Mitch Report

date generated: 2020-07-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## A2M    -0.27091788
## A4GALT  1.99263712
## AAAS    1.07279989
## AACS   -0.00214706
## AAED1  -1.15426628
## AAGAB  -0.96778649

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2400
num_genes_in_profile	13088
duplicated_genes_present	0
num_profile_genes_in_sets	7450
num_profile_genes_not_in_sets	5638

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1065
num_genesets_included	1335

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Unwinding of DNA	12	2.24e-05	0.707	5.65e-04
Classical antibody-mediated complement activation	10	1.73e-04	0.686	2.99e-03
Phosphorylation of CD3 and TCR zeta chains	11	2.85e-04	0.632	4.65e-03
Interferon alpha/beta signaling	45	5.91e-13	0.620	1.97e-10
Initial triggering of complement	19	3.48e-06	0.615	1.11e-04
LGI-ADAM interactions	11	5.43e-04	-0.602	7.34e-03
Creation of C4 and C2 activators	12	4.39e-04	0.586	6.27e-03
Peptide chain elongation	55	1.57e-13	0.575	9.73e-11
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	11	1.19e-03	-0.565	1.38e-02
Selenocysteine synthesis	58	2.19e-13	0.557	9.73e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency	65	1.04e-14	0.555	1.39e-11
Viral mRNA Translation	55	2.13e-12	0.548	5.69e-10
Condensation of Prometaphase Chromosomes	11	1.85e-03	0.542	1.79e-02
DNA strand elongation	32	1.25e-07	0.540	4.87e-06
Glucuronidation	11	2.69e-03	0.523	2.24e-02
PI-3K cascade:FGFR2	14	7.59e-04	-0.520	9.29e-03
Eukaryotic Translation Elongation	59	5.35e-12	0.519	1.02e-09
PI-3K cascade:FGFR4	11	2.92e-03	-0.518	2.39e-02
Processive synthesis on the lagging strand	15	6.15e-04	0.511	8.21e-03
Glycogen storage diseases	11	3.45e-03	-0.509	2.73e-02
Eukaryotic Translation Termination	58	2.10e-11	0.509	2.55e-09
FCGR activation	16	4.38e-04	0.508	6.27e-03
Cholesterol biosynthesis	23	2.98e-05	-0.503	6.85e-04
Signaling by Activin	11	4.50e-03	-0.495	3.21e-02
Regulation of IFNA signaling	12	3.69e-03	0.484	2.85e-02
Activation of the pre-replicative complex	31	3.20e-06	0.483	1.04e-04
Removal of the Flap Intermediate	14	1.74e-03	0.483	1.73e-02
Formation of a pool of free 40S subunits	65	5.29e-11	0.471	5.43e-09
Generation of second messenger molecules	22	1.50e-04	0.467	2.71e-03
PD-1 signaling	10	1.13e-02	0.463	6.03e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	60	7.23e-10	0.460	4.83e-08
Selenoamino acid metabolism	71	3.03e-11	0.456	3.37e-09
HSF1-dependent transactivation	32	8.51e-06	-0.455	2.32e-04
FRS-mediated FGFR2 signaling	16	1.66e-03	-0.454	1.68e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	6.57e-03	0.453	4.22e-02
SRP-dependent cotranslational protein targeting to membrane	76	1.61e-11	0.447	2.27e-09
G1/S-Specific Transcription	26	8.73e-05	0.445	1.77e-03
Activated NTRK2 signals through FRS2 and FRS3	10	1.61e-02	-0.440	8.10e-02
Lagging Strand Synthesis	20	6.83e-04	0.439	8.60e-03
Activation of AMPK downstream of NMDARs	10	1.63e-02	-0.439	8.18e-02
Removal of the Flap Intermediate from the C-strand	17	1.75e-03	0.438	1.73e-02
STING mediated induction of host immune responses	12	8.54e-03	0.438	4.96e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	4.54e-03	0.438	3.22e-02
FRS-mediated FGFR4 signaling	13	6.28e-03	-0.438	4.11e-02
G0 and Early G1	25	1.64e-04	0.435	2.89e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	75	9.63e-11	0.432	9.18e-09
Antimicrobial peptides	13	7.07e-03	0.432	4.40e-02
L13a-mediated translational silencing of Ceruloplasmin expression	73	1.88e-10	0.431	1.48e-08
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	5.44e-03	0.429	3.70e-02
Condensation of Prophase Chromosomes	13	7.43e-03	0.429	4.47e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Unwinding of DNA	12	2.24e-05	0.707000	5.65e-04
Classical antibody-mediated complement activation	10	1.73e-04	0.686000	2.99e-03
Phosphorylation of CD3 and TCR zeta chains	11	2.85e-04	0.632000	4.65e-03
Interferon alpha/beta signaling	45	5.91e-13	0.620000	1.97e-10
Initial triggering of complement	19	3.48e-06	0.615000	1.11e-04
LGI-ADAM interactions	11	5.43e-04	-0.602000	7.34e-03
Creation of C4 and C2 activators	12	4.39e-04	0.586000	6.27e-03
Peptide chain elongation	55	1.57e-13	0.575000	9.73e-11
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	11	1.19e-03	-0.565000	1.38e-02
Selenocysteine synthesis	58	2.19e-13	0.557000	9.73e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency	65	1.04e-14	0.555000	1.39e-11
Viral mRNA Translation	55	2.13e-12	0.548000	5.69e-10
Condensation of Prometaphase Chromosomes	11	1.85e-03	0.542000	1.79e-02
DNA strand elongation	32	1.25e-07	0.540000	4.87e-06
Glucuronidation	11	2.69e-03	0.523000	2.24e-02
PI-3K cascade:FGFR2	14	7.59e-04	-0.520000	9.29e-03
Eukaryotic Translation Elongation	59	5.35e-12	0.519000	1.02e-09
PI-3K cascade:FGFR4	11	2.92e-03	-0.518000	2.39e-02
Processive synthesis on the lagging strand	15	6.15e-04	0.511000	8.21e-03
Glycogen storage diseases	11	3.45e-03	-0.509000	2.73e-02
Eukaryotic Translation Termination	58	2.10e-11	0.509000	2.55e-09
FCGR activation	16	4.38e-04	0.508000	6.27e-03
Cholesterol biosynthesis	23	2.98e-05	-0.503000	6.85e-04
Signaling by Activin	11	4.50e-03	-0.495000	3.21e-02
Regulation of IFNA signaling	12	3.69e-03	0.484000	2.85e-02
Activation of the pre-replicative complex	31	3.20e-06	0.483000	1.04e-04
Removal of the Flap Intermediate	14	1.74e-03	0.483000	1.73e-02
Formation of a pool of free 40S subunits	65	5.29e-11	0.471000	5.43e-09
Generation of second messenger molecules	22	1.50e-04	0.467000	2.71e-03
PD-1 signaling	10	1.13e-02	0.463000	6.03e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	60	7.23e-10	0.460000	4.83e-08
Selenoamino acid metabolism	71	3.03e-11	0.456000	3.37e-09
HSF1-dependent transactivation	32	8.51e-06	-0.455000	2.32e-04
FRS-mediated FGFR2 signaling	16	1.66e-03	-0.454000	1.68e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	6.57e-03	0.453000	4.22e-02
SRP-dependent cotranslational protein targeting to membrane	76	1.61e-11	0.447000	2.27e-09
G1/S-Specific Transcription	26	8.73e-05	0.445000	1.77e-03
Activated NTRK2 signals through FRS2 and FRS3	10	1.61e-02	-0.440000	8.10e-02
Lagging Strand Synthesis	20	6.83e-04	0.439000	8.60e-03
Activation of AMPK downstream of NMDARs	10	1.63e-02	-0.439000	8.18e-02
Removal of the Flap Intermediate from the C-strand	17	1.75e-03	0.438000	1.73e-02
STING mediated induction of host immune responses	12	8.54e-03	0.438000	4.96e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	4.54e-03	0.438000	3.22e-02
FRS-mediated FGFR4 signaling	13	6.28e-03	-0.438000	4.11e-02
G0 and Early G1	25	1.64e-04	0.435000	2.89e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	75	9.63e-11	0.432000	9.18e-09
Antimicrobial peptides	13	7.07e-03	0.432000	4.40e-02
L13a-mediated translational silencing of Ceruloplasmin expression	73	1.88e-10	0.431000	1.48e-08
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	5.44e-03	0.429000	3.70e-02
Condensation of Prophase Chromosomes	13	7.43e-03	0.429000	4.47e-02
Processive synthesis on the C-strand of the telomere	19	1.52e-03	0.420000	1.62e-02
IRF3-mediated induction of type I IFN	10	2.26e-02	0.416000	1.03e-01
Activation of ATR in response to replication stress	35	2.52e-05	0.412000	6.24e-04
Cap-dependent Translation Initiation	81	2.10e-10	0.409000	1.48e-08
Eukaryotic Translation Initiation	81	2.10e-10	0.409000	1.48e-08
PCNA-Dependent Long Patch Base Excision Repair	21	1.19e-03	0.408000	1.38e-02
Signaling by Leptin	10	2.53e-02	-0.408000	1.12e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	50	6.15e-07	0.408000	2.22e-05
Transcription of E2F targets under negative control by DREAM complex	18	2.79e-03	0.407000	2.30e-02
Termination of translesion DNA synthesis	29	1.49e-04	0.407000	2.71e-03
Formation of the ternary complex, and subsequently, the 43S complex	39	1.14e-05	0.406000	3.06e-04
HDMs demethylate histones	21	1.31e-03	-0.405000	1.46e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	6.71e-03	0.404000	4.25e-02
Leading Strand Synthesis	14	9.79e-03	0.399000	5.45e-02
Polymerase switching	14	9.79e-03	0.399000	5.45e-02
PI-3K cascade:FGFR3	12	1.72e-02	-0.397000	8.43e-02
Polo-like kinase mediated events	15	8.15e-03	0.395000	4.79e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	80	1.50e-09	0.391000	9.12e-08
Nonsense-Mediated Decay (NMD)	80	1.50e-09	0.391000	9.12e-08
P2Y receptors	10	3.42e-02	0.387000	1.31e-01
Mismatch Repair	15	1.01e-02	0.384000	5.56e-02
Negative regulation of FGFR2 signaling	23	1.51e-03	-0.382000	1.62e-02
Attenuation phase	22	2.25e-03	-0.376000	2.01e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	17	7.78e-03	-0.373000	4.63e-02
PKA activation in glucagon signalling	16	1.02e-02	-0.371000	5.57e-02
Prolactin receptor signaling	11	3.48e-02	-0.368000	1.31e-01
activated TAK1 mediates p38 MAPK activation	18	7.08e-03	-0.367000	4.40e-02
CD28 dependent Vav1 pathway	12	2.85e-02	0.365000	1.18e-01
Signaling by WNT in cancer	28	8.31e-04	-0.365000	1.01e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	46	1.89e-05	0.365000	4.86e-04
Miscellaneous transport and binding events	19	6.02e-03	-0.364000	4.00e-02
Defects in cobalamin (B12) metabolism	11	3.67e-02	-0.364000	1.37e-01
Telomere C-strand synthesis initiation	12	2.99e-02	0.362000	1.21e-01
Orc1 removal from chromatin	63	6.87e-07	0.362000	2.41e-05
Negative regulation of FGFR4 signaling	20	5.26e-03	-0.361000	3.64e-02
EGFR downregulation	26	1.53e-03	-0.359000	1.62e-02
G1/S Transition	119	1.40e-11	0.359000	2.27e-09
Polymerase switching on the C-strand of the telomere	25	1.95e-03	0.358000	1.85e-02
Ribosomal scanning and start codon recognition	46	2.71e-05	0.358000	6.59e-04
Regulation of expression of SLITs and ROBOs	120	1.70e-11	0.356000	2.27e-09
Gap-filling DNA repair synthesis and ligation in GG-NER	23	3.13e-03	0.356000	2.50e-02
DNA Replication Pre-Initiation	77	6.84e-08	0.356000	2.77e-06
Telomere C-strand (Lagging Strand) Synthesis	33	4.17e-04	0.355000	6.27e-03
DAP12 signaling	26	1.80e-03	0.354000	1.76e-02
Translation initiation complex formation	45	4.71e-05	0.351000	1.05e-03
PKA activation	17	1.24e-02	-0.351000	6.45e-02
Mitotic Telophase/Cytokinesis	12	3.58e-02	0.350000	1.34e-01
Establishment of Sister Chromatid Cohesion	10	5.65e-02	0.348000	1.80e-01
Mitotic G1 phase and G1/S transition	135	3.04e-12	0.348000	6.76e-10
Energy dependent regulation of mTOR by LKB1-AMPK	29	1.23e-03	-0.347000	1.39e-02
Synthesis of IP2, IP, and Ins in the cytosol	13	3.08e-02	-0.346000	1.23e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	2.13e-02	-0.343000	9.79e-02
Uptake and function of anthrax toxins	11	5.02e-02	-0.341000	1.68e-01
FRS-mediated FGFR3 signaling	14	2.78e-02	-0.340000	1.18e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	30	1.29e-03	0.340000	1.45e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	7.29e-03	-0.338000	4.45e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	20	9.03e-03	-0.337000	5.15e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	5.32e-02	0.337000	1.73e-01
Listeria monocytogenes entry into host cells	17	1.64e-02	-0.336000	8.21e-02
Cleavage of the damaged purine	11	5.40e-02	0.336000	1.74e-01
Depurination	11	5.40e-02	0.336000	1.74e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	5.40e-02	0.336000	1.74e-01
SCF(Skp2)-mediated degradation of p27/p21	52	2.93e-05	0.335000	6.85e-04
Assembly of the pre-replicative complex	61	6.55e-06	0.334000	1.94e-04
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	13	3.76e-02	-0.333000	1.38e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	13	3.76e-02	-0.333000	1.38e-01
Regulation of Complement cascade	32	1.11e-03	0.333000	1.31e-02
Diseases associated with N-glycosylation of proteins	16	2.12e-02	-0.333000	9.79e-02
Signaling by BMP	21	8.43e-03	-0.332000	4.93e-02
Physiological factors	11	5.68e-02	-0.332000	1.80e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	5.80e-02	-0.330000	1.83e-01
PECAM1 interactions	11	5.92e-02	0.329000	1.84e-01
Blood group systems biosynthesis	12	4.91e-02	-0.328000	1.67e-01
Activation of gene expression by SREBF (SREBP)	41	2.97e-04	-0.327000	4.73e-03
PI-3K cascade:FGFR1	12	5.02e-02	-0.327000	1.68e-01
RIPK1-mediated regulated necrosis	14	3.46e-02	0.326000	1.31e-01
Regulated Necrosis	14	3.46e-02	0.326000	1.31e-01
Interferon gamma signaling	64	6.99e-06	0.325000	1.98e-04
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	11	6.31e-02	0.324000	1.94e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	6.34e-03	0.322000	4.11e-02
TRAF3-dependent IRF activation pathway	13	4.45e-02	0.322000	1.57e-01
GPVI-mediated activation cascade	30	2.31e-03	0.322000	2.04e-02
Termination of O-glycan biosynthesis	10	7.85e-02	-0.321000	2.27e-01
Cleavage of the damaged pyrimidine	16	2.61e-02	0.321000	1.13e-01
Depyrimidination	16	2.61e-02	0.321000	1.13e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	2.61e-02	0.321000	1.13e-01
Cytosolic sulfonation of small molecules	15	3.13e-02	0.321000	1.24e-01
TRAF6 mediated IRF7 activation	15	3.22e-02	0.320000	1.26e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	12	5.63e-02	-0.318000	1.80e-01
Lewis blood group biosynthesis	10	8.18e-02	-0.318000	2.34e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	8.26e-02	-0.317000	2.35e-01
InlB-mediated entry of Listeria monocytogenes into host cell	13	4.80e-02	-0.317000	1.66e-01
Extension of Telomeres	48	1.50e-04	0.316000	2.71e-03
Pyruvate metabolism	26	5.41e-03	-0.315000	3.70e-02
Downstream signaling of activated FGFR2	21	1.25e-02	-0.315000	6.49e-02
Regulation of necroptotic cell death	12	5.91e-02	0.315000	1.84e-01
SHC-mediated cascade:FGFR2	14	4.16e-02	-0.315000	1.48e-01
Pyrimidine salvage	10	8.63e-02	0.313000	2.40e-01
Signaling by NODAL	13	5.09e-02	-0.313000	1.70e-01
Biosynthesis of specialized proresolving mediators (SPMs)	13	5.12e-02	0.312000	1.70e-01
Regulation of FZD by ubiquitination	13	5.20e-02	-0.311000	1.71e-01
DAP12 interactions	29	3.77e-03	0.311000	2.88e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	7.43e-02	0.311000	2.18e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	5.38e-02	0.309000	1.74e-01
PKA-mediated phosphorylation of CREB	19	2.01e-02	-0.308000	9.50e-02
G2/M Checkpoints	124	4.18e-09	0.306000	2.33e-07
Synthesis of DNA	112	2.38e-08	0.306000	1.03e-06
Cyclin E associated events during G1/S transition	75	4.93e-06	0.305000	1.50e-04
Cross-presentation of soluble exogenous antigens (endosomes)	45	4.00e-04	0.305000	6.14e-03
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	1.09e-04	-0.305000	2.18e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	35	1.86e-03	0.304000	1.79e-02
CASP8 activity is inhibited	10	9.63e-02	0.304000	2.56e-01
Dimerization of procaspase-8	10	9.63e-02	0.304000	2.56e-01
Regulation by c-FLIP	10	9.63e-02	0.304000	2.56e-01
Cyclin A:Cdk2-associated events at S phase entry	77	4.17e-06	0.304000	1.29e-04
EPHA-mediated growth cone collapse	14	4.94e-02	0.303000	1.67e-01
Misspliced GSK3beta mutants stabilize beta-catenin	14	4.95e-02	-0.303000	1.67e-01
S33 mutants of beta-catenin aren't phosphorylated	14	4.95e-02	-0.303000	1.67e-01
S37 mutants of beta-catenin aren't phosphorylated	14	4.95e-02	-0.303000	1.67e-01
S45 mutants of beta-catenin aren't phosphorylated	14	4.95e-02	-0.303000	1.67e-01
T41 mutants of beta-catenin aren't phosphorylated	14	4.95e-02	-0.303000	1.67e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	14	4.95e-02	-0.303000	1.67e-01
DNA Replication	119	1.27e-08	0.302000	6.16e-07
Base Excision Repair	45	4.52e-04	0.302000	6.29e-03
Ion homeostasis	43	6.73e-04	-0.300000	8.60e-03
S Phase	152	2.06e-10	0.299000	1.48e-08
Negative regulation of FGFR3 signaling	21	1.78e-02	-0.299000	8.57e-02
Regulation of innate immune responses to cytosolic DNA	11	8.70e-02	0.298000	2.40e-01
FGFR2 mutant receptor activation	23	1.39e-02	-0.296000	7.10e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	1.05e-01	-0.296000	2.71e-01
Complement cascade	36	2.16e-03	0.295000	1.95e-02
Cyclin A/B1/B2 associated events during G2/M transition	22	1.76e-02	0.293000	8.52e-02
Metabolism of polyamines	53	2.34e-04	0.292000	3.91e-03
Base-Excision Repair, AP Site Formation	18	3.25e-02	0.291000	1.27e-01
Defects in vitamin and cofactor metabolism	19	2.83e-02	-0.291000	1.18e-01
Negative regulation of NOTCH4 signaling	48	5.01e-04	0.291000	6.89e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	46	6.82e-04	0.290000	8.60e-03
p53-Independent DNA Damage Response	46	6.82e-04	0.290000	8.60e-03
p53-Independent G1/S DNA damage checkpoint	46	6.82e-04	0.290000	8.60e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	1.08e-02	-0.289000	5.88e-02
Resolution of Abasic Sites (AP sites)	37	2.45e-03	0.288000	2.11e-02
RHO GTPases Activate NADPH Oxidases	19	3.02e-02	0.287000	1.21e-01
Zinc transporters	13	7.33e-02	0.287000	2.15e-01
Antigen processing-Cross presentation	83	6.74e-06	0.286000	1.95e-04
Activation of the AP-1 family of transcription factors	10	1.18e-01	-0.286000	2.90e-01
Nephrin family interactions	19	3.12e-02	0.286000	1.24e-01
MECP2 regulates neuronal receptors and channels	12	8.69e-02	0.285000	2.40e-01
Inflammasomes	19	3.15e-02	0.285000	1.24e-01
ATF4 activates genes in response to endoplasmic reticulum stress	24	1.58e-02	0.285000	7.97e-02
Glycogen synthesis	12	8.78e-02	-0.285000	2.40e-01
Interleukin-12 signaling	35	3.59e-03	0.285000	2.79e-02
Nicotinamide salvaging	13	7.81e-02	0.282000	2.26e-01
Calnexin/calreticulin cycle	23	1.99e-02	-0.281000	9.41e-02
Downstream signaling of activated FGFR4	18	3.99e-02	-0.280000	1.44e-01
FRS-mediated FGFR1 signaling	14	7.05e-02	-0.279000	2.09e-01
Recognition of DNA damage by PCNA-containing replication complex	28	1.11e-02	0.277000	5.99e-02
rRNA processing in the nucleus and cytosol	150	5.85e-09	0.276000	3.00e-07
Prolonged ERK activation events	13	8.57e-02	-0.275000	2.40e-01
Presynaptic depolarization and calcium channel opening	11	1.15e-01	-0.275000	2.87e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	44	1.65e-03	0.274000	1.68e-02
AMER1 mutants destabilize the destruction complex	13	8.74e-02	-0.274000	2.40e-01
APC truncation mutants have impaired AXIN binding	13	8.74e-02	-0.274000	2.40e-01
AXIN missense mutants destabilize the destruction complex	13	8.74e-02	-0.274000	2.40e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	13	8.74e-02	-0.274000	2.40e-01
Truncations of AMER1 destabilize the destruction complex	13	8.74e-02	-0.274000	2.40e-01
truncated APC mutants destabilize the destruction complex	13	8.74e-02	-0.274000	2.40e-01
CDT1 association with the CDC6:ORC:origin complex	52	6.62e-04	0.273000	8.60e-03
Ubiquitin-dependent degradation of Cyclin D	46	1.39e-03	0.273000	1.52e-02
