Source: https://github.com/markziemann/GeneNameErrors2020

View the reports: http://ziemann-lab.net/public/gene_name_errors/

Intro

Gene name errors result when data are imported improperly into MS Excel and other spreadsheet programs (Zeeberg et al, 2004). Certain gene names like MARCH3, SEPT2 and DEC1 are converted into date format. These errors are surprisingly common in supplementary data files in the field of genomics (Ziemann et al, 2016). This could be considered a small error because it only affects a small number of genes, however it is symptomtic of poor data processing methods. The purpose of this script is to identify gene name errors present in supplementary files of PubMed Central articles in the previous month.

library("XML")
library("jsonlite")
library("xml2")
library("reutils")
library("readxl")

Get PMC IDs

Here I will be getting PubMed Central IDs for the previous month.

Start with figuring out the date to search PubMed Central.

CURRENT_MONTH=format(Sys.time(), "%m")
CURRENT_YEAR=format(Sys.time(), "%Y")

if (CURRENT_MONTH == "01") {
  PREV_YEAR=as.character(as.numeric(format(Sys.time(), "%Y"))-1)
  PREV_MONTH="12"
} else {
  PREV_YEAR=CURRENT_YEAR
  PREV_MONTH=as.character(as.numeric(format(Sys.time(), "%m"))-1)
}

DATE=paste(PREV_YEAR,"/",PREV_MONTH,sep="")
DATE
## [1] "2022/1"

Let’s see how many PMC IDs we have in the past month.

QUERY ='((genom*[Abstract]))'

ESEARCH_RES <- esearch(term=QUERY, db = "pmc", rettype = "uilist", retmode = "xml", retstart = 0, 
  retmax = 5000000, usehistory = TRUE, webenv = NULL, querykey = NULL, sort = NULL, field = NULL, 
  datetype = NULL, reldate = NULL, mindate = DATE, maxdate = DATE)

pmc <- efetch(ESEARCH_RES,retmode="text",rettype="uilist",outfile="pmcids.txt")
## Retrieving UIDs 1 to 500
## Retrieving UIDs 501 to 1000
## Retrieving UIDs 1001 to 1500
## Retrieving UIDs 1501 to 2000
## Retrieving UIDs 2001 to 2500
## Retrieving UIDs 2501 to 3000
## Retrieving UIDs 3001 to 3500
pmc <- read.table(pmc)
pmc <- paste("PMC",pmc$V1,sep="")
NUM_ARTICLES=length(pmc)
NUM_ARTICLES
## [1] 3051
writeLines(pmc,con="pmc.txt")

Run the screen

Now run the bash script. Note that false positives can occur (~1.5%) and these results have not been verified by a human.

Here are some definitions:

system("./gene_names.sh pmc.txt")
results <- readLines("results.txt")

XLS <- results[grep("XLS",results,ignore.case=TRUE)]
NUM_XLS = length(XLS)
NUM_XLS
## [1] 4780
NUM_XLS_ARTICLES = length(unique(sapply(strsplit(XLS," "),"[[",1)))
NUM_XLS_ARTICLES
## [1] 709
GENELISTS <- XLS[lapply(strsplit(XLS," "),length)>2]
#GENELISTS

NUM_GENELISTS <- length(unique(sapply(strsplit(GENELISTS," "),"[[",2)))
NUM_GENELISTS
## [1] 522
NUM_GENELIST_ARTICLES <- length(unique(sapply(strsplit(GENELISTS," "),"[[",1)))
NUM_GENELIST_ARTICLES
## [1] 265
ERROR_GENELISTS <- XLS[lapply(strsplit(XLS," "),length)>3]
#ERROR_GENELISTS

