Mitch Report

date generated: 2022-05-25

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##              meth       rna
## A1BG   1.24705218 -1.273246
## AAAS  -0.50714599  1.984100
## AACS  -0.23733060  5.024916
## AAED1 -0.01139772 -6.028496
## AAGAB  0.01084012  6.362228
## AAK1   0.04196131 -1.303366

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	9800
duplicated_genes_present	0
num_profile_genes_in_sets	5910
num_profile_genes_not_in_sets	3890
profile_pearson_correl	-0.03807
profile_spearman_correl	-0.08938

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ../ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1318
num_genesets_included	1228

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 495

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.meth	s.rna	p.meth	p.rna
Unwinding of DNA	11	8.50e-08	8.42e-07	1.020	-0.38500	0.946	0.02700	5.44e-08
Defective pyroptosis	12	1.34e-06	9.90e-06	0.850	0.15100	0.837	0.36500	5.18e-07
Condensation of Prometaphase Chromosomes	10	3.75e-05	2.06e-04	0.846	-0.28900	0.795	0.11400	1.34e-05
Activation of the pre-replicative complex	31	4.46e-14	1.30e-12	0.806	0.04690	0.804	0.65200	8.75e-15
DNA strand elongation	30	8.72e-12	2.02e-10	0.752	-0.02990	0.752	0.77700	1.02e-12
Endosomal/Vacuolar pathway	10	4.82e-04	2.07e-03	0.745	0.55600	-0.495	0.00233	6.70e-03
Mucopolysaccharidoses	11	8.30e-05	4.26e-04	0.743	-0.09810	-0.737	0.57300	2.33e-05
Activation of ATR in response to replication stress	36	2.11e-13	5.89e-12	0.741	-0.09680	0.735	0.31500	2.28e-14
Polo-like kinase mediated events	15	1.18e-05	7.25e-05	0.727	-0.23100	0.690	0.12200	3.74e-06
Deposition of new CENPA-containing nucleosomes at the centromere	22	3.41e-08	3.70e-07	0.720	-0.00931	0.720	0.94000	5.00e-09
Nucleosome assembly	22	3.41e-08	3.70e-07	0.720	-0.00931	0.720	0.94000	5.00e-09
G1/S-Specific Transcription	28	2.12e-09	2.99e-08	0.697	-0.11100	0.688	0.31100	2.90e-10
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.95e-04	9.12e-04	0.669	-0.10300	0.661	0.52200	3.72e-05
Condensation of Prophase Chromosomes	13	2.40e-04	1.10e-03	0.665	-0.15100	0.647	0.34700	5.32e-05
Assembly of the ORC complex at the origin of replication	10	1.42e-03	5.23e-03	0.662	-0.03510	0.661	0.84700	2.96e-04
Lagging Strand Synthesis	19	2.01e-06	1.44e-05	0.661	0.17600	0.637	0.18400	1.52e-06
Processive synthesis on the lagging strand	14	5.73e-05	3.02e-04	0.660	0.23800	0.616	0.12400	6.66e-05
Purine ribonucleoside monophosphate biosynthesis	10	1.55e-03	5.65e-03	0.654	0.00407	0.654	0.98200	3.43e-04
Sema4D induced cell migration and growth-cone collapse	12	9.66e-04	3.67e-03	0.648	0.42900	-0.486	0.01010	3.55e-03
Postmitotic nuclear pore complex (NPC) reformation	26	1.18e-07	1.15e-06	0.648	-0.11800	0.637	0.30000	1.88e-08
Cell-extracellular matrix interactions	11	1.47e-03	5.37e-03	0.644	0.20700	-0.610	0.23400	4.60e-04
PRC2 methylates histones and DNA	13	3.00e-04	1.33e-03	0.638	0.05370	0.636	0.73700	7.25e-05
Removal of the Flap Intermediate	13	2.45e-04	1.11e-03	0.635	0.19000	0.605	0.23500	1.57e-04
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	2.14e-03	7.58e-03	0.634	0.04560	0.632	0.80300	5.37e-04
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	22	1.31e-06	9.80e-06	0.633	0.05900	0.631	0.63200	3.07e-07
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	22	1.31e-06	9.80e-06	0.633	0.05900	0.631	0.63200	3.07e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	22	1.31e-06	9.80e-06	0.633	0.05900	0.631	0.63200	3.07e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	22	1.31e-06	9.80e-06	0.633	0.05900	0.631	0.63200	3.07e-07
Impaired BRCA2 binding to PALB2	22	1.31e-06	9.80e-06	0.633	0.05900	0.631	0.63200	3.07e-07
Interactions of Rev with host cellular proteins	34	3.32e-09	4.39e-08	0.631	-0.15900	0.610	0.10900	7.37e-10
Nucleotide biosynthesis	12	7.86e-04	3.09e-03	0.631	-0.02910	0.630	0.86200	1.58e-04
Cyclin A/B1/B2 associated events during G2/M transition	22	3.34e-06	2.21e-05	0.630	-0.15900	0.610	0.19600	7.47e-07
Rev-mediated nuclear export of HIV RNA	33	7.39e-09	9.17e-08	0.629	-0.17800	0.603	0.07690	2.07e-09
Leading Strand Synthesis	14	1.49e-04	7.13e-04	0.628	0.20700	0.593	0.18000	1.22e-04
Polymerase switching	14	1.49e-04	7.13e-04	0.628	0.20700	0.593	0.18000	1.22e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	21	2.22e-06	1.58e-05	0.627	0.15300	0.609	0.22600	1.38e-06
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	7.70e-07	6.11e-06	0.618	0.06030	0.615	0.60900	1.84e-07
Homologous DNA Pairing and Strand Exchange	39	3.20e-10	5.61e-09	0.616	-0.07490	0.612	0.41900	3.86e-11
PCNA-Dependent Long Patch Base Excision Repair	19	1.40e-05	8.41e-05	0.612	0.14500	0.594	0.27300	7.36e-06
Nuclear import of Rev protein	31	6.82e-08	7.04e-07	0.608	-0.16700	0.585	0.10700	1.75e-08
NEP/NS2 Interacts with the Cellular Export Machinery	30	1.51e-07	1.44e-06	0.605	-0.19000	0.575	0.07250	5.10e-08
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	37	2.20e-09	3.03e-08	0.604	-0.07350	0.600	0.43900	2.77e-10
Diseases of DNA Double-Strand Break Repair	37	2.20e-09	3.03e-08	0.604	-0.07350	0.600	0.43900	2.77e-10
Meiotic recombination	19	3.69e-05	2.03e-04	0.604	-0.08210	0.598	0.53600	6.38e-06
Vpr-mediated nuclear import of PICs	32	8.03e-08	8.08e-07	0.601	-0.22500	0.557	0.02780	5.02e-08
Transport of Ribonucleoproteins into the Host Nucleus	30	1.90e-07	1.76e-06	0.600	-0.18300	0.572	0.08300	5.98e-08
Presynaptic phase of homologous DNA pairing and strand exchange	36	6.03e-09	7.63e-08	0.596	-0.06470	0.593	0.50200	7.68e-10
Impaired BRCA2 binding to RAD51	32	5.54e-08	5.81e-07	0.595	-0.08000	0.590	0.43400	7.71e-09
Sema4D in semaphorin signaling	15	6.97e-04	2.84e-03	0.593	0.37800	-0.457	0.01130	2.19e-03
SUMOylation of DNA replication proteins	43	3.83e-10	6.62e-09	0.590	-0.12900	0.575	0.14500	6.74e-11

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.meth	s.rna	p.meth	p.rna
Unwinding of DNA	11	8.50e-08	8.42e-07	1.02000	-0.385000	0.946000	2.70e-02	5.44e-08
Defective pyroptosis	12	1.34e-06	9.90e-06	0.85000	0.151000	0.837000	3.65e-01	5.18e-07
Condensation of Prometaphase Chromosomes	10	3.75e-05	2.06e-04	0.84600	-0.289000	0.795000	1.14e-01	1.34e-05
Activation of the pre-replicative complex	31	4.46e-14	1.30e-12	0.80600	0.046900	0.804000	6.52e-01	8.75e-15
DNA strand elongation	30	8.72e-12	2.02e-10	0.75200	-0.029900	0.752000	7.77e-01	1.02e-12
Endosomal/Vacuolar pathway	10	4.82e-04	2.07e-03	0.74500	0.556000	-0.495000	2.33e-03	6.70e-03
Mucopolysaccharidoses	11	8.30e-05	4.26e-04	0.74300	-0.098100	-0.737000	5.73e-01	2.33e-05
Activation of ATR in response to replication stress	36	2.11e-13	5.89e-12	0.74100	-0.096800	0.735000	3.15e-01	2.28e-14
Polo-like kinase mediated events	15	1.18e-05	7.25e-05	0.72700	-0.231000	0.690000	1.22e-01	3.74e-06
Deposition of new CENPA-containing nucleosomes at the centromere	22	3.41e-08	3.70e-07	0.72000	-0.009310	0.720000	9.40e-01	5.00e-09
Nucleosome assembly	22	3.41e-08	3.70e-07	0.72000	-0.009310	0.720000	9.40e-01	5.00e-09
G1/S-Specific Transcription	28	2.12e-09	2.99e-08	0.69700	-0.111000	0.688000	3.11e-01	2.90e-10
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.95e-04	9.12e-04	0.66900	-0.103000	0.661000	5.22e-01	3.72e-05
Condensation of Prophase Chromosomes	13	2.40e-04	1.10e-03	0.66500	-0.151000	0.647000	3.47e-01	5.32e-05
