Source: https://github.com/markziemann/GeneNameErrors2020

View the reports: http://ziemann-lab.net/public/gene_name_errors/

Intro

Gene name errors result when data are imported improperly into MS Excel and other spreadsheet programs (Zeeberg et al, 2004). Certain gene names like MARCH3, SEPT2 and DEC1 are converted into date format. These errors are surprisingly common in supplementary data files in the field of genomics (Ziemann et al, 2016). This could be considered a small error because it only affects a small number of genes, however it is symptomtic of poor data processing methods. The purpose of this script is to identify gene name errors present in supplementary files of PubMed Central articles in the previous month.

library("XML")
library("jsonlite")
library("xml2")
library("reutils")
library("readxl")

Get PMC IDs

Here I will be getting PubMed Central IDs for the previous month.

Start with figuring out the date to search PubMed Central.

CURRENT_MONTH=format(Sys.time(), "%m")
CURRENT_YEAR=format(Sys.time(), "%Y")

if (CURRENT_MONTH == "01") {
  PREV_YEAR=as.character(as.numeric(format(Sys.time(), "%Y"))-1)
  PREV_MONTH="12"
} else {
  PREV_YEAR=CURRENT_YEAR
  PREV_MONTH=as.character(as.numeric(format(Sys.time(), "%m"))-1)
}

DATE=paste(PREV_YEAR,"/",PREV_MONTH,sep="")
DATE
## [1] "2021/10"

Let’s see how many PMC IDs we have in the past month.

QUERY ='((genom*[Abstract]))'

ESEARCH_RES <- esearch(term=QUERY, db = "pmc", rettype = "uilist", retmode = "xml", retstart = 0, 
  retmax = 5000000, usehistory = TRUE, webenv = NULL, querykey = NULL, sort = NULL, field = NULL, 
  datetype = NULL, reldate = NULL, mindate = DATE, maxdate = DATE)

pmc <- efetch(ESEARCH_RES,retmode="text",rettype="uilist",outfile="pmcids.txt")
## Retrieving UIDs 1 to 500
## Retrieving UIDs 501 to 1000
## Retrieving UIDs 1001 to 1500
## Retrieving UIDs 1501 to 2000
## Retrieving UIDs 2001 to 2500
## Retrieving UIDs 2501 to 3000
## Retrieving UIDs 3001 to 3500
pmc <- read.table(pmc)
pmc <- paste("PMC",pmc$V1,sep="")
NUM_ARTICLES=length(pmc)
NUM_ARTICLES
## [1] 3320
writeLines(pmc,con="pmc.txt")

Run the screen

Now run the bash script. Note that false positives can occur (~1.5%) and these results have not been verified by a human.

Here are some definitions:

system("./gene_names.sh pmc.txt")
results <- readLines("results.txt")

XLS <- results[grep("XLS",results,ignore.case=TRUE)]
NUM_XLS = length(XLS)
NUM_XLS
## [1] 4537
NUM_XLS_ARTICLES = length(unique(sapply(strsplit(XLS," "),"[[",1)))
NUM_XLS_ARTICLES
## [1] 803
GENELISTS <- XLS[lapply(strsplit(XLS," "),length)>2]
#GENELISTS

NUM_GENELISTS <- length(unique(sapply(strsplit(GENELISTS," "),"[[",2)))
NUM_GENELISTS
## [1] 579
NUM_GENELIST_ARTICLES <- length(unique(sapply(strsplit(GENELISTS," "),"[[",1)))
NUM_GENELIST_ARTICLES
## [1] 277
ERROR_GENELISTS <- XLS[lapply(strsplit(XLS," "),length)>3]
#ERROR_GENELISTS

NUM_ERROR_GENELISTS = length(ERROR_GENELISTS)
NUM_ERROR_GENELISTS
## [1] 174
GENELIST_ERROR_ARTICLES <- unique(sapply(strsplit(ERROR_GENELISTS," "),"[[",1))
GENELIST_ERROR_ARTICLES
##  [1] "PMC8555832" "PMC8554095" "PMC8519947" "PMC8514428" "PMC8511044"
##  [6] "PMC8544599" "PMC8532573" "PMC8497462" "PMC8479071" "PMC8530322"
## [11] "PMC8498718" "PMC8518179" "PMC8501628" "PMC8523829" "PMC8519440"
## [16] "PMC8490982" "PMC8513875" "PMC8509297" "PMC8507324" "PMC8498966"
## [21] "PMC8498917" "PMC8554124" "PMC8521585" "PMC8514339" "PMC8505442"
## [26] "PMC8496489" "PMC8494907" "PMC8492352" "PMC8486594" "PMC8486213"
## [31] "PMC8458293" "PMC8455625" "PMC8455578" "PMC8529555" "PMC8544335"
## [36] "PMC8539775" "PMC8481544" "PMC8463701" "PMC8518362" "PMC8517214"
## [41] "PMC8528285" "PMC8515723" "PMC8503750" "PMC8494642" "PMC8516354"
## [46] "PMC8505008" "PMC8503558" "PMC8502891" "PMC8494765" "PMC8476631"
## [51] "PMC8455334" "PMC8484507" "PMC8490889" "PMC8490743" "PMC8490713"
## [56] "PMC8490697" "PMC8452624" "PMC8489709" "PMC8488206" "PMC8488120"
## [61] "PMC8449357" "PMC8445938" "PMC8484522" "PMC8482641"
NUM_ERROR_GENELIST_ARTICLES <- length(GENELIST_ERROR_ARTICLES) 
NUM_ERROR_GENELIST_ARTICLES
## [1] 64
ERROR_PROPORTION = NUM_ERROR_GENELIST_ARTICLES / NUM_GENELIST_ARTICLES
ERROR_PROPORTION
## [1] 0.2310469

Look at the errors detected

Here you can have a look at all the gene lists detected in the past month, as well as those with errors. The dates are obvious errors, these are commonly dates in September, March, December and October. The five-digit numbers represent dates as they are encoded in the Excel internal format. The five digit number is the number of days since 1900. If you were to take these numbers and put them into Excel and format the cells as dates, then these will also mostly map to dates in September, March, December and October.

