date generated: 2022-05-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## PSMB9   3.246776
## LTA    12.198286
## ZNF331 -4.472165
## HLA-F   4.071199
## TAP1    2.586892
## PHTF2   2.585173
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 10315
duplicated_genes_present 0
num_profile_genes_in_sets 5487
num_profile_genes_not_in_sets 4828

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1354
num_genesets_included 1192

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Regulation of FZD by ubiquitination 12 0.000444 -0.585 0.0294
RUNX2 regulates osteoblast differentiation 13 0.000270 -0.583 0.0230
Glutamate Neurotransmitter Release Cycle 11 0.002300 -0.531 0.0830
Assembly of collagen fibrils and other multimeric structures 10 0.004600 -0.517 0.1170
Maturation of nucleoprotein 11 0.004740 0.492 0.1170
Voltage gated Potassium channels 10 0.007600 -0.487 0.1370
Neurotransmitter release cycle 18 0.000360 -0.486 0.0266
Regulation of pyruvate dehydrogenase (PDH) complex 11 0.006980 -0.470 0.1330
Dopamine Neurotransmitter Release Cycle 10 0.014300 -0.447 0.1870
Long-term potentiation 11 0.010500 -0.446 0.1620
PKA activation 10 0.017400 -0.434 0.2170
Signaling by Retinoic Acid 17 0.002000 -0.433 0.0770
PKA-mediated phosphorylation of CREB 11 0.013400 -0.431 0.1790
Negative regulation of NMDA receptor-mediated neuronal transmission 12 0.010600 -0.426 0.1620
RUNX2 regulates bone development 17 0.002530 -0.423 0.0861
Glycogen storage diseases 10 0.021900 -0.418 0.2360
Ras activation upon Ca2+ influx through NMDA receptor 10 0.027300 -0.403 0.2450
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 0.029600 0.397 0.2470
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 0.033400 -0.388 0.2600
Regulation of KIT signaling 10 0.035000 0.385 0.2640
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 0.008520 -0.380 0.1450
Purine catabolism 10 0.040300 0.374 0.2810
Synaptic adhesion-like molecules 10 0.042300 -0.371 0.2830
Class I peroxisomal membrane protein import 18 0.006470 0.371 0.1330
Assembly and cell surface presentation of NMDA receptors 13 0.023200 -0.363 0.2380
Signaling by Hippo 11 0.039000 -0.359 0.2810
Cell-cell junction organization 12 0.033300 -0.355 0.2600
Caspase activation via Death Receptors in the presence of ligand 10 0.054600 0.351 0.3120
Degradation of cysteine and homocysteine 10 0.057300 -0.347 0.3210
Gastrin-CREB signalling pathway via PKC and MAPK 11 0.047700 -0.345 0.2990
SARS-CoV-2 modulates autophagy 11 0.050700 0.340 0.3050
NOTCH4 Intracellular Domain Regulates Transcription 14 0.028700 0.338 0.2470
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 16 0.021100 0.333 0.2290
RUNX3 regulates NOTCH signaling 11 0.058100 0.330 0.3230
Potassium Channels 26 0.003630 -0.330 0.1060
Leading Strand Synthesis 12 0.049500 0.327 0.3000
Polymerase switching 12 0.049500 0.327 0.3000
mRNA decay by 3’ to 5’ exoribonuclease 14 0.036100 0.323 0.2680
Heparan sulfate/heparin (HS-GAG) metabolism 22 0.008890 -0.322 0.1470
Mucopolysaccharidoses 10 0.080900 -0.319 0.3750
Arachidonic acid metabolism 21 0.012200 -0.316 0.1700
Triglyceride catabolism 11 0.070500 -0.315 0.3430
STING mediated induction of host immune responses 10 0.088300 -0.311 0.3750
Rap1 signalling 11 0.076500 0.308 0.3620
Processing of Intronless Pre-mRNAs 15 0.038800 0.308 0.2810
RHO GTPases activate CIT 14 0.049600 0.303 0.3000
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 0.043400 0.301 0.2860
Josephin domain DUBs 11 0.084500 -0.300 0.3750
Transcriptional regulation of granulopoiesis 24 0.010900 -0.300 0.1620
E2F mediated regulation of DNA replication 12 0.075800 0.296 0.3620


