date generated: 2020-07-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## A2M      0.6662719
## A3GALT2 -0.7307640
## A4GALT   1.5792346
## AAAS     1.2886140
## AACS    -1.1333351
## AAED1    0.9638579

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 13952
duplicated_genes_present 0
num_profile_genes_in_sets 7902
num_profile_genes_not_in_sets 6050

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1047
num_genesets_included 1353

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set setSize pANOVA s.dist p.adjustANOVA
Classical antibody-mediated complement activation 10 8.95e-07 0.897 7.94e-06
Unwinding of DNA 12 2.19e-07 0.864 2.12e-06
DNA strand elongation 32 8.38e-15 0.792 3.99e-13
Leading Strand Synthesis 14 3.28e-07 0.788 3.04e-06
Polymerase switching 14 3.28e-07 0.788 3.04e-06
Lagging Strand Synthesis 20 6.91e-09 0.748 8.28e-08
Processive synthesis on the lagging strand 15 1.44e-06 0.719 1.22e-05
Removal of the Flap Intermediate 14 3.42e-06 0.717 2.67e-05
GP1b-IX-V activation signalling 10 8.82e-05 -0.716 5.30e-04
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.50e-06 0.696 4.86e-05
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 6.44e-05 0.666 4.01e-04
PCNA-Dependent Long Patch Base Excision Repair 21 1.27e-07 0.666 1.25e-06
Mucopolysaccharidoses 11 1.85e-04 0.651 1.03e-03
G1/S-Specific Transcription 27 8.57e-09 0.640 1.01e-07
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.47e-05 0.630 2.88e-04
cGMP effects 13 1.03e-04 -0.622 6.14e-04
Activation of the pre-replicative complex 32 1.53e-09 0.617 2.03e-08
Assembly of the pre-replicative complex 62 2.22e-16 0.603 1.88e-14
Digestion 13 1.76e-04 -0.601 9.87e-04
Mismatch Repair 15 6.24e-05 0.597 3.93e-04
DNA Replication Pre-Initiation 78 8.06e-20 0.597 7.79e-18
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 4.29e-07 0.596 3.87e-06
E2F mediated regulation of DNA replication 21 2.57e-06 0.593 2.07e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 46 5.17e-12 0.588 1.13e-10
p53-Independent DNA Damage Response 46 5.17e-12 0.588 1.13e-10
p53-Independent G1/S DNA damage checkpoint 46 5.17e-12 0.588 1.13e-10
Polo-like kinase mediated events 16 4.78e-05 0.587 3.05e-04
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.14e-06 0.586 9.78e-06
CDT1 association with the CDC6:ORC:origin complex 53 3.93e-13 0.576 1.18e-11
Orc1 removal from chromatin 64 1.82e-15 0.575 1.02e-13
Regulation of ornithine decarboxylase (ODC) 46 1.71e-11 0.573 3.35e-10
Termination of translesion DNA synthesis 29 1.41e-07 0.565 1.38e-06
SCF-beta-TrCP mediated degradation of Emi1 49 8.21e-12 0.564 1.68e-10
Synthesis of DNA 113 5.01e-25 0.562 8.48e-23
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 1.63e-04 0.562 9.20e-04
Cross-presentation of soluble exogenous antigens (endosomes) 46 4.29e-11 0.562 7.35e-10
Ubiquitin-dependent degradation of Cyclin D 46 4.54e-11 0.561 7.67e-10
DNA Replication 120 3.58e-26 0.559 9.68e-24
Regulation of activated PAK-2p34 by proteasome mediated degradation 44 1.39e-10 0.559 2.21e-09
Peptide chain elongation 56 4.98e-13 0.558 1.41e-11
Metabolism of polyamines 52 4.60e-12 0.554 1.11e-10
Deposition of new CENPA-containing nucleosomes at the centromere 25 1.63e-06 0.554 1.34e-05
Nucleosome assembly 25 1.63e-06 0.554 1.34e-05
Formation of a pool of free 40S subunits 66 8.09e-15 0.553 3.99e-13
Translesion Synthesis by POLH 16 1.34e-04 0.551 7.84e-04
Vif-mediated degradation of APOBEC3G 45 1.54e-10 0.551 2.42e-09
Autodegradation of the E3 ubiquitin ligase COP1 46 1.27e-10 0.548 2.05e-09
AUF1 (hnRNP D0) binds and destabilizes mRNA 48 5.84e-11 0.546 9.75e-10
G1/S Transition 121 3.86e-25 0.545 7.46e-23
The role of GTSE1 in G2/M progression after G2 checkpoint 54 5.05e-12 0.543 1.13e-10