#GENELISTS

ERROR_GENELISTS
##   [1] "PMC8555832 /pmc/articles/PMC8555832/bin/pgen.1009813.s023.xlsx Hsapiens 5 44445 44441 44446 44450 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##   [2] "PMC8554095 /pmc/articles/PMC8554095/bin/Table2.XLSX Hsapiens 10 43894 44085 43892 43893 44080 43900 43901 43896 44086 43898"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##   [3] "PMC8554095 /pmc/articles/PMC8554095/bin/Table2.XLSX Hsapiens 13 43897 44076 44077 43891 44085 43892 43893 44080 44078 43901 43896 43895 43898"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##   [4] "PMC8554095 /pmc/articles/PMC8554095/bin/Table2.XLSX Ggallus 10 44077 43891 44085 43893 44082 43892 43900 43896 44086 43898"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [5] "PMC8554095 /pmc/articles/PMC8554095/bin/Table2.XLSX Hsapiens 1 43532"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##   [6] "PMC8554095 /pmc/articles/PMC8554095/bin/Table2.XLSX Hsapiens 2 43716 43534"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [7] "PMC8519947 /pmc/articles/PMC8519947/bin/41467_2021_26299_MOESM14_ESM.xlsx Hsapiens 17 26148 92973 55747 90834 26222 11217 23285 79686 80761 90784 55410 54094 94023 25787 10896 84849 83935"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##   [8] "PMC8519947 /pmc/articles/PMC8519947/bin/41467_2021_26299_MOESM14_ESM.xlsx Hsapiens 15 92973 54094 26148 25787 79686 55747 90784 55410 90834 94023 80761 23285 84849 83935 10896"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##   [9] "PMC8519947 /pmc/articles/PMC8519947/bin/41467_2021_26299_MOESM14_ESM.xlsx Hsapiens 7 79686 80761 55747 26148 23285 83935 90784"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [10] "PMC8519947 /pmc/articles/PMC8519947/bin/41467_2021_26299_MOESM4_ESM.xlsx Hsapiens 17 26148 92973 55747 90834 26222 11217 23285 79686 80761 90784 55410 54094 94023 25787 10896 84849 83935"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [11] "PMC8519947 /pmc/articles/PMC8519947/bin/41467_2021_26299_MOESM6_ESM.xlsx Hsapiens 15 92973 54094 26148 25787 79686 55747 90784 55410 90834 94023 80761 23285 84849 83935 10896"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [12] "PMC8519947 /pmc/articles/PMC8519947/bin/41467_2021_26299_MOESM8_ESM.xlsx Hsapiens 7 79686 80761 55747 26148 23285 83935 90784"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [13] "PMC8514428 zip/Supplementary_Software_1/Genomics_Analysis/interim_files/df_Out_preGeneRename.xlsx Hsapiens 1 12-SEP"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [14] "PMC8511044 /pmc/articles/PMC8511044/bin/41467_2021_25860_MOESM9_ESM.xlsx Hsapiens 1 42619"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##  [15] "PMC8511044 /pmc/articles/PMC8511044/bin/41467_2021_25860_MOESM9_ESM.xlsx Hsapiens 1 42429"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##  [16] "PMC8544599 /pmc/articles/PMC8544599/bin/Table_1.XLSX Hsapiens 13 44531 44265 44266 44256 44257 44258 44259 44260 44261 44262 44263 44264 44454"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [17] "PMC8532573 /pmc/articles/PMC8532573/bin/13059_2021_2513_MOESM5_ESM.xlsx Hsapiens 27 44444 44442 44256 44443 44266 44257 44449 44265 44446 44261 44257 44262 44264 44441 44447 44451 44531 44445 44259 44440 44258 44256 44260 44263 44450 44453 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [18] "PMC8532573 /pmc/articles/PMC8532573/bin/13059_2021_2513_MOESM7_ESM.xlsx Hsapiens 27 44442 44444 44256 44265 44447 44259 44531 44446 44256 44450 44262 44449 44443 44266 44445 44441 44448 44451 44440 44257 44257 44263 44453 44261 44264 44260 44258"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [19] "PMC8532573 /pmc/articles/PMC8532573/bin/13059_2021_2513_MOESM9_ESM.xlsx Hsapiens 27 44259 44262 44444 44442 44531 44256 44257 44256 44265 44266 44257 44258 44260 44261 44263 44264 44440 44449 44450 44451 44453 44441 44443 44445 44446 44447 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [20] "PMC8497462 /pmc/articles/PMC8497462/bin/42003_2021_2673_MOESM4_ESM.xlsx Hsapiens 1 44259"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [21] "PMC8479071 /pmc/articles/PMC8479071/bin/41467_2021_25935_MOESM13_ESM.xlsx Mmusculus 1 37681"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [22] "PMC8479071 /pmc/articles/PMC8479071/bin/41467_2021_25935_MOESM4_ESM.xlsx Mmusculus 10 37316 40787 38596 39692 38961 38231 37681 40603 37135 39873"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [23] "PMC8479071 /pmc/articles/PMC8479071/bin/41467_2021_25935_MOESM7_ESM.xlsx Hsapiens 63 39326 39326 39326 39326 39326 39326 39326 39326 39326 40603 40603 38777 38777 38777 38961 40787 40787 40787 40787 40787 40787 40787 40787 39508 39508 39508 39508 39508 39508 38412 38412 38412 38412 38412 38047 38047 39142 37500 39692 39692 39692 38596 38596 38596 40057 40057 40057 40057 40057 40057 40057 40057 40057 40057 40057 40057 40057 40057 40057 37316 37681 37681 37681"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [24] "PMC8479071 /pmc/articles/PMC8479071/bin/41467_2021_25935_MOESM8_ESM.xlsx Mmusculus 8 37316 40787 38596 39692 38961 38231 37681 40603"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [25] "PMC8530322 /pmc/articles/PMC8530322/bin/pone.0258316.s002.xlsx Hsapiens 1 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [26] "PMC8498718 /pmc/articles/PMC8498718/bin/mmc1.xlsx Hsapiens 28 43435 43160 43161 43160 43169 43170 43161 43162 43163 43164 43165 43166 43167 43168 43358 43344 43353 43354 43355 43357 43345 43346 43347 43348 43349 43350 43351 43352"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [27] "PMC8518179 /pmc/articles/PMC8518179/bin/13059_2021_2498_MOESM2_ESM.xlsx Mmusculus 1 43535"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##  [28] "PMC8518179 /pmc/articles/PMC8518179/bin/13059_2021_2498_MOESM2_ESM.xlsx Mmusculus 1 43717"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##  [29] "PMC8501628 /pmc/articles/PMC8501628/bin/41021_2021_216_MOESM2_ESM.xlsx Mmusculus 1 42795"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [30] "PMC8523829 /pmc/articles/PMC8523829/bin/DataSheet4.xlsx Hsapiens 1 44258"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [31] "PMC8523829 /pmc/articles/PMC8523829/bin/DataSheet4.xlsx Hsapiens 2 44263 44265"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [32] "PMC8523829 /pmc/articles/PMC8523829/bin/DataSheet4.xlsx Hsapiens 1 44257"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [33] "PMC8523829 /pmc/articles/PMC8523829/bin/DataSheet4.xlsx Hsapiens 1 44258"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [34] "PMC8519440 /pmc/articles/PMC8519440/bin/pntd.0009750.s017.xlsx Hsapiens 26 11951 11758 12281 15323 10721 11453 10021 16180 13800 28723 10899 22725 15324 14221 10378 23893 17177 11469 25485 11721 10295 14821 17631 11956 15645 16496"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [35] "PMC8490982 /pmc/articles/PMC8490982/bin/EMBR-22-e52823-s004.xlsx Hsapiens 4 40057 39692 38961 40787"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [36] "PMC8490982 /pmc/articles/PMC8490982/bin/EMBR-22-e52823-s004.xlsx Hsapiens 4 38231 39326 38961 41153"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [37] "PMC8490982 /pmc/articles/PMC8490982/bin/EMBR-22-e52823-s005.xlsx Hsapiens 2 37135 38596"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##  [38] "PMC8490982 /pmc/articles/PMC8490982/bin/EMBR-22-e52823-s005.xlsx Hsapiens 2 37135 38231"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##  [39] "PMC8490982 /pmc/articles/PMC8490982/bin/EMBR-22-e52823-s005.xlsx Hsapiens 2 40057 37135"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##  [40] "PMC8490982 /pmc/articles/PMC8490982/bin/EMBR-22-e52823-s008.xlsx Hsapiens 2 40057 37500"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##  [41] "PMC8513875 /pmc/articles/PMC8513875/bin/pgen.1009834.s011.xlsx Dmelanogaster 1 38596"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [42] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 4 44441 44440 44443 44444"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
##  [43] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 2 44440 44443"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##  [44] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 3 44440 44441 44444"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [45] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 2 44440 44443"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##  [46] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 3 44440 44441 44444"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [47] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 1 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [48] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_1.XLSX Dmelanogaster 1 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [49] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_2.XLSX Dmelanogaster 1 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [50] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_2.XLSX