NUM_ERROR_GENELISTS = length(ERROR_GENELISTS)
NUM_ERROR_GENELISTS
## [1] 368
GENELIST_ERROR_ARTICLES <- unique(sapply(strsplit(ERROR_GENELISTS," "),"[[",1))
GENELIST_ERROR_ARTICLES
##  [1] "PMC8800370" "PMC8794705" "PMC8792904" "PMC8789167" "PMC8786741"
##  [6] "PMC8782480" "PMC8776252" "PMC8773395" "PMC8769648" "PMC8713813"
## [11] "PMC8713784" "PMC8770739" "PMC8755833" "PMC8752600" "PMC8751407"
## [16] "PMC8748537" "PMC8767772" "PMC8766719" "PMC8762874" "PMC8756499"
## [21] "PMC8692330" "PMC8761743" "PMC8753122" "PMC8738961" "PMC8757482"
## [26] "PMC8744257" "PMC8742043" "PMC8742041" "PMC8744399" "PMC8741763"
## [31] "PMC8741844" "PMC8741300" "PMC8724844" "PMC8733947" "PMC8733896"
## [36] "PMC8725365" "PMC8719881" "PMC8724546" "PMC8724129" "PMC8688513"
## [41] "PMC8674242" "PMC8668906" "PMC8797262" "PMC8792531" "PMC8787225"
## [46] "PMC8756151" "PMC8739494" "PMC8781439" "PMC8754154" "PMC8780294"
## [51] "PMC8777075" "PMC8713981" "PMC8762462" "PMC8758788" "PMC8752785"
## [56] "PMC8748879" "PMC8762886" "PMC8760727" "PMC8759260" "PMC8756637"
## [61] "PMC8732846" "PMC8732282" "PMC8728658" "PMC8762721" "PMC8762282"
## [66] "PMC8746912" "PMC8711282" "PMC8749219" "PMC8728608" "PMC8747517"
## [71] "PMC8750853" "PMC8748700" "PMC8748539" "PMC8742585" "PMC8740005"
## [76] "PMC8739483" "PMC8739361" "PMC8719428" "PMC8722201" "PMC8669064"
## [81] "PMC8722433" "PMC8690928" "PMC8718409"
NUM_ERROR_GENELIST_ARTICLES <- length(GENELIST_ERROR_ARTICLES) 
NUM_ERROR_GENELIST_ARTICLES
## [1] 83
ERROR_PROPORTION = NUM_ERROR_GENELIST_ARTICLES / NUM_GENELIST_ARTICLES
ERROR_PROPORTION
## [1] 0.3132075

Look at the errors detected

Here you can have a look at all the gene lists detected in the past month, as well as those with errors. The dates are obvious errors, these are commonly dates in September, March, December and October. The five-digit numbers represent dates as they are encoded in the Excel internal format. The five digit number is the number of days since 1900. If you were to take these numbers and put them into Excel and format the cells as dates, then these will also mostly map to dates in September, March, December and October.