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Classical antibody-mediated complement activation 10 8.95e-07 0.897000 7.94e-06
Unwinding of DNA 12 2.19e-07 0.864000 2.12e-06
DNA strand elongation 32 8.38e-15 0.792000 3.99e-13
Leading Strand Synthesis 14 3.28e-07 0.788000 3.04e-06
Polymerase switching 14 3.28e-07 0.788000 3.04e-06
Lagging Strand Synthesis 20 6.91e-09 0.748000 8.28e-08
Processive synthesis on the lagging strand 15 1.44e-06 0.719000 1.22e-05
Removal of the Flap Intermediate 14 3.42e-06 0.717000 2.67e-05
GP1b-IX-V activation signalling 10 8.82e-05 -0.716000 5.30e-04
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.50e-06 0.696000 4.86e-05
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 6.44e-05 0.666000 4.01e-04
PCNA-Dependent Long Patch Base Excision Repair 21 1.27e-07 0.666000 1.25e-06
Mucopolysaccharidoses 11 1.85e-04 0.651000 1.03e-03
G1/S-Specific Transcription 27 8.57e-09 0.640000 1.01e-07
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.47e-05 0.630000 2.88e-04
cGMP effects 13 1.03e-04 -0.622000 6.14e-04
Activation of the pre-replicative complex 32 1.53e-09 0.617000 2.03e-08
Assembly of the pre-replicative complex 62 2.22e-16 0.603000 1.88e-14
Digestion 13 1.76e-04 -0.601000 9.87e-04
Mismatch Repair 15 6.24e-05 0.597000 3.93e-04
DNA Replication Pre-Initiation 78 8.06e-20 0.597000 7.79e-18
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 4.29e-07 0.596000 3.87e-06
E2F mediated regulation of DNA replication 21 2.57e-06 0.593000 2.07e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 46 5.17e-12 0.588000 1.13e-10
p53-Independent DNA Damage Response 46 5.17e-12 0.588000 1.13e-10
p53-Independent G1/S DNA damage checkpoint 46 5.17e-12 0.588000 1.13e-10
Polo-like kinase mediated events 16 4.78e-05 0.587000 3.05e-04
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.14e-06 0.586000 9.78e-06
CDT1 association with the CDC6:ORC:origin complex 53 3.93e-13 0.576000 1.18e-11
Orc1 removal from chromatin 64 1.82e-15 0.575000 1.02e-13
Regulation of ornithine decarboxylase (ODC) 46 1.71e-11 0.573000 3.35e-10
Termination of translesion DNA synthesis 29 1.41e-07 0.565000 1.38e-06
SCF-beta-TrCP mediated degradation of Emi1 49 8.21e-12 0.564000 1.68e-10
Synthesis of DNA 113 5.01e-25 0.562000 8.48e-23
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 1.63e-04 0.562000 9.20e-04
Cross-presentation of soluble exogenous antigens (endosomes) 46 4.29e-11 0.562000 7.35e-10
Ubiquitin-dependent degradation of Cyclin D 46 4.54e-11 0.561000 7.67e-10
DNA Replication 120 3.58e-26 0.559000 9.68e-24
Regulation of activated PAK-2p34 by proteasome mediated degradation 44 1.39e-10 0.559000 2.21e-09
Peptide chain elongation 56 4.98e-13 0.558000 1.41e-11
Metabolism of polyamines 52 4.60e-12 0.554000 1.11e-10
Deposition of new CENPA-containing nucleosomes at the centromere 25 1.63e-06 0.554000 1.34e-05
Nucleosome assembly 25 1.63e-06 0.554000 1.34e-05
Formation of a pool of free 40S subunits 66 8.09e-15 0.553000 3.99e-13
Translesion Synthesis by POLH 16 1.34e-04 0.551000 7.84e-04
Vif-mediated degradation of APOBEC3G 45 1.54e-10 0.551000 2.42e-09
Autodegradation of the E3 ubiquitin ligase COP1 46 1.27e-10 0.548000 2.05e-09
AUF1 (hnRNP D0) binds and destabilizes mRNA 48 5.84e-11 0.546000 9.75e-10
G1/S Transition 121 3.86e-25 0.545000 7.46e-23
The role of GTSE1 in G2/M progression after G2 checkpoint 54 5.05e-12 0.543000 1.13e-10
Phase 2 - plateau phase 20 2.73e-05 -0.542000 1.85e-04
Telomere C-strand (Lagging Strand) Synthesis 33 8.61e-08 0.538000 8.69e-07
SCF(Skp2)-mediated degradation of p27/p21 53 1.46e-11 0.536000 2.91e-10
Eukaryotic Translation Elongation 60 7.99e-13 0.534000 2.16e-11
Eukaryotic Translation Termination 59 1.25e-12 0.534000 3.26e-11
Viral mRNA Translation 56 4.95e-12 0.534000 1.13e-10
Recognition of DNA damage by PCNA-containing replication complex 28 1.05e-06 0.533000 9.15e-06
SRP-dependent cotranslational protein targeting to membrane 77 8.87e-16 0.530000 6.29e-14
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 48 2.24e-10 0.529000 3.37e-09
Transcription of E2F targets under negative control by DREAM complex 18 1.12e-04 0.526000 6.62e-04
Striated Muscle Contraction 31 4.04e-07 -0.526000 3.69e-06
Polymerase switching on the C-strand of the telomere 25 5.45e-06 0.525000 4.10e-05
Vpu mediated degradation of CD4 46 7.17e-10 0.525000 9.89e-09
Formation of the ternary complex, and subsequently, the 43S complex 39 1.42e-08 0.525000 1.60e-07
Translesion synthesis by POLI 15 4.37e-04 0.524000 2.25e-03
Presynaptic depolarization and calcium channel opening 12 1.72e-03 -0.523000 7.75e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 49 2.50e-10 0.522000 3.72e-09
Acetylcholine Neurotransmitter Release Cycle 10 4.44e-03 -0.520000 1.74e-02
Hh mutants abrogate ligand secretion 50 2.17e-10 0.519000 3.31e-09
Translocation of ZAP-70 to Immunological synapse 12 1.88e-03 -0.518000 8.37e-03
Selenocysteine synthesis 59 5.86e-12 0.518000 1.24e-10
L13a-mediated translational silencing of Ceruloplasmin expression 74 1.37e-14 0.518000 5.77e-13
Defective CFTR causes cystic fibrosis 53 7.82e-11 0.516000 1.29e-09
Negative regulation of NOTCH4 signaling 48 6.05e-10 0.516000 8.52e-09
tRNA processing in the mitochondrion 16 3.67e-04 -0.514000 1.93e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 61 3.74e-12 0.514000 9.19e-11
Regulation of Apoptosis 47 1.08e-09 0.514000 1.45e-08
Cap-dependent Translation Initiation 82 9.76e-16 0.513000 6.29e-14
Eukaryotic Translation Initiation 82 9.76e-16 0.513000 6.29e-14
Activation of ATR in response to replication stress 37 7.19e-08 0.512000 7.43e-07
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 1.42e-03 0.511000 6.58e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 70 1.48e-13 0.511000 4.87e-12
Autodegradation of Cdh1 by Cdh1:APC/C 58 1.78e-11 0.510000 3.40e-10
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 67 5.26e-13 0.510000 1.45e-11
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 66 8.17e-13 0.509000 2.17e-11
ATF6 (ATF6-alpha) activates chaperone genes 10 5.40e-03 0.508000 2.05e-02
Laminin interactions 23 2.55e-05 -0.507000 1.75e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 68 5.01e-13 0.507000 1.41e-11
APC/C:Cdc20 mediated degradation of mitotic proteins 69 3.50e-13 0.506000 1.08e-11
Hyaluronan uptake and degradation 12 2.39e-03 0.506000 1.03e-02
Switching of origins to a post-replicative state 84 1.17e-15 0.505000 7.22e-14
Mitochondrial translation elongation 85 8.39e-16 0.505000 6.29e-14
Purine catabolism 16 4.72e-04 0.505000 2.40e-03
Digestion and absorption 14 1.09e-03 -0.504000 5.17e-03
VLDLR internalisation and degradation 11 3.91e-03 0.502000 1.58e-02
G0 and Early G1 25 1.42e-05 0.502000 1.00e-04
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 1.44e-05 0.501000 1.02e-04
Mitochondrial translation termination 85 1.70e-15 0.500000 1.00e-13
GTP hydrolysis and joining of the 60S ribosomal subunit 76 5.75e-14 0.499000 2.10e-12
Trafficking and processing of endosomal TLR 11 4.22e-03 0.498000 1.67e-02
Regulation of APC/C activators between G1/S and early anaphase 74 1.32e-13 0.498000 4.58e-12
APC/C-mediated degradation of cell cycle proteins 81 1.00e-14 0.497000 4.37e-13
Regulation of mitotic cell cycle 81 1.00e-14 0.497000 4.37e-13
Translesion synthesis by REV1 14 1.33e-03 0.495000 6.20e-03
CDK-mediated phosphorylation and removal of Cdc6 66 5.71e-12 0.490000 1.23e-10
Mitotic G1 phase and G1/S transition 138 3.83e-23 0.489000 4.32e-21
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 46 1.00e-08 0.488000 1.16e-07
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.41e-04 0.488000 1.82e-03
APC/C:Cdc20 mediated degradation of Securin 62 3.68e-11 0.486000 6.38e-10
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 1.65e-03 -0.486000 7.49e-03
Diseases of hemostasis 14 1.65e-03 -0.486000 7.49e-03
Translation initiation complex formation 45 1.96e-08 0.484000 2.19e-07
Generation of second messenger molecules 27 1.36e-05 -0.484000 9.70e-05
Pentose phosphate pathway 13 2.57e-03 0.483000 1.08e-02
Cyclin A:Cdk2-associated events at S phase entry 78 1.75e-13 0.482000 5.52e-12
Hedgehog ligand biogenesis 54 8.65e-10 0.482000 1.17e-08
Mitochondrial translation initiation 85 1.54e-14 0.482000 6.32e-13
Norepinephrine Neurotransmitter Release Cycle 12 3.88e-03 -0.481000 1.58e-02
Condensation of Prometaphase Chromosomes 11 5.70e-03 0.481000 2.14e-02
Cyclin E associated events during G1/S transition 76 4.03e-13 0.481000 1.19e-11
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 8.98e-07 0.480000 7.94e-06
Degradation of GLI2 by the proteasome 52 2.51e-09 0.478000 3.26e-08
Stabilization of p53 50 5.14e-09 0.478000 6.32e-08
Heme biosynthesis 13 2.87e-03 0.478000 1.20e-02
Degradation of GLI1 by the proteasome 53 1.91e-09 0.477000 2.50e-08
Serotonin Neurotransmitter Release Cycle 12 4.24e-03 -0.477000 1.67e-02
Cholesterol biosynthesis 23 7.88e-05 -0.476000 4.84e-04
S Phase 154 2.61e-24 0.475000 3.93e-22
Condensation of Prophase Chromosomes 13 3.03e-03 0.475000 1.26e-02
Degradation of DVL 51 4.79e-09 0.474000 6.06e-08
HDR through Homologous Recombination (HRR) 63 9.79e-11 0.471000 1.60e-09
CDC6 association with the ORC:origin complex 11 7.00e-03 0.470000 2.54e-02
Apoptotic factor-mediated response 13 3.39e-03 0.469000 1.39e-02
Ribosomal scanning and start codon recognition 46 4.30e-08 0.467000 4.62e-07
GLI3 is processed to GLI3R by the proteasome 52 5.86e-09 0.467000 7.08e-08
Resolution of D-loop Structures through Holliday Junction Intermediates 31 7.06e-06 0.466000 5.22e-05
Resolution of D-Loop Structures 32 5.06e-06 0.466000 3.85e-05
Initiation of Nuclear Envelope (NE) Reformation 19 4.39e-04 0.466000 2.25e-03
Influenza Viral RNA Transcription and Replication 97 2.24e-15 0.466000 1.21e-13
FCGR activation 17 8.88e-04 0.466000 4.31e-03
Mitochondrial translation 91 1.66e-14 0.466000 6.51e-13
G2/M Checkpoints 126 2.85e-19 0.463000 2.57e-17
Homologous DNA Pairing and Strand Exchange 41 2.97e-07 0.463000 2.79e-06
Chromosome Maintenance 86 1.36e-13 0.462000 4.59e-12
Translesion synthesis by POLK 15 1.98e-03 0.461000 8.72e-03
NIK-->noncanonical NF-kB signaling 52 9.15e-09 0.461000 1.07e-07
Translation 231 2.12e-33 0.460000 9.58e-31
ABC transporter disorders 62 3.81e-10 0.460000 5.42e-09
Selenoamino acid metabolism 71 2.79e-11 0.457000 4.97e-10
Retrograde neurotrophin signalling 13 4.42e-03 0.456000 1.74e-02
Dectin-1 mediated noncanonical NF-kB signaling 54 8.12e-09 0.454000 9.63e-08
Resolution of Abasic Sites (AP sites) 37 1.86e-06 0.453000 1.52e-05
Response of EIF2AK4 (GCN2) to amino acid deficiency 66 2.18e-10 0.452000 3.31e-09
Cyclin A/B1/B2 associated events during G2/M transition 23 1.87e-04 0.450000 1.04e-03
Extension of Telomeres 49 5.71e-08 0.448000 6.04e-07
Presynaptic phase of homologous DNA pairing and strand exchange 38 1.93e-06 0.446000 1.56e-05
Initial triggering of complement 21 4.03e-04 0.446000 2.10e-03
DNA Damage Bypass 44 3.98e-07 0.442000 3.66e-06
Phosphorylation of CD3 and TCR zeta chains 15 3.06e-03 -0.442000 1.26e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 65 8.45e-10 0.440000 1.15e-08
Regulation of RUNX3 expression and activity 48 1.75e-07 0.436000 1.70e-06
Telomere Maintenance 63 2.71e-09 0.433000 3.49e-08
Degradation of cysteine and homocysteine 12 9.39e-03 0.433000 3.18e-02
HDMs demethylate histones 21 6.10e-04 -0.432000 3.03e-03
Influenza Infection 113 2.93e-15 0.430000 1.52e-13
ER-Phagosome pathway 69 7.15e-10 0.429000 9.89e-09
Degradation of AXIN 49 2.25e-07 0.428000 2.16e-06
Mitochondrial iron-sulfur cluster biogenesis 12 1.07e-02 0.426000 3.50e-02
G1/S DNA Damage Checkpoints 60 1.33e-08 0.424000 1.52e-07
Separation of Sister Chromatids 158 4.13e-20 0.424000 4.30e-18
Regulation of expression of SLITs and ROBOs 126 3.07e-16 0.422000 2.44e-14
Nitric oxide stimulates guanylate cyclase 19 1.46e-03 -0.422000 6.72e-03
ATF6 (ATF6-alpha) activates chaperones 12 1.17e-02 0.420000 3.76e-02
p53-Dependent G1 DNA Damage Response 58 3.36e-08 0.419000 3.67e-07
p53-Dependent G1/S DNA damage checkpoint 58 3.36e-08 0.419000 3.67e-07
Asymmetric localization of PCP proteins 58 3.54e-08 0.419000 3.83e-07
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 87 2.61e-11 0.414000 4.76e-10
Amplification of signal from the kinetochores 87 2.61e-11 0.414000 4.76e-10
Postmitotic nuclear pore complex (NPC) reformation 25 3.49e-04 0.413000 1.85e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 57 7.01e-08 0.413000 7.30e-07
PD-1 signaling 16 4.48e-03 -0.410000 1.75e-02
Homology Directed Repair 97 2.99e-12 0.410000 7.50e-11
Processive synthesis on the C-strand of the telomere 19 2.05e-03 0.409000 8.99e-03
Platelet Adhesion to exposed collagen 13 1.11e-02 -0.407000 3.59e-02
Cell Cycle Checkpoints 241 2.14e-27 0.406000 7.25e-25
Metabolism of porphyrins 23 7.63e-04 0.406000 3.77e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 91 2.64e-11 0.404000 4.76e-10
Mitotic Metaphase and Anaphase 211 5.42e-24 0.404000 7.34e-22
Mitotic Anaphase 210 1.14e-23 0.402000 1.40e-21
Rev-mediated nuclear export of HIV RNA 30 1.63e-04 0.398000 9.20e-04
rRNA processing in the mitochondrion 17 4.69e-03 -0.396000 1.81e-02
Interactions of Rev with host cellular proteins 31 1.39e-04 0.395000 8.13e-04
Activation of gene expression by SREBF (SREBP) 41 1.33e-05 -0.393000 9.60e-05
GABA synthesis, release, reuptake and degradation 15 8.68e-03 -0.391000 3.01e-02
Resolution of Sister Chromatid Cohesion 99 1.77e-11 0.391000 3.40e-10
Long-term potentiation 18 4.16e-03 -0.390000 1.66e-02
SUMOylation of DNA replication proteins 40 1.97e-05 0.390000 1.37e-04
TP53 Regulates Transcription of Death Receptors and Ligands 12 1.98e-02 -0.388000 5.74e-02
Viral Messenger RNA Synthesis 38 3.70e-05 0.387000 2.43e-04
Nucleobase biosynthesis 15 9.71e-03 0.386000 3.28e-02
Nuclear import of Rev protein 28 4.22e-04 0.385000 2.18e-03
Sulfur amino acid metabolism 22 1.83e-03 0.384000 8.15e-03
Creation of C4 and C2 activators 14 1.29e-02 0.384000 4.01e-02
Mitotic Spindle Checkpoint 104 1.45e-11 0.383000 2.91e-10
EML4 and NUDC in mitotic spindle formation 91 2.65e-10 0.383000 3.85e-09
Dopamine Neurotransmitter Release Cycle 15 1.04e-02 -0.382000 3.44e-02
Diseases of carbohydrate metabolism 28 4.84e-04 0.381000 2.45e-03
MASTL Facilitates Mitotic Progression 10 3.71e-02 0.381000 9.48e-02
Base Excision Repair 45 1.02e-05 0.380000 7.44e-05
Regulation of PTEN stability and activity 62 2.34e-07 0.380000 2.23e-06
CLEC7A (Dectin-1) induces NFAT activation 10 3.77e-02 -0.380000 9.60e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 81 5.05e-09 0.376000 6.27e-08
Nonsense-Mediated Decay (NMD) 81 5.05e-09 0.376000 6.27e-08
Glutamate and glutamine metabolism 11 3.13e-02 0.375000 8.25e-02
Cytochrome c-mediated apoptotic response 10 4.01e-02 0.375000 1.01e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 22 2.40e-03 0.374000 1.03e-02
Regulation of PTEN mRNA translation 11 3.18e-02 -0.374000 8.34e-02
HDR through Single Strand Annealing (SSA) 36 1.11e-04 0.372000 6.62e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 4.20e-02 -0.371000 1.05e-01
Heme degradation 11 3.34e-02 0.370000 8.70e-02
Detoxification of Reactive Oxygen Species 30 4.52e-04 0.370000 2.31e-03
Removal of the Flap Intermediate from the C-strand 17 8.29e-03 0.370000 2.91e-02
Antigen processing-Cross presentation 84 5.29e-09 0.369000 6.45e-08
Phase 0 - rapid depolarisation 33 2.61e-04 -0.367000 1.41e-03
Dual Incision in GG-NER 39 7.47e-05 0.367000 4.62e-04
CaMK IV-mediated phosphorylation of CREB 10 4.51e-02 -0.366000 1.10e-01
Diseases associated with N-glycosylation of proteins 16 1.13e-02 0.366000 3.66e-02
Plasma lipoprotein clearance 28 8.75e-04 0.363000 4.27e-03
Unblocking of NMDA receptors, glutamate binding and activation 16 1.20e-02 -0.363000 3.83e-02
Regulation of necroptotic cell death 13 2.40e-02 -0.362000 6.72e-02
Metabolism of folate and pterines 15 1.54e-02 0.361000 4.66e-02
Host Interactions of HIV factors 114 2.93e-11 0.361000 5.14e-10
Cell Cycle, Mitotic 466 9.51e-40 0.358000 6.43e-37
Effects of PIP2 hydrolysis 24 2.50e-03 -0.357000 1.06e-02
Intrinsic Pathway of Fibrin Clot Formation 17 1.12e-02 -0.356000 3.61e-02
Cellular response to hypoxia 65 7.63e-07 0.355000 6.84e-06
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 3.35e-03 -0.353000 1.37e-02
Mitochondrial protein import 59 2.81e-06 0.353000 2.22e-05
Vpr-mediated nuclear import of PICs 29 1.01e-03 0.353000 4.85e-03
Interferon alpha/beta signaling 45 4.37e-05 0.352000 2.83e-04
NEP/NS2 Interacts with the Cellular Export Machinery 27 1.55e-03 0.352000 7.09e-03
HCMV Late Events 47 3.02e-05 0.352000 2.04e-04
Nuclear Envelope (NE) Reassembly 65 1.10e-06 0.350000 9.57e-06
Ras activation upon Ca2+ influx through NMDA receptor 18 1.04e-02 -0.349000 3.44e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 25 2.53e-03 0.349000 1.07e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 25 2.53e-03 0.349000 1.07e-02
LDL clearance 16 1.59e-02 0.348000 4.77e-02
ABC-family proteins mediated transport 86 2.51e-08 0.348000 2.78e-07
UCH proteinases 78 1.14e-07 0.348000 1.14e-06
Pausing and recovery of Tat-mediated HIV elongation 26 2.22e-03 0.347000 9.58e-03
Tat-mediated HIV elongation arrest and recovery 26 2.22e-03 0.347000 9.58e-03
Metabolism of non-coding RNA 48 3.48e-05 0.346000 2.31e-04
snRNP Assembly 48 3.48e-05 0.346000 2.31e-04
Insulin processing 22 5.20e-03 -0.344000 1.99e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 75 2.71e-07 0.344000 2.56e-06
Common Pathway of Fibrin Clot Formation 15 2.13e-02 -0.343000 6.06e-02
Platelet Aggregation (Plug Formation) 32 8.11e-04 -0.342000 3.99e-03
MET activates PTK2 signaling 18 1.20e-02 -0.342000 3.83e-02
VEGFR2 mediated cell proliferation 19 1.01e-02 -0.341000 3.39e-02
Glycogen breakdown (glycogenolysis) 14 2.78e-02 -0.340000 7.53e-02
Mitotic G2-G2/M phases 176 8.55e-15 0.339000 3.99e-13
G2/M Transition 174 1.68e-14 0.338000 6.51e-13
PCP/CE pathway 85 7.62e-08 0.338000 7.81e-07
Signaling by NTRK3 (TRKC) 17 1.60e-02 -0.337000 4.78e-02
APC-Cdc20 mediated degradation of Nek2A 24 4.23e-03 0.337000 1.67e-02
M Phase 327 1.59e-25 0.337000 3.59e-23
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.00e-02 0.335000 7.97e-02
Signaling by FGFR2 IIIa TM 18 1.40e-02 0.335000 4.30e-02
Regulation of beta-cell development 26 3.19e-03 -0.334000 1.31e-02
Nuclear Pore Complex (NPC) Disassembly 31 1.29e-03 0.334000 6.04e-03
Fanconi Anemia Pathway 32 1.08e-03 0.334000 5.17e-03
Cell Cycle 586 5.75e-43 0.334000 7.78e-40
Activation of NF-kappaB in B cells 61 6.83e-06 0.333000 5.08e-05
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 22 6.86e-03 -0.333000 2.52e-02
DNA Double-Strand Break Repair 124 1.58e-10 0.333000 2.45e-09
Regulation of RUNX2 expression and activity 65 3.54e-06 0.333000 2.76e-05
Synthesis of PIPs at the early endosome membrane 16 2.13e-02 -0.333000 6.06e-02
LGI-ADAM interactions 14 3.13e-02 -0.332000 8.25e-02
Inactivation of APC/C via direct inhibition of the APC/C complex 21 8.58e-03 0.331000 2.99e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 8.58e-03 0.331000 2.99e-02
Interactions of Vpr with host cellular proteins 31 1.43e-03 0.331000 6.59e-03
Gap-filling DNA repair synthesis and ligation in TC-NER 61 8.05e-06 0.331000 5.92e-05
Regulation of RAS by GAPs 61 8.17e-06 0.330000 5.98e-05
Processing of DNA double-strand break ends 58 1.46e-05 0.329000 1.02e-04
Formation of Fibrin Clot (Clotting Cascade) 28 2.60e-03 -0.329000 1.09e-02
Glutamate Neurotransmitter Release Cycle 18 1.60e-02 -0.328000 4.78e-02
Processing of SMDT1 15 2.90e-02 0.326000 7.79e-02
Hyaluronan metabolism 15 2.95e-02 0.325000 7.88e-02
Signaling by FGFR4 in disease 11 6.28e-02 -0.324000 1.39e-01
MicroRNA (miRNA) biogenesis 23 7.20e-03 0.324000 2.59e-02
Hedgehog 'on' state 75 1.29e-06 0.323000 1.11e-05
Assembly and cell surface presentation of NMDA receptors 18 1.77e-02 -0.323000 5.19e-02
Transport of Ribonucleoproteins into the Host Nucleus 27 3.92e-03 0.321000 1.58e-02
Elevation of cytosolic Ca2+ levels 15 3.18e-02 -0.320000 8.34e-02
Mitotic Prometaphase 179 1.72e-13 0.320000 5.52e-12
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 4.99e-03 -0.318000 1.92e-02
Transcriptional regulation by small RNAs 42 3.62e-04 0.318000 1.92e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.71e-02 0.318000 1.15e-01
Transport of the SLBP Dependant Mature mRNA 31 2.19e-03 0.318000 9.54e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 11 6.84e-02 0.317000 1.49e-01
tRNA processing in the nucleus 51 9.12e-05 0.317000 5.46e-04
Degradation of beta-catenin by the destruction complex 76 1.82e-06 0.317000 1.49e-05
Cardiac conduction 94 1.14e-07 -0.317000 1.14e-06
Non-integrin membrane-ECM interactions 40 5.32e-04 -0.317000 2.67e-03
Nuclear Envelope Breakdown 48 1.55e-04 0.316000 8.87e-04
Collagen chain trimerization 37 9.14e-04 -0.315000 4.40e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.94e-02 -0.314000 1.35e-01
ECM proteoglycans 47 1.97e-04 -0.314000 1.09e-03
Activation of SMO 14 4.24e-02 0.313000 1.06e-01
Assembly of collagen fibrils and other multimeric structures 48 1.77e-04 -0.313000 9.92e-04
Purine ribonucleoside monophosphate biosynthesis 12 6.12e-02 0.312000 1.38e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 12 6.23e-02 -0.311000 1.38e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 12 6.23e-02 -0.311000 1.38e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 80 1.62e-06 0.310000 1.34e-05
Ion homeostasis 42 5.03e-04 -0.310000 2.54e-03
Dual incision in TC-NER 62 2.44e-05 0.310000 1.68e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 8.25e-05 -0.310000 5.03e-04
Mitotic Prophase 77 2.74e-06 0.309000 2.19e-05
Hedgehog 'off' state 90 4.24e-07 0.309000 3.85e-06
Meiotic recombination 25 7.82e-03 0.307000 2.77e-02
Signaling by Leptin 11 7.78e-02 -0.307000 1.67e-01
G2/M DNA damage checkpoint 59 4.72e-05 0.306000 3.02e-04
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 3.44e-02 -0.305000 8.88e-02
Antimicrobial peptides 26 7.11e-03 -0.305000 2.57e-02
Export of Viral Ribonucleoproteins from Nucleus 28 5.24e-03 0.305000 2.00e-02
Nucleobase catabolism 30 3.89e-03 0.305000 1.58e-02
NS1 Mediated Effects on Host Pathways 33 2.47e-03 0.305000 1.06e-02
Transport of the SLBP independent Mature mRNA 30 3.93e-03 0.304000 1.58e-02
Signaling by NOTCH4 75 5.43e-06 0.304000 4.10e-05
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 8.23e-02 0.303000 1.75e-01
