date generated: 2020-07-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## 5S_rRNA  0.4023900
## A1BG     0.8276224
## A1CF    -0.1176536
## A2M     -1.9577707
## A3GALT2  0.6904985
## A4GALT  -0.6623122

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 13888
duplicated_genes_present 0
num_profile_genes_in_sets 7447
num_profile_genes_not_in_sets 6441

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1067
num_genesets_included 1333

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set setSize pANOVA s.dist p.adjustANOVA
TRAF6 mediated IRF7 activation 28 1.26e-06 0.529 0.00168
Condensation of Prophase Chromosomes 10 6.77e-03 0.495 0.63700
Regulation of IFNA signaling 23 1.21e-04 0.463 0.08080
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 9.08e-03 0.454 0.63700
alpha-linolenic acid (ALA) metabolism 11 9.08e-03 0.454 0.63700
Heme degradation 15 2.32e-03 0.454 0.36200
E2F mediated regulation of DNA replication 18 1.09e-03 0.445 0.29200
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 12 1.29e-02 0.415 0.74800
Regulation of signaling by NODAL 10 4.41e-02 -0.368 0.85100
Regulation of PTEN mRNA translation 11 3.48e-02 0.368 0.85100
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 3.16e-02 0.358 0.85100
Golgi Cisternae Pericentriolar Stack Reorganization 11 4.17e-02 0.355 0.85100
Tandem pore domain potassium channels 11 4.26e-02 0.353 0.85100
Scavenging of heme from plasma 10 5.39e-02 -0.352 0.85100
Metabolism of porphyrins 25 2.45e-03 0.350 0.36200
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 11 5.14e-02 0.339 0.85100
FOXO-mediated transcription of cell death genes 13 3.69e-02 0.334 0.85100
Citric acid cycle (TCA cycle) 15 2.72e-02 0.329 0.85100
Cyclin A/B1/B2 associated events during G2/M transition 13 4.04e-02 0.328 0.85100
Nucleotide-like (purinergic) receptors 11 6.13e-02 -0.326 0.85100
Phase 4 - resting membrane potential 17 2.01e-02 0.326 0.80800
Diseases associated with the TLR signaling cascade 18 1.89e-02 -0.320 0.80800
Diseases of Immune System 18 1.89e-02 -0.320 0.80800
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 16 2.82e-02 0.317 0.85100
Eicosanoid ligand-binding receptors 10 8.44e-02 -0.315 0.85100
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 13 5.13e-02 0.312 0.85100
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 13 5.13e-02 0.312 0.85100
TP53 Regulates Transcription of Death Receptors and Ligands 10 8.87e-02 0.311 0.85300
HS-GAG biosynthesis 22 1.24e-02 -0.308 0.74800
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 8.21e-02 -0.303 0.85100
Defective EXT2 causes exostoses 2 11 8.21e-02 -0.303 0.85100
Regulation of TP53 Activity through Methylation 11 8.23e-02 -0.303 0.85100
Diseases of DNA repair 10 1.09e-01 0.293 0.88500
The role of Nef in HIV-1 replication and disease pathogenesis 23 1.55e-02 0.291 0.76800
ER Quality Control Compartment (ERQC) 12 8.14e-02 -0.291 0.85100
Synthesis of PC 20 2.50e-02 0.290 0.85100
Defective B4GALT7 causes EDS, progeroid type 15 5.46e-02 -0.287 0.85100
Norepinephrine Neurotransmitter Release Cycle 12 8.78e-02 -0.285 0.85300
Smooth Muscle Contraction 29 8.28e-03 0.283 0.63700
Heme biosynthesis 12 9.16e-02 0.281 0.85300
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.24e-01 -0.281 0.88500
Interferon alpha/beta signaling 50 6.44e-04 0.279 0.22200
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 12 9.70e-02 0.277 0.86800
Activation of SMO 10 1.31e-01 -0.276 0.88500
Initiation of Nuclear Envelope (NE) Reformation 14 7.45e-02 0.275 0.85100
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 1.33e-01 -0.275 0.88500
Cleavage of the damaged purine 10 1.35e-01 0.273 0.88500
Depurination 10 1.35e-01 0.273 0.88500
Recognition and association of DNA glycosylase with site containing an affected purine 10 1.35e-01 0.273 0.88500
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 25 1.85e-02 0.272 0.80800


