date generated: 2020-07-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                 x
## A2M     0.4967182
## A4GALT  1.1055218
## AAAS    2.1498692
## AACS   -0.8274404
## AADAT   2.7771694
## AAED1   1.1657765

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 13161
duplicated_genes_present 0
num_profile_genes_in_sets 7488
num_profile_genes_not_in_sets 5673

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1061
num_genesets_included 1339

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set setSize pANOVA s.dist p.adjustANOVA
Establishment of Sister Chromatid Cohesion 10 8.94e-05 0.715 1.48e-03
Unwinding of DNA 12 2.56e-05 0.702 5.12e-04
Mitotic Telophase/Cytokinesis 12 5.57e-05 0.672 1.04e-03
Viral mRNA Translation 55 4.87e-15 0.610 2.17e-12
Peptide chain elongation 55 1.22e-14 0.601 2.72e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency 65 2.69e-16 0.587 1.80e-13
Activation of the pre-replicative complex 31 1.94e-08 0.583 8.67e-07
Selenocysteine synthesis 58 6.68e-14 0.569 1.12e-11
Eukaryotic Translation Termination 58 1.86e-13 0.559 2.76e-11
Glucuronidation 11 1.35e-03 0.558 1.49e-02
Eukaryotic Translation Elongation 59 6.46e-13 0.541 7.21e-11
DNA strand elongation 32 1.24e-07 0.540 4.48e-06
Condensation of Prophase Chromosomes 13 8.83e-04 0.533 1.01e-02
Condensation of Prometaphase Chromosomes 11 2.38e-03 0.529 2.34e-02
Dissolution of Fibrin Clot 10 4.58e-03 0.518 3.90e-02
Polo-like kinase mediated events 15 5.45e-04 0.516 6.82e-03
Cyclin A/B1/B2 associated events during G2/M transition 22 3.20e-05 0.512 6.21e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 60 9.09e-12 0.509 5.53e-10
HSF1-dependent transactivation 32 6.86e-07 -0.507 2.14e-05
Formation of a pool of free 40S subunits 65 2.80e-12 0.501 2.34e-10
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 11 4.71e-03 -0.492 3.99e-02
Processive synthesis on the lagging strand 15 9.79e-04 0.492 1.10e-02
Activation of ATR in response to replication stress 35 6.51e-07 0.486 2.08e-05
SRP-dependent cotranslational protein targeting to membrane 76 5.63e-13 0.478 7.21e-11
L13a-mediated translational silencing of Ceruloplasmin expression 73 1.65e-12 0.478 1.55e-10
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 1.38e-03 0.477 1.51e-02
Selenoamino acid metabolism 72 3.56e-12 0.474 2.81e-10
GTP hydrolysis and joining of the 60S ribosomal subunit 75 1.74e-12 0.471 1.55e-10
Removal of the Flap Intermediate 14 2.31e-03 0.470 2.29e-02
LGI-ADAM interactions 11 7.18e-03 -0.468 5.29e-02
G0 and Early G1 25 6.17e-05 0.463 1.09e-03
Recognition of DNA damage by PCNA-containing replication complex 28 2.89e-05 0.457 5.70e-04
G1/S-Specific Transcription 26 6.73e-05 0.452 1.17e-03
Constitutive Signaling by NOTCH1 HD Domain Mutants 12 6.92e-03 -0.450 5.15e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 12 6.92e-03 -0.450 5.15e-02
Attenuation phase 22 2.67e-04 -0.449 3.73e-03
CDC6 association with the ORC:origin complex 10 1.43e-02 0.448 8.76e-02
Lagging Strand Synthesis 20 6.21e-04 0.442 7.63e-03
Cap-dependent Translation Initiation 81 6.39e-12 0.442 4.50e-10
Eukaryotic Translation Initiation 81 6.39e-12 0.442 4.50e-10
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 80 8.68e-12 0.442 5.53e-10
Nonsense-Mediated Decay (NMD) 80 8.68e-12 0.442 5.53e-10
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.25e-03 0.441 3.70e-02
PCNA-Dependent Long Patch Base Excision Repair 21 4.76e-04 0.441 6.13e-03
Formation of the ternary complex, and subsequently, the 43S complex 39 2.34e-06 0.437 5.69e-05
Synthesis of PE 11 1.31e-02 -0.432 8.34e-02
Glycogen storage diseases 11 1.36e-02 -0.430 8.54e-02
Interleukin-12 signaling 35 1.31e-05 0.426 2.79e-04
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 30 6.11e-05 0.423 1.09e-03
NCAM1 interactions 29 9.65e-05 -0.418 1.54e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Establishment of Sister Chromatid Cohesion 10 8.94e-05 7.15e-01 1.48e-03
Unwinding of DNA 12 2.56e-05 7.02e-01 5.12e-04
Mitotic Telophase/Cytokinesis 12 5.57e-05 6.72e-01 1.04e-03
Viral mRNA Translation 55 4.87e-15 6.10e-01 2.17e-12
Peptide chain elongation 55 1.22e-14 6.01e-01 2.72e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency 65 2.69e-16 5.87e-01 1.80e-13
Activation of the pre-replicative complex 31 1.94e-08 5.83e-01 8.67e-07
Selenocysteine synthesis 58 6.68e-14 5.69e-01 1.12e-11
Eukaryotic Translation Termination 58 1.86e-13 5.59e-01 2.76e-11
Glucuronidation 11 1.35e-03 5.58e-01 1.49e-02
Eukaryotic Translation Elongation 59 6.46e-13 5.41e-01 7.21e-11
DNA strand elongation 32 1.24e-07 5.40e-01 4.48e-06
Condensation of Prophase Chromosomes 13 8.83e-04 5.33e-01 1.01e-02
Condensation of Prometaphase Chromosomes 11 2.38e-03 5.29e-01 2.34e-02
Dissolution of Fibrin Clot 10 4.58e-03 5.18e-01 3.90e-02
Polo-like kinase mediated events 15 5.45e-04 5.16e-01 6.82e-03
Cyclin A/B1/B2 associated events during G2/M transition 22 3.20e-05 5.12e-01 6.21e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 60 9.09e-12 5.09e-01 5.53e-10
HSF1-dependent transactivation 32 6.86e-07 -5.07e-01 2.14e-05
Formation of a pool of free 40S subunits 65 2.80e-12 5.01e-01 2.34e-10
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 11 4.71e-03 -4.92e-01 3.99e-02
Processive synthesis on the lagging strand 15 9.79e-04 4.92e-01 1.10e-02
Activation of ATR in response to replication stress 35 6.51e-07 4.86e-01 2.08e-05
SRP-dependent cotranslational protein targeting to membrane 76 5.63e-13 4.78e-01 7.21e-11
L13a-mediated translational silencing of Ceruloplasmin expression 73 1.65e-12 4.78e-01 1.55e-10
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 1.38e-03 4.77e-01 1.51e-02
Selenoamino acid metabolism 72 3.56e-12 4.74e-01 2.81e-10
GTP hydrolysis and joining of the 60S ribosomal subunit 75 1.74e-12 4.71e-01 1.55e-10
Removal of the Flap Intermediate 14 2.31e-03 4.70e-01 2.29e-02
LGI-ADAM interactions 11 7.18e-03 -4.68e-01 5.29e-02
G0 and Early G1 25 6.17e-05 4.63e-01 1.09e-03
Recognition of DNA damage by PCNA-containing replication complex 28 2.89e-05 4.57e-01 5.70e-04
G1/S-Specific Transcription 26 6.73e-05 4.52e-01 1.17e-03
Constitutive Signaling by NOTCH1 HD Domain Mutants 12 6.92e-03 -4.50e-01 5.15e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 12 6.92e-03 -4.50e-01 5.15e-02
Attenuation phase 22 2.67e-04 -4.49e-01 3.73e-03
CDC6 association with the ORC:origin complex 10 1.43e-02 4.48e-01 8.76e-02
Lagging Strand Synthesis 20 6.21e-04 4.42e-01 7.63e-03
Cap-dependent Translation Initiation 81 6.39e-12 4.42e-01 4.50e-10
Eukaryotic Translation Initiation 81 6.39e-12 4.42e-01 4.50e-10
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 80 8.68e-12 4.42e-01 5.53e-10
Nonsense-Mediated Decay (NMD) 80 8.68e-12 4.42e-01 5.53e-10
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.25e-03 4.41e-01 3.70e-02
PCNA-Dependent Long Patch Base Excision Repair 21 4.76e-04 4.41e-01 6.13e-03
Formation of the ternary complex, and subsequently, the 43S complex 39 2.34e-06 4.37e-01 5.69e-05
Synthesis of PE 11 1.31e-02 -4.32e-01 8.34e-02
Glycogen storage diseases 11 1.36e-02 -4.30e-01 8.54e-02
Interleukin-12 signaling 35 1.31e-05 4.26e-01 2.79e-04
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 30 6.11e-05 4.23e-01 1.09e-03
NCAM1 interactions 29 9.65e-05 -4.18e-01 1.54e-03
Interferon alpha/beta signaling 45 1.53e-06 4.14e-01 4.01e-05
Collagen chain trimerization 33 3.91e-05 -4.14e-01 7.37e-04
P2Y receptors 10 2.35e-02 4.14e-01 1.27e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 46 1.32e-06 4.12e-01 3.67e-05
Ribosomal scanning and start codon recognition 46 1.40e-06 4.11e-01 3.84e-05
Transcription of E2F targets under negative control by DREAM complex 18 2.74e-03 4.08e-01 2.60e-02
Termination of translesion DNA synthesis 29 1.44e-04 4.08e-01 2.16e-03
E2F mediated regulation of DNA replication 20 1.67e-03 4.06e-01 1.78e-02
Leading Strand Synthesis 14 8.55e-03 4.06e-01 6.12e-02
Polymerase switching 14 8.55e-03 4.06e-01 6.12e-02
Translation initiation complex formation 45 3.30e-06 4.01e-01 7.88e-05
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 1.66e-02 3.99e-01 9.87e-02
Interleukin-12 family signaling 41 1.10e-05 3.97e-01 2.37e-04
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.13e-02 3.91e-01 7.58e-02
Acetylcholine regulates insulin secretion 10 3.45e-02 -3.86e-01 1.61e-01
Elevation of cytosolic Ca2+ levels 12 2.10e-02 -3.85e-01 1.17e-01
Termination of O-glycan biosynthesis 10 3.56e-02 -3.84e-01 1.64e-01
Mitotic G1 phase and G1/S transition 135 3.17e-14 3.79e-01 6.06e-12
Activation of AMPK downstream of NMDARs 10 3.85e-02 -3.78e-01 1.72e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.71e-03 3.78e-01 1.80e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 1.38e-03 3.77e-01 1.51e-02
Glycogen synthesis 12 2.37e-02 -3.77e-01 1.28e-01
G1/S Transition 119 1.39e-12 3.76e-01 1.44e-10
Assembly of collagen fibrils and other multimeric structures 46 1.03e-05 -3.76e-01 2.27e-04
DNA Damage Bypass 44 1.77e-05 3.74e-01 3.65e-04
Phosphorylation of CD3 and TCR zeta chains 11 3.25e-02 3.72e-01 1.56e-01
MASTL Facilitates Mitotic Progression 10 4.47e-02 3.67e-01 1.91e-01
Lysine catabolism 10 4.50e-02 3.66e-01 1.91e-01
S Phase 152 9.15e-15 3.65e-01 2.45e-12
DNA Replication Pre-Initiation 77 3.22e-08 3.65e-01 1.39e-06
ATF6 (ATF6-alpha) activates chaperone genes 10 4.67e-02 3.63e-01 1.97e-01
CD28 dependent Vav1 pathway 12 3.02e-02 3.61e-01 1.49e-01
Mismatch Repair 15 1.69e-02 3.56e-01 9.89e-02
Orc1 removal from chromatin 63 1.03e-06 3.56e-01 3.00e-05
Regulation of expression of SLITs and ROBOs 121 1.92e-11 3.54e-01 1.11e-09
DNA Replication 119 3.91e-11 3.51e-01 2.18e-09
Synthesis of DNA 112 1.57e-10 3.50e-01 8.41e-09
Effects of PIP2 hydrolysis 22 5.03e-03 -3.46e-01 4.24e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 6.12e-02 3.42e-01 2.36e-01
Activation of Matrix Metalloproteinases 17 1.47e-02 -3.42e-01 8.98e-02
Synthesis of PC 24 3.84e-03 -3.41e-01 3.43e-02
Metal ion SLC transporters 21 7.66e-03 3.36e-01 5.60e-02
Deposition of new CENPA-containing nucleosomes at the centromere 22 6.49e-03 3.35e-01 4.94e-02
Nucleosome assembly 22 6.49e-03 3.35e-01 4.94e-02
Signaling by Activin 11 5.49e-02 -3.34e-01 2.19e-01
Signaling by FGFR3 fusions in cancer 10 6.77e-02 3.34e-01 2.50e-01
Early Phase of HIV Life Cycle 13 3.77e-02 3.33e-01 1.70e-01
ATF6 (ATF6-alpha) activates chaperones 12 4.62e-02 3.32e-01 1.95e-01
Translesion synthesis by POLK 15 2.58e-02 3.32e-01 1.35e-01
Pre-NOTCH Processing in Golgi 16 2.18e-02 -3.31e-01 1.20e-01
Cholesterol biosynthesis 23 6.01e-03 -3.31e-01 4.76e-02
Synthesis of IP3 and IP4 in the cytosol 21 9.03e-03 -3.29e-01 6.40e-02
Translesion synthesis by REV1 14 3.34e-02 3.28e-01 1.59e-01
ERBB2 Activates PTK6 Signaling 10 7.22e-02 -3.28e-01 2.62e-01
Transcriptional Regulation by E2F6 33 1.17e-03 3.27e-01 1.30e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 8.51e-04 3.26e-01 9.82e-03
Purine salvage 12 5.19e-02 3.24e-01 2.11e-01
Collagen biosynthesis and modifying enzymes 52 5.90e-05 -3.22e-01 1.08e-03
Translesion synthesis by POLI 15 3.17e-02 3.20e-01 1.54e-01
ATF4 activates genes in response to endoplasmic reticulum stress 24 6.60e-03 3.20e-01 4.99e-02
Influenza Viral RNA Transcription and Replication 96 7.97e-08 3.17e-01 2.97e-06
Assembly of the pre-replicative complex 61 1.91e-05 3.17e-01 3.87e-04
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 4.87e-02 -3.16e-01 2.02e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 13 4.87e-02 -3.16e-01 2.02e-01
Interleukin-35 Signalling 10 8.53e-02 3.14e-01 2.91e-01
G2/M Checkpoints 124 1.84e-09 3.13e-01 9.48e-08
Transport of bile salts and organic acids, metal ions and amine compounds 51 1.13e-04 3.13e-01 1.75e-03
Formation of Fibrin Clot (Clotting Cascade) 17 2.63e-02 3.11e-01 1.37e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 1.36e-02 -3.11e-01 8.54e-02
Influenza Infection 112 1.73e-08 3.09e-01 8.00e-07
Phase II - Conjugation of compounds 72 6.80e-06 3.07e-01 1.54e-04
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 89 6.21e-07 3.06e-01 2.03e-05
Resolution of Sister Chromatid Cohesion 95 2.63e-07 3.06e-01 9.27e-06
Metabolism of Angiotensinogen to Angiotensins 12 6.68e-02 -3.06e-01 2.50e-01
Regulation of FZD by ubiquitination 13 5.76e-02 -3.04e-01 2.25e-01
Common Pathway of Fibrin Clot Formation 10 9.61e-02 3.04e-01 3.15e-01
Cyclin D associated events in G1 41 7.74e-04 3.04e-01 9.26e-03
G1 Phase 41 7.74e-04 3.04e-01 9.26e-03
Zinc transporters 13 5.95e-02 3.02e-01 2.31e-01
PERK regulates gene expression 28 5.73e-03 3.02e-01 4.65e-02
Collagen formation 72 1.38e-05 -2.96e-01 2.89e-04
Signaling by Leptin 10 1.06e-01 -2.96e-01 3.39e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 50 3.22e-04 2.94e-01 4.38e-03
Initial triggering of complement 19 2.68e-02 2.94e-01 1.38e-01
Switching of origins to a post-replicative state 83 4.12e-06 2.93e-01 9.67e-05
Telomere C-strand (Lagging Strand) Synthesis 33 3.68e-03 2.92e-01 3.30e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 6.92e-02 -2.91e-01 2.53e-01
Defective EXT2 causes exostoses 2 13 6.92e-02 -2.91e-01 2.53e-01
NF-kB is activated and signals survival 11 9.52e-02 -2.91e-01 3.12e-01
Polymerase switching on the C-strand of the telomere 25 1.22e-02 2.90e-01 8.03e-02
Free fatty acids regulate insulin secretion 10 1.15e-01 -2.88e-01 3.61e-01
Glycogen metabolism 23 1.70e-02 -2.88e-01 9.89e-02
HDR through Homologous Recombination (HRR) 61 1.08e-04 2.87e-01 1.70e-03
Regulation of IFNA signaling 12 8.71e-02 2.85e-01 2.96e-01
Heme degradation 10 1.19e-01 2.85e-01 3.65e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 8.82e-02 2.84e-01 2.98e-01
Removal of the Flap Intermediate from the C-strand 17 4.45e-02 2.82e-01 1.90e-01
Processive synthesis on the C-strand of the telomere 19 3.37e-02 2.81e-01 1.59e-01
Processing of DNA double-strand break ends 58 2.35e-04 2.79e-01 3.32e-03
Retrograde neurotrophin signalling 14 7.47e-02 -2.75e-01 2.66e-01
Cell Cycle Checkpoints 235 6.04e-13 2.73e-01 7.21e-11
Presynaptic phase of homologous DNA pairing and strand exchange 37 4.11e-03 2.73e-01 3.65e-02
Assembly of active LPL and LIPC lipase complexes 11 1.20e-01 -2.71e-01 3.65e-01
Homology Directed Repair 95 5.86e-06 2.69e-01 1.35e-04
Glutamate binding, activation of AMPA receptors and synaptic plasticity 26 1.76e-02 -2.69e-01 1.01e-01
Trafficking of AMPA receptors 26 1.76e-02 -2.69e-01 1.01e-01
Cyclin E associated events during G1/S transition 75 5.98e-05 2.68e-01 1.08e-03
Diseases of carbohydrate metabolism 27 1.60e-02 -2.68e-01 9.63e-02
CDT1 association with the CDC6:ORC:origin complex 52 8.43e-04 2.68e-01 9.82e-03
Protein methylation 11 1.25e-01 2.67e-01 3.78e-01
Major pathway of rRNA processing in the nucleolus and cytosol 141 5.45e-08 2.66e-01 2.15e-06
G2/M DNA damage checkpoint 58 5.03e-04 2.64e-01 6.41e-03
Platelet calcium homeostasis 22 3.26e-02 -2.63e-01 1.56e-01
Methylation 11 1.31e-01 2.63e-01 3.89e-01
WNT5A-dependent internalization of FZD4 15 7.82e-02 -2.63e-01 2.74e-01
Cyclin A:Cdk2-associated events at S phase entry 77 7.00e-05 2.62e-01 1.19e-03
Extension of Telomeres 48 1.76e-03 2.61e-01 1.82e-02
Signaling by WNT in cancer 28 1.69e-02 -2.61e-01 9.89e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 8.08e-02 2.60e-01 2.79e-01
rRNA processing in the nucleus and cytosol 150 4.27e-08 2.60e-01 1.79e-06
RET signaling 35 8.14e-03 -2.59e-01 5.89e-02
EPHB-mediated forward signaling 32 1.14e-02 2.58e-01 7.65e-02
KSRP (KHSRP) binds and destabilizes mRNA 16 7.44e-02 2.58e-01 2.66e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 2.38e-02 -2.56e-01 1.28e-01
Classical antibody-mediated complement activation 10 1.61e-01 2.56e-01 4.27e-01
Negative regulation of NOTCH4 signaling 48 2.16e-03 2.56e-01 2.16e-02
SCF(Skp2)-mediated degradation of p27/p21 52 1.41e-03 2.56e-01 1.53e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17 6.77e-02 2.56e-01 2.50e-01
PRC2 methylates histones and DNA 14 9.77e-02 2.56e-01 3.18e-01
Cross-presentation of soluble exogenous antigens (endosomes) 45 3.07e-03 2.55e-01 2.89e-02
Nucleotide-like (purinergic) receptors 13 1.13e-01 2.54e-01 3.55e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 1.13e-01 -2.54e-01 3.55e-01
FCGR activation 16 8.04e-02 2.53e-01 2.79e-01
Separation of Sister Chromatids 154 7.50e-08 2.52e-01 2.87e-06
Chromosome Maintenance 82 8.36e-05 2.52e-01 1.40e-03
Homologous DNA Pairing and Strand Exchange 40 6.33e-03 2.50e-01 4.94e-02
Metabolism of polyamines 53 1.80e-03 2.48e-01 1.84e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 70 3.44e-04 2.48e-01 4.60e-03
RA biosynthesis pathway 14 1.09e-01 2.47e-01 3.47e-01
NRAGE signals death through JNK 54 1.74e-03 -2.46e-01 1.82e-02
rRNA processing 167 4.72e-08 2.45e-01 1.91e-06
IL-6-type cytokine receptor ligand interactions 12 1.42e-01 2.45e-01 4.00e-01
APC/C-mediated degradation of cell cycle proteins 81 1.49e-04 2.44e-01 2.16e-03
Regulation of mitotic cell cycle 81 1.49e-04 2.44e-01 2.16e-03
Regulation of APC/C activators between G1/S and early anaphase 74 3.24e-04 2.42e-01 4.38e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 69 5.32e-04 2.41e-01 6.72e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 83 1.47e-04 2.41e-01 2.16e-03
Amplification of signal from the kinetochores 83 1.47e-04 2.41e-01 2.16e-03
HSF1 activation 24 4.14e-02 -2.41e-01 1.80e-01
Hyaluronan uptake and degradation 11 1.67e-01 2.41e-01 4.35e-01
Phosphorylation of the APC/C 20 6.33e-02 2.40e-01 2.41e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 25 3.81e-02 -2.40e-01 1.71e-01
Interferon gamma signaling 64 9.19e-04 2.40e-01 1.04e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 32 1.96e-02 2.39e-01 1.12e-01
STING mediated induction of host immune responses 12 1.54e-01 2.38e-01 4.13e-01
Cytosolic iron-sulfur cluster assembly 11 1.74e-01 -2.37e-01 4.43e-01
Generation of second messenger molecules 22 5.49e-02 2.37e-01 2.19e-01
NCAM signaling for neurite out-growth 49 4.22e-03 -2.36e-01 3.69e-02
Killing mechanisms 10 1.96e-01 -2.36e-01 4.78e-01
WNT5:FZD7-mediated leishmania damping 10 1.96e-01 -2.36e-01 4.78e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 67 8.44e-04 2.36e-01 9.82e-03
Biological oxidations 139 1.67e-06 2.36e-01 4.30e-05
Carnitine metabolism 12 1.58e-01 -2.36e-01 4.19e-01
Signaling by ERBB2 TMD/JMD mutants 19 7.85e-02 -2.33e-01 2.75e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 29 3.02e-02 2.33e-01 1.49e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.03e-01 -2.33e-01 4.88e-01
Metabolism of folate and pterines 15 1.19e-01 -2.32e-01 3.65e-01