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Regulation of FZD by ubiquitination 12 4.44e-04 -5.85e-01 0.029400
RUNX2 regulates osteoblast differentiation 13 2.70e-04 -5.83e-01 0.023000
Glutamate Neurotransmitter Release Cycle 11 2.30e-03 -5.31e-01 0.083000
Assembly of collagen fibrils and other multimeric structures 10 4.60e-03 -5.17e-01 0.117000
Maturation of nucleoprotein 11 4.74e-03 4.92e-01 0.117000
Voltage gated Potassium channels 10 7.60e-03 -4.87e-01 0.137000
Neurotransmitter release cycle 18 3.60e-04 -4.86e-01 0.026600
Regulation of pyruvate dehydrogenase (PDH) complex 11 6.98e-03 -4.70e-01 0.133000
Dopamine Neurotransmitter Release Cycle 10 1.43e-02 -4.47e-01 0.187000
Long-term potentiation 11 1.05e-02 -4.46e-01 0.162000
PKA activation 10 1.74e-02 -4.34e-01 0.217000
Signaling by Retinoic Acid 17 2.00e-03 -4.33e-01 0.077000
PKA-mediated phosphorylation of CREB 11 1.34e-02 -4.31e-01 0.179000
Negative regulation of NMDA receptor-mediated neuronal transmission 12 1.06e-02 -4.26e-01 0.162000
RUNX2 regulates bone development 17 2.53e-03 -4.23e-01 0.086100
Glycogen storage diseases 10 2.19e-02 -4.18e-01 0.236000
Ras activation upon Ca2+ influx through NMDA receptor 10 2.73e-02 -4.03e-01 0.245000
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 2.96e-02 3.97e-01 0.247000
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 3.34e-02 -3.88e-01 0.260000
Regulation of KIT signaling 10 3.50e-02 3.85e-01 0.264000
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 8.52e-03 -3.80e-01 0.145000
Purine catabolism 10 4.03e-02 3.74e-01 0.281000
Synaptic adhesion-like molecules 10 4.23e-02 -3.71e-01 0.283000
Class I peroxisomal membrane protein import 18 6.47e-03 3.71e-01 0.133000
Assembly and cell surface presentation of NMDA receptors 13 2.32e-02 -3.63e-01 0.238000
Signaling by Hippo 11 3.90e-02 -3.59e-01 0.281000
Cell-cell junction organization 12 3.33e-02 -3.55e-01 0.260000
Caspase activation via Death Receptors in the presence of ligand 10 5.46e-02 3.51e-01 0.312000
Degradation of cysteine and homocysteine 10 5.73e-02 -3.47e-01 0.321000
Gastrin-CREB signalling pathway via PKC and MAPK 11 4.77e-02 -3.45e-01 0.299000
SARS-CoV-2 modulates autophagy 11 5.07e-02 3.40e-01 0.305000
NOTCH4 Intracellular Domain Regulates Transcription 14 2.87e-02 3.38e-01 0.247000
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 16 2.11e-02 3.33e-01 0.229000
RUNX3 regulates NOTCH signaling 11 5.81e-02 3.30e-01 0.323000
Potassium Channels 26 3.63e-03 -3.30e-01 0.106000
Leading Strand Synthesis 12 4.95e-02 3.27e-01 0.300000
Polymerase switching 12 4.95e-02 3.27e-01 0.300000
mRNA decay by 3’ to 5’ exoribonuclease 14 3.61e-02 3.23e-01 0.268000
Heparan sulfate/heparin (HS-GAG) metabolism 22 8.89e-03 -3.22e-01 0.147000
Mucopolysaccharidoses 10 8.09e-02 -3.19e-01 0.375000
Arachidonic acid metabolism 21 1.22e-02 -3.16e-01 0.170000
Triglyceride catabolism 11 7.05e-02 -3.15e-01 0.343000
STING mediated induction of host immune responses 10 8.83e-02 -3.11e-01 0.375000
Rap1 signalling 11 7.65e-02 3.08e-01 0.362000
Processing of Intronless Pre-mRNAs 15 3.88e-02 3.08e-01 0.281000
RHO GTPases activate CIT 14 4.96e-02 3.03e-01 0.300000
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 4.34e-02 3.01e-01 0.286000
Josephin domain DUBs 11 8.45e-02 -3.00e-01 0.375000
Transcriptional regulation of granulopoiesis 24 1.09e-02 -3.00e-01 0.162000
E2F mediated regulation of DNA replication 12 7.58e-02 2.96e-01 0.362000
HDR through MMEJ (alt-NHEJ) 11 8.93e-02 2.96e-01 0.375000
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 15 4.78e-02 2.95e-01 0.299000
Cytochrome c-mediated apoptotic response 11 9.03e-02 -2.95e-01 0.375000
The NLRP3 inflammasome 12 7.88e-02 -2.93e-01 0.368000
Diseases of carbohydrate metabolism 23 1.54e-02 -2.92e-01 0.198000
Cyclin A/B1/B2 associated events during G2/M transition 22 1.84e-02 2.90e-01 0.217000
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 32 5.00e-03 2.87e-01 0.117000
LDL clearance 12 8.58e-02 -2.86e-01 0.375000
Pyruvate metabolism 19 3.22e-02 -2.84e-01 0.257000
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 1.21e-01 2.83e-01 0.418000
Processing of Capped Intronless Pre-mRNA 23 1.89e-02 2.83e-01 0.217000
Nicotinamide salvaging 10 1.23e-01 2.82e-01 0.418000
Depolymerisation of the Nuclear Lamina 11 1.08e-01 2.80e-01 0.415000
Activation of NMDA receptors and postsynaptic events 44 1.37e-03 -2.79e-01 0.062900
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 1.12e-01 2.76e-01 0.418000
Cell junction organization 22 2.49e-02 -2.76e-01 0.240000
RHO GTPases activate PKNs 26 1.79e-02 2.68e-01 0.217000
Thrombin signalling through proteinase activated receptors (PARs) 19 4.31e-02 -2.68e-01 0.286000
Triglyceride metabolism 16 6.75e-02 -2.64e-01 0.341000
Initiation of Nuclear Envelope (NE) Reformation 17 5.96e-02 2.64e-01 0.324000
Transmission across Chemical Synapses 97 7.50e-06 -2.64e-01 0.001790
Post NMDA receptor activation events 38 5.02e-03 -2.63e-01 0.117000
Activation of kainate receptors upon glutamate binding 16 6.99e-02 -2.62e-01 0.343000
Vitamin B5 (pantothenate) metabolism 11 1.34e-01 2.61e-01 0.436000
AKT phosphorylates targets in the cytosol 13 1.03e-01 2.61e-01 0.406000
Negative regulation of FGFR1 signaling 17 6.26e-02 -2.61e-01 0.329000
Negative regulation of FGFR2 signaling 17 6.26e-02 -2.61e-01 0.329000
Negative regulation of FGFR3 signaling 17 6.26e-02 -2.61e-01 0.329000
Negative regulation of FGFR4 signaling 17 6.26e-02 -2.61e-01 0.329000
Spry regulation of FGF signaling 15 8.04e-02 -2.61e-01 0.375000
Apoptotic factor-mediated response 16 7.16e-02 -2.60e-01 0.347000
SARS-CoV-2 modulates host translation machinery 38 5.55e-03 2.60e-01 0.120000
Metabolism of fat-soluble vitamins 13 1.05e-01 -2.59e-01 0.410000
Regulation of ornithine decarboxylase (ODC) 42 3.76e-03 2.59e-01 0.106000
Membrane binding and targetting of GAG proteins 11 1.38e-01 -2.58e-01 0.436000
Synthesis And Processing Of GAG, GAGPOL Polyproteins 11 1.38e-01 -2.58e-01 0.436000
Carboxyterminal post-translational modifications of tubulin 19 5.37e-02 -2.56e-01 0.310000
KSRP (KHSRP) binds and destabilizes mRNA 15 8.66e-02 2.56e-01 0.375000
ADP signalling through P2Y purinoceptor 1 15 8.70e-02 -2.55e-01 0.375000
Glucagon signaling in metabolic regulation 17 7.03e-02 -2.54e-01 0.343000
Telomere Extension By Telomerase 19 5.60e-02 2.53e-01 0.316000
Signaling by ERBB4 29 1.88e-02 -2.52e-01 0.217000
Neurotransmitter receptors and postsynaptic signal transmission 76 1.61e-04 -2.51e-01 0.016500
Nuclear signaling by ERBB4 14 1.07e-01 -2.48e-01 0.415000
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 2.58e-02 2.48e-01 0.244000
Activation of ATR in response to replication stress 29 2.11e-02 2.47e-01 0.229000
Plasma lipoprotein clearance 23 4.14e-02 -2.46e-01 0.281000
Neuronal System 132 1.38e-06 -2.44e-01 0.000823
Signaling by Leptin 10 1.84e-01 -2.42e-01 0.497000
Metabolism of polyamines 46 4.52e-03 2.42e-01 0.117000
Activation of BAD and translocation to mitochondria 14 1.17e-01 2.42e-01 0.418000
Removal of the Flap Intermediate 12 1.50e-01 2.40e-01 0.456000
mRNA Capping 26 3.53e-02 2.39e-01 0.265000
Keratan sulfate biosynthesis 14 1.23e-01 -2.38e-01 0.418000
Regulation of beta-cell development 15 1.11e-01 2.38e-01 0.416000
DNA Damage/Telomere Stress Induced Senescence 24 4.46e-02 2.37e-01 0.291000
Downregulation of ERBB2:ERBB3 signaling 10 1.95e-01 -2.37e-01 0.505000
HDACs deacetylate histones 28 3.10e-02 2.36e-01 0.253000
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 4.00e-02 2.33e-01 0.281000
Signaling by WNT in cancer 23 5.34e-02 -2.33e-01 0.310000
Defective pyroptosis 10 2.05e-01 2.31e-01 0.521000
GPVI-mediated activation cascade 23 5.50e-02 2.31e-01 0.312000
Cell recruitment (pro-inflammatory response) 15 1.23e-01 -2.30e-01 0.418000
Purinergic signaling in leishmaniasis infection 15 1.23e-01 -2.30e-01 0.418000
Keratan sulfate/keratin metabolism 18 9.42e-02 -2.28e-01 0.385000
DARPP-32 events 19 8.79e-02 -2.26e-01 0.375000
Retinoid metabolism and transport 11 1.94e-01 -2.26e-01 0.505000
Meiotic recombination 19 8.92e-02 2.25e-01 0.375000
Regulation of RUNX1 Expression and Activity 14 1.45e-01 2.25e-01 0.450000
COPI-independent Golgi-to-ER retrograde traffic 28 4.20e-02 2.22e-01 0.283000
Inflammasomes 16 1.29e-01 -2.19e-01 0.426000
Regulation of TP53 Activity through Acetylation 27 4.90e-02 2.19e-01 0.300000
RNA Pol II CTD phosphorylation and interaction with CE 24 6.39e-02 2.19e-01 0.332000
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 6.39e-02 2.19e-01 0.332000
Negative regulation of FLT3 13 1.73e-01 2.18e-01 0.490000
Autodegradation of the E3 ubiquitin ligase COP1 43 1.36e-02 2.18e-01 0.181000
Diseases associated with glycosylation precursor biosynthesis 15 1.46e-01 -2.17e-01 0.450000
Viral mRNA Translation 69 1.94e-03 2.16e-01 0.077000
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 5.58e-04 2.16e-01 0.033200
Nonsense-Mediated Decay (NMD) 86 5.58e-04 2.16e-01 0.033200
Regulation of BACH1 activity 11 2.16e-01 -2.16e-01 0.535000
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.79e-01 2.15e-01 0.497000
Negative regulation of NOTCH4 signaling 47 1.07e-02 2.15e-01 0.162000
Signaling by NODAL 11 2.17e-01 -2.15e-01 0.537000
Amino acid transport across the plasma membrane 16 1.38e-01 -2.14e-01 0.436000
Signaling by Activin 11 2.21e-01 -2.13e-01 0.541000
Glycosaminoglycan metabolism 63 3.49e-03 -2.13e-01 0.104000
Lagging Strand Synthesis 17 1.29e-01 2.13e-01 0.426000
HATs acetylate histones 54 6.93e-03 2.13e-01 0.133000
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 2.23e-01 2.12e-01 0.542000
Impaired BRCA2 binding to RAD51 30 4.54e-02 2.11e-01 0.292000
NRIF signals cell death from the nucleus 13 1.88e-01 -2.11e-01 0.499000
Assembly Of The HIV Virion 13 1.89e-01 -2.11e-01 0.500000
Regulation of expression of SLITs and ROBOs 122 6.19e-05 2.10e-01 0.009350
Miscellaneous transport and binding events 14 1.75e-01 -2.09e-01 0.491000
Stabilization of p53 48 1.23e-02 2.09e-01 0.170000
FOXO-mediated transcription of cell death genes 14 1.77e-01 2.09e-01 0.494000
Ca-dependent events 21 9.81e-02 -2.09e-01 0.395000
O-linked glycosylation 39 2.49e-02 -2.08e-01 0.240000
A tetrasaccharide linker sequence is required for GAG synthesis 10 2.56e-01 -2.07e-01 0.581000
RNA Polymerase II Transcription Termination 38 2.72e-02 2.07e-01 0.245000
Termination of O-glycan biosynthesis 10 2.57e-01 -2.07e-01 0.582000
Polymerase switching on the C-strand of the telomere 20 1.10e-01 2.07e-01 0.415000
Condensation of Prometaphase Chromosomes 10 2.63e-01 2.04e-01 0.586000
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.87e-01 2.04e-01 0.499000
PCNA-Dependent Long Patch Base Excision Repair 18 1.36e-01 2.03e-01 0.436000
Sema4D induced cell migration and growth-cone collapse 11 2.44e-01 2.03e-01 0.570000
Class B/2 (Secretin family receptors) 27 6.91e-02 -2.02e-01 0.343000
SRP-dependent cotranslational protein targeting to membrane 88 1.07e-03 2.02e-01 0.058200
G2/M DNA damage checkpoint 51 1.28e-02 2.02e-01 0.174000
CLEC7A (Dectin-1) induces NFAT activation 11 2.49e-01 2.01e-01 0.575000
AURKA Activation by TPX2 55 1.03e-02 2.00e-01 0.162000
CD28 dependent PI3K/Akt signaling 18 1.42e-01 2.00e-01 0.442000
mRNA 3’-end processing 30 5.85e-02 2.00e-01 0.323000
Disorders of Developmental Biology 10 2.75e-01 -1.99e-01 0.593000
Disorders of Nervous System Development 10 2.75e-01 -1.99e-01 0.593000
Loss of function of MECP2 in Rett syndrome 10 2.75e-01 -1.99e-01 0.593000
Pervasive developmental disorders 10 2.75e-01 -1.99e-01 0.593000
HDMs demethylate histones 15 1.84e-01 1.98e-01 0.497000
Eukaryotic Translation Termination 72 3.81e-03 1.97e-01 0.106000
TNFs bind their physiological receptors 10 2.80e-01 1.97e-01 0.602000
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 74 3.46e-03 1.97e-01 0.104000
Integrin signaling 16 1.73e-01 1.97e-01 0.490000
Platelet Aggregation (Plug Formation) 16 1.73e-01 1.97e-01 0.490000
Signaling by NOTCH4 67 5.55e-03 1.96e-01 0.120000
RHO GTPases Activate NADPH Oxidases 14 2.06e-01 -1.95e-01 0.521000
RNA polymerase II transcribes snRNA genes 66 6.14e-03 1.95e-01 0.128000
Regulation of IFNG signaling 13 2.23e-01 -1.95e-01 0.542000
Attenuation phase 19 1.42e-01 1.95e-01 0.442000
PLC beta mediated events 29 6.99e-02 -1.95e-01 0.343000
Cross-presentation of soluble exogenous antigens (endosomes) 37 4.15e-02 1.94e-01 0.281000
Diseases associated with N-glycosylation of proteins 18 1.55e-01 1.94e-01 0.460000
Formation of RNA Pol II elongation complex 46 2.42e-02 1.92e-01 0.238000
RNA Polymerase II Transcription Elongation 46 2.42e-02 1.92e-01 0.238000
TP53 Regulates Transcription of Cell Cycle Genes 40 3.55e-02 1.92e-01 0.265000
Formation of the ternary complex, and subsequently, the 43S complex 40 3.69e-02 1.91e-01 0.271000
Nuclear Pore Complex (NPC) Disassembly 33 5.96e-02 1.90e-01 0.324000
ROS and RNS production in phagocytes 23 1.18e-01 -1.88e-01 0.418000
HCMV Early Events 49 2.28e-02 1.88e-01 0.238000
FOXO-mediated transcription of cell cycle genes 12 2.59e-01 1.88e-01 0.584000
Formation of a pool of free 40S subunits 78 4.17e-03 1.88e-01 0.112000
Signaling by ALK 18 1.68e-01 1.88e-01 0.483000
Loss of Nlp from mitotic centrosomes 52 1.92e-02 1.88e-01 0.217000
Loss of proteins required for interphase microtubule organization from the centrosome 52 1.92e-02 1.88e-01 0.217000
Sema3A PAK dependent Axon repulsion 11 2.83e-01 -1.87e-01 0.605000
Transport of inorganic cations/anions and amino acids/oligopeptides 40 4.09e-02 -1.87e-01 0.281000
G alpha (i) signalling events 88 2.53e-03 -1.87e-01 0.086100
Methylation 10 3.07e-01 1.87e-01 0.628000
Constitutive Signaling by AKT1 E17K in Cancer 23 1.22e-01 1.87e-01 0.418000
Extension of Telomeres 41 3.91e-02 1.86e-01 0.281000
Cap-dependent Translation Initiation 95 1.74e-03 1.86e-01 0.073400
Eukaryotic Translation Initiation 95 1.74e-03 1.86e-01 0.073400
G alpha (s) signalling events 44 3.27e-02 -1.86e-01 0.258000
G-protein activation 12 2.64e-01 -1.86e-01 0.586000
Plasma lipoprotein assembly, remodeling, and clearance 38 4.71e-02 -1.86e-01 0.299000
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 8.92e-02 1.86e-01 0.375000
Peptide chain elongation 69 8.02e-03 1.85e-01 0.143000
Regulation of innate immune responses to cytosolic DNA 11 2.89e-01 -1.84e-01 0.607000
G2/M Checkpoints 108 9.62e-04 1.84e-01 0.054600
p53-Dependent G1 DNA Damage Response 55 1.82e-02 1.84e-01 0.217000
p53-Dependent G1/S DNA damage checkpoint 55 1.82e-02 1.84e-01 0.217000
Eukaryotic Translation Elongation 72 7.05e-03 1.84e-01 0.133000
Recycling pathway of L1 15 2.20e-01 -1.83e-01 0.541000
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 45 3.40e-02 1.83e-01 0.260000
HSF1-dependent transactivation 25 1.14e-01 1.83e-01 0.418000
MicroRNA (miRNA) biogenesis 18 1.81e-01 1.82e-01 0.497000
Sema4D in semaphorin signaling 13 2.55e-01 1.82e-01 0.581000
GPER1 signaling 24 1.23e-01 -1.82e-01 0.418000
Regulation of mRNA stability by proteins that bind AU-rich elements 74 6.97e-03 1.82e-01 0.133000
NOTCH3 Intracellular Domain Regulates Transcription 15 2.24e-01 1.81e-01 0.542000
G2/M Transition 147 1.66e-04 1.80e-01 0.016500
Translation initiation complex formation 47 3.38e-02 1.79e-01 0.260000
Transport of vitamins, nucleosides, and related molecules 21 1.56e-01 -1.79e-01 0.462000
CaM pathway 20 1.66e-01 -1.79e-01 0.480000
Calmodulin induced events 20 1.66e-01 -1.79e-01 0.480000
Notch-HLH transcription pathway 21 1.56e-01 1.79e-01 0.462000
Elastic fibre formation 16 2.17e-01 -1.78e-01 0.537000
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 1.16e-01 -1.78e-01 0.418000
VLDLR internalisation and degradation 11 3.07e-01 -1.78e-01 0.628000
Diseases associated with O-glycosylation of proteins 20 1.68e-01 -1.78e-01 0.484000
Influenza Viral RNA Transcription and Replication 112 1.18e-03 1.78e-01 0.060000
RHO GTPases Activate ROCKs 13 2.67e-01 1.78e-01 0.587000
Nuclear Envelope Breakdown 46 3.76e-02 1.77e-01 0.275000
GABA receptor activation 18 1.94e-01 -1.77e-01 0.505000
Protein-protein interactions at synapses 32 8.36e-02 -1.77e-01 0.375000
Regulation of PLK1 Activity at G2/M Transition 67 1.24e-02 1.77e-01 0.170000
MTOR signalling 32 8.38e-02 1.77e-01 0.375000
Mitochondrial tRNA aminoacylation 18 1.95e-01 1.77e-01 0.505000
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 51 2.94e-02 1.76e-01 0.247000
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 3.47e-02 1.76e-01 0.263000
HDR through Single Strand Annealing (SSA) 33 8.17e-02 1.75e-01 0.375000
Diseases of DNA repair 41 5.28e-02 1.75e-01 0.309000
L13a-mediated translational silencing of Ceruloplasmin expression 87 5.09e-03 1.74e-01 0.117000
ADORA2B mediated anti-inflammatory cytokines production 32 8.89e-02 -1.74e-01 0.375000
Stimuli-sensing channels 35 7.60e-02 -1.73e-01 0.362000
Presynaptic phase of homologous DNA pairing and strand exchange 32 8.99e-02 1.73e-01 0.375000
Collagen formation 19 1.91e-01 -1.73e-01 0.504000
Transport of the SLBP Dependant Mature mRNA 32 9.01e-02 1.73e-01 0.375000
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 15 2.46e-01 1.73e-01 0.572000
Purine ribonucleoside monophosphate biosynthesis 10 3.44e-01 1.73e-01 0.668000
Meiosis 39 6.23e-02 1.73e-01 0.329000
Transport of Mature mRNAs Derived from Intronless Transcripts 39 6.26e-02 1.72e-01 0.329000
Amyloid fiber formation 27 1.22e-01 -1.72e-01 0.418000
Mitotic G2-G2/M phases 149 3.02e-04 1.72e-01 0.024000
Cellular response to hypoxia 58 2.37e-02 1.72e-01 0.238000
Ubiquitin-dependent degradation of Cyclin D 43 5.14e-02 1.72e-01 0.305000
Aquaporin-mediated transport 24 1.46e-01 -1.72e-01 0.450000
VxPx cargo-targeting to cilium 16 2.35e-01 -1.72e-01 0.553000
Response of EIF2AK4 (GCN2) to amino acid deficiency 77 9.69e-03 1.71e-01 0.158000
ATF4 activates genes in response to endoplasmic reticulum stress 23 1.56e-01 1.71e-01 0.462000
Synthesis of PC 22 1.66e-01 1.71e-01 0.480000
Processive synthesis on the lagging strand 13 2.88e-01 1.70e-01 0.607000
Interleukin receptor SHC signaling 15 2.54e-01 1.70e-01 0.581000
Regulation of RUNX2 expression and activity 56 2.85e-02 1.69e-01 0.247000
Cell death signalling via NRAGE, NRIF and NADE 40 6.44e-02 -1.69e-01 0.332000
Telomere Maintenance 54 3.20e-02 1.69e-01 0.257000
RNA Polymerase III Transcription Initiation 35 8.41e-02 1.69e-01 0.375000
Vif-mediated degradation of APOBEC3G 42 5.90e-02 1.68e-01 0.324000
Selenocysteine synthesis 70 1.50e-02 1.68e-01 0.194000
G1/S DNA Damage Checkpoints 57 2.83e-02 1.68e-01 0.247000
Metabolism of cofactors 17 2.30e-01 1.68e-01 0.548000
GPCR ligand binding 75 1.22e-02 -1.68e-01 0.170000
GTP hydrolysis and joining of the 60S ribosomal subunit 88 6.66e-03 1.68e-01 0.133000
DNA strand elongation 27 1.32e-01 1.67e-01 0.436000
Translation of Structural Proteins 27 1.33e-01 1.67e-01 0.436000
Potential therapeutics for SARS 65 2.06e-02 1.66e-01 0.229000
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 33 9.98e-02 1.66e-01 0.398000
Diseases of DNA Double-Strand Break Repair 33 9.98e-02 1.66e-01 0.398000
Signaling by FGFR2 IIIa TM 15 2.67e-01 1.66e-01 0.587000
Cytosolic sulfonation of small molecules 10 3.67e-01 -1.65e-01 0.681000
Centrosome maturation 60 2.76e-02 1.65e-01 0.245000
Recruitment of mitotic centrosome proteins and complexes 60 2.76e-02 1.65e-01 0.245000
Chondroitin sulfate/dermatan sulfate metabolism 27 1.39e-01 -1.65e-01 0.436000
Ribosomal scanning and start codon recognition 47 5.12e-02 1.65e-01 0.305000
SUMOylation of ubiquitinylation proteins 36 8.78e-02 1.64e-01 0.375000
FGFR2 mutant receptor activation 16 2.55e-01 1.64e-01 0.581000
RNA Polymerase II Pre-transcription Events 64 2.34e-02 1.64e-01 0.238000
G-protein mediated events 32 1.09e-01 -1.64e-01 0.415000
AUF1 (hnRNP D0) binds and destabilizes mRNA 45 5.73e-02 1.64e-01 0.321000