#GENELISTS

ERROR_GENELISTS
##   [1] "PMC8800370 /pmc/articles/PMC8800370/bin/NIHMS1769771-supplement-Supplemental_Table_1.xlsx Ggallus 309 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##   [2] "PMC8800370 /pmc/articles/PMC8800370/bin/NIHMS1769771-supplement-Supplemental_Table_1.xlsx Hsapiens 22 44256 44256 44256 44256 44446 44531 44531 44256 44259 44256 44256 44446 44446 44263 44263 44263 44259 44259 44259 44446 44531 44531"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [3] "PMC8800370 /pmc/articles/PMC8800370/bin/NIHMS1769771-supplement-Supplemental_Table_3.xlsx Hsapiens 6 44531 44256 44265 44266 44259 44263"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##   [4] "PMC8794705 /pmc/articles/PMC8794705/bin/Table_2.XLSX Hsapiens 1 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##   [5] "PMC8794705 /pmc/articles/PMC8794705/bin/Table_2.XLSX Ggallus 1 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
##   [6] "PMC8794705 /pmc/articles/PMC8794705/bin/Table_2.XLSX Ggallus 13 44442 44442 44448 44443 44443 44443 44443 44443 44443 44445 44445 44445 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##   [7] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_4.xlsx Hsapiens 7 44447 44442 44447 44442 44442 44443 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [8] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_5.xlsx Hsapiens 7 44447 44442 44447 44442 44442 44443 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [9] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_5.xlsx Hsapiens 159 44261 44449 44445 44445 44447 44443 44260 44256 44262 44261 44447 44259 44446 44261 44447 44266 44441 44531 44260 44257 44442 44454 44258 44445 44260 44450 44262 44447 44260 44262 44449 44260 44256 44446 44449 44447 44257 44446 44261 44449 44445 44447 44257 44260 44262 44454 44446 44440 44445 44453 44266 44453 44446 44261 44449 44447 44441 44531 44450 44256 44446 44261 44447 44450 44442 44447 44442 44447 44441 44260 44264 44445 44441 44257 44260 44262 44454 44261 44440 44263 44445 44447 44453 44266 44441 44257 44262 44446 44261 44258 44449 44447 44443 44442 44259 44262 44446 44445 44531 44450 44446 44440 44531 44444 44449 44445 44447 44441 44260 44262 44258 44449 44447 44256 44442 44262 44447 44256 44450 44259 44262 44443 44260 44258 44258 44445 44443 44262 44453 44442 44264 44447 44531 44256 44454 44256 44440 44262 44261 44258 44447 44257 44256 44450 44442 44454 44449 44443 44454 44443 44257 44258 44449 44453 44441 44260 44256 44447 44441"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
##  [10] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_5.xlsx Hsapiens 26 44448 44442 44449 44445 44447 44443 44263 44447 44442 44442 44447 44446 44447 44450 44260 44450 44442 44447 44447 44443 44450 44441 44442 44441 44443 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [11] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_5.xlsx Hsapiens 292 44442 44261 44258 44447 44443 44260 44256 44450 44256 44262 44261 44445 44447 44256 44442 44259 44261 44260 44257 44450 44442 44264 44258 44260 44450 44262 44256 44262 44263 44445 44256 44258 44449 44447 44450 44446 44257 44260 44451 44453 44257 44256 44262 44261 44448 44449 44453 44450 44256 44453 44257 44442 44263 44447 44442 44259 44447 44441 44260 44257 44260 44262 44261 44263 44445 44453 44441 44256 44450 44262 44264 44446 44265 44441 44256 44442 44448 44445 44442 44261 44258 44531 44256 44450 44262 44261 44263 44447 44256 44262 44264 44448 44445 44453 44441 44260 44450 44261 44258 44449 44453 44441 44256 44450 44442 44259 44261 44258 44263 44260 44259 44258 44443 44260 44261 44263 44447 44441 44450 44258 44442 44262 44261 44448 44258 44445 44447 44441 44260 44257 44256 44442 44262 44441 44256 44450 44445 44443 44261 44448 44449 44447 44256 44256 44262 44258 44263 44260 44256 44262 44261 44258 44447 44453 44441 44257 44256 44450 44442 44262 44261 44449 44441 44443 44450 44442 44259 44262 44258 44263 44443 44442 44259 44261 44258 44260 44256 44262 44261 44263 44447 44441 44257 44450 44442 44262 44264 44449 44257 44261 44448 44263 44257 44442 44264 44263 44441 44450 44262 44445 44256 44448 44447 44264 44265 44263 44445 44256 44442 44448 44265 44263 44450 44259 44256 44261 44448 44265 44263 44445 44257 44256 44450 44264 44261 44263 44445 44256 44442 44259 44264 44261 44448 44447 44259 