Sema4D induced cell migration and growth-cone collapse 20 7.29e-02 -2.32e-01 2.63e-01
Activated NOTCH1 Transmits Signal to the Nucleus 26 4.15e-02 -2.31e-01 1.80e-01
ERBB2 Regulates Cell Motility 13 1.50e-01 -2.30e-01 4.10e-01
Mucopolysaccharidoses 11 1.87e-01 -2.30e-01 4.64e-01
PD-1 signaling 10 2.08e-01 2.30e-01 4.98e-01
CD28 co-stimulation 32 2.48e-02 2.29e-01 1.31e-01
Formation of the beta-catenin:TCF transactivating complex 30 2.98e-02 -2.29e-01 1.48e-01
Nicotinamide salvaging 14 1.38e-01 2.29e-01 3.99e-01
p75NTR signals via NF-kB 14 1.40e-01 -2.28e-01 3.99e-01
Collagen degradation 25 4.92e-02 -2.27e-01 2.03e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 66 1.46e-03 2.27e-01 1.56e-02
Diseases associated with N-glycosylation of proteins 16 1.17e-01 -2.26e-01 3.62e-01
RIP-mediated NFkB activation via ZBP1 17 1.07e-01 -2.26e-01 3.41e-01
Activation of RAC1 12 1.77e-01 2.25e-01 4.48e-01
Signaling by ROBO receptors 163 7.95e-07 2.25e-01 2.42e-05
Resolution of D-Loop Structures 30 3.37e-02 2.24e-01 1.59e-01
Trafficking of GluR2-containing AMPA receptors 15 1.33e-01 -2.24e-01 3.92e-01
Mitotic Spindle Checkpoint 100 1.13e-04 2.24e-01 1.75e-03
Voltage gated Potassium channels 26 4.85e-02 -2.24e-01 2.02e-01
Antigen processing-Cross presentation 83 4.57e-04 2.23e-01 5.95e-03
Activation of BAD and translocation to mitochondria 14 1.50e-01 2.22e-01 4.10e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.50e-01 -2.22e-01 4.10e-01
Presynaptic depolarization and calcium channel opening 11 2.02e-01 -2.22e-01 4.87e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 44 1.09e-02 2.22e-01 7.41e-02
Telomere Maintenance 62 2.55e-03 2.22e-01 2.47e-02
EML4 and NUDC in mitotic spindle formation 87 3.60e-04 2.22e-01 4.77e-03
Regulation of ornithine decarboxylase (ODC) 46 9.43e-03 2.21e-01 6.61e-02
Vif-mediated degradation of APOBEC3G 45 1.05e-02 2.21e-01 7.22e-02
RHO GTPases activate IQGAPs 10 2.28e-01 2.20e-01 5.16e-01
Laminin interactions 22 7.36e-02 -2.20e-01 2.64e-01
DAP12 signaling 25 5.74e-02 2.20e-01 2.25e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 14 1.55e-01 2.19e-01 4.16e-01
BBSome-mediated cargo-targeting to cilium 20 9.26e-02 2.17e-01 3.10e-01
Transferrin endocytosis and recycling 24 6.57e-02 -2.17e-01 2.48e-01
Uptake and actions of bacterial toxins 24 6.63e-02 -2.17e-01 2.49e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.14e-01 2.16e-01 5.03e-01
Ion homeostasis 42 1.53e-02 -2.16e-01 9.31e-02
Vpu mediated degradation of CD4 46 1.15e-02 2.16e-01 7.66e-02
Trafficking and processing of endosomal TLR 11 2.17e-01 2.15e-01 5.05e-01
Nitric oxide stimulates guanylate cyclase 19 1.06e-01 -2.14e-01 3.39e-01
Ub-specific processing proteases 165 2.21e-06 2.14e-01 5.47e-05
HDR through Single Strand Annealing (SSA) 36 2.63e-02 2.14e-01 1.37e-01
Cell Cycle, Mitotic 458 6.70e-15 2.14e-01 2.24e-12
Costimulation by the CD28 family 55 6.17e-03 2.14e-01 4.86e-02
Interferon Signaling 146 9.07e-06 2.13e-01 2.02e-04
Non-integrin membrane-ECM interactions 40 1.99e-02 -2.13e-01 1.13e-01
Diseases associated with glycosylation precursor biosynthesis 18 1.19e-01 -2.13e-01 3.64e-01
PKA activation in glucagon signalling 16 1.41e-01 -2.12e-01 4.00e-01
Nonhomologous End-Joining (NHEJ) 33 3.51e-02 2.12e-01 1.63e-01
Ubiquitin-dependent degradation of Cyclin D 46 1.32e-02 2.11e-01 8.35e-02
SCF-beta-TrCP mediated degradation of Emi1 49 1.06e-02 2.11e-01 7.29e-02
Organic cation/anion/zwitterion transport 10 2.49e-01 2.10e-01 5.43e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 49 1.11e-02 2.10e-01 7.53e-02
Mitochondrial iron-sulfur cluster biogenesis 12 2.10e-01 -2.09e-01 5.01e-01
Selective autophagy 53 8.82e-03 -2.08e-01 6.29e-02
MECP2 regulates neuronal receptors and channels 12 2.12e-01 2.08e-01 5.03e-01
DNA Double-Strand Break Repair 123 6.98e-05 2.08e-01 1.19e-03
Heme biosynthesis 13 1.95e-01 -2.08e-01 4.77e-01
Metabolism of amino acids and derivatives 260 9.17e-09 2.08e-01 4.55e-07
CDK-mediated phosphorylation and removal of Cdc6 66 3.60e-03 2.07e-01 3.25e-02
RHO GTPases Activate WASPs and WAVEs 35 3.40e-02 2.07e-01 1.60e-01
Cellular hexose transport 12 2.14e-01 -2.07e-01 5.03e-01
GAB1 signalosome 14 1.80e-01 -2.07e-01 4.53e-01
Stimuli-sensing channels 58 6.70e-03 -2.06e-01 5.04e-02
MicroRNA (miRNA) biogenesis 23 8.75e-02 -2.06e-01 2.97e-01
Glucagon-type ligand receptors 17 1.42e-01 -2.06e-01 4.00e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 2.38e-01 -2.06e-01 5.31e-01
Citric acid cycle (TCA cycle) 22 9.51e-02 2.06e-01 3.12e-01
Degradation of AXIN 49 1.30e-02 2.05e-01 8.32e-02
MET activates PTK2 signaling 17 1.43e-01 -2.05e-01 4.02e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 16 1.57e-01 -2.04e-01 4.18e-01
Stabilization of p53 50 1.28e-02 2.04e-01 8.25e-02
Synthesis of PA 25 7.93e-02 -2.03e-01 2.76e-01
DARPP-32 events 22 9.99e-02 2.03e-01 3.24e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 18 1.38e-01 -2.02e-01 3.99e-01
Cell Cycle 571 2.60e-16 2.02e-01 1.80e-13
Signaling by PDGFRA extracellular domain mutants 12 2.26e-01 2.02e-01 5.15e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.26e-01 2.02e-01 5.15e-01
Regulation of Complement cascade 33 4.57e-02 2.01e-01 1.94e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 68 4.39e-03 2.00e-01 3.77e-02
GRB2 events in EGFR signaling 10 2.74e-01 -2.00e-01 5.63e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 2.74e-01 -2.00e-01 5.63e-01
EGFR downregulation 26 7.82e-02 -2.00e-01 2.74e-01
ER-Phagosome pathway 69 4.29e-03 1.99e-01 3.70e-02
HS-GAG degradation 19 1.34e-01 -1.99e-01 3.93e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 1.69e-01 -1.99e-01 4.38e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.25e-01 -1.98e-01 3.78e-01
Nucleotide salvage 21 1.16e-01 1.98e-01 3.61e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 46 2.02e-02 1.98e-01 1.13e-01
p53-Independent DNA Damage Response 46 2.02e-02 1.98e-01 1.13e-01
p53-Independent G1/S DNA damage checkpoint 46 2.02e-02 1.98e-01 1.13e-01
Mitotic Metaphase and Anaphase 207 1.01e-06 1.98e-01 3.00e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 57 1.01e-02 1.97e-01 7.02e-02
IRF3-mediated induction of type I IFN 10 2.81e-01 1.97e-01 5.70e-01
Defective CFTR causes cystic fibrosis 52 1.41e-02 1.97e-01 8.73e-02
Extracellular matrix organization 223 4.98e-07 -1.96e-01 1.67e-05
CS/DS degradation 11 2.62e-01 -1.95e-01 5.56e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 54 1.32e-02 1.95e-01 8.35e-02
Energy dependent regulation of mTOR by LKB1-AMPK 29 6.91e-02 -1.95e-01 2.53e-01
APC/C:Cdc20 mediated degradation of Securin 62 7.99e-03 1.95e-01 5.82e-02
Mitotic Anaphase 206 1.52e-06 1.95e-01 4.01e-05
TCR signaling 99 8.42e-04 1.94e-01 9.82e-03
Defective B4GALT7 causes EDS, progeroid type 17 1.65e-01 -1.94e-01 4.33e-01
Glutathione conjugation 30 6.73e-02 1.93e-01 2.50e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 15 1.96e-01 -1.93e-01 4.78e-01
Meiotic synapsis 27 8.48e-02 1.92e-01 2.91e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.72e-01 1.91e-01 4.42e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.72e-01 1.91e-01 4.42e-01
Peroxisomal lipid metabolism 26 9.26e-02 1.91e-01 3.10e-01
Signaling by PDGF 47 2.42e-02 -1.90e-01 1.28e-01
p53-Dependent G1 DNA Damage Response 58 1.24e-02 1.90e-01 8.04e-02
p53-Dependent G1/S DNA damage checkpoint 58 1.24e-02 1.90e-01 8.04e-02
G alpha (12/13) signalling events 71 5.94e-03 -1.89e-01 4.73e-02
Regulation of IFNG signaling 13 2.38e-01 1.89e-01 5.32e-01
Ion channel transport 110 6.56e-04 -1.88e-01 7.98e-03
G1/S DNA Damage Checkpoints 60 1.17e-02 1.88e-01 7.77e-02
TRAF6 mediated IRF7 activation 15 2.09e-01 1.87e-01 5.00e-01
Binding and Uptake of Ligands by Scavenger Receptors 31 7.15e-02 -1.87e-01 2.60e-01
Regulation of RAS by GAPs 60 1.24e-02 1.87e-01 8.04e-02
Membrane binding and targetting of GAG proteins 11 2.84e-01 -1.87e-01 5.72e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 11 2.84e-01 -1.87e-01 5.72e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.39e-01 1.87e-01 3.99e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.39e-01 1.87e-01 3.99e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 1.30e-01 1.86e-01 3.87e-01
Cristae formation 11 2.85e-01 1.86e-01 5.72e-01
Biosynthesis of specialized proresolving mediators (SPMs) 14 2.28e-01 1.86e-01 5.16e-01
Aquaporin-mediated transport 37 5.04e-02 -1.86e-01 2.06e-01
Autodegradation of the E3 ubiquitin ligase COP1 46 2.99e-02 1.85e-01 1.48e-01
RHO GTPases Activate NADPH Oxidases 19 1.63e-01 1.85e-01 4.29e-01
O-glycosylation of TSR domain-containing proteins 32 7.05e-02 -1.85e-01 2.57e-01
SUMOylation of DNA replication proteins 40 4.33e-02 1.85e-01 1.86e-01
Creation of C4 and C2 activators 12 2.68e-01 1.85e-01 5.58e-01
Initiation of Nuclear Envelope (NE) Reformation 19 1.63e-01 1.85e-01 4.30e-01
Deadenylation of mRNA 24 1.18e-01 1.85e-01 3.62e-01
A tetrasaccharide linker sequence is required for GAG synthesis 21 1.43e-01 -1.85e-01 4.02e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 1.18e-01 1.85e-01 3.62e-01
DAP12 interactions 28 9.29e-02 1.84e-01 3.10e-01
Arachidonic acid metabolism 38 5.04e-02 1.83e-01 2.06e-01
Deubiquitination 238 1.21e-06 1.83e-01 3.44e-05
Regulation of Apoptosis 47 2.99e-02 1.83e-01 1.48e-01
Downstream TCR signaling 78 5.26e-03 1.83e-01 4.40e-02
Resolution of Abasic Sites (AP sites) 37 5.46e-02 1.83e-01 2.19e-01
Mitotic Prometaphase 175 3.55e-05 1.82e-01 6.79e-04
Interleukin-6 family signaling 18 1.82e-01 1.82e-01 4.57e-01
Ca2+ pathway 54 2.15e-02 -1.81e-01 1.19e-01
SHC-mediated cascade:FGFR1 12 2.80e-01 1.80e-01 5.68e-01
Scavenging by Class A Receptors 14 2.46e-01 -1.79e-01 5.42e-01
Inactivation, recovery and regulation of the phototransduction cascade 19 1.77e-01 -1.79e-01 4.48e-01
The phototransduction cascade 19 1.77e-01 -1.79e-01 4.48e-01
HS-GAG biosynthesis 23 1.38e-01 -1.79e-01 3.99e-01
Class B/2 (Secretin family receptors) 45 3.83e-02 -1.79e-01 1.72e-01
Dual Incision in GG-NER 39 5.39e-02 1.79e-01 2.17e-01
Post-chaperonin tubulin folding pathway 17 2.03e-01 -1.78e-01 4.88e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 31 8.61e-02 -1.78e-01 2.93e-01
Signaling by the B Cell Receptor (BCR) 104 1.77e-03 1.78e-01 1.82e-02
TRAF6 mediated NF-kB activation 22 1.52e-01 -1.77e-01 4.12e-01
Diseases associated with the TLR signaling cascade 22 1.52e-01 -1.76e-01 4.12e-01
Diseases of Immune System 22 1.52e-01 -1.76e-01 4.12e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.54e-01 1.76e-01 5.50e-01
Signaling by EGFR in Cancer 20 1.73e-01 -1.76e-01 4.43e-01
Antimicrobial peptides 14 2.56e-01 1.76e-01 5.50e-01
Defects in vitamin and cofactor metabolism 19 1.86e-01 -1.75e-01 4.64e-01
Peptide hormone metabolism 54 2.67e-02 -1.74e-01 1.38e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 34 7.91e-02 -1.74e-01 2.76e-01
Degradation of GLI1 by the proteasome 53 2.86e-02 1.74e-01 1.45e-01
Integration of energy metabolism 91 4.18e-03 -1.74e-01 3.68e-02
Activation of gene expression by SREBF (SREBP) 41 5.43e-02 -1.74e-01 2.18e-01
HDMs demethylate histones 21 1.70e-01 -1.73e-01 4.39e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 22 1.61e-01 -1.73e-01 4.27e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 5.60e-02 -1.73e-01 2.22e-01
Cellular response to heat stress 87 5.58e-03 -1.72e-01 4.59e-02
DAG and IP3 signaling 39 6.31e-02 -1.72e-01 2.41e-01
Glutathione synthesis and recycling 11 3.26e-01 1.71e-01 6.26e-01
Base Excision Repair 45 4.71e-02 1.71e-01 1.98e-01
Translation of structural proteins 26 1.32e-01 -1.71e-01 3.91e-01
Cytochrome c-mediated apoptotic response 10 3.50e-01 -1.71e-01 6.56e-01
Caspase activation via extrinsic apoptotic signalling pathway 24 1.50e-01 -1.70e-01 4.10e-01
Cell-extracellular matrix interactions 16 2.40e-01 -1.70e-01 5.34e-01
Complement cascade 37 7.45e-02 1.70e-01 2.66e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 2.90e-01 1.69e-01 5.79e-01
Degradation of DVL 50 3.87e-02 1.69e-01 1.72e-01
APC-Cdc20 mediated degradation of Nek2A 24 1.53e-01 1.69e-01 4.13e-01
Interleukin-10 signaling 26 1.40e-01 1.67e-01 3.99e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 33 9.65e-02 -1.67e-01 3.15e-01
GLI3 is processed to GLI3R by the proteasome 52 3.73e-02 1.67e-01 1.69e-01
Uptake and function of anthrax toxins 11 3.40e-01 -1.66e-01 6.43e-01
Regulation of RUNX2 expression and activity 64 2.16e-02 1.66e-01 1.19e-01
Pre-NOTCH Expression and Processing 47 4.93e-02 -1.66e-01 2.03e-01
Regulation of TP53 Activity through Methylation 14 2.83e-01 -1.66e-01 5.72e-01
Defective B3GAT3 causes JDSSDHD 17 2.41e-01 -1.64e-01 5.35e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 62 2.56e-02 1.64e-01 1.35e-01
NIK-->noncanonical NF-kB signaling 52 4.11e-02 1.64e-01 1.79e-01
The NLRP3 inflammasome 14 2.89e-01 -1.64e-01 5.79e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 48 5.03e-02 1.63e-01 2.06e-01
Autodegradation of Cdh1 by Cdh1:APC/C 58 3.18e-02 1.63e-01 1.54e-01
Regulation of RUNX3 expression and activity 48 5.11e-02 1.63e-01 2.08e-01
PI3K events in ERBB2 signaling 14 2.94e-01 -1.62e-01 5.84e-01
Degradation of the extracellular matrix 73 1.69e-02 -1.62e-01 9.89e-02
GRB2 events in ERBB2 signaling 14 2.96e-01 -1.61e-01 5.86e-01
Visual phototransduction 54 4.05e-02 -1.61e-01 1.77e-01
p38MAPK events 12 3.34e-01 1.61e-01 6.35e-01
Glycerophospholipid biosynthesis 96 6.42e-03 -1.61e-01 4.94e-02
Role of LAT2/NTAL/LAB on calcium mobilization 14 2.98e-01 1.61e-01 5.90e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 22 1.97e-01 -1.59e-01 4.78e-01
NGF-stimulated transcription 34 1.09e-01 -1.59e-01 3.46e-01
Global Genome Nucleotide Excision Repair (GG-NER) 80 1.41e-02 1.59e-01 8.73e-02
Phase I - Functionalization of compounds 63 2.93e-02 1.59e-01 1.48e-01
Thromboxane signalling through TP receptor 20 2.19e-01 -1.59e-01 5.08e-01
FCGR3A-mediated phagocytosis 61 3.28e-02 1.58e-01 1.56e-01
Leishmania phagocytosis 61 3.28e-02 1.58e-01 1.56e-01
Parasite infection 61 3.28e-02 1.58e-01 1.56e-01
Miscellaneous transport and binding events 19 2.33e-01 -1.58e-01 5.24e-01
Antiviral mechanism by IFN-stimulated genes 70 2.27e-02 1.58e-01 1.23e-01
Activation of SMO 14 3.07e-01 -1.58e-01 6.05e-01
p75NTR recruits signalling complexes 11 3.66e-01 -1.57e-01 6.78e-01
Processing of Intronless Pre-mRNAs 17 2.62e-01 1.57e-01 5.56e-01
Interleukin-6 signaling 10 3.89e-01 1.57e-01 6.98e-01
Assembly Of The HIV Virion 13 3.28e-01 -1.57e-01 6.27e-01
Acyl chain remodelling of PE 16 2.79e-01 1.56e-01 5.68e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 61 3.51e-02 1.56e-01 1.63e-01
Olfactory Signaling Pathway 14 3.12e-01 -1.56e-01 6.08e-01
Regulation of insulin secretion 64 3.09e-02 -1.56e-01 1.51e-01
Signaling by ERBB2 ECD mutants 15 2.95e-01 -1.56e-01 5.86e-01
Regulation of TLR by endogenous ligand 10 3.94e-01 -1.56e-01 6.98e-01
Hh mutants abrogate ligand secretion 50 5.69e-02 1.56e-01 2.23e-01
Chemokine receptors bind chemokines 30 1.40e-01 1.56e-01 3.99e-01
RAB geranylgeranylation 49 5.98e-02 1.56e-01 2.31e-01
Downregulation of ERBB2 signaling 24 1.87e-01 -1.55e-01 4.64e-01
COPII-mediated vesicle transport 59 3.92e-02 -1.55e-01 1.74e-01
Cell death signalling via NRAGE, NRIF and NADE 68 2.70e-02 -1.55e-01 1.38e-01
M Phase 323 1.84e-06 1.55e-01 4.64e-05
RHO GTPases Activate Formins 109 5.35e-03 1.55e-01 4.45e-02
Adherens junctions interactions 14 3.19e-01 -1.54e-01 6.18e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 17 2.73e-01 -1.53e-01 5.63e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 17 2.73e-01 -1.53e-01 5.63e-01
FGFR2 mutant receptor activation 23 2.03e-01 -1.53e-01 4.88e-01
Degradation of GLI2 by the proteasome 52 5.66e-02 1.53e-01 2.23e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 48 6.70e-02 1.53e-01 2.50e-01
Downstream signaling events of B Cell Receptor (BCR) 73 2.40e-02 1.53e-01 1.28e-01
Diseases of metabolism 181 4.02e-04 -1.53e-01 5.28e-03
SUMOylation of intracellular receptors 26 1.78e-01 1.53e-01 4.50e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 14 3.23e-01 -1.53e-01 6.23e-01
Adenylate cyclase activating pathway 10 4.04e-01 -1.52e-01 7.07e-01
Ion transport by P-type ATPases 36 1.16e-01 -1.52e-01 3.61e-01
Meiosis 47 7.29e-02 1.51e-01 2.63e-01
Telomere C-strand synthesis initiation 12 3.66e-01 1.51e-01 6.78e-01
Signaling by EGFR 45 8.12e-02 -1.50e-01 2.80e-01
ABC transporter disorders 63 3.94e-02 1.50e-01 1.74e-01
Signaling by ERBB2 KD Mutants 22 2.24e-01 -1.50e-01 5.12e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 23 2.14e-01 -1.50e-01 5.03e-01
mRNA 3'-end processing 52 6.26e-02 1.49e-01 2.40e-01
Diseases of glycosylation 112 6.44e-03 -1.49e-01 4.94e-02
SHC1 events in ERBB2 signaling 20 2.49e-01 -1.49e-01 5.43e-01
Meiotic recombination 22 2.27e-01 1.49e-01 5.16e-01
Post-translational protein phosphorylation 72 2.95e-02 -1.49e-01 1.48e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 3.20e-01 1.48e-01 6.19e-01
Inflammasomes 19 2.64e-01 -1.48e-01 5.58e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 12 3.75e-01 -1.48e-01 6.86e-01
Defects in cobalamin (B12) metabolism 11 3.96e-01 -1.48e-01 6.98e-01
Dectin-1 mediated noncanonical NF-kB signaling 53 6.36e-02 1.47e-01 2.41e-01
Sema4D in semaphorin signaling 24 2.12e-01 -1.47e-01 5.03e-01
tRNA Aminoacylation 24 2.13e-01 -1.47e-01 5.03e-01
Signaling by FGFR4 in disease 10 4.22e-01 1.47e-01 7.21e-01
CD28 dependent PI3K/Akt signaling 21 2.46e-01 1.46e-01 5.42e-01
SUMOylation 150 2.04e-03 1.46e-01 2.06e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 34 1.40e-01 -1.46e-01 3.99e-01
CaM pathway 33 1.46e-01 -1.46e-01 4.07e-01
Calmodulin induced events 33 1.46e-01 -1.46e-01 4.07e-01
SUMO E3 ligases SUMOylate target proteins 144 2.56e-03 1.46e-01 2.47e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 3.82e-01 -1.46e-01 6.94e-01
Phase 2 - plateau phase 19 2.73e-01 -1.45e-01 5.63e-01
Formation of the Early Elongation Complex 32 1.56e-01 -1.45e-01 4.16e-01
Formation of the HIV-1 Early Elongation Complex 32 1.56e-01 -1.45e-01 4.16e-01
ER to Golgi Anterograde Transport 121 5.94e-03 -1.45e-01 4.73e-02
UCH proteinases 78 2.71e-02 1.45e-01 1.38e-01
PI-3K cascade:FGFR1 12 3.85e-01 1.45e-01 6.95e-01
Regulation of PTEN mRNA translation 11 4.06e-01 -1.45e-01 7.07e-01
Post NMDA receptor activation events 55 6.38e-02 -1.45e-01 2.41e-01
Intra-Golgi traffic 40 1.16e-01 -1.44e-01 3.61e-01
Glycosphingolipid metabolism 34 1.47e-01 -1.44e-01 4.09e-01
Translesion Synthesis by POLH 16 3.20e-01 1.44e-01 6.19e-01
Activated NTRK2 signals through FRS2 and FRS3 10 4.33e-01 -1.43e-01 7.27e-01