Translesion synthesis by POLK	15	6.85e-02	0.272000	2.06e-01
CaM pathway	33	7.37e-03	-0.270000	4.45e-02
Calmodulin induced events	33	7.37e-03	-0.270000	4.45e-02
Regulation of TP53 Activity through Association with Co-factors	12	1.08e-01	-0.268000	2.73e-01
ER-Phagosome pathway	69	1.18e-04	0.268000	2.28e-03
Signaling by Hippo	19	4.37e-02	-0.267000	1.54e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	14	8.35e-02	0.267000	2.37e-01
Telomere Maintenance	62	2.86e-04	0.267000	4.65e-03
Transcriptional regulation of pluripotent stem cells	16	6.49e-02	-0.267000	1.98e-01
DNA Damage Bypass	44	2.26e-03	0.266000	2.01e-02
Telomere Extension By Telomerase	21	3.49e-02	0.266000	1.32e-01
Fertilization	10	1.47e-01	0.265000	3.37e-01
Ca-dependent events	35	6.92e-03	-0.264000	4.36e-02
Major pathway of rRNA processing in the nucleolus and cytosol	141	6.85e-08	0.264000	2.77e-06
FCGR3A-mediated phagocytosis	61	4.42e-04	0.260000	6.27e-03
Leishmania phagocytosis	61	4.42e-04	0.260000	6.27e-03
Parasite infection	61	4.42e-04	0.260000	6.27e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	1.55e-01	0.260000	3.49e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	7.04e-03	-0.260000	4.40e-02
Vif-mediated degradation of APOBEC3G	45	2.64e-03	0.259000	2.24e-02
Signaling by FGFR2 IIIa TM	18	5.72e-02	-0.259000	1.81e-01
Chromosome Maintenance	82	5.20e-05	0.259000	1.12e-03
Negative regulation of FGFR1 signaling	21	4.04e-02	-0.258000	1.45e-01
Role of phospholipids in phagocytosis	27	2.06e-02	0.258000	9.61e-02
SHC-mediated cascade:FGFR4	11	1.40e-01	-0.257000	3.24e-01
NCAM1 interactions	29	1.70e-02	-0.256000	8.37e-02
Signaling by FGFR2 in disease	33	1.11e-02	-0.256000	5.99e-02
rRNA processing	167	1.38e-08	0.255000	6.16e-07
Vpu mediated degradation of CD4	46	2.79e-03	0.255000	2.30e-02
The role of Nef in HIV-1 replication and disease pathogenesis	25	2.81e-02	0.254000	1.18e-01
Spry regulation of FGF signaling	14	1.01e-01	-0.253000	2.63e-01
Translesion synthesis by POLI	15	8.97e-02	0.253000	2.43e-01
Frs2-mediated activation	11	1.47e-01	-0.252000	3.37e-01
Nucleotide-like (purinergic) receptors	13	1.15e-01	0.252000	2.87e-01
Selective autophagy	53	1.51e-03	-0.252000	1.62e-02
CDC6 association with the ORC:origin complex	10	1.68e-01	0.252000	3.69e-01
Meiotic synapsis	27	2.37e-02	0.252000	1.05e-01
Transcriptional regulation of granulopoiesis	26	2.64e-02	0.252000	1.14e-01
Switching of origins to a post-replicative state	83	7.56e-05	0.252000	1.58e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	49	2.39e-03	0.251000	2.10e-02
Defective CFTR causes cystic fibrosis	52	1.76e-03	0.251000	1.73e-02
Arachidonic acid metabolism	36	9.33e-03	0.251000	5.30e-02
MTOR signalling	40	6.32e-03	-0.250000	4.11e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	9.55e-02	-0.249000	2.55e-01
SCF-beta-TrCP mediated degradation of Emi1	49	2.63e-03	0.249000	2.24e-02
Negative regulation of MET activity	19	6.09e-02	-0.248000	1.88e-01
PLC beta mediated events	49	2.69e-03	-0.248000	2.24e-02
Influenza Viral RNA Transcription and Replication	96	2.88e-05	0.247000	6.85e-04
Free fatty acids regulate insulin secretion	10	1.78e-01	-0.246000	3.83e-01
NGF-stimulated transcription	34	1.33e-02	-0.245000	6.87e-02
Translesion synthesis by REV1	14	1.12e-01	0.245000	2.82e-01
Glycogen metabolism	23	4.19e-02	-0.245000	1.49e-01
Nucleotide salvage	21	5.21e-02	0.245000	1.71e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	54	1.90e-03	0.244000	1.81e-02
RET signaling	35	1.26e-02	-0.244000	6.54e-02
DAG and IP3 signaling	39	8.50e-03	-0.244000	4.95e-02
Autodegradation of the E3 ubiquitin ligase COP1	46	4.44e-03	0.243000	3.19e-02
Smooth Muscle Contraction	36	1.21e-02	0.242000	6.34e-02
G1/S DNA Damage Checkpoints	60	1.23e-03	0.241000	1.39e-02
Signaling by ROBO receptors	162	1.28e-07	0.241000	4.87e-06
Regulation of MECP2 expression and activity	28	2.76e-02	-0.241000	1.18e-01
Purine salvage	12	1.50e-01	0.240000	3.41e-01
Uptake and actions of bacterial toxins	24	4.22e-02	-0.240000	1.49e-01
Stabilization of p53	50	3.50e-03	0.239000	2.75e-02
Common Pathway of Fibrin Clot Formation	10	1.93e-01	0.238000	4.01e-01
Regulation of ornithine decarboxylase (ODC)	46	5.31e-03	0.238000	3.65e-02
TCR signaling	99	4.85e-05	0.237000	1.06e-03
Cardiac conduction	100	4.66e-05	-0.236000	1.05e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.76e-01	-0.236000	3.79e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	50	3.93e-03	-0.236000	2.94e-02
Interleukin-12 family signaling	41	9.02e-03	0.236000	5.15e-02
Adenylate cyclase activating pathway	10	1.98e-01	-0.235000	4.07e-01
RHO GTPases activate PAKs	21	6.21e-02	0.235000	1.92e-01
Regulation of RAS by GAPs	60	1.71e-03	0.234000	1.71e-02
TRP channels	12	1.61e-01	0.234000	3.59e-01
HDR through Homologous Recombination (HRR)	61	1.66e-03	0.233000	1.68e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	89	1.48e-04	0.233000	2.71e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs	62	1.57e-03	0.232000	1.64e-02
Sulfur amino acid metabolism	21	6.59e-02	-0.232000	2.00e-01
TGF-beta receptor signaling activates SMADs	29	3.09e-02	-0.232000	1.23e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	31	2.58e-02	-0.231000	1.13e-01
Beta-catenin phosphorylation cascade	16	1.09e-01	-0.231000	2.77e-01
Cellular response to heat stress	87	1.97e-04	-0.231000	3.38e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	9.96e-02	0.231000	2.61e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	9.96e-02	0.231000	2.61e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	25	4.59e-02	-0.231000	1.61e-01
Interferon Signaling	146	1.57e-06	0.231000	5.24e-05
Regulation of TNFR1 signaling	27	3.81e-02	0.231000	1.39e-01
p53-Dependent G1 DNA Damage Response	58	2.42e-03	0.230000	2.10e-02
p53-Dependent G1/S DNA damage checkpoint	58	2.42e-03	0.230000	2.10e-02
Activation of BAD and translocation to mitochondria	14	1.38e-01	0.229000	3.20e-01
Receptor Mediated Mitophagy	11	1.91e-01	-0.228000	4.01e-01
Deposition of new CENPA-containing nucleosomes at the centromere	22	6.48e-02	0.227000	1.98e-01
Nucleosome assembly	22	6.48e-02	0.227000	1.98e-01
Signaling by FGFR4	30	3.12e-02	-0.227000	1.24e-01
Sialic acid metabolism	26	4.50e-02	-0.227000	1.58e-01
G-protein mediated events	50	5.53e-03	-0.227000	3.75e-02
Signaling by FGFR3 in disease	16	1.16e-01	-0.227000	2.88e-01
Signaling by FGFR3 point mutants in cancer	16	1.16e-01	-0.227000	2.88e-01
Biosynthesis of DHA-derived SPMs	11	1.95e-01	0.226000	4.04e-01
Mitochondrial Fatty Acid Beta-Oxidation	32	2.76e-02	0.225000	1.18e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	4.74e-02	-0.225000	1.65e-01
G2/M DNA damage checkpoint	58	3.13e-03	0.224000	2.50e-02
PERK regulates gene expression	28	3.99e-02	0.224000	1.44e-01
Crosslinking of collagen fibrils	10	2.20e-01	0.224000	4.33e-01
Metal ion SLC transporters	21	7.61e-02	0.224000	2.22e-01
Downregulation of TGF-beta receptor signaling	24	5.82e-02	-0.223000	1.84e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	48	7.57e-03	0.223000	4.53e-02
Membrane binding and targetting of GAG proteins	11	2.01e-01	-0.223000	4.10e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	11	2.01e-01	-0.223000	4.10e-01
Heme biosynthesis	13	1.65e-01	-0.223000	3.64e-01
Activation of Matrix Metalloproteinases	17	1.12e-01	-0.222000	2.83e-01
COPI-independent Golgi-to-ER retrograde traffic	30	3.56e-02	-0.222000	1.34e-01
Early Phase of HIV Life Cycle	13	1.68e-01	0.221000	3.69e-01
Maturation of nucleoprotein	10	2.29e-01	0.220000	4.47e-01
Chemokine receptors bind chemokines	31	3.53e-02	0.219000	1.33e-01
Other interleukin signaling	19	9.95e-02	0.218000	2.61e-01
EPHB-mediated forward signaling	32	3.28e-02	0.218000	1.27e-01
Regulation of RUNX3 expression and activity	48	9.42e-03	0.217000	5.30e-02
Metabolism of Angiotensinogen to Angiotensins	12	1.95e-01	-0.216000	4.04e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	11	2.15e-01	0.216000	4.28e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	18	1.13e-01	0.216000	2.83e-01
Downstream signaling of activated FGFR3	19	1.04e-01	-0.216000	2.67e-01
GRB2 events in EGFR signaling	10	2.38e-01	-0.215000	4.51e-01
E2F mediated regulation of DNA replication	20	9.72e-02	0.214000	2.57e-01
Hh mutants abrogate ligand secretion	50	8.89e-03	0.214000	5.14e-02
Acetylcholine regulates insulin secretion	10	2.42e-01	-0.214000	4.57e-01
HSF1 activation	24	7.07e-02	-0.213000	2.09e-01
Diseases of carbohydrate metabolism	27	5.53e-02	-0.213000	1.78e-01
IRE1alpha activates chaperones	49	1.01e-02	-0.212000	5.56e-02
Fcgamma receptor (FCGR) dependent phagocytosis	86	6.99e-04	0.212000	8.64e-03
Formation of Fibrin Clot (Clotting Cascade)	17	1.32e-01	0.211000	3.12e-01
AKT phosphorylates targets in the nucleus	10	2.48e-01	-0.211000	4.61e-01
Glucose metabolism	76	1.54e-03	-0.210000	1.62e-02
Processing of DNA double-strand break ends	58	5.69e-03	0.210000	3.83e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	32	3.98e-02	0.210000	1.44e-01
Asparagine N-linked glycosylation	249	1.34e-08	-0.210000	6.16e-07
Mitochondrial tRNA aminoacylation	18	1.24e-01	-0.209000	3.01e-01
Amine ligand-binding receptors	13	1.92e-01	-0.209000	4.01e-01
Regulation of actin dynamics for phagocytic cup formation	63	4.13e-03	0.209000	3.00e-02
COPII-mediated vesicle transport	59	5.75e-03	-0.208000	3.86e-02
ER Quality Control Compartment (ERQC)	18	1.27e-01	-0.208000	3.04e-01
Presynaptic phase of homologous DNA pairing and strand exchange	37	2.92e-02	0.207000	1.19e-01
PI3K events in ERBB2 signaling	14	1.80e-01	-0.207000	3.87e-01
Influenza Infection	112	1.58e-04	0.207000	2.82e-03
Degradation of DVL	50	1.15e-02	0.207000	6.16e-02
Hyaluronan uptake and degradation	11	2.36e-01	0.206000	4.51e-01
Regulation of Apoptosis	47	1.46e-02	0.206000	7.41e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	70	2.99e-03	0.205000	2.42e-02
Reproduction	57	8.00e-03	0.203000	4.74e-02
MAP kinase activation	60	6.71e-03	-0.203000	4.25e-02
Post NMDA receptor activation events	55	9.45e-03	-0.202000	5.30e-02
MyD88 cascade initiated on plasma membrane	78	2.06e-03	-0.202000	1.90e-02
Toll Like Receptor 10 (TLR10) Cascade	78	2.06e-03	-0.202000	1.90e-02
Toll Like Receptor 5 (TLR5) Cascade	78	2.06e-03	-0.202000	1.90e-02
Homology Directed Repair	95	6.94e-04	0.202000	8.64e-03
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	69	3.99e-03	-0.201000	2.94e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	69	3.99e-03	0.201000	2.94e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	67	4.62e-03	0.200000	3.23e-02
Prostacyclin signalling through prostacyclin receptor	15	1.80e-01	0.200000	3.87e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	48	1.69e-02	0.199000	8.34e-02
Regulation of PTEN mRNA translation	11	2.54e-01	-0.198000	4.71e-01
Integration of energy metabolism	91	1.11e-03	-0.198000	1.31e-02
Interleukin-17 signaling	64	6.19e-03	-0.198000	4.09e-02
Aquaporin-mediated transport	37	3.73e-02	-0.198000	1.38e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	1.71e-01	0.198000	3.72e-01
APC/C-mediated degradation of cell cycle proteins	81	2.14e-03	0.198000	1.95e-02
Regulation of mitotic cell cycle	81	2.14e-03	0.198000	1.95e-02
Transport of vitamins, nucleosides, and related molecules	29	6.62e-02	0.197000	2.01e-01
Branched-chain amino acid catabolism	21	1.19e-01	-0.197000	2.92e-01
Synthesis of PA	25	8.89e-02	-0.197000	2.42e-01
Macroautophagy	104	5.44e-04	-0.197000	7.34e-03
Transferrin endocytosis and recycling	24	9.67e-02	-0.196000	2.56e-01
Regulation of APC/C activators between G1/S and early anaphase	74	3.60e-03	0.196000	2.79e-02
TNFR1-induced proapoptotic signaling	13	2.22e-01	0.196000	4.36e-01
Adherens junctions interactions	14	2.05e-01	-0.196000	4.15e-01
Glycolysis	59	9.42e-03	-0.196000	5.30e-02
ATF6 (ATF6-alpha) activates chaperone genes	10	2.84e-01	-0.196000	4.96e-01
ER to Golgi Anterograde Transport	121	2.11e-04	-0.195000	3.56e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR)	34	4.90e-02	-0.195000	1.67e-01
Voltage gated Potassium channels	26	8.67e-02	-0.194000	2.40e-01
Signaling by NOTCH4	74	3.95e-03	0.194000	2.94e-02
Autophagy	116	3.23e-04	-0.194000	5.07e-03
PI3K Cascade	32	5.87e-02	-0.193000	1.84e-01
Phase 0 - rapid depolarisation	32	5.88e-02	-0.193000	1.84e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	57	1.21e-02	0.192000	6.34e-02
Assembly Of The HIV Virion	13	2.32e-01	-0.191000	4.50e-01
Signaling by EGFR in Cancer	20	1.38e-01	-0.191000	3.22e-01
Cyclin D associated events in G1	41	3.41e-02	0.191000	1.31e-01
G1 Phase	41	3.41e-02	0.191000	1.31e-01
The NLRP3 inflammasome	14	2.15e-01	0.191000	4.28e-01
RORA activates gene expression	17	1.72e-01	-0.191000	3.75e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	66	7.25e-03	0.191000	4.45e-02
Disorders of developmental biology	11	2.73e-01	-0.191000	4.90e-01
Loss of function of MECP2 in Rett syndrome	11	2.73e-01	-0.191000	4.90e-01
Pervasive developmental disorders	11	2.73e-01	-0.191000	4.90e-01
Meiosis	47	2.45e-02	0.190000	1.09e-01
Signaling by FGFR3	31	6.76e-02	-0.190000	2.04e-01
TNFR2 non-canonical NF-kB pathway	74	4.82e-03	0.190000	3.35e-02
Regulation of HSF1-mediated heat shock response	70	6.33e-03	-0.189000	4.11e-02
Respiratory electron transport	97	1.35e-03	0.189000	1.49e-02
RHO GTPases Activate WASPs and WAVEs	35	5.63e-02	0.187000	1.80e-01
Receptor-type tyrosine-protein phosphatases	14	2.27e-01	-0.186000	4.45e-01
Striated Muscle Contraction	29	8.26e-02	0.186000	2.35e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	103	1.12e-03	0.186000	1.31e-02
Transport to the Golgi and subsequent modification	146	1.11e-04	-0.186000	2.19e-03
Cell recruitment (pro-inflammatory response)	19	1.63e-01	0.185000	3.63e-01
Purinergic signaling in leishmaniasis infection	19	1.63e-01	0.185000	3.63e-01
Signaling by NTRKs	122	4.40e-04	-0.185000	6.27e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	10	3.15e-01	-0.184000	5.20e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	11	2.93e-01	0.183000	5.03e-01
CDK-mediated phosphorylation and removal of Cdc6	66	1.01e-02	0.183000	5.56e-02
Adenylate cyclase inhibitory pathway	14	2.36e-01	-0.183000	4.51e-01
XBP1(S) activates chaperone genes	47	3.01e-02	-0.183000	1.21e-01
Cell Cycle Checkpoints	235	1.48e-06	0.183000	5.07e-05
Nuclear Events (kinase and transcription factor activation)	56	1.80e-02	-0.183000	8.66e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	17	1.92e-01	-0.183000	4.01e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	17	1.92e-01	-0.183000	4.01e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	26	1.07e-01	-0.183000	2.73e-01
Trafficking of AMPA receptors	26	1.07e-01	-0.183000	2.73e-01
RHO GTPases activate CIT	19	1.69e-01	0.182000	3.71e-01
Degradation of AXIN	49	2.76e-02	0.182000	1.18e-01
TNFR1-induced NFkappaB signaling pathway	24	1.23e-01	0.182000	3.01e-01
ABC transporter disorders	62	1.36e-02	0.181000	7.00e-02
UCH proteinases	78	5.81e-03	0.181000	3.88e-02
G beta:gamma signalling through BTK	14	2.42e-01	0.181000	4.57e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	22	1.44e-01	-0.180000	3.31e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	12	2.81e-01	-0.180000	4.94e-01
Synaptic adhesion-like molecules	17	2.00e-01	-0.180000	4.09e-01
Homologous DNA Pairing and Strand Exchange	40	5.09e-02	0.178000	1.70e-01
Transport of bile salts and organic acids, metal ions and amine compounds	50	2.94e-02	0.178000	1.20e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.66e-01	-0.178000	4.86e-01
RNA Polymerase II Transcription Termination	61	1.65e-02	0.178000	8.23e-02
Assembly of active LPL and LIPC lipase complexes	11	3.08e-01	-0.177000	5.15e-01
Signaling by TGFB family members	87	4.32e-03	-0.177000	3.12e-02
Translation of structural proteins	26	1.18e-01	-0.177000	2.90e-01
Constitutive Signaling by EGFRvIII	15	2.36e-01	-0.177000	4.51e-01
Signaling by EGFRvIII in Cancer	15	2.36e-01	-0.177000	4.51e-01
NIK-->noncanonical NF-kB signaling	52	2.83e-02	0.176000	1.18e-01
Cell surface interactions at the vascular wall	98	2.66e-03	0.176000	2.24e-02
Insulin processing	21	1.63e-01	-0.176000	3.63e-01
Signaling by cytosolic FGFR1 fusion mutants	18	1.97e-01	-0.176000	4.06e-01
GRB2 events in ERBB2 signaling	14	2.56e-01	-0.175000	4.72e-01
Signaling by FGFR2	58	2.10e-02	-0.175000	9.74e-02
RAF-independent MAPK1/3 activation	21	1.65e-01	-0.175000	3.65e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	2.12e-01	0.175000	4.23e-01
mRNA 3'-end processing	52	3.03e-02	0.174000	1.22e-01
Regulation of beta-cell development	21	1.69e-01	-0.174000	3.70e-01
Gluconeogenesis	26	1.26e-01	-0.173000	3.04e-01
VLDLR internalisation and degradation	11	3.20e-01	0.173000	5.23e-01
Detoxification of Reactive Oxygen Species	30	1.01e-01	0.173000	2.63e-01
Myogenesis	23	1.51e-01	-0.173000	3.42e-01
MicroRNA (miRNA) biogenesis	23	1.51e-01	-0.173000	3.42e-01
Glyoxylate metabolism and glycine degradation	24	1.43e-01	-0.173000	3.30e-01
Inhibition of DNA recombination at telomere	20	1.81e-01	0.173000	3.88e-01
Transcriptional Regulation by E2F6	33	8.61e-02	0.173000	2.40e-01
ATF6 (ATF6-alpha) activates chaperones	12	3.03e-01	-0.172000	5.12e-01
Costimulation by the CD28 family	55	2.80e-02	0.171000	1.18e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	85	6.47e-03	-0.171000	4.17e-02
GLI3 is processed to GLI3R by the proteasome	52	3.30e-02	0.171000	1.28e-01
Regulation of KIT signaling	16	2.37e-01	0.171000	4.51e-01
Degradation of GLI1 by the proteasome	53	3.22e-02	0.170000	1.26e-01
Signaling by EGFR	45	4.89e-02	-0.170000	1.67e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	2.73e-01	0.169000	4.90e-01
Complex I biogenesis	54	3.19e-02	0.169000	1.25e-01
Degradation of GLI2 by the proteasome	52	3.60e-02	0.168000	1.34e-01
ERBB2 Activates PTK6 Signaling	10	3.58e-01	-0.168000	5.66e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	16	2.45e-01	-0.168000	4.60e-01
Regulated proteolysis of p75NTR	11	3.36e-01	-0.168000	5.43e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	9.18e-02	-0.167000	2.47e-01
Pentose phosphate pathway	13	2.97e-01	0.167000	5.07e-01
DCC mediated attractive signaling	13	2.98e-01	0.167000	5.07e-01
Transport of Ribonucleoproteins into the Host Nucleus	27	1.34e-01	-0.167000	3.15e-01
ABC transporters in lipid homeostasis	14	2.81e-01	-0.166000	4.94e-01
G beta:gamma signalling through PI3Kgamma	21	1.88e-01	0.166000	3.98e-01
Purine catabolism	17	2.37e-01	0.166000	4.51e-01
IRS-mediated signalling	36	8.61e-02	-0.165000	2.40e-01
ROS and RNS production in phagocytes	28	1.31e-01	0.165000	3.09e-01
Formation of the beta-catenin:TCF transactivating complex	29	1.24e-01	-0.165000	3.01e-01