Dmelanogaster 1 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [51] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_2.XLSX Dmelanogaster 1 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [52] "PMC8509297 /pmc/articles/PMC8509297/bin/Table_2.XLSX Dmelanogaster 1 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [53] "PMC8507324 zip/data_sheet/Supplementary_Table_3.xlsx Hsapiens 1 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [54] "PMC8498966 /pmc/articles/PMC8498966/bin/mmc10.xlsx Hsapiens 41 44083 43894 43893 44083 44085 44166 43894 44083 44166 44076 43891 44083 44080 44075 44083 44166 44085 44083 44085 44166 43894 44083 44083 44085 44083 44083 44166 43894 44082 44075 44085 44083 44166 43891 43894 44080 44083 44166 44083 44166 44085"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [55] "PMC8498917 /pmc/articles/PMC8498917/bin/ADVS-8-2101426-s003.xlsx Hsapiens 12 44447 44450 44446 44441 44257 44454 44448 44445 44449 44260 44256 44261"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [56] "PMC8498917 /pmc/articles/PMC8498917/bin/ADVS-8-2101426-s003.xlsx Hsapiens 12 44261 44445 44447 44260 44449 44448 44446 44256 44454 44450 44257 44441"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [57] "PMC8498917 /pmc/articles/PMC8498917/bin/ADVS-8-2101426-s003.xlsx Hsapiens 12 44448 44447 44441 44450 44261 44449 44446 44445 44260 44454 44256 44257"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [58] "PMC8498917 /pmc/articles/PMC8498917/bin/ADVS-8-2101426-s003.xlsx Hsapiens 9 44445 44260 44441 44261 44447 44446 44450 44448 44454"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [59] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet10.xlsx Mmusculus 1 43165"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [60] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet10.xlsx Mmusculus 5 39695 43166 43170 43347 43894"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [61] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet10.xlsx Mmusculus 1 38596"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [62] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet10.xlsx Mmusculus 16 43348 44085 43891 43165 44081 43167 43347 43166 43352 43345 43346 43353 43354 43350 43170 43168"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [63] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet10.xlsx Mmusculus 28 44085 43894 43348 43891 43347 39695 43170 43166 44081 42618 43163 43167 43901 43893 43354 43169 40971 41156 41162 42620 43352 43353 39697 42621 43345 40969 43346 43350"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [64] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet10.xlsx Mmusculus 3 44085 43348 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [65] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet2.XLSX Hsapiens 1 43527"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [66] "PMC8554124 /pmc/articles/PMC8554124/bin/DataSheet3.XLSX Hsapiens 1 43527"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [67] "PMC8521585 /pmc/articles/PMC8521585/bin/41467_2021_26174_MOESM5_ESM.xlsx Ggallus 1 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [68] "PMC8514339 /pmc/articles/PMC8514339/bin/41586_2021_3922_MOESM2_ESM.xlsx Hsapiens 24 42068 42256 42248 42254 42065 42253 42257 42262 42259 42249 42262 42253 42250 42251 42064 42258 42257 42070 42253 42071 42065 42072 42251 42249"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [69] "PMC8505442 /pmc/articles/PMC8505442/bin/41467_2021_26272_MOESM9_ESM.xlsx Hsapiens 19 43896 44084 43893 44079 44085 43892 44082 44083 43901 43894 43892 43898 44078 43897 44081 44076 43895 44080 44077"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [70] "PMC8505442 /pmc/articles/PMC8505442/bin/41467_2021_26272_MOESM9_ESM.xlsx Hsapiens 19 43896 44084 43893 44079 44085 43892 44082 44083 43901 43894 43892 43898 44078 43897 44081 44076 43895 44080 44077"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [71] "PMC8496489 /pmc/articles/PMC8496489/bin/Table_4.XLSX Hsapiens 15 43898 43899 43899 44075 43900 44083 44083 44083 43892 44079 43896 44082 44082 44081 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [72] "PMC8496489 /pmc/articles/PMC8496489/bin/Table_4.XLSX Hsapiens 19 43892 43898 43899 43899 44075 44083 44083 43892 44076 44079 44085 44085 44085 44085 43896 44082 44082 44081 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [73] "PMC8496489 /pmc/articles/PMC8496489/bin/Table_4.XLSX Hsapiens 13 43892 43898 43899 43899 44083 44083 44083 43892 44079 44079 44085 44082 44081"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [74] "PMC8496489 /pmc/articles/PMC8496489/bin/Table_4.XLSX Hsapiens 16 43891 43899 43899 44075 44083 44083 44083 44083 43892 43894 44079 44079 44079 44082 44082 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##  [75] "PMC8496489 /pmc/articles/PMC8496489/bin/Table_5.XLSX Hsapiens 1 43534"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [76] "PMC8496489 /pmc/articles/PMC8496489/bin/Table_6.XLSX Hsapiens 1 44075"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [77] "PMC8494907 /pmc/articles/PMC8494907/bin/41419_2021_4191_MOESM2_ESM.xlsx Hsapiens 28 38412 37865 39142 39873 36951 37226 38047 40057 40238 38231 37681 39508 37500 39692 38777 38961 38596 40787 36951 37316 37135 39326 42248 37316 41153 40422 41883 40603"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [78] "PMC8494907 /pmc/articles/PMC8494907/bin/41419_2021_4191_MOESM2_ESM.xlsx Hsapiens 28 39142 37865 41883 38412 37500 39692 38047 37316 38961 37681 40603 38231 40422 36951 41153 38777 39873 38596 39508 36951 39326 40787 42248 37226 37316 37135 40057 40238"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [79] "PMC8492352 /pmc/articles/PMC8492352/bin/jciinsight-6-144575-s123.xlsx Mmusculus 361 44089 43892 43895 43896 43897 44076 43898 43892 44082 44084 44081 43899 44077 44078 44085 43891 44080 44083 44075 44083 44076 44085 43898 43896 44082 43897 43892 44084 43891 44077 44081 44078 44089 44080 44075 43897 43891 44083 43891 44075 44080 43894 43893 44077 43892 43897 44084 43898 43896 44082 43895 44085 43892 44078 44081 44076 44089 44083 44085 44075 44078 44089 44076 44081 43892 44084 43896 44082 43895 43898 43899 43891 43897 44083 44085 44080 44075 44075 44080 43893 44077 43896 44084 43898 44082 43895 43892 43891 44083 43892 44081 44078 44076 44085 44089 44075 44080 44077 43896 43898 44084 43895 44082 43892 44083 43891 44078 44076 44085 44089 44075 44080 44077 43898 44084 43896 44082 43892 43892 44078 43891 44076 44089 44075 44085 44084 43898 44078 43896 43891 43897 44089 44076 44089 43892 43895 43898 43894 44081 44085 44084 44076 43896 43891 44079 43900 43899 43891 44080 44075 44089 43898 43899 44085 44083 44080 44081 44075 44080 44077 44083 44081 44076 43892 44089 44085 43891 43895 43892 43897 43896 44084 44079 44082 43898 44078 44075 44081 44075 44085 44083 44080 44076 43895 43892 43892 44089 44084 43897 44082 43896 43898 44078 44078 44089 44076 44084 43894 43893 44082 43896 44077 43892 44081 43895 43891 43892 44085 43897 44083 44080 44075 44078 44089 44076 44081 44082 44084 44085 43892 43898 44079 44077 43897 43891 44083 44080 44075 44075 44085 44080 43892 44083 44082 44089 44081 43893 44077 44084 43898 44078 43897 43891 44076 44075 44085 44089 44081 44082 44077 43898 44084 43895 44078 43891 43897 44076 44089 44081 44082 44076 43891 43892 43892 43898 44084 43901 44077 44078 44085 44083 44080 44075 44089 44078 43895 44083 44089 43892 43891 44081 44076 43892 43897 44077 43898 44078 44080 44075 43895 44083 43891 44078 44080 44075 44083 43891 43898 44077 43896 43897 44082 43895 43892 44089 44078 44085 44080 43892 44081 44075 43897 43899 44077 43898 44084 44082 43896 44078 43892 43895 44083 44076 44081 44080 44085 43892 44075 44089 44075 44085 44080 44079 43893 44077 44084 44078 44082 43897 43896 43892 44083 43891 43892 44076 44089 44075 44080 44081 44083 44077 44082 43897 43896 44084 43898 43892 43891 44078 44089 44076"
##  [80] "PMC8492352 /pmc/articles/PMC8492352/bin/jciinsight-6-144575-s123.xlsx Mmusculus 35 44078 44078 43898 44082 44083 44085 43892 44081 44089 44089 44082 44083 44078 43892 44075 44083 44080 43891 44077 43892 44078 44075 43899 44089 44078 44085 44083 44078 44089 44081 44076 44085 43895 43897 44083"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [81] "PMC8486594 /pmc/articles/PMC8486594/bin/MOL2-15-2766-s002.xlsx Hsapiens 13 43891 43893 43891 43896 43892 43898 43897 43899 43900 43901 43894 43892 43895"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [82] "PMC8486594 /pmc/articles/PMC8486594/bin/MOL2-15-2766-s002.xlsx Hsapiens 2 43891 43892"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##  [83] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Hsapiens 1 43898"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [84] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Hsapiens 1 44079"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [85] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Hsapiens 