date generated: 2023-11-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
7SK -3.1559183
A1BG -0.8492416
A1CF -5.5179610
A2LD1 -1.6160879
A2M -1.5724682
A2ML1 -2.5948604

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1654
num_genes_in_profile 33930
duplicated_genes_present 0
num_profile_genes_in_sets 10033
num_profile_genes_not_in_sets 23897

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: c2.cp.reactome.v2023.1.Hs.symbols.gmt
Gene set metrics
Gene sets metrics
num_genesets 1654
num_genesets_excluded 374
num_genesets_included 1280

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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set setSize pANOVA s.dist p.adjustANOVA
REACTOME FORMATION OF LATERAL PLATE MESODERM 5 4.70e-04 0.903 2.30e-03
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 8 1.27e-05 0.891 1.16e-04
REACTOME OLFACTORY SIGNALING PATHWAY 373 0.00e+00 -0.757 0.00e+00
REACTOME BETA DEFENSINS 36 3.73e-14 -0.729 2.17e-12
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS 6 2.18e-03 -0.722 7.96e-03
REACTOME VITAMINS 6 2.86e-03 0.703 9.89e-03
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION 10 1.90e-04 0.681 1.12e-03
REACTOME DEFENSINS 45 8.40e-15 -0.668 5.26e-13
REACTOME ADRENOCEPTORS 9 6.25e-04 0.658 2.87e-03
REACTOME FBXW7 MUTANTS AND NOTCH1 IN CANCER 5 1.23e-02 0.647 3.13e-02
REACTOME G2 PHASE 5 1.44e-02 0.632 3.53e-02
REACTOME INTERLEUKIN 9 SIGNALING 7 5.46e-03 0.606 1.65e-02
REACTOME DEFECTIVE CHST3 CAUSES SEDCJD 7 5.51e-03 0.606 1.66e-02
REACTOME DIGESTION OF DIETARY CARBOHYDRATE 8 3.29e-03 -0.600 1.12e-02
REACTOME DEFECTIVE CHSY1 CAUSES TPBS 7 6.07e-03 0.599 1.80e-02
REACTOME ENDOSOMAL VACUOLAR PATHWAY 9 1.87e-03 0.599 7.03e-03
REACTOME TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 30 1.68e-08 0.595 3.25e-07
REACTOME BIOSYNTHESIS OF MARESIN LIKE SPMS 6 1.17e-02 -0.594 3.02e-02
REACTOME BIOSYNTHESIS OF EPA DERIVED SPMS 6 1.23e-02 0.590 3.13e-02
REACTOME ERKS ARE INACTIVATED 13 2.77e-04 0.582 1.48e-03
REACTOME CD22 MEDIATED BCR REGULATION 53 2.87e-13 -0.579 1.42e-11
REACTOME ANTIMICROBIAL PEPTIDES 86 1.94e-20 -0.577 2.11e-18
REACTOME LIGAND RECEPTOR INTERACTIONS 8 4.77e-03 0.576 1.51e-02
REACTOME RESPONSE TO METAL IONS 14 1.95e-04 0.575 1.14e-03
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS 5 2.78e-02 0.568 5.90e-02
REACTOME REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 11 1.20e-03 0.564 4.85e-03
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 56 3.61e-13 0.561 1.68e-11
REACTOME ERYTHROPOIETIN ACTIVATES STAT5 7 1.06e-02 0.558 2.78e-02
REACTOME CS DS DEGRADATION 12 8.67e-04 0.555 3.76e-03
REACTOME REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.11e-04 0.552 1.20e-03
REACTOME METALLOTHIONEINS BIND METALS 11 1.80e-03 0.543 6.88e-03
REACTOME RHO GTPASES ACTIVATE ROCKS 19 4.34e-05 0.542 3.26e-04
REACTOME SIGNALING BY RNF43 MUTANTS 8 8.90e-03 0.534 2.42e-02
REACTOME LIPID PARTICLE ORGANIZATION 6 2.39e-02 0.532 5.26e-02
REACTOME REGULATION OF FZD BY UBIQUITINATION 21 2.96e-05 0.526 2.37e-04
REACTOME NOSTRIN MEDIATED ENOS TRAFFICKING 5 4.22e-02 0.525 8.24e-02
REACTOME FLT3 SIGNALING BY CBL MUTANTS 7 1.63e-02 0.524 3.93e-02
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 14 6.84e-04 0.524 3.08e-03
REACTOME BETA CATENIN PHOSPHORYLATION CASCADE 16 2.89e-04 0.523 1.54e-03
REACTOME NADE MODULATES DEATH SIGNALLING 5 4.34e-02 0.521 8.40e-02
REACTOME CREATION OF C4 AND C2 ACTIVATORS 63 8.36e-13 -0.521 3.50e-11
REACTOME SUMOYLATION OF TRANSCRIPTION FACTORS 20 5.61e-05 0.520 4.07e-04
REACTOME PROSTANOID LIGAND RECEPTORS 9 6.97e-03 0.519 2.00e-02
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH PI3K 7 1.75e-02 0.519 4.14e-02
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS 10 4.53e-03 0.518 1.44e-02
REACTOME LRR FLII INTERACTING PROTEIN 1 LRRFIP1 ACTIVATES TYPE I IFN PRODUCTION 5 4.49e-02 0.518 8.61e-02
REACTOME SENSORY PERCEPTION 576 7.00e-100 -0.513 5.46e-97
REACTOME DEFECTIVE CHST14 CAUSES EDS MUSCULOCONTRACTURAL TYPE 7 1.88e-02 0.513 4.40e-02
REACTOME SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 14 1.02e-03 0.507 4.30e-03
REACTOME ROLE OF ABL IN ROBO SLIT SIGNALING 8 1.32e-02 0.506 3.31e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME FORMATION OF LATERAL PLATE MESODERM 5 4.70e-04 0.903000 2.30e-03
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 8 1.27e-05 0.891000 1.16e-04
REACTOME OLFACTORY SIGNALING PATHWAY 373 0.00e+00 -0.757000 0.00e+00
REACTOME BETA DEFENSINS 36 3.73e-14 -0.729000 2.17e-12
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS 6 2.18e-03 -0.722000 7.96e-03
REACTOME VITAMINS 6 2.86e-03 0.703000 9.89e-03
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION 10 1.90e-04 0.681000 1.12e-03
REACTOME DEFENSINS 45 8.40e-15 -0.668000 5.26e-13
REACTOME ADRENOCEPTORS 9 6.25e-04 0.658000 2.87e-03
REACTOME FBXW7 MUTANTS AND NOTCH1 IN CANCER 5 1.23e-02 0.647000 3.13e-02
REACTOME G2 PHASE 5 1.44e-02 0.632000 3.53e-02
REACTOME INTERLEUKIN 9 SIGNALING 7 5.46e-03 0.606000 1.65e-02
REACTOME DEFECTIVE CHST3 CAUSES SEDCJD 7 5.51e-03 0.606000 1.66e-02
REACTOME DIGESTION OF DIETARY CARBOHYDRATE 8 3.29e-03 -0.600000 1.12e-02
REACTOME DEFECTIVE CHSY1 CAUSES TPBS 7 6.07e-03 0.599000 1.80e-02
REACTOME ENDOSOMAL VACUOLAR PATHWAY 9 1.87e-03 0.599000 7.03e-03
REACTOME TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 30 1.68e-08 0.595000 3.25e-07
REACTOME BIOSYNTHESIS OF MARESIN LIKE SPMS 6 1.17e-02 -0.594000 3.02e-02
REACTOME BIOSYNTHESIS OF EPA DERIVED SPMS 6 1.23e-02 0.590000 3.13e-02
REACTOME ERKS ARE INACTIVATED 13 2.77e-04 0.582000 1.48e-03
REACTOME CD22 MEDIATED BCR REGULATION 53 2.87e-13 -0.579000 1.42e-11
REACTOME ANTIMICROBIAL PEPTIDES 86 1.94e-20 -0.577000 2.11e-18
REACTOME LIGAND RECEPTOR INTERACTIONS 8 4.77e-03 0.576000 1.51e-02
REACTOME RESPONSE TO METAL IONS 14 1.95e-04 0.575000 1.14e-03
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS 5 2.78e-02 0.568000 5.90e-02
REACTOME REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 11 1.20e-03 0.564000 4.85e-03
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 56 3.61e-13 0.561000 1.68e-11
REACTOME ERYTHROPOIETIN ACTIVATES STAT5 7 1.06e-02 0.558000 2.78e-02
REACTOME CS DS DEGRADATION 12 8.67e-04 0.555000 3.76e-03
REACTOME REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.11e-04 0.552000 1.20e-03
REACTOME METALLOTHIONEINS BIND METALS 11 1.80e-03 0.543000 6.88e-03
REACTOME RHO GTPASES ACTIVATE ROCKS 19 4.34e-05 0.542000 3.26e-04
REACTOME SIGNALING BY RNF43 MUTANTS 8 8.90e-03 0.534000 2.42e-02
REACTOME LIPID PARTICLE ORGANIZATION 6 2.39e-02 0.532000 5.26e-02
REACTOME REGULATION OF FZD BY UBIQUITINATION 21 2.96e-05 0.526000 2.37e-04
REACTOME NOSTRIN MEDIATED ENOS TRAFFICKING 5 4.22e-02 0.525000 8.24e-02
REACTOME FLT3 SIGNALING BY CBL MUTANTS 7 1.63e-02 0.524000 3.93e-02
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 14 6.84e-04 0.524000 3.08e-03
REACTOME BETA CATENIN PHOSPHORYLATION CASCADE 16 2.89e-04 0.523000 1.54e-03
REACTOME NADE MODULATES DEATH SIGNALLING 5 4.34e-02 0.521000 8.40e-02
REACTOME CREATION OF C4 AND C2 ACTIVATORS 63 8.36e-13 -0.521000 3.50e-11
REACTOME SUMOYLATION OF TRANSCRIPTION FACTORS 20 5.61e-05 0.520000 4.07e-04
REACTOME PROSTANOID LIGAND RECEPTORS 9 6.97e-03 0.519000 2.00e-02
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH PI3K 7 1.75e-02 0.519000 4.14e-02
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS 10 4.53e-03 0.518000 1.44e-02
REACTOME LRR FLII INTERACTING PROTEIN 1 LRRFIP1 ACTIVATES TYPE I IFN PRODUCTION 5 4.49e-02 0.518000 8.61e-02
REACTOME SENSORY PERCEPTION 576 7.00e-100 -0.513000 5.46e-97
REACTOME DEFECTIVE CHST14 CAUSES EDS MUSCULOCONTRACTURAL TYPE 7 1.88e-02 0.513000 4.40e-02
REACTOME SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 14 1.02e-03 0.507000 4.30e-03
REACTOME ROLE OF ABL IN ROBO SLIT SIGNALING 8 1.32e-02 0.506000 3.31e-02
REACTOME PP2A MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 6 3.25e-02 0.504000 6.71e-02
REACTOME IKBA VARIANT LEADS TO EDA ID 6 3.28e-02 0.503000 6.76e-02
REACTOME INITIAL TRIGGERING OF COMPLEMENT 70 6.70e-13 -0.496000 2.87e-11
REACTOME SCAVENGING OF HEME FROM PLASMA 60 2.87e-11 -0.496000 9.97e-10
REACTOME REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 9 1.02e-02 0.494000 2.72e-02
REACTOME TACHYKININ RECEPTORS BIND TACHYKININS 5 5.60e-02 0.493000 1.03e-01
REACTOME BINDING OF TCF LEF CTNNB1 TO TARGET GENE PROMOTERS 8 1.57e-02 0.493000 3.82e-02
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 1.40e-04 0.492000 8.83e-04
REACTOME NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY 6 3.73e-02 0.491000 7.50e-02
REACTOME DERMATAN SULFATE BIOSYNTHESIS 10 7.26e-03 0.490000 2.05e-02
REACTOME TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 19 2.40e-04 0.487000 1.31e-03
REACTOME FCGR ACTIVATION 61 7.38e-11 -0.482000 2.36e-09
REACTOME GASTRULATION 48 8.31e-09 0.480000 1.78e-07
REACTOME ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 11 5.81e-03 0.480000 1.73e-02
REACTOME POU5F1 OCT4 SOX2 NANOG ACTIVATE GENES RELATED TO PROLIFERATION 12 4.03e-03 0.479000 1.33e-02
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 24 4.81e-05 0.479000 3.55e-04
REACTOME RHO GTPASES ACTIVATE CIT 19 3.01e-04 0.479000 1.58e-03
REACTOME SMAC XIAP REGULATED APOPTOTIC RESPONSE 6 4.22e-02 0.479000 8.24e-02
REACTOME SMALL INTERFERING RNA SIRNA BIOGENESIS 5 6.59e-02 0.475000 1.18e-01
REACTOME DRUG MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY 5 6.62e-02 0.474000 1.18e-01
REACTOME RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS 5 6.68e-02 0.473000 1.19e-01
REACTOME SIGNALING BY NOTCH1 T 7 9 NOTCH1 M1580 K2555 TRANSLOCATION MUTANT 7 3.05e-02 0.472000 6.38e-02
REACTOME CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 9 1.47e-02 0.470000 3.59e-02
REACTOME MINERALOCORTICOID BIOSYNTHESIS 6 4.70e-02 -0.468000 8.92e-02
REACTOME MAPK3 ERK1 ACTIVATION 10 1.06e-02 0.467000 2.78e-02
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 16 1.25e-03 0.466000 5.03e-03
REACTOME NTRK2 ACTIVATES RAC1 5 7.13e-02 0.466000 1.26e-01
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS 5 7.19e-02 0.465000 1.26e-01
REACTOME FGFRL1 MODULATION OF FGFR1 SIGNALING 13 3.79e-03 0.464000 1.27e-02
REACTOME COHESIN LOADING ONTO CHROMATIN 7 3.40e-02 0.463000 7.00e-02
REACTOME ACTIVATION OF CASPASES THROUGH APOPTOSOME MEDIATED CLEAVAGE 5 7.37e-02 0.462000 1.28e-01
REACTOME VLDLR INTERNALISATION AND DEGRADATION 16 1.47e-03 0.459000 5.76e-03
REACTOME RAF INDEPENDENT MAPK1 3 ACTIVATION 22 2.06e-04 0.457000 1.18e-03
REACTOME NGF STIMULATED TRANSCRIPTION 38 1.08e-06 0.457000 1.39e-05
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 28 3.10e-05 0.455000 2.45e-04
REACTOME WNT LIGAND BIOGENESIS AND TRAFFICKING 25 8.28e-05 0.455000 5.65e-04
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 2.31e-03 0.454000 8.34e-03
REACTOME RELEASE OF HH NP FROM THE SECRETING CELL 8 2.62e-02 0.454000 5.66e-02
REACTOME MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS 7 3.77e-02 0.454000 7.56e-02
REACTOME SIGNALING BY HIPPO 19 6.21e-04 0.453000 2.87e-03
REACTOME CREATINE METABOLISM 10 1.31e-02 0.453000 3.31e-02
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA PLCG 7 3.95e-02 0.449000 7.84e-02
REACTOME REGULATION OF BETA CELL DEVELOPMENT 41 6.68e-07 0.448000 9.15e-06
REACTOME RUNX3 REGULATES NOTCH SIGNALING 13 5.12e-03 0.448000 1.58e-02
REACTOME FORMATION OF AXIAL MESODERM 13 5.13e-03 0.448000 1.58e-02
REACTOME SIGNALING BY WNT IN CANCER 32 1.16e-05 0.448000 1.07e-04
REACTOME DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 30 2.26e-05 0.447000 1.88e-04
REACTOME INACTIVATION OF CDC42 AND RAC1 8 2.87e-02 0.446000 6.04e-02
REACTOME AMINO ACID CONJUGATION 9 2.06e-02 -0.446000 4.72e-02
REACTOME PHYSIOLOGICAL FACTORS 14 3.92e-03 0.445000 1.30e-02
REACTOME ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 19 8.55e-04 0.442000 3.73e-03
REACTOME SUMOYLATION OF IMMUNE RESPONSE PROTEINS 10 1.56e-02 0.442000 3.80e-02
REACTOME SIGNALING BY FGFR4 40 1.42e-06 0.440000 1.71e-05
REACTOME SIGNALING BY LEPTIN 11 1.15e-02 0.440000 2.97e-02
REACTOME ONCOGENE INDUCED SENESCENCE 32 1.67e-05 0.439000 1.45e-04
REACTOME GRB7 EVENTS IN ERBB2 SIGNALING 5 8.90e-02 0.439000 1.48e-01
REACTOME TRANSPORT OF ORGANIC ANIONS 10 1.67e-02 -0.437000 3.98e-02
REACTOME SIGNALING BY MRAS COMPLEX MUTANTS 7 4.55e-02 0.437000 8.70e-02
REACTOME RUNX3 REGULATES YAP1 MEDIATED TRANSCRIPTION 7 4.60e-02 0.435000 8.76e-02
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 7.51e-09 0.435000 1.63e-07
REACTOME SIGNALING BY FGFR4 IN DISEASE 11 1.26e-02 0.434000 3.19e-02
REACTOME TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION 12 9.24e-03 0.434000 2.48e-02
REACTOME NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 9.25e-03 0.434000 2.48e-02
REACTOME DOPAMINE RECEPTORS 5 9.43e-02 0.432000 1.55e-01
REACTOME NEF MEDIATED CD8 DOWN REGULATION 7 4.85e-02 0.431000 9.12e-02
REACTOME ACTIVATION OF RAC1 11 1.34e-02 0.430000 3.35e-02
REACTOME FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 30 4.51e-05 0.430000 3.36e-04
REACTOME SPRY REGULATION OF FGF SIGNALING 16 2.97e-03 0.429000 1.03e-02
REACTOME RUNX3 REGULATES BCL2L11 BIM TRANSCRIPTION 5 9.72e-02 0.428000 1.59e-01
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 11 1.42e-02 0.427000 3.51e-02
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE 5 9.85e-02 0.427000 1.60e-01
REACTOME NEGATIVE REGULATION OF MAPK PATHWAY 41 2.30e-06 0.426000 2.56e-05
REACTOME ALPHA DEFENSINS 9 2.71e-02 -0.425000 5.78e-02
REACTOME CALCITONIN LIKE LIGAND RECEPTORS 10 2.00e-02 0.425000 4.62e-02
REACTOME BETA OXIDATION OF LAUROYL COA TO DECANOYL COA COA 5 1.00e-01 0.425000 1.62e-01
REACTOME PI 3K CASCADE FGFR4 19 1.40e-03 0.423000 5.55e-03
REACTOME MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 12 1.12e-02 0.423000 2.91e-02
REACTOME BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA 6 7.32e-02 0.422000 1.27e-01
REACTOME BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA 5 1.02e-01 0.422000 1.65e-01
REACTOME NEGATIVE REGULATION OF FGFR4 SIGNALING 30 6.42e-05 0.421000 4.53e-04
REACTOME HDACS DEACETYLATE HISTONES 29 8.99e-05 0.420000 6.06e-04
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 15 4.89e-03 0.420000 1.53e-02
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 26 2.15e-04 0.419000 1.21e-03
REACTOME INLA MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS 9 2.95e-02 0.419000 6.18e-02
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR4 14 6.68e-03 0.419000 1.95e-02
REACTOME REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 7 5.54e-02 0.418000 1.02e-01
REACTOME SIGNALING BY FGFR2 IIIA TM 19 1.61e-03 0.418000 6.23e-03
REACTOME SODIUM COUPLED PHOSPHATE COTRANSPORTERS 5 1.06e-01 0.417000 1.70e-01
REACTOME ERK MAPK TARGETS 20 1.26e-03 0.416000 5.09e-03
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE 5 1.07e-01 0.416000 1.71e-01
REACTOME SUMO IS TRANSFERRED FROM E1 TO E2 UBE2I UBC9 7 5.66e-02 0.416000 1.04e-01
REACTOME PROCESSING AND ACTIVATION OF SUMO 10 2.28e-02 0.416000 5.06e-02
REACTOME BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 17 3.09e-03 0.414000 1.07e-02
REACTOME P75NTR SIGNALS VIA NF KB 15 5.56e-03 0.413000 1.67e-02
REACTOME NEGATIVE REGULATION OF FGFR1 SIGNALING 32 5.22e-05 0.413000 3.81e-04
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 19 1.83e-03 0.413000 6.94e-03
REACTOME ACTIVATION OF SMO 17 3.22e-03 0.413000 1.10e-02
REACTOME PI3K AKT ACTIVATION 9 3.22e-02 0.412000 6.66e-02
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 63 1.50e-08 -0.412000 2.94e-07
REACTOME SYNTHESIS OF GDP MANNOSE 5 1.11e-01 0.412000 1.76e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 29 1.24e-04 0.412000 8.09e-04
REACTOME NEGATIVE REGULATION OF FGFR3 SIGNALING 28 1.65e-04 0.411000 9.98e-04
REACTOME PI 3K CASCADE FGFR1 21 1.13e-03 0.410000 4.64e-03
REACTOME DEFECTIVE CHST6 CAUSES MCDC1 8 4.45e-02 0.410000 8.57e-02
REACTOME INHIBITION OF DNA RECOMBINATION AT TELOMERE 19 1.97e-03 0.410000 7.33e-03
REACTOME THE ACTIVATION OF ARYLSULFATASES 8 4.49e-02 0.409000 8.61e-02
REACTOME ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 3.55e-03 0.408000 1.20e-02
REACTOME HIV ELONGATION ARREST AND RECOVERY 25 4.13e-04 0.408000 2.05e-03
REACTOME RAP1 SIGNALLING 16 4.75e-03 0.408000 1.50e-02
REACTOME SIGNALING BY FGFR3 39 1.05e-05 0.408000 9.86e-05
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 24 5.53e-04 0.407000 2.61e-03
REACTOME PI 3K CASCADE FGFR3 17 3.68e-03 0.407000 1.24e-02
REACTOME EPITHELIAL MESENCHYMAL TRANSITION EMT DURING GASTRULATION 6 8.60e-02 0.405000 1.44e-01
REACTOME GERM LAYER FORMATION AT GASTRULATION 16 5.14e-03 0.404000 1.58e-02
REACTOME REPRESSION OF WNT TARGET GENES 13 1.18e-02 0.404000 3.02e-02
REACTOME RHO GTPASES ACTIVATE KTN1 11 2.05e-02 0.403000 4.72e-02
REACTOME MAPK1 ERK2 ACTIVATION 9 3.62e-02 0.403000 7.35e-02
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS 18 3.15e-03 0.402000 1.08e-02
REACTOME NEGATIVE REGULATION OF FGFR2 SIGNALING 33 6.69e-05 0.401000 4.68e-04
REACTOME INTERLEUKIN 15 SIGNALING 13 1.23e-02 0.401000 3.14e-02
REACTOME REGULATION OF PTEN MRNA TRANSLATION 5 1.21e-01 0.400000 1.88e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 1.25e-02 0.400000 3.16e-02
REACTOME SIGNALING BY MAPK MUTANTS 6 8.97e-02 0.400000 1.49e-01
REACTOME DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 38 1.98e-05 0.400000 1.67e-04
REACTOME SIGNALING BY FGFR2 IN DISEASE 42 7.31e-06 0.400000 7.13e-05
REACTOME PEXOPHAGY 11 2.17e-02 0.400000 4.91e-02
REACTOME METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 7.47e-03 0.399000 2.10e-02
REACTOME NEPHRIN FAMILY INTERACTIONS 21 1.59e-03 0.398000 6.16e-03
REACTOME DEFECTIVE GALNT3 CAUSES HFTC 16 5.86e-03 -0.398000 1.75e-02
REACTOME SIGNALING BY FGFR2 72 5.21e-09 0.398000 1.21e-07
REACTOME RMTS METHYLATE HISTONE ARGININES 28 2.73e-04 0.397000 1.47e-03
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 29 2.22e-04 0.396000 1.24e-03
REACTOME PRE NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 6 9.42e-02 0.395000 1.55e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 29 2.36e-04 0.394000 1.30e-03
REACTOME FORMATION OF PARAXIAL MESODERM 21 1.76e-03 0.394000 6.73e-03
REACTOME POLB DEPENDENT LONG PATCH BASE EXCISION REPAIR 7 7.11e-02 0.394000 1.25e-01
REACTOME MELANIN BIOSYNTHESIS 5 1.28e-01 -0.394000 1.97e-01
REACTOME TELOMERE EXTENSION BY TELOMERASE 22 1.40e-03 0.393000 5.55e-03
REACTOME KSRP KHSRP BINDS AND DESTABILIZES MRNA 17 5.00e-03 0.393000 1.56e-02
REACTOME MICRORNA MIRNA BIOGENESIS 21 1.83e-03 0.393000 6.94e-03
REACTOME PI 3K CASCADE FGFR2 22 1.45e-03 0.392000 5.68e-03
REACTOME CYCLIN D ASSOCIATED EVENTS IN G1 46 4.21e-06 0.392000 4.40e-05
REACTOME FGFR2 MUTANT RECEPTOR ACTIVATION 32 1.32e-04 0.390000 8.48e-04
REACTOME ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 72 1.05e-08 -0.390000 2.14e-07
REACTOME RAF ACTIVATION 32 1.36e-04 0.390000 8.68e-04
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 76 4.25e-09 -0.389000 1.02e-07
REACTOME SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 14 1.17e-02 0.389000 3.01e-02
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 89 2.29e-10 0.388000 6.78e-09
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION 57 4.30e-07 0.387000 6.43e-06
REACTOME INTERLEUKIN 6 SIGNALING 11 2.64e-02 0.387000 5.68e-02
REACTOME STAT5 ACTIVATION 7 7.70e-02 0.386000 1.32e-01
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 11 2.67e-02 0.386000 5.73e-02
REACTOME SIGNALING BY ALK IN CANCER 51 1.87e-06 0.386000 2.13e-05
REACTOME APOPTOTIC FACTOR MEDIATED RESPONSE 17 5.93e-03 0.385000 1.76e-02
REACTOME CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.11e-02 0.384000 4.81e-02
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 19 3.72e-03 0.384000 1.25e-02
REACTOME FGFR2 ALTERNATIVE SPLICING 27 5.49e-04 0.384000 2.60e-03
REACTOME G0 AND EARLY G1 27 5.51e-04 0.384000 2.61e-03
REACTOME INTERLEUKIN 36 PATHWAY 7 7.89e-02 -0.383000 1.35e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 31 2.21e-04 0.383000 1.24e-03
REACTOME SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 53 1.40e-06 0.383000 1.71e-05
REACTOME SYNTHESIS OF 15 EICOSATETRAENOIC ACID DERIVATIVES 6 1.05e-01 0.382000 1.69e-01
REACTOME SIGNALING BY FGFR1 49 3.65e-06 0.382000 3.83e-05
REACTOME DIGESTION 19 3.98e-03 -0.382000 1.31e-02
REACTOME DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 27 5.99e-04 0.381000 2.77e-03
REACTOME SYNTHESIS OF DIPHTHAMIDE EEF2 6 1.06e-01 0.381000 1.70e-01
REACTOME DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1 9 4.84e-02 0.380000 9.11e-02
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 9 4.87e-02 0.379000 9.14e-02
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 29 4.06e-04 0.379000 2.03e-03
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 17 6.80e-03 0.379000 1.97e-02
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 32 2.10e-04 0.378000 1.20e-03
REACTOME RUNX3 REGULATES WNT SIGNALING 8 6.39e-02 0.378000 1.15e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 24 1.34e-03 0.378000 5.34e-03
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 166 3.72e-17 0.378000 3.19e-15
REACTOME ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.34e-02 0.378000 5.18e-02
REACTOME DECTIN 2 FAMILY 26 8.84e-04 -0.377000 3.82e-03
REACTOME POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 42 2.50e-05 0.376000 2.04e-04
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 44 1.74e-05 0.374000 1.50e-04
REACTOME CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 4.79e-03 0.374000 1.51e-02
REACTOME DEFECTIVE B4GALT1 CAUSES B4GALT1 CDG CDG 2D 8 6.73e-02 0.374000 1.20e-01
REACTOME BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA 5 1.48e-01 0.373000 2.21e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 28 6.25e-04 0.373000 2.87e-03
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION 15 1.24e-02 0.373000 3.15e-02
REACTOME SIGNALING BY WNT 257 6.35e-25 0.372000 1.03e-22
REACTOME CONSTITUTIVE SIGNALING BY EGFRVIII 15 1.27e-02 0.372000 3.19e-02
REACTOME TOXICITY OF BOTULINUM TOXIN TYPE D BOTD 5 1.50e-01 0.372000 2.23e-01
REACTOME FLT3 SIGNALING IN DISEASE 28 6.73e-04 0.371000 3.05e-03
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 14 1.63e-02 0.371000 3.93e-02
REACTOME HYALURONAN UPTAKE AND DEGRADATION 11 3.33e-02 0.371000 6.84e-02
REACTOME RNA POLYMERASE II TRANSCRIBES SNRNA GENES 73 4.32e-08 0.370000 7.75e-07
REACTOME ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.31e-02 0.369000 8.38e-02
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 47 1.17e-05 0.369000 1.08e-04
REACTOME RHO GTPASES ACTIVATE PAKS 19 5.32e-03 0.369000 1.62e-02
REACTOME ELASTIC FIBRE FORMATION 44 2.24e-05 0.369000 1.87e-04
REACTOME REGULATION OF TP53 EXPRESSION AND DEGRADATION 37 1.06e-04 0.368000 7.08e-04
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX 8 7.13e-02 0.368000 1.26e-01
REACTOME COMPLEMENT CASCADE 104 8.98e-11 -0.368000 2.81e-09
REACTOME DEFECTIVE C1GALT1C1 CAUSES TNPS 16 1.09e-02 -0.367000 2.86e-02
REACTOME NEF MEDIATED CD4 DOWN REGULATION 9 5.63e-02 0.367000 1.04e-01
REACTOME HYALURONAN METABOLISM 15 1.40e-02 0.366000 3.46e-02
REACTOME INTERLEUKIN 7 SIGNALING 21 3.69e-03 0.366000 1.24e-02
REACTOME CHOLINE CATABOLISM 6 1.21e-01 0.366000 1.88e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 12 2.84e-02 0.365000 5.99e-02
REACTOME DIGESTION OF DIETARY LIPID 7 9.43e-02 -0.365000 1.55e-01
REACTOME HATS ACETYLATE HISTONES 65 3.49e-07 0.365000 5.31e-06
REACTOME LYSINE CATABOLISM 10 4.56e-02 0.365000 8.71e-02
REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 2.28e-02 0.365000 5.06e-02
REACTOME TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 17 9.28e-03 0.364000 2.49e-02
REACTOME PROLONGED ERK ACTIVATION EVENTS 14 1.84e-02 0.364000 4.34e-02
REACTOME DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS 25 1.65e-03 0.364000 6.36e-03
REACTOME SIGNALING BY FGFR 85 6.71e-09 0.363000 1.52e-07
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES 12 2.93e-02 0.363000 6.15e-02
REACTOME SIGNALING BY BMP 27 1.09e-03 0.363000 4.56e-03
REACTOME RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 2.64e-03 0.362000 9.28e-03
REACTOME CALCINEURIN ACTIVATES NFAT 9 6.00e-02 0.362000 1.10e-01
REACTOME PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 21 4.11e-03 0.362000 1.34e-02
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS 21 4.16e-03 0.361000 1.35e-02
REACTOME COMPLEX I BIOGENESIS 45 2.76e-05 0.361000 2.21e-04
REACTOME RUNX3 REGULATES P14 ARF 10 4.81e-02 0.361000 9.09e-02
REACTOME LINOLEIC ACID LA METABOLISM 7 9.85e-02 0.361000 1.60e-01
REACTOME ASSEMBLY OF THE HIV VIRION 14 1.95e-02 0.360000 4.53e-02
REACTOME NETRIN MEDIATED REPULSION SIGNALS 8 7.81e-02 0.360000 1.33e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS 12 3.12e-02 0.359000 6.50e-02
REACTOME RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.58e-04 0.359000 9.74e-04
REACTOME SIGNALING BY ERBB2 ECD MUTANTS 15 1.64e-02 0.358000 3.94e-02
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION 12 3.19e-02 0.358000 6.61e-02
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE 29 8.59e-04 0.357000 3.74e-03
REACTOME TELOMERE MAINTENANCE 61 1.41e-06 0.357000 1.71e-05
REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX 28 1.08e-03 0.357000 4.53e-03
REACTOME CA2 PATHWAY 58 2.63e-06 0.356000 2.88e-05
REACTOME DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 81 2.87e-08 0.356000 5.25e-07
REACTOME ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 26 1.66e-03 0.356000 6.38e-03
REACTOME CHROMATIN MODIFYING ENZYMES 171 8.73e-16 0.356000 6.47e-14
REACTOME SIGNALING BY FGFR1 IN DISEASE 37 1.84e-04 0.355000 1.09e-03
REACTOME FORMATION OF APOPTOSOME 10 5.18e-02 0.355000 9.66e-02
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 39 1.27e-04 -0.355000 8.15e-04
REACTOME LGI ADAM INTERACTIONS 14 2.17e-02 0.354000 4.90e-02
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 49 1.79e-05 0.354000 1.52e-04
REACTOME CHOLESTEROL BIOSYNTHESIS 23 3.30e-03 0.354000 1.12e-02
REACTOME SUMOYLATION OF TRANSCRIPTION COFACTORS 42 7.19e-05 0.354000 4.99e-04
REACTOME SIGNALING BY FGFR IN DISEASE 61 1.75e-06 0.354000 2.02e-05
REACTOME TRANSCRIPTIONAL REGULATION BY E2F6 32 5.34e-04 0.354000 2.54e-03
REACTOME CRMPS IN SEMA3A SIGNALING 15 1.77e-02 0.354000 4.19e-02
REACTOME REGULATION OF BACH1 ACTIVITY 11 4.26e-02 0.353000 8.29e-02
REACTOME ENOS ACTIVATION 11 4.26e-02 0.353000 8.29e-02
REACTOME MOLECULES ASSOCIATED WITH ELASTIC FIBRES 37 2.02e-04 0.353000 1.17e-03
REACTOME G BETA GAMMA SIGNALLING THROUGH CDC42 19 7.73e-03 0.353000 2.15e-02
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 1.80e-02 0.353000 4.26e-02
REACTOME RHOT1 GTPASE CYCLE 5 1.72e-01 0.352000 2.48e-01
REACTOME FGFR1C LIGAND BINDING AND ACTIVATION 11 4.33e-02 0.352000 8.39e-02
REACTOME EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 25 2.33e-03 0.352000 8.41e-03
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION 8 8.51e-02 -0.352000 1.43e-01
REACTOME SUMO IS PROTEOLYTICALLY PROCESSED 6 1.36e-01 0.351000 2.07e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.89e-02 0.350000 4.41e-02
REACTOME SIGNALING BY NOTCH1 69 5.37e-07 0.349000 7.82e-06
REACTOME SIGNALING BY NTRK2 TRKB 25 2.55e-03 0.349000 9.04e-03
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE GIP 12 3.67e-02 0.348000 7.42e-02
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 20 7.05e-03 0.348000 2.02e-02
REACTOME MRNA CAPPING 28 1.43e-03 0.348000 5.66e-03
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY 24 3.17e-03 0.348000 1.09e-02
REACTOME RHOV GTPASE CYCLE 36 3.03e-04 0.348000 1.59e-03
REACTOME VIRAL MESSENGER RNA SYNTHESIS 41 1.21e-04 0.347000 7.93e-04
REACTOME PERK REGULATES GENE EXPRESSION 30 1.03e-03 0.346000 4.34e-03
REACTOME PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 9.10e-03 0.346000 2.46e-02
REACTOME HIV TRANSCRIPTION ELONGATION 34 4.88e-04 0.345000 2.38e-03
REACTOME MEIOTIC SYNAPSIS 31 9.07e-04 0.344000 3.90e-03
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 13 3.17e-02 0.344000 6.58e-02
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 36 3.59e-04 0.344000 1.82e-03
REACTOME REGULATION OF PTEN LOCALIZATION 8 9.26e-02 0.343000 1.52e-01
REACTOME CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 10 6.02e-02 0.343000 1.10e-01
REACTOME SIGNALING BY ALK 26 2.48e-03 0.343000 8.84e-03
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 48 3.98e-05 0.343000 3.02e-04
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 17 1.46e-02 0.342000 3.58e-02
REACTOME REGULATED PROTEOLYSIS OF P75NTR 11 4.95e-02 0.342000 9.28e-02
REACTOME RET SIGNALING 40 1.89e-04 0.341000 1.12e-03
REACTOME EPIGENETIC REGULATION OF GENE EXPRESSION 82 9.37e-08 0.341000 1.57e-06
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 48 4.39e-05 0.341000 3.28e-04
REACTOME FRS MEDIATED FGFR4 SIGNALING 21 6.87e-03 0.341000 1.98e-02
REACTOME MODULATION BY MTB OF HOST IMMUNE SYSTEM 6 1.49e-01 0.340000 2.22e-01
REACTOME B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 28 1.84e-03 0.340000 6.94e-03
REACTOME NEGATIVE REGULATION OF FLT3 15 2.26e-02 0.340000 5.04e-02
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 15 2.29e-02 0.339000 5.07e-02
REACTOME CITRIC ACID CYCLE TCA CYCLE 21 7.15e-03 0.339000 2.03e-02
REACTOME KERATAN SULFATE DEGRADATION 13 3.44e-02 0.339000 7.06e-02
REACTOME UNFOLDED PROTEIN RESPONSE UPR 85 6.56e-08 0.339000 1.12e-06
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.90e-02 0.339000 4.44e-02
REACTOME TRANSCRIPTIONAL REGULATION BY SMALL RNAS 42 1.46e-04 0.339000 9.12e-04
REACTOME CHREBP ACTIVATES METABOLIC GENE EXPRESSION 8 9.75e-02 0.338000 1.59e-01
REACTOME MITOTIC TELOPHASE CYTOKINESIS 10 6.43e-02 0.338000 1.15e-01
REACTOME EXTENSION OF TELOMERES 48 5.11e-05 0.338000 3.75e-04
REACTOME FGFR1 MUTANT RECEPTOR ACTIVATION 30 1.37e-03 0.338000 5.45e-03
REACTOME RNA POLYMERASE II TRANSCRIPTION 1233 7.32e-91 0.338000 3.98e-88
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 11 5.26e-02 0.337000 9.79e-02
REACTOME IRE1ALPHA ACTIVATES CHAPERONES 47 6.35e-05 0.337000 4.50e-04
REACTOME FGFR2 LIGAND BINDING AND ACTIVATION 19 1.10e-02 0.337000 2.86e-02
REACTOME FLT3 SIGNALING THROUGH SRC FAMILY KINASES 6 1.53e-01 0.337000 2.27e-01
REACTOME SHC MEDIATED CASCADE FGFR4 19 1.12e-02 0.336000 2.90e-02
REACTOME MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 17 1.64e-02 0.336000 3.94e-02
REACTOME FRS MEDIATED FGFR1 SIGNALING 23 5.26e-03 0.336000 1.61e-02
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 29 1.73e-03 0.336000 6.64e-03
REACTOME MITOCHONDRIAL UNCOUPLING 5 1.94e-01 0.335000 2.72e-01
REACTOME REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 13 3.65e-02 0.335000 7.39e-02
REACTOME STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 6.70e-02 0.334000 1.19e-01
REACTOME CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 25 3.79e-03 0.334000 1.27e-02
REACTOME HEDGEHOG ON STATE 83 1.37e-07 0.334000 2.27e-06
REACTOME SARS COV 1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS 16 2.06e-02 0.334000 4.72e-02
REACTOME SIGNALING BY NTRKS 131 3.74e-11 0.334000 1.24e-09
REACTOME TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 13 3.70e-02 0.334000 7.48e-02
REACTOME TRANSCRIPTIONAL REGULATION BY MECP2 56 1.54e-05 0.334000 1.35e-04
REACTOME ESTROGEN DEPENDENT GENE EXPRESSION 83 1.48e-07 0.333000 2.41e-06
REACTOME SENSING OF DNA DOUBLE STRAND BREAKS 5 1.97e-01 0.333000 2.75e-01
REACTOME SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 2.10e-02 0.333000 4.80e-02
REACTOME NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 19 1.21e-02 0.332000 3.09e-02
REACTOME ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 5 1.98e-01 0.332000 2.76e-01
REACTOME REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 6.90e-02 0.332000 1.22e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 25 4.10e-03 0.332000 1.34e-02
REACTOME SHC MEDIATED CASCADE FGFR1 21 8.52e-03 0.332000 2.33e-02
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION 22 7.11e-03 0.331000 2.02e-02
REACTOME FCERI MEDIATED CA 2 MOBILIZATION 77 4.85e-07 -0.331000 7.13e-06
REACTOME NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 24 4.95e-03 0.331000 1.55e-02
REACTOME MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 15 2.64e-02 0.331000 5.68e-02
REACTOME MYOCLONIC EPILEPSY OF LAFORA 9 8.60e-02 0.330000 1.44e-01
REACTOME RHOC GTPASE CYCLE 67 2.92e-06 0.330000 3.12e-05
REACTOME STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING 9 8.64e-02 0.330000 1.45e-01
REACTOME SYNTHESIS OF UDP N ACETYL GLUCOSAMINE 7 1.31e-01 0.330000 2.00e-01
REACTOME NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 21 8.96e-03 0.329000 2.43e-02
REACTOME RHOU GTPASE CYCLE 37 5.23e-04 0.329000 2.51e-03
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 7.14e-02 0.329000 1.26e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION INITIATION 42 2.27e-04 0.329000 1.26e-03
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 30 1.83e-03 0.329000 6.94e-03
REACTOME CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 10 7.19e-02 0.329000 1.26e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION 45 1.38e-04 0.328000 8.76e-04
REACTOME SEMAPHORIN INTERACTIONS 61 9.30e-06 0.328000 8.91e-05
REACTOME SUMOYLATION OF DNA REPLICATION PROTEINS 43 1.97e-04 0.328000 1.15e-03
REACTOME PKMTS METHYLATE HISTONE LYSINES 32 1.33e-03 0.328000 5.33e-03
REACTOME TRNA PROCESSING IN THE NUCLEUS 53 3.66e-05 0.328000 2.82e-04
REACTOME SIGNAL AMPLIFICATION 33 1.12e-03 0.328000 4.64e-03
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH RAS 9 8.90e-02 0.327000 1.48e-01
REACTOME SUMOYLATION 162 6.28e-13 0.327000 2.77e-11
REACTOME DNA DOUBLE STRAND BREAK RESPONSE 39 4.13e-04 0.327000 2.05e-03
REACTOME RHOB GTPASE CYCLE 64 6.11e-06 0.327000 6.23e-05
REACTOME TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 10 7.40e-02 0.326000 1.28e-01
REACTOME MRNA SPLICING 192 5.70e-15 0.326000 3.87e-13
REACTOME REGULATION OF NPAS4 MRNA TRANSLATION 5 2.07e-01 0.326000 2.85e-01
REACTOME RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 10 7.44e-02 0.326000 1.28e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 3.49e-02 0.326000 7.12e-02
REACTOME CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 24 5.80e-03 0.325000 1.73e-02
REACTOME SIGNALING BY NOTCH4 79 5.86e-07 0.325000 8.45e-06
REACTOME NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 44 1.95e-04 0.324000 1.14e-03
REACTOME CHROMOSOME MAINTENANCE 81 4.37e-07 0.324000 6.48e-06
REACTOME REGULATION OF MECP2 EXPRESSION AND ACTIVITY 26 4.19e-03 0.324000 1.35e-02
REACTOME SIGNALING BY ACTIVIN 15 2.97e-02 0.324000 6.21e-02
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 36 7.72e-04 0.324000 3.44e-03
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 11 6.32e-02 0.323000 1.14e-01
REACTOME SIGNALING BY TGFB FAMILY MEMBERS 119 1.07e-09 0.323000 2.85e-08
REACTOME LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 1.48e-02 0.323000 3.62e-02
REACTOME SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 8 1.14e-01 0.323000 1.79e-01
REACTOME RNA POLYMERASE II TRANSCRIPTION TERMINATION 63 9.22e-06 0.323000 8.90e-05
REACTOME PTEN REGULATION 128 2.69e-10 0.323000 7.82e-09
REACTOME EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 30 2.23e-03 0.322000 8.09e-03
REACTOME FRS MEDIATED FGFR2 SIGNALING 24 6.23e-03 0.322000 1.84e-02
REACTOME TELOMERE C STRAND SYNTHESIS INITIATION 11 6.41e-02 0.322000 1.15e-01
REACTOME RHOF GTPASE CYCLE 39 4.99e-04 0.322000 2.42e-03
REACTOME RNA POLYMERASE II PRE TRANSCRIPTION EVENTS 67 5.20e-06 0.322000 5.37e-05
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH CDK5 6 1.73e-01 0.321000 2.49e-01
REACTOME REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 71 2.93e-06 0.321000 3.12e-05
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 255 1.21e-18 0.320000 1.16e-16
REACTOME SUMO IS CONJUGATED TO E1 UBA2 SAE1 5 2.16e-01 0.319000 2.93e-01
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21 58 2.57e-05 0.319000 2.08e-04
REACTOME TRANSCRIPTION OF THE HIV GENOME 57 3.04e-05 0.319000 2.42e-04
REACTOME RHO GTPASES ACTIVATE PKNS 33 1.51e-03 0.319000 5.88e-03
REACTOME INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 18 1.94e-02 0.318000 4.50e-02
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 14 3.93e-02 0.318000 7.83e-02
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 91 1.57e-07 0.318000 2.51e-06
REACTOME ETHANOL OXIDATION 12 5.70e-02 0.317000 1.05e-01
REACTOME FRS MEDIATED FGFR3 SIGNALING 19 1.67e-02 0.317000 3.98e-02
REACTOME INACTIVATION OF CSF3 G CSF SIGNALING 23 8.45e-03 0.317000 2.32e-02
REACTOME FGFR2B LIGAND BINDING AND ACTIVATION 10 8.27e-02 0.317000 1.40e-01
REACTOME LDL CLEARANCE 19 1.69e-02 0.316000 4.03e-02
REACTOME HDMS DEMETHYLATE HISTONES 16 2.85e-02 0.316000 6.00e-02
REACTOME SUPPRESSION OF APOPTOSIS 7 1.47e-01 0.316000 2.20e-01
REACTOME RHOBTB1 GTPASE CYCLE 22 1.03e-02 0.316000 2.72e-02
REACTOME DISEASES ASSOCIATED WITH SURFACTANT METABOLISM 9 1.01e-01 0.316000 1.63e-01
REACTOME P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 6 1.81e-01 0.315000 2.58e-01
REACTOME REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 7.15e-05 0.315000 4.98e-04
REACTOME SUMOYLATION OF SUMOYLATION PROTEINS 32 2.03e-03 0.315000 7.52e-03
REACTOME RECEPTOR MEDIATED MITOPHAGY 10 8.46e-02 0.315000 1.43e-01
REACTOME ESR MEDIATED SIGNALING 153 1.72e-11 0.315000 6.22e-10
REACTOME EPHRIN SIGNALING 17 2.47e-02 0.314000 5.42e-02
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 22 1.07e-02 0.314000 2.82e-02
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 76 2.17e-06 0.314000 2.44e-05
REACTOME RNA POLYMERASE III CHAIN ELONGATION 18 2.11e-02 0.314000 4.81e-02
REACTOME RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 3.44e-03 0.314000 1.17e-02
REACTOME SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 49 1.44e-04 0.314000 9.04e-04
REACTOME DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15 8 1.24e-01 0.314000 1.92e-01
REACTOME NEUROFASCIN INTERACTIONS 6 1.83e-01 0.314000 2.60e-01
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 409 8.95e-28 0.313000 2.08e-25
REACTOME MASTL FACILITATES MITOTIC PROGRESSION 10 8.61e-02 0.313000 1.44e-01
REACTOME REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 51 1.07e-04 0.313000 7.11e-04
REACTOME BASE EXCISION REPAIR AP SITE FORMATION 17 2.54e-02 0.313000 5.53e-02
REACTOME HIV TRANSCRIPTION INITIATION 42 4.49e-04 0.313000 2.21e-03
REACTOME INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 18 2.16e-02 0.313000 4.90e-02
REACTOME DNA DAMAGE RECOGNITION IN GG NER 36 1.16e-03 0.313000 4.74e-03
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH PI3K 6 1.86e-01 0.312000 2.64e-01
REACTOME INTERLEUKIN 27 SIGNALING 11 7.34e-02 0.312000 1.27e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 15 3.66e-02 0.312000 7.41e-02
REACTOME RHOBTB GTPASE CYCLE 34 1.66e-03 0.312000 6.39e-03
REACTOME BETA CATENIN INDEPENDENT WNT SIGNALING 140 1.90e-10 0.311000 5.72e-09
REACTOME TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 53 8.87e-05 0.311000 6.00e-04
REACTOME INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA 11 7.41e-02 -0.311000 1.28e-01
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 12 6.24e-02 0.311000 1.13e-01
REACTOME EPH EPHRIN SIGNALING 89 4.14e-07 0.310000 6.25e-06
REACTOME SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 70 7.11e-06 0.310000 6.98e-05
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 29 3.83e-03 0.310000 1.28e-02
REACTOME TERMINAL PATHWAY OF COMPLEMENT 8 1.29e-01 -0.310000 1.98e-01
REACTOME FCGR3A MEDIATED IL10 SYNTHESIS 86 6.55e-07 -0.310000 9.13e-06
REACTOME CELLULAR RESPONSE TO HYPOXIA 71 6.22e-06 0.310000 6.24e-05
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 46 2.75e-04 0.310000 1.48e-03
REACTOME ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.43e-05 0.310000 1.99e-04
REACTOME REGULATION OF TP53 ACTIVITY 151 4.91e-11 0.309000 1.60e-09
REACTOME SHC MEDIATED CASCADE FGFR3 17 2.72e-02 0.309000 5.80e-02
REACTOME SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 17 2.74e-02 0.309000 5.82e-02
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX2 116 9.22e-09 0.308000 1.90e-07
REACTOME CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 83 1.17e-06 0.308000 1.46e-05
REACTOME NPAS4 REGULATES EXPRESSION OF TARGET GENES 20 1.70e-02 0.308000 4.05e-02
REACTOME FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 8 1.31e-01 -0.308000 2.01e-01
REACTOME GP1B IX V ACTIVATION SIGNALLING 11 7.70e-02 0.308000 1.32e-01
REACTOME MITOPHAGY 25 7.70e-03 0.308000 2.15e-02
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS 10 9.20e-02 0.308000 1.52e-01
REACTOME UCH PROTEINASES 81 1.69e-06 0.307000 1.97e-05
REACTOME COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 38 1.05e-03 0.307000 4.40e-03
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 9.72e-07 0.307000 1.26e-05
REACTOME SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 7 1.60e-01 0.307000 2.35e-01
REACTOME SUMOYLATION OF UBIQUITINYLATION PROTEINS 36 1.45e-03 0.307000 5.68e-03
REACTOME DISEASES OF PROGRAMMED CELL DEATH 42 5.87e-04 0.306000 2.73e-03
REACTOME TELOMERE C STRAND LAGGING STRAND SYNTHESIS 32 2.71e-03 0.306000 9.50e-03
REACTOME ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 28 5.04e-03 0.306000 1.56e-02
REACTOME PROCESSING OF INTRONLESS PRE MRNAS 19 2.10e-02 0.306000 4.80e-02
REACTOME SIGNALING BY NOTCH3 47 2.91e-04 0.305000 1.55e-03
REACTOME MAPK6 MAPK4 SIGNALING 85 1.13e-06 0.305000 1.43e-05
REACTOME BUDDING AND MATURATION OF HIV VIRION 26 7.08e-03 0.305000 2.02e-02
REACTOME FCERI MEDIATED MAPK ACTIVATION 79 2.72e-06 -0.305000 2.96e-05
REACTOME CONDENSATION OF PROMETAPHASE CHROMOSOMES 11 8.00e-02 0.305000 1.36e-01
REACTOME BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 89 6.61e-07 -0.305000 9.13e-06
REACTOME SIGNALING BY CSF3 G CSF 28 5.27e-03 0.305000 1.61e-02
REACTOME DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 5.23e-05 0.304000 3.81e-04
REACTOME CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 25 8.45e-03 0.304000 2.32e-02
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE 62 3.40e-05 0.304000 2.66e-04
REACTOME EICOSANOID LIGAND BINDING RECEPTORS 14 4.87e-02 0.304000 9.14e-02
REACTOME HDR THROUGH SINGLE STRAND ANNEALING SSA 35 1.84e-03 0.304000 6.94e-03
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 79 2.95e-06 0.304000 3.12e-05
REACTOME RUNX2 REGULATES BONE DEVELOPMENT 29 4.60e-03 0.304000 1.46e-02
REACTOME CONJUGATION OF BENZOATE WITH GLYCINE 6 1.97e-01 -0.304000 2.75e-01
REACTOME MIRO GTPASE CYCLE 8 1.37e-01 0.304000 2.07e-01
REACTOME LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 11 8.13e-02 0.304000 1.38e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 19 2.21e-02 0.303000 4.95e-02
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 3.58e-02 0.303000 7.28e-02
REACTOME NEGATIVE REGULATION OF NOTCH4 SIGNALING 52 1.57e-04 0.303000 9.71e-04
REACTOME SIGNALING BY RETINOIC ACID 41 7.91e-04 0.303000 3.49e-03
REACTOME DEX H BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 7 1.65e-01 0.303000 2.40e-01
REACTOME DNA DAMAGE BYPASS 44 5.14e-04 0.302000 2.48e-03
REACTOME DEFECTIVE CSF2RB CAUSES SMDP5 7 1.66e-01 0.302000 2.41e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1 164 2.18e-11 0.302000 7.72e-10
REACTOME CELLULAR SENESCENCE 123 6.81e-09 0.302000 1.52e-07
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 7.01e-02 0.302000 1.24e-01
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 91 6.29e-07 0.302000 9.00e-06
REACTOME G1 S DNA DAMAGE CHECKPOINTS 65 2.56e-05 0.302000 2.08e-04
REACTOME SIGNALING BY FLT3 FUSION PROTEINS 19 2.30e-02 0.301000 5.08e-02
REACTOME ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 39 1.14e-03 0.301000 4.66e-03
REACTOME SIGNAL TRANSDUCTION BY L1 20 1.97e-02 0.301000 4.57e-02
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 9 1.18e-01 0.301000 1.84e-01
REACTOME IRS MEDIATED SIGNALLING 47 3.58e-04 0.301000 1.82e-03
REACTOME PLATELET SENSITIZATION BY LDL 16 3.73e-02 0.301000 7.50e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT 86 1.50e-06 0.300000 1.80e-05
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX3 92 6.53e-07 0.300000 9.13e-06
REACTOME NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 11 8.52e-02 0.300000 1.43e-01
REACTOME G PROTEIN ACTIVATION 24 1.10e-02 0.300000 2.87e-02
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 2.16e-03 0.299000 7.92e-03
REACTOME FASL CD95L SIGNALING 5 2.47e-01 0.299000 3.27e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN 69 1.70e-05 0.299000 1.47e-04
REACTOME TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 7.28e-02 0.299000 1.27e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 9.75e-03 0.299000 2.61e-02
REACTOME KERATINIZATION 215 4.15e-14 -0.298000 2.33e-12
REACTOME SYNTHESIS OF PC 27 7.29e-03 0.298000 2.06e-02
REACTOME TRANSCRIPTIONAL REGULATION BY TP53 327 1.42e-20 0.298000 1.79e-18
REACTOME DARPP 32 EVENTS 24 1.15e-02 0.298000 2.97e-02
REACTOME CREB3 FACTORS ACTIVATE GENES 7 1.72e-01 0.298000 2.48e-01
REACTOME TRANSCRIPTIONAL REGULATION BY NPAS4 28 6.40e-03 0.298000 1.88e-02
REACTOME HCMV LATE EVENTS 49 3.12e-04 0.298000 1.63e-03
REACTOME ERYTHROPOIETIN ACTIVATES RAS 14 5.39e-02 0.297000 1.00e-01
REACTOME HIV LIFE CYCLE 131 4.13e-09 0.297000 1.02e-07
REACTOME MITOTIC G1 PHASE AND G1 S TRANSITION 144 7.57e-10 0.297000 2.09e-08
REACTOME SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 52 2.19e-04 0.296000 1.23e-03
REACTOME OPSINS 7 1.75e-01 -0.296000 2.51e-01
REACTOME RHO GTPASES ACTIVATE WASPS AND WAVES 34 2.84e-03 0.296000 9.87e-03
REACTOME CIRCADIAN CLOCK 65 3.72e-05 0.296000 2.86e-04
REACTOME SIGNALING BY KIT IN DISEASE 20 2.21e-02 0.296000 4.95e-02
REACTOME INTERLEUKIN 17 SIGNALING 66 3.28e-05 0.295000 2.59e-04
REACTOME GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 42 9.29e-04 0.295000 3.97e-03
REACTOME NUCLEOTIDE EXCISION REPAIR 106 1.49e-07 0.295000 2.41e-06
REACTOME POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 24 1.23e-02 0.295000 3.14e-02
REACTOME LYSOSPHINGOLIPID AND LPA RECEPTORS 9 1.26e-01 0.294000 1.95e-01
REACTOME RESOLUTION OF ABASIC SITES AP SITES 37 1.95e-03 0.294000 7.28e-03
REACTOME FOLDING OF ACTIN BY CCT TRIC 10 1.07e-01 0.294000 1.71e-01
REACTOME MEIOSIS 55 1.60e-04 0.294000 9.79e-04
REACTOME CELLULAR RESPONSE TO HEAT STRESS 94 8.58e-07 0.293000 1.17e-05
REACTOME CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 60 8.48e-05 0.293000 5.76e-04
REACTOME REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 9.77e-06 0.293000 9.31e-05
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FYN 7 1.79e-01 0.293000 2.56e-01
REACTOME COBALAMIN CBL METABOLISM 6 2.14e-01 0.293000 2.92e-01
REACTOME ORGANIC ANION TRANSPORTERS 10 1.09e-01 0.293000 1.73e-01
REACTOME SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 53 2.22e-04 0.293000 1.24e-03
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 7.28e-03 0.293000 2.06e-02
REACTOME LAGGING STRAND SYNTHESIS 19 2.71e-02 0.293000 5.78e-02
REACTOME BASE EXCISION REPAIR 44 7.71e-04 0.293000 3.44e-03
REACTOME WNT MEDIATED ACTIVATION OF DVL 8 1.51e-01 0.293000 2.24e-01
REACTOME ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS 5 2.57e-01 0.293000 3.39e-01
REACTOME SYNTHESIS OF DOLICHYL PHOSPHATE 6 2.14e-01 0.293000 2.92e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT 51 2.97e-04 0.293000 1.57e-03
REACTOME HEDGEHOG LIGAND BIOGENESIS 63 5.85e-05 0.293000 4.19e-04
REACTOME PROTEIN FOLDING 94 9.43e-07 0.292000 1.23e-05
REACTOME SIGNALING BY NUCLEAR RECEPTORS 226 3.22e-14 0.292000 1.94e-12
REACTOME SIGNALING BY PDGFR IN DISEASE 20 2.36e-02 0.292000 5.21e-02
REACTOME PCP CE PATHWAY 90 1.63e-06 0.292000 1.93e-05
REACTOME VITAMIN B1 THIAMIN METABOLISM 5 2.58e-01 0.292000 3.39e-01
REACTOME ATTENUATION PHASE 27 8.62e-03 0.292000 2.36e-02
REACTOME ACETYLCHOLINE REGULATES INSULIN SECRETION 10 1.10e-01 0.292000 1.75e-01
REACTOME PINK1 PRKN MEDIATED MITOPHAGY 19 2.77e-02 0.292000 5.87e-02
REACTOME MITOTIC PROPHASE 76 1.08e-05 0.292000 1.01e-04
REACTOME STABILIZATION OF P53 54 2.08e-04 0.292000 1.20e-03
REACTOME KERATAN SULFATE BIOSYNTHESIS 27 8.76e-03 0.291000 2.39e-02
REACTOME TRNA PROCESSING 91 1.63e-06 0.291000 1.93e-05
REACTOME RECYCLING OF EIF2 GDP 7 1.83e-01 0.290000 2.60e-01
REACTOME SUMOYLATION OF RNA BINDING PROTEINS 44 8.53e-04 0.290000 3.73e-03
REACTOME DNA REPAIR 265 3.58e-16 0.290000 2.78e-14
REACTOME PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 57 1.51e-04 0.290000 9.45e-04
REACTOME KERATAN SULFATE KERATIN METABOLISM 33 3.95e-03 0.290000 1.31e-02
REACTOME ER QUALITY CONTROL COMPARTMENT ERQC 20 2.49e-02 0.290000 5.45e-02
REACTOME RIP MEDIATED NFKB ACTIVATION VIA ZBP1 16 4.49e-02 0.290000 8.61e-02
REACTOME ESTABLISHMENT OF SISTER CHROMATID COHESION 8 1.56e-01 0.290000 2.30e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 1.41e-02 0.289000 3.48e-02
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS 9 1.33e-01 0.289000 2.03e-01
REACTOME HOMOLOGY DIRECTED REPAIR 96 9.43e-07 0.289000 1.23e-05
REACTOME TRANSLESION SYNTHESIS BY POLH 17 3.89e-02 0.289000 7.75e-02
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 7.03e-03 0.289000 2.01e-02
REACTOME DNA DOUBLE STRAND BREAK REPAIR 126 2.05e-08 0.289000 3.88e-07
REACTOME HSF1 DEPENDENT TRANSACTIVATION 37 2.36e-03 0.289000 8.47e-03
REACTOME DIGESTION AND ABSORPTION 24 1.43e-02 -0.289000 3.53e-02
REACTOME MET ACTIVATES PI3K AKT SIGNALING 6 2.21e-01 0.289000 2.98e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 41 1.40e-03 0.288000 5.55e-03
REACTOME SIGNALING BY ERYTHROPOIETIN 25 1.27e-02 0.288000 3.19e-02
REACTOME HEME BIOSYNTHESIS 13 7.24e-02 0.288000 1.26e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES 32 4.90e-03 0.287000 1.53e-02
REACTOME GABA RECEPTOR ACTIVATION 57 1.79e-04 0.287000 1.07e-03
REACTOME AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 9 1.37e-01 0.286000 2.07e-01
REACTOME SURFACTANT METABOLISM 27 1.00e-02 0.286000 2.67e-02
REACTOME TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 75 1.81e-05 0.286000 1.54e-04
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 8.79e-03 0.286000 2.39e-02
REACTOME HUR ELAVL1 BINDS AND STABILIZES MRNA 8 1.61e-01 0.286000 2.36e-01
REACTOME CALNEXIN CALRETICULIN CYCLE 25 1.33e-02 0.286000 3.34e-02
REACTOME REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 1.01e-01 0.286000 1.63e-01