Dectin-1 mediated noncanonical NF-kB signaling	53	3.80e-02	0.165000	1.39e-01
NCAM signaling for neurite out-growth	49	4.61e-02	-0.165000	1.61e-01
Signaling by the B Cell Receptor (BCR)	104	3.74e-03	0.165000	2.87e-02
Chondroitin sulfate biosynthesis	15	2.69e-01	0.165000	4.89e-01
Autodegradation of Cdh1 by Cdh1:APC/C	58	3.02e-02	0.165000	1.21e-01
Downstream TCR signaling	78	1.20e-02	0.165000	6.34e-02
VxPx cargo-targeting to cilium	18	2.27e-01	-0.164000	4.45e-01
Metabolism of steroids	110	2.96e-03	-0.164000	2.41e-02
Signaling by FGFR in disease	52	4.07e-02	-0.164000	1.46e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	68	1.94e-02	0.164000	9.24e-02
Resolution of D-Loop Structures	30	1.20e-01	0.164000	2.96e-01
Phase 2 - plateau phase	18	2.29e-01	-0.164000	4.47e-01
Vpr-mediated nuclear import of PICs	29	1.29e-01	-0.163000	3.07e-01
Late endosomal microautophagy	26	1.52e-01	-0.162000	3.43e-01
Retrograde neurotrophin signalling	13	3.12e-01	-0.162000	5.18e-01
Signaling by FGFR4 in disease	10	3.77e-01	-0.161000	5.90e-01
tRNA Aminoacylation	24	1.73e-01	-0.161000	3.75e-01
Signaling by FGFR1 in disease	31	1.22e-01	-0.161000	2.97e-01
Phase II - Conjugation of compounds	70	2.03e-02	0.161000	9.55e-02
TP53 Regulates Transcription of Cell Cycle Genes	46	6.01e-02	0.160000	1.87e-01
Metabolism of amino acids and derivatives	254	1.21e-05	0.160000	3.16e-04
FOXO-mediated transcription of cell cycle genes	16	2.68e-01	-0.160000	4.87e-01
AKT phosphorylates targets in the cytosol	14	3.01e-01	-0.160000	5.10e-01
Export of Viral Ribonucleoproteins from Nucleus	28	1.44e-01	-0.160000	3.31e-01
Signaling by NTRK1 (TRKA)	106	4.59e-03	-0.160000	3.22e-02
MAPK targets/ Nuclear events mediated by MAP kinases	31	1.25e-01	-0.159000	3.02e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	2.87e-01	0.159000	4.99e-01
Depolymerisation of the Nuclear Lamina	15	2.87e-01	0.159000	5.00e-01
COPI-mediated anterograde transport	77	1.66e-02	-0.158000	8.25e-02
Metabolism of folate and pterines	15	2.90e-01	-0.158000	5.01e-01
SHC-mediated cascade:FGFR3	12	3.44e-01	-0.158000	5.53e-01
HDR through Single Strand Annealing (SSA)	36	1.02e-01	0.158000	2.63e-01
Interleukin-15 signaling	14	3.08e-01	-0.157000	5.15e-01
MyD88 dependent cascade initiated on endosome	86	1.17e-02	-0.157000	6.20e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade	86	1.17e-02	-0.157000	6.20e-02
Inactivation, recovery and regulation of the phototransduction cascade	19	2.35e-01	-0.157000	4.51e-01
The phototransduction cascade	19	2.35e-01	-0.157000	4.51e-01
Transport of the SLBP independent Mature mRNA	30	1.36e-01	-0.157000	3.17e-01
Activation of NMDA receptors and postsynaptic events	64	3.01e-02	-0.157000	1.21e-01
mRNA decay by 3' to 5' exoribonuclease	15	2.93e-01	0.157000	5.03e-01
TBC/RABGAPs	40	8.65e-02	-0.157000	2.40e-01
ERBB2 Regulates Cell Motility	13	3.31e-01	-0.156000	5.37e-01
APC/C:Cdc20 mediated degradation of Securin	62	3.46e-02	0.155000	1.31e-01
Dual Incision in GG-NER	39	9.47e-02	0.155000	2.54e-01
Hedgehog ligand biogenesis	53	5.16e-02	0.155000	1.71e-01
Synthesis of substrates in N-glycan biosythesis	55	4.75e-02	-0.155000	1.65e-01
Gene Silencing by RNA	61	3.71e-02	-0.154000	1.38e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	26	1.75e-01	-0.154000	3.79e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	26	1.75e-01	-0.154000	3.79e-01
NF-kB is activated and signals survival	11	3.78e-01	-0.154000	5.90e-01
Basigin interactions	20	2.36e-01	0.153000	4.51e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	70	2.70e-02	-0.153000	1.16e-01
NOTCH1 Intracellular Domain Regulates Transcription	43	8.33e-02	-0.153000	2.36e-01
Nicotinate metabolism	24	1.97e-01	0.152000	4.06e-01
RAF activation	34	1.25e-01	-0.152000	3.03e-01
FGFR1 mutant receptor activation	24	1.98e-01	-0.152000	4.07e-01
Toll Like Receptor 9 (TLR9) Cascade	89	1.37e-02	-0.151000	7.00e-02
tRNA processing in the mitochondrion	16	2.95e-01	0.151000	5.04e-01
Activation of NF-kappaB in B cells	61	4.21e-02	0.151000	1.49e-01
DNA Double-Strand Break Repair	123	4.01e-03	0.150000	2.94e-02
Ub-specific processing proteases	165	9.27e-04	0.150000	1.11e-02
Reduction of cytosolic Ca++ levels	10	4.12e-01	-0.150000	6.26e-01
Negative regulation of MAPK pathway	40	1.02e-01	-0.150000	2.63e-01
Stimuli-sensing channels	56	5.29e-02	-0.150000	1.73e-01
Formation of the cornified envelope	18	2.73e-01	-0.149000	4.90e-01
CD28 co-stimulation	32	1.44e-01	0.149000	3.31e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	23	2.16e-01	-0.149000	4.29e-01
Ion channel transport	109	7.31e-03	-0.149000	4.45e-02
Growth hormone receptor signaling	19	2.61e-01	-0.149000	4.79e-01
Downstream signaling events of B Cell Receptor (BCR)	73	2.81e-02	0.149000	1.18e-01
MAP2K and MAPK activation	34	1.34e-01	0.149000	3.15e-01
Signaling by FGFR1	38	1.13e-01	-0.149000	2.84e-01
Budding and maturation of HIV virion	24	2.08e-01	-0.149000	4.21e-01
SARS-CoV-1 Infection	43	9.29e-02	-0.148000	2.50e-01
FCERI mediated Ca+2 mobilization	27	1.84e-01	0.148000	3.92e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	3.57e-01	0.148000	5.65e-01
Interactions of Vpr with host cellular proteins	31	1.56e-01	-0.147000	3.52e-01
SUMOylation of DNA methylation proteins	16	3.10e-01	-0.147000	5.16e-01
Cargo concentration in the ER	23	2.24e-01	-0.146000	4.41e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	29	1.73e-01	0.146000	3.76e-01
Ion transport by P-type ATPases	37	1.27e-01	-0.145000	3.04e-01
Cell Cycle	571	4.47e-09	0.145000	2.39e-07
Interleukin receptor SHC signaling	21	2.51e-01	0.145000	4.66e-01
Degradation of cysteine and homocysteine	12	3.86e-01	-0.145000	5.95e-01
Synthesis of pyrophosphates in the cytosol	10	4.29e-01	-0.144000	6.41e-01
Protein methylation	11	4.08e-01	0.144000	6.22e-01
MyD88-independent TLR4 cascade	91	1.76e-02	-0.144000	8.52e-02
TRIF(TICAM1)-mediated TLR4 signaling	91	1.76e-02	-0.144000	8.52e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	61	5.21e-02	0.144000	1.71e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	3.52e-01	-0.144000	5.61e-01
Cargo recognition for clathrin-mediated endocytosis	85	2.22e-02	-0.144000	1.02e-01
Regulation of insulin secretion	64	4.72e-02	-0.144000	1.64e-01
IRS-related events triggered by IGF1R	39	1.21e-01	-0.144000	2.97e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	2.68e-01	-0.143000	4.87e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	25	2.18e-01	-0.142000	4.31e-01
Transport of Mature mRNA Derived from an Intronless Transcript	37	1.34e-01	-0.142000	3.15e-01
Killing mechanisms	10	4.37e-01	-0.142000	6.49e-01
WNT5:FZD7-mediated leishmania damping	10	4.37e-01	-0.142000	6.49e-01
Downstream signaling of activated FGFR1	22	2.50e-01	-0.142000	4.64e-01
Circadian Clock	63	5.20e-02	-0.142000	1.71e-01
Synthesis of PC	24	2.30e-01	-0.142000	4.47e-01
Cell Cycle, Mitotic	458	2.78e-07	0.141000	1.03e-05
SUMOylation of chromatin organization proteins	49	8.87e-02	-0.141000	2.42e-01
Beta-oxidation of very long chain fatty acids	10	4.42e-01	0.140000	6.54e-01
Transcriptional Regulation by MECP2	46	1.00e-01	-0.140000	2.62e-01
Pre-NOTCH Processing in Golgi	16	3.32e-01	-0.140000	5.37e-01
SUMOylation of RNA binding proteins	41	1.22e-01	-0.140000	2.97e-01
Signaling by ERBB2 TMD/JMD mutants	19	2.92e-01	-0.140000	5.03e-01
Toll Like Receptor 3 (TLR3) Cascade	87	2.46e-02	-0.140000	1.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	89	2.31e-02	-0.140000	1.04e-01
Toll Like Receptor 2 (TLR2) Cascade	89	2.31e-02	-0.140000	1.04e-01
Toll Like Receptor TLR1:TLR2 Cascade	89	2.31e-02	-0.140000	1.04e-01
Toll Like Receptor TLR6:TLR2 Cascade	89	2.31e-02	-0.140000	1.04e-01
Host Interactions of HIV factors	112	1.09e-02	0.139000	5.94e-02
Caspase activation via Death Receptors in the presence of ligand	15	3.50e-01	0.139000	5.60e-01
Synthesis of bile acids and bile salts	23	2.47e-01	-0.139000	4.61e-01
Interleukin-10 signaling	27	2.11e-01	0.139000	4.23e-01
TNF signaling	37	1.43e-01	0.139000	3.31e-01
MET receptor recycling	10	4.48e-01	-0.139000	6.59e-01
mRNA Splicing - Major Pathway	168	2.02e-03	0.138000	1.90e-02
Neutrophil degranulation	360	7.95e-06	0.138000	2.21e-04
Fatty acid metabolism	131	6.61e-03	0.138000	4.22e-02
Biotin transport and metabolism	11	4.30e-01	-0.137000	6.42e-01
Mitophagy	25	2.35e-01	-0.137000	4.51e-01
NRAGE signals death through JNK	54	8.10e-02	-0.137000	2.32e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	22	2.65e-01	0.137000	4.85e-01
Innate Immune System	758	2.11e-10	0.137000	1.48e-08
Metabolism of RNA	600	1.36e-08	0.137000	6.16e-07
Transcriptional regulation by small RNAs	42	1.27e-01	-0.136000	3.04e-01
Negative regulators of DDX58/IFIH1 signaling	30	1.98e-01	0.136000	4.07e-01
Oxidative Stress Induced Senescence	60	6.95e-02	-0.136000	2.08e-01
Mitochondrial biogenesis	70	5.11e-02	-0.135000	1.70e-01
Insulin receptor signalling cascade	41	1.35e-01	-0.135000	3.16e-01
Signaling by high-kinase activity BRAF mutants	30	2.01e-01	0.135000	4.10e-01
Purine ribonucleoside monophosphate biosynthesis	12	4.19e-01	0.135000	6.32e-01
TNFs bind their physiological receptors	11	4.41e-01	0.134000	6.53e-01
Plasma lipoprotein clearance	25	2.47e-01	0.134000	4.61e-01
Downregulation of ERBB2 signaling	24	2.58e-01	-0.134000	4.74e-01
G beta:gamma signalling through CDC42	16	3.56e-01	0.133000	5.65e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	80	3.95e-02	0.133000	1.44e-01
Cellular response to hypoxia	64	6.56e-02	0.133000	1.99e-01
Signaling by ERBB2 KD Mutants	22	2.80e-01	-0.133000	4.94e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	3.30e-01	0.133000	5.36e-01
Meiotic recombination	22	2.83e-01	0.132000	4.94e-01
Deactivation of the beta-catenin transactivating complex	34	1.82e-01	-0.132000	3.90e-01
HCMV Late Events	48	1.17e-01	-0.131000	2.90e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	22	2.90e-01	-0.130000	5.01e-01
Transport of the SLBP Dependant Mature mRNA	31	2.09e-01	-0.130000	4.21e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	1.08e-01	-0.130000	2.74e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	27	2.42e-01	-0.130000	4.57e-01
Integrin cell surface interactions	53	1.02e-01	0.130000	2.63e-01
NEP/NS2 Interacts with the Cellular Export Machinery	27	2.43e-01	-0.130000	4.57e-01
DNA Repair	267	2.97e-04	0.129000	4.73e-03
SUMOylation of SUMOylation proteins	29	2.30e-01	-0.129000	4.47e-01
Peroxisomal lipid metabolism	25	2.65e-01	0.129000	4.85e-01
Transcriptional activation of mitochondrial biogenesis	50	1.15e-01	-0.129000	2.87e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	4.22e-01	-0.129000	6.34e-01
Defective EXT2 causes exostoses 2	13	4.22e-01	-0.129000	6.34e-01
Neuronal System	261	3.76e-04	-0.128000	5.83e-03
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	4.62e-01	0.128000	6.68e-01
rRNA modification in the nucleus and cytosol	53	1.07e-01	0.128000	2.73e-01
Potential therapeutics for SARS	35	1.91e-01	0.128000	4.01e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	33	2.05e-01	-0.128000	4.15e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	12	4.46e-01	0.127000	6.57e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	12	4.46e-01	0.127000	6.57e-01
Citric acid cycle (TCA cycle)	22	3.04e-01	-0.127000	5.13e-01
Keratan sulfate biosynthesis	21	3.17e-01	-0.126000	5.20e-01
mRNA Splicing	176	3.96e-03	0.126000	2.94e-02
Tie2 Signaling	16	3.86e-01	-0.125000	5.95e-01
Signaling by NTRK2 (TRKB)	22	3.10e-01	-0.125000	5.16e-01
Formation of tubulin folding intermediates by CCT/TriC	19	3.45e-01	-0.125000	5.54e-01
Regulation of PTEN stability and activity	62	8.93e-02	0.125000	2.43e-01
Gap junction trafficking and regulation	16	3.88e-01	-0.125000	5.96e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	2.92e-01	0.124000	5.03e-01
Separation of Sister Chromatids	154	8.02e-03	0.124000	4.74e-02
MET activates RAP1 and RAC1	11	4.76e-01	-0.124000	6.81e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	3.38e-01	-0.124000	5.45e-01
Cell-cell junction organization	26	2.76e-01	-0.124000	4.93e-01
Apoptotic factor-mediated response	13	4.41e-01	0.123000	6.53e-01
MASTL Facilitates Mitotic Progression	10	5.00e-01	0.123000	7.01e-01
Nuclear import of Rev protein	28	2.61e-01	-0.123000	4.79e-01
Dual incision in TC-NER	62	9.52e-02	0.123000	2.55e-01
Tight junction interactions	10	5.02e-01	-0.123000	7.04e-01
Peptide ligand-binding receptors	73	7.11e-02	0.122000	2.09e-01
Assembly and cell surface presentation of NMDA receptors	17	3.83e-01	-0.122000	5.93e-01
Opioid Signalling	78	6.36e-02	-0.122000	1.95e-01
Platelet sensitization by LDL	15	4.15e-01	-0.122000	6.28e-01
Resolution of Sister Chromatid Cohesion	95	4.12e-02	0.121000	1.48e-01
Signaling by ERBB2 ECD mutants	15	4.16e-01	-0.121000	6.29e-01
Keratan sulfate/keratin metabolism	26	2.85e-01	-0.121000	4.97e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	38	1.98e-01	-0.121000	4.07e-01
Signalling to ERKs	31	2.45e-01	-0.121000	4.60e-01
Glucagon signaling in metabolic regulation	27	2.78e-01	-0.121000	4.93e-01
Intra-Golgi traffic	40	1.89e-01	-0.120000	4.00e-01
Signaling by NOTCH2	27	2.81e-01	0.120000	4.94e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	24	3.10e-01	-0.120000	5.16e-01
Oncogenic MAPK signaling	72	7.95e-02	-0.120000	2.29e-01
Glycogen breakdown (glycogenolysis)	14	4.39e-01	-0.119000	6.52e-01
SHC1 events in EGFR signaling	11	4.93e-01	-0.119000	6.99e-01
Deubiquitination	238	1.58e-03	0.119000	1.64e-02
DNA Damage/Telomere Stress Induced Senescence	26	2.93e-01	0.119000	5.03e-01
Trafficking and processing of endosomal TLR	11	4.94e-01	0.119000	6.99e-01
G-protein beta:gamma signalling	28	2.76e-01	0.119000	4.93e-01
IGF1R signaling cascade	40	1.94e-01	-0.119000	4.02e-01
Kinesins	37	2.12e-01	0.119000	4.23e-01
Signaling by ERBB2 in Cancer	23	3.25e-01	-0.119000	5.31e-01
ADP signalling through P2Y purinoceptor 12	18	3.86e-01	0.118000	5.95e-01
Diseases of programmed cell death	20	3.65e-01	0.117000	5.75e-01
Interaction between L1 and Ankyrins	23	3.32e-01	-0.117000	5.37e-01
Transcriptional regulation by RUNX3	88	5.83e-02	0.117000	1.84e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	4.35e-01	0.116000	6.48e-01
MyD88 deficiency (TLR2/4)	10	5.26e-01	0.116000	7.25e-01
Transmission across Chemical Synapses	172	8.93e-03	-0.116000	5.14e-02
Postmitotic nuclear pore complex (NPC) reformation	25	3.16e-01	-0.116000	5.20e-01
Signaling by TGF-beta Receptor Complex	67	1.02e-01	-0.116000	2.63e-01
DARPP-32 events	22	3.48e-01	-0.116000	5.57e-01
HS-GAG biosynthesis	23	3.37e-01	-0.116000	5.44e-01
Viral Messenger RNA Synthesis	38	2.18e-01	-0.116000	4.31e-01
FCERI mediated NF-kB activation	72	9.08e-02	0.115000	2.45e-01
Notch-HLH transcription pathway	25	3.19e-01	-0.115000	5.23e-01
Netrin-1 signaling	41	2.02e-01	-0.115000	4.12e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	4.90e-01	0.115000	6.97e-01
Signaling by FGFR	67	1.05e-01	-0.115000	2.70e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	41	2.05e-01	-0.114000	4.15e-01
Signaling by Insulin receptor	59	1.29e-01	-0.114000	3.07e-01
cGMP effects	13	4.76e-01	0.114000	6.81e-01
Sphingolipid de novo biosynthesis	33	2.58e-01	-0.114000	4.74e-01
Regulation of RUNX2 expression and activity	64	1.16e-01	0.114000	2.87e-01
Collagen degradation	26	3.15e-01	-0.114000	5.20e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	3.68e-01	-0.114000	5.77e-01
Nucleobase catabolism	31	2.74e-01	0.113000	4.92e-01
RNA Polymerase II Pre-transcription Events	75	8.99e-02	-0.113000	2.43e-01
Regulation of TLR by endogenous ligand	10	5.35e-01	0.113000	7.32e-01
EPH-Ephrin signaling	83	7.58e-02	0.113000	2.21e-01
RHO GTPase Effectors	220	4.03e-03	0.113000	2.94e-02
Role of LAT2/NTAL/LAB on calcium mobilization	14	4.66e-01	0.113000	6.72e-01
Amino acid transport across the plasma membrane	22	3.62e-01	-0.112000	5.71e-01
GAB1 signalosome	14	4.69e-01	-0.112000	6.75e-01
Acyl chain remodelling of PC	18	4.13e-01	0.111000	6.27e-01
Peptide hormone metabolism	54	1.58e-01	-0.111000	3.54e-01
Translation	230	3.91e-03	0.111000	2.94e-02
IRAK4 deficiency (TLR2/4)	11	5.25e-01	0.111000	7.25e-01
Transcriptional Regulation by VENTX	35	2.58e-01	-0.111000	4.74e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	17	4.33e-01	-0.110000	6.45e-01
RNA Polymerase III Transcription Termination	23	3.63e-01	0.110000	5.72e-01
Other semaphorin interactions	19	4.10e-01	0.109000	6.24e-01
Biological oxidations	135	2.88e-02	0.109000	1.19e-01
Infection with Mycobacterium tuberculosis	23	3.66e-01	0.109000	5.75e-01
Platelet calcium homeostasis	22	3.78e-01	-0.109000	5.90e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	27	3.29e-01	0.109000	5.36e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	4.99e-01	-0.108000	7.01e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	4.27e-01	0.108000	6.39e-01
Synthesis, secretion, and deacylation of Ghrelin	11	5.36e-01	0.108000	7.32e-01
mRNA Capping	28	3.25e-01	-0.107000	5.31e-01
Leishmania infection	169	1.69e-02	0.107000	8.34e-02
Degradation of beta-catenin by the destruction complex	75	1.11e-01	0.107000	2.80e-01
SLC transporter disorders	66	1.36e-01	-0.106000	3.17e-01
Aggrephagy	17	4.48e-01	-0.106000	6.59e-01
Formation of the Early Elongation Complex	32	3.00e-01	-0.106000	5.10e-01
Formation of the HIV-1 Early Elongation Complex	32	3.00e-01	-0.106000	5.10e-01
Neurotransmitter receptors and postsynaptic signal transmission	129	3.90e-02	-0.105000	1.42e-01
Processing of Capped Intron-Containing Pre-mRNA	221	7.37e-03	0.105000	4.45e-02
Formation of RNA Pol II elongation complex	53	1.87e-01	-0.105000	3.98e-01
RNA Polymerase II Transcription Elongation	53	1.87e-01	-0.105000	3.98e-01
SHC1 events in ERBB2 signaling	20	4.19e-01	-0.104000	6.32e-01
Protein-protein interactions at synapses	62	1.58e-01	-0.104000	3.54e-01
Gastrin-CREB signalling pathway via PKC and MAPK	16	4.73e-01	-0.104000	6.81e-01
Ca2+ pathway	53	1.93e-01	-0.103000	4.01e-01
Synthesis of very long-chain fatty acyl-CoAs	14	5.04e-01	-0.103000	7.05e-01
Response to elevated platelet cytosolic Ca2+	106	6.90e-02	0.102000	2.07e-01
Metalloprotease DUBs	18	4.53e-01	0.102000	6.63e-01
Membrane Trafficking	537	6.26e-05	-0.102000	1.33e-03
Chaperone Mediated Autophagy	15	4.96e-01	-0.102000	7.00e-01
Potassium Channels	63	1.67e-01	-0.101000	3.67e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	65	1.64e-01	0.099900	3.64e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	19	4.52e-01	0.099800	6.61e-01
Neurodegenerative Diseases	19	4.52e-01	0.099800	6.61e-01
Glucagon-type ligand receptors	17	4.76e-01	0.099800	6.81e-01
MAPK6/MAPK4 signaling	79	1.27e-01	0.099500	3.04e-01
