 -0.144000 5.01e-01
HDMs demethylate histones 19 2.78e-01 0.144000 7.27e-01
Non-integrin membrane-ECM interactions 38 1.26e-01 -0.143000 6.42e-01
DAP12 interactions 32 1.63e-01 0.142000 6.75e-01
Aquaporin-mediated transport 45 9.93e-02 -0.142000 6.34e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 12 3.94e-01 0.142000 7.84e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 15 3.42e-01 0.142000 7.61e-01
RUNX2 regulates osteoblast differentiation 24 2.31e-01 0.141000 7.03e-01
Mitochondrial calcium ion transport 17 3.14e-01 -0.141000 7.39e-01
Surfactant metabolism 21 2.64e-01 -0.141000 7.16e-01
EPHA-mediated growth cone collapse 14 3.62e-01 -0.141000 7.71e-01
Phase II - Conjugation of compounds 87 2.40e-02 0.140000 4.21e-01
Activated NOTCH1 Transmits Signal to the Nucleus 24 2.37e-01 -0.139000 7.09e-01
Signaling by BMP 26 2.19e-01 0.139000 6.93e-01
Telomere Extension By Telomerase 20 2.82e-01 0.139000 7.27e-01
Signaling by NTRK2 (TRKB) 24 2.39e-01 0.139000 7.09e-01
Voltage gated Potassium channels 41 1.24e-01 0.139000 6.42e-01
Apoptotic cleavage of cellular proteins 35 1.56e-01 0.139000 6.75e-01
CD28 dependent Vav1 pathway 12 4.07e-01 0.138000 7.88e-01
Hyaluronan metabolism 15 3.54e-01 -0.138000 7.68e-01
Stabilization of p53 44 1.13e-01 -0.138000 6.34e-01
FCERI mediated Ca+2 mobilization 30 1.92e-01 0.138000 6.82e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 2.16e-01 -0.138000 6.93e-01
rRNA modification in the nucleus and cytosol 47 1.04e-01 -0.137000 6.34e-01
Extra-nuclear estrogen signaling 69 4.90e-02 0.137000 5.07e-01
Signaling by FGFR2 IIIa TM 12 4.11e-01 -0.137000 7.92e-01
Synthesis of IP3 and IP4 in the cytosol 23 2.57e-01 -0.137000 7.11e-01
MAP kinase activation 57 7.60e-02 0.136000 5.99e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 39 1.45e-01 -0.135000 6.70e-01
Glucocorticoid biosynthesis 10 4.61e-01 0.135000 8.24e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 4.39e-01 0.135000 8.10e-01
RNA Polymerase II Transcription Termination 49 1.03e-01 0.135000 6.34e-01
PCP/CE pathway 77 4.17e-02 -0.134000 5.01e-01
Metabolism of steroid hormones 31 1.96e-01 -0.134000 6.82e-01
Interleukin-27 signaling 11 4.42e-01 -0.134000 8.13e-01
Integrin signaling 27 2.29e-01 -0.134000 6.98e-01
FGFR3 ligand binding and activation 13 4.05e-01 0.134000 7.88e-01
FGFR3c ligand binding and activation 13 4.05e-01 0.134000 7.88e-01
Transcription of E2F targets under negative control by DREAM complex 17 3.41e-01 -0.133000 7.61e-01
HDR through Single Strand Annealing (SSA) 31 2.00e-01 -0.133000 6.82e-01
Elevation of cytosolic Ca2+ levels 14 3.89e-01 -0.133000 7.84e-01
DCC mediated attractive signaling 14 3.91e-01 0.133000 7.84e-01
Meiosis 52 9.84e-02 -0.133000 6.34e-01
Activation of Ca-permeable Kainate Receptor 10 4.70e-01 0.132000 8.30e-01
Ionotropic activity of kainate receptors 10 4.70e-01 0.132000 8.30e-01
Unfolded Protein Response (UPR) 79 4.31e-02 -0.132000 5.01e-01
Phospholipase C-mediated cascade; FGFR3 13 4.12e-01 0.131000 7.92e-01
HSF1 activation 21 2.98e-01 -0.131000 7.34e-01
Signaling by FGFR2 in disease 36 1.74e-01 0.131000 6.82e-01
Metabolism of amino acids and derivatives 285 1.68e-04 -0.130000 2.33e-02
Downregulation of ERBB2 signaling 23 2.82e-01 0.130000 7.27e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 18 3.41e-01 -0.130000 7.61e-01
p75 NTR receptor-mediated signalling 84 4.07e-02 -0.129000 5.01e-01
Regulation of TP53 Activity 141 8.43e-03 -0.129000 3.74e-01
Prostacyclin signalling through prostacyclin receptor 14 4.07e-01 -0.128000 7.88e-01
Chondroitin sulfate biosynthesis 20 3.22e-01 0.128000 7.46e-01
Transcriptional regulation of granulopoiesis 31 2.18e-01 -0.128000 6.93e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 60 8.69e-02 -0.128000 6.23e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 31 2.21e-01 -0.127000 6.94e-01
Nucleotide salvage 19 3.42e-01 -0.126000 7.61e-01
PKMTs methylate histone lysines 35 1.98e-01 -0.126000 6.82e-01
G alpha (12/13) signalling events 72 6.49e-02 -0.126000 5.62e-01
Phospholipase C-mediated cascade; FGFR2 18 3.56e-01 0.126000 7.68e-01
FCGR3A-mediated IL10 synthesis 44 1.50e-01 0.125000 6.74e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 3.45e-01 -0.125000 7.62e-01
Apoptotic execution phase 42 1.61e-01 0.125000 6.75e-01
Interferon gamma signaling 66 7.94e-02 -0.125000 6.10e-01
Synthesis, secretion, and deacylation of Ghrelin 17 3.73e-01 0.125000 7.82e-01
Infection with Mycobacterium tuberculosis 24 2.90e-01 0.125000 7.27e-01
Meiotic recombination 24 2.92e-01 -0.124000 7.30e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 4.06e-01 0.124000 7.88e-01
Cross-presentation of soluble exogenous antigens (endosomes) 42 1.66e-01 -0.124000 6.77e-01
Activation of SMO 14 4.24e-01 -0.123000 7.97e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 81 5.53e-02 -0.123000 5.31e-01
Erythropoietin activates RAS 13 4.46e-01 0.122000 8.13e-01
Diseases associated with O-glycosylation of proteins 57 1.12e-01 -0.122000 6.34e-01
Formation of HIV elongation complex in the absence of HIV Tat 31 2.43e-01 -0.121000 7.09e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 20 3.49e-01 -0.121000 7.68e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 42 1.76e-01 -0.121000 6.82e-01
Downregulation of TGF-beta receptor signaling 20 3.50e-01 0.121000 7.68e-01
Downstream signaling of activated FGFR4 25 2.98e-01 0.120000 7.34e-01
mRNA decay by 5' to 3' exoribonuclease 13 4.53e-01 -0.120000 8.18e-01
Transport of vitamins, nucleosides, and related molecules 37 2.07e-01 -0.120000 6.87e-01
Autophagy 108 3.18e-02 -0.120000 4.51e-01
Macroautophagy 95 4.42e-02 -0.120000 5.01e-01
ADP signalling through P2Y purinoceptor 12 17 3.94e-01 0.120000 7.84e-01
ERKs are inactivated 13 4.56e-01 -0.119000 8.20e-01
Myogenesis 27 2.83e-01 0.119000 7.27e-01
Blood group systems biosynthesis 15 4.24e-01 -0.119000 7.97e-01
Assembly Of The HIV Virion 11 4.93e-01 -0.119000 8.47e-01
Laminin interactions 23 3.23e-01 -0.119000 7.47e-01
Translesion synthesis by POLI 13 4.57e-01 -0.119000 8.21e-01
Asymmetric localization of PCP proteins 53 1.35e-01 -0.119000 6.62e-01
Autodegradation of the E3 ubiquitin ligase COP1 41 1.90e-01 -0.118000 6.82e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 20 3.60e-01 -0.118000 7.70e-01
APC/C:Cdc20 mediated degradation of Securin 55 1.30e-01 -0.118000 6.44e-01
Transcriptional regulation by RUNX3 82 6.56e-02 -0.118000 5.62e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 4.30e-01 -0.118000 8.04e-01
Translesion synthesis by REV1 12 4.81e-01 -0.118000 8.42e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 19 3.75e-01 -0.117000 7.82e-01
Plasma lipoprotein assembly, remodeling, and clearance 63 1.09e-01 -0.117000 6.34e-01
Elastic fibre formation 37 2.20e-01 -0.116000 6.94e-01
p38MAPK events 13 4.67e-01 -0.116000 8.28e-01
HSF1-dependent transactivation 28 2.87e-01 -0.116000 7.27e-01
Chromatin modifying enzymes 173 8.61e-03 -0.116000 3.74e-01
Chromatin organization 173 8.61e-03 -0.116000 3.74e-01
Defective B3GAT3 causes JDSSDHD 19 3.83e-01 0.116000 7.82e-01
Tryptophan catabolism 12 4.90e-01 -0.115000 8.44e-01
Phase 2 - plateau phase 21 3.62e-01 -0.115000 7.70e-01
Interleukin receptor SHC signaling 24 3.30e-01 -0.115000 7.52e-01
Mitochondrial tRNA aminoacylation 15 4.43e-01 -0.114000 8.13e-01
Unblocking of NMDA receptors, glutamate binding and activation 20 3.78e-01 0.114000 7.82e-01
Hh mutants abrogate ligand secretion 45 1.87e-01 -0.114000 6.82e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 60 1.28e-01 -0.114000 6.43e-01
Ca-dependent events 33 2.59e-01 0.114000 7.11e-01
G beta:gamma signalling through CDC42 15 4.47e-01 0.113000 8.13e-01
CS/DS degradation 14 4.64e-01 0.113000 8.25e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 4.06e-01 0.113000 7.88e-01
mRNA 3'-end processing 42 2.06e-01 0.113000 6.87e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 4.51e-01 -0.112000 8.16e-01
HDR through Homologous Recombination (HRR) 53 1.57e-01 -0.112000 6.75e-01
Post NMDA receptor activation events 59 1.36e-01 0.112000 6.62e-01
Cell surface interactions at the vascular wall 131 2.67e-02 -0.112000 4.21e-01
Glycogen synthesis 12 5.01e-01 0.112000 8.51e-01
Regulation of TP53 Activity through Phosphorylation 79 8.58e-02 -0.112000 6.23e-01
PERK regulates gene expression 26 3.24e-01 0.112000 7.49e-01
MHC class II antigen presentation 95 6.16e-02 -0.111000 5.61e-01
Organic anion transporters 10 5.44e-01 -0.111000 8.70e-01
Growth hormone receptor signaling 21 3.80e-01 -0.111000 7.82e-01
Visual phototransduction 88 7.31e-02 -0.111000 5.98e-01
Keratan sulfate/keratin metabolism 28 3.12e-01 -0.110000 7.39e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 15 4.60e-01 -0.110000 8.24e-01
Beta-catenin phosphorylation cascade 16 4.48e-01 0.110000 8.13e-01
Keratan sulfate biosynthesis 24 3.53e-01 -0.110000 7.68e-01
mTORC1-mediated signalling 20 3.97e-01 0.109000 7.85e-01
Heme degradation 15 4.64e-01 0.109000 8.25e-01
ABC transporter disorders 60 1.45e-01 -0.109000 6.70e-01
Peptide hormone metabolism 77 9.95e-02 0.109000 6.34e-01
Cytochrome P450 - arranged by substrate type 56 1.60e-01 0.109000 6.75e-01
Ribosomal scanning and start codon recognition 32 2.89e-01 0.108000 7.27e-01
TBC/RABGAPs 37 2.55e-01 -0.108000 7.11e-01
Defective B4GALT7 causes EDS, progeroid type 19 4.15e-01 0.108000 7.94e-01
Chemokine receptors bind chemokines 47 2.01e-01 0.108000 6.82e-01
Oncogene Induced Senescence 29 3.15e-01 0.108000 7.39e-01
Misspliced GSK3beta mutants stabilize beta-catenin 14 4.85e-01 0.108000 8.42e-01
S33 mutants of beta-catenin aren't phosphorylated 14 4.85e-01 0.108000 8.42e-01
S37 mutants of beta-catenin aren't phosphorylated 14 4.85e-01 0.108000 8.42e-01
S45 mutants of beta-catenin aren't phosphorylated 14 4.85e-01 0.108000 8.42e-01
T41 mutants of beta-catenin aren't phosphorylated 14 4.85e-01 0.108000 8.42e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 4.85e-01 0.108000 8.42e-01
RUNX3 regulates NOTCH signaling 13 5.02e-01 0.108000 8.51e-01
p53-Dependent G1 DNA Damage Response 53 1.76e-01 -0.107000 6.82e-01
p53-Dependent G1/S DNA damage checkpoint 53 1.76e-01 -0.107000 6.82e-01
Degradation of DVL 46 2.09e-01 -0.107000 6.87e-01
LDL clearance 19 4.20e-01 -0.107000 7.95e-01
Formation of the Early Elongation Complex 25 3.55e-01 -0.107000 7.68e-01
Formation of the HIV-1 Early Elongation Complex 25 3.55e-01 -0.107000 7.68e-01
Vpu mediated degradation of CD4 41 2.38e-01 -0.106000 7.09e-01
NOD1/2 Signaling Pathway 28 3.29e-01 0.106000 7.52e-01
ABC-family proteins mediated transport 81 9.88e-02 -0.106000 6.34e-01
Regulation of TP53 Degradation 31 3.07e-01 -0.106000 7.39e-01
Long-term potentiation 22 3.90e-01 0.106000 7.84e-01
Activated point mutants of FGFR2 17 4.51e-01 0.106000 8.16e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 14 4.95e-01 -0.105000 8.49e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 5.12e-01 -0.105000 8.57e-01
Constitutive Signaling by Overexpressed ERBB2 10 5.65e-01 0.105000 8.73e-01
Mitochondrial protein import 50 2.00e-01 -0.105000 6.82e-01
Recognition of DNA damage by PCNA-containing replication complex 22 3.97e-01 -0.104000 7.85e-01
DNA Double-Strand Break Repair 108 6.12e-02 -0.104000 5.61e-01
Intrinsic Pathway of Fibrin Clot Formation 21 4.09e-01 -0.104000 7.90e-01
SLC-mediated transmembrane transport 227 6.95e-03 -0.104000 3.74e-01
TP53 Regulates Transcription of DNA Repair Genes 48 2.12e-01 -0.104000 6.93e-01
Pre-NOTCH Transcription and Translation 33 3.01e-01 -0.104000 7.34e-01
Regulation of MECP2 expression and activity 26 3.59e-01 0.104000 7.70e-01
Regulation of FZD by ubiquitination 17 4.60e-01 0.104000 8.24e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.56e-01 -0.103000 6.75e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.56e-01 -0.103000 6.75e-01
FGFR3 mutant receptor activation 12 5.35e-01 0.103000 8.70e-01
Signaling by activated point mutants of FGFR3 12 5.35e-01 0.103000 8.70e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 32 3.12e-01 0.103000 7.39e-01
Peroxisomal protein import 54 1.89e-01 -0.103000 6.82e-01
Translation initiation complex formation 31 3.20e-01 0.103000 7.45e-01
RNA Polymerase III Chain Elongation 13 5.19e-01 -0.103000 8.61e-01
Vif-mediated degradation of APOBEC3G 40 2.60e-01 -0.103000 7.11e-01
Homology Directed Repair 85 1.01e-01 -0.103000 6.34e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 3.84e-01 -0.103000 7.82e-01
Neurotransmitter receptors and postsynaptic signal transmission 169 2.16e-02 0.103000 4.21e-01
Interleukin-2 family signaling 40 2.63e-01 -0.102000 7.16e-01
Diseases of glycosylation 127 4.69e-02 -0.102000 5.01e-01
Activation of BAD and translocation to mitochondria 14 5.08e-01 0.102000 8.57e-01
Golgi Cisternae Pericentriolar Stack Reorganization 12 5.40e-01 -0.102000 8.70e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 5.57e-01 0.102000 8.70e-01
EPHB-mediated forward signaling 32 3.18e-01 0.102000 7.43e-01
Signaling by Hippo 19 4.42e-01 0.102000 8.13e-01
Prefoldin mediated transfer of substrate to CCT/TriC 23 3.98e-01 -0.102000 7.86e-01
TRAF3-dependent IRF activation pathway 14 5.11e-01 -0.102000 8.57e-01
Regulation of ornithine decarboxylase (ODC) 43 2.50e-01 -0.102000 7.11e-01
Reversible hydration of carbon dioxide 12 5.43e-01 0.101000 8.70e-01
Regulation of HSF1-mediated heat shock response 58 1.82e-01 0.101000 6.82e-01
Metabolism of non-coding RNA 39 2.73e-01 0.101000 7.27e-01
snRNP Assembly 39 2.73e-01 0.101000 7.27e-01
Formation of the cornified envelope 43 2.52e-01 0.101000 7.11e-01
Degradation of AXIN 43 2.52e-01 -0.101000 7.11e-01
Signaling by TGFB family members 87 1.04e-01 0.101000 6.34e-01
Signalling to ERKs 34 3.10e-01 0.101000 7.39e-01
Telomere Maintenance 52 2.10e-01 -0.101000 6.87e-01
CDK-mediated phosphorylation and removal of Cdc6 60 1.78e-01 -0.100000 6.82e-01
Negative regulators of DDX58/IFIH1 signaling 25 3.85e-01 -0.100000 7.82e-01
Activation of the TFAP2 (AP-2) family of transcription factors 11 5.65e-01 0.100000 8.73e-01
Phosphorylation of the APC/C 17 4.75e-01 -0.100000 8.35e-01
Negative regulation of NOTCH4 signaling 43 2.59e-01 -0.099500 7.11e-01
Interleukin-17 signaling 64 1.71e-01 0.098900 6.82e-01
Inositol phosphate metabolism 45 2.51e-01 -0.098900 7.11e-01
Free fatty acids regulate insulin secretion 11 5.70e-01 -0.098900 8.78e-01
Regulation of Apoptosis 41 2.77e-01 -0.098200 7.27e-01
Metabolism of Angiotensinogen to Angiotensins 16 4.98e-01 0.097900 8.49e-01
Regulation of TP53 Activity through Association with Co-factors 14 5.26e-01 -0.097800 8.66e-01
TGF-beta receptor signaling activates SMADs 23 4.19e-01 0.097500 7.95e-01
Glutathione conjugation 30 3.57e-01 -0.097200 7.68e-01
Molecules associated with elastic fibres 29 3.65e-01 -0.097200 7.74e-01
Translesion synthesis by POLK 13 5.45e-01 -0.097000 8.70e-01
Negative regulation of FGFR4 signaling 27 3.84e-01 0.096800 7.82e-01
Biological oxidations 183 2.47e-02 0.096400 4.21e-01
Hedgehog ligand biogenesis 51 2.34e-01 -0.096400 7.09e-01
Diseases of metabolism 212 1.58e-02 -0.096300 4.21e-01
Dissolution of Fibrin Clot 13 5.49e-01 0.096100 8.70e-01
Negative regulation of FGFR1 signaling 29 3.71e-01 0.096100 7.82e-01
Stimuli-sensing channels 89 1.18e-01 0.096000 6.34e-01
TP53 Regulates Transcription of Cell Death Genes 36 3.19e-01 0.095900 7.45e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 101 9.61e-02 -0.095900 6.34e-01
p130Cas linkage to MAPK signaling for integrins 15 5.20e-01 -0.095900 8.61e-01
DNA Damage Bypass 35 3.27e-01 -0.095700 7.50e-01
Phospholipid metabolism 183 2.59e-02 -0.095600 4.21e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 50 2.43e-01 -0.095500 7.09e-01
Thromboxane signalling through TP receptor 18 4.83e-01 -0.095500 8.42e-01
Integration of energy metabolism 100 1.01e-01 -0.095000 6.34e-01
RHO GTPases activate IQGAPs 11 5.86e-01 0.094900 8.84e-01
PECAM1 interactions 11 5.86e-01 -0.094800 8.84e-01
CDT1 association with the CDC6:ORC:origin complex 46 2.66e-01 -0.094800 7.17e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 3.94e-01 0.094800 7.84e-01
Metabolism of fat-soluble vitamins 39 3.06e-01 -0.094800 7.39e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 40 3.00e-01 -0.094600 7.34e-01
p53-Independent DNA Damage Response 40 3.00e-01 -0.094600 7.34e-01
p53-Independent G1/S DNA damage checkpoint 40 3.00e-01 -0.094600 7.34e-01
Ubiquitin-dependent degradation of Cyclin D 41 2.95e-01 -0.094600 7.32e-01
AMER1 mutants destabilize the destruction complex 13 5.55e-01 0.094600 8.70e-01
APC truncation mutants have impaired AXIN binding 13 5.55e-01 0.094600 8.70e-01
AXIN missense mutants destabilize the destruction complex 13 5.55e-01 0.094600 8.70e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 5.55e-01 0.094600 8.70e-01
Truncations of AMER1 destabilize the destruction complex 13 5.55e-01 0.094600 8.70e-01
truncated APC mutants destabilize the destruction complex 13 5.55e-01 0.094600 8.70e-01