FCERI mediated NF-kB activation 72 3.60e-02 1.43e-01 1.66e-01
Listeria monocytogenes entry into host cells 17 3.08e-01 -1.43e-01 6.06e-01
Plasma lipoprotein remodeling 15 3.40e-01 -1.42e-01 6.43e-01
SHC1 events in EGFR signaling 11 4.14e-01 -1.42e-01 7.17e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.40e-01 1.42e-01 3.99e-01
Diseases of mitotic cell cycle 36 1.40e-01 1.42e-01 3.99e-01
Regulation of TP53 Degradation 32 1.65e-01 1.42e-01 4.32e-01
Platelet homeostasis 71 3.93e-02 -1.42e-01 1.74e-01
RNA Polymerase II Transcription Termination 61 5.65e-02 1.41e-01 2.23e-01
Metalloprotease DUBs 18 3.00e-01 1.41e-01 5.92e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 75 3.65e-02 1.40e-01 1.67e-01
Mitochondrial tRNA aminoacylation 18 3.05e-01 -1.40e-01 6.01e-01
Unblocking of NMDA receptors, glutamate binding and activation 15 3.49e-01 -1.40e-01 6.55e-01
Deadenylation-dependent mRNA decay 54 7.62e-02 1.40e-01 2.68e-01
Telomere Extension By Telomerase 21 2.68e-01 1.40e-01 5.58e-01
Dual incision in TC-NER 62 5.78e-02 1.39e-01 2.25e-01
DNA Repair 267 9.38e-05 1.39e-01 1.53e-03
Biosynthesis of DHA-derived SPMs 12 4.03e-01 1.39e-01 7.07e-01
Keratan sulfate/keratin metabolism 26 2.22e-01 -1.39e-01 5.12e-01
Insulin processing 21 2.72e-01 -1.38e-01 5.63e-01
Translation 230 3.17e-04 1.38e-01 4.38e-03
Cytosolic sulfonation of small molecules 15 3.54e-01 1.38e-01 6.62e-01
Cell junction organization 51 8.83e-02 -1.38e-01 2.98e-01
FCERI mediated Ca+2 mobilization 27 2.15e-01 1.38e-01 5.03e-01
Thrombin signalling through proteinase activated receptors (PARs) 26 2.24e-01 -1.38e-01 5.12e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 3.56e-01 -1.38e-01 6.65e-01
Regulation of actin dynamics for phagocytic cup formation 63 5.99e-02 1.37e-01 2.31e-01
Metabolism of RNA 601 1.43e-08 1.37e-01 6.86e-07
Signaling by NOTCH4 74 4.30e-02 1.36e-01 1.86e-01
Peroxisomal protein import 55 8.12e-02 1.36e-01 2.80e-01
IRE1alpha activates chaperones 49 9.97e-02 -1.36e-01 3.24e-01
DCC mediated attractive signaling 13 3.97e-01 1.36e-01 6.98e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 4.57e-01 -1.36e-01 7.47e-01
Processing of Capped Intronless Pre-mRNA 26 2.32e-01 1.35e-01 5.24e-01
Incretin synthesis, secretion, and inactivation 12 4.18e-01 -1.35e-01 7.19e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 78 3.96e-02 -1.35e-01 1.74e-01
Regulation of PTEN stability and activity 62 6.71e-02 1.35e-01 2.50e-01
Amino acid transport across the plasma membrane 23 2.66e-01 1.34e-01 5.58e-01
Elastic fibre formation 38 1.53e-01 -1.34e-01 4.13e-01
Diseases associated with O-glycosylation of proteins 44 1.25e-01 -1.34e-01 3.78e-01
Interleukin-2 family signaling 34 1.80e-01 1.33e-01 4.53e-01
Glycogen breakdown (glycogenolysis) 14 3.90e-01 -1.33e-01 6.98e-01
PKA activation 17 3.45e-01 -1.32e-01 6.49e-01
Host Interactions of HIV factors 112 1.68e-02 1.31e-01 9.89e-02
Rho GTPase cycle 129 1.04e-02 -1.31e-01 7.22e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 103 2.20e-02 1.31e-01 1.20e-01
Regulated proteolysis of p75NTR 11 4.53e-01 -1.31e-01 7.44e-01
G2/M Transition 173 3.13e-03 1.31e-01 2.93e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 2.70e-01 1.30e-01 5.59e-01
Physiological factors 11 4.55e-01 -1.30e-01 7.45e-01
PLC beta mediated events 49 1.15e-01 -1.30e-01 3.61e-01
CLEC7A (Dectin-1) induces NFAT activation 10 4.77e-01 1.30e-01 7.56e-01
Infection with Mycobacterium tuberculosis 23 2.82e-01 1.30e-01 5.70e-01
activated TAK1 mediates p38 MAPK activation 18 3.42e-01 -1.29e-01 6.45e-01
Activation of NF-kappaB in B cells 61 8.15e-02 1.29e-01 2.80e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 4.21e-01 -1.29e-01 7.21e-01
G beta:gamma signalling through PLC beta 16 3.73e-01 -1.29e-01 6.85e-01
Mitotic G2-G2/M phases 175 3.43e-03 1.29e-01 3.13e-02
XBP1(S) activates chaperone genes 47 1.28e-01 -1.28e-01 3.82e-01
Sema3A PAK dependent Axon repulsion 16 3.74e-01 -1.28e-01 6.85e-01
PECAM1 interactions 11 4.61e-01 1.28e-01 7.48e-01
Disorders of developmental biology 11 4.62e-01 1.28e-01 7.48e-01
Loss of function of MECP2 in Rett syndrome 11 4.62e-01 1.28e-01 7.48e-01
Pervasive developmental disorders 11 4.62e-01 1.28e-01 7.48e-01
Smooth Muscle Contraction 36 1.86e-01 -1.27e-01 4.64e-01
Respiratory electron transport 97 3.04e-02 1.27e-01 1.49e-01
mRNA decay by 3' to 5' exoribonuclease 15 3.94e-01 1.27e-01 6.98e-01
The canonical retinoid cycle in rods (twilight vision) 10 4.87e-01 -1.27e-01 7.65e-01
Gluconeogenesis 27 2.54e-01 -1.27e-01 5.50e-01
InlB-mediated entry of Listeria monocytogenes into host cell 13 4.29e-01 -1.27e-01 7.23e-01
Constitutive Signaling by EGFRvIII 15 3.97e-01 -1.26e-01 6.98e-01
Signaling by EGFRvIII in Cancer 15 3.97e-01 -1.26e-01 6.98e-01
Prolactin receptor signaling 11 4.68e-01 -1.26e-01 7.53e-01
Negative regulators of DDX58/IFIH1 signaling 30 2.33e-01 1.26e-01 5.24e-01
Deactivation of the beta-catenin transactivating complex 35 1.98e-01 -1.26e-01 4.80e-01
Adaptive Immune System 585 2.82e-07 1.25e-01 9.68e-06
RHO GTPases activate KTN1 10 4.93e-01 -1.25e-01 7.67e-01
Nucleotide Excision Repair 105 2.71e-02 1.25e-01 1.38e-01
TP53 Regulates Transcription of Cell Cycle Genes 46 1.43e-01 1.25e-01 4.02e-01
NR1H2 and NR1H3-mediated signaling 37 1.89e-01 -1.25e-01 4.66e-01
Ephrin signaling 19 3.47e-01 -1.25e-01 6.52e-01
Pentose phosphate pathway 13 4.37e-01 1.24e-01 7.29e-01
mRNA Splicing - Major Pathway 168 5.65e-03 1.24e-01 4.61e-02
Kinesins 38 1.86e-01 1.24e-01 4.64e-01
Apoptotic factor-mediated response 13 4.40e-01 -1.24e-01 7.32e-01
Signaling by FGFR2 IIIa TM 18 3.64e-01 -1.24e-01 6.77e-01
mRNA Capping 28 2.61e-01 -1.23e-01 5.56e-01
Cellular response to hypoxia 64 9.08e-02 1.22e-01 3.06e-01
Syndecan interactions 20 3.44e-01 -1.22e-01 6.48e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 3.83e-01 -1.22e-01 6.94e-01
G-protein mediated events 50 1.36e-01 -1.22e-01 3.97e-01
Neurexins and neuroligins 38 1.94e-01 -1.22e-01 4.77e-01
Chondroitin sulfate/dermatan sulfate metabolism 42 1.73e-01 -1.22e-01 4.43e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 2.24e-01 -1.21e-01 5.12e-01
SHC-mediated cascade:FGFR3 12 4.69e-01 1.21e-01 7.54e-01
Chondroitin sulfate biosynthesis 16 4.04e-01 -1.21e-01 7.07e-01
RHO GTPase Effectors 220 2.13e-03 1.21e-01 2.14e-02
Reproduction 57 1.17e-01 1.20e-01 3.62e-01
Macroautophagy 104 3.48e-02 -1.20e-01 1.63e-01
Regulation of KIT signaling 16 4.06e-01 1.20e-01 7.07e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 3.79e-01 -1.20e-01 6.92e-01
mRNA Splicing 176 6.37e-03 1.20e-01 4.94e-02
SUMOylation of DNA damage response and repair proteins 66 9.44e-02 1.19e-01 3.11e-01
Synaptic adhesion-like molecules 17 3.96e-01 -1.19e-01 6.98e-01
Mitochondrial Fatty Acid Beta-Oxidation 32 2.47e-01 1.18e-01 5.42e-01
Signaling by ERBB2 in Cancer 23 3.26e-01 -1.18e-01 6.27e-01
Glucose metabolism 77 7.33e-02 -1.18e-01 2.64e-01
Pre-NOTCH Transcription and Translation 32 2.48e-01 -1.18e-01 5.42e-01
Degradation of beta-catenin by the destruction complex 76 7.58e-02 1.18e-01 2.68e-01
CRMPs in Sema3A signaling 15 4.30e-01 -1.18e-01 7.23e-01
Signaling by Retinoic Acid 33 2.44e-01 1.17e-01 5.40e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 4.64e-01 1.17e-01 7.51e-01
Reduction of cytosolic Ca++ levels 10 5.21e-01 -1.17e-01 7.82e-01
FOXO-mediated transcription of cell cycle genes 16 4.18e-01 -1.17e-01 7.19e-01
COPI-mediated anterograde transport 77 7.61e-02 -1.17e-01 2.68e-01
TRAF3-dependent IRF activation pathway 13 4.66e-01 1.17e-01 7.52e-01
G alpha (z) signalling events 39 2.07e-01 -1.17e-01 4.96e-01
Signaling by NOTCH1 66 1.02e-01 -1.17e-01 3.30e-01
Transport to the Golgi and subsequent modification 146 1.54e-02 -1.16e-01 9.35e-02
Sialic acid metabolism 25 3.15e-01 -1.16e-01 6.14e-01
Synthesis, secretion, and deacylation of Ghrelin 11 5.05e-01 1.16e-01 7.75e-01
rRNA processing in the mitochondrion 17 4.09e-01 1.16e-01 7.10e-01
MET activates RAP1 and RAC1 11 5.07e-01 1.15e-01 7.75e-01
Signaling by NOTCH3 44 1.87e-01 -1.15e-01 4.64e-01
Regulation of TP53 Expression and Degradation 33 2.53e-01 1.15e-01 5.49e-01
Signaling by FGFR3 in disease 16 4.28e-01 1.14e-01 7.23e-01
Signaling by FGFR3 point mutants in cancer 16 4.28e-01 1.14e-01 7.23e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 50 1.62e-01 1.14e-01 4.28e-01
The citric acid (TCA) cycle and respiratory electron transport 149 1.62e-02 1.14e-01 9.70e-02
Hedgehog ligand biogenesis 53 1.50e-01 1.14e-01 4.10e-01
eNOS activation 11 5.15e-01 1.13e-01 7.80e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 3.27e-01 1.13e-01 6.27e-01
Spry regulation of FGF signaling 14 4.63e-01 -1.13e-01 7.50e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.36e-01 1.13e-01 7.96e-01
Regulation of signaling by CBL 18 4.07e-01 1.13e-01 7.07e-01
Regulation of innate immune responses to cytosolic DNA 11 5.18e-01 1.13e-01 7.81e-01
Metabolism of carbohydrates 234 3.17e-03 -1.12e-01 2.94e-02
Cargo trafficking to the periciliary membrane 45 1.93e-01 1.12e-01 4.75e-01
Regulation of beta-cell development 22 3.63e-01 -1.12e-01 6.75e-01
Pyrimidine salvage 10 5.40e-01 1.12e-01 8.00e-01
Regulation of TP53 Activity through Association with Co-factors 12 5.02e-01 -1.12e-01 7.74e-01
ISG15 antiviral mechanism 62 1.30e-01 1.11e-01 3.85e-01
CTLA4 inhibitory signaling 21 3.77e-01 1.11e-01 6.89e-01
Ca-dependent events 35 2.55e-01 -1.11e-01 5.50e-01
Biotin transport and metabolism 11 5.23e-01 -1.11e-01 7.84e-01
Class I MHC mediated antigen processing & presentation 324 6.21e-04 1.11e-01 7.63e-03
Insulin receptor recycling 19 4.02e-01 -1.11e-01 7.06e-01
Regulation of HSF1-mediated heat shock response 70 1.12e-01 -1.10e-01 3.55e-01
Fc epsilon receptor (FCERI) signaling 121 3.73e-02 1.10e-01 1.69e-01
Signaling by KIT in disease 20 3.96e-01 1.10e-01 6.98e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 3.96e-01 1.10e-01 6.98e-01
Lewis blood group biosynthesis 11 5.29e-01 1.10e-01 7.89e-01
Signaling by BRAF and RAF fusions 56 1.57e-01 -1.09e-01 4.18e-01
Signaling by NTRKs 123 3.67e-02 -1.09e-01 1.68e-01
Formation of Incision Complex in GG-NER 40 2.32e-01 1.09e-01 5.24e-01
Retinoid metabolism and transport 27 3.28e-01 -1.09e-01 6.27e-01
Processing of Capped Intron-Containing Pre-mRNA 221 5.56e-03 1.09e-01 4.59e-02
RIPK1-mediated regulated necrosis 14 4.84e-01 1.08e-01 7.61e-01
Regulated Necrosis 14 4.84e-01 1.08e-01 7.61e-01
Asparagine N-linked glycosylation 249 3.41e-03 -1.08e-01 3.13e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 1.70e-01 -1.08e-01 4.39e-01
Transcriptional regulation by RUNX2 108 5.31e-02 1.08e-01 2.15e-01
Prefoldin mediated transfer of substrate to CCT/TriC 24 3.61e-01 1.08e-01 6.72e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 68 1.26e-01 -1.07e-01 3.79e-01
Oncogenic MAPK signaling 72 1.16e-01 -1.07e-01 3.61e-01
DNA Double Strand Break Response 39 2.47e-01 1.07e-01 5.42e-01
Transcriptional Regulation by VENTX 36 2.67e-01 -1.07e-01 5.58e-01
Keratan sulfate biosynthesis 21 3.99e-01 -1.06e-01 7.01e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 4.91e-01 1.06e-01 7.67e-01
Autophagy 116 4.87e-02 -1.06e-01 2.02e-01
Potential therapeutics for SARS 35 2.79e-01 1.06e-01 5.68e-01
Acyl chain remodelling of PG 11 5.44e-01 -1.06e-01 8.04e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 31 3.09e-01 -1.06e-01 6.06e-01
p75 NTR receptor-mediated signalling 85 9.35e-02 -1.05e-01 3.10e-01
FGFR2 alternative splicing 24 3.72e-01 -1.05e-01 6.85e-01
Negative regulation of MET activity 19 4.27e-01 -1.05e-01 7.23e-01
Muscle contraction 159 2.24e-02 -1.05e-01 1.22e-01
HDACs deacetylate histones 30 3.19e-01 1.05e-01 6.18e-01
Glycosaminoglycan metabolism 96 7.54e-02 -1.05e-01 2.68e-01
Acyl chain remodelling of PC 18 4.40e-01 1.05e-01 7.32e-01
tRNA processing in the mitochondrion 16 4.67e-01 1.05e-01 7.53e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 80 1.05e-01 1.05e-01 3.38e-01
Inositol phosphate metabolism 43 2.34e-01 -1.05e-01 5.25e-01
Neddylation 210 9.14e-03 1.05e-01 6.44e-02
Diseases of DNA repair 10 5.68e-01 -1.04e-01 8.21e-01
cGMP effects 13 5.15e-01 -1.04e-01 7.80e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.79e-01 -1.04e-01 5.68e-01
Receptor Mediated Mitophagy 11 5.49e-01 -1.04e-01 8.08e-01
RAS processing 20 4.21e-01 1.04e-01 7.21e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 38 2.68e-01 -1.04e-01 5.58e-01
HIV Transcription Elongation 38 2.68e-01 -1.04e-01 5.58e-01
Tat-mediated elongation of the HIV-1 transcript 38 2.68e-01 -1.04e-01 5.58e-01
ECM proteoglycans 42 2.44e-01 -1.04e-01 5.41e-01
Interleukin-7 signaling 20 4.22e-01 -1.04e-01 7.21e-01
Processing of SMDT1 15 4.89e-01 1.03e-01 7.65e-01
Interleukin-15 signaling 14 5.07e-01 1.02e-01 7.75e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 47 2.25e-01 -1.02e-01 5.14e-01
Sphingolipid metabolism 67 1.48e-01 -1.02e-01 4.09e-01
Protein-protein interactions at synapses 62 1.69e-01 -1.01e-01 4.37e-01
Glycolysis 59 1.80e-01 -1.01e-01 4.53e-01
Aggrephagy 17 4.72e-01 -1.01e-01 7.54e-01
Interleukin-37 signaling 18 4.61e-01 -1.00e-01 7.48e-01
MyD88 cascade initiated on plasma membrane 78 1.28e-01 -9.98e-02 3.82e-01
Toll Like Receptor 10 (TLR10) Cascade 78 1.28e-01 -9.98e-02 3.82e-01
Toll Like Receptor 5 (TLR5) Cascade 78 1.28e-01 -9.98e-02 3.82e-01
B-WICH complex positively regulates rRNA expression 32 3.32e-01 9.92e-02 6.32e-01
Glucagon signaling in metabolic regulation 27 3.74e-01 -9.89e-02 6.85e-01
O-linked glycosylation 70 1.54e-01 -9.87e-02 4.13e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 5.71e-01 9.87e-02 8.25e-01
Negative regulation of FGFR2 signaling 23 4.15e-01 -9.82e-02 7.18e-01
ER Quality Control Compartment (ERQC) 18 4.71e-01 -9.81e-02 7.54e-01
Diseases associated with glycosaminoglycan metabolism 35 3.16e-01 -9.80e-02 6.14e-01
Potassium Channels 64 1.77e-01 -9.76e-02 4.49e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 26 3.90e-01 9.75e-02 6.98e-01
Rap1 signalling 15 5.14e-01 -9.74e-02 7.80e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 3.91e-01 -9.72e-02 6.98e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 3.91e-01 -9.72e-02 6.98e-01
Vitamin B5 (pantothenate) metabolism 15 5.15e-01 9.72e-02 7.80e-01
TNFR2 non-canonical NF-kB pathway 75 1.46e-01 9.71e-02 4.07e-01
Neuronal System 262 7.18e-03 -9.68e-02 5.29e-02
ABC-family proteins mediated transport 86 1.23e-01 9.64e-02 3.74e-01
Infectious disease 574 9.46e-05 9.62e-02 1.53e-03
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 22 4.35e-01 -9.61e-02 7.27e-01
Cytochrome P450 - arranged by substrate type 33 3.41e-01 9.58e-02 6.45e-01
Maturation of nucleoprotein 10 6.01e-01 9.55e-02 8.43e-01
Regulation of TP53 Activity through Phosphorylation 87 1.25e-01 9.52e-02 3.78e-01
Synthesis of bile acids and bile salts 24 4.24e-01 9.42e-02 7.23e-01
Nucleobase catabolism 31 3.66e-01 9.40e-02 6.78e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 4.92e-01 9.36e-02 7.67e-01
Negative epigenetic regulation of rRNA expression 48 2.64e-01 9.32e-02 5.58e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 85 1.39e-01 -9.30e-02 3.99e-01
Amine ligand-binding receptors 13 5.62e-01 9.30e-02 8.16e-01
FRS-mediated FGFR2 signaling 16 5.20e-01 -9.29e-02 7.82e-01
GPVI-mediated activation cascade 30 3.80e-01 9.26e-02 6.93e-01
Hedgehog 'on' state 75 1.67e-01 9.24e-02 4.35e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 30 3.83e-01 -9.20e-02 6.94e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 4.09e-01 9.18e-02 7.10e-01
Fcgamma receptor (FCGR) dependent phagocytosis 86 1.42e-01 9.17e-02 4.00e-01
Integrin cell surface interactions 52 2.58e-01 -9.07e-02 5.54e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 12 5.87e-01 -9.07e-02 8.36e-01
Activation of G protein gated Potassium channels 21 4.75e-01 9.01e-02 7.55e-01
G protein gated Potassium channels 21 4.75e-01 9.01e-02 7.55e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 21 4.75e-01 9.01e-02 7.55e-01
Circadian Clock 63 2.17e-01 9.01e-02 5.05e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 39 3.31e-01 9.01e-02 6.31e-01
Interaction between L1 and Ankyrins 23 4.55e-01 -9.00e-02 7.45e-01
Activation of NMDA receptors and postsynaptic events 64 2.14e-01 -9.00e-02 5.03e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 52 2.62e-01 -8.99e-02 5.56e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 52 2.62e-01 -8.99e-02 5.56e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 52 2.62e-01 -8.99e-02 5.56e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 52 2.62e-01 -8.99e-02 5.56e-01
Signaling by NOTCH1 in Cancer 52 2.62e-01 -8.99e-02 5.56e-01
Nuclear Events (kinase and transcription factor activation) 56 2.45e-01 -8.99e-02 5.41e-01
Metabolism of nucleotides 87 1.48e-01 8.99e-02 4.09e-01
RUNX3 regulates NOTCH signaling 14 5.63e-01 -8.94e-02 8.16e-01
Antigen processing: Ubiquitination & Proteasome degradation 274 1.13e-02 8.93e-02 7.58e-02
Downstream signaling of activated FGFR1 22 4.70e-01 8.90e-02 7.54e-01
MTOR signalling 40 3.31e-01 -8.89e-02 6.31e-01
Sulfur amino acid metabolism 22 4.71e-01 8.87e-02 7.54e-01
Signaling by TGF-beta Receptor Complex 67 2.10e-01 8.87e-02 5.00e-01
rRNA modification in the nucleus and cytosol 53 2.65e-01 8.85e-02 5.58e-01
Synthesis of PIPs at the late endosome membrane 11 6.12e-01 8.84e-02 8.48e-01
Regulation of necroptotic cell death 12 5.97e-01 8.81e-02 8.40e-01
Bile acid and bile salt metabolism 27 4.30e-01 8.78e-02 7.23e-01
Nicotinate metabolism 25 4.49e-01 8.75e-02 7.40e-01
Long-term potentiation 18 5.22e-01 -8.73e-02 7.82e-01
Notch-HLH transcription pathway 25 4.51e-01 -8.71e-02 7.41e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 6.33e-01 -8.71e-02 8.65e-01
alpha-linolenic acid (ALA) metabolism 10 6.33e-01 -8.71e-02 8.65e-01
Cardiac conduction 100 1.33e-01 -8.71e-02 3.92e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 11 6.18e-01 -8.68e-02 8.51e-01
Transport of Mature Transcript to Cytoplasm 74 2.00e-01 8.63e-02 4.83e-01
Downregulation of TGF-beta receptor signaling 24 4.68e-01 8.56e-02 7.53e-01
Caspase activation via Death Receptors in the presence of ligand 15 5.66e-01 -8.56e-02 8.21e-01
Transcriptional regulation of pluripotent stem cells 16 5.54e-01 8.55e-02 8.11e-01
Carboxyterminal post-translational modifications of tubulin 26 4.51e-01 -8.54e-02 7.41e-01
Branched-chain amino acid catabolism 21 4.98e-01 8.54e-02 7.72e-01
Synthesis of substrates in N-glycan biosythesis 54 2.78e-01 -8.54e-02 5.68e-01
PI-3K cascade:FGFR3 12 6.09e-01 8.52e-02 8.48e-01
Late endosomal microautophagy 26 4.57e-01 -8.43e-02 7.47e-01