Transport of Mature mRNA Derived from an Intronless Transcript 38 8.18e-02 1.63e-01 0.375000
Metabolic disorders of biological oxidation enzymes 14 2.90e-01 -1.63e-01 0.607000
Regulation of activated PAK-2p34 by proteasome mediated degradation 41 7.25e-02 1.62e-01 0.350000
Transport of the SLBP independent Mature mRNA 31 1.19e-01 1.62e-01 0.418000
Signaling by BMP 14 2.95e-01 -1.62e-01 0.614000
Azathioprine ADME 15 2.80e-01 1.61e-01 0.602000
Signaling by FGFR1 in disease 23 1.81e-01 -1.61e-01 0.497000
tRNA modification in the nucleus and cytosol 30 1.27e-01 1.61e-01 0.423000
The role of GTSE1 in G2/M progression after G2 checkpoint 51 4.79e-02 1.60e-01 0.299000
Role of LAT2/NTAL/LAB on calcium mobilization 10 3.80e-01 1.60e-01 0.701000
Activation of NF-kappaB in B cells 55 4.04e-02 1.60e-01 0.281000
CTLA4 inhibitory signaling 15 2.84e-01 1.60e-01 0.605000
SLC-mediated transmembrane transport 96 7.39e-03 -1.59e-01 0.136000
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 21 2.10e-01 1.58e-01 0.528000
Activation of GABAB receptors 17 2.61e-01 -1.58e-01 0.584000
GABA B receptor activation 17 2.61e-01 -1.58e-01 0.584000
Apoptotic cleavage of cellular proteins 24 1.82e-01 1.58e-01 0.497000
Anchoring of the basal body to the plasma membrane 74 1.93e-02 1.58e-01 0.217000
Interleukin-6 family signaling 13 3.26e-01 -1.57e-01 0.648000
Regulation of PTEN stability and activity 55 4.36e-02 1.57e-01 0.286000
TICAM1-dependent activation of IRF3/IRF7 12 3.46e-01 -1.57e-01 0.668000
Platelet calcium homeostasis 17 2.62e-01 -1.57e-01 0.585000
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 2.26e-01 1.56e-01 0.542000
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 3.11e-01 1.56e-01 0.632000
Formation of HIV elongation complex in the absence of HIV Tat 33 1.23e-01 1.55e-01 0.418000
RNA Polymerase I Transcription Termination 25 1.80e-01 1.55e-01 0.497000
Regulation of TP53 Activity through Phosphorylation 77 1.92e-02 1.55e-01 0.217000
Recruitment of NuMA to mitotic centrosomes 59 4.03e-02 1.54e-01 0.281000
RIP-mediated NFkB activation via ZBP1 13 3.35e-01 1.54e-01 0.660000
G beta:gamma signalling through PLC beta 12 3.55e-01 -1.54e-01 0.673000
Presynaptic function of Kainate receptors 12 3.55e-01 -1.54e-01 0.673000
Mitotic Prophase 72 2.41e-02 1.54e-01 0.238000
NOD1/2 Signaling Pathway 22 2.11e-01 1.54e-01 0.529000
Orc1 removal from chromatin 55 4.88e-02 1.54e-01 0.300000
FOXO-mediated transcription 45 7.68e-02 1.53e-01 0.362000
Degradation of GLI2 by the proteasome 49 6.50e-02 1.53e-01 0.332000
GLI3 is processed to GLI3R by the proteasome 49 6.50e-02 1.53e-01 0.332000
Influenza Infection 129 2.88e-03 1.52e-01 0.095400
G alpha (q) signalling events 74 2.38e-02 -1.52e-01 0.238000
Neurexins and neuroligins 21 2.28e-01 -1.52e-01 0.544000
Opioid Signalling 55 5.14e-02 -1.52e-01 0.305000
HCMV Infection 68 3.06e-02 1.52e-01 0.252000
Formation of HIV-1 elongation complex containing HIV-1 Tat 32 1.38e-01 1.52e-01 0.436000
HIV Transcription Elongation 32 1.38e-01 1.52e-01 0.436000
Tat-mediated elongation of the HIV-1 transcript 32 1.38e-01 1.52e-01 0.436000
Complex I biogenesis 40 9.81e-02 1.51e-01 0.395000
Inwardly rectifying K+ channels 12 3.65e-01 -1.51e-01 0.681000
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 8.73e-02 1.51e-01 0.375000
p53-Independent DNA Damage Response 43 8.73e-02 1.51e-01 0.375000
p53-Independent G1/S DNA damage checkpoint 43 8.73e-02 1.51e-01 0.375000
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 3.67e-01 1.51e-01 0.681000
Interleukin-12 signaling 35 1.24e-01 1.50e-01 0.418000
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 45 8.11e-02 1.50e-01 0.375000
Nucleotide biosynthesis 12 3.68e-01 1.50e-01 0.681000
Cargo concentration in the ER 19 2.59e-01 -1.50e-01 0.584000
Downstream TCR signaling 69 3.21e-02 1.49e-01 0.257000
Nucleotide catabolism 20 2.48e-01 1.49e-01 0.574000
Sulfur amino acid metabolism 17 2.87e-01 -1.49e-01 0.607000
SUMOylation of SUMOylation proteins 31 1.53e-01 1.48e-01 0.460000
Branched-chain amino acid catabolism 20 2.51e-01 -1.48e-01 0.578000
RHOQ GTPase cycle 36 1.24e-01 -1.48e-01 0.418000
RNA Polymerase III Abortive And Retractive Initiation 39 1.10e-01 1.48e-01 0.415000
RNA Polymerase III Transcription 39 1.10e-01 1.48e-01 0.415000
Listeria monocytogenes entry into host cells 14 3.38e-01 -1.48e-01 0.663000
Activated NOTCH1 Transmits Signal to the Nucleus 19 2.66e-01 -1.47e-01 0.587000
O-linked glycosylation of mucins 26 1.95e-01 -1.47e-01 0.505000
BMAL1:CLOCK,NPAS2 activates circadian gene expression 15 3.25e-01 1.47e-01 0.648000
Vpu mediated degradation of CD4 43 9.61e-02 1.47e-01 0.390000
Platelet homeostasis 47 8.24e-02 -1.47e-01 0.375000
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 4.00e-01 1.47e-01 0.722000
Activation of the pre-replicative complex 23 2.26e-01 1.46e-01 0.542000
Condensation of Prophase Chromosomes 12 3.82e-01 1.46e-01 0.703000
Selenoamino acid metabolism 78 2.65e-02 1.45e-01 0.245000
XBP1(S) activates chaperone genes 39 1.17e-01 1.45e-01 0.418000
Formation of the Early Elongation Complex 26 2.01e-01 1.45e-01 0.517000
Formation of the HIV-1 Early Elongation Complex 26 2.01e-01 1.45e-01 0.517000
Homologous DNA Pairing and Strand Exchange 35 1.39e-01 1.45e-01 0.436000
Transcription of the HIV genome 53 6.90e-02 1.45e-01 0.343000
Signaling by FGFR4 24 2.21e-01 -1.44e-01 0.541000
RHO GTPases activate PAKs 13 3.68e-01 1.44e-01 0.681000
Activation of G protein gated Potassium channels 11 4.08e-01 -1.44e-01 0.729000
G protein gated Potassium channels 11 4.08e-01 -1.44e-01 0.729000
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 4.08e-01 -1.44e-01 0.729000
PERK regulates gene expression 26 2.04e-01 1.44e-01 0.520000
Gene Silencing by RNA 57 6.02e-02 1.44e-01 0.326000
Negative regulation of MET activity 16 3.19e-01 -1.44e-01 0.641000
SARS-CoV Infections 263 6.59e-05 1.44e-01 0.009350
Downstream signaling events of B Cell Receptor (BCR) 68 4.07e-02 1.44e-01 0.281000
Heme signaling 26 2.05e-01 -1.44e-01 0.521000
HIV Transcription Initiation 39 1.21e-01 1.44e-01 0.418000
RNA Polymerase II HIV Promoter Escape 39 1.21e-01 1.44e-01 0.418000
RNA Polymerase II Promoter Escape 39 1.21e-01 1.44e-01 0.418000
RNA Polymerase II Transcription Initiation 39 1.21e-01 1.44e-01 0.418000
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 1.21e-01 1.44e-01 0.418000
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 1.21e-01 1.44e-01 0.418000
Chromatin modifying enzymes 142 3.25e-03 1.43e-01 0.102000
Chromatin organization 142 3.25e-03 1.43e-01 0.102000
Late endosomal microautophagy 21 2.56e-01 -1.43e-01 0.581000
ER-Phagosome pathway 67 4.29e-02 1.43e-01 0.286000
Erythropoietin activates RAS 10 4.33e-01 -1.43e-01 0.754000
MAPK6/MAPK4 signaling 65 4.61e-02 1.43e-01 0.295000
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 3.91e-01 -1.43e-01 0.715000
G1/S Transition 106 1.14e-02 1.43e-01 0.168000
Synthesis of very long-chain fatty acyl-CoAs 12 3.93e-01 1.42e-01 0.717000
Bile acid and bile salt metabolism 14 3.57e-01 -1.42e-01 0.673000
Regulation of signaling by CBL 14 3.58e-01 1.42e-01 0.673000
N-Glycan antennae elongation 11 4.15e-01 -1.42e-01 0.738000
Telomere C-strand (Lagging Strand) Synthesis 27 2.03e-01 1.41e-01 0.520000
Sphingolipid de novo biosynthesis 18 2.99e-01 1.41e-01 0.621000
Peptide ligand-binding receptors 19 2.88e-01 -1.41e-01 0.607000
PIWI-interacting RNA (piRNA) biogenesis 15 3.46e-01 1.41e-01 0.668000
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 3.99e-01 -1.41e-01 0.722000
Trafficking of AMPA receptors 12 3.99e-01 -1.41e-01 0.722000
FCGR3A-mediated IL10 synthesis 22 2.54e-01 -1.41e-01 0.581000
RHOC GTPase cycle 45 1.03e-01 1.41e-01 0.406000
Signaling by FGFR3 25 2.25e-01 -1.40e-01 0.542000
IRE1alpha activates chaperones 40 1.27e-01 1.40e-01 0.423000
Signalling to RAS 12 4.03e-01 1.39e-01 0.726000
Prostacyclin signalling through prostacyclin receptor 11 4.24e-01 -1.39e-01 0.748000
PI3K/AKT Signaling in Cancer 51 8.60e-02 1.39e-01 0.375000
Energy dependent regulation of mTOR by LKB1-AMPK 21 2.71e-01 1.39e-01 0.592000
Polo-like kinase mediated events 16 3.37e-01 1.39e-01 0.662000
Caspase activation via extrinsic apoptotic signalling pathway 15 3.53e-01 1.38e-01 0.672000
Interleukin-12 family signaling 41 1.27e-01 1.38e-01 0.423000
Degradation of DVL 47 1.03e-01 1.37e-01 0.406000
Interleukin-4 and Interleukin-13 signaling 48 1.00e-01 1.37e-01 0.398000
Inhibition of DNA recombination at telomere 18 3.14e-01 1.37e-01 0.635000
SCF-beta-TrCP mediated degradation of Emi1 46 1.08e-01 1.37e-01 0.415000
Inactivation of CSF3 (G-CSF) signaling 20 2.89e-01 -1.37e-01 0.607000
Binding and Uptake of Ligands by Scavenger Receptors 10 4.53e-01 1.37e-01 0.776000
Unfolded Protein Response (UPR) 72 4.50e-02 1.37e-01 0.292000
Interactions of Vpr with host cellular proteins 32 1.81e-01 1.37e-01 0.497000
mRNA Splicing - Major Pathway 131 7.13e-03 1.37e-01 0.133000
Vasopressin regulates renal water homeostasis via Aquaporins 22 2.68e-01 -1.36e-01 0.588000
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 3.99e-01 -1.35e-01 0.722000
Other interleukin signaling 16 3.51e-01 -1.35e-01 0.672000
rRNA modification in the nucleus and cytosol 46 1.15e-01 1.35e-01 0.418000
PTEN Regulation 107 1.66e-02 1.34e-01 0.210000
Transcriptional regulation by RUNX3 73 4.86e-02 1.34e-01 0.300000
TNFR2 non-canonical NF-kB pathway 66 6.22e-02 1.33e-01 0.329000
Transport of Mature Transcript to Cytoplasm 56 8.60e-02 1.33e-01 0.375000
Cyclin A:Cdk2-associated events at S phase entry 72 5.19e-02 1.33e-01 0.305000
Formation of the beta-catenin:TCF transactivating complex 24 2.62e-01 1.32e-01 0.584000
Signaling by ROBO receptors 151 5.38e-03 1.32e-01 0.120000
Signaling by ALK fusions and activated point mutants 43 1.36e-01 1.32e-01 0.436000
Signaling by ALK in cancer 43 1.36e-01 1.32e-01 0.436000
Nicotinate metabolism 16 3.63e-01 1.31e-01 0.680000
Platelet sensitization by LDL 13 4.12e-01 1.31e-01 0.735000
Mitochondrial protein import 42 1.42e-01 1.31e-01 0.442000
ABC transporters in lipid homeostasis 10 4.73e-01 1.31e-01 0.793000
S Phase 129 1.04e-02 1.31e-01 0.162000
RAF-independent MAPK1/3 activation 20 3.11e-01 -1.31e-01 0.632000
Gap-filling DNA repair synthesis and ligation in TC-NER 55 9.40e-02 1.31e-01 0.385000
Cell Cycle 492 1.05e-06 1.30e-01 0.000823
Cell Cycle Checkpoints 212 1.21e-03 1.30e-01 0.060000
p75 NTR receptor-mediated signalling 54 9.98e-02 -1.30e-01 0.398000
Mismatch Repair 13 4.19e-01 1.29e-01 0.742000
Antigen processing-Cross presentation 72 5.82e-02 1.29e-01 0.323000
Host Interactions of HIV factors 104 2.30e-02 1.29e-01 0.238000
TCR signaling 84 4.15e-02 1.29e-01 0.281000
Interleukin-2 family signaling 28 2.39e-01 1.29e-01 0.561000
Defective CFTR causes cystic fibrosis 51 1.14e-01 1.28e-01 0.418000
Constitutive Signaling by EGFRvIII 10 4.85e-01 1.28e-01 0.800000
Signaling by EGFRvIII in Cancer 10 4.85e-01 1.28e-01 0.800000
NIK–>noncanonical NF-kB signaling 49 1.25e-01 1.27e-01 0.418000
FCERI mediated NF-kB activation 61 8.68e-02 1.27e-01 0.375000
Class A/1 (Rhodopsin-like receptors) 46 1.38e-01 -1.27e-01 0.436000
SARS-CoV-2 Infection 207 1.79e-03 1.27e-01 0.073400
TRAF6 mediated NF-kB activation 19 3.40e-01 1.26e-01 0.666000
Interferon alpha/beta signaling 50 1.23e-01 1.26e-01 0.418000
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 60 9.21e-02 1.26e-01 0.381000
RNA Polymerase I Transcription Initiation 40 1.70e-01 1.26e-01 0.485000
Mitotic Prometaphase 150 8.35e-03 1.25e-01 0.144000
APC/C-mediated degradation of cell cycle proteins 73 6.51e-02 1.25e-01 0.332000
Regulation of mitotic cell cycle 73 6.51e-02 1.25e-01 0.332000
Regulation of RUNX3 expression and activity 48 1.35e-01 1.25e-01 0.436000
Chaperone Mediated Autophagy 12 4.55e-01 -1.24e-01 0.778000
Activation of BH3-only proteins 25 2.82e-01 1.24e-01 0.605000
M Phase 280 3.80e-04 1.24e-01 0.026600
Regulation of Apoptosis 44 1.54e-01 1.24e-01 0.460000
DAP12 signaling 19 3.50e-01 1.24e-01 0.672000
APC-Cdc20 mediated degradation of Nek2A 21 3.26e-01 -1.24e-01 0.648000
TNFR1-induced proapoptotic signaling 12 4.58e-01 1.24e-01 0.780000
mRNA Splicing 141 1.21e-02 1.23e-01 0.170000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 5.02e-01 -1.23e-01 0.808000
alpha-linolenic acid (ALA) metabolism 10 5.02e-01 -1.23e-01 0.808000
GPCR downstream signalling 185 4.21e-03 -1.23e-01 0.112000
TBC/RABGAPs 39 1.87e-01 1.22e-01 0.499000
NRAGE signals death through JNK 25 2.90e-01 -1.22e-01 0.607000
Cyclin E associated events during G1/S transition 70 7.78e-02 1.22e-01 0.365000
Interleukin-20 family signaling 13 4.46e-01 -1.22e-01 0.767000
ZBP1(DAI) mediated induction of type I IFNs 16 3.99e-01 1.22e-01 0.722000
Hh mutants are degraded by ERAD 46 1.53e-01 1.22e-01 0.460000
Cholesterol biosynthesis 20 3.47e-01 -1.21e-01 0.668000
Cellular response to starvation 112 2.69e-02 1.21e-01 0.245000
Vpr-mediated nuclear import of PICs 31 2.43e-01 1.21e-01 0.569000
TP53 Regulates Transcription of DNA Repair Genes 47 1.51e-01 1.21e-01 0.456000
SARS-CoV-1 Infection 44 1.65e-01 1.21e-01 0.480000
RHOF GTPase cycle 23 3.15e-01 1.21e-01 0.635000
SCF(Skp2)-mediated degradation of p27/p21 51 1.36e-01 1.21e-01 0.436000
tRNA processing 87 5.20e-02 1.21e-01 0.305000
Intraflagellar transport 31 2.45e-01 1.21e-01 0.571000
Metabolism of RNA 521 3.30e-06 1.21e-01 0.000982
Processing of Capped Intron-Containing Pre-mRNA 181 5.72e-03 1.20e-01 0.122000
Mitochondrial iron-sulfur cluster biogenesis 12 4.74e-01 1.19e-01 0.793000
Transport of Mature mRNA derived from an Intron-Containing Transcript 47 1.57e-01 1.19e-01 0.462000
RHOB GTPase cycle 40 1.92e-01 1.19e-01 0.504000
Elevation of cytosolic Ca2+ levels 10 5.16e-01 -1.19e-01 0.816000
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 3.26e-01 -1.18e-01 0.648000
Reproduction 43 1.82e-01 1.18e-01 0.497000
Signal transduction by L1 11 4.99e-01 -1.18e-01 0.808000
Resolution of Sister Chromatid Cohesion 90 5.48e-02 1.17e-01 0.312000
Cell Cycle, Mitotic 398 7.06e-05 1.17e-01 0.009350
Cardiac conduction 42 1.92e-01 -1.16e-01 0.504000
Signal amplification 19 3.80e-01 -1.16e-01 0.701000
PIP3 activates AKT signaling 175 8.24e-03 1.16e-01 0.144000
Sensory processing of sound by outer hair cells of the cochlea 16 4.21e-01 1.16e-01 0.745000
Translation 237 2.20e-03 1.16e-01 0.081900
Budding and maturation of HIV virion 22 3.47e-01 -1.16e-01 0.668000
Viral Messenger RNA Synthesis 40 2.05e-01 1.16e-01 0.521000
Signaling by GPCR 202 4.79e-03 -1.16e-01 0.117000
APC/C:Cdc20 mediated degradation of mitotic proteins 61 1.20e-01 1.15e-01 0.418000
Diseases associated with glycosaminoglycan metabolism 16 4.26e-01 -1.15e-01 0.748000
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 27 3.02e-01 1.15e-01 0.623000
Regulation of Glucokinase by Glucokinase Regulatory Protein 27 3.02e-01 1.15e-01 0.623000
Chromosome Maintenance 72 9.56e-02 1.14e-01 0.389000
Infectious disease 611 2.34e-06 1.14e-01 0.000930
Metabolism of non-coding RNA 46 1.84e-01 1.13e-01 0.497000
snRNP Assembly 46 1.84e-01 1.13e-01 0.497000
Anti-inflammatory response favouring Leishmania parasite infection 53 1.54e-01 -1.13e-01 0.460000
Leishmania parasite growth and survival 53 1.54e-01 -1.13e-01 0.460000
Regulation of RAS by GAPs 55 1.47e-01 1.13e-01 0.451000
Glucagon-type ligand receptors 13 4.80e-01 -1.13e-01 0.798000
Mitotic G1 phase and G1/S transition 121 3.24e-02 1.13e-01 0.257000
Autodegradation of Cdh1 by Cdh1:APC/C 52 1.61e-01 1.13e-01 0.471000
NEP/NS2 Interacts with the Cellular Export Machinery 29 2.96e-01 1.12e-01 0.617000
Transport of bile salts and organic acids, metal ions and amine compounds 32 2.73e-01 -1.12e-01 0.593000
tRNA Aminoacylation 23 3.53e-01 1.12e-01 0.672000
L1CAM interactions 40 2.21e-01 -1.12e-01 0.541000
Defects in vitamin and cofactor metabolism 16 4.39e-01 1.12e-01 0.760000
RIPK1-mediated regulated necrosis 25 3.34e-01 1.12e-01 0.659000
Regulation of necroptotic cell death 25 3.34e-01 1.12e-01 0.659000
RHOD GTPase cycle 33 2.67e-01 1.12e-01 0.587000
Cytoprotection by HMOX1 42 2.12e-01 -1.11e-01 0.530000
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 3.00e-01 1.11e-01 0.622000
Dectin-1 mediated noncanonical NF-kB signaling 50 1.75e-01 1.11e-01 0.491000
Signaling by FGFR1 27 3.19e-01 -1.11e-01 0.641000
Estrogen-dependent gene expression 68 1.16e-01 1.10e-01 0.418000
UCH proteinases 72 1.07e-01 1.10e-01 0.415000
Costimulation by the CD28 family 44 2.08e-01 1.10e-01 0.523000
Signaling by the B Cell Receptor (BCR) 88 7.62e-02 1.10e-01 0.362000
Nuclear events mediated by NFE2L2 66 1.25e-01 1.09e-01 0.418000
CD209 (DC-SIGN) signaling 15 4.63e-01 -1.09e-01 0.786000
Mitotic Metaphase and Anaphase 186 1.05e-02 1.09e-01 0.162000
Post-translational modification: synthesis of GPI-anchored proteins 30 3.01e-01 -1.09e-01 0.623000
ABC-family proteins mediated transport 72 1.10e-01 1.09e-01 0.415000
Synthesis of DNA 95 6.71e-02 1.09e-01 0.341000
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 59 1.49e-01 1.09e-01 0.454000
SARS-CoV-2-host interactions 146 2.38e-02 1.09e-01 0.238000
Separation of Sister Chromatids 141 2.64e-02 1.09e-01 0.245000
ECM proteoglycans 11 5.33e-01 -1.08e-01 0.829000
Mitotic Anaphase 185 1.18e-02 1.08e-01 0.170000
tRNA processing in the nucleus 53 1.75e-01 1.08e-01 0.491000
SUMOylation of DNA methylation proteins 14 4.85e-01 -1.08e-01 0.800000
Interleukin-10 signaling 13 5.01e-01 -1.08e-01 0.808000
rRNA processing in the nucleus and cytosol 156 2.11e-02 1.07e-01 0.229000
Signaling by ERBB2 TMD/JMD mutants 10 5.57e-01 -1.07e-01 0.840000
Export of Viral Ribonucleoproteins from Nucleus 30 3.09e-01 1.07e-01 0.632000
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 62 1.45e-01 1.07e-01 0.450000
Transcriptional regulation by small RNAs 42 2.31e-01 1.07e-01 0.548000
Regulation of TP53 Activity 133 3.41e-02 1.07e-01 0.260000
NS1 Mediated Effects on Host Pathways 37 2.62e-01 1.07e-01 0.584000
DAG and IP3 signaling 26 3.47e-01 -1.07e-01 0.668000
FGFR2 alternative splicing 22 3.87e-01 1.07e-01 0.710000
Deadenylation-dependent mRNA decay 50 1.94e-01 1.06e-01 0.505000
RHOU GTPase cycle 29 3.22e-01 1.06e-01 0.645000
Dual incision in TC-NER 56 1.72e-01 1.06e-01 0.489000
Downregulation of ERBB2 signaling 17 4.53e-01 -1.05e-01 0.776000
KEAP1-NFE2L2 pathway 85 9.42e-02 1.05e-01 0.385000
Signaling by EGFR 35 2.83e-01 1.05e-01 0.605000
Removal of the Flap Intermediate from the C-strand 15 4.83e-01 1.05e-01 0.799000
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 58 1.69e-01 1.05e-01 0.484000
Degradation of GLI1 by the proteasome 50 2.02e-01 1.04e-01 0.518000
APC/C:Cdc20 mediated degradation of Securin 54 1.86e-01 1.04e-01 0.499000
Insulin receptor recycling 17 4.59e-01 -1.04e-01 0.781000
Hh mutants abrogate ligand secretion 48 2.15e-01 1.04e-01 0.535000
Major pathway of rRNA processing in the nucleolus and cytosol 150 2.91e-02 1.04e-01 0.247000
HCMV Late Events 48 2.15e-01 1.03e-01 0.535000
DNA Replication Pre-Initiation 79 1.13e-01 1.03e-01 0.418000
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 5.36e-01 1.03e-01 0.829000
Post-chaperonin tubulin folding pathway 12 5.38e-01 1.03e-01 0.830000
Mitochondrial calcium ion transport 14 5.07e-01 1.02e-01 0.809000
Integrin cell surface interactions 24 3.85e-01 1.02e-01 0.708000
FGFR1 mutant receptor activation 19 4.40e-01 -1.02e-01 0.761000
Nuclear Envelope (NE) Reassembly 56 1.86e-01 1.02e-01 0.499000
NoRC negatively regulates rRNA expression 42 2.54e-01 1.02e-01 0.581000
Cellular responses to stress 519 9.53e-05 1.01e-01 0.011400
Glycogen synthesis 11 5.60e-01 -1.01e-01 0.840000
CLEC7A (Dectin-1) signaling 81 1.15e-01 1.01e-01 0.418000
Transferrin endocytosis and recycling 19 4.44e-01 -1.01e-01 0.765000
Fatty acid metabolism 97 8.57e-02 -1.01e-01 0.375000
Homology Directed Repair 84 1.10e-01 1.01e-01 0.415000