The role of Nef in HIV-1 replication and disease pathogenesis 26 4.05e-01 -0.094400 7.88e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 36 3.27e-01 -0.094400 7.50e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 67 1.83e-01 0.094200 6.82e-01
Nonsense-Mediated Decay (NMD) 67 1.83e-01 0.094200 6.82e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 78 1.51e-01 0.094100 6.74e-01
Formation of the ternary complex, and subsequently, the 43S complex 28 3.89e-01 0.094000 7.84e-01
Heparan sulfate/heparin (HS-GAG) metabolism 48 2.60e-01 0.094000 7.11e-01
Insulin receptor recycling 23 4.36e-01 0.093900 8.08e-01
Circadian Clock 62 2.02e-01 0.093800 6.83e-01
FGFR2c ligand binding and activation 13 5.58e-01 0.093800 8.70e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 2.10e-01 -0.093600 6.87e-01
Glycolysis 59 2.15e-01 -0.093400 6.93e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 2.08e-01 -0.093200 6.87e-01
UCH proteinases 69 1.81e-01 -0.093100 6.82e-01
P2Y receptors 10 6.11e-01 0.093000 8.98e-01
Synthesis of bile acids and bile salts 28 3.95e-01 -0.092900 7.84e-01
Role of phospholipids in phagocytosis 30 3.79e-01 -0.092900 7.82e-01
Regulation of TNFR1 signaling 26 4.12e-01 -0.092900 7.92e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 4.04e-01 -0.092900 7.88e-01
O-linked glycosylation of mucins 54 2.38e-01 -0.092800 7.09e-01
FOXO-mediated transcription 60 2.14e-01 0.092800 6.93e-01
Disorders of transmembrane transporters 146 5.33e-02 -0.092800 5.31e-01
Signaling by FGFR1 in disease 37 3.31e-01 0.092400 7.52e-01
GAB1 signalosome 17 5.10e-01 0.092200 8.57e-01
Response of EIF2AK1 (HRI) to heme deficiency 12 5.80e-01 0.092200 8.83e-01
Inwardly rectifying K+ channels 30 3.83e-01 -0.092100 7.82e-01
DNA Replication Pre-Initiation 68 1.89e-01 -0.092100 6.82e-01
TNFR1-induced proapoptotic signaling 13 5.66e-01 -0.092000 8.74e-01
Presynaptic depolarization and calcium channel opening 12 5.81e-01 -0.091900 8.83e-01
TP53 Regulates Transcription of Cell Cycle Genes 46 2.81e-01 -0.091800 7.27e-01
MyD88 dependent cascade initiated on endosome 79 1.59e-01 0.091700 6.75e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 79 1.59e-01 0.091700 6.75e-01
Regulation of PTEN gene transcription 55 2.41e-01 -0.091500 7.09e-01
Metabolism of polyamines 50 2.65e-01 -0.091200 7.16e-01
Nucleotide-like (purinergic) receptors 13 5.70e-01 0.091100 8.78e-01
Miscellaneous transport and binding events 22 4.61e-01 0.090800 8.24e-01
The phototransduction cascade 30 3.90e-01 -0.090700 7.84e-01
Ovarian tumor domain proteases 30 3.90e-01 0.090600 7.84e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 4.42e-01 -0.090600 8.13e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 44 2.99e-01 -0.090500 7.34e-01
tRNA processing 84 1.57e-01 -0.089300 6.75e-01
Retinoid metabolism and transport 37 3.49e-01 -0.089000 7.68e-01
activated TAK1 mediates p38 MAPK activation 17 5.26e-01 0.088800 8.66e-01
Presynaptic nicotinic acetylcholine receptors 12 5.95e-01 -0.088600 8.90e-01
Metabolism of steroids 130 8.28e-02 -0.088200 6.20e-01
Toll Like Receptor 9 (TLR9) Cascade 82 1.69e-01 0.088000 6.82e-01
Metabolism of nucleotides 87 1.57e-01 -0.087900 6.75e-01
Cargo concentration in the ER 25 4.47e-01 -0.087900 8.13e-01
G1/S DNA Damage Checkpoints 55 2.61e-01 -0.087600 7.13e-01
SCF-beta-TrCP mediated degradation of Emi1 44 3.15e-01 -0.087500 7.39e-01
Cytosolic sensors of pathogen-associated DNA 49 2.90e-01 -0.087400 7.27e-01
Asparagine N-linked glycosylation 239 2.03e-02 -0.087300 4.21e-01
Beta-catenin independent WNT signaling 125 9.25e-02 -0.087200 6.34e-01
Mitochondrial biogenesis 67 2.18e-01 -0.087200 6.93e-01
Formation of tubulin folding intermediates by CCT/TriC 21 4.90e-01 -0.087100 8.44e-01
Diseases associated with N-glycosylation of proteins 16 5.47e-01 -0.087100 8.70e-01
Extracellular matrix organization 268 1.45e-02 -0.086900 4.21e-01
Phase I - Functionalization of compounds 92 1.50e-01 0.086800 6.74e-01
RIP-mediated NFkB activation via ZBP1 15 5.63e-01 -0.086300 8.72e-01
Metabolism of water-soluble vitamins and cofactors 99 1.38e-01 -0.086300 6.65e-01
Translesion Synthesis by POLH 12 6.06e-01 -0.085900 8.96e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 43 3.32e-01 -0.085500 7.52e-01
Metabolism of carbohydrates 252 1.97e-02 -0.085500 4.21e-01
Factors involved in megakaryocyte development and platelet production 119 1.08e-01 0.085400 6.34e-01
PRC2 methylates histones and DNA 12 6.09e-01 0.085300 8.96e-01
BBSome-mediated cargo-targeting to cilium 19 5.20e-01 0.085300 8.61e-01
Rho GTPase cycle 131 9.31e-02 -0.085000 6.34e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 30 4.21e-01 0.084900 7.95e-01
Tandem pore domain potassium channels 11 6.27e-01 0.084700 9.04e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 5.84e-01 0.084600 8.84e-01
Inactivation, recovery and regulation of the phototransduction cascade 29 4.31e-01 -0.084500 8.04e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 5.85e-01 -0.084200 8.84e-01
Assembly of the pre-replicative complex 54 2.85e-01 -0.084200 7.27e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 49 3.12e-01 0.083500 7.39e-01
Interleukin-12 signaling 38 3.73e-01 0.083500 7.82e-01
Gene Silencing by RNA 56 2.80e-01 -0.083500 7.27e-01
Degradation of the extracellular matrix 100 1.50e-01 -0.083400 6.74e-01
NS1 Mediated Effects on Host Pathways 29 4.39e-01 0.083100 8.10e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 20 5.20e-01 -0.083100 8.61e-01
Defective CFTR causes cystic fibrosis 46 3.32e-01 -0.082800 7.52e-01
MAPK6/MAPK4 signaling 75 2.16e-01 -0.082700 6.93e-01
Fatty acid metabolism 148 8.29e-02 -0.082700 6.20e-01
Metabolism of vitamins and cofactors 156 7.51e-02 -0.082700 5.99e-01
Regulation of TP53 Expression and Degradation 32 4.19e-01 -0.082500 7.95e-01
Phosphorylation of CD3 and TCR zeta chains 15 5.81e-01 -0.082300 8.83e-01
PLC beta mediated events 49 3.21e-01 0.082000 7.46e-01
Signaling by ERBB2 43 3.53e-01 0.081900 7.68e-01
Homologous DNA Pairing and Strand Exchange 36 3.95e-01 -0.081900 7.84e-01
Extension of Telomeres 43 3.53e-01 -0.081800 7.68e-01
Interleukin-37 signaling 19 5.38e-01 -0.081700 8.70e-01
Binding and Uptake of Ligands by Scavenger Receptors 40 3.72e-01 -0.081600 7.82e-01
Transport of Ribonucleoproteins into the Host Nucleus 23 4.98e-01 0.081600 8.49e-01
Mitochondrial translation elongation 64 2.60e-01 -0.081500 7.11e-01
Mitochondrial translation 70 2.41e-01 -0.081100 7.09e-01
Golgi-to-ER retrograde transport 104 1.54e-01 -0.081000 6.75e-01
SLC transporter disorders 86 1.96e-01 -0.080800 6.82e-01
DNA Replication 107 1.51e-01 -0.080500 6.74e-01
APC/C:Cdc20 mediated degradation of Cyclin B 19 5.44e-01 -0.080400 8.70e-01
Transcriptional regulation by RUNX2 104 1.57e-01 0.080300 6.75e-01
Regulation of lipid metabolism by PPARalpha 110 1.46e-01 0.080300 6.70e-01
Antigen processing-Cross presentation 77 2.24e-01 -0.080300 6.94e-01
RET signaling 38 3.92e-01 -0.080200 7.84e-01
ADP signalling through P2Y purinoceptor 1 20 5.35e-01 -0.080100 8.70e-01
Caspase-mediated cleavage of cytoskeletal proteins 11 6.46e-01 -0.080100 9.17e-01
Constitutive Signaling by AKT1 E17K in Cancer 24 4.99e-01 -0.079800 8.49e-01
APC/C-mediated degradation of cell cycle proteins 74 2.37e-01 -0.079600 7.09e-01
Regulation of mitotic cell cycle 74 2.37e-01 -0.079600 7.09e-01
Deposition of new CENPA-containing nucleosomes at the centromere 19 5.49e-01 0.079500 8.70e-01
Nucleosome assembly 19 5.49e-01 0.079500 8.70e-01
Signaling by NTRK3 (TRKC) 17 5.70e-01 0.079500 8.78e-01
NOTCH1 Intracellular Domain Regulates Transcription 41 3.79e-01 0.079400 7.82e-01
DNA Repair 225 4.17e-02 -0.078900 5.01e-01
O-linked glycosylation 93 1.89e-01 -0.078900 6.82e-01
SUMOylation of transcription cofactors 36 4.15e-01 -0.078600 7.94e-01
PPARA activates gene expression 108 1.59e-01 0.078400 6.75e-01
Nuclear Envelope (NE) Reassembly 63 2.83e-01 -0.078200 7.27e-01
HS-GAG degradation 19 5.57e-01 -0.077900 8.70e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 14 6.14e-01 -0.077900 8.99e-01
tRNA Aminoacylation 20 5.48e-01 -0.077700 8.70e-01
Signaling by NOTCH2 23 5.20e-01 0.077600 8.61e-01
G beta:gamma signalling through PI3Kgamma 19 5.59e-01 -0.077500 8.70e-01
N-glycan antennae elongation in the medial/trans-Golgi 23 5.20e-01 -0.077500 8.61e-01
EPH-ephrin mediated repulsion of cells 43 3.81e-01 -0.077300 7.82e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 53 3.31e-01 0.077100 7.52e-01
Signal Transduction 2361 1.98e-09 0.077000 5.50e-07
Synthesis of DNA 100 1.84e-01 -0.077000 6.82e-01
Digestion 20 5.53e-01 0.076600 8.70e-01
FRS-mediated FGFR1 signaling 22 5.35e-01 0.076400 8.70e-01
Deadenylation-dependent mRNA decay 45 3.77e-01 0.076200 7.82e-01
G-protein mediated events 50 3.52e-01 0.076100 7.68e-01
Signaling by NOTCH 154 1.05e-01 -0.075800 6.34e-01
G0 and Early G1 25 5.13e-01 -0.075500 8.57e-01
CYP2E1 reactions 11 6.65e-01 0.075500 9.25e-01
FRS-mediated FGFR4 signaling 20 5.59e-01 0.075400 8.70e-01
Assembly of collagen fibrils and other multimeric structures 53 3.43e-01 -0.075400 7.61e-01
SHC-mediated cascade:FGFR1 21 5.50e-01 0.075400 8.70e-01
Vitamin B5 (pantothenate) metabolism 14 6.27e-01 -0.075100 9.04e-01
mRNA Splicing - Minor Pathway 37 4.30e-01 -0.074900 8.04e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 82 2.42e-01 0.074700 7.09e-01
Toll Like Receptor 2 (TLR2) Cascade 82 2.42e-01 0.074700 7.09e-01
Toll Like Receptor TLR1:TLR2 Cascade 82 2.42e-01 0.074700 7.09e-01
Toll Like Receptor TLR6:TLR2 Cascade 82 2.42e-01 0.074700 7.09e-01
Glucagon-type ligand receptors 28 4.97e-01 -0.074200 8.49e-01
SHC-mediated cascade:FGFR4 19 5.76e-01 0.074200 8.81e-01
DAG and IP3 signaling 37 4.35e-01 0.074200 8.08e-01
Protein localization 132 1.43e-01 -0.073900 6.70e-01
Ion homeostasis 48 3.76e-01 0.073800 7.82e-01
Transcriptional activation of mitochondrial biogenesis 49 3.72e-01 -0.073700 7.82e-01
Activation of HOX genes during differentiation 45 3.94e-01 0.073500 7.84e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 45 3.94e-01 0.073500 7.84e-01
Interleukin-15 signaling 13 6.46e-01 -0.073500 9.18e-01
Intra-Golgi traffic 36 4.48e-01 0.073100 8.13e-01
Uptake and function of anthrax toxins 11 6.78e-01 -0.072300 9.31e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 25 5.32e-01 -0.072200 8.70e-01
Epigenetic regulation of gene expression 72 2.91e-01 -0.072000 7.27e-01
Nuclear Pore Complex (NPC) Disassembly 27 5.17e-01 0.072000 8.61e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 16 6.18e-01 -0.071900 9.01e-01
ZBP1(DAI) mediated induction of type I IFNs 19 5.88e-01 -0.071900 8.84e-01
MyD88 cascade initiated on plasma membrane 71 2.96e-01 0.071800 7.32e-01
Toll Like Receptor 10 (TLR10) Cascade 71 2.96e-01 0.071800 7.32e-01
Toll Like Receptor 5 (TLR5) Cascade 71 2.96e-01 0.071800 7.32e-01
MyD88-independent TLR4 cascade 85 2.53e-01 0.071700 7.11e-01
TRIF(TICAM1)-mediated TLR4 signaling 85 2.53e-01 0.071700 7.11e-01
Plasma lipoprotein assembly 15 6.31e-01 -0.071700 9.05e-01
Regulation of signaling by CBL 18 6.01e-01 0.071300 8.91e-01
CaM pathway 31 4.93e-01 0.071200 8.47e-01
Calmodulin induced events 31 4.93e-01 0.071200 8.47e-01
Export of Viral Ribonucleoproteins from Nucleus 24 5.47e-01 0.071000 8.70e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 56 3.59e-01 0.070900 7.70e-01
Keratinization 116 1.88e-01 -0.070800 6.82e-01
Purine salvage 11 6.84e-01 -0.070800 9.31e-01
Neuronal System 360 2.15e-02 0.070700 4.21e-01
Organic cation transport 10 6.99e-01 -0.070600 9.31e-01
Regulation of IFNG signaling 13 6.59e-01 -0.070600 9.24e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 6.15e-01 0.070500 8.99e-01
Platelet homeostasis 78 2.82e-01 -0.070500 7.27e-01
Fc epsilon receptor (FCERI) signaling 119 1.85e-01 0.070400 6.82e-01
Interleukin-7 signaling 17 6.17e-01 -0.070100 8.99e-01
Killing mechanisms 10 7.01e-01 -0.070000 9.31e-01
WNT5:FZD7-mediated leishmania damping 10 7.01e-01 -0.070000 9.31e-01
Fcgamma receptor (FCGR) dependent phagocytosis 89 2.55e-01 -0.069900 7.11e-01
Neutrophil degranulation 398 1.73e-02 -0.069800 4.21e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 6.89e-01 -0.069700 9.31e-01
Dectin-1 mediated noncanonical NF-kB signaling 49 4.02e-01 -0.069300 7.88e-01
Metabolism 1736 2.50e-06 -0.069000 5.79e-04
NOTCH3 Activation and Transmission of Signal to the Nucleus 19 6.05e-01 -0.068600 8.95e-01
Signaling by ROBO receptors 150 1.49e-01 0.068300 6.74e-01
Regulation of APC/C activators between G1/S and early anaphase 67 3.34e-01 -0.068300 7.55e-01
Aggrephagy 18 6.16e-01 -0.068200 8.99e-01
Interactions of Vpr with host cellular proteins 26 5.48e-01 0.068100 8.70e-01
Sphingolipid metabolism 74 3.11e-01 -0.068100 7.39e-01
Global Genome Nucleotide Excision Repair (GG-NER) 69 3.29e-01 -0.068000 7.52e-01
RNA polymerase II transcribes snRNA genes 60 3.64e-01 0.067900 7.72e-01
Cell-cell junction organization 54 3.93e-01 0.067200 7.84e-01
Norepinephrine Neurotransmitter Release Cycle 15 6.53e-01 -0.067100 9.21e-01
Mitochondrial translation termination 64 3.53e-01 -0.067100 7.68e-01
RNA Polymerase I Transcription Termination 22 5.87e-01 -0.066900 8.84e-01
Cytosolic sulfonation of small molecules 21 6.00e-01 -0.066100 8.91e-01
Synthesis of pyrophosphates in the cytosol 10 7.19e-01 -0.065800 9.35e-01
G beta:gamma signalling through PLC beta 15 6.59e-01 -0.065800 9.24e-01
Major pathway of rRNA processing in the nucleolus and cytosol 119 2.15e-01 -0.065800 6.93e-01
Interleukin-6 signaling 11 7.07e-01 -0.065400 9.31e-01
CD28 co-stimulation 32 5.25e-01 0.064900 8.66e-01
Dual incision in TC-NER 51 4.23e-01 -0.064800 7.97e-01
ER-Phagosome pathway 62 3.79e-01 -0.064700 7.82e-01
Respiratory electron transport 70 3.51e-01 0.064500 7.68e-01
Protein-protein interactions at synapses 84 3.07e-01 0.064500 7.39e-01
Transmission across Chemical Synapses 226 9.58e-02 0.064400 6.34e-01
FCGR activation 19 6.27e-01 0.064300 9.04e-01
Association of TriC/CCT with target proteins during biosynthesis 32 5.29e-01 0.064300 8.70e-01
Negative regulation of the PI3K/AKT network 105 2.56e-01 0.064200 7.11e-01
Mitochondrial translation initiation 64 3.76e-01 -0.064100 7.82e-01
Effects of PIP2 hydrolysis 25 5.80e-01 -0.064000 8.83e-01
Fatty acyl-CoA biosynthesis 29 5.53e-01 -0.063700 8.70e-01
Scavenging of heme from plasma 14 6.81e-01 0.063400 9.31e-01
Signaling by PDGFRA extracellular domain mutants 12 7.04e-01 0.063400 9.31e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.04e-01 0.063400 9.31e-01
ESR-mediated signaling 148 1.85e-01 0.063300 6.82e-01
Regulation of RUNX2 expression and activity 60 3.98e-01 0.063100 7.86e-01
Transport of small molecules 633 7.01e-03 -0.063100 3.74e-01
Iron uptake and transport 49 4.48e-01 0.062700 8.13e-01
TNFs bind their physiological receptors 26 5.80e-01 -0.062600 8.83e-01
RA biosynthesis pathway 20 6.29e-01 -0.062400 9.05e-01
Signaling by WNT in cancer 30 5.55e-01 0.062300 8.70e-01
Signaling by TGF-beta Receptor Complex 60 4.05e-01 0.062200 7.88e-01
SCF(Skp2)-mediated degradation of p27/p21 49 4.52e-01 -0.062200 8.16e-01
RHO GTPases Activate Formins 100 2.84e-01 0.062000 7.27e-01
Regulation of KIT signaling 16 6.68e-01 0.062000 9.26e-01
Arachidonic acid metabolism 50 4.52e-01 -0.061600 8.16e-01
Response to elevated platelet cytosolic Ca2+ 118 2.49e-01 -0.061500 7.11e-01
EML4 and NUDC in mitotic spindle formation 81 3.40e-01 0.061400 7.61e-01
FOXO-mediated transcription of cell cycle genes 16 6.71e-01 0.061300 9.27e-01
Pentose phosphate pathway 14 6.92e-01 -0.061100 9.31e-01
COPI-independent Golgi-to-ER retrograde traffic 32 5.51e-01 0.060900 8.70e-01
Branched-chain amino acid catabolism 19 6.50e-01 -0.060100 9.21e-01
TNFR2 non-canonical NF-kB pathway 83 3.45e-01 -0.060000 7.62e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 34 5.49e-01 0.059400 8.70e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 7.45e-01 -0.059400 9.49e-01
RNA Polymerase I Promoter Escape 22 6.30e-01 -0.059400 9.05e-01
Toll Like Receptor 3 (TLR3) Cascade 81 3.56e-01 0.059300 7.68e-01
HCMV Late Events 41 5.12e-01 -0.059200 8.57e-01
Resolution of Sister Chromatid Cohesion 89 3.37e-01 0.058900 7.61e-01
Neurotransmitter release cycle 44 5.01e-01 0.058700 8.51e-01
rRNA processing in the nucleus and cytosol 126 2.56e-01 -0.058600 7.11e-01
rRNA processing 133 2.45e-01 -0.058400 7.11e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 76 3.80e-01 0.058300 7.82e-01
Transcriptional Regulation by VENTX 35 5.52e-01 -0.058100 8.70e-01
G1/S-Specific Transcription 26 6.09e-01 -0.058000 8.96e-01
Signaling by NOTCH4 66 4.16e-01 -0.057900 7.95e-01
Host Interactions of HIV factors 102 3.13e-01 -0.057900 7.39e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 28 5.97e-01 0.057800 8.90e-01
O-glycosylation of TSR domain-containing proteins 35 5.58e-01 -0.057300 8.70e-01
Death Receptor Signalling 122 2.75e-01 -0.057300 7.27e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 19 6.67e-01 -0.057000 9.26e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 33 5.72e-01 0.056800 8.78e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 6.69e-01 -0.056600 9.26e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 6.69e-01 -0.056600 9.26e-01
