Mitch Report

date generated: 2022-05-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             metric
## TNXB      5.726965
## PCDHA1   -8.428865
## NNAT    -12.494999
## PCDHA2   -7.824987
## PCDHA3   -7.259770
## KCNQ1DN -19.538174

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	20094
duplicated_genes_present	0
num_profile_genes_in_sets	9720
num_profile_genes_not_in_sets	10374

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1026
num_genesets_included	1520

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	1.21e-04	-0.702	9.28e-04
Regulation of commissural axon pathfinding by SLIT and ROBO	10	3.91e-04	-0.647	2.57e-03
Apoptotic cleavage of cell adhesion proteins	11	2.10e-04	-0.645	1.50e-03
Transcriptional regulation of testis differentiation	12	2.35e-04	-0.613	1.65e-03
Thyroxine biosynthesis	10	3.42e-03	-0.534	1.59e-02
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	5.58e-03	-0.506	2.29e-02
ERBB2 Activates PTK6 Signaling	13	1.83e-03	-0.499	9.25e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	9.55e-04	-0.493	5.40e-03
Adenylate cyclase activating pathway	10	8.13e-03	-0.483	3.13e-02
Acetylcholine Neurotransmitter Release Cycle	16	9.28e-04	-0.478	5.26e-03
GABA synthesis, release, reuptake and degradation	19	3.44e-04	-0.474	2.29e-03
Platelet sensitization by LDL	17	8.19e-04	0.469	4.77e-03
Defective B3GALTL causes PpS	34	2.91e-06	-0.463	5.21e-05
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	4.92e-04	0.462	3.13e-03
SRP-dependent cotranslational protein targeting to membrane	105	1.16e-15	0.452	3.53e-13
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	9.45e-03	0.452	3.54e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	7.50e-03	-0.446	2.95e-02
O-glycosylation of TSR domain-containing proteins	35	5.09e-06	-0.445	8.03e-05
Carnitine metabolism	11	1.06e-02	-0.445	3.89e-02
Erythrocytes take up carbon dioxide and release oxygen	12	7.92e-03	-0.443	3.06e-02
O2/CO2 exchange in erythrocytes	12	7.92e-03	-0.443	3.06e-02
PD-1 signaling	21	4.47e-04	0.442	2.90e-03
Viral mRNA Translation	84	2.40e-12	0.442	1.66e-10
Resolution of D-loop Structures through Holliday Junction Intermediates	25	1.36e-04	0.441	1.03e-03
Purine ribonucleoside monophosphate biosynthesis	11	1.15e-02	0.440	4.16e-02
PECAM1 interactions	12	8.64e-03	0.438	3.28e-02
Eukaryotic Translation Termination	87	1.87e-12	0.437	1.35e-10
Peptide chain elongation	84	5.53e-12	0.435	3.50e-10
Regulation of FZD by ubiquitination	21	5.62e-04	-0.435	3.50e-03
CASP8 activity is inhibited	11	1.26e-02	0.434	4.46e-02
Dimerization of procaspase-8	11	1.26e-02	0.434	4.46e-02
Regulation by c-FLIP	11	1.26e-02	0.434	4.46e-02
SARS-CoV-2 modulates host translation machinery	45	5.60e-07	0.431	1.29e-05
Nucleotide biosynthesis	14	5.25e-03	0.431	2.18e-02
E2F mediated regulation of DNA replication	14	5.42e-03	0.429	2.23e-02
MASTL Facilitates Mitotic Progression	10	1.92e-02	0.428	6.17e-02
Eukaryotic Translation Elongation	88	4.27e-12	0.427	2.82e-10
Regulation of ornithine decarboxylase (ODC)	49	3.63e-07	0.420	8.77e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	106	8.57e-14	0.419	1.00e-11
Nonsense-Mediated Decay (NMD)	106	8.57e-14	0.419	1.00e-11
Neurotoxicity of clostridium toxins	10	2.19e-02	-0.419	6.87e-02
Adenylate cyclase inhibitory pathway	14	6.97e-03	-0.416	2.78e-02
Processing of Intronless Pre-mRNAs	19	1.69e-03	0.416	8.79e-03
Adherens junctions interactions	26	2.40e-04	-0.416	1.68e-03
Metabolism of polyamines	54	1.23e-07	0.416	3.29e-06
Serotonin Neurotransmitter Release Cycle	16	3.99e-03	-0.416	1.77e-02
GRB2 events in ERBB2 signaling	16	4.06e-03	-0.415	1.80e-02
HDR through MMEJ (alt-NHEJ)	11	1.76e-02	0.413	5.78e-02
Processing of Capped Intronless Pre-mRNA	28	1.58e-04	0.412	1.17e-03
Cyclin A/B1/B2 associated events during G2/M transition	24	4.88e-04	0.411	3.11e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	1.21e-04	-0.702000	9.28e-04
Regulation of commissural axon pathfinding by SLIT and ROBO	10	3.91e-04	-0.647000	2.57e-03
Apoptotic cleavage of cell adhesion proteins	11	2.10e-04	-0.645000	1.50e-03
Transcriptional regulation of testis differentiation	12	2.35e-04	-0.613000	1.65e-03
Thyroxine biosynthesis	10	3.42e-03	-0.534000	1.59e-02
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	5.58e-03	-0.506000	2.29e-02
ERBB2 Activates PTK6 Signaling	13	1.83e-03	-0.499000	9.25e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	9.55e-04	-0.493000	5.40e-03
Adenylate cyclase activating pathway	10	8.13e-03	-0.483000	3.13e-02
Acetylcholine Neurotransmitter Release Cycle	16	9.28e-04	-0.478000	5.26e-03
GABA synthesis, release, reuptake and degradation	19	3.44e-04	-0.474000	2.29e-03
Platelet sensitization by LDL	17	8.19e-04	0.469000	4.77e-03
Defective B3GALTL causes PpS	34	2.91e-06	-0.463000	5.21e-05
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	4.92e-04	0.462000	3.13e-03
SRP-dependent cotranslational protein targeting to membrane	105	1.16e-15	0.452000	3.53e-13
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	9.45e-03	0.452000	3.54e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	7.50e-03	-0.446000	2.95e-02
O-glycosylation of TSR domain-containing proteins	35	5.09e-06	-0.445000	8.03e-05
Carnitine metabolism	11	1.06e-02	-0.445000	3.89e-02
Erythrocytes take up carbon dioxide and release oxygen	12	7.92e-03	-0.443000	3.06e-02
O2/CO2 exchange in erythrocytes	12	7.92e-03	-0.443000	3.06e-02
PD-1 signaling	21	4.47e-04	0.442000	2.90e-03
Viral mRNA Translation	84	2.40e-12	0.442000	1.66e-10
Resolution of D-loop Structures through Holliday Junction Intermediates	25	1.36e-04	0.441000	1.03e-03
Purine ribonucleoside monophosphate biosynthesis	11	1.15e-02	0.440000	4.16e-02
PECAM1 interactions	12	8.64e-03	0.438000	3.28e-02
Eukaryotic Translation Termination	87	1.87e-12	0.437000	1.35e-10
Peptide chain elongation	84	5.53e-12	0.435000	3.50e-10
Regulation of FZD by ubiquitination	21	5.62e-04	-0.435000	3.50e-03
CASP8 activity is inhibited	11	1.26e-02	0.434000	4.46e-02
Dimerization of procaspase-8	11	1.26e-02	0.434000	4.46e-02
Regulation by c-FLIP	11	1.26e-02	0.434000	4.46e-02
SARS-CoV-2 modulates host translation machinery	45	5.60e-07	0.431000	1.29e-05
Nucleotide biosynthesis	14	5.25e-03	0.431000	2.18e-02
E2F mediated regulation of DNA replication	14	5.42e-03	0.429000	2.23e-02
MASTL Facilitates Mitotic Progression	10	1.92e-02	0.428000	6.17e-02
Eukaryotic Translation Elongation	88	4.27e-12	0.427000	2.82e-10
Regulation of ornithine decarboxylase (ODC)	49	3.63e-07	0.420000	8.77e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	106	8.57e-14	0.419000	1.00e-11
Nonsense-Mediated Decay (NMD)	106	8.57e-14	0.419000	1.00e-11
Neurotoxicity of clostridium toxins	10	2.19e-02	-0.419000	6.87e-02
Adenylate cyclase inhibitory pathway	14	6.97e-03	-0.416000	2.78e-02
Processing of Intronless Pre-mRNAs	19	1.69e-03	0.416000	8.79e-03
Adherens junctions interactions	26	2.40e-04	-0.416000	1.68e-03
Metabolism of polyamines	54	1.23e-07	0.416000	3.29e-06
Serotonin Neurotransmitter Release Cycle	16	3.99e-03	-0.416000	1.77e-02
GRB2 events in ERBB2 signaling	16	4.06e-03	-0.415000	1.80e-02
HDR through MMEJ (alt-NHEJ)	11	1.76e-02	0.413000	5.78e-02
Processing of Capped Intronless Pre-mRNA	28	1.58e-04	0.412000	1.17e-03
Cyclin A/B1/B2 associated events during G2/M transition	24	4.88e-04	0.411000	3.11e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	20	1.49e-03	0.410000	7.88e-03
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	20	1.49e-03	0.410000	7.88e-03
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	20	1.49e-03	0.410000	7.88e-03
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	20	1.49e-03	0.410000	7.88e-03
Impaired BRCA2 binding to PALB2	20	1.49e-03	0.410000	7.88e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	2.55e-11	0.409000	1.21e-09
RIP-mediated NFkB activation via ZBP1	16	4.63e-03	0.409000	1.98e-02
Selenocysteine synthesis	87	4.46e-11	0.408000	1.94e-09
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	1.48e-02	-0.406000	5.05e-02
Formation of a pool of free 40S subunits	95	8.68e-12	0.405000	5.07e-10
SLBP independent Processing of Histone Pre-mRNAs	10	2.67e-02	0.404000	7.91e-02
FGFRL1 modulation of FGFR1 signaling	13	1.20e-02	-0.402000	4.31e-02
Autodegradation of the E3 ubiquitin ligase COP1	50	1.01e-06	0.400000	2.08e-05
Response of EIF2AK4 (GCN2) to amino acid deficiency	94	2.27e-11	0.399000	1.11e-09
TICAM1, RIP1-mediated IKK complex recruitment	18	3.46e-03	0.398000	1.60e-02
Voltage gated Potassium channels	42	9.36e-06	-0.395000	1.24e-04
Transport of the SLBP Dependant Mature mRNA	32	1.18e-04	0.393000	9.14e-04
Platelet Adhesion to exposed collagen	13	1.47e-02	-0.391000	5.03e-02
Influenza Viral RNA Transcription and Replication	128	2.26e-14	0.391000	3.81e-12
Resolution of D-Loop Structures	26	6.00e-04	0.389000	3.68e-03
Cap-dependent Translation Initiation	112	1.39e-12	0.387000	1.05e-10
Eukaryotic Translation Initiation	112	1.39e-12	0.387000	1.05e-10
Negative regulation of NOTCH4 signaling	52	1.37e-06	0.387000	2.71e-05
Stabilization of p53	55	7.35e-07	0.386000	1.60e-05
SHC1 events in ERBB4 signaling	14	1.25e-02	-0.385000	4.45e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	105	8.67e-12	0.385000	5.07e-10
Class I peroxisomal membrane protein import	18	4.80e-03	0.384000	2.03e-02
L13a-mediated translational silencing of Ceruloplasmin expression	104	2.20e-11	0.380000	1.11e-09
Translocation of ZAP-70 to Immunological synapse	17	6.75e-03	0.379000	2.71e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	1.40e-02	-0.379000	4.84e-02
Diseases of hemostasis	14	1.40e-02	-0.379000	4.84e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	2.95e-02	0.379000	8.53e-02
Ubiquitin-dependent degradation of Cyclin D	50	3.96e-06	0.377000	6.71e-05
Endosomal/Vacuolar pathway	10	3.91e-02	0.377000	1.08e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	1.88e-02	-0.376000	6.06e-02
mRNA Capping	28	5.74e-04	0.376000	3.54e-03
Transport of the SLBP independent Mature mRNA	31	2.91e-04	0.376000	2.00e-03
Influenza Infection	147	4.35e-15	0.375000	1.10e-12
Phosphorylation of CD3 and TCR zeta chains	20	3.73e-03	0.375000	1.69e-02
Transcriptional regulation of pluripotent stem cells	29	4.81e-04	-0.374000	3.08e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	7.55e-06	0.373000	1.07e-04
Interleukin-6 signaling	11	3.21e-02	0.373000	9.14e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	7.85e-03	0.372000	3.06e-02
Impaired BRCA2 binding to RAD51	31	3.36e-04	0.372000	2.26e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	35	1.50e-04	0.370000	1.12e-03
Diseases of DNA Double-Strand Break Repair	35	1.50e-04	0.370000	1.12e-03
ALK mutants bind TKIs	12	2.64e-02	0.370000	7.87e-02
GRB2 events in EGFR signaling	12	2.65e-02	-0.370000	7.87e-02
Phase 4 - resting membrane potential	19	5.29e-03	-0.370000	2.19e-02
Vpu mediated degradation of CD4	50	6.31e-06	0.369000	9.40e-05
ZBP1(DAI) mediated induction of type I IFNs	20	4.42e-03	0.368000	1.92e-02
Formation of the ternary complex, and subsequently, the 43S complex	47	1.33e-05	0.367000	1.64e-04
mRNA decay by 3’ to 5’ exoribonuclease	15	1.41e-02	0.366000	4.86e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	39	7.85e-05	0.365000	6.49e-04
NEP/NS2 Interacts with the Cellular Export Machinery	29	6.68e-04	0.365000	4.01e-03
Presynaptic phase of homologous DNA pairing and strand exchange	34	2.30e-04	0.365000	1.63e-03
Export of Viral Ribonucleoproteins from Nucleus	30	5.73e-04	0.363000	3.54e-03
Maturation of nucleoprotein	11	3.73e-02	0.363000	1.04e-01
Calcitonin-like ligand receptors	10	4.77e-02	-0.362000	1.27e-01
FGFR1 ligand binding and activation	15	1.56e-02	-0.360000	5.27e-02
Nuclear Pore Complex (NPC) Disassembly	33	3.40e-04	0.360000	2.28e-03
PI3K events in ERBB4 signaling	10	4.88e-02	-0.360000	1.29e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.14e-05	0.359000	1.44e-04
p53-Independent DNA Damage Response	50	1.14e-05	0.359000	1.44e-04
p53-Independent G1/S DNA damage checkpoint	50	1.14e-05	0.359000	1.44e-04
Crosslinking of collagen fibrils	10	4.97e-02	-0.358000	1.29e-01
Translation	262	2.35e-23	0.357000	1.79e-20
SHC1 events in EGFR signaling	13	2.58e-02	-0.357000	7.77e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	58	2.76e-06	0.356000	5.04e-05
Complex I biogenesis	44	4.42e-05	0.356000	4.00e-04
Synthesis of IP2, IP, and Ins in the cytosol	13	2.65e-02	-0.355000	7.87e-02
Cleavage of the damaged purine	11	4.14e-02	0.355000	1.13e-01
Depurination	11	4.14e-02	0.355000	1.13e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	4.14e-02	0.355000	1.13e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	7.88e-06	0.355000	1.11e-04
Homologous DNA Pairing and Strand Exchange	37	1.94e-04	0.354000	1.40e-03
LGI-ADAM interactions	14	2.19e-02	-0.354000	6.87e-02
RNA Pol II CTD phosphorylation and interaction with CE	26	1.81e-03	0.353000	9.20e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	1.81e-03	0.353000	9.20e-03
Metallothioneins bind metals	11	4.35e-02	-0.351000	1.18e-01
Amine ligand-binding receptors	41	9.93e-05	-0.351000	7.91e-04
Transport of Mature mRNA Derived from an Intronless Transcript	38	1.84e-04	0.351000	1.34e-03
NS1 Mediated Effects on Host Pathways	38	1.87e-04	0.350000	1.35e-03
Deadenylation of mRNA	24	3.01e-03	0.350000	1.41e-02
Dopamine Neurotransmitter Release Cycle	20	6.76e-03	-0.350000	2.71e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	1.89e-05	0.350000	2.12e-04
GABA receptor activation	57	4.97e-06	-0.350000	8.03e-05
Activation of NF-kappaB in B cells	64	1.32e-06	0.349000	2.64e-05
Activation of SMO	17	1.27e-02	-0.349000	4.48e-02
Activation of the TFAP2 (AP-2) family of transcription factors	11	4.51e-02	-0.349000	1.21e-01
Nuclear events stimulated by ALK signaling in cancer	18	1.05e-02	0.348000	3.85e-02
KSRP (KHSRP) binds and destabilizes mRNA	17	1.33e-02	0.347000	4.64e-02
SARS-CoV-2 modulates autophagy	11	4.64e-02	0.347000	1.24e-01
Initiation of Nuclear Envelope (NE) Reformation	18	1.09e-02	0.347000	3.96e-02
Polo-like kinase mediated events	16	1.64e-02	0.346000	5.48e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	22	4.92e-03	0.346000	2.06e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.31e-05	0.346000	1.63e-04
Selenoamino acid metabolism	103	1.31e-09	0.346000	4.14e-08
Vif-mediated degradation of APOBEC3G	50	2.36e-05	0.345000	2.46e-04
Phase 2 - plateau phase	14	2.55e-02	-0.345000	7.72e-02
Interactions of Vpr with host cellular proteins	32	7.50e-04	0.344000	4.42e-03
Serotonin receptors	11	4.82e-02	-0.344000	1.28e-01
SUMOylation of SUMOylation proteins	32	7.64e-04	0.344000	4.48e-03
Response to metal ions	14	2.60e-02	-0.344000	7.77e-02
GLI3 is processed to GLI3R by the proteasome	58	5.96e-06	0.344000	9.06e-05
Defective CFTR causes cystic fibrosis	59	6.16e-06	0.340000	9.28e-05
Vpr-mediated nuclear import of PICs	31	1.07e-03	0.339000	5.95e-03
SCF-beta-TrCP mediated degradation of Emi1	53	1.91e-05	0.339000	2.12e-04
Neurotransmitter release cycle	47	5.75e-05	-0.339000	4.96e-04
Nuclear import of Rev protein	31	1.09e-03	0.339000	6.02e-03
Metabolism of non-coding RNA	48	4.89e-05	0.339000	4.32e-04
snRNP Assembly	48	4.89e-05	0.339000	4.32e-04
Ribosomal scanning and start codon recognition	54	1.73e-05	0.338000	2.02e-04
Degradation of GLI2 by the proteasome	58	9.29e-06	0.336000	1.24e-04
RNA Polymerase II Transcription Termination	50	3.89e-05	0.336000	3.58e-04
Nitric oxide stimulates guanylate cyclase	22	6.35e-03	-0.336000	2.57e-02
ERBB2 Regulates Cell Motility	15	2.47e-02	-0.335000	7.55e-02
Interactions of Rev with host cellular proteins	34	7.30e-04	0.335000	4.33e-03
rRNA processing in the nucleus and cytosol	176	1.90e-14	0.334000	3.61e-12
PKA activation in glucagon signalling	17	1.70e-02	-0.334000	5.65e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.71e-02	0.334000	5.65e-02
Citric acid cycle (TCA cycle)	21	8.03e-03	0.334000	3.10e-02
Major pathway of rRNA processing in the nucleolus and cytosol	169	7.49e-14	0.333000	1.00e-11
Signaling by Hippo	17	1.75e-02	-0.333000	5.77e-02
tRNA processing in the nucleus	53	2.78e-05	0.333000	2.72e-04
Regulation of Apoptosis	51	4.06e-05	0.332000	3.70e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	2.05e-05	0.332000	2.23e-04
Hh mutants are degraded by ERAD	54	2.48e-05	0.332000	2.53e-04
Translation initiation complex formation	54	2.55e-05	0.331000	2.56e-04
Regulation of expression of SLITs and ROBOs	158	7.11e-13	0.331000	6.75e-11
Receptor-type tyrosine-protein phosphatases	16	2.20e-02	-0.331000	6.90e-02
Cross-presentation of soluble exogenous antigens (endosomes)	48	7.51e-05	0.330000	6.24e-04
NIK–>noncanonical NF-kB signaling	57	1.61e-05	0.330000	1.93e-04
Methylation	14	3.29e-02	0.329000	9.32e-02
Mitochondrial tRNA aminoacylation	18	1.56e-02	0.329000	5.27e-02
Transcriptional regulation by small RNAs	43	2.23e-04	0.325000	1.59e-03
Formation of RNA Pol II elongation complex	49	8.38e-05	0.325000	6.81e-04
RNA Polymerase II Transcription Elongation	49	8.38e-05	0.325000	6.81e-04
Interferon alpha/beta signaling	63	8.25e-06	0.325000	1.14e-04
HCMV Early Events	54	3.72e-05	0.324000	3.47e-04
Nuclear signaling by ERBB4	30	2.16e-03	-0.323000	1.06e-02
Degradation of GLI1 by the proteasome	58	2.17e-05	0.322000	2.30e-04
Diseases of DNA repair	45	1.85e-04	0.322000	1.35e-03
rRNA processing	180	9.33e-14	0.322000	1.01e-11
Diseases associated with N-glycosylation of proteins	19	1.53e-02	0.321000	5.21e-02
mRNA 3’-end processing	41	3.74e-04	0.321000	2.48e-03
Signaling by Retinoic Acid	40	4.46e-04	-0.321000	2.90e-03
HDMs demethylate histones	17	2.22e-02	0.320000	6.92e-02
Degradation of AXIN	53	5.50e-05	0.320000	4.78e-04
Autodegradation of Cdh1 by Cdh1:APC/C	60	1.81e-05	0.320000	2.08e-04
Rev-mediated nuclear export of HIV RNA	32	1.74e-03	0.320000	9.00e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	61	1.58e-05	0.320000	1.90e-04
Respiratory electron transport	81	6.71e-07	0.319000	1.48e-05
Inhibition of DNA recombination at telomere	20	1.36e-02	0.319000	4.76e-02
TRAF6 mediated NF-kB activation	24	7.00e-03	0.318000	2.79e-02
Downstream TCR signaling	91	1.87e-07	0.316000	4.81e-06
RIPK1-mediated regulated necrosis	27	4.54e-03	0.315000	1.94e-02
Regulation of necroptotic cell death	27	4.54e-03	0.315000	1.94e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	86	4.41e-07	0.315000	1.03e-05
APC truncation mutants have impaired AXIN binding	13	4.96e-02	0.314000	1.29e-01
AXIN missense mutants destabilize the destruction complex	13	4.96e-02	0.314000	1.29e-01
Signaling by AMER1 mutants	13	4.96e-02	0.314000	1.29e-01
Signaling by APC mutants	13	4.96e-02	0.314000	1.29e-01
Signaling by AXIN mutants	13	4.96e-02	0.314000	1.29e-01
Truncations of AMER1 destabilize the destruction complex	13	4.96e-02	0.314000	1.29e-01
Early Phase of HIV Life Cycle	14	4.19e-02	0.314000	1.14e-01
Neurexins and neuroligins	52	9.07e-05	-0.314000	7.33e-04
Formation of HIV elongation complex in the absence of HIV Tat	36	1.14e-03	0.313000	6.23e-03
APC/C:Cdc20 mediated degradation of Securin	64	1.48e-05	0.313000	1.80e-04
G2/M Checkpoints	119	3.92e-09	0.312000	1.22e-07
Ras activation upon Ca2+ influx through NMDA receptor	19	1.85e-02	-0.312000	6.00e-02
Regulation of IFNA/IFNB signaling	16	3.07e-02	0.312000	8.78e-02
Degradation of DVL	55	6.40e-05	0.312000	5.38e-04
FCERI mediated NF-kB activation	72	5.05e-06	0.311000	8.03e-05
p53-Dependent G1 DNA Damage Response	64	1.69e-05	0.311000	2.00e-04
p53-Dependent G1/S DNA damage checkpoint	64	1.69e-05	0.311000	2.00e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	72	5.12e-06	0.311000	8.03e-05
SHC1 events in ERBB2 signaling	22	1.22e-02	-0.309000	4.37e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	4.07e-03	0.308000	1.80e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	4.07e-03	0.308000	1.80e-02
Orc1 removal from chromatin	63	2.41e-05	0.308000	2.48e-04
Regulation of RUNX3 expression and activity	53	1.11e-04	0.307000	8.62e-04
Downstream signaling events of B Cell Receptor (BCR)	78	2.95e-06	0.306000	5.21e-05
Negative regulators of DDX58/IFIH1 signaling	34	2.05e-03	0.305000	1.01e-02
Transport of Ribonucleoproteins into the Host Nucleus	29	4.46e-03	0.305000	1.92e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	73	6.57e-06	0.305000	9.69e-05
mRNA Splicing - Major Pathway	155	5.54e-11	0.305000	2.27e-09
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	70	1.04e-05	0.305000	1.36e-04
HS-GAG biosynthesis	28	5.31e-03	-0.304000	2.20e-02
Antiviral mechanism by IFN-stimulated genes	77	4.09e-06	0.304000	6.75e-05
Transport of Mature Transcript to Cytoplasm	63	3.08e-05	0.304000	2.98e-04
Nucleotide-like (purinergic) receptors	13	5.81e-02	-0.303000	1.44e-01
HDL remodeling	10	9.67e-02	-0.303000	2.10e-01
SHC-mediated cascade:FGFR1	21	1.61e-02	-0.303000	5.40e-02
NoRC negatively regulates rRNA expression	43	5.84e-04	0.303000	3.59e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	70	1.18e-05	0.303000	1.49e-04