Signaling by GPCR 437 2.69e-03 -8.43e-02 2.58e-02
Disorders of transmembrane transporters 133 9.44e-02 8.42e-02 3.11e-01
Response of Mtb to phagocytosis 20 5.16e-01 8.40e-02 7.80e-01
Synthesis of IP2, IP, and Ins in the cytosol 14 5.87e-01 -8.38e-02 8.36e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 38 3.72e-01 8.38e-02 6.85e-01
Dopamine Neurotransmitter Release Cycle 16 5.62e-01 8.37e-02 8.16e-01
Transcriptional regulation of granulopoiesis 28 4.45e-01 8.35e-02 7.36e-01
Semaphorin interactions 63 2.55e-01 -8.30e-02 5.50e-01
p130Cas linkage to MAPK signaling for integrins 12 6.19e-01 8.28e-02 8.51e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 65 2.49e-01 8.28e-02 5.43e-01
Positive epigenetic regulation of rRNA expression 45 3.38e-01 8.26e-02 6.42e-01
MyD88 dependent cascade initiated on endosome 86 1.88e-01 -8.23e-02 4.64e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 86 1.88e-01 -8.23e-02 4.64e-01
Fatty acyl-CoA biosynthesis 24 4.88e-01 -8.19e-02 7.65e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 5.60e-01 8.17e-02 8.15e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 5.28e-01 8.16e-02 7.88e-01
Protein ubiquitination 56 2.92e-01 8.15e-02 5.82e-01
Signaling by ERBB2 43 3.56e-01 -8.15e-02 6.64e-01
TP53 Regulates Metabolic Genes 83 2.01e-01 -8.13e-02 4.86e-01
Metabolism of steroid hormones 18 5.52e-01 8.11e-02 8.10e-01
Formation of RNA Pol II elongation complex 53 3.10e-01 -8.06e-02 6.06e-01
RNA Polymerase II Transcription Elongation 53 3.10e-01 -8.06e-02 6.06e-01
Signaling by NOTCH2 27 4.69e-01 -8.06e-02 7.53e-01
C-type lectin receptors (CLRs) 110 1.45e-01 8.05e-02 4.07e-01
E3 ubiquitin ligases ubiquitinate target proteins 39 3.85e-01 8.04e-02 6.95e-01
Presynaptic function of Kainate receptors 17 5.71e-01 -7.94e-02 8.25e-01
The role of Nef in HIV-1 replication and disease pathogenesis 25 4.92e-01 7.94e-02 7.67e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 5.39e-01 7.93e-02 8.00e-01
Beta-catenin phosphorylation cascade 16 5.83e-01 -7.93e-02 8.35e-01
Signaling by Receptor Tyrosine Kinases 420 5.80e-03 -7.90e-02 4.68e-02
SUMOylation of transcription factors 15 5.96e-01 7.90e-02 8.40e-01
mRNA decay by 5' to 3' exoribonuclease 15 5.97e-01 7.88e-02 8.40e-01
Gene Silencing by RNA 61 2.89e-01 -7.85e-02 5.79e-01
EPH-ephrin mediated repulsion of cells 44 3.70e-01 -7.82e-02 6.83e-01
Protein localization 145 1.05e-01 7.82e-02 3.38e-01
Signaling by NTRK1 (TRKA) 107 1.64e-01 -7.80e-02 4.30e-01
Receptor-type tyrosine-protein phosphatases 14 6.14e-01 -7.79e-02 8.48e-01
Mitotic Prophase 77 2.39e-01 7.77e-02 5.32e-01
Suppression of phagosomal maturation 11 6.57e-01 -7.73e-02 8.84e-01
Negative regulation of FGFR4 signaling 20 5.50e-01 -7.73e-02 8.08e-01
Chaperone Mediated Autophagy 15 6.08e-01 -7.64e-02 8.48e-01
G alpha (s) signalling events 86 2.22e-01 -7.63e-02 5.12e-01
Formation of HIV elongation complex in the absence of HIV Tat 40 4.05e-01 -7.61e-02 7.07e-01
Oxidative Stress Induced Senescence 60 3.09e-01 -7.61e-02 6.06e-01
Toll Like Receptor 9 (TLR9) Cascade 89 2.16e-01 -7.60e-02 5.05e-01
Regulation of TNFR1 signaling 27 4.95e-01 7.58e-02 7.68e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 89 2.18e-01 -7.57e-02 5.05e-01
Toll Like Receptor 2 (TLR2) Cascade 89 2.18e-01 -7.57e-02 5.05e-01
Toll Like Receptor TLR1:TLR2 Cascade 89 2.18e-01 -7.57e-02 5.05e-01
Toll Like Receptor TLR6:TLR2 Cascade 89 2.18e-01 -7.57e-02 5.05e-01
Pyrimidine catabolism 10 6.80e-01 7.55e-02 8.88e-01
NOTCH1 Intracellular Domain Regulates Transcription 43 3.93e-01 -7.53e-02 6.98e-01
Beta-oxidation of very long chain fatty acids 10 6.82e-01 -7.49e-02 8.88e-01
CLEC7A (Dectin-1) signaling 89 2.23e-01 7.48e-02 5.12e-01
Neutrophil degranulation 360 1.60e-02 7.43e-02 9.63e-02
FOXO-mediated transcription of cell death genes 14 6.31e-01 7.42e-02 8.63e-01
Transmission across Chemical Synapses 173 9.33e-02 -7.42e-02 3.10e-01
Phospholipid metabolism 174 9.35e-02 -7.39e-02 3.10e-01
Plasma lipoprotein assembly, remodeling, and clearance 47 3.82e-01 -7.38e-02 6.94e-01
Activation of BH3-only proteins 27 5.08e-01 7.37e-02 7.75e-01
Interconversion of nucleotide di- and triphosphates 24 5.33e-01 7.35e-02 7.94e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 39 4.30e-01 -7.31e-02 7.23e-01
Signaling by RAS mutants 39 4.30e-01 -7.31e-02 7.23e-01
Signaling by moderate kinase activity BRAF mutants 39 4.30e-01 -7.31e-02 7.23e-01
Signaling downstream of RAS mutants 39 4.30e-01 -7.31e-02 7.23e-01
G-protein activation 19 5.82e-01 -7.29e-02 8.35e-01
Pausing and recovery of Tat-mediated HIV elongation 26 5.20e-01 -7.29e-02 7.82e-01
Tat-mediated HIV elongation arrest and recovery 26 5.20e-01 -7.29e-02 7.82e-01
Association of TriC/CCT with target proteins during biosynthesis 36 4.50e-01 7.28e-02 7.41e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 5.25e-01 -7.20e-02 7.86e-01
GPCR downstream signalling 404 1.40e-02 -7.17e-02 8.69e-02
Mitophagy 25 5.36e-01 -7.15e-02 7.96e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 6.81e-01 -7.15e-02 8.88e-01
SARS-CoV-1 Infection 43 4.18e-01 -7.14e-02 7.19e-01
Interactions of Rev with host cellular proteins 31 4.92e-01 7.13e-02 7.67e-01
Metabolism of non-coding RNA 48 3.94e-01 7.12e-02 6.98e-01
snRNP Assembly 48 3.94e-01 7.12e-02 6.98e-01
Nuclear Pore Complex (NPC) Disassembly 31 4.94e-01 7.10e-02 7.67e-01
Signaling by WNT 228 6.82e-02 -7.04e-02 2.51e-01
Cell-Cell communication 82 2.75e-01 -6.98e-02 5.64e-01
COPI-independent Golgi-to-ER retrograde traffic 30 5.09e-01 -6.97e-02 7.75e-01
Transcriptional Regulation by MECP2 46 4.17e-01 -6.92e-02 7.19e-01
Fatty acid metabolism 134 1.68e-01 6.91e-02 4.37e-01
TCF dependent signaling in response to WNT 147 1.49e-01 -6.91e-02 4.10e-01
RUNX2 regulates bone development 28 5.28e-01 -6.90e-02 7.88e-01
SLBP independent Processing of Histone Pre-mRNAs 10 7.06e-01 -6.88e-02 9.04e-01
Metabolism of fat-soluble vitamins 31 5.09e-01 -6.86e-02 7.75e-01
Detoxification of Reactive Oxygen Species 30 5.17e-01 6.83e-02 7.81e-01
Assembly and cell surface presentation of NMDA receptors 17 6.26e-01 -6.82e-02 8.59e-01
Growth hormone receptor signaling 19 6.07e-01 -6.82e-02 8.47e-01
Glutamate Neurotransmitter Release Cycle 17 6.28e-01 -6.80e-02 8.60e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 6.84e-01 6.78e-02 8.88e-01
ADP signalling through P2Y purinoceptor 1 21 5.91e-01 -6.77e-02 8.39e-01
Signaling by FGFR2 58 3.74e-01 -6.76e-02 6.85e-01
MyD88-independent TLR4 cascade 91 2.66e-01 -6.76e-02 5.58e-01
TRIF(TICAM1)-mediated TLR4 signaling 91 2.66e-01 -6.76e-02 5.58e-01
Nephrin family interactions 19 6.12e-01 6.73e-02 8.48e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 6.43e-01 6.69e-02 8.75e-01
G alpha (q) signalling events 126 1.96e-01 -6.68e-02 4.78e-01
Glutamate and glutamine metabolism 12 6.89e-01 -6.67e-02 8.89e-01
Interleukin receptor SHC signaling 21 5.98e-01 6.66e-02 8.40e-01
Amino acids regulate mTORC1 48 4.26e-01 -6.65e-02 7.23e-01
NS1 Mediated Effects on Host Pathways 33 5.12e-01 6.60e-02 7.79e-01
Erythropoietin activates RAS 13 6.81e-01 6.58e-02 8.88e-01
Retrograde transport at the Trans-Golgi-Network 45 4.48e-01 -6.54e-02 7.40e-01
HIV Infection 205 1.08e-01 6.53e-02 3.44e-01
TBC/RABGAPs 40 4.76e-01 -6.51e-02 7.56e-01
NOD1/2 Signaling Pathway 29 5.45e-01 -6.49e-02 8.04e-01
Intraflagellar transport 36 5.02e-01 6.47e-02 7.74e-01
Purine catabolism 17 6.45e-01 6.46e-02 8.76e-01
Surfactant metabolism 14 6.77e-01 -6.43e-02 8.88e-01
NOTCH3 Intracellular Domain Regulates Transcription 23 5.94e-01 -6.42e-02 8.40e-01
Cellular responses to external stimuli 429 2.39e-02 6.40e-02 1.28e-01
RNA Polymerase III Transcription Termination 23 5.96e-01 6.40e-02 8.40e-01
RHO GTPases Activate ROCKs 19 6.30e-01 -6.39e-02 8.62e-01
ABC transporters in lipid homeostasis 14 6.79e-01 6.38e-02 8.88e-01
TGF-beta receptor signaling activates SMADs 29 5.53e-01 6.37e-02 8.11e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 11 7.16e-01 -6.35e-02 9.10e-01
CASP8 activity is inhibited 10 7.29e-01 6.33e-02 9.18e-01
Dimerization of procaspase-8 10 7.29e-01 6.33e-02 9.18e-01
Regulation by c-FLIP 10 7.29e-01 6.33e-02 9.18e-01
Innate Immune System 759 3.39e-03 6.33e-02 3.13e-02
FCERI mediated MAPK activation 30 5.50e-01 6.31e-02 8.08e-01
Inhibition of DNA recombination at telomere 20 6.26e-01 6.30e-02 8.59e-01
FRS-mediated FGFR1 signaling 14 6.84e-01 6.29e-02 8.88e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 6.03e-01 -6.27e-02 8.44e-01
Signaling by FGFR2 in disease 33 5.35e-01 -6.25e-02 7.96e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 6.75e-01 6.24e-02 8.88e-01
SUMOylation of DNA methylation proteins 16 6.66e-01 -6.24e-02 8.88e-01
DNA Damage/Telomere Stress Induced Senescence 26 5.84e-01 6.20e-02 8.35e-01
Cellular responses to stress 424 2.95e-02 6.20e-02 1.48e-01
Synthesis of PIPs at the plasma membrane 51 4.44e-01 6.20e-02 7.36e-01
Regulation of RUNX1 Expression and Activity 17 6.58e-01 -6.20e-02 8.85e-01
Postmitotic nuclear pore complex (NPC) reformation 25 5.92e-01 6.19e-02 8.39e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 6.68e-01 6.19e-02 8.88e-01
Metabolism of water-soluble vitamins and cofactors 104 2.77e-01 -6.18e-02 5.67e-01
Regulation of MECP2 expression and activity 28 5.73e-01 -6.15e-02 8.27e-01
Complex I biogenesis 54 4.35e-01 6.15e-02 7.27e-01
Hyaluronan metabolism 14 6.91e-01 6.14e-02 8.89e-01
PINK1-PRKN Mediated Mitophagy 18 6.52e-01 -6.14e-02 8.80e-01
LDL clearance 15 6.84e-01 -6.08e-02 8.88e-01
Other interleukin signaling 19 6.48e-01 6.06e-02 8.79e-01
Epigenetic regulation of gene expression 84 3.42e-01 6.01e-02 6.45e-01
N-Glycan antennae elongation 13 7.09e-01 5.98e-02 9.05e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.91e-01 -5.97e-02 8.39e-01
Downregulation of ERBB2:ERBB3 signaling 11 7.32e-01 -5.96e-02 9.19e-01
FRS-mediated FGFR4 signaling 13 7.10e-01 -5.96e-02 9.05e-01
Toll Like Receptor 4 (TLR4) Cascade 117 2.69e-01 -5.93e-02 5.58e-01
Sphingolipid de novo biosynthesis 33 5.57e-01 -5.91e-02 8.13e-01
Transport of the SLBP independent Mature mRNA 30 5.76e-01 -5.90e-02 8.30e-01
Neurotransmitter receptors and postsynaptic signal transmission 130 2.47e-01 -5.89e-02 5.42e-01
Keratinization 24 6.18e-01 5.88e-02 8.51e-01
Signaling by Interleukins 351 6.18e-02 5.84e-02 2.37e-01
Beta-catenin independent WNT signaling 131 2.51e-01 -5.82e-02 5.46e-01
Immune System 1550 1.93e-04 5.82e-02 2.75e-03
RMTs methylate histone arginines 29 5.89e-01 -5.80e-02 8.38e-01
NoRC negatively regulates rRNA expression 45 5.08e-01 5.71e-02 7.75e-01
Signalling to RAS 19 6.68e-01 5.69e-02 8.88e-01
Metabolism of vitamins and cofactors 153 2.31e-01 -5.62e-02 5.23e-01
HCMV Early Events 53 4.81e-01 5.60e-02 7.60e-01
Signalling to ERKs 32 5.83e-01 5.60e-02 8.35e-01
Signal Transduction 1761 1.50e-04 -5.60e-02 2.16e-03
RNA Polymerase I Transcription Termination 30 5.97e-01 -5.58e-02 8.40e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 6.91e-01 -5.58e-02 8.89e-01
Repression of WNT target genes 12 7.39e-01 -5.55e-02 9.23e-01
Crosslinking of collagen fibrils 10 7.62e-01 -5.53e-02 9.23e-01
Cell recruitment (pro-inflammatory response) 19 6.80e-01 -5.47e-02 8.88e-01
Purinergic signaling in leishmaniasis infection 19 6.80e-01 -5.47e-02 8.88e-01
Class A/1 (Rhodopsin-like receptors) 125 2.96e-01 5.43e-02 5.86e-01
PKA-mediated phosphorylation of CREB 19 6.84e-01 -5.40e-02 8.88e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 7.57e-01 -5.38e-02 9.23e-01
RUNX2 regulates osteoblast differentiation 22 6.63e-01 -5.37e-02 8.88e-01
SLC-mediated transmembrane transport 165 2.36e-01 5.37e-02 5.28e-01
Triglyceride metabolism 23 6.56e-01 -5.36e-02 8.84e-01
RNA polymerase II transcribes snRNA genes 70 4.40e-01 -5.35e-02 7.32e-01
Rev-mediated nuclear export of HIV RNA 30 6.13e-01 5.34e-02 8.48e-01
Mitochondrial translation 91 3.83e-01 -5.30e-02 6.94e-01
Transcriptional regulation by RUNX1 155 2.56e-01 5.29e-02 5.51e-01
Tight junction interactions 11 7.62e-01 5.28e-02 9.23e-01
Apoptotic cleavage of cellular proteins 33 6.00e-01 -5.28e-02 8.42e-01
IKK complex recruitment mediated by RIP1 19 6.93e-01 -5.23e-02 8.89e-01
IRAK4 deficiency (TLR2/4) 11 7.64e-01 -5.22e-02 9.23e-01
MHC class II antigen presentation 90 3.95e-01 5.19e-02 6.98e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 6.18e-01 5.18e-02 8.51e-01
Inwardly rectifying K+ channels 26 6.50e-01 5.15e-02 8.80e-01
Ovarian tumor domain proteases 34 6.04e-01 5.15e-02 8.45e-01
Signal transduction by L1 21 6.85e-01 5.11e-02 8.88e-01
Adenylate cyclase inhibitory pathway 14 7.41e-01 -5.11e-02 9.23e-01
Glyoxylate metabolism and glycine degradation 24 6.66e-01 -5.09e-02 8.88e-01
Regulation of TP53 Activity 148 2.90e-01 5.05e-02 5.79e-01
Cell surface interactions at the vascular wall 96 3.95e-01 5.03e-02 6.98e-01
Interleukin-20 family signaling 15 7.38e-01 -4.98e-02 9.23e-01
Nuclear signaling by ERBB4 27 6.55e-01 -4.97e-02 8.84e-01
MET receptor recycling 10 7.88e-01 -4.92e-02 9.35e-01
Signaling by NTRK3 (TRKC) 17 7.26e-01 -4.91e-02 9.18e-01
Interleukin-17 signaling 63 5.03e-01 -4.88e-02 7.74e-01
Calnexin/calreticulin cycle 23 6.87e-01 -4.86e-02 8.88e-01
Generic Transcription Pathway 868 1.72e-02 4.83e-02 9.99e-02
L1CAM interactions 88 4.35e-01 -4.82e-02 7.27e-01
RNA Polymerase II Transcription 982 1.22e-02 4.80e-02 8.03e-02
Transcriptional regulation by RUNX3 89 4.35e-01 4.79e-02 7.27e-01
Class I peroxisomal membrane protein import 19 7.18e-01 4.78e-02 9.12e-01
Plasma lipoprotein clearance 24 6.87e-01 -4.76e-02 8.88e-01
Cargo recognition for clathrin-mediated endocytosis 85 4.49e-01 -4.76e-02 7.40e-01
Vesicle-mediated transport 568 5.52e-02 -4.75e-02 2.19e-01
Oncogene Induced Senescence 29 6.59e-01 -4.73e-02 8.85e-01
Negative regulation of MAPK pathway 40 6.05e-01 -4.73e-02 8.45e-01
Diseases of signal transduction by growth factor receptors and second messengers 336 1.39e-01 -4.72e-02 3.99e-01
Metabolism of proteins 1573 2.45e-03 4.70e-02 2.39e-02
Estrogen-dependent gene expression 83 4.60e-01 -4.70e-02 7.48e-01
VEGFA-VEGFR2 Pathway 90 4.45e-01 4.67e-02 7.36e-01
Cytokine Signaling in Immune system 662 4.31e-02 4.66e-02 1.86e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 26 6.82e-01 -4.65e-02 8.88e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 26 6.82e-01 -4.65e-02 8.88e-01
Misspliced GSK3beta mutants stabilize beta-catenin 14 7.64e-01 -4.65e-02 9.23e-01
S33 mutants of beta-catenin aren't phosphorylated 14 7.64e-01 -4.65e-02 9.23e-01
S37 mutants of beta-catenin aren't phosphorylated 14 7.64e-01 -4.65e-02 9.23e-01
S45 mutants of beta-catenin aren't phosphorylated 14 7.64e-01 -4.65e-02 9.23e-01
T41 mutants of beta-catenin aren't phosphorylated 14 7.64e-01 -4.65e-02 9.23e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 7.64e-01 -4.65e-02 9.23e-01
SHC-mediated cascade:FGFR4 11 7.91e-01 4.62e-02 9.35e-01
NRIF signals cell death from the nucleus 14 7.67e-01 4.58e-02 9.23e-01
MAPK6/MAPK4 signaling 79 4.83e-01 4.57e-02 7.61e-01
Tie2 Signaling 16 7.53e-01 4.55e-02 9.23e-01
Post-translational modification: synthesis of GPI-anchored proteins 60 5.45e-01 -4.53e-02 8.04e-01
G beta:gamma signalling through CDC42 16 7.56e-01 -4.50e-02 9.23e-01
PI-3K cascade:FGFR2 14 7.71e-01 -4.50e-02 9.24e-01
tRNA processing in the nucleus 52 5.75e-01 -4.50e-02 8.29e-01
NEP/NS2 Interacts with the Cellular Export Machinery 27 6.88e-01 4.47e-02 8.88e-01
AURKA Activation by TPX2 71 5.16e-01 4.46e-02 7.80e-01
Mitochondrial translation initiation 85 4.78e-01 -4.46e-02 7.57e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 31 6.69e-01 -4.44e-02 8.88e-01
COPI-dependent Golgi-to-ER retrograde traffic 76 5.04e-01 4.44e-02 7.75e-01
Regulation of PTEN gene transcription 59 5.58e-01 -4.42e-02 8.13e-01
DNA Damage Recognition in GG-NER 35 6.52e-01 4.41e-02 8.80e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.87e-01 4.41e-02 8.88e-01
Adrenaline,noradrenaline inhibits insulin secretion 22 7.22e-01 -4.38e-02 9.14e-01
Transcriptional Regulation by TP53 333 1.74e-01 4.36e-02 4.44e-01
Toll Like Receptor 3 (TLR3) Cascade 87 4.84e-01 -4.35e-02 7.61e-01
Cleavage of the damaged purine 11 8.03e-01 4.35e-02 9.36e-01
Depurination 11 8.03e-01 4.35e-02 9.36e-01
Recognition and association of DNA glycosylase with site containing an affected purine 11 8.03e-01 4.35e-02 9.36e-01
PI Metabolism 79 5.06e-01 4.33e-02 7.75e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.13e-01 4.32e-02 9.40e-01
G alpha (i) signalling events 208 2.84e-01 -4.32e-02 5.72e-01
Formation of the cornified envelope 18 7.52e-01 -4.31e-02 9.23e-01
RNA Polymerase I Promoter Escape 30 6.84e-01 -4.30e-02 8.88e-01
Cellular Senescence 118 4.21e-01 -4.30e-02 7.21e-01
PCP/CE pathway 85 4.95e-01 -4.28e-02 7.68e-01
Gene expression (Transcription) 1100 1.94e-02 4.25e-02 1.11e-01
TNFR1-induced proapoptotic signaling 13 7.91e-01 -4.25e-02 9.35e-01
ERK/MAPK targets 22 7.31e-01 4.24e-02 9.18e-01
Downstream signaling of activated FGFR3 19 7.50e-01 4.22e-02 9.23e-01
Mitochondrial translation elongation 85 5.02e-01 -4.22e-02 7.74e-01
SHC1 events in ERBB4 signaling 12 8.01e-01 4.21e-02 9.36e-01
Formation of TC-NER Pre-Incision Complex 50 6.08e-01 4.20e-02 8.47e-01
Regulation of localization of FOXO transcription factors 12 8.04e-01 4.14e-02 9.36e-01
ADORA2B mediated anti-inflammatory cytokines production 62 5.78e-01 -4.09e-02 8.31e-01
Hedgehog 'off' state 91 5.01e-01 4.08e-02 7.74e-01
Viral Messenger RNA Synthesis 38 6.64e-01 -4.07e-02 8.88e-01
Signaling by PDGFR in disease 20 7.53e-01 4.07e-02 9.23e-01
RNA Polymerase II Pre-transcription Events 75 5.44e-01 -4.06e-02 8.04e-01
ADP signalling through P2Y purinoceptor 12 18 7.66e-01 4.06e-02 9.23e-01
Downstream signaling of activated FGFR2 21 7.48e-01 -4.06e-02 9.23e-01
Signaling by NODAL 13 8.05e-01 -3.96e-02 9.36e-01
TNFs bind their physiological receptors 11 8.21e-01 -3.94e-02 9.44e-01
HCMV Infection 74 5.59e-01 3.93e-02 8.15e-01
TNF signaling 37 6.85e-01 3.86e-02 8.88e-01
TP53 Regulates Transcription of Cell Death Genes 36 6.90e-01 3.84e-02 8.89e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 7.62e-01 3.81e-02 9.23e-01
Mitochondrial calcium ion transport 20 7.68e-01 3.81e-02 9.23e-01
G beta:gamma signalling through BTK 14 8.07e-01 -3.77e-02 9.37e-01
Membrane Trafficking 538 1.39e-01 -3.76e-02 3.99e-01
GABA receptor activation 40 6.81e-01 3.76e-02 8.88e-01
Post-translational protein modification 1124 3.70e-02 3.76e-02 1.68e-01
Synthesis of pyrophosphates in the cytosol 10 8.37e-01 -3.75e-02 9.49e-01
Death Receptor Signalling 123 4.74e-01 -3.75e-02 7.55e-01