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
TRAF6 mediated IRF7 activation 28 1.26e-06 5.29e-01 0.00168
Condensation of Prophase Chromosomes 10 6.77e-03 4.95e-01 0.63700
Regulation of IFNA signaling 23 1.21e-04 4.63e-01 0.08080
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 9.08e-03 4.54e-01 0.63700
alpha-linolenic acid (ALA) metabolism 11 9.08e-03 4.54e-01 0.63700
Heme degradation 15 2.32e-03 4.54e-01 0.36200
E2F mediated regulation of DNA replication 18 1.09e-03 4.45e-01 0.29200
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 12 1.29e-02 4.15e-01 0.74800
Regulation of signaling by NODAL 10 4.41e-02 -3.68e-01 0.85100
Regulation of PTEN mRNA translation 11 3.48e-02 3.68e-01 0.85100
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 3.16e-02 3.58e-01 0.85100
Golgi Cisternae Pericentriolar Stack Reorganization 11 4.17e-02 3.55e-01 0.85100
Tandem pore domain potassium channels 11 4.26e-02 3.53e-01 0.85100
Scavenging of heme from plasma 10 5.39e-02 -3.52e-01 0.85100
Metabolism of porphyrins 25 2.45e-03 3.50e-01 0.36200
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 11 5.14e-02 3.39e-01 0.85100
FOXO-mediated transcription of cell death genes 13 3.69e-02 3.34e-01 0.85100
Citric acid cycle (TCA cycle) 15 2.72e-02 3.29e-01 0.85100
Cyclin A/B1/B2 associated events during G2/M transition 13 4.04e-02 3.28e-01 0.85100
Nucleotide-like (purinergic) receptors 11 6.13e-02 -3.26e-01 0.85100
Phase 4 - resting membrane potential 17 2.01e-02 3.26e-01 0.80800
Diseases associated with the TLR signaling cascade 18 1.89e-02 -3.20e-01 0.80800
Diseases of Immune System 18 1.89e-02 -3.20e-01 0.80800
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 16 2.82e-02 3.17e-01 0.85100
Eicosanoid ligand-binding receptors 10 8.44e-02 -3.15e-01 0.85100
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 13 5.13e-02 3.12e-01 0.85100
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 13 5.13e-02 3.12e-01 0.85100
TP53 Regulates Transcription of Death Receptors and Ligands 10 8.87e-02 3.11e-01 0.85300
HS-GAG biosynthesis 22 1.24e-02 -3.08e-01 0.74800
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 8.21e-02 -3.03e-01 0.85100
Defective EXT2 causes exostoses 2 11 8.21e-02 -3.03e-01 0.85100
Regulation of TP53 Activity through Methylation 11 8.23e-02 -3.03e-01 0.85100
Diseases of DNA repair 10 1.09e-01 2.93e-01 0.88500
The role of Nef in HIV-1 replication and disease pathogenesis 23 1.55e-02 2.91e-01 0.76800
ER Quality Control Compartment (ERQC) 12 8.14e-02 -2.91e-01 0.85100
Synthesis of PC 20 2.50e-02 2.90e-01 0.85100
Defective B4GALT7 causes EDS, progeroid type 15 5.46e-02 -2.87e-01 0.85100
Norepinephrine Neurotransmitter Release Cycle 12 8.78e-02 -2.85e-01 0.85300
Smooth Muscle Contraction 29 8.28e-03 2.83e-01 0.63700
Heme biosynthesis 12 9.16e-02 2.81e-01 0.85300
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.24e-01 -2.81e-01 0.88500
Interferon alpha/beta signaling 50 6.44e-04 2.79e-01 0.22200
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 12 9.70e-02 2.77e-01 0.86800
Activation of SMO 10 1.31e-01 -2.76e-01 0.88500
Initiation of Nuclear Envelope (NE) Reformation 14 7.45e-02 2.75e-01 0.85100
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 1.33e-01 -2.75e-01 0.88500
Cleavage of the damaged purine 10 1.35e-01 2.73e-01 0.88500
Depurination 10 1.35e-01 2.73e-01 0.88500
Recognition and association of DNA glycosylase with site containing an affected purine 10 1.35e-01 2.73e-01 0.88500
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 25 1.85e-02 2.72e-01 0.80800
Regulation of TLR by endogenous ligand 13 9.12e-02 -2.71e-01 0.85300
eNOS activation 10 1.39e-01 -2.70e-01 0.88500
Insulin receptor recycling 15 7.10e-02 2.69e-01 0.85100
mTORC1-mediated signalling 17 5.60e-02 2.68e-01 0.85100
Deadenylation of mRNA 17 5.94e-02 2.64e-01 0.85100
Phase 2 - plateau phase 20 4.22e-02 -2.62e-01 0.85100
Chondroitin sulfate biosynthesis 18 5.42e-02 2.62e-01 0.85100
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.36e-01 2.60e-01 0.88500
Receptor-type tyrosine-protein phosphatases 14 9.40e-02 -2.59e-01 0.85300
Myogenesis 27 2.12e-02 -2.56e-01 0.80800
Glutathione synthesis and recycling 11 1.42e-01 -2.56e-01 0.88500
Telomere Extension By Telomerase 16 7.66e-02 2.56e-01 0.85100
Transport of vitamins, nucleosides, and related molecules 36 8.93e-03 2.52e-01 0.63700
Elevation of cytosolic Ca2+ levels 11 1.57e-01 -2.46e-01 0.89700
Depolymerisation of the Nuclear Lamina 12 1.43e-01 2.44e-01 0.88500
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 11 1.63e-01 2.43e-01 0.89700
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 11 1.67e-01 -2.41e-01 0.89700
Defective B3GALT6 causes EDSP2 and SEMDJL1 14 1.19e-01 -2.41e-01 0.88500
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 12 1.50e-01 2.40e-01 0.88800
Defective GALNT12 causes colorectal cancer 1 (CRCS1) 11 1.71e-01 -2.39e-01 0.89700
Apoptotic execution phase 39 1.03e-02 2.37e-01 0.67900
Activated NOTCH1 Transmits Signal to the Nucleus 22 5.40e-02 -2.37e-01 0.85100
FCERI mediated MAPK activation 25 4.04e-02 2.37e-01 0.85100
Na+/Cl- dependent neurotransmitter transporters 14 1.29e-01 2.34e-01 0.88500
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 13 1.45e-01 -2.34e-01 0.88500
O-glycosylation of TSR domain-containing proteins 33 2.03e-02 -2.34e-01 0.80800
Pentose phosphate pathway 10 2.02e-01 -2.33e-01 0.89700
Chaperone Mediated Autophagy 16 1.06e-01 -2.33e-01 0.88500
NOTCH2 Activation and Transmission of Signal to the Nucleus 14 1.32e-01 -2.33e-01 0.88500
Transport of organic anions 11 1.83e-01 2.32e-01 0.89700
Apoptotic cleavage of cellular proteins 32 2.38e-02 2.31e-01 0.83500
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 11 1.86e-01 -2.30e-01 0.89700
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 10 2.09e-01 -2.30e-01 0.89700
Xenobiotics 22 6.28e-02 2.29e-01 0.85100
Hyaluronan metabolism 11 1.88e-01 -2.29e-01 0.89700
HDMs demethylate histones 15 1.25e-01 2.29e-01 0.88500
Glycogen storage diseases 11 1.94e-01 -2.26e-01 0.89700
Regulation of pyruvate dehydrogenase (PDH) complex 12 1.79e-01 -2.24e-01 0.89700
Endogenous sterols 23 6.27e-02 -2.24e-01 0.85100
Defective B3GALTL causes Peters-plus syndrome (PpS) 32 2.85e-02 -2.24e-01 0.85100
Heparan sulfate/heparin (HS-GAG) metabolism 40 1.55e-02 -2.21e-01 0.76800
RNA Polymerase I Transcription Termination 17 1.15e-01 -2.21e-01 0.88500
Syndecan interactions 16 1.27e-01 -2.20e-01 0.88500
Activation of AMPK downstream of NMDARs 10 2.29e-01 -2.20e-01 0.89700
Interleukin-35 Signalling 11 2.09e-01 2.19e-01 0.89700
Aspartate and asparagine metabolism 10 2.33e-01 -2.18e-01 0.89700
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 22 7.73e-02 2.18e-01 0.85100
Signaling by BMP 25 6.00e-02 -2.17e-01 0.85100
Diseases associated with O-glycosylation of proteins 53 6.32e-03 -2.17e-01 0.63700
Organic cation/anion/zwitterion transport 13 1.77e-01 2.16e-01 0.89700
TNFs bind their physiological receptors 20 9.43e-02 2.16e-01 0.85300
HS-GAG degradation 16 1.37e-01 -2.15e-01 0.88500
Activation of RAC1 10 2.41e-01 2.14e-01 0.89700
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 2.03e-01 2.12e-01 0.89700
Platelet Adhesion to exposed collagen 11 2.25e-01 2.11e-01 0.89700
Mismatch Repair 13 1.88e-01 2.11e-01 0.89700
HDR through Single Strand Annealing (SSA) 26 6.28e-02 -2.11e-01 0.85100
Role of phospholipids in phagocytosis 25 6.82e-02 -2.11e-01 0.85100
Beta defensins 19 1.16e-01 -2.08e-01 0.88500
Prolonged ERK activation events 12 2.13e-01 2.08e-01 0.89700
Aggrephagy 18 1.29e-01 -2.07e-01 0.88500
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 12 2.15e-01 -2.07e-01 0.89700
Ribosomal scanning and start codon recognition 21 1.02e-01 2.06e-01 0.87300
Translation initiation complex formation 21 1.02e-01 2.06e-01 0.87300
Mitochondrial calcium ion transport 17 1.41e-01 2.06e-01 0.88500
DDX58/IFIH1-mediated induction of interferon-alpha/beta 59 6.27e-03 2.06e-01 0.63700
Activation of BAD and translocation to mitochondria 14 1.86e-01 2.04e-01 0.89700
The canonical retinoid cycle in rods (twilight vision) 19 1.25e-01 -2.04e-01 0.88500
Meiotic synapsis 29 5.82e-02 2.03e-01 0.85100
Striated Muscle Contraction 32 4.69e-02 -2.03e-01 0.85100
Late endosomal microautophagy 22 1.01e-01 -2.02e-01 0.87300
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 19 1.29e-01 2.01e-01 0.88500
RHO GTPases activate PKNs 27 7.20e-02 2.00e-01 0.85100
A tetrasaccharide linker sequence is required for GAG synthesis 20 1.23e-01 -1.99e-01 0.88500
PCNA-Dependent Long Patch Base Excision Repair 15 1.84e-01 1.98e-01 0.89700
Mitotic Prophase 61 7.66e-03 1.98e-01 0.63700
TRAF3-dependent IRF activation pathway 14 2.02e-01 1.97e-01 0.89700
Diseases of programmed cell death 18 1.51e-01 1.96e-01 0.88800
RAS processing 13 2.25e-01 1.95e-01 0.89700
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 17 1.66e-01 1.94e-01 0.89700
Metalloprotease DUBs 16 1.80e-01 1.94e-01 0.89700
N-glycan antennae elongation in the medial/trans-Golgi 19 1.45e-01 -1.93e-01 0.88500
Regulation of gene expression in beta cells 14 2.11e-01 -1.93e-01 0.89700
NOTCH4 Intracellular Domain Regulates Transcription 18 1.57e-01 1.93e-01 0.89700
RHO GTPases Activate WASPs and WAVEs 30 6.81e-02 1.93e-01 0.85100
PI3K Cascade 38 4.02e-02 -1.92e-01 0.85100
Metabolic disorders of biological oxidation enzymes 29 7.32e-02 -1.92e-01 0.85100
Interleukin-12 family signaling 41 3.42e-02 1.91e-01 0.85100
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 13 2.33e-01 1.91e-01 0.89700
Nuclear Envelope (NE) Reassembly 56 1.38e-02 1.90e-01 0.76400
Synthesis of IP3 and IP4 in the cytosol 22 1.25e-01 1.89e-01 0.88500
Presynaptic phase of homologous DNA pairing and strand exchange 25 1.02e-01 -1.89e-01 0.87300
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 2.58e-01 1.89e-01 0.89700
GAB1 signalosome 14 2.23e-01 -1.88e-01 0.89700
Fertilization 19 1.58e-01 -1.87e-01 0.89700
Metabolism of steroid hormones 29 8.15e-02 -1.87e-01 0.85100
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 50 2.24e-02 1.87e-01 0.80800
Nonsense-Mediated Decay (NMD) 50 2.24e-02 1.87e-01 0.80800
CD28 dependent PI3K/Akt signaling 20 1.50e-01 -1.86e-01 0.88800
FCERI mediated Ca+2 mobilization 24 1.15e-01 1.86e-01 0.88500
Signalling to ERKs 30 7.91e-02 1.85e-01 0.85100
Pyruvate metabolism 23 1.25e-01 -1.85e-01 0.88500
Processing of Capped Intronless Pre-mRNA 17 1.88e-01 1.85e-01 0.89700
Signaling by NODAL 18 1.77e-01 -1.84e-01 0.89700
G1/S-Specific Transcription 24 1.19e-01 1.84e-01 0.88500
N-Glycan antennae elongation 12 2.71e-01 -1.84e-01 0.89800
Deactivation of the beta-catenin transactivating complex 28 9.28e-02 -1.84e-01 0.85300
Transcription of E2F targets under negative control by DREAM complex 16 2.04e-01 1.83e-01 0.89700
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 2.56e-01 -1.82e-01 0.89700
Triglyceride catabolism 18 1.82e-01 -1.82e-01 0.89700
Termination of O-glycan biosynthesis 17 1.95e-01 -1.82e-01 0.89700
Neurexins and neuroligins 50 2.65e-02 -1.82e-01 0.85100
Transferrin endocytosis and recycling 20 1.60e-01 1.81e-01 0.89700
RNA Polymerase I Transcription Initiation 30 8.67e-02 -1.81e-01 0.85300
Antimicrobial peptides 45 3.61e-02 -1.81e-01 0.85100
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 2.79e-01 1.81e-01 0.90400
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 10 3.23e-01 -1.81e-01 0.92900
Incretin synthesis, secretion, and inactivation 16 2.14e-01 -1.80e-01 0.89700
Cyclin D associated events in G1 32 7.90e-02 1.80e-01 0.85100
G1 Phase 32 7.90e-02 1.80e-01 0.85100
Selective autophagy 47 3.35e-02 -1.79e-01 0.85100
Fatty acyl-CoA biosynthesis 27 1.07e-01 1.79e-01 0.88500
Regulation of Complement cascade 38 5.65e-02 -1.79e-01 0.85100
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 19 1.79e-01 -1.78e-01 0.89700
PERK regulates gene expression 20 1.71e-01 1.77e-01 0.89700
Signal transduction by L1 15 2.36e-01 1.77e-01 0.89700
Biosynthesis of DHA-derived SPMs 14 2.52e-01 1.77e-01 0.89700
Interleukin-12 signaling 32 8.49e-02 1.76e-01 0.85100
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 13 2.74e-01 1.75e-01 0.89800
Diseases of hemostasis 13 2.74e-01 1.75e-01 0.89800
Defensins 20 1.76e-01 -1.75e-01 0.89700
Signalling to RAS 17 2.12e-01 1.75e-01 0.89700
Intrinsic Pathway of Fibrin Clot Formation 18 2.01e-01 1.74e-01 0.89700
Budding and maturation of HIV virion 17 2.16e-01 -1.73e-01 0.89700
Mitochondrial tRNA aminoacylation 12 2.99e-01 -1.73e-01 0.91700
Methylation 10 3.44e-01 -1.73e-01 0.92900
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 17 2.18e-01 1.73e-01 0.89700
Neurodegenerative Diseases 17 2.18e-01 1.73e-01 0.89700
MicroRNA (miRNA) biogenesis 13 2.82e-01 -1.73e-01 0.90400
Metabolism of nitric oxide: NOS3 activation and regulation 14 2.64e-01 -1.72e-01 0.89800
Constitutive Signaling by EGFRvIII 13 2.84e-01 1.72e-01 0.90400
Signaling by EGFRvIII in Cancer 13 2.84e-01 1.72e-01 0.90400
Resolution of D-loop Structures through Holliday Junction Intermediates 22 1.66e-01 -1.71e-01 0.89700
Defective B3GAT3 causes JDSSDHD 15 2.53e-01 -1.71e-01 0.89700
Arachidonic acid metabolism 46 4.64e-02 1.70e-01 0.85100
RNA Polymerase II Transcription Termination 46 4.65e-02 1.70e-01 0.85100
Mitochondrial protein import 45 4.91e-02 -1.70e-01 0.85100
HIV elongation arrest and recovery 15 2.56e-01 -1.69e-01 0.89700
Pausing and recovery of HIV elongation 15 2.56e-01 -1.69e-01 0.89700
Pausing and recovery of Tat-mediated HIV elongation 15 2.56e-01 -1.69e-01 0.89700
Tat-mediated HIV elongation arrest and recovery 15 2.56e-01 -1.69e-01 0.89700
Carnitine metabolism 11 3.31e-01 -1.69e-01 0.92900
Cell surface interactions at the vascular wall 114 1.89e-03 -1.69e-01 0.35900
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 3.34e-01 1.68e-01 0.92900
Activation of gene expression by SREBF (SREBP) 35 8.61e-02 1.68e-01 0.85300
Insulin processing 17 2.36e-01 1.66e-01 0.89700
Kinesins 34 9.47e-02 -1.66e-01 0.85300
Glucagon-type ligand receptors 25 1.53e-01 1.65e-01 0.89100
Homologous DNA Pairing and Strand Exchange 28 1.31e-01 -1.65e-01 0.88500
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 46 5.33e-02 -1.65e-01 0.85100
Constitutive Signaling by NOTCH1 HD Domain Mutants 11 3.45e-01 -1.65e-01 0.92900
Signaling by NOTCH1 HD Domain Mutants in Cancer 11 3.45e-01 -1.65e-01 0.92900
ATF4 activates genes in response to endoplasmic reticulum stress 17 2.40e-01 1.64e-01 0.89700
Protein-protein interactions at synapses 73 1.53e-02 -1.64e-01 0.76800
FGFR4 ligand binding and activation 11 3.46e-01 -1.64e-01 0.92900
Generation of second messenger molecules 23 1.75e-01 1.63e-01 0.89700
Basigin interactions 23 1.77e-01 -1.63e-01 0.89700
Lysine catabolism 11 3.54e-01 1.62e-01 0.93100
IGF1R signaling cascade 45 6.10e-02 -1.62e-01 0.85100
Translesion Synthesis by POLH 11 3.54e-01 1.61e-01 0.93100
Activation of Matrix Metalloproteinases 23 1.82e-01 -1.61e-01 0.89700
Plasma lipoprotein assembly 12 3.35e-01 -1.61e-01 0.92900
VEGFR2 mediated vascular permeability 25 1.66e-01 -1.60e-01 0.89700
Regulation of necroptotic cell death 12 3.37e-01 1.60e-01 0.92900
SUMOylation of DNA replication proteins 32 1.18e-01 1.60e-01 0.88500
Sealing of the nuclear envelope (NE) by ESCRT-III 24 1.76e-01 1.60e-01 0.89700
SARS-CoV-1 Infection 32 1.18e-01 1.60e-01 0.88500
mRNA 3'-end processing 40 8.38e-02 1.58e-01 0.85100
Negative epigenetic regulation of rRNA expression 29 1.42e-01 -1.58e-01 0.88500
p38MAPK events 12 3.46e-01 1.57e-01 0.92900
Pyrimidine catabolism 10 3.90e-01 1.57e-01 0.94500
DARPP-32 events 20 2.25e-01 1.57e-01 0.89700
Regulation of KIT signaling 11 3.69e-01 1.56e-01 0.94500
Gluconeogenesis 28 1.53e-01 -1.56e-01 0.89100
Formation of tubulin folding intermediates by CCT/TriC 19 2.40e-01 1.56e-01 0.89700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 25 1.79e-01 1.55e-01 0.89700
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 36 1.08e-01 1.55e-01 0.88500
Cell recruitment (pro-inflammatory response) 19 2.44e-01 -1.55e-01 0.89700
Purinergic signaling in leishmaniasis infection 19 2.44e-01 -1.55e-01 0.89700
IRS-mediated signalling 41 8.72e-02 -1.54e-01 0.85300
Passive transport by Aquaporins 12 3.54e-01 -1.54e-01 0.93100
Frs2-mediated activation 10 4.00e-01 1.54e-01 0.94500
Resolution of D-Loop Structures 23 2.02e-01 -1.54e-01 0.89700
Serotonin Neurotransmitter Release Cycle 11 3.79e-01 -1.53e-01 0.94500
ECM proteoglycans 47 6.97e-02 -1.53e-01 0.85100
Post-chaperonin tubulin folding pathway 20 2.37e-01 1.53e-01 0.89700
NOTCH2 intracellular domain regulates transcription 10 4.03e-01 1.53e-01 0.94500
Acyl chain remodelling of PS 16 2.91e-01 -1.53e-01 0.90700
tRNA Aminoacylation 17 2.77e-01 -1.52e-01 0.90000
Signaling by cytosolic FGFR1 fusion mutants 16 2.92e-01 1.52e-01 0.90700
RIPK1-mediated regulated necrosis 14 3.26e-01 1.52e-01 0.92900
Regulated Necrosis 14 3.26e-01 1.52e-01 0.92900
CD28 dependent Vav1 pathway 11 3.84e-01 1.52e-01 0.94500
Glyoxylate metabolism and glycine degradation 26 1.82e-01 -1.51e-01 0.89700
Transport of Mature Transcript to Cytoplasm 60 4.31e-02 1.51e-01 0.85100
Digestion and absorption 21 2.32e-01 -1.51e-01 0.89700
IRS-related events triggered by IGF1R 44 8.39e-02 -1.51e-01 0.85100
Processing of Intronless Pre-mRNAs 11 3.87e-01 1.51e-01 0.94500
Glycogen synthesis 11 3.89e-01 -1.50e-01 0.94500
PECAM1 interactions 10 4.12e-01 1.50e-01 0.94500
Formation of the cornified envelope 31 1.50e-01 -1.50e-01 0.88800
G0 and Early G1 22 2.26e-01 1.49e-01 0.89700
Assembly of collagen fibrils and other multimeric structures 45 8.37e-02 -1.49e-01 0.85100
Postmitotic nuclear pore complex (NPC) reformation 20 2.50e-01 1.49e-01 0.89700
Protein ubiquitination 38 1.14e-01 1.48e-01 0.88500
MAPK targets/ Nuclear events mediated by MAP kinases 26 1.91e-01 1.48e-01 0.89700
NoRC negatively regulates rRNA expression 26 1.93e-01 -1.48e-01 0.89700
L13a-mediated translational silencing of Ceruloplasmin expression 44 9.08e-02 1.47e-01 0.85300
Metabolism of non-coding RNA 34 1.37e-01 1.47e-01 0.88500
snRNP Assembly 34 1.37e-01 1.47e-01 0.88500
Effects of PIP2 hydrolysis 20 2.57e-01 -1.46e-01 0.89700
Eukaryotic Translation Elongation 37 1.25e-01 1.46e-01 0.88500
Signaling by ERBB2 ECD mutants 14 3.46e-01 1.45e-01 0.92900
KSRP (KHSRP) binds and destabilizes mRNA 13 3.64e-01 1.45e-01 0.94300
FGFRL1 modulation of FGFR1 signaling 12 3.84e-01 1.45e-01 0.94500
Role of LAT2/NTAL/LAB on calcium mobilization 13 3.67e-01 1.45e-01 0.94500
Gastrin-CREB signalling pathway via PKC and MAPK 16 3.18e-01 1.44e-01 0.92900
Non-integrin membrane-ECM interactions 35 1.40e-01 -1.44e-01 0.88500
Oncogene Induced Senescence 25 2.14e-01 1.44e-01 0.89700
Peptide chain elongation 34 1.48e-01 1.44e-01 0.88800
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 6.92e-02 1.43e-01 0.85100
mRNA decay by 3' to 5' exoribonuclease 10 4.34e-01 1.43e-01 0.94500
TRP channels 20 2.70e-01 -1.43e-01 0.89800
Spry regulation of FGF signaling 11 4.13e-01 1.43e-01 0.94500
Sema3A PAK dependent Axon repulsion 12 3.95e-01 1.42e-01 0.94500
SUMOylation of DNA damage response and repair proteins 50 8.34e-02 1.42e-01 0.85100
CD209 (DC-SIGN) signaling 18 3.00e-01 1.41e-01 0.91700
Keratan sulfate biosynthesis 21 2.63e-01 1.41e-01 0.89800
Complement cascade 48 9.11e-02 -1.41e-01 0.85300
Selenocysteine synthesis 36 1.44e-01 1.41e-01 0.88500
NCAM1 interactions 30 1.84e-01 -1.40e-01 0.89700
Biosynthesis of specialized proresolving mediators (SPMs) 16 3.34e-01 1.40e-01 0.92900
GTP hydrolysis and joining of the 60S ribosomal subunit 45 1.06e-01 1.39e-01 0.88500
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 24 2.41e-01 1.38e-01 0.89700
G alpha (12/13) signalling events 65 5.50e-02 -1.38e-01 0.85100
Regulation of signaling by CBL 15 3.56e-01 1.38e-01 0.93100
Signaling by RAF1 mutants 31 1.87e-01 1.37e-01 0.89700
Interferon Signaling 133 6.48e-03 1.37e-01 0.63700
RORA activates gene expression 16 3.44e-01 1.37e-01 0.92900
TGF-beta receptor signaling activates SMADs 19 3.03e-01 -1.37e-01 0.91800
NEP/NS2 Interacts with the Cellular Export Machinery 22 2.68e-01 1.37e-01 0.89800
Synthesis of very long-chain fatty acyl-CoAs 19 3.03e-01 1.36e-01 0.91800
Regulation of TP53 Activity through Association with Co-factors 12 4.16e-01 1.36e-01 0.94500
Iron uptake and transport 41 1.33e-01 1.36e-01 0.88500
SUMOylation of SUMOylation proteins 22 2.72e-01 1.35e-01 0.89800
Base Excision Repair 37 1.55e-01 1.35e-01 0.89700
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 11 4.40e-01 1.34e-01 0.94500
Meiosis 46 1.16e-01 1.34e-01 0.88500
ERKs are inactivated 11 4.43e-01 1.34e-01 0.94500
Sema4D in semaphorin signaling 19 3.16e-01 -1.33e-01 0.92900
Rev-mediated nuclear export of HIV RNA 24 2.60e-01 1.33e-01 0.89800
NGF-stimulated transcription 32 1.94e-01 1.33e-01 0.89700
RUNX2 regulates osteoblast differentiation 18 3.29e-01 1.33e-01 0.92900
Positive epigenetic regulation of rRNA expression 32 1.96e-01 -1.32e-01 0.89700
O-linked glycosylation 85 3.59e-02 -1.32e-01 0.85100
Metabolism of amine-derived hormones 15 3.77e-01 -1.32e-01 0.94500
Prefoldin mediated transfer of substrate to CCT/TriC 21 2.96e-01 1.32e-01 0.91600
Binding and Uptake of Ligands by Scavenger Receptors 33 1.90e-01 -1.32e-01 0.89700
Vpr-mediated nuclear import of PICs 23 2.76e-01 1.31e-01 0.89900
Transport of bile salts and organic acids, metal ions and amine compounds 65 6.77e-02 1.31e-01 0.85100
Class I peroxisomal membrane protein import 11 4.52e-01 -1.31e-01 0.94500
RNA Polymerase I Promoter Escape 17 3.50e-01 -1.31e-01 0.93100
Formation of the ternary complex, and subsequently, the 43S complex 18 3.37e-01 1.31e-01 0.92900
Recycling pathway of L1 24 2.68e-01 1.31e-01 0.89800
Transcriptional Regulation by E2F6 27 2.40e-01 1.31e-01 0.89700
mRNA decay by 5' to 3' exoribonuclease 12 4.33e-01 -1.31e-01 0.94500
Regulation of PLK1 Activity at G2/M Transition 63 7.40e-02 1.30e-01 0.85100
Caspase-mediated cleavage of cytoskeletal proteins 10 4.76e-01 1.30e-01 0.94500
Extracellular matrix organization 234 6.65e-04 -1.30e-01 0.22200