Assembly of the ORC complex at the origin of replication	10	1.42e-03	5.23e-03	0.66200	-0.035100	0.661000	8.47e-01	2.96e-04
Lagging Strand Synthesis	19	2.01e-06	1.44e-05	0.66100	0.176000	0.637000	1.84e-01	1.52e-06
Processive synthesis on the lagging strand	14	5.73e-05	3.02e-04	0.66000	0.238000	0.616000	1.24e-01	6.66e-05
Purine ribonucleoside monophosphate biosynthesis	10	1.55e-03	5.65e-03	0.65400	0.004070	0.654000	9.82e-01	3.43e-04
Sema4D induced cell migration and growth-cone collapse	12	9.66e-04	3.67e-03	0.64800	0.429000	-0.486000	1.01e-02	3.55e-03
Postmitotic nuclear pore complex (NPC) reformation	26	1.18e-07	1.15e-06	0.64800	-0.118000	0.637000	3.00e-01	1.88e-08
Cell-extracellular matrix interactions	11	1.47e-03	5.37e-03	0.64400	0.207000	-0.610000	2.34e-01	4.60e-04
PRC2 methylates histones and DNA	13	3.00e-04	1.33e-03	0.63800	0.053700	0.636000	7.37e-01	7.25e-05
Removal of the Flap Intermediate	13	2.45e-04	1.11e-03	0.63500	0.190000	0.605000	2.35e-01	1.57e-04
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	2.14e-03	7.58e-03	0.63400	0.045600	0.632000	8.03e-01	5.37e-04
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	22	1.31e-06	9.80e-06	0.63300	0.059000	0.631000	6.32e-01	3.07e-07
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	22	1.31e-06	9.80e-06	0.63300	0.059000	0.631000	6.32e-01	3.07e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	22	1.31e-06	9.80e-06	0.63300	0.059000	0.631000	6.32e-01	3.07e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	22	1.31e-06	9.80e-06	0.63300	0.059000	0.631000	6.32e-01	3.07e-07
Impaired BRCA2 binding to PALB2	22	1.31e-06	9.80e-06	0.63300	0.059000	0.631000	6.32e-01	3.07e-07
Interactions of Rev with host cellular proteins	34	3.32e-09	4.39e-08	0.63100	-0.159000	0.610000	1.09e-01	7.37e-10
Nucleotide biosynthesis	12	7.86e-04	3.09e-03	0.63100	-0.029100	0.630000	8.62e-01	1.58e-04
Cyclin A/B1/B2 associated events during G2/M transition	22	3.34e-06	2.21e-05	0.63000	-0.159000	0.610000	1.96e-01	7.47e-07
Rev-mediated nuclear export of HIV RNA	33	7.39e-09	9.17e-08	0.62900	-0.178000	0.603000	7.69e-02	2.07e-09
Leading Strand Synthesis	14	1.49e-04	7.13e-04	0.62800	0.207000	0.593000	1.80e-01	1.22e-04
Polymerase switching	14	1.49e-04	7.13e-04	0.62800	0.207000	0.593000	1.80e-01	1.22e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	21	2.22e-06	1.58e-05	0.62700	0.153000	0.609000	2.26e-01	1.38e-06
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	7.70e-07	6.11e-06	0.61800	0.060300	0.615000	6.09e-01	1.84e-07
Homologous DNA Pairing and Strand Exchange	39	3.20e-10	5.61e-09	0.61600	-0.074900	0.612000	4.19e-01	3.86e-11
PCNA-Dependent Long Patch Base Excision Repair	19	1.40e-05	8.41e-05	0.61200	0.145000	0.594000	2.73e-01	7.36e-06
Nuclear import of Rev protein	31	6.82e-08	7.04e-07	0.60800	-0.167000	0.585000	1.07e-01	1.75e-08
NEP/NS2 Interacts with the Cellular Export Machinery	30	1.51e-07	1.44e-06	0.60500	-0.190000	0.575000	7.25e-02	5.10e-08
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	37	2.20e-09	3.03e-08	0.60400	-0.073500	0.600000	4.39e-01	2.77e-10
Diseases of DNA Double-Strand Break Repair	37	2.20e-09	3.03e-08	0.60400	-0.073500	0.600000	4.39e-01	2.77e-10
Meiotic recombination	19	3.69e-05	2.03e-04	0.60400	-0.082100	0.598000	5.36e-01	6.38e-06
Vpr-mediated nuclear import of PICs	32	8.03e-08	8.08e-07	0.60100	-0.225000	0.557000	2.78e-02	5.02e-08
Transport of Ribonucleoproteins into the Host Nucleus	30	1.90e-07	1.76e-06	0.60000	-0.183000	0.572000	8.30e-02	5.98e-08
Presynaptic phase of homologous DNA pairing and strand exchange	36	6.03e-09	7.63e-08	0.59600	-0.064700	0.593000	5.02e-01	7.68e-10
Impaired BRCA2 binding to RAD51	32	5.54e-08	5.81e-07	0.59500	-0.080000	0.590000	4.34e-01	7.71e-09
Sema4D in semaphorin signaling	15	6.97e-04	2.84e-03	0.59300	0.378000	-0.457000	1.13e-02	2.19e-03
SUMOylation of DNA replication proteins	43	3.83e-10	6.62e-09	0.59000	-0.129000	0.575000	1.45e-01	6.74e-11
rRNA modification in the nucleus and cytosol	50	2.17e-11	4.75e-10	0.58900	-0.221000	0.546000	6.87e-03	2.39e-11
Resolution of D-loop Structures through Holliday Junction Intermediates	28	5.07e-07	4.27e-06	0.58500	0.004320	0.585000	9.68e-01	8.37e-08
PKA activation	10	4.36e-03	1.39e-02	0.58500	-0.181000	-0.556000	3.20e-01	2.35e-03
Transport of the SLBP Dependant Mature mRNA	34	7.50e-08	7.65e-07	0.58400	-0.220000	0.541000	2.66e-02	4.82e-08
Export of Viral Ribonucleoproteins from Nucleus	31	2.44e-07	2.20e-06	0.58400	-0.151000	0.564000	1.46e-01	5.59e-08
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	28	1.26e-06	9.75e-06	0.58300	-0.189000	0.552000	8.32e-02	4.40e-07
Regulation of Glucokinase by Glucokinase Regulatory Protein	28	1.26e-06	9.75e-06	0.58300	-0.189000	0.552000	8.32e-02	4.40e-07
HS-GAG degradation	10	5.56e-03	1.67e-02	0.58200	-0.050400	-0.580000	7.82e-01	1.51e-03
Metabolism of non-coding RNA	49	3.52e-11	7.45e-10	0.58200	-0.123000	0.568000	1.35e-01	5.91e-12
snRNP Assembly	49	3.52e-11	7.45e-10	0.58200	-0.123000	0.568000	1.35e-01	5.91e-12
E2F mediated regulation of DNA replication	20	3.49e-05	1.95e-04	0.58100	0.017200	0.581000	8.94e-01	6.84e-06
Transport of the SLBP independent Mature mRNA	33	1.59e-07	1.50e-06	0.57900	-0.219000	0.536000	2.97e-02	9.90e-08
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	2.37e-03	8.21e-03	0.57600	0.018900	0.576000	9.10e-01	5.57e-04
Processing of Capped Intronless Pre-mRNA	24	5.14e-06	3.27e-05	0.57500	0.057800	0.572000	6.24e-01	1.25e-06
Resolution of D-Loop Structures	29	5.94e-07	4.92e-06	0.57200	0.002340	0.572000	9.83e-01	9.74e-08
Mitotic Telophase/Cytokinesis	11	4.54e-03	1.44e-02	0.57200	-0.024600	0.571000	8.88e-01	1.03e-03
Diseases of DNA repair	45	5.71e-10	9.61e-09	0.56600	-0.069500	0.562000	4.20e-01	7.00e-11
G2/M Checkpoints	122	1.02e-25	1.14e-23	0.56600	-0.057500	0.563000	2.74e-01	7.56e-27
Nicotinamide salvaging	10	5.29e-03	1.62e-02	0.56500	-0.453000	-0.338000	1.31e-02	6.45e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	41	8.38e-09	1.01e-07	0.56300	-0.170000	0.537000	5.97e-02	2.76e-09
Hyaluronan uptake and degradation	10	1.10e-02	2.95e-02	0.56300	0.195000	-0.528000	2.85e-01	3.85e-03
Resolution of Sister Chromatid Cohesion	93	4.12e-19	2.41e-17	0.56100	-0.124000	0.547000	3.94e-02	7.85e-20
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	81	1.40e-16	6.35e-15	0.56000	-0.140000	0.542000	2.92e-02	3.67e-17
Amplification of signal from the kinetochores	81	1.40e-16	6.35e-15	0.56000	-0.140000	0.542000	2.92e-02	3.67e-17
Transport of Mature mRNA Derived from an Intronless Transcript	40	1.77e-08	1.99e-07	0.55800	-0.168000	0.533000	6.62e-02	5.65e-09
Interactions of Vpr with host cellular proteins	34	3.20e-07	2.81e-06	0.55800	-0.212000	0.516000	3.27e-02	1.94e-07
G0 and Early G1	24	1.11e-05	6.90e-05	0.55400	0.076000	0.549000	5.19e-01	3.22e-06
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	1.38e-02	3.55e-02	0.55400	0.265000	-0.486000	1.46e-01	7.81e-03
G2/M DNA damage checkpoint	56	1.33e-11	3.03e-10	0.54900	-0.050800	0.547000	5.11e-01	1.47e-12
Establishment of Sister Chromatid Cohesion	10	9.46e-03	2.58e-02	0.54900	0.078000	0.543000	6.69e-01	2.95e-03
Processing of Intronless Pre-mRNAs	16	7.03e-04	2.85e-03	0.54800	0.001190	0.548000	9.93e-01	1.48e-04
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	8.79e-04	3.42e-03	0.54700	-0.080100	0.541000	5.79e-01	1.80e-04