Golgi Associated Vesicle Biogenesis 52 6.45e-01 -3.70e-02 8.76e-01
Transport of the SLBP Dependant Mature mRNA 31 7.22e-01 -3.70e-02 9.14e-01
RORA activates gene expression 17 7.92e-01 -3.69e-02 9.35e-01
Signaling by FGFR1 in disease 31 7.22e-01 3.69e-02 9.14e-01
FGFR1 mutant receptor activation 24 7.59e-01 3.62e-02 9.23e-01
Signaling by NOTCH 160 4.30e-01 -3.62e-02 7.23e-01
Molecules associated with elastic fibres 28 7.41e-01 -3.61e-02 9.23e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 7.81e-01 3.58e-02 9.33e-01
Metabolism 1629 1.97e-02 3.56e-02 1.12e-01
RHO GTPases activate CIT 19 7.90e-01 3.54e-02 9.35e-01
HIV elongation arrest and recovery 28 7.46e-01 -3.53e-02 9.23e-01
Pausing and recovery of HIV elongation 28 7.46e-01 -3.53e-02 9.23e-01
Fanconi Anemia Pathway 31 7.35e-01 3.52e-02 9.21e-01
Platelet Aggregation (Plug Formation) 25 7.61e-01 3.52e-02 9.23e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 56 6.52e-01 -3.49e-02 8.80e-01
MAPK family signaling cascades 272 3.24e-01 -3.49e-02 6.24e-01
Toll-like Receptor Cascades 133 4.93e-01 -3.45e-02 7.67e-01
Nuclear Receptor transcription pathway 44 6.93e-01 3.44e-02 8.89e-01
Activation of the AP-1 family of transcription factors 10 8.51e-01 3.44e-02 9.56e-01
Recycling pathway of L1 27 7.58e-01 -3.43e-02 9.23e-01
TRP channels 12 8.37e-01 3.42e-02 9.49e-01
Signaling by Insulin receptor 59 6.51e-01 -3.41e-02 8.80e-01
MyD88 deficiency (TLR2/4) 10 8.53e-01 -3.39e-02 9.56e-01
ERKs are inactivated 13 8.33e-01 3.38e-02 9.49e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 13 8.33e-01 -3.38e-02 9.49e-01
Activation of GABAB receptors 35 7.30e-01 3.37e-02 9.18e-01
GABA B receptor activation 35 7.30e-01 3.37e-02 9.18e-01
Cytosolic sensors of pathogen-associated DNA 57 6.61e-01 -3.36e-02 8.87e-01
Downstream signal transduction 28 7.59e-01 -3.35e-02 9.23e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.06e-01 -3.34e-02 9.37e-01
CaMK IV-mediated phosphorylation of CREB 10 8.55e-01 3.34e-02 9.56e-01
VEGFR2 mediated cell proliferation 19 8.02e-01 -3.32e-02 9.36e-01
Regulation of TP53 Activity through Acetylation 29 7.57e-01 -3.32e-02 9.23e-01
CD209 (DC-SIGN) signaling 19 8.03e-01 -3.30e-02 9.36e-01
Metabolism of porphyrins 22 7.90e-01 -3.28e-02 9.35e-01
Metabolism of steroids 111 5.53e-01 -3.26e-02 8.11e-01
Signaling by Rho GTPases 339 3.09e-01 3.23e-02 6.06e-01
Activation of kainate receptors upon glutamate binding 24 7.86e-01 -3.21e-02 9.35e-01
Platelet sensitization by LDL 15 8.30e-01 -3.20e-02 9.48e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 18 8.14e-01 3.20e-02 9.40e-01
AKT phosphorylates targets in the cytosol 14 8.38e-01 -3.15e-02 9.49e-01
Transport of vitamins, nucleosides, and related molecules 29 7.70e-01 -3.13e-02 9.24e-01
MAP2K and MAPK activation 34 7.55e-01 -3.10e-02 9.23e-01
Purine ribonucleoside monophosphate biosynthesis 12 8.53e-01 3.08e-02 9.56e-01
PPARA activates gene expression 110 5.78e-01 3.08e-02 8.31e-01
Blood group systems biosynthesis 13 8.52e-01 -2.98e-02 9.56e-01
Mitochondrial translation termination 85 6.37e-01 -2.97e-02 8.67e-01
Regulation of lipid metabolism by PPARalpha 112 5.93e-01 2.93e-02 8.39e-01
Base-Excision Repair, AP Site Formation 18 8.31e-01 -2.90e-02 9.48e-01
G beta:gamma signalling through PI3Kgamma 21 8.18e-01 2.90e-02 9.44e-01
Negative regulation of FGFR3 signaling 21 8.19e-01 -2.88e-02 9.44e-01
Triglyceride catabolism 15 8.48e-01 2.87e-02 9.55e-01
Nuclear import of Rev protein 28 7.94e-01 2.85e-02 9.35e-01
Transport of small molecules 506 2.90e-01 -2.77e-02 5.79e-01
Metabolism of cofactors 19 8.35e-01 2.77e-02 9.49e-01
RHO GTPases activate PAKs 21 8.27e-01 2.76e-02 9.48e-01
HIV Transcription Initiation 45 7.49e-01 -2.76e-02 9.23e-01
RNA Polymerase II HIV Promoter Escape 45 7.49e-01 -2.76e-02 9.23e-01
RNA Polymerase II Promoter Escape 45 7.49e-01 -2.76e-02 9.23e-01
RNA Polymerase II Transcription Initiation 45 7.49e-01 -2.76e-02 9.23e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 7.49e-01 -2.76e-02 9.23e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 7.49e-01 -2.76e-02 9.23e-01
Fertilization 10 8.80e-01 -2.75e-02 9.70e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 75 6.83e-01 -2.73e-02 8.88e-01
Signaling by MET 61 7.14e-01 2.72e-02 9.10e-01
Mitochondrial protein import 59 7.21e-01 2.69e-02 9.14e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 20 8.35e-01 2.69e-02 9.49e-01
Nuclear Envelope (NE) Reassembly 65 7.10e-01 2.67e-02 9.05e-01
ESR-mediated signaling 144 5.82e-01 -2.66e-02 8.35e-01
FLT3 Signaling 246 4.75e-01 -2.65e-02 7.55e-01
mTORC1-mediated signalling 23 8.26e-01 2.65e-02 9.48e-01
trans-Golgi Network Vesicle Budding 67 7.08e-01 -2.65e-02 9.05e-01
Cilium Assembly 171 5.55e-01 2.62e-02 8.11e-01
Signaling by FGFR in disease 52 7.45e-01 -2.61e-02 9.23e-01
Regulation of PLK1 Activity at G2/M Transition 84 6.80e-01 2.61e-02 8.88e-01
Synthesis of PIPs at the Golgi membrane 15 8.62e-01 -2.59e-02 9.61e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 8.84e-01 -2.54e-02 9.70e-01
Signaling by Non-Receptor Tyrosine Kinases 49 7.58e-01 -2.54e-02 9.23e-01
Signaling by PTK6 49 7.58e-01 -2.54e-02 9.23e-01
Budding and maturation of HIV virion 24 8.30e-01 -2.54e-02 9.48e-01
Interleukin-2 signaling 11 8.85e-01 2.52e-02 9.70e-01
Prostacyclin signalling through prostacyclin receptor 15 8.67e-01 -2.49e-02 9.63e-01
Signaling by FGFR1 38 7.94e-01 2.45e-02 9.35e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 16 8.65e-01 -2.45e-02 9.62e-01
Intracellular signaling by second messengers 276 4.87e-01 -2.44e-02 7.65e-01
Formation of tubulin folding intermediates by CCT/TriC 19 8.54e-01 2.44e-02 9.56e-01
Striated Muscle Contraction 29 8.21e-01 -2.43e-02 9.44e-01
Anti-inflammatory response favouring Leishmania parasite infection 97 6.80e-01 -2.43e-02 8.88e-01
Leishmania parasite growth and survival 97 6.80e-01 -2.43e-02 8.88e-01
Apoptosis 149 6.11e-01 2.42e-02 8.48e-01
Interleukin-1 signaling 90 6.92e-01 2.42e-02 8.89e-01
Netrin-1 signaling 42 7.87e-01 -2.42e-02 9.35e-01
TICAM1, RIP1-mediated IKK complex recruitment 16 8.68e-01 2.40e-02 9.63e-01
SLC transporter disorders 70 7.30e-01 2.39e-02 9.18e-01
Programmed Cell Death 152 6.12e-01 2.39e-02 8.48e-01
RNA Polymerase I Transcription Initiation 45 7.84e-01 -2.36e-02 9.35e-01
Transport of Mature mRNA Derived from an Intronless Transcript 37 8.04e-01 -2.36e-02 9.36e-01
IGF1R signaling cascade 40 7.97e-01 2.35e-02 9.36e-01
Nuclear Envelope Breakdown 48 7.80e-01 2.34e-02 9.32e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 38 8.04e-01 -2.33e-02 9.36e-01
Metabolic disorders of biological oxidation enzymes 20 8.58e-01 2.32e-02 9.58e-01
Constitutive Signaling by Overexpressed ERBB2 10 8.99e-01 -2.31e-02 9.73e-01
RAB GEFs exchange GTP for GDP on RABs 84 7.16e-01 2.30e-02 9.10e-01
Signaling by NTRK2 (TRKB) 22 8.54e-01 -2.26e-02 9.56e-01
GPCR ligand binding 173 6.12e-01 -2.24e-02 8.48e-01
Cell-cell junction organization 27 8.41e-01 -2.23e-02 9.51e-01
Basigin interactions 20 8.63e-01 -2.23e-02 9.61e-01
Transcriptional regulation by small RNAs 42 8.04e-01 -2.21e-02 9.36e-01
FOXO-mediated transcription 55 7.78e-01 -2.20e-02 9.32e-01
SUMOylation of chromatin organization proteins 49 7.92e-01 2.17e-02 9.35e-01
Synthesis of PIPs at the early endosome membrane 16 8.81e-01 2.16e-02 9.70e-01
Platelet activation, signaling and aggregation 212 5.90e-01 -2.16e-02 8.38e-01
RNA Polymerase III Abortive And Retractive Initiation 41 8.13e-01 2.14e-02 9.40e-01
RNA Polymerase III Transcription 41 8.13e-01 2.14e-02 9.40e-01
TICAM1-dependent activation of IRF3/IRF7 10 9.07e-01 2.13e-02 9.73e-01
PTEN Regulation 132 6.73e-01 2.13e-02 8.88e-01
RHO GTPases activate PKNs 32 8.35e-01 -2.12e-02 9.49e-01
SUMOylation of transcription cofactors 39 8.19e-01 2.12e-02 9.44e-01
Transcription of the HIV genome 64 7.70e-01 -2.11e-02 9.24e-01
Signaling by FGFR4 30 8.41e-01 -2.11e-02 9.51e-01
Opioid Signalling 78 7.48e-01 -2.11e-02 9.23e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 8.88e-01 -2.10e-02 9.71e-01
Gap junction trafficking 14 8.92e-01 -2.09e-02 9.71e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 35 8.30e-01 2.09e-02 9.48e-01
Signaling by ERBB4 45 8.09e-01 -2.09e-02 9.38e-01
MAP kinase activation 60 7.80e-01 -2.09e-02 9.32e-01
Late Phase of HIV Life Cycle 121 6.96e-01 -2.06e-02 8.92e-01
mRNA Splicing - Minor Pathway 48 8.07e-01 -2.04e-02 9.37e-01
Transcriptional regulation of white adipocyte differentiation 77 7.58e-01 2.03e-02 9.23e-01
SUMOylation of SUMOylation proteins 29 8.51e-01 2.02e-02 9.56e-01
Signal regulatory protein family interactions 13 9.00e-01 2.01e-02 9.73e-01
Metabolism of lipids 578 4.17e-01 -2.00e-02 7.19e-01
PI3K Cascade 32 8.47e-01 -1.98e-02 9.55e-01
SUMOylation of immune response proteins 11 9.10e-01 -1.97e-02 9.73e-01
SARS-CoV Infections 77 7.65e-01 1.97e-02 9.23e-01
Phase 0 - rapid depolarisation 33 8.46e-01 -1.95e-02 9.55e-01
Serotonin Neurotransmitter Release Cycle 11 9.12e-01 -1.93e-02 9.74e-01
Depolymerisation of the Nuclear Lamina 15 8.98e-01 1.92e-02 9.73e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 19 8.86e-01 -1.91e-02 9.70e-01
Neurodegenerative Diseases 19 8.86e-01 -1.91e-02 9.70e-01
PKMTs methylate histone lysines 37 8.41e-01 1.91e-02 9.51e-01
Diseases of programmed cell death 20 8.83e-01 -1.89e-02 9.70e-01
Signaling by TGFB family members 87 7.68e-01 1.84e-02 9.23e-01
Acyl chain remodelling of PS 14 9.06e-01 1.82e-02 9.73e-01
VxPx cargo-targeting to cilium 18 8.94e-01 -1.81e-02 9.72e-01
Organelle biogenesis and maintenance 241 6.34e-01 1.79e-02 8.65e-01
O-linked glycosylation of mucins 33 8.62e-01 -1.75e-02 9.61e-01
Chromatin modifying enzymes 186 6.88e-01 -1.71e-02 8.88e-01
Chromatin organization 186 6.88e-01 -1.71e-02 8.88e-01
TP53 Regulates Transcription of DNA Repair Genes 57 8.23e-01 1.71e-02 9.46e-01
Signaling by SCF-KIT 42 8.50e-01 1.69e-02 9.56e-01
Cleavage of the damaged pyrimidine 16 9.07e-01 1.69e-02 9.73e-01
Depyrimidination 16 9.07e-01 1.69e-02 9.73e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 9.07e-01 1.69e-02 9.73e-01
Chaperonin-mediated protein folding 81 7.96e-01 1.66e-02 9.36e-01
RAF/MAP kinase cascade 232 6.64e-01 -1.66e-02 8.88e-01
tRNA modification in the nucleus and cytosol 38 8.60e-01 1.65e-02 9.60e-01
RAF-independent MAPK1/3 activation 21 8.97e-01 1.64e-02 9.73e-01
Signal amplification 29 8.79e-01 -1.63e-02 9.70e-01
Platelet degranulation 102 7.80e-01 1.60e-02 9.32e-01
Signaling by RAF1 mutants 35 8.72e-01 -1.58e-02 9.65e-01
Frs2-mediated activation 12 9.25e-01 -1.56e-02 9.80e-01
Cargo concentration in the ER 23 8.98e-01 -1.55e-02 9.73e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 8.91e-01 1.53e-02 9.71e-01
Factors involved in megakaryocyte development and platelet production 104 7.89e-01 1.52e-02 9.35e-01
Hemostasis 453 5.85e-01 -1.51e-02 8.35e-01
TNFR1-induced NFkappaB signaling pathway 24 8.99e-01 1.49e-02 9.73e-01
Signaling by VEGF 98 8.02e-01 1.47e-02 9.36e-01
Rab regulation of trafficking 114 7.87e-01 -1.47e-02 9.35e-01
SHC-mediated cascade:FGFR2 14 9.25e-01 -1.46e-02 9.80e-01
Lysosome Vesicle Biogenesis 31 8.91e-01 -1.42e-02 9.71e-01
Axon guidance 437 6.19e-01 1.40e-02 8.51e-01
Clathrin-mediated endocytosis 122 7.94e-01 -1.37e-02 9.35e-01
Unfolded Protein Response (UPR) 84 8.29e-01 1.37e-02 9.48e-01
RNA Polymerase I Transcription 49 8.72e-01 -1.34e-02 9.65e-01
Intrinsic Pathway for Apoptosis 44 8.81e-01 1.31e-02 9.70e-01
IRS-related events triggered by IGF1R 39 8.89e-01 1.29e-02 9.71e-01
Signaling by BMP 21 9.18e-01 -1.29e-02 9.78e-01
EPHA-mediated growth cone collapse 14 9.36e-01 1.24e-02 9.83e-01
PIWI-interacting RNA (piRNA) biogenesis 18 9.28e-01 1.24e-02 9.80e-01
MAPK1/MAPK3 signaling 237 7.45e-01 -1.23e-02 9.23e-01
Prolonged ERK activation events 14 9.37e-01 -1.23e-02 9.83e-01
Vpr-mediated nuclear import of PICs 29 9.09e-01 -1.22e-02 9.73e-01
AKT phosphorylates targets in the nucleus 10 9.47e-01 1.21e-02 9.85e-01
Golgi-to-ER retrograde transport 106 8.31e-01 1.20e-02 9.48e-01
Recruitment of NuMA to mitotic centrosomes 79 8.54e-01 1.20e-02 9.56e-01
FRS-mediated FGFR3 signaling 14 9.39e-01 1.18e-02 9.85e-01
Advanced glycosylation endproduct receptor signaling 10 9.49e-01 1.16e-02 9.85e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 9.45e-01 1.15e-02 9.85e-01
Myogenesis 23 9.26e-01 -1.12e-02 9.80e-01
Loss of Nlp from mitotic centrosomes 68 8.75e-01 1.11e-02 9.67e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 8.75e-01 1.11e-02 9.67e-01
RNA Polymerase III Transcription Initiation 36 9.09e-01 -1.11e-02 9.73e-01
RNA Polymerase III Chain Elongation 18 9.35e-01 1.10e-02 9.83e-01
FCGR3A-mediated IL10 synthesis 40 9.05e-01 1.09e-02 9.73e-01
EPH-Ephrin signaling 84 8.68e-01 -1.05e-02 9.63e-01
MET activates RAS signaling 10 9.55e-01 -1.02e-02 9.85e-01
Iron uptake and transport 48 9.04e-01 1.00e-02 9.73e-01
Export of Viral Ribonucleoproteins from Nucleus 28 9.27e-01 1.00e-02 9.80e-01
Signaling by FGFR3 31 9.24e-01 9.94e-03 9.80e-01
Insulin receptor signalling cascade 41 9.14e-01 9.75e-03 9.74e-01
Interactions of Vpr with host cellular proteins 31 9.27e-01 -9.56e-03 9.80e-01
Leishmania infection 171 8.30e-01 9.54e-03 9.48e-01
VLDLR internalisation and degradation 11 9.57e-01 9.43e-03 9.86e-01
Interleukin-4 and Interleukin-13 signaling 86 8.80e-01 -9.40e-03 9.70e-01
AMER1 mutants destabilize the destruction complex 13 9.53e-01 9.37e-03 9.85e-01
APC truncation mutants have impaired AXIN binding 13 9.53e-01 9.37e-03 9.85e-01
AXIN missense mutants destabilize the destruction complex 13 9.53e-01 9.37e-03 9.85e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 9.53e-01 9.37e-03 9.85e-01
Truncations of AMER1 destabilize the destruction complex 13 9.53e-01 9.37e-03 9.85e-01
truncated APC mutants destabilize the destruction complex 13 9.53e-01 9.37e-03 9.85e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 9.45e-01 9.32e-03 9.85e-01
Transcriptional activation of mitochondrial biogenesis 50 9.12e-01 -9.04e-03 9.74e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 8.89e-01 -8.83e-03 9.71e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.36e-01 -8.71e-03 9.83e-01
Senescence-Associated Secretory Phenotype (SASP) 44 9.21e-01 -8.67e-03 9.79e-01
Apoptotic execution phase 41 9.24e-01 -8.60e-03 9.80e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 9.49e-01 8.47e-03 9.85e-01
Role of phospholipids in phagocytosis 27 9.40e-01 8.41e-03 9.85e-01
PI3K/AKT Signaling in Cancer 84 8.94e-01 -8.39e-03 9.72e-01
SUMOylation of ubiquitinylation proteins 33 9.35e-01 8.17e-03 9.83e-01
Signaling by FGFR 67 9.08e-01 -8.15e-03 9.73e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 41 9.30e-01 7.92e-03 9.80e-01
Response to elevated platelet cytosolic Ca2+ 107 8.89e-01 7.79e-03 9.71e-01
Downstream signaling of activated FGFR4 18 9.55e-01 -7.74e-03 9.85e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 9.20e-01 7.68e-03 9.79e-01
Norepinephrine Neurotransmitter Release Cycle 11 9.65e-01 7.54e-03 9.87e-01
Signaling by Hedgehog 120 8.87e-01 -7.51e-03 9.71e-01
PI-3K cascade:FGFR4 11 9.66e-01 7.49e-03 9.87e-01
Disease 1139 6.79e-01 7.41e-03 8.88e-01
Transport of Ribonucleoproteins into the Host Nucleus 27 9.47e-01 7.37e-03 9.85e-01
Neurotransmitter release cycle 32 9.43e-01 -7.32e-03 9.85e-01
HIV Life Cycle 133 8.85e-01 7.26e-03 9.70e-01
Nucleobase biosynthesis 15 9.62e-01 7.12e-03 9.87e-01
Negative regulation of the PI3K/AKT network 91 9.07e-01 7.08e-03 9.73e-01
Synthesis of very long-chain fatty acyl-CoAs 14 9.65e-01 -6.78e-03 9.87e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 38 9.44e-01 -6.57e-03 9.85e-01
Anchoring of the basal body to the plasma membrane 92 9.14e-01 -6.55e-03 9.74e-01
Extra-nuclear estrogen signaling 65 9.30e-01 6.33e-03 9.80e-01
RAF activation 34 9.52e-01 -5.99e-03 9.85e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 9.73e-01 -5.96e-03 9.87e-01
RNA Polymerase I Promoter Clearance 48 9.44e-01 -5.89e-03 9.85e-01
HCMV Late Events 48 9.44e-01 -5.88e-03 9.85e-01
Centrosome maturation 80 9.29e-01 5.77e-03 9.80e-01
Recruitment of mitotic centrosome proteins and complexes 80 9.29e-01 5.77e-03 9.80e-01
Pyruvate metabolism 26 9.60e-01 5.74e-03 9.87e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 169 9.01e-01 -5.56e-03 9.73e-01
Amyloid fiber formation 36 9.54e-01 5.55e-03 9.85e-01
MET promotes cell motility 28 9.60e-01 -5.49e-03 9.87e-01
WNT ligand biogenesis and trafficking 14 9.72e-01 -5.39e-03 9.87e-01
Negative regulation of FGFR1 signaling 21 9.67e-01 5.28e-03 9.87e-01
G-protein beta:gamma signalling 28 9.62e-01 5.25e-03 9.87e-01
Plasma lipoprotein assembly 10 9.78e-01 5.06e-03 9.90e-01
Other semaphorin interactions 19 9.72e-01 4.70e-03 9.87e-01
Degradation of cysteine and homocysteine 12 9.78e-01 4.68e-03 9.90e-01
Gap junction trafficking and regulation 16 9.75e-01 -4.56e-03 9.88e-01
Signaling by Erythropoietin 24 9.69e-01 -4.54e-03 9.87e-01
PIP3 activates AKT signaling 238 9.09e-01 4.33e-03 9.73e-01
Keratan sulfate degradation 10 9.81e-01 4.32e-03 9.92e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 27 9.72e-01 -3.94e-03 9.87e-01
IRS-mediated signalling 36 9.69e-01 3.81e-03 9.87e-01
Signaling by high-kinase activity BRAF mutants 30 9.75e-01 -3.30e-03 9.88e-01
SUMOylation of RNA binding proteins 41 9.72e-01 3.13e-03 9.87e-01
Integrin signaling 24 9.80e-01 3.01e-03 9.91e-01
Mitochondrial biogenesis 70 9.66e-01 -2.92e-03 9.87e-01
tRNA processing 107 9.63e-01 2.61e-03 9.87e-01
Peptide ligand-binding receptors 72 9.70e-01 2.55e-03 9.87e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 9.87e-01 -2.48e-03 9.95e-01
Nervous system development 455 9.49e-01 1.77e-03 9.85e-01
VEGFR2 mediated vascular permeability 27 9.89e-01 -1.57e-03 9.96e-01
Signaling by Hippo 20 9.91e-01 -1.47e-03 9.96e-01
Protein folding 87 9.83e-01 1.34e-03 9.92e-01
Activation of HOX genes during differentiation 54 9.91e-01 8.90e-04 9.96e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 54 9.91e-01 8.90e-04 9.96e-01
Developmental Biology 686 9.71e-01 -8.23e-04 9.87e-01
Signaling by Nuclear Receptors 200 9.87e-01 6.89e-04 9.95e-01
Asymmetric localization of PCP proteins 58 9.93e-01 -6.88e-04 9.96e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.97e-01 6.01e-04 9.99e-01
Interleukin-1 family signaling 115 9.92e-01 -5.74e-04 9.96e-01
Endogenous sterols 19 9.97e-01 5.69e-04 9.99e-01
HATs acetylate histones 75 9.98e-01 1.47e-04 1.00e+00
ROS and RNS production in phagocytes 28 9.99e-01 -1.25e-04 1.00e+00
Translocation of SLC2A4 (GLUT4) to the plasma membrane 51 1.00e+00 -2.99e-05 1.00e+00