Polymerase switching on the C-strand of the telomere	22	1.41e-02	0.302000	4.86e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	54	1.22e-04	0.302000	9.32e-04
Long-term potentiation	22	1.42e-02	-0.302000	4.88e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	69	1.46e-05	0.302000	1.79e-04
Formation of HIV-1 elongation complex containing HIV-1 Tat	34	2.32e-03	0.302000	1.12e-02
HIV Transcription Elongation	34	2.32e-03	0.302000	1.12e-02
Tat-mediated elongation of the HIV-1 transcript	34	2.32e-03	0.302000	1.12e-02
Eicosanoid ligand-binding receptors	13	6.02e-02	-0.301000	1.48e-01
mRNA Splicing	165	3.16e-11	0.299000	1.41e-09
Metabolism of RNA	600	5.48e-36	0.299000	8.33e-33
G1/S DNA Damage Checkpoints	66	2.64e-05	0.299000	2.61e-04
ABC transporters in lipid homeostasis	17	3.35e-02	0.298000	9.46e-02
Meiotic recombination	26	8.59e-03	0.298000	3.28e-02
Mitochondrial translation	92	8.00e-07	0.298000	1.69e-05
Degradation of cysteine and homocysteine	14	5.39e-02	-0.297000	1.37e-01
Defective pyroptosis	11	8.80e-02	0.297000	2.00e-01
FGFR1c ligand binding and activation	11	8.84e-02	-0.297000	2.00e-01
Signaling by activated point mutants of FGFR1	11	8.84e-02	-0.297000	2.00e-01
Viral Messenger RNA Synthesis	41	1.01e-03	0.297000	5.66e-03
RA biosynthesis pathway	21	1.86e-02	-0.297000	6.03e-02
Processing of Capped Intron-Containing Pre-mRNA	209	1.47e-13	0.296000	1.49e-11
Unblocking of NMDA receptors, glutamate binding and activation	19	2.58e-02	-0.295000	7.77e-02
SUMOylation of ubiquitinylation proteins	36	2.20e-03	0.295000	1.08e-02
SCF(Skp2)-mediated degradation of p27/p21	58	1.07e-04	0.294000	8.43e-04
TNFR1-induced NFkappaB signaling pathway	20	2.29e-02	0.294000	7.07e-02
Mitochondrial translation termination	86	2.58e-06	0.293000	4.78e-05
ISG15 antiviral mechanism	70	2.24e-05	0.293000	2.36e-04
tRNA Aminoacylation	24	1.31e-02	0.293000	4.59e-02
tRNA processing	90	1.62e-06	0.292000	3.11e-05
HDR through Homologous Recombination (HRR)	58	1.18e-04	0.292000	9.14e-04
Defective B4GALT7 causes EDS, progeroid type	17	3.76e-02	-0.291000	1.05e-01
Gap junction degradation	10	1.12e-01	0.290000	2.34e-01
TCR signaling	111	1.34e-07	0.290000	3.50e-06
Response of EIF2AK1 (HRI) to heme deficiency	14	6.09e-02	0.289000	1.48e-01
TP53 Regulates Transcription of DNA Repair Genes	52	3.15e-04	0.289000	2.15e-03
Regulation of mRNA stability by proteins that bind AU-rich elements	87	3.23e-06	0.289000	5.64e-05
RNA polymerase II transcribes snRNA genes	71	2.61e-05	0.289000	2.60e-04
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	9.46e-03	0.288000	3.54e-02
PI3K events in ERBB2 signaling	16	4.63e-02	-0.288000	1.24e-01
Mitochondrial translation initiation	86	3.97e-06	0.288000	6.71e-05
Transcription of the HIV genome	58	1.55e-04	0.287000	1.15e-03
Chondroitin sulfate biosynthesis	18	3.54e-02	-0.286000	9.95e-02
G2/M Transition	165	2.21e-10	0.286000	8.61e-09
RNA Polymerase II Pre-transcription Events	69	4.05e-05	0.286000	3.70e-04
Glutamate Neurotransmitter Release Cycle	23	1.78e-02	-0.285000	5.82e-02
Norepinephrine Neurotransmitter Release Cycle	16	4.81e-02	-0.285000	1.28e-01
rRNA modification in the nucleus and cytosol	51	4.40e-04	0.284000	2.89e-03
HDR through Single Strand Annealing (SSA)	34	4.12e-03	0.284000	1.81e-02
Assembly of the pre-replicative complex	74	2.41e-05	0.284000	2.48e-04
CDK-mediated phosphorylation and removal of Cdc6	69	4.61e-05	0.284000	4.12e-04
Mitotic G2-G2/M phases	167	2.54e-10	0.284000	9.63e-09
Deadenylation-dependent mRNA decay	54	3.17e-04	0.283000	2.15e-03
Potassium Channels	102	8.01e-07	-0.283000	1.69e-05
Formation of the Early Elongation Complex	28	1.01e-02	0.281000	3.74e-02
Formation of the HIV-1 Early Elongation Complex	28	1.01e-02	0.281000	3.74e-02
Host Interactions of HIV factors	121	9.57e-08	0.281000	2.60e-06
Regulation of gene expression in beta cells	21	2.61e-02	-0.280000	7.81e-02
Protein methylation	11	1.07e-01	0.280000	2.26e-01
APC/C-mediated degradation of cell cycle proteins	84	9.01e-06	0.280000	1.21e-04
Regulation of mitotic cell cycle	84	9.01e-06	0.280000	1.21e-04
Golgi Cisternae Pericentriolar Stack Reorganization	14	7.03e-02	0.279000	1.67e-01
Phospholipase C-mediated cascade: FGFR1	16	5.31e-02	-0.279000	1.36e-01
Recycling of bile acids and salts	16	5.34e-02	-0.279000	1.37e-01
Hh mutants abrogate ligand secretion	57	2.76e-04	0.278000	1.91e-03
Cellular response to starvation	138	1.64e-08	0.278000	4.79e-07
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	3.39e-03	0.278000	1.59e-02
Beta defensins	28	1.08e-02	0.278000	3.95e-02
Mitochondrial translation elongation	86	8.23e-06	0.278000	1.14e-04
Cellular response to hypoxia	70	5.83e-05	0.278000	5.00e-04
Dectin-1 mediated noncanonical NF-kB signaling	60	1.98e-04	0.278000	1.42e-03
Class B/2 (Secretin family receptors)	90	5.36e-06	-0.277000	8.31e-05
Interleukin-2 signaling	10	1.29e-01	0.277000	2.59e-01
Signaling by NOTCH4	79	2.06e-05	0.277000	2.23e-04
Cytosolic sulfonation of small molecules	22	2.47e-02	-0.277000	7.55e-02
ABC transporter disorders	75	3.51e-05	0.276000	3.32e-04
Transcriptional regulation of granulopoiesis	30	8.83e-03	-0.276000	3.35e-02
Formation of Fibrin Clot (Clotting Cascade)	37	3.68e-03	-0.276000	1.68e-02
Metabolism of Angiotensinogen to Angiotensins	15	6.44e-02	-0.276000	1.55e-01
Activation of GABAB receptors	43	1.79e-03	-0.275000	9.16e-03
GABA B receptor activation	43	1.79e-03	-0.275000	9.16e-03
Regulation of APC/C activators between G1/S and early anaphase	77	2.97e-05	0.275000	2.89e-04
HATs acetylate histones	59	2.61e-04	0.275000	1.81e-03
RNA Polymerase III Transcription Initiation	36	4.35e-03	0.275000	1.91e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.19e-02	0.275000	4.28e-02
Assembly and cell surface presentation of NMDA receptors	23	2.28e-02	-0.274000	7.05e-02
CS/DS degradation	12	1.00e-01	-0.274000	2.17e-01
Signaling by ALK	26	1.56e-02	0.274000	5.27e-02
Signaling by ALK fusions and activated point mutants	51	7.25e-04	0.274000	4.32e-03
Signaling by ALK in cancer	51	7.25e-04	0.274000	4.32e-03
Activation of the AP-1 family of transcription factors	10	1.35e-01	0.273000	2.67e-01
Negative epigenetic regulation of rRNA expression	45	1.57e-03	0.272000	8.25e-03
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	5.94e-02	0.272000	1.46e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	3.51e-02	-0.272000	9.87e-02
O-linked glycosylation	96	4.05e-06	-0.272000	6.75e-05
DNA Replication Pre-Initiation	88	1.02e-05	0.272000	1.34e-04
Negative regulation of FLT3	15	6.81e-02	0.272000	1.63e-01
MyD88 deficiency (TLR2/4)	16	6.01e-02	-0.271000	1.48e-01
Protein-protein interactions at synapses	78	3.41e-05	-0.271000	3.24e-04
Heparan sulfate/heparin (HS-GAG) metabolism	49	1.02e-03	-0.271000	5.66e-03
G1/S Transition	119	3.19e-07	0.271000	7.83e-06
Switching of origins to a post-replicative state	82	2.25e-05	0.271000	2.36e-04
UCH proteinases	81	2.57e-05	0.270000	2.57e-04
Elevation of cytosolic Ca2+ levels	16	6.17e-02	-0.270000	1.50e-01
ERKs are inactivated	13	9.23e-02	0.270000	2.05e-01
Neuronal System	371	4.83e-19	-0.269000	2.45e-16
Miscellaneous substrates	12	1.07e-01	-0.269000	2.25e-01
Leading Strand Synthesis	13	9.33e-02	0.269000	2.06e-01
Polymerase switching	13	9.33e-02	0.269000	2.06e-01
Folding of actin by CCT/TriC	10	1.42e-01	0.268000	2.79e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	35	6.10e-03	0.268000	2.48e-02
Tandem pore domain potassium channels	12	1.09e-01	-0.267000	2.28e-01
Interleukin-35 Signalling	12	1.10e-01	0.267000	2.29e-01
Condensation of Prometaphase Chromosomes	11	1.27e-01	0.266000	2.57e-01
Metabolism of amine-derived hormones	17	5.77e-02	-0.266000	1.44e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.30e-01	0.263000	2.61e-01
Nuclear events mediated by NFE2L2	76	7.99e-05	0.262000	6.56e-04
CD28 dependent Vav1 pathway	11	1.34e-01	0.261000	2.66e-01
Physiological factors	12	1.18e-01	-0.261000	2.42e-01
Vitamin B5 (pantothenate) metabolism	16	7.10e-02	0.261000	1.68e-01
Presynaptic depolarization and calcium channel opening	12	1.18e-01	-0.260000	2.42e-01
Peptide hormone biosynthesis	11	1.35e-01	-0.260000	2.67e-01
Paracetamol ADME	29	1.52e-02	-0.260000	5.16e-02
Signaling by ERBB4	55	8.32e-04	-0.260000	4.83e-03
Metabolism of cofactors	19	4.97e-02	0.260000	1.29e-01
HCMV Infection	75	9.91e-05	0.260000	7.91e-04
mRNA Splicing - Minor Pathway	48	1.86e-03	0.260000	9.35e-03
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.75e-02	0.259000	5.77e-02
Activation of ATR in response to replication stress	30	1.39e-02	0.259000	4.84e-02
NCAM1 interactions	35	7.92e-03	-0.259000	3.06e-02
FGFR2 alternative splicing	25	2.53e-02	0.258000	7.68e-02
Reversible hydration of carbon dioxide	11	1.38e-01	-0.258000	2.72e-01
TNFR2 non-canonical NF-kB pathway	93	1.75e-05	0.258000	2.03e-04
Degradation of beta-catenin by the destruction complex	81	6.18e-05	0.257000	5.22e-04
Mitochondrial iron-sulfur cluster biogenesis	12	1.23e-01	0.257000	2.51e-01
Cell-cell junction organization	56	8.90e-04	-0.257000	5.07e-03
Creation of C4 and C2 activators	14	9.65e-02	0.256000	2.10e-01
Acetylcholine regulates insulin secretion	10	1.62e-01	-0.255000	3.03e-01
ER-Phagosome pathway	87	3.84e-05	0.255000	3.56e-04
Cyclin A:Cdk2-associated events at S phase entry	83	5.86e-05	0.255000	5.00e-04
FGFR3 mutant receptor activation	11	1.43e-01	-0.255000	2.80e-01
Signaling by activated point mutants of FGFR3	11	1.43e-01	-0.255000	2.80e-01
Mitochondrial protein import	48	2.25e-03	0.255000	1.10e-02
Diseases associated with O-glycosylation of proteins	60	6.49e-04	-0.254000	3.93e-03
HIV Transcription Initiation	43	3.92e-03	0.254000	1.75e-02
RNA Polymerase II HIV Promoter Escape	43	3.92e-03	0.254000	1.75e-02
RNA Polymerase II Promoter Escape	43	3.92e-03	0.254000	1.75e-02
RNA Polymerase II Transcription Initiation	43	3.92e-03	0.254000	1.75e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	3.92e-03	0.254000	1.75e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	3.92e-03	0.254000	1.75e-02
Digestion	20	4.91e-02	0.254000	1.29e-01
HIV Infection	208	2.79e-10	0.254000	1.03e-08
G2/M DNA damage checkpoint	55	1.13e-03	0.254000	6.23e-03
FGFR3 ligand binding and activation	12	1.28e-01	-0.254000	2.59e-01
FGFR3c ligand binding and activation	12	1.28e-01	-0.254000	2.59e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.65e-01	0.254000	3.06e-01
Myogenesis	29	1.84e-02	-0.253000	6.00e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	2.88e-02	-0.252000	8.40e-02
Separation of Sister Chromatids	156	5.29e-08	0.252000	1.49e-06
Cell-extracellular matrix interactions	14	1.02e-01	-0.252000	2.20e-01
HIV Life Cycle	131	6.55e-07	0.252000	1.46e-05
FGFR4 ligand binding and activation	13	1.16e-01	-0.252000	2.39e-01
CTNNB1 S33 mutants aren’t phosphorylated	14	1.03e-01	0.251000	2.20e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	1.03e-01	0.251000	2.20e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	1.03e-01	0.251000	2.20e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	1.03e-01	0.251000	2.20e-01
Signaling by CTNNB1 phospho-site mutants	14	1.03e-01	0.251000	2.20e-01
Signaling by GSK3beta mutants	14	1.03e-01	0.251000	2.20e-01
Transmission across Chemical Synapses	237	2.94e-11	-0.251000	1.35e-09
Regulation of TP53 Activity through Association with Co-factors	14	1.05e-01	-0.250000	2.22e-01
Regulation of beta-cell development	41	5.65e-03	-0.250000	2.31e-02
Mitotic Metaphase and Anaphase	212	3.67e-10	0.250000	1.27e-08
Platelet calcium homeostasis	27	2.49e-02	-0.249000	7.59e-02
MAPK6/MAPK4 signaling	85	7.18e-05	0.249000	6.00e-04
Association of TriC/CCT with target proteins during biosynthesis	38	7.92e-03	0.249000	3.06e-02
Interleukin-12 signaling	43	4.85e-03	0.248000	2.04e-02
HDACs deacetylate histones	29	2.08e-02	0.248000	6.63e-02
Mitotic Anaphase	211	5.69e-10	0.248000	1.92e-08
Late Phase of HIV Life Cycle	118	3.47e-06	0.247000	5.99e-05
The citric acid (TCA) cycle and respiratory electron transport	132	9.51e-07	0.247000	1.98e-05
Telomere C-strand (Lagging Strand) Synthesis	30	1.92e-02	0.247000	6.17e-02
SARS-CoV-2-host interactions	171	2.72e-08	0.246000	7.80e-07
CTLA4 inhibitory signaling	21	5.10e-02	0.246000	1.32e-01
RNA Polymerase I Transcription Termination	27	2.70e-02	0.246000	7.96e-02
Activated point mutants of FGFR2	16	8.91e-02	-0.245000	2.01e-01
Cyclin E associated events during G1/S transition	81	1.35e-04	0.245000	1.03e-03
Formation of TC-NER Pre-Incision Complex	50	2.75e-03	0.245000	1.31e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta	68	5.01e-04	0.244000	3.17e-03
Caspase activation via Death Receptors in the presence of ligand	16	9.17e-02	0.243000	2.05e-01
HCMV Late Events	50	2.89e-03	0.243000	1.37e-02
AKT phosphorylates targets in the cytosol	14	1.15e-01	0.243000	2.37e-01
Regulation of TNFR1 signaling	31	1.95e-02	0.242000	6.23e-02
PINK1-PRKN Mediated Mitophagy	20	6.05e-02	0.242000	1.48e-01
Diseases associated with visual transduction	11	1.65e-01	-0.242000	3.06e-01
Diseases of the neuronal system	11	1.65e-01	-0.242000	3.06e-01
Retinoid cycle disease events	11	1.65e-01	-0.242000	3.06e-01
Activation of NMDA receptors and postsynaptic events	69	5.27e-04	-0.241000	3.32e-03
SUMOylation of DNA replication proteins	43	6.28e-03	0.241000	2.55e-02
Cytosolic sensors of pathogen-associated DNA	60	1.25e-03	0.241000	6.83e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	1.07e-01	-0.240000	2.25e-01
Signaling by the B Cell Receptor (BCR)	105	2.08e-05	0.240000	2.24e-04
DNA Damage/Telomere Stress Induced Senescence	28	2.78e-02	0.240000	8.14e-02
Interleukin-2 family signaling	39	9.57e-03	0.240000	3.57e-02
Hedgehog ligand biogenesis	63	1.01e-03	0.240000	5.65e-03
RNA Polymerase I Promoter Escape	28	2.83e-02	0.239000	8.25e-02
Cell Cycle Checkpoints	233	3.18e-10	0.239000	1.12e-08
Nuclear Envelope (NE) Reassembly	68	6.54e-04	0.239000	3.95e-03
Removal of the Flap Intermediate from the C-strand	17	8.93e-02	0.238000	2.01e-01
Attenuation phase	25	3.98e-02	0.237000	1.10e-01
IRF3-mediated induction of type I IFN	11	1.73e-01	0.237000	3.15e-01
PKA activation	18	8.15e-02	-0.237000	1.89e-01
BBSome-mediated cargo-targeting to cilium	22	5.43e-02	0.237000	1.38e-01
Signaling by ERBB2 TMD/JMD mutants	21	6.05e-02	-0.237000	1.48e-01
TICAM1-dependent activation of IRF3/IRF7	12	1.56e-01	0.237000	2.94e-01
MAPK targets/ Nuclear events mediated by MAP kinases	29	2.78e-02	0.236000	8.14e-02
Initial triggering of complement	21	6.29e-02	0.234000	1.52e-01
RAF-independent MAPK1/3 activation	22	5.72e-02	0.234000	1.43e-01
AURKA Activation by TPX2	62	1.45e-03	0.234000	7.83e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	30	2.67e-02	0.234000	7.90e-02
Fc epsilon receptor (FCERI) signaling	124	6.98e-06	0.234000	1.00e-04
Mitotic G1 phase and G1/S transition	137	2.45e-06	0.233000	4.64e-05
Interleukin-15 signaling	13	1.46e-01	0.233000	2.83e-01
TNFR1-induced proapoptotic signaling	13	1.46e-01	0.233000	2.83e-01
Regulation of PLK1 Activity at G2/M Transition	75	5.48e-04	0.231000	3.44e-03
S Phase	148	1.29e-06	0.230000	2.62e-05
Receptor Mediated Mitophagy	10	2.07e-01	-0.230000	3.59e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	61	1.88e-03	0.230000	9.40e-03
Common Pathway of Fibrin Clot Formation	21	6.83e-02	-0.230000	1.64e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.69e-01	-0.229000	3.09e-01
alpha-linolenic acid (ALA) metabolism	12	1.69e-01	-0.229000	3.09e-01
Intraflagellar transport	32	2.47e-02	0.229000	7.55e-02
Synthesis of DNA	109	3.57e-05	0.229000	3.35e-04
Lysine catabolism	10	2.10e-01	-0.229000	3.64e-01
DNA Replication	116	2.11e-05	0.229000	2.26e-04
Inwardly rectifying K+ channels	35	1.93e-02	-0.229000	6.18e-02
Regulation of PTEN stability and activity	66	1.33e-03	0.228000	7.19e-03
Prefoldin mediated transfer of substrate to CCT/TriC	25	4.84e-02	0.228000	1.28e-01
ABC-family proteins mediated transport	98	9.60e-05	0.228000	7.72e-04
HuR (ELAVL1) binds and stabilizes mRNA	10	2.12e-01	-0.228000	3.66e-01
Tie2 Signaling	18	9.44e-02	-0.228000	2.08e-01
Protein localization	137	4.39e-06	0.227000	7.17e-05
Sodium/Calcium exchangers	10	2.14e-01	-0.227000	3.67e-01
Mitochondrial calcium ion transport	16	1.16e-01	0.227000	2.39e-01
TP53 Regulates Transcription of Cell Cycle Genes	47	7.22e-03	0.226000	2.86e-02
SARS-CoV-2 Infection	249	8.02e-10	0.226000	2.65e-08
Glutathione synthesis and recycling	13	1.58e-01	0.226000	2.98e-01
Interleukin-12 family signaling	53	4.70e-03	0.224000	2.00e-02
DNA Damage Recognition in GG-NER	36	1.98e-02	0.224000	6.32e-02
Nuclear Envelope Breakdown	47	7.87e-03	0.224000	3.06e-02
A tetrasaccharide linker sequence is required for GAG synthesis	23	6.29e-02	-0.224000	1.52e-01
Costimulation by the CD28 family	65	1.83e-03	0.223000	9.25e-03
PKA-mediated phosphorylation of CREB	19	9.20e-02	-0.223000	2.05e-01
Ub-specific processing proteases	150	2.47e-06	0.223000	4.64e-05
HIV elongation arrest and recovery	25	5.38e-02	0.223000	1.37e-01
Pausing and recovery of HIV elongation	25	5.38e-02	0.223000	1.37e-01
Signaling by FGFR2 IIIa TM	19	9.27e-02	0.223000	2.06e-01
SHC-mediated cascade:FGFR4	19	9.27e-02	-0.223000	2.06e-01
SHC-mediated cascade:FGFR2	22	7.11e-02	-0.222000	1.68e-01
Neurotransmitter receptors and postsynaptic signal transmission	175	4.18e-07	-0.222000	9.92e-06
Post NMDA receptor activation events	58	3.49e-03	-0.222000	1.61e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	1.84e-01	-0.222000	3.31e-01
Defective EXT2 causes exostoses 2	12	1.84e-01	-0.222000	3.31e-01
SHC-mediated cascade:FGFR3	17	1.14e-01	-0.222000	2.35e-01
M Phase	316	1.40e-11	0.221000	7.87e-10
tRNA modification in the nucleus and cytosol	33	2.79e-02	0.221000	8.16e-02
Signaling by ROBO receptors	201	7.30e-08	0.220000	2.02e-06
Defensins	36	2.24e-02	0.220000	6.97e-02
RAS processing	16	1.28e-01	0.220000	2.59e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	67	1.86e-03	0.220000	9.35e-03
Cell junction organization	78	8.06e-04	-0.219000	4.71e-03
Reduction of cytosolic Ca++ levels	11	2.08e-01	-0.219000	3.59e-01
Gene Silencing by RNA	73	1.21e-03	0.219000	6.62e-03
Cleavage of the damaged pyrimidine	16	1.30e-01	0.218000	2.61e-01
Depyrimidination	16	1.30e-01	0.218000	2.61e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	1.30e-01	0.218000	2.61e-01
Intrinsic Pathway of Fibrin Clot Formation	21	8.31e-02	-0.218000	1.91e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	1.19e-01	-0.218000	2.43e-01
GPCR ligand binding	421	1.73e-14	-0.218000	3.61e-12
Resolution of Sister Chromatid Cohesion	95	2.49e-04	0.217000	1.73e-03
SARS-CoV Infections	323	1.92e-11	0.217000	1.01e-09
Homology Directed Repair	92	3.19e-04	0.217000	2.16e-03
Processive synthesis on the C-strand of the telomere	19	1.01e-01	0.217000	2.19e-01
Mucopolysaccharidoses	10	2.36e-01	-0.216000	3.97e-01
ERK/MAPK targets	20	9.49e-02	0.216000	2.08e-01
Dermatan sulfate biosynthesis	10	2.38e-01	-0.216000	3.98e-01
RNA Polymerase III Chain Elongation	18	1.13e-01	0.215000	2.35e-01
STING mediated induction of host immune responses	13	1.81e-01	0.214000	3.27e-01
Glycolysis	66	2.60e-03	0.214000	1.25e-02
Loss of Nlp from mitotic centrosomes	59	4.44e-03	0.214000	1.92e-02
Loss of proteins required for interphase microtubule organization from the centrosome	59	4.44e-03	0.214000	1.92e-02
DSCAM interactions	11	2.20e-01	-0.214000	3.75e-01
Interferon Signaling	184	5.76e-07	0.214000	1.31e-05
Class A/1 (Rhodopsin-like receptors)	297	2.97e-10	-0.213000	1.07e-08
FRS-mediated FGFR1 signaling	23	7.80e-02	-0.212000	1.82e-01
TNF signaling	37	2.56e-02	0.212000	7.73e-02
Scavenging of heme from plasma	11	2.24e-01	-0.212000	3.82e-01
Anchoring of the basal body to the plasma membrane	83	8.82e-04	0.211000	5.04e-03
Telomere Extension By Telomerase	21	9.47e-02	0.211000	2.08e-01
IKK complex recruitment mediated by RIP1	22	8.74e-02	0.210000	1.99e-01
Regulation of HSF1-mediated heat shock response	76	1.52e-03	0.210000	8.00e-03
Cell Cycle	561	1.87e-17	0.210000	7.10e-15
Erythropoietin activates RAS	14	1.74e-01	-0.210000	3.16e-01
SUMOylation of RNA binding proteins	44	1.60e-02	0.210000	5.38e-02
Mitotic Prophase	75	1.68e-03	0.210000	8.77e-03
Activation of RAC1	11	2.29e-01	-0.210000	3.88e-01
Regulation of TP53 Activity through Methylation	16	1.48e-01	0.209000	2.84e-01
Peptide ligand-binding receptors	180	1.44e-06	-0.208000	2.80e-05
Meiosis	53	8.86e-03	0.208000	3.35e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	1.00e-01	-0.207000	2.17e-01
Netrin-1 signaling	49	1.21e-02	-0.207000	4.33e-02
Cell Cycle, Mitotic	448	6.15e-14	0.207000	9.35e-12
Activation of G protein gated Potassium channels	29	5.41e-02	-0.207000	1.37e-01
G protein gated Potassium channels	29	5.41e-02	-0.207000	1.37e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	5.41e-02	-0.207000	1.37e-01
Postmitotic nuclear pore complex (NPC) reformation	25	7.45e-02	0.206000	1.75e-01
