Mitch Report

date generated: 2020-07-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## 5S_rRNA -0.3821782
## A1BG    -0.2928114
## A1CF     0.5821008
## A2M     -1.4404703
## A3GALT2  2.2664941
## A4GALT   0.8781088

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2400
num_genes_in_profile	13738
duplicated_genes_present	0
num_profile_genes_in_sets	7364
num_profile_genes_not_in_sets	6374

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1075
num_genesets_included	1325

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
TRAF6 mediated IRF7 activation	27	1.46e-06	-0.536	0.00124
eNOS activation	10	5.06e-03	-0.512	0.39400
Metabolism of nitric oxide: NOS3 activation and regulation	14	1.24e-03	-0.498	0.25300
Retrograde neurotrophin signalling	12	4.20e-03	-0.477	0.39400
TNFR1-induced proapoptotic signaling	12	7.40e-03	-0.447	0.41200
Interleukin-35 Signalling	11	1.13e-02	0.441	0.41500
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	19	9.56e-04	-0.438	0.25300
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	2.37e-02	-0.413	0.43600
SHC1 events in EGFR signaling	10	2.78e-02	-0.402	0.45400
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	13	1.28e-02	-0.399	0.41500
Regulation of TP53 Activity through Association with Co-factors	11	2.24e-02	-0.398	0.43600
Regulation of FZD by ubiquitination	13	1.45e-02	0.392	0.41500
Regulation of IFNA signaling	23	1.34e-03	-0.387	0.25300
TP53 Regulates Transcription of Death Receptors and Ligands	10	3.44e-02	-0.386	0.49900
Signal regulatory protein family interactions	11	2.74e-02	-0.384	0.45400
Classical antibody-mediated complement activation	10	3.91e-02	-0.377	0.53900
ER Quality Control Compartment (ERQC)	12	2.43e-02	-0.375	0.44200
Deposition of new CENPA-containing nucleosomes at the centromere	16	9.65e-03	-0.374	0.41200
Nucleosome assembly	16	9.65e-03	-0.374	0.41200
Regulation of TLR by endogenous ligand	13	2.25e-02	-0.366	0.43600
DDX58/IFIH1-mediated induction of interferon-alpha/beta	58	1.88e-06	-0.362	0.00124
Passive transport by Aquaporins	12	3.05e-02	0.361	0.47400
Resolution of D-Loop Structures	23	2.86e-03	-0.359	0.39400
RNA Pol II CTD phosphorylation and interaction with CE	15	1.89e-02	-0.350	0.42000
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	15	1.89e-02	-0.350	0.42000
Resolution of D-loop Structures through Holliday Junction Intermediates	22	4.96e-03	-0.346	0.39400
HIV elongation arrest and recovery	15	2.33e-02	-0.338	0.43600
Pausing and recovery of HIV elongation	15	2.33e-02	-0.338	0.43600
Pausing and recovery of Tat-mediated HIV elongation	15	2.33e-02	-0.338	0.43600
Tat-mediated HIV elongation arrest and recovery	15	2.33e-02	-0.338	0.43600
VLDLR internalisation and degradation	11	5.22e-02	-0.338	0.66300
mRNA Capping	16	2.08e-02	-0.334	0.43600
Other interleukin signaling	17	1.77e-02	0.332	0.42000
CD28 dependent PI3K/Akt signaling	19	1.64e-02	-0.318	0.41500
Glutathione synthesis and recycling	11	7.00e-02	-0.316	0.68000
VEGFR2 mediated vascular permeability	24	7.62e-03	-0.315	0.41200
Budding and maturation of HIV virion	17	2.61e-02	-0.312	0.45400
PKA activation	16	3.17e-02	0.310	0.47700
Downregulation of ERBB2 signaling	18	2.33e-02	-0.309	0.43600
NOTCH3 Activation and Transmission of Signal to the Nucleus	17	2.75e-02	-0.309	0.45400
Class I peroxisomal membrane protein import	11	7.94e-02	-0.306	0.68300
Translesion Synthesis by POLH	11	7.95e-02	0.305	0.68300
Signaling by Leptin	10	9.92e-02	0.301	0.73800
FOXO-mediated transcription of cell death genes	13	6.29e-02	0.298	0.66300
ERBB2 Activates PTK6 Signaling	10	1.05e-01	-0.296	0.75600
NOTCH2 intracellular domain regulates transcription	10	1.06e-01	-0.295	0.75800
Role of phospholipids in phagocytosis	25	1.09e-02	-0.294	0.41500
TRAF6 mediated NF-kB activation	19	2.71e-02	-0.293	0.45400
PINK1-PRKN Mediated Mitophagy	14	5.79e-02	-0.293	0.66300
Regulation of TNFR1 signaling	25	1.14e-02	-0.292	0.41500