Interleukin-2 signaling 11 8.24e-02 -0.302000 1.75e-01
Post-chaperonin tubulin folding pathway 18 2.65e-02 0.302000 7.22e-02
MECP2 regulates neuronal receptors and channels 13 5.99e-02 -0.301000 1.36e-01
PECAM1 interactions 11 8.37e-02 -0.301000 1.77e-01
HIV elongation arrest and recovery 28 5.84e-03 0.301000 2.18e-02
Pausing and recovery of HIV elongation 28 5.84e-03 0.301000 2.18e-02
Diseases of DNA repair 10 9.96e-02 0.301000 2.04e-01
Activation of RAC1 12 7.14e-02 -0.301000 1.55e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 1.48e-02 0.300000 4.49e-02
CRMPs in Sema3A signaling 15 4.46e-02 -0.300000 1.09e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 20 2.08e-02 -0.299000 5.99e-02
Phosphorylation of the APC/C 20 2.09e-02 0.299000 5.99e-02
Muscle contraction 153 2.54e-10 -0.297000 3.73e-09
Late endosomal microautophagy 26 9.29e-03 0.295000 3.17e-02
Syndecan interactions 19 2.61e-02 -0.295000 7.16e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 9.14e-02 0.294000 1.90e-01
Signaling by FGFR3 in disease 14 5.79e-02 -0.293000 1.32e-01
Signaling by FGFR3 point mutants in cancer 14 5.79e-02 -0.293000 1.32e-01
RHO GTPases Activate Formins 113 8.16e-08 0.292000 8.30e-07
Platelet calcium homeostasis 25 1.15e-02 -0.292000 3.72e-02
Regulation of TLR by endogenous ligand 12 8.07e-02 -0.291000 1.72e-01
Eicosanoid ligand-binding receptors 11 9.55e-02 -0.290000 1.97e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 5.18e-02 -0.290000 1.23e-01
Regulation of IFNA signaling 12 8.38e-02 0.288000 1.77e-01
Fertilization 10 1.15e-01 -0.288000 2.26e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 2.58e-02 0.288000 7.09e-02
tRNA Aminoacylation 24 1.47e-02 0.288000 4.47e-02
HIV Infection 206 1.32e-12 0.287000 3.37e-11
Cristae formation 11 1.00e-01 0.286000 2.06e-01
FCERI mediated Ca+2 mobilization 29 7.77e-03 -0.286000 2.77e-02
Uptake and actions of bacterial toxins 28 9.09e-03 -0.285000 3.15e-02
Rap1 signalling 15 5.68e-02 -0.284000 1.31e-01
Molecules associated with elastic fibres 27 1.07e-02 -0.284000 3.50e-02
Formation of the Early Elongation Complex 32 5.49e-03 0.284000 2.07e-02
Formation of the HIV-1 Early Elongation Complex 32 5.49e-03 0.284000 2.07e-02
FOXO-mediated transcription of cell cycle genes 16 4.95e-02 -0.284000 1.19e-01
SUMOylation of SUMOylation proteins 29 8.26e-03 0.283000 2.91e-02
Metabolism of nucleotides 88 4.41e-06 0.283000 3.37e-05
MAPK6/MAPK4 signaling 79 1.38e-05 0.283000 9.86e-05
p130Cas linkage to MAPK signaling for integrins 12 8.96e-02 -0.283000 1.87e-01
CASP8 activity is inhibited 11 1.05e-01 -0.283000 2.11e-01
Dimerization of procaspase-8 11 1.05e-01 -0.283000 2.11e-01
Regulation by c-FLIP 11 1.05e-01 -0.283000 2.11e-01
FCERI mediated NF-kB activation 73 3.17e-05 0.282000 2.13e-04
Global Genome Nucleotide Excision Repair (GG-NER) 80 1.35e-05 0.282000 9.70e-05
Diseases of programmed cell death 23 1.95e-02 0.281000 5.66e-02
Signaling by FGFR3 fusions in cancer 10 1.23e-01 -0.281000 2.38e-01
Budding and maturation of HIV virion 23 2.01e-02 0.280000 5.79e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 27 1.23e-02 -0.278000 3.90e-02
Trafficking of AMPA receptors 27 1.23e-02 -0.278000 3.90e-02
AURKA Activation by TPX2 71 5.23e-05 0.278000 3.31e-04
SARS-CoV-1 Infection 41 2.13e-03 0.277000 9.31e-03
Netrin-1 signaling 46 1.20e-03 -0.276000 5.64e-03
TICAM1, RIP1-mediated IKK complex recruitment 16 5.59e-02 -0.276000 1.30e-01
PIWI-interacting RNA (piRNA) biogenesis 18 4.27e-02 0.276000 1.06e-01
HCMV Infection 74 4.81e-05 0.273000 3.05e-04
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 12 1.01e-01 0.273000 2.07e-01
Transferrin endocytosis and recycling 26 1.64e-02 0.272000 4.86e-02
DNA Repair 268 2.62e-14 0.271000 9.85e-13
Metabolism of amino acids and derivatives 262 9.91e-14 0.268000 3.53e-12
Interleukin-7 signaling 21 3.38e-02 -0.268000 8.76e-02
Translation of structural proteins 26 1.85e-02 0.267000 5.41e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 2.43e-02 -0.266000 6.75e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 38 4.68e-03 0.265000 1.81e-02
RUNX3 regulates NOTCH signaling 14 8.65e-02 -0.265000 1.81e-01
DNA Damage Recognition in GG-NER 35 7.30e-03 0.262000 2.61e-02
Formation of TC-NER Pre-Incision Complex 50 1.37e-03 0.262000 6.38e-03
Ca2+ pathway 54 8.91e-04 -0.262000 4.31e-03
Nucleotide salvage 21 3.82e-02 0.261000 9.72e-02
Loss of Nlp from mitotic centrosomes 68 2.00e-04 0.261000 1.09e-03
Loss of proteins required for interphase microtubule organization from the centrosome 68 2.00e-04 0.261000 1.09e-03
DAG and IP3 signaling 38 5.40e-03 -0.261000 2.05e-02
Nucleotide Excision Repair 105 4.27e-06 0.260000 3.30e-05
RIPK1-mediated regulated necrosis 15 8.16e-02 -0.260000 1.74e-01
Regulated Necrosis 15 8.16e-02 -0.260000 1.74e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 26 2.20e-02 0.260000 6.24e-02
Assembly Of The HIV Virion 13 1.06e-01 0.259000 2.13e-01
Formation of the cornified envelope 24 2.85e-02 -0.258000 7.69e-02
Glycogen metabolism 23 3.20e-02 -0.258000 8.38e-02
Recruitment of NuMA to mitotic centrosomes 79 7.37e-05 0.258000 4.57e-04
Negative regulation of NMDA receptor-mediated neuronal transmission 18 5.81e-02 -0.258000 1.33e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 36 7.45e-03 -0.258000 2.66e-02
Notch-HLH transcription pathway 25 2.62e-02 -0.257000 7.16e-02
IRE1alpha activates chaperones 49 1.89e-03 0.257000 8.39e-03
PI-3K cascade:FGFR2 12 1.24e-01 -0.257000 2.38e-01
SUMOylation of ubiquitinylation proteins 33 1.10e-02 0.256000 3.59e-02
Late Phase of HIV Life Cycle 120 1.41e-06 0.255000 1.20e-05
XBP1(S) activates chaperone genes 47 2.50e-03 0.255000 1.06e-02
FRS-mediated FGFR2 signaling 14 9.86e-02 -0.255000 2.03e-01
Signal regulatory protein family interactions 13 1.12e-01 0.255000 2.21e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 6.16e-02 0.255000 1.38e-01
Amine ligand-binding receptors 18 6.19e-02 -0.254000 1.38e-01
Signaling by ROBO receptors 168 1.38e-08 0.254000 1.57e-07
Telomere C-strand synthesis initiation 12 1.27e-01 0.254000 2.42e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 6.20e-02 -0.254000 1.38e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 38 6.90e-03 0.253000 2.52e-02
HIV Transcription Elongation 38 6.90e-03 0.253000 2.52e-02
Tat-mediated elongation of the HIV-1 transcript 38 6.90e-03 0.253000 2.52e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 22 3.98e-02 0.253000 1.00e-01
Neurodegenerative Diseases 22 3.98e-02 0.253000 1.00e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.01e-01 -0.253000 2.07e-01
Transport of Mature mRNA Derived from an Intronless Transcript 37 7.82e-03 0.253000 2.77e-02
Transcriptional Regulation by E2F6 33 1.25e-02 0.251000 3.91e-02
SLBP independent Processing of Histone Pre-mRNAs 10 1.70e-01 0.251000 3.06e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 5.31e-02 0.250000 1.25e-01
Reduction of cytosolic Ca++ levels 10 1.73e-01 -0.249000 3.11e-01
Signaling by PDGF 51 2.16e-03 -0.248000 9.41e-03
Downstream signaling of activated FGFR2 19 6.15e-02 -0.248000 1.38e-01
mRNA Splicing - Minor Pathway 48 3.01e-03 0.248000 1.25e-02
Gene Silencing by RNA 61 8.61e-04 0.247000 4.22e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.07e-02 0.246000 3.50e-02
Diseases of mitotic cell cycle 36 1.07e-02 0.246000 3.50e-02
RORA activates gene expression 17 7.95e-02 -0.246000 1.70e-01
Signaling by RAF1 mutants 34 1.34e-02 -0.245000 4.15e-02
Mitochondrial calcium ion transport 20 5.91e-02 0.244000 1.35e-01
Elastic fibre formation 37 1.04e-02 -0.244000 3.44e-02
Integrin cell surface interactions 58 1.43e-03 -0.242000 6.58e-03
ERKs are inactivated 13 1.31e-01 0.242000 2.48e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 1.19e-01 -0.240000 2.32e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17 8.65e-02 0.240000 1.81e-01
Regulation of PLK1 Activity at G2/M Transition 84 1.54e-04 0.239000 8.85e-04
TNFR2 non-canonical NF-kB pathway 91 8.41e-05 0.239000 5.10e-04
Regulation of KIT signaling 16 9.89e-02 -0.238000 2.03e-01
Disorders of transmembrane transporters 138 1.50e-06 0.238000 1.26e-05
FRS-mediated FGFR4 signaling 13 1.39e-01 -0.237000 2.58e-01
Centrosome maturation 80 2.51e-04 0.237000 1.36e-03
Recruitment of mitotic centrosome proteins and complexes 80 2.51e-04 0.237000 1.36e-03
Synthesis of PE 11 1.74e-01 -0.237000 3.11e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.33e-02 -0.236000 1.76e-01
PI-3K cascade:FGFR4 11 1.76e-01 -0.236000 3.14e-01
NOTCH2 intracellular domain regulates transcription 11 1.76e-01 -0.235000 3.14e-01
Nephrin family interactions 19 7.60e-02 -0.235000 1.65e-01
HIV Life Cycle 132 3.17e-06 0.235000 2.49e-05
Downstream signaling of activated FGFR4 18 8.49e-02 -0.235000 1.78e-01
Voltage gated Potassium channels 29 2.92e-02 -0.234000 7.83e-02
Iron uptake and transport 50 4.52e-03 0.232000 1.76e-02
Transcriptional regulation by RUNX2 108 3.20e-05 0.232000 2.14e-04
Methylation 11 1.84e-01 0.231000 3.26e-01
HCMV Early Events 54 3.43e-03 0.230000 1.40e-02
Signaling by BMP 23 5.62e-02 -0.230000 1.30e-01
Interleukin receptor SHC signaling 22 6.23e-02 -0.230000 1.38e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 31 2.70e-02 0.230000 7.33e-02
Antiviral mechanism by IFN-stimulated genes 70 9.42e-04 0.229000 4.52e-03
Inhibition of DNA recombination at telomere 20 7.72e-02 0.228000 1.67e-01
Mitochondrial tRNA aminoacylation 18 9.37e-02 0.228000 1.94e-01
Downstream signaling events of B Cell Receptor (BCR) 73 7.53e-04 0.228000 3.73e-03
Anchoring of the basal body to the plasma membrane 92 1.61e-04 0.228000 9.15e-04
Integrin signaling 24 5.47e-02 -0.227000 1.28e-01
Formation of HIV elongation complex in the absence of HIV Tat 40 1.34e-02 0.226000 4.15e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 1.59e-01 0.226000 2.92e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.08e-01 0.225000 2.15e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.08e-01 0.225000 2.15e-01
mRNA decay by 3' to 5' exoribonuclease 15 1.32e-01 0.225000 2.49e-01
MHC class II antigen presentation 95 1.61e-04 0.224000 9.15e-04
HIV Transcription Initiation 45 9.31e-03 0.224000 3.17e-02
RNA Polymerase II HIV Promoter Escape 45 9.31e-03 0.224000 3.17e-02
RNA Polymerase II Promoter Escape 45 9.31e-03 0.224000 3.17e-02
RNA Polymerase II Transcription Initiation 45 9.31e-03 0.224000 3.17e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 9.31e-03 0.224000 3.17e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 9.31e-03 0.224000 3.17e-02
Regulation of TP53 Activity through Phosphorylation 86 3.33e-04 0.224000 1.79e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 1.50e-01 0.222000 2.78e-01
Interconversion of nucleotide di- and triphosphates 26 5.04e-02 0.222000 1.21e-01
NOD1/2 Signaling Pathway 30 3.59e-02 -0.221000 9.19e-02
TP53 Regulates Transcription of DNA Repair Genes 57 3.95e-03 0.221000 1.58e-02
Transcriptional activation of mitochondrial biogenesis 50 7.06e-03 -0.220000 2.55e-02
Cyclin D associated events in G1 43 1.28e-02 0.219000 4.00e-02
G1 Phase 43 1.28e-02 0.219000 4.00e-02
Regulation of MECP2 expression and activity 29 4.11e-02 -0.219000 1.03e-01
SHC-mediated cascade:FGFR2 12 1.89e-01 -0.219000 3.33e-01
ISG15 antiviral mechanism 62 2.95e-03 0.218000 1.23e-02
Signaling by Hedgehog 120 3.90e-05 0.218000 2.54e-04
CaM pathway 32 3.43e-02 -0.216000 8.86e-02
Calmodulin induced events 32 3.43e-02 -0.216000 8.86e-02
Interleukin-2 family signaling 37 2.30e-02 -0.216000 6.47e-02
Meiosis 52 7.21e-03 0.216000 2.59e-02
PLC beta mediated events 47 1.07e-02 -0.215000 3.50e-02
Gap junction trafficking 14 1.64e-01 0.215000 2.98e-01
Carnitine metabolism 12 2.00e-01 -0.214000 3.49e-01
Interleukin-1 signaling 92 4.04e-04 0.214000 2.10e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling 39 2.13e-02 -0.213000 6.06e-02
TRP channels 18 1.18e-01 -0.213000 2.30e-01
Depolymerisation of the Nuclear Lamina 15 1.54e-01 0.213000 2.84e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 6.07e-02 0.213000 1.37e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 6.07e-02 0.213000 1.37e-01
Regulation of TNFR1 signaling 27 5.66e-02 -0.212000 1.31e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 2.47e-02 -0.211000 6.82e-02
Signaling by RAS mutants 38 2.47e-02 -0.211000 6.82e-02
Signaling by moderate kinase activity BRAF mutants 38 2.47e-02 -0.211000 6.82e-02
Signaling downstream of RAS mutants 38 2.47e-02 -0.211000 6.82e-02
Downstream signaling of activated FGFR3 17 1.33e-01 -0.210000 2.49e-01
Sialic acid metabolism 26 6.42e-02 0.210000 1.42e-01
RNA Polymerase III Chain Elongation 18 1.24e-01 0.210000 2.38e-01
Signaling by KIT in disease 20 1.05e-01 -0.210000 2.11e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 1.05e-01 -0.210000 2.11e-01
IKK complex recruitment mediated by RIP1 20 1.07e-01 -0.208000 2.14e-01
Binding and Uptake of Ligands by Scavenger Receptors 33 3.87e-02 0.208000 9.80e-02
Neurotransmitter release cycle 34 3.66e-02 -0.207000 9.35e-02
Lysosome Vesicle Biogenesis 32 4.27e-02 0.207000 1.06e-01
TNF signaling 37 2.97e-02 -0.207000 7.93e-02
Transport of inorganic cations/anions and amino acids/oligopeptides 77 1.80e-03 -0.206000 8.05e-03
Senescence-Associated Secretory Phenotype (SASP) 46 1.59e-02 0.206000 4.77e-02
DCC mediated attractive signaling 13 2.01e-01 -0.205000 3.49e-01
DNA Damage/Telomere Stress Induced Senescence 27 6.53e-02 0.205000 1.44e-01
Diseases associated with glycosylation precursor biosynthesis 18 1.32e-01 0.205000 2.49e-01
Keratinization 31 4.84e-02 -0.205000 1.17e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 7.63e-02 0.205000 1.65e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 33 4.29e-02 -0.204000 1.06e-01
DNA Double Strand Break Response 38 3.01e-02 0.203000 7.98e-02
FRS-mediated FGFR3 signaling 12 2.23e-01 -0.203000 3.77e-01
Post NMDA receptor activation events 54 9.96e-03 -0.203000 3.35e-02
Major pathway of rRNA processing in the nucleolus and cytosol 141 3.56e-05 0.202000 2.35e-04
G alpha (q) signalling events 147 2.62e-05 -0.201000 1.79e-04
NCAM1 interactions 32 5.00e-02 -0.200000 1.20e-01
Purine salvage 13 2.12e-01 0.200000 3.62e-01
Circadian Clock 63 6.24e-03 -0.199000 2.32e-02
Activated NTRK2 signals through FRS2 and FRS3 10 2.75e-01 -0.199000 4.40e-01
Activation of NMDA receptors and postsynaptic events 62 6.92e-03 -0.198000 2.52e-02
Other semaphorin interactions 19 1.36e-01 -0.198000 2.54e-01
Formation of the beta-catenin:TCF transactivating complex 31 5.69e-02 -0.198000 1.31e-01
Neurexins and neuroligins 42 2.70e-02 -0.197000 7.33e-02
Interferon Signaling 147 3.79e-05 0.197000 2.47e-04
Cytosolic sulfonation of small molecules 17 1.60e-01 0.197000 2.93e-01
Regulation of RUNX1 Expression and Activity 17 1.60e-01 -0.197000 2.93e-01
G-protein mediated events 48 1.85e-02 -0.197000 5.41e-02
Transmission across Chemical Synapses 185 4.32e-06 -0.196000 3.32e-05
Signaling by NODAL 17 1.61e-01 0.196000 2.94e-01
Downstream signal transduction 29 6.79e-02 -0.196000 1.49e-01
Calnexin/calreticulin cycle 23 1.04e-01 0.196000 2.11e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 1.42e-01 -0.195000 2.63e-01
PI-3K cascade:FGFR3 10 2.86e-01 -0.195000 4.52e-01
Unfolded Protein Response (UPR) 85 1.93e-03 0.195000 8.54e-03
SHC-mediated cascade:FGFR4 11 2.64e-01 -0.195000 4.26e-01
Tight junction interactions 13 2.25e-01 -0.194000 3.79e-01
Interleukin-21 signaling 10 2.87e-01 -0.194000 4.53e-01
Olfactory Signaling Pathway 15 1.93e-01 0.194000 3.39e-01
Blood group systems biosynthesis 16 1.80e-01 0.194000 3.20e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 1.24e-02 0.193000 3.90e-02
Ca-dependent events 34 5.14e-02 -0.193000 1.22e-01
Na+/Cl- dependent neurotransmitter transporters 14 2.13e-01 -0.192000 3.63e-01
Cell junction organization 60 1.00e-02 -0.192000 3.37e-02
Cellular responses to external stimuli 435 7.99e-12 0.192000 1.66e-10
Membrane binding and targetting of GAG proteins 11 2.70e-01 0.192000 4.33e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 11 2.70e-01 0.192000 4.33e-01
Synthesis of PIPs at the late endosome membrane 11 2.71e-01 -0.192000 4.34e-01
Signaling by FGFR1 in disease 31 6.51e-02 -0.191000 1.44e-01
Neuronal System 274 6.06e-08 -0.191000 6.35e-07
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 10 2.98e-01 -0.190000 4.67e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 2.98e-02 -0.189000 7.93e-02
O-glycosylation of TSR domain-containing proteins 34 5.62e-02 -0.189000 1.30e-01
mRNA Capping 28 8.40e-02 0.189000 1.77e-01
Regulation of Complement cascade 36 5.03e-02 0.189000 1.21e-01
Cellular responses to stress 431 2.41e-11 0.189000 4.53e-10
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 2.39e-01 -0.188000 3.96e-01
Chaperone Mediated Autophagy 17 1.79e-01 0.188000 3.18e-01
TP53 Regulates Transcription of Cell Death Genes 38 4.54e-02 -0.188000 1.11e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 2.63e-02 0.187000 7.16e-02
Platelet sensitization by LDL 15 2.10e-01 0.187000 3.61e-01
Activation of Matrix Metalloproteinases 25 1.06e-01 -0.187000 2.12e-01
SUMOylation of DNA damage response and repair proteins 66 8.66e-03 0.187000 3.01e-02
rRNA processing in the nucleus and cytosol 150 7.96e-05 0.187000 4.87e-04
Protein-protein interactions at synapses 62 1.10e-02 -0.187000 3.59e-02
SUMOylation of transcription factors 15 2.11e-01 -0.187000 3.62e-01
Glucuronidation 10 3.08e-01 -0.186000 4.79e-01
FGFR2 mutant receptor activation 21 1.41e-01 0.186000 2.62e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 23 1.25e-01 0.185000 2.40e-01
Role of phospholipids in phagocytosis 28 9.16e-02 0.184000 1.90e-01
Gap junction trafficking and regulation 16 2.03e-01 0.184000 3.52e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 37 5.42e-02 0.183000 1.27e-01
Signal attenuation 10 3.17e-01 -0.183000 4.89e-01
Protein localization 145 1.51e-04 0.183000 8.77e-04
Plasma lipoprotein assembly 13 2.55e-01 0.183000 4.15e-01
Regulation of insulin secretion 64 1.16e-02 -0.183000 3.74e-02
TNFR1-induced NFkappaB signaling pathway 24 1.22e-01 -0.183000 2.36e-01
p38MAPK events 13 2.55e-01 -0.182000 4.15e-01
GRB2 events in ERBB2 signaling 14 2.38e-01 -0.182000 3.94e-01
Signaling by Erythropoietin 24 1.22e-01 -0.182000 2.37e-01
Regulation of FZD by ubiquitination 16 2.08e-01 -0.182000 3.59e-01
SHC1 events in ERBB4 signaling 12 2.76e-01 -0.182000 4.40e-01
Formation of RNA Pol II elongation complex 53 2.23e-02 0.182000 6.28e-02
RNA Polymerase II Transcription Elongation 53 2.23e-02 0.182000 6.28e-02
Ion transport by P-type ATPases 38 5.32e-02 -0.181000 1.25e-01
MET promotes cell motility 29 9.16e-02 -0.181000 1.90e-01
Collagen formation 76 6.46e-03 -0.181000 2.39e-02
Cytosolic iron-sulfur cluster assembly 11 3.01e-01 0.180000 4.72e-01
ATF4 activates genes in response to endoplasmic reticulum stress 24 1.27e-01 0.180000 2.42e-01
Intrinsic Pathway for Apoptosis 46 3.46e-02 0.180000 8.90e-02
RNA Polymerase III Transcription Termination 23 1.36e-01 0.179000 2.54e-01
Transcriptional Regulation by MECP2 50 2.86e-02 -0.179000 7.71e-02
CS/DS degradation 13 2.64e-01 0.179000 4.26e-01
PERK regulates gene expression 28 1.02e-01 0.179000 2.08e-01
Transcription of the HIV genome 64 1.36e-02 0.178000 4.22e-02
SUMOylation of RNA binding proteins 41 4.87e-02 0.178000 1.18e-01
Signaling by MET 64 1.40e-02 -0.178000 4.30e-02
IL-6-type cytokine receptor ligand interactions 14 2.50e-01 -0.177000 4.11e-01
Constitutive Signaling by EGFRvIII 15 2.34e-01 -0.177000 3.90e-01
Signaling by EGFRvIII in Cancer 15 2.34e-01 -0.177000 3.90e-01
FOXO-mediated transcription of cell death genes 15 2.36e-01 0.177000 3.91e-01
Stimuli-sensing channels 67 1.25e-02 -0.177000 3.92e-02
SARS-CoV Infections 76 7.85e-03 0.177000 2.77e-02
Termination of O-glycan biosynthesis 14 2.54e-01 0.176000 4.15e-01
SHC1 events in ERBB2 signaling 20 1.76e-01 -0.175000 3.13e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 69 1.24e-02 0.174000 3.90e-02
PTEN Regulation 131 5.88e-04 0.174000 2.95e-03
Extracellular matrix organization 246 2.79e-06 -0.174000 2.22e-05
InlB-mediated entry of Listeria monocytogenes into host cell 13 2.78e-01 -0.174000 4.42e-01
CLEC7A (Dectin-1) signaling 90 4.43e-03 0.174000 1.74e-02
RMTs methylate histone arginines 29 1.07e-01 0.173000 2.14e-01
Branched-chain amino acid catabolism 21 1.71e-01 -0.173000 3.08e-01
RNA Polymerase II Pre-transcription Events 75 1.00e-02 0.172000 3.36e-02
Signaling by NTRK2 (TRKB) 23 1.56e-01 -0.171000 2.87e-01
Negative epigenetic regulation of rRNA expression 48 4.10e-02 0.171000 1.03e-01
Cilium Assembly 173 1.17e-04 0.170000 6.86e-04
NoRC negatively regulates rRNA expression 45 4.84e-02 0.170000 1.17e-01
Signaling by NOTCH1 67 1.61e-02 -0.170000 4.79e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 2.55e-01 0.170000 4.15e-01
Meiotic synapsis 29 1.14e-01 0.170000 2.25e-01
RNA Polymerase I Promoter Clearance 48 4.22e-02 0.170000 1.05e-01
Complex I biogenesis 54 3.33e-02 0.168000 8.69e-02
Apoptosis 154 3.42e-04 0.168000 1.82e-03
Signaling by EGFR 45 5.32e-02 -0.167000 1.25e-01
Retrograde transport at the Trans-Golgi-Network 44 5.61e-02 -0.167000 1.30e-01
FGFR2 alternative splicing 23 1.68e-01 0.166000 3.04e-01
Signaling by SCF-KIT 43 6.05e-02 -0.166000 1.37e-01
Neurotransmitter receptors and postsynaptic signal transmission 136 8.81e-04 -0.165000 4.29e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.30e-01 0.165000 2.45e-01
Programmed Cell Death 157 3.70e-04 0.165000 1.94e-03
Receptor-type tyrosine-protein phosphatases 12 3.24e-01 -0.164000 4.96e-01
COPI-dependent Golgi-to-ER retrograde traffic 75 1.42e-02 0.164000 4.34e-02
GPVI-mediated activation cascade 32 1.09e-01 -0.164000 2.16e-01
Signaling by WNT in cancer 31 1.17e-01 -0.163000 2.30e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 65 2.41e-02 0.162000 6.74e-02
Glutathione conjugation 31 1.19e-01 0.162000 2.32e-01
Incretin synthesis, secretion, and inactivation 14 2.95e-01 -0.162000 4.65e-01
RNA Polymerase I Promoter Escape 30 1.27e-01 0.161000 2.42e-01
Transport of Mature Transcript to Cytoplasm 74 1.75e-02 0.160000 5.15e-02
FGFR1 mutant receptor activation 24 1.75e-01 -0.160000 3.13e-01
Nucleotide-like (purinergic) receptors 13 3.18e-01 -0.160000 4.91e-01
Interleukin-10 signaling 37 9.30e-02 0.160000 1.92e-01
DSCAM interactions 10 3.83e-01 -0.159000 5.64e-01
Respiratory electron transport 97 6.81e-03 0.159000 2.52e-02
FCGR3A-mediated IL10 synthesis 41 7.84e-02 0.159000 1.68e-01