REACTOME RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 45 9.20e-04 0.285000 3.95e-03
REACTOME SOS MEDIATED SIGNALLING 7 1.91e-01 0.285000 2.69e-01
REACTOME POLYMERASE SWITCHING 13 7.50e-02 0.285000 1.29e-01
REACTOME SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 8.72e-02 0.285000 1.46e-01
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 14 6.47e-02 0.285000 1.16e-01
REACTOME SIGNALING BY NTRK3 TRKC 16 4.84e-02 0.285000 9.11e-02
REACTOME DEGRADATION OF GLI1 BY THE PROTEASOME 58 1.74e-04 0.285000 1.04e-03
REACTOME FLT3 SIGNALING 38 2.37e-03 0.285000 8.49e-03
REACTOME REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 86 4.90e-06 0.285000 5.09e-05
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 53 3.38e-04 0.284000 1.74e-03
REACTOME DEGRADATION OF AXIN 53 3.42e-04 0.284000 1.76e-03
REACTOME MRNA SPLICING MINOR PATHWAY 48 6.57e-04 0.284000 2.98e-03
REACTOME FGFR1B LIGAND BINDING AND ACTIVATION 6 2.28e-01 0.284000 3.07e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 34 4.17e-03 0.284000 1.35e-02
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 66 6.63e-05 0.284000 4.66e-04
REACTOME FORMATION OF TC NER PRE INCISION COMPLEX 50 5.19e-04 0.284000 2.49e-03
REACTOME GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 81 1.01e-05 0.284000 9.50e-05
REACTOME FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 11 1.03e-01 0.284000 1.66e-01
REACTOME AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 3.56e-04 0.283000 1.82e-03
REACTOME GLYCOSAMINOGLYCAN METABOLISM 115 1.49e-07 0.283000 2.41e-06
REACTOME MET RECEPTOR ACTIVATION 6 2.30e-01 -0.283000 3.09e-01
REACTOME INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 34 4.26e-03 0.283000 1.37e-02
REACTOME REGULATION OF TLR BY ENDOGENOUS LIGAND 20 2.84e-02 -0.283000 6.00e-02
REACTOME SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 7.75e-02 0.283000 1.32e-01
REACTOME DNA REPLICATION INITIATION 7 1.95e-01 0.283000 2.73e-01
REACTOME TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 8.40e-03 0.283000 2.31e-02
REACTOME VITAMIN C ASCORBATE METABOLISM 8 1.66e-01 0.283000 2.41e-01
REACTOME NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 24 1.65e-02 0.283000 3.96e-02
REACTOME BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 10 1.22e-01 0.282000 1.89e-01
REACTOME MITOCHONDRIAL TRANSLATION 92 2.91e-06 0.282000 3.12e-05
REACTOME PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1 9 1.43e-01 0.282000 2.16e-01
REACTOME UB SPECIFIC PROCESSING PROTEASES 151 2.23e-09 0.282000 5.78e-08
REACTOME GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 14 6.82e-02 0.281000 1.21e-01
REACTOME NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER 18 3.87e-02 0.281000 7.72e-02
REACTOME DUAL INCISION IN TC NER 62 1.26e-04 0.281000 8.15e-04
REACTOME EPH EPHRIN MEDIATED REPULSION OF CELLS 50 5.81e-04 0.281000 2.71e-03
REACTOME REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 14 6.87e-02 0.281000 1.22e-01
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 49 6.81e-04 0.280000 3.07e-03
REACTOME REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 3.95e-02 0.280000 7.84e-02
REACTOME THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 137 1.42e-08 0.280000 2.81e-07
REACTOME COPI MEDIATED ANTEROGRADE TRANSPORT 101 1.11e-06 0.280000 1.41e-05
REACTOME INOSITOL PHOSPHATE METABOLISM 45 1.14e-03 0.280000 4.68e-03
REACTOME MYD88 INDEPENDENT TLR4 CASCADE 103 9.07e-07 0.280000 1.21e-05
REACTOME HSF1 ACTIVATION 29 9.22e-03 0.279000 2.48e-02
REACTOME TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 35 4.24e-03 0.279000 1.36e-02
REACTOME EPHB MEDIATED FORWARD SIGNALING 40 2.25e-03 0.279000 8.16e-03
REACTOME HIV INFECTION 208 3.67e-12 0.279000 1.43e-10
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 10 1.27e-01 0.279000 1.96e-01
REACTOME REGULATION OF NF KAPPA B SIGNALING 17 4.69e-02 0.278000 8.92e-02
REACTOME DEUBIQUITINATION 220 1.04e-12 0.278000 4.22e-11
REACTOME PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 2.74e-02 0.278000 5.82e-02
REACTOME VEGFR2 MEDIATED CELL PROLIFERATION 19 3.60e-02 0.278000 7.32e-02
REACTOME COPII MEDIATED VESICLE TRANSPORT 65 1.07e-04 0.278000 7.11e-04
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 1.42e-02 0.278000 3.51e-02
REACTOME INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 14 7.21e-02 0.278000 1.26e-01
REACTOME SIGNALING BY EGFR 49 7.72e-04 0.278000 3.44e-03
REACTOME SIGNALING BY NOTCH2 31 7.52e-03 0.277000 2.11e-02
REACTOME MATURATION OF SARS COV 2 NUCLEOPROTEIN 15 6.33e-02 0.277000 1.14e-01
REACTOME NUCLEAR IMPORT OF REV PROTEIN 31 7.68e-03 0.277000 2.15e-02
REACTOME RHO GTPASES ACTIVATE FORMINS 128 6.42e-08 0.276000 1.12e-06
REACTOME BIOSYNTHESIS OF MARESINS 8 1.76e-01 -0.276000 2.52e-01
REACTOME G ALPHA 12 13 SIGNALLING EVENTS 74 3.97e-05 0.276000 3.02e-04
REACTOME NUCLEAR PORE COMPLEX NPC DISASSEMBLY 33 6.05e-03 0.276000 1.79e-02
REACTOME RUNX3 REGULATES CDKN1A TRANSCRIPTION 7 2.06e-01 0.276000 2.84e-01
REACTOME SIGNALING BY HEDGEHOG 146 8.52e-09 0.276000 1.79e-07
REACTOME TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 36 4.20e-03 0.276000 1.35e-02
REACTOME NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 1.14e-01 0.275000 1.79e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 18 4.34e-02 0.275000 8.39e-02
REACTOME SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 8 1.78e-01 0.275000 2.55e-01
REACTOME FGFR3 LIGAND BINDING AND ACTIVATION 12 9.94e-02 0.275000 1.61e-01
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION 7 2.09e-01 0.274000 2.87e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION 41 2.37e-03 0.274000 8.49e-03
REACTOME MUCOPOLYSACCHARIDOSES 10 1.34e-01 0.274000 2.04e-01
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 65 1.33e-04 0.274000 8.50e-04
REACTOME METABOLISM OF RNA 640 1.24e-32 0.274000 4.03e-30
REACTOME RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 22 2.62e-02 0.274000 5.66e-02
REACTOME TOLL LIKE RECEPTOR 9 TLR9 CASCADE 99 2.50e-06 0.274000 2.75e-05
REACTOME PROCESSING OF SMDT1 10 1.35e-01 0.273000 2.05e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 20 3.46e-02 0.273000 7.08e-02
REACTOME TRANSLESION SYNTHESIS BY POLK 17 5.14e-02 0.273000 9.59e-02
REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 9 1.57e-01 0.273000 2.31e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 1.12e-02 0.272000 2.90e-02
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 16 5.94e-02 0.272000 1.09e-01
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 13 8.93e-02 0.272000 1.49e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 52 7.09e-04 0.271000 3.18e-03
REACTOME APOPTOTIC EXECUTION PHASE 43 2.08e-03 0.271000 7.69e-03
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 171 9.65e-10 -0.271000 2.62e-08
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 4.14e-02 0.270000 8.14e-02
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS 6 2.52e-01 0.270000 3.33e-01
REACTOME ARMS MEDIATED ACTIVATION 7 2.16e-01 0.270000 2.93e-01
REACTOME ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS 7 2.16e-01 0.270000 2.93e-01
REACTOME SUMOYLATION OF DNA METHYLATION PROTEINS 16 6.19e-02 0.270000 1.12e-01
REACTOME APOPTOSIS 164 2.42e-09 0.270000 6.17e-08
REACTOME PHASE 4 RESTING MEMBRANE POTENTIAL 19 4.19e-02 0.270000 8.21e-02
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS 7 2.17e-01 0.269000 2.94e-01
REACTOME REGULATION OF PTEN STABILITY AND ACTIVITY 66 1.55e-04 0.269000 9.63e-04
REACTOME CARNITINE METABOLISM 13 9.31e-02 0.269000 1.53e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 8.15e-02 0.269000 1.38e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 38 4.15e-03 0.269000 1.35e-02
REACTOME ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 20 3.75e-02 0.269000 7.53e-02
REACTOME REGULATION OF NPAS4 GENE EXPRESSION 9 1.64e-01 0.268000 2.40e-01
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 9.98e-03 0.267000 2.66e-02
REACTOME CLATHRIN MEDIATED ENDOCYTOSIS 137 6.54e-08 0.267000 1.12e-06
REACTOME S PHASE 156 8.55e-09 0.267000 1.79e-07
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 19 4.42e-02 0.267000 8.52e-02
REACTOME IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 17 5.70e-02 0.267000 1.05e-01
REACTOME EXTRA NUCLEAR ESTROGEN SIGNALING 74 7.28e-05 0.267000 5.03e-04
REACTOME CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 19 4.43e-02 0.266000 8.53e-02
REACTOME RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA 5 3.02e-01 0.266000 3.85e-01
REACTOME TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 40 3.54e-03 0.266000 1.20e-02
REACTOME HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND 55 6.32e-04 0.266000 2.89e-03
REACTOME POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 25 2.13e-02 0.266000 4.83e-02
REACTOME DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 14 8.50e-02 0.266000 1.43e-01
REACTOME DNA REPLICATION 123 3.48e-07 0.266000 5.31e-06
REACTOME SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 26 1.90e-02 0.266000 4.44e-02
REACTOME SHC RELATED EVENTS TRIGGERED BY IGF1R 9 1.68e-01 0.266000 2.42e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 22 3.13e-02 0.265000 6.50e-02
REACTOME RHOJ GTPASE CYCLE 50 1.19e-03 0.265000 4.83e-03
REACTOME SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 89 1.54e-05 0.265000 1.35e-04
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 37 5.29e-03 0.265000 1.62e-02
REACTOME SIGNAL ATTENUATION 10 1.47e-01 0.265000 2.20e-01
REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 1.28e-01 0.265000 1.98e-01
REACTOME SIGNALING BY ERBB2 IN CANCER 25 2.20e-02 0.264000 4.95e-02
REACTOME HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 64 2.55e-04 0.264000 1.38e-03
REACTOME PLASMA LIPOPROTEIN CLEARANCE 37 5.43e-03 0.264000 1.65e-02
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 51 1.11e-03 0.264000 4.59e-03
REACTOME ER TO GOLGI ANTEROGRADE TRANSPORT 151 2.15e-08 0.264000 4.02e-07
REACTOME GLYCOGEN METABOLISM 22 3.23e-02 0.264000 6.68e-02
REACTOME GPER1 SIGNALING 44 2.49e-03 0.263000 8.88e-03
REACTOME HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 3.94e-03 0.263000 1.31e-02
REACTOME SYNTHESIS OF DNA 117 8.74e-07 0.263000 1.18e-05
REACTOME GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 2.29e-02 0.263000 5.07e-02
REACTOME DISEASES OF MITOTIC CELL CYCLE 36 6.38e-03 0.263000 1.88e-02
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE 5 3.10e-01 -0.262000 3.93e-01
REACTOME NUCLEOTIDE BIOSYNTHESIS 12 1.16e-01 0.262000 1.81e-01
REACTOME MAPK FAMILY SIGNALING CASCADES 306 2.45e-15 0.262000 1.74e-13
REACTOME PREGNENOLONE BIOSYNTHESIS 10 1.51e-01 0.262000 2.24e-01
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 6.19e-05 0.262000 4.41e-04
REACTOME DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 19 4.80e-02 0.262000 9.07e-02
REACTOME ONCOGENIC MAPK SIGNALING 76 7.74e-05 0.262000 5.32e-04
REACTOME TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 47 1.88e-03 0.262000 7.05e-03
REACTOME MET RECEPTOR RECYCLING 10 1.51e-01 0.262000 2.24e-01
REACTOME DISINHIBITION OF SNARE FORMATION 5 3.10e-01 0.262000 3.93e-01
REACTOME HCMV INFECTION 91 1.57e-05 0.262000 1.37e-04
REACTOME CELL CYCLE 588 1.17e-27 0.262000 2.39e-25
REACTOME DEGRADATION OF DVL 55 7.89e-04 0.262000 3.49e-03
REACTOME PRC2 METHYLATES HISTONES AND DNA 12 1.18e-01 0.260000 1.84e-01
REACTOME GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION 7 2.33e-01 0.260000 3.13e-01
REACTOME INTERLEUKIN 35 SIGNALLING 12 1.19e-01 0.260000 1.85e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 45 2.62e-03 0.259000 9.23e-03
REACTOME SIGNALING BY PTK6 54 9.85e-04 0.259000 4.17e-03
REACTOME PHENYLALANINE METABOLISM 5 3.17e-01 0.259000 3.99e-01
REACTOME GLUCOCORTICOID BIOSYNTHESIS 10 1.57e-01 -0.259000 2.31e-01
REACTOME CELL CYCLE CHECKPOINTS 238 6.03e-12 0.258000 2.23e-10
REACTOME FANCONI ANEMIA PATHWAY 33 1.02e-02 0.258000 2.72e-02
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 53 1.16e-03 0.258000 4.74e-03
REACTOME G2 M CHECKPOINTS 125 6.35e-07 0.258000 9.00e-06
REACTOME CELL CYCLE MITOTIC 468 8.67e-22 0.258000 1.18e-19
REACTOME TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION 41 4.38e-03 0.257000 1.40e-02
REACTOME ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 10 1.59e-01 0.257000 2.34e-01
REACTOME G1 S SPECIFIC TRANSCRIPTION 28 1.87e-02 0.257000 4.40e-02
REACTOME TRANSPORT OF NUCLEOTIDE SUGARS 8 2.09e-01 0.256000 2.87e-01
REACTOME NGF INDEPENDANT TRKA ACTIVATION 5 3.21e-01 0.256000 4.04e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 1.41e-01 0.256000 2.13e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX IN CANCER 8 2.10e-01 0.256000 2.87e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 16 7.62e-02 0.256000 1.31e-01
REACTOME INTRACELLULAR SIGNALING BY SECOND MESSENGERS 291 5.06e-14 0.256000 2.75e-12
REACTOME ORGANIC ANION TRANSPORT 5 3.22e-01 -0.256000 4.05e-01
REACTOME AMINO ACIDS REGULATE MTORC1 48 2.17e-03 0.256000 7.93e-03
REACTOME TERMINATION OF TRANSLESION DNA SYNTHESIS 31 1.37e-02 0.256000 3.41e-02
REACTOME RHOQ GTPASE CYCLE 57 8.38e-04 0.256000 3.68e-03
REACTOME GLYCOGEN SYNTHESIS 13 1.11e-01 0.255000 1.76e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS 121 1.20e-06 0.255000 1.49e-05
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 4.74e-03 0.255000 1.50e-02
REACTOME INTRA GOLGI TRAFFIC 42 4.27e-03 0.255000 1.37e-02
REACTOME MISMATCH REPAIR 15 8.77e-02 0.255000 1.47e-01
REACTOME RNA POLYMERASE I PROMOTER ESCAPE 27 2.20e-02 0.255000 4.95e-02
REACTOME RNA POLYMERASE I TRANSCRIPTION TERMINATION 26 2.47e-02 0.254000 5.40e-02
REACTOME RND2 GTPASE CYCLE 40 5.40e-03 0.254000 1.64e-02
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 40 5.46e-03 0.254000 1.65e-02
REACTOME SIGNALING BY NOTCH 176 6.10e-09 0.254000 1.40e-07
REACTOME CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 98 1.44e-05 0.253000 1.29e-04
REACTOME SENSORY PERCEPTION OF SALTY TASTE 6 2.83e-01 -0.253000 3.65e-01
REACTOME TYPE I HEMIDESMOSOME ASSEMBLY 11 1.46e-01 -0.253000 2.19e-01
REACTOME FATTY ACIDS 15 9.00e-02 -0.253000 1.49e-01
REACTOME REGULATION OF RAS BY GAPS 66 3.83e-04 0.253000 1.92e-03
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 50 2.00e-03 0.253000 7.42e-03
REACTOME MTORC1 MEDIATED SIGNALLING 21 4.52e-02 0.252000 8.65e-02
REACTOME HORMONE LIGAND BINDING RECEPTORS 12 1.30e-01 -0.252000 2.00e-01
REACTOME RHOBTB2 GTPASE CYCLE 22 4.07e-02 0.252000 8.04e-02
REACTOME SIGNALLING TO ERKS 34 1.10e-02 0.252000 2.86e-02
REACTOME IRAK4 DEFICIENCY TLR2 4 17 7.21e-02 -0.252000 1.26e-01
REACTOME MITOTIC METAPHASE AND ANAPHASE 216 1.72e-10 0.252000 5.28e-09
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION 9 1.92e-01 0.251000 2.69e-01
REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 7.28e-02 0.251000 1.27e-01
REACTOME REGULATION OF IFNA IFNB SIGNALING 26 2.68e-02 -0.251000 5.73e-02
REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV 1 INFECTION 5 3.31e-01 0.251000 4.15e-01
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 16 8.24e-02 0.251000 1.40e-01
REACTOME PROTEIN UBIQUITINATION 58 9.49e-04 0.251000 4.04e-03
REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS 23 3.74e-02 -0.251000 7.51e-02
REACTOME DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 7.84e-04 0.251000 3.48e-03
REACTOME MITOTIC SPINDLE CHECKPOINT 101 1.33e-05 0.250000 1.21e-04
REACTOME M PHASE 328 6.13e-15 0.250000 4.00e-13
REACTOME CARGO CONCENTRATION IN THE ER 31 1.61e-02 0.250000 3.89e-02
REACTOME SARS COV 2 MODULATES AUTOPHAGY 11 1.52e-01 0.249000 2.25e-01
REACTOME NOD1 2 SIGNALING PATHWAY 33 1.31e-02 0.249000 3.31e-02
REACTOME HEDGEHOG OFF STATE 110 6.17e-06 0.249000 6.24e-05
REACTOME INTERLEUKIN 6 FAMILY SIGNALING 24 3.45e-02 0.249000 7.08e-02
REACTOME NETRIN 1 SIGNALING 48 2.81e-03 0.249000 9.79e-03
REACTOME DEADENYLATION OF MRNA 21 4.82e-02 0.249000 9.09e-02
REACTOME TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 33 1.34e-02 0.249000 3.35e-02
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 32 1.50e-02 0.248000 3.67e-02
REACTOME DISEASES OF BASE EXCISION REPAIR 5 3.37e-01 0.248000 4.20e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 14 1.08e-01 0.248000 1.73e-01
REACTOME SPHINGOLIPID METABOLISM 78 1.54e-04 0.248000 9.57e-04
REACTOME GLUCAGON TYPE LIGAND RECEPTORS 32 1.53e-02 0.248000 3.73e-02
REACTOME KEAP1 NFE2L2 PATHWAY 102 1.53e-05 0.248000 1.35e-04
REACTOME HCMV EARLY EVENTS 69 3.75e-04 0.247000 1.88e-03
REACTOME ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 42 5.51e-03 0.247000 1.66e-02
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 606 2.31e-25 0.246000 4.18e-23
REACTOME TRNA AMINOACYLATION 24 3.71e-02 0.246000 7.49e-02
REACTOME DNA REPLICATION PRE INITIATION 95 3.44e-05 0.246000 2.68e-04
REACTOME G PROTEIN BETA GAMMA SIGNALLING 30 1.98e-02 0.246000 4.57e-02
REACTOME ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA 9 2.02e-01 0.246000 2.80e-01
REACTOME SEPARATION OF SISTER CHROMATIDS 174 2.17e-08 0.246000 4.02e-07
REACTOME RESOLUTION OF SISTER CHROMATID COHESION 112 7.07e-06 0.245000 6.98e-05
REACTOME RHO GTPASE EFFECTORS 245 3.44e-11 0.245000 1.17e-09
REACTOME DUAL INCISION IN GG NER 39 8.04e-03 0.245000 2.23e-02
REACTOME GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 32 1.64e-02 0.245000 3.94e-02
REACTOME NS1 MEDIATED EFFECTS ON HOST PATHWAYS 38 8.98e-03 0.245000 2.44e-02
REACTOME TIE2 SIGNALING 18 7.22e-02 0.245000 1.26e-01
REACTOME DISEASES OF DNA REPAIR 48 3.37e-03 0.245000 1.15e-02
REACTOME HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS 9 2.04e-01 -0.245000 2.82e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.52e-02 0.244000 5.50e-02
REACTOME CROSSLINKING OF COLLAGEN FIBRILS 16 9.07e-02 0.244000 1.50e-01
REACTOME TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 34 1.37e-02 0.244000 3.41e-02
REACTOME JOSEPHIN DOMAIN DUBS 10 1.82e-01 0.244000 2.59e-01
REACTOME CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 1.61e-01 0.244000 2.36e-01
REACTOME HDR THROUGH MMEJ ALT NHEJ 11 1.61e-01 0.244000 2.36e-01
REACTOME CHL1 INTERACTIONS 9 2.05e-01 0.244000 2.84e-01
REACTOME SIGNALING BY INSULIN RECEPTOR 80 1.63e-04 0.244000 9.93e-04
REACTOME FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 1.84e-01 0.242000 2.61e-01
REACTOME ESTROGEN BIOSYNTHESIS 6 3.04e-01 0.242000 3.87e-01
REACTOME DEFECTS IN COBALAMIN B12 METABOLISM 12 1.47e-01 0.242000 2.20e-01
REACTOME SEROTONIN RECEPTORS 11 1.65e-01 0.242000 2.40e-01
REACTOME CELLULAR RESPONSES TO STIMULI 695 8.51e-28 0.242000 2.08e-25
REACTOME VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 42 6.73e-03 0.242000 1.96e-02
REACTOME ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 9 2.09e-01 0.242000 2.87e-01
REACTOME O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 1.34e-02 0.241000 3.35e-02
REACTOME EGFR DOWNREGULATION 30 2.21e-02 0.241000 4.95e-02
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 288 1.62e-12 0.241000 6.43e-11
REACTOME PTK6 REGULATES CELL CYCLE 6 3.06e-01 0.241000 3.89e-01
REACTOME SIGNALING BY ROBO RECEPTORS 202 3.41e-09 0.241000 8.54e-08
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 30 2.28e-02 0.240000 5.06e-02
REACTOME IRON UPTAKE AND TRANSPORT 56 1.87e-03 0.240000 7.04e-03
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 42 7.17e-03 0.240000 2.03e-02
REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES 507 1.67e-20 0.240000 1.94e-18
REACTOME ABC TRANSPORTER DISORDERS 75 3.37e-04 0.239000 1.74e-03
REACTOME GLYCOSPHINGOLIPID METABOLISM 37 1.18e-02 0.239000 3.02e-02
REACTOME HDL REMODELING 10 1.90e-01 0.239000 2.68e-01
REACTOME RHOD GTPASE CYCLE 48 4.16e-03 0.239000 1.35e-02
REACTOME GENE SILENCING BY RNA 73 4.18e-04 0.239000 2.07e-03
REACTOME FATTY ACIDS BOUND TO GPR40 FFAR1 REGULATE INSULIN SECRETION 8 2.43e-01 0.238000 3.23e-01
REACTOME ATORVASTATIN ADME 9 2.16e-01 -0.238000 2.93e-01
REACTOME WAX AND PLASMALOGEN BIOSYNTHESIS 5 3.57e-01 0.238000 4.40e-01
REACTOME RAC2 GTPASE CYCLE 80 2.30e-04 0.238000 1.28e-03
REACTOME RHO GTPASE CYCLE 411 1.02e-16 0.238000 8.28e-15
REACTOME G2 M DNA DAMAGE CHECKPOINT 54 2.51e-03 0.238000 8.91e-03
REACTOME PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 1.24e-01 0.238000 1.92e-01
REACTOME NEDDYLATION 228 6.59e-10 0.237000 1.85e-08
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 1.12e-01 0.237000 1.78e-01
REACTOME REGULATION OF LIPID METABOLISM BY PPARALPHA 113 1.38e-05 0.237000 1.24e-04
REACTOME OTHER INTERLEUKIN SIGNALING 22 5.49e-02 0.236000 1.02e-01
REACTOME SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 4.08e-02 0.236000 8.04e-02
REACTOME OPIOID SIGNALLING 88 1.26e-04 0.236000 8.15e-04
REACTOME NUCLEAR EVENTS MEDIATED BY NFE2L2 76 3.67e-04 0.236000 1.85e-03
REACTOME GLUTAMATE AND GLUTAMINE METABOLISM 11 1.75e-01 0.236000 2.52e-01
REACTOME NUCLEAR ENVELOPE BREAKDOWN 49 4.28e-03 0.236000 1.37e-02
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE 11 1.76e-01 0.236000 2.52e-01
REACTOME MEMBRANE TRAFFICKING 592 7.10e-23 0.236000 1.05e-20
REACTOME SENSORY PERCEPTION OF TASTE 47 5.23e-03 -0.235000 1.61e-02
REACTOME TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 29 2.83e-02 0.235000 5.99e-02
REACTOME INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 196 1.28e-08 0.235000 2.59e-07
REACTOME AUTOPHAGY 135 2.31e-06 0.235000 2.56e-05
REACTOME IRAK1 RECRUITS IKK COMPLEX 12 1.59e-01 0.235000 2.33e-01
REACTOME TBC RABGAPS 41 9.24e-03 0.235000 2.48e-02
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 50 4.07e-03 0.235000 1.34e-02
REACTOME MITOCHONDRIAL BIOGENESIS 65 1.06e-03 0.235000 4.45e-03
REACTOME SIGNALING BY ERBB4 57 2.19e-03 0.234000 7.98e-03
REACTOME INTERLEUKIN 1 SIGNALING 109 2.35e-05 0.234000 1.95e-04
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 73 5.37e-04 0.234000 2.55e-03
REACTOME PROGRAMMED CELL DEATH 194 1.79e-08 0.234000 3.43e-07
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 15 1.17e-01 0.234000 1.83e-01
REACTOME SMOOTH MUSCLE CONTRACTION 40 1.04e-02 0.234000 2.76e-02
REACTOME PI5P REGULATES TP53 ACETYLATION 8 2.53e-01 0.234000 3.34e-01
REACTOME ASPIRIN ADME 43 8.03e-03 -0.234000 2.23e-02
REACTOME FOXO MEDIATED TRANSCRIPTION 64 1.24e-03 0.233000 5.00e-03
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 294 5.15e-12 0.233000 1.95e-10
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 1.85e-02 0.233000 4.36e-02
REACTOME REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 82 2.67e-04 0.233000 1.44e-03
REACTOME NUCLEAR ENVELOPE NE REASSEMBLY 72 6.38e-04 0.233000 2.91e-03
REACTOME SIGNALING BY ERBB2 49 4.84e-03 0.233000 1.52e-02
REACTOME HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS 7 2.87e-01 0.232000 3.69e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 20 7.22e-02 0.232000 1.26e-01
REACTOME RAC3 GTPASE CYCLE 84 2.36e-04 0.232000 1.30e-03
REACTOME SUMOYLATION OF INTRACELLULAR RECEPTORS 29 3.08e-02 0.232000 6.42e-02
REACTOME REGULATION OF KIT SIGNALING 16 1.09e-01 0.231000 1.74e-01
REACTOME REGULATION OF SIGNALING BY CBL 22 6.07e-02 0.231000 1.11e-01
REACTOME E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 41 1.05e-02 0.231000 2.77e-02
REACTOME PROTEIN LOCALIZATION 144 1.67e-06 0.231000 1.96e-05
REACTOME MEIOTIC RECOMBINATION 25 4.57e-02 0.231000 8.71e-02
REACTOME LATE ENDOSOMAL MICROAUTOPHAGY 31 2.62e-02 0.231000 5.66e-02
REACTOME SIGNALING BY NODAL 22 6.13e-02 0.230000 1.12e-01
REACTOME SULFUR AMINO ACID METABOLISM 27 3.82e-02 0.230000 7.64e-02
REACTOME RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 52 4.05e-03 0.230000 1.33e-02
REACTOME TNF SIGNALING 52 4.06e-03 0.230000 1.34e-02
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 89 1.74e-04 0.230000 1.04e-03
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 20 7.49e-02 0.230000 1.29e-01
REACTOME MITOTIC PROMETAPHASE 184 7.28e-08 0.230000 1.24e-06
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 14 1.37e-01 0.230000 2.07e-01
REACTOME DOWNREGULATION OF ERBB4 SIGNALING 9 2.33e-01 0.230000 3.13e-01
REACTOME RORA ACTIVATES GENE EXPRESSION 16 1.12e-01 0.229000 1.77e-01
REACTOME NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 2.09e-01 0.229000 2.87e-01
REACTOME UBIQUINOL BIOSYNTHESIS 8 2.61e-01 0.229000 3.42e-01
REACTOME NONHOMOLOGOUS END JOINING NHEJ 29 3.25e-02 0.229000 6.71e-02
REACTOME SIGNALING BY VEGF 103 5.86e-05 0.229000 4.19e-04
REACTOME RAB GEFS EXCHANGE GTP FOR GDP ON RABS 78 4.70e-04 0.229000 2.30e-03
REACTOMEMATURATION OF SARS COV 1 NUCLEOPROTEIN 11 1.89e-01 0.229000 2.67e-01
REACTOME SELECTIVE AUTOPHAGY 76 5.62e-04 0.229000 2.64e-03
REACTOME ACYL CHAIN REMODELLING OF PI 16 1.13e-01 -0.229000 1.79e-01
REACTOME OVARIAN TUMOR DOMAIN PROTEASES 35 1.93e-02 0.228000 4.48e-02
REACTOME NONCANONICAL ACTIVATION OF NOTCH3 8 2.63e-01 0.228000 3.44e-01
REACTOME SNRNP ASSEMBLY 50 5.24e-03 0.228000 1.61e-02
REACTOME MITOTIC G2 G2 M PHASES 190 5.85e-08 0.228000 1.04e-06
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 71 8.99e-04 0.228000 3.88e-03
REACTOME INWARDLY RECTIFYING K CHANNELS 35 1.97e-02 0.228000 4.57e-02
REACTOME COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 32 2.59e-02 0.227000 5.62e-02
REACTOME FATTY ACYL COA BIOSYNTHESIS 32 2.59e-02 0.227000 5.62e-02
REACTOME TRAF6 MEDIATED NF KB ACTIVATION 23 5.92e-02 0.227000 1.08e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 1.92e-01 0.227000 2.70e-01