Interleukin-10 signaling	13	2.63e-03	9.01e-03	0.54600	-0.049200	-0.543000	7.59e-01	6.93e-04
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	6.29e-04	2.59e-03	0.54300	0.112000	0.531000	4.39e-01	2.36e-04
Glycosphingolipid metabolism	28	2.88e-06	1.96e-05	0.54000	-0.115000	-0.527000	2.94e-01	1.38e-06
DNA Replication	116	1.15e-22	1.01e-20	0.53900	-0.004020	0.539000	9.41e-01	1.27e-23
Formation of tubulin folding intermediates by CCT/TriC	13	4.15e-03	1.33e-02	0.53800	-0.108000	0.527000	4.98e-01	1.00e-03
HDR through MMEJ (alt-NHEJ)	11	7.39e-03	2.08e-02	0.53200	0.140000	0.513000	4.22e-01	3.24e-03
Cell Cycle Checkpoints	229	2.85e-41	8.74e-39	0.53000	-0.083400	0.524000	3.07e-02	2.62e-42
Signaling by Leptin	10	1.47e-02	3.77e-02	0.52800	-0.002180	-0.528000	9.90e-01	3.82e-03
SUMOylation of SUMOylation proteins	32	2.69e-06	1.84e-05	0.52700	-0.131000	0.510000	2.01e-01	5.87e-07
Mismatch Repair	13	4.13e-03	1.33e-02	0.52600	0.024900	0.526000	8.76e-01	1.03e-03
HDR through Single Strand Annealing (SSA)	35	4.78e-07	4.08e-06	0.52500	-0.001120	0.525000	9.91e-01	7.67e-08
G1/S Transition	117	2.17e-21	1.57e-19	0.52400	-0.041900	0.523000	4.35e-01	1.76e-22
Regulation of FOXO transcriptional activity by acetylation	10	2.18e-02	5.28e-02	0.52300	0.253000	-0.458000	1.66e-01	1.21e-02
Synthesis of DNA	109	8.72e-20	5.63e-18	0.51900	-0.015900	0.519000	7.75e-01	8.55e-21
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	8.31e-03	2.30e-02	0.51600	-0.025000	0.516000	8.81e-01	1.98e-03
tRNA processing in the nucleus	54	8.58e-10	1.35e-08	0.51500	-0.094300	0.506000	2.31e-01	1.27e-10
Initiation of Nuclear Envelope (NE) Reformation	18	7.22e-04	2.90e-03	0.51300	0.033400	0.512000	8.06e-01	1.71e-04
NS1 Mediated Effects on Host Pathways	38	6.33e-07	5.22e-06	0.51200	-0.152000	0.489000	1.05e-01	1.84e-07
DNA Replication Pre-Initiation	92	2.43e-16	1.07e-14	0.51100	-0.016400	0.511000	7.86e-01	2.55e-17
Transcription of E2F targets under negative control by DREAM complex	18	7.11e-04	2.87e-03	0.51100	0.060400	0.508000	6.58e-01	1.94e-04
Nuclear Pore Complex (NPC) Disassembly	34	3.63e-06	2.39e-05	0.51100	-0.197000	0.471000	4.64e-02	2.03e-06
Orc1 removal from chromatin	63	4.36e-11	8.78e-10	0.50800	-0.071100	0.503000	3.30e-01	5.27e-12
Processing of DNA double-strand break ends	57	2.12e-10	3.94e-09	0.50700	0.028800	0.506000	7.07e-01	4.01e-11
EML4 and NUDC in mitotic spindle formation	85	3.06e-14	9.90e-13	0.50600	-0.150000	0.484000	1.74e-02	1.33e-14
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	31	1.15e-05	7.08e-05	0.50600	0.152000	-0.483000	1.43e-01	3.28e-06
Mitotic Spindle Checkpoint	96	5.19e-16	2.12e-14	0.50500	-0.127000	0.489000	3.25e-02	1.33e-16
Major pathway of rRNA processing in the nucleolus and cytosol	156	3.20e-25	3.27e-23	0.50400	-0.137000	0.484000	3.26e-03	1.91e-25
rRNA processing in the nucleus and cytosol	164	3.45e-26	4.24e-24	0.50200	-0.154000	0.478000	6.95e-04	5.53e-26
SUMOylation of ubiquitinylation proteins	37	2.28e-06	1.60e-05	0.50000	-0.207000	0.455000	2.91e-02	1.73e-06
Resolution of Abasic Sites (AP sites)	32	4.05e-06	2.65e-05	0.49700	0.122000	0.482000	2.34e-01	2.45e-06
rRNA processing	169	1.94e-26	2.64e-24	0.49700	-0.144000	0.475000	1.35e-03	1.92e-26
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	1.17e-02	3.12e-02	0.49600	-0.006610	0.496000	9.68e-01	2.95e-03
mRNA decay by 3’ to 5’ exoribonuclease	14	6.70e-03	1.93e-02	0.49500	-0.096800	0.486000	5.31e-01	1.66e-03
Viral Messenger RNA Synthesis	41	6.46e-07	5.29e-06	0.49100	-0.122000	0.475000	1.77e-01	1.40e-07
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	4.13e-03	1.33e-02	0.48800	0.044700	0.486000	7.64e-01	1.11e-03
Termination of O-glycan biosynthesis	10	3.13e-02	7.08e-02	0.48700	0.090100	-0.479000	6.22e-01	8.80e-03
Chromosome Maintenance	81	3.37e-13	9.20e-12	0.48400	0.013600	0.484000	8.33e-01	5.21e-14
Transcriptional regulation by small RNAs	45	2.78e-07	2.49e-06	0.48400	-0.143000	0.463000	9.77e-02	8.05e-08
Growth hormone receptor signaling	17	2.36e-03	8.21e-03	0.48300	-0.024200	-0.483000	8.63e-01	5.73e-04
Cytosolic iron-sulfur cluster assembly	10	2.25e-02	5.42e-02	0.48300	0.424000	0.231000	2.01e-02	2.06e-01
Mitotic G1 phase and G1/S transition	131	1.76e-20	1.20e-18	0.48300	-0.014600	0.482000	7.74e-01	1.71e-21
Separation of Sister Chromatids	149	2.05e-22	1.68e-20	0.48200	-0.104000	0.471000	2.88e-02	3.87e-23
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	51	7.54e-08	7.65e-07	0.47900	-0.202000	0.434000	1.28e-02	8.38e-08
tRNA processing	96	8.93e-15	3.23e-13	0.47700	-0.034100	0.476000	5.64e-01	8.81e-16
Telomere C-strand (Lagging Strand) Synthesis	31	1.89e-05	1.10e-04	0.47600	0.070000	0.471000	5.00e-01	5.72e-06
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	1.72e-02	4.34e-02	0.47600	0.298000	-0.371000	6.25e-02	2.06e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	53	3.40e-08	3.70e-07	0.47500	-0.125000	0.458000	1.16e-01	8.02e-09
HDR through Homologous Recombination (HRR)	61	1.12e-09	1.71e-08	0.47500	-0.011000	0.475000	8.82e-01	1.49e-10
Homology Directed Repair	93	1.15e-14	4.04e-13	0.47400	0.056000	0.471000	3.52e-01	4.43e-15
Signal regulatory protein family interactions	10	2.50e-02	5.85e-02	0.47400	-0.291000	-0.374000	1.11e-01	4.08e-02
S Phase	146	4.91e-22	3.77e-20	0.47200	0.019500	0.472000	6.85e-01	9.09e-23
Signaling by BMP	16	7.31e-03	2.06e-02	0.47000	0.240000	-0.404000	9.71e-02	5.12e-03
RNA Polymerase I Promoter Escape	26	2.11e-04	9.76e-04	0.47000	-0.058700	0.466000	6.05e-01	3.94e-05
Translation initiation complex formation	50	1.99e-07	1.82e-06	0.46900	-0.197000	0.425000	1.59e-02	2.00e-07
Metabolism of folate and pterines	11	3.55e-02	7.78e-02	0.46800	-0.383000	0.269000	2.76e-02	1.23e-01
tRNA Aminoacylation	23	7.45e-04	2.96e-03	0.46800	-0.148000	0.444000	2.19e-01	2.27e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.33e-02	3.46e-02	0.46800	-0.324000	-0.337000	5.19e-02	4.32e-02
Transcriptional Regulation by E2F6	30	3.83e-05	2.09e-04	0.46600	0.094700	0.456000	3.70e-01	1.55e-05
Cap-dependent Translation Initiation	101	3.64e-14	1.12e-12	0.46600	-0.162000	0.437000	5.12e-03	3.70e-14
Eukaryotic Translation Initiation	101	3.64e-14	1.12e-12	0.46600	-0.162000	0.437000	5.12e-03	3.70e-14
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	87	3.97e-13	1.06e-11	0.46400	0.041800	0.462000	5.01e-01	1.03e-13
Influenza Viral RNA Transcription and Replication	117	3.62e-16	1.53e-14	0.46200	-0.142000	0.440000	8.06e-03	2.24e-16
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	2.56e-02	5.96e-02	0.46200	0.083400	0.455000	6.32e-01	9.03e-03
Mitotic Metaphase and Anaphase	198	4.09e-27	8.37e-25	0.46200	-0.091300	0.453000	2.75e-02	6.36e-28
Switching of origins to a post-replicative state	82	6.60e-12	1.56e-10	0.46200	-0.051300	0.459000	4.22e-01	7.29e-13
SARS-CoV-2 modulates host translation machinery	41	3.53e-06	2.33e-05	0.46100	-0.122000	0.445000	1.78e-01	8.34e-07
Assembly of the pre-replicative complex	77	4.16e-11	8.66e-10	0.46000	-0.066400	0.455000	3.15e-01	5.08e-12
Formation of the ternary complex, and subsequently, the 43S complex	43	2.55e-06	1.77e-05	0.46000	-0.165000	0.429000	6.19e-02	1.13e-06
Mitotic Anaphase	197	1.23e-26	1.88e-24	0.45900	-0.089000	0.450000	3.21e-02	1.80e-27
Base Excision Repair	39	2.96e-06	1.99e-05	0.45900	0.077500	0.452000	4.02e-01	1.06e-06