Generation of second messenger molecules	30	5.08e-02	0.206000	1.32e-01
RNA Polymerase III Abortive And Retractive Initiation	41	2.26e-02	0.206000	7.01e-02
RNA Polymerase III Transcription	41	2.26e-02	0.206000	7.01e-02
Centrosome maturation	68	3.41e-03	0.205000	1.59e-02
Recruitment of mitotic centrosome proteins and complexes	68	3.41e-03	0.205000	1.59e-02
Na+/Cl- dependent neurotransmitter transporters	18	1.32e-01	-0.205000	2.63e-01
Cardiac conduction	119	1.10e-04	-0.205000	8.62e-04
Deposition of new CENPA-containing nucleosomes at the centromere	21	1.04e-01	0.205000	2.21e-01
Nucleosome assembly	21	1.04e-01	0.205000	2.21e-01
Chromosome Maintenance	78	1.79e-03	0.205000	9.16e-03
Mitotic Prometaphase	163	6.91e-06	0.204000	1.00e-04
Dual incision in TC-NER	62	5.56e-03	0.204000	2.28e-02
IRAK4 deficiency (TLR2/4)	17	1.46e-01	-0.203000	2.83e-01
FCERI mediated Ca+2 mobilization	27	6.77e-02	0.203000	1.62e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	99	4.78e-04	0.203000	3.08e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	16	1.60e-01	0.203000	3.01e-01
Bicarbonate transporters	10	2.67e-01	-0.203000	4.37e-01
NOD1/2 Signaling Pathway	27	6.94e-02	0.202000	1.65e-01
Telomere Maintenance	59	7.34e-03	0.202000	2.91e-02
MAPK3 (ERK1) activation	10	2.70e-01	0.201000	4.41e-01
Diseases of programmed cell death	41	2.59e-02	0.201000	7.77e-02
SUMOylation of intracellular receptors	29	6.10e-02	-0.201000	1.49e-01
Negative regulation of MAPK pathway	41	2.60e-02	0.201000	7.77e-02
Processing of DNA double-strand break ends	58	8.28e-03	0.200000	3.18e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	4.31e-02	0.200000	1.17e-01
Regulated Necrosis	52	1.24e-02	0.200000	4.44e-02
DNA Double-Strand Break Repair	121	1.44e-04	0.200000	1.09e-03
Cellular response to heat stress	93	8.66e-04	0.200000	4.98e-03
Antigen processing-Cross presentation	100	5.54e-04	0.200000	3.47e-03
CLEC7A (Dectin-1) signaling	94	8.40e-04	0.199000	4.85e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	2.89e-03	0.199000	1.37e-02
Aspartate and asparagine metabolism	12	2.36e-01	-0.198000	3.97e-01
Pausing and recovery of Tat-mediated HIV elongation	23	1.01e-01	0.198000	2.17e-01
Tat-mediated HIV elongation arrest and recovery	23	1.01e-01	0.198000	2.17e-01
N-Glycan antennae elongation	15	1.87e-01	-0.197000	3.35e-01
Transport of organic anions	10	2.81e-01	-0.197000	4.53e-01
Signal transduction by L1	20	1.28e-01	-0.197000	2.59e-01
Acyl chain remodelling of PG	17	1.64e-01	0.195000	3.05e-01
Regulation of TLR by endogenous ligand	17	1.65e-01	-0.194000	3.06e-01
Nonhomologous End-Joining (NHEJ)	30	6.54e-02	0.194000	1.58e-01
Glucose metabolism	85	1.99e-03	0.194000	9.87e-03
Collagen biosynthesis and modifying enzymes	58	1.06e-02	-0.194000	3.89e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	5.85e-02	0.193000	1.45e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	86	1.97e-03	0.193000	9.84e-03
Extension of Telomeres	45	2.52e-02	0.193000	7.65e-02
ROS and RNS production in phagocytes	35	4.85e-02	-0.193000	1.28e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	8.94e-02	0.192000	2.01e-01
Glucagon signaling in metabolic regulation	33	5.65e-02	-0.192000	1.41e-01
E3 ubiquitin ligases ubiquitinate target proteins	42	3.15e-02	0.192000	8.98e-02
Chromatin modifying enzymes	167	1.91e-05	0.192000	2.12e-04
Chromatin organization	167	1.91e-05	0.192000	2.12e-04
Advanced glycosylation endproduct receptor signaling	13	2.33e-01	0.191000	3.94e-01
RHO GTPases Activate WASPs and WAVEs	33	5.80e-02	0.191000	1.44e-01
Collagen chain trimerization	40	3.72e-02	-0.190000	1.04e-01
Asymmetric localization of PCP proteins	62	9.58e-03	0.190000	3.57e-02
Regulation of RAS by GAPs	66	7.54e-03	0.190000	2.96e-02
Collagen formation	78	3.71e-03	-0.190000	1.69e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.36e-01	-0.190000	3.97e-01
CRMPs in Sema3A signaling	15	2.03e-01	-0.190000	3.55e-01
Constitutive Signaling by AKT1 E17K in Cancer	24	1.09e-01	0.189000	2.28e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	27	8.93e-02	0.189000	2.01e-01
Regulation of KIT signaling	16	1.91e-01	0.189000	3.41e-01
Acyl chain remodelling of PI	15	2.07e-01	0.188000	3.59e-01
Regulation of TP53 Activity through Phosphorylation	86	2.61e-03	0.188000	1.25e-02
Glycosaminoglycan metabolism	111	6.32e-04	-0.188000	3.84e-03
Chondroitin sulfate/dermatan sulfate metabolism	45	2.94e-02	-0.188000	8.52e-02
Spry regulation of FGF signaling	16	1.94e-01	0.187000	3.43e-01
Downregulation of ERBB2 signaling	28	8.63e-02	-0.187000	1.97e-01
Nucleotide Excision Repair	106	8.68e-04	0.187000	4.98e-03
Cilium Assembly	159	4.93e-05	0.187000	4.33e-04
Activation of the pre-replicative complex	24	1.14e-01	0.186000	2.36e-01
RHOBTB2 GTPase cycle	21	1.40e-01	0.186000	2.75e-01
Termination of translesion DNA synthesis	31	7.31e-02	0.186000	1.72e-01
ER Quality Control Compartment (ERQC)	20	1.50e-01	0.186000	2.88e-01
Protein ubiquitination	59	1.36e-02	0.186000	4.76e-02
TRAF6 mediated IRF7 activation	20	1.51e-01	0.186000	2.89e-01
DNA Repair	262	2.39e-07	0.185000	6.06e-06
RET signaling	41	4.04e-02	-0.185000	1.12e-01
Transcriptional regulation by RUNX3	93	2.05e-03	0.185000	1.01e-02
Potential therapeutics for SARS	83	3.59e-03	0.185000	1.65e-02
MECP2 regulates neuronal receptors and channels	17	1.88e-01	-0.184000	3.36e-01
RHO GTPases Activate NADPH Oxidases	22	1.35e-01	-0.184000	2.67e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	19	1.66e-01	0.184000	3.06e-01
Peroxisomal protein import	60	1.45e-02	0.183000	4.95e-02
Synaptic adhesion-like molecules	19	1.69e-01	-0.182000	3.09e-01
Defective B3GAT3 causes JDSSDHD	17	1.94e-01	-0.182000	3.42e-01
SUMOylation of immune response proteins	10	3.20e-01	0.182000	4.89e-01
O-linked glycosylation of mucins	56	1.86e-02	-0.182000	6.03e-02
KEAP1-NFE2L2 pathway	102	1.55e-03	0.181000	8.17e-03
Neddylation	225	2.79e-06	0.181000	5.04e-05
Phosphorylation of the APC/C	18	1.85e-01	0.181000	3.32e-01
MET activates RAS signaling	11	3.00e-01	-0.181000	4.70e-01
MicroRNA (miRNA) biogenesis	21	1.53e-01	0.180000	2.92e-01
HSF1-dependent transactivation	35	6.55e-02	0.180000	1.58e-01
Interleukin-1 signaling	95	2.48e-03	0.180000	1.20e-02
APC/C:Cdc20 mediated degradation of Cyclin B	22	1.45e-01	0.179000	2.82e-01
Glutamate and glutamine metabolism	12	2.82e-01	-0.179000	4.54e-01
Pregnenolone biosynthesis	10	3.27e-01	-0.179000	4.95e-01
Recruitment of NuMA to mitotic centrosomes	67	1.14e-02	0.179000	4.14e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	28	1.02e-01	0.179000	2.19e-01
PERK regulates gene expression	30	9.16e-02	0.178000	2.05e-01
EML4 and NUDC in mitotic spindle formation	90	3.65e-03	0.177000	1.67e-02
Biosynthesis of specialized proresolving mediators (SPMs)	19	1.81e-01	-0.177000	3.27e-01
Processing of SMDT1	10	3.33e-01	0.177000	5.01e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	86	4.80e-03	0.176000	2.03e-02
Amplification of signal from the kinetochores	86	4.80e-03	0.176000	2.03e-02
Phospholipase C-mediated cascade; FGFR2	17	2.09e-01	-0.176000	3.62e-01
Regulation of RUNX2 expression and activity	71	1.04e-02	0.176000	3.84e-02
Activated NTRK2 signals through FRS2 and FRS3	11	3.13e-01	-0.176000	4.84e-01
DAP12 signaling	28	1.08e-01	0.175000	2.27e-01
NF-kB is activated and signals survival	12	2.93e-01	0.175000	4.65e-01
Triglyceride catabolism	22	1.55e-01	-0.175000	2.93e-01
Interleukin receptor SHC signaling	23	1.46e-01	0.175000	2.83e-01
Toll Like Receptor 3 (TLR3) Cascade	86	5.19e-03	0.174000	2.16e-02
RAF activation	33	8.30e-02	0.174000	1.91e-01
Elastic fibre formation	41	5.53e-02	-0.173000	1.39e-01
SUMOylation of DNA methylation proteins	16	2.31e-01	-0.173000	3.92e-01
DNA Damage Bypass	45	4.53e-02	0.172000	1.22e-01
Organelle biogenesis and maintenance	225	8.33e-06	0.172000	1.14e-04
Base-Excision Repair, AP Site Formation	18	2.05e-01	0.172000	3.58e-01
Mitotic Spindle Checkpoint	101	2.86e-03	0.172000	1.36e-02
Formation of tubulin folding intermediates by CCT/TriC	24	1.45e-01	0.172000	2.82e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	26	1.32e-01	0.171000	2.63e-01
B-WICH complex positively regulates rRNA expression	29	1.12e-01	0.170000	2.33e-01
PI-3K cascade:FGFR1	21	1.76e-01	-0.170000	3.20e-01
Beta-catenin phosphorylation cascade	16	2.38e-01	0.170000	3.98e-01
Base Excision Repair	45	4.82e-02	0.170000	1.28e-01
Epigenetic regulation of gene expression	83	7.46e-03	0.170000	2.94e-02
FCGR3A-mediated IL10 synthesis	37	7.38e-02	-0.170000	1.74e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	2.13e-01	0.170000	3.66e-01
Global Genome Nucleotide Excision Repair (GG-NER)	81	8.38e-03	0.169000	3.21e-02
CaMK IV-mediated phosphorylation of CREB	10	3.54e-01	0.169000	5.22e-01
Removal of the Flap Intermediate	13	2.91e-01	0.169000	4.62e-01
Aggrephagy	23	1.60e-01	0.169000	3.01e-01
Collagen degradation	36	7.92e-02	-0.169000	1.84e-01
APC-Cdc20 mediated degradation of Nek2A	24	1.52e-01	0.169000	2.90e-01
RHOH GTPase cycle	35	8.39e-02	0.169000	1.92e-01
NCAM signaling for neurite out-growth	56	2.90e-02	-0.169000	8.44e-02
Translation of Structural Proteins	29	1.17e-01	0.168000	2.41e-01
Regulation of RUNX1 Expression and Activity	19	2.05e-01	0.168000	3.58e-01
RNA Polymerase I Transcription Initiation	42	6.01e-02	0.168000	1.48e-01
Phospholipase C-mediated cascade; FGFR4	14	2.81e-01	-0.166000	4.53e-01
Trafficking of GluR2-containing AMPA receptors	15	2.66e-01	-0.166000	4.36e-01
HSF1 activation	27	1.37e-01	0.165000	2.71e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	8.19e-02	0.165000	1.89e-01
RNA Polymerase I Promoter Clearance	46	5.29e-02	0.165000	1.36e-01
FGFR2c ligand binding and activation	12	3.23e-01	-0.165000	4.93e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	2.14e-01	0.165000	3.67e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	2.14e-01	0.165000	3.67e-01
G alpha (q) signalling events	200	6.10e-05	-0.164000	5.18e-04
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	9.74e-02	-0.164000	2.12e-01
Uptake and actions of bacterial toxins	29	1.26e-01	-0.164000	2.56e-01
Assembly of collagen fibrils and other multimeric structures	52	4.05e-02	-0.164000	1.12e-01
Purine salvage	12	3.25e-01	0.164000	4.94e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	1.08e-01	-0.164000	2.27e-01
Cellular responses to stress	655	8.97e-13	0.164000	7.58e-11
Interaction With Cumulus Cells And The Zona Pellucida	11	3.48e-01	0.164000	5.17e-01
Signaling by WNT in cancer	32	1.10e-01	-0.163000	2.30e-01
Estrogen-dependent gene expression	87	9.15e-03	0.162000	3.44e-02
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.96e-01	0.161000	4.67e-01
Josephin domain DUBs	11	3.56e-01	0.161000	5.24e-01
WNT5A-dependent internalization of FZD4	15	2.81e-01	-0.161000	4.53e-01
Cell-Cell communication	111	3.44e-03	-0.161000	1.60e-02
WNT ligand biogenesis and trafficking	24	1.74e-01	-0.160000	3.16e-01
COPI-dependent Golgi-to-ER retrograde traffic	80	1.31e-02	0.160000	4.61e-02
RMTs methylate histone arginines	29	1.35e-01	0.160000	2.67e-01
Digestion and absorption	25	1.66e-01	0.160000	3.06e-01
ECM proteoglycans	55	4.03e-02	-0.160000	1.11e-01
Signaling by ERBB2 KD Mutants	24	1.76e-01	-0.160000	3.19e-01
SUMOylation of DNA damage response and repair proteins	70	2.09e-02	0.160000	6.64e-02
HS-GAG degradation	18	2.41e-01	-0.160000	4.02e-01
Cytosolic iron-sulfur cluster assembly	10	3.82e-01	0.159000	5.49e-01
Retrograde neurotrophin signalling	14	3.02e-01	-0.159000	4.72e-01
Extracellular matrix organization	276	5.81e-06	-0.159000	8.91e-05
Regulation of TP53 Activity through Acetylation	28	1.47e-01	0.158000	2.83e-01
Regulation of MECP2 expression and activity	26	1.62e-01	0.158000	3.04e-01
ADORA2B mediated anti-inflammatory cytokines production	132	1.70e-03	-0.158000	8.80e-03
Regulation of pyruvate dehydrogenase (PDH) complex	14	3.06e-01	-0.158000	4.77e-01
Transcriptional activation of mitochondrial biogenesis	48	5.92e-02	0.157000	1.46e-01
Deubiquitination	222	5.50e-05	0.157000	4.78e-04
CD209 (DC-SIGN) signaling	20	2.25e-01	-0.157000	3.83e-01
DNA Double Strand Break Response	41	8.47e-02	0.156000	1.93e-01
Phospholipase C-mediated cascade; FGFR3	12	3.51e-01	-0.155000	5.20e-01
TGF-beta receptor signaling activates SMADs	45	7.12e-02	0.155000	1.68e-01
Post-chaperonin tubulin folding pathway	21	2.18e-01	0.155000	3.73e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	177	3.76e-04	0.155000	2.49e-03
Dissolution of Fibrin Clot	13	3.34e-01	-0.155000	5.01e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	40	9.14e-02	0.154000	2.05e-01
TNFs bind their physiological receptors	24	1.91e-01	0.154000	3.40e-01
Muscle contraction	185	3.02e-04	-0.154000	2.07e-03
RHO GTPases Activate Formins	111	5.14e-03	0.154000	2.15e-02
GPER1 signaling	43	8.18e-02	-0.153000	1.89e-01
Tight junction interactions	28	1.60e-01	-0.153000	3.01e-01
Cellular responses to stimuli	669	1.53e-11	0.153000	8.33e-10
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	3.79e-01	-0.153000	5.47e-01
MET activates PTK2 signaling	18	2.61e-01	-0.153000	4.31e-01
Signaling by Non-Receptor Tyrosine Kinases	53	5.49e-02	-0.152000	1.38e-01
Signaling by PTK6	53	5.49e-02	-0.152000	1.38e-01
Syndecan interactions	19	2.51e-01	-0.152000	4.15e-01
Signaling by GPCR	640	5.32e-11	-0.152000	2.25e-09
MyD88 cascade initiated on plasma membrane	77	2.11e-02	0.152000	6.66e-02
Toll Like Receptor 10 (TLR10) Cascade	77	2.11e-02	0.152000	6.66e-02
Toll Like Receptor 5 (TLR5) Cascade	77	2.11e-02	0.152000	6.66e-02
Golgi-to-ER retrograde transport	114	5.05e-03	0.152000	2.11e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	3.63e-01	-0.152000	5.31e-01
G alpha (s) signalling events	152	1.26e-03	-0.152000	6.83e-03
Calnexin/calreticulin cycle	25	1.91e-01	0.151000	3.40e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	28	1.68e-01	0.150000	3.09e-01
Constitutive Signaling by EGFRvIII	15	3.15e-01	0.150000	4.84e-01
Signaling by EGFRvIII in Cancer	15	3.15e-01	0.150000	4.84e-01
Triglyceride metabolism	34	1.30e-01	-0.150000	2.61e-01
Defective Intrinsic Pathway for Apoptosis	25	1.95e-01	0.150000	3.43e-01
Cholesterol biosynthesis	22	2.25e-01	0.149000	3.83e-01
Arachidonic acid metabolism	56	5.30e-02	-0.149000	1.36e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	3.19e-01	0.149000	4.89e-01
Hedgehog ‘off’ state	97	1.17e-02	0.148000	4.22e-02
COPI-mediated anterograde transport	82	2.12e-02	0.147000	6.68e-02
VEGFR2 mediated vascular permeability	26	1.95e-01	-0.147000	3.44e-01
G alpha (z) signalling events	48	7.91e-02	-0.146000	1.84e-01
Recognition of DNA damage by PCNA-containing replication complex	29	1.74e-01	0.146000	3.17e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	4.03e-01	0.146000	5.70e-01
Transcriptional Regulation by MECP2	55	6.18e-02	-0.146000	1.50e-01
XBP1(S) activates chaperone genes	47	8.45e-02	0.145000	1.93e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	50	7.53e-02	0.145000	1.76e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	3.00e-01	0.145000	4.70e-01
MyD88-independent TLR4 cascade	90	1.76e-02	0.145000	5.77e-02
TRIF(TICAM1)-mediated TLR4 signaling	90	1.76e-02	0.145000	5.77e-02
Unwinding of DNA	11	4.06e-01	0.145000	5.73e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	3.34e-01	-0.144000	5.01e-01
DNA strand elongation	30	1.72e-01	0.144000	3.14e-01
Infectious disease	862	8.85e-13	0.144000	7.58e-11
Lagging Strand Synthesis	19	2.79e-01	0.144000	4.50e-01
FLT3 signaling in disease	28	1.90e-01	0.143000	3.39e-01
CD28 dependent PI3K/Akt signaling	22	2.48e-01	0.142000	4.11e-01
G-protein mediated events	52	7.60e-02	-0.142000	1.78e-01
Transcription of E2F targets under negative control by DREAM complex	19	2.83e-01	0.142000	4.54e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	4.14e-01	0.142000	5.80e-01
Constitutive Signaling by Aberrant PI3K in Cancer	76	3.25e-02	-0.142000	9.23e-02
Cytokine Signaling in Immune system	641	9.21e-10	0.142000	2.98e-08
FRS-mediated FGFR2 signaling	24	2.29e-01	-0.142000	3.89e-01
Cellular Senescence	122	6.84e-03	0.142000	2.74e-02
TBC/RABGAPs	42	1.13e-01	0.141000	2.34e-01
G alpha (i) signalling events	293	3.15e-05	-0.141000	3.03e-04
Inactivation of APC/C via direct inhibition of the APC/C complex	19	2.88e-01	0.141000	4.59e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	2.88e-01	0.141000	4.59e-01
RNA Polymerase I Transcription	47	9.58e-02	0.140000	2.10e-01
Regulated proteolysis of p75NTR	11	4.20e-01	0.140000	5.86e-01
Antigen processing: Ubiquitination & Proteasome degradation	286	4.45e-05	0.140000	4.00e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	3.47e-01	0.140000	5.17e-01
Gluconeogenesis	32	1.71e-01	0.140000	3.13e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	4.02e-01	0.140000	5.70e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	2.37e-01	-0.139000	3.98e-01
Transcriptional Regulation by TP53	321	1.87e-05	0.139000	2.12e-04
Cytochrome P450 - arranged by substrate type	64	5.48e-02	-0.139000	1.38e-01
GPCR downstream signalling	581	1.13e-08	-0.139000	3.38e-07
Chaperone Mediated Autophagy	19	2.97e-01	0.138000	4.67e-01
Regulation of insulin secretion	77	3.63e-02	-0.138000	1.02e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	47	1.02e-01	0.138000	2.19e-01
Signaling by TGF-beta Receptor Complex	86	2.73e-02	0.138000	8.03e-02
Regulation of TP53 Expression and Degradation	37	1.48e-01	0.138000	2.84e-01
Diseases associated with glycosaminoglycan metabolism	36	1.54e-01	-0.137000	2.92e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	40	1.33e-01	0.137000	2.65e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	81	3.37e-02	0.136000	9.52e-02
Detoxification of Reactive Oxygen Species	34	1.69e-01	-0.136000	3.09e-01
Mitochondrial biogenesis	66	5.61e-02	0.136000	1.41e-01
Unfolded Protein Response (UPR)	86	2.97e-02	0.136000	8.55e-02
Formation of Incision Complex in GG-NER	40	1.38e-01	0.135000	2.72e-01
Meiotic synapsis	29	2.07e-01	0.135000	3.59e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	9.14e-02	-0.135000	2.05e-01
FLT3 Signaling	38	1.50e-01	0.135000	2.88e-01
Reproduction	75	4.43e-02	0.134000	1.20e-01
Signaling by NOTCH	176	2.14e-03	0.134000	1.05e-02
Keratan sulfate degradation	10	4.63e-01	0.134000	6.27e-01
MAP kinase activation	56	8.37e-02	0.134000	1.92e-01
Regulation of TP53 Degradation	36	1.66e-01	0.133000	3.06e-01
Oxidative Stress Induced Senescence	62	6.95e-02	0.133000	1.65e-01
Metabolism of amino acids and derivatives	339	2.52e-05	0.133000	2.56e-04
Assembly of active LPL and LIPC lipase complexes	17	3.42e-01	0.133000	5.12e-01
Uptake and function of anthrax toxins	11	4.50e-01	0.132000	6.16e-01
COPI-independent Golgi-to-ER retrograde traffic	34	1.86e-01	0.131000	3.33e-01
MyD88 dependent cascade initiated on endosome	82	4.07e-02	0.131000	1.12e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	82	4.07e-02	0.131000	1.12e-01
FRS-mediated FGFR4 signaling	21	3.00e-01	-0.131000	4.70e-01
Glycogen breakdown (glycogenolysis)	12	4.34e-01	0.130000	5.99e-01
Downregulation of ERBB2:ERBB3 signaling	13	4.16e-01	-0.130000	5.82e-01
Interleukin-4 and Interleukin-13 signaling	102	2.32e-02	0.130000	7.15e-02
Cargo trafficking to the periciliary membrane	48	1.20e-01	0.130000	2.45e-01
Signaling by FGFR2	71	5.87e-02	0.130000	1.45e-01
Regulation of innate immune responses to cytosolic DNA	14	4.01e-01	0.130000	5.70e-01
RHOBTB GTPase Cycle	33	1.98e-01	0.130000	3.47e-01
RHO GTPases activate CIT	19	3.29e-01	0.129000	4.97e-01
Nicotinamide salvaging	16	3.72e-01	0.129000	5.39e-01
Selective autophagy	58	8.94e-02	0.129000	2.01e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	4.43e-03	-0.129000	1.92e-02
Leishmania parasite growth and survival	164	4.43e-03	-0.129000	1.92e-02
Metalloprotease DUBs	18	3.44e-01	0.129000	5.15e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	3.73e-01	0.129000	5.40e-01
Purine catabolism	15	3.88e-01	0.129000	5.56e-01
Intra-Golgi traffic	41	1.54e-01	0.129000	2.93e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	3.33e-01	0.128000	5.01e-01
Keratan sulfate biosynthesis	25	2.67e-01	-0.128000	4.36e-01
Hedgehog ‘on’ state	83	4.38e-02	0.128000	1.18e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	1.51e-01	-0.128000	2.89e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	3.91e-01	0.128000	5.59e-01
Toll Like Receptor 9 (TLR9) Cascade	85	4.24e-02	0.127000	1.15e-01
PTEN Regulation	141	9.07e-03	0.127000	3.42e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	3.50e-01	0.127000	5.18e-01
Signaling by ERBB2 in Cancer	25	2.71e-01	-0.127000	4.41e-01
Interferon gamma signaling	89	3.82e-02	0.127000	1.06e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	3.26e-01	0.127000	4.94e-01
Notch-HLH transcription pathway	24	2.82e-01	0.127000	4.53e-01
Interleukin-1 family signaling	126	1.41e-02	0.127000	4.86e-02
Disorders of Developmental Biology	11	4.68e-01	0.126000	6.30e-01