Detailed Gene set reports



Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion
339
set Establishment of Sister Chromatid Cohesion
setSize 10
pANOVA 8.94e-05
s.dist 0.715
p.adjustANOVA 0.00148



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD21 6600
STAG2 6332
PDS5B 5886
SMC1A 5757
STAG1 5623
CDCA5 5608
ESCO2 5506
ESCO1 5283
SMC3 4863
PDS5A -2866

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD21 6600
STAG2 6332
PDS5B 5886
SMC1A 5757
STAG1 5623
CDCA5 5608
ESCO2 5506
ESCO1 5283
SMC3 4863
PDS5A -2866


Unwinding of DNA

Unwinding of DNA
1278
set Unwinding of DNA
setSize 12
pANOVA 2.56e-05
s.dist 0.702
p.adjustANOVA 0.000512



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM6 6416
GINS4 6023
CDC45 5799
MCM4 5715
MCM5 5639
GINS1 5456
MCM7 5116
MCM2 4543
MCM3 3995
GINS2 3810
MCM8 2679
GINS3 2030

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM6 6416
GINS4 6023
CDC45 5799
MCM4 5715
MCM5 5639
GINS1 5456
MCM7 5116
MCM2 4543
MCM3 3995
GINS2 3810
MCM8 2679
GINS3 2030


Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis
663
set Mitotic Telophase/Cytokinesis
setSize 12
pANOVA 5.57e-05
s.dist 0.672
p.adjustANOVA 0.00104



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD21 6600
STAG2 6332
PDS5B 5886
KIF23 5807
SMC1A 5757
STAG1 5623
SMC3 4863
PLK1 4607
NIPBL 4350
KIF20A 4294
MAU2 3612
PDS5A -2866

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD21 6600
STAG2 6332
PDS5B 5886
KIF23 5807
SMC1A 5757
STAG1 5623
SMC3 4863
PLK1 4607
NIPBL 4350
KIF20A 4294
MAU2 3612
PDS5A -2866


Viral mRNA Translation

Viral mRNA Translation
1289
set Viral mRNA Translation
setSize 55
pANOVA 4.87e-15
s.dist 0.61
p.adjustANOVA 2.17e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
DNAJC3 5104
RPS18 5100
RPS20 5062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
DNAJC3 5104
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
GRSF1 4137
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
RPS26 2036
RPS27A 2027
RPL22 1849
RPL28 1575
RPL18 1455
RPL37 775
RPL3 -198
RPS29 -668


Peptide chain elongation

Peptide chain elongation
790
set Peptide chain elongation
setSize 55
pANOVA 1.22e-14
s.dist 0.601
p.adjustANOVA 2.72e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
EEF1A1 5200
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
EEF1A1 5200
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
RPS26 2036
RPS27A 2027
RPL22 1849
RPL28 1575
RPL18 1455
EEF2 786
RPL37 775
RPL3 -198
RPS29 -668


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
986
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 65
pANOVA 2.69e-16
s.dist 0.587
p.adjustANOVA 1.8e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
DDIT3 6673
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
ATF4 6272
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
ATF2 5661
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DDIT3 6673
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
ATF4 6272
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
ATF2 5661
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
EIF2S1 4996
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
TRIB3 4577
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
EIF2S2 3887
CEBPB 3882
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
EIF2AK4 2782
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
IMPACT 2224
RPL15 2190
RPS26 2036
RPS27A 2027
CEBPG 1967
RPL22 1849
RPL28 1575
RPL18 1455
ASNS 935
RPL37 775
RPL3 -198
RPS29 -668
ATF3 -3157


Activation of the pre-replicative complex

Activation of the pre-replicative complex
53
set Activation of the pre-replicative complex
setSize 31
pANOVA 1.94e-08
s.dist 0.583
p.adjustANOVA 8.67e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 6512
MCM6 6416
RPA2 6100
CDC6 5816
CDC45 5799
MCM4 5715
MCM5 5639
PRIM1 5620
POLE 5575
POLE3 5574
CDK2 5572
ORC2 5275
CDT1 5203
MCM7 5116
POLE4 4549
MCM2 4543
MCM10 4343
ORC3 4206
MCM3 3995
CDC7 3718

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 6512
MCM6 6416
RPA2 6100
CDC6 5816
CDC45 5799
MCM4 5715
MCM5 5639
PRIM1 5620
POLE 5575
POLE3 5574
CDK2 5572
ORC2 5275
CDT1 5203
MCM7 5116
POLE4 4549
MCM2 4543
MCM10 4343
ORC3 4206
MCM3 3995
CDC7 3718
ORC6 3213
ORC5 3106
DBF4 2779
MCM8 2679
RPA1 2677
RPA3 1952
POLE2 1625
ORC4 1442
GMNN 1415
PRIM2 285
POLA2 -3033


Selenocysteine synthesis

Selenocysteine synthesis
1037
set Selenocysteine synthesis
setSize 58
pANOVA 6.68e-14
s.dist 0.569
p.adjustANOVA 1.12e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
PSTK 5969
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
PSTK 5969
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
RPS26 2036
RPS27A 2027
EEFSEC 2014
RPL22 1849
RPL28 1575
RPL18 1455
SECISBP2 1247
SEPHS2 1245
RPL37 775
RPL3 -198
RPS29 -668
SEPSECS -4554


Eukaryotic Translation Termination

Eukaryotic Translation Termination
344
set Eukaryotic Translation Termination
setSize 58
pANOVA 1.86e-13
s.dist 0.559
p.adjustANOVA 2.76e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
N6AMT1 3929
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
ETF1 2162
RPS26 2036
RPS27A 2027
GSPT1 1864
RPL22 1849
RPL28 1575
RPL18 1455
RPL37 775
RPL3 -198
RPS29 -668
GSPT2 -1207
APEH -4725


Glucuronidation

Glucuronidation
440
set Glucuronidation
setSize 11
pANOVA 0.00135
s.dist 0.558
p.adjustANOVA 0.0149



Top enriched genes

Top 20 genes
GeneID Gene Rank
UGT3A1 6714.5
UGT3A2 6714.5
UGT1A10 5030.5
UGT1A7 5030.5
UGT1A8 5030.5
UGT1A9 5030.5
UGT1A6 3947.0
SLC35D1 3277.0
ABHD10 2437.0
UGDH 2303.0
UGP2 -3431.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UGT3A1 6714.5
UGT3A2 6714.5
UGT1A10 5030.5
UGT1A7 5030.5
UGT1A8 5030.5
UGT1A9 5030.5
UGT1A6 3947.0
SLC35D1 3277.0
ABHD10 2437.0
UGDH 2303.0
UGP2 -3431.0


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
342
set Eukaryotic Translation Elongation
setSize 59
pANOVA 6.46e-13
s.dist 0.541
p.adjustANOVA 7.21e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
EEF1A1 5200
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
EEF1A1 5200
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
EEF1B2 4126
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
RPS26 2036
RPS27A 2027
RPL22 1849
RPL28 1575
RPL18 1455
EEF2 786
RPL37 775
RPL3 -198
RPS29 -668
EEF1G -2431
EEF1D -2481
EEF1A2 -6090


DNA strand elongation

DNA strand elongation
244
set DNA strand elongation
setSize 32
pANOVA 1.24e-07
s.dist 0.54
p.adjustANOVA 4.48e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 6512
MCM6 6416
PCNA 6290
RPA2 6100
GINS4 6023
CDC45 5799
MCM4 5715
MCM5 5639
PRIM1 5620
GINS1 5456
RFC2 5411
LIG1 5337
MCM7 5116
POLD3 4916
MCM2 4543
MCM3 3995
GINS2 3810
FEN1 3622
POLD2 3621
RFC5 3279

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 6512
MCM6 6416
PCNA 6290
RPA2 6100
GINS4 6023
CDC45 5799
MCM4 5715
MCM5 5639
PRIM1 5620
GINS1 5456
RFC2 5411
LIG1 5337
MCM7 5116
POLD3 4916
MCM2 4543
MCM3 3995
GINS2 3810
FEN1 3622
POLD2 3621
RFC5 3279
POLD4 2902
MCM8 2679
RPA1 2677
GINS3 2030
POLD1 2021
DNA2 1978
RPA3 1952
RFC4 1833
RFC1 1775
PRIM2 285
RFC3 -1905
POLA2 -3033


Condensation of Prophase Chromosomes

Condensation of Prophase Chromosomes
203
set Condensation of Prophase Chromosomes
setSize 13
pANOVA 0.000883
s.dist 0.533
p.adjustANOVA 0.0101



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCNB1 6494
SMC2 6419
NCAPG2 6376
CDK1 5752
SET 5532
SMC4 5130
PLK1 4607
NCAPH2 3678
NCAPD3 3291
H2AFX 3183
PHF8 69
RB1 -1343
MCPH1 -1647

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNB1 6494
SMC2 6419
NCAPG2 6376
CDK1 5752
SET 5532
SMC4 5130
PLK1 4607
NCAPH2 3678
NCAPD3 3291
H2AFX 3183
PHF8 69
RB1 -1343
MCPH1 -1647


Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
202
set Condensation of Prometaphase Chromosomes
setSize 11
pANOVA 0.00238
s.dist 0.529
p.adjustANOVA 0.0234



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCNB1 6494.0
SMC2 6419.0
NCAPG 6386.0
NCAPH 6079.0
CDK1 5752.0
SMC4 5130.0
CCNB2 4898.0
CSNK2A2 701.0
NCAPD2 584.0
CSNK2B -339.5
CSNK2A1 -2137.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNB1 6494.0
SMC2 6419.0
NCAPG 6386.0
NCAPH 6079.0
CDK1 5752.0
SMC4 5130.0
CCNB2 4898.0
CSNK2A2 701.0
NCAPD2 584.0
CSNK2B -339.5
CSNK2A1 -2137.0


Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
294
set Dissolution of Fibrin Clot
setSize 10
pANOVA 0.00458
s.dist 0.518
p.adjustANOVA 0.039



Top enriched genes

Top 20 genes
GeneID Gene Rank
SERPINF2 6608
S100A10 6293
SERPINE1 5541
ANXA2 5133
PLAUR 5058
SERPINE2 4099
SERPINB6 3102
SERPINB8 2295
PLAU 1267
PLAT -3795

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All member genes
GeneID Gene Rank
SERPINF2 6608
S100A10 6293
SERPINE1 5541
ANXA2 5133
PLAUR 5058
SERPINE2 4099
SERPINB6 3102
SERPINB8 2295
PLAU 1267
PLAT -3795


Polo-like kinase mediated events

Polo-like kinase mediated events
814
set Polo-like kinase mediated events
setSize 15
pANOVA 0.000545
s.dist 0.516
p.adjustANOVA 0.00682



Top enriched genes

Top 20 genes
GeneID Gene Rank
WEE1 6719
CCNB1 6494
LIN52 6193
MYBL2 5599
CENPF 5326
RBBP4 5147
CCNB2 4898
FOXM1 4897
PLK1 4607
LIN9 3491
LIN54 2783
PKMYT1 1250
CDC25A -152
EP300 -262
LIN37 -3826