Antigen processing: Ubiquitination & Proteasome degradation 262 1.16e-01 0.056600 6.34e-01
Transcriptional Regulation by TP53 307 8.97e-02 -0.056400 6.23e-01
RHO GTPases activate KTN1 10 7.59e-01 -0.056100 9.54e-01
Physiological factors 12 7.39e-01 0.055600 9.44e-01
Regulation of PTEN stability and activity 54 4.82e-01 -0.055400 8.42e-01
PI-3K cascade:FGFR1 21 6.61e-01 0.055400 9.24e-01
Formation of Incision Complex in GG-NER 33 5.83e-01 -0.055300 8.84e-01
Chylomicron remodeling 10 7.62e-01 -0.055300 9.54e-01
Transcriptional regulation by RUNX1 161 2.29e-01 -0.055000 6.98e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 34 5.79e-01 -0.055000 8.83e-01
Collagen formation 81 3.93e-01 -0.055000 7.84e-01
ABC transporters in lipid homeostasis 14 7.23e-01 -0.054700 9.36e-01
ER Quality Control Compartment (ERQC) 14 7.24e-01 -0.054600 9.36e-01
Metabolism of lipids 631 2.03e-02 -0.054400 4.21e-01
Glycogen metabolism 23 6.52e-01 -0.054300 9.21e-01
A tetrasaccharide linker sequence is required for GAG synthesis 25 6.39e-01 0.054200 9.14e-01
Transport of bile salts and organic acids, metal ions and amine compounds 75 4.18e-01 -0.054200 7.95e-01
NEP/NS2 Interacts with the Cellular Export Machinery 23 6.55e-01 0.053900 9.22e-01
PTEN Regulation 123 3.04e-01 -0.053700 7.39e-01
Centrosome maturation 70 4.38e-01 -0.053600 8.10e-01
Recruitment of mitotic centrosome proteins and complexes 70 4.38e-01 -0.053600 8.10e-01
Chondroitin sulfate/dermatan sulfate metabolism 49 5.17e-01 0.053600 8.61e-01
Chromosome Maintenance 69 4.46e-01 -0.053100 8.13e-01
Complement cascade 55 4.98e-01 -0.052900 8.49e-01
Collagen degradation 36 5.85e-01 -0.052600 8.84e-01
Nuclear signaling by ERBB4 30 6.19e-01 0.052500 9.01e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 11 7.64e-01 -0.052200 9.55e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 11 7.64e-01 -0.052200 9.55e-01
Peptide hormone biosynthesis 10 7.75e-01 0.052200 9.58e-01
Senescence-Associated Secretory Phenotype (SASP) 44 5.50e-01 -0.052200 8.70e-01
Glycogen breakdown (glycogenolysis) 14 7.36e-01 -0.052100 9.41e-01
PI-3K cascade:FGFR4 19 6.94e-01 0.052100 9.31e-01
Opioid Signalling 79 4.24e-01 0.052100 7.97e-01
Phase 0 - rapid depolarisation 39 5.75e-01 -0.051900 8.81e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 73 4.46e-01 -0.051600 8.13e-01
Post-translational protein phosphorylation 98 3.77e-01 0.051600 7.82e-01
MET activates PTK2 signaling 18 7.06e-01 -0.051400 9.31e-01
Signaling by KIT in disease 20 6.92e-01 0.051300 9.31e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.92e-01 0.051300 9.31e-01
Transcriptional regulation of pluripotent stem cells 28 6.40e-01 -0.051100 9.14e-01
Cell-Cell communication 109 3.57e-01 0.051100 7.68e-01
Eukaryotic Translation Termination 48 5.42e-01 0.051000 8.70e-01
Rab regulation of trafficking 108 3.62e-01 -0.050800 7.70e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 31 6.26e-01 0.050600 9.04e-01
Transport of Mature Transcript to Cytoplasm 63 4.88e-01 0.050500 8.43e-01
Vpr-mediated nuclear import of PICs 24 6.69e-01 0.050500 9.26e-01
Signaling by Rho GTPases 342 1.11e-01 -0.050300 6.34e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 6.78e-01 0.050100 9.31e-01
Potassium Channels 94 4.03e-01 0.049900 7.88e-01
RHO GTPases activate PAKs 21 6.92e-01 -0.049900 9.31e-01
MET promotes cell motility 29 6.45e-01 0.049400 9.17e-01
VEGFA-VEGFR2 Pathway 92 4.18e-01 -0.048900 7.95e-01
Cargo recognition for clathrin-mediated endocytosis 89 4.26e-01 0.048800 8.00e-01
Ion channel transport 156 2.95e-01 0.048600 7.32e-01
Complex I biogenesis 39 6.00e-01 0.048500 8.91e-01
NIK-->noncanonical NF-kB signaling 46 5.71e-01 -0.048300 8.78e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 50 5.55e-01 -0.048200 8.70e-01
Class I MHC mediated antigen processing & presentation 310 1.46e-01 0.048100 6.70e-01
Chaperone Mediated Autophagy 18 7.24e-01 -0.048000 9.36e-01
Class B/2 (Secretin family receptors) 82 4.56e-01 0.047600 8.20e-01
Nonhomologous End-Joining (NHEJ) 28 6.64e-01 -0.047400 9.25e-01
Acetylcholine binding and downstream events 14 7.59e-01 -0.047400 9.54e-01
Postsynaptic nicotinic acetylcholine receptors 14 7.59e-01 -0.047400 9.54e-01
Interleukin-10 signaling 40 6.05e-01 0.047300 8.95e-01
EPH-Ephrin signaling 84 4.54e-01 -0.047300 8.18e-01
Signaling by VEGF 98 4.20e-01 -0.047200 7.95e-01
Influenza Infection 92 4.35e-01 0.047100 8.08e-01
Regulation of PLK1 Activity at G2/M Transition 73 4.87e-01 0.047000 8.43e-01
Ub-specific processing proteases 156 3.11e-01 0.047000 7.39e-01
Abacavir transport and metabolism 10 7.97e-01 -0.046900 9.68e-01
Nicotinate metabolism 25 6.85e-01 -0.046800 9.31e-01
Recruitment of NuMA to mitotic centrosomes 69 5.03e-01 -0.046600 8.52e-01
Translation 186 2.74e-01 -0.046500 7.27e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 23 6.99e-01 -0.046500 9.31e-01
RNA Polymerase III Transcription Initiation 28 6.71e-01 -0.046300 9.27e-01
E2F mediated regulation of DNA replication 19 7.27e-01 0.046200 9.36e-01
Heme biosynthesis 12 7.82e-01 -0.046200 9.63e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 7.35e-01 -0.046100 9.41e-01
SUMOylation of DNA replication proteins 34 6.42e-01 -0.046100 9.15e-01
Scavenging by Class A Receptors 17 7.42e-01 0.046000 9.47e-01
mRNA decay by 3' to 5' exoribonuclease 12 7.83e-01 -0.046000 9.63e-01
TRP channels 24 6.97e-01 0.045900 9.31e-01
C-type lectin receptors (CLRs) 116 3.94e-01 0.045800 7.84e-01
GPCR ligand binding 403 1.17e-01 0.045600 6.34e-01
Processing of Capped Intron-Containing Pre-mRNA 182 2.89e-01 0.045600 7.27e-01
Serotonin Neurotransmitter Release Cycle 14 7.68e-01 0.045500 9.56e-01
Transcription of the HIV genome 54 5.63e-01 -0.045500 8.72e-01
Switching of origins to a post-replicative state 75 4.98e-01 -0.045300 8.49e-01
DNA Damage Recognition in GG-NER 28 6.79e-01 -0.045300 9.31e-01
Activation of the pre-replicative complex 27 6.84e-01 -0.045200 9.31e-01
Diseases associated with glycosaminoglycan metabolism 39 6.26e-01 0.045100 9.04e-01
Synthesis of very long-chain fatty acyl-CoAs 20 7.28e-01 0.044800 9.36e-01
GP1b-IX-V activation signalling 10 8.07e-01 0.044700 9.74e-01
Antiviral mechanism by IFN-stimulated genes 59 5.54e-01 -0.044600 8.70e-01
Activation of G protein gated Potassium channels 24 7.07e-01 -0.044300 9.31e-01
G protein gated Potassium channels 24 7.07e-01 -0.044300 9.31e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 24 7.07e-01 -0.044300 9.31e-01
Early Phase of HIV Life Cycle 10 8.09e-01 -0.044200 9.74e-01
Triglyceride catabolism 21 7.26e-01 0.044100 9.36e-01
COPI-mediated anterograde transport 74 5.12e-01 -0.044100 8.57e-01
Glucagon signaling in metabolic regulation 28 6.87e-01 0.044100 9.31e-01
RNA Polymerase III Transcription Termination 18 7.47e-01 -0.044000 9.49e-01
Glutamate Neurotransmitter Release Cycle 22 7.22e-01 -0.043900 9.35e-01
WNT ligand biogenesis and trafficking 24 7.10e-01 0.043800 9.33e-01
Transferrin endocytosis and recycling 28 6.89e-01 0.043800 9.31e-01
Digestion and absorption 25 7.05e-01 -0.043700 9.31e-01
Signaling by Insulin receptor 72 5.22e-01 0.043700 8.62e-01
G2/M Checkpoints 109 4.32e-01 -0.043600 8.06e-01
Formation of RNA Pol II elongation complex 42 6.27e-01 -0.043400 9.04e-01
RNA Polymerase II Transcription Elongation 42 6.27e-01 -0.043400 9.04e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 30 6.82e-01 -0.043200 9.31e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 77 5.13e-01 0.043100 8.57e-01
Amplification of signal from the kinetochores 77 5.13e-01 0.043100 8.57e-01
FGFR4 ligand binding and activation 13 7.88e-01 -0.043000 9.65e-01
Prolactin receptor signaling 15 7.73e-01 0.043000 9.58e-01
Vasopressin regulates renal water homeostasis via Aquaporins 37 6.52e-01 -0.042800 9.21e-01
Hedgehog 'on' state 71 5.34e-01 -0.042700 8.70e-01
GABA synthesis, release, reuptake and degradation 17 7.61e-01 0.042600 9.54e-01
Amine ligand-binding receptors 39 6.46e-01 0.042600 9.17e-01
Degradation of GLI2 by the proteasome 47 6.15e-01 -0.042400 8.99e-01
Ethanol oxidation 11 8.08e-01 0.042300 9.74e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 8.11e-01 -0.041700 9.74e-01
VxPx cargo-targeting to cilium 20 7.51e-01 0.041100 9.51e-01
PI3K Cascade 41 6.50e-01 -0.040900 9.21e-01
Potential therapeutics for SARS 33 6.85e-01 0.040900 9.31e-01
Methylation 11 8.15e-01 0.040800 9.75e-01
Tie2 Signaling 17 7.71e-01 0.040800 9.57e-01
Platelet activation, signaling and aggregation 233 2.86e-01 -0.040700 7.27e-01
Interactions of Rev with host cellular proteins 26 7.20e-01 0.040600 9.35e-01
Regulation of expression of SLITs and ROBOs 110 4.63e-01 0.040500 8.25e-01
HATs acetylate histones 65 5.72e-01 -0.040500 8.78e-01
Late endosomal microautophagy 26 7.21e-01 -0.040400 9.35e-01
Retrograde neurotrophin signalling 14 7.94e-01 -0.040400 9.65e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 111 4.67e-01 0.040000 8.28e-01
Deubiquitination 222 3.11e-01 0.039500 7.39e-01
Organelle biogenesis and maintenance 229 3.05e-01 -0.039400 7.39e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 15 7.93e-01 0.039200 9.65e-01
NCAM signaling for neurite out-growth 55 6.15e-01 -0.039200 8.99e-01
AURKA Activation by TPX2 62 5.94e-01 -0.039200 8.89e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 6.64e-01 -0.039200 9.25e-01
Triglyceride metabolism 33 6.97e-01 0.039100 9.31e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 60 6.00e-01 0.039100 8.91e-01
DARPP-32 events 21 7.57e-01 0.039100 9.54e-01
Platelet degranulation 114 4.72e-01 -0.039000 8.32e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 8.23e-01 -0.039000 9.75e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 62 5.96e-01 -0.038900 8.90e-01
Semaphorin interactions 60 6.09e-01 -0.038200 8.96e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 10 8.35e-01 0.038100 9.80e-01
Activation of BH3-only proteins 28 7.28e-01 0.037900 9.36e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 8.36e-01 -0.037800 9.80e-01
Muscle contraction 188 3.73e-01 -0.037800 7.82e-01
Apoptosis 146 4.33e-01 0.037600 8.06e-01
Nucleotide Excision Repair 87 5.45e-01 -0.037600 8.70e-01
Regulation of actin dynamics for phagocytic cup formation 66 5.99e-01 -0.037500 8.91e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 45 6.64e-01 0.037500 9.25e-01
ADORA2B mediated anti-inflammatory cytokines production 121 4.77e-01 0.037500 8.37e-01
APC-Cdc20 mediated degradation of Nek2A 21 7.66e-01 -0.037500 9.56e-01
HCMV Early Events 47 6.57e-01 0.037400 9.24e-01
Presynaptic phase of homologous DNA pairing and strand exchange 33 7.11e-01 -0.037300 9.33e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 7.15e-01 -0.036700 9.35e-01
Diseases of mitotic cell cycle 33 7.15e-01 -0.036700 9.35e-01
Constitutive Signaling by Aberrant PI3K in Cancer 73 5.88e-01 0.036700 8.84e-01
Degradation of beta-catenin by the destruction complex 71 5.93e-01 -0.036700 8.89e-01
Orc1 removal from chromatin 57 6.37e-01 -0.036100 9.14e-01
Disease 1235 3.49e-02 -0.036100 4.69e-01
B-WICH complex positively regulates rRNA expression 24 7.61e-01 -0.035900 9.54e-01
Post-translational modification: synthesis of GPI-anchored proteins 75 5.92e-01 -0.035800 8.88e-01
HIV Infection 179 4.10e-01 -0.035800 7.92e-01
Detoxification of Reactive Oxygen Species 29 7.40e-01 0.035600 9.45e-01
Activation of GABAB receptors 38 7.06e-01 0.035400 9.31e-01
GABA B receptor activation 38 7.06e-01 0.035400 9.31e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 99 5.44e-01 0.035300 8.70e-01
Acetylcholine Neurotransmitter Release Cycle 14 8.19e-01 0.035300 9.75e-01
Degradation of GLI1 by the proteasome 48 6.74e-01 -0.035100 9.28e-01
FGFR2 mutant receptor activation 26 7.57e-01 0.035100 9.54e-01
Synthesis of PC 25 7.62e-01 -0.035000 9.54e-01
Mitotic Anaphase 194 4.01e-01 -0.035000 7.88e-01
Regulation of Complement cascade 45 6.86e-01 -0.034800 9.31e-01
Programmed Cell Death 149 4.64e-01 0.034800 8.25e-01
IRS-related events triggered by IGF1R 49 6.77e-01 0.034400 9.31e-01
SARS-CoV-1 Infection 38 7.14e-01 -0.034400 9.35e-01
Insulin receptor signalling cascade 51 6.71e-01 0.034400 9.27e-01
Signaling by the B Cell Receptor (BCR) 100 5.54e-01 0.034300 8.70e-01
Viral mRNA Translation 45 6.91e-01 0.034300 9.31e-01
Diseases associated with the TLR signaling cascade 20 7.91e-01 -0.034300 9.65e-01
Diseases of Immune System 20 7.91e-01 -0.034300 9.65e-01
Signaling by RAF1 mutants 38 7.17e-01 0.033900 9.35e-01
G beta:gamma signalling through BTK 13 8.33e-01 -0.033800 9.79e-01
PKA activation in glucagon signalling 16 8.16e-01 0.033700 9.75e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 19 8.02e-01 0.033200 9.71e-01
Mitotic Metaphase and Anaphase 195 4.27e-01 -0.033100 8.00e-01
Formation of TC-NER Pre-Incision Complex 39 7.21e-01 0.033000 9.35e-01
Condensation of Prophase Chromosomes 10 8.57e-01 -0.032900 9.81e-01
IGF1R signaling cascade 50 6.90e-01 0.032700 9.31e-01
Cell-extracellular matrix interactions 14 8.33e-01 -0.032600 9.79e-01
Regulation of insulin secretion 70 6.39e-01 -0.032400 9.14e-01
Toll-like Receptor Cascades 131 5.31e-01 0.031700 8.70e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 6.99e-01 0.031600 9.31e-01
Cargo trafficking to the periciliary membrane 43 7.20e-01 0.031600 9.35e-01
mRNA Splicing - Major Pathway 134 5.30e-01 0.031500 8.70e-01
Rev-mediated nuclear export of HIV RNA 25 7.86e-01 0.031500 9.65e-01
FCERI mediated NF-kB activation 69 6.52e-01 0.031400 9.21e-01
Signaling by SCF-KIT 43 7.24e-01 -0.031100 9.36e-01
L13a-mediated translational silencing of Ceruloplasmin expression 58 6.83e-01 0.031000 9.31e-01
Amino acids regulate mTORC1 47 7.18e-01 0.030500 9.35e-01
Lysine catabolism 12 8.56e-01 -0.030300 9.81e-01
Triglyceride biosynthesis 12 8.56e-01 0.030300 9.81e-01
VEGFR2 mediated vascular permeability 27 7.86e-01 0.030200 9.65e-01
Golgi Associated Vesicle Biogenesis 48 7.17e-01 0.030200 9.35e-01
Downstream signaling events of B Cell Receptor (BCR) 68 6.69e-01 0.030000 9.26e-01
Cyclin A:Cdk2-associated events at S phase entry 72 6.61e-01 -0.029900 9.24e-01
Phase 4 - resting membrane potential 18 8.27e-01 -0.029800 9.77e-01
Signalling to RAS 20 8.19e-01 -0.029600 9.75e-01
trans-Golgi Network Vesicle Budding 61 6.92e-01 -0.029400 9.31e-01
SUMOylation of DNA damage response and repair proteins 56 7.04e-01 -0.029300 9.31e-01
Eicosanoid ligand-binding receptors 13 8.55e-01 0.029300 9.81e-01
Signaling by FGFR in disease 55 7.09e-01 0.029100 9.33e-01
Protein folding 86 6.41e-01 -0.029100 9.15e-01
Signaling by NOTCH3 41 7.51e-01 -0.028700 9.51e-01
G-protein activation 23 8.13e-01 0.028500 9.75e-01
G alpha (i) signalling events 351 3.61e-01 0.028500 7.70e-01
Signaling by Nuclear Receptors 216 4.71e-01 -0.028500 8.32e-01
COPII-mediated vesicle transport 57 7.11e-01 -0.028400 9.33e-01
mRNA Splicing 142 5.60e-01 0.028400 8.70e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 51 7.27e-01 0.028300 9.36e-01
The citric acid (TCA) cycle and respiratory electron transport 118 5.97e-01 0.028200 8.91e-01
RNA Polymerase II Transcription 970 1.43e-01 0.028000 6.70e-01
ERK/MAPK targets 22 8.21e-01 0.027900 9.75e-01
Lewis blood group biosynthesis 12 8.68e-01 -0.027700 9.81e-01
Budding and maturation of HIV virion 20 8.31e-01 -0.027500 9.79e-01
ER to Golgi Anterograde Transport 117 6.09e-01 -0.027400 8.96e-01
Sema3A PAK dependent Axon repulsion 15 8.54e-01 -0.027400 9.81e-01
eNOS activation 10 8.81e-01 -0.027300 9.81e-01
Aspartate and asparagine metabolism 11 8.76e-01 -0.027200 9.81e-01
G-protein beta:gamma signalling 26 8.11e-01 -0.027100 9.74e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.45e-01 0.026600 9.81e-01
Peptide ligand-binding receptors 172 5.47e-01 0.026600 8.70e-01
G1/S Transition 110 6.30e-01 -0.026600 9.05e-01
Generation of second messenger molecules 26 8.15e-01 -0.026500 9.75e-01
RORA activates gene expression 17 8.51e-01 -0.026300 9.81e-01
Ion transport by P-type ATPases 48 7.53e-01 -0.026300 9.53e-01
SUMOylation 142 5.91e-01 -0.026200 8.87e-01
FGFR1 ligand binding and activation 15 8.63e-01 -0.025800 9.81e-01
Regulation of localization of FOXO transcription factors 12 8.78e-01 0.025700 9.81e-01
Transport of the SLBP Dependant Mature mRNA 25 8.25e-01 0.025600 9.76e-01
Peptide chain elongation 45 7.71e-01 0.025100 9.57e-01
Hemostasis 537 3.23e-01 -0.025000 7.47e-01
NF-kB is activated and signals survival 10 8.92e-01 0.024900 9.81e-01
S Phase 139 6.15e-01 -0.024700 8.99e-01
Mitotic Spindle Checkpoint 92 6.85e-01 0.024500 9.31e-01
M Phase 295 4.73e-01 -0.024300 8.34e-01
Intrinsic Pathway for Apoptosis 44 7.80e-01 -0.024300 9.62e-01
Mitotic G1 phase and G1/S transition 126 6.38e-01 -0.024300 9.14e-01
G alpha (q) signalling events 195 5.60e-01 0.024200 8.70e-01
Cellular Senescence 115 6.55e-01 -0.024200 9.22e-01
Loss of Nlp from mitotic centrosomes 60 7.47e-01 -0.024100 9.49e-01
Loss of proteins required for interphase microtubule organization from the centrosome 60 7.47e-01 -0.024100 9.49e-01