1 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [86] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Hsapiens 1 44083"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [87] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Ggallus 1 44078"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [88] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Ggallus 1 43892"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [89] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s001.xlsx Ggallus 1 43896"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [90] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s004.xlsx Hsapiens 28 44454 44257 44256 44449 44262 44259 44441 44450 44256 44261 44266 44258 44447 44446 44453 44531 44263 44260 44264 44451 44440 44443 44265 44448 44257 44444 44442 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [91] "PMC8486213 /pmc/articles/PMC8486213/bin/CAS-112-4377-s005.xlsx Hsapiens 27 1-Mar 2-Mar 1-Mar 10-Mar 11-Mar 2-Mar 3-Mar 4-Mar 5-Mar 6-Mar 7-Mar 8-Mar 9-Mar 15-Sep 1-Sep 10-Sep 11-Sep 12-Sep 14-Sep 2-Sep 3-Sep 4-Sep 5-Sep 6-Sep 7-Sep 8-Sep 9-Sep"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [92] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM4_ESM.xlsx Hsapiens 8 42248 39692 38961 40422 40787 37500 39326 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [93] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM5_ESM.xlsx Hsapiens 7 39692 40787 40422 37500 39326 40057 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [94] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM5_ESM.xlsx Hsapiens 8 42248 39692 40787 40422 37500 39326 40057 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [95] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM5_ESM.xlsx Hsapiens 8 42248 39692 40787 40422 37500 39326 40057 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [96] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM5_ESM.xlsx Hsapiens 7 39692 40787 40422 37500 39326 40057 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [97] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM5_ESM.xlsx Hsapiens 2 42248 40422"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [98] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM5_ESM.xlsx Hsapiens 6 39692 40787 37500 39326 40057 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##  [99] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM7_ESM.xlsx Hsapiens 21 43892 44078 43892 44081 44080 43897 44085 43899 43894 43891 43896 44082 43898 44076 43893 44075 44083 44079 43891 44084 43895"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [100] "PMC8458293 /pmc/articles/PMC8458293/bin/41467_2021_25288_MOESM7_ESM.xlsx Hsapiens 21 44078 43898 43892 43891 43895 43893 43894 44076 43899 44081 44080 43892 44084 44079 43897 43896 44085 44082 44075 44083 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [101] "PMC8455625 /pmc/articles/PMC8455625/bin/41525_2021_239_MOESM1_ESM.xlsx Hsapiens 1 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [102] "PMC8455578 /pmc/articles/PMC8455578/bin/41467_2021_25769_MOESM5_ESM.xlsx Hsapiens 20 44446 44258 44453 44265 44265 44265 44441 44258 44446 44446 44446 44447 44266 44260 44441 44448 44256 44448 44446 44453"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [103] "PMC8455578 /pmc/articles/PMC8455578/bin/41467_2021_25769_MOESM5_ESM.xlsx Hsapiens 207 44450 44261 44266 44258 44447 44444 44442 44450 44261 44266 44258 44447 44263 44260 44444 44442 44450 44443 44265 44448 44260 44450 44444 44442 44262 44259 44441 44443 44257 44256 44449 44262 44259 44441 44450 44261 44266 44258 44447 44531 44263 44260 44264 44451 44440 44265 44448 44442 44450 44449 44262 44259 44441 44531 44260 44444 44442 44453 44260 44264 44265 44450 44443 44265 44448 44444 44442 44449 44262 44259 44441 44258 44447 44453 44443 44265 44448 44444 44531 44263 44260 44451 44442 44449 44262 44259 44441 44450 44446 44453 44262 44446 44443 44265 44448 44444 44442 44263 44265 44442 44441 44261 44266 44258 44447 44531 44444 44442 44264 44450 44263 44260 44442 44262 44263 44260 44260 44444 44442 44261 44266 44258 44447 44449 44450 44443 44265 44448 44444 44442 44446 44453 44260 44264 44451 44440 44443 44265 44258 44446 44451 44443 44265 44448 44444 44442 44449 44444 44442 44450 44263 44264 44443 44265 44448 44262 44259 44441 44453 44531 44444 44442 44450 44442 44531 44259 44441 44258 44447 44263 44260 44442 44448 44442 44261 44266 44264 44265 44262 44259 44441 44450 44440 44448 44444 44442 44257 44256 44444 44442 44260 44264 44442 44449 44259 44441 44450 44443 44265 44448 44444 44442 44443 44265 44448 44444 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
## [104] "PMC8529555 /pmc/articles/PMC8529555/bin/mmc11.xlsx Mmusculus 1 2002-03-01"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## [105] "PMC8544335 /pmc/articles/PMC8544335/bin/aging-13-203619-s001.xlsx Hsapiens 1 43898"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [106] "PMC8539775 /pmc/articles/PMC8539775/bin/12885_2021_8818_MOESM2_ESM.xlsx Hsapiens 2 43893 44085"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
## [107] "PMC8481544 /pmc/articles/PMC8481544/bin/41467_2021_25951_MOESM10_ESM.xlsx Hsapiens 4 44449 44442 44443 44447"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [108] "PMC8463701 /pmc/articles/PMC8463701/bin/41467_2021_25893_MOESM5_ESM.xlsx Athaliana 1 44474"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
## [109] "PMC8518362 /pmc/articles/PMC8518362/bin/AJT-21-3133-s003.xlsx Ggallus 34 9. Trégouët DA, Heath S, Saut N, et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: Results from aGWAS approach. Blood. 2009. doi:10.1182/blood-2008-11-190389"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
## [110] "PMC8517214 /pmc/articles/PMC8517214/bin/mmc3.xlsx Hsapiens 1 44166"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [111] "PMC8517214 /pmc/articles/PMC8517214/bin/mmc5.xlsx Hsapiens 1 43892"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [112] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Mmusculus 27 44256 44257 44256 44265 44266 44257 44258 44259 44260 44261 44262 44263 44264 44454 44440 44449 44450 44451 44453 44441 44442 44443 44444 44445 44446 44447 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
## [113] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Mmusculus 27 44256 44257 44256 44265 44266 44257 44258 44259 44260 44261 44262 44263 44264 44454 44440 44449 44450 44451 44453 44441 44442 44443 44444 44445 44446 44447 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
## [114] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Mmusculus 27 44256 44257 44256 44265 44266 44257 44258 44259 44260 44261 44262 44263 44264 44454 44440 44449 44450 44451 44453 44441 44442 44443 44444 44445 44446 44447 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
## [115] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 3 44263 44260 44447"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
## [116] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 1 44256"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
## [117] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Mmusculus 27 44256 44257 44256 44265 44266 44257 44258 44259 44260 44261 44262 44263 44264 44454 44440 44449 44450 44451 44453 44441 44442 44443 44444 44445 44446 44447 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
## [118] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 3 44263 44260 44447"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
## [119] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 5 44263 44262 44261 44258 44265"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [120] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 1 44256"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
## [121] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 5 44263 44262 44261 44258 44265"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [122] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 1 44256"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
## [123] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 19 44257 44449 44450 44454 44264 44263 44262 44261 44260 44259 44258 44257 44440 44441 44444 44442 44448 44446 44447"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [124] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 7 44449 44450 44454 44264 44260 44256 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
## [125] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 3 44263 44260 44447"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
## [126] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 1 44256"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
## [127] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 1 44256"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
## [128] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 19 44257 44449 44450 44454 44264 44263 44262 44261 44260 