Disorders of Nervous System Development	11	4.68e-01	0.126000	6.30e-01
Loss of function of MECP2 in Rett syndrome	11	4.68e-01	0.126000	6.30e-01
Pervasive developmental disorders	11	4.68e-01	0.126000	6.30e-01
Regulation of actin dynamics for phagocytic cup formation	58	9.65e-02	0.126000	2.10e-01
RORA activates gene expression	16	3.82e-01	-0.126000	5.49e-01
RUNX3 regulates NOTCH signaling	13	4.33e-01	0.126000	5.98e-01
RHO GTPases activate KTN1	11	4.71e-01	0.125000	6.33e-01
Condensation of Prophase Chromosomes	12	4.52e-01	0.125000	6.17e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	4.34e-01	0.125000	5.99e-01
Lewis blood group biosynthesis	18	3.58e-01	-0.125000	5.26e-01
IRE1alpha activates chaperones	49	1.32e-01	0.124000	2.64e-01
Protein folding	94	3.75e-02	0.124000	1.04e-01
Integration of energy metabolism	106	2.76e-02	-0.124000	8.11e-02
Pyrimidine salvage	10	4.98e-01	-0.124000	6.59e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	100	3.27e-02	-0.124000	9.27e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.86e-01	0.123000	4.57e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	1.57e-01	0.123000	2.96e-01
Chaperonin-mediated protein folding	88	4.60e-02	0.123000	1.24e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	1.68e-01	-0.123000	3.09e-01
PLC beta mediated events	47	1.44e-01	-0.123000	2.82e-01
Regulation of TP53 Activity	149	9.77e-03	0.123000	3.63e-02
Defective C1GALT1C1 causes TNPS	15	4.12e-01	0.122000	5.79e-01
RHOU GTPase cycle	35	2.11e-01	0.122000	3.64e-01
Pyrimidine catabolism	11	4.83e-01	-0.122000	6.45e-01
cGMP effects	15	4.13e-01	-0.122000	5.80e-01
Disorders of transmembrane transporters	166	6.77e-03	0.122000	2.71e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	4.14e-01	-0.122000	5.80e-01
Free fatty acids regulate insulin secretion	10	5.06e-01	-0.122000	6.68e-01
Sensory perception of taste	45	1.58e-01	-0.122000	2.98e-01
IGF1R signaling cascade	51	1.34e-01	-0.121000	2.66e-01
Biosynthesis of DHA-derived SPMs	17	3.87e-01	-0.121000	5.55e-01
MET activates RAP1 and RAC1	11	4.86e-01	0.121000	6.47e-01
GPVI-mediated activation cascade	32	2.36e-01	0.121000	3.97e-01
C-type lectin receptors (CLRs)	131	1.67e-02	0.121000	5.57e-02
Regulation of IFNG signaling	14	4.33e-01	0.121000	5.98e-01
Defects in cobalamin (B12) metabolism	12	4.70e-01	0.121000	6.32e-01
Dual Incision in GG-NER	39	1.93e-01	0.120000	3.42e-01
Class I MHC mediated antigen processing & presentation	353	1.03e-04	0.120000	8.13e-04
FRS-mediated FGFR3 signaling	19	3.65e-01	-0.120000	5.33e-01
ER to Golgi Anterograde Transport	130	1.82e-02	0.120000	5.94e-02
IRS-related events triggered by IGF1R	50	1.43e-01	-0.120000	2.80e-01
DCC mediated attractive signaling	14	4.39e-01	-0.120000	6.03e-01
Signaling by Interleukins	411	3.28e-05	0.119000	3.13e-04
Cyclin D associated events in G1	46	1.64e-01	0.119000	3.05e-01
G1 Phase	46	1.64e-01	0.119000	3.05e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	3.14e-01	0.119000	4.84e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	2.97e-01	-0.118000	4.67e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	3.38e-01	0.118000	5.06e-01
Neurodegenerative Diseases	22	3.38e-01	0.118000	5.06e-01
Growth hormone receptor signaling	24	3.17e-01	0.118000	4.86e-01
SARS-CoV-1 Infection	49	1.54e-01	0.118000	2.92e-01
STAT5 activation downstream of FLT3 ITD mutants	10	5.19e-01	0.118000	6.78e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.92e-01	0.118000	3.41e-01
Signaling by RAS mutants	41	1.92e-01	0.118000	3.41e-01
Signaling by moderate kinase activity BRAF mutants	41	1.92e-01	0.118000	3.41e-01
Signaling downstream of RAS mutants	41	1.92e-01	0.118000	3.41e-01
Peptide hormone metabolism	80	6.96e-02	-0.117000	1.65e-01
Downstream signaling of activated FGFR1	31	2.58e-01	-0.117000	4.27e-01
Kinesins	42	1.89e-01	0.117000	3.37e-01
Signaling by Leptin	11	5.05e-01	0.116000	6.67e-01
G0 and Early G1	27	2.98e-01	0.116000	4.68e-01
Asparagine N-linked glycosylation	273	1.01e-03	0.116000	5.65e-03
G-protein activation	24	3.27e-01	-0.116000	4.95e-01
Nuclear Receptor transcription pathway	51	1.56e-01	-0.115000	2.94e-01
Death Receptor Signalling	120	3.02e-02	0.115000	8.66e-02
L1CAM interactions	91	5.92e-02	-0.114000	1.46e-01
Translesion Synthesis by POLH	18	4.01e-01	0.114000	5.70e-01
Toll-like Receptor Cascades	138	2.13e-02	0.114000	6.69e-02
Transcriptional Regulation by E2F6	32	2.66e-01	0.113000	4.36e-01
Positive epigenetic regulation of rRNA expression	43	2.01e-01	0.113000	3.51e-01
PCNA-Dependent Long Patch Base Excision Repair	21	3.71e-01	0.113000	5.39e-01
SUMOylation of transcription factors	20	3.87e-01	-0.112000	5.55e-01
Phase 0 - rapid depolarisation	31	2.83e-01	-0.111000	4.54e-01
trans-Golgi Network Vesicle Budding	65	1.20e-01	0.111000	2.45e-01
PCP/CE pathway	90	6.86e-02	0.111000	1.64e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	3.02e-01	-0.111000	4.72e-01
Trafficking of AMPA receptors	29	3.02e-01	-0.111000	4.72e-01
Apoptotic cleavage of cellular proteins	34	2.66e-01	-0.110000	4.36e-01
Regulation of signaling by CBL	18	4.20e-01	0.110000	5.86e-01
Eicosanoids	12	5.11e-01	0.110000	6.74e-01
Synthesis of IP3 and IP4 in the cytosol	25	3.45e-01	-0.109000	5.15e-01
eNOS activation	11	5.33e-01	0.109000	6.91e-01
FCERI mediated MAPK activation	29	3.12e-01	0.109000	4.84e-01
Processive synthesis on the lagging strand	14	4.83e-01	0.108000	6.44e-01
Nicotinate metabolism	25	3.48e-01	0.108000	5.17e-01
IRS-mediated signalling	47	2.00e-01	-0.108000	3.50e-01
Acyl chain remodelling of PS	20	4.03e-01	0.108000	5.70e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	1.11e-01	0.108000	2.32e-01
Basigin interactions	24	3.62e-01	0.108000	5.30e-01
RHO GTPases activate IQGAPs	11	5.37e-01	-0.108000	6.92e-01
Oncogene Induced Senescence	32	2.94e-01	0.107000	4.66e-01
Cell recruitment (pro-inflammatory response)	25	3.54e-01	-0.107000	5.22e-01
Purinergic signaling in leishmaniasis infection	25	3.54e-01	-0.107000	5.22e-01
Insulin receptor signalling cascade	53	1.78e-01	-0.107000	3.23e-01
Interleukin-7 signaling	21	3.97e-01	0.107000	5.66e-01
COPII-mediated vesicle transport	63	1.44e-01	0.106000	2.80e-01
Molecules associated with elastic fibres	30	3.13e-01	-0.106000	4.84e-01
Signaling by cytosolic FGFR1 fusion mutants	16	4.62e-01	0.106000	6.27e-01
Degradation of the extracellular matrix	103	6.30e-02	-0.106000	1.52e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	9.37e-02	-0.106000	2.07e-01
RNA Polymerase III Transcription Termination	23	3.80e-01	0.106000	5.48e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	5.44e-01	0.106000	6.99e-01
Downregulation of TGF-beta receptor signaling	26	3.53e-01	0.105000	5.22e-01
Signaling by BMP	27	3.48e-01	-0.104000	5.17e-01
Translesion synthesis by POLI	17	4.57e-01	0.104000	6.21e-01
Resolution of Abasic Sites (AP sites)	37	2.73e-01	0.104000	4.43e-01
Triglyceride biosynthesis	12	5.34e-01	-0.104000	6.92e-01
Adrenaline,noradrenaline inhibits insulin secretion	28	3.46e-01	-0.103000	5.15e-01
Organic cation/anion/zwitterion transport	15	4.90e-01	0.103000	6.52e-01
Zinc influx into cells by the SLC39 gene family	10	5.74e-01	-0.103000	7.19e-01
SUMOylation of chromatin organization proteins	53	1.96e-01	0.103000	3.45e-01
Aquaporin-mediated transport	51	2.06e-01	-0.102000	3.58e-01
Non-integrin membrane-ECM interactions	40	2.62e-01	-0.102000	4.31e-01
NOTCH2 intracellular domain regulates transcription	11	5.57e-01	0.102000	7.11e-01
Activation of Matrix Metalloproteinases	30	3.33e-01	-0.102000	5.01e-01
Mitophagy	26	3.68e-01	0.102000	5.36e-01
Ethanol oxidation	11	5.58e-01	-0.102000	7.11e-01
Organic anion transporters	10	5.77e-01	0.102000	7.22e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	4.55e-01	0.102000	6.20e-01
RUNX2 regulates osteoblast differentiation	22	4.10e-01	-0.101000	5.77e-01
Xenobiotics	24	3.90e-01	-0.101000	5.58e-01
Fanconi Anemia Pathway	31	3.29e-01	0.101000	4.97e-01
CaM pathway	33	3.15e-01	-0.101000	4.84e-01
Calmodulin induced events	33	3.15e-01	-0.101000	4.84e-01
Programmed Cell Death	190	1.68e-02	0.101000	5.57e-02
Adaptive Immune System	697	6.85e-06	0.100000	1.00e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	12	5.51e-01	0.099500	7.06e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	5.51e-01	0.099300	7.06e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.92e-01	0.099200	6.52e-01
Regulation of BACH1 activity	14	5.21e-01	0.099200	6.79e-01
Cytoprotection by HMOX1	55	2.05e-01	0.098900	3.57e-01
Abacavir ADME	10	5.88e-01	-0.098900	7.30e-01
Blood group systems biosynthesis	22	4.22e-01	-0.098800	5.88e-01
Apoptosis	163	2.97e-02	0.098700	8.55e-02
Sema3A PAK dependent Axon repulsion	14	5.23e-01	-0.098700	6.81e-01
Activation of the phototransduction cascade	11	5.73e-01	-0.098100	7.19e-01
Hyaluronan uptake and degradation	11	5.74e-01	0.097900	7.19e-01
Diseases of glycosylation	129	5.48e-02	-0.097900	1.38e-01
Cellular response to chemical stress	182	2.32e-02	0.097600	7.15e-02
Platelet Aggregation (Plug Formation)	37	3.05e-01	-0.097500	4.75e-01
Incretin synthesis, secretion, and inactivation	22	4.28e-01	-0.097500	5.94e-01
Ion homeostasis	49	2.38e-01	-0.097400	3.98e-01
Gap junction assembly	18	4.77e-01	-0.096800	6.38e-01
Metabolic disorders of biological oxidation enzymes	32	3.46e-01	-0.096300	5.15e-01
Defective GALNT12 causes CRCS1	15	5.19e-01	0.096200	6.78e-01
Signaling by ERBB2	49	2.44e-01	-0.096100	4.07e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	5.66e-01	-0.095700	7.18e-01
Regulation of PTEN mRNA translation	21	4.48e-01	0.095600	6.14e-01
Diseases of mitotic cell cycle	35	3.28e-01	0.095500	4.97e-01
PI-3K cascade:FGFR2	22	4.38e-01	-0.095400	6.03e-01
Cargo concentration in the ER	31	3.59e-01	0.095100	5.28e-01
Retrograde transport at the Trans-Golgi-Network	45	2.72e-01	0.094600	4.41e-01
Aflatoxin activation and detoxification	20	4.65e-01	-0.094300	6.30e-01
Activation of AMPK downstream of NMDARs	10	6.06e-01	-0.094100	7.44e-01
PI3K Cascade	43	2.88e-01	-0.093500	4.59e-01
Metabolism of proteins	1717	1.43e-10	0.093400	5.71e-09
VEGFR2 mediated cell proliferation	19	4.81e-01	-0.093300	6.43e-01
EPH-ephrin mediated repulsion of cells	48	2.64e-01	-0.093300	4.33e-01
Defective GALNT3 causes HFTC	15	5.32e-01	0.093100	6.90e-01
Synthesis of PE	11	5.93e-01	0.093000	7.33e-01
Chylomicron assembly	10	6.12e-01	0.092700	7.50e-01
Synthesis of very long-chain fatty acyl-CoAs	19	4.84e-01	-0.092600	6.45e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	5.36e-01	0.092200	6.92e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	5.65e-01	-0.092200	7.18e-01
FCGR3A-mediated phagocytosis	56	2.34e-01	0.091900	3.95e-01
Leishmania phagocytosis	56	2.34e-01	0.091900	3.95e-01
Parasite infection	56	2.34e-01	0.091900	3.95e-01
Toll Like Receptor 4 (TLR4) Cascade	122	8.01e-02	0.091700	1.86e-01
TP53 Regulates Metabolic Genes	71	1.82e-01	0.091700	3.27e-01
Translesion synthesis by REV1	16	5.26e-01	0.091600	6.84e-01
Suppression of phagosomal maturation	13	5.68e-01	0.091300	7.18e-01
Heme biosynthesis	13	5.69e-01	-0.091300	7.18e-01
Opioid Signalling	88	1.39e-01	-0.091200	2.74e-01
SLC-mediated transmembrane transport	235	1.63e-02	-0.091000	5.44e-02
Chemokine receptors bind chemokines	52	2.57e-01	-0.090900	4.25e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	52	2.57e-01	0.090900	4.25e-01
Scavenging by Class A Receptors	19	4.93e-01	0.090900	6.53e-01
Transport to the Golgi and subsequent modification	161	4.73e-02	0.090600	1.26e-01
Phase I - Functionalization of compounds	98	1.21e-01	-0.090600	2.47e-01
IL-6-type cytokine receptor ligand interactions	17	5.19e-01	-0.090300	6.78e-01
Regulation of lipid metabolism by PPARalpha	115	9.49e-02	0.090200	2.08e-01
RHO GTPases activate PKNs	34	3.63e-01	0.090100	5.31e-01
Presynaptic nicotinic acetylcholine receptors	12	5.89e-01	0.090100	7.30e-01
Glycogen synthesis	15	5.47e-01	0.089900	7.01e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	115	9.62e-02	-0.089800	2.10e-01
Synthesis of PA	34	3.69e-01	0.089000	5.37e-01
PRC2 methylates histones and DNA	13	5.79e-01	0.088800	7.24e-01
RHOV GTPase cycle	34	3.71e-01	0.088700	5.39e-01
TAK1-dependent IKK and NF-kappa-B activation	23	4.63e-01	0.088300	6.28e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	2.72e-01	0.087200	4.41e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	2.72e-01	0.087200	4.41e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	2.72e-01	0.087200	4.41e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	2.72e-01	0.087200	4.41e-01
Signaling by NOTCH1 in Cancer	53	2.72e-01	0.087200	4.41e-01
FGFR2 ligand binding and activation	19	5.13e-01	-0.086700	6.76e-01
Signaling by FGFR3 in disease	21	4.92e-01	-0.086600	6.52e-01
Senescence-Associated Secretory Phenotype (SASP)	49	2.96e-01	0.086300	4.67e-01
Killing mechanisms	11	6.22e-01	0.086000	7.56e-01
WNT5:FZD7-mediated leishmania damping	11	6.22e-01	0.086000	7.56e-01
Regulation of localization of FOXO transcription factors	10	6.38e-01	-0.085900	7.66e-01
Regulation of gene expression by Hypoxia-inducible Factor	11	6.22e-01	-0.085800	7.56e-01
PIWI-interacting RNA (piRNA) biogenesis	28	4.33e-01	0.085700	5.98e-01
Negative regulation of FGFR1 signaling	32	4.02e-01	-0.085600	5.70e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	4.68e-01	0.085500	6.30e-01
EPHB-mediated forward signaling	33	3.96e-01	0.085400	5.65e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	3.29e-01	0.085100	4.97e-01
G1/S-Specific Transcription	26	4.53e-01	0.085100	6.18e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	5.97e-01	0.084800	7.34e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	4.56e-01	0.084400	6.21e-01
Signaling by Activin	15	5.72e-01	-0.084400	7.19e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	39	3.65e-01	-0.083800	5.33e-01
CYP2E1 reactions	11	6.30e-01	-0.083800	7.62e-01
MAP2K and MAPK activation	33	4.06e-01	0.083600	5.73e-01
Prostacyclin signalling through prostacyclin receptor	19	5.28e-01	-0.083600	6.86e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	35	3.92e-01	-0.083500	5.60e-01
Interleukin-27 signaling	11	6.33e-01	0.083200	7.63e-01
Immune System	1803	5.69e-09	0.083000	1.73e-07
RHOQ GTPase cycle	53	2.96e-01	-0.083000	4.67e-01
RHO GTPase Effectors	228	3.15e-02	0.082700	8.98e-02
Endogenous sterols	26	4.67e-01	-0.082400	6.30e-01
Signal amplification	33	4.14e-01	-0.082200	5.80e-01
RND1 GTPase cycle	40	3.75e-01	0.081000	5.43e-01
Sphingolipid de novo biosynthesis	33	4.24e-01	0.080400	5.90e-01
Apoptotic execution phase	42	3.68e-01	-0.080300	5.36e-01
SUMO E3 ligases SUMOylate target proteins	157	8.30e-02	0.080200	1.91e-01
Beta-catenin independent WNT signaling	140	1.04e-01	0.079500	2.21e-01
Glucagon-type ligand receptors	33	4.30e-01	-0.079400	5.95e-01
Ephrin signaling	17	5.71e-01	0.079300	7.19e-01
Intrinsic Pathway for Apoptosis	52	3.24e-01	0.079100	4.93e-01
Frs2-mediated activation	12	6.36e-01	0.079000	7.65e-01
Pentose phosphate pathway	11	6.50e-01	0.079000	7.75e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.50e-01	0.078900	7.75e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	4.80e-01	0.078600	6.41e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	34	4.28e-01	0.078500	5.94e-01
Signaling by high-kinase activity BRAF mutants	32	4.43e-01	0.078300	6.09e-01
TRAF3-dependent IRF activation pathway	14	6.13e-01	0.078000	7.51e-01
Inflammasomes	21	5.36e-01	0.078000	6.92e-01
Platelet homeostasis	85	2.14e-01	-0.077900	3.67e-01
Signaling by Insulin receptor	76	2.40e-01	-0.077900	4.01e-01
Disease	1582	2.79e-07	0.077700	6.96e-06
p75 NTR receptor-mediated signalling	83	2.22e-01	0.077500	3.79e-01
PPARA activates gene expression	113	1.55e-01	0.077500	2.93e-01
Transcriptional regulation by RUNX1	169	8.31e-02	0.077300	1.91e-01
SUMOylation	163	8.92e-02	0.077200	2.01e-01
Insulin processing	24	5.14e-01	0.076900	6.76e-01
Assembly Of The HIV Virion	14	6.20e-01	0.076600	7.55e-01
Interleukin-17 signaling	64	2.92e-01	0.076200	4.63e-01
Keratan sulfate/keratin metabolism	30	4.70e-01	-0.076200	6.32e-01
CD28 co-stimulation	32	4.57e-01	0.076000	6.21e-01
FCGR activation	12	6.49e-01	-0.076000	7.74e-01
PI-3K cascade:FGFR4	19	5.67e-01	-0.075900	7.18e-01
Pyroptosis	25	5.14e-01	0.075500	6.76e-01
activated TAK1 mediates p38 MAPK activation	14	6.25e-01	-0.075400	7.58e-01
Integrin cell surface interactions	66	2.91e-01	-0.075200	4.62e-01
Translesion synthesis by POLK	17	5.93e-01	0.074900	7.33e-01
Diseases of signal transduction by growth factor receptors and second messengers	405	1.03e-02	0.074400	3.79e-02
Signaling by RAF1 mutants	37	4.37e-01	0.073800	6.03e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	13	6.47e-01	-0.073300	7.74e-01
Ca-dependent events	35	4.55e-01	-0.073000	6.20e-01
RHOJ GTPase cycle	48	3.82e-01	-0.072900	5.49e-01
p75NTR signals via NF-kB	15	6.26e-01	0.072800	7.58e-01
Sensory processing of sound	66	3.10e-01	-0.072200	4.83e-01
RHOBTB1 GTPase cycle	22	5.58e-01	0.072200	7.11e-01
Metabolism of nucleotides	87	2.45e-01	0.072100	4.07e-01
Leishmania infection	244	5.26e-02	-0.072100	1.36e-01
ADP signalling through P2Y purinoceptor 12	22	5.59e-01	-0.072000	7.11e-01
TP53 Regulates Transcription of Cell Death Genes	41	4.25e-01	-0.072000	5.90e-01
Defects in vitamin and cofactor metabolism	20	5.81e-01	0.071400	7.25e-01
RAB GEFs exchange GTP for GDP on RABs	72	2.95e-01	-0.071300	4.67e-01
Signaling by CSF3 (G-CSF)	28	5.17e-01	0.070700	6.78e-01
Azathioprine ADME	22	5.68e-01	0.070300	7.18e-01
Tryptophan catabolism	12	6.74e-01	-0.070200	7.93e-01
Platelet degranulation	114	1.96e-01	-0.070100	3.45e-01
Interleukin-20 family signaling	22	5.70e-01	0.069900	7.19e-01
Gene expression (Transcription)	1332	1.96e-05	0.069900	2.16e-04
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	6.52e-01	0.069700	7.76e-01
Repression of WNT target genes	13	6.65e-01	0.069300	7.87e-01
Pre-NOTCH Transcription and Translation	40	4.52e-01	0.068800	6.17e-01
RUNX2 regulates bone development	29	5.24e-01	-0.068300	6.83e-01
Rap1 signalling	16	6.36e-01	0.068300	7.65e-01
Phenylalanine and tyrosine metabolism	10	7.11e-01	-0.067700	8.20e-01
Response to elevated platelet cytosolic Ca2+	119	2.03e-01	-0.067500	3.55e-01
Carboxyterminal post-translational modifications of tubulin	35	4.90e-01	-0.067500	6.51e-01
Sulfur amino acid metabolism	27	5.44e-01	-0.067400	6.99e-01
Passive transport by Aquaporins	13	6.74e-01	0.067300	7.93e-01
Macroautophagy	100	2.46e-01	0.067200	4.08e-01
DAG and IP3 signaling	39	4.72e-01	-0.066600	6.33e-01
Golgi Associated Vesicle Biogenesis	49	4.22e-01	0.066300	5.88e-01
Hemostasis	547	8.60e-03	-0.065800	3.28e-02
Fatty acid metabolism	160	1.51e-01	-0.065700	2.89e-01
Inactivation of CSF3 (G-CSF) signaling	23	5.86e-01	0.065700	7.29e-01
Drug ADME	94	2.76e-01	-0.065000	4.47e-01
PIP3 activates AKT signaling	264	6.95e-02	0.064900	1.65e-01
Innate Immune System	952	7.50e-04	0.064600	4.42e-03
Gastrin-CREB signalling pathway via PKC and MAPK	17	6.47e-01	-0.064100	7.74e-01
Zinc transporters	17	6.48e-01	0.064000	7.74e-01
Acyl chain remodelling of PE	23	5.95e-01	0.064000	7.34e-01
Androgen biosynthesis	11	7.15e-01	0.063500	8.23e-01
Biological oxidations	210	1.13e-01	-0.063400	2.35e-01
Interleukin-6 family signaling	24	5.93e-01	0.063000	7.33e-01
Diseases of metabolism	226	1.04e-01	-0.062800	2.21e-01
Inositol phosphate metabolism	43	4.77e-01	-0.062700	6.38e-01
Post-translational protein phosphorylation	98	2.83e-01	-0.062700	4.54e-01
Negative regulation of the PI3K/AKT network	110	2.61e-01	-0.062100	4.30e-01
ADP signalling through P2Y purinoceptor 1	25	5.93e-01	-0.061700	7.33e-01
RHOC GTPase cycle	63	3.99e-01	0.061500	5.67e-01
MHC class II antigen presentation	102	2.84e-01	0.061400	4.54e-01
Platelet activation, signaling and aggregation	244	9.87e-02	-0.061400	2.14e-01
VLDLR internalisation and degradation	16	6.71e-01	-0.061300	7.91e-01
Signaling by FGFR4 in disease	11	7.25e-01	0.061200	8.29e-01
Signaling by Erythropoietin	25	5.98e-01	-0.061000	7.35e-01
Circadian Clock	67	3.90e-01	-0.060800	5.58e-01
Glucuronidation	23	6.15e-01	0.060600	7.53e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	6.65e-01	0.060600	7.87e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	92	3.16e-01	0.060500	4.84e-01
Toll Like Receptor 2 (TLR2) Cascade	92	3.16e-01	0.060500	4.84e-01
Toll Like Receptor TLR1:TLR2 Cascade	92	3.16e-01	0.060500	4.84e-01
Toll Like Receptor TLR6:TLR2 Cascade	92	3.16e-01	0.060500	4.84e-01
RND2 GTPase cycle	40	5.08e-01	0.060400	6.71e-01
Transcriptional regulation by RUNX2	116	2.62e-01	0.060300	4.31e-01
Peroxisomal lipid metabolism	27	5.88e-01	0.060300	7.30e-01
Cell death signalling via NRAGE, NRIF and NADE	63	4.09e-01	0.060100	5.77e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	5.22e-01	-0.060000	6.81e-01
NRAGE signals death through JNK	47	4.77e-01	0.060000	6.38e-01
Signaling by FGFR	84	3.43e-01	0.059900	5.13e-01
Acetylcholine binding and downstream events	14	6.98e-01	0.059800	8.10e-01