ROS and RNS production in phagocytes	23	5.19e-04	2.19e-03	0.45800	-0.097700	-0.448000	4.17e-01	2.03e-04
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	67	1.73e-09	2.56e-08	0.45800	-0.125000	0.441000	7.64e-02	4.56e-10
L13a-mediated translational silencing of Ceruloplasmin expression	93	1.13e-12	2.96e-11	0.45800	-0.163000	0.428000	6.62e-03	1.11e-12
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	3.72e-02	8.10e-02	0.45600	0.124000	-0.439000	4.75e-01	1.18e-02
alpha-linolenic acid (ALA) metabolism	11	3.72e-02	8.10e-02	0.45600	0.124000	-0.439000	4.75e-01	1.18e-02
Hyaluronan metabolism	11	4.15e-02	8.91e-02	0.45500	0.222000	-0.397000	2.02e-01	2.25e-02
SUMOylation of RNA binding proteins	42	4.17e-06	2.71e-05	0.45100	-0.097800	0.440000	2.73e-01	8.05e-07
SRP-dependent cotranslational protein targeting to membrane	93	2.46e-12	6.04e-11	0.45000	-0.143000	0.426000	1.71e-02	1.28e-12
GTP hydrolysis and joining of the 60S ribosomal subunit	94	2.35e-12	5.89e-11	0.44900	-0.161000	0.419000	7.23e-03	2.24e-12
Ribosomal scanning and start codon recognition	50	7.71e-07	6.11e-06	0.44800	-0.194000	0.404000	1.78e-02	7.85e-07
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	45	1.93e-06	1.39e-05	0.44800	-0.086700	0.440000	3.15e-01	3.39e-07
p53-Independent DNA Damage Response	45	1.93e-06	1.39e-05	0.44800	-0.086700	0.440000	3.15e-01	3.39e-07
p53-Independent G1/S DNA damage checkpoint	45	1.93e-06	1.39e-05	0.44800	-0.086700	0.440000	3.15e-01	3.39e-07
APC/C:Cdc20 mediated degradation of mitotic proteins	66	5.62e-09	7.19e-08	0.44700	-0.115000	0.432000	1.08e-01	1.28e-09
Formation of a pool of free 40S subunits	83	6.73e-11	1.31e-09	0.44700	-0.159000	0.418000	1.26e-02	5.05e-11
Selenocysteine synthesis	74	1.03e-09	1.60e-08	0.44600	-0.170000	0.412000	1.14e-02	9.61e-10
RHO GTPases Activate NADPH Oxidases	14	1.61e-02	4.09e-02	0.44400	0.025400	-0.443000	8.69e-01	4.08e-03
Elevation of cytosolic Ca2+ levels	10	5.29e-02	1.07e-01	0.44200	0.014400	-0.442000	9.37e-01	1.55e-02
Influenza Infection	135	4.22e-17	2.07e-15	0.44200	-0.117000	0.426000	1.90e-02	1.39e-17
APC/C-mediated degradation of cell cycle proteins	78	2.56e-10	4.55e-09	0.44100	-0.082400	0.434000	2.09e-01	3.78e-11
Regulation of mitotic cell cycle	78	2.56e-10	4.55e-09	0.44100	-0.082400	0.434000	2.09e-01	3.78e-11
Glycolysis	58	1.16e-07	1.14e-06	0.43900	-0.135000	0.418000	7.63e-02	3.73e-08
Gene Silencing by RNA	62	4.48e-08	4.78e-07	0.43900	-0.156000	0.410000	3.40e-02	2.35e-08
Selenoamino acid metabolism	82	2.16e-10	3.96e-09	0.43800	-0.159000	0.409000	1.28e-02	1.70e-10
Translation	241	5.51e-29	1.35e-26	0.43800	-0.132000	0.418000	4.64e-04	9.72e-29
Viral mRNA Translation	73	2.79e-09	3.73e-08	0.43700	-0.157000	0.408000	2.08e-02	1.77e-09
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	79	6.00e-10	9.87e-09	0.43700	-0.166000	0.404000	1.10e-02	5.55e-10
Extension of Telomeres	47	1.26e-06	9.75e-06	0.43500	0.034300	0.434000	6.85e-01	2.76e-07
Processive synthesis on the C-strand of the telomere	17	6.25e-03	1.83e-02	0.43500	0.117000	0.419000	4.02e-01	2.82e-03
Diseases of programmed cell death	39	9.23e-06	5.79e-05	0.43500	0.111000	0.420000	2.32e-01	5.68e-06
Transport of Mature Transcript to Cytoplasm	66	1.41e-08	1.63e-07	0.43300	-0.066000	0.428000	3.54e-01	1.96e-09
Translesion Synthesis by POLH	18	6.26e-03	1.83e-02	0.43200	0.003540	0.432000	9.79e-01	1.52e-03
Insulin receptor recycling	18	6.83e-03	1.96e-02	0.43200	0.037700	-0.430000	7.82e-01	1.59e-03
Interleukin-6 signaling	10	4.93e-02	1.01e-01	0.43200	-0.184000	-0.390000	3.13e-01	3.26e-02
Mitochondrial translation	84	1.74e-10	3.28e-09	0.43100	-0.097100	0.419000	1.25e-01	3.20e-11
Caspase-mediated cleavage of cytoskeletal proteins	10	7.81e-02	1.48e-01	0.42900	0.354000	-0.243000	5.27e-02	1.84e-01
Eukaryotic Translation Elongation	76	2.58e-09	3.48e-08	0.42800	-0.144000	0.403000	3.00e-02	1.26e-09
Regulation of APC/C activators between G1/S and early anaphase	71	6.64e-09	8.32e-08	0.42800	-0.095100	0.418000	1.66e-01	1.21e-09
Cross-presentation of soluble exogenous antigens (endosomes)	39	3.16e-05	1.78e-04	0.42800	-0.092900	0.418000	3.16e-01	6.42e-06
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	64	4.92e-08	5.21e-07	0.42700	-0.101000	0.415000	1.61e-01	9.92e-09
Response of EIF2AK4 (GCN2) to amino acid deficiency	82	7.18e-10	1.16e-08	0.42700	-0.156000	0.397000	1.45e-02	5.48e-10
Mitochondrial translation elongation	79	7.97e-10	1.27e-08	0.42600	-0.071800	0.420000	2.71e-01	1.11e-10
Cristae formation	11	6.27e-02	1.24e-01	0.42600	-0.235000	0.355000	1.77e-01	4.13e-02
PKA-mediated phosphorylation of CREB	12	3.25e-02	7.22e-02	0.42500	-0.114000	-0.410000	4.95e-01	1.40e-02
Peptide chain elongation	73	8.37e-09	1.01e-07	0.42400	-0.149000	0.397000	2.81e-02	4.56e-09
tRNA modification in the nucleus and cytosol	37	3.47e-05	1.95e-04	0.42200	0.078000	0.415000	4.12e-01	1.27e-05
RNA Polymerase I Transcription Initiation	40	1.86e-05	1.09e-04	0.42200	0.033900	0.421000	7.11e-01	4.20e-06
Mitochondrial tRNA aminoacylation	18	1.04e-02	2.81e-02	0.42200	-0.136000	0.399000	3.17e-01	3.40e-03
RNA Polymerase I Transcription Termination	24	1.87e-03	6.66e-03	0.42100	-0.051000	0.418000	6.66e-01	3.95e-04
RNA Polymerase II Transcription Termination	48	1.86e-06	1.37e-05	0.42100	0.073700	0.414000	3.78e-01	7.01e-07
Mitochondrial translation termination	78	2.07e-09	2.95e-08	0.42000	-0.080900	0.412000	2.17e-01	3.22e-10
DNA Double-Strand Break Repair	119	1.50e-14	5.10e-13	0.42000	0.028800	0.419000	5.88e-01	3.27e-15
KSRP (KHSRP) binds and destabilizes mRNA	15	1.88e-02	4.72e-02	0.41900	-0.007000	0.419000	9.63e-01	4.93e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	47	4.95e-06	3.18e-05	0.41900	-0.042700	0.417000	6.13e-01	7.71e-07
Regulation of IFNG signaling	13	2.36e-02	5.58e-02	0.41900	-0.312000	-0.279000	5.17e-02	8.12e-02
Mitochondrial translation initiation	79	2.28e-09	3.11e-08	0.41800	-0.095200	0.407000	1.44e-01	4.29e-10
SUMOylation of transcription factors	13	2.43e-02	5.70e-02	0.41700	0.273000	0.315000	8.81e-02	4.93e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	63	1.37e-07	1.32e-06	0.41700	-0.096900	0.405000	1.84e-01	2.70e-08
Synthesis of PIPs at the Golgi membrane	12	3.26e-02	7.22e-02	0.41600	-0.295000	-0.294000	7.65e-02	7.83e-02
Nuclear Envelope (NE) Reassembly	60	3.02e-07	2.67e-06	0.41600	-0.090700	0.406000	2.25e-01	5.63e-08
Effects of PIP2 hydrolysis	19	6.93e-03	1.98e-02	0.41500	-0.011400	-0.415000	9.31e-01	1.74e-03
Cell Cycle, Mitotic	433	3.79e-47	1.55e-44	0.41400	-0.037000	0.413000	1.92e-01	2.05e-48
Recognition of DNA damage by PCNA-containing replication complex	28	4.27e-04	1.85e-03	0.41400	0.184000	0.371000	9.26e-02	6.81e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript	57	6.53e-07	5.31e-06	0.41300	-0.063300	0.408000	4.09e-01	1.01e-07
Interleukin-6 family signaling	13	2.74e-02	6.37e-02	0.41200	-0.215000	-0.351000	1.79e-01	2.84e-02
Myogenesis	13	4.90e-02	1.01e-01	0.41100	0.303000	-0.277000	5.85e-02	8.38e-02
HCMV Early Events	51	4.39e-06	2.83e-05	0.41000	-0.106000	0.396000	1.92e-01	1.01e-06
Telomere Maintenance	61	1.68e-07	1.57e-06	0.41000	0.025800	0.409000	7.28e-01	3.36e-08
Phosphorylation of CD3 and TCR zeta chains	10	6.61e-02	1.30e-01	0.41000	-0.184000	-0.366000	3.14e-01	4.51e-02
Fanconi Anemia Pathway	29	8.89e-04	3.43e-03	0.40900	-0.098200	0.397000	3.60e-01	2.14e-04
