Source: https://github.com/markziemann/GeneNameErrors2020

View the reports: http://ziemann-lab.net/public/gene_name_errors/

Intro

Gene name errors result when data are imported improperly into MS Excel and other spreadsheet programs (Zeeberg et al, 2004). Certain gene names like MARCH3, SEPT2 and DEC1 are converted into date format. These errors are surprisingly common in supplementary data files in the field of genomics (Ziemann et al, 2016). This could be considered a small error because it only affects a small number of genes, however it is symptomtic of poor data processing methods. The purpose of this script is to identify gene name errors present in supplementary files of PubMed Central articles in the previous month.

library("XML")
library("jsonlite")
library("xml2")
library("reutils")
library("readxl")
library("RCurl")

Get PMC IDs

Here I will be getting PubMed Central IDs for the previous month.

Start with figuring out the date to search PubMed Central.

CURRENT_MONTH=format(Sys.time(), "%m")
CURRENT_YEAR=format(Sys.time(), "%Y")

if (CURRENT_MONTH == "01") {
  PREV_YEAR=as.character(as.numeric(format(Sys.time(), "%Y"))-1)
  PREV_MONTH="12"
} else {
  PREV_YEAR=CURRENT_YEAR
  PREV_MONTH=as.character(as.numeric(format(Sys.time(), "%m"))-1)
}

DATE=paste(PREV_YEAR,"/",PREV_MONTH,sep="")
DATE
## [1] "2023/4"

Let’s see how many PMC IDs we have in the past month.

QUERY ='((genom*[Abstract]))'

ESEARCH_RES <- esearch(term=QUERY, db = "pmc", rettype = "uilist", retmode = "xml", retstart = 0, 
  retmax = 5000000, usehistory = TRUE, webenv = NULL, querykey = NULL, sort = NULL, field = NULL, 
  datetype = NULL, reldate = NULL, 
  mindate = paste(DATE,"/1",sep="") , maxdate = paste(DATE,"/31",sep=""))

pmc <- efetch(ESEARCH_RES,retmode="text",rettype="uilist",outfile="pmcids.txt")
## Retrieving UIDs 1 to 500
## Retrieving UIDs 501 to 1000
## Retrieving UIDs 1001 to 1500
## Retrieving UIDs 1501 to 2000
## Retrieving UIDs 2001 to 2500
## Retrieving UIDs 2501 to 3000
## Retrieving UIDs 3001 to 3500
pmc <- read.table(pmc)
pmc <- paste("PMC",pmc$V1,sep="")
NUM_ARTICLES=length(pmc)
NUM_ARTICLES
## [1] 3359
writeLines(pmc,con="pmc.txt")

Run the screen

Now run the bash script. Note that false positives can occur (~1.5%) and these results have not been verified by a human.

Here are some definitions:

  • NUM_XLS = Number of supplementary Excel files in this set of PMC articles.

  • NUM_XLS_ARTICLES = Number of articles matching the PubMed Central search which have supplementary Excel files.

  • GENELISTS = The gene lists found in the Excel files. Each Excel file is counted once even it has multiple gene lists.

  • NUM_GENELISTS = The number of Excel files with gene lists.

  • NUM_GENELIST_ARTICLES = The number of PMC articles with supplementary Excel gene lists.

  • ERROR_GENELISTS = Files suspected to contain gene name errors. The dates and five-digit numbers indicate transmogrified gene names.

  • NUM_ERROR_GENELISTS = Number of Excel gene lists with errors.

  • NUM_ERROR_GENELIST_ARTICLES = Number of articles with supplementary Excel gene name errors.

  • ERROR_PROPORTION = This is the proportion of articles with Excel gene lists that have errors.

system("./gene_names.sh pmc.txt")
results <- readLines("results.txt")

XLS <- results[grep("XLS",results,ignore.case=TRUE)]
NUM_XLS = length(XLS)
NUM_XLS
## [1] 4944
NUM_XLS_ARTICLES = length(unique(sapply(strsplit(XLS," "),"[[",1)))
NUM_XLS_ARTICLES
## [1] 1157
GENELISTS <- XLS[lapply(strsplit(XLS," "),length)>2]
#GENELISTS

NUM_GENELISTS <- length(unique(sapply(strsplit(GENELISTS," "),"[[",2)))
NUM_GENELISTS
## [1] 567
NUM_GENELIST_ARTICLES <- length(unique(sapply(strsplit(GENELISTS," "),"[[",1)))
NUM_GENELIST_ARTICLES
## [1] 296
ERROR_GENELISTS <- XLS[lapply(strsplit(XLS," "),length)>3]
#ERROR_GENELISTS