44259 44258 44257 44440 44441 44444 44442 44448 44446 44447"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [129] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 18 44257 44449 44450 44454 44264 44263 44262 44261 44260 44258 44257 44440 44441 44444 44448 44446 44447 44265"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## [130] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 7 44449 44450 44454 44264 44260 44256 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
## [131] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 11 44450 44453 44454 44264 44263 44256 44442 44448 44446 44257 44266"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [132] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 2 44449 44260"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## [133] "PMC8528285 /pmc/articles/PMC8528285/bin/pbio.3001085.s010.xlsx Hsapiens 6 44453 44442 44446 44263 44257 44266"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
## [134] "PMC8515723 /pmc/articles/PMC8515723/bin/13073_2021_965_MOESM1_ESM.xlsx Hsapiens 1 44261"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [135] "PMC8515723 /pmc/articles/PMC8515723/bin/13073_2021_965_MOESM1_ESM.xlsx Hsapiens 1 44261"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [136] "PMC8503750 /pmc/articles/PMC8503750/bin/Supplementary_Data2.xlsx Hsapiens 5 43715 43719 43717 43716 43712"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## [137] "PMC8494642 /pmc/articles/PMC8494642/bin/41586_2021_3209_MOESM4_ESM.xlsx Hsapiens 14 43891 44084 44085 43896 44082 44082 44082 44082 44082 43895 44078 44080 44080 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [138] "PMC8494642 /pmc/articles/PMC8494642/bin/41586_2021_3209_MOESM4_ESM.xlsx Hsapiens 12 44089 44089 43892 43891 43897 43896 43896 43895 44078 44078 44078 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
## [139] "PMC8516354 /pmc/articles/PMC8516354/bin/Table_1.xlsx Hsapiens 13 44445 44263 44444 44449 44441 44257 44446 44447 44443 44260 44450 44261 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
## [140] "PMC8516354 /pmc/articles/PMC8516354/bin/Table_1.xlsx Hsapiens 12 44263 44449 44260 44442 44261 44447 44445 44257 44443 44444 44441 44446"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [141] "PMC8505008 /pmc/articles/PMC8505008/bin/pgen.1009828.s015.xlsx Scerevisiae 1 44105"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [142] "PMC8505008 /pmc/articles/PMC8505008/bin/pgen.1009828.s016.xlsx Scerevisiae 2 44340 44470"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [143] "PMC8505008 /pmc/articles/PMC8505008/bin/pgen.1009828.s017.xlsx Scerevisiae 2 44470 44340"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [144] "PMC8505008 /pmc/articles/PMC8505008/bin/pgen.1009828.s017.xlsx Scerevisiae 2 44470 44340"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [145] "PMC8503558 /pmc/articles/PMC8503558/bin/Table_2.xlsx Hsapiens 1 44258"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## [146] "PMC8503558 /pmc/articles/PMC8503558/bin/Table_2.xlsx Hsapiens 1 44258"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## [147] "PMC8502891 /pmc/articles/PMC8502891/bin/Table_2.xlsx Drerio 6 44451 44446 44445 44262 44451 44262"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
## [148] "PMC8494765 /pmc/articles/PMC8494765/bin/41598_2021_99079_MOESM4_ESM.xlsx Mmusculus 104 44441 44441 44441 44441 44444 44444 44444 44444 44443 44443 44443 44443 44447 44447 44447 44447 44442 44442 44442 44442 44450 44450 44450 44450 44448 44448 44448 44448 44440 44440 44440 44440 44445 44445 44445 44445 44262 44262 44262 44262 44256 44256 44256 44256 44257 44257 44257 44257 44260 44260 44260 44260 44451 44451 44451 44451 44263 44263 44263 44263 44256 44256 44256 44256 44453 44453 44453 44453 44454 44454 44454 44454 44449 44449 44449 44449 44266 44266 44266 44266 44264 44264 44264 44264 44261 44261 44261 44261 44257 44257 44257 44257 44446 44446 44446 44446 44259 44259 44259 44259 44265 44265 44265 44265"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## [149] "PMC8476631 /pmc/articles/PMC8476631/bin/41419_2021_4176_MOESM4_ESM.xlsx Hsapiens 1 38047"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [150] "PMC8455334 /pmc/articles/PMC8455334/bin/41397_2021_237_MOESM2_ESM.xlsx Hsapiens 1 38231"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [151] "PMC8455334 /pmc/articles/PMC8455334/bin/41397_2021_237_MOESM2_ESM.xlsx Hsapiens 1 39873"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [152] "PMC8455334 /pmc/articles/PMC8455334/bin/41397_2021_237_MOESM2_ESM.xlsx Hsapiens 3 37865 38231 41153"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
## [153] "PMC8455334 /pmc/articles/PMC8455334/bin/41397_2021_237_MOESM2_ESM.xlsx Hsapiens 1 38961"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [154] "PMC8455334 /pmc/articles/PMC8455334/bin/41397_2021_237_MOESM2_ESM.xlsx Hsapiens 1 38777"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [155] "PMC8455334 /pmc/articles/PMC8455334/bin/41397_2021_237_MOESM2_ESM.xlsx Hsapiens 1 37135"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [156] "PMC8484507 /pmc/articles/PMC8484507/bin/mmc4.xlsx Hsapiens 2 43348 43170"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [157] "PMC8490889 /pmc/articles/PMC8490889/bin/Table_4.XLSX Hsapiens 26 44166 44076 43897 44080 44086 43898 44075 44079 44088 44084 44083 43900 44081 44078 44082 43901 43896 43891 43892 43893 43894 43895 43899 44089 44085 44077"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [158] "PMC8490743 /pmc/articles/PMC8490743/bin/Table_1.xlsx Hsapiens 5 44443 44256 44445 44450 44440"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
## [159] "PMC8490743 /pmc/articles/PMC8490743/bin/Table_6.xlsx Hsapiens 25 44257 44256 44449 44262 44259 44441 44450 44261 44266 44258 44447 44446 44453 44445 44531 44263 44260 44264 44451 44440 44443 44265 44448 44444 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## [160] "PMC8490743 /pmc/articles/PMC8490743/bin/Table_7.xlsx Hsapiens 26 44445 44263 44258 44444 44440 44265 44449 44266 44441 44531 44451 44453 44256 44257 44446 44447 44443 44260 44450 44261 44454 44448 44259 44262 44264 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [161] "PMC8490713 /pmc/articles/PMC8490713/bin/Table_1.xlsx Mmusculus 22 44441 44257 44262 44454 44450 44263 44440 44256 44446 44449 44264 44447 44443 44448 44266 44261 44442 44444 44257 44258 44260 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## [162] "PMC8490697 /pmc/articles/PMC8490697/bin/Table_1.XLSX Hsapiens 15 44444 44258 44256 44451 44445 44266 44259 44446 44442 44453 44261 44447 44263 44450 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
## [163] "PMC8452624 /pmc/articles/PMC8452624/bin/41467_2021_25709_MOESM12_ESM.xlsx Hsapiens 2 43712 43722"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
## [164] "PMC8452624 /pmc/articles/PMC8452624/bin/41467_2021_25709_MOESM7_ESM.xlsx Ggallus 2 43533 43532"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
## [165] "PMC8489709 /pmc/articles/PMC8489709/bin/pgen.1009801.s005.xlsx Dmelanogaster 2 43344 43347"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
## [166] "PMC8488206 /pmc/articles/PMC8488206/bin/Table_1.XLSX Hsapiens 20 44265 44448 44447 44266 44453 44261 44444 44259 44445 44260 44442 44449 44451 44262 44440 44264 44256 44441 44263 44443"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## [167] "PMC8488206 /pmc/articles/PMC8488206/bin/Table_1.XLSX Hsapiens 4 44447 44450 44441 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## [168] "PMC8488120 /pmc/articles/PMC8488120/bin/Table_1.XLSX Hsapiens 2 44450 44259"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
## [169] "PMC8449357 /pmc/articles/PMC8449357/bin/pnas.2106080118.sd03.xlsx Drerio 2 44086 44082"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## [170] "PMC8449357 /pmc/articles/PMC8449357/bin/pnas.2106080118.sd04.xlsx Drerio 4 44085 43891 44081 44079"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
## [171] "PMC8445938 /pmc/articles/PMC8445938/bin/41467_2021_25553_MOESM14_ESM.xlsx Hsapiens 16 43897 44081 43893 44085 43896 43532 43895 44082 44084 43899 44076 44083 43891 44080 44078 44077"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## [172] "PMC8445938 /pmc/articles/PMC8445938/bin/41467_2021_25553_MOESM5_ESM.xlsx Hsapiens 1 43532"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## [173] "PMC8484522 /pmc/articles/PMC8484522/bin/Table_3.xls Hsapiens 5 44259 44442 44444 44453 44266"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
## [174] "PMC8482641 /pmc/articles/PMC8482641/bin/NIHMS1656410-supplement-1656410_Sup_tab_2.xlsx Mmusculus 50 43900 44078 44083 44083 43893 43897 44081 44085 43894 43894 43900 43900 44079 44083 44083 43891 43891 43894 43894 43896 44080 44081 44081 44085 44085 44085 43897 43900 43900 44078 44082 44083 44083 43892 43892 43894 43894 43900 44078 44078 44080 44083 44083 44083 44083 44083 44083 44083 44085 44085"