IRS-mediated signalling 35 1.04e-01 -0.159000 2.11e-01
RHO GTPases activate IQGAPs 11 3.66e-01 0.157000 5.45e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 48 5.97e-02 -0.157000 1.35e-01
Synthesis of substrates in N-glycan biosythesis 55 4.54e-02 0.156000 1.11e-01
FRS-mediated FGFR1 signaling 13 3.30e-01 -0.156000 5.04e-01
Telomere Extension By Telomerase 22 2.06e-01 0.156000 3.57e-01
Peptide hormone metabolism 56 4.42e-02 -0.156000 1.09e-01
Acyl chain remodelling of PC 22 2.08e-01 0.155000 3.59e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 2.83e-01 -0.155000 4.49e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 5.12e-02 -0.155000 1.22e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 5.12e-02 -0.155000 1.22e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 5.12e-02 -0.155000 1.22e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 5.12e-02 -0.155000 1.22e-01
Signaling by NOTCH1 in Cancer 53 5.12e-02 -0.155000 1.22e-01
Golgi-to-ER retrograde transport 106 5.98e-03 0.155000 2.23e-02
Regulation of TP53 Activity 148 1.23e-03 0.154000 5.76e-03
Asparagine N-linked glycosylation 257 2.20e-05 0.154000 1.53e-04
Endogenous sterols 20 2.33e-01 -0.154000 3.90e-01
Synthesis of PIPs at the plasma membrane 51 5.73e-02 -0.154000 1.32e-01
Processing of Capped Intron-Containing Pre-mRNA 220 8.75e-05 0.154000 5.29e-04
Thromboxane signalling through TP receptor 20 2.34e-01 0.154000 3.90e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 10 4.02e-01 -0.153000 5.85e-01
RNA Polymerase I Transcription 49 6.44e-02 0.153000 1.42e-01
Signaling by BRAF and RAF fusions 55 5.04e-02 -0.153000 1.21e-01
Infectious disease 599 2.79e-10 0.152000 4.02e-09
Mitotic Telophase/Cytokinesis 12 3.63e-01 0.152000 5.40e-01
CTLA4 inhibitory signaling 21 2.29e-01 0.152000 3.85e-01
Signaling by high-kinase activity BRAF mutants 29 1.60e-01 -0.151000 2.93e-01
Signaling by ERBB2 in Cancer 23 2.11e-01 -0.151000 3.62e-01
Degradation of the extracellular matrix 87 1.55e-02 -0.150000 4.67e-02
RHO GTPases activate PAKs 21 2.33e-01 -0.150000 3.90e-01
COPI-mediated anterograde transport 79 2.11e-02 0.150000 6.05e-02
Tie2 Signaling 17 2.85e-01 -0.150000 4.51e-01
SHC-mediated cascade:FGFR3 10 4.13e-01 -0.150000 5.95e-01
WNT ligand biogenesis and trafficking 20 2.47e-01 0.150000 4.06e-01
Cargo concentration in the ER 26 1.88e-01 0.149000 3.33e-01
NRAGE signals death through JNK 56 5.43e-02 -0.149000 1.27e-01
Collagen biosynthesis and modifying enzymes 56 5.56e-02 -0.148000 1.29e-01
Regulation of HSF1-mediated heat shock response 70 3.26e-02 0.148000 8.50e-02
ROS and RNS production in phagocytes 30 1.62e-01 0.147000 2.95e-01
Signaling by ERBB2 KD Mutants 22 2.32e-01 -0.147000 3.89e-01
Oncogenic MAPK signaling 72 3.10e-02 -0.147000 8.20e-02
VxPx cargo-targeting to cilium 18 2.80e-01 0.147000 4.45e-01
mRNA Splicing - Major Pathway 167 1.09e-03 0.147000 5.17e-03
MAP2K and MAPK activation 33 1.46e-01 -0.146000 2.70e-01
NRIF signals cell death from the nucleus 14 3.45e-01 0.146000 5.21e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.91e-01 0.145000 3.36e-01
Insulin receptor signalling cascade 41 1.08e-01 -0.145000 2.15e-01
Deactivation of the beta-catenin transactivating complex 35 1.38e-01 -0.145000 2.58e-01
COPII-mediated vesicle transport 62 4.91e-02 0.145000 1.19e-01
FOXO-mediated transcription 56 6.17e-02 -0.144000 1.38e-01
ERBB2 Activates PTK6 Signaling 11 4.08e-01 -0.144000 5.92e-01
Metabolism of steroids 114 8.38e-03 -0.143000 2.94e-02
Diseases associated with O-glycosylation of proteins 51 7.72e-02 -0.143000 1.67e-01
Downstream TCR signaling 83 2.44e-02 0.143000 6.79e-02
Pre-NOTCH Processing in Golgi 16 3.23e-01 0.143000 4.95e-01
VEGFA-VEGFR2 Pathway 92 1.87e-02 -0.142000 5.44e-02
Fatty acyl-CoA biosynthesis 25 2.19e-01 -0.142000 3.73e-01
SUMOylation of transcription cofactors 39 1.26e-01 -0.142000 2.42e-01
Metabolism of RNA 601 4.15e-09 0.141000 5.29e-08
Cargo trafficking to the periciliary membrane 45 1.02e-01 0.141000 2.08e-01
G alpha (z) signalling events 39 1.28e-01 -0.141000 2.44e-01
Nonhomologous End-Joining (NHEJ) 33 1.62e-01 0.141000 2.95e-01
WNT5A-dependent internalization of FZD4 15 3.46e-01 0.141000 5.21e-01
mTORC1-mediated signalling 23 2.44e-01 0.141000 4.01e-01
Glycosphingolipid metabolism 34 1.57e-01 0.140000 2.87e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 103 1.43e-02 0.140000 4.36e-02
PI-3K cascade:FGFR1 11 4.22e-01 -0.140000 6.05e-01
PI3K events in ERBB2 signaling 14 3.67e-01 -0.139000 5.45e-01
RHO GTPases Activate NADPH Oxidases 22 2.59e-01 -0.139000 4.20e-01
Signaling by Activin 11 4.26e-01 -0.139000 6.07e-01
Cell-Cell communication 91 2.28e-02 -0.138000 6.40e-02
mRNA Splicing 175 1.71e-03 0.138000 7.75e-03
HS-GAG biosynthesis 23 2.54e-01 0.137000 4.15e-01
Prostacyclin signalling through prostacyclin receptor 15 3.58e-01 0.137000 5.35e-01
Regulated proteolysis of p75NTR 11 4.34e-01 0.136000 6.15e-01
Signaling by NOTCH2 29 2.04e-01 -0.136000 3.54e-01
RNA Polymerase I Transcription Initiation 45 1.14e-01 0.136000 2.26e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 32 1.83e-01 -0.136000 3.25e-01
Platelet homeostasis 74 4.42e-02 -0.135000 1.09e-01
Interleukin-6 family signaling 20 2.97e-01 -0.135000 4.67e-01
Reproduction 62 6.77e-02 0.134000 1.48e-01
PI3K Cascade 31 1.96e-01 -0.134000 3.43e-01
Mitochondrial biogenesis 69 5.52e-02 -0.134000 1.29e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.05e-01 -0.133000 5.88e-01
Nicotinate metabolism 26 2.40e-01 -0.133000 3.96e-01
Signaling by VEGF 100 2.16e-02 -0.133000 6.12e-02
SUMOylation of chromatin organization proteins 49 1.08e-01 0.133000 2.15e-01
Inactivation, recovery and regulation of the phototransduction cascade 24 2.60e-01 -0.133000 4.21e-01
The phototransduction cascade 24 2.60e-01 -0.133000 4.21e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 40 1.48e-01 -0.132000 2.73e-01
Signaling by ERBB2 TMD/JMD mutants 19 3.19e-01 -0.132000 4.91e-01
GPCR downstream signalling 477 9.25e-07 -0.132000 8.13e-06
Protein methylation 11 4.51e-01 0.131000 6.33e-01
Potassium Channels 66 6.56e-02 -0.131000 1.44e-01
Nuclear Receptor transcription pathway 44 1.32e-01 -0.131000 2.49e-01
TNFR1-induced proapoptotic signaling 13 4.14e-01 -0.131000 5.95e-01
COPI-independent Golgi-to-ER retrograde traffic 31 2.08e-01 0.131000 3.59e-01
Activation of HOX genes during differentiation 58 8.53e-02 0.131000 1.79e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 58 8.53e-02 0.131000 1.79e-01
Beta-catenin independent WNT signaling 131 1.02e-02 0.130000 3.39e-02
EPHA-mediated growth cone collapse 14 3.99e-01 -0.130000 5.83e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 4.77e-01 0.130000 6.54e-01
ER to Golgi Anterograde Transport 126 1.20e-02 0.130000 3.83e-02
Caspase activation via Death Receptors in the presence of ligand 16 3.70e-01 -0.130000 5.47e-01
Defective B4GALT7 causes EDS, progeroid type 18 3.41e-01 -0.130000 5.18e-01
RET signaling 35 1.85e-01 -0.129000 3.28e-01
Integration of energy metabolism 94 3.06e-02 -0.129000 8.09e-02
Triglyceride metabolism 25 2.64e-01 -0.129000 4.26e-01
Beta-oxidation of very long chain fatty acids 10 4.81e-01 0.129000 6.56e-01
Downstream signaling of activated FGFR1 21 3.11e-01 -0.128000 4.82e-01
Dectin-2 family 15 3.92e-01 0.128000 5.73e-01
IRS-related events triggered by IGF1R 38 1.73e-01 -0.128000 3.11e-01
Interleukin-1 family signaling 120 1.61e-02 0.127000 4.79e-02
rRNA processing 167 4.60e-03 0.127000 1.78e-02
Transcriptional regulation of granulopoiesis 31 2.23e-01 0.127000 3.76e-01
DARPP-32 events 21 3.15e-01 0.127000 4.88e-01
MyD88 deficiency (TLR2/4) 10 4.88e-01 0.127000 6.63e-01
Spry regulation of FGF signaling 14 4.14e-01 0.126000 5.95e-01
Glycolysis 60 9.21e-02 0.126000 1.91e-01
RHO GTPases activate PKNs 33 2.13e-01 -0.125000 3.64e-01
IRAK4 deficiency (TLR2/4) 11 4.72e-01 0.125000 6.52e-01
Negative regulation of MET activity 19 3.46e-01 -0.125000 5.21e-01
C-type lectin receptors (CLRs) 117 1.98e-02 0.125000 5.74e-02
Prolonged ERK activation events 13 4.38e-01 -0.124000 6.20e-01
Ion channel transport 122 1.82e-02 -0.124000 5.34e-02
Autophagy 117 2.10e-02 0.124000 6.03e-02
Phase II - Conjugation of compounds 73 6.82e-02 0.124000 1.49e-01
Gluconeogenesis 26 2.76e-01 -0.124000 4.40e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.78e-01 -0.123000 6.54e-01
NCAM signaling for neurite out-growth 52 1.24e-01 -0.123000 2.38e-01
Rho GTPase cycle 132 1.46e-02 -0.123000 4.44e-02
Glycosaminoglycan metabolism 99 3.45e-02 0.123000 8.88e-02
Signalling to RAS 18 3.68e-01 -0.123000 5.46e-01
Ovarian tumor domain proteases 35 2.13e-01 -0.122000 3.63e-01
EGFR downregulation 26 2.83e-01 -0.122000 4.49e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 3.47e-01 0.122000 5.21e-01
CD209 (DC-SIGN) signaling 19 3.59e-01 -0.121000 5.37e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 17 3.87e-01 -0.121000 5.68e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 17 3.87e-01 -0.121000 5.68e-01
Apoptotic cleavage of cellular proteins 35 2.17e-01 -0.121000 3.69e-01
Interleukin-6 signaling 10 5.10e-01 -0.120000 6.84e-01
Signaling by ERBB2 ECD mutants 15 4.21e-01 -0.120000 6.04e-01
RNA Polymerase I Transcription Termination 30 2.56e-01 0.120000 4.16e-01
Signaling by Retinoic Acid 34 2.30e-01 -0.119000 3.86e-01
Cell-cell junction organization 35 2.26e-01 -0.118000 3.81e-01
Cell recruitment (pro-inflammatory response) 22 3.37e-01 0.118000 5.14e-01
Purinergic signaling in leishmaniasis infection 22 3.37e-01 0.118000 5.14e-01
Transcriptional Regulation by TP53 335 2.18e-04 0.118000 1.19e-03
Base-Excision Repair, AP Site Formation 18 3.86e-01 0.118000 5.68e-01
Transcriptional regulation by RUNX3 89 5.53e-02 0.118000 1.29e-01
Processing of Capped Intronless Pre-mRNA 26 3.02e-01 0.117000 4.72e-01
Class B/2 (Secretin family receptors) 57 1.27e-01 0.117000 2.42e-01
Activated NOTCH1 Transmits Signal to the Nucleus 26 3.03e-01 -0.117000 4.73e-01
Costimulation by the CD28 family 61 1.17e-01 -0.116000 2.30e-01
Signalling to ERKs 31 2.66e-01 -0.115000 4.28e-01
Lewis blood group biosynthesis 13 4.72e-01 0.115000 6.52e-01
trans-Golgi Network Vesicle Budding 67 1.04e-01 0.115000 2.11e-01
Signaling by the B Cell Receptor (BCR) 104 4.34e-02 0.115000 1.07e-01
Apoptotic execution phase 43 1.98e-01 -0.113000 3.47e-01
Scavenging by Class A Receptors 14 4.63e-01 0.113000 6.44e-01
PI Metabolism 79 8.39e-02 -0.113000 1.77e-01
Interferon gamma signaling 65 1.18e-01 0.112000 2.30e-01
Myogenesis 24 3.43e-01 -0.112000 5.20e-01
Pyruvate metabolism 26 3.24e-01 -0.112000 4.96e-01
Listeria monocytogenes entry into host cells 18 4.13e-01 -0.112000 5.95e-01
Deadenylation of mRNA 24 3.46e-01 -0.111000 5.21e-01
PKA activation in glucagon signalling 15 4.56e-01 0.111000 6.38e-01
Cleavage of the damaged pyrimidine 16 4.43e-01 0.111000 6.25e-01
Depyrimidination 16 4.43e-01 0.111000 6.25e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 4.43e-01 0.111000 6.25e-01
Metabolism of carbohydrates 239 3.27e-03 0.111000 1.34e-02
IGF1R signaling cascade 39 2.32e-01 -0.111000 3.88e-01
Synthesis, secretion, and deacylation of Ghrelin 14 4.73e-01 0.111000 6.52e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 84 7.97e-02 -0.111000 1.71e-01
EPH-ephrin mediated repulsion of cells 43 2.10e-01 0.111000 3.61e-01
Mitophagy 25 3.39e-01 0.111000 5.16e-01
Cleavage of the damaged purine 11 5.27e-01 0.110000 6.96e-01
Depurination 11 5.27e-01 0.110000 6.96e-01
Recognition and association of DNA glycosylase with site containing an affected purine 11 5.27e-01 0.110000 6.96e-01
Ephrin signaling 19 4.11e-01 -0.109000 5.94e-01
Transcriptional regulation by RUNX1 164 1.64e-02 0.109000 4.86e-02
Amino acid transport across the plasma membrane 29 3.11e-01 -0.109000 4.82e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 4.01e-01 -0.108000 5.84e-01
Regulation of signaling by CBL 18 4.26e-01 -0.108000 6.07e-01
Biotin transport and metabolism 11 5.34e-01 -0.108000 7.02e-01
Platelet activation, signaling and aggregation 228 5.07e-03 -0.108000 1.94e-02
Neddylation 212 6.93e-03 0.108000 2.52e-02
ER Quality Control Compartment (ERQC) 18 4.30e-01 0.107000 6.11e-01
Signaling by NOTCH 162 1.87e-02 0.107000 5.44e-02
PKMTs methylate histone lysines 37 2.59e-01 -0.107000 4.20e-01
SLC-mediated transmembrane transport 178 1.38e-02 -0.107000 4.26e-02
FCERI mediated MAPK activation 31 3.04e-01 -0.107000 4.74e-01
G beta:gamma signalling through BTK 14 4.91e-01 0.106000 6.65e-01
Class A/1 (Rhodopsin-like receptors) 171 1.67e-02 -0.106000 4.94e-02
Transport to the Golgi and subsequent modification 152 2.41e-02 0.106000 6.74e-02
Formation of tubulin folding intermediates by CCT/TriC 21 4.00e-01 0.106000 5.83e-01
RAS processing 19 4.24e-01 0.106000 6.06e-01
Macroautophagy 103 6.34e-02 0.106000 1.40e-01
Metabolic disorders of biological oxidation enzymes 23 3.80e-01 -0.106000 5.61e-01
Metabolism of proteins 1615 4.71e-12 0.106000 1.12e-10
Neutrophil degranulation 392 3.83e-04 0.105000 2.00e-03
Prefoldin mediated transfer of substrate to CCT/TriC 26 3.54e-01 0.105000 5.31e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 40 2.52e-01 -0.105000 4.13e-01
Death Receptor Signalling 127 4.29e-02 -0.104000 1.06e-01
Aggrephagy 18 4.45e-01 0.104000 6.27e-01
Dermatan sulfate biosynthesis 10 5.70e-01 0.104000 7.31e-01
Intraflagellar transport 38 2.68e-01 0.104000 4.31e-01
MTOR signalling 39 2.62e-01 0.104000 4.24e-01
ADP signalling through P2Y purinoceptor 1 21 4.11e-01 0.104000 5.94e-01
Collagen degradation 31 3.19e-01 -0.103000 4.91e-01
Heparan sulfate/heparin (HS-GAG) metabolism 42 2.47e-01 0.103000 4.06e-01
Signaling by GPCR 520 6.36e-05 -0.103000 3.99e-04
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 4.62e-01 -0.103000 6.44e-01
Positive epigenetic regulation of rRNA expression 45 2.34e-01 0.103000 3.90e-01
Interleukin-35 Signalling 12 5.39e-01 -0.102000 7.04e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 5.26e-01 0.102000 6.96e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 10 5.78e-01 -0.102000 7.35e-01
Bile acid and bile salt metabolism 25 3.81e-01 0.101000 5.61e-01
Complement cascade 42 2.56e-01 0.101000 4.16e-01
RHO GTPases activate KTN1 11 5.61e-01 -0.101000 7.22e-01
CD28 co-stimulation 32 3.22e-01 -0.101000 4.94e-01
PINK1-PRKN Mediated Mitophagy 18 4.58e-01 0.101000 6.40e-01
The canonical retinoid cycle in rods (twilight vision) 14 5.13e-01 -0.101000 6.84e-01
A tetrasaccharide linker sequence is required for GAG synthesis 22 4.12e-01 -0.101000 5.95e-01
Regulation of TP53 Activity through Acetylation 29 3.47e-01 0.101000 5.21e-01
Glucose metabolism 76 1.29e-01 0.101000 2.45e-01
Cellular hexose transport 12 5.46e-01 -0.101000 7.11e-01
TCF dependent signaling in response to WNT 151 3.37e-02 0.100000 8.76e-02
SUMOylation of intracellular receptors 26 3.76e-01 -0.100000 5.56e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.84e-01 0.100000 7.36e-01
Assembly of active LPL and LIPC lipase complexes 15 5.03e-01 -0.099800 6.77e-01
Interleukin-17 signaling 65 1.64e-01 -0.099800 2.98e-01
Semaphorin interactions 63 1.71e-01 -0.099800 3.08e-01
Glyoxylate metabolism and glycine degradation 26 3.80e-01 -0.099500 5.61e-01
Constitutive Signaling by Aberrant PI3K in Cancer 58 1.91e-01 -0.099400 3.35e-01
Interleukin-37 signaling 19 4.54e-01 -0.099300 6.36e-01
Zinc transporters 14 5.21e-01 -0.099100 6.93e-01
Killing mechanisms 11 5.70e-01 0.098900 7.31e-01
WNT5:FZD7-mediated leishmania damping 11 5.70e-01 0.098900 7.31e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 5.37e-01 -0.098800 7.03e-01
SHC-mediated cascade:FGFR1 11 5.71e-01 -0.098700 7.31e-01
P2Y receptors 10 5.90e-01 -0.098500 7.41e-01
tRNA processing 106 8.04e-02 0.098400 1.72e-01
Toll Like Receptor 3 (TLR3) Cascade 87 1.14e-01 -0.098200 2.25e-01
SUMOylation of DNA methylation proteins 16 4.98e-01 -0.098000 6.72e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 22 4.27e-01 0.097800 6.07e-01
Protein ubiquitination 56 2.09e-01 0.097100 3.61e-01
Activation of the AP-1 family of transcription factors 10 6.00e-01 -0.095700 7.48e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 14 5.36e-01 0.095600 7.03e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 2.43e-01 -0.095500 4.01e-01
G alpha (i) signalling events 251 9.81e-03 -0.095000 3.31e-02
RAF activation 34 3.40e-01 -0.094600 5.17e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.88e-01 0.094300 5.68e-01
Formation of Incision Complex in GG-NER 40 3.02e-01 0.094300 4.73e-01
Triglyceride catabolism 17 5.03e-01 -0.093800 6.77e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 4.27e-01 -0.093700 6.07e-01
HSF1 activation 24 4.27e-01 0.093600 6.07e-01
MyD88-independent TLR4 cascade 91 1.24e-01 -0.093400 2.38e-01
TRIF(TICAM1)-mediated TLR4 signaling 91 1.24e-01 -0.093400 2.38e-01
Erythropoietin activates RAS 13 5.60e-01 -0.093300 7.22e-01
Glucagon signaling in metabolic regulation 26 4.11e-01 0.093200 5.94e-01
Opioid Signalling 75 1.67e-01 -0.092400 3.02e-01
HSF1-dependent transactivation 32 3.69e-01 -0.091800 5.47e-01
Signaling by Hippo 20 4.78e-01 -0.091700 6.54e-01
Cell-extracellular matrix interactions 16 5.26e-01 -0.091600 6.96e-01
Insulin receptor recycling 21 4.71e-01 0.090900 6.51e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 77 1.71e-01 0.090300 3.08e-01
RNA polymerase II transcribes snRNA genes 71 1.89e-01 0.090200 3.33e-01
STING mediated induction of host immune responses 12 5.89e-01 -0.090200 7.41e-01
HDACs deacetylate histones 30 3.95e-01 0.089800 5.77e-01
ADP signalling through P2Y purinoceptor 12 17 5.22e-01 0.089800 6.93e-01
Extra-nuclear estrogen signaling 65 2.15e-01 -0.088900 3.67e-01
Early Phase of HIV Life Cycle 13 5.80e-01 0.088600 7.36e-01
eNOS activation 11 6.13e-01 -0.088100 7.56e-01
Interaction between L1 and Ankyrins 23 4.64e-01 -0.088100 6.45e-01
G alpha (12/13) signalling events 73 1.99e-01 -0.087100 3.47e-01
Biological oxidations 143 7.41e-02 0.086700 1.61e-01
Signaling by ERBB2 45 3.16e-01 -0.086500 4.88e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 5.27e-01 0.086200 6.96e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.88e-01 0.085700 5.68e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 4.46e-01 0.084700 6.28e-01
Cell surface interactions at the vascular wall 110 1.28e-01 -0.084200 2.42e-01
Acyl chain remodelling of PS 17 5.49e-01 -0.083900 7.13e-01
Metal ion SLC transporters 23 4.87e-01 0.083700 6.63e-01
Organelle biogenesis and maintenance 242 2.54e-02 0.083700 6.98e-02
Repression of WNT target genes 12 6.16e-01 -0.083600 7.60e-01
Regulation of innate immune responses to cytosolic DNA 11 6.34e-01 0.083000 7.77e-01
Hemostasis 491 1.76e-03 -0.083000 7.90e-03
Acyl chain remodelling of PG 14 5.91e-01 -0.083000 7.41e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 4.91e-01 -0.082900 6.65e-01
Regulation of TP53 Activity through Methylation 14 5.92e-01 -0.082800 7.41e-01
Post-translational protein phosphorylation 74 2.21e-01 -0.082400 3.75e-01
Metabolism 1673 4.57e-08 0.082200 4.87e-07
YAP1- and WWTR1 (TAZ)-stimulated gene expression 13 6.09e-01 -0.082000 7.53e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 5.83e-01 0.082000 7.36e-01
Defective B3GAT3 causes JDSSDHD 18 5.48e-01 -0.081800 7.12e-01
Class I peroxisomal membrane protein import 19 5.38e-01 0.081600 7.03e-01
Glucagon-type ligand receptors 20 5.32e-01 0.080800 7.00e-01
Chondroitin sulfate/dermatan sulfate metabolism 44 3.55e-01 0.080600 5.32e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 55 3.02e-01 -0.080500 4.72e-01
Defects in vitamin and cofactor metabolism 20 5.34e-01 -0.080400 7.02e-01
Interleukin-15 signaling 14 6.05e-01 -0.080000 7.50e-01
The NLRP3 inflammasome 14 6.05e-01 0.079800 7.51e-01
Aquaporin-mediated transport 37 4.04e-01 0.079300 5.87e-01
G beta:gamma signalling through PLC beta 16 5.83e-01 0.079200 7.36e-01
Class I MHC mediated antigen processing & presentation 327 1.42e-02 0.079200 4.35e-02
TRAF6 mediated IRF7 activation 15 5.97e-01 -0.079000 7.45e-01
RHO GTPase Effectors 230 4.07e-02 0.078600 1.02e-01
PIP3 activates AKT signaling 238 3.84e-02 0.078200 9.75e-02
Fc epsilon receptor (FCERI) signaling 124 1.35e-01 0.077800 2.53e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 6.71e-01 0.077700 8.11e-01
Signaling by FGFR4 30 4.62e-01 -0.077600 6.44e-01
Vitamin B5 (pantothenate) metabolism 15 6.03e-01 -0.077600 7.50e-01
PI3K/AKT Signaling in Cancer 84 2.22e-01 -0.077200 3.76e-01
G alpha (s) signalling events 96 1.94e-01 -0.076900 3.39e-01
CD28 dependent Vav1 pathway 12 6.45e-01 -0.076800 7.84e-01
Acyl chain remodelling of PE 20 5.56e-01 0.076100 7.18e-01
MET activates RAS signaling 10 6.77e-01 -0.076100 8.13e-01
Toll Like Receptor 4 (TLR4) Cascade 117 1.56e-01 -0.076100 2.87e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 18 5.79e-01 -0.075600 7.35e-01
Cell death signalling via NRAGE, NRIF and NADE 70 2.77e-01 -0.075200 4.41e-01
Protein folding 88 2.24e-01 0.075000 3.78e-01
RHO GTPases Activate WASPs and WAVEs 35 4.44e-01 -0.074900 6.26e-01
SUMOylation 150 1.15e-01 0.074700 2.26e-01
MAP kinase activation 60 3.22e-01 -0.074000 4.94e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 4.56e-01 0.073900 6.38e-01
Signal amplification 28 4.99e-01 0.073800 6.73e-01
SUMOylation of immune response proteins 11 6.72e-01 -0.073800 8.11e-01
Growth hormone receptor signaling 22 5.50e-01 0.073600 7.13e-01
Lysine catabolism 11 6.76e-01 0.072800 8.13e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 4.77e-01 0.072700 6.54e-01
ADORA2B mediated anti-inflammatory cytokines production 72 2.90e-01 -0.072300 4.57e-01
The citric acid (TCA) cycle and respiratory electron transport 149 1.29e-01 0.072100 2.45e-01
MET receptor recycling 10 6.95e-01 -0.071600 8.21e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 6.44e-01 0.071400 7.83e-01
Visual phototransduction 70 3.05e-01 -0.071000 4.75e-01
Signaling by Receptor Tyrosine Kinases 433 1.22e-02 -0.070600 3.88e-02
Free fatty acids regulate insulin secretion 11 6.86e-01 -0.070400 8.16e-01
N-Glycan antennae elongation 13 6.61e-01 0.070400 7.99e-01
Signaling by EGFR in Cancer 20 5.88e-01 -0.069900 7.41e-01
Synthesis of PIPs at the Golgi membrane 15 6.39e-01 -0.069900 7.79e-01
Phospholipid metabolism 181 1.08e-01 -0.069400 2.15e-01
RNA Polymerase II Transcription Termination 61 3.51e-01 0.069200 5.26e-01
Disorders of developmental biology 11 6.92e-01 -0.069000 8.19e-01
Loss of function of MECP2 in Rett syndrome 11 6.92e-01 -0.069000 8.19e-01