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
TRAF6 mediated IRF7 activation	27	1.46e-06	-0.536000	0.00124
eNOS activation	10	5.06e-03	-0.512000	0.39400
Metabolism of nitric oxide: NOS3 activation and regulation	14	1.24e-03	-0.498000	0.25300
Retrograde neurotrophin signalling	12	4.20e-03	-0.477000	0.39400
TNFR1-induced proapoptotic signaling	12	7.40e-03	-0.447000	0.41200
Interleukin-35 Signalling	11	1.13e-02	0.441000	0.41500
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	19	9.56e-04	-0.438000	0.25300
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	2.37e-02	-0.413000	0.43600
SHC1 events in EGFR signaling	10	2.78e-02	-0.402000	0.45400
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	13	1.28e-02	-0.399000	0.41500
Regulation of TP53 Activity through Association with Co-factors	11	2.24e-02	-0.398000	0.43600
Regulation of FZD by ubiquitination	13	1.45e-02	0.392000	0.41500
Regulation of IFNA signaling	23	1.34e-03	-0.387000	0.25300
TP53 Regulates Transcription of Death Receptors and Ligands	10	3.44e-02	-0.386000	0.49900
Signal regulatory protein family interactions	11	2.74e-02	-0.384000	0.45400
Classical antibody-mediated complement activation	10	3.91e-02	-0.377000	0.53900
ER Quality Control Compartment (ERQC)	12	2.43e-02	-0.375000	0.44200
Deposition of new CENPA-containing nucleosomes at the centromere	16	9.65e-03	-0.374000	0.41200
Nucleosome assembly	16	9.65e-03	-0.374000	0.41200
Regulation of TLR by endogenous ligand	13	2.25e-02	-0.366000	0.43600
DDX58/IFIH1-mediated induction of interferon-alpha/beta	58	1.88e-06	-0.362000	0.00124
Passive transport by Aquaporins	12	3.05e-02	0.361000	0.47400
Resolution of D-Loop Structures	23	2.86e-03	-0.359000	0.39400
RNA Pol II CTD phosphorylation and interaction with CE	15	1.89e-02	-0.350000	0.42000
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	15	1.89e-02	-0.350000	0.42000
Resolution of D-loop Structures through Holliday Junction Intermediates	22	4.96e-03	-0.346000	0.39400
HIV elongation arrest and recovery	15	2.33e-02	-0.338000	0.43600
Pausing and recovery of HIV elongation	15	2.33e-02	-0.338000	0.43600
Pausing and recovery of Tat-mediated HIV elongation	15	2.33e-02	-0.338000	0.43600
Tat-mediated HIV elongation arrest and recovery	15	2.33e-02	-0.338000	0.43600
VLDLR internalisation and degradation	11	5.22e-02	-0.338000	0.66300
mRNA Capping	16	2.08e-02	-0.334000	0.43600
Other interleukin signaling	17	1.77e-02	0.332000	0.42000
CD28 dependent PI3K/Akt signaling	19	1.64e-02	-0.318000	0.41500
Glutathione synthesis and recycling	11	7.00e-02	-0.316000	0.68000
VEGFR2 mediated vascular permeability	24	7.62e-03	-0.315000	0.41200
Budding and maturation of HIV virion	17	2.61e-02	-0.312000	0.45400
PKA activation	16	3.17e-02	0.310000	0.47700
Downregulation of ERBB2 signaling	18	2.33e-02	-0.309000	0.43600
NOTCH3 Activation and Transmission of Signal to the Nucleus	17	2.75e-02	-0.309000	0.45400
Class I peroxisomal membrane protein import	11	7.94e-02	-0.306000	0.68300
Translesion Synthesis by POLH	11	7.95e-02	0.305000	0.68300
Signaling by Leptin	10	9.92e-02	0.301000	0.73800
FOXO-mediated transcription of cell death genes	13	6.29e-02	0.298000	0.66300
ERBB2 Activates PTK6 Signaling	10	1.05e-01	-0.296000	0.75600
NOTCH2 intracellular domain regulates transcription	10	1.06e-01	-0.295000	0.75800
Role of phospholipids in phagocytosis	25	1.09e-02	-0.294000	0.41500
TRAF6 mediated NF-kB activation	19	2.71e-02	-0.293000	0.45400
PINK1-PRKN Mediated Mitophagy	14	5.79e-02	-0.293000	0.66300
Regulation of TNFR1 signaling	25	1.14e-02	-0.292000	0.41500
ZBP1(DAI) mediated induction of type I IFNs	19	2.76e-02	-0.292000	0.45400
Regulation of TP53 Activity through Acetylation	22	1.85e-02	-0.290000	0.42000
Homologous DNA Pairing and Strand Exchange	28	8.23e-03	-0.289000	0.41200
Rap1 signalling	14	6.32e-02	0.287000	0.66300
Regulation of PTEN mRNA translation	11	1.17e-01	0.273000	0.77600
HDR through Single Strand Annealing (SSA)	26	1.59e-02	-0.273000	0.41500
EGFR downregulation	22	2.69e-02	-0.273000	0.45400
PKA activation in glucagon signalling	15	7.02e-02	0.270000	0.68000
Fatty acids	11	1.22e-01	-0.269000	0.77600
Regulation of signaling by CBL	15	7.19e-02	0.268000	0.68000
Branched-chain amino acid catabolism	19	4.40e-02	-0.267000	0.58300
PKA-mediated phosphorylation of CREB	17	5.90e-02	0.265000	0.66300
Formation of the cornified envelope	30	1.31e-02	-0.262000	0.41500
Interleukin-20 family signaling	20	4.31e-02	0.261000	0.57700
Signal transduction by L1	15	8.01e-02	0.261000	0.68300
Kinesins	34	8.91e-03	-0.259000	0.41200
FCGR activation	15	8.94e-02	-0.253000	0.72200
Presynaptic phase of homologous DNA pairing and strand exchange	25	2.84e-02	-0.253000	0.45400
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	11	1.47e-01	0.253000	0.77600
Signaling by cytosolic FGFR1 fusion mutants	16	8.04e-02	0.253000	0.68300
Organic cation/anion/zwitterion transport	13	1.15e-01	0.252000	0.77600
RIP-mediated NFkB activation via ZBP1	15	9.29e-02	-0.251000	0.72900
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	6.65e-02	-0.250000	0.66800
Telomere Extension By Telomerase	16	8.48e-02	0.249000	0.70200
Repression of WNT target genes	11	1.58e-01	0.246000	0.77600
Pre-NOTCH Transcription and Translation	31	1.90e-02	-0.243000	0.42000
Mitophagy	18	7.47e-02	-0.243000	0.68300
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	1.46e-01	-0.243000	0.77600
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	1.08e-01	0.240000	0.76400
Diseases associated with the TLR signaling cascade	18	7.87e-02	-0.239000	0.68300
Diseases of Immune System	18	7.87e-02	-0.239000	0.68300
Platelet Adhesion to exposed collagen	11	1.74e-01	0.237000	0.77600
GAB1 signalosome	14	1.26e-01	-0.236000	0.77600
Signaling by Hippo	17	9.21e-02	0.236000	0.72700
RUNX3 regulates NOTCH signaling	13	1.43e-01	-0.235000	0.77600
Adenylate cyclase activating pathway	10	1.99e-01	0.234000	0.77600
SHC1 events in ERBB2 signaling	17	9.90e-02	-0.231000	0.73800
Insulin processing	17	9.90e-02	0.231000	0.73800
p38MAPK events	11	1.85e-01	0.231000	0.77600
Synthesis of glycosylphosphatidylinositol (GPI)	10	2.09e-01	0.229000	0.79100
GRB2 events in ERBB2 signaling	11	1.89e-01	-0.229000	0.77600
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	1.72e-01	-0.228000	0.77600
Calnexin/calreticulin cycle	15	1.27e-01	-0.228000	0.77600
CASP8 activity is inhibited	10	2.16e-01	-0.226000	0.79400
Dimerization of procaspase-8	10	2.16e-01	-0.226000	0.79400
Regulation by c-FLIP	10	2.16e-01	-0.226000	0.79400
Formation of HIV elongation complex in the absence of HIV Tat	23	6.23e-02	-0.225000	0.66300
Formation of HIV-1 elongation complex containing HIV-1 Tat	23	6.23e-02	-0.225000	0.66300
HIV Transcription Elongation	23	6.23e-02	-0.225000	0.66300
Tat-mediated elongation of the HIV-1 transcript	23	6.23e-02	-0.225000	0.66300
Cleavage of the damaged purine	10	2.24e-01	0.222000	0.79900
Depurination	10	2.24e-01	0.222000	0.79900
Recognition and association of DNA glycosylase with site containing an affected purine	10	2.24e-01	0.222000	0.79900
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	12	1.84e-01	0.222000	0.77600
Zinc transporters	12	1.85e-01	-0.221000	0.77600
Abacavir transport and metabolism	10	2.27e-01	0.221000	0.79900
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	1.85e-01	0.221000	0.77600
Mitochondrial protein import	44	1.14e-02	-0.221000	0.41500
p75NTR signals via NF-kB	10	2.29e-01	-0.220000	0.79900
InlB-mediated entry of Listeria monocytogenes into host cell	10	2.30e-01	-0.219000	0.79900
Regulation of innate immune responses to cytosolic DNA	11	2.16e-01	-0.216000	0.79400
Synthesis of PC	20	9.60e-02	0.215000	0.73300
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	2.42e-01	-0.214000	0.80800
Pre-NOTCH Expression and Processing	44	1.46e-02	-0.213000	0.41500
TNFR1-induced NFkappaB signaling pathway	22	8.42e-02	-0.213000	0.70200
Miscellaneous transport and binding events	17	1.29e-01	-0.213000	0.77600
Lysine catabolism	10	2.45e-01	0.212000	0.81000
WNT5A-dependent internalization of FZD4	11	2.24e-01	-0.212000	0.79900
HDR through Homologous Recombination (HRR)	43	1.71e-02	-0.210000	0.41900
Interferon gamma signaling	55	7.09e-03	-0.210000	0.41200
Abortive elongation of HIV-1 transcript in the absence of Tat	12	2.10e-01	-0.209000	0.79100
DNA Double Strand Break Response	34	3.50e-02	-0.209000	0.49900
Other semaphorin interactions	18	1.25e-01	0.209000	0.77600
N-Glycan antennae elongation	12	2.12e-01	0.208000	0.79400
Transcription of E2F targets under negative control by DREAM complex	16	1.53e-01	0.206000	0.77600
TP53 Regulates Transcription of DNA Repair Genes	38	2.83e-02	-0.206000	0.45400
Physiological factors	10	2.62e-01	-0.205000	0.82500
Selective autophagy	47	1.56e-02	-0.204000	0.41500
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	19	1.26e-01	-0.203000	0.77600
Synthesis of IP2, IP, and Ins in the cytosol	13	2.09e-01	0.201000	0.79100
Assembly of active LPL and LIPC lipase complexes	16	1.65e-01	-0.201000	0.77600
ERBB2 Regulates Cell Motility	11	2.50e-01	-0.201000	0.81300
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	11	2.50e-01	0.200000	0.81300
Inactivation of APC/C via direct inhibition of the APC/C complex	18	1.43e-01	-0.199000	0.77600
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	18	1.43e-01	-0.199000	0.77600
Aspartate and asparagine metabolism	10	2.81e-01	-0.197000	0.84500
TRAF3-dependent IRF activation pathway	13	2.20e-01	-0.196000	0.79900
TNF signaling	32	5.50e-02	-0.196000	0.66300
Extra-nuclear estrogen signaling	60	8.91e-03	-0.195000	0.41200
RNA polymerase II transcribes snRNA genes	47	2.07e-02	-0.195000	0.43600
Glutamate Neurotransmitter Release Cycle	19	1.41e-01	0.195000	0.77600
Late endosomal microautophagy	21	1.22e-01	-0.195000	0.77600
TP53 Regulates Transcription of Cell Death Genes	30	6.53e-02	-0.195000	0.66500
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	31	6.13e-02	0.194000	0.66300
Aquaporin-mediated transport	42	3.07e-02	0.193000	0.47400
Interferon alpha/beta signaling	50	1.85e-02	-0.193000	0.42000
Class C/3 (Metabotropic glutamate/pheromone receptors)	17	1.70e-01	0.192000	0.77600
Signaling by BMP	25	9.67e-02	-0.192000	0.73300
Signaling by FGFR1 in disease	31	6.46e-02	0.192000	0.66300
Positive epigenetic regulation of rRNA expression	32	6.07e-02	-0.192000	0.66300
Negative epigenetic regulation of rRNA expression	29	7.42e-02	-0.192000	0.68300
Negative regulators of DDX58/IFIH1 signaling	21	1.29e-01	-0.192000	0.77600
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	8.55e-02	0.191000	0.70200
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	17	1.74e-01	0.191000	0.77600
Neurodegenerative Diseases	17	1.74e-01	0.191000	0.77600
APC-Cdc20 mediated degradation of Nek2A	20	1.41e-01	-0.190000	0.77600
Gap junction assembly	15	2.02e-01	-0.190000	0.78300
RNA Polymerase I Transcription	34	5.54e-02	-0.190000	0.66300
RNA Polymerase I Transcription Termination	17	1.76e-01	-0.190000	0.77600
Downstream signal transduction	25	1.02e-01	0.189000	0.74300
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	11	2.78e-01	0.189000	0.84500
Transcription of the HIV genome	44	3.13e-02	-0.188000	0.47700
RNA Polymerase I Transcription Initiation	30	7.58e-02	-0.187000	0.68300
Regulation of Complement cascade	37	4.87e-02	-0.187000	0.62700
Purine ribonucleoside monophosphate biosynthesis	11	2.83e-01	-0.187000	0.84900
Interleukin-6 family signaling	20	1.48e-01	0.187000	0.77600
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	33	6.37e-02	-0.187000	0.66300
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	3.07e-01	-0.187000	0.87100
Interleukin-12 family signaling	41	3.90e-02	0.186000	0.53900
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	2.88e-01	0.185000	0.84900
E2F mediated regulation of DNA replication	18	1.74e-01	-0.185000	0.77600
Nucleotide-like (purinergic) receptors	11	2.91e-01	0.184000	0.84900
Mitochondrial calcium ion transport	17	1.89e-01	0.184000	0.77600
Meiotic recombination	19	1.66e-01	-0.183000	0.77600
Interleukin-12 signaling	32	7.27e-02	0.183000	0.68300
Cell recruitment (pro-inflammatory response)	18	1.80e-01	-0.183000	0.77600
Purinergic signaling in leishmaniasis infection	18	1.80e-01	-0.183000	0.77600
Activated NOTCH1 Transmits Signal to the Nucleus	20	1.59e-01	-0.182000	0.77600
Formation of the beta-catenin:TCF transactivating complex	29	9.03e-02	0.182000	0.72500
Late Phase of HIV Life Cycle	86	3.64e-03	-0.182000	0.39400
Depolymerisation of the Nuclear Lamina	13	2.58e-01	0.181000	0.82100
DAG and IP3 signaling	35	6.41e-02	0.181000	0.66300
Signaling by EGFR	37	5.77e-02	-0.180000	0.66300
Adherens junctions interactions	17	1.99e-01	-0.180000	0.77600
COPI-dependent Golgi-to-ER retrograde traffic	62	1.45e-02	-0.180000	0.41500
NOTCH4 Intracellular Domain Regulates Transcription	18	1.87e-01	-0.180000	0.77600
Nonhomologous End-Joining (NHEJ)	24	1.29e-01	-0.179000	0.77600
CD28 co-stimulation	28	1.02e-01	-0.179000	0.74300
Glucagon signaling in metabolic regulation	25	1.23e-01	0.178000	0.77600
Regulation of gene expression by Hypoxia-inducible Factor	11	3.06e-01	0.178000	0.87100
Activation of the TFAP2 (AP-2) family of transcription factors	10	3.30e-01	0.178000	0.89200
Aberrant regulation of mitotic cell cycle due to RB1 defects	30	9.15e-02	-0.178000	0.72600
Diseases of mitotic cell cycle	30	9.15e-02	-0.178000	0.72600
Signaling by Activin	12	2.88e-01	0.177000	0.84900
RNA Polymerase I Promoter Clearance	33	8.03e-02	-0.176000	0.68300
Gap junction trafficking	23	1.45e-01	-0.176000	0.77600
PERK regulates gene expression	20	1.75e-01	0.175000	0.77600
Signaling by NOTCH3	38	6.19e-02	-0.175000	0.66300
Nucleobase biosynthesis	13	2.75e-01	-0.175000	0.84100
Aflatoxin activation and detoxification	15	2.42e-01	-0.174000	0.80800
Tie2 Signaling	15	2.43e-01	0.174000	0.80800
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	25	1.32e-01	0.174000	0.77600
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	54	2.78e-02	-0.173000	0.45400
Signalling to ERKs	29	1.07e-01	0.173000	0.76400
HIV Life Cycle	94	3.96e-03	-0.172000	0.39400
Diseases of programmed cell death	18	2.08e-01	0.172000	0.79100
ROS and RNS production in phagocytes	26	1.31e-01	-0.171000	0.77600
PECAM1 interactions	10	3.48e-01	0.171000	0.90100
Na+/Cl- dependent neurotransmitter transporters	15	2.52e-01	0.171000	0.81300
Signaling by NOTCH2	22	1.67e-01	-0.170000	0.77600
Formation of Incision Complex in GG-NER	28	1.19e-01	0.170000	0.77600
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	11	3.30e-01	0.170000	0.89200
Regulation of gene expression in beta cells	13	2.90e-01	-0.169000	0.84900
FOXO-mediated transcription of cell cycle genes	14	2.73e-01	0.169000	0.84000
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	3.32e-01	0.169000	0.89200
FGFR1 mutant receptor activation	26	1.38e-01	0.168000	0.77600
Metabolism of Angiotensinogen to Angiotensins	13	2.94e-01	-0.168000	0.85600
MECP2 regulates neuronal receptors and channels	14	2.79e-01	0.167000	0.84500
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	17	2.33e-01	0.167000	0.80300
Signaling by ERBB2	35	8.75e-02	-0.167000	0.71200
Processive synthesis on the C-strand of the telomere	13	2.98e-01	0.167000	0.86300
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	11	3.39e-01	0.166000	0.89500
Phosphorylation of the APC/C	17	2.35e-01	-0.166000	0.80600
Metabolism of cofactors	18	2.24e-01	-0.166000	0.79900
NIK-->noncanonical NF-kB signaling	38	7.81e-02	-0.165000	0.68300
MHC class II antigen presentation	84	8.96e-03	-0.165000	0.41200
Signalling to RAS	16	2.53e-01	0.165000	0.81300
DNA Damage Recognition in GG-NER	25	1.54e-01	0.165000	0.77600
G2/M DNA damage checkpoint	43	6.20e-02	-0.165000	0.66300
Inositol phosphate metabolism	39	7.55e-02	0.165000	0.68300
Elevation of cytosolic Ca2+ levels	11	3.45e-01	-0.164000	0.90000
Dectin-1 mediated noncanonical NF-kB signaling	41	6.86e-02	-0.164000	0.67900
Autodegradation of Cdh1 by Cdh1:APC/C	45	5.71e-02	-0.164000	0.66300
Glycogen breakdown (glycogenolysis)	11	3.51e-01	0.162000	0.90100
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	11	3.53e-01	0.162000	0.90300
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	14	2.96e-01	0.161000	0.85900
Leading Strand Synthesis	12	3.36e-01	-0.161000	0.89200
Polymerase switching	12	3.36e-01	-0.161000	0.89200
NoRC negatively regulates rRNA expression	26	1.59e-01	-0.160000	0.77600
HS-GAG biosynthesis	22	1.95e-01	-0.160000	0.77600
Caspase activation via Death Receptors in the presence of ligand	14	3.01e-01	-0.160000	0.86300
APC/C:Cdc20 mediated degradation of Securin	49	5.44e-02	-0.159000	0.66300
Interleukin-27 signaling	10	3.85e-01	0.159000	0.90700
Activation of Matrix Metalloproteinases	23	1.89e-01	-0.158000	0.77600
Regulation of PTEN stability and activity	45	6.66e-02	-0.158000	0.66800
Reduction of cytosolic Ca++ levels	11	3.64e-01	0.158000	0.90700
G2/M Checkpoints	90	9.64e-03	-0.158000	0.41200
Signaling by EGFR in Cancer	17	2.61e-01	-0.157000	0.82400
N-glycan antennae elongation in the medial/trans-Golgi	19	2.37e-01	0.157000	0.80600
Endosomal Sorting Complex Required For Transport (ESCRT)	19	2.39e-01	-0.156000	0.80600
Stabilization of p53	38	9.68e-02	-0.156000	0.73300
Receptor-type tyrosine-protein phosphatases	14	3.14e-01	-0.156000	0.88100
Growth hormone receptor signaling	19	2.42e-01	0.155000	0.80800
Acyl chain remodelling of PG	15	3.00e-01	0.155000	0.86300
Regulation of necroptotic cell death	12	3.54e-01	-0.155000	0.90300
AUF1 (hnRNP D0) binds and destabilizes mRNA	36	1.09e-01	-0.154000	0.76400
The role of Nef in HIV-1 replication and disease pathogenesis	22	2.11e-01	0.154000	0.79400
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	10	4.01e-01	-0.153000	0.90700
Serotonin Neurotransmitter Release Cycle	11	3.80e-01	0.153000	0.90700
Interferon Signaling	131	2.65e-03	-0.152000	0.39400
ATF4 activates genes in response to endoplasmic reticulum stress	18	2.64e-01	0.152000	0.82600
Factors involved in megakaryocyte development and platelet production	99	9.23e-03	-0.152000	0.41200
CDT1 association with the CDC6:ORC:origin complex	39	1.02e-01	-0.151000	0.74300
Regulation of TP53 Activity	120	4.29e-03	-0.151000	0.39400
Chaperone Mediated Autophagy	15	3.11e-01	-0.151000	0.87700
Golgi Cisternae Pericentriolar Stack Reorganization	11	3.86e-01	0.151000	0.90700
mRNA Splicing - Minor Pathway	30	1.53e-01	-0.151000	0.77600
Formation of RNA Pol II elongation complex	33	1.34e-01	-0.151000	0.77600
RNA Polymerase II Transcription Elongation	33	1.34e-01	-0.151000	0.77600
Signaling by ERBB4	41	9.57e-02	-0.150000	0.73300
Signaling by WNT in cancer	27	1.77e-01	0.150000	0.77600
NS1 Mediated Effects on Host Pathways	26	1.87e-01	-0.149000	0.77600
CaM pathway	29	1.64e-01	0.149000	0.77600
Calmodulin induced events	29	1.64e-01	0.149000	0.77600
Glycogen metabolism	20	2.50e-01	0.149000	0.81300
Ca-dependent events	31	1.52e-01	0.149000	0.77600
Recycling pathway of L1	25	1.99e-01	-0.148000	0.77600
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	68	3.47e-02	-0.148000	0.49900
Cell-extracellular matrix interactions	14	3.37e-01	-0.148000	0.89400
Homology Directed Repair	72	3.00e-02	-0.148000	0.47300
RET signaling	34	1.37e-01	0.148000	0.77600
BMAL1:CLOCK,NPAS2 activates circadian gene expression	20	2.59e-01	0.146000	0.82300
Glycosphingolipid metabolism	31	1.62e-01	-0.145000	0.77600
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	22	2.39e-01	0.145000	0.80600
Degradation of AXIN	36	1.32e-01	-0.145000	0.77600
DNA Double-Strand Break Repair	93	1.60e-02	-0.145000	0.41500
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	2.89e-01	-0.145000	0.84900
RAF-independent MAPK1/3 activation	18	2.89e-01	0.144000	0.84900
Heme biosynthesis	11	4.09e-01	0.144000	0.90700
activated TAK1 mediates p38 MAPK activation	15	3.36e-01	0.144000	0.89200
Switching of origins to a post-replicative state	64	4.73e-02	-0.144000	0.62000
CDK-mediated phosphorylation and removal of Cdc6	52	7.61e-02	-0.142000	0.68300
Cell Cycle Checkpoints	184	9.48e-04	-0.142000	0.25300
Synthesis of IP3 and IP4 in the cytosol	22	2.52e-01	0.141000	0.81300
Translesion synthesis by REV1	11	4.20e-01	0.141000	0.90700
Tandem pore domain potassium channels	10	4.42e-01	-0.141000	0.90700
PI-3K cascade:FGFR4	17	3.16e-01	0.140000	0.88400
Downregulation of SMAD2/3:SMAD4 transcriptional activity	15	3.46e-01	0.140000	0.90000
FGFRL1 modulation of FGFR1 signaling	12	4.01e-01	-0.140000	0.90700
Amine ligand-binding receptors	33	1.64e-01	0.140000	0.77600
Vasopressin regulates renal water homeostasis via Aquaporins	34	1.58e-01	0.140000	0.77600
ADP signalling through P2Y purinoceptor 1	19	2.91e-01	0.140000	0.84900
Acetylcholine binding and downstream events	12	4.01e-01	-0.140000	0.90700
Postsynaptic nicotinic acetylcholine receptors	12	4.01e-01	-0.140000	0.90700
Regulation of TP53 Expression and Degradation	30	1.85e-01	-0.140000	0.77600
Pre-NOTCH Processing in Golgi	14	3.65e-01	-0.140000	0.90700
Eicosanoid ligand-binding receptors	10	4.44e-01	-0.140000	0.90700
Cell surface interactions at the vascular wall	113	1.05e-02	-0.140000	0.41500
Circadian Clock	56	7.10e-02	0.140000	0.68000
Sulfur amino acid metabolism	21	2.68e-01	-0.140000	0.83200
RHO GTPases activate IQGAPs	10	4.45e-01	0.139000	0.90700
Vif-mediated degradation of APOBEC3G	33	1.66e-01	-0.139000	0.77600
Viral Messenger RNA Synthesis	25	2.28e-01	-0.139000	0.79900
Lysosome Vesicle Biogenesis	26	2.21e-01	-0.139000	0.79900
Listeria monocytogenes entry into host cells	14	3.69e-01	-0.139000	0.90700
Negative regulation of MET activity	14	3.73e-01	-0.137000	0.90700
Costimulation by the CD28 family	49	9.64e-02	-0.137000	0.73300
Translesion synthesis by POLI	12	4.11e-01	0.137000	0.90700
Gastrin-CREB signalling pathway via PKC and MAPK	15	3.58e-01	-0.137000	0.90700
G0 and Early G1	22	2.67e-01	0.137000	0.83200
Retrograde transport at the Trans-Golgi-Network	36	1.56e-01	-0.137000	0.77600
Norepinephrine Neurotransmitter Release Cycle	12	4.13e-01	0.137000	0.90700
Negative regulation of NOTCH4 signaling	36	1.60e-01	-0.135000	0.77600