In depth look at the errors

Let’s investigate the errors in more detail.

# By species
SPECIES <- sapply(strsplit(ERROR_GENELISTS," "),"[[",3)
table(SPECIES)
## SPECIES
##     Athaliana Dmelanogaster        Drerio       Ggallus      Hsapiens 
##             1            13             3             7           124 
##     Mmusculus   Scerevisiae 
##            22             4
par(mar=c(5,12,4,2))
barplot(table(SPECIES),horiz=TRUE,las=1)

par(mar=c(5,5,4,2))

# Number of affected Excel files per paper
DIST <- table(sapply(strsplit(ERROR_GENELISTS," "),"[[",1))
DIST
## 
## PMC8445938 PMC8449357 PMC8452624 PMC8455334 PMC8455578 PMC8455625 PMC8458293 
##          2          2          2          6          2          1          9 
## PMC8463701 PMC8476631 PMC8479071 PMC8481544 PMC8482641 PMC8484507 PMC8484522 
##          1          1          4          1          1          1          1 
## PMC8486213 PMC8486594 PMC8488120 PMC8488206 PMC8489709 PMC8490697 PMC8490713 
##          9          2          1          2          1          1          1 
## PMC8490743 PMC8490889 PMC8490982 PMC8492352 PMC8494642 PMC8494765 PMC8494907 
##          3          1          6          2          2          1          2 
## PMC8496489 PMC8497462 PMC8498718 PMC8498917 PMC8498966 PMC8501628 PMC8502891 
##          6          1          1          4          1          1          1 
## PMC8503558 PMC8503750 PMC8505008 PMC8505442 PMC8507324 PMC8509297 PMC8511044 
##          2          1          4          2          1         11          2 
## PMC8513875 PMC8514339 PMC8514428 PMC8515723 PMC8516354 PMC8517214 PMC8518179 
##          1          1          1          2          2          2          2 
## PMC8518362 PMC8519440 PMC8519947 PMC8521585 PMC8523829 PMC8528285 PMC8529555 
##          1          1          6          1          4         22          1 
## PMC8530322 PMC8532573 PMC8539775 PMC8544335 PMC8544599 PMC8554095 PMC8554124 
##          1          3          1          1          1          5          8 
## PMC8555832 
##          1
summary(as.numeric(DIST))
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##   1.000   1.000   1.500   2.719   2.250  22.000
hist(DIST,main="Number of affected Excel files per paper")