CDK-mediated phosphorylation and removal of Cdc6 58 1.84e-01 1.01e-01 0.497000
Inactivation of APC/C via direct inhibition of the APC/C complex 16 4.88e-01 -1.00e-01 0.802000
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 16 4.88e-01 -1.00e-01 0.802000
rRNA processing 160 3.01e-02 9.97e-02 0.249000
Cellular Senescence 99 8.79e-02 9.95e-02 0.375000
Hedgehog ligand biogenesis 51 2.20e-01 9.95e-02 0.541000
Nuclear events stimulated by ALK signaling in cancer 13 5.36e-01 9.90e-02 0.829000
Metalloprotease DUBs 16 4.93e-01 -9.89e-02 0.807000
Regulation of APC/C activators between G1/S and early anaphase 66 1.66e-01 9.87e-02 0.480000
Degradation of AXIN 46 2.48e-01 9.85e-02 0.575000
ABC transporter disorders 58 1.96e-01 9.83e-02 0.506000
Insulin processing 15 5.11e-01 9.81e-02 0.810000
Inactivation, recovery and regulation of the phototransduction cascade 16 5.02e-01 9.70e-02 0.808000
The phototransduction cascade 16 5.02e-01 9.70e-02 0.808000
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 5.61e-01 9.69e-02 0.840000
HIV Infection 182 2.47e-02 9.69e-02 0.240000
Cellular responses to stimuli 524 1.90e-04 9.66e-02 0.017400
Switching of origins to a post-replicative state 71 1.60e-01 9.65e-02 0.471000
Cargo recognition for clathrin-mediated endocytosis 64 1.84e-01 -9.61e-02 0.497000
Processing of DNA double-strand break ends 52 2.31e-01 9.61e-02 0.548000
GAB1 signalosome 10 5.99e-01 9.60e-02 0.850000
Neddylation 183 2.58e-02 9.59e-02 0.244000
RET signaling 23 4.26e-01 -9.59e-02 0.748000
Intra-Golgi traffic 38 3.07e-01 9.58e-02 0.628000
Collagen biosynthesis and modifying enzymes 13 5.51e-01 -9.55e-02 0.838000
Cell-Cell communication 44 2.75e-01 -9.52e-02 0.593000
mTORC1-mediated signalling 17 4.98e-01 9.49e-02 0.808000
Ion homeostasis 26 4.03e-01 -9.47e-02 0.726000
Regulation of PTEN gene transcription 44 2.84e-01 9.35e-02 0.605000
Ephrin signaling 12 5.75e-01 -9.35e-02 0.842000
MAP3K8 (TPL2)-dependent MAPK1/3 activation 13 5.60e-01 -9.34e-02 0.840000
HDR through Homologous Recombination (HRR) 55 2.32e-01 9.33e-02 0.549000
Golgi-to-ER retrograde transport 94 1.19e-01 9.32e-02 0.418000
Synthesis of bile acids and bile salts 13 5.62e-01 -9.29e-02 0.840000
Signaling by cytosolic FGFR1 fusion mutants 16 5.25e-01 -9.19e-02 0.826000
EML4 and NUDC in mitotic spindle formation 85 1.47e-01 9.12e-02 0.451000
FCGR3A-mediated phagocytosis 41 3.15e-01 9.07e-02 0.635000
Leishmania phagocytosis 41 3.15e-01 9.07e-02 0.635000
Parasite infection 41 3.15e-01 9.07e-02 0.635000
Myogenesis 13 5.72e-01 9.05e-02 0.842000
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 5.58e-01 -9.04e-02 0.840000
Intracellular signaling by second messengers 200 2.92e-02 8.99e-02 0.247000
Regulation of TP53 Expression and Degradation 34 3.65e-01 8.99e-02 0.681000
Synthesis of PIPs at the Golgi membrane 12 5.90e-01 8.98e-02 0.847000
DNA Replication 102 1.18e-01 8.97e-02 0.418000
Unwinding of DNA 10 6.24e-01 8.96e-02 0.864000
Signaling by Insulin receptor 41 3.21e-01 -8.95e-02 0.644000
Beta-catenin phosphorylation cascade 15 5.48e-01 -8.95e-02 0.838000
Transcription of E2F targets under negative control by DREAM complex 17 5.25e-01 -8.90e-02 0.826000
Cilium Assembly 140 6.98e-02 8.90e-02 0.343000
RHOBTB2 GTPase cycle 20 4.92e-01 8.87e-02 0.806000
Metabolism of nitric oxide: NOS3 activation and regulation 12 5.95e-01 8.87e-02 0.849000
CD28 co-stimulation 27 4.27e-01 8.83e-02 0.749000
G beta:gamma signalling through BTK 10 6.31e-01 -8.78e-02 0.864000
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 76 1.87e-01 8.77e-02 0.499000
Diseases of programmed cell death 37 3.56e-01 8.77e-02 0.673000
RUNX3 regulates p14-ARF 10 6.32e-01 -8.75e-02 0.864000
Infection with Mycobacterium tuberculosis 22 4.78e-01 -8.73e-02 0.798000
RUNX1 regulates transcription of genes involved in differentiation of HSCs 55 2.68e-01 8.65e-02 0.587000
TRAF3-dependent IRF activation pathway 14 5.76e-01 -8.64e-02 0.842000
RAB geranylgeranylation 39 3.51e-01 -8.63e-02 0.672000
Glycogen metabolism 17 5.41e-01 -8.57e-02 0.832000
RHO GTPases Activate WASPs and WAVEs 28 4.34e-01 8.55e-02 0.754000
Fanconi Anemia Pathway 29 4.26e-01 -8.55e-02 0.748000
Nucleotide salvage 18 5.33e-01 -8.49e-02 0.829000
FLT3 Signaling 32 4.07e-01 8.47e-02 0.729000
Gamma carboxylation, hypusine formation and arylsulfatase activation 21 5.02e-01 8.47e-02 0.808000
Citric acid cycle (TCA cycle) 19 5.23e-01 8.46e-02 0.826000
Insulin receptor signalling cascade 25 4.64e-01 -8.45e-02 0.786000
Interleukin-1 signaling 75 2.07e-01 8.45e-02 0.521000
Base Excision Repair 39 3.65e-01 8.39e-02 0.681000
Ion channel transport 76 2.07e-01 -8.39e-02 0.521000
Collagen degradation 10 6.47e-01 8.35e-02 0.870000
Organelle biogenesis and maintenance 193 4.70e-02 8.33e-02 0.299000
Resolution of Abasic Sites (AP sites) 32 4.15e-01 8.32e-02 0.738000
Peptide hormone metabolism 28 4.46e-01 8.32e-02 0.767000
COPI-mediated anterograde transport 69 2.33e-01 8.32e-02 0.550000
Apoptotic execution phase 32 4.16e-01 8.31e-02 0.738000
Regulation of actin dynamics for phagocytic cup formation 43 3.52e-01 8.21e-02 0.672000
Uptake and actions of bacterial toxins 18 5.47e-01 -8.20e-02 0.838000
Signaling by CSF3 (G-CSF) 25 4.79e-01 -8.19e-02 0.798000
Sphingolipid metabolism 43 3.54e-01 8.18e-02 0.672000
SUMOylation of DNA replication proteins 42 3.60e-01 8.17e-02 0.675000
Diseases of metabolism 125 1.17e-01 -8.14e-02 0.418000
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 5.85e-01 8.14e-02 0.847000
Protein localization 115 1.33e-01 8.13e-02 0.436000
Base-Excision Repair, AP Site Formation 16 5.74e-01 -8.13e-02 0.842000
mRNA Splicing - Minor Pathway 45 3.47e-01 8.11e-02 0.668000
Intra-Golgi and retrograde Golgi-to-ER traffic 155 8.35e-02 8.08e-02 0.375000
RHO GTPases Activate Formins 100 1.64e-01 8.08e-02 0.478000
G0 and Early G1 24 4.95e-01 -8.05e-02 0.808000
Gap-filling DNA repair synthesis and ligation in GG-NER 23 5.04e-01 8.05e-02 0.809000
RNA Polymerase III Chain Elongation 17 5.66e-01 8.04e-02 0.840000
RHOV GTPase cycle 27 4.72e-01 8.00e-02 0.792000
Apoptosis 129 1.19e-01 7.97e-02 0.418000
Transport of Ribonucleoproteins into the Host Nucleus 29 4.58e-01 7.96e-02 0.780000
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 78 2.25e-01 7.96e-02 0.542000
Regulation of TP53 Degradation 33 4.30e-01 7.94e-02 0.751000
Assembly of the pre-replicative complex 66 2.66e-01 7.92e-02 0.587000
RAF/MAP kinase cascade 152 9.30e-02 7.92e-02 0.384000
FCERI mediated Ca+2 mobilization 23 5.12e-01 7.90e-02 0.810000
Disease 1053 2.66e-05 7.88e-02 0.005290
Basigin interactions 14 6.10e-01 7.87e-02 0.860000
Sialic acid metabolism 22 5.24e-01 -7.86e-02 0.826000
Suppression of phagosomal maturation 12 6.38e-01 -7.85e-02 0.865000
MAPK family signaling cascades 181 7.00e-02 7.84e-02 0.343000
Fatty acyl-CoA biosynthesis 22 5.27e-01 7.80e-02 0.826000
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 81 2.26e-01 7.79e-02 0.542000
Amplification of signal from the kinetochores 81 2.26e-01 7.79e-02 0.542000
Signaling by MET 40 3.95e-01 -7.78e-02 0.720000
Regulation of TP53 Activity through Methylation 16 5.91e-01 7.77e-02 0.847000
Fc epsilon receptor (FCERI) signaling 103 1.75e-01 7.75e-02 0.491000
Sealing of the nuclear envelope (NE) by ESCRT-III 16 5.92e-01 7.75e-02 0.848000
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 18 5.71e-01 7.72e-02 0.842000
Diseases of glycosylation 68 2.72e-01 -7.71e-02 0.593000
Plasma lipoprotein remodeling 11 6.59e-01 -7.68e-02 0.876000
Respiratory electron transport 75 2.51e-01 7.68e-02 0.578000
Asymmetric localization of PCP proteins 51 3.43e-01 7.68e-02 0.668000
Iron uptake and transport 38 4.13e-01 -7.67e-02 0.736000
Transcriptional Regulation by TP53 280 2.91e-02 7.63e-02 0.247000
Diseases of signal transduction by growth factor receptors and second messengers 293 2.61e-02 7.61e-02 0.245000
Processive synthesis on the C-strand of the telomere 17 5.88e-01 7.59e-02 0.847000
Response of Mtb to phagocytosis 20 5.58e-01 -7.57e-02 0.840000
HIV elongation arrest and recovery 23 5.30e-01 7.56e-02 0.829000
Pausing and recovery of HIV elongation 23 5.30e-01 7.56e-02 0.829000
Cytokine Signaling in Immune system 416 8.90e-03 7.55e-02 0.147000
Prolonged ERK activation events 13 6.37e-01 -7.55e-02 0.865000
Ca2+ pathway 36 4.34e-01 -7.54e-02 0.754000
MAPK1/MAPK3 signaling 157 1.05e-01 7.53e-02 0.409000
APC/C:Cdc20 mediated degradation of Cyclin B 19 5.70e-01 -7.52e-02 0.842000
Recognition of DNA damage by PCNA-containing replication complex 26 5.07e-01 7.52e-02 0.809000
SUMO E3 ligases SUMOylate target proteins 131 1.39e-01 7.51e-02 0.436000
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 6.16e-01 7.48e-02 0.864000
Death Receptor Signalling 88 2.26e-01 -7.48e-02 0.542000
Abortive elongation of HIV-1 transcript in the absence of Tat 18 5.84e-01 7.45e-02 0.847000
DNA Double-Strand Break Repair 109 1.82e-01 7.42e-02 0.497000
Signaling by ERBB2 KD Mutants 12 6.57e-01 -7.40e-02 0.875000
Clathrin-mediated endocytosis 89 2.29e-01 -7.40e-02 0.545000
Cleavage of the damaged pyrimidine 14 6.33e-01 -7.36e-02 0.864000
Depyrimidination 14 6.33e-01 -7.36e-02 0.864000
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 6.33e-01 -7.36e-02 0.864000
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 10 6.88e-01 7.33e-02 0.891000
Disorders of transmembrane transporters 107 1.92e-01 7.32e-02 0.504000
Circadian Clock 51 3.68e-01 -7.29e-02 0.681000
RHOG GTPase cycle 45 3.99e-01 -7.28e-02 0.722000
Degradation of beta-catenin by the destruction complex 67 3.04e-01 7.27e-02 0.625000
Glyoxylate metabolism and glycine degradation 19 5.84e-01 -7.27e-02 0.847000
Metabolism of nucleotides 68 3.04e-01 7.22e-02 0.625000
Fcgamma receptor (FCGR) dependent phagocytosis 61 3.36e-01 7.14e-02 0.660000
Frs2-mediated activation 11 6.82e-01 7.13e-02 0.891000
Signaling by NOTCH3 30 5.00e-01 7.11e-02 0.808000
Metabolism of carbohydrates 178 1.04e-01 -7.10e-02 0.407000
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 22 5.66e-01 7.07e-02 0.840000
Aggrephagy 19 5.94e-01 -7.07e-02 0.849000
Constitutive Signaling by Aberrant PI3K in Cancer 27 5.26e-01 7.05e-02 0.826000
Transport of small molecules 338 2.78e-02 -7.02e-02 0.245000
Synthesis of PIPs at the plasma membrane 36 4.69e-01 6.97e-02 0.792000
Translocation of SLC2A4 (GLUT4) to the plasma membrane 44 4.25e-01 6.96e-02 0.748000
Transcriptional regulation by RUNX1 125 1.83e-01 6.91e-02 0.497000
Deactivation of the beta-catenin transactivating complex 27 5.38e-01 -6.84e-02 0.830000
ERKs are inactivated 11 6.94e-01 -6.84e-02 0.894000
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 22 5.80e-01 -6.82e-02 0.846000
Programmed Cell Death 150 1.51e-01 6.82e-02 0.456000
Hyaluronan metabolism 10 7.09e-01 -6.80e-02 0.901000
Role of phospholipids in phagocytosis 16 6.38e-01 6.79e-02 0.865000
Transcriptional Regulation by MECP2 28 5.36e-01 6.75e-02 0.829000
Negative regulators of DDX58/IFIH1 signaling 34 4.96e-01 6.75e-02 0.808000
SUMOylation of immune response proteins 10 7.13e-01 -6.73e-02 0.901000
SUMOylation of DNA damage response and repair proteins 66 3.46e-01 6.71e-02 0.668000
Meiotic synapsis 22 5.86e-01 6.71e-02 0.847000
SUMOylation 136 1.81e-01 6.66e-02 0.497000
SUMOylation of RNA binding proteins 41 4.61e-01 6.66e-02 0.782000
FCERI mediated MAPK activation 22 5.89e-01 -6.66e-02 0.847000
Pausing and recovery of Tat-mediated HIV elongation 22 5.90e-01 6.64e-02 0.847000
Tat-mediated HIV elongation arrest and recovery 22 5.90e-01 6.64e-02 0.847000
Senescence-Associated Secretory Phenotype (SASP) 39 4.75e-01 -6.61e-02 0.794000
p75NTR signals via NF-kB 11 7.04e-01 -6.61e-02 0.901000
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 6.80e-01 -6.61e-02 0.891000
Mitochondrial biogenesis 53 4.06e-01 6.60e-02 0.729000
Formation of tubulin folding intermediates by CCT/TriC 13 6.83e-01 6.55e-02 0.891000
TNFR1-induced NFkappaB signaling pathway 19 6.21e-01 6.55e-02 0.864000
Signaling by NOTCH 130 2.01e-01 6.51e-02 0.517000
Pre-NOTCH Processing in Golgi 16 6.52e-01 6.50e-02 0.873000
DAP12 interactions 21 6.06e-01 6.50e-02 0.856000
C-type lectin receptors (CLRs) 97 2.71e-01 6.48e-02 0.592000
Signaling by Interleukins 258 7.54e-02 6.47e-02 0.362000
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 6.17e-01 -6.46e-02 0.864000
Neurodegenerative Diseases 20 6.17e-01 -6.46e-02 0.864000
Interleukin-35 Signalling 11 7.12e-01 -6.44e-02 0.901000
Pyruvate metabolism and Citric Acid (TCA) cycle 40 4.82e-01 -6.43e-02 0.799000
Interleukin-1 family signaling 93 2.86e-01 6.41e-02 0.607000
Pre-NOTCH Transcription and Translation 27 5.65e-01 6.39e-02 0.840000
Nuclear import of Rev protein 30 5.45e-01 6.39e-02 0.837000
Mitotic Spindle Checkpoint 93 2.91e-01 6.35e-02 0.607000
RHO GTPase Effectors 185 1.39e-01 6.34e-02 0.436000
Metal ion SLC transporters 15 6.71e-01 -6.33e-02 0.885000
Molecules associated with elastic fibres 11 7.16e-01 -6.33e-02 0.901000
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 7.18e-01 -6.29e-02 0.902000
Metabolism of amino acids and derivatives 219 1.11e-01 6.28e-02 0.416000
RNA Polymerase I Promoter Clearance 44 4.71e-01 6.28e-02 0.792000
RNA Polymerase I Transcription 44 4.71e-01 6.28e-02 0.792000
Signaling by NTRK3 (TRKC) 10 7.32e-01 -6.26e-02 0.904000
Cellular response to heat stress 77 3.44e-01 6.24e-02 0.668000
Leishmania infection 109 2.62e-01 -6.24e-02 0.584000
Signaling by FLT3 ITD and TKD mutants 12 7.09e-01 -6.23e-02 0.901000
Visual phototransduction 32 5.46e-01 -6.17e-02 0.838000
G beta:gamma signalling through PI3Kgamma 16 6.70e-01 6.16e-02 0.885000
Deposition of new CENPA-containing nucleosomes at the centromere 20 6.34e-01 -6.15e-02 0.864000
Nucleosome assembly 20 6.34e-01 -6.15e-02 0.864000
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 21 6.28e-01 -6.12e-02 0.864000
Protein methylation 10 7.39e-01 -6.08e-02 0.904000
BBSome-mediated cargo-targeting to cilium 18 6.57e-01 6.05e-02 0.875000
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 5.87e-01 6.04e-02 0.847000
NGF-stimulated transcription 25 6.01e-01 6.04e-02 0.852000
Metabolism of water-soluble vitamins and cofactors 78 3.58e-01 6.03e-02 0.674000
Zinc transporters 11 7.30e-01 -6.01e-02 0.904000
Regulation of IFNA/IFNB signaling 12 7.19e-01 6.00e-02 0.902000
Cleavage of the damaged purine 10 7.43e-01 5.99e-02 0.904000
Depurination 10 7.43e-01 5.99e-02 0.904000
Recognition and association of DNA glycosylase with site containing an affected purine 10 7.43e-01 5.99e-02 0.904000
Smooth Muscle Contraction 19 6.54e-01 5.95e-02 0.873000
Post-translational protein phosphorylation 34 5.49e-01 5.95e-02 0.838000
Regulated Necrosis 42 5.06e-01 5.94e-02 0.809000
Negative epigenetic regulation of rRNA expression 44 5.00e-01 5.88e-02 0.808000
Immune System 1114 1.37e-03 5.86e-02 0.062900
Late Phase of HIV Life Cycle 110 2.90e-01 5.85e-02 0.607000
RNA Polymerase III Transcription Termination 21 6.43e-01 5.85e-02 0.867000
RHOBTB1 GTPase cycle 18 6.68e-01 -5.85e-02 0.883000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 21 6.46e-01 -5.79e-02 0.869000
Thromboxane signalling through TP receptor 14 7.09e-01 -5.75e-02 0.901000
Innate Immune System 593 1.87e-02 5.74e-02 0.217000
ADP signalling through P2Y purinoceptor 12 12 7.31e-01 -5.74e-02 0.904000
Heme biosynthesis 10 7.54e-01 5.73e-02 0.910000
NR1H2 and NR1H3-mediated signaling 25 6.22e-01 5.70e-02 0.864000
EPH-ephrin mediated repulsion of cells 24 6.31e-01 -5.67e-02 0.864000
Prefoldin mediated transfer of substrate to CCT/TriC 16 6.95e-01 5.65e-02 0.894000
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 6.26e-01 -5.64e-02 0.864000
Peroxisomal lipid metabolism 20 6.63e-01 -5.63e-02 0.880000
Interferon Signaling 138 2.57e-01 5.61e-02 0.582000
NCAM signaling for neurite out-growth 23 6.42e-01 -5.59e-02 0.867000
HSF1 activation 21 6.59e-01 5.57e-02 0.876000
Sensory processing of sound 25 6.31e-01 5.55e-02 0.864000
Sensory processing of sound by inner hair cells of the cochlea 25 6.31e-01 5.55e-02 0.864000
Hedgehog ‘on’ state 62 4.54e-01 5.51e-02 0.776000
DNA Damage Recognition in GG-NER 35 5.76e-01 -5.47e-02 0.842000
Ovarian tumor domain proteases 29 6.16e-01 -5.39e-02 0.864000
Ub-specific processing proteases 132 2.87e-01 5.38e-02 0.607000
RNA Polymerase I Promoter Escape 27 6.30e-01 5.36e-02 0.864000
ESR-mediated signaling 112 3.29e-01 5.36e-02 0.651000
Integration of energy metabolism 58 4.81e-01 -5.35e-02 0.799000
Epigenetic regulation of gene expression 74 4.29e-01 5.33e-02 0.751000
Activation of HOX genes during differentiation 37 5.76e-01 5.32e-02 0.842000
Activation of anterior HOX genes in hindbrain development during early embryogenesis 37 5.76e-01 5.32e-02 0.842000
Interactions of Rev with host cellular proteins 33 5.98e-01 5.31e-02 0.850000
PINK1-PRKN Mediated Mitophagy 20 6.82e-01 5.30e-02 0.891000
Detoxification of Reactive Oxygen Species 22 6.67e-01 -5.29e-02 0.883000
Regulation of HSF1-mediated heat shock response 64 4.66e-01 5.28e-02 0.787000
Transcriptional activation of mitochondrial biogenesis 39 5.69e-01 5.27e-02 0.842000
Signaling by VEGF 72 4.41e-01 5.26e-02 0.761000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 30 6.18e-01 5.26e-02 0.864000
Signaling by RAF1 mutants 25 6.50e-01 -5.24e-02 0.872000
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 7.74e-01 -5.24e-02 0.919000
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 5.64e-01 5.21e-02 0.840000
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 5.64e-01 5.21e-02 0.840000
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 5.64e-01 5.21e-02 0.840000
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 5.64e-01 5.21e-02 0.840000
Signaling by NOTCH1 in Cancer 41 5.64e-01 5.21e-02 0.840000
activated TAK1 mediates p38 MAPK activation 12 7.55e-01 5.20e-02 0.910000
Hedgehog ‘off’ state 74 4.40e-01 5.19e-02 0.761000
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 7.20e-01 5.18e-02 0.902000
Synthesis of PA 17 7.12e-01 -5.17e-02 0.901000
HIV Life Cycle 122 3.29e-01 5.14e-02 0.651000
G beta:gamma signalling through CDC42 12 7.58e-01 -5.13e-02 0.910000
Positive epigenetic regulation of rRNA expression 40 5.75e-01 5.12e-02 0.842000
Metabolism of steroid hormones 13 7.49e-01 5.12e-02 0.907000
Deadenylation of mRNA 22 6.78e-01 5.11e-02 0.890000
Synthesis of substrates in N-glycan biosythesis 46 5.54e-01 -5.04e-02 0.840000
Oxidative Stress Induced Senescence 51 5.35e-01 5.02e-02 0.829000
Retrograde transport at the Trans-Golgi-Network 43 5.69e-01 5.02e-02 0.842000
Adaptive Immune System 464 6.92e-02 4.98e-02 0.343000
Signaling by Erythropoietin 19 7.08e-01 -4.96e-02 0.901000
Downstream signal transduction 20 7.01e-01 -4.95e-02 0.900000
Muscle contraction 66 4.89e-01 -4.93e-02 0.803000
Platelet degranulation 47 5.59e-01 -4.93e-02 0.840000
Interleukin-17 signaling 49 5.51e-01 -4.93e-02 0.838000
Rev-mediated nuclear export of HIV RNA 32 6.30e-01 4.92e-02 0.864000
Purine salvage 11 7.78e-01 4.92e-02 0.919000
RHOJ GTPase cycle 34 6.20e-01 -4.92e-02 0.864000
Axon guidance 290 1.54e-01 4.91e-02 0.460000
Generation of second messenger molecules 16 7.34e-01 4.90e-02 0.904000
VEGFA-VEGFR2 Pathway 70 4.80e-01 4.89e-02 0.798000
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 25 6.74e-01 4.86e-02 0.888000
Nervous system development 301 1.50e-01 4.86e-02 0.456000
Interleukin-6 signaling 10 7.91e-01 -4.84e-02 0.919000
G alpha (12/13) signalling events 35 6.21e-01 -4.84e-02 0.864000
The role of Nef in HIV-1 replication and disease pathogenesis 19 7.15e-01 4.83e-02 0.901000
Activation of gene expression by SREBF (SREBP) 35 6.22e-01 -4.82e-02 0.864000
Cytosolic sensors of pathogen-associated DNA 52 5.50e-01 -4.80e-02 0.838000
Kinesins 32 6.44e-01 4.72e-02 0.867000
MAPK targets/ Nuclear events mediated by MAP kinases 22 7.02e-01 -4.71e-02 0.900000
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 66 5.11e-01 -4.69e-02 0.810000