REACTOME RND3 GTPASE CYCLE 41 1.19e-02 0.227000 3.05e-02
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS 9 2.39e-01 0.227000 3.19e-01
REACTOME GOLGI TO ER RETROGRADE TRANSPORT 132 6.68e-06 0.227000 6.64e-05
REACTOME NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 2.43e-02 0.227000 5.32e-02
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 77 5.90e-04 0.226000 2.74e-03
REACTOME DNA STRAND ELONGATION 31 2.92e-02 0.226000 6.14e-02
REACTOME LAMININ INTERACTIONS 28 3.84e-02 0.226000 7.67e-02
REACTOME TLR3 MEDIATED TICAM1 DEPENDENT PROGRAMMED CELL DEATH 6 3.38e-01 0.226000 4.21e-01
REACTOME 2 LTR CIRCLE FORMATION 7 3.01e-01 0.226000 3.84e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 353 2.98e-13 0.225000 1.43e-11
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 182 1.58e-07 0.225000 2.51e-06
REACTOME PI3K AKT SIGNALING IN CANCER 103 8.20e-05 0.224000 5.62e-04
REACTOME RAB REGULATION OF TRAFFICKING 108 5.64e-05 0.224000 4.07e-04
REACTOME APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 85 3.59e-04 0.224000 1.82e-03
REACTOME ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.34e-01 0.224000 2.04e-01
REACTOME REGULATION BY C FLIP 11 1.99e-01 0.224000 2.77e-01
REACTOME TNFR1 INDUCED PROAPOPTOTIC SIGNALING 23 6.40e-02 0.223000 1.15e-01
REACTOME SIGNALING BY CSF1 M CSF IN MYELOID CELLS 30 3.48e-02 0.223000 7.12e-02
REACTOME PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 6 3.46e-01 0.222000 4.29e-01
REACTOME LYSOSOME VESICLE BIOGENESIS 33 2.73e-02 0.222000 5.82e-02
REACTOME SIGNALING BY BRAF AND RAF1 FUSIONS 61 2.83e-03 0.221000 9.85e-03
REACTOME SIGNALING BY LRP5 MUTANTS 6 3.49e-01 0.221000 4.32e-01
REACTOME P38MAPK EVENTS 13 1.68e-01 0.221000 2.43e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 1257 2.02e-40 0.221000 8.25e-38
REACTOME SARS COV 1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES 35 2.41e-02 0.220000 5.30e-02
REACTOME G ALPHA Z SIGNALLING EVENTS 48 8.33e-03 0.220000 2.30e-02
REACTOME MTOR SIGNALLING 38 1.90e-02 0.220000 4.44e-02
REACTOME GLYCOLYSIS 66 2.01e-03 0.220000 7.43e-03
REACTOME PTK6 PROMOTES HIF1A STABILIZATION 6 3.52e-01 -0.219000 4.35e-01
REACTOME APEX1 INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY 7 3.15e-01 0.219000 3.97e-01
REACTOME REGULATION OF EXPRESSION OF SLITS AND ROBOS 158 2.11e-06 0.218000 2.39e-05
REACTOME TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 70 1.59e-03 0.218000 6.16e-03
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 29 4.20e-02 -0.218000 8.21e-02
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 59 3.77e-03 0.218000 1.26e-02
REACTOME NERVOUS SYSTEM DEVELOPMENT 543 3.05e-18 0.217000 2.77e-16
REACTOME TRANSCRIPTIONAL REGULATION BY VENTX 37 2.21e-02 0.217000 4.95e-02
REACTOME SIGNALLING TO RAS 20 9.23e-02 0.217000 1.52e-01
REACTOME COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 52 6.67e-03 0.217000 1.95e-02
REACTOME DEATH RECEPTOR SIGNALING 141 8.29e-06 0.217000 8.04e-05
REACTOME ACTIVATION OF TRKA RECEPTORS 6 3.57e-01 0.217000 4.41e-01
REACTOME SIGNALING BY SCF KIT 43 1.39e-02 0.217000 3.46e-02
REACTOME AURKA ACTIVATION BY TPX2 67 2.16e-03 0.217000 7.92e-03
REACTOME INTERLEUKIN 2 SIGNALING 11 2.14e-01 0.216000 2.92e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 69 1.89e-03 0.216000 7.05e-03
REACTOME SARS COV 2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS 12 1.95e-01 0.216000 2.73e-01
REACTOME SIGNALING BY EGFR IN CANCER 25 6.15e-02 0.216000 1.12e-01
REACTOME SIGNALING BY MEMBRANE TETHERED FUSIONS OF PDGFRA OR PDGFRB 5 4.03e-01 0.216000 4.88e-01
REACTOME TIGHT JUNCTION INTERACTIONS 27 5.23e-02 0.216000 9.75e-02
REACTOME TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 1.14e-01 0.215000 1.79e-01
REACTOME RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 16 1.37e-01 0.215000 2.07e-01
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 21 8.93e-02 0.214000 1.49e-01
REACTOME RHOH GTPASE CYCLE 35 2.84e-02 0.214000 5.99e-02
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 25 6.42e-02 0.214000 1.15e-01
REACTOME UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES 9 2.67e-01 -0.214000 3.48e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE 8 2.96e-01 0.213000 3.79e-01
REACTOME FGFR3B LIGAND BINDING AND ACTIVATION 7 3.29e-01 0.213000 4.12e-01
REACTOME METABOLISM OF CARBOHYDRATES 269 1.70e-09 0.213000 4.47e-08
REACTOME RIPK1 MEDIATED REGULATED NECROSIS 29 4.73e-02 0.213000 8.97e-02
REACTOME SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA PHE 6 3.67e-01 0.213000 4.50e-01
REACTOME PLATELET HOMEOSTASIS 81 9.32e-04 0.213000 3.97e-03
REACTOME METABOLISM OF POLYAMINES 53 7.40e-03 0.213000 2.08e-02
REACTOME CTLA4 INHIBITORY SIGNALING 21 9.20e-02 0.212000 1.52e-01
REACTOME PREVENTION OF PHAGOSOMAL LYSOSOMAL FUSION 9 2.70e-01 0.212000 3.51e-01
REACTOME NEGATIVE REGULATION OF MET ACTIVITY 20 1.01e-01 0.212000 1.63e-01
REACTOME PTK6 EXPRESSION 5 4.12e-01 0.212000 4.94e-01
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS 16 1.43e-01 0.212000 2.15e-01
REACTOME METALLOPROTEASE DUBS 16 1.43e-01 0.211000 2.15e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.32e-02 0.211000 3.32e-02
REACTOME CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 16 1.44e-01 0.211000 2.16e-01
REACTOME THE NLRP3 INFLAMMASOME 16 1.45e-01 0.210000 2.18e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 8.05e-03 0.210000 2.23e-02
REACTOME TRANSLATION 262 4.24e-09 0.210000 1.02e-07
REACTOME GABA B RECEPTOR ACTIVATION 43 1.71e-02 0.210000 4.07e-02
REACTOME POTASSIUM CHANNELS 102 2.44e-04 0.210000 1.33e-03
REACTOME COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 98 3.23e-04 0.210000 1.68e-03
REACTOME CDC42 GTPASE CYCLE 142 1.54e-05 0.210000 1.35e-04
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 55 7.14e-03 0.210000 2.03e-02
REACTOME RHOA GTPASE CYCLE 136 2.42e-05 0.209000 1.99e-04
REACTOME NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.04e-02 0.209000 7.99e-02
REACTOME AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 8 3.06e-01 0.209000 3.88e-01
REACTOME BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 8.27e-02 0.209000 1.40e-01
REACTOME RHOG GTPASE CYCLE 69 2.72e-03 0.209000 9.51e-03
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 15 1.63e-01 0.208000 2.38e-01
REACTOME TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 14 1.78e-01 0.208000 2.55e-01
REACTOME METABOLISM OF COFACTORS 19 1.17e-01 0.207000 1.84e-01
REACTOME SIGNALING BY PDGF 57 6.77e-03 0.207000 1.97e-02
REACTOME SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 42 2.02e-02 0.207000 4.64e-02
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.35e-01 0.207000 3.14e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 32 4.29e-02 0.207000 8.34e-02
REACTOME EICOSANOIDS 12 2.15e-01 -0.207000 2.92e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 30 5.09e-02 0.206000 9.51e-02
REACTOME GLYCOGEN STORAGE DISEASES 14 1.83e-01 0.206000 2.60e-01
REACTOME TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 109 2.05e-04 0.206000 1.18e-03
REACTOME CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 13 1.99e-01 0.206000 2.77e-01
REACTOME RRNA PROCESSING 181 1.78e-06 0.206000 2.04e-05
REACTOME INTEGRATION OF ENERGY METABOLISM 105 2.71e-04 0.205000 1.46e-03
REACTOME IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 2.38e-01 0.205000 3.19e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 245 2.90e-08 0.205000 5.25e-07
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 22 9.56e-02 0.205000 1.57e-01
REACTOME RAS SIGNALING DOWNSTREAM OF NF1 LOSS OF FUNCTION VARIANTS 7 3.47e-01 0.205000 4.30e-01
REACTOME RA BIOSYNTHESIS PATHWAY 22 9.58e-02 0.205000 1.57e-01
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 19 1.22e-01 0.205000 1.89e-01
REACTOME DISEASES OF MISMATCH REPAIR MMR 5 4.30e-01 0.204000 5.13e-01
REACTOME REGULATION OF NPAS4 GENE TRANSCRIPTION 5 4.30e-01 0.204000 5.13e-01
REACTOME STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 13 2.03e-01 0.204000 2.81e-01
REACTOME MET ACTIVATES RAP1 AND RAC1 11 2.42e-01 0.204000 3.23e-01
REACTOME PHASE 1 INACTIVATION OF FAST NA CHANNELS 6 3.88e-01 -0.203000 4.73e-01
REACTOME CLEC7A DECTIN 1 SIGNALING 96 5.73e-04 0.203000 2.69e-03
REACTOME VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 7.42e-02 0.202000 1.28e-01
REACTOME SARS COV 1 HOST INTERACTIONS 88 1.11e-03 0.201000 4.59e-03
REACTOME RND1 GTPASE CYCLE 41 2.59e-02 0.201000 5.62e-02
REACTOME XENOBIOTICS 23 9.57e-02 -0.201000 1.57e-01
REACTOME INTRAFLAGELLAR TRANSPORT 48 1.62e-02 0.201000 3.91e-02
REACTOME ESTROGEN STIMULATED SIGNALING THROUGH PRKCZ 6 3.95e-01 0.200000 4.80e-01
REACTOME THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 76 2.59e-03 0.200000 9.17e-03
REACTOME TRAFFICKING OF AMPA RECEPTORS 29 6.31e-02 0.199000 1.14e-01
REACTOME MITOCHONDRIAL CALCIUM ION TRANSPORT 16 1.70e-01 0.198000 2.45e-01
REACTOME REGULATION OF INSULIN SECRETION 77 2.64e-03 0.198000 9.28e-03
REACTOME NR1H2 AND NR1H3 MEDIATED SIGNALING 42 2.64e-02 0.198000 5.68e-02
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 2.79e-01 0.198000 3.61e-01
REACTOME UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 2.57e-01 0.197000 3.39e-01
REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 1.09e-01 0.197000 1.74e-01
REACTOME ROBO RECEPTORS BIND AKAP5 9 3.06e-01 0.197000 3.88e-01
REACTOME METABOLISM OF INGESTED SEMET SEC MESEC INTO H2SE 8 3.37e-01 0.196000 4.20e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 118 2.40e-04 0.196000 1.31e-03
REACTOME HEME DEGRADATION 15 1.90e-01 -0.196000 2.68e-01
REACTOME INFLUENZA INFECTION 147 4.20e-05 0.195000 3.17e-04
REACTOME DEFECTIVE LFNG CAUSES SCDO3 5 4.50e-01 0.195000 5.33e-01
REACTOME AGGREPHAGY 41 3.06e-02 0.195000 6.38e-02
REACTOME NEUROTRANSMITTER RELEASE CYCLE 47 2.07e-02 0.195000 4.74e-02
REACTOME HS GAG BIOSYNTHESIS 28 7.45e-02 0.195000 1.28e-01
REACTOME CD163 MEDIATING AN ANTI INFLAMMATORY RESPONSE 9 3.14e-01 0.194000 3.97e-01
REACTOME LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7 3.75e-01 0.193000 4.59e-01
REACTOME CELL CELL COMMUNICATION 117 2.97e-04 0.193000 1.57e-03
REACTOME SYNTHESIS OF 12 EICOSATETRAENOIC ACID DERIVATIVES 7 3.78e-01 0.192000 4.62e-01
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE 249 1.69e-07 0.192000 2.62e-06
REACTOME PYRUVATE METABOLISM 27 8.44e-02 0.192000 1.43e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 14 2.14e-01 0.192000 2.92e-01
REACTOME ATTACHMENT OF GPI ANCHOR TO UPAR 7 3.80e-01 0.192000 4.64e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 97 1.11e-03 0.191000 4.59e-03
REACTOME MAP2K AND MAPK ACTIVATION 38 4.17e-02 0.191000 8.19e-02
REACTOME SARS COV 1 INFECTION 131 1.60e-04 0.191000 9.79e-04
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 13 2.34e-01 0.191000 3.13e-01
REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK 111 5.29e-04 0.190000 2.53e-03
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 16 1.89e-01 0.190000 2.67e-01
REACTOME CHAPERONE MEDIATED AUTOPHAGY 20 1.43e-01 0.189000 2.15e-01
REACTOME CONDENSATION OF PROPHASE CHROMOSOMES 11 2.78e-01 0.189000 3.59e-01
REACTOME DISEASES OF CARBOHYDRATE METABOLISM 30 7.39e-02 0.188000 1.28e-01
REACTOME DOWNREGULATION OF ERBB2 SIGNALING 28 8.46e-02 0.188000 1.43e-01
REACTOME CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 3.03e-01 0.188000 3.86e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 18 1.68e-01 0.188000 2.42e-01
REACTOME GAP JUNCTION DEGRADATION 12 2.60e-01 0.188000 3.42e-01
REACTOME BH3 ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI APOPTOTIC BCL 2 MEMBERS 9 3.32e-01 0.187000 4.15e-01
REACTOME CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.36e-02 0.187000 5.21e-02
REACTOME CYP2E1 REACTIONS 11 2.84e-01 -0.187000 3.66e-01
REACTOME CELLULAR RESPONSE TO CHEMICAL STRESS 185 1.30e-05 0.186000 1.18e-04
REACTOME RHO GTPASES ACTIVATE IQGAPS 31 7.46e-02 0.185000 1.28e-01
REACTOME ACTIVATION OF C3 AND C5 6 4.33e-01 -0.185000 5.16e-01
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 9 3.37e-01 0.185000 4.20e-01
REACTOME DEFECTIVE RIPK1 MEDIATED REGULATED NECROSIS 7 3.97e-01 0.185000 4.82e-01
REACTOME CIPROFLOXACIN ADME 5 4.74e-01 -0.185000 5.58e-01
REACTOME NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 2.89e-01 0.185000 3.71e-01
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 13 2.50e-01 0.184000 3.30e-01
REACTOME CELL CELL JUNCTION ORGANIZATION 57 1.60e-02 0.184000 3.87e-02
REACTOME NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 193 9.86e-06 0.184000 9.35e-05
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 19 1.65e-01 0.184000 2.40e-01
REACTOME RAC1 GTPASE CYCLE 168 3.92e-05 0.184000 3.00e-04
REACTOME CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 77 5.42e-03 0.183000 1.64e-02
REACTOME ECM PROTEOGLYCANS 73 6.85e-03 0.183000 1.98e-02
REACTOME ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA 5 4.79e-01 0.183000 5.61e-01
REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES 23 1.29e-01 0.183000 1.99e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 23 1.29e-01 0.183000 1.99e-01
REACTOME TRIF MEDIATED PROGRAMMED CELL DEATH 9 3.43e-01 0.182000 4.26e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 53 2.19e-02 0.182000 4.94e-02
REACTOME TP53 REGULATES METABOLIC GENES 74 6.88e-03 0.182000 1.98e-02
REACTOME AZATHIOPRINE ADME 22 1.41e-01 0.181000 2.13e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 75 6.88e-03 0.180000 1.98e-02
REACTOME INTEGRIN SIGNALING 27 1.05e-01 0.180000 1.69e-01
REACTOME RECYCLING PATHWAY OF L1 42 4.33e-02 0.180000 8.39e-02
REACTOME DISEASES OF GLYCOSYLATION 132 3.47e-04 0.180000 1.78e-03
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 26 1.12e-01 0.180000 1.77e-01
REACTOME REGULATION OF IFNG SIGNALING 14 2.44e-01 0.180000 3.24e-01
REACTOME CATION COUPLED CHLORIDE COTRANSPORTERS 7 4.10e-01 0.180000 4.93e-01
REACTOME BASIGIN INTERACTIONS 24 1.28e-01 0.179000 1.97e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 98 2.14e-03 0.179000 7.88e-03
REACTOME DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 14 2.46e-01 0.179000 3.26e-01
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS 30 9.02e-02 -0.179000 1.49e-01
REACTOME MRNA EDITING C TO U CONVERSION 8 3.82e-01 -0.179000 4.66e-01
REACTOME BUTYROPHILIN BTN FAMILY INTERACTIONS 12 2.85e-01 0.178000 3.67e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING 5 4.91e-01 0.178000 5.72e-01
REACTOME MOLYBDENUM COFACTOR BIOSYNTHESIS 6 4.52e-01 0.177000 5.34e-01
REACTOME RECYCLING OF BILE ACIDS AND SALTS 16 2.20e-01 -0.177000 2.97e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 254 1.14e-06 0.177000 1.43e-05
REACTOME CELL JUNCTION ORGANIZATION 82 5.60e-03 0.177000 1.68e-02
REACTOME SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 31 8.87e-02 0.177000 1.48e-01
REACTOME THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 1.13e-01 0.176000 1.78e-01
REACTOME MET ACTIVATES RAS SIGNALING 11 3.11e-01 0.176000 3.94e-01
REACTOME CILIUM ASSEMBLY 184 3.64e-05 0.176000 2.82e-04
REACTOME GLUCOSE METABOLISM 85 5.04e-03 0.176000 1.56e-02
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES 30 9.57e-02 -0.176000 1.57e-01
REACTOME INTERLEUKIN 1 PROCESSING 9 3.62e-01 -0.176000 4.45e-01
REACTOME INTERLEUKIN 21 SIGNALING 9 3.62e-01 0.175000 4.46e-01
REACTOME FATTY ACID METABOLISM 163 1.10e-04 0.175000 7.25e-04
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 15 2.41e-01 0.175000 3.21e-01
REACTOME EARLY PHASE OF HIV LIFE CYCLE 14 2.57e-01 0.175000 3.39e-01
REACTOME SIGNALING BY MET 78 7.70e-03 0.174000 2.15e-02
REACTOME ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 41 5.44e-02 0.174000 1.01e-01
REACTOME INTERLEUKIN 1 FAMILY SIGNALING 145 3.04e-04 0.174000 1.59e-03
REACTOME DEPOLYMERISATION OF THE NUCLEAR LAMINA 14 2.61e-01 0.173000 3.42e-01
REACTOME PHASE 3 RAPID REPOLARISATION 8 3.96e-01 0.173000 4.81e-01
REACTOME NEURONAL SYSTEM 387 4.47e-09 0.173000 1.06e-07
REACTOME G ALPHA Q SIGNALLING EVENTS 203 2.06e-05 0.173000 1.73e-04
REACTOME DISEASES OF METABOLISM 229 6.24e-06 0.173000 6.24e-05
REACTOME PI METABOLISM 78 8.25e-03 0.173000 2.28e-02
REACTOME TOLL LIKE RECEPTOR CASCADES 154 2.10e-04 0.173000 1.20e-03
REACTOME PRE NOTCH PROCESSING IN GOLGI 18 2.06e-01 0.172000 2.84e-01
REACTOME RAB GERANYLGERANYLATION 56 2.59e-02 0.172000 5.62e-02
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 11 3.24e-01 -0.172000 4.06e-01
REACTOME TRAIL SIGNALING 8 4.01e-01 0.171000 4.85e-01
REACTOME SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 14 2.67e-01 0.171000 3.48e-01
REACTOME LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX 5 5.09e-01 0.171000 5.88e-01
REACTOME NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 20 1.87e-01 0.170000 2.65e-01
REACTOME ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 87 6.14e-03 0.170000 1.81e-02
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 26 1.35e-01 0.169000 2.05e-01
REACTOME PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING 5 5.12e-01 0.169000 5.91e-01
REACTOME PHASE 2 PLATEAU PHASE 14 2.73e-01 0.169000 3.54e-01
REACTOME DISORDERS OF TRANSMEMBRANE TRANSPORTERS 166 1.69e-04 0.169000 1.02e-03
REACTOME ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 89 5.88e-03 0.169000 1.75e-02
REACTOME CELLULAR RESPONSE TO STARVATION 142 5.15e-04 0.169000 2.48e-03
REACTOME RELAXIN RECEPTORS 8 4.10e-01 0.168000 4.93e-01
REACTOME ALPHA OXIDATION OF PHYTANATE 6 4.76e-01 0.168000 5.59e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION 39 7.00e-02 0.168000 1.24e-01
REACTOME DAG AND IP3 SIGNALING 39 7.05e-02 0.167000 1.24e-01
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 14 2.80e-01 0.167000 3.61e-01
REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.08e-01 0.167000 2.87e-01
REACTOME MISCELLANEOUS SUBSTRATES 12 3.17e-01 -0.167000 4.00e-01
REACTOME INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 45 5.30e-02 0.167000 9.86e-02
REACTOME RAS PROCESSING 20 1.98e-01 0.166000 2.76e-01
REACTOME SCAVENGING BY CLASS F RECEPTORS 6 4.81e-01 0.166000 5.62e-01
REACTOME VESICLE MEDIATED TRANSPORT 678 1.19e-13 0.166000 6.14e-12
REACTOME METABOLISM OF LIPIDS 678 1.21e-13 0.166000 6.14e-12
REACTOME ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 2.11e-01 0.166000 2.88e-01
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 89 6.88e-03 0.166000 1.98e-02
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY 14 2.83e-01 0.166000 3.65e-01
REACTOME RESPONSE OF MTB TO PHAGOCYTOSIS 22 1.79e-01 0.165000 2.56e-01
REACTOME TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 29 1.23e-01 0.165000 1.90e-01
REACTOME CD28 CO STIMULATION 32 1.06e-01 0.165000 1.70e-01
REACTOME SULFIDE OXIDATION TO SULFATE 5 5.23e-01 0.165000 6.01e-01
REACTOME SERINE BIOSYNTHESIS 9 3.92e-01 0.165000 4.76e-01
REACTOME REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 11 3.44e-01 0.165000 4.27e-01
REACTOME FORMATION OF THE CORNIFIED ENVELOPE 128 1.27e-03 -0.165000 5.09e-03
REACTOME SYNTHESIS OF PE 11 3.45e-01 0.165000 4.27e-01
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS 12 3.24e-01 0.164000 4.06e-01
REACTOME G PROTEIN MEDIATED EVENTS 52 4.03e-02 0.164000 7.97e-02
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 115 2.35e-03 0.164000 8.45e-03
REACTOME DEVELOPMENTAL BIOLOGY 1052 1.15e-19 0.164000 1.17e-17
REACTOME ZINC TRANSPORTERS 15 2.74e-01 0.163000 3.55e-01
REACTOME BETA OXIDATION OF PRISTANOYL COA 9 3.97e-01 0.163000 4.82e-01
REACTOME HEME SIGNALING 45 5.90e-02 0.163000 1.08e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.20e-01 0.163000 2.97e-01
REACTOME SHC1 EVENTS IN ERBB2 SIGNALING 22 1.90e-01 0.161000 2.68e-01
REACTOME CRISTAE FORMATION 9 4.04e-01 0.161000 4.88e-01
REACTOME RUNX2 REGULATES CHONDROCYTE MATURATION 5 5.34e-01 0.160000 6.12e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 181 1.93e-04 0.160000 1.14e-03
REACTOME SIALIC ACID METABOLISM 33 1.13e-01 0.159000 1.78e-01
REACTOME PURINE CATABOLISM 15 2.87e-01 0.159000 3.68e-01
REACTOME PLATELET CALCIUM HOMEOSTASIS 27 1.54e-01 0.158000 2.28e-01
REACTOME PKA ACTIVATION IN GLUCAGON SIGNALLING 17 2.60e-01 0.158000 3.41e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION 6 5.03e-01 0.158000 5.83e-01
REACTOME PARASITE INFECTION 106 5.04e-03 -0.158000 1.56e-02
REACTOME PEROXISOMAL LIPID METABOLISM 28 1.49e-01 0.157000 2.22e-01
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 4.36e-02 0.157000 8.43e-02
REACTOME RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION 6 5.05e-01 0.157000 5.85e-01
REACTOME TNFR2 NON CANONICAL NF KB PATHWAY 95 8.40e-03 0.156000 2.31e-02
REACTOME KILLING MECHANISMS 11 3.70e-01 0.156000 4.53e-01
REACTOME CYTOPROTECTION BY HMOX1 58 3.96e-02 0.156000 7.85e-02
REACTOME DSCAM INTERACTIONS 11 3.71e-01 0.156000 4.54e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT 51 5.47e-02 0.155000 1.01e-01
REACTOME GAP JUNCTION TRAFFICKING AND REGULATION 49 6.03e-02 0.155000 1.10e-01
REACTOME RHOBTB3 ATPASE CYCLE 8 4.49e-01 0.155000 5.31e-01
REACTOME PD 1 SIGNALING 24 1.92e-01 -0.154000 2.70e-01
REACTOME NUCLEAR SIGNALING BY ERBB4 32 1.32e-01 0.154000 2.02e-01
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 9 4.24e-01 0.154000 5.07e-01
REACTOME METABOLISM OF STEROIDS 143 1.51e-03 0.154000 5.88e-03
REACTOME PROTEIN METHYLATION 12 3.58e-01 0.153000 4.41e-01
REACTOME ACYL CHAIN REMODELING OF DAG AND TAG 5 5.53e-01 0.153000 6.30e-01
REACTOME INSULIN PROCESSING 23 2.04e-01 0.153000 2.83e-01
REACTOME PREDNISONE ADME 10 4.04e-01 -0.152000 4.88e-01
REACTOME REPRODUCTION 81 1.77e-02 0.152000 4.19e-02
REACTOME UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 1.56e-01 0.152000 2.30e-01
REACTOME DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A 5 5.55e-01 0.152000 6.31e-01
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS 7 4.86e-01 0.152000 5.66e-01
REACTOME ADHERENS JUNCTIONS INTERACTIONS 28 1.65e-01 0.152000 2.40e-01
REACTOME NONSENSE MEDIATED DECAY NMD 108 6.46e-03 0.152000 1.89e-02
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 23 2.09e-01 0.151000 2.87e-01
REACTOME PEROXISOMAL PROTEIN IMPORT 62 4.01e-02 0.151000 7.94e-02
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 82 1.84e-02 0.150000 4.34e-02
REACTOME METAL ION SLC TRANSPORTERS 23 2.13e-01 0.150000 2.90e-01
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 15 3.15e-01 -0.150000 3.97e-01
REACTOME METHYLATION 14 3.32e-01 0.150000 4.15e-01
REACTOME AMINE LIGAND BINDING RECEPTORS 40 1.01e-01 0.150000 1.63e-01
REACTOME MULTIFUNCTIONAL ANION EXCHANGERS 9 4.38e-01 -0.149000 5.20e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION 119 4.93e-03 0.149000 1.54e-02
REACTOME PECAM1 INTERACTIONS 11 3.92e-01 0.149000 4.77e-01
REACTOME TRANSPORT AND SYNTHESIS OF PAPS 6 5.28e-01 0.149000 6.06e-01
REACTOME ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION 10 4.15e-01 0.149000 4.98e-01
REACTOME MYOGENESIS 29 1.66e-01 0.148000 2.41e-01
REACTOME SODIUM COUPLED SULPHATE DI AND TRI CARBOXYLATE TRANSPORTERS 5 5.67e-01 -0.148000 6.41e-01
REACTOME FERTILIZATION 26 1.92e-01 -0.148000 2.70e-01
REACTOME INTERLEUKIN 12 SIGNALING 44 9.02e-02 0.148000 1.49e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 100 1.09e-02 0.147000 2.86e-02
REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 2.23e-01 0.147000 3.00e-01
REACTOME INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 25 2.06e-01 0.146000 2.84e-01
REACTOME SIGNALING BY INTERLEUKINS 434 1.69e-07 0.146000 2.62e-06
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 105 1.02e-02 0.145000 2.71e-02
REACTOME INTERFERON SIGNALING 194 4.90e-04 0.145000 2.38e-03
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 178 8.55e-04 -0.145000 3.73e-03
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.30e-01 0.144000 5.13e-01
REACTOME TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 55 6.44e-02 0.144000 1.15e-01
REACTOME GAP JUNCTION ASSEMBLY 36 1.35e-01 0.144000 2.05e-01
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH RAS 8 4.82e-01 0.144000 5.63e-01
REACTOME INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 25 2.16e-01 0.143000 2.93e-01
REACTOME ASPARTATE AND ASPARAGINE METABOLISM 11 4.12e-01 0.143000 4.94e-01
REACTOME VXPX CARGO TARGETING TO CILIUM 20 2.69e-01 0.143000 3.50e-01
REACTOME ACYL CHAIN REMODELLING OF PE 24 2.26e-01 -0.143000 3.04e-01
REACTOME GLYCEROPHOSPHOLIPID CATABOLISM 7 5.13e-01 0.143000 5.91e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 73 3.49e-02 0.143000 7.12e-02
REACTOME DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 2.69e-01 0.143000 3.50e-01
REACTOME P2Y RECEPTORS 9 4.60e-01 0.142000 5.43e-01
REACTOME INFECTIOUS DISEASE 889 4.22e-13 0.142000 1.91e-11
REACTOME CD209 DC SIGN SIGNALING 20 2.71e-01 0.142000 3.52e-01
REACTOME HYDROLYSIS OF LPC 9 4.61e-01 -0.142000 5.43e-01
REACTOME ACYL CHAIN REMODELLING OF PC 26 2.10e-01 -0.142000 2.88e-01
REACTOME TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 20 2.72e-01 0.142000 3.53e-01
REACTOME GLUTATHIONE CONJUGATION 35 1.47e-01 0.142000 2.20e-01
REACTOME UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 19 2.86e-01 0.141000 3.68e-01
REACTOME SIGNALING BY GPCR 656 5.33e-10 0.141000 1.52e-08
REACTOME CA DEPENDENT EVENTS 35 1.48e-01 0.141000 2.21e-01