Pervasive developmental disorders 11 6.92e-01 -0.069000 8.19e-01
RHO GTPases Activate ROCKs 19 6.06e-01 -0.068400 7.51e-01
Association of TriC/CCT with target proteins during biosynthesis 38 4.66e-01 0.068300 6.46e-01
Thrombin signalling through proteinase activated receptors (PARs) 28 5.34e-01 0.067900 7.02e-01
SUMO E3 ligases SUMOylate target proteins 144 1.60e-01 0.067900 2.93e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 6.97e-01 0.067900 8.22e-01
alpha-linolenic acid (ALA) metabolism 11 6.97e-01 0.067900 8.22e-01
Adherens junctions interactions 20 6.00e-01 -0.067800 7.48e-01
PKA activation 16 6.39e-01 0.067700 7.79e-01
MET activates RAP1 and RAC1 11 6.97e-01 0.067700 8.22e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 5.92e-01 -0.067600 7.41e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 5.47e-02 0.067400 1.28e-01
Nuclear signaling by ERBB4 27 5.48e-01 0.066800 7.12e-01
Glutathione synthesis and recycling 11 7.02e-01 0.066700 8.23e-01
Acetylcholine regulates insulin secretion 10 7.17e-01 -0.066300 8.35e-01
Transcriptional Regulation by VENTX 36 4.93e-01 0.066000 6.67e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 6.51e-01 0.065400 7.89e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 169 1.44e-01 0.065300 2.67e-01
NGF-stimulated transcription 34 5.12e-01 -0.065000 6.84e-01
Interleukin-12 family signaling 51 4.25e-01 0.064600 6.07e-01
NF-kB is activated and signals survival 11 7.12e-01 0.064300 8.33e-01
Golgi Associated Vesicle Biogenesis 53 4.19e-01 0.064300 6.01e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.77e-01 0.064200 6.54e-01
RNA Polymerase III Transcription 41 4.77e-01 0.064200 6.54e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 18 6.37e-01 -0.064200 7.79e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 7.13e-01 -0.064000 8.33e-01
L1CAM interactions 89 2.97e-01 -0.064000 4.67e-01
Inositol phosphate metabolism 42 4.74e-01 -0.063900 6.52e-01
RNA Polymerase III Transcription Initiation 36 5.11e-01 0.063300 6.84e-01
Synthesis of bile acids and bile salts 22 6.08e-01 0.063200 7.52e-01
B-WICH complex positively regulates rRNA expression 32 5.37e-01 0.063100 7.03e-01
Infection with Mycobacterium tuberculosis 25 5.90e-01 0.062200 7.41e-01
Synthesis of very long-chain fatty acyl-CoAs 15 6.78e-01 -0.062000 8.13e-01
Cellular Senescence 121 2.40e-01 0.061900 3.97e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 32 5.46e-01 0.061600 7.11e-01
O-linked glycosylation 80 3.41e-01 -0.061600 5.18e-01
Regulation of TP53 Activity through Association with Co-factors 13 7.01e-01 -0.061500 8.23e-01
Carboxyterminal post-translational modifications of tubulin 28 5.76e-01 0.061100 7.34e-01
Synthesis of PA 28 5.78e-01 -0.060800 7.34e-01
Dissolution of Fibrin Clot 11 7.27e-01 -0.060800 8.42e-01
Role of LAT2/NTAL/LAB on calcium mobilization 15 6.84e-01 0.060700 8.16e-01
Metabolism of Angiotensinogen to Angiotensins 13 7.06e-01 -0.060400 8.27e-01
Regulation of TP53 Degradation 32 5.55e-01 0.060300 7.18e-01
RAF-independent MAPK1/3 activation 22 6.26e-01 -0.060100 7.70e-01
Innate Immune System 812 4.05e-03 0.060000 1.62e-02
Disease 1197 6.03e-04 0.059900 3.01e-03
GPCR ligand binding 235 1.18e-01 -0.059400 2.30e-01
RAB geranylgeranylation 55 4.47e-01 -0.059300 6.29e-01
Establishment of Sister Chromatid Cohesion 10 7.45e-01 0.059300 8.56e-01
GRB2 events in EGFR signaling 10 7.46e-01 -0.059100 8.56e-01
CD28 dependent PI3K/Akt signaling 21 6.40e-01 -0.059000 7.79e-01
Cellular response to heat stress 87 3.46e-01 0.058600 5.21e-01
rRNA modification in the nucleus and cytosol 53 4.62e-01 -0.058400 6.44e-01
Selective autophagy 53 4.69e-01 0.057500 6.49e-01
Potential therapeutics for SARS 35 5.57e-01 0.057400 7.18e-01
TRAF6 mediated NF-kB activation 21 6.50e-01 -0.057300 7.89e-01
Sema3A PAK dependent Axon repulsion 16 6.94e-01 -0.056700 8.21e-01
Response to elevated platelet cytosolic Ca2+ 112 3.09e-01 -0.055800 4.79e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 7.49e-01 -0.055700 8.56e-01
Cargo recognition for clathrin-mediated endocytosis 88 3.68e-01 0.055600 5.46e-01
Interleukin-12 signaling 43 5.29e-01 0.055500 6.98e-01
Glycogen storage diseases 11 7.51e-01 0.055400 8.56e-01
Metalloprotease DUBs 18 6.86e-01 0.055100 8.16e-01
Negative regulation of FGFR1 signaling 20 6.74e-01 0.054400 8.12e-01
Signal Transduction 1884 1.52e-04 -0.054200 8.78e-04
Chemokine receptors bind chemokines 43 5.39e-01 -0.054100 7.04e-01
Regulation of IFNG signaling 14 7.27e-01 -0.054000 8.42e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 7.00e-01 -0.054000 8.23e-01
SLC transporter disorders 76 4.17e-01 0.053900 6.00e-01
Signaling by PDGFR in disease 20 6.79e-01 -0.053500 8.13e-01
Pre-NOTCH Transcription and Translation 32 6.03e-01 -0.053100 7.50e-01
Diseases associated with glycosaminoglycan metabolism 35 5.87e-01 -0.053000 7.41e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 34 5.93e-01 -0.053000 7.42e-01
Regulation of TP53 Expression and Degradation 33 6.10e-01 0.051300 7.54e-01
GABA receptor activation 41 5.74e-01 -0.050800 7.34e-01
Basigin interactions 22 6.86e-01 0.049800 8.16e-01
Folding of actin by CCT/TriC 10 7.86e-01 -0.049600 8.75e-01
HATs acetylate histones 75 4.59e-01 0.049500 6.41e-01
Misspliced GSK3beta mutants stabilize beta-catenin 14 7.51e-01 -0.049000 8.56e-01
S33 mutants of beta-catenin aren't phosphorylated 14 7.51e-01 -0.049000 8.56e-01
S37 mutants of beta-catenin aren't phosphorylated 14 7.51e-01 -0.049000 8.56e-01
S45 mutants of beta-catenin aren't phosphorylated 14 7.51e-01 -0.049000 8.56e-01
T41 mutants of beta-catenin aren't phosphorylated 14 7.51e-01 -0.049000 8.56e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 7.51e-01 -0.049000 8.56e-01
TBC/RABGAPs 42 5.83e-01 0.049000 7.36e-01
Metabolism of lipids 598 4.29e-02 -0.048900 1.06e-01
RHO GTPases activate CIT 19 7.14e-01 -0.048500 8.34e-01
Transcriptional regulation of pluripotent stem cells 19 7.15e-01 -0.048300 8.34e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 7.54e-01 -0.048300 8.58e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 50 5.56e-01 -0.048100 7.18e-01
Sema4D induced cell migration and growth-cone collapse 20 7.11e-01 -0.047900 8.32e-01
Smooth Muscle Contraction 34 6.30e-01 -0.047700 7.74e-01
Signaling by WNT 238 2.07e-01 0.047600 3.59e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 6.83e-01 -0.047200 8.16e-01
Receptor Mediated Mitophagy 11 7.87e-01 0.047000 8.75e-01
ERK/MAPK targets 22 7.03e-01 0.046900 8.25e-01
Sphingolipid metabolism 68 5.04e-01 0.046900 6.77e-01
Sphingolipid de novo biosynthesis 34 6.36e-01 -0.046900 7.79e-01
AMER1 mutants destabilize the destruction complex 13 7.70e-01 -0.046800 8.65e-01
APC truncation mutants have impaired AXIN binding 13 7.70e-01 -0.046800 8.65e-01
AXIN missense mutants destabilize the destruction complex 13 7.70e-01 -0.046800 8.65e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 7.70e-01 -0.046800 8.65e-01
Truncations of AMER1 destabilize the destruction complex 13 7.70e-01 -0.046800 8.65e-01
truncated APC mutants destabilize the destruction complex 13 7.70e-01 -0.046800 8.65e-01
Acyl chain remodelling of PI 12 7.80e-01 0.046500 8.72e-01
Activation of BAD and translocation to mitochondria 14 7.65e-01 0.046100 8.65e-01
Transcriptional regulation of white adipocyte differentiation 80 4.78e-01 0.045900 6.54e-01
MyD88 cascade initiated on plasma membrane 77 4.89e-01 -0.045700 6.63e-01
Toll Like Receptor 10 (TLR10) Cascade 77 4.89e-01 -0.045700 6.63e-01
Toll Like Receptor 5 (TLR5) Cascade 77 4.89e-01 -0.045700 6.63e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 24 6.99e-01 -0.045600 8.23e-01
Toll-like Receptor Cascades 135 3.61e-01 -0.045600 5.39e-01
TRAF3-dependent IRF activation pathway 13 7.76e-01 -0.045600 8.68e-01
KSRP (KHSRP) binds and destabilizes mRNA 16 7.52e-01 0.045600 8.57e-01
GAB1 signalosome 14 7.68e-01 -0.045500 8.65e-01
G-protein beta:gamma signalling 28 6.78e-01 -0.045300 8.13e-01
Inflammasomes 19 7.33e-01 -0.045200 8.46e-01
Nicotinamide salvaging 14 7.72e-01 0.044700 8.66e-01
Epigenetic regulation of gene expression 84 4.80e-01 0.044700 6.55e-01
Other interleukin signaling 21 7.25e-01 -0.044400 8.42e-01
Glycogen synthesis 12 7.92e-01 -0.044000 8.77e-01
Cytosolic sensors of pathogen-associated DNA 57 5.67e-01 0.043900 7.28e-01
Constitutive Signaling by Overexpressed ERBB2 10 8.11e-01 -0.043700 8.90e-01
Chondroitin sulfate biosynthesis 17 7.56e-01 0.043600 8.58e-01
Signaling by FGFR in disease 51 5.94e-01 -0.043200 7.43e-01
Kinesins 37 6.51e-01 0.043100 7.89e-01
Activation of G protein gated Potassium channels 22 7.28e-01 -0.042900 8.42e-01
G protein gated Potassium channels 22 7.28e-01 -0.042900 8.42e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 22 7.28e-01 -0.042900 8.42e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 6.72e-01 -0.042600 8.11e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 7.00e-01 0.042100 8.23e-01
Signaling by ERBB4 47 6.19e-01 -0.041900 7.63e-01
p75 NTR receptor-mediated signalling 88 4.99e-01 -0.041700 6.73e-01
Adaptive Immune System 626 7.77e-02 0.041700 1.67e-01
p75NTR recruits signalling complexes 11 8.14e-01 -0.041000 8.91e-01
Fcgamma receptor (FCGR) dependent phagocytosis 87 5.16e-01 0.040300 6.88e-01
Chaperonin-mediated protein folding 82 5.29e-01 0.040300 6.98e-01
Transport of bile salts and organic acids, metal ions and amine compounds 63 5.83e-01 -0.040100 7.36e-01
ERBB2 Regulates Cell Motility 13 8.06e-01 -0.039400 8.89e-01
Transport of small molecules 542 1.21e-01 0.039200 2.35e-01
Signaling by Insulin receptor 60 6.03e-01 -0.038900 7.50e-01
Post-translational protein modification 1157 2.87e-02 0.038800 7.73e-02
G beta:gamma signalling through CDC42 16 7.89e-01 0.038600 8.75e-01
Downregulation of ERBB2 signaling 24 7.45e-01 -0.038300 8.56e-01
Presynaptic function of Kainate receptors 17 7.87e-01 0.037900 8.75e-01
Keratan sulfate biosynthesis 21 7.64e-01 -0.037900 8.64e-01
Recycling pathway of L1 27 7.37e-01 0.037400 8.49e-01
Factors involved in megakaryocyte development and platelet production 107 5.06e-01 0.037300 6.79e-01
Vesicle-mediated transport 579 1.32e-01 0.036900 2.49e-01
Pregnenolone biosynthesis 10 8.41e-01 -0.036600 9.08e-01
TCR signaling 105 5.18e-01 0.036600 6.90e-01
mRNA decay by 5' to 3' exoribonuclease 15 8.07e-01 -0.036500 8.89e-01
Signaling by FGFR3 30 7.31e-01 -0.036300 8.46e-01
Retinoid metabolism and transport 33 7.21e-01 -0.035900 8.39e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 8.04e-01 0.035800 8.88e-01
Negative regulation of FGFR3 signaling 19 7.88e-01 0.035600 8.75e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 7.56e-01 0.035300 8.58e-01
Phase I - Functionalization of compounds 66 6.22e-01 0.035100 7.66e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 88 5.76e-01 -0.034500 7.34e-01
Toll Like Receptor 2 (TLR2) Cascade 88 5.76e-01 -0.034500 7.34e-01
Toll Like Receptor TLR1:TLR2 Cascade 88 5.76e-01 -0.034500 7.34e-01
Toll Like Receptor TLR6:TLR2 Cascade 88 5.76e-01 -0.034500 7.34e-01
Amino acids regulate mTORC1 49 6.78e-01 0.034300 8.13e-01
Defects in cobalamin (B12) metabolism 12 8.38e-01 0.034100 9.05e-01
Sema4D in semaphorin signaling 24 7.75e-01 0.033700 8.68e-01
ESR-mediated signaling 143 4.93e-01 -0.033300 6.67e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 8.36e-01 -0.033200 9.04e-01
Signaling by FGFR1 36 7.32e-01 -0.033000 8.46e-01
Intracellular signaling by second messengers 275 3.54e-01 0.032600 5.31e-01
ABC transporters in lipid homeostasis 14 8.35e-01 0.032200 9.03e-01
Synaptic adhesion-like molecules 17 8.19e-01 -0.032100 8.94e-01
Mitochondrial Fatty Acid Beta-Oxidation 31 7.59e-01 0.031800 8.61e-01
TP53 Regulates Metabolic Genes 82 6.27e-01 0.031100 7.71e-01
Signaling by Nuclear Receptors 203 4.49e-01 -0.030900 6.30e-01
Biosynthesis of DHA-derived SPMs 13 8.48e-01 0.030800 9.13e-01
Clathrin-mediated endocytosis 126 5.52e-01 0.030700 7.15e-01
Glycerophospholipid biosynthesis 103 5.98e-01 -0.030100 7.46e-01
Diseases of metabolism 192 4.73e-01 0.030100 6.52e-01
Oxidative Stress Induced Senescence 61 6.85e-01 -0.030000 8.16e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 11 8.63e-01 -0.030000 9.22e-01
Regulation of actin dynamics for phagocytic cup formation 64 6.80e-01 0.029900 8.14e-01
Aflatoxin activation and detoxification 10 8.72e-01 -0.029500 9.27e-01
Interleukin-27 signaling 10 8.76e-01 0.028600 9.28e-01
Peroxisomal lipid metabolism 26 8.02e-01 0.028400 8.86e-01
Gene expression (Transcription) 1114 1.16e-01 0.028300 2.28e-01
Oncogene Induced Senescence 30 7.89e-01 0.028200 8.75e-01
HS-GAG degradation 19 8.32e-01 0.028000 9.03e-01
Membrane Trafficking 547 2.71e-01 0.027800 4.33e-01
Chromatin modifying enzymes 189 5.12e-01 -0.027700 6.84e-01
Chromatin organization 189 5.12e-01 -0.027700 6.84e-01
Citric acid cycle (TCA cycle) 22 8.22e-01 0.027700 8.97e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 8.74e-01 0.027600 9.27e-01
Maturation of nucleoprotein 10 8.80e-01 -0.027500 9.30e-01
Interleukin-4 and Interleukin-13 signaling 99 6.38e-01 -0.027400 7.79e-01
Activation of GABAB receptors 34 7.83e-01 -0.027300 8.73e-01
GABA B receptor activation 34 7.83e-01 -0.027300 8.73e-01
Keratan sulfate/keratin metabolism 26 8.10e-01 0.027300 8.90e-01
RA biosynthesis pathway 15 8.55e-01 0.027200 9.17e-01
Negative regulation of the PI3K/AKT network 93 6.51e-01 -0.027200 7.89e-01
Immune System 1689 7.29e-02 0.026900 1.58e-01
Signal transduction by L1 21 8.31e-01 -0.026900 9.03e-01
DAP12 signaling 27 8.11e-01 -0.026600 8.90e-01
PPARA activates gene expression 110 6.31e-01 0.026600 7.74e-01
Inwardly rectifying K+ channels 25 8.19e-01 -0.026500 8.94e-01
Activation of BH3-only proteins 28 8.11e-01 0.026200 8.90e-01
Ub-specific processing proteases 166 5.66e-01 0.025900 7.28e-01
Processing of Intronless Pre-mRNAs 17 8.54e-01 -0.025800 9.16e-01
Arachidonic acid metabolism 42 7.76e-01 0.025400 8.68e-01
Suppression of phagosomal maturation 11 8.86e-01 -0.025000 9.33e-01
Post-translational modification: synthesis of GPI-anchored proteins 61 7.37e-01 -0.024900 8.49e-01
Reversible hydration of carbon dioxide 10 8.94e-01 0.024300 9.38e-01
Plasma lipoprotein remodeling 21 8.49e-01 -0.024000 9.14e-01
RUNX2 regulates bone development 28 8.26e-01 -0.024000 9.00e-01
Regulation of PTEN gene transcription 58 7.53e-01 0.023900 8.57e-01
ZBP1(DAI) mediated induction of type I IFNs 20 8.53e-01 -0.023900 9.16e-01
Peptide ligand-binding receptors 94 6.92e-01 -0.023700 8.19e-01
AKT phosphorylates targets in the cytosol 14 8.78e-01 0.023700 9.30e-01
tRNA modification in the nucleus and cytosol 38 8.01e-01 0.023700 8.85e-01
Negative regulators of DDX58/IFIH1 signaling 30 8.24e-01 -0.023400 8.99e-01
RNA Polymerase II Transcription 996 2.21e-01 0.023200 3.75e-01
Platelet degranulation 107 6.81e-01 -0.023100 8.14e-01
Signaling by NOTCH3 45 7.89e-01 -0.023100 8.75e-01
Metabolism of fat-soluble vitamins 36 8.16e-01 0.022400 8.93e-01
RIP-mediated NFkB activation via ZBP1 17 8.73e-01 0.022300 9.27e-01
Transport of vitamins, nucleosides, and related molecules 32 8.28e-01 -0.022200 9.00e-01
Signaling by TGFB family members 90 7.16e-01 -0.022200 8.34e-01
IRF3-mediated induction of type I IFN 10 9.03e-01 -0.022200 9.41e-01
Amyloid fiber formation 38 8.13e-01 0.022200 8.91e-01
Metabolism of cofactors 18 8.72e-01 0.022000 9.27e-01
Regulation of localization of FOXO transcription factors 11 9.00e-01 0.021800 9.40e-01
activated TAK1 mediates p38 MAPK activation 18 8.74e-01 -0.021600 9.27e-01
Negative regulation of FGFR2 signaling 21 8.64e-01 -0.021600 9.22e-01
Signaling by FGFR 66 7.64e-01 0.021400 8.64e-01
Signaling by FGFR2 55 7.84e-01 0.021300 8.74e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 7.38e-01 -0.020900 8.50e-01
Interleukin-20 family signaling 16 8.85e-01 -0.020800 9.33e-01
Cytochrome P450 - arranged by substrate type 34 8.34e-01 -0.020800 9.03e-01
Axon guidance 453 4.66e-01 0.020100 6.46e-01
Generic Transcription Pathway 881 3.19e-01 0.020000 4.91e-01
Fatty acid metabolism 138 6.87e-01 -0.019900 8.16e-01
Frs2-mediated activation 11 9.10e-01 -0.019800 9.46e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 28 8.59e-01 -0.019400 9.20e-01
NR1H2 and NR1H3-mediated signaling 40 8.32e-01 -0.019400 9.03e-01
DAP12 interactions 32 8.52e-01 0.019000 9.16e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 34 8.53e-01 0.018300 9.16e-01
Signaling by Interleukins 386 5.42e-01 0.018200 7.07e-01
Regulation of lipid metabolism by PPARalpha 112 7.41e-01 0.018100 8.53e-01
Signaling by Non-Receptor Tyrosine Kinases 50 8.34e-01 -0.017200 9.03e-01
Signaling by PTK6 50 8.34e-01 -0.017200 9.03e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 26 8.80e-01 0.017100 9.30e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 9.19e-01 0.016900 9.51e-01
Metabolism of water-soluble vitamins and cofactors 110 7.60e-01 0.016900 8.61e-01
Attenuation phase 22 8.93e-01 0.016600 9.38e-01
p75NTR signals via NF-kB 14 9.16e-01 0.016400 9.51e-01
Deubiquitination 240 6.72e-01 0.015900 8.11e-01
Prolactin receptor signaling 14 9.18e-01 0.015900 9.51e-01
Signaling by FGFR2 in disease 31 8.80e-01 0.015700 9.30e-01
RUNX2 regulates osteoblast differentiation 22 9.01e-01 0.015300 9.40e-01
Intra-Golgi traffic 41 8.66e-01 0.015200 9.22e-01
Diseases of signal transduction by growth factor receptors and second messengers 340 6.38e-01 -0.014900 7.79e-01
VEGFR2 mediated vascular permeability 27 8.94e-01 0.014900 9.38e-01
Response of Mtb to phagocytosis 21 9.07e-01 0.014800 9.43e-01
RAB GEFs exchange GTP for GDP on RABs 86 8.13e-01 -0.014800 8.91e-01
Miscellaneous transport and binding events 20 9.10e-01 0.014600 9.46e-01
MAPK family signaling cascades 273 6.81e-01 -0.014500 8.14e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 8.91e-01 -0.014200 9.37e-01
Synthesis of PC 25 9.03e-01 0.014100 9.41e-01
mRNA 3'-end processing 52 8.61e-01 0.014000 9.21e-01
Nuclear Events (kinase and transcription factor activation) 56 8.58e-01 -0.013900 9.19e-01
TGF-beta receptor signaling activates SMADs 29 8.98e-01 -0.013800 9.39e-01
Signaling by NTRKs 123 7.93e-01 -0.013800 8.77e-01
Cytokine Signaling in Immune system 716 5.35e-01 0.013700 7.03e-01
Signaling by TGF-beta Receptor Complex 68 8.46e-01 -0.013600 9.13e-01
G-protein activation 18 9.21e-01 -0.013400 9.53e-01
Metabolism of vitamins and cofactors 163 7.69e-01 0.013400 8.65e-01
E3 ubiquitin ligases ubiquitinate target proteins 39 8.86e-01 0.013300 9.33e-01
FCGR3A-mediated phagocytosis 62 8.65e-01 0.012500 9.22e-01
Leishmania phagocytosis 62 8.65e-01 0.012500 9.22e-01
Parasite infection 62 8.65e-01 0.012500 9.22e-01
Negative regulation of MAPK pathway 41 8.91e-01 -0.012300 9.37e-01
Signaling by NTRK1 (TRKA) 106 8.27e-01 -0.012300 9.00e-01
Downregulation of ERBB2:ERBB3 signaling 11 9.44e-01 -0.012200 9.69e-01
Leishmania infection 187 7.75e-01 -0.012200 8.68e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 9.17e-01 -0.012100 9.51e-01
Beta-catenin phosphorylation cascade 16 9.34e-01 0.012000 9.63e-01
PRC2 methylates histones and DNA 14 9.39e-01 0.011900 9.65e-01
TNFs bind their physiological receptors 26 9.19e-01 -0.011500 9.51e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 9.39e-01 -0.011400 9.65e-01
BBSome-mediated cargo-targeting to cilium 20 9.36e-01 0.010400 9.64e-01
Surfactant metabolism 16 9.43e-01 0.010400 9.69e-01
Peroxisomal protein import 55 8.95e-01 -0.010300 9.38e-01
Synthesis of IP3 and IP4 in the cytosol 23 9.37e-01 -0.009570 9.65e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 84 8.81e-01 -0.009470 9.30e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.29e-01 0.008620 9.59e-01
EPH-Ephrin signaling 85 8.99e-01 0.007960 9.39e-01
Pre-NOTCH Expression and Processing 47 9.31e-01 0.007270 9.61e-01
Anti-inflammatory response favouring Leishmania parasite infection 109 8.99e-01 -0.007060 9.39e-01
Leishmania parasite growth and survival 109 8.99e-01 -0.007060 9.39e-01
Trafficking of GluR2-containing AMPA receptors 13 9.67e-01 -0.006660 9.88e-01
Nervous system development 473 8.08e-01 0.006550 8.90e-01
G beta:gamma signalling through PI3Kgamma 21 9.60e-01 0.006350 9.82e-01
Downregulation of TGF-beta receptor signaling 24 9.58e-01 -0.006280 9.81e-01
Signaling by PDGFRA extracellular domain mutants 12 9.70e-01 -0.006170 9.88e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 9.70e-01 -0.006170 9.88e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 9.56e-01 0.006020 9.80e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 9.76e-01 0.005510 9.88e-01
TICAM1-dependent activation of IRF3/IRF7 10 9.76e-01 -0.005470 9.88e-01
SHC1 events in EGFR signaling 11 9.76e-01 -0.005310 9.88e-01
Rab regulation of trafficking 118 9.26e-01 -0.004980 9.57e-01
Diseases associated with the TLR signaling cascade 22 9.73e-01 -0.004220 9.88e-01
Diseases of Immune System 22 9.73e-01 -0.004220 9.88e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 9.77e-01 0.004150 9.88e-01
Toll Like Receptor 9 (TLR9) Cascade 88 9.54e-01 0.003590 9.78e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 9.84e-01 -0.003150 9.91e-01
Defective EXT2 causes exostoses 2 13 9.84e-01 -0.003150 9.91e-01
Uptake and function of anthrax toxins 11 9.86e-01 -0.003020 9.91e-01
Deadenylation-dependent mRNA decay 54 9.71e-01 0.002840 9.88e-01
Estrogen-dependent gene expression 82 9.69e-01 0.002520 9.88e-01
PKA-mediated phosphorylation of CREB 18 9.86e-01 0.002350 9.91e-01
MyD88 dependent cascade initiated on endosome 85 9.72e-01 0.002210 9.88e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 85 9.72e-01 0.002210 9.88e-01
EPHB-mediated forward signaling 34 9.84e-01 -0.002050 9.91e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 9.88e-01 0.001970 9.91e-01
FLT3 Signaling 247 9.60e-01 -0.001880 9.82e-01
O-linked glycosylation of mucins 41 9.84e-01 0.001790 9.91e-01
Diseases of glycosylation 119 9.75e-01 0.001690 9.88e-01
Negative regulation of FGFR4 signaling 20 9.90e-01 0.001610 9.93e-01
Adenylate cyclase inhibitory pathway 12 9.94e-01 0.001270 9.96e-01
Signaling by Rho GTPases 352 9.74e-01 -0.001010 9.88e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 15 9.95e-01 0.000947 9.96e-01
MAPK1/MAPK3 signaling 238 9.81e-01 -0.000895 9.91e-01
RAF/MAP kinase cascade 233 9.86e-01 -0.000654 9.91e-01
Developmental Biology 735 9.81e-01 0.000515 9.91e-01
Metabolism of steroid hormones 23 9.97e-01 0.000456 9.98e-01
Activation of kainate receptors upon glutamate binding 25 9.99e-01 0.000118 9.99e-01