Prolonged ERK activation events	12	4.19e-01	0.135000	0.90700
Nuclear signaling by ERBB4	25	2.44e-01	-0.135000	0.80900
HIV Transcription Initiation	31	1.96e-01	-0.134000	0.77600
RNA Polymerase II HIV Promoter Escape	31	1.96e-01	-0.134000	0.77600
RNA Polymerase II Promoter Escape	31	1.96e-01	-0.134000	0.77600
RNA Polymerase II Transcription Initiation	31	1.96e-01	-0.134000	0.77600
RNA Polymerase II Transcription Initiation And Promoter Clearance	31	1.96e-01	-0.134000	0.77600
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	31	1.96e-01	-0.134000	0.77600
Cross-presentation of soluble exogenous antigens (endosomes)	35	1.71e-01	-0.134000	0.77600
Prolactin receptor signaling	11	4.44e-01	0.133000	0.90700
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	3.73e-01	-0.133000	0.90700
RUNX1 regulates transcription of genes involved in differentiation of HSCs	50	1.05e-01	-0.133000	0.75600
PLC beta mediated events	46	1.20e-01	0.132000	0.77600
PI3K events in ERBB2 signaling	13	4.09e-01	-0.132000	0.90700
Signaling by ERBB2 TMD/JMD mutants	16	3.61e-01	-0.132000	0.90700
Processing of DNA double-strand break ends	43	1.34e-01	-0.132000	0.77600
Formation of the Early Elongation Complex	19	3.19e-01	-0.132000	0.88600
Formation of the HIV-1 Early Elongation Complex	19	3.19e-01	-0.132000	0.88600
Basigin interactions	23	2.74e-01	-0.132000	0.84000
Role of LAT2/NTAL/LAB on calcium mobilization	13	4.11e-01	0.132000	0.90700
TRAF6-mediated induction of TAK1 complex within TLR4 complex	11	4.49e-01	0.132000	0.90700
Deactivation of the beta-catenin transactivating complex	28	2.29e-01	0.131000	0.79900
Regulation of beta-cell development	28	2.30e-01	-0.131000	0.79900
Gap junction trafficking and regulation	25	2.57e-01	-0.131000	0.82100
Iron uptake and transport	41	1.49e-01	0.130000	0.77600
Methylation	10	4.77e-01	-0.130000	0.90700
Phospholipase C-mediated cascade; FGFR4	12	4.36e-01	0.130000	0.90700
Signaling by PDGF	46	1.28e-01	0.130000	0.77600
Mitotic Spindle Checkpoint	83	4.15e-02	-0.130000	0.56500
LGI-ADAM interactions	13	4.19e-01	0.130000	0.90700
Assembly of the pre-replicative complex	46	1.29e-01	-0.129000	0.77600
Signaling by ERBB2 in Cancer	20	3.17e-01	-0.129000	0.88500
Beta-catenin phosphorylation cascade	15	3.87e-01	0.129000	0.90700
Heparan sulfate/heparin (HS-GAG) metabolism	40	1.59e-01	-0.129000	0.77600
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	18	3.45e-01	0.129000	0.90000
APC/C:Cdc20 mediated degradation of Cyclin B	19	3.32e-01	-0.128000	0.89200
Chemokine receptors bind chemokines	38	1.71e-01	-0.128000	0.77600
GP1b-IX-V activation signalling	10	4.83e-01	0.128000	0.90700
Autodegradation of the E3 ubiquitin ligase COP1	35	1.90e-01	-0.128000	0.77600
Separation of Sister Chromatids	124	1.41e-02	-0.128000	0.41500
FGFR2 alternative splicing	14	4.08e-01	-0.128000	0.90700
G-protein mediated events	47	1.31e-01	0.127000	0.77600
Ca2+ pathway	52	1.13e-01	0.127000	0.77600
Arachidonic acid metabolism	43	1.50e-01	0.127000	0.77600
G alpha (z) signalling events	36	1.88e-01	0.127000	0.77600
KSRP (KHSRP) binds and destabilizes mRNA	13	4.30e-01	0.126000	0.90700
CYP2E1 reactions	10	4.89e-01	-0.126000	0.90700
Extension of Telomeres	36	1.91e-01	0.126000	0.77600
HIV Infection	151	7.63e-03	-0.126000	0.41200
Triglyceride biosynthesis	10	4.92e-01	-0.126000	0.90700
Regulation of RAS by GAPs	47	1.37e-01	-0.125000	0.77600
Golgi-to-ER retrograde transport	89	4.18e-02	-0.125000	0.56500
ESR-mediated signaling	128	1.51e-02	-0.125000	0.41500
mTORC1-mediated signalling	17	3.74e-01	0.125000	0.90700
Presynaptic nicotinic acetylcholine receptors	11	4.78e-01	-0.124000	0.90700
Metabolism of folate and pterines	13	4.41e-01	0.123000	0.90700
Defective CFTR causes cystic fibrosis	39	1.83e-01	-0.123000	0.77600
DNA Damage/Telomere Stress Induced Senescence	21	3.28e-01	-0.123000	0.89200
Intra-Golgi and retrograde Golgi-to-ER traffic	141	1.17e-02	-0.123000	0.41500
Epigenetic regulation of gene expression	61	9.66e-02	-0.123000	0.73300
Caspase activation via extrinsic apoptotic signalling pathway	21	3.29e-01	-0.123000	0.89200
RNA Polymerase II Pre-transcription Events	52	1.25e-01	-0.123000	0.77600
Downstream signaling events of B Cell Receptor (BCR)	55	1.15e-01	-0.123000	0.77600
CLEC7A (Dectin-1) signaling	70	7.60e-02	-0.123000	0.68300
Regulation of TP53 Degradation	29	2.53e-01	-0.123000	0.81300
Transport of the SLBP Dependant Mature mRNA	24	2.99e-01	-0.122000	0.86300
Antigen processing-Cross presentation	66	8.58e-02	-0.122000	0.70200
Signaling by NOTCH4	60	1.02e-01	-0.122000	0.74300
Purine salvage	11	4.83e-01	-0.122000	0.90700
Activation of G protein gated Potassium channels	21	3.33e-01	0.122000	0.89200
G protein gated Potassium channels	21	3.33e-01	0.122000	0.89200
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	21	3.33e-01	0.122000	0.89200
RNA Polymerase II Transcription Termination	45	1.57e-01	-0.122000	0.77600
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	13	4.47e-01	-0.122000	0.90700
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	13	4.47e-01	-0.122000	0.90700
Senescence-Associated Secretory Phenotype (SASP)	39	1.88e-01	-0.122000	0.77600
Mitotic Anaphase	171	6.08e-03	-0.122000	0.41200
Notch-HLH transcription pathway	22	3.23e-01	-0.122000	0.89200
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	35	2.13e-01	-0.122000	0.79400
trans-Golgi Network Vesicle Budding	50	1.37e-01	-0.122000	0.77600
Glucuronidation	16	4.00e-01	0.121000	0.90700
Ribosomal scanning and start codon recognition	21	3.36e-01	0.121000	0.89200
Translation initiation complex formation	21	3.36e-01	0.121000	0.89200
Interleukin-3, Interleukin-5 and GM-CSF signaling	33	2.30e-01	0.121000	0.79900
p53-Dependent G1 DNA Damage Response	45	1.62e-01	-0.121000	0.77600
p53-Dependent G1/S DNA damage checkpoint	45	1.62e-01	-0.121000	0.77600
Diseases associated with N-glycosylation of proteins	14	4.36e-01	0.120000	0.90700
PCNA-Dependent Long Patch Base Excision Repair	15	4.21e-01	0.120000	0.90700
Cleavage of the damaged pyrimidine	14	4.37e-01	-0.120000	0.90700
Depyrimidination	14	4.37e-01	-0.120000	0.90700
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	4.37e-01	-0.120000	0.90700
Processing of SMDT1	11	4.92e-01	0.120000	0.90700
Activation of NF-kappaB in B cells	44	1.71e-01	-0.119000	0.77600
Reversible hydration of carbon dioxide	10	5.13e-01	-0.119000	0.90700
Common Pathway of Fibrin Clot Formation	18	3.81e-01	0.119000	0.90700
Organic cation transport	10	5.14e-01	0.119000	0.90700
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	4.94e-01	-0.119000	0.90700
Nuclear Receptor transcription pathway	48	1.54e-01	0.119000	0.77600
NCAM1 interactions	29	2.68e-01	0.119000	0.83200
Peptide chain elongation	33	2.38e-01	0.119000	0.80600
DCC mediated attractive signaling	12	4.78e-01	0.118000	0.90700
RA biosynthesis pathway	18	3.87e-01	0.118000	0.90700
Mitotic Metaphase and Anaphase	172	7.80e-03	-0.118000	0.41200
Inhibition of DNA recombination at telomere	12	4.80e-01	-0.118000	0.90700
FRS-mediated FGFR4 signaling	16	4.16e-01	0.117000	0.90700
Hedgehog ligand biogenesis	44	1.80e-01	-0.117000	0.77600
Protein localization	113	3.20e-02	-0.117000	0.47700
Translesion synthesis by POLK	12	4.84e-01	0.117000	0.90700
PI-3K cascade:FGFR1	19	3.79e-01	0.117000	0.90700
NOTCH1 Intracellular Domain Regulates Transcription	38	2.16e-01	0.116000	0.79400
Pyruvate metabolism and Citric Acid (TCA) cycle	37	2.25e-01	-0.115000	0.79900
Effects of PIP2 hydrolysis	20	3.72e-01	-0.115000	0.90700
MicroRNA (miRNA) biogenesis	13	4.72e-01	-0.115000	0.90700
Transport of Ribonucleoproteins into the Host Nucleus	22	3.50e-01	-0.115000	0.90100
G1/S-Specific Transcription	24	3.29e-01	0.115000	0.89200
Dissolution of Fibrin Clot	12	4.90e-01	-0.115000	0.90700
WNT ligand biogenesis and trafficking	19	3.86e-01	0.115000	0.90700
Regulation of actin dynamics for phagocytic cup formation	56	1.38e-01	-0.115000	0.77600
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	54	1.46e-01	-0.115000	0.77600
Constitutive Signaling by EGFRvIII	12	4.94e-01	-0.114000	0.90700
Signaling by EGFRvIII in Cancer	12	4.94e-01	-0.114000	0.90700
Regulation of RUNX3 expression and activity	37	2.30e-01	-0.114000	0.79900
Activation of gene expression by SREBF (SREBP)	35	2.45e-01	-0.114000	0.81000
SHC-mediated cascade:FGFR3	13	4.78e-01	-0.114000	0.90700
Signaling by NOTCH	137	2.23e-02	-0.113000	0.43600
Endogenous sterols	23	3.48e-01	0.113000	0.90100
PI-3K cascade:FGFR2	20	3.82e-01	0.113000	0.90700
Synthesis of DNA	86	7.16e-02	-0.113000	0.68000
Nicotinamide salvaging	11	5.18e-01	-0.112000	0.90700
Activation of the pre-replicative complex	23	3.51e-01	-0.112000	0.90100
TNFR2 non-canonical NF-kB pathway	68	1.10e-01	-0.112000	0.76400
APC/C:Cdc20 mediated degradation of mitotic proteins	56	1.47e-01	-0.112000	0.77600
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	56	1.47e-01	-0.112000	0.77600
Hh mutants abrogate ligand secretion	38	2.33e-01	-0.112000	0.80300
mRNA Splicing - Major Pathway	117	3.70e-02	-0.112000	0.52200
Phosphorylation of CD3 and TCR zeta chains	13	4.86e-01	-0.112000	0.90700
Citric acid cycle (TCA cycle)	13	4.86e-01	-0.112000	0.90700
RHO GTPases activate PAKs	18	4.14e-01	0.111000	0.90700
Formation of the ternary complex, and subsequently, the 43S complex	18	4.14e-01	0.111000	0.90700
G1/S DNA Damage Checkpoints	46	1.92e-01	-0.111000	0.77600
Laminin interactions	22	3.68e-01	0.111000	0.90700
DAP12 interactions	25	3.38e-01	-0.111000	0.89500
RHO GTPases activate CIT	16	4.43e-01	0.111000	0.90700
Eukaryotic Translation Elongation	36	2.52e-01	0.110000	0.81300
Macroautophagy	85	8.18e-02	-0.109000	0.69100
mRNA decay by 5' to 3' exoribonuclease	12	5.13e-01	0.109000	0.90700
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	53	1.71e-01	-0.109000	0.77600
Golgi Associated Vesicle Biogenesis	38	2.47e-01	-0.109000	0.81300
Activation of the phototransduction cascade	11	5.33e-01	0.109000	0.90700
Signaling by Non-Receptor Tyrosine Kinases	40	2.36e-01	0.108000	0.80600
Signaling by PTK6	40	2.36e-01	0.108000	0.80600
Global Genome Nucleotide Excision Repair (GG-NER)	60	1.48e-01	0.108000	0.77600
NCAM signaling for neurite out-growth	46	2.05e-01	0.108000	0.78800
Creatine metabolism	10	5.56e-01	0.108000	0.90700
Signaling by KIT in disease	16	4.56e-01	0.108000	0.90700
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	4.56e-01	0.108000	0.90700
ER-Phagosome pathway	53	1.76e-01	-0.107000	0.77600
Transcriptional Regulation by TP53	256	3.20e-03	-0.107000	0.39400
Deadenylation of mRNA	16	4.59e-01	0.107000	0.90700
Activation of GABAB receptors	34	2.81e-01	0.107000	0.84500
GABA B receptor activation	34	2.81e-01	0.107000	0.84500
Nucleotide salvage	17	4.46e-01	-0.107000	0.90700
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	33	2.88e-01	-0.107000	0.84900
p53-Independent DNA Damage Response	33	2.88e-01	-0.107000	0.84900
p53-Independent G1/S DNA damage checkpoint	33	2.88e-01	-0.107000	0.84900
Complement cascade	47	2.07e-01	-0.107000	0.79000
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	68	1.29e-01	-0.106000	0.77600
Amplification of signal from the kinetochores	68	1.29e-01	-0.106000	0.77600
tRNA Aminoacylation	17	4.48e-01	-0.106000	0.90700
G-protein beta:gamma signalling	22	3.91e-01	-0.106000	0.90700
Peroxisomal lipid metabolism	23	3.81e-01	-0.106000	0.90700
Intra-Golgi traffic	34	2.88e-01	-0.105000	0.84900
IL-6-type cytokine receptor ligand interactions	15	4.82e-01	0.105000	0.90700
Creation of C4 and C2 activators	17	4.55e-01	-0.105000	0.90700
Glycogen synthesis	11	5.49e-01	0.104000	0.90700
Synthesis of bile acids and bile salts	25	3.67e-01	0.104000	0.90700
Cellular Senescence	103	6.83e-02	-0.104000	0.67900
Acyl chain remodelling of PS	16	4.71e-01	0.104000	0.90700
Synthesis of PE	10	5.69e-01	0.104000	0.91200
Signaling by Erythropoietin	20	4.23e-01	0.104000	0.90700
Autophagy	95	8.33e-02	-0.103000	0.69900
SUMOylation of DNA methylation proteins	15	4.90e-01	0.103000	0.90700
CD209 (DC-SIGN) signaling	17	4.64e-01	0.103000	0.90700
Transcriptional regulation of pluripotent stem cells	22	4.07e-01	0.102000	0.90700
TGF-beta receptor signaling activates SMADs	19	4.42e-01	-0.102000	0.90700
Removal of the Flap Intermediate from the C-strand	12	5.42e-01	0.102000	0.90700
LDL clearance	16	4.82e-01	-0.102000	0.90700
Regulation of insulin secretion	65	1.58e-01	0.101000	0.77600
Inwardly rectifying K+ channels	27	3.63e-01	0.101000	0.90700
Signaling by ERBB2 KD Mutants	19	4.45e-01	-0.101000	0.90700
Transport of Mature Transcript to Cytoplasm	59	1.80e-01	-0.101000	0.77600
Cargo recognition for clathrin-mediated endocytosis	75	1.32e-01	-0.101000	0.77600
G-protein activation	20	4.36e-01	0.101000	0.90700
Formation of tubulin folding intermediates by CCT/TriC	19	4.48e-01	-0.101000	0.90700
DNA Replication Pre-Initiation	58	1.86e-01	-0.101000	0.77600
Transport of Mature mRNA derived from an Intron-Containing Transcript	53	2.07e-01	-0.100000	0.79000
FGFR2 mutant receptor activation	20	4.39e-01	-0.099900	0.90700
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	3.88e-01	0.099800	0.90700
FGFR2c ligand binding and activation	10	5.85e-01	0.099800	0.91400
The canonical retinoid cycle in rods (twilight vision)	19	4.53e-01	0.099500	0.90700
Transport of Mature mRNAs Derived from Intronless Transcripts	29	3.54e-01	-0.099400	0.90300
S Phase	117	6.38e-02	-0.099400	0.66300
Potential therapeutics for SARS	26	3.81e-01	-0.099300	0.90700
Blood group systems biosynthesis	13	5.36e-01	0.099100	0.90700
Thromboxane signalling through TP receptor	16	4.93e-01	0.099000	0.90700
Phospholipase C-mediated cascade: FGFR1	14	5.22e-01	0.098900	0.90700
Defects in vitamin and cofactor metabolism	14	5.22e-01	-0.098800	0.90700
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	35	3.12e-01	0.098700	0.87900
PRC2 methylates histones and DNA	11	5.71e-01	-0.098700	0.91200
TCF dependent signaling in response to WNT	127	5.55e-02	0.098600	0.66300
Interactions of Rev with host cellular proteins	25	3.95e-01	-0.098400	0.90700
Opioid Signalling	74	1.45e-01	0.098200	0.77600
Transferrin endocytosis and recycling	20	4.49e-01	0.097800	0.90700
Defensins	20	4.49e-01	0.097800	0.90700
FCERI mediated MAPK activation	24	4.08e-01	0.097700	0.90700
Phase 0 - rapid depolarisation	37	3.05e-01	0.097600	0.86800
Transport of the SLBP independent Mature mRNA	23	4.19e-01	-0.097400	0.90700
Estrogen-dependent gene expression	72	1.55e-01	-0.097100	0.77600
RNA Polymerase I Promoter Escape	17	4.88e-01	-0.097100	0.90700
Triglyceride catabolism	18	4.78e-01	0.096700	0.90700
Xenobiotics	22	4.33e-01	-0.096700	0.90700
ERKs are inactivated	12	5.65e-01	0.095900	0.91100
Plasma lipoprotein assembly	12	5.66e-01	-0.095600	0.91100
Syndecan interactions	16	5.09e-01	0.095400	0.90700
Phospholipase C-mediated cascade; FGFR2	15	5.23e-01	0.095200	0.90700
Orc1 removal from chromatin	47	2.60e-01	-0.095100	0.82300
Oncogenic MAPK signaling	60	2.03e-01	-0.095100	0.78500
FRS-mediated FGFR1 signaling	18	4.86e-01	0.094800	0.90700
SRP-dependent cotranslational protein targeting to membrane	48	2.57e-01	0.094500	0.82100
MAP3K8 (TPL2)-dependent MAPK1/3 activation	11	5.88e-01	0.094500	0.91400
Regulation of RUNX2 expression and activity	47	2.64e-01	-0.094200	0.82600
Major pathway of rRNA processing in the nucleolus and cytosol	97	1.10e-01	0.094000	0.76400
Uptake and function of anthrax toxins	11	5.91e-01	-0.093500	0.91400
Signaling by the B Cell Receptor (BCR)	79	1.53e-01	-0.093100	0.77600
DNA Replication	93	1.21e-01	-0.093100	0.77600
RAB geranylgeranylation	40	3.10e-01	-0.092800	0.87500
EML4 and NUDC in mitotic spindle formation	71	1.77e-01	-0.092800	0.77600
ABC-family proteins mediated transport	70	1.81e-01	-0.092500	0.77600
Regulation of activated PAK-2p34 by proteasome mediated degradation	33	3.59e-01	-0.092400	0.90700
Chaperonin-mediated protein folding	71	1.79e-01	0.092300	0.77600
mRNA 3'-end processing	39	3.20e-01	-0.092200	0.88600
FRS-mediated FGFR2 signaling	19	4.87e-01	0.092100	0.90700
Signaling by SCF-KIT	34	3.54e-01	0.091900	0.90300
Influenza Infection	74	1.72e-01	-0.091900	0.77600
Degradation of DVL	37	3.34e-01	-0.091700	0.89200
Adrenaline,noradrenaline inhibits insulin secretion	22	4.58e-01	0.091500	0.90700
Regulation of cholesterol biosynthesis by SREBP (SREBF)	45	2.89e-01	-0.091500	0.84900
Regulation of lipid metabolism by PPARalpha	97	1.21e-01	-0.091300	0.77600
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	5.69e-01	0.091200	0.91200
Activation of ATR in response to replication stress	23	4.52e-01	-0.090500	0.90700
GABA receptor activation	44	3.00e-01	0.090300	0.86300
Cell Cycle	452	1.09e-03	-0.090200	0.25300
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	13	5.74e-01	0.090100	0.91200
Diseases of hemostasis	13	5.74e-01	0.090100	0.91200
The role of GTSE1 in G2/M progression after G2 checkpoint	40	3.25e-01	-0.090000	0.89200
Nuclear import of Rev protein	23	4.55e-01	-0.090000	0.90700
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	13	5.75e-01	-0.089900	0.91200
Signaling by Ligand-Responsive EGFR Variants in Cancer	13	5.75e-01	-0.089900	0.91200
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	10	6.28e-01	0.088600	0.93100
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	5.53e-01	-0.088500	0.90700
Regulation of TP53 Activity through Phosphorylation	66	2.15e-01	-0.088400	0.79400
cGMP effects	16	5.40e-01	0.088400	0.90700
Ovarian tumor domain proteases	27	4.29e-01	-0.088000	0.90700
M Phase	262	1.46e-02	-0.088000	0.41500
FGFR4 ligand binding and activation	11	6.14e-01	0.087900	0.92900
Signaling by Retinoic Acid	38	3.50e-01	0.087700	0.90100
RNA Polymerase III Transcription Termination	15	5.57e-01	0.087600	0.90700
PPARA activates gene expression	95	1.41e-01	-0.087500	0.77600
RORA activates gene expression	16	5.45e-01	-0.087400	0.90700
Interaction between L1 and Ankyrins	27	4.32e-01	0.087400	0.90700
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	13	5.86e-01	0.087300	0.91400
Signaling by NTRK2 (TRKB)	20	5.00e-01	0.087200	0.90700
Downstream signaling of activated FGFR4	21	4.90e-01	0.087000	0.90700
Centrosome maturation	65	2.28e-01	-0.086500	0.79900
Recruitment of mitotic centrosome proteins and complexes	65	2.28e-01	-0.086500	0.79900
Integration of energy metabolism	93	1.52e-01	0.086000	0.77600
Amyloid fiber formation	35	3.80e-01	0.085800	0.90700
The NLRP3 inflammasome	11	6.22e-01	-0.085800	0.93100
Initial triggering of complement	23	4.77e-01	-0.085700	0.90700
Attenuation phase	16	5.55e-01	-0.085300	0.90700
Gamma carboxylation, hypusine formation and arylsulfatase activation	24	4.70e-01	-0.085300	0.90700
Transport of inorganic cations/anions and amino acids/oligopeptides	89	1.66e-01	0.085000	0.77600
Hyaluronan metabolism	11	6.26e-01	0.084900	0.93100
Regulation of Apoptosis	35	3.85e-01	-0.084900	0.90700
Resolution of Sister Chromatid Cohesion	77	1.99e-01	-0.084800	0.77600
Sialic acid metabolism	27	4.47e-01	0.084600	0.90700
Glutamate and glutamine metabolism	13	5.99e-01	0.084300	0.91900
Ubiquitin-dependent degradation of Cyclin D	35	3.89e-01	-0.084200	0.90700
Diseases associated with glycosaminoglycan metabolism	33	4.04e-01	-0.084000	0.90700
Acyl chain remodelling of PI	14	5.86e-01	0.084000	0.91400
Transport of bile salts and organic acids, metal ions and amine compounds	66	2.40e-01	0.083700	0.80600
Interleukin-17 signaling	57	2.75e-01	0.083700	0.84000
Vpu mediated degradation of CD4	34	3.99e-01	-0.083700	0.90700
PIWI-interacting RNA (piRNA) biogenesis	18	5.39e-01	0.083600	0.90700
Diseases of carbohydrate metabolism	25	4.71e-01	0.083400	0.90700
NOTCH3 Intracellular Domain Regulates Transcription	22	4.99e-01	-0.083200	0.90700
Transcriptional regulation by RUNX2	80	2.00e-01	-0.083000	0.77600
HCMV Early Events	44	3.44e-01	-0.082500	0.90000
Removal of the Flap Intermediate	11	6.36e-01	-0.082400	0.93600
Adenylate cyclase inhibitory pathway	13	6.08e-01	0.082300	0.92500
APC/C-mediated degradation of cell cycle proteins	65	2.52e-01	-0.082200	0.81300
Regulation of mitotic cell cycle	65	2.52e-01	-0.082200	0.81300
Processing of Capped Intronless Pre-mRNA	17	5.58e-01	-0.082200	0.90700
Voltage gated Potassium channels	31	4.29e-01	-0.082100	0.90700
Telomere C-strand synthesis initiation	11	6.38e-01	0.081800	0.93600
Response of Mtb to phagocytosis	18	5.48e-01	0.081800	0.90700
Apoptosis	129	1.10e-01	-0.081600	0.76400
mRNA Splicing	124	1.18e-01	-0.081500	0.77600
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	26	4.74e-01	0.081200	0.90700
Processing of Capped Intron-Containing Pre-mRNA	161	7.66e-02	-0.081100	0.68300
Recruitment of NuMA to mitotic centrosomes	64	2.63e-01	-0.081000	0.82600
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	19	5.42e-01	0.080900	0.90700
CTLA4 inhibitory signaling	18	5.53e-01	-0.080800	0.90700
Defective B4GALT7 causes EDS, progeroid type	15	5.88e-01	-0.080700	0.91400
Carnitine metabolism	11	6.43e-01	-0.080700	0.93800
FOXO-mediated transcription	55	3.01e-01	0.080700	0.86300
Response of EIF2AK4 (GCN2) to amino acid deficiency	38	3.90e-01	0.080700	0.90700
Interleukin-37 signaling	15	5.89e-01	0.080600	0.91400
Cell-Cell communication	96	1.73e-01	-0.080600	0.77600
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	31	4.38e-01	0.080500	0.90700
Synthesis of PIPs at the plasma membrane	48	3.35e-01	0.080500	0.89200
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	11	6.44e-01	-0.080500	0.93800
Sphingolipid metabolism	63	2.71e-01	-0.080200	0.83800
Erythropoietin activates RAS	10	6.61e-01	-0.080000	0.93900
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	13	6.18e-01	0.079800	0.92900
Pyruvate metabolism	23	5.08e-01	-0.079800	0.90700
Nitric oxide stimulates guanylate cyclase	21	5.29e-01	-0.079500	0.90700
Signaling by FGFR in disease	45	3.58e-01	0.079300	0.90700
Transcriptional regulation by small RNAs	29	4.62e-01	-0.079000	0.90700
Vpr-mediated nuclear import of PICs	23	5.13e-01	-0.078900	0.90700
Spry regulation of FGF signaling	11	6.51e-01	-0.078800	0.93800
EGR2 and SOX10-mediated initiation of Schwann cell myelination	25	4.97e-01	-0.078600	0.90700
Protein folding	77	2.37e-01	0.078100	0.80600