# PMC Articles with the most errors
DIST_DF <- as.data.frame(DIST)
DIST_DF <- DIST_DF[order(-DIST_DF$Freq),,drop=FALSE]
head(DIST_DF,20)
##          Var1 Freq
## 55 PMC8528285   22
## 41 PMC8509297   11
## 7  PMC8458293    9
## 15 PMC8486213    9
## 63 PMC8554124    8
## 4  PMC8455334    6
## 24 PMC8490982    6
## 29 PMC8496489    6
## 52 PMC8519947    6
## 62 PMC8554095    5
## 10 PMC8479071    4
## 32 PMC8498917    4
## 38 PMC8505008    4
## 54 PMC8523829    4
## 22 PMC8490743    3
## 58 PMC8532573    3
## 1  PMC8445938    2
## 2  PMC8449357    2
## 3  PMC8452624    2
## 5  PMC8455578    2
MOST_ERR_FILES = as.character(DIST_DF[1,1])
MOST_ERR_FILES
## [1] "PMC8528285"
# Number of errors per paper
NERR <- as.numeric(sapply(strsplit(ERROR_GENELISTS," "),"[[",4))
names(NERR) <- sapply(strsplit(ERROR_GENELISTS," "),"[[",1)
NERR <-tapply(NERR, names(NERR), sum)
NERR
## PMC8445938 PMC8449357 PMC8452624 PMC8455334 PMC8455578 PMC8455625 PMC8458293 
##         17          6          4          8        227          1         88 
## PMC8463701 PMC8476631 PMC8479071 PMC8481544 PMC8482641 PMC8484507 PMC8484522 
##          1          1         82          4         50          2          5 
## PMC8486213 PMC8486594 PMC8488120 PMC8488206 PMC8489709 PMC8490697 PMC8490713 
##         62         15          2         24          2         15         22 
## PMC8490743 PMC8490889 PMC8490982 PMC8492352 PMC8494642 PMC8494765 PMC8494907 
##         56         26         16        396         26        104         56 
## PMC8496489 PMC8497462 PMC8498718 PMC8498917 PMC8498966 PMC8501628 PMC8502891 
##         65          1         28         45         41          1          6 
## PMC8503558 PMC8503750 PMC8505008 PMC8505442 PMC8507324 PMC8509297 PMC8511044 
##          2          5          7         38          1         20          2 
## PMC8513875 PMC8514339 PMC8514428 PMC8515723 PMC8516354 PMC8517214 PMC8518179 
##          1         24          1          2         25          2          2 
## PMC8518362 PMC8519440 PMC8519947 PMC8521585 PMC8523829 PMC8528285 PMC8529555 
##         34         26         78          1          5        221          1 
## PMC8530322 PMC8532573 PMC8539775 PMC8544335 PMC8544599 PMC8554095 PMC8554124 
##          1         81          2          1         13         36         56 
## PMC8555832 
##          5
hist(NERR,main="number of errors per PMC article")

NERR_DF <- as.data.frame(NERR)
NERR_DF <- NERR_DF[order(-NERR_DF$NERR),,drop=FALSE]
head(NERR_DF,20)
##            NERR
## PMC8492352  396
## PMC8455578  227
## PMC8528285  221
## PMC8494765  104
## PMC8458293   88
## PMC8479071   82
## PMC8532573   81
## PMC8519947   78
## PMC8496489   65
## PMC8486213   62
## PMC8490743   56
## PMC8494907   56
## PMC8554124   56
## PMC8482641   50
## PMC8498917   45
## PMC8498966   41
## PMC8505442   38
## PMC8554095   36
## PMC8518362   34
## PMC8498718   28
MOST_ERR = rownames(NERR_DF)[1]
MOST_ERR
## [1] "PMC8492352"

Journals affected

GENELIST_ERROR_ARTICLES <- gsub("PMC","",GENELIST_ERROR_ARTICLES)

### JSON PARSING is more reliable than XML
ARTICLES <- esummary( GENELIST_ERROR_ARTICLES , db="pmc" , retmode = "json"  )
ARTICLE_DATA <- reutils::content(ARTICLES,as= "parsed")
ARTICLE_DATA <- ARTICLE_DATA$result
ARTICLE_DATA <- ARTICLE_DATA[2:length(ARTICLE_DATA)]
JOURNALS <- unlist(lapply(ARTICLE_DATA,function(x) {x$fulljournalname} ))
JOURNALS_TABLE <- table(JOURNALS)
JOURNALS_TABLE <- JOURNALS_TABLE[order(-JOURNALS_TABLE)]

length(JOURNALS_TABLE)
## [1] 34
NUM_JOURNALS=length(JOURNALS_TABLE)

par(mar=c(5,25,4,2))
barplot(head(JOURNALS_TABLE,10), horiz=TRUE, las=1, 
  xlab="Articles with gene name errors in supp files",
  main="Top journals this month")

Journal of the month winner

Congrats to our Journal of the Month winner!

JOURNAL_WINNER <- names(head(JOURNALS_TABLE,1))
JOURNAL_WINNER
## [1] "Nature Communications"

Paper of the month winners

There are two categories:

Sometimes, one paper can win both categories. Congrats to our winners.

Paper with most files affected

MOST_ERR_FILES <- gsub("PMC","",MOST_ERR_FILES)
ARTICLES <- esummary( MOST_ERR_FILES , db="pmc" , retmode = "json"  )
ARTICLE_DATA <- reutils::content(ARTICLES,as= "parsed")
ARTICLE_DATA <- ARTICLE_DATA[2]
ARTICLE_DATA
## $result
## $result$uids
## [1] "8528285"
## 
## $result$`8528285`
## $result$`8528285`$uid
## [1] "8528285"
## 
## $result$`8528285`$pubdate
## [1] "2021 Oct 20"
## 
## $result$`8528285`$epubdate
## [1] "2021 Oct 20"
## 
## $result$`8528285`$printpubdate
## [1] ""
## 
## $result$`8528285`$source
## [1] "PLoS Biol"
## 
## $result$`8528285`$authors
##               name authtype
## 1       Carroll PA   Author
## 2         Freie BW   Author
## 3         Cheng PF   Author
## 4     Kasinathan S   Author
## 5             Gu H   Author
## 6        Hedrich T   Author
## 7        Dowdle JA   Author
## 8  Venkataramani V   Author
## 9         Ramani V   Author
## 10            Wu X   Author
## 11       Raftery D   Author
## 12      Shendure J   Author
## 13         Ayer DE   Author
## 14       Muller CH   Author
## 15     Eisenman RN   Author
## 
## $result$`8528285`$title
## [1] "The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis"
## 
## $result$`8528285`$volume
## [1] "19"
## 
## $result$`8528285`$issue
## [1] "10"
## 
## $result$`8528285`$pages
## [1] "e3001085"
## 
## $result$`8528285`$articleids
##   idtype                        value
## 1   pmid                     34669700
## 2    doi 10.1371/journal.pbio.3001085
## 3  pmcid                   PMC8528285
## 
## $result$`8528285`$fulljournalname
## [1] "PLoS Biology"
## 
## $result$`8528285`$sortdate
## [1] "2021/10/20 00:00"
## 
## $result$`8528285`$pmclivedate
## [1] "2021/10/21"

Paper with most date conversions

MOST_ERR <- gsub("PMC","",MOST_ERR)
ARTICLE_DATA <- esummary(MOST_ERR,db = "pmc" , retmode = "json" )
ARTICLE_DATA <- reutils::content(ARTICLE_DATA,as= "parsed")
ARTICLE_DATA
## $header
## $header$type
## [1] "esummary"
## 
## $header$version
## [1] "0.3"
## 
## 
## $result
## $result$uids
## [1] "8492352"
## 
## $result$`8492352`
## $result$`8492352`$uid
## [1] "8492352"
## 
## $result$`8492352`$pubdate
## [1] "2021 Sep 8"
## 
## $result$`8492352`$epubdate
## [1] "2021 Sep 8"
## 
## $result$`8492352`$printpubdate
## [1] ""
## 
## $result$`8492352`$source
## [1] "JCI Insight"
## 
## $result$`8492352`$authors
##            name authtype
## 1        Yun JH   Author
## 2         Lee C   Author
## 3         Liu T   Author
## 4         Liu S   Author
## 5        Kim EY   Author
## 6          Xu S   Author
## 7     Curtis JL   Author
## 8     Pinello L   Author
## 9     Bowler RP   Author
## 10 Silverman EK   Author
## 11     Hersh CP   Author
## 12       Zhou X   Author
## 
## $result$`8492352`$title
## [1] "Hedgehog interacting protein–expressing lung fibroblasts suppress lymphocytic inflammation in mice"
## 
## $result$`8492352`$volume
## [1] "6"
## 
## $result$`8492352`$issue
## [1] "17"
## 
## $result$`8492352`$pages
## [1] "e144575"
## 
## $result$`8492352`$articleids
##   idtype                      value
## 1   pmid                   34375314
## 2    doi 10.1172/jci.insight.144575
## 3  pmcid                 PMC8492352
## 
## $result$`8492352`$fulljournalname
## [1] "JCI Insight"
## 
## $result$`8492352`$sortdate
## [1] "2021/09/08 00:00"
## 
## $result$`8492352`$pmclivedate
## [1] "2021/10/07"