RNA Polymerase I Promoter Clearance	44	1.58e-05	9.34e-05	0.40900	-0.007680	0.409000	9.30e-01	2.73e-06
RNA Polymerase I Transcription	44	1.58e-05	9.34e-05	0.40900	-0.007680	0.409000	9.30e-01	2.73e-06
ERK/MAPK targets	18	1.34e-02	3.48e-02	0.40900	0.124000	-0.390000	3.62e-01	4.22e-03
G1/S DNA Damage Checkpoints	59	4.56e-07	3.91e-06	0.40900	-0.037700	0.407000	6.17e-01	6.51e-08
SCF(Skp2)-mediated degradation of p27/p21	53	2.00e-06	1.43e-05	0.40900	-0.035100	0.407000	6.58e-01	3.00e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	43	2.93e-05	1.66e-04	0.40800	-0.075900	0.401000	3.89e-01	5.46e-06
Nuclear signaling by ERBB4	16	2.34e-02	5.57e-02	0.40700	0.153000	-0.377000	2.89e-01	9.01e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	24	1.62e-03	5.88e-03	0.40700	0.187000	0.361000	1.13e-01	2.21e-03
G alpha (s) signalling events	47	1.80e-05	1.06e-04	0.40600	0.161000	-0.373000	5.57e-02	9.95e-06
Translesion synthesis by REV1	15	2.78e-02	6.43e-02	0.40600	-0.096200	0.395000	5.19e-01	8.17e-03
Mitotic Prometaphase	162	3.12e-17	1.59e-15	0.40600	-0.106000	0.392000	2.03e-02	9.77e-18
SCF-beta-TrCP mediated degradation of Emi1	48	9.37e-06	5.84e-05	0.40600	-0.060400	0.401000	4.70e-01	1.56e-06
Metabolism of RNA	564	1.34e-57	1.64e-54	0.40500	-0.045100	0.403000	7.15e-02	6.99e-59
Cell Cycle	541	1.28e-55	7.86e-53	0.40500	-0.033100	0.403000	1.95e-01	6.41e-57
CLEC7A (Dectin-1) induces NFAT activation	11	6.17e-02	1.23e-01	0.40200	-0.083300	-0.393000	6.32e-01	2.39e-02
Sialic acid metabolism	23	4.75e-03	1.49e-02	0.40200	0.105000	-0.388000	3.83e-01	1.29e-03
Autodegradation of the E3 ubiquitin ligase COP1	45	2.54e-05	1.46e-04	0.40100	-0.071400	0.395000	4.08e-01	4.62e-06
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	65	2.32e-07	2.11e-06	0.40100	-0.068600	0.396000	3.40e-01	3.62e-08
Regulation of ornithine decarboxylase (ODC)	44	2.91e-05	1.65e-04	0.40100	-0.044300	0.398000	6.11e-01	4.88e-06
Other semaphorin interactions	10	1.11e-01	1.97e-01	0.39800	0.228000	-0.327000	2.13e-01	7.34e-02
Synthesis of PC	22	7.09e-03	2.01e-02	0.39800	0.144000	-0.371000	2.41e-01	2.59e-03
G alpha (z) signalling events	24	3.94e-03	1.28e-02	0.39700	0.066700	-0.391000	5.71e-01	9.12e-04
Membrane binding and targetting of GAG proteins	12	7.43e-02	1.43e-01	0.39700	0.294000	-0.266000	7.79e-02	1.10e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	7.43e-02	1.43e-01	0.39700	0.294000	-0.266000	7.79e-02	1.10e-01
Prefoldin mediated transfer of substrate to CCT/TriC	18	1.31e-02	3.43e-02	0.39700	0.030500	0.395000	8.23e-01	3.69e-03
Signaling by high-kinase activity BRAF mutants	23	5.71e-03	1.70e-02	0.39600	0.113000	-0.379000	3.47e-01	1.66e-03
Mitochondrial protein import	49	1.42e-05	8.51e-05	0.39500	-0.072100	0.389000	3.83e-01	2.56e-06
Synthesis of IP3 and IP4 in the cytosol	16	2.94e-02	6.70e-02	0.39500	0.150000	-0.365000	3.01e-01	1.15e-02
mRNA Capping	25	2.44e-03	8.45e-03	0.39400	0.056400	0.390000	6.26e-01	7.34e-04
Eukaryotic Translation Termination	77	5.65e-08	5.88e-07	0.39300	-0.162000	0.358000	1.43e-02	5.65e-08
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	47	2.09e-05	1.21e-04	0.39300	-0.032700	0.392000	6.99e-01	3.45e-06
MAPK targets/ Nuclear events mediated by MAP kinases	25	4.08e-03	1.32e-02	0.39200	0.113000	-0.375000	3.26e-01	1.18e-03
Early Phase of HIV Life Cycle	13	5.28e-02	1.07e-01	0.39100	-0.048700	0.388000	7.61e-01	1.53e-02
ABC transporters in lipid homeostasis	11	6.53e-02	1.29e-01	0.39100	-0.177000	-0.349000	3.10e-01	4.50e-02
CDK-mediated phosphorylation and removal of Cdc6	63	7.07e-07	5.71e-06	0.39100	-0.046400	0.388000	5.25e-01	1.04e-07
Metabolism of polyamines	50	1.27e-05	7.72e-05	0.39100	-0.040500	0.388000	6.21e-01	2.05e-06
RHO GTPases Activate ROCKs	13	6.44e-02	1.27e-01	0.39000	0.320000	-0.224000	4.59e-02	1.62e-01
Stabilization of p53	50	1.30e-05	7.85e-05	0.39000	-0.037900	0.388000	6.44e-01	2.10e-06
Polymerase switching on the C-strand of the telomere	24	3.37e-03	1.13e-02	0.39000	0.078100	0.382000	5.08e-01	1.21e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	24	3.48e-03	1.16e-02	0.38900	-0.067600	-0.384000	5.67e-01	1.15e-03
Meiosis	43	5.20e-05	2.78e-04	0.38900	0.010900	0.389000	9.01e-01	1.03e-05
Vif-mediated degradation of APOBEC3G	44	5.96e-05	3.13e-04	0.38800	-0.058500	0.384000	5.02e-01	1.07e-05
Regulation of TP53 Activity through Phosphorylation	81	1.37e-08	1.60e-07	0.38800	-0.025500	0.387000	6.92e-01	1.78e-09
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	94	1.97e-09	2.85e-08	0.38800	-0.129000	0.366000	3.07e-02	9.38e-10
Nonsense-Mediated Decay (NMD)	94	1.97e-09	2.85e-08	0.38800	-0.129000	0.366000	3.07e-02	9.38e-10
Glutamate Neurotransmitter Release Cycle	12	7.73e-02	1.47e-01	0.38700	0.362000	-0.138000	2.99e-02	4.07e-01
Ubiquitin-dependent degradation of Cyclin D	45	5.25e-05	2.79e-04	0.38700	-0.067900	0.381000	4.31e-01	9.77e-06
p53-Dependent G1 DNA Damage Response	57	2.92e-06	1.97e-05	0.38700	-0.016500	0.387000	8.30e-01	4.58e-07
p53-Dependent G1/S DNA damage checkpoint	57	2.92e-06	1.97e-05	0.38700	-0.016500	0.387000	8.30e-01	4.58e-07
Epigenetic regulation of gene expression	77	1.66e-08	1.89e-07	0.38600	0.089200	0.375000	1.77e-01	1.30e-08
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	1.29e-01	2.16e-01	0.38600	0.258000	-0.287000	1.58e-01	1.17e-01
FGFR2 alternative splicing	22	6.69e-03	1.93e-02	0.38400	0.045400	0.382000	7.12e-01	1.95e-03
Processing of Capped Intron-Containing Pre-mRNA	200	1.93e-19	1.18e-17	0.38400	-0.038800	0.382000	3.47e-01	1.65e-20
Regulation of HSF1-mediated heat shock response	67	5.36e-07	4.48e-06	0.38400	-0.059100	0.379000	4.03e-01	8.23e-08
Regulation of expression of SLITs and ROBOs	131	1.19e-12	3.05e-11	0.38400	-0.106000	0.369000	3.76e-02	3.62e-13
HIV Transcription Initiation	40	1.35e-04	6.54e-04	0.38300	0.012600	0.383000	8.91e-01	2.78e-05
RNA Polymerase II HIV Promoter Escape	40	1.35e-04	6.54e-04	0.38300	0.012600	0.383000	8.91e-01	2.78e-05
RNA Polymerase II Promoter Escape	40	1.35e-04	6.54e-04	0.38300	0.012600	0.383000	8.91e-01	2.78e-05
RNA Polymerase II Transcription Initiation	40	1.35e-04	6.54e-04	0.38300	0.012600	0.383000	8.91e-01	2.78e-05
RNA Polymerase II Transcription Initiation And Promoter Clearance	40	1.35e-04	6.54e-04	0.38300	0.012600	0.383000	8.91e-01	2.78e-05
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	40	1.35e-04	6.54e-04	0.38300	0.012600	0.383000	8.91e-01	2.78e-05
Spry regulation of FGF signaling	15	4.67e-02	9.71e-02	0.38300	0.197000	-0.328000	1.86e-01	2.77e-02
Cytochrome P450 - arranged by substrate type	14	5.33e-02	1.07e-01	0.38300	0.122000	-0.363000	4.28e-01	1.88e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	19	1.49e-02	3.81e-02	0.38200	0.009100	0.382000	9.45e-01	3.95e-03
NoRC negatively regulates rRNA expression	41	9.44e-05	4.79e-04	0.38200	0.059800	0.377000	5.08e-01	2.94e-05
Other interleukin signaling	15	4.43e-02	9.33e-02	0.38200	0.125000	-0.361000	4.01e-01	1.57e-02
WNT5A-dependent internalization of FZD4	10	1.14e-01	2.00e-01	0.38200	0.380000	-0.031400	3.73e-02	8.64e-01
mRNA Splicing - Major Pathway	150	8.56e-15	3.19e-13	0.38100	-0.012600	0.381000	7.91e-01	9.27e-16
FOXO-mediated transcription of cell cycle genes	14	5.79e-02	1.16e-01	0.38000	0.159000	-0.346000	3.04e-01	2.52e-02