Transport of Mature mRNA Derived from an Intronless Transcript	28	4.75e-01	-0.078000	0.90700
Cellular hexose transport	19	5.56e-01	0.078000	0.90700
Regulation of IFNG signaling	10	6.70e-01	-0.077900	0.94200
Myogenesis	27	4.84e-01	-0.077800	0.90700
Cargo concentration in the ER	21	5.38e-01	-0.077600	0.90700
SUMOylation	126	1.34e-01	-0.077500	0.77600
Protein ubiquitination	38	4.09e-01	0.077400	0.90700
TCR signaling	81	2.30e-01	-0.077300	0.79900
Signaling by WNT	204	5.79e-02	0.077200	0.66300
Ephrin signaling	17	5.82e-01	0.077200	0.91400
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	36	4.24e-01	-0.077000	0.90700
Hemostasis	460	4.98e-03	-0.076900	0.39400
Signaling by PDGFR in disease	17	5.84e-01	0.076700	0.91400
Metal ion SLC transporters	19	5.63e-01	-0.076700	0.91000
rRNA processing	110	1.65e-01	0.076700	0.77600
Clathrin-mediated endocytosis	106	1.73e-01	-0.076700	0.77600
DNA Damage Bypass	30	4.69e-01	0.076500	0.90700
NR1H2 and NR1H3-mediated signaling	40	4.07e-01	0.075900	0.90700
GTP hydrolysis and joining of the 60S ribosomal subunit	44	3.85e-01	0.075700	0.90700
Activation of RAC1	10	6.80e-01	-0.075300	0.94200
Platelet Aggregation (Plug Formation)	33	4.55e-01	0.075200	0.90700
Glutathione conjugation	29	4.84e-01	-0.075100	0.90700
Cell Cycle, Mitotic	361	1.47e-02	-0.075100	0.41500
Signaling by VEGF	88	2.25e-01	-0.074900	0.79900
Ub-specific processing proteases	125	1.49e-01	-0.074800	0.77600
DAP12 signaling	20	5.63e-01	-0.074600	0.91000
The phototransduction cascade	24	5.29e-01	0.074300	0.90700
Surfactant metabolism	19	5.76e-01	-0.074200	0.91300
Transport of organic anions	11	6.71e-01	-0.073900	0.94200
Interactions of Vpr with host cellular proteins	25	5.23e-01	-0.073900	0.90700
rRNA processing in the nucleus and cytosol	103	1.96e-01	0.073800	0.77600
HCMV Infection	59	3.27e-01	-0.073800	0.89200
Plasma lipoprotein assembly, remodeling, and clearance	55	3.45e-01	-0.073700	0.90000
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	6.58e-01	-0.073700	0.93800
Interleukin-7 signaling	14	6.34e-01	0.073400	0.93600
MET promotes cell motility	26	5.18e-01	0.073200	0.90700
Host Interactions of HIV factors	89	2.33e-01	-0.073200	0.80300
SLC-mediated transmembrane transport	206	7.13e-02	0.073100	0.68000
G beta:gamma signalling through CDC42	13	6.49e-01	-0.072900	0.93800
Chromosome Maintenance	57	3.42e-01	-0.072800	0.90000
RNA Polymerase III Transcription Initiation From Type 1 Promoter	17	6.03e-01	-0.072800	0.92300
Telomere C-strand (Lagging Strand) Synthesis	25	5.30e-01	0.072700	0.90700
Activation of AMPK downstream of NMDARs	10	6.91e-01	-0.072600	0.94200
Acyl chain remodelling of PE	19	5.84e-01	0.072600	0.91400
Translocation of SLC2A4 (GLUT4) to the plasma membrane	44	4.06e-01	0.072400	0.90700
Mitotic Prometaphase	140	1.40e-01	-0.072400	0.77600
Selenocysteine synthesis	35	4.60e-01	0.072200	0.90700
Transcriptional Regulation by E2F6	27	5.17e-01	-0.072100	0.90700
Deadenylation-dependent mRNA decay	38	4.42e-01	0.072100	0.90700
Frs2-mediated activation	10	6.93e-01	0.072000	0.94200
Viral mRNA Translation	33	4.76e-01	0.071800	0.90700
HATs acetylate histones	58	3.46e-01	-0.071600	0.90000
Mitotic G2-G2/M phases	129	1.66e-01	-0.070800	0.77600
Downstream signaling of activated FGFR2	24	5.49e-01	0.070700	0.90700
Downregulation of TGF-beta receptor signaling	17	6.14e-01	-0.070600	0.92900
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	22	5.67e-01	-0.070500	0.91100
Presynaptic function of Kainate receptors	15	6.37e-01	-0.070500	0.93600
Programmed Cell Death	132	1.63e-01	-0.070500	0.77600
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	5.59e-01	-0.070400	0.90700
Class B/2 (Secretin family receptors)	69	3.15e-01	0.070000	0.88300
TBC/RABGAPs	33	4.88e-01	-0.069900	0.90700
SUMO E3 ligases SUMOylate target proteins	121	1.87e-01	-0.069600	0.77600
Sema3A PAK dependent Axon repulsion	12	6.77e-01	0.069500	0.94200
G2/M Transition	127	1.78e-01	-0.069400	0.77600
Hedgehog 'off' state	72	3.10e-01	0.069300	0.87500
DARPP-32 events	20	5.93e-01	0.069000	0.91500
NOD1/2 Signaling Pathway	25	5.51e-01	0.069000	0.90700
Regulation of APC/C activators between G1/S and early anaphase	58	3.65e-01	-0.068800	0.90700
Hedgehog 'on' state	55	3.79e-01	-0.068700	0.90700
Activation of BH3-only proteins	26	5.48e-01	-0.068200	0.90700
CS/DS degradation	11	6.96e-01	-0.068000	0.94200
Degradation of GLI1 by the proteasome	38	4.69e-01	-0.067900	0.90700
Generation of second messenger molecules	22	5.82e-01	-0.067800	0.91400
Signaling by MET	54	3.90e-01	-0.067700	0.90700
Neutrophil degranulation	335	3.41e-02	-0.067700	0.49900
Downstream signaling of activated FGFR1	26	5.51e-01	0.067600	0.90700
O-linked glycosylation of mucins	48	4.19e-01	0.067500	0.90700
Beta defensins	19	6.13e-01	0.067000	0.92900
Signaling by high-kinase activity BRAF mutants	26	5.57e-01	-0.066600	0.90700
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	6.92e-01	-0.066100	0.94200
Amino acid transport across the plasma membrane	28	5.45e-01	-0.066000	0.90700
Intrinsic Pathway for Apoptosis	41	4.66e-01	-0.065900	0.90700
Signaling by BRAF and RAF fusions	48	4.31e-01	-0.065800	0.90700
Signaling by ROBO receptors	122	2.12e-01	-0.065500	0.79400
SCF-beta-TrCP mediated degradation of Emi1	37	4.91e-01	-0.065400	0.90700
Membrane Trafficking	463	1.66e-02	-0.065400	0.41500
Inactivation, recovery and regulation of the phototransduction cascade	23	5.87e-01	0.065400	0.91400
Interleukin-15 signaling	11	7.08e-01	0.065200	0.94300
Downstream TCR signaling	64	3.69e-01	-0.065000	0.90700
YAP1- and WWTR1 (TAZ)-stimulated gene expression	12	6.98e-01	-0.064700	0.94200
HSF1 activation	19	6.25e-01	0.064700	0.93100
MAP kinase activation	51	4.25e-01	0.064600	0.90700
Vesicle-mediated transport	493	1.51e-02	-0.064400	0.41500
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	41	4.78e-01	0.064100	0.90700
Signaling by FGFR3 in disease	17	6.47e-01	0.064100	0.93800
Signaling by FGFR3 point mutants in cancer	17	6.47e-01	0.064100	0.93800
Formation of TC-NER Pre-Incision Complex	32	5.31e-01	-0.064000	0.90700
Regulation of ornithine decarboxylase (ODC)	35	5.13e-01	-0.064000	0.90700
Paradoxical activation of RAF signaling by kinase inactive BRAF	33	5.26e-01	-0.063800	0.90700
Signaling by RAS mutants	33	5.26e-01	-0.063800	0.90700
Signaling by moderate kinase activity BRAF mutants	33	5.26e-01	-0.063800	0.90700
Signaling downstream of RAS mutants	33	5.26e-01	-0.063800	0.90700
ISG15 antiviral mechanism	48	4.46e-01	-0.063600	0.90700
Transport of vitamins, nucleosides, and related molecules	36	5.10e-01	0.063500	0.90700
RHO GTPase Effectors	191	1.32e-01	-0.063400	0.77600
Sealing of the nuclear envelope (NE) by ESCRT-III	24	5.91e-01	-0.063400	0.91400
PI-3K cascade:FGFR3	15	6.72e-01	0.063100	0.94200
Fcgamma receptor (FCGR) dependent phagocytosis	76	3.43e-01	-0.063000	0.90000
Scavenging of heme from plasma	10	7.30e-01	0.062900	0.95400
Rev-mediated nuclear export of HIV RNA	24	5.94e-01	-0.062900	0.91500
B-WICH complex positively regulates rRNA expression	21	6.19e-01	-0.062700	0.92900
Transcriptional Regulation by MECP2	48	4.56e-01	0.062200	0.90700
tRNA processing in the nucleus	42	4.86e-01	-0.062100	0.90700
RHO GTPases Activate WASPs and WAVEs	30	5.57e-01	-0.062000	0.90700
EPH-Ephrin signaling	73	3.62e-01	-0.061700	0.90700
Gluconeogenesis	27	5.79e-01	0.061700	0.91400
PI3K Cascade	38	5.13e-01	0.061300	0.90700
Interleukin-2 family signaling	31	5.56e-01	0.061100	0.90700
FGFR1 ligand binding and activation	13	7.03e-01	0.061100	0.94200
SUMOylation of DNA damage response and repair proteins	49	4.61e-01	-0.060900	0.90700
C-type lectin receptors (CLRs)	96	3.04e-01	-0.060800	0.86800
Signaling by Interleukins	322	6.24e-02	0.060700	0.66300
Visual phototransduction	74	3.68e-01	0.060600	0.90700
L13a-mediated translational silencing of Ceruloplasmin expression	43	4.92e-01	0.060600	0.90700
Mismatch Repair	13	7.05e-01	0.060600	0.94200
SUMOylation of transcription cofactors	32	5.55e-01	-0.060300	0.90700
Base Excision Repair	36	5.32e-01	0.060200	0.90700
Apoptotic execution phase	37	5.27e-01	-0.060100	0.90700
Signaling by Nuclear Receptors	191	1.53e-01	-0.060100	0.77600
Constitutive Signaling by AKT1 E17K in Cancer	21	6.35e-01	-0.059900	0.93600
Activated point mutants of FGFR2	14	6.98e-01	0.059800	0.94200
SCF(Skp2)-mediated degradation of p27/p21	40	5.14e-01	-0.059700	0.90700
Synthesis of PIPs at the Golgi membrane	14	6.99e-01	-0.059700	0.94200
STING mediated induction of host immune responses	11	7.32e-01	-0.059600	0.95400
SUMOylation of intracellular receptors	25	6.07e-01	0.059400	0.92500
Nuclear Envelope Breakdown	38	5.28e-01	0.059100	0.90700
Signaling by TGFB family members	76	3.75e-01	-0.058900	0.90700
Postmitotic nuclear pore complex (NPC) reformation	20	6.49e-01	-0.058800	0.93800
TNFs bind their physiological receptors	20	6.50e-01	-0.058700	0.93800
A tetrasaccharide linker sequence is required for GAG synthesis	20	6.50e-01	-0.058700	0.93800
Adaptive Immune System	517	2.35e-02	-0.058600	0.43600
Tryptophan catabolism	12	7.25e-01	-0.058600	0.95300
RNA Polymerase III Transcription Initiation From Type 2 Promoter	16	6.85e-01	-0.058600	0.94200
Regulation of TP53 Activity through Methylation	11	7.37e-01	-0.058600	0.95500
MyD88 dependent cascade initiated on endosome	70	3.98e-01	0.058500	0.90700
Toll Like Receptor 7/8 (TLR7/8) Cascade	70	3.98e-01	0.058500	0.90700
VEGFA-VEGFR2 Pathway	83	3.60e-01	-0.058200	0.90700
Muscle contraction	169	1.94e-01	0.058000	0.77600
MAP2K and MAPK activation	28	5.95e-01	-0.058000	0.91600
Regulation of KIT signaling	10	7.51e-01	0.058000	0.95700
Nucleotide Excision Repair	75	3.87e-01	0.057900	0.90700
Binding and Uptake of Ligands by Scavenger Receptors	32	5.72e-01	-0.057700	0.91200
Ethanol oxidation	10	7.54e-01	-0.057300	0.95700
Interleukin receptor SHC signaling	19	6.66e-01	0.057200	0.94200
Transcriptional regulation of white adipocyte differentiation	66	4.23e-01	-0.057100	0.90700
Cell death signalling via NRAGE, NRIF and NADE	62	4.39e-01	0.056900	0.90700
Mitochondrial tRNA aminoacylation	12	7.33e-01	-0.056900	0.95400
MyD88 cascade initiated on plasma membrane	65	4.28e-01	0.056900	0.90700
Toll Like Receptor 10 (TLR10) Cascade	65	4.28e-01	0.056900	0.90700
Toll Like Receptor 5 (TLR5) Cascade	65	4.28e-01	0.056900	0.90700
FCGR3A-mediated IL10 synthesis	37	5.50e-01	0.056800	0.90700
Mitochondrial Fatty Acid Beta-Oxidation	27	6.10e-01	-0.056800	0.92800
Activation of BAD and translocation to mitochondria	13	7.24e-01	0.056600	0.95300
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	7.34e-01	0.056600	0.95400
Oxidative Stress Induced Senescence	53	4.79e-01	-0.056300	0.90700
Inflammasomes	16	6.97e-01	0.056200	0.94200
Ion transport by P-type ATPases	42	5.29e-01	0.056200	0.90700
Antiviral mechanism by IFN-stimulated genes	54	4.76e-01	-0.056200	0.90700
Synthesis of substrates in N-glycan biosythesis	51	4.88e-01	0.056100	0.90700
Synthesis of very long-chain fatty acyl-CoAs	19	6.72e-01	-0.056100	0.94200
PD-1 signaling	12	7.37e-01	-0.056000	0.95500
Amino acids regulate mTORC1	36	5.62e-01	-0.055900	0.91000
Diseases associated with visual transduction	11	7.49e-01	0.055700	0.95700
Diseases of the neuronal system	11	7.49e-01	0.055700	0.95700
Retinoid cycle disease events	11	7.49e-01	0.055700	0.95700
Collagen formation	69	4.25e-01	0.055600	0.90700
Toll Like Receptor 9 (TLR9) Cascade	72	4.16e-01	0.055500	0.90700
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	63	4.47e-01	0.055500	0.90700
Collagen biosynthesis and modifying enzymes	53	4.89e-01	0.055000	0.90700
Condensation of Prophase Chromosomes	10	7.64e-01	0.054900	0.95700
Cap-dependent Translation Initiation	50	5.04e-01	0.054600	0.90700
Eukaryotic Translation Initiation	50	5.04e-01	0.054600	0.90700
Fertilization	20	6.73e-01	-0.054600	0.94200
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	30	6.06e-01	0.054400	0.92500
Innate Immune System	736	1.29e-02	-0.054400	0.41500
Detoxification of Reactive Oxygen Species	23	6.53e-01	-0.054200	0.93800
Post NMDA receptor activation events	52	5.00e-01	0.054100	0.90700
Fatty acyl-CoA biosynthesis	27	6.29e-01	0.053800	0.93200
Unfolded Protein Response (UPR)	67	4.47e-01	0.053800	0.90700
Cyclin D associated events in G1	32	6.02e-01	-0.053300	0.92200
G1 Phase	32	6.02e-01	-0.053300	0.92200
Intraflagellar transport	35	5.85e-01	-0.053300	0.91400
E3 ubiquitin ligases ubiquitinate target proteins	23	6.59e-01	0.053100	0.93800
IKK complex recruitment mediated by RIP1	16	7.13e-01	0.053100	0.94800
Formation of a pool of free 40S subunits	39	5.67e-01	0.053100	0.91100
Caspase-mediated cleavage of cytoskeletal proteins	10	7.72e-01	0.053000	0.95700
tRNA processing	76	4.25e-01	-0.052900	0.90700
Degradation of cysteine and homocysteine	11	7.62e-01	0.052800	0.95700
Non-integrin membrane-ECM interactions	35	5.90e-01	0.052700	0.91400
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	21	6.77e-01	-0.052500	0.94200
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	50	5.22e-01	0.052400	0.90700
Nonsense-Mediated Decay (NMD)	50	5.22e-01	0.052400	0.90700
Glycogen storage diseases	11	7.64e-01	0.052400	0.95700
Aggrephagy	18	7.01e-01	-0.052300	0.94200
Semaphorin interactions	54	5.07e-01	0.052300	0.90700
Smooth Muscle Contraction	29	6.27e-01	0.052200	0.93100
UCH proteinases	60	4.86e-01	0.052000	0.90700
DNA strand elongation	23	6.68e-01	-0.051700	0.94200
Neurexins and neuroligins	49	5.33e-01	0.051500	0.90700
Translation of structural proteins	19	6.98e-01	0.051400	0.94200
Infectious disease	510	4.87e-02	-0.051300	0.62700
Synaptic adhesion-like molecules	18	7.06e-01	-0.051300	0.94200
Regulation of MECP2 expression and activity	23	6.71e-01	0.051100	0.94200
SUMOylation of ubiquitinylation proteins	25	6.59e-01	-0.051100	0.93800
Regulation of mRNA stability by proteins that bind AU-rich elements	60	4.94e-01	-0.051000	0.90700
Sema4D induced cell migration and growth-cone collapse	16	7.24e-01	-0.050900	0.95300
Platelet sensitization by LDL	15	7.33e-01	-0.050800	0.95400
Cyclin A:Cdk2-associated events at S phase entry	58	5.05e-01	-0.050700	0.90700
Cytosolic sulfonation of small molecules	17	7.18e-01	-0.050600	0.95100
Transcriptional regulation of granulopoiesis	29	6.38e-01	0.050500	0.93600
Nuclear Envelope (NE) Reassembly	57	5.11e-01	-0.050400	0.90700
Infection with Mycobacterium tuberculosis	21	6.89e-01	0.050400	0.94200
IRS-mediated signalling	40	5.82e-01	0.050300	0.91400
Phase 2 - plateau phase	20	6.98e-01	0.050200	0.94200
Cardiac conduction	113	3.61e-01	0.049800	0.90700
Activation of HOX genes during differentiation	40	5.86e-01	0.049800	0.91400
Activation of anterior HOX genes in hindbrain development during early embryogenesis	40	5.86e-01	0.049800	0.91400
RNA Polymerase III Transcription Initiation	23	6.82e-01	-0.049400	0.94200
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	62	5.02e-01	0.049300	0.90700
Signal amplification	24	6.78e-01	0.049000	0.94200
Anchoring of the basal body to the plasma membrane	75	4.65e-01	-0.048900	0.90700
Apoptotic cleavage of cell adhesion proteins	10	7.90e-01	0.048500	0.95900
Nicotinate metabolism	20	7.07e-01	-0.048500	0.94300
Cell-cell junction organization	45	5.74e-01	-0.048400	0.91200
RHO GTPases Activate Formins	88	4.34e-01	-0.048300	0.90700
Death Receptor Signalling	113	3.77e-01	-0.048200	0.90700
Dual incision in TC-NER	43	5.87e-01	-0.048000	0.91400
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	7.65e-01	-0.047800	0.95700
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	69	4.93e-01	0.047800	0.90700
Export of Viral Ribonucleoproteins from Nucleus	23	6.92e-01	-0.047700	0.94200
Elastic fibre formation	33	6.36e-01	0.047600	0.93600
The citric acid (TCA) cycle and respiratory electron transport	99	4.14e-01	-0.047600	0.90700
Integrin cell surface interactions	56	5.39e-01	0.047500	0.90700
Interconversion of nucleotide di- and triphosphates	22	7.00e-01	0.047500	0.94200
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	12	7.77e-01	-0.047200	0.95900
Negative regulation of MAPK pathway	33	6.39e-01	0.047200	0.93600
SUMOylation of SUMOylation proteins	22	7.03e-01	-0.047100	0.94200
CLEC7A (Dectin-1) induces NFAT activation	10	7.97e-01	0.046900	0.96200
FCGR3A-mediated phagocytosis	55	5.50e-01	-0.046600	0.90700
Leishmania phagocytosis	55	5.50e-01	-0.046600	0.90700
Parasite infection	55	5.50e-01	-0.046600	0.90700
Insulin receptor recycling	15	7.55e-01	0.046600	0.95700
Plasma lipoprotein remodeling	24	6.95e-01	-0.046300	0.94200
TICAM1, RIP1-mediated IKK complex recruitment	13	7.73e-01	0.046200	0.95700
Metabolism of polyamines	41	6.10e-01	-0.046000	0.92800
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	7.83e-01	-0.046000	0.95900
Mitochondrial biogenesis	61	5.35e-01	-0.046000	0.90700
Class I MHC mediated antigen processing & presentation	265	1.99e-01	-0.046000	0.77600
Transmission across Chemical Synapses	193	2.73e-01	0.045900	0.84000
Dual Incision in GG-NER	31	6.60e-01	0.045700	0.93800
Cell junction organization	67	5.18e-01	-0.045700	0.90700
Fanconi Anemia Pathway	23	7.05e-01	0.045600	0.94200
Negative regulation of FGFR4 signaling	23	7.05e-01	0.045600	0.94200
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	73	5.04e-01	0.045300	0.90700
Toll Like Receptor 2 (TLR2) Cascade	73	5.04e-01	0.045300	0.90700
Toll Like Receptor TLR1:TLR2 Cascade	73	5.04e-01	0.045300	0.90700
Toll Like Receptor TLR6:TLR2 Cascade	73	5.04e-01	0.045300	0.90700
CRMPs in Sema3A signaling	14	7.70e-01	0.045200	0.95700
RMTs methylate histone arginines	26	6.91e-01	0.045100	0.94200
Peptide hormone metabolism	62	5.42e-01	0.044800	0.90700
Glucagon-type ligand receptors	25	6.98e-01	0.044800	0.94200
Association of TriC/CCT with target proteins during biosynthesis	30	6.71e-01	0.044800	0.94200
Energy dependent regulation of mTOR by LKB1-AMPK	21	7.23e-01	-0.044600	0.95300
Processing of Intronless Pre-mRNAs	11	7.98e-01	0.044600	0.96200
Free fatty acids regulate insulin secretion	11	7.99e-01	-0.044400	0.96200
Reproduction	65	5.36e-01	-0.044400	0.90700
RNA Polymerase III Chain Elongation	11	8.01e-01	0.044000	0.96200
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	53	5.80e-01	-0.043900	0.91400
Netrin-1 signaling	41	6.27e-01	0.043900	0.93100
Post-translational protein phosphorylation	79	5.04e-01	0.043600	0.90700
Acetylcholine Neurotransmitter Release Cycle	11	8.03e-01	0.043300	0.96300
IRS-related events triggered by IGF1R	43	6.23e-01	0.043300	0.93100
Telomere Maintenance	43	6.24e-01	0.043200	0.93100
Purine catabolism	14	7.80e-01	-0.043100	0.95900
Organelle biogenesis and maintenance	207	2.87e-01	-0.043100	0.84900
PCP/CE pathway	65	5.49e-01	-0.043000	0.90700
HCMV Late Events	37	6.52e-01	-0.042900	0.93800
SUMOylation of chromatin organization proteins	39	6.45e-01	-0.042700	0.93800
Insulin receptor signalling cascade	46	6.17e-01	0.042600	0.92900
MET activates PTK2 signaling	16	7.69e-01	0.042500	0.95700
Peptide ligand-binding receptors	150	3.71e-01	-0.042400	0.90700
Plasma lipoprotein clearance	29	6.93e-01	-0.042300	0.94200
Synthesis of PIPs at the early endosome membrane	14	7.84e-01	0.042300	0.95900
Initiation of Nuclear Envelope (NE) Reformation	15	7.78e-01	-0.042100	0.95900
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	7.71e-01	-0.042100	0.95700
ECM proteoglycans	47	6.19e-01	-0.042000	0.92900
Cilium Assembly	146	3.88e-01	-0.041400	0.90700
SUMOylation of DNA replication proteins	32	6.85e-01	-0.041400	0.94200
RUNX2 regulates bone development	24	7.26e-01	0.041400	0.95300
Signaling by ERBB2 ECD mutants	13	7.97e-01	-0.041300	0.96200
Heme degradation	15	7.82e-01	0.041200	0.95900
Interleukin-10 signaling	34	6.80e-01	0.040900	0.94200
Antigen processing: Ubiquitination & Proteasome degradation	225	2.98e-01	-0.040400	0.86300
Platelet homeostasis	71	5.58e-01	-0.040200	0.90700
PTEN Regulation	104	4.80e-01	-0.040100	0.90700
Ion homeostasis	41	6.57e-01	0.040100	0.93800
Meiosis	45	6.45e-01	-0.039800	0.93800
ADP signalling through P2Y purinoceptor 12	15	7.91e-01	-0.039600	0.95900
Keratan sulfate biosynthesis	21	7.54e-01	0.039600	0.95700
TP53 Regulates Transcription of Cell Cycle Genes	39	6.75e-01	0.038900	0.94200
Bile acid and bile salt metabolism	32	7.05e-01	0.038700	0.94200
Nucleobase catabolism	27	7.28e-01	-0.038700	0.95400
FGFR2 ligand binding and activation	16	7.89e-01	0.038600	0.95900
Signaling by Receptor Tyrosine Kinases	388	1.96e-01	-0.038400	0.77600
Regulation of RUNX1 Expression and Activity	14	8.04e-01	0.038200	0.96300
Rab regulation of trafficking	91	5.31e-01	-0.038000	0.90700
Gap-filling DNA repair synthesis and ligation in GG-NER	18	7.81e-01	0.037900	0.95900
Carboxyterminal post-translational modifications of tubulin	32	7.12e-01	0.037800	0.94700
Rho GTPase cycle	116	4.84e-01	0.037700	0.90700
Cholesterol biosynthesis	16	7.95e-01	-0.037600	0.96200
Neurotransmitter receptors and postsynaptic signal transmission	146	4.34e-01	0.037600	0.90700
Transcriptional Regulation by VENTX	32	7.14e-01	-0.037500	0.94800
O-linked glycosylation	85	5.51e-01	0.037400	0.90700
Digestion and absorption	21	7.67e-01	-0.037400	0.95700
GABA synthesis, release, reuptake and degradation	13	8.16e-01	-0.037300	0.97000
Termination of translesion DNA synthesis	21	7.68e-01	0.037200	0.95700
CD28 dependent Vav1 pathway	11	8.32e-01	-0.036900	0.97000
DNA Repair	197	3.75e-01	-0.036800	0.90700
Signaling by NODAL	18	7.89e-01	0.036400	0.95900
NRAGE signals death through JNK	53	6.47e-01	0.036400	0.93800
Translocation of ZAP-70 to Immunological synapse	11	8.35e-01	0.036400	0.97000
Regulation of PLK1 Activity at G2/M Transition	63	6.19e-01	0.036300	0.92900
RNA Polymerase III Transcription Initiation From Type 3 Promoter	19	7.84e-01	0.036300	0.95900
Neuronal System	305	2.80e-01	0.036200	0.84500
Interleukin-1 signaling	72	5.99e-01	-0.035900	0.91900
EPH-ephrin mediated repulsion of cells	39	7.00e-01	-0.035700	0.94200
Cellular responses to external stimuli	340	2.61e-01	-0.035600	0.82400
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	11	8.38e-01	0.035600	0.97000
SARS-CoV Infections	58	6.39e-01	-0.035600	0.93600
Toll Like Receptor 4 (TLR4) Cascade	100	5.39e-01	0.035600	0.90700