Toll Like Receptor 2 (TLR2) Cascade 66 5.11e-01 -4.69e-02 0.810000
Toll Like Receptor TLR1:TLR2 Cascade 66 5.11e-01 -4.69e-02 0.810000
Toll Like Receptor TLR6:TLR2 Cascade 66 5.11e-01 -4.69e-02 0.810000
Downstream signaling of activated FGFR1 11 7.88e-01 4.69e-02 0.919000
Downstream signaling of activated FGFR2 11 7.88e-01 4.69e-02 0.919000
Downstream signaling of activated FGFR3 11 7.88e-01 4.69e-02 0.919000
Downstream signaling of activated FGFR4 11 7.88e-01 4.69e-02 0.919000
G alpha (z) signalling events 24 6.92e-01 -4.68e-02 0.894000
Antigen processing: Ubiquitination & Proteasome degradation 233 2.22e-01 4.67e-02 0.542000
Translation of Replicase and Assembly of the Replication Transcription Complex 10 7.99e-01 4.66e-02 0.919000
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 69 5.05e-01 4.65e-02 0.809000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 35 6.35e-01 4.65e-02 0.864000
TICAM1, RIP1-mediated IKK complex recruitment 17 7.40e-01 4.64e-02 0.904000
Mitophagy 25 6.88e-01 -4.64e-02 0.891000
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 6.94e-01 4.54e-02 0.894000
Biological oxidations 78 4.90e-01 -4.53e-02 0.804000
Signaling by ERBB2 ECD mutants 10 8.04e-01 4.52e-02 0.921000
Ion transport by P-type ATPases 27 6.86e-01 4.50e-02 0.891000
DDX58/IFIH1-mediated induction of interferon-alpha/beta 58 5.54e-01 4.49e-02 0.840000
RHOH GTPase cycle 27 6.87e-01 4.49e-02 0.891000
Nonhomologous End-Joining (NHEJ) 27 6.87e-01 4.48e-02 0.891000
NOTCH1 Intracellular Domain Regulates Transcription 37 6.42e-01 4.42e-02 0.867000
Interconversion of nucleotide di- and triphosphates 21 7.31e-01 4.34e-02 0.904000
Growth hormone receptor signaling 17 7.59e-01 -4.30e-02 0.910000
PKMTs methylate histone lysines 24 7.16e-01 4.30e-02 0.901000
Signaling by PDGF 24 7.17e-01 -4.28e-02 0.901000
SLC transporter disorders 49 6.06e-01 4.27e-02 0.856000
Regulation of TNFR1 signaling 30 6.88e-01 4.24e-02 0.891000
Adrenaline,noradrenaline inhibits insulin secretion 13 7.93e-01 4.20e-02 0.919000
RHOA GTPase cycle 86 5.07e-01 4.15e-02 0.809000
Class I MHC mediated antigen processing & presentation 277 2.39e-01 4.14e-02 0.561000
CTNNB1 S33 mutants aren’t phosphorylated 13 7.97e-01 -4.12e-02 0.919000
CTNNB1 S37 mutants aren’t phosphorylated 13 7.97e-01 -4.12e-02 0.919000
CTNNB1 S45 mutants aren’t phosphorylated 13 7.97e-01 -4.12e-02 0.919000
CTNNB1 T41 mutants aren’t phosphorylated 13 7.97e-01 -4.12e-02 0.919000
Signaling by CTNNB1 phospho-site mutants 13 7.97e-01 -4.12e-02 0.919000
Signaling by GSK3beta mutants 13 7.97e-01 -4.12e-02 0.919000
InlB-mediated entry of Listeria monocytogenes into host cell 11 8.14e-01 -4.10e-02 0.922000
IKK complex recruitment mediated by RIP1 17 7.71e-01 4.08e-02 0.919000
Resolution of D-loop Structures through Holliday Junction Intermediates 24 7.30e-01 4.07e-02 0.904000
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 7.96e-01 -4.00e-02 0.919000
PPARA activates gene expression 82 5.34e-01 3.98e-02 0.829000
Transcriptional Regulation by E2F6 28 7.16e-01 -3.98e-02 0.901000
Formation of Incision Complex in GG-NER 36 6.80e-01 -3.97e-02 0.891000
Regulation of lipid metabolism by PPARalpha 84 5.31e-01 3.96e-02 0.829000
RHOBTB GTPase Cycle 29 7.14e-01 3.94e-02 0.901000
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 7.93e-01 -3.92e-02 0.919000
Signaling by FGFR2 in disease 23 7.46e-01 3.90e-02 0.905000
Glycosphingolipid metabolism 25 7.38e-01 3.86e-02 0.904000
trans-Golgi Network Vesicle Budding 50 6.37e-01 3.86e-02 0.865000
Signalling to ERKs 25 7.39e-01 -3.85e-02 0.904000
RND1 GTPase cycle 29 7.22e-01 3.82e-02 0.903000
Response to elevated platelet cytosolic Ca2+ 51 6.39e-01 -3.80e-02 0.865000
COPI-dependent Golgi-to-ER retrograde traffic 66 5.95e-01 3.78e-02 0.849000
TP53 Regulates Metabolic Genes 61 6.10e-01 3.78e-02 0.860000
Sensory Perception 64 6.03e-01 -3.77e-02 0.853000
PCP/CE pathway 70 5.86e-01 3.77e-02 0.847000
Interleukin-7 signaling 14 8.08e-01 3.75e-02 0.922000
Gene expression (Transcription) 981 5.38e-02 3.74e-02 0.310000
Regulation of insulin secretion 38 6.93e-01 -3.70e-02 0.894000
Autophagy 95 5.35e-01 -3.69e-02 0.829000
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 14 8.13e-01 3.65e-02 0.922000
Peroxisomal protein import 46 6.71e-01 3.63e-02 0.885000
VEGFR2 mediated cell proliferation 16 8.02e-01 -3.62e-02 0.920000
Metabolism of proteins 1205 4.10e-02 3.61e-02 0.281000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 7.25e-01 3.60e-02 0.904000
B-WICH complex positively regulates rRNA expression 27 7.47e-01 3.59e-02 0.905000
Synthesis of PIPs at the early endosome membrane 12 8.30e-01 -3.59e-02 0.931000
Nuclear Receptor transcription pathway 26 7.54e-01 -3.55e-02 0.910000
Cellular response to chemical stress 141 4.70e-01 3.54e-02 0.792000
Cytochrome P450 - arranged by substrate type 14 8.19e-01 -3.53e-02 0.926000
Negative regulation of MAPK pathway 36 7.15e-01 -3.52e-02 0.901000
Transcriptional regulation by RUNX2 82 5.83e-01 3.51e-02 0.847000
Netrin-1 signaling 24 7.69e-01 -3.47e-02 0.917000
Signaling by KIT in disease 16 8.10e-01 -3.46e-02 0.922000
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 8.10e-01 -3.46e-02 0.922000
RAB GEFs exchange GTP for GDP on RABs 56 6.55e-01 -3.45e-02 0.874000
Metabolism of vitamins and cofactors 107 5.41e-01 3.43e-02 0.832000
RAC1 GTPase cycle 103 5.49e-01 3.43e-02 0.838000
PI Metabolism 60 6.51e-01 3.38e-02 0.872000
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 7.41e-01 -3.33e-02 0.904000
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 49 6.87e-01 3.33e-02 0.891000
PI3K Cascade 18 8.07e-01 3.32e-02 0.922000
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 7.57e-01 3.32e-02 0.910000
Signaling by RAS mutants 29 7.57e-01 3.32e-02 0.910000
Signaling by moderate kinase activity BRAF mutants 29 7.57e-01 3.32e-02 0.910000
Signaling downstream of RAS mutants 29 7.57e-01 3.32e-02 0.910000
Nephrin family interactions 14 8.30e-01 3.32e-02 0.931000
VEGFR2 mediated vascular permeability 21 7.93e-01 -3.30e-02 0.919000
Pexophagy 11 8.51e-01 -3.27e-02 0.946000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 7.95e-01 -3.27e-02 0.919000
Developmental Biology 448 2.43e-01 3.25e-02 0.569000
Signaling by Non-Receptor Tyrosine Kinases 35 7.40e-01 -3.24e-02 0.904000
Signaling by PTK6 35 7.40e-01 -3.24e-02 0.904000
Neutrophil degranulation 292 3.45e-01 3.23e-02 0.668000
Transcriptional regulation of white adipocyte differentiation 56 6.77e-01 3.22e-02 0.890000
Signaling by FGFR in disease 38 7.32e-01 -3.21e-02 0.904000
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 7.46e-01 3.21e-02 0.905000
Defective Intrinsic Pathway for Apoptosis 23 7.90e-01 -3.20e-02 0.919000
Signaling by BRAF and RAF1 fusions 42 7.22e-01 -3.18e-02 0.903000
IRS-mediated signalling 20 8.10e-01 -3.11e-02 0.922000
DNA Damage Bypass 41 7.33e-01 3.08e-02 0.904000
Asparagine N-linked glycosylation 219 4.35e-01 3.08e-02 0.755000
Factors involved in megakaryocyte development and platelet production 85 6.25e-01 3.07e-02 0.864000
Chaperonin-mediated protein folding 55 6.97e-01 -3.04e-02 0.895000
SHC1 events in ERBB2 signaling 11 8.62e-01 -3.03e-02 0.951000
Antiviral mechanism by IFN-stimulated genes 74 6.53e-01 3.03e-02 0.873000
Hemostasis 297 3.76e-01 -3.01e-02 0.695000
ER to Golgi Anterograde Transport 103 5.99e-01 3.00e-02 0.850000
Downregulation of TGF-beta receptor signaling 26 7.92e-01 -3.00e-02 0.919000
G1/S-Specific Transcription 24 8.00e-01 -2.99e-02 0.919000
DNA Repair 238 4.30e-01 2.99e-02 0.751000
The citric acid (TCA) cycle and respiratory electron transport 113 5.84e-01 2.99e-02 0.847000
Nuclear Events (kinase and transcription factor activation) 42 7.38e-01 2.99e-02 0.904000
TCF dependent signaling in response to WNT 117 5.78e-01 2.98e-02 0.845000
Syndecan interactions 10 8.74e-01 -2.90e-02 0.951000
Degradation of the extracellular matrix 28 7.91e-01 2.89e-02 0.919000
Intrinsic Pathway for Apoptosis 45 7.38e-01 2.88e-02 0.904000
Termination of translesion DNA synthesis 28 7.98e-01 2.79e-02 0.919000
Nucleotide Excision Repair 99 6.33e-01 2.79e-02 0.864000
Cargo trafficking to the periciliary membrane 39 7.65e-01 -2.77e-02 0.916000
Transport to the Golgi and subsequent modification 126 5.93e-01 2.76e-02 0.849000
Non-integrin membrane-ECM interactions 13 8.64e-01 -2.74e-02 0.951000
RND3 GTPase cycle 29 7.99e-01 2.74e-02 0.919000
Dual Incision in GG-NER 35 7.81e-01 2.72e-02 0.919000
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 37 7.75e-01 -2.71e-02 0.919000
IRS-related events triggered by IGF1R 21 8.31e-01 -2.69e-02 0.931000
Negative regulation of the PI3K/AKT network 54 7.33e-01 2.69e-02 0.904000
RNA Polymerase II Transcription 873 1.88e-01 2.69e-02 0.500000
Diseases of mitotic cell cycle 30 7.99e-01 2.68e-02 0.919000
Metabolism of porphyrins 15 8.59e-01 -2.65e-02 0.951000
Signaling by Rho GTPases 421 3.57e-01 2.64e-02 0.673000
Translesion synthesis by POLK 15 8.61e-01 -2.61e-02 0.951000
Transcriptional Regulation by VENTX 25 8.23e-01 2.59e-02 0.928000
Golgi Associated Vesicle Biogenesis 37 7.86e-01 -2.58e-02 0.919000
TAK1-dependent IKK and NF-kappa-B activation 17 8.55e-01 2.57e-02 0.948000
RMTs methylate histone arginines 25 8.26e-01 2.54e-02 0.929000
Semaphorin interactions 36 7.93e-01 2.53e-02 0.919000
mRNA decay by 5’ to 3’ exoribonuclease 14 8.71e-01 -2.50e-02 0.951000
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 15 8.68e-01 2.48e-02 0.951000
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 15 8.68e-01 2.48e-02 0.951000
TNF signaling 35 8.00e-01 2.48e-02 0.919000
TP53 Regulates Transcription of Cell Death Genes 30 8.15e-01 -2.47e-02 0.922000
Early Phase of HIV Life Cycle 13 8.78e-01 2.45e-02 0.951000
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 433 3.90e-01 2.44e-02 0.714000
MyD88 dependent cascade initiated on endosome 63 7.43e-01 -2.39e-02 0.904000
Toll Like Receptor 7/8 (TLR7/8) Cascade 63 7.43e-01 -2.39e-02 0.904000
Glucose metabolism 70 7.30e-01 2.39e-02 0.904000
Interleukin-15 signaling 11 8.91e-01 2.39e-02 0.956000
Association of TriC/CCT with target proteins during biosynthesis 29 8.25e-01 -2.37e-02 0.929000
Signaling by WNT 171 5.97e-01 2.35e-02 0.850000
Signaling by TGFB family members 82 7.13e-01 -2.35e-02 0.901000
Macroautophagy 87 7.06e-01 -2.35e-02 0.901000
DNA Double Strand Break Response 34 8.13e-01 2.34e-02 0.922000
Selective autophagy 50 7.75e-01 2.34e-02 0.919000
TGF-beta receptor signaling activates SMADs 37 8.07e-01 -2.32e-02 0.922000
Glycolysis 55 7.68e-01 2.30e-02 0.917000
DCC mediated attractive signaling 11 8.95e-01 2.30e-02 0.958000
Rab regulation of trafficking 85 7.15e-01 2.30e-02 0.901000
Synthesis of IP3 and IP4 in the cytosol 16 8.77e-01 -2.23e-02 0.951000
Platelet activation, signaling and aggregation 128 6.66e-01 2.21e-02 0.883000
PRC2 methylates histones and DNA 11 9.00e-01 2.18e-02 0.960000
MAP kinase activation 46 7.98e-01 -2.18e-02 0.919000
Gap junction trafficking and regulation 10 9.06e-01 -2.16e-02 0.961000
Phase II - Conjugation of compounds 45 8.05e-01 -2.13e-02 0.921000
Pre-NOTCH Expression and Processing 42 8.11e-01 2.13e-02 0.922000
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 21 8.68e-01 -2.09e-02 0.951000
Signaling by NOTCH2 18 8.79e-01 -2.08e-02 0.951000
Phospholipid metabolism 131 6.84e-01 2.06e-02 0.891000
RHO GTPase cycle 280 5.55e-01 2.06e-02 0.840000
Post-translational protein modification 882 3.10e-01 2.06e-02 0.632000
FLT3 signaling in disease 24 8.61e-01 2.06e-02 0.951000
Cyclin D associated events in G1 40 8.22e-01 2.06e-02 0.928000
G1 Phase 40 8.22e-01 2.06e-02 0.928000
CDC42 GTPase cycle 90 7.37e-01 -2.06e-02 0.904000
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 19 8.78e-01 2.04e-02 0.951000
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 19 8.78e-01 2.04e-02 0.951000
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 19 8.78e-01 2.04e-02 0.951000
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 19 8.78e-01 2.04e-02 0.951000
Impaired BRCA2 binding to PALB2 19 8.78e-01 2.04e-02 0.951000
Oncogenic MAPK signaling 56 7.94e-01 -2.02e-02 0.919000
SUMOylation of transcription factors 13 9.01e-01 -2.00e-02 0.960000
ERK/MAPK targets 16 8.91e-01 -1.98e-02 0.956000
Interferon gamma signaling 54 8.01e-01 1.98e-02 0.920000
RORA activates gene expression 11 9.10e-01 1.97e-02 0.962000
Interleukin-37 signaling 16 8.92e-01 1.96e-02 0.956000
IGF1R signaling cascade 22 8.74e-01 1.95e-02 0.951000
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 22 8.74e-01 1.95e-02 0.951000
Deubiquitination 194 6.41e-01 1.95e-02 0.867000
Signaling by PDGFR in disease 15 8.99e-01 -1.90e-02 0.959000
RND2 GTPase cycle 33 8.52e-01 -1.87e-02 0.947000
Mitochondrial translation 88 7.66e-01 1.84e-02 0.916000
Pyroptosis 17 8.99e-01 -1.78e-02 0.959000
Extracellular matrix organization 78 7.86e-01 -1.78e-02 0.919000
RAF activation 28 8.72e-01 1.76e-02 0.951000
Toll Like Receptor 9 (TLR9) Cascade 65 8.06e-01 -1.76e-02 0.922000
EGFR downregulation 20 8.92e-01 1.75e-02 0.956000
Cell surface interactions at the vascular wall 56 8.23e-01 1.73e-02 0.928000
MAP2K and MAPK activation 22 8.89e-01 -1.73e-02 0.956000
Signaling by high-kinase activity BRAF mutants 22 8.89e-01 -1.73e-02 0.956000
Toll-like Receptor Cascades 100 7.66e-01 1.72e-02 0.916000
Formation of TC-NER Pre-Incision Complex 46 8.41e-01 1.71e-02 0.938000
Aberrant regulation of mitotic exit in cancer due to RB1 defects 15 9.11e-01 1.67e-02 0.962000
Calnexin/calreticulin cycle 23 8.90e-01 -1.67e-02 0.956000
Postmitotic nuclear pore complex (NPC) reformation 25 8.86e-01 1.65e-02 0.956000
Signaling by FLT3 fusion proteins 16 9.09e-01 -1.64e-02 0.962000
Translesion synthesis by POLI 15 9.13e-01 -1.63e-02 0.963000
RAC2 GTPase cycle 52 8.42e-01 -1.60e-02 0.938000
Synthesis of glycosylphosphatidylinositol (GPI) 14 9.19e-01 -1.57e-02 0.965000
MyD88 cascade initiated on plasma membrane 61 8.35e-01 -1.55e-02 0.933000
Toll Like Receptor 10 (TLR10) Cascade 61 8.35e-01 -1.55e-02 0.933000
Toll Like Receptor 5 (TLR5) Cascade 61 8.35e-01 -1.55e-02 0.933000
Mitochondrial Fatty Acid Beta-Oxidation 25 8.94e-01 -1.54e-02 0.958000
Inositol phosphate metabolism 29 8.89e-01 1.50e-02 0.956000
MET promotes cell motility 12 9.29e-01 1.49e-02 0.973000
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 15 9.21e-01 -1.48e-02 0.965000
COPII-mediated vesicle transport 48 8.64e-01 1.43e-02 0.951000
Protein folding 61 8.50e-01 -1.40e-02 0.946000
G-protein beta:gamma signalling 20 9.15e-01 1.38e-02 0.963000
RAS processing 13 9.31e-01 -1.38e-02 0.974000
EPH-Ephrin signaling 54 8.61e-01 1.38e-02 0.951000
Drug ADME 27 9.02e-01 -1.37e-02 0.960000
Signaling by NOTCH1 51 8.67e-01 -1.36e-02 0.951000
Glutathione conjugation 21 9.16e-01 -1.34e-02 0.963000
Signaling by Nuclear Receptors 148 7.88e-01 -1.29e-02 0.919000
Beta-catenin independent WNT signaling 101 8.27e-01 1.26e-02 0.929000
EPHB-mediated forward signaling 25 9.14e-01 1.25e-02 0.963000
SUMOylation of chromatin organization proteins 48 8.86e-01 -1.20e-02 0.956000
Vesicle-mediated transport 434 6.76e-01 1.18e-02 0.889000
EGR2 and SOX10-mediated initiation of Schwann cell myelination 12 9.45e-01 1.16e-02 0.982000
Metabolism of lipids 420 6.94e-01 -1.13e-02 0.894000
Amino acids regulate mTORC1 35 9.09e-01 1.12e-02 0.962000
Global Genome Nucleotide Excision Repair (GG-NER) 76 8.68e-01 1.10e-02 0.951000
Glycerophospholipid biosynthesis 72 8.72e-01 1.10e-02 0.951000
Phase I - Functionalization of compounds 30 9.18e-01 -1.08e-02 0.964000
Signaling by EGFR in Cancer 16 9.42e-01 -1.06e-02 0.981000
Metabolism of folate and pterines 11 9.52e-01 -1.05e-02 0.982000
Gluconeogenesis 24 9.30e-01 -1.03e-02 0.974000
Signaling by NTRK1 (TRKA) 79 8.75e-01 1.03e-02 0.951000
Regulation of cholesterol biosynthesis by SREBP (SREBF) 47 9.05e-01 -1.01e-02 0.961000
Membrane Trafficking 426 7.41e-01 9.45e-03 0.904000
Effects of PIP2 hydrolysis 18 9.46e-01 9.27e-03 0.982000
Translesion synthesis by REV1 14 9.53e-01 -9.19e-03 0.982000
Phosphorylation of the APC/C 15 9.52e-01 9.05e-03 0.982000
Signaling by TGF-beta Receptor Complex 69 8.97e-01 -9.03e-03 0.959000
APC truncation mutants have impaired AXIN binding 12 9.57e-01 9.03e-03 0.982000
AXIN missense mutants destabilize the destruction complex 12 9.57e-01 9.03e-03 0.982000
Signaling by AMER1 mutants 12 9.57e-01 9.03e-03 0.982000
Signaling by APC mutants 12 9.57e-01 9.03e-03 0.982000
Signaling by AXIN mutants 12 9.57e-01 9.03e-03 0.982000
Truncations of AMER1 destabilize the destruction complex 12 9.57e-01 9.03e-03 0.982000
Protein ubiquitination 56 9.07e-01 8.99e-03 0.961000
Metabolism 1204 6.11e-01 8.99e-03 0.860000
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 62 9.03e-01 -8.95e-03 0.960000
Oncogene Induced Senescence 27 9.37e-01 8.84e-03 0.979000
Response of EIF2AK1 (HRI) to heme deficiency 14 9.55e-01 8.74e-03 0.982000
Signaling by Hedgehog 98 8.82e-01 -8.69e-03 0.954000
SUMOylation of intracellular receptors 19 9.51e-01 -8.09e-03 0.982000
TRAF6 mediated IRF7 activation 16 9.59e-01 7.49e-03 0.982000
Signaling by NTRKs 86 9.07e-01 7.32e-03 0.961000
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 37 9.39e-01 7.27e-03 0.979000
Mitochondrial translation initiation 83 9.17e-01 6.62e-03 0.964000
Signaling by Receptor Tyrosine Kinases 286 8.50e-01 -6.56e-03 0.946000
E3 ubiquitin ligases ubiquitinate target proteins 40 9.46e-01 6.18e-03 0.982000
Translesion Synthesis by POLH 16 9.66e-01 -6.14e-03 0.985000
Resolution of D-Loop Structures 25 9.58e-01 6.13e-03 0.982000
Striated Muscle Contraction 10 9.75e-01 -5.82e-03 0.985000
Signaling by FGFR 51 9.43e-01 5.80e-03 0.982000
Generic Transcription Pathway 784 7.95e-01 5.58e-03 0.919000
Signal Transduction 1305 7.50e-01 5.45e-03 0.907000
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 9.73e-01 -5.28e-03 0.985000
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 9.73e-01 -5.28e-03 0.985000
Signaling by NTRK2 (TRKB) 15 9.72e-01 -5.25e-03 0.985000
Diseases associated with the TLR signaling cascade 16 9.71e-01 -5.20e-03 0.985000
Diseases of Immune System 16 9.71e-01 -5.20e-03 0.985000
Mitochondrial translation elongation 83 9.38e-01 -4.95e-03 0.979000
Signaling by SCF-KIT 32 9.63e-01 4.70e-03 0.985000
Toll Like Receptor 3 (TLR3) Cascade 71 9.49e-01 4.42e-03 0.982000
Extra-nuclear estrogen signaling 48 9.58e-01 -4.36e-03 0.982000
N-glycan antennae elongation in the medial/trans-Golgi 18 9.76e-01 -4.14e-03 0.985000
Lysosome Vesicle Biogenesis 24 9.73e-01 -3.98e-03 0.985000
ER Quality Control Compartment (ERQC) 18 9.77e-01 -3.90e-03 0.985000
Mitochondrial translation termination 82 9.57e-01 -3.48e-03 0.982000
Signaling by FGFR2 47 9.71e-01 -3.09e-03 0.985000
ISG15 antiviral mechanism 68 9.67e-01 -2.92e-03 0.985000
MHC class II antigen presentation 66 9.68e-01 2.85e-03 0.985000
Metabolism of steroids 83 9.65e-01 -2.82e-03 0.985000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 59 9.75e-01 2.40e-03 0.985000
Toll Like Receptor 4 (TLR4) Cascade 89 9.70e-01 -2.31e-03 0.985000
SARS-CoV-2 activates/modulates innate and adaptive immune responses 85 9.76e-01 -1.91e-03 0.985000
Signaling by ERBB2 33 9.85e-01 -1.87e-03 0.993000
SUMOylation of transcription cofactors 35 9.89e-01 1.39e-03 0.994000
RAC3 GTPase cycle 55 9.88e-01 1.13e-03 0.994000
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 33 9.91e-01 -1.09e-03 0.996000
MyD88-independent TLR4 cascade 71 9.92e-01 6.67e-04 0.996000
TRIF(TICAM1)-mediated TLR4 signaling 71 9.92e-01 6.67e-04 0.996000
Regulation of MECP2 expression and activity 20 9.97e-01 5.15e-04 0.998000
Aberrant regulation of mitotic cell cycle due to RB1 defects 29 9.97e-01 4.32e-04 0.998000
Endosomal Sorting Complex Required For Transport (ESCRT) 25 9.99e-01 -1.09e-04 1.000000
Signaling by ERBB2 in Cancer 13 1.00e+00 -3.73e-05 1.000000