Postsynaptic nicotinic acetylcholine receptors	14	6.98e-01	0.059800	8.10e-01
Fcgamma receptor (FCGR) dependent phagocytosis	81	3.52e-01	0.059800	5.20e-01
Signaling by FLT3 ITD and TKD mutants	16	6.79e-01	0.059800	7.98e-01
Post-translational protein modification	1243	4.50e-04	0.059300	2.91e-03
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	19	6.55e-01	-0.059200	7.78e-01
DAP12 interactions	40	5.18e-01	0.059100	6.78e-01
RND3 GTPase cycle	40	5.19e-01	0.058900	6.78e-01
RNA Polymerase II Transcription	1200	6.14e-04	0.058900	3.75e-03
Late endosomal microautophagy	29	5.85e-01	0.058600	7.28e-01
GAB1 signalosome	16	6.85e-01	-0.058600	8.01e-01
Formation of the beta-catenin:TCF transactivating complex	31	5.72e-01	0.058600	7.19e-01
Biotin transport and metabolism	10	7.48e-01	0.058500	8.41e-01
Cellular hexose transport	19	6.60e-01	0.058300	7.82e-01
Stimuli-sensing channels	86	3.50e-01	-0.058300	5.18e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	5.95e-01	0.058000	7.34e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	103	3.11e-01	-0.057800	4.83e-01
Synthesis, secretion, and deacylation of Ghrelin	19	6.63e-01	-0.057800	7.85e-01
PI-3K cascade:FGFR3	17	6.82e-01	-0.057400	7.98e-01
Striated Muscle Contraction	33	5.68e-01	-0.057400	7.18e-01
Interaction between L1 and Ankyrins	28	6.01e-01	-0.057100	7.38e-01
Regulation of Complement cascade	44	5.15e-01	-0.056700	6.76e-01
Expression and translocation of olfactory receptors	331	7.66e-02	0.056700	1.79e-01
Olfactory Signaling Pathway	338	7.45e-02	0.056500	1.75e-01
Extra-nuclear estrogen signaling	72	4.10e-01	-0.056100	5.77e-01
Integrin signaling	27	6.16e-01	0.055700	7.53e-01
Membrane Trafficking	563	2.52e-02	0.055200	7.65e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	7.63e-01	0.054900	8.55e-01
Amyloid fiber formation	53	4.92e-01	0.054600	6.52e-01
Transcriptional Regulation by VENTX	36	5.73e-01	0.054300	7.19e-01
ESR-mediated signaling	155	2.43e-01	0.054300	4.06e-01
Plasma lipoprotein clearance	36	5.73e-01	-0.054200	7.19e-01
Activation of BAD and translocation to mitochondria	15	7.17e-01	0.054000	8.24e-01
Pre-NOTCH Processing in Golgi	18	6.92e-01	-0.053900	8.05e-01
Surfactant metabolism	28	6.21e-01	0.053900	7.56e-01
Signaling by Rho GTPases	565	3.00e-02	0.053500	8.62e-02
Signaling by TGFB family members	114	3.24e-01	0.053400	4.94e-01
Glucocorticoid biosynthesis	10	7.71e-01	-0.053200	8.60e-01
MTOR signalling	35	5.86e-01	0.053200	7.29e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	13	7.40e-01	0.053200	8.36e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	5.77e-01	-0.053000	7.22e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	579	2.94e-02	0.053000	8.52e-02
Other semaphorin interactions	18	6.98e-01	0.052800	8.10e-01
Downstream signaling of activated FGFR2	29	6.23e-01	-0.052700	7.56e-01
PI3K/AKT Signaling in Cancer	101	3.60e-01	-0.052700	5.29e-01
Plasma lipoprotein assembly, remodeling, and clearance	72	4.44e-01	-0.052200	6.09e-01
Diseases associated with glycosylation precursor biosynthesis	15	7.27e-01	0.052100	8.29e-01
Signaling by KIT in disease	20	6.87e-01	0.052000	8.02e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	6.87e-01	0.052000	8.02e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	6.96e-01	-0.051700	8.09e-01
Metabolism of steroids	143	2.87e-01	0.051600	4.59e-01
Signaling by PDGFR in disease	20	6.94e-01	-0.050900	8.07e-01
Signaling by ERBB2 ECD mutants	15	7.33e-01	0.050800	8.32e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	6.30e-01	-0.050700	7.62e-01
Ketone body metabolism	10	7.83e-01	-0.050300	8.68e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	30	6.37e-01	0.049800	7.65e-01
G beta:gamma signalling through PI3Kgamma	25	6.68e-01	0.049600	7.88e-01
Plasma lipoprotein assembly	19	7.09e-01	0.049400	8.19e-01
Ca2+ pathway	58	5.16e-01	-0.049400	6.77e-01
Transcriptional regulation of white adipocyte differentiation	79	4.51e-01	0.049100	6.17e-01
Autophagy	112	3.74e-01	0.048700	5.41e-01
Signaling by EGFR	48	5.60e-01	0.048700	7.12e-01
Thromboxane signalling through TP receptor	24	6.81e-01	-0.048400	7.98e-01
FGFR1 mutant receptor activation	29	6.53e-01	-0.048200	7.77e-01
Iron uptake and transport	57	5.29e-01	0.048200	6.87e-01
Intracellular signaling by second messengers	302	1.51e-01	0.048000	2.89e-01
Signal Transduction	2325	1.67e-04	-0.047900	1.23e-03
Activation of HOX genes during differentiation	57	5.35e-01	0.047500	6.92e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	57	5.35e-01	0.047500	6.92e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	7.96e-01	-0.047100	8.76e-01
Vesicle-mediated transport	600	4.96e-02	0.047000	1.29e-01
Butyrophilin (BTN) family interactions	12	7.78e-01	-0.046900	8.67e-01
Mitochondrial Fatty Acid Beta-Oxidation	33	6.41e-01	0.046800	7.68e-01
NGF-stimulated transcription	39	6.16e-01	-0.046400	7.53e-01
RHO GTPases Activate ROCKs	19	7.30e-01	0.045700	8.30e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	12	7.85e-01	0.045400	8.69e-01
FGFR2b ligand binding and activation	10	8.04e-01	0.045300	8.80e-01
Branched-chain amino acid catabolism	20	7.26e-01	-0.045200	8.29e-01
Signalling to RAS	20	7.28e-01	0.045000	8.29e-01
Transport of vitamins, nucleosides, and related molecules	38	6.32e-01	-0.044800	7.63e-01
RHOF GTPase cycle	37	6.37e-01	0.044800	7.65e-01
Nucleotide salvage	21	7.22e-01	0.044800	8.27e-01
Metabolism of vitamins and cofactors	173	3.11e-01	0.044700	4.83e-01
Signal regulatory protein family interactions	13	7.81e-01	-0.044600	8.67e-01
Regulation of signaling by NODAL	11	7.98e-01	-0.044600	8.77e-01
Signaling by Receptor Tyrosine Kinases	485	9.42e-02	-0.044400	2.08e-01
Nuclear Events (kinase and transcription factor activation)	60	5.52e-01	0.044400	7.06e-01
Interleukin-37 signaling	19	7.39e-01	0.044100	8.36e-01
Downstream signal transduction	29	6.82e-01	0.044000	7.98e-01
Budding and maturation of HIV virion	25	7.04e-01	0.043900	8.15e-01
Miscellaneous transport and binding events	20	7.34e-01	-0.043900	8.33e-01
RHOD GTPase cycle	45	6.13e-01	0.043500	7.51e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	6.81e-01	-0.043300	7.98e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	7.87e-01	-0.043300	8.69e-01
Fertilization	22	7.26e-01	-0.043100	8.29e-01
p38MAPK events	13	7.88e-01	0.043100	8.69e-01
Processing and activation of SUMO	10	8.14e-01	-0.043000	8.87e-01
Signaling by FGFR1 in disease	36	6.56e-01	-0.042900	7.78e-01
TRP channels	24	7.17e-01	-0.042800	8.24e-01
Sensory processing of sound by outer hair cells of the cochlea	46	6.16e-01	-0.042700	7.53e-01
Formation of the cornified envelope	69	5.42e-01	0.042500	6.97e-01
Metabolism of water-soluble vitamins and cofactors	111	4.46e-01	0.041900	6.11e-01
Fatty acyl-CoA biosynthesis	31	6.88e-01	0.041700	8.02e-01
MAPK family signaling cascades	300	2.20e-01	0.041200	3.75e-01
Signaling by SCF-KIT	43	6.41e-01	0.041100	7.68e-01
Signaling by NTRK3 (TRKC)	16	7.76e-01	0.041000	8.65e-01
Ion channel transport	157	3.77e-01	-0.040900	5.44e-01
Signaling by NTRK2 (TRKB)	25	7.24e-01	-0.040800	8.28e-01
Signaling by Hedgehog	133	4.17e-01	0.040800	5.82e-01
Dectin-2 family	24	7.30e-01	-0.040700	8.30e-01
FOXO-mediated transcription of cell death genes	15	7.88e-01	0.040200	8.69e-01
Signaling by BRAF and RAF1 fusions	59	5.94e-01	0.040100	7.33e-01
RHO GTPase cycle	399	1.77e-01	0.039400	3.20e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	7.50e-01	-0.039200	8.42e-01
The canonical retinoid cycle in rods (twilight vision)	23	7.47e-01	-0.038900	8.41e-01
Lysosome Vesicle Biogenesis	33	6.99e-01	0.038900	8.10e-01
Metal ion SLC transporters	25	7.37e-01	-0.038800	8.34e-01
Retinoid metabolism and transport	41	6.67e-01	-0.038800	7.88e-01
Regulation of PTEN gene transcription	54	6.22e-01	0.038700	7.56e-01
Metabolism of fat-soluble vitamins	45	6.54e-01	-0.038600	7.77e-01
Signaling by FGFR1	49	6.41e-01	-0.038500	7.68e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	39	6.78e-01	0.038400	7.97e-01
Metabolism	1890	5.88e-03	0.038400	2.39e-02
Negative regulation of FGFR2 signaling	33	7.05e-01	-0.038100	8.15e-01
G alpha (12/13) signalling events	68	5.89e-01	0.037900	7.30e-01
Amino acid transport across the plasma membrane	30	7.20e-01	-0.037800	8.26e-01
LDL clearance	19	7.79e-01	-0.037200	8.67e-01
Recycling pathway of L1	22	7.67e-01	-0.036600	8.58e-01
RUNX3 regulates p14-ARF	10	8.42e-01	-0.036500	9.05e-01
Visual phototransduction	90	5.53e-01	-0.036200	7.07e-01
Sphingolipid metabolism	72	5.96e-01	0.036100	7.34e-01
Aspirin ADME	41	6.89e-01	-0.036100	8.03e-01
Sensory processing of sound by inner hair cells of the cochlea	61	6.26e-01	-0.036100	7.58e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	8.37e-01	0.035700	9.03e-01
MAPK1/MAPK3 signaling	263	3.19e-01	0.035700	4.88e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	8.18e-01	0.035500	8.90e-01
Signaling by VEGF	100	5.43e-01	-0.035200	6.99e-01
Signaling by NODAL	22	7.75e-01	-0.035100	8.65e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	7.86e-01	0.035100	8.69e-01
Signalling to ERKs	34	7.27e-01	0.034600	8.29e-01
Inactivation, recovery and regulation of the phototransduction cascade	29	7.48e-01	0.034400	8.41e-01
Generic Transcription Pathway	1097	5.52e-02	0.034400	1.39e-01
Cytochrome c-mediated apoptotic response	12	8.37e-01	0.034300	9.03e-01
Signaling by FGFR3	39	7.12e-01	0.034200	8.21e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	32	7.40e-01	0.033900	8.36e-01
Termination of O-glycan biosynthesis	22	7.83e-01	0.033900	8.68e-01
Response of Mtb to phagocytosis	22	7.84e-01	0.033700	8.68e-01
Keratinization	201	4.10e-01	0.033700	5.77e-01
Organic cation transport	10	8.54e-01	0.033700	9.14e-01
Vitamin D (calciferol) metabolism	12	8.41e-01	0.033500	9.05e-01
Downstream signaling of activated FGFR4	26	7.67e-01	-0.033500	8.58e-01
Bile acid and bile salt metabolism	43	7.06e-01	-0.033300	8.16e-01
Sialic acid metabolism	33	7.41e-01	-0.033200	8.36e-01
Fatty acids	15	8.24e-01	-0.033200	8.94e-01
Signaling by NTRK1 (TRKA)	114	5.41e-01	0.033200	6.97e-01
RAB geranylgeranylation	54	6.84e-01	-0.032000	8.01e-01
Other interleukin signaling	22	7.96e-01	-0.031900	8.76e-01
Heme signaling	44	7.15e-01	-0.031800	8.23e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	117	5.55e-01	0.031600	7.09e-01
Smooth Muscle Contraction	39	7.35e-01	-0.031400	8.33e-01
Pre-NOTCH Expression and Processing	55	6.88e-01	0.031300	8.02e-01
Negative regulation of MET activity	20	8.10e-01	-0.031100	8.85e-01
Nephrin family interactions	21	8.07e-01	-0.030800	8.83e-01
The NLRP3 inflammasome	16	8.33e-01	0.030500	9.00e-01
Apoptotic factor-mediated response	17	8.28e-01	0.030400	8.98e-01
Signaling by NOTCH3	47	7.19e-01	0.030400	8.25e-01
RAF/MAP kinase cascade	257	4.02e-01	0.030400	5.70e-01
Signaling by NOTCH1	69	6.65e-01	0.030200	7.87e-01
Prolonged ERK activation events	14	8.46e-01	-0.030000	9.09e-01
VEGFA-VEGFR2 Pathway	92	6.20e-01	-0.029900	7.55e-01
Post-translational modification: synthesis of GPI-anchored proteins	86	6.33e-01	0.029800	7.63e-01
Metabolism of folate and pterines	16	8.36e-01	-0.029800	9.03e-01
EGFR downregulation	29	7.82e-01	-0.029700	8.68e-01
Factors involved in megakaryocyte development and platelet production	120	5.81e-01	0.029200	7.25e-01
Signaling by PDGF	51	7.21e-01	-0.028900	8.26e-01
Role of phospholipids in phagocytosis	23	8.12e-01	0.028600	8.86e-01
Effects of PIP2 hydrolysis	26	8.01e-01	-0.028600	8.79e-01
Constitutive Signaling by Overexpressed ERBB2	10	8.77e-01	0.028200	9.29e-01
Plasma lipoprotein remodeling	32	7.83e-01	-0.028200	8.68e-01
Glycogen metabolism	24	8.11e-01	0.028200	8.86e-01
RHOA GTPase cycle	128	5.84e-01	0.028100	7.28e-01
Gap junction trafficking	27	8.01e-01	0.028000	8.79e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	8.56e-01	0.028000	9.14e-01
Signaling by FGFR2 in disease	42	7.55e-01	0.027800	8.47e-01
Deactivation of the beta-catenin transactivating complex	38	7.67e-01	-0.027800	8.58e-01
Signaling by FGFR4	40	7.62e-01	0.027700	8.54e-01
Developmental Biology	991	1.45e-01	-0.027400	2.82e-01
Neutrophil degranulation	443	3.24e-01	-0.027400	4.93e-01
FOXO-mediated transcription of cell cycle genes	16	8.50e-01	0.027300	9.12e-01
Caspase-mediated cleavage of cytoskeletal proteins	11	8.77e-01	-0.027000	9.29e-01
Activation of gene expression by SREBF (SREBP)	40	7.71e-01	0.026600	8.60e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	8.64e-01	-0.026500	9.19e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	8.19e-01	-0.026500	8.90e-01
Synthesis of PIPs at the Golgi membrane	17	8.50e-01	-0.026400	9.12e-01
Pexophagy	11	8.81e-01	0.026000	9.32e-01
Signaling by NOTCH2	31	8.04e-01	0.025800	8.80e-01
Nucleotide catabolism	32	8.03e-01	-0.025500	8.80e-01
Signaling by FGFR in disease	60	7.33e-01	0.025500	8.32e-01
G-protein beta:gamma signalling	30	8.15e-01	0.024700	8.88e-01
Depolymerisation of the Nuclear Lamina	12	8.83e-01	0.024500	9.34e-01
Oncogenic MAPK signaling	75	7.14e-01	0.024400	8.23e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	28	8.24e-01	-0.024300	8.94e-01
Interconversion of nucleotide di- and triphosphates	24	8.38e-01	0.024100	9.03e-01
mRNA Editing	10	8.96e-01	0.023900	9.41e-01
Semaphorin interactions	60	7.49e-01	-0.023900	8.41e-01
Axon guidance	497	3.69e-01	0.023500	5.37e-01
Ovarian tumor domain proteases	36	8.08e-01	0.023400	8.84e-01
Glyoxylate metabolism and glycine degradation	29	8.30e-01	0.023000	8.99e-01
Nervous system development	519	3.76e-01	0.022700	5.43e-01
Transport of small molecules	668	3.22e-01	-0.022500	4.92e-01
G beta:gamma signalling through PLC beta	20	8.63e-01	-0.022300	9.19e-01
Energy dependent regulation of mTOR by LKB1-AMPK	23	8.53e-01	-0.022300	9.14e-01
SUMOylation of transcription cofactors	43	8.01e-01	0.022200	8.79e-01
Synthesis of PIPs at the late endosome membrane	10	9.04e-01	0.022000	9.46e-01
Cell surface interactions at the vascular wall	128	6.69e-01	-0.021900	7.88e-01
Signaling by Nuclear Receptors	231	5.71e-01	-0.021600	7.19e-01
PI Metabolism	79	7.42e-01	0.021400	8.36e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	8.99e-01	0.021300	9.42e-01
Signal attenuation	10	9.07e-01	0.021200	9.47e-01
Binding and Uptake of Ligands by Scavenger Receptors	40	8.18e-01	-0.021000	8.90e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	24	8.59e-01	-0.021000	9.16e-01
Laminin interactions	23	8.63e-01	-0.020700	9.19e-01
TCF dependent signaling in response to WNT	167	6.50e-01	0.020400	7.75e-01
RHOG GTPase cycle	64	7.79e-01	0.020200	8.67e-01
Mismatch Repair	15	8.92e-01	0.020200	9.39e-01
Negative regulation of FGFR4 signaling	30	8.49e-01	-0.020000	9.12e-01
Synthesis of PIPs at the early endosome membrane	15	8.94e-01	-0.019800	9.40e-01
Synthesis of substrates in N-glycan biosythesis	59	7.95e-01	0.019600	8.76e-01
Diseases of carbohydrate metabolism	30	8.53e-01	0.019500	9.14e-01
Amino acids regulate mTORC1	44	8.30e-01	0.018700	8.99e-01
Phase II - Conjugation of compounds	105	7.41e-01	-0.018700	8.36e-01
Signaling by NTRKs	132	7.29e-01	0.017500	8.29e-01
MET promotes cell motility	29	8.74e-01	-0.017000	9.27e-01
Downstream signaling of activated FGFR3	24	8.86e-01	-0.016900	9.35e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	9.27e-01	0.016700	9.60e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	9.09e-01	0.016500	9.47e-01
p75NTR recruits signalling complexes	12	9.22e-01	-0.016300	9.57e-01
Signaling by EGFR in Cancer	24	8.90e-01	0.016200	9.38e-01
Interleukin-10 signaling	43	8.55e-01	-0.016100	9.14e-01
mTORC1-mediated signalling	18	9.06e-01	0.016100	9.47e-01
Prolactin receptor signaling	15	9.14e-01	-0.016100	9.51e-01
Activation of kainate receptors upon glutamate binding	29	8.86e-01	-0.015400	9.35e-01
Transferrin endocytosis and recycling	30	8.88e-01	-0.014900	9.36e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	8.56e-01	-0.014900	9.14e-01
Sensory Perception	534	5.68e-01	0.014500	7.18e-01
Signaling by MET	66	8.40e-01	0.014400	9.05e-01
Signaling by FLT3 fusion proteins	19	9.14e-01	0.014300	9.51e-01
Chylomicron remodeling	10	9.38e-01	-0.014300	9.68e-01
The phototransduction cascade	30	8.99e-01	0.013400	9.42e-01
Metabolism of steroid hormones	33	8.97e-01	0.013100	9.41e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	9.33e-01	0.012900	9.64e-01
RHO GTPases activate PAKs	19	9.24e-01	0.012700	9.58e-01
Glutathione conjugation	37	8.94e-01	-0.012700	9.40e-01
Antimicrobial peptides	70	8.55e-01	0.012600	9.14e-01
FOXO-mediated transcription	64	8.65e-01	-0.012300	9.19e-01
Diseases associated with the TLR signaling cascade	29	9.09e-01	-0.012200	9.47e-01
Diseases of Immune System	29	9.09e-01	-0.012200	9.47e-01
Metabolism of carbohydrates	266	7.37e-01	-0.012000	8.34e-01
Synthesis of bile acids and bile salts	34	9.08e-01	0.011400	9.47e-01
Complement cascade	55	8.90e-01	-0.010800	9.38e-01
RAC2 GTPase cycle	74	8.74e-01	-0.010700	9.27e-01
Clathrin-mediated endocytosis	134	8.32e-01	-0.010600	9.00e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	12	9.51e-01	-0.010300	9.78e-01
Metabolism of porphyrins	27	9.27e-01	-0.010200	9.60e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	9.47e-01	0.010200	9.76e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	9.47e-01	0.010200	9.76e-01
RAC3 GTPase cycle	78	8.81e-01	-0.009770	9.32e-01
Glycerophospholipid biosynthesis	111	8.62e-01	-0.009580	9.18e-01
Hyaluronan metabolism	15	9.49e-01	-0.009500	9.77e-01
Synthesis of PC	27	9.32e-01	0.009480	9.64e-01
RHOB GTPase cycle	60	9.01e-01	-0.009250	9.44e-01
Infection with Mycobacterium tuberculosis	26	9.35e-01	-0.009250	9.65e-01
MET receptor recycling	10	9.65e-01	-0.008060	9.87e-01
Synthesis of PIPs at the plasma membrane	48	9.28e-01	0.007590	9.60e-01
VxPx cargo-targeting to cilium	20	9.57e-01	0.006890	9.83e-01
Hormone ligand-binding receptors	13	9.66e-01	-0.006880	9.87e-01
ATF6 (ATF6-alpha) activates chaperones	11	9.69e-01	0.006790	9.88e-01
Activation of BH3-only proteins	30	9.50e-01	-0.006670	9.77e-01
SLC transporter disorders	91	9.15e-01	-0.006460	9.51e-01
Rab regulation of trafficking	103	9.12e-01	0.006300	9.49e-01
Formation of apoptosome	10	9.74e-01	0.006000	9.89e-01
Regulation of the apoptosome activity	10	9.74e-01	0.006000	9.89e-01
Cargo recognition for clathrin-mediated endocytosis	97	9.21e-01	-0.005800	9.57e-01
Signaling by WNT	257	8.74e-01	-0.005740	9.27e-01
Insulin receptor recycling	25	9.61e-01	0.005670	9.85e-01
FGFR2 mutant receptor activation	32	9.56e-01	0.005640	9.82e-01
RAC1 GTPase cycle	159	9.03e-01	-0.005610	9.45e-01
G beta:gamma signalling through CDC42	19	9.66e-01	0.005570	9.87e-01
Metabolism of lipids	669	8.22e-01	0.005110	8.93e-01
Negative regulation of FGFR3 signaling	28	9.65e-01	-0.004830	9.87e-01
DARPP-32 events	24	9.68e-01	0.004690	9.88e-01
G beta:gamma signalling through BTK	17	9.74e-01	0.004630	9.89e-01
Sema4D induced cell migration and growth-cone collapse	20	9.72e-01	0.004470	9.89e-01
Heme degradation	16	9.75e-01	-0.004460	9.89e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	21	9.74e-01	-0.004090	9.89e-01
Ion transport by P-type ATPases	50	9.60e-01	-0.004090	9.85e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	9.77e-01	-0.004000	9.89e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	9.77e-01	-0.004000	9.89e-01
Gap junction trafficking and regulation	29	9.70e-01	-0.003980	9.89e-01
EPHA-mediated growth cone collapse	15	9.79e-01	-0.003900	9.90e-01
Sema4D in semaphorin signaling	23	9.75e-01	-0.003810	9.89e-01
Listeria monocytogenes entry into host cells	19	9.78e-01	0.003700	9.89e-01
Pyruvate metabolism	27	9.74e-01	-0.003690	9.89e-01
Glycogen storage diseases	14	9.83e-01	-0.003220	9.92e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	9.88e-01	0.002840	9.95e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	9.81e-01	0.002700	9.92e-01
EPH-Ephrin signaling	89	9.66e-01	-0.002620	9.87e-01
PKMTs methylate histone lysines	32	9.83e-01	0.002220	9.92e-01
NRIF signals cell death from the nucleus	16	9.89e-01	0.002000	9.95e-01
Phospholipid metabolism	189	9.66e-01	0.001820	9.87e-01
NR1H2 and NR1H3-mediated signaling	49	9.84e-01	-0.001690	9.92e-01
Reactions specific to the complex N-glycan synthesis pathway	10	9.93e-01	0.001510	9.99e-01
Glycosphingolipid metabolism	39	9.87e-01	-0.001480	9.95e-01
CDC42 GTPase cycle	132	9.88e-01	0.000744	9.95e-01
Membrane binding and targetting of GAG proteins	12	9.97e-01	0.000714	9.99e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	9.97e-01	0.000714	9.99e-01
Presynaptic function of Kainate receptors	21	9.96e-01	0.000633	9.99e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	25	9.96e-01	-0.000604	9.99e-01
p130Cas linkage to MAPK signaling for integrins	15	9.98e-01	0.000435	9.99e-01
Acyl chain remodelling of PC	25	9.99e-01	-0.000173	9.99e-01
Signaling by PDGFRA extracellular domain mutants	12	9.99e-01	0.000108	9.99e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	9.99e-01	0.000108	9.99e-01