Hedgehog 'on' state	75	1.39e-01	0.098900	3.22e-01
Platelet degranulation	101	8.65e-02	0.098900	2.40e-01
Late Phase of HIV Life Cycle	121	6.09e-02	-0.098800	1.88e-01
Regulation of IFNG signaling	13	5.39e-01	0.098500	7.34e-01
Nonhomologous End-Joining (NHEJ)	33	3.28e-01	0.098400	5.35e-01
TP53 Regulates Transcription of Cell Death Genes	36	3.08e-01	0.098300	5.15e-01
Signaling by PDGFR in disease	20	4.49e-01	-0.097900	6.59e-01
C-type lectin receptors (CLRs)	110	7.76e-02	0.097600	2.26e-01
G2/M Transition	173	2.74e-02	0.097500	1.18e-01
Chondroitin sulfate/dermatan sulfate metabolism	41	2.82e-01	0.097200	4.94e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	3.84e-01	0.096800	5.94e-01
Gap junction trafficking	14	5.31e-01	-0.096800	7.27e-01
Diseases of metabolism	179	2.60e-02	-0.096700	1.13e-01
Protein ubiquitination	56	2.11e-01	-0.096700	4.23e-01
Mitochondrial calcium ion transport	20	4.55e-01	-0.096500	6.63e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	34	3.30e-01	-0.096500	5.36e-01
Elastic fibre formation	38	3.04e-01	-0.096400	5.13e-01
Semaphorin interactions	63	1.88e-01	0.096000	3.98e-01
Mitotic G2-G2/M phases	175	2.89e-02	0.096000	1.19e-01
Adaptive Immune System	585	8.65e-05	0.095900	1.77e-03
p75NTR signals via NF-kB	14	5.37e-01	-0.095300	7.32e-01
Fc epsilon receptor (FCERI) signaling	121	7.21e-02	0.094900	2.12e-01
HCMV Infection	74	1.60e-01	-0.094700	3.57e-01
Vesicle-mediated transport	569	1.30e-04	-0.094700	2.49e-03
Nuclear Envelope (NE) Reassembly	65	1.88e-01	-0.094600	3.98e-01
Class A/1 (Rhodopsin-like receptors)	126	6.78e-02	0.094400	2.04e-01
Metabolism of nucleotides	87	1.29e-01	0.094300	3.07e-01
RHO GTPases activate PKNs	32	3.56e-01	0.094300	5.65e-01
Immune System	1549	1.94e-09	0.093700	1.13e-07
HIV Transcription Initiation	45	2.78e-01	-0.093500	4.93e-01
RNA Polymerase II HIV Promoter Escape	45	2.78e-01	-0.093500	4.93e-01
RNA Polymerase II Promoter Escape	45	2.78e-01	-0.093500	4.93e-01
RNA Polymerase II Transcription Initiation	45	2.78e-01	-0.093500	4.93e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	2.78e-01	-0.093500	4.93e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	2.78e-01	-0.093500	4.93e-01
Global Genome Nucleotide Excision Repair (GG-NER)	80	1.50e-01	0.093200	3.41e-01
SUMOylation of ubiquitinylation proteins	33	3.56e-01	-0.092900	5.65e-01
Inositol phosphate metabolism	42	2.98e-01	-0.092900	5.07e-01
Signaling by PDGF	48	2.67e-01	-0.092700	4.87e-01
Golgi Associated Vesicle Biogenesis	52	2.50e-01	-0.092400	4.64e-01
Platelet activation, signaling and aggregation	211	2.13e-02	0.092300	9.79e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	1.69e-01	0.092000	3.70e-01
Nuclear Pore Complex (NPC) Disassembly	31	3.75e-01	-0.092000	5.88e-01
Apoptotic cleavage of cellular proteins	33	3.61e-01	-0.092000	5.71e-01
Hyaluronan metabolism	14	5.52e-01	0.091800	7.42e-01
Deadenylation of mRNA	24	4.38e-01	0.091500	6.50e-01
TCF dependent signaling in response to WNT	146	5.85e-02	-0.090900	1.84e-01
Signaling by ERBB2	43	3.03e-01	-0.090800	5.12e-01
Pre-NOTCH Expression and Processing	47	2.82e-01	-0.090800	4.94e-01
Suppression of phagosomal maturation	11	6.03e-01	-0.090600	7.88e-01
Cargo trafficking to the periciliary membrane	45	2.93e-01	-0.090600	5.03e-01
RNA polymerase II transcribes snRNA genes	70	1.91e-01	-0.090500	4.01e-01
Unblocking of NMDA receptors, glutamate binding and activation	15	5.44e-01	-0.090500	7.37e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	30	3.95e-01	-0.089800	6.03e-01
Incretin synthesis, secretion, and inactivation	12	5.94e-01	0.088800	7.82e-01
Glycerophospholipid biosynthesis	96	1.34e-01	-0.088600	3.15e-01
RUNX2 regulates bone development	28	4.18e-01	-0.088400	6.32e-01
Post-chaperonin tubulin folding pathway	17	5.28e-01	-0.088400	7.26e-01
FOXO-mediated transcription of cell death genes	14	5.68e-01	-0.088100	7.58e-01
RMTs methylate histone arginines	29	4.14e-01	-0.087600	6.28e-01
FGFR2 alternative splicing	24	4.58e-01	-0.087600	6.64e-01
CRMPs in Sema3A signaling	15	5.58e-01	0.087400	7.46e-01
p130Cas linkage to MAPK signaling for integrins	12	6.00e-01	0.087400	7.88e-01
Post-translational modification: synthesis of GPI-anchored proteins	59	2.47e-01	-0.087200	4.61e-01
SHC-mediated cascade:FGFR1	12	6.01e-01	-0.087100	7.88e-01
Metabolism of carbohydrates	231	2.33e-02	-0.087000	1.04e-01
SHC1 events in ERBB4 signaling	12	6.03e-01	-0.086600	7.88e-01
Infectious disease	572	4.48e-04	0.086600	6.29e-03
Nucleotide Excision Repair	105	1.28e-01	0.086100	3.06e-01
Metabolic disorders of biological oxidation enzymes	19	5.17e-01	-0.085900	7.17e-01
BBSome-mediated cargo-targeting to cilium	20	5.12e-01	-0.084800	7.13e-01
Intrinsic Pathway for Apoptosis	44	3.36e-01	0.083800	5.43e-01
Visual phototransduction	54	2.90e-01	-0.083300	5.01e-01
Presynaptic function of Kainate receptors	17	5.53e-01	0.083200	7.42e-01
Transport of Mature Transcript to Cytoplasm	74	2.17e-01	0.083100	4.30e-01
Antiviral mechanism by IFN-stimulated genes	70	2.30e-01	0.083000	4.47e-01
Nuclear Receptor transcription pathway	43	3.48e-01	-0.082800	5.57e-01
Peroxisomal protein import	54	2.95e-01	0.082500	5.04e-01
Sema4D in semaphorin signaling	24	4.87e-01	0.082000	6.94e-01
HCMV Early Events	53	3.02e-01	-0.082000	5.12e-01
Diseases associated with the TLR signaling cascade	22	5.06e-01	-0.081900	7.07e-01
Diseases of Immune System	22	5.06e-01	-0.081900	7.07e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	5.00e-01	-0.081300	7.01e-01
G alpha (12/13) signalling events	71	2.37e-01	-0.081200	4.51e-01
Golgi-to-ER retrograde transport	105	1.51e-01	-0.081200	3.42e-01
Post-translational protein phosphorylation	72	2.34e-01	-0.081100	4.51e-01
Cytosolic sensors of pathogen-associated DNA	57	2.90e-01	0.081100	5.01e-01
SUMOylation of transcription cofactors	39	3.81e-01	-0.081100	5.92e-01
Activation of BH3-only proteins	27	4.66e-01	0.081100	6.72e-01
Rab regulation of trafficking	114	1.36e-01	-0.081000	3.17e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	39	3.83e-01	-0.080900	5.93e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	47	3.39e-01	0.080600	5.46e-01
Diseases of DNA repair	10	6.59e-01	0.080500	8.26e-01
Protein localization	144	9.65e-02	0.080400	2.56e-01
WNT5A-dependent internalization of FZD4	15	5.91e-01	-0.080200	7.80e-01
NS1 Mediated Effects on Host Pathways	33	4.27e-01	-0.079900	6.39e-01
Activation of G protein gated Potassium channels	20	5.43e-01	0.078600	7.36e-01
G protein gated Potassium channels	20	5.43e-01	0.078600	7.36e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	5.43e-01	0.078600	7.36e-01
TP53 Regulates Transcription of DNA Repair Genes	57	3.05e-01	0.078600	5.13e-01
Mitotic Metaphase and Anaphase	207	5.25e-02	0.078400	1.72e-01
Unfolded Protein Response (UPR)	84	2.15e-01	-0.078300	4.28e-01
FOXO-mediated transcription	55	3.16e-01	-0.078300	5.20e-01
Hemostasis	453	4.59e-03	0.078300	3.22e-02
Thromboxane signalling through TP receptor	20	5.46e-01	0.078100	7.38e-01
RIP-mediated NFkB activation via ZBP1	17	5.77e-01	-0.078100	7.66e-01
TP53 Regulates Metabolic Genes	83	2.20e-01	-0.078100	4.33e-01
Asymmetric localization of PCP proteins	58	3.05e-01	0.078000	5.13e-01
Anti-inflammatory response favouring Leishmania parasite infection	95	1.90e-01	0.077900	4.00e-01
Leishmania parasite growth and survival	95	1.90e-01	0.077900	4.00e-01
ERK/MAPK targets	22	5.28e-01	-0.077800	7.26e-01
Metabolism of water-soluble vitamins and cofactors	102	1.76e-01	-0.077600	3.80e-01
Signaling by BRAF and RAF fusions	56	3.16e-01	-0.077500	5.20e-01
Mitotic Prometaphase	175	7.82e-02	0.077400	2.26e-01
Chromatin modifying enzymes	186	7.04e-02	-0.077200	2.09e-01
Chromatin organization	186	7.04e-02	-0.077200	2.09e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	6.31e-01	-0.077000	8.05e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	5.52e-01	-0.076800	7.42e-01
Signaling by ERBB4	45	3.74e-01	-0.076700	5.85e-01
GABA receptor activation	39	4.08e-01	-0.076600	6.22e-01
Estrogen-dependent gene expression	83	2.29e-01	-0.076500	4.47e-01
Regulation of TP53 Activity through Methylation	14	6.21e-01	-0.076400	7.97e-01
Signaling by FGFR3 fusions in cancer	10	6.76e-01	-0.076400	8.35e-01
Neurotransmitter release cycle	32	4.58e-01	-0.075800	6.65e-01
Cellular hexose transport	11	6.64e-01	-0.075700	8.29e-01
Regulation of PTEN gene transcription	59	3.16e-01	-0.075600	5.20e-01
HIV Life Cycle	133	1.34e-01	-0.075400	3.15e-01
Muscle contraction	159	1.02e-01	-0.075400	2.63e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	83	2.38e-01	0.075100	4.51e-01
Amplification of signal from the kinetochores	83	2.38e-01	0.075100	4.51e-01
PIWI-interacting RNA (piRNA) biogenesis	18	5.83e-01	-0.074800	7.72e-01
IL-6-type cytokine receptor ligand interactions	12	6.54e-01	0.074800	8.21e-01
ABC-family proteins mediated transport	85	2.35e-01	0.074700	4.51e-01
VEGFR2 mediated vascular permeability	27	5.03e-01	-0.074500	7.04e-01
Caspase activation via extrinsic apoptotic signalling pathway	24	5.28e-01	0.074500	7.26e-01
Elevation of cytosolic Ca2+ levels	12	6.56e-01	-0.074200	8.23e-01
Mitotic Anaphase	206	6.78e-02	0.074100	2.04e-01
G beta:gamma signalling through PLC beta	16	6.08e-01	0.074000	7.90e-01
Transcription of the HIV genome	64	3.08e-01	-0.073800	5.15e-01
Toll Like Receptor 4 (TLR4) Cascade	117	1.70e-01	-0.073600	3.71e-01
Signaling by Rho GTPases	339	2.05e-02	0.073600	9.61e-02
PINK1-PRKN Mediated Mitophagy	18	5.90e-01	-0.073500	7.80e-01
Iron uptake and transport	48	3.80e-01	-0.073400	5.91e-01
Deadenylation-dependent mRNA decay	54	3.52e-01	0.073300	5.61e-01
RUNX3 regulates NOTCH signaling	14	6.35e-01	-0.073200	8.07e-01
Signaling by NTRK3 (TRKC)	17	6.02e-01	-0.073100	7.88e-01
The canonical retinoid cycle in rods (twilight vision)	10	6.89e-01	-0.073000	8.40e-01
Amino acids regulate mTORC1	48	3.82e-01	-0.073000	5.93e-01
FCGR3A-mediated IL10 synthesis	40	4.25e-01	0.072900	6.39e-01
Translesion Synthesis by POLH	16	6.14e-01	0.072800	7.94e-01
RHO GTPases Activate Formins	109	1.92e-01	0.072400	4.01e-01
Programmed Cell Death	152	1.24e-01	0.072400	3.01e-01
Acyl chain remodelling of PE	16	6.16e-01	0.072400	7.95e-01
Downregulation of ERBB2:ERBB3 signaling	11	6.78e-01	-0.072300	8.35e-01
Metabolism of non-coding RNA	48	3.87e-01	-0.072200	5.95e-01
snRNP Assembly	48	3.87e-01	-0.072200	5.95e-01
Surfactant metabolism	14	6.40e-01	-0.072100	8.11e-01
Diseases associated with glycosylation precursor biosynthesis	18	5.97e-01	-0.071900	7.85e-01
Constitutive Signaling by Overexpressed ERBB2	10	6.94e-01	-0.071900	8.42e-01
Triglyceride metabolism	23	5.51e-01	0.071900	7.42e-01
Negative epigenetic regulation of rRNA expression	48	3.91e-01	0.071600	5.99e-01
Organelle biogenesis and maintenance	241	5.65e-02	-0.071600	1.80e-01
Bile acid and bile salt metabolism	26	5.30e-01	-0.071300	7.26e-01
Cell death signalling via NRAGE, NRIF and NADE	68	3.10e-01	-0.071200	5.16e-01
M Phase	323	2.91e-02	0.071000	1.19e-01
Signaling by NOTCH1	66	3.20e-01	-0.070900	5.23e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	78	2.83e-01	-0.070400	4.94e-01
E3 ubiquitin ligases ubiquitinate target proteins	39	4.56e-01	-0.069000	6.64e-01
RHO GTPases Activate ROCKs	19	6.04e-01	0.068700	7.89e-01
Apoptosis	149	1.49e-01	0.068600	3.41e-01
Signaling by Interleukins	352	2.81e-02	0.068500	1.18e-01
SUMOylation of DNA replication proteins	40	4.54e-01	0.068400	6.63e-01
Regulation of TP53 Expression and Degradation	33	4.99e-01	-0.068100	7.01e-01
rRNA processing in the mitochondrion	17	6.29e-01	0.067600	8.05e-01
Diseases of signal transduction by growth factor receptors and second messengers	336	3.43e-02	-0.067500	1.31e-01
Metabolism of porphyrins	21	5.92e-01	-0.067500	7.81e-01
Cytokine Signaling in Immune system	662	3.45e-03	0.067300	2.73e-02
Cellular Senescence	118	2.09e-01	-0.067100	4.21e-01
TICAM1-dependent activation of IRF3/IRF7	10	7.13e-01	0.067100	8.58e-01
VEGFA-VEGFR2 Pathway	90	2.72e-01	0.067000	4.90e-01
RNA Polymerase I Promoter Escape	30	5.29e-01	-0.066500	7.26e-01
PCP/CE pathway	85	2.91e-01	0.066300	5.03e-01
Signaling by Receptor Tyrosine Kinases	420	2.08e-02	-0.066200	9.68e-02
Signaling by WNT	226	8.77e-02	-0.066200	2.40e-01
RNA Polymerase III Chain Elongation	18	6.27e-01	0.066100	8.03e-01
Clathrin-mediated endocytosis	122	2.09e-01	-0.065900	4.21e-01
Mitochondrial translation	91	2.79e-01	-0.065800	4.93e-01
Axon guidance	435	1.96e-02	0.065700	9.30e-02
ERKs are inactivated	13	6.85e-01	0.065000	8.38e-01
Signaling by MET	61	3.81e-01	-0.064900	5.92e-01
Transcriptional regulation by RUNX2	108	2.46e-01	0.064800	4.60e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	168	1.49e-01	-0.064800	3.39e-01
Apoptotic execution phase	41	4.74e-01	-0.064600	6.81e-01
Rev-mediated nuclear export of HIV RNA	30	5.41e-01	-0.064600	7.35e-01
Mitochondrial protein import	59	3.92e-01	0.064500	6.00e-01
Interleukin-2 signaling	11	7.12e-01	0.064300	8.57e-01
Interactions of Rev with host cellular proteins	31	5.36e-01	-0.064300	7.32e-01
Signaling by VEGF	98	2.73e-01	0.064200	4.90e-01
Fanconi Anemia Pathway	31	5.41e-01	0.063500	7.35e-01
Synthesis of PIPs at the late endosome membrane	11	7.18e-01	0.063000	8.59e-01
CLEC7A (Dectin-1) signaling	89	3.07e-01	0.062700	5.15e-01
Amyloid fiber formation	36	5.20e-01	0.062000	7.19e-01
Interleukin-6 family signaling	18	6.57e-01	0.060600	8.23e-01
Regulation of localization of FOXO transcription factors	12	7.17e-01	-0.060400	8.59e-01
Insulin receptor recycling	19	6.53e-01	-0.059500	8.21e-01
Metabolism of cofactors	19	6.54e-01	-0.059500	8.21e-01
Metabolism of vitamins and cofactors	151	2.10e-01	-0.059300	4.21e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	7.36e-01	-0.058800	8.70e-01
eNOS activation	11	7.37e-01	0.058600	8.70e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	6.36e-01	-0.058300	8.07e-01
Cell-extracellular matrix interactions	16	6.88e-01	0.058100	8.39e-01
Plasma lipoprotein remodeling	15	7.00e-01	0.057500	8.46e-01
Defective B4GALT7 causes EDS, progeroid type	16	6.92e-01	0.057300	8.41e-01
RNA Pol II CTD phosphorylation and interaction with CE	26	6.14e-01	-0.057100	7.94e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	6.14e-01	-0.057100	7.94e-01
Glutamate and glutamine metabolism	12	7.34e-01	0.056700	8.70e-01
Signaling by KIT in disease	20	6.62e-01	0.056500	8.27e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	6.62e-01	0.056500	8.27e-01
PKMTs methylate histone lysines	37	5.53e-01	-0.056400	7.42e-01
Keratinization	23	6.40e-01	-0.056300	8.11e-01
Activation of HOX genes during differentiation	54	4.77e-01	-0.056000	6.81e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	54	4.77e-01	-0.056000	6.81e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	5.51e-01	-0.055900	7.42e-01
HIV Transcription Elongation	38	5.51e-01	-0.055900	7.42e-01
Tat-mediated elongation of the HIV-1 transcript	38	5.51e-01	-0.055900	7.42e-01
Intracellular signaling by second messengers	276	1.12e-01	-0.055900	2.81e-01
Class B/2 (Secretin family receptors)	44	5.23e-01	-0.055700	7.23e-01
Toll-like Receptor Cascades	133	2.70e-01	-0.055500	4.89e-01
Response of Mtb to phagocytosis	20	6.68e-01	0.055500	8.31e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	52	4.94e-01	-0.054800	6.99e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	52	4.94e-01	-0.054800	6.99e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	52	4.94e-01	-0.054800	6.99e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	52	4.94e-01	-0.054800	6.99e-01
Signaling by NOTCH1 in Cancer	52	4.94e-01	-0.054800	6.99e-01
Platelet Aggregation (Plug Formation)	25	6.36e-01	0.054700	8.07e-01
CaMK IV-mediated phosphorylation of CREB	10	7.64e-01	-0.054700	8.89e-01
Regulation of TP53 Degradation	32	5.92e-01	-0.054700	7.81e-01
WNT ligand biogenesis and trafficking	13	7.34e-01	-0.054500	8.70e-01
N-Glycan antennae elongation	13	7.34e-01	-0.054400	8.70e-01
Regulation of signaling by CBL	18	6.93e-01	0.053800	8.41e-01
Molecules associated with elastic fibres	28	6.24e-01	-0.053600	8.00e-01
Nuclear signaling by ERBB4	27	6.31e-01	-0.053400	8.05e-01
A tetrasaccharide linker sequence is required for GAG synthesis	20	6.81e-01	0.053200	8.36e-01
VEGFR2 mediated cell proliferation	19	6.89e-01	0.053100	8.40e-01
Activated NOTCH1 Transmits Signal to the Nucleus	26	6.41e-01	0.052800	8.11e-01
Synthesis of IP3 and IP4 in the cytosol	21	6.76e-01	-0.052700	8.35e-01
Lysosome Vesicle Biogenesis	31	6.15e-01	0.052200	7.94e-01
LDL clearance	16	7.19e-01	0.052000	8.59e-01
Adrenaline,noradrenaline inhibits insulin secretion	22	6.76e-01	0.051600	8.35e-01
EML4 and NUDC in mitotic spindle formation	87	4.08e-01	0.051300	6.22e-01
The citric acid (TCA) cycle and respiratory electron transport	149	2.81e-01	0.051300	4.94e-01
Plasma lipoprotein assembly	10	7.79e-01	-0.051300	8.93e-01
Transcriptional regulation by RUNX1	155	2.72e-01	0.051300	4.90e-01
GPCR ligand binding	173	2.46e-01	0.051200	4.61e-01
TICAM1, RIP1-mediated IKK complex recruitment	16	7.23e-01	-0.051200	8.61e-01
Ovarian tumor domain proteases	34	6.07e-01	0.050900	7.90e-01
Interleukin-2 family signaling	34	6.08e-01	0.050900	7.90e-01
Effects of PIP2 hydrolysis	22	6.81e-01	-0.050600	8.36e-01
IKK complex recruitment mediated by RIP1	19	7.04e-01	-0.050300	8.51e-01
Nervous system development	453	6.97e-02	0.050100	2.08e-01
Oncogene Induced Senescence	29	6.41e-01	0.050000	8.11e-01
Cellular responses to external stimuli	429	8.21e-02	0.049300	2.35e-01
Dopamine Neurotransmitter Release Cycle	16	7.35e-01	0.048900	8.70e-01
Signaling by RAF1 mutants	35	6.19e-01	0.048500	7.97e-01
Retrograde transport at the Trans-Golgi-Network	45	5.75e-01	-0.048300	7.66e-01
Cell junction organization	50	5.56e-01	-0.048200	7.45e-01
Nucleobase biosynthesis	15	7.47e-01	0.048100	8.78e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	11	7.82e-01	-0.048100	8.95e-01
Phase I - Functionalization of compounds	61	5.17e-01	0.048000	7.17e-01
Cytochrome P450 - arranged by substrate type	31	6.45e-01	0.047900	8.14e-01
PI3K/AKT Signaling in Cancer	84	4.49e-01	-0.047800	6.59e-01
PRC2 methylates histones and DNA	14	7.57e-01	0.047700	8.87e-01
RAB geranylgeranylation	50	5.63e-01	0.047300	7.52e-01
Thrombin signalling through proteinase activated receptors (PARs)	26	6.78e-01	0.047100	8.35e-01
RAB GEFs exchange GTP for GDP on RABs	84	4.57e-01	-0.047000	6.64e-01
Norepinephrine Neurotransmitter Release Cycle	11	7.87e-01	-0.047000	8.98e-01
Transport of small molecules	498	7.89e-02	-0.046400	2.27e-01
ZBP1(DAI) mediated induction of type I IFNs	20	7.20e-01	-0.046300	8.60e-01
Cellular responses to stress	424	1.06e-01	0.046100	2.72e-01
CD28 dependent PI3K/Akt signaling	21	7.17e-01	0.045700	8.59e-01