Detailed Gene set reports



Regulation of FZD by ubiquitination

Regulation of FZD by ubiquitination
829
set Regulation of FZD by ubiquitination
setSize 12
pANOVA 0.000444
s.dist -0.585
p.adjustANOVA 0.0294



Top enriched genes

Top 20 genes
GeneID Gene Rank
WNT3A -2845.5
FZD6 -2804.5
FZD8 -2633.5
USP8 -1926.5
LRP5 -1748.5
UBC -1150.5
LRP6 -1006.5
UBB -759.5
FZD5 0.5
ZNRF3 0.5
RPS27A 759.5
UBA52 2326.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT3A -2845.5
FZD6 -2804.5
FZD8 -2633.5
USP8 -1926.5
LRP5 -1748.5
UBC -1150.5
LRP6 -1006.5
UBB -759.5
FZD5 0.5
ZNRF3 0.5
RPS27A 759.5
UBA52 2326.5


RUNX2 regulates osteoblast differentiation

RUNX2 regulates osteoblast differentiation
812
set RUNX2 regulates osteoblast differentiation
setSize 13
pANOVA 0.00027
s.dist -0.583
p.adjustANOVA 0.023



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL1A1 -3049.5
SATB2 -3016.5
MAPK1 -2100.5
MAF -2089.5
MAPK3 -1898.5
HDAC3 -1869.5
CBFB -1581.5
SRC -960.5
ABL1 -636.5
RUNX2 -591.5
HEY2 0.5
YES1 0.5
RB1 5174.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 -3049.5
SATB2 -3016.5
MAPK1 -2100.5
MAF -2089.5
MAPK3 -1898.5
HDAC3 -1869.5
CBFB -1581.5
SRC -960.5
ABL1 -636.5
RUNX2 -591.5
HEY2 0.5
YES1 0.5
RB1 5174.5


Glutamate Neurotransmitter Release Cycle

Glutamate Neurotransmitter Release Cycle
379
set Glutamate Neurotransmitter Release Cycle
setSize 11
pANOVA 0.0023
s.dist -0.531
p.adjustANOVA 0.083



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAB3A -2880.5
SLC1A1 -2820.5
ARL6IP5 -2479.5
PPFIA3 -2011.5
UNC13B -1625.5
PPFIA1 -1416.5
GLS 0.5
STXBP1 0.5
VAMP2 1077.5
STX1A 2039.5
SLC38A2 2409.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAB3A -2880.5
SLC1A1 -2820.5
ARL6IP5 -2479.5
PPFIA3 -2011.5
UNC13B -1625.5
PPFIA1 -1416.5
GLS 0.5
STXBP1 0.5
VAMP2 1077.5
STX1A 2039.5
SLC38A2 2409.5


Assembly of collagen fibrils and other multimeric structures

Assembly of collagen fibrils and other multimeric structures
65
set Assembly of collagen fibrils and other multimeric structures
setSize 10
pANOVA 0.0046
s.dist -0.517
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL1A1 -3049.5
TLL2 -2649.5
COL9A2 -2271.5
ITGB4 -1798.5
DST -1406.5
LOXL1 -929.5
CTSB 0.5
LOXL3 0.5
BMP1 0.5
ITGA6 5782.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 -3049.5
TLL2 -2649.5
COL9A2 -2271.5
ITGB4 -1798.5
DST -1406.5
LOXL1 -929.5
CTSB 0.5
LOXL3 0.5
BMP1 0.5
ITGA6 5782.5


Maturation of nucleoprotein

Maturation of nucleoprotein
526
set Maturation of nucleoprotein
setSize 11
pANOVA 0.00474
s.dist 0.492
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
PARP10 7119.5
GSK3A 7077.5
PARP4 6643.5
UBE2I 6548.5
PARP9 6421.0
GSK3B 6022.5
PARP14 5632.5
PARP16 4566.5
PARP6 2945.5
PARP8 0.5
SUMO1 -2748.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARP10 7119.5
GSK3A 7077.5
PARP4 6643.5
UBE2I 6548.5
PARP9 6421.0
GSK3B 6022.5
PARP14 5632.5
PARP16 4566.5
PARP6 2945.5
PARP8 0.5
SUMO1 -2748.5


Voltage gated Potassium channels

Voltage gated Potassium channels
1160
set Voltage gated Potassium channels
setSize 10
pANOVA 0.0076
s.dist -0.487
p.adjustANOVA 0.137



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNS1 -2978.5
KCNH4 -2826.5
KCNQ1 -2806.0
KCNQ5 -2456.5
KCNAB2 -1568.5
KCNC4 0.5
KCNG3 0.5
KCNH2 0.5
KCNQ4 1090.5
KCNA3 6769.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNS1 -2978.5
KCNH4 -2826.5
KCNQ1 -2806.0
KCNQ5 -2456.5
KCNAB2 -1568.5
KCNC4 0.5
KCNG3 0.5
KCNH2 0.5
KCNQ4 1090.5
KCNA3 6769.5


Neurotransmitter release cycle

Neurotransmitter release cycle
625
set Neurotransmitter release cycle
setSize 18
pANOVA 0.00036
s.dist -0.486
p.adjustANOVA 0.0266



Top enriched genes

Top 20 genes
GeneID Gene Rank
ABAT -2940.5
RAB3A -2880.5
SLC1A1 -2820.5
ARL6IP5 -2479.5
DNAJC5 -2219.5
APBA1 -2019.5
PPFIA3 -2011.5
UNC13B -1625.5
PPFIA1 -1416.5
LIN7B -991.5
ALDH5A1 0.5
GLS 0.5
STXBP1 0.5
VAMP2 1077.5
STX1A 2039.5
NAAA 2366.5
SLC38A2 2409.5
LIN7C 5109.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABAT -2940.5
RAB3A -2880.5
SLC1A1 -2820.5
ARL6IP5 -2479.5
DNAJC5 -2219.5
APBA1 -2019.5
PPFIA3 -2011.5
UNC13B -1625.5
PPFIA1 -1416.5
LIN7B -991.5
ALDH5A1 0.5
GLS 0.5
STXBP1 0.5
VAMP2 1077.5
STX1A 2039.5
NAAA 2366.5
SLC38A2 2409.5
LIN7C 5109.0


Regulation of pyruvate dehydrogenase (PDH) complex

Regulation of pyruvate dehydrogenase (PDH) complex
864
set Regulation of pyruvate dehydrogenase (PDH) complex
setSize 11
pANOVA 0.00698
s.dist -0.47
p.adjustANOVA 0.133



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDK2 -2904.5
PPARD -2865.5
DLD -2338.5
PDK1 -1431.5
PDHX -1067.0
PDHB -1037.5
PDP2 -785.5
PDP1 0.5
PDPR 0.5
DLAT 2227.5
GSTZ1 5956.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDK2 -2904.5
PPARD -2865.5
DLD -2338.5
PDK1 -1431.5
PDHX -1067.0
PDHB -1037.5
PDP2 -785.5
PDP1 0.5
PDPR 0.5
DLAT 2227.5
GSTZ1 5956.0


Dopamine Neurotransmitter Release Cycle

Dopamine Neurotransmitter Release Cycle
250
set Dopamine Neurotransmitter Release Cycle
setSize 10
pANOVA 0.0143
s.dist -0.447
p.adjustANOVA 0.187



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAB3A -2880.5
APBA1 -2019.5
PPFIA3 -2011.5
UNC13B -1625.5
PPFIA1 -1416.5
LIN7B -991.5
STXBP1 0.5
VAMP2 1077.5
STX1A 2039.5
LIN7C 5109.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAB3A -2880.5
APBA1 -2019.5
PPFIA3 -2011.5
UNC13B -1625.5
PPFIA1 -1416.5
LIN7B -991.5
STXBP1 0.5
VAMP2 1077.5
STX1A 2039.5
LIN7C 5109.0


Long-term potentiation

Long-term potentiation
508
set Long-term potentiation
setSize 11
pANOVA 0.0105
s.dist -0.446
p.adjustANOVA 0.162



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRIN2C -2550.5
DLG4 -2233.5
GRIN1 -1884.5
CAMK2G -1756.5
NRGN -1152.5
SRC -960.5
DLG1 -938.5
CALM1 -730.5
GRIN2D 0.5
DLG2 2819.5
CAMK2D 6506.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRIN2C -2550.5
DLG4 -2233.5
GRIN1 -1884.5
CAMK2G -1756.5
NRGN -1152.5
SRC -960.5
DLG1 -938.5
CALM1 -730.5
GRIN2D 0.5
DLG2 2819.5
CAMK2D 6506.5


PKA activation

PKA activation
672
set PKA activation
setSize 10
pANOVA 0.0174
s.dist -0.434
p.adjustANOVA 0.217