---

Detailed Gene set reports

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

	797
set	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
setSize	10
pANOVA	0.000121
s.dist	-0.702
p.adjustANOVA	0.000928

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2A	-10144.5
TFAP2B	-9849.5
WWOX	-9549.5
TFAP2D	-9220.5
KCTD1	-8979.5
TFAP2E	-8888.5
TFAP2C	-8702.5
SUMO1	-6209.5
KCTD15	-4663.5
UBE2I	3112.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2A	-10144.5
TFAP2B	-9849.5
WWOX	-9549.5
TFAP2D	-9220.5
KCTD1	-8979.5
TFAP2E	-8888.5
TFAP2C	-8702.5
SUMO1	-6209.5
KCTD15	-4663.5
UBE2I	3112.5

---

Regulation of commissural axon pathfinding by SLIT and ROBO

Regulation of commissural axon pathfinding by SLIT and ROBO

	1099
set	Regulation of commissural axon pathfinding by SLIT and ROBO
setSize	10
pANOVA	0.000391
s.dist	-0.647
p.adjustANOVA	0.00257

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ROBO1	-9926.5
ROBO3	-9689.5
SLIT2	-9341.5
DCC	-8882.5
SLIT1	-8867.5
ROBO2	-8190.5
NTN1	-7122.5
SLIT3	-4049.5
SRC	-2719.5
NELL2	1155.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ROBO1	-9926.5
ROBO3	-9689.5
SLIT2	-9341.5
DCC	-8882.5
SLIT1	-8867.5
ROBO2	-8190.5
NTN1	-7122.5
SLIT3	-4049.5
SRC	-2719.5
NELL2	1155.5

---

Apoptotic cleavage of cell adhesion proteins

Apoptotic cleavage of cell adhesion proteins

	87
set	Apoptotic cleavage of cell adhesion proteins
setSize	11
pANOVA	0.00021
s.dist	-0.645
p.adjustANOVA	0.0015

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDH1	-10015.5
DSG2	-8892.5
OCLN	-8765.5
DSP	-8238.5
PKP1	-7981.5
DSG1	-7646.5
DSG3	-7139.5
TJP1	-6555.5
CTNNB1	-5972.5
CASP3	-1851.5
TJP2	-1101.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDH1	-10015.5
DSG2	-8892.5
OCLN	-8765.5
DSP	-8238.5
PKP1	-7981.5
DSG1	-7646.5
DSG3	-7139.5
TJP1	-6555.5
CTNNB1	-5972.5
CASP3	-1851.5
TJP2	-1101.5

---

Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation

	1418
set	Transcriptional regulation of testis differentiation
setSize	12
pANOVA	0.000235
s.dist	-0.613
p.adjustANOVA	0.00165

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WT1	-10298.5
GATA4	-10244.5
FOXL2	-10176.5
ZFPM2	-8732.5
DMRT1	-8362.5
DHH	-7436.5
SOX9	-7376.5
WNT4	-6085.5
FGF9	-3077.5
AMH	-2959.5
NR5A1	-2262.5
PTGDS	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WT1	-10298.5
GATA4	-10244.5
FOXL2	-10176.5
ZFPM2	-8732.5
DMRT1	-8362.5
DHH	-7436.5
SOX9	-7376.5
WNT4	-6085.5
FGF9	-3077.5
AMH	-2959.5
NR5A1	-2262.5
PTGDS	0.5

---

Thyroxine biosynthesis

Thyroxine biosynthesis

	1386
set	Thyroxine biosynthesis
setSize	10
pANOVA	0.00342
s.dist	-0.534
p.adjustANOVA	0.0159

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUOX1	-10092.5
DUOX2	-9514.5
DIO3	-9503.5
SLC5A5	-7015.5
TPO	-6460.5
IYD	-4442.5
CGA	-3974.5
DIO1	-3896.5
DIO2	-1381.5
TSHB	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUOX1	-10092.5
DUOX2	-9514.5
DIO3	-9503.5
SLC5A5	-7015.5
TPO	-6460.5
IYD	-4442.5
CGA	-3974.5
DIO1	-3896.5
DIO2	-1381.5
TSHB	0.5

---

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

	879
set	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
setSize	10
pANOVA	0.00558
s.dist	-0.506
p.adjustANOVA	0.0229

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SOX2	-10263.5
GSC	-10210.5
CDX2	-10119.5
HHEX	-9896.5
DKK1	-7767.5
TSC22D1	-3505.5
EOMES	-2702.5
POU5F1	-1517.5
NANOG	0.5
GATA6	2549.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SOX2	-10263.5
GSC	-10210.5
CDX2	-10119.5
HHEX	-9896.5
DKK1	-7767.5
TSC22D1	-3505.5
EOMES	-2702.5
POU5F1	-1517.5
NANOG	0.5
GATA6	2549.5

---

ERBB2 Activates PTK6 Signaling

ERBB2 Activates PTK6 Signaling

	367
set	ERBB2 Activates PTK6 Signaling
setSize	13
pANOVA	0.00183
s.dist	-0.499
p.adjustANOVA	0.00925

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EREG	-9073.5
HBEGF	-8952.5
NRG1	-8678.5
ERBB4	-5776.5
EGFR	-5339.5
ERBB2	-5277.5
NRG3	-4974.5
NRG4	-4932.5
PTK6	-4789.5
EGF	-4659.5
BTC	-3088.5
ERBB3	-1855.5
NRG2	-1145.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EREG	-9073.5
HBEGF	-8952.5
NRG1	-8678.5
ERBB4	-5776.5
EGFR	-5339.5
ERBB2	-5277.5
NRG3	-4974.5
NRG4	-4932.5
PTK6	-4789.5
EGF	-4659.5
BTC	-3088.5
ERBB3	-1855.5
NRG2	-1145.5

---

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

	796
set	Negative regulation of TCF-dependent signaling by WNT ligand antagonists
setSize	15
pANOVA	0.000955
s.dist	-0.493
p.adjustANOVA	0.0054

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SFRP2	-10299.5
LRP6	-9973.5
WNT3A	-9927.5
DKK2	-9836.5
DKK4	-9429.5
WNT5A	-8680.5
DKK1	-7767.5
SFRP1	-6574.5
WNT4	-6085.5
KREMEN1	-4443.5
SOST	-3199.5
LRP5	-2430.5
KREMEN2	2227.5
WIF1	3356.5
WNT9A	4966.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SFRP2	-10299.5
LRP6	-9973.5
WNT3A	-9927.5
DKK2	-9836.5
DKK4	-9429.5
WNT5A	-8680.5
DKK1	-7767.5
SFRP1	-6574.5
WNT4	-6085.5
KREMEN1	-4443.5
SOST	-3199.5
LRP5	-2430.5
KREMEN2	2227.5
WIF1	3356.5
WNT9A	4966.5

---

Adenylate cyclase activating pathway

Adenylate cyclase activating pathway

	64
set	Adenylate cyclase activating pathway
setSize	10
pANOVA	0.00813
s.dist	-0.483
p.adjustANOVA	0.0313

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY9	-9666.5
ADCY8	-9621.5
ADCY7	-9583.5
ADCY4	-7351.5
GNAL	-6403.5
ADCY6	-5223.5
ADCY1	-4967.5
ADCY2	-4301.5
ADCY5	939.5
ADCY3	5031.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY9	-9666.5
ADCY8	-9621.5
ADCY7	-9583.5
ADCY4	-7351.5
GNAL	-6403.5
ADCY6	-5223.5
ADCY1	-4967.5
ADCY2	-4301.5
ADCY5	939.5
ADCY3	5031.5

---

Acetylcholine Neurotransmitter Release Cycle

Acetylcholine Neurotransmitter Release Cycle

	29
set	Acetylcholine Neurotransmitter Release Cycle
setSize	16
pANOVA	0.000928
s.dist	-0.478
p.adjustANOVA	0.00526

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC5A7	-10211.5
SLC18A3	-10184.5
CHAT	-10063.5
SNAP25	-9847.5
RIMS1	-9673.5
PPFIA2	-9579.5
RAB3A	-8759.5
CPLX1	-7172.5
STX1A	-6127.5
PPFIA3	-5718.5
SYT1	-4800.5
PPFIA1	-2284.5
UNC13B	0.5
STXBP1	1518.5
VAMP2	3660.5
PPFIA4	8268.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC5A7	-10211.5
SLC18A3	-10184.5
CHAT	-10063.5
SNAP25	-9847.5
RIMS1	-9673.5
PPFIA2	-9579.5
RAB3A	-8759.5
CPLX1	-7172.5
STX1A	-6127.5
PPFIA3	-5718.5
SYT1	-4800.5
PPFIA1	-2284.5
UNC13B	0.5
STXBP1	1518.5
VAMP2	3660.5
PPFIA4	8268.5

---

GABA synthesis, release, reuptake and degradation

GABA synthesis, release, reuptake and degradation

	479
set	GABA synthesis, release, reuptake and degradation
setSize	19
pANOVA	0.000344
s.dist	-0.474
p.adjustANOVA	0.00229

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC6A11	-9994.5
SNAP25	-9847.5
GAD1	-9813.5
RIMS1	-9673.5
SLC32A1	-9476.5
RAB3A	-8759.5
SLC6A1	-8429.5
DNAJC5	-7378.5
CPLX1	-7172.5
STX1A	-6127.5
SLC6A12	-5823.5
SLC6A13	-5163.5
SYT1	-4800.5
ABAT	-4399.5
GAD2	-4227.5
STXBP1	1518.5
VAMP2	3660.5
ALDH5A1	4643.5
HSPA8	5840.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC6A11	-9994.5
SNAP25	-9847.5
GAD1	-9813.5
RIMS1	-9673.5
SLC32A1	-9476.5
RAB3A	-8759.5
SLC6A1	-8429.5
DNAJC5	-7378.5
CPLX1	-7172.5
STX1A	-6127.5
SLC6A12	-5823.5
SLC6A13	-5163.5
SYT1	-4800.5
ABAT	-4399.5
GAD2	-4227.5
STXBP1	1518.5
VAMP2	3660.5
ALDH5A1	4643.5
HSPA8	5840.5

---

Platelet sensitization by LDL

Platelet sensitization by LDL

	923
set	Platelet sensitization by LDL
setSize	17
pANOVA	0.000819
s.dist	0.469
p.adjustANOVA	0.00477

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PECAM1	9257.5
PPP2R1A	9104.5
PTPN6	9094.5
APOB	7927.5
PPP2R1B	7867.5
PLA2G4A	7317.5
PTPN11	7001.5
PPP2R5C	6973.5
PPP2CA	6873.5
LRP8	6592.5
PPP2R5A	4278.5
PPP2R5B	2990.5
PPP2CB	2373.5
PPP2R5E	1228.5
MAPK14	1094.5
PPP2R5D	-4562.5
FGR	-9891.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PECAM1	9257.5
PPP2R1A	9104.5
PTPN6	9094.5
APOB	7927.5
PPP2R1B	7867.5
PLA2G4A	7317.5
PTPN11	7001.5
PPP2R5C	6973.5
PPP2CA	6873.5
LRP8	6592.5
PPP2R5A	4278.5
PPP2R5B	2990.5
PPP2CB	2373.5
PPP2R5E	1228.5
MAPK14	1094.5
PPP2R5D	-4562.5
FGR	-9891.5