REACTOME SODIUM CALCIUM EXCHANGERS 10 4.40e-01 0.141000 5.23e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 28 1.98e-01 0.140000 2.76e-01
REACTOME SODIUM PROTON EXCHANGERS 7 5.21e-01 0.140000 5.99e-01
REACTOME SARS COV 2 HOST INTERACTIONS 186 9.72e-04 0.140000 4.12e-03
REACTOME TCR SIGNALING 114 9.92e-03 0.140000 2.65e-02
REACTOME NRCAM INTERACTIONS 6 5.55e-01 0.139000 6.31e-01
REACTOME PIWI INTERACTING RNA PIRNA BIOGENESIS 29 1.95e-01 0.139000 2.73e-01
REACTOME CHYLOMICRON REMODELING 10 4.48e-01 -0.139000 5.31e-01
REACTOME INTERFERON ALPHA BETA SIGNALING 72 4.19e-02 0.139000 8.21e-02
REACTOME CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 25 2.34e-01 0.138000 3.13e-01
REACTOME DEFECTIVE EXT2 CAUSES EXOSTOSES 2 12 4.09e-01 -0.138000 4.93e-01
REACTOME VLDL ASSEMBLY 5 5.98e-01 -0.136000 6.69e-01
REACTOME INTEGRATION OF PROVIRUS 9 4.80e-01 0.136000 5.62e-01
REACTOME ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 124 9.16e-03 -0.135000 2.48e-02
REACTOME THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 23 2.62e-01 -0.135000 3.42e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 48 1.06e-01 0.135000 1.70e-01
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 281 1.10e-04 0.134000 7.25e-04
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 24 2.57e-01 0.134000 3.39e-01
REACTOME ERBB2 REGULATES CELL MOTILITY 15 3.71e-01 0.134000 4.54e-01
REACTOME EUKARYOTIC TRANSLATION INITIATION 112 1.46e-02 0.133000 3.58e-02
REACTOME RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 19 3.14e-01 0.133000 3.97e-01
REACTOME AMYLOID FIBER FORMATION 50 1.03e-01 0.133000 1.66e-01
REACTOME GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 36 1.67e-01 0.133000 2.42e-01
REACTOME ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 23 2.70e-01 0.133000 3.51e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 11 4.46e-01 0.133000 5.29e-01
REACTOME INTERLEUKIN 12 FAMILY SIGNALING 54 9.16e-02 0.133000 1.52e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS 57 8.39e-02 -0.132000 1.42e-01
REACTOME INFLAMMASOMES 21 2.94e-01 0.132000 3.77e-01
REACTOME ACYL CHAIN REMODELLING OF PS 21 2.95e-01 -0.132000 3.78e-01
REACTOME LIPOPHAGY 9 4.94e-01 0.132000 5.74e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS 26 2.45e-01 0.132000 3.26e-01
REACTOME TYSND1 CLEAVES PEROXISOMAL PROTEINS 7 5.49e-01 0.131000 6.26e-01
REACTOME ACYL CHAIN REMODELING OF CL 5 6.13e-01 0.131000 6.83e-01
REACTOME ACTIVATION OF NIMA KINASES NEK9 NEK6 NEK7 7 5.50e-01 0.130000 6.27e-01
REACTOME RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS 9 4.99e-01 0.130000 5.79e-01
REACTOME THYROXINE BIOSYNTHESIS 10 4.77e-01 0.130000 5.60e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 677 7.17e-09 0.130000 1.58e-07
REACTOME MATURATION OF SARS COV 1 SPIKE PROTEIN 5 6.17e-01 0.129000 6.86e-01
REACTOME SYNDECAN INTERACTIONS 26 2.54e-01 0.129000 3.35e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 25 2.64e-01 0.129000 3.44e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 10 4.80e-01 0.129000 5.62e-01
REACTOME PEPTIDE HORMONE METABOLISM 80 4.61e-02 0.129000 8.77e-02
REACTOME LONG TERM POTENTIATION 22 2.97e-01 0.128000 3.80e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 338 4.78e-05 0.128000 3.54e-04
REACTOME PHENYLALANINE AND TYROSINE METABOLISM 10 4.84e-01 0.128000 5.65e-01
REACTOME DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B 7 5.58e-01 0.128000 6.34e-01
REACTOME GPCR LIGAND BINDING 428 5.44e-06 0.128000 5.58e-05
REACTOME SYNTHESIS OF 5 EICOSATETRAENOIC ACIDS 9 5.08e-01 0.127000 5.88e-01
REACTOME SARS COV 2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES 114 1.91e-02 0.127000 4.45e-02
REACTOME VASOPRESSIN LIKE RECEPTORS 5 6.25e-01 0.126000 6.94e-01
REACTOME PHOSPHOLIPID METABOLISM 190 2.85e-03 0.125000 9.88e-03
REACTOME L1CAM INTERACTIONS 111 2.26e-02 0.125000 5.04e-02
REACTOME INSULIN RECEPTOR RECYCLING 29 2.44e-01 0.125000 3.24e-01
REACTOME EGFR INTERACTS WITH PHOSPHOLIPASE C GAMMA 9 5.18e-01 -0.124000 5.97e-01
REACTOME ACYL CHAIN REMODELLING OF PG 18 3.62e-01 -0.124000 4.45e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY DVL INTERACTING PROTEINS 5 6.32e-01 0.124000 7.00e-01
REACTOME SYNTHESIS OF LIPOXINS LX 6 6.00e-01 0.124000 6.69e-01
REACTOME RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 3.82e-02 0.124000 7.64e-02
REACTOME EUKARYOTIC TRANSLATION ELONGATION 88 4.56e-02 0.123000 8.71e-02
REACTOME SARS COV 2 INFECTION 275 4.35e-04 0.123000 2.15e-03
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 30 2.44e-01 0.123000 3.24e-01
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 55 1.17e-01 0.122000 1.83e-01
REACTOME REGULATED NECROSIS 55 1.17e-01 0.122000 1.83e-01
REACTOME ALK MUTANTS BIND TKIS 12 4.64e-01 0.122000 5.47e-01
REACTOME UNWINDING OF DNA 12 4.70e-01 0.120000 5.54e-01
REACTOME P75NTR REGULATES AXONOGENESIS 9 5.32e-01 0.120000 6.10e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 23 3.18e-01 0.120000 4.00e-01
REACTOME MET ACTIVATES PTPN11 5 6.42e-01 0.120000 7.07e-01
REACTOME INTERFERON GAMMA SIGNALING 89 5.07e-02 0.120000 9.48e-02
REACTOME MRNA EDITING 10 5.13e-01 -0.119000 5.91e-01
REACTOME EARLY SARS COV 2 INFECTION EVENTS 33 2.40e-01 0.118000 3.21e-01
REACTOME KINESINS 59 1.18e-01 0.118000 1.84e-01
REACTOME DNA DAMAGE REVERSAL 8 5.67e-01 0.117000 6.41e-01
REACTOME LATE SARS COV 2 INFECTION EVENTS 67 9.79e-02 0.117000 1.59e-01
REACTOME ACTIVATION OF RAS IN B CELLS 5 6.51e-01 0.117000 7.14e-01
REACTOME CHYLOMICRON CLEARANCE 5 6.54e-01 0.116000 7.17e-01
REACTOME COENZYME A BIOSYNTHESIS 8 5.72e-01 0.115000 6.46e-01
REACTOME OAS ANTIVIRAL RESPONSE 7 5.99e-01 -0.115000 6.69e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING 6 6.27e-01 0.115000 6.95e-01
REACTOME STRIATED MUSCLE CONTRACTION 35 2.42e-01 0.114000 3.23e-01
REACTOME LDL REMODELING 6 6.30e-01 -0.114000 6.98e-01
REACTOME G ALPHA S SIGNALLING EVENTS 152 1.58e-02 0.113000 3.84e-02
REACTOME MUSCLE CONTRACTION 194 6.46e-03 0.113000 1.89e-02
REACTOME ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 28 3.00e-01 0.113000 3.83e-01
REACTOME DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 17 4.20e-01 0.113000 5.02e-01
REACTOME HDL CLEARANCE 5 6.62e-01 0.113000 7.25e-01
REACTOME SELENOAMINO ACID METABOLISM 103 4.80e-02 0.113000 9.07e-02
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 17 4.21e-01 0.113000 5.04e-01
REACTOME MUSCARINIC ACETYLCHOLINE RECEPTORS 5 6.63e-01 -0.113000 7.25e-01
REACTOME CLASS A 1 RHODOPSIN LIKE RECEPTORS 300 8.25e-04 0.112000 3.64e-03
REACTOME TRANSPORT OF FATTY ACIDS 8 5.85e-01 0.112000 6.57e-01
REACTOME IRS ACTIVATION 5 6.66e-01 0.111000 7.28e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES 6 6.37e-01 0.111000 7.04e-01
REACTOME INTERLEUKIN 37 SIGNALING 20 3.90e-01 0.111000 4.74e-01
REACTOME PEPTIDE HORMONE BIOSYNTHESIS 12 5.07e-01 0.111000 5.86e-01
REACTOME DEFECTIVE F9 ACTIVATION 5 6.69e-01 0.110000 7.30e-01
REACTOME SLC TRANSPORTER DISORDERS 91 6.88e-02 0.110000 1.22e-01
REACTOME MET PROMOTES CELL MOTILITY 41 2.22e-01 0.110000 3.00e-01
REACTOME SYNTHESIS OF PG 8 5.90e-01 0.110000 6.62e-01
REACTOME SUPPRESSION OF PHAGOSOMAL MATURATION 13 4.94e-01 0.110000 5.74e-01
REACTOME TRNA MODIFICATION IN THE MITOCHONDRION 6 6.42e-01 0.109000 7.07e-01
REACTOME TRANSPORT OF SMALL MOLECULES 685 9.32e-07 0.109000 1.23e-05
REACTOME CA2 ACTIVATED K CHANNELS 9 5.71e-01 -0.109000 6.46e-01
REACTOME ARYL HYDROCARBON RECEPTOR SIGNALLING 6 6.45e-01 0.109000 7.10e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 4.19e-01 0.107000 5.02e-01
REACTOME ACROSOME REACTION AND SPERM OOCYTE MEMBRANE BINDING 6 6.50e-01 -0.107000 7.13e-01
REACTOME NICOTINAMIDE SALVAGING 16 4.59e-01 0.107000 5.42e-01
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 18 4.35e-01 0.106000 5.18e-01
REACTOME FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 131 3.62e-02 -0.106000 7.35e-02
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 149 2.56e-02 0.106000 5.58e-02
REACTOME METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 32 3.04e-01 0.105000 3.87e-01
REACTOME CROSS PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS PHAGOSOMES 7 6.35e-01 -0.104000 7.02e-01
REACTOME DAP12 SIGNALING 28 3.43e-01 0.103000 4.26e-01
REACTOME SYNTHESIS OF 16 20 HYDROXYEICOSATETRAENOIC ACIDS HETE 9 5.91e-01 -0.103000 6.62e-01
REACTOME NICOTINATE METABOLISM 25 3.71e-01 0.103000 4.54e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY 19 4.36e-01 -0.103000 5.18e-01
REACTOME REGULATION OF SIGNALING BY NODAL 11 5.53e-01 0.103000 6.30e-01
REACTOME VITAMIN D CALCIFEROL METABOLISM 12 5.38e-01 0.103000 6.15e-01
REACTOME CHYLOMICRON ASSEMBLY 10 5.76e-01 -0.102000 6.50e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 5 6.95e-01 0.101000 7.50e-01
REACTOME INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 105 7.24e-02 0.101000 1.26e-01
REACTOME INTERLEUKIN 20 FAMILY SIGNALING 22 4.13e-01 0.101000 4.96e-01
REACTOME CD28 DEPENDENT VAV1 PATHWAY 11 5.66e-01 -0.099900 6.41e-01
REACTOME METABOLISM OF AMINE DERIVED HORMONES 17 4.79e-01 -0.099200 5.61e-01
REACTOME SARS COV 2 MODULATES HOST TRANSLATION MACHINERY 47 2.48e-01 0.097400 3.28e-01
REACTOME TRANSPORT OF RCBL WITHIN THE BODY 8 6.33e-01 0.097400 7.01e-01
REACTOME METABOLISM OF NUCLEOTIDES 86 1.20e-01 0.096900 1.87e-01
REACTOME SENSORY PROCESSING OF SOUND 69 1.64e-01 0.096800 2.40e-01
REACTOME CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 44 2.68e-01 0.096500 3.49e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 113 7.62e-02 0.096500 1.31e-01
REACTOME CARDIAC CONDUCTION 125 6.44e-02 0.095700 1.15e-01
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 14 5.43e-01 0.093900 6.20e-01
REACTOME AFLATOXIN ACTIVATION AND DETOXIFICATION 19 4.81e-01 0.093500 5.62e-01
REACTOME PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 77 1.57e-01 0.093200 2.31e-01
REACTOME REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA CARBOXYLATED PROTEINS 8 6.48e-01 -0.093100 7.12e-01
REACTOME PYRIMIDINE CATABOLISM 11 5.94e-01 -0.092900 6.64e-01
REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 20 4.73e-01 0.092700 5.56e-01
REACTOME PROTON COUPLED MONOCARBOXYLATE TRANSPORT 6 6.96e-01 -0.092200 7.50e-01
REACTOME POLO LIKE KINASE MEDIATED EVENTS 16 5.27e-01 0.091300 6.05e-01
REACTOME PROTEIN REPAIR 6 6.99e-01 -0.091000 7.54e-01
REACTOME C TYPE LECTIN RECEPTORS CLRS 135 6.88e-02 0.090600 1.22e-01
REACTOME PHOSPHORYLATION OF EMI1 6 7.09e-01 -0.087900 7.63e-01
REACTOME PASSIVE TRANSPORT BY AQUAPORINS 13 5.86e-01 -0.087200 6.58e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 20 5.01e-01 0.087000 5.80e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 234 2.24e-02 0.086500 5.01e-02
REACTOME PHASE I FUNCTIONALIZATION OF COMPOUNDS 98 1.41e-01 0.086000 2.13e-01
REACTOME DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 77 1.92e-01 0.085900 2.70e-01
REACTOME SARS COV 1 MODULATES HOST TRANSLATION MACHINERY 34 3.87e-01 0.085800 4.71e-01
REACTOME RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 5.81e-01 0.085100 6.54e-01
REACTOME TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 82 1.83e-01 0.084900 2.61e-01
REACTOME TRP CHANNELS 27 4.53e-01 0.083400 5.36e-01
REACTOME PROLACTIN RECEPTOR SIGNALING 15 5.79e-01 0.082800 6.52e-01
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 15 5.79e-01 0.082700 6.52e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS 34 4.08e-01 0.082000 4.91e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 17 5.60e-01 0.081600 6.35e-01
REACTOME PHOSPHORYLATION OF THE APC C 19 5.38e-01 0.081500 6.15e-01
REACTOME ADAPTIVE IMMUNE SYSTEM 771 1.10e-04 0.081300 7.25e-04
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING 5 7.53e-01 -0.081100 8.05e-01
REACTOME REDUCTION OF CYTOSOLIC CA LEVELS 11 6.42e-01 0.080900 7.07e-01
REACTOME METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 114 1.38e-01 0.080400 2.09e-01
REACTOME ARACHIDONIC ACID METABOLISM 56 2.98e-01 0.080300 3.81e-01
REACTOME GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 30 4.48e-01 0.080000 5.31e-01
REACTOME SARS COV INFECTIONS 434 4.21e-03 0.079800 1.35e-02
REACTOME HEMOSTASIS 622 6.43e-04 0.079700 2.93e-03
REACTOME REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 5 7.58e-01 0.079500 8.08e-01
REACTOME ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 11 6.48e-01 0.079500 7.12e-01
REACTOME RSK ACTIVATION 5 7.59e-01 0.079300 8.08e-01
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 37 4.07e-01 0.078700 4.91e-01
REACTOME ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 6.68e-01 0.078400 7.29e-01
REACTOME INTERLEUKIN 23 SIGNALING 9 6.84e-01 -0.078300 7.43e-01
REACTOME NEUREXINS AND NEUROLIGINS 51 3.34e-01 0.078100 4.18e-01
REACTOME BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 19 5.59e-01 0.077500 6.34e-01
REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 16 5.92e-01 0.077400 6.63e-01
REACTOME INTERLEUKIN 2 FAMILY SIGNALING 40 4.05e-01 0.076000 4.89e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27 HYDROXYCHOLESTEROL 15 6.11e-01 -0.075800 6.81e-01
REACTOME COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 59 3.15e-01 0.075600 3.97e-01
REACTOME DISSOLUTION OF FIBRIN CLOT 13 6.39e-01 0.075200 7.05e-01
REACTOME DRUG ADME 107 1.80e-01 -0.074900 2.57e-01
REACTOME KETONE BODY METABOLISM 10 6.82e-01 0.074900 7.41e-01
REACTOME BIOLOGICAL OXIDATIONS 211 6.09e-02 0.074700 1.11e-01
REACTOME SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 49 3.66e-01 0.074600 4.49e-01
REACTOME RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION 6 7.53e-01 0.074200 8.05e-01
REACTOME INTERLEUKIN RECEPTOR SHC SIGNALING 24 5.31e-01 0.073900 6.09e-01
REACTOME TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION 5 7.75e-01 0.073800 8.24e-01
REACTOME GLUCURONIDATION 24 5.35e-01 -0.073200 6.12e-01
REACTOME OTHER SEMAPHORIN INTERACTIONS 18 5.91e-01 0.073200 6.62e-01
REACTOME ORGANIC CATION TRANSPORT 10 6.89e-01 0.073200 7.46e-01
REACTOME MET ACTIVATES PTK2 SIGNALING 30 4.95e-01 0.072000 5.75e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS 176 9.98e-02 0.071800 1.62e-01
REACTOME ABC TRANSPORTERS IN LIPID HOMEOSTASIS 17 6.12e-01 -0.071000 6.82e-01
REACTOME FCERI MEDIATED NF KB ACTIVATION 124 1.73e-01 -0.070800 2.49e-01
REACTOME SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 16 6.27e-01 0.070200 6.95e-01
REACTOME SYNAPTIC ADHESION LIKE MOLECULES 19 5.96e-01 0.070200 6.67e-01
REACTOME LTC4 CYSLTR MEDIATED IL4 PRODUCTION 6 7.70e-01 -0.068900 8.19e-01
REACTOME G ALPHA I SIGNALLING EVENTS 302 4.09e-02 0.068200 8.06e-02
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 61 3.61e-01 0.067600 4.45e-01
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 52 4.04e-01 -0.066800 4.88e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY 68 3.41e-01 0.066700 4.25e-01
REACTOME ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 6 7.79e-01 0.066300 8.27e-01
REACTOME INTESTINAL ABSORPTION 5 8.03e-01 0.064600 8.48e-01
REACTOME SIGNALING BY MST1 5 8.05e-01 -0.063700 8.49e-01
REACTOME NFE2L2 REGULATING ANTI OXIDANT DETOXIFICATION ENZYMES 17 6.50e-01 0.063600 7.13e-01
REACTOME NEUTROPHIL DEGRANULATION 448 2.12e-02 0.063300 4.82e-02
REACTOME STIMULI SENSING CHANNELS 100 2.80e-01 0.062500 3.61e-01
REACTOME HS GAG DEGRADATION 19 6.40e-01 0.061900 7.07e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 153 1.89e-01 -0.061400 2.67e-01
REACTOME HDL ASSEMBLY 8 7.64e-01 -0.061300 8.13e-01
REACTOME MATURATION OF SARS COV 2 SPIKE PROTEIN 35 5.32e-01 0.061000 6.10e-01
REACTOME RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES TREGS 9 7.57e-01 -0.059500 8.08e-01
REACTOME PYRIMIDINE SALVAGE 10 7.48e-01 0.058800 8.00e-01
REACTOME METABOLISM OF FOLATE AND PTERINES 16 6.87e-01 0.058200 7.45e-01
REACTOME GLUTATHIONE SYNTHESIS AND RECYCLING 12 7.29e-01 -0.057700 7.83e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS 5 8.23e-01 0.057700 8.64e-01
REACTOME ENDOGENOUS STEROLS 25 6.20e-01 0.057300 6.89e-01
REACTOME SCAVENGING BY CLASS A RECEPTORS 19 6.67e-01 0.057100 7.28e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM 16 6.95e-01 -0.056700 7.50e-01
REACTOME METABOLISM OF STEROID HORMONES 33 5.74e-01 0.056600 6.47e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES 51 4.86e-01 -0.056300 5.67e-01
REACTOME VISUAL PHOTOTRANSDUCTION 92 3.51e-01 -0.056300 4.34e-01
REACTOME INTERLEUKIN 18 SIGNALING 8 7.83e-01 -0.056200 8.31e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 16 7.02e-01 0.055300 7.56e-01
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 32 5.89e-01 -0.055200 6.61e-01
REACTOME ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 17 6.93e-01 -0.055200 7.50e-01
REACTOME UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN 6 8.15e-01 0.055000 8.58e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 62 4.72e-01 0.052800 5.56e-01
REACTOME SYNTHESIS OF KETONE BODIES 8 7.99e-01 0.052100 8.44e-01
REACTOME FIBRONECTIN MATRIX FORMATION 6 8.29e-01 0.050900 8.69e-01
REACTOME ABACAVIR ADME 9 7.92e-01 0.050700 8.39e-01
REACTOME CREB PHOSPHORYLATION 6 8.30e-01 0.050600 8.69e-01
REACTOME INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 21 6.89e-01 0.050500 7.46e-01
REACTOME N GLYCAN ANTENNAE ELONGATION 15 7.35e-01 0.050500 7.89e-01
REACTOME INTERLEUKIN 10 SIGNALING 43 5.67e-01 -0.050400 6.41e-01
REACTOME RHO GTPASES ACTIVATE NADPH OXIDASES 22 6.89e-01 -0.049300 7.46e-01
REACTOME COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 20 7.12e-01 0.047700 7.66e-01
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 14 7.59e-01 -0.047400 8.08e-01
REACTOME FRUCTOSE METABOLISM 6 8.41e-01 0.047300 8.78e-01
REACTOME NEF AND SIGNAL TRANSDUCTION 8 8.23e-01 0.045800 8.63e-01
REACTOME RIBAVIRIN ADME 11 7.95e-01 0.045300 8.41e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE 34 6.48e-01 0.045200 7.12e-01
REACTOME COLLAGEN FORMATION 80 4.97e-01 0.043900 5.77e-01
REACTOME ION CHANNEL TRANSPORT 172 3.25e-01 0.043500 4.07e-01
REACTOME FORMATION OF XYLULOSE 5 PHOSPHATE 5 8.67e-01 0.043200 8.99e-01
REACTOME GLUCONEOGENESIS 32 6.72e-01 0.043200 7.32e-01
REACTOME THE PHOTOTRANSDUCTION CASCADE 32 6.73e-01 0.043200 7.32e-01
REACTOME ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS 5 8.69e-01 0.042700 8.99e-01
REACTOME BIOTIN TRANSPORT AND METABOLISM 10 8.16e-01 -0.042500 8.58e-01
REACTOME OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 8 8.35e-01 0.042500 8.74e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 7.84e-01 -0.042300 8.31e-01
REACTOME HISTIDINE CATABOLISM 7 8.46e-01 0.042300 8.81e-01
REACTOME CLEC7A INFLAMMASOME PATHWAY 6 8.59e-01 -0.041900 8.91e-01
REACTOME TRYPTOPHAN CATABOLISM 12 8.05e-01 0.041200 8.49e-01
REACTOME ION HOMEOSTASIS 52 6.14e-01 0.040500 6.83e-01
REACTOME NUCLEOTIDE CATABOLISM 32 6.93e-01 0.040300 7.50e-01
REACTOME RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION 8 8.44e-01 -0.040000 8.80e-01
REACTOME METABOLISM OF PORPHYRINS 26 7.32e-01 0.038900 7.86e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 38 6.87e-01 -0.037800 7.45e-01
REACTOME DAP12 INTERACTIONS 39 6.86e-01 -0.037400 7.45e-01
REACTOME GAB1 SIGNALOSOME 17 7.92e-01 0.037000 8.39e-01
REACTOME PURINE SALVAGE 12 8.26e-01 -0.036600 8.66e-01
REACTOME PHASE II CONJUGATION OF COMPOUNDS 106 5.15e-01 0.036600 5.93e-01
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 26 7.47e-01 0.036600 8.00e-01
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT 15 8.07e-01 -0.036500 8.51e-01
REACTOME PENTOSE PHOSPHATE PATHWAY 11 8.40e-01 0.035100 8.78e-01
REACTOME PHASE 0 RAPID DEPOLARISATION 31 7.37e-01 -0.034800 7.90e-01
REACTOME ANCHORING FIBRIL FORMATION 13 8.36e-01 0.033100 8.75e-01
REACTOME G2 M DNA REPLICATION CHECKPOINT 5 8.99e-01 -0.032900 9.25e-01
REACTOME COLLAGEN DEGRADATION 58 6.65e-01 0.032900 7.27e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS 12 8.53e-01 -0.030900 8.87e-01
REACTOME SYNTHESIS OF EPOXY EET AND DIHYDROXYEICOSATRIENOIC ACIDS DHET 8 8.88e-01 0.028700 9.17e-01
REACTOME PLASMA LIPOPROTEIN REMODELING 32 7.80e-01 0.028600 8.28e-01
REACTOME N GLYCAN TRIMMING AND ELONGATION IN THE CIS GOLGI 5 9.15e-01 0.027400 9.38e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 24 8.19e-01 0.027000 8.60e-01
REACTOME IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN 5 9.17e-01 -0.026900 9.39e-01
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 9 8.95e-01 0.025500 9.23e-01
REACTOME DISEASES OF IMMUNE SYSTEM 29 8.12e-01 -0.025500 8.55e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS 8 9.02e-01 0.025300 9.26e-01
REACTOME SPERM MOTILITY AND TAXES 9 8.97e-01 0.025000 9.24e-01
REACTOME ATTACHMENT AND ENTRY 15 8.70e-01 0.024500 9.00e-01
REACTOME O LINKED GLYCOSYLATION 97 6.78e-01 0.024400 7.38e-01
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS 9 9.02e-01 -0.023800 9.26e-01
REACTOME REACTIONS SPECIFIC TO THE COMPLEX N GLYCAN SYNTHESIS PATHWAY 10 9.00e-01 0.023000 9.26e-01
REACTOME COMMON PATHWAY OF FIBRIN CLOT FORMATION 21 8.56e-01 0.022800 8.89e-01
REACTOME RETINOID CYCLE DISEASE EVENTS 11 8.96e-01 0.022800 9.24e-01
REACTOME MISCELLANEOUS TRANSPORT AND BINDING EVENTS 22 8.55e-01 -0.022500 8.89e-01
REACTOME LEISHMANIA INFECTION 206 5.80e-01 -0.022300 6.53e-01
REACTOME TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 26 8.44e-01 -0.022300 8.80e-01
REACTOME SYNTHESIS OF PA 35 8.21e-01 -0.022100 8.63e-01
REACTOME COLLAGEN CHAIN TRIMERIZATION 41 8.10e-01 -0.021700 8.54e-01
REACTOME PYROPTOSIS 26 8.52e-01 0.021200 8.87e-01
REACTOME METHIONINE SALVAGE PATHWAY 6 9.33e-01 0.019800 9.51e-01
REACTOME MET INTERACTS WITH TNS PROTEINS 5 9.40e-01 0.019500 9.56e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 85 7.56e-01 0.019500 8.07e-01
REACTOME DETOXIFICATION OF REACTIVE OXYGEN SPECIES 34 8.44e-01 0.019500 8.80e-01
REACTOME CELLULAR HEXOSE TRANSPORT 20 8.85e-01 -0.018600 9.15e-01
REACTOME POTENTIAL THERAPEUTICS FOR SARS 140 7.05e-01 -0.018500 7.59e-01
REACTOME VLDL CLEARANCE 6 9.37e-01 0.018500 9.54e-01
REACTOME UREA CYCLE 9 9.26e-01 0.018000 9.45e-01
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 15 9.04e-01 0.018000 9.28e-01
REACTOME ABACAVIR TRANSMEMBRANE TRANSPORT 5 9.45e-01 0.017900 9.61e-01
REACTOME EGFR TRANSACTIVATION BY GASTRIN 9 9.29e-01 0.017300 9.47e-01
REACTOME DNA METHYLATION 5 9.48e-01 0.016800 9.63e-01
REACTOME PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 9.24e-01 0.016700 9.44e-01
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 130 7.46e-01 0.016500 7.99e-01
REACTOME TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 10 9.28e-01 -0.016400 9.47e-01
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 9.19e-01 0.016300 9.41e-01
REACTOME ERBB2 ACTIVATES PTK6 SIGNALING 13 9.23e-01 0.015500 9.44e-01
REACTOME METABOLISM OF FAT SOLUBLE VITAMINS 45 8.59e-01 -0.015300 8.91e-01
REACTOME NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES 7 9.50e-01 -0.013800 9.64e-01
REACTOME BLOOD GROUP SYSTEMS BIOSYNTHESIS 21 9.15e-01 -0.013400 9.38e-01
REACTOME ROS AND RNS PRODUCTION IN PHAGOCYTES 35 8.92e-01 0.013200 9.21e-01
REACTOME TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 16 9.32e-01 -0.012400 9.50e-01
REACTOME TRIGLYCERIDE METABOLISM 35 9.01e-01 -0.012100 9.26e-01
REACTOME MATURATION OF PROTEIN 3A 9 9.50e-01 0.012000 9.65e-01
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 63 8.78e-01 -0.011200 9.08e-01
REACTOME BICARBONATE TRANSPORTERS 10 9.56e-01 0.010100 9.70e-01
REACTOME SYNTHESIS OF PIPS AT THE ER MEMBRANE 5 9.72e-01 -0.009010 9.82e-01
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 9 9.65e-01 0.008450 9.77e-01
REACTOME SYNTHESIS OF PI 5 9.74e-01 -0.008340 9.83e-01
REACTOME INDUCTION OF CELL CELL FUSION 12 9.61e-01 -0.008210 9.74e-01
REACTOME NEUROTRANSMITTER CLEARANCE 9 9.67e-01 0.008080 9.77e-01
REACTOME SCAVENGING BY CLASS B RECEPTORS 6 9.74e-01 0.007760 9.83e-01
REACTOME ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 57 9.21e-01 -0.007560 9.43e-01
REACTOME FC EPSILON RECEPTOR FCERI SIGNALING 173 8.65e-01 -0.007500 8.97e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL 14 9.66e-01 -0.006550 9.77e-01
REACTOME DEFECTS IN BIOTIN BTN METABOLISM 8 9.76e-01 -0.006210 9.84e-01
REACTOME TNFR1 MEDIATED CERAMIDE PRODUCTION 5 9.82e-01 0.005760 9.88e-01
REACTOME ARACHIDONATE PRODUCTION FROM DAG 5 9.84e-01 -0.005240 9.89e-01
REACTOME VITAMIN B2 RIBOFLAVIN METABOLISM 7 9.82e-01 -0.005030 9.88e-01
REACTOME PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 26 9.67e-01 0.004740 9.77e-01
REACTOME INNATE IMMUNE SYSTEM 1044 7.99e-01 -0.004630 8.44e-01
REACTOME CGMP EFFECTS 15 9.80e-01 -0.003810 9.86e-01
REACTOME NUCLEOTIDE SALVAGE 21 9.78e-01 -0.003430 9.86e-01
REACTOME TYROSINE CATABOLISM 5 9.90e-01 -0.003250 9.92e-01
REACTOME ANDROGEN BIOSYNTHESIS 11 9.88e-01 -0.002720 9.91e-01
REACTOME TRIGLYCERIDE CATABOLISM 23 9.85e-01 -0.002310 9.89e-01
REACTOME BILE ACID AND BILE SALT METABOLISM 43 9.79e-01 0.002300 9.86e-01
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 19 9.88e-01 0.002050 9.91e-01
REACTOME SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 21 9.91e-01 0.001350 9.93e-01
REACTOME SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 15 9.94e-01 -0.001090 9.95e-01
REACTOME PARACETAMOL ADME 29 9.98e-01 0.000262 9.98e-01
REACTOME NCAM1 INTERACTIONS 41 9.98e-01 0.000191 9.98e-01