Transport of Mature mRNA Derived from an Intronless Transcript 28 2.37e-01 1.29e-01 0.89700
Synaptic adhesion-like molecules 18 3.45e-01 -1.29e-01 0.92900
Interleukin-7 signaling 14 4.07e-01 -1.28e-01 0.94500
MHC class II antigen presentation 86 4.08e-02 -1.28e-01 0.85100
Antigen processing-Cross presentation 68 6.95e-02 -1.27e-01 0.85100
SARS-CoV Infections 58 9.40e-02 1.27e-01 0.85300
Class C/3 (Metabotropic glutamate/pheromone receptors) 18 3.51e-01 1.27e-01 0.93100
Purine salvage 11 4.66e-01 1.27e-01 0.94500
Collagen formation 70 6.76e-02 -1.26e-01 0.85100
Nuclear signaling by ERBB4 25 2.75e-01 -1.26e-01 0.89800
PKA-mediated phosphorylation of CREB 16 3.84e-01 1.26e-01 0.94500
Regulation of RUNX1 Expression and Activity 14 4.16e-01 1.26e-01 0.94500
PI-3K cascade:FGFR4 17 3.70e-01 -1.25e-01 0.94500
Lewis blood group biosynthesis 10 4.92e-01 -1.25e-01 0.94500
Class B/2 (Secretin family receptors) 72 6.65e-02 1.25e-01 0.85100
SUMOylation of intracellular receptors 26 2.69e-01 1.25e-01 0.89800
Transport of Mature mRNAs Derived from Intronless Transcripts 29 2.44e-01 1.25e-01 0.89700
Translation of structural proteins 19 3.46e-01 1.25e-01 0.92900
Sphingolipid de novo biosynthesis 32 2.22e-01 1.25e-01 0.89700
Transcriptional regulation of white adipocyte differentiation 67 7.82e-02 1.25e-01 0.85100
COPI-dependent Golgi-to-ER retrograde traffic 62 9.07e-02 -1.24e-01 0.85300
Antiviral mechanism by IFN-stimulated genes 55 1.12e-01 1.24e-01 0.88500
Phospholipase C-mediated cascade; FGFR4 12 4.57e-01 -1.24e-01 0.94500
Nuclear Events (kinase and transcription factor activation) 51 1.26e-01 1.24e-01 0.88500
ISG15 antiviral mechanism 49 1.37e-01 1.23e-01 0.88500
Regulation of innate immune responses to cytosolic DNA 11 4.82e-01 -1.22e-01 0.94500
MAP2K and MAPK activation 29 2.54e-01 1.22e-01 0.89700
Regulation of TP53 Activity through Phosphorylation 67 8.43e-02 -1.22e-01 0.85100
Retinoid metabolism and transport 30 2.50e-01 -1.21e-01 0.89700
MECP2 regulates neuronal receptors and channels 14 4.31e-01 -1.21e-01 0.94500
Glutamate and glutamine metabolism 13 4.48e-01 -1.21e-01 0.94500
Plasma lipoprotein remodeling 23 3.14e-01 -1.21e-01 0.92900
EPHA-mediated growth cone collapse 12 4.67e-01 1.21e-01 0.94500
XBP1(S) activates chaperone genes 38 1.97e-01 -1.21e-01 0.89700
Synthesis of glycosylphosphatidylinositol (GPI) 12 4.68e-01 1.21e-01 0.94500
Interactions of Rev with host cellular proteins 25 2.96e-01 1.21e-01 0.91600
Regulation of TP53 Activity through Acetylation 23 3.16e-01 -1.21e-01 0.92900
Platelet sensitization by LDL 15 4.20e-01 -1.20e-01 0.94500
Amino acids regulate mTORC1 36 2.12e-01 1.20e-01 0.89700
Response of Mtb to phagocytosis 18 3.78e-01 1.20e-01 0.94500
Signaling by PDGFRA extracellular domain mutants 11 4.91e-01 1.20e-01 0.94500
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 11 4.91e-01 1.20e-01 0.94500
Signaling by WNT in cancer 27 2.81e-01 -1.20e-01 0.90400
Signaling by Activin 12 4.72e-01 1.20e-01 0.94500
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 4.93e-01 1.19e-01 0.94500
RNA Polymerase I Promoter Clearance 33 2.35e-01 -1.19e-01 0.89700
Transport of Ribonucleoproteins into the Host Nucleus 22 3.33e-01 1.19e-01 0.92900
Surfactant metabolism 20 3.59e-01 -1.18e-01 0.93400
DNA Damage/Telomere Stress Induced Senescence 21 3.48e-01 1.18e-01 0.93100
CLEC7A (Dectin-1) induces NFAT activation 10 5.18e-01 1.18e-01 0.94500
Circadian Clock 56 1.27e-01 1.18e-01 0.88500
Glutamate Neurotransmitter Release Cycle 19 3.75e-01 -1.18e-01 0.94500
CASP8 activity is inhibited 10 5.21e-01 1.17e-01 0.94500
Dimerization of procaspase-8 10 5.21e-01 1.17e-01 0.94500
Regulation by c-FLIP 10 5.21e-01 1.17e-01 0.94500
Diseases associated with visual transduction 11 5.05e-01 1.16e-01 0.94500
Diseases of the neuronal system 11 5.05e-01 1.16e-01 0.94500
Retinoid cycle disease events 11 5.05e-01 1.16e-01 0.94500
Acetylcholine Neurotransmitter Release Cycle 11 5.05e-01 -1.16e-01 0.94500
Diseases of glycosylation 114 3.31e-02 -1.16e-01 0.85100
Extension of Telomeres 36 2.30e-01 1.16e-01 0.89700
Sulfur amino acid metabolism 21 3.59e-01 -1.16e-01 0.93400
Transcriptional regulation of granulopoiesis 29 2.82e-01 1.15e-01 0.90400
G1/S Transition 94 5.41e-02 1.15e-01 0.85100
YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 4.90e-01 1.15e-01 0.94500
RHO GTPases activate CIT 16 4.26e-01 1.15e-01 0.94500
Export of Viral Ribonucleoproteins from Nucleus 23 3.42e-01 1.14e-01 0.92900
Resolution of Sister Chromatid Cohesion 78 8.14e-02 1.14e-01 0.85100
SRP-dependent cotranslational protein targeting to membrane 49 1.67e-01 1.14e-01 0.89700
RAF-independent MAPK1/3 activation 18 4.03e-01 1.14e-01 0.94500
PRC2 methylates histones and DNA 11 5.16e-01 1.13e-01 0.94500
Mitotic G2-G2/M phases 131 2.59e-02 1.13e-01 0.85100
Signaling by FGFR1 in disease 32 2.69e-01 1.13e-01 0.89800
Formation of a pool of free 40S subunits 40 2.18e-01 1.13e-01 0.89700
FGFR2c ligand binding and activation 10 5.38e-01 -1.13e-01 0.94500
Gap-filling DNA repair synthesis and ligation in TC-NER 43 2.02e-01 1.12e-01 0.89700
SUMOylation of ubiquitinylation proteins 26 3.24e-01 1.12e-01 0.92900
Translocation of ZAP-70 to Immunological synapse 12 5.03e-01 1.12e-01 0.94500
Deadenylation-dependent mRNA decay 39 2.27e-01 1.12e-01 0.89700
AURKA Activation by TPX2 57 1.45e-01 1.12e-01 0.88500
Golgi-to-ER retrograde transport 89 6.98e-02 -1.11e-01 0.85100
Intraflagellar transport 36 2.49e-01 -1.11e-01 0.89700
MET activates PTK2 signaling 16 4.43e-01 -1.11e-01 0.94500
Sialic acid metabolism 27 3.19e-01 -1.11e-01 0.92900
Tight junction interactions 26 3.29e-01 -1.11e-01 0.92900
Calnexin/calreticulin cycle 15 4.59e-01 -1.10e-01 0.94500
WNT5A-dependent internalization of FZD4 12 5.09e-01 1.10e-01 0.94500
DNA Damage Bypass 32 2.82e-01 1.10e-01 0.90400
Adherens junctions interactions 19 4.07e-01 -1.10e-01 0.94500
Cap-dependent Translation Initiation 51 1.75e-01 1.10e-01 0.89700
Eukaryotic Translation Initiation 51 1.75e-01 1.10e-01 0.89700
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 4.20e-01 -1.10e-01 0.94500
Downstream signal transduction 26 3.34e-01 1.10e-01 0.92900
Signaling by Erythropoietin 21 3.85e-01 1.09e-01 0.94500
NOTCH3 Activation and Transmission of Signal to the Nucleus 19 4.10e-01 -1.09e-01 0.94500
Synthesis of PIPs at the plasma membrane 48 1.91e-01 1.09e-01 0.89700
Regulation of MECP2 expression and activity 23 3.66e-01 1.09e-01 0.94500
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 5.14e-01 1.09e-01 0.94500
Cargo concentration in the ER 22 3.77e-01 -1.09e-01 0.94500
Free fatty acids regulate insulin secretion 11 5.32e-01 -1.09e-01 0.94500
Deubiquitination 186 1.07e-02 1.09e-01 0.67900
ERK/MAPK targets 19 4.13e-01 1.08e-01 0.94500
Regulation of expression of SLITs and ROBOs 90 7.64e-02 1.08e-01 0.85100
The NLRP3 inflammasome 11 5.35e-01 -1.08e-01 0.94500
Glucagon signaling in metabolic regulation 25 3.51e-01 1.08e-01 0.93100
Signaling by PDGFR in disease 18 4.29e-01 1.08e-01 0.94500
Prolactin receptor signaling 13 5.02e-01 1.07e-01 0.94500
Golgi Associated Vesicle Biogenesis 40 2.40e-01 1.07e-01 0.89700
Regulation of RUNX3 expression and activity 38 2.56e-01 -1.07e-01 0.89700
p75NTR signals via NF-kB 10 5.61e-01 -1.06e-01 0.94500
Nephrin family interactions 19 4.24e-01 1.06e-01 0.94500
G2/M Transition 129 3.82e-02 1.06e-01 0.85100
Assembly of active LPL and LIPC lipase complexes 16 4.64e-01 -1.06e-01 0.94500
Amyloid fiber formation 35 2.80e-01 1.06e-01 0.90400
Viral mRNA Translation 34 2.87e-01 1.06e-01 0.90700
Activation of Ca-permeable Kainate Receptor 10 5.63e-01 -1.06e-01 0.94500
Ionotropic activity of kainate receptors 10 5.63e-01 -1.06e-01 0.94500
Integrin cell surface interactions 56 1.75e-01 -1.05e-01 0.89700
Activation of HOX genes during differentiation 41 2.46e-01 1.05e-01 0.89700
Activation of anterior HOX genes in hindbrain development during early embryogenesis 41 2.46e-01 1.05e-01 0.89700
Transcriptional activation of mitochondrial biogenesis 45 2.25e-01 1.05e-01 0.89700
Degradation of the extracellular matrix 84 9.78e-02 -1.05e-01 0.86900
O-linked glycosylation of mucins 48 2.10e-01 -1.05e-01 0.89700
Phase I - Functionalization of compounds 84 9.85e-02 1.04e-01 0.86900
Other interleukin signaling 17 4.57e-01 -1.04e-01 0.94500
Platelet Aggregation (Plug Formation) 33 3.00e-01 1.04e-01 0.91700
Synthesis of PA 29 3.32e-01 -1.04e-01 0.92900
Signaling by Non-Receptor Tyrosine Kinases 41 2.50e-01 1.04e-01 0.89700
Signaling by PTK6 41 2.50e-01 1.04e-01 0.89700
Other semaphorin interactions 18 4.46e-01 1.04e-01 0.94500
Blood group systems biosynthesis 12 5.35e-01 -1.04e-01 0.94500
Processing of SMDT1 11 5.52e-01 1.04e-01 0.94500
Cholesterol biosynthesis 16 4.75e-01 -1.03e-01 0.94500
Transcriptional regulation by small RNAs 29 3.37e-01 1.03e-01 0.92900
Inositol phosphate metabolism 39 2.66e-01 1.03e-01 0.89800
Signaling by NTRK1 (TRKA) 99 7.71e-02 1.03e-01 0.85100
Ion homeostasis 41 2.56e-01 1.03e-01 0.89700
Response of EIF2AK4 (GCN2) to amino acid deficiency 39 2.69e-01 1.02e-01 0.89800
Sema4D induced cell migration and growth-cone collapse 16 4.80e-01 -1.02e-01 0.94500
Common Pathway of Fibrin Clot Formation 18 4.54e-01 -1.02e-01 0.94500
Inflammasomes 16 4.81e-01 1.02e-01 0.94500
Interleukin-27 signaling 10 5.78e-01 1.02e-01 0.94500
RNA Polymerase I Transcription 34 3.05e-01 -1.02e-01 0.92300
Association of TriC/CCT with target proteins during biosynthesis 30 3.37e-01 1.01e-01 0.92900
SUMOylation of RNA binding proteins 35 3.00e-01 1.01e-01 0.91700
Nuclear Envelope Breakdown 37 2.87e-01 1.01e-01 0.90700
Signaling by TGF-beta Receptor Complex 50 2.17e-01 -1.01e-01 0.89700
Cell-cell junction organization 47 2.31e-01 -1.01e-01 0.89700
Signaling by NTRK2 (TRKB) 21 4.24e-01 1.01e-01 0.94500
Dectin-1 mediated noncanonical NF-kB signaling 42 2.58e-01 -1.01e-01 0.89700
Toll Like Receptor 3 (TLR3) Cascade 73 1.37e-01 1.01e-01 0.88500
Cell junction organization 69 1.50e-01 -1.00e-01 0.88800
Ub-specific processing proteases 127 5.13e-02 1.00e-01 0.85100
Mitotic G1 phase and G1/S transition 106 7.49e-02 1.00e-01 0.85100
Chaperonin-mediated protein folding 71 1.45e-01 1.00e-01 0.88500
Nucleotide salvage 17 4.75e-01 1.00e-01 0.94500
Transport of the SLBP independent Mature mRNA 23 4.08e-01 9.96e-02 0.94500
Purine ribonucleoside monophosphate biosynthesis 11 5.68e-01 9.95e-02 0.94500
PCP/CE pathway 68 1.58e-01 9.90e-02 0.89700
Regulation of gene expression by Hypoxia-inducible Factor 11 5.70e-01 9.89e-02 0.94500
Attenuation phase 16 4.96e-01 9.84e-02 0.94500
Nuclear Pore Complex (NPC) Disassembly 25 3.97e-01 9.78e-02 0.94500
Loss of Nlp from mitotic centrosomes 55 2.13e-01 9.72e-02 0.89700
Loss of proteins required for interphase microtubule organization from the centrosome 55 2.13e-01 9.72e-02 0.89700
Rap1 signalling 14 5.29e-01 9.72e-02 0.94500
RNA Polymerase III Transcription Initiation From Type 1 Promoter 17 4.89e-01 9.70e-02 0.94500
Glutamate binding, activation of AMPA receptors and synaptic plasticity 26 3.92e-01 -9.69e-02 0.94500
Trafficking of AMPA receptors 26 3.92e-01 -9.69e-02 0.94500
PKA activation in glucagon signalling 15 5.16e-01 9.69e-02 0.94500
FGFR2 mutant receptor activation 20 4.54e-01 -9.68e-02 0.94500
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 5.32e-01 9.66e-02 0.94500
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 5.32e-01 9.66e-02 0.94500
Insulin receptor signalling cascade 47 2.54e-01 -9.62e-02 0.89700
Cell Cycle, Mitotic 364 1.74e-03 9.60e-02 0.35900
Triglyceride metabolism 28 3.80e-01 -9.60e-02 0.94500
Ca2+ pathway 53 2.28e-01 9.58e-02 0.89700
Transport of the SLBP Dependant Mature mRNA 24 4.17e-01 9.57e-02 0.94500
Growth hormone receptor signaling 20 4.60e-01 9.56e-02 0.94500
COPI-mediated anterograde transport 67 1.77e-01 -9.55e-02 0.89700
Acetylcholine binding and downstream events 12 5.67e-01 -9.54e-02 0.94500
Postsynaptic nicotinic acetylcholine receptors 12 5.67e-01 -9.54e-02 0.94500
TRAF6-mediated induction of TAK1 complex within TLR4 complex 11 5.84e-01 -9.53e-02 0.94500
Selenoamino acid metabolism 48 2.55e-01 9.49e-02 0.89700
RNA Polymerase III Transcription Termination 15 5.25e-01 -9.49e-02 0.94500
Signaling by NTRKs 114 8.08e-02 9.48e-02 0.85100
Hedgehog 'on' state 57 2.16e-01 -9.47e-02 0.89700
Protein folding 77 1.51e-01 9.47e-02 0.88800
EGFR downregulation 22 4.45e-01 -9.42e-02 0.94500
FCGR activation 15 5.29e-01 -9.39e-02 0.94500
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 91 1.22e-01 -9.39e-02 0.88500
Ovarian tumor domain proteases 27 4.00e-01 9.37e-02 0.94500
SUMOylation of chromatin organization proteins 40 3.06e-01 9.36e-02 0.92300
GABA synthesis, release, reuptake and degradation 13 5.59e-01 -9.36e-02 0.94500
Signaling by high-kinase activity BRAF mutants 27 4.01e-01 9.35e-02 0.94500
Leading Strand Synthesis 12 5.75e-01 9.34e-02 0.94500
Polymerase switching 12 5.75e-01 9.34e-02 0.94500
Mitotic Prometaphase 141 5.60e-02 9.34e-02 0.85100
Gap-filling DNA repair synthesis and ligation in GG-NER 18 4.93e-01 9.33e-02 0.94500
Signaling by TGFB family members 76 1.60e-01 -9.33e-02 0.89700
Recycling of bile acids and salts 13 5.60e-01 9.33e-02 0.94500
APC-Cdc20 mediated degradation of Nek2A 20 4.71e-01 -9.31e-02 0.94500
Signaling by ROBO receptors 125 7.37e-02 9.28e-02 0.85100
Intrinsic Pathway for Apoptosis 42 3.00e-01 9.25e-02 0.91700
Diseases associated with glycosylation precursor biosynthesis 15 5.35e-01 9.25e-02 0.94500
Regulation of PTEN gene transcription 48 2.68e-01 9.24e-02 0.89800
Activated point mutants of FGFR2 14 5.50e-01 -9.22e-02 0.94500
Keratan sulfate/keratin metabolism 25 4.26e-01 9.20e-02 0.94500
RAB GEFs exchange GTP for GDP on RABs 67 1.97e-01 9.13e-02 0.89700
cGMP effects 16 5.28e-01 -9.12e-02 0.94500
Metabolism of fat-soluble vitamins 31 3.80e-01 -9.11e-02 0.94500
RHO GTPases activate PAKs 18 5.04e-01 9.10e-02 0.94500
SUMOylation of DNA methylation proteins 15 5.42e-01 9.09e-02 0.94500
PPARA activates gene expression 96 1.25e-01 9.08e-02 0.88500
RA biosynthesis pathway 18 5.05e-01 9.07e-02 0.94500
Resolution of Abasic Sites (AP sites) 30 3.91e-01 9.06e-02 0.94500
Synthesis of PIPs at the early endosome membrane 14 5.59e-01 9.02e-02 0.94500
CS/DS degradation 11 6.06e-01 -8.99e-02 0.94700
Long-term potentiation 19 4.98e-01 -8.98e-02 0.94500
TP53 Regulates Metabolic Genes 65 2.11e-01 -8.97e-02 0.89700
Retrograde neurotrophin signalling 12 5.91e-01 8.96e-02 0.94500
Nitric oxide stimulates guanylate cyclase 21 4.78e-01 -8.95e-02 0.94500
Collagen biosynthesis and modifying enzymes 54 2.57e-01 -8.92e-02 0.89700
Lagging Strand Synthesis 16 5.37e-01 8.91e-02 0.94500
IRE1alpha activates chaperones 40 3.30e-01 -8.90e-02 0.92900
Degradation of cysteine and homocysteine 11 6.09e-01 8.90e-02 0.94900
Activation of BH3-only proteins 27 4.24e-01 8.90e-02 0.94500
Reduction of cytosolic Ca++ levels 11 6.10e-01 8.89e-02 0.94900
Uptake and actions of bacterial toxins 27 4.25e-01 -8.88e-02 0.94500
p75 NTR receptor-mediated signalling 78 1.76e-01 -8.87e-02 0.89700
RHO GTPase Effectors 192 3.50e-02 8.85e-02 0.85100
Telomere Maintenance 43 3.16e-01 8.84e-02 0.92900
Rab regulation of trafficking 94 1.39e-01 8.84e-02 0.88500
PKA activation 15 5.55e-01 8.80e-02 0.94500
CTLA4 inhibitory signaling 19 5.07e-01 -8.80e-02 0.94500
Nonhomologous End-Joining (NHEJ) 24 4.56e-01 8.79e-02 0.94500
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 27 4.30e-01 8.79e-02 0.94500
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 5.43e-01 8.78e-02 0.94500
Interleukin-3, Interleukin-5 and GM-CSF signaling 33 3.83e-01 8.78e-02 0.94500
NIK-->noncanonical NF-kB signaling 39 3.44e-01 -8.76e-02 0.92900
Beta-catenin independent WNT signaling 114 1.07e-01 8.75e-02 0.88500
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 13 5.86e-01 -8.73e-02 0.94500
Potential therapeutics for SARS 26 4.44e-01 8.68e-02 0.94500
Factors involved in megakaryocyte development and platelet production 99 1.36e-01 8.68e-02 0.88500
Downregulation of TGF-beta receptor signaling 17 5.36e-01 -8.68e-02 0.94500
Amino acid transport across the plasma membrane 28 4.27e-01 -8.68e-02 0.94500
Signaling by FGFR3 in disease 18 5.24e-01 8.67e-02 0.94500
Signaling by FGFR3 point mutants in cancer 18 5.24e-01 8.67e-02 0.94500
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 5.90e-01 -8.63e-02 0.94500
Signaling by KIT in disease 17 5.38e-01 8.62e-02 0.94500
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 5.38e-01 8.62e-02 0.94500
G beta:gamma signalling through BTK 11 6.21e-01 8.61e-02 0.95500
Gamma carboxylation, hypusine formation and arylsulfatase activation 24 4.66e-01 -8.61e-02 0.94500
Signaling by EGFR 38 3.59e-01 -8.60e-02 0.93400
Base-Excision Repair, AP Site Formation 17 5.42e-01 8.54e-02 0.94500
EGR2 and SOX10-mediated initiation of Schwann cell myelination 24 4.69e-01 8.54e-02 0.94500
Nuclear import of Rev protein 23 4.80e-01 8.52e-02 0.94500
Signaling by ERBB2 in Cancer 21 5.00e-01 8.51e-02 0.94500
M Phase 263 1.79e-02 8.51e-02 0.80800
CYP2E1 reactions 10 6.41e-01 8.51e-02 0.95900
LDL clearance 16 5.58e-01 8.47e-02 0.94500
Negative regulation of NMDA receptor-mediated neuronal transmission 16 5.58e-01 -8.46e-02 0.94500
Signaling by FGFR1 40 3.55e-01 8.45e-02 0.93100
InlB-mediated entry of Listeria monocytogenes into host cell 10 6.44e-01 -8.44e-02 0.95900
SHC1 events in EGFR signaling 11 6.30e-01 -8.40e-02 0.95500
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 69 2.28e-01 8.40e-02 0.89700
Amplification of signal from the kinetochores 69 2.28e-01 8.40e-02 0.89700
Cellular response to heat stress 68 2.32e-01 8.39e-02 0.89700
Organic cation transport 10 6.49e-01 8.31e-02 0.95900
Aberrant regulation of mitotic cell cycle due to RB1 defects 30 4.33e-01 8.27e-02 0.94500
Diseases of mitotic cell cycle 30 4.33e-01 8.27e-02 0.94500
Eukaryotic Translation Termination 36 3.91e-01 8.26e-02 0.94500
Plasma lipoprotein clearance 29 4.44e-01 8.21e-02 0.94500
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 32 4.22e-01 -8.21e-02 0.94500
Interconversion of nucleotide di- and triphosphates 22 5.06e-01 8.19e-02 0.94500
Transcription of the HIV genome 45 3.42e-01 -8.19e-02 0.92900
HDR through Homologous Recombination (HRR) 43 3.53e-01 -8.18e-02 0.93100
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 33 4.16e-01 8.18e-02 0.94500
Phase 0 - rapid depolarisation 37 3.90e-01 -8.17e-02 0.94500
Mitotic Metaphase and Anaphase 173 6.44e-02 8.17e-02 0.85100
IL-6-type cytokine receptor ligand interactions 15 5.85e-01 -8.16e-02 0.94500
Processing of DNA double-strand break ends 43 3.56e-01 8.13e-02 0.93100
HATs acetylate histones 58 2.84e-01 8.13e-02 0.90400
PI-3K cascade:FGFR2 20 5.31e-01 -8.09e-02 0.94500
FGFR1 mutant receptor activation 26 4.76e-01 8.08e-02 0.94500
Costimulation by the CD28 family 51 3.19e-01 -8.07e-02 0.92900
COPI-independent Golgi-to-ER retrograde traffic 27 4.69e-01 -8.05e-02 0.94500
tRNA modification in the nucleus and cytosol 28 4.62e-01 8.03e-02 0.94500
Toll Like Receptor 9 (TLR9) Cascade 71 2.43e-01 8.03e-02 0.89700
Laminin interactions 22 5.17e-01 -7.98e-02 0.94500
G alpha (z) signalling events 36 4.09e-01 7.95e-02 0.94500
Centrosome maturation 65 2.70e-01 7.92e-02 0.89800
Recruitment of mitotic centrosome proteins and complexes 65 2.70e-01 7.92e-02 0.89800
Recruitment of NuMA to mitotic centrosomes 64 2.74e-01 7.91e-02 0.89800
Cross-presentation of soluble exogenous antigens (endosomes) 36 4.12e-01 -7.90e-02 0.94500
HCMV Late Events 38 4.00e-01 7.90e-02 0.94500
Dissolution of Fibrin Clot 13 6.22e-01 7.90e-02 0.95500
Meiotic recombination 19 5.52e-01 7.87e-02 0.94500
Platelet calcium homeostasis 22 5.23e-01 -7.87e-02 0.94500
Mitotic Anaphase 172 7.59e-02 7.86e-02 0.85100
Cell Cycle 456 4.37e-03 7.84e-02 0.58200
HSF1 activation 19 5.55e-01 7.82e-02 0.94500
Glutathione conjugation 29 4.66e-01 -7.82e-02 0.94500
TNFR1-induced NFkappaB signaling pathway 22 5.27e-01 -7.79e-02 0.94500
Regulation of localization of FOXO transcription factors 10 6.70e-01 7.78e-02 0.95900
The role of GTSE1 in G2/M progression after G2 checkpoint 41 3.89e-01 7.77e-02 0.94500
Regulation of TP53 Activity 122 1.39e-01 -7.77e-02 0.88500
RUNX1 regulates transcription of genes involved in differentiation of HSCs 50 3.44e-01 -7.74e-02 0.92900
Host Interactions of HIV factors 92 2.00e-01 7.74e-02 0.89700
MyD88 cascade initiated on plasma membrane 63 2.89e-01 7.73e-02 0.90700
Toll Like Receptor 10 (TLR10) Cascade 63 2.89e-01 7.73e-02 0.90700
Toll Like Receptor 5 (TLR5) Cascade 63 2.89e-01 7.73e-02 0.90700
GP1b-IX-V activation signalling 10 6.74e-01 7.68e-02 0.95900
Initial triggering of complement 23 5.25e-01 -7.66e-02 0.94500
Processive synthesis on the C-strand of the telomere 13 6.32e-01 7.66e-02 0.95700
DAP12 signaling 22 5.36e-01 7.63e-02 0.94500
tRNA processing in the nucleus 42 3.93e-01 7.62e-02 0.94500
Tie2 Signaling 16 5.98e-01 -7.61e-02 0.94500
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 5.19e-01 7.61e-02 0.94500
Unblocking of NMDA receptors, glutamate binding and activation 17 5.89e-01 -7.58e-02 0.94500
STING mediated induction of host immune responses 11 6.65e-01 7.54e-02 0.95900
Sphingolipid metabolism 63 3.03e-01 7.51e-02 0.91800
NOTCH1 Intracellular Domain Regulates Transcription 38 4.24e-01 7.49e-02 0.94500
Erythropoietin activates RAS 11 6.67e-01 7.49e-02 0.95900
Apoptosis 133 1.37e-01 7.48e-02 0.88500
Processive synthesis on the lagging strand 12 6.54e-01 7.47e-02 0.95900
DAP12 interactions 27 5.02e-01 7.47e-02 0.94500
Glucuronidation 16 6.05e-01 7.47e-02 0.94700
RNA Polymerase III Transcription Initiation 23 5.36e-01 7.46e-02 0.94500
Programmed Cell Death 136 1.34e-01 7.46e-02 0.88500
ZBP1(DAI) mediated induction of type I IFNs 19 5.75e-01 -7.43e-02 0.94500
Autodegradation of Cdh1 by Cdh1:APC/C 46 3.85e-01 -7.41e-02 0.94500
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 12 6.58e-01 7.38e-02 0.95900
ERBB2 Regulates Cell Motility 11 6.73e-01 -7.35e-02 0.95900
ER to Golgi Anterograde Transport 106 1.92e-01 -7.34e-02 0.89700