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WEE1 6719
CCNB1 6494
LIN52 6193
MYBL2 5599
CENPF 5326
RBBP4 5147
CCNB2 4898
FOXM1 4897
PLK1 4607
LIN9 3491
LIN54 2783
PKMYT1 1250
CDC25A -152
EP300 -262
LIN37 -3826


Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition
220
set Cyclin A/B1/B2 associated events during G2/M transition
setSize 22
pANOVA 3.2e-05
s.dist 0.512
p.adjustANOVA 0.000621



Top enriched genes

Top 20 genes
GeneID Gene Rank
WEE1 6719
CCNB1 6494
CCNA2 6489
XPO1 6429
CDC25B 6277
CDK1 5752
CDK2 5572
CCNB2 4898
FOXM1 4897
PLK1 4607
PPP2R1B 4341
PPP2CA 4328
CCNH 3657
PPP2CB 3439
CDK7 2131
PPME1 1417
PKMYT1 1250
MNAT1 1064
PPP2R2A 872
CDC25A -152

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WEE1 6719
CCNB1 6494
CCNA2 6489
XPO1 6429
CDC25B 6277
CDK1 5752
CDK2 5572
CCNB2 4898
FOXM1 4897
PLK1 4607
PPP2R1B 4341
PPP2CA 4328
CCNH 3657
PPP2CB 3439
CDK7 2131
PPME1 1417
PKMYT1 1250
MNAT1 1064
PPP2R2A 872
CDC25A -152
LCMT1 -233
PPP2R1A -2809


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
725
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 60
pANOVA 9.09e-12
s.dist 0.509
p.adjustANOVA 5.53e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
RPS9 3818
RPL38 3732
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
ETF1 2162
RPS26 2036
RPS27A 2027
GSPT1 1864
RPL22 1849
RPL28 1575
RPL18 1455
RPL37 775
RPL3 -198
RPS29 -668
NCBP1 -1003
GSPT2 -1207
UPF1 -3282
EIF4G1 -3686
NCBP2 -4668


HSF1-dependent transactivation

HSF1-dependent transactivation
476
set HSF1-dependent transactivation
setSize 32
pANOVA 6.86e-07
s.dist -0.507
p.adjustANOVA 2.14e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPB8 -6339.0
CAMK2B -6330.0
HSPH1 -6239.0
HSF1 -6178.0
HSPA1L -6041.0
HSPA1A -5937.5
HSPA1B -5937.5
CRYAB -5933.0
SERPINH1 -5894.0
RPTOR -5776.0
FKBP4 -5661.0
HSP90AB1 -5490.0
CAMK2G -5251.0
CRYBA4 -5240.0
HSPA2 -5016.0
MLST8 -4683.0
DNAJB6 -4396.0
HSP90AA1 -3889.0
COL4A6 -3732.0
MTOR -3559.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPB8 -6339.0
CAMK2B -6330.0
HSPH1 -6239.0
HSF1 -6178.0
HSPA1L -6041.0
HSPA1A -5937.5
HSPA1B -5937.5
CRYAB -5933.0
SERPINH1 -5894.0
RPTOR -5776.0
FKBP4 -5661.0
HSP90AB1 -5490.0
CAMK2G -5251.0
CRYBA4 -5240.0
HSPA2 -5016.0
MLST8 -4683.0
DNAJB6 -4396.0
HSP90AA1 -3889.0
COL4A6 -3732.0
MTOR -3559.0
CAMK2D -2834.0
CREBBP -2187.0
HSBP1 -1978.0
HSPA8 -1092.0
DNAJB1 -908.0
EP300 -262.0
AKT1S1 -258.0
CAMK2A 862.0
TNFRSF21 2049.0
MRPL18 2785.0
DEDD2 4658.0
PTGES3 5102.0


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
382
set Formation of a pool of free 40S subunits
setSize 65
pANOVA 2.8e-12
s.dist 0.501
p.adjustANOVA 2.34e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
EIF3E 5539
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577.0
RPS12 6555.0
RPL10 6544.0
RPS27L 6535.0
RPS27 6213.0
RPL36A 6168.0
RPS24 6142.0
RPS15A 6000.0
RPS4X 5880.0
RPL4 5769.0
RPL5 5750.0
RPL7 5591.0
EIF3E 5539.0
RPL32 5477.0
RPL26 5321.0
RPS23 5172.0
RPL23 5139.0
RPS3 5117.0
RPS18 5100.0
RPS20 5062.0
RPS5 4999.0
RPS8 4889.0
RPL11 4820.0
RPL3L 4800.0
RPL8 4610.0
RPS13 4582.0
RPL34 4469.0
RPL37A 4369.0
RPL30 4353.0
RPS19 4331.0
RPL19 4310.0
EIF3M 4156.0
RPLP2 4122.0
RPL35A 4089.0
RPS6 4076.0
RPL18A 4046.0
RPL14 3980.0
RPS9 3818.0
RPL38 3732.0
EIF3H 3301.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
RPL31 2728.0
RPS15 2680.0
RPS14 2662.0
EIF3F 2512.0
FAU 2504.0
RPL15 2190.0
RPS26 2036.0
RPS27A 2027.0
RPL22 1849.0
RPL28 1575.0
RPL18 1455.0
RPL37 775.0
EIF3G 675.0
EIF3I 488.0
EIF3K -23.0
RPL3 -198.0
RPS29 -668.0
EIF3A -942.0
EIF3D -1521.0
EIF3B -2568.0
EIF3C -3429.5
EIF3L -4005.0


Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists
706
set Negative regulation of TCF-dependent signaling by WNT ligand antagonists
setSize 11
pANOVA 0.00471
s.dist -0.492
p.adjustANOVA 0.0399



Top enriched genes

Top 20 genes
GeneID Gene Rank
KREMEN1 -6335.0
LRP5 -5909.5
WNT9A -5315.0
WNT5A -5200.0
SOST -4235.0
SFRP2 -3821.0
LRP6 -3028.0
KREMEN2 -2339.0
WIF1 -1755.0
WNT4 1883.0
SFRP1 2165.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KREMEN1 -6335.0
LRP5 -5909.5
WNT9A -5315.0
WNT5A -5200.0
SOST -4235.0
SFRP2 -3821.0
LRP6 -3028.0
KREMEN2 -2339.0
WIF1 -1755.0
WNT4 1883.0
SFRP1 2165.0


Processive synthesis on the lagging strand

Processive synthesis on the lagging strand
839
set Processive synthesis on the lagging strand
setSize 15
pANOVA 0.000979
s.dist 0.492
p.adjustANOVA 0.011



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 6512
PCNA 6290
RPA2 6100
PRIM1 5620
LIG1 5337
POLD3 4916
FEN1 3622
POLD2 3621
POLD4 2902
RPA1 2677
POLD1 2021
DNA2 1978
RPA3 1952
PRIM2 285
POLA2 -3033

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 6512
PCNA 6290
RPA2 6100
PRIM1 5620
LIG1 5337
POLD3 4916
FEN1 3622
POLD2 3621
POLD4 2902
RPA1 2677
POLD1 2021
DNA2 1978
RPA3 1952
PRIM2 285
POLA2 -3033


Activation of ATR in response to replication stress

Activation of ATR in response to replication stress
35
set Activation of ATR in response to replication stress
setSize 35
pANOVA 6.51e-07
s.dist 0.486
p.adjustANOVA 2.08e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM6 6416
RPA2 6100
CDC6 5816
CDC45 5799
MCM4 5715
MCM5 5639
CDK2 5572
RFC2 5411
ORC2 5275
RAD17 5255
MCM7 5116
CLSPN 4553
MCM2 4543
MCM10 4343
ORC3 4206
MCM3 3995
CDC7 3718
RFC5 3279
ORC6 3213
ORC5 3106

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM6 6416
RPA2 6100
CDC6 5816
CDC45 5799
MCM4 5715
MCM5 5639
CDK2 5572
RFC2 5411
ORC2 5275
RAD17 5255
MCM7 5116
CLSPN 4553
MCM2 4543
MCM10 4343
ORC3 4206
MCM3 3995
CDC7 3718
RFC5 3279
ORC6 3213
ORC5 3106
RAD9A 2924
DBF4 2779
MCM8 2679
RPA1 2677
HUS1 2545
ATR 2460
CHEK1 2267
RPA3 1952
RFC4 1833
ORC4 1442
RAD1 1208
ATRIP 548
CDC25A -152
RFC3 -1905
RAD9B -3263


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1018
set SRP-dependent cotranslational protein targeting to membrane
setSize 76
pANOVA 5.63e-13
s.dist 0.478
p.adjustANOVA 7.21e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
TRAM1 5865
RPL4 5769
RPL5 5750
RPL7 5591
SEC11A 5559
RPL32 5477
SRP54 5436
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
TRAM1 5865
RPL4 5769
RPL5 5750
RPL7 5591
SEC11A 5559
RPL32 5477
SRP54 5436
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
SRP72 5053
RPS5 4999
RPS8 4889
RPL11 4820
RPL3L 4800
SSR4 4753
SSR3 4638
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
RPS19 4331
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
RPS9 3818
RPL38 3732
SEC61G 3595
SEC61A2 3541
RPS21 3125
RPS11 3037
SPCS2 2945
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
RPL15 2190
SPCS3 2118
SRP9 2075
RPS26 2036
RPS27A 2027
RPL22 1849
SEC11C 1631
RPL28 1575
SRP19 1462
RPL18 1455
RPL37 775
SRP14 243
SRP68 198
RPL3 -198
SPCS1 -416
RPS29 -668
SSR1 -1144
SEC61A1 -1302
RPN2 -1773
SSR2 -2413
DDOST -3106
RPN1 -3802
SRPRB -4722


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
571
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 73
pANOVA 1.65e-12
s.dist 0.478
p.adjustANOVA 1.55e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
EIF4A1 6352
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
EIF3E 5539
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577.0
RPS12 6555.0
RPL10 6544.0
RPS27L 6535.0
EIF4A1 6352.0
RPS27 6213.0
RPL36A 6168.0
RPS24 6142.0
RPS15A 6000.0
RPS4X 5880.0
RPL4 5769.0
RPL5 5750.0
RPL7 5591.0
EIF3E 5539.0
RPL32 5477.0
RPL26 5321.0
RPS23 5172.0
RPL23 5139.0
RPS3 5117.0
RPS18 5100.0
RPS20 5062.0
RPS5 4999.0
EIF2S1 4996.0
RPS8 4889.0
RPL11 4820.0
RPL3L 4800.0
RPL8 4610.0
RPS13 4582.0
RPL34 4469.0
RPL37A 4369.0
RPL30 4353.0
RPS19 4331.0
RPL19 4310.0
EIF3M 4156.0
RPLP2 4122.0
RPL35A 4089.0
RPS6 4076.0
RPL18A 4046.0
EIF4B 3994.0
RPL14 3980.0
EIF2S2 3887.0
RPS9 3818.0
RPL38 3732.0
EIF3H 3301.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
RPL31 2728.0
RPS15 2680.0
RPS14 2662.0
EIF4H 2589.0
EIF3F 2512.0
FAU 2504.0
RPL15 2190.0
RPS26 2036.0
RPS27A 2027.0
RPL22 1849.0
RPL28 1575.0
RPL18 1455.0
EIF4A2 1422.0
RPL37 775.0
EIF3G 675.0
EIF3I 488.0
EIF3K -23.0
RPL3 -198.0
RPS29 -668.0
EIF3A -942.0
EIF3D -1521.0
EIF3B -2568.0
EIF4E -3260.0
EIF3C -3429.5
EIF4G1 -3686.0
EIF3L -4005.0


Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
1227
set Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
setSize 15
pANOVA 0.00138
s.dist 0.477
p.adjustANOVA 0.0151



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFDP2 6504.0
CCNA2 6489.0
RBL1 6216.0
LIN52 6193.0
CDK1 5752.0
E2F1 5631.0
MYBL2 5599.0
RBBP4 5147.0
RBL2 4767.0
LIN9 3491.0
LIN54 2783.0
E2F5 2291.0
E2F4 -2498.0
LIN37 -3826.0
TFDP1 -5186.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFDP2 6504.0
CCNA2 6489.0
RBL1 6216.0
LIN52 6193.0
CDK1 5752.0
E2F1 5631.0
MYBL2 5599.0
RBBP4 5147.0
RBL2 4767.0
LIN9 3491.0
LIN54 2783.0
E2F5 2291.0
E2F4 -2498.0
LIN37 -3826.0
TFDP1 -5186.5


Selenoamino acid metabolism

Selenoamino acid metabolism
1036
set Selenoamino acid metabolism
setSize 72
pANOVA 3.56e-12
s.dist 0.474
p.adjustANOVA 2.81e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
PSTK 5969
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117
RPS18 5100
CBS 5099

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577.0
RPS12 6555.0
RPL10 6544.0
RPS27L 6535.0
RPS27 6213.0
RPL36A 6168.0
RPS24 6142.0
RPS15A 6000.0
PSTK 5969.0
RPS4X 5880.0
RPL4 5769.0
RPL5 5750.0
RPL7 5591.0
RPL32 5477.0
RPL26 5321.0
RPS23 5172.0
RPL23 5139.0
RPS3 5117.0
RPS18 5100.0
CBS 5099.0
RPS20 5062.0
RPS5 4999.0
CTH 4893.0
RPS8 4889.0
RPL11 4820.0
RPL3L 4800.0
GNMT 4656.0
RPL8 4610.0
RPS13 4582.0
RPL34 4469.0
HNMT 4371.0
RPL37A 4369.0
RPL30 4353.0
RPS19 4331.0
RPL19 4310.0
RPLP2 4122.0
RPL35A 4089.0
RPS6 4076.0
RPL18A 4046.0
RPL14 3980.0
RPS9 3818.0
RPL38 3732.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
AHCY 2811.0
RPL31 2728.0
RPS15 2680.0
RPS14 2662.0
FAU 2504.0
RPL15 2190.0
RPS26 2036.0
RPS27A 2027.0
EEFSEC 2014.0
NNMT 1942.0
RPL22 1849.0
RPL28 1575.0
PAPSS2 1488.0
RPL18 1455.0
SECISBP2 1247.0
SEPHS2 1245.0
RPL37 775.0
AIMP1 406.0
EEF1E1 218.5
RPL3 -198.0
RPS29 -668.0
PAPSS1 -1112.0
TXNRD1 -2127.0
AIMP2 -3345.0
SEPSECS -4554.0
GSR -4617.0
SCLY -5290.0


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
422
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 75
pANOVA 1.74e-12
s.dist 0.471
p.adjustANOVA 1.55e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
EIF4A1 6352
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
EIF5 5902
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
EIF3E 5539
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139
RPS3 5117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577.0
RPS12 6555.0
RPL10 6544.0
RPS27L 6535.0
EIF4A1 6352.0
RPS27 6213.0
RPL36A 6168.0
RPS24 6142.0
RPS15A 6000.0
EIF5 5902.0
RPS4X 5880.0
RPL4 5769.0
RPL5 5750.0
RPL7 5591.0
EIF3E 5539.0
RPL32 5477.0
RPL26 5321.0
RPS23 5172.0
RPL23 5139.0
RPS3 5117.0
RPS18 5100.0
RPS20 5062.0
RPS5 4999.0
EIF2S1 4996.0
RPS8 4889.0
RPL11 4820.0
RPL3L 4800.0
RPL8 4610.0
RPS13 4582.0
RPL34 4469.0
RPL37A 4369.0
RPL30 4353.0
RPS19 4331.0
RPL19 4310.0
EIF3M 4156.0
RPLP2 4122.0
RPL35A 4089.0
RPS6 4076.0
RPL18A 4046.0
EIF4B 3994.0
RPL14 3980.0
EIF2S2 3887.0
RPS9 3818.0
RPL38 3732.0
EIF3H 3301.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
RPL31 2728.0
RPS15 2680.0
RPS14 2662.0
EIF4H 2589.0
EIF3F 2512.0
FAU 2504.0
RPL15 2190.0
RPS26 2036.0
RPS27A 2027.0
RPL22 1849.0
RPL28 1575.0
RPL18 1455.0
EIF4A2 1422.0
RPL37 775.0
EIF3G 675.0
EIF3I 488.0
EIF3K -23.0
RPL3 -198.0
RPS29 -668.0
EIF3A -942.0
EIF3D -1521.0
EIF3B -2568.0
EIF5B -2738.0
EIF4E -3260.0
EIF3C -3429.5
EIF4G1 -3686.0
EIF3L -4005.0


Removal of the Flap Intermediate

Removal of the Flap Intermediate
973
set Removal of the Flap Intermediate
setSize 14
pANOVA 0.00231
s.dist 0.47
p.adjustANOVA 0.0229



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 6512
PCNA 6290
RPA2 6100
PRIM1 5620
POLD3 4916
FEN1 3622
POLD2 3621
POLD4 2902
RPA1 2677
POLD1 2021
DNA2 1978
RPA3 1952
PRIM2 285
POLA2 -3033

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 6512
PCNA 6290
RPA2 6100
PRIM1 5620
POLD3 4916
FEN1 3622
POLD2 3621
POLD4 2902
RPA1 2677
POLD1 2021
DNA2 1978
RPA3 1952
PRIM2 285
POLA2 -3033


LGI-ADAM interactions

LGI-ADAM interactions
574
set LGI-ADAM interactions
setSize 11
pANOVA 0.00718
s.dist -0.468
p.adjustANOVA 0.0529



Top enriched genes

Top 20 genes
GeneID Gene Rank
LGI1 -6159
ADAM11 -6067
STX1B -5608
LGI4 -5284
LGI3 -4643
LGI2 -4508
STX1A -2845
ADAM23 -1841
DLG4 -1769
CACNG2 115
ADAM22 6455

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LGI1 -6159
ADAM11 -6067
STX1B -5608
LGI4 -5284
LGI3 -4643
LGI2 -4508
STX1A -2845
ADAM23 -1841
DLG4 -1769
CACNG2 115
ADAM22 6455


G0 and Early G1

G0 and Early G1
404
set G0 and Early G1
setSize 25
pANOVA 6.17e-05
s.dist 0.463
p.adjustANOVA 0.00109



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAX 6562
TFDP2 6504
CCNA2 6489
PCNA 6290
RBL1 6216
LIN52 6193
CDC6 5816
CDK1 5752
E2F1 5631
MYBL2 5599
CDK2 5572
TOP2A 5473
RBBP4 5147
RBL2 4767
CCNE2 3602
LIN9 3491
LIN54 2783
DYRK1A 2724
E2F5 2291
CDC25A -152

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAX 6562.0
TFDP2 6504.0
CCNA2 6489.0
PCNA 6290.0
RBL1 6216.0
LIN52 6193.0
CDC6 5816.0
CDK1 5752.0
E2F1 5631.0
MYBL2 5599.0
CDK2 5572.0
TOP2A 5473.0
RBBP4 5147.0
RBL2 4767.0
CCNE2 3602.0
LIN9 3491.0
LIN54 2783.0
DYRK1A 2724.0
E2F5 2291.0
CDC25A -152.0
CCNE1 -892.0
E2F4 -2498.0
LIN37 -3826.0
MYC -4460.0
TFDP1 -5186.5


Recognition of DNA damage by PCNA-containing replication complex

Recognition of DNA damage by PCNA-containing replication complex
918
set Recognition of DNA damage by PCNA-containing replication complex
setSize 28
pANOVA 2.89e-05
s.dist 0.457
p.adjustANOVA 0.00057



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCNA 6290
UBE2B 6136
RPA2 6100
CUL4B 5748
POLE 5575
POLE3 5574
RFC2 5411
DTL 5004
POLD3 4916
USP1 4805
RAD18 4562
POLE4 4549
RBX1 3837
POLD2 3621
RFC5 3279
POLD4 2902
WDR48 2758
RPA1 2677
RPS27A 2027
POLD1 2021

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCNA 6290
UBE2B 6136
RPA2 6100
CUL4B 5748
POLE 5575
POLE3 5574
RFC2 5411
DTL 5004
POLD3 4916
USP1 4805
RAD18 4562
POLE4 4549
RBX1 3837
POLD2 3621
RFC5 3279
POLD4 2902
WDR48 2758
RPA1 2677
RPS27A 2027
POLD1 2021
RPA3 1952
RFC4 1833
RFC1 1775
POLE2 1625
DDB1 1560
CUL4A 71
RFC3 -1905
UBC -6404


G1/S-Specific Transcription

G1/S-Specific Transcription
408
set G1/S-Specific Transcription
setSize 26
pANOVA 6.73e-05
s.dist 0.452
p.adjustANOVA 0.00117



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 6512.0
TFDP2 6504.0
PCNA 6290.0
RBL1 6216.0
LIN52 6193.0
CDC6 5816.0
CDC45 5799.0
CDK1 5752.0
RRM2 5739.0
TK1 5665.0
E2F1 5631.0
CDT1 5203.0
FBXO5 5187.0
RBBP4 5147.0
RBL2 4767.0
DHFR 3663.5
LIN9 3491.0
LIN54 2783.0
E2F5 2291.0
CDC25A -152.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 6512.0
TFDP2 6504.0
PCNA 6290.0
RBL1 6216.0
LIN52 6193.0
CDC6 5816.0
CDC45 5799.0
CDK1 5752.0
RRM2 5739.0
TK1 5665.0
E2F1 5631.0
CDT1 5203.0
FBXO5 5187.0
RBBP4 5147.0
RBL2 4767.0
DHFR 3663.5
LIN9 3491.0
LIN54 2783.0
E2F5 2291.0
CDC25A -152.0
CCNE1 -892.0
E2F6 -2305.0
E2F4 -2498.0
TYMS -2640.0
LIN37 -3826.0
TFDP1 -5186.5


Constitutive Signaling by NOTCH1 HD Domain Mutants

Constitutive Signaling by NOTCH1 HD Domain Mutants
208
set Constitutive Signaling by NOTCH1 HD Domain Mutants
setSize 12
pANOVA 0.00692
s.dist -0.45
p.adjustANOVA 0.0515