MHC class II antigen presentation	90	4.59e-01	0.045200	6.65e-01
SUMO E3 ligases SUMOylate target proteins	144	3.53e-01	0.045000	5.62e-01
Downstream signal transduction	28	6.81e-01	-0.045000	8.36e-01
Diseases associated with O-glycosylation of proteins	45	6.03e-01	0.044900	7.88e-01
Mitochondrial translation termination	85	4.75e-01	-0.044900	6.81e-01
Neurexins and neuroligins	38	6.32e-01	-0.044900	8.06e-01
tRNA modification in the nucleus and cytosol	38	6.34e-01	0.044700	8.07e-01
Cilium Assembly	171	3.15e-01	-0.044700	5.20e-01
NOTCH4 Intracellular Domain Regulates Transcription	18	7.46e-01	-0.044100	8.78e-01
Activation of kainate receptors upon glutamate binding	25	7.08e-01	0.043300	8.55e-01
Interleukin-35 Signalling	10	8.13e-01	0.043200	9.15e-01
NoRC negatively regulates rRNA expression	45	6.19e-01	0.042900	7.97e-01
Synthesis of PIPs at the early endosome membrane	16	7.67e-01	0.042900	8.89e-01
Interleukin-1 signaling	90	4.84e-01	0.042800	6.90e-01
Factors involved in megakaryocyte development and platelet production	103	4.56e-01	0.042600	6.64e-01
Interleukin-6 signaling	10	8.17e-01	-0.042400	9.16e-01
SUMOylation	150	3.74e-01	0.042200	5.85e-01
Signaling by NOTCH	159	3.63e-01	0.041900	5.72e-01
Processing of Capped Intronless Pre-mRNA	26	7.12e-01	0.041900	8.57e-01
Plasma lipoprotein assembly, remodeling, and clearance	48	6.18e-01	0.041600	7.97e-01
Defective B3GAT3 causes JDSSDHD	16	7.74e-01	0.041600	8.91e-01
Acyl chain remodelling of PG	11	8.12e-01	0.041400	9.15e-01
SLBP independent Processing of Histone Pre-mRNAs	10	8.21e-01	-0.041400	9.16e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	8.21e-01	-0.041400	9.16e-01
Processing of Intronless Pre-mRNAs	17	7.69e-01	-0.041100	8.89e-01
MET activates PTK2 signaling	17	7.70e-01	-0.041000	8.89e-01
Post-translational protein modification	1125	2.33e-02	-0.040800	1.04e-01
Metabolism of steroid hormones	18	7.65e-01	0.040700	8.89e-01
Long-term potentiation	18	7.66e-01	-0.040600	8.89e-01
Signaling by Hedgehog	120	4.43e-01	-0.040600	6.54e-01
L1CAM interactions	87	5.15e-01	-0.040400	7.16e-01
mRNA decay by 5' to 3' exoribonuclease	15	7.88e-01	-0.040100	8.98e-01
Collagen chain trimerization	34	6.87e-01	-0.039900	8.39e-01
Mucopolysaccharidoses	11	8.20e-01	-0.039700	9.16e-01
MET promotes cell motility	28	7.16e-01	-0.039700	8.59e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	56	6.09e-01	0.039600	7.90e-01
Mitochondrial translation initiation	85	5.29e-01	-0.039600	7.26e-01
trans-Golgi Network Vesicle Budding	67	5.77e-01	-0.039400	7.66e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	6.82e-01	0.039400	8.36e-01
Diseases of mitotic cell cycle	36	6.82e-01	0.039400	8.36e-01
Syndecan interactions	20	7.61e-01	-0.039300	8.89e-01
RNA Polymerase III Abortive And Retractive Initiation	41	6.65e-01	0.039100	8.29e-01
RNA Polymerase III Transcription	41	6.65e-01	0.039100	8.29e-01
Pyrimidine catabolism	10	8.32e-01	0.038800	9.20e-01
Non-integrin membrane-ECM interactions	40	6.72e-01	-0.038800	8.35e-01
Ephrin signaling	19	7.71e-01	0.038600	8.89e-01
ESR-mediated signaling	144	4.26e-01	-0.038500	6.39e-01
Sphingolipid metabolism	67	5.88e-01	-0.038400	7.78e-01
Heparan sulfate/heparin (HS-GAG) metabolism	40	6.77e-01	-0.038100	8.35e-01
Beta-catenin independent WNT signaling	130	4.54e-01	0.038100	6.63e-01
Phospholipid metabolism	174	3.91e-01	-0.037800	5.99e-01
Mitotic Spindle Checkpoint	100	5.15e-01	0.037700	7.16e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	35	7.00e-01	-0.037700	8.46e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	6.81e-01	-0.037500	8.36e-01
Cristae formation	11	8.30e-01	0.037500	9.20e-01
Signaling by NOTCH3	43	6.78e-01	0.036600	8.35e-01
Signaling by SCF-KIT	42	6.83e-01	0.036400	8.36e-01
tRNA processing in the nucleus	52	6.51e-01	-0.036300	8.20e-01
Diseases of glycosylation	112	5.09e-01	-0.036200	7.10e-01
Degradation of the extracellular matrix	74	5.94e-01	-0.035900	7.81e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	7.77e-01	-0.035700	8.92e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	7.77e-01	-0.035700	8.92e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	8.11e-01	-0.035700	9.14e-01
p38MAPK events	12	8.31e-01	0.035700	9.20e-01
Death Receptor Signalling	122	4.98e-01	0.035600	7.01e-01
Nuclear Envelope Breakdown	48	6.71e-01	-0.035400	8.35e-01
Glutamate Neurotransmitter Release Cycle	17	8.01e-01	-0.035300	9.06e-01
Glycosphingolipid metabolism	34	7.22e-01	0.035200	8.61e-01
Mitochondrial translation elongation	85	5.77e-01	-0.035100	7.66e-01
Olfactory Signaling Pathway	14	8.21e-01	-0.035000	9.16e-01
Signal Transduction	1756	1.86e-02	-0.034900	8.88e-02
HIV Infection	205	3.91e-01	0.034800	5.99e-01
FCERI mediated MAPK activation	30	7.43e-01	0.034600	8.76e-01
Glutathione synthesis and recycling	10	8.50e-01	-0.034500	9.31e-01
RHO GTPases activate IQGAPs	10	8.51e-01	0.034400	9.31e-01
Signaling by GPCR	436	2.26e-01	-0.034000	4.45e-01
Scavenging by Class A Receptors	14	8.27e-01	-0.033700	9.20e-01
G alpha (q) signalling events	126	5.17e-01	0.033500	7.17e-01
Glutathione conjugation	29	7.56e-01	-0.033400	8.86e-01
Disorders of transmembrane transporters	128	5.17e-01	0.033200	7.17e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	8.20e-01	0.032900	9.16e-01
Interconversion of nucleotide di- and triphosphates	24	7.82e-01	0.032600	8.95e-01
Transcriptional Regulation by TP53	333	3.10e-01	0.032500	5.16e-01
Regulation of PLK1 Activity at G2/M Transition	84	6.08e-01	-0.032400	7.90e-01
Interleukin-4 and Interleukin-13 signaling	85	6.08e-01	0.032300	7.90e-01
PI Metabolism	79	6.21e-01	0.032200	7.97e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	6.11e-01	-0.032200	7.91e-01
O-linked glycosylation	71	6.44e-01	-0.031800	8.13e-01
Cell-Cell communication	81	6.24e-01	0.031500	8.00e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	31	7.64e-01	-0.031200	8.89e-01
RNA Polymerase I Transcription Termination	30	7.69e-01	-0.031000	8.89e-01
CD209 (DC-SIGN) signaling	19	8.16e-01	0.030900	9.16e-01
NOD1/2 Signaling Pathway	29	7.74e-01	-0.030800	8.91e-01
Retinoid metabolism and transport	27	7.84e-01	0.030500	8.96e-01
Recycling pathway of L1	27	7.84e-01	-0.030500	8.96e-01
Sema4D induced cell migration and growth-cone collapse	20	8.14e-01	0.030300	9.16e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	7.82e-01	0.030200	8.95e-01
Positive epigenetic regulation of rRNA expression	45	7.27e-01	0.030100	8.65e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	8.27e-01	-0.029800	9.20e-01
mTORC1-mediated signalling	23	8.06e-01	-0.029600	9.11e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	8.38e-01	-0.029500	9.23e-01
EPH-ephrin mediated repulsion of cells	43	7.38e-01	0.029500	8.71e-01
Repression of WNT target genes	11	8.66e-01	0.029300	9.39e-01
Intraflagellar transport	36	7.61e-01	-0.029300	8.89e-01
Activation of GABAB receptors	34	7.68e-01	-0.029200	8.89e-01
GABA B receptor activation	34	7.68e-01	-0.029200	8.89e-01
Interleukin-1 family signaling	115	5.91e-01	0.029100	7.80e-01
Pre-NOTCH Transcription and Translation	32	7.77e-01	-0.028900	8.92e-01
Erythropoietin activates RAS	13	8.60e-01	-0.028200	9.34e-01
Activation of SMO	14	8.56e-01	-0.028000	9.34e-01
Interleukin-37 signaling	18	8.38e-01	0.027900	9.23e-01
RNA Polymerase I Transcription Initiation	45	7.47e-01	-0.027800	8.78e-01
Acyl chain remodelling of PS	14	8.58e-01	-0.027600	9.34e-01
Initiation of Nuclear Envelope (NE) Reformation	19	8.36e-01	0.027400	9.22e-01
Serotonin Neurotransmitter Release Cycle	11	8.78e-01	-0.026800	9.44e-01
Triglyceride catabolism	15	8.58e-01	0.026700	9.34e-01
G alpha (s) signalling events	85	6.72e-01	-0.026600	8.35e-01
Extra-nuclear estrogen signaling	65	7.19e-01	0.025900	8.59e-01
Keratan sulfate degradation	10	8.88e-01	-0.025800	9.47e-01
Metabolism	1611	9.88e-02	0.025400	2.61e-01
APC/C:Cdc20 mediated degradation of Cyclin B	22	8.39e-01	-0.025100	9.23e-01
p75 NTR receptor-mediated signalling	84	6.92e-01	-0.025000	8.41e-01
Formation of TC-NER Pre-Incision Complex	50	7.60e-01	-0.025000	8.88e-01
G-protein activation	19	8.51e-01	0.024800	9.31e-01
NR1H2 and NR1H3-mediated signaling	37	7.94e-01	-0.024800	9.03e-01
COPI-dependent Golgi-to-ER retrograde traffic	75	7.15e-01	-0.024400	8.59e-01
Regulation of TP53 Activity through Phosphorylation	87	6.97e-01	0.024200	8.44e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	8.90e-01	0.024000	9.48e-01
Laminin interactions	22	8.46e-01	-0.024000	9.29e-01
Synthesis of PIPs at the plasma membrane	51	7.69e-01	-0.023800	8.89e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	39	7.98e-01	0.023800	9.04e-01
Signaling by RAS mutants	39	7.98e-01	0.023800	9.04e-01
Signaling by moderate kinase activity BRAF mutants	39	7.98e-01	0.023800	9.04e-01
Signaling downstream of RAS mutants	39	7.98e-01	0.023800	9.04e-01
Class I MHC mediated antigen processing & presentation	324	4.65e-01	0.023700	6.72e-01
Advanced glycosylation endproduct receptor signaling	10	8.97e-01	0.023700	9.49e-01
Chaperonin-mediated protein folding	81	7.21e-01	-0.023000	8.60e-01
SARS-CoV Infections	77	7.29e-01	-0.022900	8.66e-01
Extracellular matrix organization	223	5.59e-01	-0.022800	7.47e-01
AURKA Activation by TPX2	71	7.46e-01	0.022300	8.78e-01
PIP3 activates AKT signaling	238	5.57e-01	-0.022200	7.46e-01
Regulation of RUNX1 Expression and Activity	17	8.75e-01	0.022100	9.43e-01
Signaling by Non-Receptor Tyrosine Kinases	49	7.90e-01	-0.022100	8.99e-01
Signaling by PTK6	49	7.90e-01	-0.022100	8.99e-01
Inwardly rectifying K+ channels	25	8.53e-01	0.021500	9.31e-01
Regulation of TP53 Activity	148	6.54e-01	-0.021400	8.21e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	9.00e-01	-0.020900	9.51e-01
RA biosynthesis pathway	13	8.96e-01	0.020900	9.49e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	14	8.94e-01	-0.020600	9.49e-01
ADP signalling through P2Y purinoceptor 1	21	8.71e-01	0.020500	9.41e-01
RUNX2 regulates osteoblast differentiation	22	8.68e-01	-0.020400	9.40e-01
SUMOylation of intracellular receptors	26	8.58e-01	0.020300	9.34e-01
Mitotic Prophase	77	7.59e-01	-0.020200	8.88e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	38	8.30e-01	-0.020200	9.20e-01
B-WICH complex positively regulates rRNA expression	32	8.44e-01	0.020000	9.28e-01
Interleukin-7 signaling	20	8.79e-01	0.019600	9.44e-01
SLC-mediated transmembrane transport	158	6.73e-01	0.019500	8.35e-01
Negative regulation of the PI3K/AKT network	91	7.50e-01	-0.019400	8.80e-01
HIV elongation arrest and recovery	28	8.60e-01	0.019300	9.34e-01
Pausing and recovery of HIV elongation	28	8.60e-01	0.019300	9.34e-01
Processing of SMDT1	15	8.97e-01	-0.019200	9.49e-01
Synthesis of PIPs at the Golgi membrane	15	8.99e-01	-0.019000	9.50e-01
ECM proteoglycans	42	8.32e-01	-0.018900	9.20e-01
Binding and Uptake of Ligands by Scavenger Receptors	33	8.51e-01	0.018900	9.31e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	8.06e-01	0.018800	9.11e-01
Phosphorylation of the APC/C	20	8.87e-01	-0.018400	9.46e-01
Nitric oxide stimulates guanylate cyclase	19	8.91e-01	0.018200	9.48e-01
RNA Polymerase I Promoter Clearance	48	8.28e-01	-0.018200	9.20e-01
Signal transduction by L1	21	8.86e-01	0.018100	9.46e-01
Integrin signaling	24	8.78e-01	0.018100	9.44e-01
Metabolism of proteins	1574	2.55e-01	-0.017700	4.72e-01
ISG15 antiviral mechanism	62	8.10e-01	0.017600	9.14e-01
Anchoring of the basal body to the plasma membrane	92	7.71e-01	-0.017600	8.89e-01
Rho GTPase cycle	129	7.34e-01	0.017400	8.70e-01
APC-Cdc20 mediated degradation of Nek2A	24	8.84e-01	-0.017200	9.45e-01
Signaling by Retinoic Acid	32	8.67e-01	-0.017200	9.39e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	8.75e-01	0.017100	9.43e-01
Association of TriC/CCT with target proteins during biosynthesis	36	8.60e-01	-0.017000	9.34e-01
G alpha (i) signalling events	209	6.78e-01	-0.016700	8.35e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	9.08e-01	-0.016700	9.57e-01
ADORA2B mediated anti-inflammatory cytokines production	61	8.23e-01	-0.016600	9.17e-01
Epigenetic regulation of gene expression	84	7.98e-01	0.016200	9.04e-01
Assembly of collagen fibrils and other multimeric structures	47	8.49e-01	-0.016100	9.31e-01
DNA Damage Recognition in GG-NER	35	8.71e-01	-0.015900	9.41e-01
Carnitine metabolism	12	9.24e-01	-0.015800	9.72e-01
Regulation of TP53 Activity through Acetylation	29	8.83e-01	0.015800	9.45e-01
Signal amplification	29	8.83e-01	0.015800	9.45e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	26	8.92e-01	-0.015300	9.49e-01
Signaling by Erythropoietin	24	8.97e-01	-0.015300	9.49e-01
CS/DS degradation	10	9.33e-01	-0.015300	9.76e-01
Recruitment of NuMA to mitotic centrosomes	79	8.17e-01	-0.015100	9.16e-01
p75NTR recruits signalling complexes	11	9.32e-01	-0.014900	9.76e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	8.94e-01	-0.014800	9.49e-01
G alpha (z) signalling events	40	8.73e-01	-0.014600	9.42e-01
Methylation	11	9.33e-01	-0.014500	9.76e-01
FLT3 Signaling	246	6.96e-01	-0.014500	8.44e-01
Mitochondrial iron-sulfur cluster biogenesis	12	9.31e-01	-0.014500	9.76e-01
Protein folding	87	8.21e-01	-0.014100	9.16e-01
GPCR downstream signalling	404	6.32e-01	-0.014000	8.05e-01
Metabolism of fat-soluble vitamins	31	8.93e-01	0.014000	9.49e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	16	9.24e-01	0.013800	9.72e-01
mRNA Splicing - Minor Pathway	48	8.71e-01	-0.013600	9.41e-01
HATs acetylate histones	74	8.44e-01	-0.013300	9.28e-01
MAPK family signaling cascades	272	7.11e-01	-0.013100	8.57e-01
SUMOylation of transcription factors	15	9.31e-01	-0.012900	9.76e-01
Developmental Biology	679	5.75e-01	0.012800	7.66e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	9.41e-01	0.012300	9.79e-01
tRNA processing	107	8.31e-01	0.012000	9.20e-01
SUMOylation of immune response proteins	11	9.45e-01	-0.011900	9.79e-01
PPARA activates gene expression	108	8.33e-01	-0.011800	9.20e-01
Signaling by PDGFRA extracellular domain mutants	12	9.44e-01	0.011700	9.79e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	9.44e-01	0.011700	9.79e-01
Class I peroxisomal membrane protein import	19	9.32e-01	0.011300	9.76e-01
NRIF signals cell death from the nucleus	14	9.42e-01	-0.011300	9.79e-01
Activation of RAC1	12	9.46e-01	-0.011300	9.79e-01
Loss of Nlp from mitotic centrosomes	68	8.81e-01	-0.010500	9.44e-01
Loss of proteins required for interphase microtubule organization from the centrosome	68	8.81e-01	-0.010500	9.44e-01
Vitamin B5 (pantothenate) metabolism	15	9.44e-01	0.010500	9.79e-01
Trafficking of GluR2-containing AMPA receptors	15	9.45e-01	-0.010400	9.79e-01
Transcriptional regulation of white adipocyte differentiation	75	8.82e-01	-0.009970	9.44e-01
HDACs deacetylate histones	30	9.27e-01	0.009640	9.75e-01
RHO GTPases activate KTN1	10	9.58e-01	0.009560	9.83e-01
HS-GAG degradation	19	9.44e-01	0.009390	9.79e-01
Signal regulatory protein family interactions	13	9.54e-01	0.009310	9.82e-01
Cytosolic iron-sulfur cluster assembly	11	9.57e-01	0.009290	9.82e-01
Sema3A PAK dependent Axon repulsion	16	9.51e-01	-0.008950	9.81e-01
Signaling by Nuclear Receptors	199	8.30e-01	-0.008860	9.20e-01
MET activates RAS signaling	10	9.64e-01	0.008330	9.85e-01
O-glycosylation of TSR domain-containing proteins	33	9.39e-01	-0.007670	9.79e-01
RNA Polymerase III Transcription Initiation	36	9.38e-01	0.007530	9.78e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	9.62e-01	-0.007310	9.84e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	9.57e-01	-0.007080	9.82e-01
Synthesis of PE	11	9.68e-01	-0.007020	9.87e-01
Prefoldin mediated transfer of substrate to CCT/TriC	24	9.56e-01	0.006560	9.82e-01
Collagen biosynthesis and modifying enzymes	53	9.36e-01	-0.006350	9.77e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	38	9.47e-01	-0.006240	9.79e-01
Neddylation	210	8.77e-01	-0.006200	9.44e-01
RNA Polymerase II Transcription	980	7.52e-01	0.006050	8.83e-01
Generic Transcription Pathway	866	7.66e-01	0.006040	8.89e-01
SUMOylation of DNA damage response and repair proteins	66	9.34e-01	0.005930	9.76e-01
TRAF6 mediated NF-kB activation	22	9.64e-01	-0.005550	9.85e-01
Metabolism of lipids	574	8.23e-01	-0.005530	9.17e-01
Platelet homeostasis	71	9.36e-01	-0.005500	9.77e-01
Cytochrome c-mediated apoptotic response	10	9.77e-01	0.005340	9.89e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	13	9.74e-01	0.005160	9.88e-01
O-linked glycosylation of mucins	33	9.59e-01	-0.005120	9.83e-01
Endogenous sterols	18	9.71e-01	-0.005020	9.87e-01
Formation of Incision Complex in GG-NER	40	9.57e-01	-0.004920	9.82e-01
CTLA4 inhibitory signaling	21	9.69e-01	-0.004830	9.87e-01
Fatty acyl-CoA biosynthesis	24	9.69e-01	0.004620	9.87e-01
RNA Polymerase I Transcription	49	9.56e-01	-0.004550	9.82e-01
MAPK1/MAPK3 signaling	237	9.05e-01	0.004500	9.55e-01
CLEC7A (Dectin-1) induces NFAT activation	10	9.81e-01	-0.004430	9.90e-01
Signalling to RAS	18	9.74e-01	0.004430	9.88e-01
Carboxyterminal post-translational modifications of tubulin	26	9.70e-01	0.004230	9.87e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	9.79e-01	0.004130	9.89e-01
Antigen processing: Ubiquitination & Proteasome degradation	274	9.08e-01	-0.004090	9.57e-01
Interleukin-20 family signaling	15	9.79e-01	-0.003950	9.89e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	9.83e-01	0.003880	9.90e-01
alpha-linolenic acid (ALA) metabolism	10	9.83e-01	0.003880	9.90e-01
Hedgehog 'off' state	91	9.50e-01	0.003840	9.81e-01
Glycosaminoglycan metabolism	95	9.51e-01	0.003660	9.81e-01
Pausing and recovery of Tat-mediated HIV elongation	26	9.78e-01	-0.003170	9.89e-01
Tat-mediated HIV elongation arrest and recovery	26	9.78e-01	-0.003170	9.89e-01
DNA Double Strand Break Response	39	9.73e-01	0.003090	9.88e-01
Regulation of lipid metabolism by PPARalpha	110	9.57e-01	-0.003010	9.82e-01
Regulation of FOXO transcriptional activity by acetylation	10	9.88e-01	0.002840	9.92e-01
RAS processing	20	9.84e-01	0.002530	9.90e-01
PTEN Regulation	132	9.62e-01	0.002400	9.84e-01
Diseases associated with glycosaminoglycan metabolism	34	9.83e-01	-0.002050	9.90e-01
Rap1 signalling	15	9.91e-01	0.001620	9.93e-01
RAF/MAP kinase cascade	232	9.67e-01	0.001600	9.86e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	32	9.88e-01	-0.001560	9.92e-01
Centrosome maturation	80	9.84e-01	-0.001280	9.90e-01
Recruitment of mitotic centrosome proteins and complexes	80	9.84e-01	-0.001280	9.90e-01
Senescence-Associated Secretory Phenotype (SASP)	44	9.93e-01	-0.000795	9.93e-01
Collagen formation	73	9.97e-01	0.000254	9.97e-01
Gene expression (Transcription)	1098	9.90e-01	-0.000226	9.93e-01
Disease	1131	9.92e-01	-0.000174	9.93e-01