FRS-mediated FGFR4 signaling 17 6.01e-01 -7.33e-02 0.94500
Recognition of DNA damage by PCNA-containing replication complex 19 5.81e-01 7.32e-02 0.94500
TP53 Regulates Transcription of Cell Cycle Genes 40 4.26e-01 7.28e-02 0.94500
Fatty acid metabolism 136 1.45e-01 7.24e-02 0.88500
Regulation of lipid metabolism by PPARalpha 98 2.17e-01 7.23e-02 0.89700
Signaling by NOTCH2 24 5.40e-01 -7.23e-02 0.94500
RNA Pol II CTD phosphorylation and interaction with CE 15 6.29e-01 -7.20e-02 0.95500
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 15 6.29e-01 -7.20e-02 0.95500
Paradoxical activation of RAF signaling by kinase inactive BRAF 34 4.68e-01 7.19e-02 0.94500
Signaling by RAS mutants 34 4.68e-01 7.19e-02 0.94500
Signaling by moderate kinase activity BRAF mutants 34 4.68e-01 7.19e-02 0.94500
Signaling downstream of RAS mutants 34 4.68e-01 7.19e-02 0.94500
FGFR2 alternative splicing 14 6.41e-01 7.19e-02 0.95900
G beta:gamma signalling through PI3Kgamma 18 5.98e-01 7.18e-02 0.94500
Signaling by FGFR4 in disease 10 6.96e-01 7.15e-02 0.95900
Signaling by SCF-KIT 36 4.61e-01 7.11e-02 0.94500
Protein localization 114 1.91e-01 -7.10e-02 0.89700
Anchoring of the basal body to the plasma membrane 76 2.85e-01 7.10e-02 0.90400
APC/C:Cdc20 mediated degradation of Cyclin B 19 5.92e-01 -7.10e-02 0.94500
Formation of HIV elongation complex in the absence of HIV Tat 23 5.57e-01 -7.08e-02 0.94500
Formation of HIV-1 elongation complex containing HIV-1 Tat 23 5.57e-01 -7.08e-02 0.94500
HIV Transcription Elongation 23 5.57e-01 -7.08e-02 0.94500
Tat-mediated elongation of the HIV-1 transcript 23 5.57e-01 -7.08e-02 0.94500
Presynaptic nicotinic acetylcholine receptors 11 6.85e-01 -7.07e-02 0.95900
LGI-ADAM interactions 13 6.60e-01 -7.05e-02 0.95900
RHO GTPases Activate Formins 89 2.52e-01 7.04e-02 0.89700
ER-Phagosome pathway 55 3.68e-01 -7.03e-02 0.94500
SHC-mediated cascade:FGFR4 16 6.27e-01 -7.01e-02 0.95500
Regulation of TNFR1 signaling 25 5.45e-01 -7.00e-02 0.94500
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 31 5.02e-01 6.97e-02 0.94500
SHC1 events in ERBB4 signaling 10 7.03e-01 -6.96e-02 0.95900
Activation of the pre-replicative complex 23 5.64e-01 6.96e-02 0.94500
Interactions of Vpr with host cellular proteins 25 5.49e-01 6.92e-02 0.94500
RHO GTPases activate IQGAPs 10 7.05e-01 6.92e-02 0.95900
Metabolism of nucleotides 78 2.92e-01 6.91e-02 0.90700
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 5.35e-01 -6.91e-02 0.94500
Diseases of metabolism 193 9.94e-02 -6.90e-02 0.87200
Transport to the Golgi and subsequent modification 129 1.78e-01 -6.88e-02 0.89700
Prostacyclin signalling through prostacyclin receptor 13 6.70e-01 6.83e-02 0.95900
Signaling by EGFR in Cancer 18 6.16e-01 -6.82e-02 0.95300
RIP-mediated NFkB activation via ZBP1 15 6.48e-01 -6.80e-02 0.95900
Influenza Viral RNA Transcription and Replication 62 3.60e-01 6.73e-02 0.93400
Nucleotide Excision Repair 76 3.11e-01 6.72e-02 0.92900
Cellular hexose transport 19 6.12e-01 -6.72e-02 0.95000
Regulation of FZD by ubiquitination 14 6.64e-01 6.72e-02 0.95900
Downstream signaling of activated FGFR4 22 5.86e-01 -6.70e-02 0.94500
Ethanol oxidation 10 7.14e-01 6.69e-02 0.95900
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 6.06e-01 6.66e-02 0.94700
Negative regulation of FGFR3 signaling 21 5.98e-01 6.65e-02 0.94500
Platelet homeostasis 71 3.33e-01 -6.65e-02 0.92900
MyD88 dependent cascade initiated on endosome 68 3.45e-01 6.63e-02 0.92900
Toll Like Receptor 7/8 (TLR7/8) Cascade 68 3.45e-01 6.63e-02 0.92900
Glycogen breakdown (glycogenolysis) 12 6.91e-01 6.62e-02 0.95900
Potassium Channels 79 3.10e-01 6.62e-02 0.92800
mRNA Splicing - Minor Pathway 30 5.31e-01 -6.61e-02 0.94500
Diseases associated with glycosaminoglycan metabolism 33 5.12e-01 -6.59e-02 0.94500
Downregulation of ERBB2 signaling 19 6.19e-01 -6.58e-02 0.95500
EML4 and NUDC in mitotic spindle formation 72 3.36e-01 6.57e-02 0.92900
Regulation of RAS by GAPs 50 4.24e-01 6.55e-02 0.94500
Telomere C-strand synthesis initiation 11 7.07e-01 6.55e-02 0.95900
Regulation of HSF1-mediated heat shock response 52 4.15e-01 6.54e-02 0.94500
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 7.10e-01 6.48e-02 0.95900
Phospholipase C-mediated cascade; FGFR2 15 6.64e-01 -6.48e-02 0.95900
Regulation of beta-cell development 29 5.47e-01 6.47e-02 0.94500
Interleukin-20 family signaling 20 6.17e-01 -6.46e-02 0.95300
FCGR3A-mediated phagocytosis 55 4.08e-01 6.46e-02 0.94500
Leishmania phagocytosis 55 4.08e-01 6.46e-02 0.94500
Parasite infection 55 4.08e-01 6.46e-02 0.94500
Regulation of cholesterol biosynthesis by SREBP (SREBF) 45 4.55e-01 6.43e-02 0.94500
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 6.37e-01 -6.43e-02 0.95900
Fc epsilon receptor (FCERI) signaling 98 2.73e-01 6.42e-02 0.89800
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 4.56e-01 6.42e-02 0.94500
Major pathway of rRNA processing in the nucleolus and cytosol 98 2.73e-01 6.41e-02 0.89800
Influenza Infection 75 3.40e-01 6.38e-02 0.92900
E3 ubiquitin ligases ubiquitinate target proteins 23 5.98e-01 6.35e-02 0.94500
HIV Transcription Initiation 32 5.37e-01 -6.31e-02 0.94500
RNA Polymerase II HIV Promoter Escape 32 5.37e-01 -6.31e-02 0.94500
RNA Polymerase II Promoter Escape 32 5.37e-01 -6.31e-02 0.94500
RNA Polymerase II Transcription Initiation 32 5.37e-01 -6.31e-02 0.94500
RNA Polymerase II Transcription Initiation And Promoter Clearance 32 5.37e-01 -6.31e-02 0.94500
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 32 5.37e-01 -6.31e-02 0.94500
MyD88-independent TLR4 cascade 76 3.42e-01 6.31e-02 0.92900
TRIF(TICAM1)-mediated TLR4 signaling 76 3.42e-01 6.31e-02 0.92900
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 44 4.71e-01 6.29e-02 0.94500
Miscellaneous transport and binding events 16 6.63e-01 -6.29e-02 0.95900
Chromatin modifying enzymes 151 1.83e-01 6.28e-02 0.89700
Chromatin organization 151 1.83e-01 6.28e-02 0.89700
Collagen degradation 33 5.33e-01 -6.28e-02 0.94500
Physiological factors 10 7.31e-01 -6.27e-02 0.95900
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 14 6.87e-01 6.23e-02 0.95900
Pre-NOTCH Expression and Processing 44 4.76e-01 6.21e-02 0.94500
IKK complex recruitment mediated by RIP1 16 6.67e-01 -6.21e-02 0.95900
PTEN Regulation 106 2.72e-01 6.18e-02 0.89800
RNA Polymerase III Transcription Initiation From Type 2 Promoter 16 6.71e-01 6.14e-02 0.95900
Lysosome Vesicle Biogenesis 26 5.88e-01 6.14e-02 0.94500
SHC-mediated cascade:FGFR3 14 6.92e-01 6.12e-02 0.95900
Chondroitin sulfate/dermatan sulfate metabolism 42 4.93e-01 6.12e-02 0.94500
Formation of Incision Complex in GG-NER 29 5.69e-01 6.11e-02 0.94500
SUMO E3 ligases SUMOylate target proteins 123 2.45e-01 6.07e-02 0.89700
PI Metabolism 72 3.74e-01 6.06e-02 0.94500
Metabolism of RNA 440 3.04e-02 6.05e-02 0.85100
CD28 co-stimulation 29 5.73e-01 -6.04e-02 0.94500
Gap junction trafficking 23 6.18e-01 6.02e-02 0.95300
Caspase activation via extrinsic apoptotic signalling pathway 21 6.34e-01 -6.00e-02 0.95700
Activation of NF-kappaB in B cells 45 4.88e-01 -5.98e-02 0.94500
ERBB2 Activates PTK6 Signaling 10 7.45e-01 -5.94e-02 0.95900
GRB2 events in ERBB2 signaling 12 7.21e-01 5.94e-02 0.95900
p130Cas linkage to MAPK signaling for integrins 13 7.12e-01 5.92e-02 0.95900
Interleukin-4 and Interleukin-13 signaling 83 3.52e-01 -5.92e-02 0.93100
activated TAK1 mediates p38 MAPK activation 14 7.02e-01 -5.91e-02 0.95900
VLDLR internalisation and degradation 11 7.35e-01 5.90e-02 0.95900
Signaling by Rho GTPases 302 7.98e-02 5.88e-02 0.85100
Triglyceride biosynthesis 10 7.48e-01 5.87e-02 0.95900
APC/C-mediated degradation of cell cycle proteins 66 4.10e-01 5.87e-02 0.94500
Regulation of mitotic cell cycle 66 4.10e-01 5.87e-02 0.94500
Formation of the beta-catenin:TCF transactivating complex 29 5.86e-01 -5.85e-02 0.94500
rRNA processing 111 2.91e-01 5.81e-02 0.90700
Mitochondrial Fatty Acid Beta-Oxidation 27 6.03e-01 -5.78e-02 0.94700
Inwardly rectifying K+ channels 27 6.04e-01 -5.77e-02 0.94700
Interleukin-2 family signaling 31 5.78e-01 5.77e-02 0.94500
Post-translational protein phosphorylation 80 3.73e-01 -5.77e-02 0.94500
MAP kinase activation 49 4.86e-01 5.76e-02 0.94500
trans-Golgi Network Vesicle Budding 52 4.73e-01 5.76e-02 0.94500
Pre-NOTCH Processing in Golgi 14 7.10e-01 -5.74e-02 0.95900
BMAL1:CLOCK,NPAS2 activates circadian gene expression 20 6.57e-01 -5.74e-02 0.95900
CDK-mediated phosphorylation and removal of Cdc6 53 4.71e-01 -5.73e-02 0.94500
Plasma lipoprotein assembly, remodeling, and clearance 54 4.67e-01 -5.73e-02 0.94500
RUNX2 regulates bone development 24 6.29e-01 5.71e-02 0.95500
Signaling by FGFR3 30 5.89e-01 5.71e-02 0.94500
Cyclin E associated events during G1/S transition 58 4.53e-01 5.70e-02 0.94500
Synthesis of IP2, IP, and Ins in the cytosol 13 7.22e-01 5.69e-02 0.95900
Extra-nuclear estrogen signaling 62 4.39e-01 -5.68e-02 0.94500
Notch-HLH transcription pathway 22 6.47e-01 -5.65e-02 0.95900
GABA receptor activation 43 5.23e-01 -5.64e-02 0.94500
tRNA processing 76 3.97e-01 5.63e-02 0.94500
DNA strand elongation 23 6.43e-01 -5.58e-02 0.95900
Epigenetic regulation of gene expression 61 4.52e-01 -5.58e-02 0.94500
Neurotransmitter receptors and postsynaptic signal transmission 146 2.47e-01 -5.56e-02 0.89700
Tryptophan catabolism 12 7.39e-01 5.55e-02 0.95900
Platelet degranulation 102 3.34e-01 5.54e-02 0.92900
MAPK6/MAPK4 signaling 64 4.47e-01 5.51e-02 0.94500
Detoxification of Reactive Oxygen Species 24 6.41e-01 5.50e-02 0.95900
Mitochondrial translation initiation 56 4.78e-01 5.49e-02 0.94500
FCGR3A-mediated IL10 synthesis 37 5.64e-01 5.49e-02 0.94500
Cell-Cell communication 98 3.50e-01 -5.48e-02 0.93100
G2/M DNA damage checkpoint 43 5.35e-01 5.47e-02 0.94500
Signaling by ERBB2 37 5.65e-01 -5.47e-02 0.94500
Adenylate cyclase inhibitory pathway 13 7.33e-01 -5.46e-02 0.95900
Transmission across Chemical Synapses 193 1.93e-01 -5.45e-02 0.89700
Interleukin-15 signaling 11 7.55e-01 5.44e-02 0.96000
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 23 6.53e-01 -5.42e-02 0.95900
Cytokine Signaling in Immune system 622 2.24e-02 5.41e-02 0.80800
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 40 5.54e-01 5.41e-02 0.94500
Misspliced GSK3beta mutants stabilize beta-catenin 13 7.37e-01 -5.38e-02 0.95900
S33 mutants of beta-catenin aren't phosphorylated 13 7.37e-01 -5.38e-02 0.95900
S37 mutants of beta-catenin aren't phosphorylated 13 7.37e-01 -5.38e-02 0.95900
S45 mutants of beta-catenin aren't phosphorylated 13 7.37e-01 -5.38e-02 0.95900
T41 mutants of beta-catenin aren't phosphorylated 13 7.37e-01 -5.38e-02 0.95900
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 13 7.37e-01 -5.38e-02 0.95900
Nicotinate metabolism 21 6.71e-01 -5.36e-02 0.95900
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 67 4.49e-01 5.36e-02 0.94500
Processing of Capped Intron-Containing Pre-mRNA 164 2.39e-01 5.34e-02 0.89700
ADP signalling through P2Y purinoceptor 1 19 6.88e-01 5.32e-02 0.95900
Molecules associated with elastic fibres 28 6.27e-01 -5.31e-02 0.95500
Cellular response to hypoxia 53 5.04e-01 5.31e-02 0.94500
Beta-catenin phosphorylation cascade 15 7.23e-01 5.30e-02 0.95900
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 7.15e-01 5.28e-02 0.95900
Signaling by ERBB4 43 5.50e-01 -5.27e-02 0.94500
S Phase 120 3.21e-01 5.25e-02 0.92900
SUMOylation 128 3.10e-01 5.21e-02 0.92800
ABC transporters in lipid homeostasis 13 7.46e-01 5.19e-02 0.95900
TNFR1-induced proapoptotic signaling 12 7.57e-01 5.17e-02 0.96000
RMTs methylate histone arginines 26 6.49e-01 5.16e-02 0.95900
Diseases of carbohydrate metabolism 25 6.58e-01 5.12e-02 0.95900
FGFR2 ligand binding and activation 16 7.23e-01 -5.11e-02 0.95900
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 22 6.80e-01 5.08e-02 0.95900
Regulation of Glucokinase by Glucokinase Regulatory Protein 22 6.80e-01 5.08e-02 0.95900
Biological oxidations 167 2.61e-01 5.05e-02 0.89800
ROS and RNS production in phagocytes 26 6.56e-01 5.05e-02 0.95900
Autodegradation of the E3 ubiquitin ligase COP1 36 6.01e-01 -5.04e-02 0.94500
Dual incision in TC-NER 44 5.64e-01 5.02e-02 0.94500
Activation of ATR in response to replication stress 23 6.77e-01 5.02e-02 0.95900
DNA Double Strand Break Response 34 6.14e-01 5.00e-02 0.95100
Cellular responses to stress 338 1.16e-01 4.99e-02 0.88500
Class A/1 (Rhodopsin-like receptors) 252 1.76e-01 -4.97e-02 0.89700
Keratinization 94 4.06e-01 -4.96e-02 0.94500
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 32 6.27e-01 -4.96e-02 0.95500
RAF activation 28 6.50e-01 4.96e-02 0.95900
rRNA processing in the nucleus and cytosol 104 3.84e-01 4.95e-02 0.94500
Trafficking of GluR2-containing AMPA receptors 13 7.58e-01 4.95e-02 0.96000
Acyl chain remodelling of PG 15 7.42e-01 -4.90e-02 0.95900
Phospholipase C-mediated cascade; FGFR3 10 7.89e-01 4.90e-02 0.96400
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 68 4.87e-01 4.88e-02 0.94500
Signaling by ERBB2 TMD/JMD mutants 17 7.28e-01 4.88e-02 0.95900
FRS-mediated FGFR3 signaling 15 7.44e-01 4.88e-02 0.95900
Synthesis of bile acids and bile salts 25 6.74e-01 -4.86e-02 0.95900
Negative regulators of DDX58/IFIH1 signaling 22 6.94e-01 -4.85e-02 0.95900
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 20 7.09e-01 -4.83e-02 0.95900
Transport of inorganic cations/anions and amino acids/oligopeptides 90 4.29e-01 -4.83e-02 0.94500
Olfactory Signaling Pathway 146 3.16e-01 -4.82e-02 0.92900
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 13 7.64e-01 4.81e-02 0.96100
Estrogen-dependent gene expression 72 4.81e-01 4.80e-02 0.94500
Cyclin A:Cdk2-associated events at S phase entry 60 5.21e-01 4.79e-02 0.94500
Phosphorylation of CD3 and TCR zeta chains 14 7.56e-01 -4.79e-02 0.96000
Pre-NOTCH Transcription and Translation 31 6.45e-01 4.79e-02 0.95900
G alpha (s) signalling events 261 1.85e-01 -4.79e-02 0.89700
Cell Cycle Checkpoints 186 2.62e-01 4.79e-02 0.89800
Intra-Golgi and retrograde Golgi-to-ER traffic 142 3.26e-01 -4.79e-02 0.92900
APC/C:Cdc20 mediated degradation of Securin 50 5.59e-01 -4.78e-02 0.94500
Metabolism of folate and pterines 14 7.59e-01 -4.74e-02 0.96000
SLC-mediated transmembrane transport 206 2.42e-01 4.74e-02 0.89700
Mitotic Spindle Checkpoint 84 4.53e-01 4.74e-02 0.94500
Signaling by Leptin 10 7.96e-01 4.73e-02 0.96400
Homology Directed Repair 72 4.88e-01 4.73e-02 0.94500
Metabolism of carbohydrates 222 2.26e-01 -4.73e-02 0.89700
Mitophagy 18 7.29e-01 4.72e-02 0.95900
Death Receptor Signalling 113 3.87e-01 -4.72e-02 0.94500
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 7.29e-01 -4.72e-02 0.95900
Ca-dependent events 30 6.55e-01 4.71e-02 0.95900
Bile acid and bile salt metabolism 32 6.45e-01 4.71e-02 0.95900
Collagen chain trimerization 39 6.12e-01 -4.69e-02 0.95000
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 15 7.54e-01 4.68e-02 0.96000
DNA Repair 200 2.55e-01 4.68e-02 0.89700
Signal amplification 24 6.92e-01 -4.68e-02 0.95900
FOXO-mediated transcription of cell cycle genes 14 7.62e-01 -4.67e-02 0.96100
Regulation of IFNG signaling 10 8.00e-01 -4.63e-02 0.96600
PI-3K cascade:FGFR1 19 7.27e-01 -4.63e-02 0.95900
Signaling by ERBB2 KD Mutants 20 7.22e-01 4.60e-02 0.95900
Repression of WNT target genes 11 7.92e-01 4.60e-02 0.96400
Visual phototransduction 74 4.98e-01 -4.56e-02 0.94500
Cellular responses to external stimuli 345 1.47e-01 4.56e-02 0.88800
Synthesis of PE 10 8.03e-01 4.55e-02 0.96700
Digestion 16 7.54e-01 -4.53e-02 0.96000
Cytosolic sulfonation of small molecules 17 7.47e-01 -4.52e-02 0.95900
Branched-chain amino acid catabolism 19 7.33e-01 4.52e-02 0.95900
EPH-ephrin mediated repulsion of cells 39 6.26e-01 -4.51e-02 0.95500
Cytosolic sensors of pathogen-associated DNA 46 5.98e-01 4.50e-02 0.94500
Creatine metabolism 10 8.06e-01 4.50e-02 0.96700
PD-1 signaling 13 7.79e-01 -4.49e-02 0.96200
Fanconi Anemia Pathway 23 7.09e-01 -4.49e-02 0.95900
BBSome-mediated cargo-targeting to cilium 18 7.42e-01 4.49e-02 0.95900
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 66 5.29e-01 -4.49e-02 0.94500
Global Genome Nucleotide Excision Repair (GG-NER) 61 5.45e-01 4.48e-02 0.94500
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 46 6.00e-01 4.47e-02 0.94500
Constitutive Signaling by NOTCH1 PEST Domain Mutants 46 6.00e-01 4.47e-02 0.94500
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 46 6.00e-01 4.47e-02 0.94500
Signaling by NOTCH1 PEST Domain Mutants in Cancer 46 6.00e-01 4.47e-02 0.94500
Signaling by NOTCH1 in Cancer 46 6.00e-01 4.47e-02 0.94500
Chemokine receptors bind chemokines 38 6.35e-01 -4.46e-02 0.95700
mRNA Capping 16 7.58e-01 -4.44e-02 0.96000
Thrombin signalling through proteinase activated receptors (PARs) 24 7.07e-01 -4.44e-02 0.95900
TBC/RABGAPs 33 6.61e-01 4.41e-02 0.95900
Stabilization of p53 39 6.34e-01 -4.40e-02 0.95700
Late Phase of HIV Life Cycle 87 4.79e-01 -4.39e-02 0.94500
Constitutive Signaling by Aberrant PI3K in Cancer 64 5.45e-01 -4.38e-02 0.94500
Gap junction assembly 15 7.70e-01 -4.36e-02 0.96200
NOTCH3 Intracellular Domain Regulates Transcription 22 7.24e-01 4.35e-02 0.95900
Gap junction trafficking and regulation 25 7.07e-01 4.35e-02 0.95900
DNA Replication Pre-Initiation 59 5.64e-01 4.35e-02 0.94500
Signaling by FGFR2 50 5.96e-01 4.34e-02 0.94500
Inhibition of DNA recombination at telomere 12 7.95e-01 4.33e-02 0.96400
Viral Messenger RNA Synthesis 25 7.09e-01 4.32e-02 0.95900
Downregulation of SMAD2/3:SMAD4 transcriptional activity 15 7.73e-01 -4.31e-02 0.96200
Degradation of AXIN 37 6.50e-01 -4.31e-02 0.95900
Semaphorin interactions 54 5.85e-01 -4.30e-02 0.94500
Gene Silencing by RNA 52 5.92e-01 4.29e-02 0.94500
EPH-Ephrin signaling 73 5.27e-01 -4.29e-02 0.94500
GPCR downstream signalling 694 5.71e-02 -4.28e-02 0.85100
RET signaling 36 6.58e-01 -4.26e-02 0.95900
FGFR1 ligand binding and activation 13 7.91e-01 -4.25e-02 0.96400
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 8.00e-01 4.24e-02 0.96600
UCH proteinases 61 5.68e-01 4.23e-02 0.94500
Mitochondrial biogenesis 61 5.71e-01 4.20e-02 0.94500
Signaling by GPCR 740 5.49e-02 -4.19e-02 0.85100
G2/M Checkpoints 91 4.91e-01 4.19e-02 0.94500
Oncogenic MAPK signaling 61 5.72e-01 4.18e-02 0.94500
Chromosome Maintenance 57 5.85e-01 4.18e-02 0.94500
Separation of Sister Chromatids 126 4.19e-01 4.18e-02 0.94500
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 54 5.96e-01 4.18e-02 0.94500
HCMV Infection 60 5.76e-01 4.17e-02 0.94500
Stimuli-sensing channels 78 5.24e-01 -4.17e-02 0.94500
Signaling by VEGF 91 4.92e-01 -4.17e-02 0.94500
Adrenaline,noradrenaline inhibits insulin secretion 22 7.35e-01 4.17e-02 0.95900
MTOR signalling 31 6.89e-01 4.16e-02 0.95900
Signaling by Interleukins 323 2.02e-01 4.15e-02 0.89700
Transcriptional regulation of pluripotent stem cells 22 7.36e-01 -4.15e-02 0.95900
Cleavage of the damaged pyrimidine 15 7.81e-01 4.14e-02 0.96200
Depyrimidination 15 7.81e-01 4.14e-02 0.96200
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 15 7.81e-01 4.14e-02 0.96200
FOXO-mediated transcription 55 5.96e-01 4.14e-02 0.94500
NR1H2 and NR1H3-mediated signaling 40 6.53e-01 4.10e-02 0.95900
G-protein activation 20 7.52e-01 -4.08e-02 0.96000
Asparagine N-linked glycosylation 218 3.02e-01 -4.07e-02 0.91800
Apoptotic factor-mediated response 11 8.16e-01 4.06e-02 0.96700
Presynaptic depolarization and calcium channel opening 11 8.16e-01 -4.05e-02 0.96700
VEGFA-VEGFR2 Pathway 85 5.21e-01 -4.04e-02 0.94500
Respiratory electron transport 60 5.90e-01 -4.02e-02 0.94500
Scavenging by Class A Receptors 14 7.94e-01 4.02e-02 0.96400
Neuronal System 306 2.30e-01 -4.01e-02 0.89700
Reproduction 65 5.77e-01 4.00e-02 0.94500
Glycogen metabolism 21 7.52e-01 -3.98e-02 0.96000
MET promotes cell motility 26 7.26e-01 3.98e-02 0.95900
HSF1-dependent transactivation 25 7.32e-01 3.95e-02 0.95900
Senescence-Associated Secretory Phenotype (SASP) 39 6.70e-01 -3.95e-02 0.95900
Metal ion SLC transporters 19 7.66e-01 -3.95e-02 0.96200
Phospholipid metabolism 163 3.87e-01 3.94e-02 0.94500
Translation 156 4.01e-01 3.91e-02 0.94500
VEGFR2 mediated cell proliferation 19 7.70e-01 3.88e-02 0.96200
Peroxisomal lipid metabolism 23 7.48e-01 -3.87e-02 0.95900
Interleukin-37 signaling 15 7.95e-01 3.87e-02 0.96400
Metabolism of Angiotensinogen to Angiotensins 13 8.09e-01 3.86e-02 0.96700
TCR signaling 83 5.44e-01 3.86e-02 0.94500
Regulation of APC/C activators between G1/S and early anaphase 59 6.08e-01 3.86e-02 0.94900
Downstream signaling of activated FGFR2 25 7.40e-01 -3.83e-02 0.95900
Formation of RNA Pol II elongation complex 33 7.04e-01 3.82e-02 0.95900
RNA Polymerase II Transcription Elongation 33 7.04e-01 3.82e-02 0.95900
Defects in vitamin and cofactor metabolism 15 7.99e-01 3.81e-02 0.96600
Mitochondrial translation elongation 56 6.23e-01 3.80e-02 0.95500
NS1 Mediated Effects on Host Pathways 26 7.38e-01 3.79e-02 0.95900
Telomere C-strand (Lagging Strand) Synthesis 25 7.43e-01 3.79e-02 0.95900
Integration of energy metabolism 94 5.27e-01 3.78e-02 0.94500
Downstream signaling events of B Cell Receptor (BCR) 57 6.23e-01 -3.77e-02 0.95500
Nicotinamide salvaging 11 8.29e-01 -3.76e-02 0.96800
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 5.85e-01 3.76e-02 0.94500
Toll Like Receptor 2 (TLR2) Cascade 71 5.85e-01 3.76e-02 0.94500
Toll Like Receptor TLR1:TLR2 Cascade 71 5.85e-01 3.76e-02 0.94500
Toll Like Receptor TLR6:TLR2 Cascade 71 5.85e-01 3.76e-02 0.94500
HDACs deacetylate histones 22 7.61e-01 3.75e-02 0.96000
Interleukin-1 signaling 73 5.81e-01 3.74e-02 0.94500
Dual Incision in GG-NER 32 7.15e-01 3.74e-02 0.95900
Orc1 removal from chromatin 49 6.52e-01 3.72e-02 0.95900
Response to elevated platelet cytosolic Ca2+ 106 5.09e-01 3.72e-02 0.94500
Diseases associated with N-glycosylation of proteins 14 8.10e-01 -3.71e-02 0.96700
Cell death signalling via NRAGE, NRIF and NADE 62 6.14e-01 -3.71e-02 0.95100
mRNA Splicing - Major Pathway 118 4.90e-01 3.68e-02 0.94500
NRAGE signals death through JNK 53 6.43e-01 -3.68e-02 0.95900