44256 44258 44440 44261 44440 44257 44450 44440 44261 44448 44258 44445 44257 44450 44442 44259 44264 44261 44448 44265 44263 44445 44447 44443 44450 44442 44259 44264 44261 44448 44258 44449 44445 44453 44443 44260 44442 44264 44263 44445 44447 44453 44260 44256 44450 44262 44261 44258 44263 44260 44442 44264 44261 44258 44265 44260 44442"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [12] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_7.xlsx Hsapiens 1 44443"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [13] "PMC8792904 /pmc/articles/PMC8792904/bin/Table_9.xlsx Hsapiens 7 44082 44077 44082 44077 44077 44078 44077"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [14] "PMC8789167 /pmc/articles/PMC8789167/bin/pone.0261293.s010.xlsx Hsapiens 22 44088 44075 44086 44085 43898 43892 44080 43892 43893 44082 43897 43894 44076 44081 43896 44083 43900 44078 44084 43901 43899 43895"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [15] "PMC8789167 /pmc/articles/PMC8789167/bin/pone.0261293.s011.xlsx Hsapiens 1 43893"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##  [16] "PMC8786741 /pmc/articles/PMC8786741/bin/Table1.XLS Hsapiens 4 2022/03/11 2022/03/01 2022/09/03 2022/03/04"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [17] "PMC8782480 /pmc/articles/PMC8782480/bin/pone.0262051.s015.xlsx Hsapiens 17 41153 41883 38412 39508 39142 38047 39326 37865 36951 40787 39692 37681 40422 40238 40057 40603 38777"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [18] "PMC8776252 /pmc/articles/PMC8776252/bin/elife-74153-supp3.xlsx Hsapiens 3 37316 36951 37226"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
##  [19] "PMC8773395 /pmc/articles/PMC8773395/bin/13577_2022_672_MOESM4_ESM.xlsx Hsapiens 1 37834"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [20] "PMC8769648 /pmc/articles/PMC8769648/bin/elife-68224-fig1-data5.xlsx Drerio 9 44451 44449 44348 11567 22525 44349 44350 44351 44441"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [21] "PMC8769648 /pmc/articles/PMC8769648/bin/elife-68224-fig1-data5.xlsx Drerio 10 44451 44449 44442 44445 44449 44451 44449 44449 44441 44451"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [22] "PMC8769648 /pmc/articles/PMC8769648/bin/elife-68224-fig5-data2.xlsx Drerio 7 44080 44089 44076 43898 44445 44454 44454"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##  [23] "PMC8713813 /pmc/articles/PMC8713813/bin/pnas.2112836118.sd04.xlsx Scerevisiae 1 44287"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [24] "PMC8713784 /pmc/articles/PMC8713784/bin/pnas.2111920118.sd04.xlsx Hsapiens 6 44266 44258 44449 44442 44445 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [25] "PMC8713784 /pmc/articles/PMC8713784/bin/pnas.2111920118.sd04.xlsx Hsapiens 1 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [26] "PMC8713784 /pmc/articles/PMC8713784/bin/pnas.2111920118.sd04.xlsx Hsapiens 1 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
##  [27] "PMC8713784 /pmc/articles/PMC8713784/bin/pnas.2111920118.sd04.xlsx Hsapiens 2 44263 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##  [28] "PMC8770739 /pmc/articles/PMC8770739/bin/Table1.xls Hsapiens 1 43534"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [29] "PMC8755833 /pmc/articles/PMC8755833/bin/41467_2021_27704_MOESM3_ESM.xlsx Mmusculus 2 40057 40787"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [30] "PMC8755833 /pmc/articles/PMC8755833/bin/41467_2021_27704_MOESM4_ESM.xlsx Hsapiens 3 38596 40057 38961"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [31] "PMC8755833 /pmc/articles/PMC8755833/bin/41467_2021_27704_MOESM4_ESM.xlsx Hsapiens 5 44257 44447 44256 44264 44446"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [32] "PMC8755833 /pmc/articles/PMC8755833/bin/41467_2021_27704_MOESM4_ESM.xlsx Hsapiens 4 40422 37135 38596 39692"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
##  [33] "PMC8755833 /pmc/articles/PMC8755833/bin/41467_2021_27704_MOESM6_ESM.xlsx Hsapiens 6 44440 44448 44446 44260 44441 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [34] "PMC8755833 /pmc/articles/PMC8755833/bin/41467_2021_27704_MOESM6_ESM.xlsx Hsapiens 6 44440 44448 44446 44260 44441 44445"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [35] "PMC8752600 /pmc/articles/PMC8752600/bin/41467_2021_27865_MOESM3_ESM.xls