---

Detailed Gene set reports

Unwinding of DNA

Unwinding of DNA

	1274
set	Unwinding of DNA
setSize	12
pANOVA	2.24e-05
s.dist	0.707
p.adjustANOVA	0.000565

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM4	6536
MCM5	6469
MCM6	6247
MCM2	6028
MCM7	5848
MCM3	5675
GINS1	5600
GINS2	4898
GINS4	4092
CDC45	2952
MCM8	2187
GINS3	430

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM4	6536
MCM5	6469
MCM6	6247
MCM2	6028
MCM7	5848
MCM3	5675
GINS1	5600
GINS2	4898
GINS4	4092
CDC45	2952
MCM8	2187
GINS3	430

---

Classical antibody-mediated complement activation

Classical antibody-mediated complement activation

	189
set	Classical antibody-mediated complement activation
setSize	10
pANOVA	0.000173
s.dist	0.686
p.adjustANOVA	0.00299

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C1QA	6527.0
C1QB	6011.0
C1QC	5857.0
C1R	5595.0
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
IGKC	3217.0
C1S	-944.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C1QA	6527.0
C1QB	6011.0
C1QC	5857.0
C1R	5595.0
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
IGKC	3217.0
C1S	-944.0

---

Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

	797
set	Phosphorylation of CD3 and TCR zeta chains
setSize	11
pANOVA	0.000285
s.dist	0.632
p.adjustANOVA	0.00465

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTPRC	6344.0
PTPN22	5710.0
CD4	5297.0
PAG1	5228.0
LCK	5096.0
PTPRJ	4539.0
HLA-DQB1	4159.5
HLA-DQB2	4159.5
CD3D	3745.0
CSK	2264.0
CD247	297.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTPRC	6344.0
PTPN22	5710.0
CD4	5297.0
PAG1	5228.0
LCK	5096.0
PTPRJ	4539.0
HLA-DQB1	4159.5
HLA-DQB2	4159.5
CD3D	3745.0
CSK	2264.0
CD247	297.0

---

Interferon alpha/beta signaling

Interferon alpha/beta signaling

	531
set	Interferon alpha/beta signaling
setSize	45
pANOVA	5.91e-13
s.dist	0.62
p.adjustANOVA	1.97e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFIT3	6665.0
IFIT2	6637.0
MX1	6635.0
IRF7	6633.0
OAS1	6630.0
ISG15	6605.0
IRF9	6603.0
RSAD2	6590.0
BST2	6589.0
XAF1	6581.0
USP18	6569.5
IRF1	6531.0
PSMB8	6523.0
OASL	6498.0
IFITM1	6481.0
IFITM2	6481.0
IFITM3	6481.0
STAT2	6356.0
PTPN6	6351.0
STAT1	6274.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFIT3	6665.0
IFIT2	6637.0
MX1	6635.0
IRF7	6633.0
OAS1	6630.0
ISG15	6605.0
IRF9	6603.0
RSAD2	6590.0
BST2	6589.0
XAF1	6581.0
USP18	6569.5
IRF1	6531.0
PSMB8	6523.0
OASL	6498.0
IFITM1	6481.0
IFITM2	6481.0
IFITM3	6481.0
STAT2	6356.0
PTPN6	6351.0
STAT1	6274.0
OAS2	6253.0
TYK2	5493.0
SOCS1	5441.0
IFI35	5402.0
IRF8	5344.0
OAS3	5317.0
IRF5	5104.0
IFNAR1	5048.0
IRF3	4925.0
SAMHD1	4420.0
SOCS3	4310.0
RNASEL	3643.0
IRF4	3219.0
IFI27	1872.0
IRF6	1814.0
ADAR	1746.0
PTPN1	1428.0
IP6K2	1065.0
IRF2	687.0
ISG20	514.0
IFNAR2	268.0
ABCE1	-2485.0
JAK1	-2792.0
PTPN11	-5252.0
EGR1	-5733.0

---

Initial triggering of complement

Initial triggering of complement

	514
set	Initial triggering of complement
setSize	19
pANOVA	3.48e-06
s.dist	0.615
p.adjustANOVA	0.000111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CFB	6648.0
C2	6588.0
C1QA	6527.0
COLEC11	6431.0
C4A	6371.5
C4B	6371.5
C3	6314.0
C1QB	6011.0
C1QC	5857.0
C1R	5595.0
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
GZMM	4235.0
IGKC	3217.0
C1S	-944.0
MASP1	-5051.0
CFD	-5279.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CFB	6648.0
C2	6588.0
C1QA	6527.0
COLEC11	6431.0
C4A	6371.5
C4B	6371.5
C3	6314.0
C1QB	6011.0
C1QC	5857.0
C1R	5595.0
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
GZMM	4235.0
IGKC	3217.0
C1S	-944.0
MASP1	-5051.0
CFD	-5279.0

---

LGI-ADAM interactions

LGI-ADAM interactions

	572
set	LGI-ADAM interactions
setSize	11
pANOVA	0.000543
s.dist	-0.602
p.adjustANOVA	0.00734

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LGI1	-6205
LGI4	-6058
ADAM11	-5956
STX1B	-5564
LGI2	-4965
ADAM23	-3776
LGI3	-3642
ADAM22	-2212
CACNG2	-1679
STX1A	-1519
DLG4	-345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LGI1	-6205
LGI4	-6058
ADAM11	-5956
STX1B	-5564
LGI2	-4965
ADAM23	-3776
LGI3	-3642
ADAM22	-2212
CACNG2	-1679
STX1A	-1519
DLG4	-345

---

Creation of C4 and C2 activators

Creation of C4 and C2 activators

	216
set	Creation of C4 and C2 activators
setSize	12
pANOVA	0.000439
s.dist	0.586
p.adjustANOVA	0.00627

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C1QA	6527.0
COLEC11	6431.0
C1QB	6011.0
C1QC	5857.0
C1R	5595.0
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
IGKC	3217.0
C1S	-944.0
MASP1	-5051.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C1QA	6527.0
COLEC11	6431.0
C1QB	6011.0
C1QC	5857.0
C1R	5595.0
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
IGKC	3217.0
C1S	-944.0
MASP1	-5051.0

---

Peptide chain elongation

Peptide chain elongation

	786
set	Peptide chain elongation
setSize	55
pANOVA	1.57e-13
s.dist	0.575
p.adjustANOVA	9.73e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EEF1A1	6341
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EEF1A1	6341
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
RPS27A	3675
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
RPS26	1816
RPL26	1693
RPL28	811
RPS29	193
EEF2	77
RPL3L	-1683

---

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

	703
set	Negative regulation of TCF-dependent signaling by WNT ligand antagonists
setSize	11
pANOVA	0.00119
s.dist	-0.565
p.adjustANOVA	0.0138

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KREMEN1	-6360.0
WIF1	-6357.0
SOST	-6215.0
LRP5	-6064.5
WNT5A	-5440.0
WNT9A	-4877.0
LRP6	-4726.0
SFRP2	-1464.0
SFRP1	-114.0
WNT4	1108.0
KREMEN2	1294.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KREMEN1	-6360.0
WIF1	-6357.0
SOST	-6215.0
LRP5	-6064.5
WNT5A	-5440.0
WNT9A	-4877.0
LRP6	-4726.0
SFRP2	-1464.0
SFRP1	-114.0
WNT4	1108.0
KREMEN2	1294.0