Transcriptional Regulation by TP53 261 3.09e-01 -3.67e-02 0.92800
COPII-mediated vesicle transport 51 6.52e-01 3.65e-02 0.95900
Signaling by PDGF 47 6.65e-01 -3.65e-02 0.95900
FRS-mediated FGFR2 signaling 20 7.77e-01 -3.65e-02 0.96200
Signaling by Retinoic Acid 38 6.97e-01 -3.65e-02 0.95900
CLEC7A (Dectin-1) signaling 71 5.98e-01 -3.62e-02 0.94500
Zinc transporters 12 8.29e-01 -3.59e-02 0.96800
Translesion synthesis by POLI 12 8.30e-01 -3.58e-02 0.96800
Translesion synthesis by REV1 11 8.38e-01 -3.57e-02 0.96800
TNF signaling 32 7.27e-01 -3.57e-02 0.95900
Activation of NMDA receptors and postsynaptic events 63 6.25e-01 -3.56e-02 0.95500
Presynaptic function of Kainate receptors 15 8.11e-01 3.56e-02 0.96700
Interleukin-1 family signaling 99 5.46e-01 3.51e-02 0.94500
Termination of translesion DNA synthesis 22 7.76e-01 3.51e-02 0.96200
G-protein mediated events 46 6.82e-01 -3.49e-02 0.95900
DNA Damage Recognition in GG-NER 26 7.58e-01 -3.49e-02 0.96000
Glucose metabolism 72 6.10e-01 -3.48e-02 0.94900
The citric acid (TCA) cycle and respiratory electron transport 103 5.47e-01 -3.44e-02 0.94500
DCC mediated attractive signaling 12 8.37e-01 3.44e-02 0.96800
G beta:gamma signalling through PLC beta 14 8.24e-01 3.43e-02 0.96800
PINK1-PRKN Mediated Mitophagy 14 8.25e-01 -3.41e-02 0.96800
Signaling by MET 55 6.63e-01 -3.40e-02 0.95900
Interleukin-17 signaling 55 6.66e-01 3.37e-02 0.95900
SCF(Skp2)-mediated degradation of p27/p21 41 7.10e-01 3.36e-02 0.95900
Hh mutants abrogate ligand secretion 39 7.16e-01 -3.36e-02 0.95900
AMER1 mutants destabilize the destruction complex 12 8.41e-01 -3.34e-02 0.96800
APC truncation mutants have impaired AXIN binding 12 8.41e-01 -3.34e-02 0.96800
AXIN missense mutants destabilize the destruction complex 12 8.41e-01 -3.34e-02 0.96800
AXIN mutants destabilize the destruction complex, activating WNT signaling 12 8.41e-01 -3.34e-02 0.96800
Truncations of AMER1 destabilize the destruction complex 12 8.41e-01 -3.34e-02 0.96800
truncated APC mutants destabilize the destruction complex 12 8.41e-01 -3.34e-02 0.96800
Unfolded Protein Response (UPR) 67 6.40e-01 -3.31e-02 0.95900
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 88 5.97e-01 -3.26e-02 0.94500
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 7.83e-01 3.26e-02 0.96200
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 27 7.71e-01 3.24e-02 0.96200
Neddylation 171 4.67e-01 -3.23e-02 0.94500
Assembly and cell surface presentation of NMDA receptors 21 8.00e-01 -3.19e-02 0.96600
Regulation of actin dynamics for phagocytic cup formation 56 6.80e-01 3.19e-02 0.95900
SHC-mediated cascade:FGFR2 19 8.10e-01 -3.19e-02 0.96700
Neutrophil degranulation 339 3.17e-01 -3.18e-02 0.92900
NCAM signaling for neurite out-growth 48 7.05e-01 -3.16e-02 0.95900
Cardiac conduction 114 5.66e-01 3.12e-02 0.94500
DAG and IP3 signaling 34 7.53e-01 3.12e-02 0.96000
AUF1 (hnRNP D0) binds and destabilizes mRNA 37 7.47e-01 -3.07e-02 0.95900
Polymerase switching on the C-strand of the telomere 21 8.08e-01 3.06e-02 0.96700
Oxidative Stress Induced Senescence 53 7.00e-01 -3.06e-02 0.95900
Hedgehog 'off' state 74 6.53e-01 3.03e-02 0.95900
Interaction between L1 and Ankyrins 27 7.86e-01 3.02e-02 0.96300
Signaling by FGFR 62 6.82e-01 3.01e-02 0.95900
Ephrin signaling 17 8.30e-01 3.01e-02 0.96800
Infection with Mycobacterium tuberculosis 22 8.09e-01 2.97e-02 0.96700
Cargo recognition for clathrin-mediated endocytosis 76 6.56e-01 -2.96e-02 0.95900
Post NMDA receptor activation events 53 7.10e-01 -2.96e-02 0.95900
Metabolism of vitamins and cofactors 138 5.50e-01 -2.95e-02 0.94500
CRMPs in Sema3A signaling 14 8.48e-01 -2.95e-02 0.97200
Classical antibody-mediated complement activation 10 8.72e-01 -2.94e-02 0.97800
Degradation of beta-catenin by the destruction complex 62 6.90e-01 2.93e-02 0.95900
ABC transporter disorders 53 7.12e-01 -2.93e-02 0.95900
TICAM1, RIP1-mediated IKK complex recruitment 13 8.55e-01 2.92e-02 0.97400
GRB2 events in EGFR signaling 10 8.75e-01 -2.88e-02 0.97800
rRNA modification in the nucleus and cytosol 43 7.46e-01 -2.86e-02 0.95900
Regulation of mRNA stability by proteins that bind AU-rich elements 61 7.00e-01 2.85e-02 0.95900
Amine ligand-binding receptors 34 7.74e-01 -2.85e-02 0.96200
Voltage gated Potassium channels 31 7.84e-01 -2.84e-02 0.96300
Muscle contraction 170 5.24e-01 2.84e-02 0.94500
Complex I biogenesis 35 7.73e-01 2.82e-02 0.96200
SHC1 events in ERBB2 signaling 18 8.37e-01 2.81e-02 0.96800
Opioid Signalling 73 6.80e-01 2.80e-02 0.95900
Regulation of ornithine decarboxylase (ODC) 36 7.73e-01 2.78e-02 0.96200
Neurotransmitter release cycle 36 7.74e-01 -2.77e-02 0.96200
Peptide hormone metabolism 63 7.04e-01 2.77e-02 0.95900
AKT phosphorylates targets in the cytosol 13 8.63e-01 -2.76e-02 0.97700
ADP signalling through P2Y purinoceptor 12 15 8.53e-01 -2.76e-02 0.97400
Signaling by Hedgehog 100 6.35e-01 -2.75e-02 0.95700
RNA Polymerase II Transcription 822 1.85e-01 2.75e-02 0.89700
Activation of G protein gated Potassium channels 21 8.27e-01 2.75e-02 0.96800
G protein gated Potassium channels 21 8.27e-01 2.75e-02 0.96800
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 21 8.27e-01 2.75e-02 0.96800
RNA polymerase II transcribes snRNA genes 46 7.47e-01 -2.75e-02 0.95900
Signaling by BRAF and RAF fusions 49 7.40e-01 2.74e-02 0.95900
Nucleobase biosynthesis 13 8.65e-01 2.73e-02 0.97700
Antigen processing: Ubiquitination & Proteasome degradation 232 4.77e-01 2.72e-02 0.94500
Gene expression (Transcription) 920 1.68e-01 2.71e-02 0.89700
Mitochondrial translation termination 56 7.26e-01 2.71e-02 0.95900
Activation of the phototransduction cascade 11 8.77e-01 -2.69e-02 0.97900
Negative regulation of FGFR1 signaling 25 8.16e-01 2.69e-02 0.96700
Retrograde transport at the Trans-Golgi-Network 37 7.78e-01 -2.68e-02 0.96200
FGFR3 ligand binding and activation 10 8.85e-01 -2.65e-02 0.98400
FGFR3c ligand binding and activation 10 8.85e-01 -2.65e-02 0.98400
Signaling by Insulin receptor 60 7.24e-01 -2.64e-02 0.95900
GPVI-mediated activation cascade 25 8.20e-01 2.63e-02 0.96800
HIV Infection 155 5.75e-01 2.62e-02 0.94500
RUNX3 regulates NOTCH signaling 13 8.70e-01 2.61e-02 0.97800
PIP3 activates AKT signaling 210 5.21e-01 2.58e-02 0.94500
Negative regulation of FGFR4 signaling 23 8.34e-01 -2.53e-02 0.96800
Downstream signaling of activated FGFR3 20 8.45e-01 2.53e-02 0.97000
RHO GTPases Activate ROCKs 13 8.75e-01 2.52e-02 0.97800
Post-translational modification: synthesis of GPI-anchored proteins 67 7.25e-01 2.49e-02 0.95900
TNFR2 non-canonical NF-kB pathway 69 7.23e-01 2.47e-02 0.95900
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 22 8.42e-01 -2.46e-02 0.96800
Formation of Fibrin Clot (Clotting Cascade) 31 8.14e-01 2.44e-02 0.96700
SUMOylation of transcription cofactors 33 8.09e-01 -2.43e-02 0.96700
Metabolism of polyamines 42 7.86e-01 2.43e-02 0.96300
Formation of the Early Elongation Complex 19 8.55e-01 2.42e-02 0.97400
Formation of the HIV-1 Early Elongation Complex 19 8.55e-01 2.42e-02 0.97400
Regulation of insulin secretion 65 7.37e-01 -2.42e-02 0.95900
Activation of kainate receptors upon glutamate binding 24 8.39e-01 -2.40e-02 0.96800
mRNA Splicing 125 6.44e-01 2.40e-02 0.95900
Intracellular signaling by second messengers 243 5.23e-01 2.39e-02 0.94500
Transcriptional Regulation by MECP2 48 7.77e-01 2.37e-02 0.96200
Vpu mediated degradation of CD4 35 8.10e-01 -2.35e-02 0.96700
Glycosphingolipid metabolism 31 8.22e-01 2.33e-02 0.96800
Transcriptional regulation by RUNX2 84 7.13e-01 2.33e-02 0.95900
Phosphorylation of the APC/C 17 8.69e-01 -2.32e-02 0.97800
Assembly of the pre-replicative complex 47 7.84e-01 2.31e-02 0.96300
Cytochrome P450 - arranged by substrate type 53 7.74e-01 -2.28e-02 0.96200
Carboxyterminal post-translational modifications of tubulin 32 8.25e-01 -2.26e-02 0.96800
Signaling by Hippo 17 8.72e-01 2.25e-02 0.97800
Signaling by NOTCH4 62 7.60e-01 2.25e-02 0.96000
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 13 8.89e-01 2.24e-02 0.98500
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 55 7.76e-01 -2.22e-02 0.96200
Interleukin-6 family signaling 20 8.64e-01 -2.21e-02 0.97700
Toll Like Receptor 4 (TLR4) Cascade 98 7.05e-01 2.21e-02 0.95900
B-WICH complex positively regulates rRNA expression 21 8.61e-01 -2.21e-02 0.97600
NOD1/2 Signaling Pathway 24 8.51e-01 2.21e-02 0.97300
Glycerophospholipid biosynthesis 91 7.16e-01 2.21e-02 0.95900
Negative regulation of the PI3K/AKT network 93 7.15e-01 -2.19e-02 0.95900
PKMTs methylate histone lysines 32 8.31e-01 2.19e-02 0.96800
Transcriptional regulation by RUNX1 136 6.65e-01 -2.15e-02 0.95900
Signal regulatory protein family interactions 11 9.02e-01 2.15e-02 0.98800
Signaling by WNT 209 5.93e-01 2.15e-02 0.94500
Energy dependent regulation of mTOR by LKB1-AMPK 21 8.65e-01 -2.14e-02 0.97700
Phase II - Conjugation of compounds 79 7.45e-01 -2.12e-02 0.95900
Formation of TC-NER Pre-Incision Complex 33 8.34e-01 2.11e-02 0.96800
RAB geranylgeranylation 41 8.16e-01 -2.11e-02 0.96700
Metabolism of lipids 560 4.10e-01 2.05e-02 0.94500
DNA Replication 95 7.31e-01 2.04e-02 0.95900
Glycolysis 55 7.94e-01 2.04e-02 0.96400
PLC beta mediated events 45 8.13e-01 -2.04e-02 0.96700
Transport of small molecules 557 4.17e-01 2.02e-02 0.94500
Metabolism of amino acids and derivatives 250 5.83e-01 -2.02e-02 0.94500
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 31 8.47e-01 -2.01e-02 0.97100
G alpha (q) signalling events 168 6.54e-01 -2.01e-02 0.95900
Hedgehog ligand biogenesis 45 8.16e-01 -2.00e-02 0.96700
PI3K/AKT Signaling in Cancer 87 7.47e-01 -2.00e-02 0.95900
Cargo trafficking to the periciliary membrane 37 8.33e-01 -2.00e-02 0.96800
VxPx cargo-targeting to cilium 15 8.95e-01 1.97e-02 0.98600
Elastic fibre formation 33 8.45e-01 -1.97e-02 0.97000
Anti-inflammatory response favouring Leishmania parasite infection 141 6.87e-01 -1.97e-02 0.95900
Leishmania parasite growth and survival 141 6.87e-01 -1.97e-02 0.95900
Dopamine Neurotransmitter Release Cycle 16 8.92e-01 -1.96e-02 0.98500
PIWI-interacting RNA (piRNA) biogenesis 18 8.86e-01 -1.96e-02 0.98400
Signaling by the B Cell Receptor (BCR) 81 7.61e-01 1.96e-02 0.96000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 64 7.90e-01 -1.92e-02 0.96400
Interleukin receptor SHC signaling 19 8.85e-01 -1.92e-02 0.98400
Downstream TCR signaling 66 7.90e-01 1.90e-02 0.96400
Signaling by FGFR2 in disease 29 8.61e-01 -1.88e-02 0.97600
TP53 Regulates Transcription of Cell Death Genes 30 8.60e-01 1.86e-02 0.97600
Infectious disease 519 4.74e-01 1.85e-02 0.94500
Endosomal Sorting Complex Required For Transport (ESCRT) 20 8.86e-01 -1.85e-02 0.98400
Signaling by NOTCH1 58 8.08e-01 -1.84e-02 0.96700
Acyl chain remodelling of PI 14 9.06e-01 -1.83e-02 0.98900
Ion transport by P-type ATPases 42 8.38e-01 -1.82e-02 0.96800
G alpha (i) signalling events 292 5.98e-01 -1.80e-02 0.94500
Peroxisomal protein import 48 8.29e-01 1.80e-02 0.96800
Mitochondrial translation 62 8.07e-01 1.80e-02 0.96700
Listeria monocytogenes entry into host cells 14 9.08e-01 1.78e-02 0.99100
Metabolism of steroids 118 7.40e-01 -1.77e-02 0.95900
Glycosaminoglycan metabolism 93 7.72e-01 -1.74e-02 0.96200
Creation of C4 and C2 activators 17 9.02e-01 1.73e-02 0.98800
Peptide ligand-binding receptors 149 7.17e-01 -1.72e-02 0.95900
Metabolism of water-soluble vitamins and cofactors 90 7.79e-01 -1.72e-02 0.96200
Acyl chain remodelling of PE 19 8.97e-01 -1.71e-02 0.98600
Nucleobase catabolism 29 8.74e-01 1.70e-02 0.97800
TP53 Regulates Transcription of DNA Repair Genes 38 8.57e-01 1.69e-02 0.97400
Phospholipase C-mediated cascade: FGFR1 14 9.14e-01 -1.67e-02 0.99300
Generic Transcription Pathway 737 4.49e-01 1.66e-02 0.94500
Clathrin-mediated endocytosis 107 7.70e-01 -1.64e-02 0.96200
Inactivation of APC/C via direct inhibition of the APC/C complex 18 9.05e-01 -1.63e-02 0.98900
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 18 9.05e-01 -1.63e-02 0.98900
APC/C:Cdc20 mediated degradation of mitotic proteins 57 8.32e-01 1.63e-02 0.96800
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 57 8.32e-01 1.63e-02 0.96800
CDT1 association with the CDC6:ORC:origin complex 40 8.60e-01 1.61e-02 0.97600
DNA Double-Strand Break Repair 93 7.91e-01 1.60e-02 0.96400
HIV Life Cycle 95 7.93e-01 -1.56e-02 0.96400
Cobalamin (Cbl, vitamin B12) transport and metabolism 10 9.34e-01 1.52e-02 0.99500
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 36 8.75e-01 -1.52e-02 0.97800
Degradation of DVL 39 8.71e-01 1.51e-02 0.97800
Immune System 1495 3.46e-01 1.49e-02 0.92900
MAPK family signaling cascades 240 7.00e-01 1.45e-02 0.95900
Apoptotic cleavage of cell adhesion proteins 10 9.37e-01 1.45e-02 0.99500
SLC transporter disorders 80 8.28e-01 1.41e-02 0.96800
RHO GTPases Activate NADPH Oxidases 20 9.14e-01 1.40e-02 0.99300
ADORA2B mediated anti-inflammatory cytokines production 108 8.05e-01 -1.37e-02 0.96700
Purine catabolism 16 9.25e-01 -1.35e-02 0.99500
Macroautophagy 85 8.32e-01 -1.33e-02 0.96800
HSP90 chaperone cycle for steroid hormone receptors (SHR) 30 9.00e-01 -1.33e-02 0.98700
RNA Polymerase III Chain Elongation 11 9.39e-01 1.33e-02 0.99500
Activation of the TFAP2 (AP-2) family of transcription factors 10 9.42e-01 -1.33e-02 0.99500
EPHB-mediated forward signaling 24 9.10e-01 1.33e-02 0.99100
Uptake and function of anthrax toxins 11 9.39e-01 1.33e-02 0.99500
Defective CFTR causes cystic fibrosis 40 8.86e-01 -1.31e-02 0.98400
Organelle biogenesis and maintenance 209 7.45e-01 1.31e-02 0.95900
Ubiquitin-dependent degradation of Cyclin D 36 8.93e-01 1.30e-02 0.98500
ABC-family proteins mediated transport 71 8.51e-01 -1.29e-02 0.97300
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 54 8.70e-01 1.29e-02 0.97800
Vesicle-mediated transport 504 6.27e-01 -1.27e-02 0.95500
Platelet activation, signaling and aggregation 204 7.58e-01 1.25e-02 0.96000
Regulation of Apoptosis 36 8.98e-01 -1.24e-02 0.98600
SUMOylation of transcription factors 14 9.37e-01 1.22e-02 0.99500
Signaling by NTRK3 (TRKC) 15 9.35e-01 1.21e-02 0.99500
Degradation of GLI2 by the proteasome 41 8.94e-01 1.20e-02 0.98600
MAP3K8 (TPL2)-dependent MAPK1/3 activation 11 9.46e-01 -1.19e-02 0.99500
Degradation of GLI1 by the proteasome 40 8.98e-01 -1.17e-02 0.98600
Abacavir transport and metabolism 10 9.50e-01 1.16e-02 0.99500
Signaling by FGFR in disease 46 8.93e-01 1.15e-02 0.98500
TRAF6 mediated NF-kB activation 20 9.30e-01 -1.14e-02 0.99500
Class I MHC mediated antigen processing & presentation 274 7.49e-01 -1.13e-02 0.95900
Metabolism of cofactors 18 9.36e-01 1.10e-02 0.99500
Vitamin B5 (pantothenate) metabolism 13 9.47e-01 1.07e-02 0.99500
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 10 9.53e-01 -1.07e-02 0.99500
Caspase activation via Death Receptors in the presence of ligand 14 9.46e-01 -1.05e-02 0.99500
GLI3 is processed to GLI3R by the proteasome 40 9.09e-01 1.05e-02 0.99100
Negative regulation of MAPK pathway 34 9.16e-01 1.04e-02 0.99300
Acyl chain remodelling of PC 21 9.34e-01 -1.04e-02 0.99500
Hemostasis 465 7.04e-01 -1.04e-02 0.95900
PI-3K cascade:FGFR3 15 9.45e-01 -1.03e-02 0.99500
Vif-mediated degradation of APOBEC3G 35 9.17e-01 1.02e-02 0.99300
C-type lectin receptors (CLRs) 98 8.64e-01 -1.00e-02 0.97700
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 38 9.15e-01 1.00e-02 0.99300
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 64 8.90e-01 -9.96e-03 0.98500
Integrin signaling 23 9.35e-01 9.89e-03 0.99500
Diseases of signal transduction by growth factor receptors and second messengers 295 7.72e-01 9.84e-03 0.96200
Switching of origins to a post-replicative state 66 8.91e-01 -9.77e-03 0.98500
Metabolism 1538 5.36e-01 9.67e-03 0.94500
Regulation of RUNX2 expression and activity 50 9.13e-01 -8.97e-03 0.99300
L1CAM interactions 84 8.89e-01 8.85e-03 0.98500
CaM pathway 28 9.37e-01 -8.57e-03 0.99500
Calmodulin induced events 28 9.37e-01 -8.57e-03 0.99500
Toll-like Receptor Cascades 114 8.79e-01 8.26e-03 0.98100
FLT3 Signaling 218 8.37e-01 -8.12e-03 0.96800
TCF dependent signaling in response to WNT 132 8.74e-01 -8.01e-03 0.97800
The phototransduction cascade 24 9.46e-01 8.00e-03 0.99500
Leishmania infection 208 8.47e-01 -7.78e-03 0.97100
Adenylate cyclase activating pathway 10 9.66e-01 -7.77e-03 0.99500
Negative regulation of MET activity 14 9.60e-01 -7.74e-03 0.99500
RNA Polymerase III Transcription Initiation From Type 3 Promoter 19 9.54e-01 7.71e-03 0.99500
p53-Dependent G1 DNA Damage Response 46 9.29e-01 -7.60e-03 0.99500
p53-Dependent G1/S DNA damage checkpoint 46 9.29e-01 -7.60e-03 0.99500
SHC-mediated cascade:FGFR1 18 9.57e-01 7.40e-03 0.99500
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 34 9.40e-01 -7.40e-03 0.99500
p53-Independent DNA Damage Response 34 9.40e-01 -7.40e-03 0.99500
p53-Independent G1/S DNA damage checkpoint 34 9.40e-01 -7.40e-03 0.99500
Disease 1091 6.87e-01 7.35e-03 0.95900
PI3K events in ERBB2 signaling 13 9.64e-01 7.25e-03 0.99500
Reversible hydration of carbon dioxide 12 9.66e-01 -7.18e-03 0.99500
Thromboxane signalling through TP receptor 16 9.60e-01 -7.17e-03 0.99500
Abortive elongation of HIV-1 transcript in the absence of Tat 12 9.66e-01 -7.13e-03 0.99500
Downstream signaling of activated FGFR1 27 9.49e-01 7.12e-03 0.99500
Removal of the Flap Intermediate from the C-strand 12 9.66e-01 7.01e-03 0.99500
Signaling by NOTCH3 40 9.42e-01 -6.63e-03 0.99500
Metabolism of proteins 1369 6.89e-01 6.59e-03 0.95900
Regulation of activated PAK-2p34 by proteasome mediated degradation 34 9.47e-01 6.56e-03 0.99500
Nuclear Receptor transcription pathway 48 9.38e-01 -6.45e-03 0.99500
Adaptive Immune System 531 8.09e-01 -6.19e-03 0.96700
Regulation of TP53 Degradation 30 9.53e-01 6.16e-03 0.99500
WNT ligand biogenesis and trafficking 21 9.65e-01 5.54e-03 0.99500
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 28 9.60e-01 -5.51e-03 0.99500
RNA Polymerase II Pre-transcription Events 53 9.45e-01 -5.49e-03 0.99500
Signaling by FGFR4 31 9.58e-01 5.43e-03 0.99500
RNA Polymerase III Abortive And Retractive Initiation 27 9.61e-01 5.39e-03 0.99500
RNA Polymerase III Transcription 27 9.61e-01 5.39e-03 0.99500
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 30 9.60e-01 -5.32e-03 0.99500
Regulation of PTEN stability and activity 47 9.50e-01 -5.29e-03 0.99500
Cellular Senescence 103 9.27e-01 -5.24e-03 0.99500
Signaling by Nuclear Receptors 193 9.05e-01 -4.99e-03 0.98900
Asymmetric localization of PCP proteins 48 9.54e-01 -4.84e-03 0.99500
Ion channel transport 131 9.25e-01 -4.77e-03 0.99500
G-protein beta:gamma signalling 23 9.69e-01 -4.73e-03 0.99500
Netrin-1 signaling 41 9.59e-01 -4.63e-03 0.99500
ESR-mediated signaling 130 9.36e-01 4.07e-03 0.99500
Innate Immune System 741 8.54e-01 4.01e-03 0.97400
Signal Transduction 1944 7.80e-01 -3.94e-03 0.96200
RAF/MAP kinase cascade 205 9.23e-01 -3.92e-03 0.99500
Activation of GABAB receptors 34 9.68e-01 -3.92e-03 0.99500
GABA B receptor activation 34 9.68e-01 -3.92e-03 0.99500
Intra-Golgi traffic 34 9.69e-01 3.87e-03 0.99500
Fcgamma receptor (FCGR) dependent phagocytosis 76 9.55e-01 -3.74e-03 0.99500
HCMV Early Events 44 9.66e-01 3.74e-03 0.99500
Fatty acids 11 9.83e-01 -3.65e-03 1.00000
Rho GTPase cycle 118 9.46e-01 3.62e-03 0.99500
Membrane Trafficking 473 8.97e-01 -3.49e-03 0.98600
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 13 9.84e-01 3.28e-03 1.00000
Disorders of transmembrane transporters 133 9.48e-01 -3.26e-03 0.99500
Constitutive Signaling by AKT1 E17K in Cancer 22 9.79e-01 3.20e-03 1.00000
Post-translational protein modification 1001 8.67e-01 -3.17e-03 0.97800
Dectin-2 family 15 9.83e-01 -3.16e-03 1.00000
GPCR ligand binding 342 9.21e-01 -3.14e-03 0.99500
Synthesis of substrates in N-glycan biosythesis 52 9.69e-01 3.13e-03 0.99500
G1/S DNA Damage Checkpoints 47 9.71e-01 3.10e-03 0.99600
Transcriptional Regulation by VENTX 32 9.76e-01 3.04e-03 1.00000
Nervous system development 412 9.18e-01 2.96e-03 0.99400
Translesion synthesis by POLK 12 9.87e-01 -2.67e-03 1.00000
Negative regulation of FGFR2 signaling 26 9.82e-01 -2.52e-03 1.00000
Synthesis of DNA 88 9.68e-01 2.51e-03 0.99500
Signaling by NOTCH 140 9.60e-01 -2.43e-03 0.99500
Aflatoxin activation and detoxification 16 9.87e-01 2.36e-03 1.00000
Interleukin-10 signaling 33 9.82e-01 2.28e-03 1.00000
SCF-beta-TrCP mediated degradation of Emi1 38 9.81e-01 2.18e-03 1.00000
Inactivation, recovery and regulation of the phototransduction cascade 23 9.86e-01 2.14e-03 1.00000
Synthesis of PIPs at the Golgi membrane 14 9.91e-01 1.70e-03 1.00000
Deposition of new CENPA-containing nucleosomes at the centromere 16 9.91e-01 -1.66e-03 1.00000
Nucleosome assembly 16 9.91e-01 -1.66e-03 1.00000
Transcriptional regulation by RUNX3 76 9.80e-01 1.64e-03 1.00000
Signaling by Receptor Tyrosine Kinases 392 9.57e-01 -1.60e-03 0.99500
Removal of the Flap Intermediate 11 9.94e-01 -1.37e-03 1.00000
FCERI mediated NF-kB activation 55 9.87e-01 -1.29e-03 1.00000
Pyruvate metabolism and Citric Acid (TCA) cycle 39 9.90e-01 1.17e-03 1.00000
Ras activation upon Ca2+ influx through NMDA receptor 16 9.94e-01 1.14e-03 1.00000
G beta:gamma signalling through CDC42 13 9.95e-01 1.10e-03 1.00000
Cilium Assembly 148 9.83e-01 1.01e-03 1.00000
Aquaporin-mediated transport 42 9.92e-01 -8.86e-04 1.00000
Synthesis, secretion, and deacylation of Ghrelin 14 9.96e-01 -8.44e-04 1.00000
MAPK1/MAPK3 signaling 210 9.92e-01 -4.24e-04 1.00000
FRS-mediated FGFR1 signaling 19 9.97e-01 4.21e-04 1.00000
Axon guidance 391 9.89e-01 -3.98e-04 1.00000
Interferon gamma signaling 57 9.96e-01 3.89e-04 1.00000
Vasopressin regulates renal water homeostasis via Aquaporins 34 9.97e-01 -3.18e-04 1.00000
Developmental Biology 716 9.90e-01 2.81e-04 1.00000
Regulation of TP53 Expression and Degradation 31 9.99e-01 1.37e-04 1.00000
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 55 9.99e-01 1.27e-04 1.00000
Autophagy 96 9.99e-01 -8.76e-05 1.00000
Cell-extracellular matrix interactions 14 1.00e+00 -7.72e-05 1.00000
Negative regulation of NOTCH4 signaling 38 1.00e+00 4.18e-05 1.00000