Detailed Gene set reports



REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM

REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM
1602
set REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM
setSize 5
pANOVA 0.00047
s.dist 0.903
p.adjustANOVA 0.0023



Top enriched genes

Top 20 genes
GeneID Gene Rank
SHH 6252
FOXF1 5408
BMP4 5031
GATA4 4914
IHH 4421

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SHH 6252
FOXF1 5408
BMP4 5031
GATA4 4914
IHH 4421


REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS
421
set REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS
setSize 8
pANOVA 1.27e-05
s.dist 0.891
p.adjustANOVA 0.000116



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTF1A 6709
NKX6-1 6466
ONECUT1 6430
FGF10 6416
PDX1 6317
ONECUT3 5631
HNF1B 4885
NR5A2 -2832

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTF1A 6709
NKX6-1 6466
ONECUT1 6430
FGF10 6416
PDX1 6317
ONECUT3 5631
HNF1B 4885
NR5A2 -2832


REACTOME_OLFACTORY_SIGNALING_PATHWAY

REACTOME_OLFACTORY_SIGNALING_PATHWAY
626
set REACTOME_OLFACTORY_SIGNALING_PATHWAY
setSize 373
pANOVA 2.54e-141
s.dist -0.757
p.adjustANOVA 4.14e-138



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR6Q1 -27075
OR9I1 -27072
OR1S2 -27041
OR51I1 -27031
OR2T29 -27025
OR10W1 -27007
OR5H6 -27002
OR5H1 -26981
OR10K2 -26949
OR10J3 -26927
OR52D1 -26926
OR2M7 -26892
OR2M4 -26891
OR4C3 -26890
OR10Z1 -26873
OR52A5 -26870
OR5AC2 -26867
OR10G9 -26861
OR5H14 -26853
OR6P1 -26791

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR6Q1 -27075
OR9I1 -27072
OR1S2 -27041
OR51I1 -27031
OR2T29 -27025
OR10W1 -27007
OR5H6 -27002
OR5H1 -26981
OR10K2 -26949
OR10J3 -26927
OR52D1 -26926
OR2M7 -26892
OR2M4 -26891
OR4C3 -26890
OR10Z1 -26873
OR52A5 -26870
OR5AC2 -26867
OR10G9 -26861
OR5H14 -26853
OR6P1 -26791
OR10J1 -26778
OR2L5 -26767
OR6Y1 -26756
OR4D1 -26737
OR1B1 -26699
OR56A1 -26691
OR8B8 -26689
OR6K2 -26687
OR5W2 -26655
OR5J2 -26648
OR2T5 -26641
OR56B1 -26639
OR1S1 -26635
OR8H2 -26633
OR5B17 -26614
OR14I1 -26595
OR4C46 -26594
OR51F1 -26587
OR2M5 -26579
OR14J1 -26576
OR52E2 -26553
OR1L1 -26548
OR1N1 -26544
OR8U1 -26518
OR13G1 -26513
OR14A2 -26512
OR2AP1 -26510
OR14K1 -26497
OR8B12 -26492
OR4D11 -26491
OR5I1 -26481
OR5B2 -26474
OR10J5 -26471
OR5B21 -26467
OR5AS1 -26464
OR2B11 -26463
OR6N1 -26451
OR2G2 -26428
OR4D9 -26393
OR8B4 -26387
OR8K3 -26383
OR3A2 -26381
OR52E6 -26372
OR52N4 -26355
OR10G8 -26345
OR2T34 -26340
OR5T3 -26329
OR4D10 -26322
OR6F1 -26309
OR51J1 -26302
OR8K5 -26278
OR51B6 -26274
OR4A16 -26270
OR51B5 -26216
OR5B3 -26211
OR5T2 -26199
OR52R1 -26167
OR2F1 -26162
OR2T6 -26133
OR10AG1 -26132
OR51F2 -26110
OR5B12 -26091
OR4D6 -26090
OR10G4 -26076
OR4A47 -26070
OR8H3 -26065
OR10C1 -26063
OR8J1 -26059
OR5P2 -26050
OR2A25 -26047
OR51A7 -26045
OR8A1 -26043
OR4C16 -26039
OR6B1 -26030
OR6N2 -26025
OR11H7 -26024
OR5AU1 -26016
OR51B2 -26008
OR52E4 -26003
OR5M8 -25980
OR5AP2 -25966
OR9G1 -25965
OR11L1 -25958
OR5M3 -25955
OR8J3 -25950
OR12D2 -25903
OR10A5 -25896
OR8D1 -25889
OR4F15 -25863
OR52J3 -25827
OR52H1 -25808
OR9Q2 -25789
OR5AR1 -25784
OR2G3 -25774
OR2T12 -25771
OR2A2 -25748
OR2A4 -25735
OR5F1 -25728
OR52L1 -25709
OR2L8 -25693
OR51T1 -25681
OR4F4 -25666
OR1C1 -25646
OR2AG2 -25645
OR2M3 -25628
OR51I2 -25624
OR10K1 -25600
OR5L1 -25584
OR4A15 -25565
OR2G6 -25557
OR51B4 -25553
OR2W1 -25547
OR2T3 -25531
OR5H15 -25522
OR2T33 -25513
OR6C75 -25511
OR10X1 -25493
OR9G4 -25490
OR6K6 -25483
OR51Q1 -25479
OR52N1 -25470
OR10T2 -25467
OR8B2 -25455
OR4E2 -25445
OR51G2 -25404
OR4C15 -25380
OR5D13 -25372
OR2M2 -25363
OR9A2 -25348
OR14C36 -25346
OR4X2 -25342
OR2W3 -25327
OR51A2 -25317
OR52A1 -25223
OR10S1 -25208
OR14A16 -25197
OR4D5 -25172
OR2B3 -25161
OR2T35 -25160
OR5AK2 -25154
OR10A4 -25147
OR10D3 -25137
OR7G3 -25121
OR10Q1 -25054
OR3A3 -25044
OR52B2 -25043
OR2D2 -25015
OR2J2 -25008
OR52E8 -24969
OR1L6 -24949
OR10R2 -24927
OR5T1 -24925
OR51G1 -24906
OR8K1 -24884
OR5V1 -24874
OR5M9 -24862
OR4C12 -24830
OR1L4 -24822
OR8B3 -24811
OR5L2 -24802
OR51D1 -24757
OR2AT4 -24742
OR4C6 -24737
OR2AE1 -24729
OR5D14 -24686
OR1J2 -24649
OR4S1 -24591
OR9Q1 -24586
OR51E1 -24583
OR52N2 -24577
OR2Z1 -24527
OR5A1 -24509
OR2A12 -24485
OR52B6 -24482
OR12D3 -24430
OR56A4 -24423
OR1K1 -24422
OR8D2 -24418
OR2L2 -24412
OR8I2 -24396
OR56A3 -24384
OR9K2 -24369
OR2J3 -24364
OR5M1 -24348
OR2T2 -24325
OR2T8 -24315
OR4B1 -24302
OR5H2 -24301
ANO2 -24251
OR1L8 -24179
OR5A2 -24172
OR5AN1 -24159
OR4K5 -24157
OR2T1 -24141
OR11A1 -24082
OR2S2 -24078
OR56B4 -24073
OR2Y1 -24055
OR1Q1 -24052
OR4K13 -24050
OR51S1 -24030
OR4F6 -24022
OR5D18 -23989
OR2AJ1 -23942
OR6X1 -23891
OR52I2 -23861
OR52K1 -23825
OR4C5 -23811
OR13D1 -23794
OR1A2 -23769
OR51L1 -23730
OR10A3 -23706
OR10A7 -23683
OR6B2 -23678
OR1M1 -23656
OR6C6 -23592
OR6C74 -23558
OR2T27 -23542
OR4N4 -23484
OR5M11 -23459
OR2K2 -23451
OR51V1 -23432
OR2J1 -23357
OR7C2 -23324
OR4D2 -23304
OR10G7 -23299
OR6C65 -23279
OR5C1 -23263
OR7D4 -23255
OR2H1 -23125
OR6T1 -23103
OR8D4 -23072
OR4K15 -23036
OR2V1 -23029
OR1E2 -22991
OR6C2 -22933
OR1J4 -22923
OR6C1 -22890
OR7G2 -22886
OR5D16 -22863
OR1L3 -22860
OR51M1 -22856
OR2L13 -22832
OR10V1 -22821
OR2D3 -22709
OR10H5 -22698
OR52K2 -22693
OR2AG1 -22630
OR1N2 -22604
OR6K3 -22553
OR2A5 -22532
OR2F2 -22463
OR10G2 -22462
OR51E2 -22440
OR10H3 -22434
OR2AK2 -22422
OR4F5 -22417
OR1D5 -22397
OR52W1 -22296
OR8H1 -22207
OR5P3 -22206
OR7G1 -22137
OR4X1 -22113
OR7A17 -22069
OR6C4 -22031
OR2T4 -22015
OR4M1 -21987
OR13C2 -21981
OR52I1 -21746
OR7E24 -21701
OR6J1 -21535
OR10H4 -21498
OR10H2 -21152
OR52N5 -21021
OR1D2 -20978
OR7D2 -20975
RTP2 -20915
OR10A6 -20823
OR4A5 -20652
OR10P1 -20584
OR2A14 -20581
OR4N2 -20579
OR52M1 -20507
OR10H1 -20346
OR2V2 -20281
OR6A2 -20122
OR1E1 -19980
OR13A1 -19947
OR2L3 -19931
OR11G2 -19918
OR10A2 -19859
OR6C70 -19711
OR4Q3 -19699
OR1J1 -19569
OR6V1 -19505
OR5K3 -19501
OR1F1 -19173
OR4C13 -19153
OR6C3 -19009
OR6C68 -18942
OR13C9 -18921
OR9A4 -18768
OR13J1 -18720
OR5K2 -18542
OR2H2 -18442
OR2C1 -18375
OR4K1 -18347
OR13C3 -18264
OR5M10 -17966
OR5K4 -17914
OR13F1 -17538
REEP1 -17480
OR4L1 -17403
OR6B3 -17400
OR2B6 -17314
ADCY3 -17130
OR6M1 -17083
OR5K1 -17015
OR8S1 -16954
OR4K17 -16924
EBF1 -16910
OR2B2 -16491
OR6S1 -16034
OR13C8 -15760
OR4M2 -15571
OR1A1 -15376
OR1G1 -15049
OR10AD1 -14878
OR10G3 -14801
CNGB1 -14776
OR3A1 -14732
OR2T11 -14600
OR4Q2 -13368
CNGA4 -12546
OR13C4 -12351
OR4K2 -12287
OR1I1 -11628
OR4K14 -10846
OR11H4 -10012
RTP1 -9900
OR2C3 -8616
OR7C1 -7784
GNAL -5571
OR11H6 -2410
OR2A1 -2197
OR4N5 -2180
OR7A10 -1468
GNG13 702
GNB1 3998
LDB1 4099
OR7A5 5213
OR6C76 5608
LHX2 6452


REACTOME_BETA_DEFENSINS

REACTOME_BETA_DEFENSINS
110
set REACTOME_BETA_DEFENSINS
setSize 36
pANOVA 3.73e-14
s.dist -0.729
p.adjustANOVA 2.17e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
DEFB107B -26858
DEFB105B -26590
DEFB105A -26568
DEFB106B -26101
DEFB118 -26036
DEFB135 -25882
DEFB119 -25851
DEFB115 -25770
DEFB116 -25749
DEFB126 -25587
DEFB106A -25566
DEFB114 -25545
DEFB103A -25521
DEFB121 -25229
DEFB104B -25192
DEFB127 -24557
DEFB110 -24236
DEFB125 -24152
DEFB4A -24047
DEFB108B -23922

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DEFB107B -26858
DEFB105B -26590
DEFB105A -26568
DEFB106B -26101
DEFB118 -26036
DEFB135 -25882
DEFB119 -25851
DEFB115 -25770
DEFB116 -25749
DEFB126 -25587
DEFB106A -25566
DEFB114 -25545
DEFB103A -25521
DEFB121 -25229
DEFB104B -25192
DEFB127 -24557
DEFB110 -24236
DEFB125 -24152
DEFB4A -24047
DEFB108B -23922
DEFB128 -23827
DEFB129 -23112
DEFB123 -22494
DEFB104A -22488
DEFB113 -22004
CCR2 -21824
CCR6 -21719
DEFB134 -21632
DEFB4B -21426
DEFB133 -20848
DEFB136 -20746
TLR1 -20006
DEFB132 -18419
TLR2 -14967
DEFB1 -2305
DEFB124 -1751


REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS

REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS
1048
set REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS
setSize 6
pANOVA 0.00218
s.dist -0.722
p.adjustANOVA 0.00796



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A8 -26301
S100A7 -23228
S100A7A -23210
LCN2 -22910
S100A9 -19879
LTF -18655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A8 -26301
S100A7 -23228
S100A7A -23210
LCN2 -22910
S100A9 -19879
LTF -18655


REACTOME_VITAMINS

REACTOME_VITAMINS
428
set REACTOME_VITAMINS
setSize 6
pANOVA 0.00286
s.dist 0.703
p.adjustANOVA 0.00989



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP26C1 5725
CYP26A1 4761
CYP26B1 2903
CYP24A1 2112
CYP27B1 809
CYP2R1 -5436

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP26C1 5725
CYP26A1 4761
CYP26B1 2903
CYP24A1 2112
CYP27B1 809
CYP2R1 -5436


REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION

REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION
523
set REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION
setSize 10
pANOVA 0.00019
s.dist 0.681
p.adjustANOVA 0.00112



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDX2 6692
GSC 6253
EOMES 6219
GATA6 5754
HHEX 2028
DKK1 1310
NANOG 784
POU5F1 725
TSC22D1 -2544
SOX2 -12792

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDX2 6692
GSC 6253
EOMES 6219
GATA6 5754
HHEX 2028
DKK1 1310
NANOG 784
POU5F1 725
TSC22D1 -2544
SOX2 -12792


REACTOME_DEFENSINS

REACTOME_DEFENSINS
111
set REACTOME_DEFENSINS
setSize 45
pANOVA 8.4e-15
s.dist -0.668
p.adjustANOVA 5.26e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
DEFB107B -26858
DEFB105B -26590
DEFB105A -26568
DEFA1 -26339
DEFB106B -26101
DEFB118 -26036
DEFB135 -25882
DEFB119 -25851
DEFB115 -25770
DEFB116 -25749
DEFB126 -25587
DEFB106A -25566
DEFB114 -25545
DEFB103A -25521
DEFB121 -25229
DEFB104B -25192
DEFB127 -24557
DEFB110 -24236
DEFB125 -24152
DEFB4A -24047

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DEFB107B -26858
DEFB105B -26590
DEFB105A -26568
DEFA1 -26339
DEFB106B -26101
DEFB118 -26036
DEFB135 -25882
DEFB119 -25851
DEFB115 -25770
DEFB116 -25749
DEFB126 -25587
DEFB106A -25566
DEFB114 -25545
DEFB103A -25521
DEFB121 -25229
DEFB104B -25192
DEFB127 -24557
DEFB110 -24236
DEFB125 -24152
DEFB4A -24047
DEFB108B -23922
DEFA4 -23901
DEFB128 -23827
DEFB129 -23112
DEFA1B -23034
DEFB123 -22494
DEFB104A -22488
DEFB113 -22004
DEFA5 -21886
DEFA3 -21840
CCR2 -21824
CCR6 -21719
DEFB134 -21632
DEFB4B -21426
DEFB133 -20848
DEFB136 -20746
TLR1 -20006
DEFB132 -18419
ART1 -17476
TLR2 -14967
DEFA6 -13351
CD4 -8684
DEFB1 -2305
DEFB124 -1751
PRSS3 555


REACTOME_ADRENOCEPTORS

REACTOME_ADRENOCEPTORS
655
set REACTOME_ADRENOCEPTORS
setSize 9
pANOVA 0.000625
s.dist 0.658
p.adjustANOVA 0.00287



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADRB3 6307
ADRB1 5506
ADRA1D 5230
ADRA2A 5166
ADRA2C 4576
ADRB2 4198
ADRA1A 1930
ADRA2B -11225
ADRA1B -12211

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADRB3 6307
ADRB1 5506
ADRA1D 5230
ADRA2A 5166
ADRA2C 4576
ADRB2 4198
ADRA1A 1930
ADRA2B -11225
ADRA1B -12211


REACTOME_FBXW7_MUTANTS_AND_NOTCH1_IN_CANCER

REACTOME_FBXW7_MUTANTS_AND_NOTCH1_IN_CANCER
510
set REACTOME_FBXW7_MUTANTS_AND_NOTCH1_IN_CANCER
setSize 5
pANOVA 0.0123
s.dist 0.647
p.adjustANOVA 0.0313



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBX1 2738
NOTCH1 2659
FBXW7 911
CUL1 -389
SKP1 -1635

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBX1 2738
NOTCH1 2659
FBXW7 911
CUL1 -389
SKP1 -1635


REACTOME_G2_PHASE

REACTOME_G2_PHASE
1090
set REACTOME_G2_PHASE
setSize 5
pANOVA 0.0144
s.dist 0.632
p.adjustANOVA 0.0353



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCNA1 5553
CDK2 1941
CCNA2 87
E2F1 -2166
E2F3 -2366

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNA1 5553
CDK2 1941
CCNA2 87
E2F1 -2166
E2F3 -2366


REACTOME_INTERLEUKIN_9_SIGNALING

REACTOME_INTERLEUKIN_9_SIGNALING
1339
set REACTOME_INTERLEUKIN_9_SIGNALING
setSize 7
pANOVA 0.00546
s.dist 0.606
p.adjustANOVA 0.0165



Top enriched genes

Top 20 genes
GeneID Gene Rank
IL9 5988
JAK1 3361
STAT5B 2575
JAK3 1322
STAT5A -349
STAT3 -1684
STAT1 -10001

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL9 5988
JAK1 3361
STAT5B 2575
JAK3 1322
STAT5A -349
STAT3 -1684
STAT1 -10001


REACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD

REACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD
582
set REACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD
setSize 7
pANOVA 0.00551
s.dist 0.606
p.adjustANOVA 0.0166



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHST3 5771
BCAN 4936
CSPG5 2240
NCAN -886
CSPG4 -1040
DCN -2673
VCAN -7220

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHST3 5771
BCAN 4936
CSPG5 2240
NCAN -886
CSPG4 -1040
DCN -2673
VCAN -7220


REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE
300
set REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE
setSize 8
pANOVA 0.00329
s.dist -0.6
p.adjustANOVA 0.0112



Top enriched genes

Top 20 genes
GeneID Gene Rank
AMY1B -26667
AMY2A -23859
CHIA -22162
MGAM -21016
AMY2B -18722
LCT -18273
CHIT1 -16260
TREH -15362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AMY1B -26667
AMY2A -23859
CHIA -22162
MGAM -21016
AMY2B -18722
LCT -18273
CHIT1 -16260
TREH -15362


REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS

REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS
584
set REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS
setSize 7
pANOVA 0.00607
s.dist 0.599
p.adjustANOVA 0.018



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHSY1 4957
BCAN 4936
CSPG5 2240
NCAN -886
CSPG4 -1040
DCN -2673
VCAN -7220

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHSY1 4957
BCAN 4936
CSPG5 2240
NCAN -886
CSPG4 -1040
DCN -2673
VCAN -7220


REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY

REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY
65
set REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY
setSize 9
pANOVA 0.00187
s.dist 0.599
p.adjustANOVA 0.00703



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-B 5142
HLA-G 4549
HLA-C 4343
B2M 3510
HLA-E 3411
HLA-F 1668
HLA-A -513
LNPEP -7373
CTSS -14370

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-B 5142
HLA-G 4549
HLA-C 4343
B2M 3510
HLA-E 3411
HLA-F 1668
HLA-A -513
LNPEP -7373
CTSS -14370


REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS

REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS
810
set REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS
setSize 30
pANOVA 1.68e-08
s.dist 0.595
p.adjustANOVA 3.25e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDX2 6692
PRDM14 6621
GSC 6253
EOMES 6219
LIN28A 6053
SALL1 6037
EPAS1 5944
FOXD3 5924
GATA6 5754
KLF4 5020
HIF3A 3979
FGF2 2764
EPHA1 2500
HHEX 2028
DKK1 1310
SALL4 851
NANOG 784
POU5F1 725
ZSCAN10 132
STAT3 -1684

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDX2 6692
PRDM14 6621
GSC 6253
EOMES 6219
LIN28A 6053
SALL1 6037
EPAS1 5944
FOXD3 5924
GATA6 5754
KLF4 5020
HIF3A 3979
FGF2 2764
EPHA1 2500
HHEX 2028
DKK1 1310
SALL4 851
NANOG 784
POU5F1 725
ZSCAN10 132
STAT3 -1684
SMAD4 -1697
TSC22D1 -2544
NR5A1 -4377
PBX1 -5965
TDGF1 -7645
FOXP1 -8193
NR6A1 -9358
SMAD2 -10296
DPPA4 -11902
SOX2 -12792


REACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS

REACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS
1404
set REACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS
setSize 6
pANOVA 0.0117
s.dist -0.594
p.adjustANOVA 0.0302



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP1A2 -23705
CYP2C8 -22947
CYP3A4 -22664
CYP2C9 -22485
CYP2D6 -15188
CYP2E1 -14142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP1A2 -23705
CYP2C8 -22947
CYP3A4 -22664
CYP2C9 -22485
CYP2D6 -15188
CYP2E1 -14142


REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS

REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS
1386
set REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS
setSize 6
pANOVA 0.0123
s.dist 0.59
p.adjustANOVA 0.0313



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALOX15 4922
PTGS2 2911
HPGD 2214
ALOX5 -2315
LTA4H -3187
GPX4 -5139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX15 4922
PTGS2 2911
HPGD 2214
ALOX5 -2315
LTA4H -3187
GPX4 -5139


REACTOME_ERKS_ARE_INACTIVATED

REACTOME_ERKS_ARE_INACTIVATED
395
set REACTOME_ERKS_ARE_INACTIVATED
setSize 13
pANOVA 0.000277
s.dist 0.582
p.adjustANOVA 0.00148



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1B 5565
DUSP6 4183
MAPK3 3516
DUSP7 3119
PPP2R1A 2355
DUSP4 2033
VRK3 47
MAPK7 -188
PPP2CA -1782
DUSP3 -2562
PPP2CB -4338
MAPK1 -6631
PPP2R5D -8395

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1B 5565
DUSP6 4183
MAPK3 3516
DUSP7 3119
PPP2R1A 2355
DUSP4 2033
VRK3 47
MAPK7 -188
PPP2CA -1782
DUSP3 -2562
PPP2CB -4338
MAPK1 -6631
PPP2R5D -8395


REACTOME_CD22_MEDIATED_BCR_REGULATION

REACTOME_CD22_MEDIATED_BCR_REGULATION
1002
set REACTOME_CD22_MEDIATED_BCR_REGULATION
setSize 53
pANOVA 2.87e-13
s.dist -0.579
p.adjustANOVA 1.42e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV4-1 -27061
IGKV1D-12 -26997
IGKV2D-30 -26888
IGKV3-11 -26835
IGKV1-17 -26817
IGHV3-48 -26559
IGKV1-16 -26541
IGKV1D-16 -26166
IGKV1-5 -26146
IGLV3-25 -25750
IGKV3-15 -25710
IGKV5-2 -25480
CD79A -25457
IGHD -25401
IGHV3-7 -25379
IGHV4-39 -25365
IGKV3-20 -25355
IGHV3-11 -25059
IGKV3D-20 -24112
PTPN6 -23359

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV4-1 -27061.0
IGKV1D-12 -26997.0
IGKV2D-30 -26888.0
IGKV3-11 -26835.0
IGKV1-17 -26817.0
IGHV3-48 -26559.0
IGKV1-16 -26541.0
IGKV1D-16 -26166.0
IGKV1-5 -26146.0
IGLV3-25 -25750.0
IGKV3-15 -25710.0
IGKV5-2 -25480.0
CD79A -25457.0
IGHD -25401.0
IGHV3-7 -25379.0
IGHV4-39 -25365.0
IGKV3-20 -25355.0
IGHV3-11 -25059.0
IGKV3D-20 -24112.0
PTPN6 -23359.0
IGKV2-30 -22816.0
IGLV2-23 -22624.0
IGLV3-1 -22479.0
IGHV1-46 -21726.0
IGLV3-27 -21703.0
CD22 -21433.0
IGHM -21413.0
IGHV3-23 -20814.0
CD79B -20511.0
IGLV2-11 -20488.5
IGHV3-13 -20476.0
IGLV3-21 -20443.0
IGHV2-70 -19320.0
IGLV2-8 -19236.5
IGLV3-19 -19218.0
IGHV2-5 -18846.0
IGLV7-43 -18195.0
IGHV1-69 -17835.0
IGHV4-59 -17725.0
IGHV3-53 -16945.0
IGHV1-2 -16899.0
IGHV3-33 -16165.0
LYN -16115.0
IGHV4-34 -14507.0
IGLC3 -12965.0
IGLC2 -12419.0
IGLV1-44 -12247.0
IGLV1-47 -10868.0
IGKV2-28 -8472.0
IGLV6-57 -6973.0
IGLV1-40 -6371.0
IGLV1-51 -797.0
IGLV2-14 -443.5


REACTOME_ANTIMICROBIAL_PEPTIDES

REACTOME_ANTIMICROBIAL_PEPTIDES
1053
set REACTOME_ANTIMICROBIAL_PEPTIDES
setSize 86
pANOVA 1.94e-20
s.dist -0.577
p.adjustANOVA 2.11e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
DEFB107B -26858
RNASE6 -26794
REG3A -26597
DEFB105B -26590
DEFB105A -26568
DEFA1 -26339
S100A8 -26301
BPIFA1 -26246
SEMG1 -26187
RNASE3 -26147
DEFB106B -26101
DEFB118 -26036
DEFB135 -25882
DEFB119 -25851
REG3G -25847
DEFB115 -25770
DEFB116 -25749
DEFB126 -25587
DEFB106A -25566
DEFB114 -25545

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DEFB107B -26858
RNASE6 -26794
REG3A -26597
DEFB105B -26590
DEFB105A -26568
DEFA1 -26339
S100A8 -26301
BPIFA1 -26246
SEMG1 -26187
RNASE3 -26147
DEFB106B -26101
DEFB118 -26036
DEFB135 -25882
DEFB119 -25851
REG3G -25847
DEFB115 -25770
DEFB116 -25749
DEFB126 -25587
DEFB106A -25566
DEFB114 -25545
DEFB103A -25521
DCD -25442
DEFB121 -25229
DEFB104B -25192
PI3 -24889
DEFB127 -24557
DEFB110 -24236
DEFB125 -24152
DEFB4A -24047
BPIFA2 -23955
DEFB108B -23922
DEFA4 -23901
DEFB128 -23827
BPIFB6 -23796
HTN3 -23273
S100A7 -23228
S100A7A -23210
DEFB129 -23112
DEFA1B -23034
BPIFB4 -22988
LCN2 -22910
DEFB123 -22494
DEFB104A -22488
BPIFB2 -22317
DEFB113 -22004
GNLY -21970
DEFA5 -21886
DEFA3 -21840
CCR2 -21824
CCR6 -21719
DEFB134 -21632
HTN1 -21587
DEFB4B -21426
DEFB133 -20848
DEFB136 -20746
CAMP -20341
TLR1 -20006
S100A9 -19879
PLA2G2A -19717
PRTN3 -19268
LTF -18655
LYZ -18576
CTSG -18486
DEFB132 -18419
BPIFB1 -18408
ART1 -17476
RNASE7 -17020
PGLYRP4 -16608
ELANE -16528
ITLN1 -15590
SLC11A1 -15158
TLR2 -14967
PGLYRP3 -13812
DEFA6 -13351
RNASE8 -13135
CHGA -12800
BPI -11532
CD4 -8684
ATOX1 -6610
PGLYRP2 -3654
DEFB1 -2305
DEFB124 -1751
PRSS3 555
CLU 3441
LEAP2 4783
PGLYRP1 5998


REACTOME_LIGAND_RECEPTOR_INTERACTIONS

REACTOME_LIGAND_RECEPTOR_INTERACTIONS
919
set REACTOME_LIGAND_RECEPTOR_INTERACTIONS
setSize 8
pANOVA 0.00477
s.dist 0.576
p.adjustANOVA 0.0151



Top enriched genes

Top 20 genes
GeneID Gene Rank
SHH 6252
HHIP 4791
DHH 4430
IHH 4421
GAS1 3497
PTCH1 -1733
CDON -12137
BOC -12254

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SHH 6252
HHIP 4791
DHH 4430
IHH 4421
GAS1 3497
PTCH1 -1733
CDON -12137
BOC -12254


REACTOME_RESPONSE_TO_METAL_IONS

REACTOME_RESPONSE_TO_METAL_IONS
962
set REACTOME_RESPONSE_TO_METAL_IONS
setSize 14
pANOVA 0.000195
s.dist 0.575
p.adjustANOVA 0.00114



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT1E 6320
MT1M 5899
MT2A 5372
SNCB 4983
CSRP1 4931
MT1G 4918
MT3 4849
MT1A 4843
MT1X -1276
MT1H -1408
MT1F -4690
MTF1 -5140
MT1B -11434
MT4 -23259

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT1E 6320
MT1M 5899
MT2A 5372
SNCB 4983
CSRP1 4931
MT1G 4918
MT3 4849
MT1A 4843
MT1X -1276
MT1H -1408
MT1F -4690
MTF1 -5140
MT1B -11434
MT4 -23259


REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_ENDOCRINE_COMMITTED_NEUROG3_PROGENITOR_CELLS

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_ENDOCRINE_COMMITTED_NEUROG3_PROGENITOR_CELLS
420
set REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_ENDOCRINE_COMMITTED_NEUROG3_PROGENITOR_CELLS
setSize 5
pANOVA 0.0278
s.dist 0.568
p.adjustANOVA 0.059



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEUROD1 6354
INSM1 5130
NKX2-2 5125
NEUROG3 4586
PAX4 -23583

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEUROD1 6354
INSM1 5130
NKX2-2 5125
NEUROG3 4586
PAX4 -23583


REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR
59
set REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR
setSize 11
pANOVA 0.0012
s.dist 0.564
p.adjustANOVA 0.00485



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPAS1 5944
EPO 5714
HIGD1A 4231
HIF3A 3979
VEGFA 2308
CREBBP 1997
CITED2 354
CA9 -482
EP300 -5855
ARNT -6578
HIF1A -17619

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPAS1 5944
EPO 5714
HIGD1A 4231
HIF3A 3979
VEGFA 2308
CREBBP 1997
CITED2 354
CA9 -482
EP300 -5855
ARNT -6578
HIF1A -17619


REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS
896
set REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS
setSize 56
pANOVA 3.61e-13
s.dist 0.561
p.adjustANOVA 1.68e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
HOXD4 6825
HOXB1 6778
HOXA2 6736
HOXA3 6707
HOXA4 6705
HOXD3 6689
HOXB4 6644
HOXB2 6565
PAX6 6549
HOXB3 6273
HOXC4 5820
RARA 5679
MEIS1 5633
HOXD1 5591
RARG 5305
POLR2C 5112
MAFB 4768
PCGF2 4086
POLR2L 3674
AJUBA 3579

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HOXD4 6825
HOXB1 6778
HOXA2 6736
HOXA3 6707
HOXA4 6705
HOXD3 6689
HOXB4 6644
HOXB2 6565
PAX6 6549
HOXB3 6273
HOXC4 5820
RARA 5679
MEIS1 5633
HOXD1 5591
RARG 5305
POLR2C 5112
MAFB 4768
PCGF2 4086
POLR2L 3674
AJUBA 3579
POLR2A 3132
CREBBP 1997
YY1 1804
WDR5 1489
JUN 24
POLR2I -455
ASH2L -594
RBBP5 -806
NCOA3 -1091
CTCF -1092
RBBP4 -1519
POLR2B -1562
POLR2J -1951
ZNF335 -2357
POLR2E -2394
CNOT6 -2535
EED -2816
HDAC3 -2938
HOXA1 -3243
PAXIP1 -4474
POLR2K -4581
POLR2H -4998
POLR2D -5773
EP300 -5855
PBX1 -5965
RARB -7351
PKNOX1 -7473
EGR2 -7605
RXRA -7948
SUZ12 -8580
PIAS2 -9001
POLR2G -9254
NCOR1 -9528
POLR2F -10294
EZH2 -11331
NCOA6 -12893


REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5

REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5
1402
set REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5
setSize 7
pANOVA 0.0106
s.dist 0.558
p.adjustANOVA 0.0278



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPO 5714
EPOR 4818
IRS2 2724
STAT5B 2575
STAT5A -349
JAK2 -3906
LYN -16115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPO 5714
EPOR 4818
IRS2 2724
STAT5B 2575
STAT5A -349
JAK2 -3906
LYN -16115


REACTOME_CS_DS_DEGRADATION

REACTOME_CS_DS_DEGRADATION
392
set REACTOME_CS_DS_DEGRADATION
setSize 12
pANOVA 0.000867
s.dist 0.555
p.adjustANOVA 0.00376



Top enriched genes

Top 20 genes
GeneID Gene Rank
BCAN 4936
HYAL1 4834
CSPG5 2240
HYAL3 2124
ARSB -340
NCAN -886
CSPG4 -1040
IDUA -2382
DCN -2673
HEXB -3736
HEXA -4232
VCAN -7220

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BCAN 4936
HYAL1 4834
CSPG5 2240
HYAL3 2124
ARSB -340
NCAN -886
CSPG4 -1040
IDUA -2382
DCN -2673
HEXB -3736
HEXA -4232
VCAN -7220


REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS
418
set REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS
setSize 15
pANOVA 0.000211
s.dist 0.552
p.adjustANOVA 0.0012



Top enriched genes

Top 20 genes
GeneID Gene Rank
ONECUT1 6430
ONECUT3 5631
HNF1B 4885
NEUROG3 4586
NOTCH1 2659
KAT2B 2031
CREBBP 1997
SNW1 1952
HES1 -2088
MAML1 -2390
KAT2A -4799
EP300 -5855
MAML2 -6384
RBPJ -6427
MAML3 -13394

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ONECUT1 6430
ONECUT3 5631
HNF1B 4885
NEUROG3 4586
NOTCH1 2659
KAT2B 2031
CREBBP 1997
SNW1 1952
HES1 -2088
MAML1 -2390
KAT2A -4799
EP300 -5855
MAML2 -6384
RBPJ -6427
MAML3 -13394


REACTOME_METALLOTHIONEINS_BIND_METALS

REACTOME_METALLOTHIONEINS_BIND_METALS
964
set REACTOME_METALLOTHIONEINS_BIND_METALS
setSize 11
pANOVA 0.0018
s.dist 0.543
p.adjustANOVA 0.00688



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT1E 6320
MT1M 5899
MT2A 5372
MT1G 4918
MT3 4849
MT1A 4843
MT1X -1276
MT1H -1408
MT1F -4690
MT1B -11434
MT4 -23259

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT1E 6320
MT1M 5899
MT2A 5372
MT1G 4918
MT3 4849
MT1A 4843
MT1X -1276
MT1H -1408
MT1F -4690
MT1B -11434
MT4 -23259


REACTOME_RHO_GTPASES_ACTIVATE_ROCKS

REACTOME_RHO_GTPASES_ACTIVATE_ROCKS
916
set REACTOME_RHO_GTPASES_ACTIVATE_ROCKS
setSize 19
pANOVA 4.34e-05
s.dist 0.542
p.adjustANOVA 0.000326



Top enriched genes

Top 20 genes
GeneID Gene Rank
RHOB 5838
MYL9 4920
MYH9 4865
MYH14 3373
MYL6 2800
RHOC 2405
ROCK2 2143
PPP1R12B 867
ROCK1 674
CFL1 -329
PPP1R12A -765
LIMK2 -1059
LIMK1 -1102
MYH10 -2740
RHOA -5133
MYH11 -6058
PPP1CB -6414
MYL12B -8034
PAK1 -13890

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RHOB 5838
MYL9 4920
MYH9 4865
MYH14 3373
MYL6 2800
RHOC 2405
ROCK2 2143
PPP1R12B 867
ROCK1 674
CFL1 -329
PPP1R12A -765
LIMK2 -1059
LIMK1 -1102
MYH10 -2740
RHOA -5133
MYH11 -6058
PPP1CB -6414
MYL12B -8034
PAK1 -13890


REACTOME_SIGNALING_BY_RNF43_MUTANTS

REACTOME_SIGNALING_BY_RNF43_MUTANTS
857
set REACTOME_SIGNALING_BY_RNF43_MUTANTS
setSize 8
pANOVA 0.0089
s.dist 0.534
p.adjustANOVA 0.0242



Top enriched genes

Top 20 genes
GeneID Gene Rank
WNT3A 6309
FZD8 4600
FZD4 3508
FZD5 2762
LRP6 77
RNF43 -3859
LRP5 -9145
FZD6 -12688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT3A 6309
FZD8 4600
FZD4 3508
FZD5 2762
LRP6 77
RNF43 -3859
LRP5 -9145
FZD6 -12688


REACTOME_LIPID_PARTICLE_ORGANIZATION

REACTOME_LIPID_PARTICLE_ORGANIZATION
1329
set REACTOME_LIPID_PARTICLE_ORGANIZATION
setSize 6
pANOVA 0.0239
s.dist 0.532
p.adjustANOVA 0.0526



Top enriched genes

Top 20 genes
GeneID Gene Rank
CIDEA 4150
FITM1 3826
HSD17B13 3639
HILPDA 1989
FITM2 -8028
CIDEC -12062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CIDEA 4150
FITM1 3826
HSD17B13 3639
HILPDA 1989
FITM2 -8028
CIDEC -12062


REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION
821
set REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION
setSize 21
pANOVA 2.96e-05
s.dist 0.526
p.adjustANOVA 0.000237



Top enriched genes

Top 20 genes
GeneID Gene Rank
WNT3A 6309
RSPO1 5942
RSPO4 5894
ZNRF3 5074
RSPO3 4723
FZD8 4600
UBB 3591
FZD4 3508
FZD5 2762
RSPO2 1405
LRP6 77
RNF43 -3859
UBC -3961
USP8 -4541
LGR5 -5234
UBA52 -6581
LGR6 -7464
RPS27A -7647
LGR4 -7749
LRP5 -9145

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT3A 6309
RSPO1 5942
RSPO4 5894
ZNRF3 5074
RSPO3 4723
FZD8 4600
UBB 3591
FZD4 3508
FZD5 2762
RSPO2 1405
LRP6 77
RNF43 -3859
UBC -3961
USP8 -4541
LGR5 -5234
UBA52 -6581
LGR6 -7464
RPS27A -7647
LGR4 -7749
LRP5 -9145
FZD6 -12688


REACTOME_NOSTRIN_MEDIATED_ENOS_TRAFFICKING

REACTOME_NOSTRIN_MEDIATED_ENOS_TRAFFICKING
403
set REACTOME_NOSTRIN_MEDIATED_ENOS_TRAFFICKING
setSize 5
pANOVA 0.0422
s.dist 0.525
p.adjustANOVA 0.0824



Top enriched genes

Top 20 genes
GeneID Gene Rank
CAV1 5224
DNM2 2630
NOSTRIN 5
WASL -5431
NOS3 -8493

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAV1 5224
DNM2 2630
NOSTRIN 5
WASL -5431
NOS3 -8493


REACTOME_FLT3_SIGNALING_BY_CBL_MUTANTS

REACTOME_FLT3_SIGNALING_BY_CBL_MUTANTS
1563
set REACTOME_FLT3_SIGNALING_BY_CBL_MUTANTS
setSize 7
pANOVA 0.0163
s.dist 0.524
p.adjustANOVA 0.0393



Top enriched genes

Top 20 genes
GeneID Gene Rank
CBL 3851
UBB 3591
FLT3LG 3393
FLT3 -1178
UBC -3961
UBA52 -6581
RPS27A -7647

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CBL 3851
UBB 3591
FLT3LG 3393
FLT3 -1178
UBC -3961
UBA52 -6581
RPS27A -7647


REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION

REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION
401
set REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION
setSize 14
pANOVA 0.000684
s.dist 0.524
p.adjustANOVA 0.00308