Activated NOTCH1 Transmits Signal to the Nucleus	19	2.17e-02	5.27e-02	0.38000	0.177000	-0.336000	1.81e-01	1.13e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	3.14e-02	7.09e-02	0.37900	0.141000	0.352000	3.44e-01	1.83e-02
Regulation of Apoptosis	46	6.04e-05	3.15e-04	0.37800	-0.041900	0.376000	6.23e-01	1.05e-05
Regulation of FZD by ubiquitination	12	9.47e-02	1.73e-01	0.37800	0.266000	-0.268000	1.10e-01	1.08e-01
RNA Pol II CTD phosphorylation and interaction with CE	23	5.64e-03	1.68e-02	0.37800	0.101000	0.364000	4.02e-01	2.53e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	23	5.64e-03	1.68e-02	0.37800	0.101000	0.364000	4.02e-01	2.53e-03
Interleukin-37 signaling	17	2.30e-02	5.51e-02	0.37700	-0.068700	-0.371000	6.24e-01	8.11e-03
Positive epigenetic regulation of rRNA expression	41	1.59e-04	7.50e-04	0.37700	-0.011100	0.377000	9.02e-01	2.98e-05
APC/C:Cdc20 mediated degradation of Securin	59	5.06e-06	3.24e-05	0.37700	-0.072800	0.370000	3.34e-01	9.11e-07
mRNA 3’-end processing	40	1.55e-04	7.39e-04	0.37700	0.054000	0.373000	5.55e-01	4.56e-05
Interferon gamma signaling	53	1.44e-05	8.60e-05	0.37600	0.023100	-0.375000	7.72e-01	2.36e-06
Uptake and function of anthrax toxins	10	1.23e-01	2.11e-01	0.37500	0.028400	-0.374000	8.76e-01	4.06e-02
RHO GTPases Activate Formins	101	1.33e-09	2.01e-08	0.37500	-0.086900	0.365000	1.32e-01	2.56e-10
M Phase	303	5.50e-27	9.64e-25	0.37400	-0.071600	0.367000	3.36e-02	7.78e-28
Transferrin endocytosis and recycling	20	1.36e-02	3.52e-02	0.37400	-0.036900	-0.372000	7.75e-01	3.98e-03
Dual Incision in GG-NER	36	3.02e-04	1.33e-03	0.37300	0.170000	0.332000	7.69e-02	5.74e-04
Glucagon signaling in metabolic regulation	17	2.42e-02	5.68e-02	0.37300	-0.090500	-0.362000	5.18e-01	9.81e-03
Inactivation of APC/C via direct inhibition of the APC/C complex	19	2.31e-02	5.51e-02	0.37300	-0.123000	0.352000	3.55e-01	7.88e-03
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	2.31e-02	5.51e-02	0.37300	-0.123000	0.352000	3.55e-01	7.88e-03
Nuclear Envelope Breakdown	50	4.68e-05	2.53e-04	0.37200	-0.097100	0.360000	2.35e-01	1.11e-05
Vpu mediated degradation of CD4	45	1.14e-04	5.76e-04	0.37100	-0.053500	0.367000	5.35e-01	2.09e-05
Downregulation of ERBB2:ERBB3 signaling	10	1.47e-01	2.40e-01	0.37100	0.179000	-0.325000	3.28e-01	7.53e-02
Degradation of DVL	49	5.15e-05	2.76e-04	0.37000	-0.043000	0.367000	6.03e-01	8.91e-06
Diseases of carbohydrate metabolism	23	7.51e-03	2.11e-02	0.36900	-0.072300	-0.362000	5.49e-01	2.66e-03
Gap-filling DNA repair synthesis and ligation in TC-NER	55	6.59e-06	4.17e-05	0.36900	0.133000	0.344000	8.83e-02	1.05e-05
Transcription of the HIV genome	58	8.53e-06	5.37e-05	0.36800	-0.030000	0.367000	6.93e-01	1.36e-06
Signaling by RAF1 mutants	26	5.83e-03	1.73e-02	0.36800	0.065900	-0.362000	5.61e-01	1.40e-03
mRNA Splicing - Minor Pathway	45	1.40e-04	6.76e-04	0.36700	-0.058500	0.362000	4.98e-01	2.64e-05
MAP2K and MAPK activation	26	6.61e-03	1.92e-02	0.36700	0.104000	-0.352000	3.60e-01	1.92e-03
Removal of the Flap Intermediate from the C-strand	15	4.24e-02	9.01e-02	0.36700	0.079000	0.358000	5.96e-01	1.64e-02
DAG and IP3 signaling	27	4.38e-03	1.40e-02	0.36600	0.012200	-0.366000	9.13e-01	9.99e-04
SUMOylation of DNA damage response and repair proteins	70	1.07e-06	8.41e-06	0.36600	-0.045600	0.363000	5.10e-01	1.60e-07
Diseases associated with the TLR signaling cascade	19	2.09e-02	5.11e-02	0.36400	-0.037600	-0.362000	7.77e-01	6.32e-03
Diseases of Immune System	19	2.09e-02	5.11e-02	0.36400	-0.037600	-0.362000	7.77e-01	6.32e-03
Translesion synthesis by POLI	16	5.03e-02	1.03e-01	0.36400	-0.141000	0.335000	3.29e-01	2.04e-02
Cyclin E associated events during G1/S transition	73	4.85e-07	4.10e-06	0.36400	0.005720	0.364000	9.33e-01	8.19e-08
Signaling by FGFR2 IIIa TM	15	5.41e-02	1.09e-01	0.36300	-0.040700	0.360000	7.85e-01	1.57e-02
Plasma lipoprotein remodeling	12	9.77e-02	1.77e-01	0.36200	0.359000	-0.047300	3.12e-02	7.77e-01
mRNA Splicing	158	4.39e-14	1.30e-12	0.36200	-0.011300	0.362000	8.08e-01	4.88e-15
Cyclin A:Cdk2-associated events at S phase entry	75	3.64e-07	3.15e-06	0.36100	0.021100	0.360000	7.52e-01	7.20e-08
Interleukin-15 signaling	13	8.83e-02	1.64e-01	0.36100	0.105000	-0.345000	5.14e-01	3.12e-02
RHOBTB1 GTPase cycle	19	2.04e-02	5.05e-02	0.35900	0.341000	0.112000	1.01e-02	4.00e-01
Arachidonic acid metabolism	21	1.93e-02	4.80e-02	0.35800	0.060800	-0.353000	6.29e-01	5.10e-03
Hh mutants are degraded by ERAD	48	1.20e-04	6.06e-04	0.35800	-0.055300	0.354000	5.08e-01	2.24e-05
Phosphorylation of the APC/C	18	3.86e-02	8.33e-02	0.35800	-0.142000	0.329000	2.97e-01	1.59e-02
Sphingolipid metabolism	51	7.17e-05	3.73e-04	0.35700	0.053900	-0.353000	5.06e-01	1.30e-05
Downregulation of ERBB2 signaling	17	4.87e-02	1.01e-01	0.35700	0.173000	-0.312000	2.16e-01	2.60e-02
Negative epigenetic regulation of rRNA expression	44	1.53e-04	7.30e-04	0.35600	0.092000	0.344000	2.91e-01	7.95e-05
Signaling by FLT3 ITD and TKD mutants	13	9.94e-02	1.79e-01	0.35600	0.315000	-0.167000	4.94e-02	2.98e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	47	1.26e-04	6.27e-04	0.35600	0.007500	0.356000	9.29e-01	2.52e-05
Glucose metabolism	72	2.26e-06	1.59e-05	0.35500	-0.098700	0.341000	1.48e-01	5.76e-07
Hh mutants abrogate ligand secretion	50	9.38e-05	4.79e-04	0.35500	-0.045200	0.352000	5.81e-01	1.68e-05
VEGFR2 mediated cell proliferation	16	5.50e-02	1.11e-01	0.35500	0.093600	-0.342000	5.17e-01	1.79e-02
Peroxisomal lipid metabolism	23	1.48e-02	3.78e-02	0.35300	0.049900	-0.349000	6.79e-01	3.73e-03
Host Interactions of HIV factors	109	3.52e-09	4.60e-08	0.35200	-0.071400	0.344000	1.99e-01	5.80e-10
EGFR downregulation	21	2.82e-02	6.47e-02	0.35100	0.223000	-0.271000	7.67e-02	3.14e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	35	1.66e-03	5.97e-03	0.35100	-0.032300	0.350000	7.41e-01	3.47e-04
HIV Transcription Elongation	35	1.66e-03	5.97e-03	0.35100	-0.032300	0.350000	7.41e-01	3.47e-04
Tat-mediated elongation of the HIV-1 transcript	35	1.66e-03	5.97e-03	0.35100	-0.032300	0.350000	7.41e-01	3.47e-04
PLC beta mediated events	30	3.60e-03	1.19e-02	0.35100	-0.022400	-0.350000	8.32e-01	9.14e-04
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	21	1.62e-02	4.09e-02	0.34900	-0.141000	-0.320000	2.65e-01	1.12e-02
Regulation of IFNA/IFNB signaling	12	8.98e-02	1.66e-01	0.34900	-0.245000	-0.249000	1.42e-01	1.35e-01
SUMOylation of chromatin organization proteins	49	1.78e-04	8.34e-04	0.34900	-0.074000	0.341000	3.71e-01	3.76e-05
Paradoxical activation of RAF signaling by kinase inactive BRAF	30	5.45e-03	1.64e-02	0.34900	0.106000	-0.332000	3.15e-01	1.66e-03
Signaling by RAS mutants	30	5.45e-03	1.64e-02	0.34900	0.106000	-0.332000	3.15e-01	1.66e-03
Signaling by moderate kinase activity BRAF mutants	30	5.45e-03	1.64e-02	0.34900	0.106000	-0.332000	3.15e-01	1.66e-03
Signaling downstream of RAS mutants	30	5.45e-03	1.64e-02	0.34900	0.106000	-0.332000	3.15e-01	1.66e-03
FCERI mediated Ca+2 mobilization	26	7.01e-03	1.99e-02	0.34800	-0.091200	-0.336000	4.21e-01	3.06e-03
GPVI-mediated activation cascade	24	1.36e-02	3.52e-02	0.34800	0.034500	-0.346000	7.70e-01	3.38e-03
Adrenaline,noradrenaline inhibits insulin secretion	14	6.58e-02	1.29e-01	0.34700	-0.150000	-0.313000	3.33e-01	4.27e-02
MicroRNA (miRNA) biogenesis	21	2.82e-02	6.47e-02	0.34400	-0.101000	0.329000	4.24e-01	9.04e-03
FCGR3A-mediated IL10 synthesis	23	1.89e-02	4.72e-02	0.34300	0.053300	-0.339000	6.58e-01	4.93e-03