Detailed Gene set reports



TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation
1184
set TRAF6 mediated IRF7 activation
setSize 28
pANOVA 1.26e-06
s.dist 0.529
p.adjustANOVA 0.00168



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRF7 6525
IFNA1 6455
IFNA10 6455
IFNA14 6455
IFNA16 6455
IFNA17 6455
IFNA2 6455
IFNA21 6455
IFNA4 6455
IFNA5 6455
IFNA6 6455
IFNA7 6455
IFNA8 6455
TRIM25 6238
SIKE1 5591
CREBBP 4905
MAVS 4637
EP300 4577
TBK1 3656
TANK 3276

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRF7 6525
IFNA1 6455
IFNA10 6455
IFNA14 6455
IFNA16 6455
IFNA17 6455
IFNA2 6455
IFNA21 6455
IFNA4 6455
IFNA5 6455
IFNA6 6455
IFNA7 6455
IFNA8 6455
TRIM25 6238
SIKE1 5591
CREBBP 4905
MAVS 4637
EP300 4577
TBK1 3656
TANK 3276
IFIH1 2048
RNF135 1160
IRF3 817
TRAF2 -232
TRAF6 -412
IKBKE -2494
DDX58 -4737
IFNB1 -5873


Condensation of Prophase Chromosomes

Condensation of Prophase Chromosomes
201
set Condensation of Prophase Chromosomes
setSize 10
pANOVA 0.00677
s.dist 0.495
p.adjustANOVA 0.637



Top enriched genes

Top 20 genes
GeneID Gene Rank
PHF8 6782
MCPH1 5957
CDK1 5332
RB1 5239
SMC4 4810
CCNB1 4806
H2AFX 3215
SET 2312
NCAPG2 6
NCAPH2 -2548

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PHF8 6782
MCPH1 5957
CDK1 5332
RB1 5239
SMC4 4810
CCNB1 4806
H2AFX 3215
SET 2312
NCAPG2 6
NCAPH2 -2548


Regulation of IFNA signaling

Regulation of IFNA signaling
933
set Regulation of IFNA signaling
setSize 23
pANOVA 0.000121
s.dist 0.463
p.adjustANOVA 0.0808



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA1 6455.0
IFNA10 6455.0
IFNA14 6455.0
IFNA16 6455.0
IFNA17 6455.0
IFNA2 6455.0
IFNA21 6455.0
IFNA4 6455.0
IFNA5 6455.0
IFNA6 6455.0
IFNA7 6455.0
IFNA8 6455.0
PTPN1 5377.0
IFNAR2 4782.0
SOCS3 4354.0
USP18 1630.5
STAT1 1477.0
IFNAR1 574.0
TYK2 -1243.0
JAK1 -2079.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA1 6455.0
IFNA10 6455.0
IFNA14 6455.0
IFNA16 6455.0
IFNA17 6455.0
IFNA2 6455.0
IFNA21 6455.0
IFNA4 6455.0
IFNA5 6455.0
IFNA6 6455.0
IFNA7 6455.0
IFNA8 6455.0
PTPN1 5377.0
IFNAR2 4782.0
SOCS3 4354.0
USP18 1630.5
STAT1 1477.0
IFNAR1 574.0
TYK2 -1243.0
JAK1 -2079.0
PTPN11 -2745.0
IFNB1 -5873.0
PTPN6 -6221.0