Detailed Gene set reports



Classical antibody-mediated complement activation

Classical antibody-mediated complement activation
187
set Classical antibody-mediated complement activation
setSize 10
pANOVA 8.95e-07
s.dist 0.897
p.adjustANOVA 7.94e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHG1 7422.5
IGHG2 7422.5
IGHG3 7422.5
IGHG4 7422.5
C1QB 7347.0
C1QC 7300.0
C1QA 7293.0
IGKC 6958.0
C1R 5320.0
C1S 3261.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHG1 7422.5
IGHG2 7422.5
IGHG3 7422.5
IGHG4 7422.5
C1QB 7347.0
C1QC 7300.0
C1QA 7293.0
IGKC 6958.0
C1R 5320.0
C1S 3261.0


Unwinding of DNA

Unwinding of DNA
1293
set Unwinding of DNA
setSize 12
pANOVA 2.19e-07
s.dist 0.864
p.adjustANOVA 2.12e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178
MCM5 6947
CDC45 6929
MCM2 6923
GINS2 6839
MCM7 6737
MCM3 6575
MCM6 6457
MCM4 6434
GINS4 5968
GINS1 5842
GINS3 4980

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178
MCM5 6947
CDC45 6929
MCM2 6923
GINS2 6839
MCM7 6737
MCM3 6575
MCM6 6457
MCM4 6434
GINS4 5968
GINS1 5842
GINS3 4980


DNA strand elongation

DNA strand elongation
241
set DNA strand elongation
setSize 32
pANOVA 8.38e-15
s.dist 0.792
p.adjustANOVA 3.99e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178
POLD2 7039
RFC4 6973
MCM5 6947
CDC45 6929
MCM2 6923
GINS2 6839
MCM7 6737
FEN1 6643
MCM3 6575
POLD1 6458
MCM6 6457
MCM4 6434
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
GINS4 5968
PRIM2 5909
GINS1 5842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178
POLD2 7039
RFC4 6973
MCM5 6947
CDC45 6929
MCM2 6923
GINS2 6839
MCM7 6737
FEN1 6643
MCM3 6575
POLD1 6458
MCM6 6457
MCM4 6434
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
GINS4 5968
PRIM2 5909
GINS1 5842
RFC1 5836
POLA2 5798
LIG1 5643
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
GINS3 4980
POLD3 4260
DNA2 4061
RPA3 2818


Leading Strand Synthesis

Leading Strand Synthesis
589
set Leading Strand Synthesis
setSize 14
pANOVA 3.28e-07
s.dist 0.788
p.adjustANOVA 3.04e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
PRIM2 5909
RFC1 5836
POLA2 5798
POLA1 5641
POLD4 5405
PRIM1 5297
POLD3 4260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
PRIM2 5909
RFC1 5836
POLA2 5798
POLA1 5641
POLD4 5405
PRIM1 5297
POLD3 4260


Polymerase switching

Polymerase switching
826
set Polymerase switching
setSize 14
pANOVA 3.28e-07
s.dist 0.788
p.adjustANOVA 3.04e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
PRIM2 5909
RFC1 5836
POLA2 5798
POLA1 5641
POLD4 5405
PRIM1 5297
POLD3 4260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
PRIM2 5909
RFC1 5836
POLA2 5798
POLA1 5641
POLD4 5405
PRIM1 5297
POLD3 4260


Lagging Strand Synthesis

Lagging Strand Synthesis
585
set Lagging Strand Synthesis
setSize 20
pANOVA 6.91e-09
s.dist 0.748
p.adjustANOVA 8.28e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
FEN1 6643
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
PRIM2 5909
RFC1 5836
POLA2 5798
LIG1 5643
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
POLD3 4260
DNA2 4061
RPA3 2818

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
FEN1 6643
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
PRIM2 5909
RFC1 5836
POLA2 5798
LIG1 5643
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
POLD3 4260
DNA2 4061
RPA3 2818


Processive synthesis on the lagging strand

Processive synthesis on the lagging strand
851
set Processive synthesis on the lagging strand
setSize 15
pANOVA 1.44e-06
s.dist 0.719
p.adjustANOVA 1.22e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
FEN1 6643
POLD1 6458
PCNA 6148
PRIM2 5909
POLA2 5798
LIG1 5643
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
POLD3 4260
DNA2 4061
RPA3 2818

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
FEN1 6643
POLD1 6458
PCNA 6148
PRIM2 5909
POLA2 5798
LIG1 5643
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
POLD3 4260
DNA2 4061
RPA3 2818


Removal of the Flap Intermediate

Removal of the Flap Intermediate
984
set Removal of the Flap Intermediate
setSize 14
pANOVA 3.42e-06
s.dist 0.717
p.adjustANOVA 2.67e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
FEN1 6643
POLD1 6458
PCNA 6148
PRIM2 5909
POLA2 5798
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
POLD3 4260
DNA2 4061
RPA3 2818

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
FEN1 6643
POLD1 6458
PCNA 6148
PRIM2 5909
POLA2 5798
POLA1 5641
RPA2 5472
RPA1 5468
POLD4 5405
PRIM1 5297
POLD3 4260
DNA2 4061
RPA3 2818