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -6404
DLL1 -6028
ADAM17 -5641
NOTCH1 -5482
DLL4 -5274
JAG2 -4948
JAG1 -2597
NEURL1B -2029
MIB2 -954
ADAM10 -825
RPS27A 2027
MIB1 4489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -6404
DLL1 -6028
ADAM17 -5641
NOTCH1 -5482
DLL4 -5274
JAG2 -4948
JAG1 -2597
NEURL1B -2029
MIB2 -954
ADAM10 -825
RPS27A 2027
MIB1 4489


Signaling by NOTCH1 HD Domain Mutants in Cancer

Signaling by NOTCH1 HD Domain Mutants in Cancer
1088
set Signaling by NOTCH1 HD Domain Mutants in Cancer
setSize 12
pANOVA 0.00692
s.dist -0.45
p.adjustANOVA 0.0515



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -6404
DLL1 -6028
ADAM17 -5641
NOTCH1 -5482
DLL4 -5274
JAG2 -4948
JAG1 -2597
NEURL1B -2029
MIB2 -954
ADAM10 -825
RPS27A 2027
MIB1 4489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -6404
DLL1 -6028
ADAM17 -5641
NOTCH1 -5482
DLL4 -5274
JAG2 -4948
JAG1 -2597
NEURL1B -2029
MIB2 -954
ADAM10 -825
RPS27A 2027
MIB1 4489


Attenuation phase

Attenuation phase
93
set Attenuation phase
setSize 22
pANOVA 0.000267
s.dist -0.449
p.adjustANOVA 0.00373



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPH1 -6239.0
HSF1 -6178.0
HSPA1L -6041.0
HSPA1A -5937.5
HSPA1B -5937.5
SERPINH1 -5894.0
FKBP4 -5661.0
HSP90AB1 -5490.0
CRYBA4 -5240.0
HSPA2 -5016.0
DNAJB6 -4396.0
HSP90AA1 -3889.0
COL4A6 -3732.0
CREBBP -2187.0
HSBP1 -1978.0
HSPA8 -1092.0
DNAJB1 -908.0
EP300 -262.0
TNFRSF21 2049.0
MRPL18 2785.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPH1 -6239.0
HSF1 -6178.0
HSPA1L -6041.0
HSPA1A -5937.5
HSPA1B -5937.5
SERPINH1 -5894.0
FKBP4 -5661.0
HSP90AB1 -5490.0
CRYBA4 -5240.0
HSPA2 -5016.0
DNAJB6 -4396.0
HSP90AA1 -3889.0
COL4A6 -3732.0
CREBBP -2187.0
HSBP1 -1978.0
HSPA8 -1092.0
DNAJB1 -908.0
EP300 -262.0
TNFRSF21 2049.0
MRPL18 2785.0
DEDD2 4658.0
PTGES3 5102.0


CDC6 association with the ORC:origin complex

CDC6 association with the ORC:origin complex
124
set CDC6 association with the ORC:origin complex
setSize 10
pANOVA 0.0143
s.dist 0.448
p.adjustANOVA 0.0876



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC6 5816
E2F1 5631
E2F2 5537
ORC2 5275
ORC3 4206
ORC6 3213
ORC5 3106
MCM8 2679
ORC4 1442
E2F3 -5927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC6 5816
E2F1 5631
E2F2 5537
ORC2 5275
ORC3 4206
ORC6 3213
ORC5 3106
MCM8 2679
ORC4 1442
E2F3 -5927


Lagging Strand Synthesis

Lagging Strand Synthesis
575
set Lagging Strand Synthesis
setSize 20
pANOVA 0.000621
s.dist 0.442
p.adjustANOVA 0.00763



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 6512
PCNA 6290
RPA2 6100
PRIM1 5620
RFC2 5411
LIG1 5337
POLD3 4916
FEN1 3622
POLD2 3621
RFC5 3279
POLD4 2902
RPA1 2677
POLD1 2021
DNA2 1978
RPA3 1952
RFC4 1833
RFC1 1775
PRIM2 285
RFC3 -1905
POLA2 -3033

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 6512
PCNA 6290
RPA2 6100
PRIM1 5620
RFC2 5411
LIG1 5337
POLD3 4916
FEN1 3622
POLD2 3621
RFC5 3279
POLD4 2902
RPA1 2677
POLD1 2021
DNA2 1978
RPA3 1952
RFC4 1833
RFC1 1775
PRIM2 285
RFC3 -1905
POLA2 -3033


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
144
set Cap-dependent Translation Initiation
setSize 81
pANOVA 6.39e-12
s.dist 0.442
p.adjustANOVA 4.5e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
EIF4A1 6352
EIF4EBP1 6235
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
EIF5 5902
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
EIF3E 5539
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577.0
RPS12 6555.0
RPL10 6544.0
RPS27L 6535.0
EIF4A1 6352.0
EIF4EBP1 6235.0
RPS27 6213.0
RPL36A 6168.0
RPS24 6142.0
RPS15A 6000.0
EIF5 5902.0
RPS4X 5880.0
RPL4 5769.0
RPL5 5750.0
RPL7 5591.0
EIF3E 5539.0
RPL32 5477.0
RPL26 5321.0
RPS23 5172.0
RPL23 5139.0
RPS3 5117.0
RPS18 5100.0
RPS20 5062.0
RPS5 4999.0
EIF2S1 4996.0
RPS8 4889.0
RPL11 4820.0
RPL3L 4800.0
RPL8 4610.0
RPS13 4582.0
RPL34 4469.0
RPL37A 4369.0
RPL30 4353.0
RPS19 4331.0
RPL19 4310.0
EIF3M 4156.0
RPLP2 4122.0
RPL35A 4089.0
RPS6 4076.0
RPL18A 4046.0
EIF4B 3994.0
RPL14 3980.0
EIF2S2 3887.0
RPS9 3818.0
RPL38 3732.0
EIF3H 3301.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
EIF2B1 2752.0
RPL31 2728.0
RPS15 2680.0
RPS14 2662.0
EIF4H 2589.0
EIF3F 2512.0
FAU 2504.0
RPL15 2190.0
RPS26 2036.0
RPS27A 2027.0
RPL22 1849.0
RPL28 1575.0
RPL18 1455.0
EIF4A2 1422.0
EIF2B5 1193.0
RPL37 775.0
EIF3G 675.0
EIF3I 488.0
EIF3K -23.0
RPL3 -198.0
RPS29 -668.0
EIF3A -942.0
EIF2B3 -1274.0
EIF3D -1521.0
EIF2B2 -1728.0
EIF3B -2568.0
EIF5B -2738.0
EIF4E -3260.0
EIF3C -3429.5
EIF2B4 -3461.0
EIF4G1 -3686.0
EIF3L -4005.0


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
343
set Eukaryotic Translation Initiation
setSize 81
pANOVA 6.39e-12
s.dist 0.442
p.adjustANOVA 4.5e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
EIF4A1 6352
EIF4EBP1 6235
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
EIF5 5902
RPS4X 5880
RPL4 5769
RPL5 5750
RPL7 5591
EIF3E 5539
RPL32 5477
RPL26 5321
RPS23 5172
RPL23 5139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577.0
RPS12 6555.0
RPL10 6544.0
RPS27L 6535.0
EIF4A1 6352.0
EIF4EBP1 6235.0
RPS27 6213.0
RPL36A 6168.0
RPS24 6142.0
RPS15A 6000.0
EIF5 5902.0
RPS4X 5880.0
RPL4 5769.0
RPL5 5750.0
RPL7 5591.0
EIF3E 5539.0
RPL32 5477.0
RPL26 5321.0
RPS23 5172.0
RPL23 5139.0
RPS3 5117.0
RPS18 5100.0
RPS20 5062.0
RPS5 4999.0
EIF2S1 4996.0
RPS8 4889.0
RPL11 4820.0
RPL3L 4800.0
RPL8 4610.0
RPS13 4582.0
RPL34 4469.0
RPL37A 4369.0
RPL30 4353.0
RPS19 4331.0
RPL19 4310.0
EIF3M 4156.0
RPLP2 4122.0
RPL35A 4089.0
RPS6 4076.0
RPL18A 4046.0
EIF4B 3994.0
RPL14 3980.0
EIF2S2 3887.0
RPS9 3818.0
RPL38 3732.0
EIF3H 3301.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
EIF2B1 2752.0
RPL31 2728.0
RPS15 2680.0
RPS14 2662.0
EIF4H 2589.0
EIF3F 2512.0
FAU 2504.0
RPL15 2190.0
RPS26 2036.0
RPS27A 2027.0
RPL22 1849.0
RPL28 1575.0
RPL18 1455.0
EIF4A2 1422.0
EIF2B5 1193.0
RPL37 775.0
EIF3G 675.0
EIF3I 488.0
EIF3K -23.0
RPL3 -198.0
RPS29 -668.0
EIF3A -942.0
EIF2B3 -1274.0
EIF3D -1521.0
EIF2B2 -1728.0
EIF3B -2568.0
EIF5B -2738.0
EIF4E -3260.0
EIF3C -3429.5
EIF2B4 -3461.0
EIF4G1 -3686.0
EIF3L -4005.0


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
724
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 80
pANOVA 8.68e-12
s.dist 0.442
p.adjustANOVA 5.53e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
PNRC2 6454
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RBM8A 5635
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RNPS1 5168
RPL23 5139
RPS3 5117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
PNRC2 6454
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RBM8A 5635
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RNPS1 5168
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
SMG1 4874
MAGOHB 4865
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
MAGOH 4333
RPS19 4331
PPP2CA 4328
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
UPF2 3963
RPS9 3818
RPL38 3732
SMG5 3334
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
UPF3A 2471
RPL15 2190
ETF1 2162
RPS26 2036
RPS27A 2027
SMG8 2015
GSPT1 1864
RPL22 1849
RPL28 1575
RPL18 1455
CASC3 1093
PPP2R2A 872
RPL37 775
SMG6 536
RPL3 -198
RPS29 -668
NCBP1 -1003
GSPT2 -1207
UPF3B -1360
EIF4A3 -1480
SMG7 -2289
PPP2R1A -2809
SMG9 -3069
UPF1 -3282
EIF4G1 -3686
NCBP2 -4668
DCP1A -4832


Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
726
set Nonsense-Mediated Decay (NMD)
setSize 80
pANOVA 8.68e-12
s.dist 0.442
p.adjustANOVA 5.53e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
PNRC2 6454
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RBM8A 5635
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RNPS1 5168
RPL23 5139
RPS3 5117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL22L1 6577
RPS12 6555
RPL10 6544
RPS27L 6535
PNRC2 6454
RPS27 6213
RPL36A 6168
RPS24 6142
RPS15A 6000
RPS4X 5880
RPL4 5769
RPL5 5750
RBM8A 5635
RPL7 5591
RPL32 5477
RPL26 5321
RPS23 5172
RNPS1 5168
RPL23 5139
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
RPS8 4889
SMG1 4874
MAGOHB 4865
RPL11 4820
RPL3L 4800
RPL8 4610
RPS13 4582
RPL34 4469
RPL37A 4369
RPL30 4353
MAGOH 4333
RPS19 4331
PPP2CA 4328
RPL19 4310
RPLP2 4122
RPL35A 4089
RPS6 4076
RPL18A 4046
RPL14 3980
UPF2 3963
RPS9 3818
RPL38 3732
SMG5 3334
RPS21 3125
RPS11 3037
RPS16 2931
RPL31 2728
RPS15 2680
RPS14 2662
FAU 2504
UPF3A 2471
RPL15 2190
ETF1 2162
RPS26 2036
RPS27A 2027
SMG8 2015
GSPT1 1864
RPL22 1849
RPL28 1575
RPL18 1455
CASC3 1093
PPP2R2A 872
RPL37 775
SMG6 536
RPL3 -198
RPS29 -668
NCBP1 -1003
GSPT2 -1207
UPF3B -1360
EIF4A3 -1480
SMG7 -2289
PPP2R1A -2809
SMG9 -3069
UPF1 -3282
EIF4G1 -3686
NCBP2 -4668
DCP1A -4832


Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
643
set Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
setSize 14
pANOVA 0.00425
s.dist 0.441
p.adjustANOVA 0.037



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCNA 6290
RPA2 6100
LIG1 5337
EXO1 5265
POLD3 4916
MSH2 4185
POLD2 3621
POLD4 2902
RPA1 2677
POLD1 2021
RPA3 1952
PMS2 1644
MSH6 -734
MLH1 -3389

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCNA 6290
RPA2 6100
LIG1 5337
EXO1 5265
POLD3 4916
MSH2 4185
POLD2 3621
POLD4 2902
RPA1 2677
POLD1 2021
RPA3 1952
PMS2 1644
MSH6 -734
MLH1 -3389


PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair
759
set PCNA-Dependent Long Patch Base Excision Repair
setSize 21
pANOVA 0.000476
s.dist 0.441
p.adjustANOVA 0.00613



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCNA 6290
RPA2 6100
POLE 5575
POLE3 5574
RFC2 5411
LIG1 5337
POLD3 4916
POLE4 4549
FEN1 3622
POLD2 3621
RFC5 3279
POLD4 2902
RPA1 2677
POLD1 2021
RPA3 1952
RFC4 1833
RFC1 1775
POLE2 1625
POLB -826
RFC3 -1905

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCNA 6290
RPA2 6100
POLE 5575
POLE3 5574
RFC2 5411
LIG1 5337
POLD3 4916
POLE4 4549
FEN1 3622
POLD2 3621
RFC5 3279
POLD4 2902
RPA1 2677
POLD1 2021
RPA3 1952
RFC4 1833
RFC1 1775
POLE2 1625
POLB -826
RFC3 -1905
APEX1 -2297


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
387
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 39
pANOVA 2.34e-06
s.dist 0.437
p.adjustANOVA 5.69e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS12 6555
RPS27L 6535
RPS27 6213
RPS24 6142
RPS15A 6000
RPS4X 5880
EIF3E 5539
RPS23 5172
RPS3 5117
RPS18 5100
RPS20 5062
RPS5 4999
EIF2S1 4996
RPS8 4889
RPS13 4582
RPS19 4331
EIF3M 4156
RPS6 4076
EIF2S2 3887
RPS9 3818

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS12 6555.0
RPS27L 6535.0
RPS27 6213.0
RPS24 6142.0
RPS15A 6000.0
RPS4X 5880.0
EIF3E 5539.0
RPS23 5172.0
RPS3 5117.0
RPS18 5100.0
RPS20 5062.0
RPS5 4999.0
EIF2S1 4996.0
RPS8 4889.0
RPS13 4582.0
RPS19 4331.0
EIF3M 4156.0
RPS6 4076.0
EIF2S2 3887.0
RPS9 3818.0
EIF3H 3301.0
RPS21 3125.0
RPS11 3037.0
RPS16 2931.0
RPS15 2680.0
RPS14 2662.0
EIF3F 2512.0
FAU 2504.0
RPS26 2036.0
RPS27A 2027.0
EIF3G 675.0
EIF3I 488.0
EIF3K -23.0
RPS29 -668.0
EIF3A -942.0
EIF3D -1521.0
EIF3B -2568.0
EIF3C -3429.5
EIF3L -4005.0


Synthesis of PE

Synthesis of PE
1147
set Synthesis of PE
setSize 11
pANOVA 0.0131
s.dist -0.432
p.adjustANOVA 0.0834



Top enriched genes

Top 20 genes
GeneID Gene Rank
LPIN1 -6414.0
PCYT2 -6112.0
PHOSPHO1 -5980.0
LPIN2 -4562.0
PISD -4297.0
LPIN3 -2291.0
ETNK2 -2088.0
ETNK1 -1213.0
CHKB -1185.5
CHKA -970.0
CEPT1 5562.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LPIN1 -6414.0
PCYT2 -6112.0
PHOSPHO1 -5980.0
LPIN2 -4562.0
PISD -4297.0
LPIN3 -2291.0
ETNK2 -2088.0
ETNK1 -1213.0
CHKB -1185.5
CHKA -970.0
CEPT1 5562.0


Glycogen storage diseases

Glycogen storage diseases
449
set Glycogen storage diseases
setSize 11
pANOVA 0.0136
s.dist -0.43
p.adjustANOVA 0.0854



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -6404
GYS1 -6290
PPP1R3C -5637
GAA -5242
G6PC3 -4922
NHLRC1 -3330
GBE1 -2001
EPM2A -1087
GYG1 637
RPS27A 2027
SLC37A4 2876

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -6404
GYS1 -6290
PPP1R3C -5637
GAA -5242
G6PC3 -4922
NHLRC1 -3330
GBE1 -2001
EPM2A -1087
GYG1 637
RPS27A 2027
SLC37A4 2876


Interleukin-12 signaling

Interleukin-12 signaling
540
set Interleukin-12 signaling
setSize 35
pANOVA 1.31e-05
s.dist 0.426
p.adjustANOVA 0.000279



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAP1B 6480.0
VAMP7 6230.0
PPIA 6072.0
GSTA2 5867.5
PDCD4 5835.0
CDC42 5339.0
SNRPA1 5209.0
ANXA2 5133.0
LCP1 5065.0
PITPNA 4954.0
HNRNPF 4847.0
HSPA9 4673.0
STAT4 4147.0
PAK2 3941.0
TCP1 3864.0
HNRNPA2B1 3762.0
PSME2 3632.0
JAK2 3607.0
MSN 3127.0
LMNB1 3110.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAP1B 6480.0
VAMP7 6230.0
PPIA 6072.0
GSTA2 5867.5
PDCD4 5835.0
CDC42 5339.0
SNRPA1 5209.0
ANXA2 5133.0
LCP1 5065.0
PITPNA 4954.0
HNRNPF 4847.0
HSPA9 4673.0
STAT4 4147.0
PAK2 3941.0
TCP1 3864.0
HNRNPA2B1 3762.0
PSME2 3632.0
JAK2 3607.0
MSN 3127.0
LMNB1 3110.0
CFL1 2998.0
RALA 2628.0
TYK2 2564.0
SOD1 2540.0
MTAP 2054.5
JAK1 1996.0
BOLA2 929.5
P4HB 882.0
ARF1 843.0
AIP 732.0
MIF 561.0
CNN2 -799.0
TALDO1 -1596.0
SOD2 -2765.0
GSTO1 -5235.0


Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
430
set Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
setSize 30
pANOVA 6.11e-05
s.dist 0.423
p.adjustANOVA 0.00109



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAP1B 6480.0
PPIA 6072.0
GSTA2 5867.5
PDCD4 5835.0
CDC42 5339.0
SNRPA1 5209.0
ANXA2 5133.0
LCP1 5065.0
PITPNA 4954.0
HNRNPF 4847.0
HSPA9 4673.0
STAT4 4147.0
PAK2 3941.0
TCP1 3864.0
HNRNPA2B1 3762.0
PSME2 3632.0
MSN 3127.0
LMNB1 3110.0
CFL1 2998.0
RALA 2628.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAP1B 6480.0
PPIA 6072.0
GSTA2 5867.5
PDCD4 5835.0
CDC42 5339.0
SNRPA1 5209.0
ANXA2 5133.0
LCP1 5065.0
PITPNA 4954.0
HNRNPF 4847.0
HSPA9 4673.0
STAT4 4147.0
PAK2 3941.0
TCP1 3864.0
HNRNPA2B1 3762.0
PSME2 3632.0
MSN 3127.0
LMNB1 3110.0
CFL1 2998.0
RALA 2628.0
SOD1 2540.0
MTAP 2054.5
BOLA2 929.5
ARF1 843.0
AIP 732.0
MIF 561.0
CNN2 -799.0
TALDO1 -1596.0
SOD2 -2765.0
GSTO1 -5235.0


NCAM1 interactions

NCAM1 interactions
677
set NCAM1 interactions
setSize 29
pANOVA 9.65e-05
s.dist -0.418
p.adjustANOVA 0.00154



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRNP -6350
COL4A2 -6166
COL4A1 -6153
COL4A3 -6151
COL4A4 -5975
CACNB1 -5659
COL6A3 -5552
CACNA1H -5403
CACNA1D -5368
COL6A6 -5131
COL6A2 -4669
CACNA1C -4631
NRTN -4489
COL4A5 -4162
COL6A1 -3959
CACNA1S -3639
CNTN2 -3016
GFRA4 -1418
CACNB4 -1238
GFRA1 -1121

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRNP -6350
COL4A2 -6166
COL4A1 -6153
COL4A3 -6151
COL4A4 -5975
CACNB1 -5659
COL6A3 -5552
CACNA1H -5403
CACNA1D -5368
COL6A6 -5131
COL6A2 -4669
CACNA1C -4631
NRTN -4489
COL4A5 -4162
COL6A1 -3959
CACNA1S -3639
CNTN2 -3016
GFRA4 -1418
CACNB4 -1238
GFRA1 -1121
AGRN -1106
CACNB3 -82
CACNA1G 316
ST8SIA2 1001
NCAM1 1697
NCAN 1786
ST8SIA4 2324
GFRA2 2522
CACNB2 6616


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] fgsea_1.14.0                gplots_3.0.3               
##  [9] DESeq2_1.28.1               SummarizedExperiment_1.18.1
## [11] DelayedArray_0.14.0         matrixStats_0.56.0         
## [13] Biobase_2.48.0              GenomicRanges_1.40.0       
## [15] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [17] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [19] reshape2_1.4.4              forcats_0.5.0              
## [21] stringr_1.4.0               dplyr_1.0.0                
## [23] purrr_0.3.4                 readr_1.3.1                
## [25] tidyr_1.1.0                 tibble_3.0.1               
## [27] ggplot2_3.3.2               tidyverse_1.3.0            
## [29] locfit_1.5-9.4              statmod_1.4.34             
## [31] plyr_1.8.6                 
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] MASS_7.3-51.6          scales_1.1.1           hms_0.5.3             
## [49] promises_1.1.1         RColorBrewer_1.1-2     yaml_2.2.1            
## [52] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
## [55] stringi_1.4.6          RSQLite_2.2.0          highr_0.8             
## [58] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
## [61] BiocParallel_1.22.0    rlang_0.4.6            pkgconfig_2.0.3       
## [64] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
## [67] htmlwidgets_1.5.1      bit_1.1-15.2           tidyselect_1.1.0      
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          grid_4.0.2             readxl_1.3.1          
## [85] data.table_1.12.8      blob_1.2.1             reprex_0.3.0          
## [88] digest_0.6.25          pbmcapply_1.5.0        xtable_1.8-4          
## [91] httpuv_1.5.4           munsell_0.5.0

END of report