Negative regulation of FGFR2 signaling	26	7.55e-01	0.035400	0.95700
VEGFR2 mediated cell proliferation	18	7.95e-01	0.035400	0.96200
Negative regulation of FGFR1 signaling	25	7.62e-01	0.035000	0.95700
Glycerophospholipid biosynthesis	91	5.70e-01	0.034500	0.91200
Metabolism of RNA	434	2.25e-01	-0.034200	0.79900
RIPK1-mediated regulated necrosis	14	8.25e-01	-0.034100	0.97000
Regulated Necrosis	14	8.25e-01	-0.034100	0.97000
NGF-stimulated transcription	32	7.39e-01	0.034100	0.95500
ABC transporter disorders	52	6.71e-01	-0.034100	0.94200
Signaling by Insulin receptor	59	6.53e-01	0.033800	0.93800
Acyl chain remodelling of PC	21	7.89e-01	0.033700	0.95900
Metabolism of steroids	118	5.31e-01	-0.033400	0.90700
Misspliced GSK3beta mutants stabilize beta-catenin	13	8.35e-01	0.033400	0.97000
S33 mutants of beta-catenin aren't phosphorylated	13	8.35e-01	0.033400	0.97000
S37 mutants of beta-catenin aren't phosphorylated	13	8.35e-01	0.033400	0.97000
S45 mutants of beta-catenin aren't phosphorylated	13	8.35e-01	0.033400	0.97000
T41 mutants of beta-catenin aren't phosphorylated	13	8.35e-01	0.033400	0.97000
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	13	8.35e-01	0.033400	0.97000
RUNX2 regulates osteoblast differentiation	18	8.07e-01	0.033300	0.96400
Metabolism of nucleotides	76	6.17e-01	-0.033200	0.92900
Metabolism of porphyrins	24	7.78e-01	0.033200	0.95900
Signaling by NTRKs	114	5.45e-01	0.032800	0.90700
Regulation of signaling by NODAL	10	8.58e-01	0.032700	0.97200
Mitotic Prophase	62	6.57e-01	0.032600	0.93800
Collagen degradation	33	7.46e-01	0.032600	0.95700
Mitotic G1 phase and G1/S transition	104	5.67e-01	-0.032600	0.91100
Incretin synthesis, secretion, and inactivation	16	8.23e-01	-0.032200	0.97000
Post-translational modification: synthesis of GPI-anchored proteins	64	6.56e-01	0.032200	0.93800
Scavenging by Class A Receptors	13	8.41e-01	-0.032100	0.97000
Chondroitin sulfate/dermatan sulfate metabolism	42	7.24e-01	-0.031500	0.95300
EPHA-mediated growth cone collapse	12	8.50e-01	0.031500	0.97000
GPVI-mediated activation cascade	25	7.86e-01	-0.031400	0.95900
Signaling by FGFR1	39	7.34e-01	-0.031400	0.95400
Dectin-2 family	15	8.33e-01	0.031400	0.97000
AMER1 mutants destabilize the destruction complex	12	8.51e-01	0.031300	0.97000
APC truncation mutants have impaired AXIN binding	12	8.51e-01	0.031300	0.97000
AXIN missense mutants destabilize the destruction complex	12	8.51e-01	0.031300	0.97000
AXIN mutants destabilize the destruction complex, activating WNT signaling	12	8.51e-01	0.031300	0.97000
Truncations of AMER1 destabilize the destruction complex	12	8.51e-01	0.031300	0.97000
truncated APC mutants destabilize the destruction complex	12	8.51e-01	0.031300	0.97000
Mitochondrial translation termination	55	6.88e-01	-0.031300	0.94200
G alpha (s) signalling events	259	3.88e-01	0.031300	0.90700
FRS-mediated FGFR3 signaling	14	8.40e-01	0.031200	0.97000
Prostacyclin signalling through prostacyclin receptor	13	8.46e-01	-0.031200	0.97000
Cyclin A/B1/B2 associated events during G2/M transition	13	8.46e-01	-0.031000	0.97000
Digestion	16	8.30e-01	0.031000	0.97000
Uptake and actions of bacterial toxins	27	7.82e-01	-0.030800	0.95900
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	25	7.91e-01	-0.030700	0.95900
Cyclin E associated events during G1/S transition	56	6.92e-01	-0.030700	0.94200
G beta:gamma signalling through BTK	11	8.61e-01	0.030600	0.97200
Formation of Fibrin Clot (Clotting Cascade)	31	7.69e-01	0.030500	0.95700
Immune System	1476	5.55e-02	-0.030500	0.66300
Assembly and cell surface presentation of NMDA receptors	21	8.10e-01	-0.030400	0.96600
L1CAM interactions	84	6.32e-01	0.030300	0.93500
Regulation of PTEN gene transcription	48	7.19e-01	0.030100	0.95100
Cargo trafficking to the periciliary membrane	37	7.52e-01	-0.030000	0.95700
Influenza Viral RNA Transcription and Replication	61	6.86e-01	-0.029900	0.94200
Signaling by FGFR2	49	7.18e-01	-0.029900	0.95100
Vitamin B5 (pantothenate) metabolism	13	8.52e-01	0.029900	0.97000
Transcriptional activation of mitochondrial biogenesis	45	7.30e-01	-0.029800	0.95400
Olfactory Signaling Pathway	144	5.39e-01	0.029700	0.90700
Glyoxylate metabolism and glycine degradation	24	8.02e-01	0.029600	0.96200
Eukaryotic Translation Termination	35	7.62e-01	0.029600	0.95700
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	11	8.65e-01	-0.029500	0.97200
Degradation of beta-catenin by the destruction complex	60	6.95e-01	0.029300	0.94200
Signaling by NTRK1 (TRKA)	99	6.16e-01	0.029200	0.92900
Activation of SMO	10	8.73e-01	0.029200	0.97300
Signaling by GPCR	732	1.84e-01	0.029100	0.77600
G alpha (i) signalling events	290	3.96e-01	0.029100	0.90700
Toll Like Receptor 3 (TLR3) Cascade	75	6.64e-01	0.029000	0.94200
Peroxisomal protein import	48	7.29e-01	-0.029000	0.95400
Stimuli-sensing channels	78	6.59e-01	-0.029000	0.93800
Transcriptional regulation by RUNX3	75	6.65e-01	-0.028900	0.94200
Interleukin-4 and Interleukin-13 signaling	82	6.52e-01	-0.028900	0.93800
Signaling by Hedgehog	98	6.22e-01	0.028800	0.93100
Metabolism of lipids	555	2.50e-01	-0.028800	0.81300
mRNA decay by 3' to 5' exoribonuclease	10	8.75e-01	-0.028800	0.97300
ER to Golgi Anterograde Transport	104	6.14e-01	-0.028700	0.92900
Selenoamino acid metabolism	47	7.34e-01	0.028600	0.95400
Interleukin-1 family signaling	98	6.27e-01	-0.028400	0.93100
Cellular responses to stress	333	3.76e-01	-0.028300	0.90700
G alpha (q) signalling events	167	5.29e-01	0.028300	0.90700
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	45	7.44e-01	0.028200	0.95700
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	43	7.50e-01	0.028100	0.95700
Constitutive Signaling by NOTCH1 PEST Domain Mutants	43	7.50e-01	0.028100	0.95700
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	43	7.50e-01	0.028100	0.95700
Signaling by NOTCH1 PEST Domain Mutants in Cancer	43	7.50e-01	0.028100	0.95700
Signaling by NOTCH1 in Cancer	43	7.50e-01	0.028100	0.95700
Collagen chain trimerization	38	7.65e-01	0.028100	0.95700
Diseases associated with O-glycosylation of proteins	53	7.24e-01	-0.028100	0.95300
Striated Muscle Contraction	32	7.84e-01	0.028000	0.95900
Gap-filling DNA repair synthesis and ligation in TC-NER	42	7.55e-01	-0.027800	0.95700
Antimicrobial peptides	45	7.49e-01	0.027600	0.95700
COPI-mediated anterograde transport	66	6.99e-01	-0.027600	0.94200
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	8.80e-01	0.027600	0.97500
G1/S Transition	92	6.49e-01	-0.027500	0.93800
COPII-mediated vesicle transport	50	7.37e-01	0.027500	0.95500
Resolution of Abasic Sites (AP sites)	29	7.99e-01	0.027300	0.96200
Nuclear Events (kinase and transcription factor activation)	52	7.34e-01	0.027200	0.95400
Neddylation	166	5.52e-01	-0.026800	0.90700
Signaling by RAF1 mutants	30	8.00e-01	-0.026700	0.96200
Termination of O-glycan biosynthesis	17	8.49e-01	0.026700	0.97000
Assembly of collagen fibrils and other multimeric structures	44	7.60e-01	0.026700	0.95700
RNA Polymerase II Transcription	812	2.04e-01	-0.026500	0.78700
Phase I - Functionalization of compounds	83	6.77e-01	0.026500	0.94200
Diseases associated with glycosylation precursor biosynthesis	15	8.61e-01	0.026200	0.97200
Recycling of bile acids and salts	13	8.70e-01	-0.026100	0.97300
GLI3 is processed to GLI3R by the proteasome	38	7.81e-01	-0.026100	0.95900
Tight junction interactions	26	8.20e-01	0.025900	0.97000
Metabolism of vitamins and cofactors	135	6.06e-01	-0.025800	0.92500
MyD88-independent TLR4 cascade	78	6.97e-01	0.025600	0.94200
TRIF(TICAM1)-mediated TLR4 signaling	78	6.97e-01	0.025600	0.94200
Defective B3GALTL causes Peters-plus syndrome (PpS)	32	8.05e-01	0.025200	0.96300
HDMs demethylate histones	15	8.66e-01	0.025200	0.97200
Nephrin family interactions	19	8.51e-01	0.024900	0.97000
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	8.81e-01	0.024900	0.97500
FGFR3 ligand binding and activation	10	8.92e-01	-0.024700	0.97600
FGFR3c ligand binding and activation	10	8.92e-01	-0.024700	0.97600
RHO GTPases Activate NADPH Oxidases	20	8.50e-01	-0.024400	0.97000
AKT phosphorylates targets in the cytosol	12	8.84e-01	0.024300	0.97500
Gene Silencing by RNA	52	7.63e-01	0.024200	0.95700
G beta:gamma signalling through PI3Kgamma	17	8.63e-01	-0.024100	0.97200
Diseases of glycosylation	114	6.58e-01	-0.024100	0.93800
G alpha (12/13) signalling events	65	7.38e-01	0.024000	0.95500
Signaling by Rho GTPases	299	4.83e-01	-0.023700	0.90700
Fc epsilon receptor (FCERI) signaling	96	6.90e-01	0.023600	0.94200
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	23	8.46e-01	-0.023500	0.97000
Cytochrome P450 - arranged by substrate type	53	7.68e-01	-0.023400	0.95700
RHO GTPases Activate ROCKs	13	8.84e-01	-0.023400	0.97500
IGF1R signaling cascade	44	7.89e-01	0.023300	0.95900
O-glycosylation of TSR domain-containing proteins	33	8.17e-01	0.023300	0.97000
Nuclear Pore Complex (NPC) Disassembly	25	8.40e-01	0.023300	0.97000
MAPK family signaling cascades	235	5.41e-01	0.023200	0.90700
Glycosaminoglycan metabolism	93	6.99e-01	-0.023200	0.94200
GPCR ligand binding	337	4.70e-01	0.023000	0.90700
ADORA2B mediated anti-inflammatory cytokines production	108	6.81e-01	0.022900	0.94200
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	22	8.53e-01	-0.022900	0.97000
Regulation of Glucokinase by Glucokinase Regulatory Protein	22	8.53e-01	-0.022900	0.97000
Constitutive Signaling by Aberrant PI3K in Cancer	63	7.54e-01	0.022800	0.95700
Signaling by FGFR4	30	8.30e-01	0.022600	0.97000
Glycolysis	55	7.72e-01	-0.022600	0.95700
Pentose phosphate pathway	10	9.02e-01	0.022500	0.98000
Mitochondrial translation	61	7.62e-01	-0.022400	0.95700
Activation of NMDA receptors and postsynaptic events	62	7.62e-01	0.022200	0.95700
Metabolic disorders of biological oxidation enzymes	29	8.40e-01	-0.021700	0.97000
Phospholipid metabolism	163	6.34e-01	0.021700	0.93600
Metabolism of non-coding RNA	34	8.28e-01	0.021500	0.97000
snRNP Assembly	34	8.28e-01	0.021500	0.97000
Synthesis of PA	29	8.41e-01	0.021500	0.97000
G beta:gamma signalling through PLC beta	14	8.91e-01	-0.021100	0.97600
Transport of small molecules	557	4.04e-01	0.020800	0.90700
GPCR downstream signalling	688	3.58e-01	0.020700	0.90700
Lagging Strand Synthesis	16	8.86e-01	-0.020700	0.97600
Regulation of HSF1-mediated heat shock response	51	7.99e-01	-0.020600	0.96200
Disease	1074	2.69e-01	-0.020300	0.83200
Downstream signaling of activated FGFR3	19	8.79e-01	0.020200	0.97500
Intracellular signaling by second messengers	241	5.94e-01	0.020000	0.91500
Presynaptic depolarization and calcium channel opening	11	9.12e-01	-0.019300	0.98300
Gene expression (Transcription)	910	3.29e-01	-0.019300	0.89200
p130Cas linkage to MAPK signaling for integrins	13	9.05e-01	0.019200	0.98100
Defective B3GALT6 causes EDSP2 and SEMDJL1	14	9.01e-01	-0.019100	0.98000
PKMTs methylate histone lysines	32	8.53e-01	-0.019000	0.97000
Cytosolic sensors of pathogen-associated DNA	46	8.24e-01	-0.018900	0.97000
Platelet degranulation	99	7.48e-01	-0.018700	0.95700
Negative regulation of FGFR3 signaling	21	8.82e-01	-0.018700	0.97500
Synthesis, secretion, and deacylation of Ghrelin	13	9.07e-01	-0.018700	0.98100
Signaling by FGFR3	29	8.63e-01	-0.018500	0.97200
HDACs deacetylate histones	22	8.81e-01	0.018500	0.97500
Metalloprotease DUBs	16	8.98e-01	-0.018400	0.97900
Phase II - Conjugation of compounds	79	7.78e-01	-0.018400	0.95900
TRP channels	20	8.88e-01	0.018100	0.97600
Recognition of DNA damage by PCNA-containing replication complex	18	8.95e-01	0.018000	0.97700
RAF activation	27	8.75e-01	-0.017500	0.97300
Beta-catenin independent WNT signaling	111	7.52e-01	0.017400	0.95700
Triglyceride metabolism	28	8.74e-01	0.017300	0.97300
Respiratory electron transport	58	8.22e-01	-0.017100	0.97000
FCERI mediated NF-kB activation	54	8.30e-01	-0.016900	0.97000
Defective B3GAT3 causes JDSSDHD	15	9.10e-01	-0.016800	0.98200
Sphingolipid de novo biosynthesis	32	8.69e-01	-0.016800	0.97300
Retinoid metabolism and transport	30	8.75e-01	-0.016600	0.97300
Deubiquitination	184	7.02e-01	-0.016400	0.94200
BBSome-mediated cargo-targeting to cilium	18	9.04e-01	0.016400	0.98100
SARS-CoV-1 Infection	32	8.73e-01	0.016300	0.97300
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	32	8.75e-01	-0.016100	0.97300
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	13	9.20e-01	-0.016100	0.98500
ERK/MAPK targets	20	9.01e-01	0.016100	0.98000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	28	8.84e-01	0.016000	0.97500
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	9.27e-01	0.016000	0.98500
Signaling by FGFR	61	8.31e-01	-0.015800	0.97000
Keratan sulfate/keratin metabolism	25	8.92e-01	-0.015800	0.97600
Signaling by FGFR2 in disease	28	8.87e-01	-0.015500	0.97600
Leishmania infection	205	7.04e-01	-0.015400	0.94200
Fatty acid metabolism	132	7.60e-01	0.015400	0.95700
Post-translational protein modification	985	4.24e-01	-0.015300	0.90700
Unblocking of NMDA receptors, glutamate binding and activation	17	9.13e-01	0.015300	0.98400
HS-GAG degradation	16	9.17e-01	-0.015000	0.98500
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	27	8.94e-01	0.014800	0.97700
Activation of Ca-permeable Kainate Receptor	10	9.35e-01	0.014800	0.98500
Ionotropic activity of kainate receptors	10	9.35e-01	0.014800	0.98500
Signaling by TGF-beta Receptor Complex	50	8.57e-01	-0.014700	0.97200
Generic Transcription Pathway	727	5.04e-01	-0.014700	0.90700
HSF1-dependent transactivation	25	8.99e-01	-0.014700	0.97900
TP53 Regulates Metabolic Genes	62	8.49e-01	-0.014000	0.97000
RAB GEFs exchange GTP for GDP on RABs	64	8.48e-01	-0.013900	0.97000
Signaling by NOTCH1	56	8.59e-01	0.013800	0.97200
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	90	8.23e-01	0.013700	0.97000
SUMOylation of transcription factors	13	9.33e-01	0.013400	0.98500
Response to elevated platelet cytosolic Ca2+	103	8.15e-01	-0.013400	0.97000
Metabolism of fat-soluble vitamins	31	8.99e-01	0.013100	0.97900
Metabolism of amino acids and derivatives	245	7.26e-01	-0.013100	0.95300
Prefoldin mediated transfer of substrate to CCT/TriC	21	9.19e-01	-0.012900	0.98500
Disorders of transmembrane transporters	132	7.99e-01	-0.012900	0.96200
SHC-mediated cascade:FGFR1	17	9.30e-01	-0.012200	0.98500
Apoptotic cleavage of cellular proteins	31	9.07e-01	-0.012100	0.98100
Cellular response to heat stress	67	8.65e-01	0.012000	0.97200
Potassium Channels	78	8.56e-01	0.011900	0.97200
Metabolism of amine-derived hormones	15	9.37e-01	-0.011700	0.98600
Phospholipase C-mediated cascade; FGFR3	10	9.49e-01	0.011700	0.98600
Extracellular matrix organization	234	7.61e-01	-0.011600	0.95700
Platelet activation, signaling and aggregation	201	7.79e-01	-0.011500	0.95900
RNA Polymerase III Abortive And Retractive Initiation	27	9.19e-01	-0.011300	0.98500
RNA Polymerase III Transcription	27	9.19e-01	-0.011300	0.98500
Neurotransmitter release cycle	35	9.09e-01	0.011100	0.98200
Transcriptional regulation by RUNX1	136	8.23e-01	-0.011100	0.97000
Metabolism	1517	4.83e-01	-0.011000	0.90700
EPHB-mediated forward signaling	24	9.27e-01	-0.010900	0.98500
Dopamine Neurotransmitter Release Cycle	15	9.42e-01	0.010800	0.98600
Polymerase switching on the C-strand of the telomere	21	9.34e-01	0.010500	0.98500
Complex I biogenesis	35	9.15e-01	0.010500	0.98500
PI3K/AKT Signaling in Cancer	85	8.71e-01	0.010200	0.97300
Molecules associated with elastic fibres	28	9.26e-01	-0.010200	0.98500
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	9.56e-01	0.010000	0.98900
alpha-linolenic acid (ALA) metabolism	10	9.56e-01	0.010000	0.98900
PIP3 activates AKT signaling	207	8.04e-01	-0.010000	0.96300
Integrin signaling	23	9.34e-01	0.009980	0.98500
VxPx cargo-targeting to cilium	15	9.47e-01	-0.009910	0.98600
HSP90 chaperone cycle for steroid hormone receptors (SHR)	30	9.26e-01	-0.009770	0.98500
Phase 4 - resting membrane potential	16	9.46e-01	-0.009740	0.98600
p75 NTR receptor-mediated signalling	78	8.83e-01	0.009650	0.97500
Biosynthesis of specialized proresolving mediators (SPMs)	16	9.47e-01	0.009640	0.98600
Glucose metabolism	71	8.91e-01	-0.009450	0.97600
Base-Excision Repair, AP Site Formation	16	9.48e-01	0.009450	0.98600
Glutamate binding, activation of AMPA receptors and synaptic plasticity	26	9.34e-01	-0.009430	0.98500
Trafficking of AMPA receptors	26	9.34e-01	-0.009430	0.98500
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	64	8.99e-01	-0.009190	0.97900
SHC-mediated cascade:FGFR2	18	9.46e-01	-0.009150	0.98600
Toll-like Receptor Cascades	115	8.67e-01	0.009080	0.97200
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	87	8.88e-01	0.008750	0.97600
Biological oxidations	165	8.48e-01	0.008640	0.97000
NEP/NS2 Interacts with the Cellular Export Machinery	22	9.44e-01	-0.008600	0.98600
Diseases of metabolism	191	8.42e-01	-0.008410	0.97000
Anti-inflammatory response favouring Leishmania parasite infection	140	8.66e-01	-0.008290	0.97200
Leishmania parasite growth and survival	140	8.66e-01	-0.008290	0.97200
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	32	9.36e-01	0.008210	0.98500
Ion channel transport	131	8.71e-01	0.008200	0.97300
Cellular response to hypoxia	51	9.22e-01	-0.007940	0.98500
Ras activation upon Ca2+ influx through NMDA receptor	15	9.58e-01	-0.007910	0.99000
MAPK1/MAPK3 signaling	205	8.47e-01	0.007850	0.97000
Meiotic synapsis	28	9.43e-01	0.007820	0.98600
Lewis blood group biosynthesis	11	9.65e-01	-0.007580	0.99200
tRNA modification in the nucleus and cytosol	28	9.46e-01	0.007450	0.98600
Metabolism of water-soluble vitamins and cofactors	87	9.07e-01	-0.007260	0.98100
Regulation of expression of SLITs and ROBOs	87	9.10e-01	-0.007000	0.98200
Mitochondrial translation elongation	55	9.29e-01	-0.006960	0.98500
Degradation of GLI2 by the proteasome	39	9.40e-01	-0.006930	0.98600
Chondroitin sulfate biosynthesis	18	9.59e-01	0.006920	0.99000
Loss of Nlp from mitotic centrosomes	55	9.30e-01	-0.006860	0.98500
Loss of proteins required for interphase microtubule organization from the centrosome	55	9.30e-01	-0.006860	0.98500
Developmental Biology	707	7.61e-01	-0.006790	0.95700
XBP1(S) activates chaperone genes	38	9.42e-01	-0.006790	0.98600
Signal Transduction	1925	6.40e-01	0.006640	0.93600
Trafficking of GluR2-containing AMPA receptors	13	9.67e-01	0.006550	0.99200
Sema4D in semaphorin signaling	19	9.62e-01	-0.006330	0.99200
Diseases of signal transduction by growth factor receptors and second messengers	288	8.56e-01	-0.006260	0.97200
Apoptotic factor-mediated response	11	9.72e-01	0.006170	0.99200
Activation of kainate receptors upon glutamate binding	24	9.59e-01	-0.006140	0.99000
ABC transporters in lipid homeostasis	13	9.70e-01	0.006080	0.99200
Protein-protein interactions at synapses	72	9.32e-01	-0.005800	0.98500
RAS processing	12	9.73e-01	0.005660	0.99200
Asymmetric localization of PCP proteins	46	9.51e-01	-0.005240	0.98800
Keratinization	93	9.31e-01	0.005230	0.98500
FCERI mediated Ca+2 mobilization	24	9.65e-01	0.005200	0.99200
Axon guidance	385	8.63e-01	0.005160	0.97200
PI Metabolism	72	9.40e-01	0.005140	0.98600
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	42	9.55e-01	0.005080	0.98900
Transport to the Golgi and subsequent modification	127	9.22e-01	-0.005060	0.98500
Regulation of pyruvate dehydrogenase (PDH) complex	12	9.77e-01	-0.004720	0.99200
Cytokine Signaling in Immune system	615	8.43e-01	-0.004710	0.97000
Chromatin modifying enzymes	151	9.22e-01	-0.004600	0.98500
Chromatin organization	151	9.22e-01	-0.004600	0.98500
Negative regulation of the PI3K/AKT network	91	9.41e-01	0.004530	0.98600
MAPK targets/ Nuclear events mediated by MAP kinases	27	9.68e-01	0.004490	0.99200
RHO GTPases activate PKNs	27	9.68e-01	0.004400	0.99200
SUMOylation of RNA binding proteins	34	9.67e-01	0.004130	0.99200
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	11	9.81e-01	-0.004110	0.99200
Defective EXT2 causes exostoses 2	11	9.81e-01	-0.004110	0.99200
Signaling by NTRK3 (TRKC)	14	9.79e-01	-0.004020	0.99200
Degradation of the extracellular matrix	85	9.55e-01	0.003530	0.98900
Metabolism of carbohydrates	221	9.29e-01	0.003500	0.98500
MTOR signalling	31	9.74e-01	0.003380	0.99200
Signaling by PDGFRA extracellular domain mutants	10	9.85e-01	0.003350	0.99200
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	10	9.85e-01	0.003350	0.99200
Processive synthesis on the lagging strand	12	9.85e-01	0.003170	0.99200
Platelet calcium homeostasis	22	9.80e-01	-0.003160	0.99200
Intrinsic Pathway of Fibrin Clot Formation	18	9.82e-01	0.003150	0.99200
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	9.86e-01	0.003120	0.99200
Negative regulation of NMDA receptor-mediated neuronal transmission	16	9.83e-01	-0.003030	0.99200
Translation	154	9.49e-01	0.003020	0.98600
Post-chaperonin tubulin folding pathway	20	9.83e-01	-0.002730	0.99200
Biosynthesis of DHA-derived SPMs	14	9.86e-01	-0.002630	0.99200
Metabolism of steroid hormones	29	9.81e-01	0.002530	0.99200
Metabolism of proteins	1349	8.83e-01	-0.002440	0.97500
SHC-mediated cascade:FGFR4	15	9.88e-01	-0.002330	0.99200
Class A/1 (Rhodopsin-like receptors)	251	9.55e-01	-0.002060	0.98900
Mitochondrial translation initiation	55	9.80e-01	-0.001990	0.99200
Oncogene Induced Senescence	25	9.87e-01	-0.001850	0.99200
RAF/MAP kinase cascade	200	9.65e-01	-0.001810	0.99200
rRNA modification in the nucleus and cytosol	43	9.85e-01	0.001650	0.99200
Asparagine N-linked glycosylation	215	9.67e-01	0.001640	0.99200
FLT3 Signaling	213	9.73e-01	0.001370	0.99200
COPI-independent Golgi-to-ER retrograde traffic	27	9.90e-01	0.001340	0.99400
MAPK6/MAPK4 signaling	63	9.87e-01	0.001230	0.99200
Thrombin signalling through proteinase activated receptors (PARs)	24	9.92e-01	-0.001150	0.99500
SLC transporter disorders	80	9.87e-01	0.001090	0.99200
IRE1alpha activates chaperones	39	9.93e-01	-0.000859	0.99500
Nervous system development	407	9.83e-01	0.000623	0.99200
Long-term potentiation	19	9.97e-01	0.000464	0.99800
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	24	9.97e-01	-0.000407	0.99800
AURKA Activation by TPX2	57	9.99e-01	-0.000105	0.99900