Mmusculus 23 44075 44081 44082 44084 44078 43901 44077 44086 43895 43898 44076 43897 43893 43891 44089 43896 43899 44080 44085 44083 44079 43900 43892"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [36] "PMC8752600 /pmc/articles/PMC8752600/bin/41467_2021_27865_MOESM9_ESM.xlsx Mmusculus 17 11-Sep 10-Sep 10-Sep 8-Sep 9-Mar 9-Sep 11-Sep 8-Mar 10-Sep 8-Sep 7-Mar 7-Sep 2-Mar 6-Mar 11-Sep 7-Mar 8-Mar"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [37] "PMC8752600 /pmc/articles/PMC8752600/bin/41467_2021_27865_MOESM9_ESM.xlsx Mmusculus 23 12-Sep 10-Mar 1-Sep 3-Sep 11-Mar 5-Sep 15-Sep 6-Sep 8-Sep 3-Mar 2-Mar 7-Sep 10-Sep 11-Sep 5-Mar 2-Sep 9-Sep 1-Mar 6-Mar 7-Mar 9-Mar 8-Mar 4-Sep"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [38] "PMC8751407 /pmc/articles/PMC8751407/bin/supp_mcs.a006113_Supplemental_Table_S2.xlsx Hsapiens 29 37500 40787 40057 39326 40422 39142 39692 38777 38412 38961 37681 37316 38596 36951 39873 39508 37135 38047 38231 37316 36951 40238 37226 37865 39508 41153 41883 40603 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [39] "PMC8748537 /pmc/articles/PMC8748537/bin/41467_2021_27670_MOESM4_ESM.xlsx Hsapiens 3 42988 42982 42803"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [40] "PMC8748537 /pmc/articles/PMC8748537/bin/41467_2021_27670_MOESM4_ESM.xlsx Hsapiens 1 42992"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [41] "PMC8767772 /pmc/articles/PMC8767772/bin/43856_2021_42_MOESM2_ESM.xlsx Hsapiens 21 44448 44261 44261 44448 44256 44444 44441 44448 44262 44256 44448 44444 44259 44261 44266 44256 44448 44266 44259 44445 44446"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##  [42] "PMC8767772 /pmc/articles/PMC8767772/bin/43856_2021_42_MOESM3_ESM.xlsx Hsapiens 2 44261 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [43] "PMC8767772 /pmc/articles/PMC8767772/bin/43856_2021_42_MOESM4_ESM.xlsx Hsapiens 2 44446 44446"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
##  [44] "PMC8767772 /pmc/articles/PMC8767772/bin/43856_2021_42_MOESM5_ESM.xlsx Hsapiens 961 44448 44261 44261 44448 44256 44444 44441 44448 44262 44256 44448 44444 44259 44261 44266 44256 44448 44266 44259 44445 44446 44448 44448 44266 44266 44266 44265 44448 44258 44448 44448 44256 44257 44266 44256 44259 44448 44448 44266 44448 44258 44448 44441 44256 44448 44450 44256 44447 44444 44446 44448 44448 44257 44447 44266 44448 44265 44448 44262 44256 44256 44531 44259 44448 44257 44258 44256 44448 44440 44448 44445 44449 44449 44265 44448 44448 44448 44262 44448 44256 44531 44256 44265 44264 44259 44257 44443 44256 44448 44265 44256 44262 44449 44448 44449 44448 44258 44446 44445 44445 44448 44256 44448 44448 44261 44448 44448 44531 44263 44257 44448 44445 44445 44531 44448 44448 44448 44531 44256 44448 44442 44445 44258 44448 44448 44258 44446 44256 44446 44256 44444 44448 44265 44265 44256 44258 44257 44448 44259 44445 44450 44263 44448 44448 44448 44448 44449 44448 44448 44531 44450 44258 44454 44262 44263 44258 44446 44450 44256 44443 44445 44266 44448 44445 44259 44448 44260 44265 44265 44442 44256 44442 44447 44448 44256 44451 44531 44258 44263 44259 44448 44448 44256 44258 44263 44258 44448 44256 44256 44450 44256 44266 44263 44448 44265 44448 44256 44258 44262 44449 44448 44258 44448 44448 44257 44256 44258 44259 44448 44451 44256 44256 44258 44256 44531 44445 44448 44448 44259 44256 44266 44445 44443 44442 44256 44450 44450 44440 44256 44444 44448 44531 44263 44447 44447 44450 44265 44448 44261 44257 44448 44256 44256 44448 44259 44264 44450 44447 44258 44258 44260 44259 44448 44259 44256 44445 44259 44265 44448 44448 44448 44257 44265 44449 44448 44262 44262 44450 44256 44261 44448 44256 44448 44448 44448 44448 44450 44256 44445 44257 44448 44260 44450 44266 44259 44448 44259 44452 44265 44450 44265 44265 44447 44263 44256 44445 44257 44263 44261 44448 44259 44446 44447 44263 44259 44447 44447 44452 44445 44531 44260 44452 44448 44256 44259 44259 44265 44444 44447 44447 44446 44440 44261 44259 44256 44266 44446 44448 44257 44259 44531 44448 44258 44448 44448 44259 44265 44448 44448 44448 44257 44448 44448 44448 44444 44448 44259 44448 44448 44266 44448 44441 44531 44448 44448 44450 44258 44448 44448 44531 44448 44448 44258 44448 44447 44265 44261 44263 44256 44257 44258 44448 44258 44265 44531 44263 44448 44263 44444 44450 44260 44263 