Top enriched genes

Top 20 genes
GeneID Gene Rank
TBX5 6598
NKX2-5 6297
GATA4 4914
TEAD2 4351
KAT2B 2031
HIPK1 1561
WWTR1 -37
NPPA -1588
TEAD3 -3131
HIPK2 -5597
YAP1 -6203
RUNX2 -6988
TEAD4 -8233
TEAD1 -11128

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TBX5 6598
NKX2-5 6297
GATA4 4914
TEAD2 4351
KAT2B 2031
HIPK1 1561
WWTR1 -37
NPPA -1588
TEAD3 -3131
HIPK2 -5597
YAP1 -6203
RUNX2 -6988
TEAD4 -8233
TEAD1 -11128


REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE
345
set REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE
setSize 16
pANOVA 0.000289
s.dist 0.523
p.adjustANOVA 0.00154



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1B 5565
FRAT1 4087
PPP2R1A 2355
PPP2R5A 2217
PPP2R5B 1681
CSNK1A1 1273
PPP2R5E 729
APC -1391
PPP2CA -1782
PPP2R5C -2475
FRAT2 -2689
GSK3B -3528
PPP2CB -4338
CTNNB1 -4457
PPP2R5D -8395
AXIN1 -8661

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1B 5565
FRAT1 4087
PPP2R1A 2355
PPP2R5A 2217
PPP2R5B 1681
CSNK1A1 1273
PPP2R5E 729
APC -1391
PPP2CA -1782
PPP2R5C -2475
FRAT2 -2689
GSK3B -3528
PPP2CB -4338
CTNNB1 -4457
PPP2R5D -8395
AXIN1 -8661


REACTOME_NADE_MODULATES_DEATH_SIGNALLING

REACTOME_NADE_MODULATES_DEATH_SIGNALLING
410
set REACTOME_NADE_MODULATES_DEATH_SIGNALLING
setSize 5
pANOVA 0.0434
s.dist 0.521
p.adjustANOVA 0.084



Top enriched genes

Top 20 genes
GeneID Gene Rank
CASP3 4013
NGFR 2426
YWHAE 1788
CASP2 -4812
NGF -9752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 4013
NGFR 2426
YWHAE 1788
CASP2 -4812
NGF -9752


REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS
215
set REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS
setSize 63
pANOVA 8.36e-13
s.dist -0.521
p.adjustANOVA 3.5e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV4-1 -27061
IGKV1D-12 -26997
IGKV2D-30 -26888
IGKV3-11 -26835
IGKV1-17 -26817
CRP -26684
IGHV3-48 -26559
IGKV1-16 -26541
IGKV1D-16 -26166
IGKV1-5 -26146
FCN1 -25844
IGLV3-25 -25750
IGKV3-15 -25710
IGHG4 -25591
IGKV5-2 -25480
IGHV3-7 -25379
IGHV4-39 -25365
IGKV3-20 -25355
IGHV3-11 -25059
IGHG2 -24506

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV4-1 -27061.0
IGKV1D-12 -26997.0
IGKV2D-30 -26888.0
IGKV3-11 -26835.0
IGKV1-17 -26817.0
CRP -26684.0
IGHV3-48 -26559.0
IGKV1-16 -26541.0
IGKV1D-16 -26166.0
IGKV1-5 -26146.0
FCN1 -25844.0
IGLV3-25 -25750.0
IGKV3-15 -25710.0
IGHG4 -25591.0
IGKV5-2 -25480.0
IGHV3-7 -25379.0
IGHV4-39 -25365.0
IGKV3-20 -25355.0
IGHV3-11 -25059.0
IGHG2 -24506.0
MBL2 -24444.0
IGKV3D-20 -24112.0
IGHG1 -23491.0
IGKV2-30 -22816.0
IGLV2-23 -22624.0
IGLV3-1 -22479.0
C1QC -22030.0
IGHV1-46 -21726.0
IGLV3-27 -21703.0
COLEC10 -21696.0
IGHV3-23 -20814.0
MASP2 -20565.0
IGLV2-11 -20488.5
IGHV3-13 -20476.0
IGLV3-21 -20443.0
C1QA -20351.0
IGHV2-70 -19320.0
IGLV2-8 -19236.5
IGLV3-19 -19218.0
IGHV2-5 -18846.0
MASP1 -18687.0
IGLV7-43 -18195.0
IGHV1-69 -17835.0
IGHV4-59 -17725.0
IGHV3-53 -16945.0
IGHV1-2 -16899.0
C1QB -16743.0
IGHV3-33 -16165.0
IGHV4-34 -14507.0
FCN2 -14037.0
IGLC3 -12965.0
IGLC2 -12419.0
IGLV1-44 -12247.0
IGLV1-47 -10868.0
COLEC11 -9643.0
IGKV2-28 -8472.0
IGLV6-57 -6973.0
IGLV1-40 -6371.0
C1S -4467.0
IGLV1-51 -797.0
IGLV2-14 -443.5
C1R 2062.0
FCN3 6314.0


REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS

REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS
553
set REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS
setSize 20
pANOVA 5.61e-05
s.dist 0.52
p.adjustANOVA 0.000407



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFAP2B 6766
FOXL2 5473
CDKN2A 5275
TFAP2C 5055
TFAP2A 4444
PIAS1 3447
PIAS4 1172
SUMO1 -892
SP3 -1179
MTA1 -1387
PIAS3 -1918
TP53BP1 -2215
MDM2 -2760
UBE2I -3490
TP53 -3641
HIC1 -5035
SUMO3 -5475
PIAS2 -9001
SUMO2 -9364
MITF -11131

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFAP2B 6766
FOXL2 5473
CDKN2A 5275
TFAP2C 5055
TFAP2A 4444
PIAS1 3447
PIAS4 1172
SUMO1 -892
SP3 -1179
MTA1 -1387
PIAS3 -1918
TP53BP1 -2215
MDM2 -2760
UBE2I -3490
TP53 -3641
HIC1 -5035
SUMO3 -5475
PIAS2 -9001
SUMO2 -9364
MITF -11131


REACTOME_PROSTANOID_LIGAND_RECEPTORS

REACTOME_PROSTANOID_LIGAND_RECEPTORS
661
set REACTOME_PROSTANOID_LIGAND_RECEPTORS
setSize 9
pANOVA 0.00697
s.dist 0.519
p.adjustANOVA 0.02



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTGIR 5819
PTGER2 5330
PTGDR 4456
PTGER1 4399
PTGDR2 2791
TBXA2R 2508
PTGER4 -8568
PTGFR -12681
PTGER3 -15790

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGIR 5819
PTGER2 5330
PTGDR 4456
PTGER1 4399
PTGDR2 2791
TBXA2R 2508
PTGER4 -8568
PTGFR -12681
PTGER3 -15790


REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_PI3K

REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_PI3K
1405
set REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_PI3K
setSize 7
pANOVA 0.0175
s.dist 0.519
p.adjustANOVA 0.0414



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIK3R1 5150
GAB1 2930
NTRK2 2104
BDNF 1588
PIK3CA -2570
NTF4 -7256
GRB2 -11144

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3R1 5150
GAB1 2930
NTRK2 2104
BDNF 1588
PIK3CA -2570
NTF4 -7256
GRB2 -11144


REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS

REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS
1241
set REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS
setSize 10
pANOVA 0.00453
s.dist 0.518
p.adjustANOVA 0.0144



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFAP2B 6766
TFAP2D 5843
TFAP2C 5055
KCTD15 4802
TFAP2A 4444
SUMO1 -892
TFAP2E -3401
UBE2I -3490
KCTD1 -15187
WWOX -17155

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFAP2B 6766
TFAP2D 5843
TFAP2C 5055
KCTD15 4802
TFAP2A 4444
SUMO1 -892
TFAP2E -3401
UBE2I -3490
KCTD1 -15187
WWOX -17155


REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION
544
set REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION
setSize 5
pANOVA 0.0449
s.dist 0.518
p.adjustANOVA 0.0861



Top enriched genes

Top 20 genes
GeneID Gene Rank
LRRFIP1 3090
CREBBP 1997
IRF3 -1407
CTNNB1 -4457
EP300 -5855

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LRRFIP1 3090
CREBBP 1997
IRF3 -1407
CTNNB1 -4457
EP300 -5855


REACTOME_SENSORY_PERCEPTION

REACTOME_SENSORY_PERCEPTION
1569
set REACTOME_SENSORY_PERCEPTION
setSize 576
pANOVA 6.7e-100
s.dist -0.513
p.adjustANOVA 5.46e-97



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR6Q1 -27075
OR9I1 -27072
OR1S2 -27041
OR51I1 -27031
OR2T29 -27025
OR10W1 -27007
OR5H6 -27002
TAS2R1 -26986
OR5H1 -26981
OR10K2 -26949
TAS2R16 -26942
OR10J3 -26927
OR52D1 -26926
OR2M7 -26892
OR2M4 -26891
OR4C3 -26890
OR10Z1 -26873
OR52A5 -26870
OR5AC2 -26867
OR10G9 -26861

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR6Q1 -27075
OR9I1 -27072
OR1S2 -27041
OR51I1 -27031
OR2T29 -27025
OR10W1 -27007
OR5H6 -27002
TAS2R1 -26986
OR5H1 -26981
OR10K2 -26949
TAS2R16 -26942
OR10J3 -26927
OR52D1 -26926
OR2M7 -26892
OR2M4 -26891
OR4C3 -26890
OR10Z1 -26873
OR52A5 -26870
OR5AC2 -26867
OR10G9 -26861
OR5H14 -26853
OR6P1 -26791
OR10J1 -26778
OR2L5 -26767
OR6Y1 -26756
OR4D1 -26737
OR1B1 -26699
OR56A1 -26691
OR8B8 -26689
OR6K2 -26687
OR5W2 -26655
OR5J2 -26648
OR2T5 -26641
OR56B1 -26639
OR1S1 -26635
OR8H2 -26633
OR5B17 -26614
OR14I1 -26595
OR4C46 -26594
OR51F1 -26587
OR2M5 -26579
OR14J1 -26576
OR52E2 -26553
OR1L1 -26548
OR1N1 -26544
OR8U1 -26518
OR13G1 -26513
OR14A2 -26512
OR2AP1 -26510
OR14K1 -26497
OR8B12 -26492
OR4D11 -26491
OR5I1 -26481
OR5B2 -26474
OR10J5 -26471
OR5B21 -26467
OR5AS1 -26464
OR2B11 -26463
OR6N1 -26451
OR2G2 -26428
OR4D9 -26393
OR8B4 -26387
OR8K3 -26383
OR3A2 -26381
OR52E6 -26372
OR52N4 -26355
OR10G8 -26345
OR2T34 -26340
OR5T3 -26329
OR4D10 -26322
OR6F1 -26309
OR51J1 -26302
GRXCR1 -26299
OR8K5 -26278
OR51B6 -26274
OR4A16 -26270
OR51B5 -26216
OR5B3 -26211
OR5T2 -26199
OR52R1 -26167
OR2F1 -26162
OR2T6 -26133
OR10AG1 -26132
OR51F2 -26110
OR5B12 -26091
OR4D6 -26090
OR10G4 -26076
OR4A47 -26070
OR8H3 -26065
OR10C1 -26063
OR8J1 -26059
OR5P2 -26050
OR2A25 -26047
OR51A7 -26045
OR8A1 -26043
OR4C16 -26039
OR6B1 -26030
OR6N2 -26025
OR11H7 -26024
OR5AU1 -26016
OR51B2 -26008
OR52E4 -26003
OR5M8 -25980
OR5AP2 -25966
OR9G1 -25965
OR11L1 -25958
OR5M3 -25955
OR8J3 -25950
OR12D2 -25903
OR10A5 -25896
OR8D1 -25889
OR4F15 -25863
OR52J3 -25827
OR52H1 -25808
OR9Q2 -25789
OR5AR1 -25784
OR2G3 -25774
OR2T12 -25771
OR2A2 -25748
OR2A4 -25735
OR5F1 -25728
OR52L1 -25709
OR2L8 -25693
OR51T1 -25681
OR4F4 -25666
OR1C1 -25646
OR2AG2 -25645
OR2M3 -25628
OR51I2 -25624
OR10K1 -25600
OR5L1 -25584
OR4A15 -25565
OR2G6 -25557
OR51B4 -25553
OR2W1 -25547
OR2T3 -25531
OR5H15 -25522
OR2T33 -25513
OR6C75 -25511
OR10X1 -25493
OR9G4 -25490
OR6K6 -25483
OR51Q1 -25479
OR52N1 -25470
OR10T2 -25467
OR8B2 -25455
OR4E2 -25445
OR51G2 -25404
OR4C15 -25380
OR5D13 -25372
OR2M2 -25363
OR9A2 -25348
OR14C36 -25346
OR4X2 -25342
OR2W3 -25327
OR51A2 -25317
OR52A1 -25223
XIRP2 -25210
OR10S1 -25208
OR14A16 -25197
OR4D5 -25172
OR2B3 -25161
OR2T35 -25160
OR5AK2 -25154
OR10A4 -25147
OR10D3 -25137
OR7G3 -25121
OR10Q1 -25054
OR3A3 -25044
OR52B2 -25043
SDR9C7 -25023
OR2D2 -25015
OR2J2 -25008
OR52E8 -24969
OR1L6 -24949
OR10R2 -24927
OR5T1 -24925
OR51G1 -24906
OR8K1 -24884
OR5V1 -24874
OR5M9 -24862
OR4C12 -24830
OR1L4 -24822
OR8B3 -24811
OR5L2 -24802
OR51D1 -24757
OR2AT4 -24742
OR4C6 -24737
OR2AE1 -24729
OR5D14 -24686
OR1J2 -24649
OR4S1 -24591
OR9Q1 -24586
OR51E1 -24583
OR52N2 -24577
TAS2R39 -24547
OR2Z1 -24527
OR5A1 -24509
OR2A12 -24485
OR52B6 -24482
OR12D3 -24430
OR56A4 -24423
OR1K1 -24422
OR8D2 -24418
OR2L2 -24412
GUCA1C -24404
OR8I2 -24396
OR56A3 -24384
OR9K2 -24369
OR2J3 -24364
OR5M1 -24348
OR2T2 -24325
TAS2R41 -24318
OR2T8 -24315
TAS2R40 -24313
OR4B1 -24302
OR5H2 -24301
ANO2 -24251
OR1L8 -24179
OR5A2 -24172
OR5AN1 -24159
OR4K5 -24157
OR2T1 -24141
OR11A1 -24082
OR2S2 -24078
OR56B4 -24073
OR2Y1 -24055
OR1Q1 -24052
OR4K13 -24050
RHO -24038
OR51S1 -24030
OR4F6 -24022
OR5D18 -23989
OR2AJ1 -23942
OR6X1 -23891
OR52I2 -23861
OR52K1 -23825
OR4C5 -23811
OR13D1 -23794
OR1A2 -23769
APOA4 -23758
OR51L1 -23730
OR10A3 -23706
OR10A7 -23683
OR6B2 -23678
OR1M1 -23656
OR6C6 -23592
OR6C74 -23558
OR2T27 -23542
OR4N4 -23484
OR5M11 -23459
OR2K2 -23451
OR51V1 -23432
OR2J1 -23357
OR7C2 -23324
OR4D2 -23304
OR10G7 -23299
OR6C65 -23279
OR5C1 -23263
OR7D4 -23255
OR2H1 -23125
OR6T1 -23103
OR8D4 -23072
OR4K15 -23036
OR2V1 -23029
OR1E2 -22991
GNAT3 -22953
OR6C2 -22933
OR1J4 -22923
OR6C1 -22890
OR7G2 -22886
OR5D16 -22863
OR1L3 -22860
OR51M1 -22856
OR2L13 -22832
OR10V1 -22821
TAS2R38 -22779
TRPM5 -22750
OR2D3 -22709
OR10H5 -22698
OR52K2 -22693
OR2AG1 -22630
OR1N2 -22604
OR6K3 -22553
OR2A5 -22532
OR2F2 -22463
OR10G2 -22462
OR51E2 -22440
OR10H3 -22434
OR2AK2 -22422
OR4F5 -22417
OR1D5 -22397
PNLIP -22304
OR52W1 -22296
TAS2R46 -22256
OR8H1 -22207
OR5P3 -22206
TAS2R20 -22190
AKR1B10 -22144
OR7G1 -22137
OR4X1 -22113
AKR1C1 -22086
OR7A17 -22069
OR6C4 -22031
OR2T4 -22015
OR4M1 -21987
OR13C2 -21981
GRK7 -21845
OR52I1 -21746
RBP3 -21729
OR7E24 -21701
TAS1R2 -21584
OR6J1 -21535
OR10H4 -21498
RDH16 -21325
OR10H2 -21152
OR52N5 -21021
TAS2R30 -21000
USH1C -20986
OR1D2 -20978
OR7D2 -20975
RTP2 -20915
RDH8 -20829
OR10A6 -20823
OR4A5 -20652
TAS2R8 -20602
OR10P1 -20584
OR2A14 -20581
OR4N2 -20579
OTOG -20530
OR52M1 -20507
TAS2R10 -20406
OR10H1 -20346
OR2V2 -20281
SCN2A -20277
OR6A2 -20122
OR1E1 -19980
OR13A1 -19947
OR2L3 -19931
OR11G2 -19918
OR10A2 -19859
OR6C70 -19711
OR4Q3 -19699
TAS2R50 -19623
OR1J1 -19569
OR6V1 -19505
OR5K3 -19501
TAS2R7 -19381
RPE65 -19368
TTR -19344
CLIC5 -19202
OR1F1 -19173
OR4C13 -19153
TAS2R5 -19078
CALHM3 -19027
OR6C3 -19009
GPC5 -19008
DHRS9 -18980
OR6C68 -18942
OR13C9 -18921
PCDH15 -18856
OR9A4 -18768
OR13J1 -18720
SDC3 -18685
GUCA1B -18668
APOB -18644
ESPNL -18621
RDH12 -18594
RGS9 -18563
PLB1 -18558
OR5K2 -18542
CACNA2D2 -18466
OR2H2 -18442
GRXCR2 -18431
OR2C1 -18375
OR4K1 -18347
OPN1SW -18309
OR13C3 -18264
APOC2 -18157
APOC3 -18059
OTOGL -18027
TAS2R43 -17968
OR5M10 -17966
CALHM1 -17953
SCN3A -17916
OR5K4 -17914
SCNN1D -17901
GPIHBP1 -17870
RBP2 -17708
GPC1 -17545
OR13F1 -17538
TAS2R3 -17491
REEP1 -17480
OR4L1 -17403
OR6B3 -17400
OR2B6 -17314
RLBP1 -17264
RCVRN -17198
ADCY3 -17130
OR6M1 -17083
CABP2 -17031
OR5K1 -17015
OR8S1 -16954
CDH23 -16928
OR4K17 -16924
EBF1 -16910
AKR1C3 -16694
MYO7A -16583
OR2B2 -16491
GNAT1 -16416
TAS2R31 -16264
OR6S1 -16034
CNGA1 -16002
BSN -15997
TAS1R3 -15961
SDC1 -15930
STRA6 -15910
OR13C8 -15760
GNB3 -15593
OR4M2 -15571
KCNMB1 -15549
OR1A1 -15376
PCLO -15213
OR1G1 -15049
AGRN -14995
OR10AD1 -14878
OR10G3 -14801
CNGB1 -14776
SCNN1A -14746
OR3A1 -14732
LRP1 -14652
NAPEPLD -14619
OR2T11 -14600
TAS2R4 -14547
ATP2B2 -14515
LRP2 -14478
SCN2B -14460
TAS2R14 -14312
GRK4 -14057
MYO3B -13922
OTOF -13678
LHFPL5 -13468
CIB2 -13422
OR4Q2 -13368
GPC2 -13338
TMC1 -13111
PRKCQ -12970
LRP12 -12825
GUCA1A -12643
CNGA4 -12546
SNAP25 -12374
OR13C4 -12351
CABP1 -12317
OR4K2 -12287
EPS8 -12281
HSPG2 -11900
STX1A -11709
PLS1 -11698
FNTB -11692
OR1I1 -11628
SDC4 -11155
AKR1C4 -10969
ABCA4 -10931
EPB41L1 -10891
OR4K14 -10846
CAMKMT -10806
SCN9A -10621
KCNMA1 -10551
SCNN1B -10059
OR11H4 -10012
PDE6A -9939
RTP1 -9900
FNTA -9617
RAB3A -9500
RDH11 -9494
METAP1 -9294
HSD17B1 -9180
GNGT1 -9159
RETSAT -9053
SAG -8983
TWF2 -8722
OR2C3 -8616
STRC -8339
RDH10 -8292
CHRNA9 -8265
DNAJC5 -8242
EZR -8015
TAS2R13 -7945
SCN4B -7939
KCNQ4 -7886
OR7C1 -7784
APOA1 -7772
SCN1B -7745
EPB41L3 -7662
BCO2 -7587
PRKCA -7543
GSN -7503
KCNN2 -7054
ATP2B1 -6983
CACNB2 -6963
TWF1 -6854
SCNN1G -6727
CALM1 -6273
SDC2 -6139
LRP8 -6128
SLC17A8 -5923
RBP1 -5871
GRM4 -5852
ACTB -5763
MYO15A -5646
GNAL -5571
CHRNA10 -5520
CAPZA1 -5325
CACNA1D -5281
NMT2 -5174
KCNJ2 -5168
SLC26A5 -5044
ITPR3 -5029
DHRS3 -4925
TRIOBP -4905
TPRN -4499
RDX -4271
LPL -4118
APOE -3951
APOM -3787
EPS8L2 -3582
GRK1 -2842
ACTG1 -2579
CYP4V2 -2524
OR11H6 -2410
PDE6B -2219
OR2A1 -2197
OR4N5 -2180
METAP2 -1993
NMT1 -1680
OR7A10 -1468
PLCB2 -1403
APOA2 -1397
TMIE -1337
GNB5 -1201
MYO3A -1193
CTBP2 -535
TMC2 -369
SLC24A1 -289
GPC6 254
GNG13 702
CAPZA2 716
HSD17B6 732
GUCY2D 1026
LRP10 1080
PDE6G 1409
FSCN2 2484
LDLR 2825
CAPZB 3288
MYO1C 3414
RDH5 3444
TRPM4 3491
TAS1R1 3536
RGS9BP 3658
CLPS 3996
GNB1 3998
LDB1 4099
SPTAN1 4475
USH1G 4515
MYH9 4865
SPTBN1 4908
RBP4 4926
OTOP1 5010
VAMP2 5090
GRM1 5212
OR7A5 5213
LRRC52 5364
LRAT 5491
OR6C76 5608
ESPN 5872
LHX2 6452


REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE

REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE
583
set REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE
setSize 7
pANOVA 0.0188
s.dist 0.513
p.adjustANOVA 0.044



Top enriched genes

Top 20 genes
GeneID Gene Rank
BCAN 4936
CSPG5 2240
NCAN -886
CSPG4 -1040
DCN -2673
CHST14 -5254
VCAN -7220

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BCAN 4936
CSPG5 2240
NCAN -886
CSPG4 -1040
DCN -2673
CHST14 -5254
VCAN -7220


REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS

REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS
826
set REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS
setSize 14
pANOVA 0.00102
s.dist 0.507
p.adjustANOVA 0.0043



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1B 5565
PPP2R1A 2355
PPP2R5A 2217
PPP2R5B 1681
CSNK1A1 1273
PPP2R5E 729
APC -1391
PPP2CA -1782
PPP2R5C -2475
GSK3B -3528
PPP2CB -4338
CTNNB1 -4457
PPP2R5D -8395
AXIN1 -8661

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1B 5565
PPP2R1A 2355
PPP2R5A 2217
PPP2R5B 1681
CSNK1A1 1273
PPP2R5E 729
APC -1391
PPP2CA -1782
PPP2R5C -2475
GSK3B -3528
PPP2CB -4338
CTNNB1 -4457
PPP2R5D -8395
AXIN1 -8661


REACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING

REACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING
742
set REACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING
setSize 8
pANOVA 0.0132
s.dist 0.506
p.adjustANOVA 0.0331



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLIT2 4737
ABL1 3389
ROBO1 2528
CLASP2 585
CAP2 -518
CAP1 -5389
ABL2 -7671
CLASP1 -9906

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLIT2 4737
ABL1 3389
ROBO1 2528
CLASP2 585
CAP2 -518
CAP1 -5389
ABL2 -7671
CLASP1 -9906


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gplots_3.1.3                                       
##  [6] gtools_3.9.4                                       
##  [7] tibble_3.2.1                                       
##  [8] dplyr_1.1.3                                        
##  [9] echarts4r_0.4.5                                    
## [10] png_0.1-8                                          
## [11] gridExtra_2.3                                      
## [12] missMethyl_1.36.0                                  
## [13] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [14] beeswarm_0.4.0                                     
## [15] kableExtra_1.3.4                                   
## [16] tictoc_1.2                                         
## [17] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [18] IlluminaHumanMethylation450kmanifest_0.4.0         
## [19] minfi_1.48.0                                       
## [20] bumphunter_1.44.0                                  
## [21] locfit_1.5-9.8                                     
## [22] iterators_1.0.14                                   
## [23] foreach_1.5.2                                      
## [24] Biostrings_2.70.1                                  
## [25] XVector_0.42.0                                     
## [26] SummarizedExperiment_1.32.0                        
## [27] Biobase_2.62.0                                     
## [28] MatrixGenerics_1.14.0                              
## [29] matrixStats_1.1.0                                  
## [30] GenomicRanges_1.54.1                               
## [31] GenomeInfoDb_1.38.1                                
## [32] IRanges_2.36.0                                     
## [33] S4Vectors_0.40.1                                   
## [34] BiocGenerics_0.48.1                                
## [35] eulerr_7.0.0                                       
## [36] limma_3.58.1                                       
## [37] mitch_1.15.0                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.1              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.2            preprocessCore_1.64.0    
##   [7] XML_3.99-0.15             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.7               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.7                httpuv_1.6.12            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] quadprog_1.5-8            rvest_1.0.3              
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.2             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.5                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] illuminaio_0.44.0         webshot_0.5.5            
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.7           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.2           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] SparseArray_1.2.2         xfun_0.41                
##  [55] HDF5Array_1.30.0          withr_2.5.2              
##  [57] fastmap_1.1.1             rhdf5filters_1.14.1      
##  [59] fansi_1.0.5               openssl_2.1.1            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.58.0           
##  [67] RSQLite_2.3.3             tidyr_1.3.0              
##  [69] utf8_1.2.4                generics_0.1.3           
##  [71] data.table_1.14.8         rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.2         S4Arrays_1.2.0           
##  [77] pkgconfig_2.0.3           gtable_0.3.4             
##  [79] blob_1.2.4                siggenes_1.76.0          
##  [81] htmltools_0.5.7           scales_1.2.1             
##  [83] knitr_1.45                rstudioapi_0.15.0        
##  [85] tzdb_0.4.0                rjson_0.2.21             
##  [87] nlme_3.1-163              curl_5.1.0               
##  [89] org.Hs.eg.db_3.18.0       cachem_1.0.8             
##  [91] rhdf5_2.46.0              stringr_1.5.0            
##  [93] KernSmooth_2.23-22        AnnotationDbi_1.64.1     
##  [95] restfulr_0.0.15           GEOquery_2.70.0          
##  [97] pillar_1.9.0              grid_4.3.2               
##  [99] reshape_0.8.9             vctrs_0.6.4              
## [101] promises_1.2.1            dbplyr_2.4.0             
## [103] xtable_1.8-4              evaluate_0.23            
## [105] readr_2.1.4               GenomicFeatures_1.54.1   
## [107] cli_3.6.1                 compiler_4.3.2           
## [109] Rsamtools_2.18.0          rlang_1.1.2              
## [111] crayon_1.5.2              rngtools_1.5.2           
## [113] nor1mix_1.3-0             mclust_6.0.0             
## [115] plyr_1.8.9                stringi_1.7.12           
## [117] viridisLite_0.4.2         BiocParallel_1.36.0      
## [119] munsell_0.5.0             Matrix_1.6-2             
## [121] hms_1.1.3                 sparseMatrixStats_1.14.0 
## [123] bit64_4.0.5               Rhdf5lib_1.24.0          
## [125] KEGGREST_1.42.0           statmod_1.5.0            
## [127] shiny_1.7.5.1             highr_0.10               
## [129] memoise_2.0.1             bslib_0.5.1              
## [131] bit_4.0.5

END of report