---

Detailed Gene set reports

TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation

	1176
set	TRAF6 mediated IRF7 activation
setSize	27
pANOVA	1.46e-06
s.dist	-0.536
p.adjustANOVA	0.00124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF2	-6821
IFNA1	-6316
IFNA10	-6316
IFNA14	-6316
IFNA16	-6316
IFNA17	-6316
IFNA2	-6316
IFNA21	-6316
IFNA4	-6316
IFNA5	-6316
IFNA6	-6316
IFNA7	-6316
IFNA8	-6316
IFNB1	-5992
MAVS	-5703
IFIH1	-5154
SIKE1	-3637
TBK1	-3219
DDX58	-1641
CREBBP	-1444

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF2	-6821
IFNA1	-6316
IFNA10	-6316
IFNA14	-6316
IFNA16	-6316
IFNA17	-6316
IFNA2	-6316
IFNA21	-6316
IFNA4	-6316
IFNA5	-6316
IFNA6	-6316
IFNA7	-6316
IFNA8	-6316
IFNB1	-5992
MAVS	-5703
IFIH1	-5154
SIKE1	-3637
TBK1	-3219
DDX58	-1641
CREBBP	-1444
IKBKE	-1154
IRF3	-1023
TRAF6	-815
TANK	1184
RNF135	1347
EP300	3608
IRF7	5355

---

eNOS activation

eNOS activation

	1298
set	eNOS activation
setSize	10
pANOVA	0.00506
s.dist	-0.512
p.adjustANOVA	0.394

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPR	-6665
ZDHHC21	-4902
LYPLA1	-4789
DDAH1	-4461
HSP90AA1	-4350
DDAH2	-3833
NOS3	-3478
AKT1	-3281
CALM1	-1309
CAV1	1273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPR	-6665
ZDHHC21	-4902
LYPLA1	-4789
DDAH1	-4461
HSP90AA1	-4350
DDAH2	-3833
NOS3	-3478
AKT1	-3281
CALM1	-1309
CAV1	1273

---

Metabolism of nitric oxide: NOS3 activation and regulation

Metabolism of nitric oxide: NOS3 activation and regulation

	625
set	Metabolism of nitric oxide: NOS3 activation and regulation
setSize	14
pANOVA	0.00124
s.dist	-0.498
p.adjustANOVA	0.253

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPR	-6665
WASL	-6179
DNM2	-5280
ZDHHC21	-4902
LYPLA1	-4789
DDAH1	-4461
HSP90AA1	-4350
DDAH2	-3833
NOS3	-3478
AKT1	-3281
NOSIP	-2866
CALM1	-1309
CAV1	1273
NOSTRIN	1319

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPR	-6665
WASL	-6179
DNM2	-5280
ZDHHC21	-4902
LYPLA1	-4789
DDAH1	-4461
HSP90AA1	-4350
DDAH2	-3833
NOS3	-3478
AKT1	-3281
NOSIP	-2866
CALM1	-1309
CAV1	1273
NOSTRIN	1319

---

Retrograde neurotrophin signalling

Retrograde neurotrophin signalling

	987
set	Retrograde neurotrophin signalling
setSize	12
pANOVA	0.0042
s.dist	-0.477
p.adjustANOVA	0.394

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTA	-6547
DNAL4	-5870
AP2A2	-5862
DNM2	-5280
SH3GL2	-4563
CLTC	-4240
NGF	-3900
DNM1	-3730
AP2A1	-2450
AP2S1	-1235
AP2M1	-946
DNM3	4533

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTA	-6547
DNAL4	-5870
AP2A2	-5862
DNM2	-5280
SH3GL2	-4563
CLTC	-4240
NGF	-3900
DNM1	-3730
AP2A1	-2450
AP2S1	-1235
AP2M1	-946
DNM3	4533

---

TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling

	1162
set	TNFR1-induced proapoptotic signaling
setSize	12
pANOVA	0.0074
s.dist	-0.447
p.adjustANOVA	0.412

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF2	-6821
RIPK1	-5913
TNF	-5773
CASP8	-5315
USP21	-4281
OTUD7B	-4059
USP2	-3726
TNFRSF1A	-2204
CYLD	-1729
FADD	-1481
TRADD	-657
TNFAIP3	4396

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF2	-6821
RIPK1	-5913
TNF	-5773
CASP8	-5315
USP21	-4281
OTUD7B	-4059
USP2	-3726
TNFRSF1A	-2204
CYLD	-1729
FADD	-1481
TRADD	-657
TNFAIP3	4396

---

Interleukin-35 Signalling

Interleukin-35 Signalling

	553
set	Interleukin-35 Signalling
setSize	11
pANOVA	0.0113
s.dist	0.441
p.adjustANOVA	0.415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL27RA	6795
IL12RB2	6704
TYK2	4209
STAT4	3927
EBI3	3797
IL6ST	2878
CANX	2655
STAT1	2060
STAT3	1761
IL12A	1073
JAK1	-3277

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL27RA	6795
IL12RB2	6704
TYK2	4209
STAT4	3927
EBI3	3797
IL6ST	2878
CANX	2655
STAT1	2060
STAT3	1761
IL12A	1073
JAK1	-3277

---

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

	978
set	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
setSize	19
pANOVA	0.000956
s.dist	-0.438
p.adjustANOVA	0.253

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EXO1	-6266.0
BARD1	-5821.0
RAD51AP1	-5774.0
RAD51D	-5624.0
XRCC3	-5419.0
RMI1	-5059.0
ATM	-5018.0
BRCA1	-4931.0
RTEL1	-4521.5
TOP3A	-4233.0
RAD50	-4063.0
DNA2	-2097.0
RBBP8	-1866.0
KAT5	-1601.0
XRCC2	-1097.0
PALB2	-992.0
RAD51	1300.0
RMI2	1360.0
RAD51B	3423.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EXO1	-6266.0
BARD1	-5821.0
RAD51AP1	-5774.0
RAD51D	-5624.0
XRCC3	-5419.0
RMI1	-5059.0
ATM	-5018.0
BRCA1	-4931.0
RTEL1	-4521.5
TOP3A	-4233.0
RAD50	-4063.0
DNA2	-2097.0
RBBP8	-1866.0
KAT5	-1601.0
XRCC2	-1097.0
PALB2	-992.0
RAD51	1300.0
RMI2	1360.0
RAD51B	3423.0

---

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

	674
set	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize	10
pANOVA	0.0237
s.dist	-0.413
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RIPK1	-5913
MAVS	-5703
CASP8	-5315
IFIH1	-5154
CHUK	-5021
DDX58	-1641
FADD	-1481
IKBKB	-1079
IKBKG	947
RNF135	1347