44450 44450 44262 44445 44448 44448 44448 44445 44450 44265 44445 44451 44448 44261 44258 44262 44442 44256 44448 44441 44449 44448 44443 44448 44256 44256 44266 44444 44448 44448 44454 44448 44450 44448 44265 44447 44448 44448 44261 44258 44451 44442 44262 44261 44262 44259 44448 44441 44448 44531 44261 44259 44259 44256 44448 44448 44448 44448 44448 44257 44258 44256 44448 44450 44447 44263 44256 44448 44441 44261 44260 44263 44448 44266 44442 44448 44266 44447 44450 44263 44448 44448 44261 44258 44448 44448 44256 44261 44531 44264 44263 44263 44448 44448 44262 44452 44256 44445 44266 44256 44263 44265 44450 44453 44259 44453 44445 44450 44441 44447 44448 44263 44448 44256 44448 44259 44257 44448 44448 44450 44448 44445 44443 44257 44261 44258 44448 44261 44531 44443 44451 44441 44531 44448 44263 44260 44262 44265 44450 44256 44442 44447 44449 44259 44259 44446 44260 44447 44263 44265 44443 44258 44266 44448 44448 44531 44448 44446 44258 44256 44256 44259 44450 44259 44449 44257 44259 44449 44266 44264 44448 44448 44453 44448 44442 44265 44265 44261 44265 44256 44440 44443 44258 44448 44448 44448 44266 44257 44450 44264 44256 44449 44531 44262 44261 44257 44256 44441 44266 44448 44448 44447 44442 44259 44450 44445 44450 44442 44531 44448 44531 44447 44448 44262 44531 44266 44256 44445 44259 44262 44448 44266 44448 44448 44443 44261 44448 44444 44448 44256 44258 44531 44442 44259 44265 44256 44256 44448 44448 44450 44445 44259 44450 44448 44445 44450 44452 44261 44265 44447 44450 44448 44257 44454 44258 44262 44531 44447 44444 44263 44259 44256 44447 44257 44257 44445 44258 44257 44450 44266 44266 44450 44450 44264 44450 44448 44448 44446 44448 44448 44446 44264 44448 44441 44441 44258 44446 44448 44261 44445 44447 44256 44446 44259 44259 44444 44450 44448 44448 44259 44448 44442 44257 44256 44260 44265 44258 44448 44450 44448 44447 44448 44258 44258 44447 44445 44261 44450 44448 44260 44448 44442 44263 44443 44263 44450 44445 44259 44448 44448 44259 44261 44256 44259 44448 44448 44444 44445 44531 44257 44263 44448 44263 44443 44263 44448 44448 44531 44531 44261 44450 44259 44448 44450 44447 44256 44447 44257 44448 44263 44447 44450 44447 44448 44444 44448 44263 44446 44256 44263 44256 44448 44440 44258 44445 44256 44445 44440 44265 44447 44266 44448 44258 44261 44445 44444 44444 44256 44259 44259 44448 44448 44261 44531 44257 44265 44261 44263 44264 44256 44448 44445 44450 44262 44448 44263 44258 44256 44261 44260 44448 44443 44441 44447 44445 44448 44444 44256 44262 44449 44256 44448 44257 44261 44260 44447 44261 44448 44445 44448 44258 44448 44448 44448 44262 44448 44265 44257 44265 44256 44264 44448 44450 44447 44256 44448 44448 44448 44448 44259 44450 44259 44450 44448 44257 44258 44261 44448 44266 44258 44263 44448 44449 44448 44447 44446 44448 44257 44448 44261 44448 44260 44266 44443 44448 44258 44448 44265 44258 44256 44451 44447 44445 44259 44440 44259 44450 44259 44531 44259 44259 44446 44450 44447 44444 44444 44450 44263 44448 44261 44258 44265 44443 44450 44450 44258 44256 44261 44445 44259 44531 44450 44259 44448 44261 44442 44448 44441 44446 44256 44261 44265 44263 44448 44444 44258 44448 44258 44261 44265 44262 44448 44259 44446 44256 44445 44445 44257 44448 44531 44446 44257 44447 44447 44258 44445 44443 44447 44258 44259 44256 44450 44448 44256 44264 44440 44262 44448 44261 44447 44444 44447 44264 44263 44445 44450 44448 44448 44531 44448 44265 44263 44256 44265 44450 44262 44442 44448 44448"
##  [45] "PMC8766719 /pmc/articles/PMC8766719/bin/Table_2.xlsx Hsapiens 1 44454"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
##  [46] "PMC8762874 /pmc/articles/PMC8762874/bin/12860_2021_404_MOESM3_ESM.xlsx Hsapiens 2 44448 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [47] "PMC8762874 /pmc/articles/PMC8762874/bin/12860_2021_404_MOESM3_ESM.xlsx Hsapiens 1 44259"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [48] "PMC8762874 /pmc/articles/PMC8762874/bin/12860_2021_404_MOESM3_ESM.xlsx Hsapiens 2 44259 44258"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
##  [49] "PMC8756499 /pmc/articles/PMC8756499/bin/mmc2.xlsx Ggallus 6 44083 44083 44083 44083 44083 44083"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##  [50] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM10_ESM.xlsx Hsapiens 11 44089 44089 44089 44089 