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1303
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 11
pANOVA 0.00908
s.dist 0.454
p.adjustANOVA 0.637



Top enriched genes

Top 20 genes
GeneID Gene Rank
FADS2 6603
ACOT8 6366
ELOVL2 5022
ELOVL3 4709
HSD17B4 4554
SCP2 4022
FADS1 3739
ELOVL5 1053
ELOVL1 633
ACOX1 459
ACSL1 -730

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FADS2 6603
ACOT8 6366
ELOVL2 5022
ELOVL3 4709
HSD17B4 4554
SCP2 4022
FADS1 3739
ELOVL5 1053
ELOVL1 633
ACOX1 459
ACSL1 -730


alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1304
set alpha-linolenic acid (ALA) metabolism
setSize 11
pANOVA 0.00908
s.dist 0.454
p.adjustANOVA 0.637



Top enriched genes

Top 20 genes
GeneID Gene Rank
FADS2 6603
ACOT8 6366
ELOVL2 5022
ELOVL3 4709
HSD17B4 4554
SCP2 4022
FADS1 3739
ELOVL5 1053
ELOVL1 633
ACOX1 459
ACSL1 -730

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FADS2 6603
ACOT8 6366
ELOVL2 5022
ELOVL3 4709
HSD17B4 4554
SCP2 4022
FADS1 3739
ELOVL5 1053
ELOVL1 633
ACOX1 459
ACSL1 -730


Heme degradation

Heme degradation
494
set Heme degradation
setSize 15
pANOVA 0.00232
s.dist 0.454
p.adjustANOVA 0.362



Top enriched genes

Top 20 genes
GeneID Gene Rank
HMOX2 6853.0
ABCG2 6672.0
ABCC1 6183.0
GSTA1 5192.5
SLCO1B1 4741.0
SLCO1B3 4741.0
BLVRA 4703.0
ABCC2 3920.0
SLCO2B1 3857.0
ALB 3645.0
UGT1A4 2922.0
BLVRB 926.0
HMOX1 -968.0
GUSB -1232.0
FABP1 -2505.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HMOX2 6853.0
ABCG2 6672.0
ABCC1 6183.0
GSTA1 5192.5
SLCO1B1 4741.0
SLCO1B3 4741.0
BLVRA 4703.0
ABCC2 3920.0
SLCO2B1 3857.0
ALB 3645.0
UGT1A4 2922.0
BLVRB 926.0
HMOX1 -968.0
GUSB -1232.0
FABP1 -2505.0


E2F mediated regulation of DNA replication

E2F mediated regulation of DNA replication
311
set E2F mediated regulation of DNA replication
setSize 18
pANOVA 0.00109
s.dist 0.445
p.adjustANOVA 0.292



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1A 6383.0
ORC2 6251.0
PPP2R1B 5533.0
E2F1 5502.0
CDK1 5332.0
RB1 5239.0
ORC1 4978.0
CCNB1 4806.0
PPP2CA 4097.0
POLA2 3942.0
TFDP2 3548.0
POLA1 2821.0
ORC3 2699.0
ORC4 2545.0
PRIM2 1786.0
PPP2CB 787.0
PRIM1 -2478.0
TFDP1 -5401.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1A 6383.0
ORC2 6251.0
PPP2R1B 5533.0
E2F1 5502.0
CDK1 5332.0
RB1 5239.0
ORC1 4978.0
CCNB1 4806.0
PPP2CA 4097.0
POLA2 3942.0
TFDP2 3548.0
POLA1 2821.0
ORC3 2699.0
ORC4 2545.0
PRIM2 1786.0
PPP2CB 787.0
PRIM1 -2478.0
TFDP1 -5401.5


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
1295
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 12
pANOVA 0.0129
s.dist 0.415
p.adjustANOVA 0.748



Top enriched genes

Top 20 genes
GeneID Gene Rank
ROR1 7079
CLTC 6403
AP2M1 6005
ROR2 5359
AP2A2 3939
FZD2 3036
FZD5 2992
AP2S1 2697
CLTB 2691
WNT5A 277
AP2A1 -1653
CLTA -2393

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ROR1 7079
CLTC 6403
AP2M1 6005
ROR2 5359
AP2A2 3939
FZD2 3036
FZD5 2992
AP2S1 2697
CLTB 2691
WNT5A 277
AP2A1 -1653
CLTA -2393


Regulation of signaling by NODAL

Regulation of signaling by NODAL
974
set Regulation of signaling by NODAL
setSize 10
pANOVA 0.0441
s.dist -0.368
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
DAND5 -6416.0
ACVR1C -6058.0
TDGF1 -5972.0
ACVR2A -3417.0
CER1 -3309.0
ACVR2B -2649.0
NODAL -2480.0
LEFTY1 1375.5
LEFTY2 1375.5
ACVR1B 3631.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DAND5 -6416.0
ACVR1C -6058.0
TDGF1 -5972.0
ACVR2A -3417.0
CER1 -3309.0
ACVR2B -2649.0
NODAL -2480.0
LEFTY1 1375.5
LEFTY2 1375.5
ACVR1B 3631.0


Regulation of PTEN mRNA translation

Regulation of PTEN mRNA translation
940
set Regulation of PTEN mRNA translation
setSize 11
pANOVA 0.0348
s.dist 0.368
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTEN 7020
MIR214 6581
CNOT6L 6050
AGO2 5601
AGO4 4382
MOV10 3708
AGO3 1416
TNRC6B 1372
AGO1 1256
TNRC6C -2939
MIR26A1 -4639

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTEN 7020
MIR214 6581
CNOT6L 6050
AGO2 5601
AGO4 4382
MOV10 3708
AGO3 1416
TNRC6B 1372
AGO1 1256
TNRC6C -2939
MIR26A1 -4639


Inhibition of replication initiation of damaged DNA by RB1/E2F1

Inhibition of replication initiation of damaged DNA by RB1/E2F1
523
set Inhibition of replication initiation of damaged DNA by RB1/E2F1
setSize 12
pANOVA 0.0316
s.dist 0.358
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1A 6383.0
PPP2R1B 5533.0
E2F1 5502.0
RB1 5239.0
PPP2CA 4097.0
POLA2 3942.0
TFDP2 3548.0
POLA1 2821.0
PRIM2 1786.0
PPP2CB 787.0
PRIM1 -2478.0
TFDP1 -5401.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1A 6383.0
PPP2R1B 5533.0
E2F1 5502.0
RB1 5239.0
PPP2CA 4097.0
POLA2 3942.0
TFDP2 3548.0
POLA1 2821.0
PRIM2 1786.0
PPP2CB 787.0
PRIM1 -2478.0
TFDP1 -5401.5


Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization
468
set Golgi Cisternae Pericentriolar Stack Reorganization
setSize 11
pANOVA 0.0417
s.dist 0.355
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK1 5777
USO1 5407
CDK1 5332
CCNB1 4806
RAB2A 3107
BLZF1 2791
RAB1A 2718
MAPK3 932
GORASP2 19
GOLGA2 -846
RAB1B -1220

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 5777
USO1 5407
CDK1 5332
CCNB1 4806
RAB2A 3107
BLZF1 2791
RAB1A 2718
MAPK3 932
GORASP2 19
GOLGA2 -846
RAB1B -1220


Tandem pore domain potassium channels

Tandem pore domain potassium channels
1190
set Tandem pore domain potassium channels
setSize 11
pANOVA 0.0426
s.dist 0.353
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK3 4958
KCNK1 4901
KCNK13 4750
KCNK9 4546
KCNK16 2339
KCNK18 2253
KCNK2 2151
KCNK6 1494
KCNK7 1039
KCNK4 477
KCNK10 -204

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK3 4958
KCNK1 4901
KCNK13 4750
KCNK9 4546
KCNK16 2339
KCNK18 2253
KCNK2 2151
KCNK6 1494
KCNK7 1039
KCNK4 477
KCNK10 -204


Scavenging of heme from plasma

Scavenging of heme from plasma
1034
set Scavenging of heme from plasma
setSize 10
pANOVA 0.0539
s.dist -0.352
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHA1 -6546.5
IGHA2 -6546.5
AMBP -5240.0
LRP1 -4439.0
HP -3698.5
HPR -3698.5
APOL1 -3470.5
APOA1 273.0
ALB 3645.0
HPX 6888.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHA1 -6546.5
IGHA2 -6546.5
AMBP -5240.0
LRP1 -4439.0
HP -3698.5
HPR -3698.5
APOL1 -3470.5
APOA1 273.0
ALB 3645.0
HPX 6888.0


Metabolism of porphyrins

Metabolism of porphyrins
632
set Metabolism of porphyrins
setSize 25
pANOVA 0.00245
s.dist 0.35
p.adjustANOVA 0.362



Top enriched genes

Top 20 genes
GeneID Gene Rank
FECH 7038.0
HMOX2 6853.0
UROD 6775.0
ABCG2 6672.0
ABCC1 6183.0
HMBS 5775.0
GSTA1 5192.5
SLCO1B1 4741.0
SLCO1B3 4741.0
BLVRA 4703.0
PPOX 4263.0
ABCC2 3920.0
SLCO2B1 3857.0
ALB 3645.0
CPOX 2932.0
UGT1A4 2922.0
ALAS2 2270.0
BLVRB 926.0
HMOX1 -968.0
GUSB -1232.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FECH 7038.0
HMOX2 6853.0
UROD 6775.0
ABCG2 6672.0
ABCC1 6183.0
HMBS 5775.0
GSTA1 5192.5
SLCO1B1 4741.0
SLCO1B3 4741.0
BLVRA 4703.0
PPOX 4263.0
ABCC2 3920.0
SLCO2B1 3857.0
ALB 3645.0
CPOX 2932.0
UGT1A4 2922.0
ALAS2 2270.0
BLVRB 926.0
HMOX1 -968.0
GUSB -1232.0
COX15 -1348.0
ALAS1 -2042.0
FABP1 -2505.0
ALAD -4717.0
UROS -5932.0


Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
1268
set Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
setSize 11
pANOVA 0.0514
s.dist 0.339
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
DCP2 6773
YWHAB 6616
EXOSC2 6470
EXOSC3 6265
EXOSC9 5962
TNPO1 4077
EXOSC8 3970
DCP1A 2988
EXOSC7 -3933
XRN1 -4965
DIS3 -6579

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DCP2 6773
YWHAB 6616
EXOSC2 6470
EXOSC3 6265
EXOSC9 5962
TNPO1 4077
EXOSC8 3970
DCP1A 2988
EXOSC7 -3933
XRN1 -4965
DIS3 -6579


FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes
371
set FOXO-mediated transcription of cell death genes
setSize 13
pANOVA 0.0369
s.dist 0.334
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
NFYC 6760
CREBBP 4905
EP300 4577
CITED2 4485
FOXO3 3593
FOXO4 3114
STK11 3052
NFYA 2597
NFYB 2349
BCL2L11 1954
BCL6 1435
FASLG -2643
PINK1 -3960

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NFYC 6760
CREBBP 4905
EP300 4577
CITED2 4485
FOXO3 3593
FOXO4 3114
STK11 3052
NFYA 2597
NFYB 2349
BCL2L11 1954
BCL6 1435
FASLG -2643
PINK1 -3960


Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
183
set Citric acid cycle (TCA cycle)
setSize 15
pANOVA 0.0272
s.dist 0.329
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
NNT 6718
SUCLA2 5881
DLST 5763
DLD 5656
ME2 5436
ME3 4994
SDHA 4617
IDH3B 3491
SUCLG1 1999
ACO2 485
SDHB -22
IDH3G -294
IDH2 -817
FH -1462
CS -5774

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NNT 6718
SUCLA2 5881
DLST 5763
DLD 5656
ME2 5436
ME3 4994
SDHA 4617
IDH3B 3491
SUCLG1 1999
ACO2 485
SDHB -22
IDH3G -294
IDH2 -817
FH -1462
CS -5774


Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition
216
set Cyclin A/B1/B2 associated events during G2/M transition
setSize 13
pANOVA 0.0404
s.dist 0.328
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1A 6383
PPP2R1B 5533
CDK1 5332
XPO1 5255
CCNB1 4806
CCNA1 4136
PPP2CA 4097
CDC25A 3589
CCNA2 3048
PPP2CB 787
CDC25B -2367
CCNH -2608
FOXM1 -6310

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1A 6383
PPP2R1B 5533
CDK1 5332
XPO1 5255
CCNB1 4806
CCNA1 4136
PPP2CA 4097
CDC25A 3589
CCNA2 3048
PPP2CB 787
CDC25B -2367
CCNH -2608
FOXM1 -6310


Nucleotide-like (purinergic) receptors

Nucleotide-like (purinergic) receptors
739
set Nucleotide-like (purinergic) receptors
setSize 11
pANOVA 0.0613
s.dist -0.326
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADORA2B -6681
ADORA2A -5578
P2RY6 -5049
P2RY12 -4899
GPR17 -4380
P2RY13 -4278
P2RY1 -3476
P2RY4 -2565
P2RY14 2440
P2RY2 4310
ADORA1 7041

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADORA2B -6681
ADORA2A -5578
P2RY6 -5049
P2RY12 -4899
GPR17 -4380
P2RY13 -4278
P2RY1 -3476
P2RY4 -2565
P2RY14 2440
P2RY2 4310
ADORA1 7041


Phase 4 - resting membrane potential

Phase 4 - resting membrane potential
795
set Phase 4 - resting membrane potential
setSize 17
pANOVA 0.0201
s.dist 0.326
p.adjustANOVA 0.808



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK12 6813
KCNK5 6472
KCNJ4 5785
KCNJ12 5102
KCNK3 4958
KCNK1 4901
KCNK13 4750
KCNK9 4546
KCNK16 2339
KCNK18 2253
KCNK2 2151
KCNK6 1494
KCNK7 1039
KCNK4 477
KCNK10 -204
KCNJ14 -5443
KCNK15 -6315

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK12 6813
KCNK5 6472
KCNJ4 5785
KCNJ12 5102
KCNK3 4958
KCNK1 4901
KCNK13 4750
KCNK9 4546
KCNK16 2339
KCNK18 2253
KCNK2 2151
KCNK6 1494
KCNK7 1039
KCNK4 477
KCNK10 -204
KCNJ14 -5443
KCNK15 -6315


Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade
284
set Diseases associated with the TLR signaling cascade
setSize 18
pANOVA 0.0189
s.dist -0.32
p.adjustANOVA 0.808



Top enriched genes

Top 20 genes
GeneID Gene Rank
LY96 -5820
TRAF3 -5705
TLR2 -5525
CHUK -5160
IKBKB -4573
TLR5 -4539
TLR6 -4458
NFKB2 -2503
CD36 -2327
CD14 -1831
TLR1 -1546
RELA -1430
TIRAP -787
IKBKG -291
NFKB1 -49
TLR3 2029
NFKBIA 3567
TICAM1 3918

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LY96 -5820
TRAF3 -5705
TLR2 -5525
CHUK -5160
IKBKB -4573
TLR5 -4539
TLR6 -4458
NFKB2 -2503
CD36 -2327
CD14 -1831
TLR1 -1546
RELA -1430
TIRAP -787
IKBKG -291
NFKB1 -49
TLR3 2029
NFKBIA 3567
TICAM1 3918


Diseases of Immune System

Diseases of Immune System
287
set Diseases of Immune System
setSize 18
pANOVA 0.0189
s.dist -0.32
p.adjustANOVA 0.808



Top enriched genes

Top 20 genes
GeneID Gene Rank
LY96 -5820
TRAF3 -5705
TLR2 -5525
CHUK -5160
IKBKB -4573
TLR5 -4539
TLR6 -4458
NFKB2 -2503
CD36 -2327
CD14 -1831
TLR1 -1546
RELA -1430
TIRAP -787
IKBKG -291
NFKB1 -49
TLR3 2029
NFKBIA 3567
TICAM1 3918

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LY96 -5820
TRAF3 -5705
TLR2 -5525
CHUK -5160
IKBKB -4573
TLR5 -4539
TLR6 -4458
NFKB2 -2503
CD36 -2327
CD14 -1831
TLR1 -1546
RELA -1430
TIRAP -787
IKBKG -291
NFKB1 -49
TLR3 2029
NFKBIA 3567
TICAM1 3918


Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
693
set Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
setSize 16
pANOVA 0.0282
s.dist 0.317
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
B2M 7065
AP2M1 6005
CD28 5298
AP1M2 4762
AP1G1 4230
AP1S2 4179
PACS1 4002
AP2A2 3939
CD4 3343
AP2S1 2697
LCK 2589
AP1B1 711
AP1S3 -1419
AP2A1 -1653
AP1S1 -2670
AP1M1 -5358

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B2M 7065
AP2M1 6005
CD28 5298
AP1M2 4762
AP1G1 4230
AP1S2 4179
PACS1 4002
AP2A2 3939
CD4 3343
AP2S1 2697
LCK 2589
AP1B1 711
AP1S3 -1419
AP2A1 -1653
AP1S1 -2670
AP1M1 -5358


Eicosanoid ligand-binding receptors

Eicosanoid ligand-binding receptors
331
set Eicosanoid ligand-binding receptors
setSize 10
pANOVA 0.0844
s.dist -0.315
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTGER3 -6088
TBXA2R -5179
PTGDR2 -5042
GPR17 -4380
LTB4R -3049
PTGIR -2311
PTGFR -1107
PTGER1 321
LTB4R2 3254
PTGER4 3302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGER3 -6088
TBXA2R -5179
PTGDR2 -5042
GPR17 -4380
LTB4R -3049
PTGIR -2311
PTGFR -1107
PTGER1 321
LTB4R2 3254
PTGER4 3302


Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
24
set Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
setSize 13
pANOVA 0.0513
s.dist 0.312
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1B 5654.0
E2F1 5502.0
RB1 5239.0
E2F2 4129.0
CDKN1A 4027.0
CDK4 3960.0
TFDP2 3548.0
E2F3 2654.0
CCND3 2174.0
CCND1 1432.0
CDKN1C 1212.0
CCNE1 -3898.0
TFDP1 -5401.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1B 5654.0
E2F1 5502.0
RB1 5239.0
E2F2 4129.0
CDKN1A 4027.0
CDK4 3960.0
TFDP2 3548.0
E2F3 2654.0
CCND3 2174.0
CCND1 1432.0
CDKN1C 1212.0
CCNE1 -3898.0
TFDP1 -5401.5


Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
256
set Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
setSize 13
pANOVA 0.0513
s.dist 0.312
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1B 5654.0
E2F1 5502.0
RB1 5239.0
E2F2 4129.0
CDKN1A 4027.0
CDK4 3960.0
TFDP2 3548.0
E2F3 2654.0
CCND3 2174.0
CCND1 1432.0
CDKN1C 1212.0
CCNE1 -3898.0
TFDP1 -5401.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1B 5654.0
E2F1 5502.0
RB1 5239.0
E2F2 4129.0
CDKN1A 4027.0
CDK4 3960.0
TFDP2 3548.0
E2F3 2654.0
CCND3 2174.0
CCND1 1432.0
CDKN1C 1212.0
CCNE1 -3898.0
TFDP1 -5401.5


TP53 Regulates Transcription of Death Receptors and Ligands

TP53 Regulates Transcription of Death Receptors and Ligands
1177
set TP53 Regulates Transcription of Death Receptors and Ligands
setSize 10
pANOVA 0.0887
s.dist 0.311
p.adjustANOVA 0.853



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGFBP3 6562.0
TP63 5421.0
TNFRSF10A 3418.5
TNFRSF10B 3418.5
TNFRSF10C 3418.5
TNFRSF10D 3418.5
PPP1R13B 2560.0
TP73 365.0
TP53 340.0
TMEM219 -5750.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGFBP3 6562.0
TP63 5421.0
TNFRSF10A 3418.5
TNFRSF10B 3418.5
TNFRSF10C 3418.5
TNFRSF10D 3418.5
PPP1R13B 2560.0
TP73 365.0
TP53 340.0
TMEM219 -5750.0


HS-GAG biosynthesis

HS-GAG biosynthesis
485
set HS-GAG biosynthesis
setSize 22
pANOVA 0.0124
s.dist -0.308
p.adjustANOVA 0.748