---

Selenocysteine synthesis

Selenocysteine synthesis

	1033
set	Selenocysteine synthesis
setSize	58
pANOVA	2.19e-13
s.dist	0.557
p.adjustANOVA	9.73e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSTK	6190
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSTK	6190
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
RPS27A	3675
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
EEFSEC	2954
RPS23	2821
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
RPS26	1816
RPL26	1693
SECISBP2	1511
SEPSECS	1085
RPL28	811
RPS29	193
SEPHS2	-682
RPL3L	-1683

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	982
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	65
pANOVA	1.04e-14
s.dist	0.555
p.adjustANOVA	1.39e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DDIT3	6586
TRIB3	6542
ASNS	6322
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
EIF2AK4	4992
RPS18	4951

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DDIT3	6586
TRIB3	6542
ASNS	6322
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
EIF2AK4	4992
RPS18	4951
RPL30	4938
RPL23	4933
ATF4	4922
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
CEBPB	4504
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
EIF2S1	3690
RPS27A	3675
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
EIF2S2	2646
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
ATF2	2063
RPS14	1909
RPS26	1816
RPL26	1693
CEBPG	1563
RPL28	811
RPS29	193
RPL3L	-1683
IMPACT	-3382
ATF3	-4181

---

Viral mRNA Translation

Viral mRNA Translation

	1285
set	Viral mRNA Translation
setSize	55
pANOVA	2.13e-12
s.dist	0.548
p.adjustANOVA	5.69e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
RPS27A	3675
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
RPS26	1816
RPL26	1693
RPL28	811
RPS29	193
DNAJC3	-1477
RPL3L	-1683
GRSF1	-2013

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	202
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	0.00185
s.dist	0.542
p.adjustANOVA	0.0179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMC2	6323.0
NCAPH	5987.0
NCAPG	5926.0
CCNB1	5801.0
SMC4	5778.0
CDK1	4567.0
NCAPD2	4542.0
CCNB2	3128.0
CSNK2A2	2995.0
CSNK2B	-94.5
CSNK2A1	-4572.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMC2	6323.0
NCAPH	5987.0
NCAPG	5926.0
CCNB1	5801.0
SMC4	5778.0
CDK1	4567.0
NCAPD2	4542.0
CCNB2	3128.0
CSNK2A2	2995.0
CSNK2B	-94.5
CSNK2A1	-4572.0

---

DNA strand elongation

DNA strand elongation

	244
set	DNA strand elongation
setSize	32
pANOVA	1.25e-07
s.dist	0.54
p.adjustANOVA	4.87e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM4	6536
MCM5	6469
MCM6	6247
POLA1	6186
MCM2	6028
LIG1	5975
MCM7	5848
PCNA	5717
MCM3	5675
POLD4	5634
GINS1	5600
GINS2	4898
FEN1	4429
RPA2	4286
GINS4	4092
PRIM1	4045
POLD2	3892
RFC2	3753
POLD3	3547
DNA2	3229

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM4	6536
MCM5	6469
MCM6	6247
POLA1	6186
MCM2	6028
LIG1	5975
MCM7	5848
PCNA	5717
MCM3	5675
POLD4	5634
GINS1	5600
GINS2	4898
FEN1	4429
RPA2	4286
GINS4	4092
PRIM1	4045
POLD2	3892
RFC2	3753
POLD3	3547
DNA2	3229
RPA3	3116
CDC45	2952
MCM8	2187
RFC3	2097
RFC5	2053
POLD1	2030
POLA2	1920
RFC4	745
RPA1	565
GINS3	430
RFC1	-761
PRIM2	-2590

---

Glucuronidation

Glucuronidation

	439
set	Glucuronidation
setSize	11
pANOVA	0.00269
s.dist	0.523
p.adjustANOVA	0.0224

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UGT3A1	6613.5
UGT3A2	6613.5
UGT1A10	5386.5
UGT1A7	5386.5
UGT1A8	5386.5
UGT1A9	5386.5
SLC35D1	3353.0
UGT1A6	2973.0
UGP2	1148.0
ABHD10	-731.0
UGDH	-2531.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UGT3A1	6613.5
UGT3A2	6613.5
UGT1A10	5386.5
UGT1A7	5386.5
UGT1A8	5386.5
UGT1A9	5386.5
SLC35D1	3353.0
UGT1A6	2973.0
UGP2	1148.0
ABHD10	-731.0
UGDH	-2531.0

---

PI-3K cascade:FGFR2

PI-3K cascade:FGFR2

	762
set	PI-3K cascade:FGFR2
setSize	14
pANOVA	0.000759
s.dist	-0.52
p.adjustANOVA	0.00929

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	-6071
GAB1	-5997
FGF2	-5365
PTPN11	-5252
FGFR2	-5015
FGF1	-4776
FGF9	-4745
FRS2	-4514
FGF18	-3601
FGF10	-2626
FGF7	-2280
PIK3CA	-1782
FGF16	-167
PIK3R1	6390

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	-6071
GAB1	-5997
FGF2	-5365
PTPN11	-5252
FGFR2	-5015
FGF1	-4776
FGF9	-4745
FRS2	-4514
FGF18	-3601
FGF10	-2626
FGF7	-2280
PIK3CA	-1782
FGF16	-167
PIK3R1	6390

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	341
set	Eukaryotic Translation Elongation
setSize	59
pANOVA	5.35e-12
s.dist	0.519
p.adjustANOVA	1.02e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EEF1A1	6341
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EEF1A1	6341
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
EEF1B2	3924
RPS11	3869
RPS3	3755
RPS27A	3675
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
RPS26	1816
RPL26	1693
RPL28	811
RPS29	193
EEF2	77
RPL3L	-1683
EEF1G	-1703
EEF1D	-2186
EEF1A2	-6200

---

PI-3K cascade:FGFR4

PI-3K cascade:FGFR4

	764
set	PI-3K cascade:FGFR4
setSize	11
pANOVA	0.00292
s.dist	-0.518
p.adjustANOVA	0.0239

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	-6071
GAB1	-5997
FGF2	-5365
PTPN11	-5252
FGF1	-4776
FGF9	-4745
FRS2	-4514
FGF18	-3601
PIK3CA	-1782
FGF16	-167
PIK3R1	6390

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	-6071
GAB1	-5997
FGF2	-5365
PTPN11	-5252
FGF1	-4776
FGF9	-4745
FRS2	-4514
FGF18	-3601
PIK3CA	-1782
FGF16	-167
PIK3R1	6390

---

Processive synthesis on the lagging strand

Processive synthesis on the lagging strand

	835
set	Processive synthesis on the lagging strand
setSize	15
pANOVA	0.000615
s.dist	0.511
p.adjustANOVA	0.00821

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLA1	6186
LIG1	5975
PCNA	5717
POLD4	5634
FEN1	4429
RPA2	4286
PRIM1	4045
POLD2	3892
POLD3	3547
DNA2	3229
RPA3	3116
POLD1	2030
POLA2	1920
RPA1	565
PRIM2	-2590

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLA1	6186
LIG1	5975
PCNA	5717
POLD4	5634
FEN1	4429
RPA2	4286
PRIM1	4045
POLD2	3892
POLD3	3547
DNA2	3229
RPA3	3116
POLD1	2030
POLA2	1920
RPA1	565
PRIM2	-2590

---

Glycogen storage diseases

Glycogen storage diseases

	448
set	Glycogen storage diseases
setSize	11
pANOVA	0.00345
s.dist	-0.509
p.adjustANOVA	0.0273

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBC	-6387
PPP1R3C	-6187
GYS1	-6158
G6PC3	-5056
GAA	-4725
GBE1	-4666
NHLRC1	-3711
EPM2A	-2567
GYG1	-1137
SLC37A4	1679
RPS27A	3675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBC	-6387
PPP1R3C	-6187
GYS1	-6158
G6PC3	-5056
GAA	-4725
GBE1	-4666
NHLRC1	-3711
EPM2A	-2567
GYG1	-1137
SLC37A4	1679
RPS27A	3675

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	343
set	Eukaryotic Translation Termination
setSize	58
pANOVA	2.1e-11
s.dist	0.509
p.adjustANOVA	2.55e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
RPS27A	3675
N6AMT1	3408
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
RPS26	1816
RPL26	1693
RPL28	811
RPS29	193
GSPT2	52
RPL3L	-1683
ETF1	-2153
GSPT1	-3600
APEH	-4922

---

FCGR activation

FCGR activation

	352
set	FCGR activation
setSize	16
pANOVA	0.000438
s.dist	0.508
p.adjustANOVA	0.00627

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HCK	6389.0
FCGR1A	6296.5
LYN	5842.0
FGR	5417.0
FCGR3A	5113.5
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
FCGR2A	4476.5
IGKC	3217.0
FYN	2275.0
SRC	938.0
CD247	297.0
YES1	34.0
SYK	-5026.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HCK	6389.0
FCGR1A	6296.5
LYN	5842.0
FGR	5417.0
FCGR3A	5113.5
IGHG1	4963.5
IGHG2	4963.5
IGHG3	4963.5
IGHG4	4963.5
FCGR2A	4476.5
IGKC	3217.0
FYN	2275.0
SRC	938.0
CD247	297.0
YES1	34.0
SYK	-5026.0

---

Cholesterol biosynthesis

Cholesterol biosynthesis

	176
set	Cholesterol biosynthesis
setSize	23
pANOVA	2.98e-05
s.dist	-0.503
p.adjustANOVA	0.000685

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDI1	-5657
SC5D	-5633
MSMO1	-5379
CYP51A1	-5367
DHCR24	-5206
HMGCS1	-5182
SQLE	-4781
MVK	-4623
MVD	-4562
EBP	-4288
PMVK	-4113
HSD17B7	-3902
ACAT2	-3743
GGPS1	-3431
NSDHL	-3430
FDPS	-3292
TM7SF2	-1617
HMGCR	-1370
DHCR7	-1005
LBR	-982

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDI1	-5657
SC5D	-5633
MSMO1	-5379
CYP51A1	-5367
DHCR24	-5206
HMGCS1	-5182
SQLE	-4781
MVK	-4623
MVD	-4562
EBP	-4288
PMVK	-4113
HSD17B7	-3902
ACAT2	-3743
GGPS1	-3431
NSDHL	-3430
FDPS	-3292
TM7SF2	-1617
HMGCR	-1370
DHCR7	-1005
LBR	-982
LSS	-368
ARV1	1454
FDFT1	3817

---

Signaling by Activin

Signaling by Activin

	1046
set	Signaling by Activin
setSize	11
pANOVA	0.0045
s.dist	-0.495
p.adjustANOVA	0.0321

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMAD3	-6395
INHBB	-6385
ACVR2B	-5399
ACVR2A	-4836
FST	-4285
ACVR1B	-3649
INHBA	-2533
SMAD4	-1563
SMAD2	-1334
DRAP1	-485
FSTL3	2672

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMAD3	-6395
INHBB	-6385
ACVR2B	-5399
ACVR2A	-4836
FST	-4285
ACVR1B	-3649
INHBA	-2533
SMAD4	-1563
SMAD2	-1334
DRAP1	-485
FSTL3	2672

---

Regulation of IFNA signaling

Regulation of IFNA signaling

	930
set	Regulation of IFNA signaling
setSize	12
pANOVA	0.00369
s.dist	0.484
p.adjustANOVA	0.0285

Top enriched genes

Top 20 genes

GeneID	Gene Rank
USP18	6569.5
STAT2	6356.0
PTPN6	6351.0
STAT1	6274.0
TYK2	5493.0
SOCS1	5441.0
IFNAR1	5048.0
SOCS3	4310.0
PTPN1	1428.0
IFNAR2	268.0
JAK1	-2792.0
PTPN11	-5252.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
USP18	6569.5
STAT2	6356.0
PTPN6	6351.0
STAT1	6274.0
TYK2	5493.0
SOCS1	5441.0
IFNAR1	5048.0
SOCS3	4310.0
PTPN1	1428.0
IFNAR2	268.0
JAK1	-2792.0
PTPN11	-5252.0

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

	53
set	Activation of the pre-replicative complex
setSize	31
pANOVA	3.2e-06
s.dist	0.483
p.adjustANOVA	0.000104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM4	6536
MCM5	6469
MCM6	6247
POLA1	6186
MCM2	6028
CDT1	5968
MCM7	5848
MCM3	5675
POLE	5568
CDK2	5364
POLE3	4666
MCM10	4512
ORC6	4362
RPA2	4286
PRIM1	4045
CDC6	3683
DBF4	3656
ORC5	3411
RPA3	3116
CDC45	2952

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM4	6536
MCM5	6469
MCM6	6247
POLA1	6186
MCM2	6028
CDT1	5968
MCM7	5848
MCM3	5675
POLE	5568
CDK2	5364
POLE3	4666
MCM10	4512
ORC6	4362
RPA2	4286
PRIM1	4045
CDC6	3683
DBF4	3656
ORC5	3411
RPA3	3116
CDC45	2952
ORC2	2336
MCM8	2187
POLA2	1920
POLE2	1685
CDC7	1434
ORC3	676
RPA1	565
POLE4	255
GMNN	-1938
PRIM2	-2590
ORC4	-3354

---

Removal of the Flap Intermediate

Removal of the Flap Intermediate

	969
set	Removal of the Flap Intermediate
setSize	14
pANOVA	0.00174
s.dist	0.483
p.adjustANOVA	0.0173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLA1	6186
PCNA	5717
POLD4	5634
FEN1	4429
RPA2	4286
PRIM1	4045
POLD2	3892
POLD3	3547
DNA2	3229
RPA3	3116
POLD1	2030
POLA2	1920
RPA1	565
PRIM2	-2590

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLA1	6186
PCNA	5717
POLD4	5634
FEN1	4429
RPA2	4286
PRIM1	4045
POLD2	3892
POLD3	3547
DNA2	3229
RPA3	3116
POLD1	2030
POLA2	1920
RPA1	565
PRIM2	-2590

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	381
set	Formation of a pool of free 40S subunits
setSize	65
pANOVA	5.29e-11
s.dist	0.471
p.adjustANOVA	5.43e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL11	6051.0
RPS15A	5982.0
RPL15	5940.0
RPS9	5715.0
RPLP2	5666.0
RPS27L	5648.0
RPL22L1	5575.0
RPS24	5481.0
RPL3	5445.0
RPL18A	5312.0
RPS8	5269.0
RPS4X	5238.0
RPL10	5221.0
RPL36A	5189.0
RPS16	5049.0
RPS18	4951.0
RPL30	4938.0
RPL23	4933.0
RPS27	4820.0
RPL38	4766.0
RPS20	4641.0
RPS19	4592.0
RPL4	4575.0
RPL32	4479.0
RPS12	4369.0
EIF3E	4262.0
RPS5	4221.0
RPS13	4118.0
FAU	4042.0
RPL19	4026.0
RPL37	4012.0
RPS11	3869.0
RPS3	3755.0
RPS27A	3675.0
EIF3H	3543.0
RPL34	3338.0
RPL31	3304.0
RPS15	3273.0
RPL35A	3238.0
RPL7	3132.0
RPL37A	3126.0
RPS21	3110.0
RPL8	3017.0
RPL18	2994.0
RPS23	2821.0
RPS6	2632.0
EIF3M	2518.0
RPL5	2246.0
RPL22	2123.0
RPL14	2066.0
RPS14	1909.0
RPS26	1816.0
RPL26	1693.0
RPL28	811.0
EIF3F	563.0
EIF3G	273.0
RPS29	193.0
EIF3B	-667.0
EIF3I	-757.0
EIF3A	-930.0
EIF3C	-1448.5
RPL3L	-1683.0
EIF3D	-2078.0
EIF3L	-2101.0
EIF3K	-2420.0

---

Generation of second messenger molecules

Generation of second messenger molecules

	431
set	Generation of second messenger molecules
setSize	22
pANOVA	0.00015
s.dist	0.467
p.adjustANOVA	0.00271

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FYB	6367.0
WAS	5667.0
CD4	5297.0
LAT	5111.0
LCK	5096.0
GRAP2	4882.0
ITK	4459.0
HLA-DQB1	4159.5
HLA-DQB2	4159.5
LCP2	4135.0
CD3D	3745.0
EVL	3658.0
CD101	3544.0
PAK3	2634.0
VASP	2602.0
NCK1	2598.0
PAK2	2475.0
PAK1	1647.0
PLCG1	694.0
PLCG2	680.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FYB	6367.0
WAS	5667.0
CD4	5297.0
LAT	5111.0
LCK	5096.0
GRAP2	4882.0
ITK	4459.0
HLA-DQB1	4159.5
HLA-DQB2	4159.5
LCP2	4135.0
CD3D	3745.0
EVL	3658.0
CD101	3544.0
PAK3	2634.0
VASP	2602.0
NCK1	2598.0
PAK2	2475.0
PAK1	1647.0
PLCG1	694.0
PLCG2	680.0
CD247	297.0
ENAH	-4008.0

---

PD-1 signaling

PD-1 signaling

	757
set	PD-1 signaling
setSize	10
pANOVA	0.0113
s.dist	0.463
p.adjustANOVA	0.0603

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTPN6	6351.0
CD274	5419.0
CD4	5297.0
LCK	5096.0
HLA-DQB1	4159.5
HLA-DQB2	4159.5
CD3D	3745.0
CSK	2264.0
CD247	297.0
PTPN11	-5252.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTPN6	6351.0
CD274	5419.0
CD4	5297.0
LCK	5096.0
HLA-DQB1	4159.5
HLA-DQB2	4159.5
CD3D	3745.0
CSK	2264.0
CD247	297.0
PTPN11	-5252.0

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	722
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	60
pANOVA	7.23e-10
s.dist	0.46
p.adjustANOVA	4.83e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
RPS27A	3675
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
RPS6	2632
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
RPS26	1816
RPL26	1693
RPL28	811
UPF1	705
RPS29	193
GSPT2	52
RPL3L	-1683
ETF1	-2153
GSPT1	-3600
NCBP1	-3939
EIF4G1	-4661
NCBP2	-5760

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1032
set	Selenoamino acid metabolism
setSize	71
pANOVA	3.03e-11
s.dist	0.456
p.adjustANOVA	3.37e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSTK	6190
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
GNMT	5375
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
RPS18	4951
RPL30	4938
RPL23	4933

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSTK	6190.0
RPL11	6051.0
RPS15A	5982.0
RPL15	5940.0
RPS9	5715.0
RPLP2	5666.0
RPS27L	5648.0
RPL22L1	5575.0
RPS24	5481.0
RPL3	5445.0
GNMT	5375.0
RPL18A	5312.0
RPS8	5269.0
RPS4X	5238.0
RPL10	5221.0
RPL36A	5189.0
RPS16	5049.0
RPS18	4951.0
RPL30	4938.0
RPL23	4933.0
RPS27	4820.0
NNMT	4769.0
RPL38	4766.0
RPS20	4641.0
RPS19	4592.0
RPL4	4575.0
RPL32	4479.0
RPS12	4369.0
PAPSS2	4228.0
RPS5	4221.0
RPS13	4118.0
FAU	4042.0
RPL19	4026.0
RPL37	4012.0
RPS11	3869.0
RPS3	3755.0
RPS27A	3675.0
CTH	3546.0
RPL34	3338.0
RPL31	3304.0
AIMP1	3287.0
RPS15	3273.0
RPL35A	3238.0
RPL7	3132.0
RPL37A	3126.0
RPS21	3110.0
RPL8	3017.0
RPL18	2994.0
EEFSEC	2954.0
RPS23	2821.0
RPS6	2632.0
PAPSS1	2318.0
RPL5	2246.0
RPL22	2123.0
RPL14	2066.0
RPS14	1909.0
RPS26	1816.0
RPL26	1693.0
SECISBP2	1511.0
AIMP2	1094.0
SEPSECS	1085.0
RPL28	811.0
RPS29	193.0
SEPHS2	-682.0
EEF1E1	-1386.5
RPL3L	-1683.0
GSR	-2301.0
SCLY	-2384.0
HNMT	-4461.0
TXNRD1	-5690.0
AHCY	-6380.0

---

HSF1-dependent transactivation

HSF1-dependent transactivation

	475
set	HSF1-dependent transactivation
setSize	32
pANOVA	8.51e-06
s.dist	-0.455
p.adjustANOVA	0.000232