44089 43894 43894 43894 43894 43894 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [51] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM10_ESM.xlsx Hsapiens 11 44089 44089 44089 44089 44089 43894 43894 43894 43894 43894 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [52] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM11_ESM.xlsx Hsapiens 10 44089 44089 44089 44089 44089 44089 43894 43894 43894 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [53] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM11_ESM.xlsx Hsapiens 10 44089 44089 44089 44089 44089 44089 43894 43894 43894 43891"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
##  [54] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM12_ESM.xlsx Hsapiens 21 44089 43892 43892 43891 43898 44078 43900 44083 44083 43892 44084 43897 44079 44077 44085 43891 43896 43901 43893 44082 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [55] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM12_ESM.xlsx Hsapiens 21 44089 43892 43892 43891 43898 44078 43900 44083 44083 43892 44084 43897 44079 44077 44085 43891 43896 43901 43893 44082 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
##  [56] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM13_ESM.xlsx Hsapiens 22 44089 43892 43892 43891 43898 44078 43900 43900 44083 44083 44083 43892 44084 44079 44077 44085 43891 43896 43901 43893 44082 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [57] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM13_ESM.xlsx Hsapiens 22 44089 43892 43892 43891 43898 44078 43900 43900 44083 44083 44083 43892 44084 44079 44077 44085 43891 43896 43901 43893 44082 44080"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [58] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM14_ESM.xlsx Hsapiens 2 44085 43901"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [59] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM14_ESM.xlsx Hsapiens 2 44085 43901"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [60] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM15_ESM.xlsx Hsapiens 2 44085 43901"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [61] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM15_ESM.xlsx Hsapiens 2 44085 43901"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
##  [62] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM16_ESM.xlsx Hsapiens 1 44089"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [63] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM16_ESM.xlsx Hsapiens 1 44089"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [64] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM17_ESM.xlsx Hsapiens 1 44089"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [65] "PMC8692330 /pmc/articles/PMC8692330/bin/41467_2021_26901_MOESM17_ESM.xlsx Hsapiens 1 44089"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
##  [66] "PMC8761743 /pmc/articles/PMC8761743/bin/Table_2.xlsx Hsapiens 2 44256 44261"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
##  [67] "PMC8761743 /pmc/articles/PMC8761743/bin/Table_2.xlsx Hsapiens 2 44256 44266"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
##  [68] "PMC8753122 /pmc/articles/PMC8753122/bin/mmc3.xlsx Celegans 184 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043 37043"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
##  [69] "PMC8753122 /pmc/articles/PMC8753122/bin/mmc3.xlsx Celegans 42 38777 37043 38777 38777 37043 38777 38777 37043 38777 38777 37043 38777 37043 37043 38777 38777 37043 38777 37043 38777 37043 38777 38777 38777 37043 38777 38777 37043 38777 38777 38777 38777 37043 38777 38777 38777 37043 38777 37530 37043 38777 38777"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##  [70] "PMC8753122 /pmc/articles/PMC8753122/bin/mmc5.xlsx Celegans 23 38777 36982 37530 38777 36982 37135 36982 37530 37043 38047 37043 37043 37165 38777 38412 38777 37681 38777 38047 38412 37681 38047 37681"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##  [71] "PMC8738961 /pmc/articles/PMC8738961/bin/mmc3.xlsx Hsapiens 2 44447 44448"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
##  [72] "PMC8757482 /pmc/articles/PMC8757482/bin/NIHMS1735652-supplement-3.xlsx Hsapiens 27 44450 44452 44446 44266 44261 44451 44260 44447 44256 44263 44531 44259 44440 44448 44443 44442 44264 44265 44444 4