Interleukin-1 family signaling 117 6.59e-01 0.023700 9.24e-01
RNA Pol II CTD phosphorylation and interaction with CE 20 8.55e-01 -0.023600 9.81e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 20 8.55e-01 -0.023600 9.81e-01
Interleukin-12 family signaling 48 7.78e-01 0.023500 9.60e-01
Signaling by PDGF 52 7.71e-01 -0.023400 9.57e-01
Collagen biosynthesis and modifying enzymes 61 7.54e-01 -0.023300 9.53e-01
G2/M Transition 153 6.20e-01 -0.023200 9.01e-01
GLI3 is processed to GLI3R by the proteasome 47 7.83e-01 -0.023200 9.63e-01
RHO GTPases activate PKNs 31 8.24e-01 0.023100 9.75e-01
Vesicle-mediated transport 573 3.46e-01 -0.023100 7.63e-01
Synthesis of glycosylphosphatidylinositol (GPI) 14 8.81e-01 -0.023100 9.81e-01
Transcriptional regulation of white adipocyte differentiation 75 7.29e-01 0.023100 9.36e-01
SUMOylation of intracellular receptors 28 8.33e-01 -0.023100 9.79e-01
Signaling by Receptor Tyrosine Kinases 457 4.04e-01 0.022900 7.88e-01
Adaptive Immune System 609 3.42e-01 0.022700 7.61e-01
RNA Polymerase III Abortive And Retractive Initiation 33 8.22e-01 -0.022600 9.75e-01
RNA Polymerase III Transcription 33 8.22e-01 -0.022600 9.75e-01
Transcriptional regulation by small RNAs 33 8.23e-01 -0.022500 9.75e-01
Initiation of Nuclear Envelope (NE) Reformation 18 8.70e-01 -0.022300 9.81e-01
Activation of NF-kappaB in B cells 56 7.73e-01 -0.022300 9.58e-01
Cell Cycle 525 3.84e-01 -0.022300 7.82e-01
Innate Immune System 863 2.76e-01 -0.022000 7.27e-01
Late Phase of HIV Life Cycle 101 7.03e-01 -0.022000 9.31e-01
RHO GTPase Effectors 220 5.80e-01 -0.021700 8.83e-01
Metabolism of cofactors 19 8.70e-01 -0.021700 9.81e-01
Collagen chain trimerization 42 8.11e-01 -0.021400 9.74e-01
Postmitotic nuclear pore complex (NPC) reformation 20 8.69e-01 -0.021300 9.81e-01
Ephrin signaling 19 8.73e-01 0.021200 9.81e-01
Dectin-2 family 21 8.68e-01 0.021000 9.81e-01
Recycling pathway of L1 27 8.51e-01 0.020900 9.81e-01
Inflammasomes 18 8.79e-01 -0.020700 9.81e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 8.97e-01 0.020700 9.81e-01
Mitotic G2-G2/M phases 155 6.58e-01 -0.020600 9.24e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 23 8.65e-01 -0.020500 9.81e-01
Signaling by NTRKs 131 6.87e-01 0.020400 9.31e-01
Anchoring of the basal body to the plasma membrane 82 7.51e-01 -0.020300 9.51e-01
Metabolism of proteins 1584 1.85e-01 -0.020200 6.82e-01
Interaction between L1 and Ankyrins 28 8.54e-01 -0.020100 9.81e-01
Synthesis of PIPs at the plasma membrane 52 8.02e-01 0.020100 9.71e-01
Sphingolipid de novo biosynthesis 38 8.30e-01 0.020100 9.79e-01
Transport of the SLBP independent Mature mRNA 24 8.66e-01 0.019900 9.81e-01
Eukaryotic Translation Elongation 48 8.15e-01 0.019500 9.75e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 8.93e-01 0.019400 9.81e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 8.93e-01 0.019400 9.81e-01
Purine catabolism 17 8.91e-01 0.019200 9.81e-01
Cilium Assembly 162 6.74e-01 -0.019200 9.28e-01
Calnexin/calreticulin cycle 17 8.91e-01 -0.019200 9.81e-01
Biosynthesis of DHA-derived SPMs 16 8.95e-01 0.019100 9.81e-01
Leishmania infection 236 6.15e-01 -0.019100 8.99e-01
Cell Cycle, Mitotic 419 5.05e-01 -0.019000 8.54e-01
Endogenous sterols 25 8.71e-01 0.018700 9.81e-01
MTOR signalling 35 8.48e-01 -0.018700 9.81e-01
Axon guidance 445 5.03e-01 0.018600 8.52e-01
HIV Life Cycle 110 7.37e-01 -0.018500 9.42e-01
Amyloid fiber formation 43 8.34e-01 0.018400 9.80e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 50 8.22e-01 -0.018400 9.75e-01
Processing of DNA double-strand break ends 52 8.19e-01 -0.018400 9.75e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 14 9.05e-01 -0.018400 9.84e-01
Membrane Trafficking 535 4.77e-01 -0.018100 8.37e-01
Nervous system development 468 5.06e-01 0.018000 8.54e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 35 8.54e-01 0.018000 9.81e-01
Formation of Fibrin Clot (Clotting Cascade) 36 8.54e-01 0.017800 9.81e-01
RNA Polymerase II Pre-transcription Events 63 8.09e-01 -0.017600 9.74e-01
Mitotic Prophase 66 8.05e-01 0.017600 9.73e-01
Oxidative Stress Induced Senescence 58 8.18e-01 -0.017500 9.75e-01
Cell junction organization 76 7.93e-01 -0.017400 9.65e-01
Influenza Viral RNA Transcription and Replication 77 7.94e-01 0.017200 9.65e-01
RHO GTPases Activate WASPs and WAVEs 35 8.60e-01 0.017200 9.81e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 22 8.89e-01 0.017200 9.81e-01
Metabolism of porphyrins 25 8.84e-01 -0.016800 9.81e-01
Downstream signal transduction 29 8.76e-01 0.016800 9.81e-01
Transport to the Golgi and subsequent modification 144 7.29e-01 -0.016800 9.36e-01
CTLA4 inhibitory signaling 21 8.95e-01 -0.016600 9.81e-01
Mitotic Prometaphase 158 7.19e-01 0.016600 9.35e-01
Signaling by NTRK1 (TRKA) 113 7.61e-01 0.016600 9.54e-01
Toll Like Receptor 4 (TLR4) Cascade 110 7.68e-01 0.016300 9.56e-01
Costimulation by the CD28 family 60 8.29e-01 -0.016100 9.79e-01
RAF-independent MAPK1/3 activation 23 8.94e-01 -0.016000 9.81e-01
Immune System 1753 2.75e-01 -0.015900 7.27e-01
FGFR1 mutant receptor activation 30 8.81e-01 0.015800 9.81e-01
Transport of Mature mRNA Derived from an Intronless Transcript 30 8.81e-01 -0.015800 9.81e-01
NoRC negatively regulates rRNA expression 34 8.74e-01 -0.015700 9.81e-01
Signaling by Erythropoietin 24 8.95e-01 0.015500 9.81e-01
Presynaptic function of Kainate receptors 16 9.15e-01 -0.015500 9.85e-01
Classical antibody-mediated complement activation 13 9.24e-01 0.015300 9.89e-01
Clathrin-mediated endocytosis 126 7.67e-01 0.015300 9.56e-01
Intraflagellar transport 38 8.73e-01 -0.015000 9.81e-01
Gene expression (Transcription) 1079 4.14e-01 0.014900 7.94e-01
Nicotinamide salvaging 15 9.21e-01 -0.014800 9.89e-01
Deactivation of the beta-catenin transactivating complex 34 8.82e-01 -0.014700 9.81e-01
RHO GTPases Activate ROCKs 18 9.14e-01 -0.014700 9.85e-01
Post-translational protein modification 1148 4.11e-01 -0.014500 7.92e-01
SUMO E3 ligases SUMOylate target proteins 136 7.71e-01 -0.014500 9.57e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 8.92e-01 -0.014400 9.81e-01
Activation of Matrix Metalloproteinases 29 8.94e-01 -0.014400 9.81e-01
PI3K/AKT Signaling in Cancer 98 8.06e-01 0.014300 9.74e-01
TNFR1-induced NFkappaB signaling pathway 24 9.05e-01 -0.014100 9.84e-01
ECM proteoglycans 54 8.58e-01 -0.014100 9.81e-01
tRNA processing in the nucleus 47 8.67e-01 0.014100 9.81e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 162 7.57e-01 0.014100 9.54e-01
NGF-stimulated transcription 39 8.79e-01 -0.014100 9.81e-01
mRNA Capping 21 9.11e-01 -0.014100 9.84e-01
Generic Transcription Pathway 872 4.87e-01 0.014000 8.43e-01
CRMPs in Sema3A signaling 15 9.26e-01 -0.013800 9.89e-01
L1CAM interactions 95 8.16e-01 0.013800 9.75e-01
Cellular response to hypoxia 59 8.54e-01 -0.013800 9.81e-01
CD28 dependent PI3K/Akt signaling 21 9.14e-01 0.013700 9.85e-01
Cell Cycle Checkpoints 213 7.34e-01 -0.013500 9.41e-01
Activation of kainate receptors upon glutamate binding 25 9.08e-01 0.013300 9.84e-01
Polo-like kinase mediated events 13 9.34e-01 -0.013300 9.90e-01
Nucleobase catabolism 33 8.95e-01 0.013200 9.81e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 8.84e-01 -0.013200 9.81e-01
Signaling by RAS mutants 41 8.84e-01 -0.013200 9.81e-01
Signaling by moderate kinase activity BRAF mutants 41 8.84e-01 -0.013200 9.81e-01
Signaling downstream of RAS mutants 41 8.84e-01 -0.013200 9.81e-01
MAPK family signaling cascades 287 7.02e-01 -0.013200 9.31e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 9.37e-01 -0.013100 9.91e-01
Mitochondrial Fatty Acid Beta-Oxidation 30 9.02e-01 -0.012900 9.82e-01
Formation of a pool of free 40S subunits 54 8.70e-01 0.012900 9.81e-01
Nitric oxide stimulates guanylate cyclase 22 9.17e-01 0.012900 9.85e-01
ISG15 antiviral mechanism 53 8.72e-01 0.012800 9.81e-01
Common Pathway of Fibrin Clot Formation 20 9.21e-01 0.012800 9.89e-01
Trafficking and processing of endosomal TLR 11 9.42e-01 -0.012600 9.91e-01
Separation of Sister Chromatids 141 7.97e-01 -0.012600 9.68e-01
MAP2K and MAPK activation 35 8.97e-01 0.012600 9.81e-01
Metabolic disorders of biological oxidation enzymes 33 9.01e-01 -0.012500 9.82e-01
Nuclear import of Rev protein 24 9.16e-01 0.012500 9.85e-01
p75NTR signals via NF-kB 11 9.43e-01 -0.012400 9.91e-01
HCMV Infection 65 8.64e-01 -0.012300 9.81e-01
Rap1 signalling 15 9.34e-01 -0.012300 9.90e-01
DNA Damage/Telomere Stress Induced Senescence 25 9.16e-01 -0.012200 9.85e-01
Anti-inflammatory response favouring Leishmania parasite infection 160 7.94e-01 0.012000 9.65e-01
Leishmania parasite growth and survival 160 7.94e-01 0.012000 9.65e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 48 8.86e-01 -0.012000 9.81e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 48 8.86e-01 -0.012000 9.81e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 48 8.86e-01 -0.012000 9.81e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 48 8.86e-01 -0.012000 9.81e-01
Signaling by NOTCH1 in Cancer 48 8.86e-01 -0.012000 9.81e-01
NRIF signals cell death from the nucleus 11 9.46e-01 -0.011900 9.91e-01
Infectious disease 601 6.23e-01 -0.011800 9.04e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 10 9.49e-01 -0.011700 9.92e-01
Signaling by MET 63 8.73e-01 0.011600 9.81e-01
Cellular responses to stress 393 6.95e-01 0.011600 9.31e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 9.25e-01 0.011400 9.89e-01
Glycosaminoglycan metabolism 109 8.38e-01 0.011300 9.81e-01
Biosynthesis of specialized proresolving mediators (SPMs) 18 9.34e-01 -0.011300 9.90e-01
Signaling by PDGFR in disease 19 9.33e-01 0.011100 9.90e-01
SARS-CoV Infections 70 8.73e-01 -0.011000 9.81e-01
G2/M DNA damage checkpoint 51 8.92e-01 -0.011000 9.81e-01
Signal transduction by L1 19 9.35e-01 0.010900 9.90e-01
Signaling by WNT 237 7.75e-01 -0.010800 9.58e-01
Cap-dependent Translation Initiation 66 8.80e-01 -0.010700 9.81e-01
Eukaryotic Translation Initiation 66 8.80e-01 -0.010700 9.81e-01
SUMOylation of RNA binding proteins 36 9.11e-01 -0.010700 9.84e-01
MAPK1/MAPK3 signaling 251 7.76e-01 -0.010500 9.58e-01
Translation of structural proteins 22 9.33e-01 -0.010400 9.90e-01
Nuclear Envelope Breakdown 41 9.09e-01 0.010300 9.84e-01
Hedgehog 'off' state 86 8.71e-01 -0.010100 9.81e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 31 9.23e-01 -0.010000 9.89e-01
Downstream TCR signaling 76 8.80e-01 -0.010000 9.81e-01
Regulation of RAS by GAPs 56 8.99e-01 -0.009840 9.82e-01
Selenoamino acid metabolism 62 8.94e-01 -0.009810 9.81e-01
Antimicrobial peptides 55 9.00e-01 -0.009780 9.82e-01
Nuclear Receptor transcription pathway 52 9.08e-01 -0.009270 9.84e-01
Ca2+ pathway 55 9.07e-01 -0.009120 9.84e-01
PI Metabolism 79 8.89e-01 -0.009110 9.81e-01
Cellular response to heat stress 74 8.94e-01 0.008950 9.81e-01
Attenuation phase 19 9.47e-01 0.008850 9.92e-01
Creation of C4 and C2 activators 20 9.46e-01 0.008830 9.91e-01
Negative regulation of MAPK pathway 39 9.24e-01 -0.008780 9.89e-01
Smooth Muscle Contraction 35 9.30e-01 -0.008570 9.90e-01
Interleukin-1 signaling 82 8.95e-01 0.008450 9.81e-01
Diseases of signal transduction by growth factor receptors and second messengers 337 7.91e-01 -0.008430 9.65e-01
TCR signaling 97 8.92e-01 0.008000 9.81e-01
N-Glycan antennae elongation 14 9.59e-01 -0.007980 9.93e-01
SUMOylation of ubiquitinylation proteins 28 9.43e-01 -0.007880 9.91e-01
Transcriptional Regulation by E2F6 30 9.41e-01 -0.007840 9.91e-01
Neurexins and neuroligins 54 9.22e-01 0.007680 9.89e-01
Interconversion of nucleotide di- and triphosphates 25 9.48e-01 -0.007610 9.92e-01
Signaling by Interleukins 394 8.02e-01 -0.007370 9.71e-01
Activation of ATR in response to replication stress 29 9.46e-01 -0.007310 9.91e-01
TNF signaling 34 9.43e-01 0.007130 9.91e-01
Signaling by Hedgehog 118 8.95e-01 -0.007040 9.81e-01
RAF/MAP kinase cascade 245 8.55e-01 -0.006780 9.81e-01
Phospholipase C-mediated cascade; FGFR4 14 9.66e-01 -0.006660 9.93e-01
Viral Messenger RNA Synthesis 29 9.52e-01 -0.006390 9.93e-01
FGFR1c ligand binding and activation 11 9.71e-01 -0.006340 9.93e-01
Signaling by activated point mutants of FGFR1 11 9.71e-01 -0.006340 9.93e-01
TCF dependent signaling in response to WNT 152 8.93e-01 -0.006330 9.81e-01
Selenocysteine synthesis 48 9.41e-01 0.006230 9.91e-01
MAPK3 (ERK1) activation 10 9.73e-01 -0.006190 9.93e-01
Signaling by NOTCH1 63 9.35e-01 0.005980 9.90e-01
cGMP effects 16 9.67e-01 -0.005950 9.93e-01
Beta defensins 22 9.62e-01 -0.005890 9.93e-01
Signal amplification 27 9.58e-01 0.005840 9.93e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23 9.62e-01 0.005780 9.93e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 23 9.62e-01 0.005780 9.93e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 78 9.31e-01 -0.005700 9.90e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 9.73e-01 -0.005500 9.93e-01
Defective EXT2 causes exostoses 2 13 9.73e-01 -0.005500 9.93e-01
Developmental Biology 820 7.92e-01 0.005460 9.65e-01
TP53 Regulates Metabolic Genes 74 9.37e-01 -0.005330 9.91e-01
SUMOylation of chromatin organization proteins 44 9.52e-01 0.005260 9.93e-01
Estrogen-dependent gene expression 83 9.35e-01 0.005200 9.90e-01
SUMOylation of SUMOylation proteins 23 9.66e-01 -0.005190 9.93e-01
PIP3 activates AKT signaling 241 8.90e-01 -0.005160 9.81e-01
Neddylation 193 9.02e-01 0.005120 9.82e-01
Defensins 24 9.66e-01 0.005080 9.93e-01
Cyclin E associated events during G1/S transition 70 9.42e-01 -0.005010 9.91e-01
Phospholipase C-mediated cascade: FGFR1 16 9.73e-01 0.004940 9.93e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 11 9.78e-01 0.004870 9.93e-01
Oncogenic MAPK signaling 73 9.44e-01 0.004790 9.91e-01
FOXO-mediated transcription of cell death genes 14 9.76e-01 -0.004580 9.93e-01
Regulation of RUNX1 Expression and Activity 16 9.75e-01 0.004490 9.93e-01
FLT3 Signaling 259 9.02e-01 -0.004440 9.82e-01
HIV Transcription Initiation 38 9.62e-01 -0.004430 9.93e-01
RNA Polymerase II HIV Promoter Escape 38 9.62e-01 -0.004430 9.93e-01
RNA Polymerase II Promoter Escape 38 9.62e-01 -0.004430 9.93e-01
RNA Polymerase II Transcription Initiation 38 9.62e-01 -0.004430 9.93e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 38 9.62e-01 -0.004430 9.93e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 38 9.62e-01 -0.004430 9.93e-01
Cardiac conduction 126 9.35e-01 -0.004230 9.90e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 26 9.71e-01 -0.004180 9.93e-01
Interleukin-35 Signalling 12 9.81e-01 0.004020 9.93e-01
CLEC7A (Dectin-1) signaling 83 9.52e-01 0.003830 9.93e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 14 9.81e-01 0.003630 9.93e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 44 9.67e-01 0.003580 9.93e-01
Defects in vitamin and cofactor metabolism 15 9.82e-01 -0.003450 9.93e-01
Chaperonin-mediated protein folding 80 9.58e-01 -0.003400 9.93e-01
Cytokine Signaling in Immune system 742 8.77e-01 0.003360 9.81e-01
Platelet calcium homeostasis 26 9.77e-01 -0.003300 9.93e-01
RAF activation 31 9.75e-01 0.003280 9.93e-01
Cellular responses to external stimuli 400 9.11e-01 0.003260 9.84e-01
Intracellular signaling by second messengers 277 9.30e-01 0.003060 9.90e-01
NOTCH3 Intracellular Domain Regulates Transcription 23 9.80e-01 0.003020 9.93e-01
VEGFR2 mediated cell proliferation 19 9.82e-01 0.002980 9.93e-01
Metabolism of RNA 508 9.10e-01 -0.002940 9.84e-01
Negative epigenetic regulation of rRNA expression 37 9.76e-01 -0.002890 9.93e-01
GPVI-mediated activation cascade 29 9.81e-01 0.002580 9.93e-01
SRP-dependent cotranslational protein targeting to membrane 63 9.76e-01 -0.002170 9.93e-01
Bile acid and bile salt metabolism 36 9.83e-01 -0.002000 9.93e-01
Interferon alpha/beta signaling 55 9.80e-01 0.001960 9.93e-01
Signaling by BRAF and RAF fusions 58 9.80e-01 0.001940 9.93e-01
G alpha (z) signalling events 41 9.84e-01 0.001860 9.93e-01
IRS-mediated signalling 45 9.85e-01 -0.001570 9.93e-01
Interleukin-4 and Interleukin-13 signaling 105 9.80e-01 0.001430 9.93e-01
FCGR3A-mediated phagocytosis 64 9.85e-01 -0.001360 9.93e-01
Leishmania phagocytosis 64 9.85e-01 -0.001360 9.93e-01
Parasite infection 64 9.85e-01 -0.001360 9.93e-01
RAB GEFs exchange GTP for GDP on RABs 80 9.85e-01 -0.001230 9.93e-01
Signaling by high-kinase activity BRAF mutants 33 9.91e-01 0.001140 9.98e-01
Nuclear Events (kinase and transcription factor activation) 61 9.95e-01 -0.000492 9.99e-01
RAB geranylgeranylation 54 9.96e-01 0.000401 9.99e-01
Class A/1 (Rhodopsin-like receptors) 288 9.92e-01 0.000324 9.99e-01
Diseases associated with visual transduction 11 9.99e-01 -0.000295 9.99e-01
Diseases of the neuronal system 11 9.99e-01 -0.000295 9.99e-01
Retinoid cycle disease events 11 9.99e-01 -0.000295 9.99e-01
Adenylate cyclase activating pathway 10 9.99e-01 0.000220 9.99e-01
Energy dependent regulation of mTOR by LKB1-AMPK 25 9.99e-01 -0.000203 9.99e-01
Na+/Cl- dependent neurotransmitter transporters 17 9.99e-01 0.000176 9.99e-01
Interferon Signaling 150 9.98e-01 -0.000148 9.99e-01