GP1b-IX-V activation signalling

GP1b-IX-V activation signalling
423
set GP1b-IX-V activation signalling
setSize 10
pANOVA 8.82e-05
s.dist -0.716
p.adjustANOVA 0.00053



Top enriched genes

Top 20 genes
GeneID Gene Rank
GP1BA -6384
GP5 -6333
GP1BB -6220
VWF -6077
FLNA -4952
PIK3R1 -4770
YWHAZ -4410
GP9 -3657
RAF1 -1243
SRC -1231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA -6384
GP5 -6333
GP1BB -6220
VWF -6077
FLNA -4952
PIK3R1 -4770
YWHAZ -4410
GP9 -3657
RAF1 -1243
SRC -1231


Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
653
set Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
setSize 14
pANOVA 6.5e-06
s.dist 0.696
p.adjustANOVA 4.86e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
EXO1 6779
MLH1 6552
POLD1 6458
PCNA 6148
LIG1 5643
MSH2 5556
RPA2 5472
RPA1 5468
POLD4 5405
PMS2 5391
POLD3 4260
RPA3 2818
MSH6 1403

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
EXO1 6779
MLH1 6552
POLD1 6458
PCNA 6148
LIG1 5643
MSH2 5556
RPA2 5472
RPA1 5468
POLD4 5405
PMS2 5391
POLD3 4260
RPA3 2818
MSH6 1403


Inhibition of replication initiation of damaged DNA by RB1/E2F1

Inhibition of replication initiation of damaged DNA by RB1/E2F1
522
set Inhibition of replication initiation of damaged DNA by RB1/E2F1
setSize 12
pANOVA 6.44e-05
s.dist 0.666
p.adjustANOVA 0.000401



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFDP1 6832.5
E2F1 6762.0
PRIM2 5909.0
POLA2 5798.0
POLA1 5641.0
RB1 5624.0
PPP2R1B 5366.0
PRIM1 5297.0
PPP2CA 5144.0
PPP2R1A 3746.0
TFDP2 2830.0
PPP2CB 2333.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFDP1 6832.5
E2F1 6762.0
PRIM2 5909.0
POLA2 5798.0
POLA1 5641.0
RB1 5624.0
PPP2R1B 5366.0
PRIM1 5297.0
PPP2CA 5144.0
PPP2R1A 3746.0
TFDP2 2830.0
PPP2CB 2333.0


PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair
770
set PCNA-Dependent Long Patch Base Excision Repair
setSize 21
pANOVA 1.27e-07
s.dist 0.666
p.adjustANOVA 1.25e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
FEN1 6643
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
LIG1 5643
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
APEX1 5079
POLE 4566
POLD3 4260
POLE2 4043
RPA3 2818
POLE4 627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
FEN1 6643
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
LIG1 5643
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
APEX1 5079
POLE 4566
POLD3 4260
POLE2 4043
RPA3 2818
POLE4 627
POLB 466


Mucopolysaccharidoses

Mucopolysaccharidoses
675
set Mucopolysaccharidoses
setSize 11
pANOVA 0.000185
s.dist 0.651
p.adjustANOVA 0.00103



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARSB 7133
GALNS 7123
NAGLU 7055
GUSB 6932
HGSNAT 6239
GNS 5969
HYAL1 5878
GLB1 5250
SGSH 2612
IDUA 1528
IDS -716

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARSB 7133
GALNS 7123
NAGLU 7055
GUSB 6932
HGSNAT 6239
GNS 5969
HYAL1 5878
GLB1 5250
SGSH 2612
IDUA 1528
IDS -716


G1/S-Specific Transcription

G1/S-Specific Transcription
414
set G1/S-Specific Transcription
setSize 27
pANOVA 8.57e-09
s.dist 0.64
p.adjustANOVA 1.01e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC45 6929.0
TFDP1 6832.5
E2F1 6762.0
DHFR 6646.5
TYMS 6626.0
E2F4 6510.0
PCNA 6148.0
CDT1 6076.0
FBXO5 6039.0
LIN9 5977.0
RBBP4 5940.0
CDK1 5789.0
POLA1 5641.0
RBL1 5626.0
CCNE1 5452.0
E2F6 5211.0
RRM2 5130.0
CDC6 4883.0
ORC1 4772.0
TK1 4635.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC45 6929.0
TFDP1 6832.5
E2F1 6762.0
DHFR 6646.5
TYMS 6626.0
E2F4 6510.0
PCNA 6148.0
CDT1 6076.0
FBXO5 6039.0
LIN9 5977.0
RBBP4 5940.0
CDK1 5789.0
POLA1 5641.0
RBL1 5626.0
CCNE1 5452.0
E2F6 5211.0
RRM2 5130.0
CDC6 4883.0
ORC1 4772.0
TK1 4635.0
LIN52 4178.0
CDC25A 3946.0
LIN37 3342.0
LIN54 3131.0
TFDP2 2830.0
RBL2 480.0
E2F5 -2714.0


Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
652
set Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
setSize 14
pANOVA 4.47e-05
s.dist 0.63
p.adjustANOVA 0.000288



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
EXO1 6779
MLH1 6552
POLD1 6458
PCNA 6148
LIG1 5643
MSH2 5556
RPA2 5472
RPA1 5468
POLD4 5405
PMS2 5391
POLD3 4260
RPA3 2818
MSH3 -5036

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
EXO1 6779
MLH1 6552
POLD1 6458
PCNA 6148
LIG1 5643
MSH2 5556
RPA2 5472
RPA1 5468
POLD4 5405
PMS2 5391
POLD3 4260
RPA3 2818
MSH3 -5036


cGMP effects

cGMP effects
1322
set cGMP effects
setSize 13
pANOVA 0.000103
s.dist -0.622
p.adjustANOVA 0.000614



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDE1B -6388
PDE5A -6347
MRVI1 -6251
PDE11A -6149
KCNMB4 -5806
KCNMA1 -5649
ITPR1 -4704
PDE10A -4326
PRKG1 -3947
PDE1A -1372
PDE2A -1143
PDE9A -685
KCNMB1 2434

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDE1B -6388
PDE5A -6347
MRVI1 -6251
PDE11A -6149
KCNMB4 -5806
KCNMA1 -5649
ITPR1 -4704
PDE10A -4326
PRKG1 -3947
PDE1A -1372
PDE2A -1143
PDE9A -685
KCNMB1 2434


Activation of the pre-replicative complex

Activation of the pre-replicative complex
51
set Activation of the pre-replicative complex
setSize 32
pANOVA 1.53e-09
s.dist 0.617
p.adjustANOVA 2.03e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178
MCM5 6947
CDC45 6929
MCM2 6923
MCM7 6737
ORC6 6610
MCM3 6575
MCM6 6457
MCM4 6434
CDT1 6076
PRIM2 5909
ORC5 5901
POLA2 5798
POLA1 5641
GMNN 5599
POLE3 5578
RPA2 5472
ORC2 5470
RPA1 5468
PRIM1 5297

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178
MCM5 6947
CDC45 6929
MCM2 6923
MCM7 6737
ORC6 6610
MCM3 6575
MCM6 6457
MCM4 6434
CDT1 6076
PRIM2 5909
ORC5 5901
POLA2 5798
POLA1 5641
GMNN 5599
POLE3 5578
RPA2 5472
ORC2 5470
RPA1 5468
PRIM1 5297
MCM10 4915
CDC6 4883
ORC1 4772
POLE 4566
POLE2 4043
DBF4 4002
RPA3 2818
CDK2 2038
CDC7 1614
POLE4 627
ORC3 -659
ORC4 -4389


Assembly of the pre-replicative complex

Assembly of the pre-replicative complex
88
set Assembly of the pre-replicative complex
setSize 62
pANOVA 2.22e-16
s.dist 0.603
p.adjustANOVA 1.88e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
ORC5 5901.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
GMNN 5599.0
PSMD7 5518.0
PSMB1 5502.0
ORC2 5470.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
CDC6 4883.0
PSME3 4784.0
ORC1 4772.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
E2F2 3550.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
E2F3 1031.0
PSMB11 -85.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
ORC4 -4389.0
PSME4 -4823.0


Digestion

Digestion
277
set Digestion
setSize 13
pANOVA 0.000176
s.dist -0.601
p.adjustANOVA 0.000987



Top enriched genes

Top 20 genes
GeneID Gene Rank
AMY1A -6470
AMY1B -6470
AMY2A -6470
AMY2B -6470
CEL -5624
PNLIP -5576
PNLIPRP2 -5483
PNLIPRP1 -4894
CLPS -4337
GUCY2C -4206
MGAM 159
LCT 1146
PIR 6278

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AMY1A -6470
AMY1B -6470
AMY2A -6470
AMY2B -6470
CEL -5624
PNLIP -5576
PNLIPRP2 -5483
PNLIPRP1 -4894
CLPS -4337
GUCY2C -4206
MGAM 159
LCT 1146
PIR 6278


Mismatch Repair

Mismatch Repair
651
set Mismatch Repair
setSize 15
pANOVA 6.24e-05
s.dist 0.597
p.adjustANOVA 0.000393



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
EXO1 6779
MLH1 6552
POLD1 6458
PCNA 6148
LIG1 5643
MSH2 5556
RPA2 5472
RPA1 5468
POLD4 5405
PMS2 5391
POLD3 4260
RPA3 2818
MSH6 1403
MSH3 -5036

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
EXO1 6779
MLH1 6552
POLD1 6458
PCNA 6148
LIG1 5643
MSH2 5556
RPA2 5472
RPA1 5468
POLD4 5405
PMS2 5391
POLD3 4260
RPA3 2818
MSH6 1403
MSH3 -5036


DNA Replication Pre-Initiation

DNA Replication Pre-Initiation
240
set DNA Replication Pre-Initiation
setSize 78
pANOVA 8.06e-20
s.dist 0.597
p.adjustANOVA 7.79e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
CDC45 6929.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
CDC45 6929.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PRIM2 5909.0
ORC5 5901.0
PSMC3 5838.0
PSMD5 5799.0
POLA2 5798.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
POLA1 5641.0
PSMB5 5639.0
PSME1 5611.0
GMNN 5599.0
POLE3 5578.0
PSMD7 5518.0
PSMB1 5502.0
RPA2 5472.0
ORC2 5470.0
RPA1 5468.0
PSMB4 5442.0
PSMB7 5383.0
PRIM1 5297.0
PSMD3 5255.0
PSMB2 4941.0
MCM10 4915.0
CDC6 4883.0
PSME3 4784.0
ORC1 4772.0
PSMD4 4621.0
POLE 4566.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
POLE2 4043.0
RPS27A 4035.0
DBF4 4002.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
E2F2 3550.0
RPA3 2818.0
CDK2 2038.0
PSMA4 1889.0
PSMC5 1819.0
CDC7 1614.0
UBC 1069.0
E2F3 1031.0
POLE4 627.0
PSMB11 -85.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
ORC4 -4389.0
PSME4 -4823.0


Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
988
set Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize 24
pANOVA 4.29e-07
s.dist 0.596
p.adjustANOVA 3.87e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
FEN1 6643
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
LIG1 5643
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
APEX1 5079
POLE 4566
POLD3 4260
POLE2 4043
PARP2 3913
PARP1 3085

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
FEN1 6643
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
LIG1 5643
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
APEX1 5079
POLE 4566
POLD3 4260
POLE2 4043
PARP2 3913
PARP1 3085
RPA3 2818
POLE4 627
POLB 466
PARG -3385


E2F mediated regulation of DNA replication

E2F mediated regulation of DNA replication
313
set E2F mediated regulation of DNA replication
setSize 21
pANOVA 2.57e-06
s.dist 0.593
p.adjustANOVA 2.07e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178.0
TFDP1 6832.5
E2F1 6762.0
ORC6 6610.0
PRIM2 5909.0
ORC5 5901.0
POLA2 5798.0
CDK1 5789.0
POLA1 5641.0
RB1 5624.0
ORC2 5470.0
PPP2R1B 5366.0
PRIM1 5297.0
PPP2CA 5144.0
ORC1 4772.0
CCNB1 4474.0
PPP2R1A 3746.0
TFDP2 2830.0
PPP2CB 2333.0
ORC3 -659.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
TFDP1 6832.5
E2F1 6762.0
ORC6 6610.0
PRIM2 5909.0
ORC5 5901.0
POLA2 5798.0
CDK1 5789.0
POLA1 5641.0
RB1 5624.0
ORC2 5470.0
PPP2R1B 5366.0
PRIM1 5297.0
PPP2CA 5144.0
ORC1 4772.0
CCNB1 4474.0
PPP2R1A 3746.0
TFDP2 2830.0
PPP2CB 2333.0
ORC3 -659.0
ORC4 -4389.0


Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
1289
set Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize 46
pANOVA 5.17e-12
s.dist 0.588
p.adjustANOVA 1.13e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
CHEK2 5204.0
PSMB2 4941.0
CHEK1 4868.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
CDC25A 3946.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
PSME4 -4823.0


p53-Independent DNA Damage Response

p53-Independent DNA Damage Response
1336
set p53-Independent DNA Damage Response
setSize 46
pANOVA 5.17e-12
s.dist 0.588
p.adjustANOVA 1.13e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
CHEK2 5204.0
PSMB2 4941.0
CHEK1 4868.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
CDC25A 3946.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
PSME4 -4823.0


p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint
1337
set p53-Independent G1/S DNA damage checkpoint
setSize 46
pANOVA 5.17e-12
s.dist 0.588
p.adjustANOVA 1.13e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
CHEK2 5204.0
PSMB2 4941.0
CHEK1 4868.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
CDC25A 3946.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
PSME4 -4823.0


Polo-like kinase mediated events

Polo-like kinase mediated events
825
set Polo-like kinase mediated events
setSize 16
pANOVA 4.78e-05
s.dist 0.587
p.adjustANOVA 0.000305



Top enriched genes

Top 20 genes
GeneID Gene Rank
WEE1 6933
MYBL2 6338
FOXM1 6274
PLK1 6083
LIN9 5977
RBBP4 5940
CCNB2 5485
CDC25C 4996
CCNB1 4474
PKMYT1 4425
LIN52 4178
CDC25A 3946
LIN37 3342
LIN54 3131
CENPF 2965
EP300 -1616

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WEE1 6933
MYBL2 6338
FOXM1 6274
PLK1 6083
LIN9 5977
RBBP4 5940
CCNB2 5485
CDC25C 4996
CCNB1 4474
PKMYT1 4425
LIN52 4178
CDC25A 3946
LIN37 3342
LIN54 3131
CENPF 2965
EP300 -1616


Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER
434
set Gap-filling DNA repair synthesis and ligation in GG-NER
setSize 23
pANOVA 1.14e-06
s.dist 0.586
p.adjustANOVA 9.78e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
LIG1 5643
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
POLE 4566
XRCC1 4542
POLD3 4260
POLE2 4043
RPS27A 4035
RPA3 2818
UBC 1069

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLD1 6458
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
LIG1 5643
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
POLE 4566
XRCC1 4542
POLD3 4260
POLE2 4043
RPS27A 4035
RPA3 2818
UBC 1069
POLE4 627
POLK 345
LIG3 -388


CDT1 association with the CDC6:ORC:origin complex

CDT1 association with the CDC6:ORC:origin complex
124
set CDT1 association with the CDC6:ORC:origin complex
setSize 53
pANOVA 3.93e-13
s.dist 0.576
p.adjustANOVA 1.18e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
ORC6 6610.0
PSMD8 6460.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
ORC5 5901.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
ORC6 6610.0
PSMD8 6460.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
ORC5 5901.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
GMNN 5599.0
PSMD7 5518.0
PSMB1 5502.0
ORC2 5470.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
CDC6 4883.0
PSME3 4784.0
ORC1 4772.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
ORC4 -4389.0
PSME4 -4823.0


Orc1 removal from chromatin

Orc1 removal from chromatin
762
set Orc1 removal from chromatin
setSize 64
pANOVA 1.82e-15
s.dist 0.575
p.adjustANOVA 1.02e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
ORC5 5901.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
ORC2 5470.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
CDC6 4883.0
SKP2 4825.0
PSME3 4784.0
ORC1 4772.0
CCNA2 4710.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
CUL1 2962.0
RBX1 2770.0
CDK2 2038.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
SKP1 -3504.0
ORC4 -4389.0
PSME4 -4823.0


Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)
981
set Regulation of ornithine decarboxylase (ODC)
setSize 46
pANOVA 1.71e-11
s.dist 0.573
p.adjustANOVA 3.35e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
ODC1 5310.0
PSMD3 5255.0
OAZ1 5109.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
NQO1 3842.0
PSMA4 1889.0
PSMC5 1819.0
OAZ2 262.0
AZIN1 -80.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
PSME4 -4823.0


Termination of translesion DNA synthesis

Termination of translesion DNA synthesis
1215
set Termination of translesion DNA synthesis
setSize 29
pANOVA 1.41e-07
s.dist 0.565
p.adjustANOVA 1.38e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLI 6943
POLD1 6458
ISG15 6381
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
POLH 5633
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
USP10 4778
UBE2L6 4648
POLE 4566
UBA7 4514
POLD3 4260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 7039
RFC4 6973
POLI 6943
POLD1 6458
ISG15 6381
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
POLH 5633
POLE3 5578
RPA2 5472
RPA1 5468
POLD4 5405
USP10 4778
UBE2L6 4648
POLE 4566
UBA7 4514
POLD3 4260
POLE2 4043
RPS27A 4035
RPA3 2818
UBC 1069
POLE4 627
TRIM25 525
POLK 345
USP43 -313
REV1 -423


SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1
1016
set SCF-beta-TrCP mediated degradation of Emi1
setSize 49
pANOVA 8.21e-12
s.dist 0.564
p.adjustANOVA 1.68e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
CDC20 6303.0
FBXO5 6039.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
CDC20 6303.0
FBXO5 6039.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
FZR1 4422.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
BTRC 3345.0
CUL1 2962.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
SKP1 -3504.0
PSME4 -4823.0


Synthesis of DNA

Synthesis of DNA
1154
set Synthesis of DNA
setSize 113
pANOVA 5.01e-25
s.dist 0.562
p.adjustANOVA 8.48e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178
PSMD1 7122
PSMA6 7097
POLD2 7039
RFC4 6973
MCM5 6947
CDC45 6929
MCM2 6923
PSMC2 6899
PSMA7 6889
GINS2 6839
PSMD10 6749
MCM7 6737
PSMA8 6688
FEN1 6643
ORC6 6610
MCM3 6575
PSMD8 6460
POLD1 6458
MCM6 6457

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
POLD2 7039.0
RFC4 6973.0
MCM5 6947.0
CDC45 6929.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
GINS2 6839.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
FEN1 6643.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
POLD1 6458.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
RFC5 6313.0
RFC3 6208.0
PCNA 6148.0
RFC2 6095.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
GINS4 5968.0
PSMB6 5911.0
PRIM2 5909.0
ORC5 5901.0
CDC23 5891.0
GINS1 5842.0
PSMC3 5838.0
RFC1 5836.0
PSMD5 5799.0
POLA2 5798.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
LIG1 5643.0
POLA1 5641.0
PSMB5 5639.0
PSME1 5611.0
UBE2S 5594.0
POLE3 5578.0
PSMD7 5518.0
PSMB1 5502.0
RPA2 5472.0
ORC2 5470.0
RPA1 5468.0
CCNE1 5452.0
PSMB4 5442.0
POLD4 5405.0
PSMB7 5383.0
PRIM1 5297.0
PSMD3 5255.0
UBE2C 5251.0
GINS3 4980.0
PSMB2 4941.0
CDC6 4883.0
SKP2 4825.0
PSME3 4784.0
ORC1 4772.0
CCNA2 4710.0
PSMD4 4621.0
POLE 4566.0
PSMB8 4442.0
FZR1 4422.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
POLD3 4260.0
ANAPC5 4103.0
PSMD14 4074.0
ANAPC2 4070.0
DNA2 4061.0
POLE2 4043.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
CCNE2 3846.0
ANAPC15 3737.0
ANAPC7 3688.0
ANAPC16 3279.0
CUL1 2962.0
RPA3 2818.0
RBX1 2770.0
CDC26 2741.0
ANAPC11 2585.0
CDK2 2038.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
ANAPC10 766.0
POLE4 627.0
PSMB11 -85.0
CDC16 -309.0
UBE2E1 -495.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
ANAPC1 -741.0
CDC27 -1147.0
ANAPC4 -1308.0
UBE2D1 -3192.0
SKP1 -3504.0
ORC4 -4389.0
PSME4 -4823.0


Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
1240
set Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
setSize 15
pANOVA 0.000163
s.dist 0.562
p.adjustANOVA 0.00092



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFDP1 6832.5
E2F1 6762.0
E2F4 6510.0
MYBL2 6338.0
LIN9 5977.0
RBBP4 5940.0
CDK1 5789.0
RBL1 5626.0
CCNA2 4710.0
LIN52 4178.0
LIN37 3342.0
LIN54 3131.0
TFDP2 2830.0
RBL2 480.0
E2F5 -2714.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFDP1 6832.5
E2F1 6762.0
E2F4 6510.0
MYBL2 6338.0
LIN9 5977.0
RBBP4 5940.0
CDK1 5789.0
RBL1 5626.0
CCNA2 4710.0
LIN52 4178.0
LIN37 3342.0
LIN54 3131.0
TFDP2 2830.0
RBL2 480.0
E2F5 -2714.0


Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)
216
set Cross-presentation of soluble exogenous antigens (endosomes)
setSize 46
pANOVA 4.29e-11
s.dist 0.562
p.adjustANOVA 7.35e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
FCGR1A 7171.5
FCGR1B 7171.5
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FCGR1A 7171.5
FCGR1B 7171.5
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
MRC1 5063.5
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
CD207 -3744.0
PSME4 -4823.0
MRC2 -4899.0


Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D
1290
set Ubiquitin-dependent degradation of Cyclin D
setSize 46
pANOVA 4.54e-11
s.dist 0.561
p.adjustANOVA 7.67e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
CDK4 6159.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
CDK4 6159.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
CCND1 2954.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
GSK3B -3677.0
PSME4 -4823.0


DNA Replication

DNA Replication
239
set DNA Replication
setSize 120
pANOVA 3.58e-26
s.dist 0.559
p.adjustANOVA 9.68e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM8 7178
PSMD1 7122
PSMA6 7097
POLD2 7039
RFC4 6973
MCM5 6947
CDC45 6929
MCM2 6923
PSMC2 6899
PSMA7 6889
GINS2 6839
E2F1 6762
PSMD10 6749
MCM7 6737
PSMA8 6688
FEN1 6643
ORC6 6610
MCM3 6575
PSMD8 6460
POLD1 6458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
POLD2 7039.0
RFC4 6973.0
MCM5 6947.0
CDC45 6929.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
GINS2 6839.0
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
PSMA8 6688.0
FEN1 6643.0
ORC6 6610.0
MCM3 6575.0
PSMD8 6460.0
POLD1 6458.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
RFC5 6313.0
RFC3 6208.0
PCNA 6148.0
RFC2 6095.0
CDT1 6076.0
PSMD9 6000.5
PSMB9 5986.0
GINS4 5968.0
PSMB6 5911.0
PRIM2 5909.0
ORC5 5901.0
CDC23 5891.0
GINS1 5842.0
PSMC3 5838.0
RFC1 5836.0
PSMD5 5799.0
POLA2 5798.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
LIG1 5643.0
POLA1 5641.0
PSMB5 5639.0
PSME1 5611.0
GMNN 5599.0
UBE2S 5594.0
POLE3 5578.0
PSMD7 5518.0
PSMB1 5502.0
RPA2 5472.0
ORC2 5470.0
RPA1 5468.0
CCNE1 5452.0
PSMB4 5442.0
POLD4 5405.0
PSMB7 5383.0
PRIM1 5297.0
PSMD3 5255.0
UBE2C 5251.0
GINS3 4980.0
PSMB2 4941.0
MCM10 4915.0
CDC6 4883.0
SKP2 4825.0
PSME3 4784.0
ORC1 4772.0
CCNA2 4710.0
PSMD4 4621.0
POLE 4566.0
PSMB8 4442.0
FZR1 4422.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
POLD3 4260.0
ANAPC5 4103.0
PSMD14 4074.0
ANAPC2 4070.0
DNA2 4061.0
POLE2 4043.0
RPS27A 4035.0
DBF4 4002.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
CCNE2 3846.0
ANAPC15 3737.0
ANAPC7 3688.0
E2F2 3550.0
ANAPC16 3279.0
CUL1 2962.0
RPA3 2818.0
RBX1 2770.0
CDC26 2741.0
ANAPC11 2585.0
CDK2 2038.0
PSMA4 1889.0
PSMC5 1819.0
CDC7 1614.0
UBC 1069.0
E2F3 1031.0
ANAPC10 766.0
POLE4 627.0
PSMB11 -85.0
CDC16 -309.0
UBE2E1 -495.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
ANAPC1 -741.0
CDC27 -1147.0
ANAPC4 -1308.0
UBE2D1 -3192.0
SKP1 -3504.0
ORC4 -4389.0
PSME4 -4823.0


Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation
967
set Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize 44
pANOVA 1.39e-10
s.dist 0.559
p.adjustANOVA 2.21e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
PAK2 -3904.0
PSME4 -4823.0


Peptide chain elongation

Peptide chain elongation
801
set Peptide chain elongation
setSize 56
pANOVA 4.98e-13
s.dist 0.558
p.adjustANOVA 1.41e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL11 7288
RPS27L 7208
RPS12 7041
RPL31 6916
RPL28 6883
RPL32 6829
RPL5 6738
RPL19 6267
RPS20 6165
RPL23A 6151
RPL34 6085
RPS11 6080
RPS9 6036
RPL26 5868
RPL36A 5811
RPL18 5751
RPL3 5549
RPL37 5368
RPL7 5283
RPL10 5245

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL11 7288
RPS27L 7208
RPS12 7041
RPL31 6916
RPL28 6883
RPL32 6829
RPL5 6738
RPL19 6267
RPS20 6165
RPL23A 6151
RPL34 6085
RPS11 6080
RPS9 6036
RPL26 5868
RPL36A 5811
RPL18 5751
RPL3 5549
RPL37 5368
RPL7 5283
RPL10 5245
RPL4 5178
RPL8 5146
RPS15A 5077
RPL38 5009
RPL18A 5007
RPS26 5006
RPS5 4924
RPS29 4870
RPL23 4837
RPS8 4815
RPS6 4715
RPL35A 4524
EEF1A1 4515
RPS18 4509
RPS23 4434
RPS27 4325
RPS3 4216
RPL30 4078
RPS21 4049
RPS27A 4035
RPLP2 3975
FAU 3920
EEF2 3897
RPS19 3399
RPS15 3358
RPL22 3353
RPS24 3243
RPS4X 3121
RPS16 3078
RPL14 2328
RPL15 1936
RPL37A 1622
RPS14 578
RPS13 -1324
RPL22L1 -4747
RPL3L -6450


Metabolism of polyamines

Metabolism of polyamines
639
set Metabolism of polyamines
setSize 52
pANOVA 4.6e-12
s.dist 0.554
p.adjustANOVA 1.11e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
AMD1 7348.0
PAOX 7339.0
PSMD1 7122.0
PSMA6 7097.0
SRM 7096.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AMD1 7348.0
PAOX 7339.0
PSMD1 7122.0
PSMA6 7097.0
SRM 7096.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
ODC1 5310.0
PSMD3 5255.0
OAZ1 5109.0
SMOX 4975.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
NQO1 3842.0
PSMA4 1889.0
PSMC5 1819.0
OAZ2 262.0
AZIN1 -80.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
SAT1 -1969.0
PSME4 -4823.0
SMS -5006.0


Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere
269
set Deposition of new CENPA-containing nucleosomes at the centromere
setSize 25
pANOVA 1.63e-06
s.dist 0.554
p.adjustANOVA 1.34e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CENPM 7004
MIS18A 6739
CENPN 6445
CENPO 6418
STRA13 6144
CENPI 5987
RBBP4 5940
H2AFX 5906
RUVBL1 5767
CENPT 5223
CENPP 5101
HJURP 5059
RBBP7 4972
MIS18BP1 4479
CENPA 4454
CENPH 4309
CENPC 4273
OIP5 4271
CENPK 3990
CENPL 3389

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CENPM 7004
MIS18A 6739
CENPN 6445
CENPO 6418
STRA13 6144
CENPI 5987
RBBP4 5940
H2AFX 5906
RUVBL1 5767
CENPT 5223
CENPP 5101
HJURP 5059
RBBP7 4972
MIS18BP1 4479
CENPA 4454
CENPH 4309
CENPC 4273
OIP5 4271
CENPK 3990
CENPL 3389
SMARCA5 2926
CENPQ 2748
CENPW 2248
ITGB3BP 14
RSF1 -5782


Nucleosome assembly

Nucleosome assembly
750
set Nucleosome assembly
setSize 25
pANOVA 1.63e-06
s.dist 0.554
p.adjustANOVA 1.34e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CENPM 7004
MIS18A 6739
CENPN 6445
CENPO 6418
STRA13 6144
CENPI 5987
RBBP4 5940
H2AFX 5906
RUVBL1 5767
CENPT 5223
CENPP 5101
HJURP 5059
RBBP7 4972
MIS18BP1 4479
CENPA 4454
CENPH 4309
CENPC 4273
OIP5 4271
CENPK 3990
CENPL 3389

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CENPM 7004
MIS18A 6739
CENPN 6445
CENPO 6418
STRA13 6144
CENPI 5987
RBBP4 5940
H2AFX 5906
RUVBL1 5767
CENPT 5223
CENPP 5101
HJURP 5059
RBBP7 4972
MIS18BP1 4479
CENPA 4454
CENPH 4309
CENPC 4273
OIP5 4271
CENPK 3990
CENPL 3389
SMARCA5 2926
CENPQ 2748
CENPW 2248
ITGB3BP 14
RSF1 -5782


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
388
set Formation of a pool of free 40S subunits
setSize 66
pANOVA 8.09e-15
s.dist 0.553
p.adjustANOVA 3.99e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL11 7288
RPS27L 7208
RPS12 7041
RPL31 6916
RPL28 6883
RPL32 6829
EIF3F 6768
EIF3L 6753
RPL5 6738
RPL19 6267
EIF3H 6190
RPS20 6165
RPL23A 6151
RPL34 6085
RPS11 6080
RPS9 6036
RPL26 5868
RPL36A 5811
RPL18 5751
EIF3D 5666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL11 7288.0
RPS27L 7208.0
RPS12 7041.0
RPL31 6916.0
RPL28 6883.0
RPL32 6829.0
EIF3F 6768.0
EIF3L 6753.0
RPL5 6738.0
RPL19 6267.0
EIF3H 6190.0
RPS20 6165.0
RPL23A 6151.0
RPL34 6085.0
RPS11 6080.0
RPS9 6036.0
RPL26 5868.0
RPL36A 5811.0
RPL18 5751.0
EIF3D 5666.0
EIF3K 5638.0
RPL3 5549.0
RPL37 5368.0
RPL7 5283.0
RPL10 5245.0
RPL4 5178.0
RPL8 5146.0
RPS15A 5077.0
EIF3B 5029.0
RPL38 5009.0
RPL18A 5007.0
RPS26 5006.0
EIF3I 4995.0
RPS5 4924.0
RPS29 4870.0
RPL23 4837.0
RPS8 4815.0
RPS6 4715.0
RPL35A 4524.0
RPS18 4509.0
RPS23 4434.0
EIF3G 4428.0
RPS27 4325.0
RPS3 4216.0
RPL30 4078.0
RPS21 4049.0
RPS27A 4035.0
RPLP2 3975.0
FAU 3920.0
RPS19 3399.0
RPS15 3358.0
RPL22 3353.0
RPS24 3243.0
EIF3M 3170.0
RPS4X 3121.0
RPS16 3078.0
EIF3C 2708.5
RPL14 2328.0
RPL15 1936.0
EIF3E 1770.0
RPL37A 1622.0
RPS14 578.0
RPS13 -1324.0
EIF3A -3972.0
RPL22L1 -4747.0
RPL3L -6450.0


Translesion Synthesis by POLH

Translesion Synthesis by POLH
1262
set Translesion Synthesis by POLH
setSize 16
pANOVA 0.000134
s.dist 0.551
p.adjustANOVA 0.000784



Top enriched genes

Top 20 genes
GeneID Gene Rank
RFC4 6973
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
POLH 5633
RPA2 5472
RPA1 5468
NPLOC4 5233
RPS27A 4035
UFD1L 3036
RPA3 2818
UBC 1069
SPRTN 629
RCHY1 -2065

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RFC4 6973
RFC5 6313
RFC3 6208
PCNA 6148
RFC2 6095
RFC1 5836
POLH 5633
RPA2 5472
RPA1 5468
NPLOC4 5233
RPS27A 4035
UFD1L 3036
RPA3 2818
UBC 1069
SPRTN 629
RCHY1 -2065


Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G
1302
set Vif-mediated degradation of APOBEC3G
setSize 45
pANOVA 1.54e-10
s.dist 0.551
p.adjustANOVA 2.42e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
RBX1 2770.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
CUL5 -4707.0
PSME4 -4823.0


Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1
93
set Autodegradation of the E3 ubiquitin ligase COP1
setSize 46
pANOVA 1.27e-10
s.dist 0.548
p.adjustANOVA 2.05e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
PSMB8 4442.0
PSMD2 4375.0
RFWD2 4369.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
TP53 731.0
PSMB11 -85.0
PSMC6 -602.0
PSMA3 -686.0
ATM -3884.0
PSME4 -4823.0


AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA
21
set AUF1 (hnRNP D0) binds and destabilizes mRNA
setSize 48
pANOVA 5.84e-11
s.dist 0.546
p.adjustANOVA 9.75e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
HSPB1 7011.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMD1 7122.0
PSMA6 7097.0
HSPB1 7011.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
EIF4G1 4561.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
HSPA8 4038.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
PSMB11 -85.0
HNRNPD -176.0
PSMC6 -602.0
PSMA3 -686.0
PSME4 -4823.0
HSPA1A -6269.5


G1/S Transition

G1/S Transition
413
set G1/S Transition
setSize 121
pANOVA 3.86e-25
s.dist 0.545
p.adjustANOVA 7.46e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
CKS1B 7374.0
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
WEE1 6933.0
CDC45 6929.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
TFDP1 6832.5
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
DHFR 6646.5
TYMS 6626.0
ORC6 6610.0
MCM3 6575.0
E2F4 6510.0
PSMD8 6460.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CKS1B 7374.0
MCM8 7178.0
PSMD1 7122.0
PSMA6 7097.0
MCM5 6947.0
WEE1 6933.0
CDC45 6929.0
MCM2 6923.0
PSMC2 6899.0
PSMA7 6889.0
TFDP1 6832.5
E2F1 6762.0
PSMD10 6749.0
MCM7 6737.0
DHFR 6646.5
TYMS 6626.0
ORC6 6610.0
MCM3 6575.0
E2F4 6510.0
PSMD8 6460.0
MCM6 6457.0
MCM4 6434.0
PSMF1 6427.0
CDK4 6159.0
PCNA 6148.0
CDT1 6076.0
FBXO5 6039.0
PSMD9 6000.5
PSMB9 5986.0
LIN9 5977.0
RBBP4 5940.0
PSMB6 5911.0
PRIM2 5909.0
ORC5 5901.0
PSMC3 5838.0
PSMD5 5799.0
POLA2 5798.0
CDK1 5789.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
POLA1 5641.0
PSMB5 5639.0
RBL1 5626.0
RB1 5624.0
PSME1 5611.0
GMNN 5599.0
POLE3 5578.0
PSMD7 5518.0
PSMB1 5502.0
RPA2 5472.0
ORC2 5470.0
RPA1 5468.0
CCNE1 5452.0
PSMB4 5442.0
PSMB7 5383.0
PPP2R1B 5366.0
PRIM1 5297.0
PSMD3 5255.0
E2F6 5211.0
PPP2CA 5144.0
MYC 5136.0
RRM2 5130.0
PSMB2 4941.0
MCM10 4915.0
CDC6 4883.0
SKP2 4825.0
PSME3 4784.0
ORC1 4772.0
CCNA2 4710.0
TK1 4635.0
PSMD4 4621.0
POLE 4566.0
CCNB1 4474.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
LIN52 4178.0
PSMD14 4074.0
POLE2 4043.0
RPS27A 4035.0
DBF4 4002.0
CDC25A 3946.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
CCNE2 3846.0
AKT1 3759.0
PPP2R1A 3746.0
CCNH 3354.0
LIN37 3342.0
LIN54 3131.0
AKT2 3096.0
CUL1 2962.0
CCND1 2954.0
TFDP2 2830.0
RPA3 2818.0
PPP2CB 2333.0
CDK2 2038.0
PSMA4 1889.0
PSMC5 1819.0
CDC7 1614.0
CABLES1 1150.0
UBC 1069.0
POLE4 627.0
RBL2 480.0
MAX 195.0
PSMC6 -602.0
ORC3 -659.0
PSMA3 -686.0
CDK7 -915.0
CDKN1A -1333.0
PTK6 -1682.0
E2F5 -2714.0
SKP1 -3504.0
MNAT1 -3894.0
ORC4 -4389.0
AKT3 -4622.0
CDKN1B -5373.0


The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint
1220
set The role of GTSE1 in G2/M progression after G2 checkpoint
setSize 54
pANOVA 5.05e-12
s.dist 0.543
p.adjustANOVA 1.13e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
FKBPL 7327.0
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PLK1 6083.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
CDK1 5789.0
GTSE1 5788.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FKBPL 7327.0
PSMD1 7122.0
PSMA6 7097.0
PSMC2 6899.0
PSMA7 6889.0
PSMD10 6749.0
PSMA8 6688.0
PSMD8 6460.0
PSMF1 6427.0
PLK1 6083.0
PSMD9 6000.5
PSMB9 5986.0
PSMB6 5911.0
PSMC3 5838.0
PSMD5 5799.0
CDK1 5789.0
GTSE1 5788.0
PSMC1 5766.0
PSMA1 5745.0
PSMD12 5723.0
PSMC4 5658.0
PSMB5 5639.0
PSME1 5611.0
PSMD7 5518.0
PSMB1 5502.0
CCNB2 5485.0
PSMB4 5442.0
PSMB7 5383.0
PSMD3 5255.0
PSMB2 4941.0
PSME3 4784.0
PSMD4 4621.0
CCNB1 4474.0
PSMB8 4442.0
PSMD2 4375.0
PSMD11 4362.0
PSMD13 4315.0
PSMD14 4074.0
RPS27A 4035.0
PSME2 3938.0
PSMB10 3891.0
PSMD6 3889.0
PSMA4 1889.0
PSMC5 1819.0
UBC 1069.0
TP53 731.0
MAPRE1 664.0
PSMB11 -85.0
PSMC6 -602.0
HSP90AA1 -660.0
PSMA3 -686.0
HSP90AB1 -888.0
CDKN1A -1333.0
PSME4 -4823.0


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] fgsea_1.14.0                gplots_3.0.3               
##  [9] DESeq2_1.28.1               SummarizedExperiment_1.18.1
## [11] DelayedArray_0.14.0         matrixStats_0.56.0         
## [13] Biobase_2.48.0              GenomicRanges_1.40.0       
## [15] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [17] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [19] reshape2_1.4.4              forcats_0.5.0              
## [21] stringr_1.4.0               dplyr_1.0.0                
## [23] purrr_0.3.4                 readr_1.3.1                
## [25] tidyr_1.1.0                 tibble_3.0.1               
## [27] ggplot2_3.3.2               tidyverse_1.3.0            
## [29] locfit_1.5-9.4              statmod_1.4.34             
## [31] plyr_1.8.6                 
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] MASS_7.3-51.6          scales_1.1.1           hms_0.5.3             
## [49] promises_1.1.1         RColorBrewer_1.1-2     yaml_2.2.1            
## [52] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
## [55] stringi_1.4.6          RSQLite_2.2.0          highr_0.8             
## [58] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
## [61] BiocParallel_1.22.0    rlang_0.4.6            pkgconfig_2.0.3       
## [64] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
## [67] htmlwidgets_1.5.1      bit_1.1-15.2           tidyselect_1.1.0      
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          grid_4.0.2             readxl_1.3.1          
## [85] data.table_1.12.8      blob_1.2.1             reprex_0.3.0          
## [88] digest_0.6.25          pbmcapply_1.5.0        xtable_1.8-4          
## [91] httpuv_1.5.4           munsell_0.5.0

END of report