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RIPK1	-5913
MAVS	-5703
CASP8	-5315
IFIH1	-5154
CHUK	-5021
DDX58	-1641
FADD	-1481
IKBKB	-1079
IKBKG	947
RNF135	1347

---

SHC1 events in EGFR signaling

SHC1 events in EGFR signaling

	1008
set	SHC1 events in EGFR signaling
setSize	10
pANOVA	0.0278
s.dist	-0.402
p.adjustANOVA	0.454

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EGF	-6839.0
HRAS	-6148.0
SHC1	-5795.0
HBEGF	-5787.0
EPGN	-5155.0
EGFR	-3646.0
TGFA	-592.0
AREG	926.5
GRB2	964.0
KRAS	3840.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EGF	-6839.0
HRAS	-6148.0
SHC1	-5795.0
HBEGF	-5787.0
EPGN	-5155.0
EGFR	-3646.0
TGFA	-592.0
AREG	926.5
GRB2	964.0
KRAS	3840.0

---

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

	324
set	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
setSize	13
pANOVA	0.0128
s.dist	-0.399
p.adjustANOVA	0.415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TTF1	-6657
CHD4	-6434
GATAD2A	-5920
H2AFX	-5360
HDAC2	-5067
RBBP7	-4764
MTA2	-3387
MTA1	-2598
CHD3	-1362
MBD3	-948
EHMT2	1116
MTA3	2290
ERCC6	2657

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TTF1	-6657
CHD4	-6434
GATAD2A	-5920
H2AFX	-5360
HDAC2	-5067
RBBP7	-4764
MTA2	-3387
MTA1	-2598
CHD3	-1362
MBD3	-948
EHMT2	1116
MTA3	2290
ERCC6	2657

---

Regulation of TP53 Activity through Association with Co-factors

Regulation of TP53 Activity through Association with Co-factors

	946
set	Regulation of TP53 Activity through Association with Co-factors
setSize	11
pANOVA	0.0224
s.dist	-0.398
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP1R13L	-6291
AKT2	-5341
PHF20	-5185
PPP1R13B	-3924
ZNF385A	-3822
POU4F2	-3729
TP73	-3608
AKT1	-3281
BANP	-2060
TP53	171
TP63	6330

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP1R13L	-6291
AKT2	-5341
PHF20	-5185
PPP1R13B	-3924
ZNF385A	-3822
POU4F2	-3729
TP73	-3608
AKT1	-3281
BANP	-2060
TP53	171
TP63	6330

---

Regulation of FZD by ubiquitination

Regulation of FZD by ubiquitination

	926
set	Regulation of FZD by ubiquitination
setSize	13
pANOVA	0.0145
s.dist	0.392
p.adjustANOVA	0.415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FZD8	5887.0
LRP5	5727.5
RNF43	5567.0
FZD5	5421.0
ZNRF3	5180.0
RSPO1	4671.0
FZD4	2248.0
UBA52	1318.0
LGR5	922.0
LRP6	487.0
RSPO4	367.0
LGR4	-1807.0
LGR6	-1905.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FZD8	5887.0
LRP5	5727.5
RNF43	5567.0
FZD5	5421.0
ZNRF3	5180.0
RSPO1	4671.0
FZD4	2248.0
UBA52	1318.0
LGR5	922.0
LRP6	487.0
RSPO4	367.0
LGR4	-1807.0
LGR6	-1905.0

---

Regulation of IFNA signaling

Regulation of IFNA signaling

	929
set	Regulation of IFNA signaling
setSize	23
pANOVA	0.00134
s.dist	-0.387
p.adjustANOVA	0.253

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFNA1	-6316.0
IFNA10	-6316.0
IFNA14	-6316.0
IFNA16	-6316.0
IFNA17	-6316.0
IFNA2	-6316.0
IFNA21	-6316.0
IFNA4	-6316.0
IFNA5	-6316.0
IFNA6	-6316.0
IFNA7	-6316.0
IFNA8	-6316.0
IFNB1	-5992.0
PTPN6	-3640.0
JAK1	-3277.0
USP18	-3247.5
PTPN11	828.0
STAT1	2060.0
TYK2	4209.0
PTPN1	4599.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFNA1	-6316.0
IFNA10	-6316.0
IFNA14	-6316.0
IFNA16	-6316.0
IFNA17	-6316.0
IFNA2	-6316.0
IFNA21	-6316.0
IFNA4	-6316.0
IFNA5	-6316.0
IFNA6	-6316.0
IFNA7	-6316.0
IFNA8	-6316.0
IFNB1	-5992.0
PTPN6	-3640.0
JAK1	-3277.0
USP18	-3247.5
PTPN11	828.0
STAT1	2060.0
TYK2	4209.0
PTPN1	4599.0
SOCS3	5597.0
IFNAR1	5995.0
IFNAR2	6192.0

---

TP53 Regulates Transcription of Death Receptors and Ligands

TP53 Regulates Transcription of Death Receptors and Ligands

	1169
set	TP53 Regulates Transcription of Death Receptors and Ligands
setSize	10
pANOVA	0.0344
s.dist	-0.386
p.adjustANOVA	0.499

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF10A	-6801.5
TNFRSF10B	-6801.5
TNFRSF10C	-6801.5
TNFRSF10D	-6801.5
TMEM219	-5636.0
PPP1R13B	-3924.0
TP73	-3608.0
TP53	171.0
TP63	6330.0
IGFBP3	6702.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF10A	-6801.5
TNFRSF10B	-6801.5
TNFRSF10C	-6801.5
TNFRSF10D	-6801.5
TMEM219	-5636.0
PPP1R13B	-3924.0
TP73	-3608.0
TP53	171.0
TP63	6330.0
IGFBP3	6702.0

---

Signal regulatory protein family interactions

Signal regulatory protein family interactions

	1043
set	Signal regulatory protein family interactions
setSize	11
pANOVA	0.0274
s.dist	-0.384
p.adjustANOVA	0.454

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIRPA	-6919.5
SIRPB1	-6919.5
SIRPG	-6919.5
CD47	-6346.0
TYROBP	-4680.0
PTPN6	-3640.0
SRC	48.0
FYB	402.0
PTPN11	828.0
GRB2	964.0
PTK2B	3455.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIRPA	-6919.5
SIRPB1	-6919.5
SIRPG	-6919.5
CD47	-6346.0
TYROBP	-4680.0
PTPN6	-3640.0
SRC	48.0
FYB	402.0
PTPN11	828.0
GRB2	964.0
PTK2B	3455.0

---

Classical antibody-mediated complement activation

Classical antibody-mediated complement activation

	189
set	Classical antibody-mediated complement activation
setSize	10
pANOVA	0.0391
s.dist	-0.377
p.adjustANOVA	0.539

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGHG1	-6930.5
IGHG2	-6930.5
IGHG3	-6930.5
IGHG4	-6930.5
C1S	-6636.0
C1QA	-3276.0
CRP	2202.0
C1QC	2272.0
C1QB	2508.0
C1R	4127.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGHG1	-6930.5
IGHG2	-6930.5
IGHG3	-6930.5
IGHG4	-6930.5
C1S	-6636.0
C1QA	-3276.0
CRP	2202.0
C1QC	2272.0
C1QB	2508.0
C1R	4127.0

---

ER Quality Control Compartment (ERQC)

ER Quality Control Compartment (ERQC)

	319
set	ER Quality Control Compartment (ERQC)
setSize	12
pANOVA	0.0243
s.dist	-0.375
p.adjustANOVA	0.442

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EDEM3	-6465
RNF139	-6357
TRIM13	-5801
OS9	-5294
UGGT1	-5094
EDEM2	-4168
UGGT2	-3813
SEL1L	-2666
AMFR	-1711
UBA52	1318
MAN1B1	3442
SYVN1	4903

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EDEM3	-6465
RNF139	-6357
TRIM13	-5801
OS9	-5294
UGGT1	-5094
EDEM2	-4168
UGGT2	-3813
SEL1L	-2666
AMFR	-1711
UBA52	1318
MAN1B1	3442
SYVN1	4903

---

Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere

	267
set	Deposition of new CENPA-containing nucleosomes at the centromere
setSize	16
pANOVA	0.00965
s.dist	-0.374
p.adjustANOVA	0.412

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CENPQ	-6810
SMARCA5	-6601
CENPI	-6415
CENPT	-5577
H2AFX	-5360
CENPM	-5027
RBBP7	-4764
CENPC	-4636
RSF1	-4304
MIS18BP1	-2997
CENPN	-2550
CENPA	-2513
CENPH	-1329
RUVBL1	5299
HJURP	5678
CENPO	5827

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CENPQ	-6810
SMARCA5	-6601
CENPI	-6415
CENPT	-5577
H2AFX	-5360
CENPM	-5027
RBBP7	-4764
CENPC	-4636
RSF1	-4304
MIS18BP1	-2997
CENPN	-2550
CENPA	-2513
CENPH	-1329
RUVBL1	5299
HJURP	5678
CENPO	5827

---

Nucleosome assembly

Nucleosome assembly

	732
set	Nucleosome assembly
setSize	16
pANOVA	0.00965
s.dist	-0.374
p.adjustANOVA	0.412

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CENPQ	-6810
SMARCA5	-6601
CENPI	-6415
CENPT	-5577
H2AFX	-5360
CENPM	-5027
RBBP7	-4764
CENPC	-4636
RSF1	-4304
MIS18BP1	-2997
CENPN	-2550
CENPA	-2513
CENPH	-1329
RUVBL1	5299
HJURP	5678
CENPO	5827

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CENPQ	-6810
SMARCA5	-6601
CENPI	-6415
CENPT	-5577
H2AFX	-5360
CENPM	-5027
RBBP7	-4764
CENPC	-4636
RSF1	-4304
MIS18BP1	-2997
CENPN	-2550
CENPA	-2513
CENPH	-1329
RUVBL1	5299
HJURP	5678
CENPO	5827

---

Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand

	942
set	Regulation of TLR by endogenous ligand
setSize	13
pANOVA	0.0225
s.dist	-0.366
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD36	-6495
S100A8	-6305
TLR1	-5799
FGG	-5765
LY96	-4092
CD14	-3986
HMGB1	-3151
FGA	-2244
LBP	-1150
APOB	1054
TLR6	1283
TLR2	1550
FGB	1626

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD36	-6495
S100A8	-6305
TLR1	-5799
FGG	-5765
LY96	-4092
CD14	-3986
HMGB1	-3151
FGA	-2244
LBP	-1150
APOB	1054
TLR6	1283
TLR2	1550
FGB	1626

---

DDX58/IFIH1-mediated induction of interferon-alpha/beta

DDX58/IFIH1-mediated induction of interferon-alpha/beta

	228
set	DDX58/IFIH1-mediated induction of interferon-alpha/beta
setSize	58
pANOVA	1.88e-06
s.dist	-0.362
p.adjustANOVA	0.00124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF2	-6821
RNF125	-6572
IFNA1	-6316
IFNA10	-6316
IFNA14	-6316
IFNA16	-6316
IFNA17	-6316
IFNA2	-6316
IFNA21	-6316
IFNA4	-6316
IFNA5	-6316
IFNA6	-6316
IFNA7	-6316
IFNA8	-6316
NFKB2	-5993
IFNB1	-5992
RIPK1	-5913
MAVS	-5703
TAX1BP1	-5375
CASP8	-5315

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF2	-6821
RNF125	-6572
IFNA1	-6316
IFNA10	-6316
IFNA14	-6316
IFNA16	-6316
IFNA17	-6316
IFNA2	-6316
IFNA21	-6316
IFNA4	-6316
IFNA5	-6316
IFNA6	-6316
IFNA7	-6316
IFNA8	-6316
NFKB2	-5993
IFNB1	-5992
RIPK1	-5913
MAVS	-5703
TAX1BP1	-5375
CASP8	-5315
IFIH1	-5154
CHUK	-5021
NLRC5	-4071
NFKB1	-3934
RNF216	-3764
NFKBIA	-3749
SIKE1	-3637
S100B	-3595
TBK1	-3219
HMGB1	-3151
NLRX1	-1885
CYLD	-1729
DDX58	-1641
FADD	-1481
CREBBP	-1444
RELA	-1241
IKBKE	-1154
IKBKB	-1079
IRF3	-1023
TRAF6	-815
DHX58	-722
ATG5	-249
UBE2L6	-10
TRAF3	285
UBE2D1	572
NKIRAS2	748
IKBKG	947
TANK	1184
UBA52	1318
RNF135	1347
MAP3K1	1394
NFKBIB	1990
APP	2036
UBA7	2322
UBE2K	2346
EP300	3608
TNFAIP3	4396
IRF7	5355

---

Passive transport by Aquaporins

Passive transport by Aquaporins

	781
set	Passive transport by Aquaporins
setSize	12
pANOVA	0.0305
s.dist	0.361
p.adjustANOVA	0.474

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AQP1	6700.0
AQP9	5614.0
AQP11	4968.0
AQP6	4541.0
AQP8	4095.0
AQP12A	3837.5
AQP7	3574.0
AQP2	2884.0
AQP3	-1119.0
AQP4	-1839.0
MIP	-1903.0
AQP5	-2433.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AQP1	6700.0
AQP9	5614.0
AQP11	4968.0
AQP6	4541.0
AQP8	4095.0
AQP12A	3837.5
AQP7	3574.0
AQP2	2884.0
AQP3	-1119.0
AQP4	-1839.0
MIP	-1903.0
AQP5	-2433.0

---

Resolution of D-Loop Structures

Resolution of D-Loop Structures

	976
set	Resolution of D-Loop Structures
setSize	23
pANOVA	0.00286
s.dist	-0.359
p.adjustANOVA	0.394

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EXO1	-6266.0
BARD1	-5821.0
RAD51AP1	-5774.0
RAD51D	-5624.0
XRCC3	-5419.0
RMI1	-5059.0
ATM	-5018.0
BRCA1	-4931.0
RTEL1	-4521.5
TOP3A	-4233.0
RAD50	-4063.0
EME2	-3449.0
MUS81	-2534.0
DNA2	-2097.0
RBBP8	-1866.0
KAT5	-1601.0
XRCC2	-1097.0
PALB2	-992.0
EME1	1205.0
RAD51	1300.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EXO1	-6266.0
BARD1	-5821.0
RAD51AP1	-5774.0
RAD51D	-5624.0
XRCC3	-5419.0
RMI1	-5059.0
ATM	-5018.0
BRCA1	-4931.0
RTEL1	-4521.5
TOP3A	-4233.0
RAD50	-4063.0
EME2	-3449.0
MUS81	-2534.0
DNA2	-2097.0
RBBP8	-1866.0
KAT5	-1601.0
XRCC2	-1097.0
PALB2	-992.0
EME1	1205.0
RAD51	1300.0
RMI2	1360.0
RAD51B	3423.0
SLX4	4898.0

---

RNA Pol II CTD phosphorylation and interaction with CE

RNA Pol II CTD phosphorylation and interaction with CE

	875
set	RNA Pol II CTD phosphorylation and interaction with CE
setSize	15
pANOVA	0.0189
s.dist	-0.35
p.adjustANOVA	0.42

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780.0
CCNH	-6761.0
RNGTT	-5987.0
GTF2F1	-5976.0
SUPT5H	-5867.0
RNMT	-5585.0
POLR2E	-4663.0
GTF2H2	-3577.5
POLR2B	-2163.0
GTF2H3	-1447.0
ERCC2	-455.0
POLR2C	421.0
GTF2H1	458.0
GTF2H4	5330.0
ERCC3	6024.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780.0
CCNH	-6761.0
RNGTT	-5987.0
GTF2F1	-5976.0
SUPT5H	-5867.0
RNMT	-5585.0
POLR2E	-4663.0
GTF2H2	-3577.5
POLR2B	-2163.0
GTF2H3	-1447.0
ERCC2	-455.0
POLR2C	421.0
GTF2H1	458.0
GTF2H4	5330.0
ERCC3	6024.0

---

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

	876
set	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
setSize	15
pANOVA	0.0189
s.dist	-0.35
p.adjustANOVA	0.42

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780.0
CCNH	-6761.0
RNGTT	-5987.0
GTF2F1	-5976.0
SUPT5H	-5867.0
RNMT	-5585.0
POLR2E	-4663.0
GTF2H2	-3577.5
POLR2B	-2163.0
GTF2H3	-1447.0
ERCC2	-455.0
POLR2C	421.0
GTF2H1	458.0
GTF2H4	5330.0
ERCC3	6024.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780.0
CCNH	-6761.0
RNGTT	-5987.0
GTF2F1	-5976.0
SUPT5H	-5867.0
RNMT	-5585.0
POLR2E	-4663.0
GTF2H2	-3577.5
POLR2B	-2163.0
GTF2H3	-1447.0
ERCC2	-455.0
POLR2C	421.0
GTF2H1	458.0
GTF2H4	5330.0
ERCC3	6024.0

---

Resolution of D-loop Structures through Holliday Junction Intermediates

Resolution of D-loop Structures through Holliday Junction Intermediates

	977
set	Resolution of D-loop Structures through Holliday Junction Intermediates
setSize	22
pANOVA	0.00496
s.dist	-0.346
p.adjustANOVA	0.394

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EXO1	-6266
BARD1	-5821
RAD51AP1	-5774
RAD51D	-5624
XRCC3	-5419
RMI1	-5059
ATM	-5018
BRCA1	-4931
TOP3A	-4233
RAD50	-4063
EME2	-3449
MUS81	-2534
DNA2	-2097
RBBP8	-1866
KAT5	-1601
XRCC2	-1097
PALB2	-992
EME1	1205
RAD51	1300
RMI2	1360

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EXO1	-6266
BARD1	-5821
RAD51AP1	-5774
RAD51D	-5624
XRCC3	-5419
RMI1	-5059
ATM	-5018
BRCA1	-4931
TOP3A	-4233
RAD50	-4063
EME2	-3449
MUS81	-2534
DNA2	-2097
RBBP8	-1866
KAT5	-1601
XRCC2	-1097
PALB2	-992
EME1	1205
RAD51	1300
RMI2	1360
RAD51B	3423
SLX4	4898

---

HIV elongation arrest and recovery

HIV elongation arrest and recovery

	481
set	HIV elongation arrest and recovery
setSize	15
pANOVA	0.0233
s.dist	-0.338
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

---

Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation

	782
set	Pausing and recovery of HIV elongation
setSize	15
pANOVA	0.0233
s.dist	-0.338
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

---

Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation

	783
set	Pausing and recovery of Tat-mediated HIV elongation
setSize	15
pANOVA	0.0233
s.dist	-0.338
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

---

Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery

	1183
set	Tat-mediated HIV elongation arrest and recovery
setSize	15
pANOVA	0.0233
s.dist	-0.338
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780
CDK9	-6087
GTF2F1	-5976
SUPT5H	-5867
CTDP1	-5012
ELL	-4834
POLR2E	-4663
SSRP1	-4391
CCNT1	-3169
POLR2B	-2163
NELFCD	337
POLR2C	421
NELFE	1475
SUPT4H1	4419
NELFB	6473

---

VLDLR internalisation and degradation

VLDLR internalisation and degradation

	1274
set	VLDLR internalisation and degradation
setSize	11
pANOVA	0.0522
s.dist	-0.338
p.adjustANOVA	0.663

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTA	-6547
AP2A2	-5862
NR1H2	-5336
NR1H3	-4839
CLTC	-4240
AP2A1	-2450
PCSK9	-1963
AP2S1	-1235
AP2M1	-946
MYLIP	837
VLDLR	6331

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTA	-6547
AP2A2	-5862
NR1H2	-5336
NR1H3	-4839
CLTC	-4240
AP2A1	-2450
PCSK9	-1963
AP2S1	-1235
AP2M1	-946
MYLIP	837
VLDLR	6331