Detailed Gene set reports



Olfactory Signaling Pathway

Olfactory Signaling Pathway
775
set Olfactory Signaling Pathway
setSize 279
pANOVA 4.49e-71
s.dist 0.619
p.adjustANOVA 6.25e-68



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR5P2 7120.0
OR4C15 7094.0
OR2AG1 7092.5
OR2AG2 7092.5
OR1E1 7090.5
OR1E2 7090.5
OR5B3 7089.0
OR4A16 7082.5
OR4A5 7082.5
OR5W2 7071.0
OR8K3 7070.0
OR7G2 7043.0
OR8K5 7042.0
OR14A2 7039.0
OR7E24 7031.0
OR5AN1 7030.0
OR10A3 7023.5
OR10A6 7023.5
OR8H1 7021.0
OR8H2 7021.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR5P2 7120.0
OR4C15 7094.0
OR2AG1 7092.5
OR2AG2 7092.5
OR1E1 7090.5
OR1E2 7090.5
OR5B3 7089.0
OR4A16 7082.5
OR4A5 7082.5
OR5W2 7071.0
OR8K3 7070.0
OR7G2 7043.0
OR8K5 7042.0
OR14A2 7039.0
OR7E24 7031.0
OR5AN1 7030.0
OR10A3 7023.5
OR10A6 7023.5
OR8H1 7021.0
OR8H2 7021.0
OR8H3 7021.0
OR7D4 7015.0
OR4C16 7013.0
OR5T2 7005.0
OR8D1 7004.0
OR52N2 7003.0
OR9G1 7002.0
OR2AJ1 6991.0
OR8B2 6989.5
OR8B3 6989.5
OR5T1 6985.5
OR5T3 6985.5
OR52R1 6983.0
OR5K4 6978.0
OR9I1 6975.0
OR4K15 6972.0
OR4C12 6971.0
OR4D10 6969.0
OR5D18 6957.0
OR4C11 6955.0
OR8B12 6947.0
OR52A5 6945.0
OR10AG1 6941.0
OR2A1 6937.5
OR4L1 6934.0
OR2F1 6932.5
OR2F2 6932.5
OR2A14 6930.0
OR2T29 6928.0
OR2T4 6928.0
OR2T5 6928.0
OR4B1 6919.0
OR6C1 6914.0
OR5D14 6913.0
OR4N4 6912.0
OR10J3 6892.5
OR10J4 6892.5
OR5M11 6889.0
OR6C76 6882.0
OR13G1 6879.0
OR6C70 6878.0
OR6C6 6877.0
OR5V1 6871.0
OR5P3 6867.0
OR1N1 6851.0
OR8D2 6840.0
OR5AK2 6824.0
OR8I2 6815.0
OR5M1 6804.5
OR5M10 6804.5
OR1A1 6800.0
OR9K2 6789.0
OR11H4 6734.0
OR5B12 6722.0
OR4A47 6715.0
OR56A4 6705.0
OR4K2 6692.0
OR3A1 6691.0
OR5AP2 6677.0
OR2W1 6656.0
OR4X2 6591.0
OR1S1 6553.5
OR1S2 6553.5
OR10A2 6549.5
OR10A5 6549.5
OR6F1 6548.0
OR51A7 6529.0
OR6C3 6528.0
OR2AP1 6510.0
OR4P4 6488.0
OR56B1 6480.0
OR10X1 6479.0
OR6C75 6475.0
OR4F15 6452.0
OR14J1 6443.0
OR5AS1 6413.0
OR8B4 6394.0
OR11A1 6392.0
OR5M3 6356.0
OR8B8 6331.0
OR2A12 6322.0
OR8J1 6315.5
OR8J3 6315.5
OR2T2 6267.5
OR2T35 6267.5
OR12D2 6262.5
OR51F1 6261.0
OR4K1 6257.0
OR5B2 6193.0
OR1C1 6188.0
OR2V2 6187.0
OR1Q1 6179.0
OR5B21 6176.0
OR5D16 6167.0
OR4K5 6136.0
OR5M8 6112.0
OR10Q1 6104.0
OR8A1 6102.0
OR51E2 6091.0
OR4N5 6079.0
OR51G2 6041.0
OR4C5 5984.0
OR51Q1 5960.0
OR6N1 5891.0
OR11H7 5845.0
OR6K6 5804.0
OR6N2 5788.0
OR6C65 5699.0
OR10G4 5629.5
OR10G7 5629.5
OR10G8 5629.5
OR10G9 5629.5
OR1L4 5589.5
OR1L6 5589.5
OR6C68 5541.0
OR1L8 5536.0
OR10J5 5494.0
OR10H1 5448.0
OR10H2 5448.0
OR10H5 5448.0
OR1F1 5427.0
GNGT1 5409.0
OR6C2 5401.0
OR9G4 5397.0
OR52E6 5339.5
OR52E8 5339.5
OR1J1 5325.0
OR9Q1 5316.0
OR52N5 5310.0
OR6K3 5228.0
OR9Q2 5193.0
OR10D3 5138.0
OR10J1 5084.0
OR13A1 5049.0
OR1M1 5040.0
OR4F17 5020.0
OR4F4 5020.0
OR4F5 5020.0
OR10G2 4978.0
OR8K1 4863.0
OR11H6 4806.0
OR2J1 4793.5
OR2J2 4793.5
OR10P1 4744.0
OR13H1 4690.0
OR2AK2 4678.0
OR5L1 4674.5
OR5L2 4674.5
OR13C8 4624.0
OR2D2 4587.0
OR51F2 4473.0
OR5AR1 4468.0
OR6C74 4258.0
OR2A5 4176.0
OR52E2 4154.0
OR5J2 4065.0
OR2L2 4044.5
OR2L3 4044.5
OR2L5 4044.5
OR2L8 4044.5
OR51B4 4039.0
REEP5 4002.0
OR13F1 3879.0
OR4D11 3827.0
OR52I1 3825.5
OR52I2 3825.5
OR2K2 3822.0
OR2D3 3806.0
OR52J3 3782.0
OR4Q3 3625.0
OR51I2 3608.0
OR10W1 3576.0
OR5A2 3479.0
OR2A2 3405.0
OR2A4 3400.5
OR2A7 3400.5
OR2A25 3279.0
OR5I1 3155.0
OR10V1 3147.0
OR2T6 3122.0
OR51S1 3112.0
OR8U1 2997.0
OR1I1 2950.0
OR8D4 2945.0
OR4M1 2797.5
OR4M2 2797.5
OR12D3 2755.0
OR4A15 2744.0
RTP4 2690.0
OR7C2 2505.0
OR51T1 2455.0
REEP1 2363.0
OR51G1 2281.0
OR51I1 2222.0
OR4S2 2172.0
OR9A4 2098.0
OR13D1 2086.0
OR10A4 2023.0
OR9A2 1784.0
OR6B1 1667.0
OR10C1 1665.0
OR52W1 1586.0
OR10K2 1517.0
OR10H3 1513.5
OR10H4 1513.5
OR10Z1 1476.0
OR13C3 1390.0
OR6A2 1363.0
OR6P1 1290.0
OR4D6 1175.0
OR52E4 943.0
RTP3 878.0
OR52L1 821.0
GNB1 691.0
OR1J4 626.0
OR51M1 493.0
OR6Y1 445.0
OR6X1 421.0
OR4D5 390.0
OR2C1 240.0
OR51E1 -6.0
OR2T1 -117.0
OR6K2 -288.0
OR4C3 -321.0
OR5C1 -642.0
OR52M1 -759.0
OR5A1 -933.0
OR4E2 -1509.0
OR52B2 -1744.0
REEP6 -2376.0
OR2B6 -2507.0
GNAL -2784.0
OR10S1 -3125.0
OR51D1 -3482.0
OR2B11 -3547.0
OR4D1 -3775.0
OR6B2 -3909.5
OR6B3 -3909.5
OR52K2 -3928.0
OR7G3 -3992.0
OR52H1 -4185.0
OR2AT4 -4534.0
OR5AU1 -5169.0
RTP1 -5259.0
RTP2 -5372.0
OR10AD1 -5541.0
OR2T12 -6036.0
OR2T33 -6036.0
OR2T8 -6036.0
OR52N4 -6095.0
OR6S1 -6232.0
OR13J1 -6384.0
OR52D1 -6603.0
REEP2 -6911.0
OR11L1 -6953.0
REEP4 -7744.0
OR2W3 -8042.0
OR10G3 -8743.0
OR4D2 -8795.0


Glucuronidation

Glucuronidation
469
set Glucuronidation
setSize 17
pANOVA 0.000153
s.dist 0.53
p.adjustANOVA 0.0233