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAR1B -2946.5
ADCY7 -2888.5
PRKAR2A -2465.5
ADCY4 -2358.5
NBEA -1930.5
PRKACA -1900.5
CALM1 -730.5
PRKACB 3457.5
ADCY9 3676.5
PRKAR1A 6053.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAR1B -2946.5
ADCY7 -2888.5
PRKAR2A -2465.5
ADCY4 -2358.5
NBEA -1930.5
PRKACA -1900.5
CALM1 -730.5
PRKACB 3457.5
ADCY9 3676.5
PRKAR1A 6053.5


Signaling by Retinoic Acid

Signaling by Retinoic Acid
1001
set Signaling by Retinoic Acid
setSize 17
pANOVA 0.002
s.dist -0.433
p.adjustANOVA 0.077



Top enriched genes

Top 20 genes
GeneID Gene Rank
RDH13 -3072.5
PDK2 -2904.5
PPARD -2865.5
CPT1A -2545.5
DLD -2338.5
RARA -1605.5
PDK1 -1431.5
RDH14 -1330.5
PDHX -1067.0
PDHB -1037.5
DHRS4 -679.0
DHRS3 -642.5
FABP5 1514.5
DLAT 2227.5
RDH11 3929.5
RDH10 5166.0
RARG 5371.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RDH13 -3072.5
PDK2 -2904.5
PPARD -2865.5
CPT1A -2545.5
DLD -2338.5
RARA -1605.5
PDK1 -1431.5
RDH14 -1330.5
PDHX -1067.0
PDHB -1037.5
DHRS4 -679.0
DHRS3 -642.5
FABP5 1514.5
DLAT 2227.5
RDH11 3929.5
RDH10 5166.0
RARG 5371.5


PKA-mediated phosphorylation of CREB

PKA-mediated phosphorylation of CREB
673
set PKA-mediated phosphorylation of CREB
setSize 11
pANOVA 0.0134
s.dist -0.431
p.adjustANOVA 0.179



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAR1B -2946.5
ADCY7 -2888.5
PRKAR2A -2465.5
ADCY4 -2358.5
NBEA -1930.5
PRKACA -1900.5
CALM1 -730.5
CREB1 0.5
PRKACB 3457.5
ADCY9 3676.5
PRKAR1A 6053.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAR1B -2946.5
ADCY7 -2888.5
PRKAR2A -2465.5
ADCY4 -2358.5
NBEA -1930.5
PRKACA -1900.5
CALM1 -730.5
CREB1 0.5
PRKACB 3457.5
ADCY9 3676.5
PRKAR1A 6053.5


Negative regulation of NMDA receptor-mediated neuronal transmission

Negative regulation of NMDA receptor-mediated neuronal transmission
614
set Negative regulation of NMDA receptor-mediated neuronal transmission
setSize 12
pANOVA 0.0106
s.dist -0.426
p.adjustANOVA 0.162



Top enriched genes

Top 20 genes
GeneID Gene Rank
CAMK1 -2846.5
GRIN2C -2550.5
DLG4 -2233.5
GRIN1 -1884.5
CAMK2G -1756.5
PPM1F -1618.5
DLG1 -938.5
CALM1 -730.5
GRIN2D 0.5
DLG2 2819.5
CAMK4 3291.5
CAMK2D 6506.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAMK1 -2846.5
GRIN2C -2550.5
DLG4 -2233.5
GRIN1 -1884.5
CAMK2G -1756.5
PPM1F -1618.5
DLG1 -938.5
CALM1 -730.5
GRIN2D 0.5
DLG2 2819.5
CAMK4 3291.5
CAMK2D 6506.5


RUNX2 regulates bone development

RUNX2 regulates bone development
811
set RUNX2 regulates bone development
setSize 17
pANOVA 0.00253
s.dist -0.423
p.adjustANOVA 0.0861



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL1A1 -3049.5
SATB2 -3016.5
MAPK1 -2100.5
MAF -2089.5
MAPK3 -1898.5
HDAC3 -1869.5
CBFB -1581.5
SRC -960.5
ABL1 -636.5
RUNX2 -591.5
SMAD1 0.5
HEY2 0.5
YES1 0.5
HDAC4 936.5
RBM14 3736.5
RB1 5174.5
SMAD6 5490.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 -3049.5
SATB2 -3016.5
MAPK1 -2100.5
MAF -2089.5
MAPK3 -1898.5
HDAC3 -1869.5
CBFB -1581.5
SRC -960.5
ABL1 -636.5
RUNX2 -591.5
SMAD1 0.5
HEY2 0.5
YES1 0.5
HDAC4 936.5
RBM14 3736.5
RB1 5174.5
SMAD6 5490.5


Glycogen storage diseases

Glycogen storage diseases
384
set Glycogen storage diseases
setSize 10
pANOVA 0.0219
s.dist -0.418
p.adjustANOVA 0.236



Top enriched genes

Top 20 genes
GeneID Gene Rank
NHLRC1 -3113.5
GAA -2232.5
SLC37A4 -1738.5
UBC -1150.5
UBB -759.5
G6PC3 0.5
RPS27A 759.5
GYS1 1609.0
UBA52 2326.5
GYG1 3078.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NHLRC1 -3113.5
GAA -2232.5
SLC37A4 -1738.5
UBC -1150.5
UBB -759.5
G6PC3 0.5
RPS27A 759.5
GYS1 1609.0
UBA52 2326.5
GYG1 3078.5


Ras activation upon Ca2+ influx through NMDA receptor

Ras activation upon Ca2+ influx through NMDA receptor
817
set Ras activation upon Ca2+ influx through NMDA receptor
setSize 10
pANOVA 0.0273
s.dist -0.403
p.adjustANOVA 0.245



Top enriched genes

Top 20 genes
GeneID Gene Rank
DLG4 -2233.5
HRAS -2214.5
GRIN1 -1884.5
CAMK2G -1756.5
DLG1 -938.5
CALM1 -730.5
KRAS 0.5
GRIN2D 0.5
DLG2 2819.5
CAMK2D 6506.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLG4 -2233.5
HRAS -2214.5
GRIN1 -1884.5
CAMK2G -1756.5
DLG1 -938.5
CALM1 -730.5
KRAS 0.5
GRIN2D 0.5
DLG2 2819.5
CAMK2D 6506.5


TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
1053
set TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
setSize 10
pANOVA 0.0296
s.dist 0.397
p.adjustANOVA 0.247



Top enriched genes

Top 20 genes
GeneID Gene Rank
LTA 7190.5
TRAF2 6559.5
MAP3K14 6503.5
BIRC2 5397.5
TNFSF13B 4242.5
LTB 4157.5
TNFSF14 3919.5
TNFRSF12A 1489.5
BIRC3 1338.5
TRAF3 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LTA 7190.5
TRAF2 6559.5
MAP3K14 6503.5
BIRC2 5397.5
TNFSF13B 4242.5
LTB 4157.5
TNFSF14 3919.5
TNFRSF12A 1489.5
BIRC3 1338.5
TRAF3 0.5


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1034
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 10
pANOVA 0.0334
s.dist -0.388
p.adjustANOVA 0.26



Top enriched genes

Top 20 genes
GeneID Gene Rank
LTC4S -3024.5
DPEP2 -2574.5
ALOX5 -2511.5
GGT1 -2500.5
PTGR1 -2332.5
ALOX5AP 0.5
ABCC1 946.5
MAPKAPK2 2344.5
LTA4H 4840.5
CYP4F22 5134.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LTC4S -3024.5
DPEP2 -2574.5
ALOX5 -2511.5
GGT1 -2500.5
PTGR1 -2332.5
ALOX5AP 0.5
ABCC1 946.5
MAPKAPK2 2344.5
LTA4H 4840.5
CYP4F22 5134.5


Regulation of KIT signaling

Regulation of KIT signaling
835
set Regulation of KIT signaling
setSize 10
pANOVA 0.035
s.dist 0.385
p.adjustANOVA 0.264



Top enriched genes

Top 20 genes
GeneID Gene Rank
LCK 7188.5
SH2B3 7069.5
FYN 7012.5
CBL 5685.5
PTPN6 5311.5
SOCS1 4142.5
PRKCA 3492.5
GRB2 1224.5
YES1 0.5
SRC -960.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LCK 7188.5
SH2B3 7069.5
FYN 7012.5
CBL 5685.5
PTPN6 5311.5
SOCS1 4142.5
PRKCA 3492.5
GRB2 1224.5
YES1 0.5
SRC -960.5


CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
102
set CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
setSize 16
pANOVA 0.00852
s.dist -0.38
p.adjustANOVA 0.145



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS6KA1 -2359.5
DLG4 -2233.5
HRAS -2214.5
MAPK1 -2100.5
MAPK3 -1898.5
GRIN1 -1884.5
CAMK2G -1756.5
DLG1 -938.5
CALM1 -730.5
KRAS 0.5
CREB1 0.5
GRIN2D 0.5
DLG2 2819.5
PDPK1 3609.5
RPS6KA2 4422.5
CAMK2D 6506.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS6KA1 -2359.5
DLG4 -2233.5
HRAS -2214.5
MAPK1 -2100.5
MAPK3 -1898.5
GRIN1 -1884.5
CAMK2G -1756.5
DLG1 -938.5
CALM1 -730.5
KRAS 0.5
CREB1 0.5
GRIN2D 0.5
DLG2 2819.5
PDPK1 3609.5
RPS6KA2 4422.5
CAMK2D 6506.5


Purine catabolism

Purine catabolism
735
set Purine catabolism
setSize 10
pANOVA 0.0403
s.dist 0.374
p.adjustANOVA 0.281



Top enriched genes

Top 20 genes
GeneID Gene Rank
PNP 6872.5
NUDT15 6697.5
NUDT18 6513.5
NUDT5 5439.5
NT5C 5181.5
NT5C2 3361.5
NUDT9 3153.5
NUDT1 3114.0
ITPA 1350.5
NUDT16 -2058.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PNP 6872.5
NUDT15 6697.5
NUDT18 6513.5
NUDT5 5439.5
NT5C 5181.5
NT5C2 3361.5
NUDT9 3153.5
NUDT1 3114.0
ITPA 1350.5
NUDT16 -2058.5


Synaptic adhesion-like molecules

Synaptic adhesion-like molecules
1029
set Synaptic adhesion-like molecules
setSize 10
pANOVA 0.0423
s.dist -0.371
p.adjustANOVA 0.283



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRIN2C -2550.5
DLG4 -2233.5
FLOT1 -1952.5
GRIN1 -1884.5
DLG1 -938.5
GRIN2D 0.5
RTN3 620.5
LRFN4 1872.5
FLOT2 3639.5
LRFN3 4660.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRIN2C -2550.5
DLG4 -2233.5
FLOT1 -1952.5
GRIN1 -1884.5
DLG1 -938.5
GRIN2D 0.5
RTN3 620.5
LRFN4 1872.5
FLOT2 3639.5
LRFN3 4660.5


Class I peroxisomal membrane protein import

Class I peroxisomal membrane protein import
153
set Class I peroxisomal membrane protein import
setSize 18
pANOVA 0.00647
s.dist 0.371
p.adjustANOVA 0.133



Top enriched genes

Top 20 genes
GeneID Gene Rank
PEX12 6938.5
PEX19 6814.5
SLC25A17 6189.5
ALDH3A2 6154.5
PEX16 6019.5
PEX3 5678.0
PEX11B 5616.0
PEX13 5516.0
ATAD1 5259.0
PEX14 4380.5
PEX26 4152.5
ABCD3 4148.5
ABCD2 3557.5
PXMP2 2961.0
FIS1 2517.5
PXMP4 -1026.5
ACBD5 -1507.5
GDAP1 -2413.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PEX12 6938.5
PEX19 6814.5
SLC25A17 6189.5
ALDH3A2 6154.5
PEX16 6019.5
PEX3 5678.0
PEX11B 5616.0
PEX13 5516.0
ATAD1 5259.0
PEX14 4380.5
PEX26 4152.5
ABCD3 4148.5
ABCD2 3557.5
PXMP2 2961.0
FIS1 2517.5
PXMP4 -1026.5
ACBD5 -1507.5
GDAP1 -2413.5


Assembly and cell surface presentation of NMDA receptors

Assembly and cell surface presentation of NMDA receptors
64
set Assembly and cell surface presentation of NMDA receptors
setSize 13
pANOVA 0.0232
s.dist -0.363
p.adjustANOVA 0.238



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRIN2C -2550.5
DLG4 -2233.5
APBA1 -2019.5
NBEA -1930.5
GRIN1 -1884.5
CAMK2G -1756.5
LIN7B -991.5
DLG1 -938.5
GRIN2D 0.5
KIF17 1967.5
DLG2 2819.5
LIN7C 5109.0
CAMK2D 6506.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRIN2C -2550.5
DLG4 -2233.5
APBA1 -2019.5
NBEA -1930.5
GRIN1 -1884.5
CAMK2G -1756.5
LIN7B -991.5
DLG1 -938.5
GRIN2D 0.5
KIF17 1967.5
DLG2 2819.5
LIN7C 5109.0
CAMK2D 6506.5


Signaling by Hippo

Signaling by Hippo
972
set Signaling by Hippo
setSize 11
pANOVA 0.039
s.dist -0.359
p.adjustANOVA 0.281



Top enriched genes

Top 20 genes
GeneID Gene Rank
YWHAE -2505.5
LATS2 -2066.5
SAV1 -2060.5
LATS1 -2050.5
STK4 -1186.5
DVL2 -578.5
NPHP4 0.5
TJP2 503.5
CASP3 1673.0
YWHAB 3617.5
STK3 6660.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YWHAE -2505.5
LATS2 -2066.5
SAV1 -2060.5
LATS1 -2050.5
STK4 -1186.5
DVL2 -578.5
NPHP4 0.5
TJP2 503.5
CASP3 1673.0
YWHAB 3617.5
STK3 6660.5


Cell-cell junction organization

Cell-cell junction organization
130
set Cell-cell junction organization
setSize 12
pANOVA 0.0333
s.dist -0.355
p.adjustANOVA 0.26



Top enriched genes

Top 20 genes
GeneID Gene Rank
F11R -2581.5
MPP5 -2141.5
CDH24 -2124.5
CLDN12 -1720.5
CTNNB1 -1282.5
CTNND1 0.5
SDK2 0.5
PRKCI 1714.5
CLDN1 1954.5
PARD6A 2560.0
PARD6B 2676.5
ANG 3418.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F11R -2581.5
MPP5 -2141.5
CDH24 -2124.5
CLDN12 -1720.5
CTNNB1 -1282.5
CTNND1 0.5
SDK2 0.5
PRKCI 1714.5
CLDN1 1954.5
PARD6A 2560.0
PARD6B 2676.5
ANG 3418.0


Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand
119
set Caspase activation via Death Receptors in the presence of ligand
setSize 10
pANOVA 0.0546
s.dist 0.351
p.adjustANOVA 0.312



Top enriched genes

Top 20 genes
GeneID Gene Rank
CFLAR 6851.5
CASP8 6625.5
TRAF2 6559.5
TRADD 6244.0
TICAM1 4987.5
FAS 4179.0
TNFRSF10B 3315.5
TNFSF10 2395.5
TNFRSF10A 0.5
FADD -2742.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CFLAR 6851.5
CASP8 6625.5
TRAF2 6559.5
TRADD 6244.0
TICAM1 4987.5
FAS 4179.0
TNFRSF10B 3315.5
TNFSF10 2395.5
TNFRSF10A 0.5
FADD -2742.5


Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine
221
set Degradation of cysteine and homocysteine
setSize 10
pANOVA 0.0573
s.dist -0.347
p.adjustANOVA 0.321



Top enriched genes

Top 20 genes
GeneID Gene Rank
TXN2 -2579.5
TSTD1 -2220.5
ETHE1 -1964.5
MPST -1906.0
TST -1906.0
GOT2 -1326.5
CSAD 1538.0
SQRDL 2542.5
CTH 4092.5
ADO 6179.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TXN2 -2579.5
TSTD1 -2220.5
ETHE1 -1964.5
MPST -1906.0
TST -1906.0
GOT2 -1326.5
CSAD 1538.0
SQRDL 2542.5
CTH 4092.5
ADO 6179.5


Gastrin-CREB signalling pathway via PKC and MAPK

Gastrin-CREB signalling pathway via PKC and MAPK
367
set Gastrin-CREB signalling pathway via PKC and MAPK
setSize 11
pANOVA 0.0477
s.dist -0.345
p.adjustANOVA 0.299



Top enriched genes

Top 20 genes
GeneID Gene Rank
HBEGF -2841.5
RPS6KA1 -2359.5
HRAS -2214.5
MAPK1 -2100.5
MAPK3 -1898.5
KRAS 0.5
CREB1 0.5
GRB2 1224.5
PRKCA 3492.5
RPS6KA2 4422.5
MAPK7 5103.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HBEGF -2841.5
RPS6KA1 -2359.5
HRAS -2214.5
MAPK1 -2100.5
MAPK3 -1898.5
KRAS 0.5
CREB1 0.5
GRB2 1224.5
PRKCA 3492.5
RPS6KA2 4422.5
MAPK7 5103.5


SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy
892
set SARS-CoV-2 modulates autophagy
setSize 11
pANOVA 0.0507
s.dist 0.34
p.adjustANOVA 0.305



Top enriched genes

Top 20 genes
GeneID Gene Rank
UVRAG 7162.5
VPS16 7008.0
VPS39 6378.5
VPS11 5765.5
TUFM 4632.5
MAP1LC3B 4083.5
VPS33B 3798.5
VPS45 3521.5
VPS18 2469.5
VPS33A -784.5
VPS41 -2387.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UVRAG 7162.5
VPS16 7008.0
VPS39 6378.5
VPS11 5765.5
TUFM 4632.5
MAP1LC3B 4083.5
VPS33B 3798.5
VPS45 3521.5
VPS18 2469.5
VPS33A -784.5
VPS41 -2387.5


NOTCH4 Intracellular Domain Regulates Transcription

NOTCH4 Intracellular Domain Regulates Transcription
598
set NOTCH4 Intracellular Domain Regulates Transcription
setSize 14
pANOVA 0.0287
s.dist 0.338
p.adjustANOVA 0.247



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH4 6823.5
SMAD3 6606.5
NOTCH1 6546.5
RBPJ 5433.5
EP300 5031.5
SNW1 4685.0
MAML1 4626.5
ACTA2 4179.0
MAML3 3119.5
KAT2B 2854.5
KAT2A 2000.5
MAML2 903.5
HEY2 0.5
CREBBP 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH4 6823.5
SMAD3 6606.5
NOTCH1 6546.5
RBPJ 5433.5
EP300 5031.5
SNW1 4685.0
MAML1 4626.5
ACTA2 4179.0
MAML3 3119.5
KAT2B 2854.5
KAT2A 2000.5
MAML2 903.5
HEY2 0.5
CREBBP 0.5


TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
1066
set TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
setSize 16
pANOVA 0.0211
s.dist 0.333
p.adjustANOVA 0.229



Top enriched genes

Top 20 genes
GeneID Gene Rank
CNOT4 7117.5
PLK3 7090.5
CENPJ 6944.5
BTG2 6562.5
TP53 6276.0
PLK2 4871.5
CNOT6L 4374.5
CDC25C 4156.5
CNOT10 3255.5
CNOT3 3169.5
CNOT8 2744.5
CNOT7 1626.0
PLAGL1 1176.5
TNKS1BP1 888.5
CNOT1 884.5
CNOT6 -1158.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CNOT4 7117.5
PLK3 7090.5
CENPJ 6944.5
BTG2 6562.5
TP53 6276.0
PLK2 4871.5
CNOT6L 4374.5
CDC25C 4156.5
CNOT10 3255.5
CNOT3 3169.5
CNOT8 2744.5
CNOT7 1626.0
PLAGL1 1176.5
TNKS1BP1 888.5
CNOT1 884.5
CNOT6 -1158.5