NUM_ERROR_GENELISTS = length(ERROR_GENELISTS)
NUM_ERROR_GENELISTS
## [1] 204
GENELIST_ERROR_ARTICLES <- unique(sapply(strsplit(ERROR_GENELISTS," "),"[[",1))
GENELIST_ERROR_ARTICLES
##  [1] "PMC10148045" "PMC10147683" "PMC10146888" "PMC10140479" "PMC10140356"
##  [6] "PMC10140160" "PMC10138339" "PMC10134541" "PMC10134367" "PMC10126422"
## [11] "PMC10124151" "PMC10121420" "PMC10120908" "PMC10119186" "PMC10119024"
## [16] "PMC10104777" "PMC10103417" "PMC10101686" "PMC10101332" "PMC10099834"
## [21] "PMC10098193" "PMC10095438" "PMC10095316" "PMC10092771" "PMC10087516"
## [26] "PMC10086525" "PMC10084920" "PMC10082087" "PMC10080023" "PMC10079878"
## [31] "PMC10078807" "PMC10076939" "PMC10076316" "PMC10073929" "PMC10072823"
## [36] "PMC10070455" "PMC10069891" "PMC10069868" "PMC10067406" "PMC10066595"
## [41] "PMC10066286" "PMC10063665" "PMC10148492" "PMC10146992" "PMC10142227"
## [46] "PMC10141963" "PMC10140399" "PMC10139981" "PMC10132553" "PMC10123121"
## [51] "PMC10120025" "PMC10119396" "PMC10118386" "PMC10115815" "PMC10115646"
## [56] "PMC10108528" "PMC10106861" "PMC10104827" "PMC10103646" "PMC10099689"
## [61] "PMC10097911" "PMC10092010" "PMC10091377" "PMC10087204" "PMC10085592"
## [66] "PMC10082194" "PMC10080956" "PMC10077681" "PMC10071012" "PMC10070495"
## [71] "PMC10067935" "PMC10064647" "PMC10064413"
NUM_ERROR_GENELIST_ARTICLES <- length(GENELIST_ERROR_ARTICLES) 
NUM_ERROR_GENELIST_ARTICLES
## [1] 73
ERROR_PROPORTION = NUM_ERROR_GENELIST_ARTICLES / NUM_GENELIST_ARTICLES
ERROR_PROPORTION
## [1] 0.2466216

Look at the errors detected

Here you can have a look at all the gene lists detected in the past month, as well as those with errors. The dates are obvious errors, these are commonly dates in September, March, December and October. The five-digit numbers represent dates as they are encoded in the Excel internal format. The five digit number is the number of days since 1900. If you were to take these numbers and put them into Excel and format the cells as dates, then these will also mostly map to dates in September, March, December and October.

#GENELISTS

ERROR_GENELISTS
##   [1] "PMC10148045 PMC_DL/PMC10148045/supplementaryfiles/mmc6.xlsx Hsapiens 14 44626 44819 44810 44806 44811 44621 44812 44622 44627 44815 44625 44814 44807 44813"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [2] "PMC10148045 PMC_DL/PMC10148045/supplementaryfiles/mmc4.xlsx Hsapiens 200 45173 45184 45175 45171 45176 44986 45170 45177 44987 45180 44990 45179 45178 45173 45175 45176 44986 45170 45177 44987 45174 45180 44990 45179 45178 45173 44991 45175 45171 45176 44986 45170 45177 44987 45174 45180 45179 45172 45178 44991 45175 45171 45176 44986 45170 45177 44987 45174 45180 44990 45179 45172 45178 45173 45175 45171 45176 44986 45170 45177 44987 45180 44990 45179 45178 45184 45175 45171 45176 44986 45177 44987 45180 44990 45178 45173 45175 45171 45176 44986 45177 45174 45180 45179 45178 45173 45175 45171 45176 45177 45180 45178 45184 45175 45171 45176 44986 45170 45177 44987 45180 44990 45179 45178 45173 45184 45175 45171 45176 44986 45170 45177 45174 45180 45179 45178 45175 45171 45176 44986 45170 45177 44987 45180 45179 45172 45178 45173 45175 45171 45176 45170 45177 44987 45174 45180 45179 45178 45175 45171 45176 44986 45177 44987 45180 44990 45179 45178 45175 45171 45176 44986 45170 45177 44987 45180 45178 45184 45175 45171 45176 44986 45170 45177 44987 45180 44990 45179 45178 45175 45171 45176 45170 45177 45174 45180 44990 45178 45184 45175 45171 45176 44986 45177 44987 45174 45180 45179 45178 44991 45175 45171 45176 45170 45177 45174 45180 44990 45179 45178"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
##   [3] "PMC10148045 PMC_DL/PMC10148045/supplementaryfiles/mmc4.xlsx Hsapiens 1184 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45170 45170 45170 45178 45175 45178 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45176 45175 45170 45178 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45171 45178 45178 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45176 45170 45176 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45170 45176 45178 45175 45175 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45176 45171 45170 45178 45176 45178 45175 45175 45178 45178 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45171 45175 45171 45176 45175 45175 45175 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45176 45175 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45171 45175 45170 45170 45176 45178 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45171 45175 45176 45175 45178 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45175 45176 45178 45175 45175 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45171 45175 45171 45178 45170 45170 45170 45178 45178 45178 45178 45175 45178 45175 45170 45170 45175 45170 45170 45175 45170 45170 45175 45170 45170 45175 45170 45170 45175 45170 45170 45175 45170 45170 45175 45170 45170 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45171 45175 45170 45170 45170 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45175 45170 45170 45170 45176 45175 45175 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45170 45178 45178 45178 45176 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 45171 45171 45171 45171 45175 45177 45170 45178 45175 45175 45178 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175 44995 45170 45170 45170 45178 45178 45176 45178 45175 45175"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##   [4] "PMC10148045 PMC_DL/PMC10148045/supplementaryfiles/mmc4.xlsx Hsapiens 15 44808 44626 44819 44810 44806 44811 44621 44812 44622 44627 44815 44625 44814 44807 44813"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
##   [5] "PMC10148045 PMC_DL/PMC10148045/supplementaryfiles/mmc8.xlsx Hsapiens 14 44621 44622 44625 44805 44814 44815 44806 44807 44808 44809 44810 44811 44812 44813"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
##   [6] "PMC10147683 PMC_DL/PMC10147683/supplementaryfiles/41467_2023_38132_MOESM5_ESM.xlsx Hsapiens 2 39692 40057"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
##   [7] "PMC10147683 PMC_DL/PMC10147683/supplementaryfiles/41467_2023_38132_MOESM4_ESM.xlsx Hsapiens 26 36951 37316 36951 40238 37316 37681 38047 38412 38777 39142 39508 39873 42248 37135 40422 40787 41153 41883 37500 37865 38231 38596 38961 39326 39692 40057"