Top enriched genes

Top 20 genes
GeneID Gene Rank
UGT2A1 6946.0
UGT1A10 6902.5
UGT1A7 6902.5
UGT1A8 6902.5
UGT1A9 6902.5
UGP2 6147.0
ABHD10 4873.0
UGT1A6 3489.0
UGT1A3 3139.0
UGT1A4 3139.0
UGT1A5 3139.0
SLC35D1 2383.0
UGT3A1 1563.5
UGT3A2 1563.5
UGT2A3 800.0
UGT1A1 -1211.0
UGDH -7867.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UGT2A1 6946.0
UGT1A10 6902.5
UGT1A7 6902.5
UGT1A8 6902.5
UGT1A9 6902.5
UGP2 6147.0
ABHD10 4873.0
UGT1A6 3489.0
UGT1A3 3139.0
UGT1A4 3139.0
UGT1A5 3139.0
SLC35D1 2383.0
UGT3A1 1563.5
UGT3A2 1563.5
UGT2A3 800.0
UGT1A1 -1211.0
UGDH -7867.0


Passive transport by Aquaporins

Passive transport by Aquaporins
820
set Passive transport by Aquaporins
setSize 12
pANOVA 0.0046
s.dist -0.472
p.adjustANOVA 0.297



Top enriched genes

Top 20 genes
GeneID Gene Rank
AQP6 -8056.0
AQP7 -7985.0
AQP12A -7323.5
AQP5 -6991.0
AQP3 -6778.0
AQP2 -6548.0
MIP -6512.0
AQP11 -4084.0
AQP8 -3967.0
AQP9 -2696.0
AQP1 -2564.0
AQP4 4553.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AQP6 -8056.0
AQP7 -7985.0
AQP12A -7323.5
AQP5 -6991.0
AQP3 -6778.0
AQP2 -6548.0
MIP -6512.0
AQP11 -4084.0
AQP8 -3967.0
AQP9 -2696.0
AQP1 -2564.0
AQP4 4553.0


TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation
1238
set TRAF6 mediated IRF7 activation
setSize 28
pANOVA 2.21e-05
s.dist 0.463
p.adjustANOVA 0.00385



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA1 7051
IFNA10 7051
IFNA14 7051
IFNA16 7051
IFNA17 7051
IFNA2 7051
IFNA21 7051
IFNA4 7051
IFNA5 7051
IFNA6 7051
IFNA7 7051
IFNA8 7051
TANK 6503
IFNB1 5508
SIKE1 4119
TRAF6 3268
IFIH1 2897
EP300 1892
CREBBP 1152
TRAF2 81

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA1 7051
IFNA10 7051
IFNA14 7051
IFNA16 7051
IFNA17 7051
IFNA2 7051
IFNA21 7051
IFNA4 7051
IFNA5 7051
IFNA6 7051
IFNA7 7051
IFNA8 7051
TANK 6503
IFNB1 5508
SIKE1 4119
TRAF6 3268
IFIH1 2897
EP300 1892
CREBBP 1152
TRAF2 81
MAVS -1815
IRF7 -1820
RNF135 -1885
TRIM25 -2820
TBK1 -5984
IRF3 -6107
DDX58 -6505
IKBKE -6765


G alpha (s) signalling events

G alpha (s) signalling events
417
set G alpha (s) signalling events
setSize 408
pANOVA 4.62e-50
s.dist 0.429
p.adjustANOVA 3.21e-47



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR5P2 7120.0
OR4C15 7094.0
OR2AG1 7092.5
OR2AG2 7092.5
OR1E1 7090.5
OR1E2 7090.5
OR5B3 7089.0
OR4A16 7082.5
OR4A5 7082.5
OR5W2 7071.0
OR8K3 7070.0
OR7G2 7043.0
OR8K5 7042.0
OR14A2 7039.0
OR7E24 7031.0
OR5AN1 7030.0
OR10A3 7023.5
OR10A6 7023.5
OR8H1 7021.0
OR8H2 7021.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR5P2 7120.0
OR4C15 7094.0
OR2AG1 7092.5
OR2AG2 7092.5
OR1E1 7090.5
OR1E2 7090.5
OR5B3 7089.0
OR4A16 7082.5
OR4A5 7082.5
OR5W2 7071.0
OR8K3 7070.0
OR7G2 7043.0
OR8K5 7042.0
OR14A2 7039.0
OR7E24 7031.0
OR5AN1 7030.0
OR10A3 7023.5
OR10A6 7023.5
OR8H1 7021.0
OR8H2 7021.0
OR8H3 7021.0
OR7D4 7015.0
OR4C16 7013.0
OR5T2 7005.0
OR8D1 7004.0
OR52N2 7003.0
OR9G1 7002.0
OR2AJ1 6991.0
OR8B2 6989.5
OR8B3 6989.5
OR5T1 6985.5
OR5T3 6985.5
OR52R1 6983.0
OR5K4 6978.0
OR9I1 6975.0
OR4K15 6972.0
OR4C12 6971.0
OR4D10 6969.0
OR5D18 6957.0
OR4C11 6955.0
OR8B12 6947.0
OR52A5 6945.0
OR10AG1 6941.0
OR2A1 6937.5
OR4L1 6934.0
OR2F1 6932.5
OR2F2 6932.5
OR2A14 6930.0
OR2T29 6928.0
OR2T4 6928.0
OR2T5 6928.0
OR4B1 6919.0
OR6C1 6914.0
OR5D14 6913.0
OR4N4 6912.0
OR10J3 6892.5
OR10J4 6892.5
OR5M11 6889.0
OR6C76 6882.0
OR13G1 6879.0
OR6C70 6878.0
OR6C6 6877.0
OR5V1 6871.0
OR5P3 6867.0
OR1N1 6851.0
OR8D2 6840.0
OR5AK2 6824.0
OR8I2 6815.0
OR5M1 6804.5
OR5M10 6804.5
OR1A1 6800.0
OR9K2 6789.0
PDE3B 6785.0
OR11H4 6734.0
OR5B12 6722.0
OR4A47 6715.0
OR56A4 6705.0
OR4K2 6692.0
OR3A1 6691.0
OR5AP2 6677.0
CALCR 6675.0
OR2W1 6656.0
OR4X2 6591.0
OR1S1 6553.5
OR1S2 6553.5
OR10A2 6549.5
OR10A5 6549.5
OR6F1 6548.0
OR51A7 6529.0
OR6C3 6528.0
OR2AP1 6510.0
OR4P4 6488.0
OR56B1 6480.0
OR10X1 6479.0
OR6C75 6475.0
OR4F15 6452.0
OR14J1 6443.0
OR5AS1 6413.0
OR8B4 6394.0
OR11A1 6392.0
OR5M3 6356.0
OR8B8 6331.0
OR2A12 6322.0
OR8J1 6315.5
OR8J3 6315.5
OR2T2 6267.5
OR2T35 6267.5
OR12D2 6262.5
OR51F1 6261.0
OR4K1 6257.0
OR5B2 6193.0
OR1C1 6188.0
OR2V2 6187.0
OR1Q1 6179.0
OR5B21 6176.0
OR5D16 6167.0
OR4K5 6136.0
OR5M8 6112.0
OR10Q1 6104.0
OR8A1 6102.0
ADCYAP1 6097.0
OR51E2 6091.0
OR4N5 6079.0
OR51G2 6041.0
OR4C5 5984.0
PDE7A 5973.0
GNG11 5968.0
OR51Q1 5960.0
OR6N1 5891.0
OR11H7 5845.0
GPR150 5834.0
PTGER2 5815.0
OR6K6 5804.0
OR6N2 5788.0
CALCRL 5768.0
OR6C65 5699.0
OR10G4 5629.5
OR10G7 5629.5
OR10G8 5629.5
OR10G9 5629.5
OR1L4 5589.5
OR1L6 5589.5
PTH2R 5582.0
OR6C68 5541.0
OR1L8 5536.0
OR10J5 5494.0
PDE1A 5462.0
OR10H1 5448.0
OR10H2 5448.0
OR10H5 5448.0
OR1F1 5427.0
GNGT1 5409.0
OR6C2 5401.0
OR9G4 5397.0
GNAT3 5366.0
OR52E6 5339.5
OR52E8 5339.5
OR1J1 5325.0
OR9Q1 5316.0
OR52N5 5310.0
OR6K3 5228.0
OR9Q2 5193.0
OR10D3 5138.0
OR10J1 5084.0
CRH 5077.0
OR13A1 5049.0
OR1M1 5040.0
OR4F17 5020.0
OR4F4 5020.0
OR4F5 5020.0
OR10G2 4978.0
ADCY2 4943.0
OR8K1 4863.0
OR11H6 4806.0
OR2J1 4793.5
OR2J2 4793.5
CALCA 4781.0
OR10P1 4744.0
OR13H1 4690.0
OR2AK2 4678.0
OR5L1 4674.5
OR5L2 4674.5
OR13C8 4624.0
PDE4D 4590.0
OR2D2 4587.0
TAAR8 4567.0
GNAI3 4522.0
PTH 4515.0
OR51F2 4473.0
OR5AR1 4468.0
GNAI1 4379.0
NPSR1 4313.0
OR6C74 4258.0
ADCY8 4229.0
ADCY1 4198.0
OR2A5 4176.0
OR52E2 4154.0
OR5J2 4065.0
OR2L2 4044.5
OR2L3 4044.5
OR2L5 4044.5
OR2L8 4044.5
OR51B4 4039.0
REEP5 4002.0
PTGER4 3882.0
OR13F1 3879.0
LHCGR 3840.0
GRK6 3834.0
OR4D11 3827.0
OR52I1 3825.5
OR52I2 3825.5
OR2K2 3822.0
OR2D3 3806.0
OR52J3 3782.0
GNG2 3663.0
OR4Q3 3625.0
OR51I2 3608.0
GNG4 3607.0
OR10W1 3576.0
RAMP2 3512.0
GRK5 3504.0
OR5A2 3479.0
CYSLTR2 3448.0
TAAR1 3423.0
OR2A2 3405.0
OR2A4 3400.5
OR2A7 3400.5
ADORA2A 3386.0
GCG 3328.0
OR2A25 3279.0
TSHB 3252.0
OR5I1 3155.0
OR10V1 3147.0
OR2T6 3122.0
OR51S1 3112.0
PDE8A 3099.0
OR8U1 2997.0
PDE7B 2971.0
OR1I1 2950.0
OR8D4 2945.0
DRD5 2812.0
OR4M1 2797.5
OR4M2 2797.5
OR12D3 2755.0
OR4A15 2744.0
HTR7 2723.0
IAPP 2693.0
RTP4 2690.0
RXFP1 2664.0
OR7C2 2505.0
OR51T1 2455.0
REEP1 2363.0
CALCB 2311.0
OR51G1 2281.0
PTHLH 2270.0
ADCY4 2226.0
OR51I1 2222.0
OR4S2 2172.0
OR9A4 2098.0
OR13D1 2086.0
OR10A4 2023.0
VIP 1879.0
PDE1B 1796.0
OR9A2 1784.0
OR6B1 1667.0
OR10C1 1665.0
VIPR2 1599.0
OR52W1 1586.0
FSHB 1532.0
OR10K2 1517.0
OR10H3 1513.5
OR10H4 1513.5
OR10Z1 1476.0
OR13C3 1390.0
OR6A2 1363.0
OR6P1 1290.0
OR4D6 1175.0
GNAI2 1164.0
ADRB2 1072.0
OR52E4 943.0
RTP3 878.0
OR52L1 821.0
ADCY9 745.0
GNB1 691.0
OR1J4 626.0
TAAR6 501.0
OR51M1 493.0
OR6Y1 445.0
TAAR9 439.0
OR6X1 421.0
OR4D5 390.0
GPR15 283.0
PDE3A 271.0
OR2C1 240.0
OR51E1 -6.0
OR2T1 -117.0
POMC -215.0
OR6K2 -288.0
OR4C3 -321.0
PTH2 -406.0
FSHR -432.0
MC4R -458.0
OR5C1 -642.0
OR52M1 -759.0
OR5A1 -933.0
GPR27 -936.0
GIPR -965.0
NPS -978.0
TAAR2 -1188.0
HRH2 -1227.0
TAAR5 -1488.0
OR4E2 -1509.0
GPR25 -1556.0
MC2R -1573.0
TSHR -1606.0
OR52B2 -1744.0
CRHR2 -1834.0
GPR176 -1877.0
ADRB1 -1929.0
GLP1R -2167.0
GPBAR1 -2187.0
PDE8B -2240.0
CRHR1 -2254.0
GNG8 -2264.0
SCTR -2267.0
REEP6 -2376.0
OR2B6 -2507.0
ARRB2 -2547.0
HTR4 -2719.0
GNAL -2784.0
RLN2 -2852.5
GPR45 -2863.0
ADRB3 -2867.0
GNG10 -3056.0
OR10S1 -3125.0
ADCY6 -3142.0
GNG13 -3237.0
RLN3 -3256.0
GNB4 -3321.0
GLP2R -3346.0
OR51D1 -3482.0
RAMP1 -3522.0
OR2B11 -3547.0
CGA -3665.0
OR4D1 -3775.0
GHRHR -3813.0
ADCY5 -3841.0
OR6B2 -3909.5
OR6B3 -3909.5
OR52K2 -3928.0
AVP -3990.0
OR7G3 -3992.0
OR52H1 -4185.0
PDE11A -4205.0
ADORA2B -4228.0
ADCYAP1R1 -4238.0
OR2AT4 -4534.0
GPR20 -4545.0
PDE2A -4578.0
DRD1 -4585.0
SCT -4622.0
PTH1R -4720.0
AVPR2 -4747.0
ARRB1 -4917.0
ADM -5101.0
OR5AU1 -5169.0
GPR83 -5187.0
RTP1 -5259.0
GPR84 -5335.0
RTP2 -5372.0
GPR39 -5390.0
MC5R -5505.0
OR10AD1 -5541.0
INSL3 -5599.0
GNB5 -5643.0
MC1R -5805.0
OR2T12 -6036.0
OR2T33 -6036.0
OR2T8 -6036.0
OR52N4 -6095.0
OR6S1 -6232.0
OR13J1 -6384.0
MC3R -6577.0
OR52D1 -6603.0
GNAS -6635.0
GIP -6657.0
HTR6 -6826.0
VIPR1 -6828.0
REEP2 -6911.0
OR11L1 -6953.0
GHRH -7284.0
ADM2 -7458.0
PDE10A -7478.0
SRC -7505.0
REEP4 -7744.0
GNB3 -7843.0
RXFP2 -7938.0
GNG7 -7958.0
GNAZ -7968.0
OR2W3 -8042.0
GPHA2 -8107.0
ADCY7 -8353.0
ADCY3 -8738.0
OR10G3 -8743.0
PTGIR -8769.0
OR4D2 -8795.0
PDE4A -8849.0
PDE4C -8955.0


Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)
193
set Class C/3 (Metabotropic glutamate/pheromone receptors)
setSize 34
pANOVA 1.62e-05
s.dist 0.427
p.adjustANOVA 0.00321



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAS2R14 7088
TAS2R13 7012
TAS2R19 6908
TAS2R20 6908
TAS2R30 6908
TAS2R31 6908
TAS2R43 6908
TAS2R46 6908
TAS2R50 6908
GRM3 6777
GRM5 6735
TAS2R10 6231
GRM8 5703
GRM7 5642
GPRC6A 5581
TAS2R1 5209
TAS2R3 4645
TAS2R42 4527
TAS2R16 3983
TAS2R41 3870

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAS2R14 7088
TAS2R13 7012
TAS2R19 6908
TAS2R20 6908
TAS2R30 6908
TAS2R31 6908
TAS2R43 6908
TAS2R46 6908
TAS2R50 6908
GRM3 6777
GRM5 6735
TAS2R10 6231
GRM8 5703
GRM7 5642
GPRC6A 5581
TAS2R1 5209
TAS2R3 4645
TAS2R42 4527
TAS2R16 3983
TAS2R41 3870
TAS2R38 3839
TAS2R7 3291
TAS2R60 3091
TAS2R39 2388
GRM1 409
TAS2R40 -1608
CASR -2774
GABBR2 -3012
TAS1R3 -5258
GRM6 -6274
TAS1R2 -7810
GRM4 -7906
GABBR1 -8250
GRM2 -8786


PI3K events in ERBB4 signaling

PI3K events in ERBB4 signaling
802
set PI3K events in ERBB4 signaling
setSize 10
pANOVA 0.0204
s.dist 0.423
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
ERBB4 6841
NRG1 5376
NRG3 5354
EREG 3888
PIK3R1 3668
BTC 3507
NRG4 755
NRG2 -1156
HBEGF -1977
PIK3CA -2203

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ERBB4 6841
NRG1 5376
NRG3 5354
EREG 3888
PIK3R1 3668
BTC 3507
NRG4 755
NRG2 -1156
HBEGF -1977
PIK3CA -2203


Removal of the Flap Intermediate

Removal of the Flap Intermediate
1017
set Removal of the Flap Intermediate
setSize 11
pANOVA 0.016
s.dist -0.419
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD1 -9075
DNA2 -8862
POLD2 -8726
RPA2 -8622
PRIM1 -7779
POLA2 -5833
PCNA -5055
RPA1 -1771
PRIM2 -50
POLD3 1469
POLA1 5038

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD1 -9075
DNA2 -8862
POLD2 -8726
RPA2 -8622
PRIM1 -7779
POLA2 -5833
PCNA -5055
RPA1 -1771
PRIM2 -50
POLD3 1469
POLA1 5038


SHC1 events in ERBB4 signaling

SHC1 events in ERBB4 signaling
1058
set SHC1 events in ERBB4 signaling
setSize 14
pANOVA 0.00762
s.dist 0.412
p.adjustANOVA 0.374



Top enriched genes

Top 20 genes
GeneID Gene Rank
ERBB4 6841
NRAS 5491
NRG1 5376
NRG3 5354
KRAS 4959
EREG 3888
BTC 3507
GRB2 2365
NRG4 755
HRAS 209
NRG2 -1156
SHC1 -1493
SOS1 -1772
HBEGF -1977

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ERBB4 6841
NRAS 5491
NRG1 5376
NRG3 5354
KRAS 4959
EREG 3888
BTC 3507
GRB2 2365
NRG4 755
HRAS 209
NRG2 -1156
SHC1 -1493
SOS1 -1772
HBEGF -1977


Regulation of IFNA signaling

Regulation of IFNA signaling
973
set Regulation of IFNA signaling
setSize 25
pANOVA 0.000486
s.dist 0.403
p.adjustANOVA 0.052



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA1 7051
IFNA10 7051
IFNA14 7051
IFNA16 7051
IFNA17 7051
IFNA2 7051
IFNA21 7051
IFNA4 7051
IFNA5 7051
IFNA6 7051
IFNA7 7051
IFNA8 7051
IFNB1 5508
SOCS1 2387
JAK1 1554
IFNAR1 847
STAT2 -781
STAT1 -1859
PTPN1 -2109
PTPN11 -2492