RUNX3 regulates NOTCH signaling

RUNX3 regulates NOTCH signaling
813
set RUNX3 regulates NOTCH signaling
setSize 11
pANOVA 0.0581
s.dist 0.33
p.adjustANOVA 0.323



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH1 6546.5
RUNX3 5866.5
RBPJ 5433.5
EP300 5031.5
SNW1 4685.0
MAML1 4626.5
MAML3 3119.5
KAT2B 2854.5
KAT2A 2000.5
MAML2 903.5
CREBBP 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH1 6546.5
RUNX3 5866.5
RBPJ 5433.5
EP300 5031.5
SNW1 4685.0
MAML1 4626.5
MAML3 3119.5
KAT2B 2854.5
KAT2A 2000.5
MAML2 903.5
CREBBP 0.5


Potassium Channels

Potassium Channels
713
set Potassium Channels
setSize 26
pANOVA 0.00363
s.dist -0.33
p.adjustANOVA 0.106



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK6 -3011.5
KCNS1 -2978.5
KCNH4 -2826.5
KCNQ1 -2806.0
KCNQ5 -2456.5
KCNMB4 -1890.5
GABBR1 -1610.5
KCNAB2 -1568.5
GNB1 -1307.5
GNB4 -1252.5
KCNC4 0.5
KCNG3 0.5
GNG12 0.5
KCNH2 0.5
GNGT2 0.5
KCNJ11 860.5
KCNQ4 1090.5
GNG4 1378.5
GNG5 1544.0
HCN3 1610.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK6 -3011.5
KCNS1 -2978.5
KCNH4 -2826.5
KCNQ1 -2806.0
KCNQ5 -2456.5
KCNMB4 -1890.5
GABBR1 -1610.5
KCNAB2 -1568.5
GNB1 -1307.5
GNB4 -1252.5
KCNC4 0.5
KCNG3 0.5
GNG12 0.5
KCNH2 0.5
GNGT2 0.5
KCNJ11 860.5
KCNQ4 1090.5
GNG4 1378.5
GNG5 1544.0
HCN3 1610.5
KCNN4 1791.5
GNG2 2385.5
GNB5 2733.5
GNG3 4284.5
GNB2 6046.5
KCNA3 6769.5


Leading Strand Synthesis

Leading Strand Synthesis
503
set Leading Strand Synthesis
setSize 12
pANOVA 0.0495
s.dist 0.327
p.adjustANOVA 0.3



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRIM1 6923.5
POLD1 6531.5
RFC5 6225.5
RFC3 5827.5
RFC4 5458.5
PRIM2 5131.5
POLD4 4972.5
POLA2 3956.5
POLD3 3647.5
PCNA -693.5
POLD2 -1204.5
RFC2 -2131.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRIM1 6923.5
POLD1 6531.5
RFC5 6225.5
RFC3 5827.5
RFC4 5458.5
PRIM2 5131.5
POLD4 4972.5
POLA2 3956.5
POLD3 3647.5
PCNA -693.5
POLD2 -1204.5
RFC2 -2131.5


Polymerase switching

Polymerase switching
704
set Polymerase switching
setSize 12
pANOVA 0.0495
s.dist 0.327
p.adjustANOVA 0.3



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRIM1 6923.5
POLD1 6531.5
RFC5 6225.5
RFC3 5827.5
RFC4 5458.5
PRIM2 5131.5
POLD4 4972.5
POLA2 3956.5
POLD3 3647.5
PCNA -693.5
POLD2 -1204.5
RFC2 -2131.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRIM1 6923.5
POLD1 6531.5
RFC5 6225.5
RFC3 5827.5
RFC4 5458.5
PRIM2 5131.5
POLD4 4972.5
POLA2 3956.5
POLD3 3647.5
PCNA -693.5
POLD2 -1204.5
RFC2 -2131.5


mRNA decay by 3’ to 5’ exoribonuclease

mRNA decay by 3’ to 5’ exoribonuclease
1175
set mRNA decay by 3’ to 5’ exoribonuclease
setSize 14
pANOVA 0.0361
s.dist 0.323
p.adjustANOVA 0.268



Top enriched genes

Top 20 genes
GeneID Gene Rank
EXOSC8 6532.5
DIS3 6495.0
TTC37 6365.0
WDR61 5590.5
HBS1L 4774.5
EXOSC7 4446.0
DCPS 4198.5
EXOSC4 3970.5
SKIV2L 3282.0
EXOSC2 3110.5
EXOSC5 2336.0
EXOSC3 1535.5
EXOSC6 542.5
EXOSC1 -1392.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC8 6532.5
DIS3 6495.0
TTC37 6365.0
WDR61 5590.5
HBS1L 4774.5
EXOSC7 4446.0
DCPS 4198.5
EXOSC4 3970.5
SKIV2L 3282.0
EXOSC2 3110.5
EXOSC5 2336.0
EXOSC3 1535.5
EXOSC6 542.5
EXOSC1 -1392.0


Heparan sulfate/heparin (HS-GAG) metabolism

Heparan sulfate/heparin (HS-GAG) metabolism
418
set Heparan sulfate/heparin (HS-GAG) metabolism
setSize 22
pANOVA 0.00889
s.dist -0.322
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
B3GAT2 -2982.5
B4GALT7 -2710.5
SDC4 -2692.5
XYLT1 -2258.5
NAGLU -1491.5
GLB1 -1468.0
GUSB -1433.5
IDUA -1266.0
HS6ST1 -1250.5
BCAN -1170.5
EXT2 -1062.5
HS3ST3B1 -912.5
HPSE2 0.5
EXT1 558.5
GPC2 627.0
SGSH 2006.0
NDST2 2124.5
B3GALT6 2174.0
GLCE 2804.0
AGRN 4937.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3GAT2 -2982.5
B4GALT7 -2710.5
SDC4 -2692.5
XYLT1 -2258.5
NAGLU -1491.5
GLB1 -1468.0
GUSB -1433.5
IDUA -1266.0
HS6ST1 -1250.5
BCAN -1170.5
EXT2 -1062.5
HS3ST3B1 -912.5
HPSE2 0.5
EXT1 558.5
GPC2 627.0
SGSH 2006.0
NDST2 2124.5
B3GALT6 2174.0
GLCE 2804.0
AGRN 4937.5
XYLT2 6721.5
B3GAT3 7000.5


Mucopolysaccharidoses

Mucopolysaccharidoses
578
set Mucopolysaccharidoses
setSize 10
pANOVA 0.0809
s.dist -0.319
p.adjustANOVA 0.375



Top enriched genes

Top 20 genes
GeneID Gene Rank
NAGLU -1491.5
GLB1 -1468.0
GUSB -1433.5
IDUA -1266.0
ARSB -1012.5
HYAL1 0.5
GALNS 1340.0
SGSH 2006.0
GNS 3478.5
HGSNAT 3759.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NAGLU -1491.5
GLB1 -1468.0
GUSB -1433.5
IDUA -1266.0
ARSB -1012.5
HYAL1 0.5
GALNS 1340.0
SGSH 2006.0
GNS 3478.5
HGSNAT 3759.5


Arachidonic acid metabolism

Arachidonic acid metabolism
61
set Arachidonic acid metabolism
setSize 21
pANOVA 0.0122
s.dist -0.316
p.adjustANOVA 0.17



Top enriched genes

Top 20 genes
GeneID Gene Rank
LTC4S -3024.5
TBXAS1 -2619.5
DPEP2 -2574.5
ALOX5 -2511.5
GGT1 -2500.5
PTGR1 -2332.5
EPHX2 -2264.5
HPGD -1600.5
PON2 -1276.5
PTGR2 -1124.5
GPX1 0.5
ALOX5AP 0.5
CYP2U1 0.5
ALOXE3 637.5
ABCC1 946.5
MAPKAPK2 2344.5
GPX4 3488.5
LTA4H 4840.5
CYP4F22 5134.5
PTGES2 5886.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LTC4S -3024.5
TBXAS1 -2619.5
DPEP2 -2574.5
ALOX5 -2511.5
GGT1 -2500.5
PTGR1 -2332.5
EPHX2 -2264.5
HPGD -1600.5
PON2 -1276.5
PTGR2 -1124.5
GPX1 0.5
ALOX5AP 0.5
CYP2U1 0.5
ALOXE3 637.5
ABCC1 946.5
MAPKAPK2 2344.5
GPX4 3488.5
LTA4H 4840.5
CYP4F22 5134.5
PTGES2 5886.0
PTGES3 7088.5


Triglyceride catabolism

Triglyceride catabolism
1138
set Triglyceride catabolism
setSize 11
pANOVA 0.0705
s.dist -0.315
p.adjustANOVA 0.343



Top enriched genes

Top 20 genes
GeneID Gene Rank
GPD2 -2825.5
ABHD5 -2549.5
PRKACA -1900.5
PPP1CB -1620.5
PLIN3 -905.5
PPP1CC 746.5
PPP1CA 862.5
LIPE 1070.5
FABP5 1514.5
PRKACB 3457.5
CAV1 6670.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPD2 -2825.5
ABHD5 -2549.5
PRKACA -1900.5
PPP1CB -1620.5
PLIN3 -905.5
PPP1CC 746.5
PPP1CA 862.5
LIPE 1070.5
FABP5 1514.5
PRKACB 3457.5
CAV1 6670.5


STING mediated induction of host immune responses

STING mediated induction of host immune responses
905
set STING mediated induction of host immune responses
setSize 10
pANOVA 0.0883
s.dist -0.311
p.adjustANOVA 0.375



Top enriched genes

Top 20 genes
GeneID Gene Rank
TREX1 -2563.5
XRCC6 -1940.0
TRIM21 -1321.5
STAT6 -1239.5
IRF3 1327.0
DTX4 1629.5
XRCC5 1787.5
PRKDC 1830.0
DDX41 1951.5
TBK1 2839.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TREX1 -2563.5
XRCC6 -1940.0
TRIM21 -1321.5
STAT6 -1239.5
IRF3 1327.0
DTX4 1629.5
XRCC5 1787.5
PRKDC 1830.0
DDX41 1951.5
TBK1 2839.5


Rap1 signalling

Rap1 signalling
816
set Rap1 signalling
setSize 11
pANOVA 0.0765
s.dist 0.308
p.adjustANOVA 0.362



Top enriched genes

Top 20 genes
GeneID Gene Rank
YWHAZ 7122.5
RAP1A 6705.5
RAP1B 6500.5
RASGRP1 4429.5
YWHAB 3617.5
PRKACB 3457.5
RAF1 3305.5
SIPA1 2974.5
RASGRP2 1940.5
RAP1GAP2 1691.5
PRKACA -1900.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YWHAZ 7122.5
RAP1A 6705.5
RAP1B 6500.5
RASGRP1 4429.5
YWHAB 3617.5
PRKACB 3457.5
RAF1 3305.5
SIPA1 2974.5
RASGRP2 1940.5
RAP1GAP2 1691.5
PRKACA -1900.5


Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs
724
set Processing of Intronless Pre-mRNAs
setSize 15
pANOVA 0.0388
s.dist 0.308
p.adjustANOVA 0.281



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 6538.0
NUDT21 6498.0
CSTF1 6459.0
CPSF4 5462.0
CPSF2 5140.0
CLP1 4722.5
WDR33 3344.5
CPSF6 3239.5
PABPN1 3193.5
NCBP2 2447.0
FIP1L1 2354.5
CPSF1 1547.5
CPSF3 1363.0
SYMPK 1072.5
PAPOLA 928.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 6538.0
NUDT21 6498.0
CSTF1 6459.0
CPSF4 5462.0
CPSF2 5140.0
CLP1 4722.5
WDR33 3344.5
CPSF6 3239.5
PABPN1 3193.5
NCBP2 2447.0
FIP1L1 2354.5
CPSF1 1547.5
CPSF3 1363.0
SYMPK 1072.5
PAPOLA 928.5


RHO GTPases activate CIT

RHO GTPases activate CIT
758
set RHO GTPases activate CIT
setSize 14
pANOVA 0.0496
s.dist 0.303
p.adjustANOVA 0.3



Top enriched genes

Top 20 genes
GeneID Gene Rank
CIT 6951.5
RHOB 6666.5
PPP1R12A 6450.5
KIF14 5548.5
MYH9 5448.5
MYL6 5389.5
CDKN1B 5388.5
RHOA 4771.0
PPP1R12B 4546.5
MYH10 2703.5
RAC1 1104.5
PRC1 -792.5
PPP1CB -1620.5
DLG4 -2233.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CIT 6951.5
RHOB 6666.5
PPP1R12A 6450.5
KIF14 5548.5
MYH9 5448.5
MYL6 5389.5
CDKN1B 5388.5
RHOA 4771.0
PPP1R12B 4546.5
MYH10 2703.5
RAC1 1104.5
PRC1 -792.5
PPP1CB -1620.5
DLG4 -2233.5


Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
1140
set Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
setSize 15
pANOVA 0.0434
s.dist 0.301
p.adjustANOVA 0.286



Top enriched genes

Top 20 genes
GeneID Gene Rank
EXOSC8 6532.5
DIS3 6495.0
TNPO1 6058.5
DCP2 5890.5
ZFP36 5773.5
EXOSC7 4446.0
EXOSC4 3970.5
YWHAB 3617.5
EXOSC2 3110.5
DCP1A 2507.5
MAPKAPK2 2344.5
EXOSC5 2336.0
EXOSC3 1535.5
EXOSC6 542.5
EXOSC1 -1392.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC8 6532.5
DIS3 6495.0
TNPO1 6058.5
DCP2 5890.5
ZFP36 5773.5
EXOSC7 4446.0
EXOSC4 3970.5
YWHAB 3617.5
EXOSC2 3110.5
DCP1A 2507.5
MAPKAPK2 2344.5
EXOSC5 2336.0
EXOSC3 1535.5
EXOSC6 542.5
EXOSC1 -1392.0


Josephin domain DUBs

Josephin domain DUBs
491
set Josephin domain DUBs
setSize 11
pANOVA 0.0845
s.dist -0.3
p.adjustANOVA 0.375



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD23A -2240.5
PARK2 -2181.0
UBC -1150.5
VCP -1134.5
UBB -759.5
JOSD2 -583.5
RPS27A 759.5
JOSD1 1411.5
UBA52 2326.5
ATXN3 3481.5
RAD23B 5416.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD23A -2240.5
PARK2 -2181.0
UBC -1150.5
VCP -1134.5
UBB -759.5
JOSD2 -583.5
RPS27A 759.5
JOSD1 1411.5
UBA52 2326.5
ATXN3 3481.5
RAD23B 5416.5


Transcriptional regulation of granulopoiesis

Transcriptional regulation of granulopoiesis
1112
set Transcriptional regulation of granulopoiesis
setSize 24
pANOVA 0.0109
s.dist -0.3
p.adjustANOVA 0.162



Top enriched genes

Top 20 genes
GeneID Gene Rank
SPI1 -3114.5
CEBPE -3094.5
CEBPA -2827.5
CSF3R -2702.5
TFDP1 -2179.5
IL6R -1698.5
RARA -1605.5
CBFB -1581.5
H2AFX -1571.5
RUNX1 -1540.5
DEK -1480.5
KLF5 -676.5
CREB1 0.5
CDKN1A 0.5
CDK2 1826.0
CDK4 1926.5
E2F1 1992.5
FLI1 2126.5
STAT3 2532.5
MYB 3698.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SPI1 -3114.5
CEBPE -3094.5
CEBPA -2827.5
CSF3R -2702.5
TFDP1 -2179.5
IL6R -1698.5
RARA -1605.5
CBFB -1581.5
H2AFX -1571.5
RUNX1 -1540.5
DEK -1480.5
KLF5 -676.5
CREB1 0.5
CDKN1A 0.5
CDK2 1826.0
CDK4 1926.5
E2F1 1992.5
FLI1 2126.5
STAT3 2532.5
MYB 3698.5
GFI1 4968.5
EP300 5031.5
CEBPB 5379.5
PML 6318.5


E2F mediated regulation of DNA replication

E2F mediated regulation of DNA replication
265
set E2F mediated regulation of DNA replication
setSize 12
pANOVA 0.0758
s.dist 0.296
p.adjustANOVA 0.362



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRIM1 6923.5
CCNB1 6075.5
PPP2CA 5524.5
RB1 5174.5
PRIM2 5131.5
PPP2CB 4601.5
POLA2 3956.5
MCM8 3343.0
CDK1 2828.0
E2F1 1992.5
PPP2R1B -675.5
TFDP1 -2179.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRIM1 6923.5
CCNB1 6075.5
PPP2CA 5524.5
RB1 5174.5
PRIM2 5131.5
PPP2CB 4601.5
POLA2 3956.5
MCM8 3343.0
CDK1 2828.0
E2F1 1992.5
PPP2R1B -675.5
TFDP1 -2179.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.2.4    GGally_2.1.2     ggplot2_3.3.5    reshape2_1.4.4  
##  [5] beeswarm_0.4.0   gplots_3.1.1     gtools_3.9.2     tibble_3.1.6    
##  [9] echarts4r_0.4.3  mitch_1.4.1      eulerr_6.1.1     kableExtra_1.3.4
## [13] dplyr_1.0.8     
## 
## loaded via a namespace (and not attached):
##  [1] httr_1.4.2         sass_0.4.1         jsonlite_1.8.0     viridisLite_0.4.0 
##  [5] brio_1.1.3         bslib_0.3.1        shiny_1.7.1        assertthat_0.2.1  
##  [9] highr_0.9          yaml_2.3.5         pillar_1.7.0       glue_1.6.2        
## [13] digest_0.6.29      RColorBrewer_1.1-3 promises_1.2.0.1   rvest_1.0.2       
## [17] colorspace_2.0-3   htmltools_0.5.2    httpuv_1.6.5       plyr_1.8.7        
## [21] pkgconfig_2.0.3    purrr_0.3.4        xtable_1.8-4       scales_1.1.1      
## [25] webshot_0.5.2      svglite_2.1.0      later_1.3.0        generics_0.1.2    
## [29] ellipsis_0.3.2     withr_2.5.0        cli_3.2.0          magrittr_2.0.3    
## [33] crayon_1.5.1       mime_0.12          evaluate_0.15      fansi_1.0.3       
## [37] MASS_7.3-57        xml2_1.3.3         tools_4.2.0        lifecycle_1.0.1   
## [41] stringr_1.4.0      munsell_0.5.0      compiler_4.2.0     jquerylib_0.1.4   
## [45] caTools_1.18.2     systemfonts_1.0.4  rlang_1.0.2        grid_4.2.0        
## [49] rstudioapi_0.13    htmlwidgets_1.5.4  bitops_1.0-7       rmarkdown_2.13    
## [53] testthat_3.1.3     gtable_0.3.0       DBI_1.1.2          reshape_0.8.8     
## [57] R6_2.5.1           gridExtra_2.3      knitr_1.38         fastmap_1.1.0     
## [61] utf8_1.2.2         rprojroot_2.0.3    KernSmooth_2.23-20 desc_1.4.1        
## [65] stringi_1.7.6      Rcpp_1.0.8.3       vctrs_0.4.0        tidyselect_1.1.2  
## [69] xfun_0.30

END of report