---

Defective B3GALTL causes PpS

Defective B3GALTL causes PpS

	275
set	Defective B3GALTL causes PpS
setSize	34
pANOVA	2.91e-06
s.dist	-0.463
p.adjustANOVA	5.21e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPON2	-10282.5
ADAMTS5	-10131.5
ADAMTS19	-9967.5
ADAMTS18	-9931.5
SPON1	-9784.5
ADAMTS14	-9513.5
SEMA5A	-9365.5
THBS2	-9133.5
ADAMTS20	-8211.5
ADAMTS4	-8118.5
ADAMTS1	-8044.5
ADAMTSL1	-7705.5
ADAMTS10	-7404.5
ADAMTSL5	-7166.5
SEMA5B	-7093.5
ADAMTS17	-6775.5
ADAMTS16	-6404.5
ADAMTS9	-6281.5
ADAMTS3	-5406.5
ADAMTS8	-4046.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPON2	-10282.5
ADAMTS5	-10131.5
ADAMTS19	-9967.5
ADAMTS18	-9931.5
SPON1	-9784.5
ADAMTS14	-9513.5
SEMA5A	-9365.5
THBS2	-9133.5
ADAMTS20	-8211.5
ADAMTS4	-8118.5
ADAMTS1	-8044.5
ADAMTSL1	-7705.5
ADAMTS10	-7404.5
ADAMTSL5	-7166.5
SEMA5B	-7093.5
ADAMTS17	-6775.5
ADAMTS16	-6404.5
ADAMTS9	-6281.5
ADAMTS3	-5406.5
ADAMTS8	-4046.5
THSD4	-3472.5
THSD1	-2886.5
THSD7A	-2602.5
ADAMTS2	-2231.5
ADAMTSL3	-1898.5
ADAMTS13	-1745.5
ADAMTS12	-1503.5
ADAMTSL4	-1466.5
ADAMTSL2	-1264.5
THBS1	-1137.5
ADAMTS15	2165.5
ADAMTS7	2509.5
ADAMTS6	4641.5
THSD7B	4769.5

---

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

	1360
set	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
setSize	19
pANOVA	0.000492
s.dist	0.462
p.adjustANOVA	0.00313

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PLK3	9734.5
BTG2	8636.5
NPM1	7401.5
CENPJ	7240.5
CNOT2	7035.5
CNOT6L	6690.5
TP53	6572.5
CNOT10	6342.5
CNOT4	6331.5
CNOT3	6292.5
RQCD1	5945.5
CNOT7	5363.5
CNOT8	4450.5
PLK2	4427.5
CNOT6	4411.5
TNKS1BP1	0.5
CNOT1	-2618.5
CDC25C	-3732.5
PLAGL1	-7458.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PLK3	9734.5
BTG2	8636.5
NPM1	7401.5
CENPJ	7240.5
CNOT2	7035.5
CNOT6L	6690.5
TP53	6572.5
CNOT10	6342.5
CNOT4	6331.5
CNOT3	6292.5
RQCD1	5945.5
CNOT7	5363.5
CNOT8	4450.5
PLK2	4427.5
CNOT6	4411.5
TNKS1BP1	0.5
CNOT1	-2618.5
CDC25C	-3732.5
PLAGL1	-7458.5

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1167
set	SRP-dependent cotranslational protein targeting to membrane
setSize	105
pANOVA	1.16e-15
s.dist	0.452
p.adjustANOVA	3.53e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
SPCS1	9498.5
SRP68	9497.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
SPCS3	8799.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
SEC11A	8228.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
SPCS1	9498.5
SRP68	9497.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
SPCS3	8799.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
SEC11A	8228.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
RPL7	7560.5
RPL23	7452.5
SSR3	7273.5
FAU	7219.5
DDOST	6940.5
RPSA	6921.5
SEC61A1	6769.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
SRPRB	6186.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
RPN2	5938.5
SRP54	5702.5
SEC11C	5659.5
RPL30	5424.5
SRP19	5330.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
UBA52	4851.5
RPL35A	4742.5
SEC61B	4741.0
RPL11	4727.5
RPS26	4696.5
RPL28	4530.5
SRP72	4255.5
RPS25	4215.5
TRAM1	4211.5
RPL15	4146.5
RPL17	3881.5
RPN1	3805.5
RPL27A	3799.5
SEC61G	3781.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
SSR1	3324.5
RPS7	3074.5
SRP14	2999.5
SRP9	2959.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
RPS9	2072.5
RPS16	1569.5
SSR2	1443.5
RPL31	1252.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
SPCS2	-2590.5
RPS3	-2710.5
RPL37	-2940.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
RPL22L1	-3698.5
RPL27	-4466.5
RPL26L1	-6272.5
SEC61A2	-6610.5
RPLP1	-7811.5

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	1162
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.00945
s.dist	0.452
p.adjustANOVA	0.0354

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLBP	9026.5
SNRPD3	8336.5
ZNF473	8159.5
NCBP1	6996.5
SNRPG	6730.5
NCBP2	5887.5
SNRPE	3944.5
SNRPF	2498.5
SNRPB	2362.5
LSM11	-1511.5
LSM10	-5407.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLBP	9026.5
SNRPD3	8336.5
ZNF473	8159.5
NCBP1	6996.5
SNRPG	6730.5
NCBP2	5887.5
SNRPE	3944.5
SNRPF	2498.5
SNRPB	2362.5
LSM11	-1511.5
LSM10	-5407.5

---

TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

	1340
set	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
setSize	12
pANOVA	0.0075
s.dist	-0.446
p.adjustANOVA	0.0295

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2A	-10144.5
ESR1	-9959.5
TFAP2B	-9849.5
TFAP2C	-8702.5
VEGFA	-5826.5
KIT	-5667.5
EGFR	-5339.5
ERBB2	-5277.5
CGA	-3974.5
YY1	0.5
TGFA	899.5
ATAD2	6998.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2A	-10144.5
ESR1	-9959.5
TFAP2B	-9849.5
TFAP2C	-8702.5
VEGFA	-5826.5
KIT	-5667.5
EGFR	-5339.5
ERBB2	-5277.5
CGA	-3974.5
YY1	0.5
TGFA	899.5
ATAD2	6998.5

---

O-glycosylation of TSR domain-containing proteins

O-glycosylation of TSR domain-containing proteins

	837
set	O-glycosylation of TSR domain-containing proteins
setSize	35
pANOVA	5.09e-06
s.dist	-0.445
p.adjustANOVA	8.03e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPON2	-10282.5
ADAMTS5	-10131.5
ADAMTS19	-9967.5
ADAMTS18	-9931.5
SPON1	-9784.5
ADAMTS14	-9513.5
SEMA5A	-9365.5
THBS2	-9133.5
ADAMTS20	-8211.5
ADAMTS4	-8118.5
ADAMTS1	-8044.5
ADAMTSL1	-7705.5
ADAMTS10	-7404.5
ADAMTSL5	-7166.5
SEMA5B	-7093.5
ADAMTS17	-6775.5
ADAMTS16	-6404.5
ADAMTS9	-6281.5
ADAMTS3	-5406.5
ADAMTS8	-4046.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPON2	-10282.5
ADAMTS5	-10131.5
ADAMTS19	-9967.5
ADAMTS18	-9931.5
SPON1	-9784.5
ADAMTS14	-9513.5
SEMA5A	-9365.5
THBS2	-9133.5
ADAMTS20	-8211.5
ADAMTS4	-8118.5
ADAMTS1	-8044.5
ADAMTSL1	-7705.5
ADAMTS10	-7404.5
ADAMTSL5	-7166.5
SEMA5B	-7093.5
ADAMTS17	-6775.5
ADAMTS16	-6404.5
ADAMTS9	-6281.5
ADAMTS3	-5406.5
ADAMTS8	-4046.5
THSD4	-3472.5
THSD1	-2886.5
THSD7A	-2602.5
ADAMTS2	-2231.5
ADAMTSL3	-1898.5
ADAMTS13	-1745.5
ADAMTS12	-1503.5
ADAMTSL4	-1466.5
ADAMTSL2	-1264.5
THBS1	-1137.5
POFUT2	1392.5
ADAMTS15	2165.5
ADAMTS7	2509.5
ADAMTS6	4641.5
THSD7B	4769.5

---

Carnitine metabolism

Carnitine metabolism

	168
set	Carnitine metabolism
setSize	11
pANOVA	0.0106
s.dist	-0.445
p.adjustANOVA	0.0389

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CPT2	-9512.5
PRKAA2	-9419.5
RXRA	-9009.5
CPT1A	-8944.5
CPT1B	-8013.5
PRKAG2	-5376.5
THRSP	-4045.5
PPARD	-3231.5
SLC22A5	932.5
SLC25A20	1856.5
PRKAB2	2751.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CPT2	-9512.5
PRKAA2	-9419.5
RXRA	-9009.5
CPT1A	-8944.5
CPT1B	-8013.5
PRKAG2	-5376.5
THRSP	-4045.5
PPARD	-3231.5
SLC22A5	932.5
SLC25A20	1856.5
PRKAB2	2751.5

---

Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen

	385
set	Erythrocytes take up carbon dioxide and release oxygen
setSize	12
pANOVA	0.00792
s.dist	-0.443
p.adjustANOVA	0.0306

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HBA1	-9280.5
RHAG	-7409.5
HBB	-7181.5
SLC4A1	-6845.5
CA4	-6032.5
CYB5R1	-5234.5
CA2	-3135.5
CA1	-2606.5
AQP1	-2543.5
CYB5RL	-2449.5
CYB5R2	-2214.5
CYB5R4	-1541.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HBA1	-9280.5
RHAG	-7409.5
HBB	-7181.5
SLC4A1	-6845.5
CA4	-6032.5
CYB5R1	-5234.5
CA2	-3135.5
CA1	-2606.5
AQP1	-2543.5
CYB5RL	-2449.5
CYB5R2	-2214.5
CYB5R4	-1541.5

---

O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes

	840
set	O2/CO2 exchange in erythrocytes
setSize	12
pANOVA	0.00792
s.dist	-0.443
p.adjustANOVA	0.0306

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HBA1	-9280.5
RHAG	-7409.5
HBB	-7181.5
SLC4A1	-6845.5
CA4	-6032.5
CYB5R1	-5234.5
CA2	-3135.5
CA1	-2606.5
AQP1	-2543.5
CYB5RL	-2449.5
CYB5R2	-2214.5
CYB5R4	-1541.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HBA1	-9280.5
RHAG	-7409.5
HBB	-7181.5
SLC4A1	-6845.5
CA4	-6032.5
CYB5R1	-5234.5
CA2	-3135.5
CA1	-2606.5
AQP1	-2543.5
CYB5RL	-2449.5
CYB5R2	-2214.5
CYB5R4	-1541.5

---

PD-1 signaling

PD-1 signaling

	857
set	PD-1 signaling
setSize	21
pANOVA	0.000447
s.dist	0.442
p.adjustANOVA	0.0029

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD3D	9774.5
LCK	9746.5
CD3G	9724.5
CD3E	9685.5
HLA-DRB1	9265.5
PTPN6	9094.5
PDCD1	8650.5
CD274	8231.5
HLA-DRA	8025.5
CSK	7828.5
HLA-DQB1	7351.5
PTPN11	7001.5
CD4	6152.5
CD247	5800.5
HLA-DRB5	0.5
PDCD1LG2	-905.5
HLA-DPA1	-1907.5
HLA-DQB2	-2780.5
HLA-DQA2	-5446.5
HLA-DQA1	-8119.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD3D	9774.5
LCK	9746.5
CD3G	9724.5
CD3E	9685.5
HLA-DRB1	9265.5
PTPN6	9094.5
PDCD1	8650.5
CD274	8231.5
HLA-DRA	8025.5
CSK	7828.5
HLA-DQB1	7351.5
PTPN11	7001.5
CD4	6152.5
CD247	5800.5
HLA-DRB5	0.5
PDCD1LG2	-905.5
HLA-DPA1	-1907.5
HLA-DQB2	-2780.5
HLA-DQA2	-5446.5
HLA-DQA1	-8119.5
HLA-DPB1	-9425.5

---

Viral mRNA Translation

Viral mRNA Translation

	1470
set	Viral mRNA Translation
setSize	84
pANOVA	2.4e-12
s.dist	0.442
p.adjustANOVA	1.66e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5
RPS21	7800.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
RPL7	7560.5
RPL23	7452.5
FAU	7219.5
RPSA	6921.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
GRSF1	5827.5
RPL30	5424.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
DNAJC3	5049.5
UBA52	4851.5
RPL35A	4742.5
RPL11	4727.5
RPS26	4696.5
RPL28	4530.5
RPS25	4215.5
RPL15	4146.5
RPL17	3881.5
RPL27A	3799.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
RPS7	3074.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
RPS9	2072.5
RPS16	1569.5
RPL31	1252.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
RPS3	-2710.5
RPL37	-2940.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
RPL22L1	-3698.5
RPL27	-4466.5
RPL26L1	-6272.5
RPLP1	-7811.5

---

Resolution of D-loop Structures through Holliday Junction Intermediates

Resolution of D-loop Structures through Holliday Junction Intermediates

	1124
set	Resolution of D-loop Structures through Holliday Junction Intermediates
setSize	25
pANOVA	0.000136
s.dist	0.441
p.adjustANOVA	0.00103

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATM	9456.5
EME2	9069.5
RBBP8	8079.5
KAT5	8049.5
RAD51	7769.5
RAD51C	7565.5
WRN	7414.5
GEN1	7412.5
BLM	7363.5
EXO1	7107.5
MUS81	6508.5
BRCA2	6317.5
RMI1	5892.5
BRCA1	4960.5
RAD50	4699.5
RAD51AP1	4657.5
TOP3A	3524.5
XRCC3	2991.5
XRCC2	2529.5
EME1	907.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATM	9456.5
EME2	9069.5
RBBP8	8079.5
KAT5	8049.5
RAD51	7769.5
RAD51C	7565.5
WRN	7414.5
GEN1	7412.5
BLM	7363.5
EXO1	7107.5
MUS81	6508.5
BRCA2	6317.5
RMI1	5892.5
BRCA1	4960.5
RAD50	4699.5
RAD51AP1	4657.5
TOP3A	3524.5
XRCC3	2991.5
XRCC2	2529.5
EME1	907.5
PALB2	-1558.5
NBN	-2358.5
DNA2	-3615.5
BARD1	-3997.5
BRIP1	-6748.5

---

Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis

	964
set	Purine ribonucleoside monophosphate biosynthesis
setSize	11
pANOVA	0.0115
s.dist	0.44
p.adjustANOVA	0.0416

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATIC	9564.5
IMPDH2	9427.5
GART	8023.5
PFAS	7134.5
PAICS	6511.5
ADSL	6362.5
PPAT	4364.5
ADSSL1	3938.5
ADSS	1133.5
GMPS	-1981.5
IMPDH1	-8756.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATIC	9564.5
IMPDH2	9427.5
GART	8023.5
PFAS	7134.5
PAICS	6511.5
ADSL	6362.5
PPAT	4364.5
ADSSL1	3938.5
ADSS	1133.5
GMPS	-1981.5
IMPDH1	-8756.5

---

PECAM1 interactions

PECAM1 interactions

	858
set	PECAM1 interactions
setSize	12
pANOVA	0.00864
s.dist	0.438
p.adjustANOVA	0.0328

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	9746.5
PECAM1	9257.5
PLCG1	9168.5
PTPN6	9094.5
FYN	8340.5
PTPN11	7001.5
ITGAV	5960.5
ITGB3	3006.5
INPP5D	826.5
SRC	-2719.5
YES1	-3798.5
LYN	-6288.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	9746.5
PECAM1	9257.5
PLCG1	9168.5
PTPN6	9094.5
FYN	8340.5
PTPN11	7001.5
ITGAV	5960.5
ITGB3	3006.5
INPP5D	826.5
SRC	-2719.5
YES1	-3798.5
LYN	-6288.5

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	393
set	Eukaryotic Translation Termination
setSize	87
pANOVA	1.87e-12
s.dist	0.437
p.adjustANOVA	1.35e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
ETF1	8180.5
RPS29	8056.5
RPL29	7935.5
TRMT112	7883.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
ETF1	8180.5
RPS29	8056.5
RPL29	7935.5
TRMT112	7883.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
RPL7	7560.5
RPL23	7452.5
FAU	7219.5
RPSA	6921.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
RPL30	5424.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
UBA52	4851.5
RPL35A	4742.5
RPL11	4727.5
RPS26	4696.5
RPL28	4530.5
N6AMT1	4240.5
RPS25	4215.5
RPL15	4146.5
RPL17	3881.5
RPL27A	3799.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
RPS7	3074.5
APEH	2737.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
RPS9	2072.5
RPS16	1569.5
RPL31	1252.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
RPS3	-2710.5
RPL37	-2940.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
RPL22L1	-3698.5
RPL27	-4466.5
GSPT1	-4503.5
RPL26L1	-6272.5
RPLP1	-7811.5

---

Peptide chain elongation

Peptide chain elongation

	891
set	Peptide chain elongation
setSize	84
pANOVA	5.53e-12
s.dist	0.435
p.adjustANOVA	3.5e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5
RPS21	7800.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
RPL7	7560.5
RPL23	7452.5
FAU	7219.5
RPSA	6921.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
RPL30	5424.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
UBA52	4851.5
RPL35A	4742.5
RPL11	4727.5
RPS26	4696.5
RPL28	4530.5
RPS25	4215.5
RPL15	4146.5
RPL17	3881.5
RPL27A	3799.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
EEF1A1	3246.5
RPS7	3074.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
RPS9	2072.5
RPS16	1569.5
EEF2	1413.5
RPL31	1252.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
RPS3	-2710.5
RPL37	-2940.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
RPL22L1	-3698.5
RPL27	-4466.5
RPL26L1	-6272.5
RPLP1	-7811.5

---

Regulation of FZD by ubiquitination

Regulation of FZD by ubiquitination

	1070
set	Regulation of FZD by ubiquitination
setSize	21
pANOVA	0.000562
s.dist	-0.435
p.adjustANOVA	0.0035

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RSPO2	-10085.5
LRP6	-9973.5
WNT3A	-9927.5
LGR5	-9006.5
FZD8	-8968.5
LGR6	-8321.5
RSPO1	-8193.5
FZD6	-8025.5
RSPO3	-7014.5
RSPO4	-6267.5
FZD5	-5743.5
USP8	-5123.5
LGR4	-3400.5
FZD4	-3201.5
LRP5	-2430.5
UBB	-1390.5
RPS27A	-1067.5
RNF43	0.5
ZNRF3	819.5
UBA52	4851.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RSPO2	-10085.5
LRP6	-9973.5
WNT3A	-9927.5
LGR5	-9006.5
FZD8	-8968.5
LGR6	-8321.5
RSPO1	-8193.5
FZD6	-8025.5
RSPO3	-7014.5
RSPO4	-6267.5
FZD5	-5743.5
USP8	-5123.5
LGR4	-3400.5
FZD4	-3201.5
LRP5	-2430.5
UBB	-1390.5
RPS27A	-1067.5
RNF43	0.5
ZNRF3	819.5
UBA52	4851.5
UBC	5351.5

---

CASP8 activity is inhibited

CASP8 activity is inhibited

	132
set	CASP8 activity is inhibited
setSize	11
pANOVA	0.0126
s.dist	0.434
p.adjustANOVA	0.0446

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FASLG	9522.5
CFLAR	8648.5
TRAF2	8006.5
FAS	7802.5
CASP8	5678.5
TRADD	3992.5
TNFSF10	3782.5
TNFRSF10A	3040.5
TNFRSF10B	1359.5
RIPK1	1327.5
FADD	-8084.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FASLG	9522.5
CFLAR	8648.5
TRAF2	8006.5
FAS	7802.5
CASP8	5678.5
TRADD	3992.5
TNFSF10	3782.5
TNFRSF10A	3040.5
TNFRSF10B	1359.5
RIPK1	1327.5
FADD	-8084.5

---

Dimerization of procaspase-8

Dimerization of procaspase-8

	315
set	Dimerization of procaspase-8
setSize	11
pANOVA	0.0126
s.dist	0.434
p.adjustANOVA	0.0446

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FASLG	9522.5
CFLAR	8648.5
TRAF2	8006.5
FAS	7802.5
CASP8	5678.5
TRADD	3992.5
TNFSF10	3782.5
TNFRSF10A	3040.5
TNFRSF10B	1359.5
RIPK1	1327.5
FADD	-8084.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FASLG	9522.5
CFLAR	8648.5
TRAF2	8006.5
FAS	7802.5
CASP8	5678.5
TRADD	3992.5
TNFSF10	3782.5
TNFRSF10A	3040.5
TNFRSF10B	1359.5
RIPK1	1327.5
FADD	-8084.5

---

Regulation by c-FLIP

Regulation by c-FLIP

	1065
set	Regulation by c-FLIP
setSize	11
pANOVA	0.0126
s.dist	0.434
p.adjustANOVA	0.0446

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FASLG	9522.5
CFLAR	8648.5
TRAF2	8006.5
FAS	7802.5
CASP8	5678.5
TRADD	3992.5
TNFSF10	3782.5
TNFRSF10A	3040.5
TNFRSF10B	1359.5
RIPK1	1327.5
FADD	-8084.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FASLG	9522.5
CFLAR	8648.5
TRAF2	8006.5
FAS	7802.5
CASP8	5678.5
TRADD	3992.5
TNFSF10	3782.5
TNFRSF10A	3040.5
TNFRSF10B	1359.5
RIPK1	1327.5
FADD	-8084.5

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	1149
set	SARS-CoV-2 modulates host translation machinery
setSize	45
pANOVA	5.6e-07
s.dist	0.431
p.adjustANOVA	1.29e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPS11	9417.5
RPS27L	9408.5
SNRPD2	8977.5
SNRPD3	8336.5
RPS29	8056.5
SNRPD1	7871.5
RPS21	7800.5
RPS14	7598.5
FAU	7219.5
DDX20	7039.5
RPSA	6921.5
RPS23	6740.5
SNRPG	6730.5
RPS8	6564.5
RPS10	6221.5
RPS6	6036.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPS11	9417.5
RPS27L	9408.5
SNRPD2	8977.5
SNRPD3	8336.5
RPS29	8056.5
SNRPD1	7871.5
RPS21	7800.5
RPS14	7598.5
FAU	7219.5
DDX20	7039.5
RPSA	6921.5
RPS23	6740.5
SNRPG	6730.5
RPS8	6564.5
RPS10	6221.5
RPS6	6036.5
RPS28	5241.5
RPS15	5126.5
RPS26	4696.5
RPS25	4215.5
SNRPE	3944.5
RPS5	3697.5
RPS7	3074.5
GEMIN7	2746.5
SNRPF	2498.5
SNRPB	2362.5
RPS3A	2249.5
RPS9	2072.5
RPS16	1569.5
GEMIN4	1341.5
SMN1	0.5
RPS17	0.5
RPS27A	-1067.5
RPS13	-1617.5
GEMIN6	-2108.5
RPS24	-2321.5
RPS27	-2352.5
RPS3	-2710.5
RPS20	-3076.5
RPS19	-3228.5
GEMIN5	-3462.5

---

Nucleotide biosynthesis

Nucleotide biosynthesis

	832
set	Nucleotide biosynthesis
setSize	14
pANOVA	0.00525
s.dist	0.431
p.adjustANOVA	0.0218

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATIC	9564.5
IMPDH2	9427.5
GART	8023.5
PFAS	7134.5
PAICS	6511.5
ADSL	6362.5
UMPS	4911.5
PPAT	4364.5
ADSSL1	3938.5
CAD	3511.5
DHODH	2731.5
ADSS	1133.5
GMPS	-1981.5
IMPDH1	-8756.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATIC	9564.5
IMPDH2	9427.5
GART	8023.5
PFAS	7134.5
PAICS	6511.5
ADSL	6362.5
UMPS	4911.5
PPAT	4364.5
ADSSL1	3938.5
CAD	3511.5
DHODH	2731.5
ADSS	1133.5
GMPS	-1981.5
IMPDH1	-8756.5

---

E2F mediated regulation of DNA replication

E2F mediated regulation of DNA replication

	354
set	E2F mediated regulation of DNA replication
setSize	14
pANOVA	0.00542
s.dist	0.429
p.adjustANOVA	0.0223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R1A	9104.5
PRIM1	8998.5
PPP2R1B	7867.5
CCNB1	7123.5
POLA2	7012.5
PPP2CA	6873.5
E2F1	6779.5
MCM8	6537.0
PRIM2	4062.5
CDK1	4025.0
PPP2CB	2373.5
TFDP2	0.5
RB1	-4708.5
TFDP1	-9393.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R1A	9104.5
PRIM1	8998.5
PPP2R1B	7867.5
CCNB1	7123.5
POLA2	7012.5
PPP2CA	6873.5
E2F1	6779.5
MCM8	6537.0
PRIM2	4062.5
CDK1	4025.0
PPP2CB	2373.5
TFDP2	0.5
RB1	-4708.5
TFDP1	-9393.5