---

mRNA Capping

mRNA Capping

	1300
set	mRNA Capping
setSize	16
pANOVA	0.0208
s.dist	-0.334
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-6780.0
CCNH	-6761.0
RNGTT	-5987.0
GTF2F1	-5976.0
SUPT5H	-5867.0
RNMT	-5585.0
POLR2E	-4663.0
GTF2H2	-3577.5
POLR2B	-2163.0
GTF2H3	-1447.0
NCBP1	-681.0
ERCC2	-455.0
POLR2C	421.0
GTF2H1	458.0
GTF2H4	5330.0
ERCC3	6024.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-6780.0
CCNH	-6761.0
RNGTT	-5987.0
GTF2F1	-5976.0
SUPT5H	-5867.0
RNMT	-5585.0
POLR2E	-4663.0
GTF2H2	-3577.5
POLR2B	-2163.0
GTF2H3	-1447.0
NCBP1	-681.0
ERCC2	-455.0
POLR2C	421.0
GTF2H1	458.0
GTF2H4	5330.0
ERCC3	6024.0

---

Other interleukin signaling

Other interleukin signaling

	748
set	Other interleukin signaling
setSize	17
pANOVA	0.0177
s.dist	0.332
p.adjustANOVA	0.42

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VAMP2	6323.0
PTPRZ1	5769.0
IL10RB	5639.5
CSF3R	5095.0
TXLNA	4655.0
CD4	4614.0
IL34	4431.0
TYK2	4209.0
CSF1R	3988.0
CSF1	2579.0
PRTN3	2532.0
STX4	124.0
STX1A	2.0
IL16	-2674.0
CSF3	-2819.0
JAK1	-3277.0
STXBP2	-3553.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VAMP2	6323.0
PTPRZ1	5769.0
IL10RB	5639.5
CSF3R	5095.0
TXLNA	4655.0
CD4	4614.0
IL34	4431.0
TYK2	4209.0
CSF1R	3988.0
CSF1	2579.0
PRTN3	2532.0
STX4	124.0
STX1A	2.0
IL16	-2674.0
CSF3	-2819.0
JAK1	-3277.0
STXBP2	-3553.0

---

CD28 dependent PI3K/Akt signaling

CD28 dependent PI3K/Akt signaling

	124
set	CD28 dependent PI3K/Akt signaling
setSize	19
pANOVA	0.0164
s.dist	-0.318
p.adjustANOVA	0.415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPKAP1	-6536
MLST8	-6474
MAP3K8	-5988
CD86	-5707
AKT2	-5341
THEM4	-4409
MTOR	-4120
AKT1	-3281
LCK	-3265
PIK3CA	-2828
PDPK1	-2330
CD28	-1873
RICTOR	-1008
PIK3R3	-285
PIK3R2	152
PRR5	952
PIK3R1	1605
CD80	2427
FYN	5611

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPKAP1	-6536
MLST8	-6474
MAP3K8	-5988
CD86	-5707
AKT2	-5341
THEM4	-4409
MTOR	-4120
AKT1	-3281
LCK	-3265
PIK3CA	-2828
PDPK1	-2330
CD28	-1873
RICTOR	-1008
PIK3R3	-285
PIK3R2	152
PRR5	952
PIK3R1	1605
CD80	2427
FYN	5611

---

Glutathione synthesis and recycling

Glutathione synthesis and recycling

	454
set	Glutathione synthesis and recycling
setSize	11
pANOVA	0.07
s.dist	-0.316
p.adjustANOVA	0.68

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GGCT	-6569
CNDP2	-5342
CHAC1	-5302
GSS	-5286
GGT5	-3953
GGT1	-3445
GGT7	-1858
GCLM	-479
OPLAH	-139
GGT6	2084
GCLC	5744

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GGCT	-6569
CNDP2	-5342
CHAC1	-5302
GSS	-5286
GGT5	-3953
GGT1	-3445
GGT7	-1858
GCLM	-479
OPLAH	-139
GGT6	2084
GCLC	5744

---

VEGFR2 mediated vascular permeability

VEGFR2 mediated vascular permeability

	1273
set	VEGFR2 mediated vascular permeability
setSize	24
pANOVA	0.00762
s.dist	-0.315
p.adjustANOVA	0.412

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPKAP1	-6536
PAK3	-6480
MLST8	-6474
VAV3	-6433
AKT2	-5341
CDH5	-4709
THEM4	-4409
HSP90AA1	-4350
JUP	-4165
MTOR	-4120
CTNND1	-3558
NOS3	-3478
AKT1	-3281
VAV1	-2579
PDPK1	-2330
CALM1	-1309
RICTOR	-1008
CTNNB1	332
CTNNA1	893
PRR5	952

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPKAP1	-6536
PAK3	-6480
MLST8	-6474
VAV3	-6433
AKT2	-5341
CDH5	-4709
THEM4	-4409
HSP90AA1	-4350
JUP	-4165
MTOR	-4120
CTNND1	-3558
NOS3	-3478
AKT1	-3281
VAV1	-2579
PDPK1	-2330
CALM1	-1309
RICTOR	-1008
CTNNB1	332
CTNNA1	893
PRR5	952
CAV1	1273
VAV2	2821
PAK2	5366
RAC1	5552

---

Budding and maturation of HIV virion

Budding and maturation of HIV virion

	118
set	Budding and maturation of HIV virion
setSize	17
pANOVA	0.0261
s.dist	-0.312
p.adjustANOVA	0.454

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDCD6IP	-6581.0
NEDD4L	-5953.0
VPS4B	-5224.0
PPIA	-4803.0
TSG101	-4668.0
CHMP4C	-4458.0
MVB12A	-3935.0
CHMP3	-2386.5
MVB12B	-2078.0
CHMP4B	-1921.0
VPS37D	-1798.0
CHMP6	-1511.0
VPS4A	-723.5
CHMP7	461.0
UBA52	1318.0
UBAP1	1372.0
VPS37B	5411.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDCD6IP	-6581.0
NEDD4L	-5953.0
VPS4B	-5224.0
PPIA	-4803.0
TSG101	-4668.0
CHMP4C	-4458.0
MVB12A	-3935.0
CHMP3	-2386.5
MVB12B	-2078.0
CHMP4B	-1921.0
VPS37D	-1798.0
CHMP6	-1511.0
VPS4A	-723.5
CHMP7	461.0
UBA52	1318.0
UBAP1	1372.0
VPS37B	5411.0

---

PKA activation

PKA activation

	770
set	PKA activation
setSize	16
pANOVA	0.0317
s.dist	0.31
p.adjustANOVA	0.477

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY9	6439
ADCY6	5074
PRKAR2B	5033
NBEA	4990
ADCY1	4363
PRKAR1A	4133
PRKACB	4056
PRKACA	3726
ADCY5	2725
ADCY7	2715
ADCY2	234
ADCY8	-772
CALM1	-1309
ADCY3	-1585
ADCY4	-3004
PRKAR1B	-3817

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY9	6439
ADCY6	5074
PRKAR2B	5033
NBEA	4990
ADCY1	4363
PRKAR1A	4133
PRKACB	4056
PRKACA	3726
ADCY5	2725
ADCY7	2715
ADCY2	234
ADCY8	-772
CALM1	-1309
ADCY3	-1585
ADCY4	-3004
PRKAR1B	-3817

---

Downregulation of ERBB2 signaling

Downregulation of ERBB2 signaling

	297
set	Downregulation of ERBB2 signaling
setSize	18
pANOVA	0.0233
s.dist	-0.309
p.adjustANOVA	0.436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EGF	-6839
PTPN18	-6498
HBEGF	-5787
AKT2	-5341
CUL5	-5243
PTPN12	-4605
HSP90AA1	-4350
NRG2	-3665
EGFR	-3646
MATK	-3291
AKT1	-3281
NRG4	-2290
NRG1	-2048
UBA52	1318
ERBB3	1914
NRG3	1984
ERBB2	5655
CDC37	6679

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EGF	-6839
PTPN18	-6498
HBEGF	-5787
AKT2	-5341
CUL5	-5243
PTPN12	-4605
HSP90AA1	-4350
NRG2	-3665
EGFR	-3646
MATK	-3291
AKT1	-3281
NRG4	-2290
NRG1	-2048
UBA52	1318
ERBB3	1914
NRG3	1984
ERBB2	5655
CDC37	6679

---

NOTCH3 Activation and Transmission of Signal to the Nucleus

NOTCH3 Activation and Transmission of Signal to the Nucleus

	681
set	NOTCH3 Activation and Transmission of Signal to the Nucleus
setSize	17
pANOVA	0.0275
s.dist	-0.309
p.adjustANOVA	0.454

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TACC3	-6882
WWP2	-6880
EGF	-6839
YBX1	-4326
JAG2	-4275
JAG1	-4250
DLL4	-3733
EGFR	-3646
NOTCH3	-3054
MIB2	-2539
PSEN1	-2336
NCSTN	-561
DLL1	141
UBA52	1318
PSEN2	2039
ADAM10	2504
APH1A	6191

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TACC3	-6882
WWP2	-6880
EGF	-6839
YBX1	-4326
JAG2	-4275
JAG1	-4250
DLL4	-3733
EGFR	-3646
NOTCH3	-3054
MIB2	-2539
PSEN1	-2336
NCSTN	-561
DLL1	141
UBA52	1318
PSEN2	2039
ADAM10	2504
APH1A	6191

---

Class I peroxisomal membrane protein import

Class I peroxisomal membrane protein import

	188
set	Class I peroxisomal membrane protein import
setSize	11
pANOVA	0.0794
s.dist	-0.306
p.adjustANOVA	0.683

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PEX14	-6692
PXMP4	-6509
ABCD2	-5307
PEX11B	-4687
GDAP1	-4608
ABCD3	-2427
PEX3	-2312
PEX19	-1689
ALDH3A2	-1672
FIS1	5834
PEX26	6281

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PEX14	-6692
PXMP4	-6509
ABCD2	-5307
PEX11B	-4687
GDAP1	-4608
ABCD3	-2427
PEX3	-2312
PEX19	-1689
ALDH3A2	-1672
FIS1	5834
PEX26	6281

---

Translesion Synthesis by POLH

Translesion Synthesis by POLH

	1235
set	Translesion Synthesis by POLH
setSize	11
pANOVA	0.0795
s.dist	0.305
p.adjustANOVA	0.683

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UFD1L	6635
RFC3	5617
PCNA	5346
RPA1	4065
RCHY1	3581
RPA2	2300
NPLOC4	1890
RFC1	1460
UBA52	1318
RFC4	-3811
RFC5	-6064

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UFD1L	6635
RFC3	5617
PCNA	5346
RPA1	4065
RCHY1	3581
RPA2	2300
NPLOC4	1890
RFC1	1460
UBA52	1318
RFC4	-3811
RFC5	-6064

---

Signaling by Leptin

Signaling by Leptin

	1074
set	Signaling by Leptin
setSize	10
pANOVA	0.0992
s.dist	0.301
p.adjustANOVA	0.738

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SH2B1	6044
SOCS3	5597
IRS2	5210
STAT5B	5000
LEPR	3040
STAT3	1761
PTPN11	828
IRS1	-1992
STAT5A	-2315
LEP	-3156

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SH2B1	6044
SOCS3	5597
IRS2	5210
STAT5B	5000
LEPR	3040
STAT3	1761
PTPN11	828
IRS1	-1992
STAT5A	-2315
LEP	-3156

---

FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes

	369
set	FOXO-mediated transcription of cell death genes
setSize	13
pANOVA	0.0629
s.dist	0.298
p.adjustANOVA	0.663

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FASLG	6416
FOXO3	5551
PINK1	4854
CITED2	4804
BCL2L11	3966
EP300	3608
STK11	1448
NFYA	1048
BCL6	129
NFYB	-8
NFYC	-490
CREBBP	-1444
FOXO4	-4149

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FASLG	6416
FOXO3	5551
PINK1	4854
CITED2	4804
BCL2L11	3966
EP300	3608
STK11	1448
NFYA	1048
BCL6	129
NFYB	-8
NFYC	-490
CREBBP	-1444
FOXO4	-4149

---

ERBB2 Activates PTK6 Signaling

ERBB2 Activates PTK6 Signaling

	322
set	ERBB2 Activates PTK6 Signaling
setSize	10
pANOVA	0.105
s.dist	-0.296
p.adjustANOVA	0.756

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EGF	-6839
PTK6	-6260
HBEGF	-5787
NRG2	-3665
EGFR	-3646
NRG4	-2290
NRG1	-2048
ERBB3	1914
NRG3	1984
ERBB2	5655

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EGF	-6839
PTK6	-6260
HBEGF	-5787
NRG2	-3665
EGFR	-3646
NRG4	-2290
NRG1	-2048
ERBB3	1914
NRG3	1984
ERBB2	5655

---

NOTCH2 intracellular domain regulates transcription

NOTCH2 intracellular domain regulates transcription

	680
set	NOTCH2 intracellular domain regulates transcription
setSize	10
pANOVA	0.106
s.dist	-0.295
p.adjustANOVA	0.758

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GZMB	-6928
RBPJ	-6504
MAML1	-5749
MAML2	-4307
FCER2	-3741
CREB1	-3255
HES5	-215
MAML3	2339
EP300	3608
HES1	3826

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GZMB	-6928
RBPJ	-6504
MAML1	-5749
MAML2	-4307
FCER2	-3741
CREB1	-3255
HES5	-215
MAML3	2339
EP300	3608
HES1	3826

---

Role of phospholipids in phagocytosis

Role of phospholipids in phagocytosis

	994
set	Role of phospholipids in phagocytosis
setSize	25
pANOVA	0.0109
s.dist	-0.294
p.adjustANOVA	0.415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGHG1	-6930.5
IGHG2	-6930.5
IGHG3	-6930.5
IGHG4	-6930.5
PLD2	-6805.0
CD3G	-6491.0
PRKCD	-4958.0
PLD3	-4631.0
PLA2G6	-4269.0
SYK	-3352.0
PIK3CA	-2828.0
FCGR1A	-2826.5
ITPR1	-1891.0
FCGR3A	-1886.5
CD247	-1556.0
PLD1	-1298.0
FCGR2A	-699.5
PIK3R2	152.0
PRKCE	1211.0
PIK3R1	1605.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGHG1	-6930.5
IGHG2	-6930.5
IGHG3	-6930.5
IGHG4	-6930.5
PLD2	-6805.0
CD3G	-6491.0
PRKCD	-4958.0
PLD3	-4631.0
PLA2G6	-4269.0
SYK	-3352.0
PIK3CA	-2828.0
FCGR1A	-2826.5
ITPR1	-1891.0
FCGR3A	-1886.5
CD247	-1556.0
PLD1	-1298.0
FCGR2A	-699.5
PIK3R2	152.0
PRKCE	1211.0
PIK3R1	1605.0
ITPR2	1813.0
PIK3CB	2164.0
ITPR3	3628.0
PLCG1	3989.0
AHCYL1	4551.0

---

TRAF6 mediated NF-kB activation

TRAF6 mediated NF-kB activation

	1177
set	TRAF6 mediated NF-kB activation
setSize	19
pANOVA	0.0271
s.dist	-0.293
p.adjustANOVA	0.454

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF2	-6821
NFKB2	-5993
MAVS	-5703
IFIH1	-5154
CHUK	-5021
NFKB1	-3934
NFKBIA	-3749
S100B	-3595
HMGB1	-3151
DDX58	-1641
RELA	-1241
IKBKB	-1079
TRAF6	-815
NKIRAS2	748
IKBKG	947
RNF135	1347
MAP3K1	1394
NFKBIB	1990
APP	2036

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF2	-6821
NFKB2	-5993
MAVS	-5703
IFIH1	-5154
CHUK	-5021
NFKB1	-3934
NFKBIA	-3749
S100B	-3595
HMGB1	-3151
DDX58	-1641
RELA	-1241
IKBKB	-1079
TRAF6	-815
NKIRAS2	748
IKBKG	947
RNF135	1347
MAP3K1	1394
NFKBIB	1990
APP	2036

---

PINK1-PRKN Mediated Mitophagy

PINK1-PRKN Mediated Mitophagy

	767
set	PINK1-PRKN Mediated Mitophagy
setSize	14
pANOVA	0.0579
s.dist	-0.293
p.adjustANOVA	0.663

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TOMM7	-6635.0
TOMM5	-6518.0
MFN1	-6221.0
MAP1LC3A	-5638.0
TOMM40	-4197.0
VDAC1	-3925.0
TOMM22	-2023.0
SQSTM1	-1459.0
MAP1LC3B	-524.5
ATG5	-249.0
MFN2	-76.0
UBA52	1318.0
PARK2	2246.0
PINK1	4854.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TOMM7	-6635.0
TOMM5	-6518.0
MFN1	-6221.0
MAP1LC3A	-5638.0
TOMM40	-4197.0
VDAC1	-3925.0
TOMM22	-2023.0
SQSTM1	-1459.0
MAP1LC3B	-524.5
ATG5	-249.0
MFN2	-76.0
UBA52	1318.0
PARK2	2246.0
PINK1	4854.0

---

Regulation of TNFR1 signaling

Regulation of TNFR1 signaling

	943
set	Regulation of TNFR1 signaling
setSize	25
pANOVA	0.0114
s.dist	-0.292
p.adjustANOVA	0.415

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF2	-6821.0
SPPL2A	-6589.0
RIPK1	-5913.0
TNF	-5773.0
RNF31	-5720.5
TAX1BP1	-5375.0
CASP8	-5315.0
CHUK	-5021.0
USP21	-4281.0
OTUD7B	-4059.0
USP2	-3726.0
RBCK1	-3287.0
TNFRSF1A	-2204.0
CYLD	-1729.0
BIRC3	-1172.0
IKBKB	-1079.0
TRADD	-657.0
MADD	254.0
IKBKG	947.0
UBA52	1318.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF2	-6821.0
SPPL2A	-6589.0
RIPK1	-5913.0
TNF	-5773.0
RNF31	-5720.5
TAX1BP1	-5375.0
CASP8	-5315.0
CHUK	-5021.0
USP21	-4281.0
OTUD7B	-4059.0
USP2	-3726.0
RBCK1	-3287.0
TNFRSF1A	-2204.0
CYLD	-1729.0
BIRC3	-1172.0
IKBKB	-1079.0
TRADD	-657.0
MADD	254.0
IKBKG	947.0
UBA52	1318.0
SHARPIN	1510.0
CLIP3	1517.0
TRAF1	3208.0
BIRC2	3813.0
TNFAIP3	4396.0

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] fgsea_1.14.0                gplots_3.0.3               
##  [9] DESeq2_1.28.1               SummarizedExperiment_1.18.1
## [11] DelayedArray_0.14.0         matrixStats_0.56.0         
## [13] Biobase_2.48.0              GenomicRanges_1.40.0       
## [15] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [17] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [19] reshape2_1.4.4              forcats_0.5.0              
## [21] stringr_1.4.0               dplyr_1.0.0                
## [23] purrr_0.3.4                 readr_1.3.1                
## [25] tidyr_1.1.0                 tibble_3.0.1               
## [27] ggplot2_3.3.2               tidyverse_1.3.0            
## [29] locfit_1.5-9.4              statmod_1.4.34             
## [31] plyr_1.8.6                 
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] farver_2.0.3           bit64_0.9-7            AnnotationDbi_1.50.1  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.29            
## [16] jsonlite_1.7.0         broom_0.5.6            annotate_1.66.0       
## [19] dbplyr_1.4.4           shiny_1.5.0            compiler_4.0.2        
## [22] httr_1.4.1             backports_1.1.8        assertthat_0.2.1      
## [25] Matrix_1.2-18          fastmap_1.0.1          cli_2.0.2             
## [28] later_1.1.0.1          prettyunits_1.1.1      htmltools_0.5.0       
## [31] tools_4.0.2            gtable_0.3.0           glue_1.4.1            
## [34] GenomeInfoDbData_1.2.3 fastmatch_1.1-0        Rcpp_1.0.4.6          
## [37] cellranger_1.1.0       vctrs_0.3.1            gdata_2.18.0          
## [40] nlme_3.1-148           xfun_0.15              testthat_2.3.2        
## [43] rvest_0.3.5            mime_0.9               lifecycle_0.2.0       
## [46] XML_3.99-0.3           zlibbioc_1.34.0        MASS_7.3-51.6         
## [49] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [52] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [55] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [58] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [61] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [64] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [67] evaluate_0.14          lattice_0.20-41        labeling_0.3          
## [70] htmlwidgets_1.5.1      bit_1.1-15.2           tidyselect_1.1.0      
## [73] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [76] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [79] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [82] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [85] rmarkdown_2.3          progress_1.2.2         grid_4.0.2            
## [88] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [91] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [94] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report