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CAMK2B	-6150.0
HSPA1A	-6137.5
HSPA1B	-6137.5
CAMK2G	-6034.0
HSPB8	-6010.0
RPTOR	-5946.0
HSF1	-5815.0
FKBP4	-5809.0
HSP90AB1	-5086.0
SERPINH1	-4875.0
HSPH1	-4840.0
HSP90AA1	-4446.0
MLST8	-4401.0
DNAJB1	-4400.0
EP300	-4399.0
HSPA8	-4221.0
DNAJB6	-4022.0
CAMK2D	-4012.0
CRYBA4	-3753.0
CAMK2A	-3729.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CAMK2B	-6150.0
HSPA1A	-6137.5
HSPA1B	-6137.5
CAMK2G	-6034.0
HSPB8	-6010.0
RPTOR	-5946.0
HSF1	-5815.0
FKBP4	-5809.0
HSP90AB1	-5086.0
SERPINH1	-4875.0
HSPH1	-4840.0
HSP90AA1	-4446.0
MLST8	-4401.0
DNAJB1	-4400.0
EP300	-4399.0
HSPA8	-4221.0
DNAJB6	-4022.0
CAMK2D	-4012.0
CRYBA4	-3753.0
CAMK2A	-3729.0
MTOR	-3383.0
HSBP1	-3164.0
COL4A6	-2648.0
HSPA1L	-2297.0
CRYAB	-468.0
AKT1S1	484.0
CREBBP	723.0
MRPL18	1602.0
PTGES3	2826.0
HSPA2	3765.0
DEDD2	5361.0
TNFRSF21	6465.0

---

FRS-mediated FGFR2 signaling

FRS-mediated FGFR2 signaling

	364
set	FRS-mediated FGFR2 signaling
setSize	16
pANOVA	0.00166
s.dist	-0.454
p.adjustANOVA	0.0168

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	-6071
FGF2	-5365
PTPN11	-5252
FGFR2	-5015
FGF1	-4776
FGF9	-4745
FRS2	-4514
SOS1	-4192
FGF18	-3601
FRS3	-3072
FGF10	-2626
FGF7	-2280
FGF16	-167
HRAS	314
KRAS	1682
NRAS	4196

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	-6071
FGF2	-5365
PTPN11	-5252
FGFR2	-5015
FGF1	-4776
FGF9	-4745
FRS2	-4514
SOS1	-4192
FGF18	-3601
FRS3	-3072
FGF10	-2626
FGF7	-2280
FGF16	-167
HRAS	314
KRAS	1682
NRAS	4196

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

	175
set	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize	12
pANOVA	0.00657
s.dist	0.453
p.adjustANOVA	0.0422

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WEE1	6501
CCNB1	5801
YWHAQ	5526
CHEK1	4584
CDK1	4567
YWHAB	3919
CHEK2	3341
YWHAZ	2463
YWHAH	2437
SFN	1458
YWHAE	1280
YWHAG	-4806

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WEE1	6501
CCNB1	5801
YWHAQ	5526
CHEK1	4584
CDK1	4567
YWHAB	3919
CHEK2	3341
YWHAZ	2463
YWHAH	2437
SFN	1458
YWHAE	1280
YWHAG	-4806

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1014
set	SRP-dependent cotranslational protein targeting to membrane
setSize	76
pANOVA	1.61e-11
s.dist	0.447
p.adjustANOVA	2.27e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SRP54	6302
SSR4	6122
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
SRP72	5328
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
SEC61G	5044
RPS18	4951

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SRP54	6302
SSR4	6122
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
SRP72	5328
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
SEC61G	5044
RPS18	4951
RPL30	4938
RPL23	4933
SEC11A	4921
RPS27	4820
TRAM1	4776
RPL38	4766
RPS20	4641
RPS19	4592
RPL4	4575
RPL32	4479
RPS12	4369
SEC61A1	4361
RPS5	4221
RPS13	4118
FAU	4042
RPL19	4026
RPL37	4012
RPS11	3869
RPS3	3755
RPS27A	3675
SRP19	3482
RPL34	3338
RPL31	3304
RPS15	3273
RPL35A	3238
RPL7	3132
RPL37A	3126
RPS21	3110
RPL8	3017
RPL18	2994
RPS23	2821
RPS6	2632
SPCS2	2629
SRP9	2470
RPL5	2246
RPL22	2123
RPL14	2066
RPS14	1909
SEC11C	1865
RPS26	1816
RPL26	1693
SPCS1	1219
RPL28	811
SRP68	327
RPS29	193
SEC61A2	108
SPCS3	-664
SRP14	-1412
RPL3L	-1683
SSR2	-2163
SSR3	-2465
SSR1	-2739
DDOST	-2982
RPN2	-3034
SRPRB	-4513
RPN1	-4983

---

G1/S-Specific Transcription

G1/S-Specific Transcription

	407
set	G1/S-Specific Transcription
setSize	26
pANOVA	8.73e-05
s.dist	0.445
p.adjustANOVA	0.00177

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FBXO5	6411
POLA1	6186
CDT1	5968
LIN52	5794
TFDP2	5729
PCNA	5717
TK1	5623
RBL1	5524
RRM2	5492
LIN9	4638
E2F1	4577
CDK1	4567
TYMS	4290
CCNE1	3709
CDC6	3683
RBL2	3404
RBBP4	3130
CDC25A	2955
CDC45	2952
LIN54	2297

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FBXO5	6411.0
POLA1	6186.0
CDT1	5968.0
LIN52	5794.0
TFDP2	5729.0
PCNA	5717.0
TK1	5623.0
RBL1	5524.0
RRM2	5492.0
LIN9	4638.0
E2F1	4577.0
CDK1	4567.0
TYMS	4290.0
CCNE1	3709.0
CDC6	3683.0
RBL2	3404.0
RBBP4	3130.0
CDC25A	2955.0
CDC45	2952.0
LIN54	2297.0
DHFR	2084.5
E2F5	-99.0
LIN37	-1656.0
E2F4	-3260.0
TFDP1	-4870.5
E2F6	-6062.0

---

Activated NTRK2 signals through FRS2 and FRS3

Activated NTRK2 signals through FRS2 and FRS3

	32
set	Activated NTRK2 signals through FRS2 and FRS3
setSize	10
pANOVA	0.0161
s.dist	-0.44
p.adjustANOVA	0.081

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDNF	-6093
GRB2	-6071
PTPN11	-5252
FRS2	-4514
NTRK2	-4480
SOS1	-4192
FRS3	-3072
HRAS	314
KRAS	1682
NRAS	4196

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDNF	-6093
GRB2	-6071
PTPN11	-5252
FRS2	-4514
NTRK2	-4480
SOS1	-4192
FRS3	-3072
HRAS	314
KRAS	1682
NRAS	4196

---

Lagging Strand Synthesis

Lagging Strand Synthesis

	573
set	Lagging Strand Synthesis
setSize	20
pANOVA	0.000683
s.dist	0.439
p.adjustANOVA	0.0086

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLA1	6186
LIG1	5975
PCNA	5717
POLD4	5634
FEN1	4429
RPA2	4286
PRIM1	4045
POLD2	3892
RFC2	3753
POLD3	3547
DNA2	3229
RPA3	3116
RFC3	2097
RFC5	2053
POLD1	2030
POLA2	1920
RFC4	745
RPA1	565
RFC1	-761
PRIM2	-2590

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLA1	6186
LIG1	5975
PCNA	5717
POLD4	5634
FEN1	4429
RPA2	4286
PRIM1	4045
POLD2	3892
RFC2	3753
POLD3	3547
DNA2	3229
RPA3	3116
RFC3	2097
RFC5	2053
POLD1	2030
POLA2	1920
RFC4	745
RPA1	565
RFC1	-761
PRIM2	-2590

---

Activation of AMPK downstream of NMDARs

Activation of AMPK downstream of NMDARs

	33
set	Activation of AMPK downstream of NMDARs
setSize	10
pANOVA	0.0163
s.dist	-0.439
p.adjustANOVA	0.0818

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKAA2	-6217
MAPT	-5858
PRKAB2	-5816
PRKAG2	-5299
PRKAB1	-5040
PRKAG3	-4646
PRKAG1	-524
PRKAA1	-68
CAMKK2	2606
CALM1	3439

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKAA2	-6217
MAPT	-5858
PRKAB2	-5816
PRKAG2	-5299
PRKAB1	-5040
PRKAG3	-4646
PRKAG1	-524
PRKAA1	-68
CAMKK2	2606
CALM1	3439

---

Removal of the Flap Intermediate from the C-strand

Removal of the Flap Intermediate from the C-strand

	970
set	Removal of the Flap Intermediate from the C-strand
setSize	17
pANOVA	0.00175
s.dist	0.438
p.adjustANOVA	0.0173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TINF2	5918
PCNA	5717
POLD4	5634
TERF1	5489
FEN1	4429
RPA2	4286
POLD2	3892
POLD3	3547
DNA2	3229
TERF2	3225
RPA3	3116
POLD1	2030
POT1	1510
RPA1	565
TERF2IP	534
WRN	-292
ACD	-1960

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TINF2	5918
PCNA	5717
POLD4	5634
TERF1	5489
FEN1	4429
RPA2	4286
POLD2	3892
POLD3	3547
DNA2	3229
TERF2	3225
RPA3	3116
POLD1	2030
POT1	1510
RPA1	565
TERF2IP	534
WRN	-292
ACD	-1960

---

STING mediated induction of host immune responses

STING mediated induction of host immune responses

	1015
set	STING mediated induction of host immune responses
setSize	12
pANOVA	0.00854
s.dist	0.438
p.adjustANOVA	0.0496

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFI16	6666.5
TRIM21	6195.0
TREX1	5480.0
IRF3	4925.0
TBK1	4375.0
DDX41	4154.0
PRKDC	3375.0
NLRC3	2997.0
XRCC5	2957.0
STAT6	1234.0
XRCC6	-140.0
DTX4	-6299.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFI16	6666.5
TRIM21	6195.0
TREX1	5480.0
IRF3	4925.0
TBK1	4375.0
DDX41	4154.0
PRKDC	3375.0
NLRC3	2997.0
XRCC5	2957.0
STAT6	1234.0
XRCC6	-140.0
DTX4	-6299.0

---

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

	640
set	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
setSize	14
pANOVA	0.00454
s.dist	0.438
p.adjustANOVA	0.0322

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LIG1	5975
PCNA	5717
POLD4	5634
EXO1	5078
RPA2	4286
POLD2	3892
POLD3	3547
RPA3	3116
POLD1	2030
PMS2	1726
MSH2	1714
RPA1	565
MLH1	118
MSH6	-1534

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LIG1	5975
PCNA	5717
POLD4	5634
EXO1	5078
RPA2	4286
POLD2	3892
POLD3	3547
RPA3	3116
POLD1	2030
PMS2	1726
MSH2	1714
RPA1	565
MLH1	118
MSH6	-1534

---

FRS-mediated FGFR4 signaling

FRS-mediated FGFR4 signaling

	366
set	FRS-mediated FGFR4 signaling
setSize	13
pANOVA	0.00628
s.dist	-0.438
p.adjustANOVA	0.0411

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	-6071
FGF2	-5365
PTPN11	-5252
FGF1	-4776
FGF9	-4745
FRS2	-4514
SOS1	-4192
FGF18	-3601
FRS3	-3072
FGF16	-167
HRAS	314
KRAS	1682
NRAS	4196

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	-6071
FGF2	-5365
PTPN11	-5252
FGF1	-4776
FGF9	-4745
FRS2	-4514
SOS1	-4192
FGF18	-3601
FRS3	-3072
FGF16	-167
HRAS	314
KRAS	1682
NRAS	4196

---

G0 and Early G1

G0 and Early G1

	403
set	G0 and Early G1
setSize	25
pANOVA	0.000164
s.dist	0.435
p.adjustANOVA	0.00289

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCNA2	6408
LIN52	5794
TFDP2	5729
PCNA	5717
RBL1	5524
MAX	5381
CDK2	5364
MYBL2	5356
TOP2A	5197
LIN9	4638
E2F1	4577
CDK1	4567
CCNE1	3709
CDC6	3683
RBL2	3404
RBBP4	3130
CCNE2	3040
CDC25A	2955
LIN54	2297
MYC	2028

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCNA2	6408.0
LIN52	5794.0
TFDP2	5729.0
PCNA	5717.0
RBL1	5524.0
MAX	5381.0
CDK2	5364.0
MYBL2	5356.0
TOP2A	5197.0
LIN9	4638.0
E2F1	4577.0
CDK1	4567.0
CCNE1	3709.0
CDC6	3683.0
RBL2	3404.0
RBBP4	3130.0
CCNE2	3040.0
CDC25A	2955.0
LIN54	2297.0
MYC	2028.0
E2F5	-99.0
LIN37	-1656.0
E2F4	-3260.0
DYRK1A	-4345.0
TFDP1	-4870.5

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	421
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	75
pANOVA	9.63e-11
s.dist	0.432
p.adjustANOVA	9.18e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
EIF4A1	4970
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL11	6051.0
RPS15A	5982.0
RPL15	5940.0
RPS9	5715.0
RPLP2	5666.0
RPS27L	5648.0
RPL22L1	5575.0
RPS24	5481.0
RPL3	5445.0
RPL18A	5312.0
RPS8	5269.0
RPS4X	5238.0
RPL10	5221.0
RPL36A	5189.0
RPS16	5049.0
EIF4A1	4970.0
RPS18	4951.0
RPL30	4938.0
RPL23	4933.0
RPS27	4820.0
RPL38	4766.0
RPS20	4641.0
RPS19	4592.0
RPL4	4575.0
EIF5	4495.0
RPL32	4479.0
RPS12	4369.0
EIF3E	4262.0
RPS5	4221.0
RPS13	4118.0
FAU	4042.0
RPL19	4026.0
RPL37	4012.0
RPS11	3869.0
RPS3	3755.0
EIF2S1	3690.0
RPS27A	3675.0
EIF4H	3626.0
EIF3H	3543.0
RPL34	3338.0
RPL31	3304.0
RPS15	3273.0
RPL35A	3238.0
RPL7	3132.0
RPL37A	3126.0
RPS21	3110.0
RPL8	3017.0
RPL18	2994.0
RPS23	2821.0
EIF2S2	2646.0
RPS6	2632.0
EIF3M	2518.0
RPL5	2246.0
RPL22	2123.0
RPL14	2066.0
RPS14	1909.0
EIF5B	1853.0
RPS26	1816.0
RPL26	1693.0
RPL28	811.0
EIF4B	693.0
EIF3F	563.0
EIF3G	273.0
RPS29	193.0
EIF3B	-667.0
EIF3I	-757.0
EIF3A	-930.0
EIF4A2	-1268.0
EIF3C	-1448.5
RPL3L	-1683.0
EIF3D	-2078.0
EIF3L	-2101.0
EIF3K	-2420.0
EIF4E	-3006.0
EIF4G1	-4661.0

---

Antimicrobial peptides

Antimicrobial peptides

	77
set	Antimicrobial peptides
setSize	13
pANOVA	0.00707
s.dist	0.432
p.adjustANOVA	0.044

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCR2	6618
LYZ	6594
TLR2	6054
TLR1	5971
ATP7A	5311
CD4	5297
SLC11A1	4870
LCN2	4171
ART1	2908
PDZD11	1394
ATOX1	-841
DEFB136	-4639
CLU	-5390

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCR2	6618
LYZ	6594
TLR2	6054
TLR1	5971
ATP7A	5311
CD4	5297
SLC11A1	4870
LCN2	4171
ART1	2908
PDZD11	1394
ATOX1	-841
DEFB136	-4639
CLU	-5390

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	569
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	73
pANOVA	1.88e-10
s.dist	0.431
p.adjustANOVA	1.48e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL11	6051
RPS15A	5982
RPL15	5940
RPS9	5715
RPLP2	5666
RPS27L	5648
RPL22L1	5575
RPS24	5481
RPL3	5445
RPL18A	5312
RPS8	5269
RPS4X	5238
RPL10	5221
RPL36A	5189
RPS16	5049
EIF4A1	4970
RPS18	4951
RPL30	4938
RPL23	4933
RPS27	4820

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL11	6051.0
RPS15A	5982.0
RPL15	5940.0
RPS9	5715.0
RPLP2	5666.0
RPS27L	5648.0
RPL22L1	5575.0
RPS24	5481.0
RPL3	5445.0
RPL18A	5312.0
RPS8	5269.0
RPS4X	5238.0
RPL10	5221.0
RPL36A	5189.0
RPS16	5049.0
EIF4A1	4970.0
RPS18	4951.0
RPL30	4938.0
RPL23	4933.0
RPS27	4820.0
RPL38	4766.0
RPS20	4641.0
RPS19	4592.0
RPL4	4575.0
RPL32	4479.0
RPS12	4369.0
EIF3E	4262.0
RPS5	4221.0
RPS13	4118.0
FAU	4042.0
RPL19	4026.0
RPL37	4012.0
RPS11	3869.0
RPS3	3755.0
EIF2S1	3690.0
RPS27A	3675.0
EIF4H	3626.0
EIF3H	3543.0
RPL34	3338.0
RPL31	3304.0
RPS15	3273.0
RPL35A	3238.0
RPL7	3132.0
RPL37A	3126.0
RPS21	3110.0
RPL8	3017.0
RPL18	2994.0
RPS23	2821.0
EIF2S2	2646.0
RPS6	2632.0
EIF3M	2518.0
RPL5	2246.0
RPL22	2123.0
RPL14	2066.0
RPS14	1909.0
RPS26	1816.0
RPL26	1693.0
RPL28	811.0
EIF4B	693.0
EIF3F	563.0
EIF3G	273.0
RPS29	193.0
EIF3B	-667.0
EIF3I	-757.0
EIF3A	-930.0
EIF4A2	-1268.0
EIF3C	-1448.5
RPL3L	-1683.0
EIF3D	-2078.0
EIF3L	-2101.0
EIF3K	-2420.0
EIF4E	-3006.0
EIF4G1	-4661.0

---

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

	639
set	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
setSize	14
pANOVA	0.00544
s.dist	0.429
p.adjustANOVA	0.037

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LIG1	5975
PCNA	5717
POLD4	5634
EXO1	5078
RPA2	4286
POLD2	3892
POLD3	3547
RPA3	3116
POLD1	2030
PMS2	1726
MSH2	1714
RPA1	565
MLH1	118
MSH3	-2352

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LIG1	5975
PCNA	5717
POLD4	5634
EXO1	5078
RPA2	4286
POLD2	3892
POLD3	3547
RPA3	3116
POLD1	2030
PMS2	1726
MSH2	1714
RPA1	565
MLH1	118
MSH3	-2352

---

Condensation of Prophase Chromosomes

Condensation of Prophase Chromosomes

	203
set	Condensation of Prophase Chromosomes
setSize	13
pANOVA	0.00743
s.dist	0.429
p.adjustANOVA	0.0447

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMC2	6323
SET	6264
CCNB1	5801
SMC4	5778
NCAPG2	5768
NCAPD3	5036
CDK1	4567
PLK1	3607
H2AFX	2613
NCAPH2	-853
MCPH1	-2032
RB1	-2219
PHF8	-2562

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMC2	6323
SET	6264
CCNB1	5801
SMC4	5778
NCAPG2	5768
NCAPD3	5036
CDK1	4567
PLK1	3607
H2AFX	2613
NCAPH2	-853
MCPH1	-2032
RB1	-2219
PHF8	-2562

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] fgsea_1.14.0                gplots_3.0.3               
##  [9] DESeq2_1.28.1               SummarizedExperiment_1.18.1
## [11] DelayedArray_0.14.0         matrixStats_0.56.0         
## [13] Biobase_2.48.0              GenomicRanges_1.40.0       
## [15] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [17] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [19] reshape2_1.4.4              forcats_0.5.0              
## [21] stringr_1.4.0               dplyr_1.0.0                
## [23] purrr_0.3.4                 readr_1.3.1                
## [25] tidyr_1.1.0                 tibble_3.0.1               
## [27] ggplot2_3.3.2               tidyverse_1.3.0            
## [29] locfit_1.5-9.4              statmod_1.4.34             
## [31] plyr_1.8.6                 
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] MASS_7.3-51.6          scales_1.1.1           hms_0.5.3             
## [49] promises_1.1.1         RColorBrewer_1.1-2     yaml_2.2.1            
## [52] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
## [55] stringi_1.4.6          RSQLite_2.2.0          highr_0.8             
## [58] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
## [61] BiocParallel_1.22.0    rlang_0.4.6            pkgconfig_2.0.3       
## [64] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
## [67] htmlwidgets_1.5.1      bit_1.1-15.2           tidyselect_1.1.0      
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          grid_4.0.2             readxl_1.3.1          
## [85] data.table_1.12.8      blob_1.2.1             reprex_0.3.0          
## [88] digest_0.6.25          pbmcapply_1.5.0        xtable_1.8-4          
## [91] httpuv_1.5.4           munsell_0.5.0

END of report