Negative regulation of NOTCH4 signaling	49	2.31e-04	1.06e-03	0.34200	-0.053100	0.338000	5.21e-01	4.44e-05
Nuclear Events (kinase and transcription factor activation)	44	7.55e-04	2.99e-03	0.34100	0.136000	-0.312000	1.19e-01	3.41e-04
Hedgehog ligand biogenesis	53	1.22e-04	6.10e-04	0.34000	-0.044700	0.337000	5.74e-01	2.22e-05
Platelet calcium homeostasis	17	6.41e-02	1.27e-01	0.34000	0.161000	-0.300000	2.52e-01	3.24e-02
Formation of the Early Elongation Complex	29	6.98e-03	1.99e-02	0.33900	-0.026300	0.338000	8.07e-01	1.63e-03
Formation of the HIV-1 Early Elongation Complex	29	6.98e-03	1.99e-02	0.33900	-0.026300	0.338000	8.07e-01	1.63e-03
Vasopressin regulates renal water homeostasis via Aquaporins	22	2.06e-02	5.06e-02	0.33900	-0.035000	-0.337000	7.77e-01	6.21e-03
G beta:gamma signalling through PI3Kgamma	16	5.23e-02	1.06e-01	0.33900	-0.129000	-0.313000	3.71e-01	3.01e-02
TP53 Regulates Transcription of DNA Repair Genes	51	1.62e-04	7.61e-04	0.33900	-0.018300	0.338000	8.21e-01	2.97e-05
Response of EIF2AK1 (HRI) to heme deficiency	15	9.17e-02	1.68e-01	0.33900	-0.177000	0.288000	2.34e-01	5.33e-02
PERK regulates gene expression	27	1.26e-02	3.31e-02	0.33800	-0.123000	0.315000	2.67e-01	4.67e-03
Formation of HIV elongation complex in the absence of HIV Tat	36	2.32e-03	8.13e-03	0.33700	-0.032800	0.336000	7.34e-01	4.95e-04
Autodegradation of Cdh1 by Cdh1:APC/C	57	8.15e-05	4.21e-04	0.33600	-0.051700	0.332000	5.00e-01	1.49e-05
Defective CFTR causes cystic fibrosis	53	1.56e-04	7.40e-04	0.33500	-0.041500	0.333000	6.01e-01	2.86e-05
Dopamine Neurotransmitter Release Cycle	12	1.22e-01	2.09e-01	0.33500	0.328000	0.066900	4.90e-02	6.88e-01
CaM pathway	21	2.91e-02	6.64e-02	0.33500	0.006990	-0.335000	9.56e-01	7.96e-03
Calmodulin induced events	21	2.91e-02	6.64e-02	0.33500	0.006990	-0.335000	9.56e-01	7.96e-03
Mitotic G2-G2/M phases	161	3.89e-12	9.37e-11	0.33400	-0.038700	0.332000	3.99e-01	4.29e-13
Integrin signaling	17	7.05e-02	1.37e-01	0.33400	0.152000	-0.297000	2.79e-01	3.39e-02
Platelet Aggregation (Plug Formation)	17	7.05e-02	1.37e-01	0.33400	0.152000	-0.297000	2.79e-01	3.39e-02
Degradation of GLI2 by the proteasome	51	2.08e-04	9.62e-04	0.33300	-0.010600	0.333000	8.96e-01	3.93e-05
GLI3 is processed to GLI3R by the proteasome	51	2.08e-04	9.62e-04	0.33300	-0.010600	0.333000	8.96e-01	3.93e-05
Semaphorin interactions	39	2.63e-03	9.01e-03	0.33300	0.214000	-0.255000	2.06e-02	5.94e-03
Carboxyterminal post-translational modifications of tubulin	22	2.17e-02	5.27e-02	0.33300	-0.081900	-0.322000	5.06e-01	8.87e-03
RAF-independent MAPK1/3 activation	21	3.20e-02	7.18e-02	0.33200	0.031700	-0.331000	8.02e-01	8.69e-03
Neurotransmitter release cycle	20	4.49e-02	9.42e-02	0.33200	0.304000	-0.133000	1.87e-02	3.03e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	78	2.62e-06	1.80e-05	0.33100	-0.001550	0.331000	9.81e-01	4.37e-07
DNA Repair	248	3.29e-18	1.75e-16	0.33100	0.007500	0.330000	8.40e-01	4.80e-19
APC-Cdc20 mediated degradation of Nek2A	24	2.31e-02	5.51e-02	0.33000	-0.086200	0.319000	4.65e-01	6.92e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	29	8.36e-03	2.31e-02	0.33000	0.012500	0.329000	9.08e-01	2.15e-03
Negative regulation of FLT3	13	1.35e-01	2.25e-01	0.33000	0.120000	-0.307000	4.55e-01	5.53e-02
Cellular response to heat stress	81	2.53e-06	1.77e-05	0.32900	-0.035800	0.327000	5.78e-01	3.86e-07
Reproduction	49	3.00e-04	1.33e-03	0.32900	0.034400	0.327000	6.77e-01	7.72e-05
G2/M Transition	159	1.41e-11	3.15e-10	0.32800	-0.035200	0.326000	4.46e-01	1.58e-12
Signaling by BRAF and RAF1 fusions	43	8.47e-04	3.30e-03	0.32700	-0.036300	-0.325000	6.81e-01	2.27e-04
SUMOylation of immune response proteins	11	1.63e-01	2.61e-01	0.32700	0.325000	0.035900	6.19e-02	8.37e-01
Dual incision in TC-NER	56	7.38e-05	3.83e-04	0.32600	0.117000	0.305000	1.31e-01	8.14e-05
FGFR2 mutant receptor activation	17	7.06e-02	1.37e-01	0.32600	-0.051800	0.322000	7.12e-01	2.16e-02
GAB1 signalosome	10	2.31e-01	3.39e-01	0.32600	0.199000	-0.258000	2.76e-01	1.58e-01
RHOB GTPase cycle	44	1.11e-03	4.15e-03	0.32500	0.047400	-0.321000	5.86e-01	2.30e-04
Ca-dependent events	22	3.16e-02	7.12e-02	0.32500	0.022600	-0.324000	8.54e-01	8.58e-03
Deadenylation-dependent mRNA decay	52	2.40e-04	1.10e-03	0.32500	0.020700	0.324000	7.96e-01	5.44e-05
Nonhomologous End-Joining (NHEJ)	30	9.40e-03	2.57e-02	0.32400	-0.027700	0.323000	7.93e-01	2.25e-03
Regulation of KIT signaling	11	2.06e-01	3.13e-01	0.32300	0.243000	-0.212000	1.62e-01	2.23e-01
Listeria monocytogenes entry into host cells	15	1.14e-01	2.00e-01	0.32300	0.161000	-0.280000	2.80e-01	6.09e-02
Translesion synthesis by POLK	16	8.69e-02	1.62e-01	0.32300	-0.050300	0.319000	7.27e-01	2.74e-02
Gluconeogenesis	24	2.49e-02	5.83e-02	0.32200	-0.035100	0.321000	7.66e-01	6.59e-03
Negative regulation of MET activity	17	7.90e-02	1.49e-01	0.32200	0.090500	-0.309000	5.18e-01	2.73e-02
Basigin interactions	14	1.28e-01	2.16e-01	0.32200	-0.298000	0.123000	5.37e-02	4.26e-01
Cell recruitment (pro-inflammatory response)	15	9.73e-02	1.77e-01	0.32200	0.013600	-0.322000	9.27e-01	3.11e-02
Purinergic signaling in leishmaniasis infection	15	9.73e-02	1.77e-01	0.32200	0.013600	-0.322000	9.27e-01	3.11e-02
Degradation of cysteine and homocysteine	10	1.88e-01	2.91e-01	0.32100	-0.152000	-0.283000	4.06e-01	1.22e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	69	1.26e-05	7.70e-05	0.32100	0.111000	0.301000	1.10e-01	1.62e-05
Assembly Of The HIV Virion	14	1.38e-01	2.28e-01	0.32100	0.247000	-0.205000	1.10e-01	1.85e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	7.90e-02	1.49e-01	0.32000	0.042900	0.318000	7.67e-01	2.79e-02
Nephrin family interactions	14	1.28e-01	2.16e-01	0.31900	0.307000	-0.087100	4.66e-02	5.73e-01
NIK–>noncanonical NF-kB signaling	52	4.39e-04	1.89e-03	0.31900	-0.048200	0.315000	5.48e-01	8.71e-05
Protein methylation	12	1.36e-01	2.27e-01	0.31800	0.192000	0.254000	2.51e-01	1.28e-01
DARPP-32 events	21	4.18e-02	8.94e-02	0.31800	0.015900	-0.318000	9.00e-01	1.18e-02
Metabolism of nitric oxide: NOS3 activation and regulation	12	1.76e-01	2.76e-01	0.31800	0.092700	-0.304000	5.78e-01	6.83e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	8.84e-02	1.64e-01	0.31800	-0.010100	0.318000	9.44e-01	2.79e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	8.84e-02	1.64e-01	0.31800	-0.010100	0.318000	9.44e-01	2.79e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	22	4.30e-02	9.11e-02	0.31600	-0.098300	0.301000	4.25e-01	1.47e-02
RUNX2 regulates osteoblast differentiation	14	1.06e-01	1.91e-01	0.31600	0.295000	0.114000	5.60e-02	4.61e-01
Nuclear events mediated by NFE2L2	69	3.63e-05	2.01e-04	0.31600	-0.020400	0.315000	7.70e-01	6.17e-06
Base-Excision Repair, AP Site Formation	15	1.11e-01	1.97e-01	0.31600	-0.044700	0.313000	7.65e-01	3.62e-02
Integrin cell surface interactions	25	3.23e-02	7.22e-02	0.31500	0.181000	-0.258000	1.17e-01	2.56e-02
DCC mediated attractive signaling	11	1.85e-01	2.87e-01	0.31500	0.312000	0.041400	7.27e-02	8.12e-01
HIV Life Cycle	130	7.55e-09	9.27e-08	0.31500	-0.053500	0.310000	2.94e-01	1.10e-09
TP53 Regulates Transcription of Cell Cycle Genes	43	1.44e-03	5.26e-03	0.31400	0.042400	0.311000	6.31e-01	4.17e-04
RNA Polymerase II Pre-transcription Events	69	4.79e-05	2.58e-04	0.31400	-0.043200	0.311000	5.36e-01	8.40e-06