---

MASTL Facilitates Mitotic Progression

MASTL Facilitates Mitotic Progression

	685
set	MASTL Facilitates Mitotic Progression
setSize	10
pANOVA	0.0192
s.dist	0.428
p.adjustANOVA	0.0617

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R1A	9104.5
PPP2R1B	7867.5
CCNB1	7123.5
PPP2CA	6873.5
ENSA	4868.5
CDK1	4025.0
ARPP19	3696.5
PPP2CB	2373.5
MASTL	883.5
PPP2R2D	-6490.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R1A	9104.5
PPP2R1B	7867.5
CCNB1	7123.5
PPP2CA	6873.5
ENSA	4868.5
CDK1	4025.0
ARPP19	3696.5
PPP2CB	2373.5
MASTL	883.5
PPP2R2D	-6490.5

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	391
set	Eukaryotic Translation Elongation
setSize	88
pANOVA	4.27e-12
s.dist	0.427
p.adjustANOVA	2.82e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
EEF1B2	8767.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
RPL39L	9091.5
EEF1B2	8767.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
RPS29	8056.5
RPL29	7935.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
RPL7	7560.5
RPL23	7452.5
FAU	7219.5
EEF1G	7174.5
RPSA	6921.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
RPL30	5424.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
UBA52	4851.5
RPL35A	4742.5
RPL11	4727.5
RPS26	4696.5
RPL28	4530.5
RPS25	4215.5
RPL15	4146.5
RPL17	3881.5
RPL27A	3799.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
EEF1A1	3246.5
RPS7	3074.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
RPS9	2072.5
RPS16	1569.5
EEF2	1413.5
RPL31	1252.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
RPS3	-2710.5
RPL37	-2940.5
EEF1A2	-3020.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
EEF1D	-3421.5
RPL22L1	-3698.5
RPL27	-4466.5
RPL26L1	-6272.5
RPLP1	-7811.5

---

Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

	1112
set	Regulation of ornithine decarboxylase (ODC)
setSize	49
pANOVA	3.63e-07
s.dist	0.42
p.adjustANOVA	8.77e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB8	9773.5
PSMB9	9709.5
AZIN1	9636.5
PSMD3	9453.5
PSME4	9400.5
PSMA2	9252.5
ODC1	9245.5
PSMA5	8662.5
PSMD13	8380.5
PSMB3	8343.5
PSMB11	8338.5
PSMA4	8185.5
PSMA3	7810.5
OAZ2	7478.5
NQO1	7416.5
PSMB6	6784.5
PSMC6	6599.5
PSMD7	6347.5
PSMC2	6264.5
PSMB4	6046.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB8	9773.5
PSMB9	9709.5
AZIN1	9636.5
PSMD3	9453.5
PSME4	9400.5
PSMA2	9252.5
ODC1	9245.5
PSMA5	8662.5
PSMD13	8380.5
PSMB3	8343.5
PSMB11	8338.5
PSMA4	8185.5
PSMA3	7810.5
OAZ2	7478.5
NQO1	7416.5
PSMB6	6784.5
PSMC6	6599.5
PSMD7	6347.5
PSMC2	6264.5
PSMB4	6046.5
PSMD2	5987.5
PSMD8	5589.5
PSME2	5310.5
PSMD6	5150.5
PSMC4	5141.5
PSME1	5117.5
PSMD9	5086.5
PSMD11	4273.5
PSMD12	4227.5
PSMA1	4031.5
PSMA6	3874.5
PSMB1	3471.5
PSMB5	2823.5
PSMD14	2431.5
OAZ1	2423.5
PSMD4	1595.5
PSMA7	1242.5
PSMD1	1019.5
PSMC5	0.5
PSMD5	-933.5
OAZ3	-1124.5
PSME3	-1661.5
PSMF1	-2002.5
PSMC1	-2373.5
PSMB10	-2439.5
PSMC3	-4458.5
PSMA8	-6030.5
PSMB7	-8588.5
PSMB2	-8937.5

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	816
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	106
pANOVA	8.57e-14
s.dist	0.419
p.adjustANOVA	1e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
PPP2R1A	9104.5
RPL39L	9091.5
EIF4A3	8625.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
ETF1	8180.5
RPS29	8056.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
PPP2R1A	9104.5
RPL39L	9091.5
EIF4A3	8625.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
ETF1	8180.5
RPS29	8056.5
SMG5	7942.5
RPL29	7935.5
RBM8A	7843.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
SMG7	7579.5
RPL7	7560.5
RPL23	7452.5
FAU	7219.5
RNPS1	7080.5
NCBP1	6996.5
RPSA	6921.5
PPP2CA	6873.5
UPF2	6864.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
NCBP2	5887.5
RPL30	5424.5
UPF3A	5338.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
UBA52	4851.5
RPL35A	4742.5
RPL11	4727.5
RPS26	4696.5
MAGOHB	4596.5
RPL28	4530.5
RPS25	4215.5
RPL15	4146.5
RPL17	3881.5
RPL27A	3799.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
RPS7	3074.5
PPP2R2A	2733.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
DCP1A	2229.5
SMG1	2148.5
MAGOH	2139.5
RPS9	2072.5
RPS16	1569.5
RPL31	1252.5
PNRC2	1245.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
PABPC1	-1360.5
CASC3	-1593.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
RPS3	-2710.5
RPL37	-2940.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
RPL22L1	-3698.5
RPL27	-4466.5
GSPT1	-4503.5
SMG6	-5110.5
EIF4G1	-5509.5
RPL26L1	-6272.5
UPF1	-7724.5
RPLP1	-7811.5

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	818
set	Nonsense-Mediated Decay (NMD)
setSize	106
pANOVA	8.57e-14
s.dist	0.419
p.adjustANOVA	1e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
PPP2R1A	9104.5
RPL39L	9091.5
EIF4A3	8625.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
ETF1	8180.5
RPS29	8056.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	9740.5
RPS2	9715.5
RPS18	9680.5
RPS15A	9671.5
RPL23A	9481.5
RPS11	9417.5
RPS27L	9408.5
RPL13A	9236.0
RPL10A	9200.5
RPLP2	9189.5
RPL7A	9124.5
RPL13	9123.5
PPP2R1A	9104.5
RPL39L	9091.5
EIF4A3	8625.5
RPL41	8502.5
RPL3	8459.5
RPL24	8262.5
ETF1	8180.5
RPS29	8056.5
SMG5	7942.5
RPL29	7935.5
RBM8A	7843.5
RPL36	7826.5
RPS21	7800.5
RPL36AL	7717.5
RPL5	7671.5
RPS14	7598.5
SMG7	7579.5
RPL7	7560.5
RPL23	7452.5
FAU	7219.5
RNPS1	7080.5
NCBP1	6996.5
RPSA	6921.5
PPP2CA	6873.5
UPF2	6864.5
RPS23	6740.5
RPLP0	6648.5
RPS8	6564.5
RPL12	6357.5
RPS10	6221.5
RPL8	6171.5
RPL6	6066.5
RPS6	6036.5
NCBP2	5887.5
RPL30	5424.5
UPF3A	5338.5
RPL35	5325.5
RPL3L	5271.5
RPS28	5241.5
RPL18A	5184.5
RPS15	5126.5
RPL10L	5099.5
UBA52	4851.5
RPL35A	4742.5
RPL11	4727.5
RPS26	4696.5
MAGOHB	4596.5
RPL28	4530.5
RPS25	4215.5
RPL15	4146.5
RPL17	3881.5
RPL27A	3799.5
RPS5	3697.5
RPL14	3683.5
RPL18	3528.5
RPL9	3472.5
RPL34	3333.5
RPS7	3074.5
PPP2R2A	2733.5
RPL38	2314.5
RPL4	2264.5
RPS3A	2249.5
DCP1A	2229.5
SMG1	2148.5
MAGOH	2139.5
RPS9	2072.5
RPS16	1569.5
RPL31	1252.5
PNRC2	1245.5
RPS17	0.5
RPL22	-824.5
RPS27A	-1067.5
RPL19	-1197.5
RPL26	-1227.5
RPL37A	-1349.5
PABPC1	-1360.5
CASC3	-1593.5
RPS13	-1617.5
RPS24	-2321.5
RPS27	-2352.5
RPL32	-2531.5
RPS3	-2710.5
RPL37	-2940.5
RPS20	-3076.5
RPS19	-3228.5
RPL21	-3286.0
RPL22L1	-3698.5
RPL27	-4466.5
GSPT1	-4503.5
SMG6	-5110.5
EIF4G1	-5509.5
RPL26L1	-6272.5
UPF1	-7724.5
RPLP1	-7811.5

---

Neurotoxicity of clostridium toxins

Neurotoxicity of clostridium toxins

	806
set	Neurotoxicity of clostridium toxins
setSize	10
pANOVA	0.0219
s.dist	-0.419
p.adjustANOVA	0.0687

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNAP25	-9847.5
SYT2	-9336.5
STX1B	-8799.5
SV2C	-7568.5
STX1A	-6127.5
SYT1	-4800.5
SV2A	-4792.5
SV2B	-3416.5
VAMP2	3660.5
VAMP1	6371.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNAP25	-9847.5
SYT2	-9336.5
STX1B	-8799.5
SV2C	-7568.5
STX1A	-6127.5
SYT1	-4800.5
SV2A	-4792.5
SV2B	-3416.5
VAMP2	3660.5
VAMP1	6371.5

---

Adenylate cyclase inhibitory pathway

Adenylate cyclase inhibitory pathway

	65
set	Adenylate cyclase inhibitory pathway
setSize	14
pANOVA	0.00697
s.dist	-0.416
p.adjustANOVA	0.0278

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY9	-9666.5
ADCY8	-9621.5
ADCY7	-9583.5
ADCY4	-7351.5
GNAI1	-6884.5
GNAT3	-6433.5
GNAL	-6403.5
ADCY6	-5223.5
ADCY1	-4967.5
ADCY2	-4301.5
GNAI2	-3213.5
ADCY5	939.5
ADCY3	5031.5
GNAI3	5477.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY9	-9666.5
ADCY8	-9621.5
ADCY7	-9583.5
ADCY4	-7351.5
GNAI1	-6884.5
GNAT3	-6433.5
GNAL	-6403.5
ADCY6	-5223.5
ADCY1	-4967.5
ADCY2	-4301.5
GNAI2	-3213.5
ADCY5	939.5
ADCY3	5031.5
GNAI3	5477.5

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

	950
set	Processing of Intronless Pre-mRNAs
setSize	19
pANOVA	0.00169
s.dist	0.416
p.adjustANOVA	0.00879

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CPSF2	8021.5
NUDT21	7461.5
CLP1	7345.5
CSTF2T	7052.5
NCBP1	6996.5
CPSF4	6967.5
PCF11	6327.5
PABPN1	6011.5
CPSF6	5928.5
NCBP2	5887.5
CSTF1	5284.5
CPSF7	4841.5
CPSF1	3049.5
CPSF3	1884.5
FIP1L1	1030.5
PAPOLA	-765.5
WDR33	-2221.5
CSTF3	-2861.5
SYMPK	-3884.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CPSF2	8021.5
NUDT21	7461.5
CLP1	7345.5
CSTF2T	7052.5
NCBP1	6996.5
CPSF4	6967.5
PCF11	6327.5
PABPN1	6011.5
CPSF6	5928.5
NCBP2	5887.5
CSTF1	5284.5
CPSF7	4841.5
CPSF1	3049.5
CPSF3	1884.5
FIP1L1	1030.5
PAPOLA	-765.5
WDR33	-2221.5
CSTF3	-2861.5
SYMPK	-3884.5

---

Adherens junctions interactions

Adherens junctions interactions

	66
set	Adherens junctions interactions
setSize	26
pANOVA	0.00024
s.dist	-0.416
p.adjustANOVA	0.00168

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDH7	-10059.5
CADM2	-10025.5
CDH1	-10015.5
CDH8	-9696.5
CDH2	-9681.5
CTNND1	-9596.5
CDH6	-8745.5
CDH3	-7380.5
CDH24	-7185.5
CDH5	-7131.5
CADM1	-6191.5
CTNNB1	-5972.5
CDH13	-4678.5
JUP	-4453.5
CDH12	-3750.5
CTNNA1	-3717.5
CDH18	-3458.5
CDH15	-3031.5
PVR	-1968.5
CDH4	-1873.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDH7	-10059.5
CADM2	-10025.5
CDH1	-10015.5
CDH8	-9696.5
CDH2	-9681.5
CTNND1	-9596.5
CDH6	-8745.5
CDH3	-7380.5
CDH24	-7185.5
CDH5	-7131.5
CADM1	-6191.5
CTNNB1	-5972.5
CDH13	-4678.5
JUP	-4453.5
CDH12	-3750.5
CTNNA1	-3717.5
CDH18	-3458.5
CDH15	-3031.5
PVR	-1968.5
CDH4	-1873.5
CADM3	-931.5
CDH9	0.5
CDH17	0.5
CDH10	4107.5
CDH11	4906.5
ANG	5203.5

---

Metabolism of polyamines

Metabolism of polyamines

	716
set	Metabolism of polyamines
setSize	54
pANOVA	1.23e-07
s.dist	0.416
p.adjustANOVA	3.29e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB8	9773.5
PSMB9	9709.5
AZIN1	9636.5
PSMD3	9453.5
PSME4	9400.5
PSMA2	9252.5
ODC1	9245.5
PSMA5	8662.5
PAOX	8543.5
PSMD13	8380.5
PSMB3	8343.5
PSMB11	8338.5
PSMA4	8185.5
SRM	8103.5
PSMA3	7810.5
OAZ2	7478.5
NQO1	7416.5
PSMB6	6784.5
PSMC6	6599.5
PSMD7	6347.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB8	9773.5
PSMB9	9709.5
AZIN1	9636.5
PSMD3	9453.5
PSME4	9400.5
PSMA2	9252.5
ODC1	9245.5
PSMA5	8662.5
PAOX	8543.5
PSMD13	8380.5
PSMB3	8343.5
PSMB11	8338.5
PSMA4	8185.5
SRM	8103.5
PSMA3	7810.5
OAZ2	7478.5
NQO1	7416.5
PSMB6	6784.5
PSMC6	6599.5
PSMD7	6347.5
SMOX	6308.5
PSMC2	6264.5
PSMB4	6046.5
PSMD2	5987.5
PSMD8	5589.5
PSME2	5310.5
PSMD6	5150.5
PSMC4	5141.5
PSME1	5117.5
PSMD9	5086.5
PSMD11	4273.5
PSMD12	4227.5
PSMA1	4031.5
PSMA6	3874.5
PSMB1	3471.5
PSMB5	2823.5
PSMD14	2431.5
OAZ1	2423.5
PSMD4	1595.5
PSMA7	1242.5
PSMD1	1019.5
PSMC5	0.5
AGMAT	0.5
PSMD5	-933.5
OAZ3	-1124.5
PSME3	-1661.5
PSMF1	-2002.5
PSMC1	-2373.5
PSMB10	-2439.5
PSMC3	-4458.5
AMD1	-5460.5
PSMA8	-6030.5
PSMB7	-8588.5
PSMB2	-8937.5

---

Serotonin Neurotransmitter Release Cycle

Serotonin Neurotransmitter Release Cycle

	1201
set	Serotonin Neurotransmitter Release Cycle
setSize	16
pANOVA	0.00399
s.dist	-0.416
p.adjustANOVA	0.0177

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNAP25	-9847.5
RIMS1	-9673.5
PPFIA2	-9579.5
RAB3A	-8759.5
SYN3	-8061.5
SLC18A2	-7367.5
CPLX1	-7172.5
STX1A	-6127.5
PPFIA3	-5718.5
SYN2	-5008.5
SYT1	-4800.5
PPFIA1	-2284.5
UNC13B	0.5
STXBP1	1518.5
VAMP2	3660.5
PPFIA4	8268.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNAP25	-9847.5
RIMS1	-9673.5
PPFIA2	-9579.5
RAB3A	-8759.5
SYN3	-8061.5
SLC18A2	-7367.5
CPLX1	-7172.5
STX1A	-6127.5
PPFIA3	-5718.5
SYN2	-5008.5
SYT1	-4800.5
PPFIA1	-2284.5
UNC13B	0.5
STXBP1	1518.5
VAMP2	3660.5
PPFIA4	8268.5

---

GRB2 events in ERBB2 signaling

GRB2 events in ERBB2 signaling

	486
set	GRB2 events in ERBB2 signaling
setSize	16
pANOVA	0.00406
s.dist	-0.415
p.adjustANOVA	0.018

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EREG	-9073.5
HBEGF	-8952.5
KRAS	-8903.5
NRG1	-8678.5
HRAS	-6539.5
ERBB4	-5776.5
EGFR	-5339.5
ERBB2	-5277.5
NRG3	-4974.5
NRG4	-4932.5
EGF	-4659.5
BTC	-3088.5
NRG2	-1145.5
NRAS	-881.5
GRB2	2726.5
SOS1	4666.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EREG	-9073.5
HBEGF	-8952.5
KRAS	-8903.5
NRG1	-8678.5
HRAS	-6539.5
ERBB4	-5776.5
EGFR	-5339.5
ERBB2	-5277.5
NRG3	-4974.5
NRG4	-4932.5
EGF	-4659.5
BTC	-3088.5
NRG2	-1145.5
NRAS	-881.5
GRB2	2726.5
SOS1	4666.5

---

HDR through MMEJ (alt-NHEJ)

HDR through MMEJ (alt-NHEJ)

	538
set	HDR through MMEJ (alt-NHEJ)
setSize	11
pANOVA	0.0176
s.dist	0.413
p.adjustANOVA	0.0578

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FEN1	9073.5
POLQ	8493.5
RBBP8	8079.5
XRCC1	7745.5
BRCA2	6317.5
LIG3	5507.5
RAD50	4699.5
PARP1	1301.5
PARP2	0.5
NBN	-2358.5
RAD52	-6108.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FEN1	9073.5
POLQ	8493.5
RBBP8	8079.5
XRCC1	7745.5
BRCA2	6317.5
LIG3	5507.5
RAD50	4699.5
PARP1	1301.5
PARP2	0.5
NBN	-2358.5
RAD52	-6108.5

---

Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA

	948
set	Processing of Capped Intronless Pre-mRNA
setSize	28
pANOVA	0.000158
s.dist	0.412
p.adjustANOVA	0.00117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLBP	9026.5
SNRPD3	8336.5
ZNF473	8159.5
CPSF2	8021.5
NUDT21	7461.5
CLP1	7345.5
CSTF2T	7052.5
NCBP1	6996.5
CPSF4	6967.5
SNRPG	6730.5
PCF11	6327.5
PABPN1	6011.5
CPSF6	5928.5
NCBP2	5887.5
CSTF1	5284.5
CPSF7	4841.5
SNRPE	3944.5
CPSF1	3049.5
SNRPF	2498.5
SNRPB	2362.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLBP	9026.5
SNRPD3	8336.5
ZNF473	8159.5
CPSF2	8021.5
NUDT21	7461.5
CLP1	7345.5
CSTF2T	7052.5
NCBP1	6996.5
CPSF4	6967.5
SNRPG	6730.5
PCF11	6327.5
PABPN1	6011.5
CPSF6	5928.5
NCBP2	5887.5
CSTF1	5284.5
CPSF7	4841.5
SNRPE	3944.5
CPSF1	3049.5
SNRPF	2498.5
SNRPB	2362.5
CPSF3	1884.5
FIP1L1	1030.5
PAPOLA	-765.5
LSM11	-1511.5
WDR33	-2221.5
CSTF3	-2861.5
SYMPK	-3884.5
LSM10	-5407.5

---

Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition

	241
set	Cyclin A/B1/B2 associated events during G2/M transition
setSize	24
pANOVA	0.000488
s.dist	0.411
p.adjustANOVA	0.00311

Top enriched genes

Top 20 genes

GeneID	Gene Rank
XPO1	9271.5
PPP2R1A	9104.5
CCNB2	9048.5
WEE1	8814.5
CDC25B	8392.5
CCNA2	8107.5
PPME1	7960.5
PPP2R1B	7867.5
CCNH	7732.5
CCNB1	7123.5
CDK7	6894.5
PPP2CA	6873.5
CDK1	4025.0
MNAT1	3724.5
FOXM1	3218.5
PPP2R2A	2733.5
PPP2CB	2373.5
LCMT1	1858.5
PKMYT1	0.5
CDC25A	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
XPO1	9271.5
PPP2R1A	9104.5
CCNB2	9048.5
WEE1	8814.5
CDC25B	8392.5
CCNA2	8107.5
PPME1	7960.5
PPP2R1B	7867.5
CCNH	7732.5
CCNB1	7123.5
CDK7	6894.5
PPP2CA	6873.5
CDK1	4025.0
MNAT1	3724.5
FOXM1	3218.5
PPP2R2A	2733.5
PPP2CB	2373.5
LCMT1	1858.5
PKMYT1	0.5
CDC25A	0.5
PLK1	-1312.5
CDC25C	-3732.5
CDK2	-7664.5
CCNA1	-9687.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.2.4    GGally_2.1.2     ggplot2_3.3.5    reshape2_1.4.4  
##  [5] beeswarm_0.4.0   gplots_3.1.1     gtools_3.9.2     tibble_3.1.6    
##  [9] echarts4r_0.4.3  mitch_1.4.1      eulerr_6.1.1     kableExtra_1.3.4
## [13] dplyr_1.0.8     
## 
## loaded via a namespace (and not attached):
##  [1] httr_1.4.2         sass_0.4.1         jsonlite_1.8.0     viridisLite_0.4.0 
##  [5] brio_1.1.3         bslib_0.3.1        shiny_1.7.1        assertthat_0.2.1  
##  [9] highr_0.9          yaml_2.3.5         pillar_1.7.0       glue_1.6.2        
## [13] digest_0.6.29      RColorBrewer_1.1-3 promises_1.2.0.1   rvest_1.0.2       
## [17] colorspace_2.0-3   htmltools_0.5.2    httpuv_1.6.5       plyr_1.8.7        
## [21] pkgconfig_2.0.3    purrr_0.3.4        xtable_1.8-4       scales_1.1.1      
## [25] webshot_0.5.2      svglite_2.1.0      later_1.3.0        generics_0.1.2    
## [29] ellipsis_0.3.2     withr_2.5.0        cli_3.2.0          magrittr_2.0.3    
## [33] crayon_1.5.1       mime_0.12          evaluate_0.15      fansi_1.0.3       
## [37] MASS_7.3-57        xml2_1.3.3         tools_4.2.0        lifecycle_1.0.1   
## [41] stringr_1.4.0      munsell_0.5.0      compiler_4.2.0     jquerylib_0.1.4   
## [45] caTools_1.18.2     systemfonts_1.0.4  rlang_1.0.2        grid_4.2.0        
## [49] rstudioapi_0.13    htmlwidgets_1.5.4  bitops_1.0-7       rmarkdown_2.13    
## [53] testthat_3.1.3     gtable_0.3.0       DBI_1.1.2          reshape_0.8.8     
## [57] R6_2.5.1           gridExtra_2.3      knitr_1.38         fastmap_1.1.0     
## [61] utf8_1.2.2         rprojroot_2.0.3    KernSmooth_2.23-20 desc_1.4.1        
## [65] stringi_1.7.6      Rcpp_1.0.8.3       vctrs_0.4.0        tidyselect_1.1.2  
## [69] xfun_0.30

END of report