Top enriched genes

Top 20 genes
GeneID Gene Rank
HS3ST5 -6763
HS3ST1 -5600
GPC3 -5370
EXT2 -5263
SDC4 -5131
HSPG2 -4993
GPC6 -4732
NDST4 -4669
GPC1 -4511
NDST2 -4223
HS3ST2 -3484
NDST1 -3408
AGRN -3290
NDST3 -2290
SDC3 -1679
HS6ST3 -1533
SLC35D2 702
EXT1 1077
GLCE 3307
HS6ST1 5813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HS3ST5 -6763
HS3ST1 -5600
GPC3 -5370
EXT2 -5263
SDC4 -5131
HSPG2 -4993
GPC6 -4732
NDST4 -4669
GPC1 -4511
NDST2 -4223
HS3ST2 -3484
NDST1 -3408
AGRN -3290
NDST3 -2290
SDC3 -1679
HS6ST3 -1533
SLC35D2 702
EXT1 1077
GLCE 3307
HS6ST1 5813
GPC2 6036
GPC5 6503


Defective EXT1 causes exostoses 1, TRPS2 and CHDS

Defective EXT1 causes exostoses 1, TRPS2 and CHDS
251
set Defective EXT1 causes exostoses 1, TRPS2 and CHDS
setSize 11
pANOVA 0.0821
s.dist -0.303
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
GPC3 -5370
EXT2 -5263
SDC4 -5131
HSPG2 -4993
GPC6 -4732
GPC1 -4511
AGRN -3290
SDC3 -1679
EXT1 1077
GPC2 6036
GPC5 6503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPC3 -5370
EXT2 -5263
SDC4 -5131
HSPG2 -4993
GPC6 -4732
GPC1 -4511
AGRN -3290
SDC3 -1679
EXT1 1077
GPC2 6036
GPC5 6503


Defective EXT2 causes exostoses 2

Defective EXT2 causes exostoses 2
252
set Defective EXT2 causes exostoses 2
setSize 11
pANOVA 0.0821
s.dist -0.303
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
GPC3 -5370
EXT2 -5263
SDC4 -5131
HSPG2 -4993
GPC6 -4732
GPC1 -4511
AGRN -3290
SDC3 -1679
EXT1 1077
GPC2 6036
GPC5 6503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPC3 -5370
EXT2 -5263
SDC4 -5131
HSPG2 -4993
GPC6 -4732
GPC1 -4511
AGRN -3290
SDC3 -1679
EXT1 1077
GPC2 6036
GPC5 6503


Regulation of TP53 Activity through Methylation

Regulation of TP53 Activity through Methylation
951
set Regulation of TP53 Activity through Methylation
setSize 11
pANOVA 0.0823
s.dist -0.303
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBA52 -5940
SMYD2 -5861
PRMT5 -4537
MDM2 -4532
ATM -4492
L3MBTL1 -3551
EHMT2 -2103
TP53 340
MDM4 1353
EHMT1 3409
EP300 4577

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBA52 -5940
SMYD2 -5861
PRMT5 -4537
MDM2 -4532
ATM -4492
L3MBTL1 -3551
EHMT2 -2103
TP53 340
MDM4 1353
EHMT1 3409
EP300 4577


Diseases of DNA repair

Diseases of DNA repair
286
set Diseases of DNA repair
setSize 10
pANOVA 0.109
s.dist 0.293
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEIL3 6805
PMS2 5219
MUTYH 4387
MSH6 4160
MSH3 3478
MLH1 3139
NTHL1 2128
MSH2 -2420
OGG1 -2458
NEIL1 -2521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEIL3 6805
PMS2 5219
MUTYH 4387
MSH6 4160
MSH3 3478
MLH1 3139
NTHL1 2128
MSH2 -2420
OGG1 -2458
NEIL1 -2521


The role of Nef in HIV-1 replication and disease pathogenesis

The role of Nef in HIV-1 replication and disease pathogenesis
1204
set The role of Nef in HIV-1 replication and disease pathogenesis
setSize 23
pANOVA 0.0155
s.dist 0.291
p.adjustANOVA 0.768



Top enriched genes

Top 20 genes
GeneID Gene Rank
B2M 7065
PAK2 6878
AP2M1 6005
RAC1 5939
CD28 5298
AP1M2 4762
AP1G1 4230
AP1S2 4179
PACS1 4002
AP2A2 3939
ELMO1 3914
FYN 3558
CD4 3343
AP2S1 2697
LCK 2589
AP1B1 711
HCK -525
AP1S3 -1419
AP2A1 -1653
DOCK2 -2344

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B2M 7065
PAK2 6878
AP2M1 6005
RAC1 5939
CD28 5298
AP1M2 4762
AP1G1 4230
AP1S2 4179
PACS1 4002
AP2A2 3939
ELMO1 3914
FYN 3558
CD4 3343
AP2S1 2697
LCK 2589
AP1B1 711
HCK -525
AP1S3 -1419
AP2A1 -1653
DOCK2 -2344
AP1S1 -2670
CD247 -4994
AP1M1 -5358


ER Quality Control Compartment (ERQC)

ER Quality Control Compartment (ERQC)
321
set ER Quality Control Compartment (ERQC)
setSize 12
pANOVA 0.0814
s.dist -0.291
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
EDEM3 -6718
SEL1L -6254
UGGT2 -5986
UBA52 -5940
EDEM2 -4657
TRIM13 -4046
AMFR -3248
UGGT1 -3042
OS9 1291
MAN1B1 3940
RNF139 5561
SYVN1 6822

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EDEM3 -6718
SEL1L -6254
UGGT2 -5986
UBA52 -5940
EDEM2 -4657
TRIM13 -4046
AMFR -3248
UGGT1 -3042
OS9 1291
MAN1B1 3940
RNF139 5561
SYVN1 6822


Synthesis of PC

Synthesis of PC
1143
set Synthesis of PC
setSize 20
pANOVA 0.025
s.dist 0.29
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCYT1B 7023
LPIN1 6540
LPIN3 6297
ABHD3 5426
SLC44A5 5174
SLC44A2 5000
CSNK2A2 4151
LPCAT1 3642
PHOSPHO1 3138
CHPT1 3054
STARD7 2053
SLC44A4 1768
SLC44A1 1695
ACHE 1163
MFSD2A 943
PEMT 651
LPIN2 233
CHKA -3142
STARD10 -4912
PCTP -6558

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCYT1B 7023
LPIN1 6540
LPIN3 6297
ABHD3 5426
SLC44A5 5174
SLC44A2 5000
CSNK2A2 4151
LPCAT1 3642
PHOSPHO1 3138
CHPT1 3054
STARD7 2053
SLC44A4 1768
SLC44A1 1695
ACHE 1163
MFSD2A 943
PEMT 651
LPIN2 233
CHKA -3142
STARD10 -4912
PCTP -6558


Defective B4GALT7 causes EDS, progeroid type

Defective B4GALT7 causes EDS, progeroid type
248
set Defective B4GALT7 causes EDS, progeroid type
setSize 15
pANOVA 0.0546
s.dist -0.287
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSPG4 -6553
B4GALT7 -6313
GPC3 -5370
DCN -5348
SDC4 -5131
HSPG2 -4993
GPC6 -4732
GPC1 -4511
AGRN -3290
SDC3 -1679
VCAN -1017
BGN 2075
GPC2 6036
GPC5 6503
CSPG5 6884

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSPG4 -6553
B4GALT7 -6313
GPC3 -5370
DCN -5348
SDC4 -5131
HSPG2 -4993
GPC6 -4732
GPC1 -4511
AGRN -3290
SDC3 -1679
VCAN -1017
BGN 2075
GPC2 6036
GPC5 6503
CSPG5 6884


Norepinephrine Neurotransmitter Release Cycle

Norepinephrine Neurotransmitter Release Cycle
724
set Norepinephrine Neurotransmitter Release Cycle
setSize 12
pANOVA 0.0878
s.dist -0.285
p.adjustANOVA 0.853



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC22A2 -6321
RIMS1 -5618
PPFIA4 -4545
SYT1 -4124
STX1A -3905
UNC13B -3618
PPFIA3 -2561
SLC22A1 -1671
PPFIA1 -245
STXBP1 757
RAB3A 3959
VAMP2 6110

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC22A2 -6321
RIMS1 -5618
PPFIA4 -4545
SYT1 -4124
STX1A -3905
UNC13B -3618
PPFIA3 -2561
SLC22A1 -1671
PPFIA1 -245
STXBP1 757
RAB3A 3959
VAMP2 6110


Smooth Muscle Contraction

Smooth Muscle Contraction
1126
set Smooth Muscle Contraction
setSize 29
pANOVA 0.00828
s.dist 0.283
p.adjustANOVA 0.637



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYH11 7060
PAK2 6878
SORBS1 6816
ACTA2 5686
ACTG2 5570
LMOD1 4490
CAV3 4358
MYL12A 4300
MYL7 4225
TLN1 4158
MYLK 3664
MYL6 3649
ANXA6 3223
ITGA1 3091
MYL10 2982
ANXA2 2930
TPM3 2346
TPM1 1855
GUCY1A3 1731
DYSF 1613

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYH11 7060
PAK2 6878
SORBS1 6816
ACTA2 5686
ACTG2 5570
LMOD1 4490
CAV3 4358
MYL12A 4300
MYL7 4225
TLN1 4158
MYLK 3664
MYL6 3649
ANXA6 3223
ITGA1 3091
MYL10 2982
ANXA2 2930
TPM3 2346
TPM1 1855
GUCY1A3 1731
DYSF 1613
CALM1 1300
ITGB5 -573
PXN -582
MYL12B -1451
TPM2 -1516
GUCY1B3 -3166
ANXA1 -3255
MYL9 -3856
CALD1 -5956


Heme biosynthesis

Heme biosynthesis
493
set Heme biosynthesis
setSize 12
pANOVA 0.0916
s.dist 0.281
p.adjustANOVA 0.853



Top enriched genes

Top 20 genes
GeneID Gene Rank
FECH 7038
UROD 6775
ABCG2 6672
HMBS 5775
PPOX 4263
ALB 3645
CPOX 2932
ALAS2 2270
COX15 -1348
ALAS1 -2042
ALAD -4717
UROS -5932

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FECH 7038
UROD 6775
ABCG2 6672
HMBS 5775
PPOX 4263
ALB 3645
CPOX 2932
ALAS2 2270
COX15 -1348
ALAS1 -2042
ALAD -4717
UROS -5932


Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation
45
set Activation of PPARGC1A (PGC-1alpha) by phosphorylation
setSize 10
pANOVA 0.124
s.dist -0.281
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAB1 -5640
PPARGC1A -4684
PRKAG1 -4110
PRKAG2 -4038
MAPK11 -2706
PRKAG3 -2092
PRKAA2 -2065
MAPK14 1261
MAPK12 2975
PRKAB2 3217

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAB1 -5640
PPARGC1A -4684
PRKAG1 -4110
PRKAG2 -4038
MAPK11 -2706
PRKAG3 -2092
PRKAA2 -2065
MAPK14 1261
MAPK12 2975
PRKAB2 3217


Interferon alpha/beta signaling

Interferon alpha/beta signaling
542
set Interferon alpha/beta signaling
setSize 50
pANOVA 0.000644
s.dist 0.279
p.adjustANOVA 0.222



Top enriched genes

Top 20 genes
GeneID Gene Rank
OAS1 6942
IRF7 6525
IFNA1 6455
IFNA10 6455
IFNA14 6455
IFNA16 6455
IFNA17 6455
IFNA2 6455
IFNA21 6455
IFNA4 6455
IFNA5 6455
IFNA6 6455
IFNA7 6455
IFNA8 6455
SAMHD1 6247
PTPN1 5377
MX1 4918
IFNAR2 4782
PSMB8 4384
SOCS3 4354

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OAS1 6942.0
IRF7 6525.0
IFNA1 6455.0
IFNA10 6455.0
IFNA14 6455.0
IFNA16 6455.0
IFNA17 6455.0
IFNA2 6455.0
IFNA21 6455.0
IFNA4 6455.0
IFNA5 6455.0
IFNA6 6455.0
IFNA7 6455.0
IFNA8 6455.0
SAMHD1 6247.0
PTPN1 5377.0
MX1 4918.0
IFNAR2 4782.0
PSMB8 4384.0
SOCS3 4354.0
RSAD2 3229.0
IRF9 3134.0
OAS2 3000.0
IFITM1 2641.0
IFITM2 2641.0
IFITM3 2641.0
BST2 2518.0
IRF1 2026.0
USP18 1630.5
STAT1 1477.0
OAS3 1245.0
ADAR 1048.0
IRF3 817.0
IFNAR1 574.0
EGR1 400.0
XAF1 -732.0
IFI27 -1064.0
TYK2 -1243.0
IRF8 -1433.0
IFIT2 -1925.0
RNASEL -2060.0
JAK1 -2079.0
PTPN11 -2745.0
ISG20 -3046.0
IRF5 -3455.0
OASL -4203.0
IRF4 -4529.0
IRF6 -4871.0
IFNB1 -5873.0
PTPN6 -6221.0


TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
1167
set TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
setSize 12
pANOVA 0.097
s.dist 0.277
p.adjustANOVA 0.868



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFSF14 6742
TNFRSF13C 5844
BIRC2 5444
CD40LG 4917
TNFSF13B 4453
TNFSF11 3329
TNFRSF11A 3088
CD40 1027
BIRC3 67
TRAF2 -232
LTBR -4024
TRAF3 -5705

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFSF14 6742
TNFRSF13C 5844
BIRC2 5444
CD40LG 4917
TNFSF13B 4453
TNFSF11 3329
TNFRSF11A 3088
CD40 1027
BIRC3 67
TRAF2 -232
LTBR -4024
TRAF3 -5705


Activation of SMO

Activation of SMO
47
set Activation of SMO
setSize 10
pANOVA 0.131
s.dist -0.276
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
EVC2 -6415
IHH -5051
CDON -4290
IQCE -3774
GAS1 -2657
KIF3A -1949
ARRB1 -1932
EVC 479
DHH 3489
SMO 4573

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EVC2 -6415
IHH -5051
CDON -4290
IQCE -3774
GAS1 -2657
KIF3A -1949
ARRB1 -1932
EVC 479
DHH 3489
SMO 4573


Initiation of Nuclear Envelope (NE) Reformation

Initiation of Nuclear Envelope (NE) Reformation
526
set Initiation of Nuclear Envelope (NE) Reformation
setSize 14
pANOVA 0.0745
s.dist 0.275
p.adjustANOVA 0.851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1A 6383
LMNB1 5835
CDK1 5332
VRK2 5172
CCNB1 4806
PPP2CA 4097
LMNA 3792
ANKLE2 3472
LEMD2 1470
SIRT2 83
KPNB1 -1007
LBR -1967
TMPO -2125
VRK1 -6372

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1A 6383
LMNB1 5835
CDK1 5332
VRK2 5172
CCNB1 4806
PPP2CA 4097
LMNA 3792
ANKLE2 3472
LEMD2 1470
SIRT2 83
KPNB1 -1007
LBR -1967
TMPO -2125
VRK1 -6372


Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol
1151
set Synthesis of bile acids and bile salts via 27-hydroxycholesterol
setSize 10
pANOVA 0.133
s.dist -0.275
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP8B1 -6368
CYP7A1 -4085
PTGIS -2524
RXRA -2518
NCOA2 -1466
NCOA1 -1334
CYP27A1 -779
HSD3B7 -535
NR1H4 1031
AKR1D1 1120

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP8B1 -6368
CYP7A1 -4085
PTGIS -2524
RXRA -2518
NCOA2 -1466
NCOA1 -1334
CYP27A1 -779
HSD3B7 -535
NR1H4 1031
AKR1D1 1120


Cleavage of the damaged purine

Cleavage of the damaged purine
191
set Cleavage of the damaged purine
setSize 10
pANOVA 0.135
s.dist 0.273
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEIL3 6805
TERF1 4628
MUTYH 4387
TERF2 3703
H2AFX 3215
MPG 1693
ACD 1227
POT1 -389
TINF2 -2250
OGG1 -2458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEIL3 6805
TERF1 4628
MUTYH 4387
TERF2 3703
H2AFX 3215
MPG 1693
ACD 1227
POT1 -389
TINF2 -2250
OGG1 -2458


Depurination

Depurination
269
set Depurination
setSize 10
pANOVA 0.135
s.dist 0.273
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEIL3 6805
TERF1 4628
MUTYH 4387
TERF2 3703
H2AFX 3215
MPG 1693
ACD 1227
POT1 -389
TINF2 -2250
OGG1 -2458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEIL3 6805
TERF1 4628
MUTYH 4387
TERF2 3703
H2AFX 3215
MPG 1693
ACD 1227
POT1 -389
TINF2 -2250
OGG1 -2458


Recognition and association of DNA glycosylase with site containing an affected purine

Recognition and association of DNA glycosylase with site containing an affected purine
916
set Recognition and association of DNA glycosylase with site containing an affected purine
setSize 10
pANOVA 0.135
s.dist 0.273
p.adjustANOVA 0.885



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEIL3 6805
TERF1 4628
MUTYH 4387
TERF2 3703
H2AFX 3215
MPG 1693
ACD 1227
POT1 -389
TINF2 -2250
OGG1 -2458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEIL3 6805
TERF1 4628
MUTYH 4387
TERF2 3703
H2AFX 3215
MPG 1693
ACD 1227
POT1 -389
TINF2 -2250
OGG1 -2458


Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
442
set Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
setSize 25
pANOVA 0.0185
s.dist 0.272
p.adjustANOVA 0.808



Top enriched genes

Top 20 genes
GeneID Gene Rank
PAK2 6878.0
RAP1B 6508.0
HNRNPF 6411.0
SERPINB2 6061.0
TALDO1 6058.0
LMNB1 5835.0
RALA 5608.0
PITPNA 5434.0
CNN2 5282.0
GSTA2 5192.5
IL10 4850.0
LCP1 4548.0
STAT4 3508.0
ANXA2 2930.0
IFNG 2530.0
CA1 2039.0
PDCD4 1598.0
MIF -746.0
SNRPA1 -2947.0
HSPA9 -3292.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAK2 6878.0
RAP1B 6508.0
HNRNPF 6411.0
SERPINB2 6061.0
TALDO1 6058.0
LMNB1 5835.0
RALA 5608.0
PITPNA 5434.0
CNN2 5282.0
GSTA2 5192.5
IL10 4850.0
LCP1 4548.0
STAT4 3508.0
ANXA2 2930.0
IFNG 2530.0
CA1 2039.0
PDCD4 1598.0
MIF -746.0
SNRPA1 -2947.0
HSPA9 -3292.0
GSTO1 -3541.0
MTAP -3688.5
PSME2 -4032.0
CDC42 -5214.0
PPIA -6637.0


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] fgsea_1.14.0                gplots_3.0.3               
##  [9] DESeq2_1.28.1               SummarizedExperiment_1.18.1
## [11] DelayedArray_0.14.0         matrixStats_0.56.0         
## [13] Biobase_2.48.0              GenomicRanges_1.40.0       
## [15] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [17] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [19] reshape2_1.4.4              forcats_0.5.0              
## [21] stringr_1.4.0               dplyr_1.0.0                
## [23] purrr_0.3.4                 readr_1.3.1                
## [25] tidyr_1.1.0                 tibble_3.0.1               
## [27] ggplot2_3.3.2               tidyverse_1.3.0            
## [29] locfit_1.5-9.4              statmod_1.4.34             
## [31] plyr_1.8.6                 
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] farver_2.0.3           bit64_0.9-7            AnnotationDbi_1.50.1  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.29            
## [16] jsonlite_1.7.0         broom_0.5.6            annotate_1.66.0       
## [19] dbplyr_1.4.4           shiny_1.5.0            compiler_4.0.2        
## [22] httr_1.4.1             backports_1.1.8        assertthat_0.2.1      
## [25] Matrix_1.2-18          fastmap_1.0.1          cli_2.0.2             
## [28] later_1.1.0.1          prettyunits_1.1.1      htmltools_0.5.0       
## [31] tools_4.0.2            gtable_0.3.0           glue_1.4.1            
## [34] GenomeInfoDbData_1.2.3 fastmatch_1.1-0        Rcpp_1.0.4.6          
## [37] cellranger_1.1.0       vctrs_0.3.1            gdata_2.18.0          
## [40] nlme_3.1-148           xfun_0.15              testthat_2.3.2        
## [43] rvest_0.3.5            mime_0.9               lifecycle_0.2.0       
## [46] XML_3.99-0.3           zlibbioc_1.34.0        MASS_7.3-51.6         
## [49] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [52] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [55] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [58] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [61] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [64] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [67] evaluate_0.14          lattice_0.20-41        labeling_0.3          
## [70] htmlwidgets_1.5.1      bit_1.1-15.2           tidyselect_1.1.0      
## [73] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [76] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [79] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [82] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [85] rmarkdown_2.3          progress_1.2.2         grid_4.0.2            
## [88] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [91] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [94] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report