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA1 7051.0
IFNA10 7051.0
IFNA14 7051.0
IFNA16 7051.0
IFNA17 7051.0
IFNA2 7051.0
IFNA21 7051.0
IFNA4 7051.0
IFNA5 7051.0
IFNA6 7051.0
IFNA7 7051.0
IFNA8 7051.0
IFNB1 5508.0
SOCS1 2387.0
JAK1 1554.0
IFNAR1 847.0
STAT2 -781.0
STAT1 -1859.0
PTPN1 -2109.0
PTPN11 -2492.0
USP18 -4333.5
IFNAR2 -5214.0
TYK2 -6660.0
SOCS3 -6938.0
PTPN6 -8620.0


Diseases associated with glycosylation precursor biosynthesis

Diseases associated with glycosylation precursor biosynthesis
292
set Diseases associated with glycosylation precursor biosynthesis
setSize 16
pANOVA 0.00547
s.dist -0.401
p.adjustANOVA 0.331



Top enriched genes

Top 20 genes
GeneID Gene Rank
CTSA -9110.0
GALE -8957.0
DHDDS -8835.0
NEU1 -8439.0
SRD5A3 -8419.0
GNE -7079.0
GALK1 -6886.0
DPM1 -6145.0
MPI -5468.0
PGM1 -3767.0
GALT -2461.5
PMM2 -895.0
GFPT1 -342.0
DPM3 1347.0
DPM2 2129.0
NUS1 4064.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSA -9110.0
GALE -8957.0
DHDDS -8835.0
NEU1 -8439.0
SRD5A3 -8419.0
GNE -7079.0
GALK1 -6886.0
DPM1 -6145.0
MPI -5468.0
PGM1 -3767.0
GALT -2461.5
PMM2 -895.0
GFPT1 -342.0
DPM3 1347.0
DPM2 2129.0
NUS1 4064.0


ATF6 (ATF6-alpha) activates chaperones

ATF6 (ATF6-alpha) activates chaperones
19
set ATF6 (ATF6-alpha) activates chaperones
setSize 10
pANOVA 0.0294
s.dist 0.398
p.adjustANOVA 0.439



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPA5 5620
NFYC 5412
MBTPS2 4249
ATF4 4245
ATF6 4203
HSP90B1 4163
NFYA 1594
MBTPS1 -442
XBP1 -2549
NFYB -4531

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 5620
NFYC 5412
MBTPS2 4249
ATF4 4245
ATF6 4203
HSP90B1 4163
NFYA 1594
MBTPS1 -442
XBP1 -2549
NFYB -4531


Glutathione synthesis and recycling

Glutathione synthesis and recycling
474
set Glutathione synthesis and recycling
setSize 12
pANOVA 0.018
s.dist -0.394
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
OPLAH -9057
GGT1 -8800
GGT6 -8757
GGT7 -7224
GGT5 -7220
CHAC1 -7129
CNDP2 -4417
GGCT -3618
GSS -709
GCLC -358
GCLM 1033
CHAC2 4951

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OPLAH -9057
GGT1 -8800
GGT6 -8757
GGT7 -7224
GGT5 -7220
CHAC1 -7129
CNDP2 -4417
GGCT -3618
GSS -709
GCLC -358
GCLM 1033
CHAC2 4951


IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
525
set IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
setSize 12
pANOVA 0.0195
s.dist 0.39
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAB2 6463.0
TLR4 5985.0
MAP3K7 5044.0
LY96 4026.0
TAB3 4017.0
TRAF6 3268.0
TICAM2 3184.5
UBA52 1870.0
TICAM1 675.0
CD14 227.0
TAB1 -2561.0
IRAK2 -6655.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAB2 6463.0
TLR4 5985.0
MAP3K7 5044.0
LY96 4026.0
TAB3 4017.0
TRAF6 3268.0
TICAM2 3184.5
UBA52 1870.0
TICAM1 675.0
CD14 227.0
TAB1 -2561.0
IRAK2 -6655.0


GRB2 events in ERBB2 signaling

GRB2 events in ERBB2 signaling
445
set GRB2 events in ERBB2 signaling
setSize 16
pANOVA 0.00719
s.dist 0.388
p.adjustANOVA 0.374



Top enriched genes

Top 20 genes
GeneID Gene Rank
ERBB4 6841
NRAS 5491
EGFR 5410
NRG1 5376
NRG3 5354
KRAS 4959
EREG 3888
BTC 3507
GRB2 2365
EGF 1889
NRG4 755
HRAS 209
NRG2 -1156
SOS1 -1772
HBEGF -1977
ERBB2 -7283

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ERBB4 6841
NRAS 5491
EGFR 5410
NRG1 5376
NRG3 5354
KRAS 4959
EREG 3888
BTC 3507
GRB2 2365
EGF 1889
NRG4 755
HRAS 209
NRG2 -1156
SOS1 -1772
HBEGF -1977
ERBB2 -7283


CREB1 phosphorylation through the activation of Adenylate Cyclase

CREB1 phosphorylation through the activation of Adenylate Cyclase
139
set CREB1 phosphorylation through the activation of Adenylate Cyclase
setSize 11
pANOVA 0.0269
s.dist 0.385
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKX 5235
CREB1 4499
ADCY8 4229
ADCY1 4198
PRKAR2B 3621
CALM1 2961
PRKACB 2922
PRKAR2A 1973
PRKACA 303
PRKAR1A -1287
PRKAR1B -5621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKX 5235
CREB1 4499
ADCY8 4229
ADCY1 4198
PRKAR2B 3621
CALM1 2961
PRKACB 2922
PRKAR2A 1973
PRKACA 303
PRKAR1A -1287
PRKAR1B -5621


Synthesis of PA

Synthesis of PA
1192
set Synthesis of PA
setSize 30
pANOVA 0.000268
s.dist -0.384
p.adjustANOVA 0.0339



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALPI -9214
PLD2 -8938
AGPAT1 -8913
PLA2G1B -8445
GNPAT -8171
GPD1 -7921
PLA2G5 -7617
LPCAT4 -7301
PLA2G2D -7131
GPD1L -7062
PLA2G2F -6730
GPAT2 -6614
AGPAT4 -5666
PLA2G2E -5483
PLD6 -5121
PLA2R1 -4923
ACP6 -4904
PLA2G12A -4250
LIPH -3356
LPCAT1 -2488

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALPI -9214
PLD2 -8938
AGPAT1 -8913
PLA2G1B -8445
GNPAT -8171
GPD1 -7921
PLA2G5 -7617
LPCAT4 -7301
PLA2G2D -7131
GPD1L -7062
PLA2G2F -6730
GPAT2 -6614
AGPAT4 -5666
PLA2G2E -5483
PLD6 -5121
PLA2R1 -4923
ACP6 -4904
PLA2G12A -4250
LIPH -3356
LPCAT1 -2488
AGPAT2 -2231
PLA2G4D -2011
DDHD1 -1900
PLD1 -1714
AGPAT3 -1623
GPD2 277
AGPAT5 1928
LCLAT1 2146
PLA2G4A 3973
GPAM 5692


Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis
692
set Mitotic Telophase/Cytokinesis
setSize 10
pANOVA 0.0358
s.dist 0.383
p.adjustANOVA 0.469



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAG1 5580
RAD21 5519
NIPBL 4783
KIF23 3861
PDS5B 3739
STAG2 3040
SMC1A 2320
KIF20A 153
PDS5A -2346
SMC3 -5863

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 5580
RAD21 5519
NIPBL 4783
KIF23 3861
PDS5B 3739
STAG2 3040
SMC1A 2320
KIF20A 153
PDS5A -2346
SMC3 -5863


Adherens junctions interactions

Adherens junctions interactions
65
set Adherens junctions interactions
setSize 24
pANOVA 0.0012
s.dist 0.382
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDH7 6822
CDH10 6750
CDH9 6657
CADM2 6651
CDH11 6441
CDH18 6299
CDH2 6055
CDH8 5417
ANG 5192
CDH12 5113
CDH17 4109
CTNND1 3831
CTNNA1 3807
CDH6 3664
CADM1 3296
CADM3 1799
CTNNB1 1225
CDH3 12
CDH1 -1398
CDH5 -4900

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDH7 6822
CDH10 6750
CDH9 6657
CADM2 6651
CDH11 6441
CDH18 6299
CDH2 6055
CDH8 5417
ANG 5192
CDH12 5113
CDH17 4109
CTNND1 3831
CTNNA1 3807
CDH6 3664
CADM1 3296
CADM3 1799
CTNNB1 1225
CDH3 12
CDH1 -1398
CDH5 -4900
CDH15 -5595
CDH13 -5750
CDH4 -7414
JUP -8552


GRB2 events in EGFR signaling

GRB2 events in EGFR signaling
444
set GRB2 events in EGFR signaling
setSize 13
pANOVA 0.0172
s.dist 0.382
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491.0
EGFR 5410.0
KRAS 4959.0
EREG 3888.0
BTC 3507.0
GRB2 2365.0
EGF 1889.0
EPGN 1733.0
TGFA 1407.0
HRAS 209.0
AREG -267.5
SOS1 -1772.0
HBEGF -1977.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491.0
EGFR 5410.0
KRAS 4959.0
EREG 3888.0
BTC 3507.0
GRB2 2365.0
EGF 1889.0
EPGN 1733.0
TGFA 1407.0
HRAS 209.0
AREG -267.5
SOS1 -1772.0
HBEGF -1977.0


MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
634
set MET activates RAP1 and RAC1
setSize 11
pANOVA 0.0307
s.dist 0.376
p.adjustANOVA 0.45



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL 6541
HGF 6189
GAB1 4240
RAP1A 3687
MET 3362
GRB2 2365
RAC1 2318
CRK 1832
DOCK7 187
RAP1B 55
RAPGEF1 -8561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL 6541
HGF 6189
GAB1 4240
RAP1A 3687
MET 3362
GRB2 2365
RAC1 2318
CRK 1832
DOCK7 187
RAP1B 55
RAPGEF1 -8561


Metabolism of folate and pterines

Metabolism of folate and pterines
654
set Metabolism of folate and pterines
setSize 14
pANOVA 0.0154
s.dist -0.374
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTHFR -8871.0
FPGS -8494.0
SHMT2 -8425.0
SLC46A1 -8326.0
ALDH1L2 -7253.0
MTHFD2 -7190.0
SLC19A1 -7067.0
SHMT1 -5678.0
FOLR2 -3279.0
ALDH1L1 -1290.0
DHFR 456.5
MTHFD1 639.0
MTHFD2L 2536.0
MTHFS 4748.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTHFR -8871.0
FPGS -8494.0
SHMT2 -8425.0
SLC46A1 -8326.0
ALDH1L2 -7253.0
MTHFD2 -7190.0
SLC19A1 -7067.0
SHMT1 -5678.0
FOLR2 -3279.0
ALDH1L1 -1290.0
DHFR 456.5
MTHFD1 639.0
MTHFD2L 2536.0
MTHFS 4748.5


Dermatan sulfate biosynthesis

Dermatan sulfate biosynthesis
280
set Dermatan sulfate biosynthesis
setSize 11
pANOVA 0.0319
s.dist 0.374
p.adjustANOVA 0.451



Top enriched genes

Top 20 genes
GeneID Gene Rank
DSEL 6844
DCN 5899
VCAN 5365
BCAN 4670
DSE 4578
BGN 2641
UST 1493
NCAN -23
CSPG5 -2239
CHST14 -2584
CSPG4 -4661

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DSEL 6844
DCN 5899
VCAN 5365
BCAN 4670
DSE 4578
BGN 2641
UST 1493
NCAN -23
CSPG5 -2239
CHST14 -2584
CSPG4 -4661


Glutamate and glutamine metabolism

Glutamate and glutamine metabolism
471
set Glutamate and glutamine metabolism
setSize 13
pANOVA 0.0216
s.dist -0.368
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
GLS2 -8715.0
PYCR2 -8453.5
PYCR1 -8202.0
ALDH18A1 -7982.0
GLUL -6015.0
GLUD1 -4348.5
GLUD2 -4348.5
GOT2 -4194.0
PYCRL -3186.0
RIMKLA -2819.0
OAT -2089.0
RIMKLB 1045.0
GLS 6534.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GLS2 -8715.0
PYCR2 -8453.5
PYCR1 -8202.0
ALDH18A1 -7982.0
GLUL -6015.0
GLUD1 -4348.5
GLUD2 -4348.5
GOT2 -4194.0
PYCRL -3186.0
RIMKLA -2819.0
OAT -2089.0
RIMKLB 1045.0
GLS 6534.0


Acyl chain remodelling of PS

Acyl chain remodelling of PS
61
set Acyl chain remodelling of PS
setSize 18
pANOVA 0.00855
s.dist -0.358
p.adjustANOVA 0.374



Top enriched genes

Top 20 genes
GeneID Gene Rank
OSBPL10 -9089
PLA2G1B -8445
LPCAT3 -7783
PLA2G5 -7617
LPCAT4 -7301
PLA2G2D -7131
PLA2G2F -6730
OSBPL5 -5977
PLA2G2E -5483
PLA2R1 -4923
PLA2G12A -4250
PLA1A -4239
PLA2G4D -2011
PLA2G4F -434
PLA2G4E 807
MBOAT1 1142
OSBPL8 3909
PLA2G4A 3973

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OSBPL10 -9089
PLA2G1B -8445
LPCAT3 -7783
PLA2G5 -7617
LPCAT4 -7301
PLA2G2D -7131
PLA2G2F -6730
OSBPL5 -5977
PLA2G2E -5483
PLA2R1 -4923
PLA2G12A -4250
PLA1A -4239
PLA2G4D -2011
PLA2G4F -434
PLA2G4E 807
MBOAT1 1142
OSBPL8 3909
PLA2G4A 3973


Pre-NOTCH Processing in Golgi

Pre-NOTCH Processing in Golgi
868
set Pre-NOTCH Processing in Golgi
setSize 14
pANOVA 0.0208
s.dist -0.357
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH4 -9076
MFNG -8096
FURIN -8045
ST3GAL3 -7923
NOTCH1 -7799
ATP2A1 -7579
ATP2A3 -4137
SEL1L -3864
TMED2 -2242
B4GALT1 -1731
NOTCH3 -1542
LFNG -220
ATP2A2 3174
ST3GAL6 3537

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH4 -9076
MFNG -8096
FURIN -8045
ST3GAL3 -7923
NOTCH1 -7799
ATP2A1 -7579
ATP2A3 -4137
SEL1L -3864
TMED2 -2242
B4GALT1 -1731
NOTCH3 -1542
LFNG -220
ATP2A2 3174
ST3GAL6 3537


ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
334
set ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
setSize 14
pANOVA 0.0218
s.dist -0.354
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
EHMT2 -9212
CHD3 -8990
MTA1 -8619
MTA3 -8170
MTA2 -7441
MBD3 -7021
CHD4 -6350
H2AFX -5715
TTF1 -1611
RBBP7 -1280
GATAD2A -766
HDAC2 2329
GATAD2B 3574
ERCC6 4030

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EHMT2 -9212
CHD3 -8990
MTA1 -8619
MTA3 -8170
MTA2 -7441
MBD3 -7021
CHD4 -6350
H2AFX -5715
TTF1 -1611
RBBP7 -1280
GATAD2A -766
HDAC2 2329
GATAD2B 3574
ERCC6 4030


Aflatoxin activation and detoxification

Aflatoxin activation and detoxification
67
set Aflatoxin activation and detoxification
setSize 16
pANOVA 0.0144
s.dist -0.353
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
DPEP3 -8857.0
GGT1 -8800.0
GGT6 -8757.0
ACY3 -7418.0
GGT7 -7224.0
GGT5 -7220.0
CYP2A13 -7181.0
CYP1A2 -6503.0
DPEP1 -6306.0
ACY1 -6052.5
MGST2 -3758.0
DPEP2 -3462.0
MGST1 654.0
MGST3 3678.0
CYP3A4 7085.5
CYP3A5 7085.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DPEP3 -8857.0
GGT1 -8800.0
GGT6 -8757.0
ACY3 -7418.0
GGT7 -7224.0
GGT5 -7220.0
CYP2A13 -7181.0
CYP1A2 -6503.0
DPEP1 -6306.0
ACY1 -6052.5
MGST2 -3758.0
DPEP2 -3462.0
MGST1 654.0
MGST3 3678.0
CYP3A4 7085.5
CYP3A5 7085.5


SHC1 events in EGFR signaling

SHC1 events in EGFR signaling
1056
set SHC1 events in EGFR signaling
setSize 14
pANOVA 0.0231
s.dist 0.351
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491.0
EGFR 5410.0
KRAS 4959.0
EREG 3888.0
BTC 3507.0
GRB2 2365.0
EGF 1889.0
EPGN 1733.0
TGFA 1407.0
HRAS 209.0
AREG -267.5
SHC1 -1493.0
SOS1 -1772.0
HBEGF -1977.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491.0
EGFR 5410.0
KRAS 4959.0
EREG 3888.0
BTC 3507.0
GRB2 2365.0
EGF 1889.0
EPGN 1733.0
TGFA 1407.0
HRAS 209.0
AREG -267.5
SHC1 -1493.0
SOS1 -1772.0
HBEGF -1977.0


Termination of O-glycan biosynthesis

Termination of O-glycan biosynthesis
1251
set Termination of O-glycan biosynthesis
setSize 19
pANOVA 0.00985
s.dist -0.342
p.adjustANOVA 0.415



Top enriched genes

Top 20 genes
GeneID Gene Rank
MUC17 -8569
MUC2 -8374
ST3GAL3 -7923
ST6GALNAC2 -7897
MUC1 -7388
ST6GAL1 -6796
MUC6 -6495
MUC3A -6178
MUC4 -5586
ST3GAL1 -4911
ST3GAL2 -4322
MUC20 -3067
MUC19 -2534
ST6GALNAC4 -1430
MUC5B -1392
ST6GALNAC3 -1364
MUC13 -322
MUC15 4876
MUC16 6597

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MUC17 -8569
MUC2 -8374
ST3GAL3 -7923
ST6GALNAC2 -7897
MUC1 -7388
ST6GAL1 -6796
MUC6 -6495
MUC3A -6178
MUC4 -5586
ST3GAL1 -4911
ST3GAL2 -4322
MUC20 -3067
MUC19 -2534
ST6GALNAC4 -1430
MUC5B -1392
ST6GALNAC3 -1364
MUC13 -322
MUC15 4876
MUC16 6597


PI3K events in ERBB2 signaling

PI3K events in ERBB2 signaling
801
set PI3K events in ERBB2 signaling
setSize 16
pANOVA 0.0199
s.dist 0.336
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
ERBB4 6841
EGFR 5410
NRG1 5376
NRG3 5354
GAB1 4240
EREG 3888
PIK3R1 3668
BTC 3507
GRB2 2365
EGF 1889
NRG4 755
NRG2 -1156
HBEGF -1977
PIK3CA -2203
ERBB3 -3610
ERBB2 -7283