Trend info

To plot the trend over the past 6-12 months.

url <- "http://ziemann-lab.net/public/gene_name_errors/"
doc <- htmlParse(url)
links <- xpathSApply(doc, "//a/@href")
links <- links[grep("html",links)]

links
##                  href                  href                  href 
## "Report_2021-02.html" "Report_2021-03.html" "Report_2021-04.html" 
##                  href                  href                  href 
## "Report_2021-05.html" "Report_2021-06.html" "Report_2021-07.html" 
##                  href                  href                  href 
## "Report_2021-08.html" "Report_2021-09.html" "Report_2021-10.html"
unlink("online_files/",recursive=TRUE)

dir.create("online_files")

sapply(links, function(mylink) { 
  download.file(paste(url,mylink,sep=""),destfile=paste("online_files/",mylink,sep=""))  
} )
## href href href href href href href href href 
##    0    0    0    0    0    0    0    0    0
myfilelist <- list.files("online_files/",full.names=TRUE)

trends <- sapply(myfilelist,  function(myfilename) {

  x <- readLines(myfilename)

  # Num XL gene list articles
  NUM_GENELIST_ARTICLES <- x[grep("NUM_GENELIST_ARTICLES",x)[3]+1]
  NUM_GENELIST_ARTICLES <- sapply(strsplit(NUM_GENELIST_ARTICLES," "),"[[",3)
  NUM_GENELIST_ARTICLES <- sapply(strsplit(NUM_GENELIST_ARTICLES,"<"),"[[",1)
  NUM_GENELIST_ARTICLES <- as.numeric(NUM_GENELIST_ARTICLES)

  # number of affected articles
  NUM_ERROR_GENELIST_ARTICLES <- x[grep("NUM_ERROR_GENELIST_ARTICLES",x)[3]+1]
  NUM_ERROR_GENELIST_ARTICLES <- sapply(strsplit(NUM_ERROR_GENELIST_ARTICLES," "),"[[",3)
  NUM_ERROR_GENELIST_ARTICLES <- sapply(strsplit(NUM_ERROR_GENELIST_ARTICLES,"<"),"[[",1)
  NUM_ERROR_GENELIST_ARTICLES <- as.numeric(NUM_ERROR_GENELIST_ARTICLES)

  # Error proportion
  ERROR_PROPORTION <- x[grep("ERROR_PROPORTION",x)[3]+1]
  ERROR_PROPORTION <- sapply(strsplit(ERROR_PROPORTION," "),"[[",3)
  ERROR_PROPORTION <- sapply(strsplit(ERROR_PROPORTION,"<"),"[[",1)
  ERROR_PROPORTION <- as.numeric(ERROR_PROPORTION)

  # number of journals
  NUM_JOURNALS <- x[grep('JOURNALS_TABLE',x)[3]+1]
  NUM_JOURNALS <- sapply(strsplit(NUM_JOURNALS," "),"[[",3)
  NUM_JOURNALS <- sapply(strsplit(NUM_JOURNALS,"<"),"[[",1)
  NUM_JOURNALS <- as.numeric(NUM_JOURNALS)
  NUM_JOURNALS

  res <- c(NUM_GENELIST_ARTICLES,NUM_ERROR_GENELIST_ARTICLES,ERROR_PROPORTION,NUM_JOURNALS)

  return(res)
})

colnames(trends) <- sapply(strsplit(colnames(trends),"_"),"[[",3)
colnames(trends) <- gsub(".html","",colnames(trends))
trends <- as.data.frame(trends)
rownames(trends) <- c("NUM_GENELIST_ARTICLES","NUM_ERROR_GENELIST_ARTICLES","ERROR_PROPORTION","NUM_JOURNALS")
trends <- t(trends)
trends <- as.data.frame(trends)

CURRENT_RES <- c(NUM_GENELIST_ARTICLES,NUM_ERROR_GENELIST_ARTICLES,ERROR_PROPORTION,NUM_JOURNALS)

trends <- rbind(trends,CURRENT_RES)
paste(CURRENT_YEAR,CURRENT_MONTH,sep="-")
## [1] "2021-11"
rownames(trends)[nrow(trends)] <- paste(CURRENT_YEAR,CURRENT_MONTH,sep="-")

plot(trends$NUM_GENELIST_ARTICLES, xaxt = "n" , type="b" , main="Number of articles with Excel gene lists per month",
 ylab="number of articles", xlab="month")
axis(1, at=1:nrow(trends), labels=rownames(trends))

plot(trends$NUM_ERROR_GENELIST_ARTICLES, xaxt = "n" , type="b" , main="Number of articles with gene name errors per month",
 ylab="number of articles", xlab="month")
axis(1, at=1:nrow(trends), labels=rownames(trends))

plot(trends$ERROR_PROPORTION, xaxt = "n" , type="b" , main="Proportion of articles with Excel gene list affected by errors",
 ylab="proportion", xlab="month")
axis(1, at=1:nrow(trends), labels=rownames(trends))

plot(trends$NUM_JOURNALS, xaxt = "n" , type="b" , main="Number of journals with affected articles",
 ylab="number of journals", xlab="month")
axis(1, at=1:nrow(trends), labels=rownames(trends))

unlink("online_files/",recursive=TRUE)

References

  1. Zeeberg, B.R., Riss, J., Kane, D.W. et al. Mistaken Identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics. BMC Bioinformatics 5, 80 (2004). https://doi.org/10.1186/1471-2105-5-80

  2. Ziemann, M., Eren, Y. & El-Osta, A. Gene name errors are widespread in the scientific literature. Genome Biol 17, 177 (2016). https://doi.org/10.1186/s13059-016-1044-7

SessionInfo

sessionInfo()
## R version 4.1.1 (2021-08-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
## [1] readxl_1.3.1   reutils_0.2.3  xml2_1.3.2     jsonlite_1.7.2 XML_3.99-0.8  
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.7       knitr_1.36       magrittr_2.0.1   R6_2.5.1        
##  [5] rlang_0.4.12     fastmap_1.1.0    stringr_1.4.0    highr_0.9       
##  [9] tools_4.1.1      xfun_0.27        jquerylib_0.1.4  htmltools_0.5.2 
## [13] yaml_2.2.1       digest_0.6.28    assertthat_0.2.1 sass_0.4.0      
## [17] bitops_1.0-7     RCurl_1.98-1.5   evaluate_0.14    rmarkdown_2.11  
## [21] stringi_1.7.5    compiler_4.1.1   bslib_0.3.1      cellranger_1.1.0