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ERBB4 6841
EGFR 5410
NRG1 5376
NRG3 5354
GAB1 4240
EREG 3888
PIK3R1 3668
BTC 3507
GRB2 2365
EGF 1889
NRG4 755
NRG2 -1156
HBEGF -1977
PIK3CA -2203
ERBB3 -3610
ERBB2 -7283


Activation of RAC1

Activation of RAC1
48
set Activation of RAC1
setSize 12
pANOVA 0.0443
s.dist 0.335
p.adjustANOVA 0.501



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLIT2 6943
PAK3 6663
NCK1 6344
NCK2 4317
ROBO1 4250
PAK1 3151
RAC1 2318
PAK6 1017
SOS2 -1075
SOS1 -1772
PAK2 -5918
PAK4 -6018

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLIT2 6943
PAK3 6663
NCK1 6344
NCK2 4317
ROBO1 4250
PAK1 3151
RAC1 2318
PAK6 1017
SOS2 -1075
SOS1 -1772
PAK2 -5918
PAK4 -6018


Removal of the Flap Intermediate from the C-strand

Removal of the Flap Intermediate from the C-strand
1018
set Removal of the Flap Intermediate from the C-strand
setSize 12
pANOVA 0.0448
s.dist -0.335
p.adjustANOVA 0.501



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD1 -9075
DNA2 -8862
POLD2 -8726
RPA2 -8622
TERF2 -8116
TINF2 -5492
PCNA -5055
RPA1 -1771
POLD3 1469
POT1 2166
TERF1 2795
WRN 3858

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD1 -9075
DNA2 -8862
POLD2 -8726
RPA2 -8622
TERF2 -8116
TINF2 -5492
PCNA -5055
RPA1 -1771
POLD3 1469
POT1 2166
TERF1 2795
WRN 3858


Gluconeogenesis

Gluconeogenesis
467
set Gluconeogenesis
setSize 29
pANOVA 0.00187
s.dist -0.334
p.adjustANOVA 0.163



Top enriched genes

Top 20 genes
GeneID Gene Rank
GPI -9169
SLC25A10 -8904
ENO2 -8859
GOT1 -8224
ALDOA -8201
PCK1 -7630
ALDOC -7395
ENO1 -6673
G6PC -6411
PGAM2 -5773
SLC25A1 -5700
FBP2 -4989
ENO3 -4810
FBP1 -4764
SLC25A11 -4483
GOT2 -4194
SLC37A2 -3786
GAPDHS -3331
SLC25A12 -3201
G6PC2 -3111

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPI -9169
SLC25A10 -8904
ENO2 -8859
GOT1 -8224
ALDOA -8201
PCK1 -7630
ALDOC -7395
ENO1 -6673
G6PC -6411
PGAM2 -5773
SLC25A1 -5700
FBP2 -4989
ENO3 -4810
FBP1 -4764
SLC25A11 -4483
GOT2 -4194
SLC37A2 -3786
GAPDHS -3331
SLC25A12 -3201
G6PC2 -3111
PCK2 -2821
SLC37A1 -1624
G6PC3 -1510
MDH1 -739
PGK2 668
SLC25A13 1567
PC 3059
ALDOB 5326
PGK1 6185


Processive synthesis on the lagging strand

Processive synthesis on the lagging strand
882
set Processive synthesis on the lagging strand
setSize 12
pANOVA 0.0469
s.dist -0.331
p.adjustANOVA 0.501



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD1 -9075
DNA2 -8862
POLD2 -8726
RPA2 -8622
PRIM1 -7779
POLA2 -5833
PCNA -5055
RPA1 -1771
PRIM2 -50
POLD3 1469
LIG1 4144
POLA1 5038

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD1 -9075
DNA2 -8862
POLD2 -8726
RPA2 -8622
PRIM1 -7779
POLA2 -5833
PCNA -5055
RPA1 -1771
PRIM2 -50
POLD3 1469
LIG1 4144
POLA1 5038


XBP1(S) activates chaperone genes

XBP1(S) activates chaperone genes
1355
set XBP1(S) activates chaperone genes
setSize 42
pANOVA 0.000305
s.dist -0.322
p.adjustANOVA 0.0354



Top enriched genes

Top 20 genes
GeneID Gene Rank
CUL7 -9176
ZBTB17 -9080
DCTN1 -9067
LMNA -9031
CXXC1 -8842
EXTL1 -8708
TLN1 -8595
HYOU1 -8438
TPP1 -7932
PPP2R5B -7445
SRPRB -7255
YIF1A -6894
WFS1 -6026
KDELR3 -5611
ARFGAP1 -5054
DNAJB11 -4718
SEC31A -4705
KLHDC3 -4472
EXTL3 -4351
ADD1 -3969

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CUL7 -9176.0
ZBTB17 -9080.0
DCTN1 -9067.0
LMNA -9031.0
CXXC1 -8842.0
EXTL1 -8708.0
TLN1 -8595.0
HYOU1 -8438.0
TPP1 -7932.0
PPP2R5B -7445.0
SRPRB -7255.0
YIF1A -6894.0
WFS1 -6026.0
KDELR3 -5611.0
ARFGAP1 -5054.0
DNAJB11 -4718.0
SEC31A -4705.0
KLHDC3 -4472.0
EXTL3 -4351.0
ADD1 -3969.0
PDIA6 -3493.0
CTDSP2 -3420.0
SYVN1 -3296.0
ATP6V0D1 -2912.0
DDX11 -2892.0
FKBP14 -2809.0
XBP1 -2549.0
GSK3A -1702.5
SULT1A3 -1527.5
PDIA5 -1504.0
SHC1 -1493.0
EXTL2 -1255.0
HDGF -713.0
GFPT1 -342.0
SRPR -302.0
DNAJC3 -203.0
PREB -53.0
C19orf10 1373.0
TSPYL2 1418.0
WIPI1 1605.0
SSR1 4780.0
EDEM1 6137.0


JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
595
set JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
setSize 16
pANOVA 0.0264
s.dist 0.321
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK8 6717
TAB2 6463
MAPK10 5903
MAP3K7 5044
MAP2K4 4935
TAB3 4017
TRAF6 3268
IRAK1 2480
NOD1 2465
IKBKG 1899
MAPK9 1597
UBE2N -257
TAB1 -2561
NOD2 -2707
IRAK2 -6655
MAP2K7 -7581

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK8 6717
TAB2 6463
MAPK10 5903
MAP3K7 5044
MAP2K4 4935
TAB3 4017
TRAF6 3268
IRAK1 2480
NOD1 2465
IKBKG 1899
MAPK9 1597
UBE2N -257
TAB1 -2561
NOD2 -2707
IRAK2 -6655
MAP2K7 -7581


Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
212
set Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
setSize 16
pANOVA 0.0269
s.dist 0.319
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
UBA52 1870
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
UBA52 1870
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528


Signaling by Ligand-Responsive EGFR Variants in Cancer

Signaling by Ligand-Responsive EGFR Variants in Cancer
1128
set Signaling by Ligand-Responsive EGFR Variants in Cancer
setSize 16
pANOVA 0.0269
s.dist 0.319
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
UBA52 1870
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
UBA52 1870
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528


TRAF6-mediated induction of TAK1 complex within TLR4 complex

TRAF6-mediated induction of TAK1 complex within TLR4 complex
1241
set TRAF6-mediated induction of TAK1 complex within TLR4 complex
setSize 13
pANOVA 0.0467
s.dist 0.319
p.adjustANOVA 0.501



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAB2 6463.0
TLR4 5985.0
MAP3K7 5044.0
LY96 4026.0
TAB3 4017.0
TRAF6 3268.0
TICAM2 3184.5
UBA52 1870.0
TICAM1 675.0
CD14 227.0
TAB1 -2561.0
SARM1 -5406.0
IRAK2 -6655.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAB2 6463.0
TLR4 5985.0
MAP3K7 5044.0
LY96 4026.0
TAB3 4017.0
TRAF6 3268.0
TICAM2 3184.5
UBA52 1870.0
TICAM1 675.0
CD14 227.0
TAB1 -2561.0
SARM1 -5406.0
IRAK2 -6655.0


Receptor-type tyrosine-protein phosphatases

Receptor-type tyrosine-protein phosphatases
956
set Receptor-type tyrosine-protein phosphatases
setSize 19
pANOVA 0.0162
s.dist 0.319
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTPRD 6719
IL1RAP 6424
IL1RAPL1 6410
SLITRK5 6215
SLITRK4 6169
IL1RAPL2 5902
SLITRK1 5835
SLITRK6 5719
SLITRK3 4792
SLITRK2 3617
NTRK3 2619
PPFIA1 914
PPFIBP2 -793
LRRC4B -2330
PPFIBP1 -2499
PTPRS -2990
PPFIA3 -6467
PTPRF -8218
PPFIA4 -8636

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTPRD 6719
IL1RAP 6424
IL1RAPL1 6410
SLITRK5 6215
SLITRK4 6169
IL1RAPL2 5902
SLITRK1 5835
SLITRK6 5719
SLITRK3 4792
SLITRK2 3617
NTRK3 2619
PPFIA1 914
PPFIBP2 -793
LRRC4B -2330
PPFIBP1 -2499
PTPRS -2990
PPFIA3 -6467
PTPRF -8218
PPFIA4 -8636


Polymerase switching on the C-strand of the telomere

Polymerase switching on the C-strand of the telomere
856
set Polymerase switching on the C-strand of the telomere
setSize 21
pANOVA 0.0117
s.dist -0.318
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHTF18 -9097
POLD1 -9075
POLD2 -8726
TERF2 -8116
PRIM1 -7779
RFC5 -7623
CTC1 -7350
TEN1 -6308
POLA2 -5833
TINF2 -5492
PCNA -5055
RFC3 -4339
RFC2 -2032
DSCC1 -1557
RFC1 -726
PRIM2 -50
RFC4 1109
POLD3 1469
POT1 2166
TERF1 2795

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHTF18 -9097
POLD1 -9075
POLD2 -8726
TERF2 -8116
PRIM1 -7779
RFC5 -7623
CTC1 -7350
TEN1 -6308
POLA2 -5833
TINF2 -5492
PCNA -5055
RFC3 -4339
RFC2 -2032
DSCC1 -1557
RFC1 -726
PRIM2 -50
RFC4 1109
POLD3 1469
POT1 2166
TERF1 2795
POLA1 5038


Constitutive Signaling by EGFRvIII

Constitutive Signaling by EGFRvIII
211
set Constitutive Signaling by EGFRvIII
setSize 15
pANOVA 0.0336
s.dist 0.317
p.adjustANOVA 0.463



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528


Signaling by EGFRvIII in Cancer

Signaling by EGFRvIII in Cancer
1100
set Signaling by EGFRvIII in Cancer
setSize 15
pANOVA 0.0336
s.dist 0.317
p.adjustANOVA 0.463



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491
EGFR 5410
KRAS 4959
GAB1 4240
PIK3R1 3668
CBL 2832
PLCG1 2753
GRB2 2365
EGF 1889
CDC37 1195
HRAS 209
SHC1 -1493
SOS1 -1772
PIK3CA -2203
HSP90AA1 -6528


Signaling by EGFR in Cancer

Signaling by EGFR in Cancer
1099
set Signaling by EGFR in Cancer
setSize 22
pANOVA 0.0108
s.dist 0.314
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
NRAS 5491.0
EGFR 5410.0
KRAS 4959.0
GAB1 4240.0
EREG 3888.0
PIK3R1 3668.0
BTC 3507.0
CBL 2832.0
PLCG1 2753.0
GRB2 2365.0
EGF 1889.0
UBA52 1870.0
EPGN 1733.0
TGFA 1407.0
CDC37 1195.0
HRAS 209.0
AREG -267.5
SHC1 -1493.0
SOS1 -1772.0
HBEGF -1977.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS 5491.0
EGFR 5410.0
KRAS 4959.0
GAB1 4240.0
EREG 3888.0
PIK3R1 3668.0
BTC 3507.0
CBL 2832.0
PLCG1 2753.0
GRB2 2365.0
EGF 1889.0
UBA52 1870.0
EPGN 1733.0
TGFA 1407.0
CDC37 1195.0
HRAS 209.0
AREG -267.5
SHC1 -1493.0
SOS1 -1772.0
HBEGF -1977.0
PIK3CA -2203.0
HSP90AA1 -6528.0


TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
1234
set TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
setSize 17
pANOVA 0.0253
s.dist -0.313
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRMT1 -8681.0
TP53 -8478.0
BAX -7421.0
CARM1 -6875.0
AURKA -6481.0
TFDP1 -5656.5
PCNA -5055.0
SFN -4853.0
CDK1 -4276.0
CCNB1 -3071.0
RBL2 -2794.0
RBL1 -1786.0
ZNF385A -1134.0
E2F4 140.0
GADD45A 1016.0
EP300 1892.0
TFDP2 2089.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRMT1 -8681.0
TP53 -8478.0
BAX -7421.0
CARM1 -6875.0
AURKA -6481.0
TFDP1 -5656.5
PCNA -5055.0
SFN -4853.0
CDK1 -4276.0
CCNB1 -3071.0
RBL2 -2794.0
RBL1 -1786.0
ZNF385A -1134.0
E2F4 140.0
GADD45A 1016.0
EP300 1892.0
TFDP2 2089.0


CD209 (DC-SIGN) signaling

CD209 (DC-SIGN) signaling
126
set CD209 (DC-SIGN) signaling
setSize 19
pANOVA 0.0184
s.dist 0.312
p.adjustANOVA 0.421



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD209 6987.5
PAK3 6663.0
LYN 6366.0
NRAS 5491.0
KRAS 4959.0
RELB 4547.0
PAK1 3151.0
PRKACB 2922.0
RAF1 2301.0
EP300 1892.0
CREBBP 1152.0
FYN 958.0
PRKACA 303.0
HRAS 209.0
RPS6KA5 -1192.0
NFKB1 -3161.0
RELA -3856.0
ICAM2 -5342.0
PAK2 -5918.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD209 6987.5
PAK3 6663.0
LYN 6366.0
NRAS 5491.0
KRAS 4959.0
RELB 4547.0
PAK1 3151.0
PRKACB 2922.0
RAF1 2301.0
EP300 1892.0
CREBBP 1152.0
FYN 958.0
PRKACA 303.0
HRAS 209.0
RPS6KA5 -1192.0
NFKB1 -3161.0
RELA -3856.0
ICAM2 -5342.0
PAK2 -5918.0


Acyl chain remodelling of PI

Acyl chain remodelling of PI
60
set Acyl chain remodelling of PI
setSize 14
pANOVA 0.0433
s.dist -0.312
p.adjustANOVA 0.501



Top enriched genes

Top 20 genes
GeneID Gene Rank
PLA2G1B -8445
MBOAT7 -7777
PLA2G5 -7617
PLA2G2D -7131
PLA2G2F -6730
PLA2G2E -5483
PLBD1 -4974
PLA2R1 -4923
PLA2G12A -4250
PLA2G4D -2011
PLA2G4F -434
PLA2G4E 807
PLA2G4A 3973
PLA2G4C 4574

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLA2G1B -8445
MBOAT7 -7777
PLA2G5 -7617
PLA2G2D -7131
PLA2G2F -6730
PLA2G2E -5483
PLBD1 -4974
PLA2R1 -4923
PLA2G12A -4250
PLA2G4D -2011
PLA2G4F -434
PLA2G4E 807
PLA2G4A 3973
PLA2G4C 4574


Signaling by Leptin

Signaling by Leptin
1127
set Signaling by Leptin
setSize 10
pANOVA 0.0882
s.dist -0.311
p.adjustANOVA 0.623



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT3 -8890
STAT5A -7671
SOCS3 -6938
SH2B1 -5696
IRS1 -5128
LEP -5051
PTPN11 -2492
STAT5B -2146
LEPR 2395
JAK2 5647

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT3 -8890
STAT5A -7671
SOCS3 -6938
SH2B1 -5696
IRS1 -5128
LEP -5051
PTPN11 -2492
STAT5B -2146
LEPR 2395
JAK2 5647


Activated NTRK2 signals through FRS2 and FRS3

Activated NTRK2 signals through FRS2 and FRS3
32
set Activated NTRK2 signals through FRS2 and FRS3
setSize 10
pANOVA 0.0891
s.dist 0.31
p.adjustANOVA 0.623



Top enriched genes

Top 20 genes
GeneID Gene Rank
BDNF 6682
NRAS 5491
KRAS 4959
GRB2 2365
FRS2 752
HRAS 209
NTF4 -149
NTRK2 -1218
SOS1 -1772
PTPN11 -2492

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BDNF 6682
NRAS 5491
KRAS 4959
GRB2 2365
FRS2 752
HRAS 209
NTF4 -149
NTRK2 -1218
SOS1 -1772
PTPN11 -2492


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] fgsea_1.14.0                gplots_3.0.3               
##  [9] DESeq2_1.28.1               SummarizedExperiment_1.18.1
## [11] DelayedArray_0.14.0         matrixStats_0.56.0         
## [13] Biobase_2.48.0              GenomicRanges_1.40.0       
## [15] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [17] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [19] reshape2_1.4.4              forcats_0.5.0              
## [21] stringr_1.4.0               dplyr_1.0.0                
## [23] purrr_0.3.4                 readr_1.3.1                
## [25] tidyr_1.1.0                 tibble_3.0.1               
## [27] ggplot2_3.3.2               tidyverse_1.3.0            
## [29] locfit_1.5-9.4              statmod_1.4.34             
## [31] plyr_1.8.6                 
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] farver_2.0.3           bit64_0.9-7            AnnotationDbi_1.50.1  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.29            
## [16] jsonlite_1.7.0         broom_0.5.6            annotate_1.66.0       
## [19] dbplyr_1.4.4           shiny_1.5.0            compiler_4.0.2        
## [22] httr_1.4.1             backports_1.1.8        assertthat_0.2.1      
## [25] Matrix_1.2-18          fastmap_1.0.1          cli_2.0.2             
## [28] later_1.1.0.1          prettyunits_1.1.1      htmltools_0.5.0       
## [31] tools_4.0.2            gtable_0.3.0           glue_1.4.1            
## [34] GenomeInfoDbData_1.2.3 fastmatch_1.1-0        Rcpp_1.0.4.6          
## [37] cellranger_1.1.0       vctrs_0.3.1            gdata_2.18.0          
## [40] nlme_3.1-148           xfun_0.15              testthat_2.3.2        
## [43] rvest_0.3.5            mime_0.9               lifecycle_0.2.0       
## [46] XML_3.99-0.3           zlibbioc_1.34.0        MASS_7.3-51.6         
## [49] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [52] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [55] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [58] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [61] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [64] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [67] evaluate_0.14          lattice_0.20-41        labeling_0.3          
## [70] htmlwidgets_1.5.1      bit_1.1-15.2           tidyselect_1.1.0      
## [73] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [76] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [79] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [82] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [85] rmarkdown_2.3          progress_1.2.2         grid_4.0.2            
## [88] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [91] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [94] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report