Regulation of RUNX3 expression and activity	50	5.55e-04	2.33e-03	0.31300	0.034300	0.311000	6.75e-01	1.47e-04
Cleavage of the damaged pyrimidine	14	1.27e-01	2.15e-01	0.31100	0.010000	0.311000	9.48e-01	4.38e-02
Depyrimidination	14	1.27e-01	2.15e-01	0.31100	0.010000	0.311000	9.48e-01	4.38e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	1.27e-01	2.15e-01	0.31100	0.010000	0.311000	9.48e-01	4.38e-02
G-protein mediated events	33	8.47e-03	2.34e-02	0.31100	0.017600	-0.311000	8.61e-01	2.02e-03
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	2.51e-01	3.57e-01	0.31100	0.294000	-0.101000	1.07e-01	5.81e-01
Dectin-1 mediated noncanonical NF-kB signaling	53	5.63e-04	2.35e-03	0.31000	-0.045500	0.307000	5.67e-01	1.12e-04
Lysosome Vesicle Biogenesis	26	2.19e-02	5.30e-02	0.30900	-0.032400	-0.308000	7.75e-01	6.65e-03
Interferon alpha/beta signaling	50	5.93e-04	2.47e-03	0.30900	-0.056300	-0.304000	4.91e-01	2.02e-04
HSF1 activation	22	3.40e-02	7.50e-02	0.30900	0.124000	0.283000	3.13e-01	2.16e-02
Late Phase of HIV Life Cycle	118	8.36e-08	8.35e-07	0.30900	-0.054900	0.304000	3.04e-01	1.31e-08
Regulation of RUNX2 expression and activity	58	2.90e-04	1.30e-03	0.30800	-0.028000	0.307000	7.13e-01	5.42e-05
Signaling by Non-Receptor Tyrosine Kinases	36	9.22e-03	2.53e-02	0.30800	0.224000	-0.211000	2.00e-02	2.85e-02
Signaling by PTK6	36	9.22e-03	2.53e-02	0.30800	0.224000	-0.211000	2.00e-02	2.85e-02
Assembly of collagen fibrils and other multimeric structures	15	9.79e-02	1.77e-01	0.30800	0.171000	0.256000	2.51e-01	8.65e-02
Degradation of AXIN	48	1.34e-03	4.94e-03	0.30800	-0.058900	0.302000	4.81e-01	2.98e-04
G-protein beta:gamma signalling	22	4.19e-02	8.94e-02	0.30700	-0.018400	-0.307000	8.81e-01	1.28e-02
Regulation of RAS by GAPs	57	3.73e-04	1.62e-03	0.30700	-0.044400	0.304000	5.63e-01	7.27e-05
Gastrin-CREB signalling pathway via PKC and MAPK	13	1.53e-01	2.49e-01	0.30700	-0.020800	-0.307000	8.97e-01	5.58e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	2.46e-01	3.54e-01	0.30700	-0.306000	0.025700	9.41e-02	8.88e-01
SHC1 events in ERBB2 signaling	12	2.04e-01	3.11e-01	0.30600	0.125000	-0.280000	4.53e-01	9.34e-02
Binding and Uptake of Ligands by Scavenger Receptors	10	2.48e-01	3.55e-01	0.30600	-0.026800	0.305000	8.83e-01	9.48e-02
TBC/RABGAPs	40	3.01e-03	1.02e-02	0.30600	-0.054300	-0.301000	5.53e-01	1.01e-03
Signaling by ROBO receptors	160	5.33e-10	9.09e-09	0.30500	-0.062500	0.298000	1.74e-01	8.70e-11
Degradation of GLI1 by the proteasome	52	7.25e-04	2.90e-03	0.30500	-0.007900	0.305000	9.22e-01	1.48e-04
Asymmetric localization of PCP proteins	52	7.85e-04	3.09e-03	0.30500	-0.025900	0.304000	7.46e-01	1.56e-04
EGR2 and SOX10-mediated initiation of Schwann cell myelination	14	1.18e-01	2.05e-01	0.30400	-0.229000	-0.200000	1.37e-01	1.95e-01
Rap1 signalling	11	2.32e-01	3.39e-01	0.30300	0.080500	-0.293000	6.44e-01	9.31e-02
HDACs deacetylate histones	29	1.25e-02	3.30e-02	0.30300	0.230000	0.198000	3.25e-02	6.49e-02
B-WICH complex positively regulates rRNA expression	27	2.90e-02	6.64e-02	0.30300	-0.094800	0.288000	3.94e-01	9.70e-03
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	9.91e-02	1.79e-01	0.30300	0.076800	0.293000	5.95e-01	4.26e-02
Synaptic adhesion-like molecules	10	2.76e-01	3.85e-01	0.30200	-0.115000	0.279000	5.30e-01	1.27e-01
Pausing and recovery of Tat-mediated HIV elongation	26	3.27e-02	7.22e-02	0.30100	-0.062300	0.294000	5.83e-01	9.43e-03
Tat-mediated HIV elongation arrest and recovery	26	3.27e-02	7.22e-02	0.30100	-0.062300	0.294000	5.83e-01	9.43e-03
RMTs methylate histone arginines	27	2.20e-02	5.33e-02	0.30000	0.064800	0.293000	5.60e-01	8.36e-03
Collagen degradation	14	1.60e-01	2.56e-01	0.30000	0.293000	-0.066200	5.77e-02	6.68e-01
RNA polymerase II transcribes snRNA genes	64	2.47e-04	1.12e-03	0.30000	-0.073100	0.291000	3.13e-01	5.74e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	54	9.14e-04	3.51e-03	0.30000	-0.074100	0.291000	3.47e-01	2.24e-04
MAPK6/MAPK4 signaling	69	9.44e-05	4.79e-04	0.30000	-0.006790	0.300000	9.22e-01	1.74e-05
Signaling by NOTCH2	18	1.02e-01	1.84e-01	0.29900	0.105000	-0.280000	4.42e-01	4.01e-02
A tetrasaccharide linker sequence is required for GAG synthesis	10	2.44e-01	3.53e-01	0.29900	0.081400	0.287000	6.56e-01	1.16e-01
Amino acid transport across the plasma membrane	17	1.14e-01	2.00e-01	0.29800	-0.287000	0.080000	4.06e-02	5.68e-01
TICAM1-dependent activation of IRF3/IRF7	12	2.07e-01	3.14e-01	0.29700	0.296000	-0.030000	7.61e-02	8.57e-01
SUMOylation of intracellular receptors	19	7.44e-02	1.43e-01	0.29700	-0.045600	-0.294000	7.31e-01	2.68e-02
Prolonged ERK activation events	13	1.58e-01	2.55e-01	0.29600	-0.126000	-0.268000	4.31e-01	9.43e-02
Platelet activation, signaling and aggregation	139	2.32e-08	2.59e-07	0.29600	0.051000	-0.291000	3.01e-01	3.47e-09
GABA receptor activation	19	9.53e-02	1.74e-01	0.29600	0.110000	-0.274000	4.08e-01	3.85e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	58	6.07e-04	2.52e-03	0.29600	-0.046500	0.292000	5.41e-01	1.23e-04
Mitotic Prophase	77	5.67e-05	3.00e-04	0.29500	-0.052100	0.291000	4.30e-01	1.06e-05
Regulation of insulin secretion	40	3.43e-03	1.14e-02	0.29500	-0.153000	-0.253000	9.49e-02	5.71e-03
NGF-stimulated transcription	25	4.89e-02	1.01e-01	0.29500	0.155000	-0.251000	1.79e-01	3.01e-02
G-protein activation	12	1.80e-01	2.81e-01	0.29500	-0.207000	-0.210000	2.15e-01	2.08e-01
Defective Intrinsic Pathway for Apoptosis	23	3.86e-02	8.33e-02	0.29400	0.158000	0.248000	1.88e-01	3.95e-02
Role of phospholipids in phagocytosis	16	1.40e-01	2.31e-01	0.29400	0.099600	-0.277000	4.90e-01	5.56e-02
Attenuation phase	19	7.11e-02	1.38e-01	0.29400	0.122000	0.267000	3.56e-01	4.39e-02
Sphingolipid de novo biosynthesis	23	6.25e-02	1.24e-01	0.29400	0.259000	-0.140000	3.19e-02	2.47e-01
PIWI-interacting RNA (piRNA) biogenesis	16	1.29e-01	2.16e-01	0.29400	-0.026700	0.293000	8.53e-01	4.29e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	3.73e-02	8.10e-02	0.29200	-0.092300	0.277000	4.07e-01	1.27e-02
ATF4 activates genes in response to endoplasmic reticulum stress	23	6.65e-02	1.30e-01	0.29200	-0.169000	0.238000	1.61e-01	4.80e-02
RHO GTPases activate PAKs	14	1.82e-01	2.84e-01	0.29200	0.275000	-0.096900	7.45e-02	5.30e-01
Maturation of nucleoprotein	11	2.19e-01	3.26e-01	0.29200	-0.260000	-0.133000	1.35e-01	4.47e-01
HIV Infection	194	4.34e-11	8.78e-10	0.29200	-0.042000	0.288000	3.16e-01	5.30e-12
FCGR3A-mediated phagocytosis	45	5.07e-03	1.56e-02	0.29100	0.158000	-0.245000	6.70e-02	4.53e-03
Leishmania phagocytosis	45	5.07e-03	1.56e-02	0.29100	0.158000	-0.245000	6.70e-02	4.53e-03
Parasite infection	45	5.07e-03	1.56e-02	0.29100	0.158000	-0.245000	6.70e-02	4.53e-03
Recycling pathway of L1	19	1.09e-01	1.95e-01	0.29100	0.180000	-0.228000	1.75e-01	8.49e-02
Meiotic synapsis	26	3.14e-02	7.09e-02	0.29000	0.083700	0.278000	4.60e-01	1.43e-02
RHOU GTPase cycle	35	1.51e-02	3.83e-02	0.29000	0.091600	-0.275000	3.49e-01	4.90e-03
RHOC GTPase cycle	50	2.25e-03	7.95e-03	0.28900	0.053700	-0.284000	5.11e-01	5.12e-04
Sema3A PAK dependent Axon repulsion	11	2.25e-01	3.31e-01	0.28900	0.252000	0.142000	1.48e-01	4.17e-01
Signaling by ERBB2	34	2.05e-02	5.05e-02	0.28900	0.210000	-0.198000	3.41e-02	4.61e-02
SUMOylation	141	1.55e-08	1.78e-07	0.28800	0.047400	0.284000	3.33e-01	6.31e-09
EPHB-mediated forward signaling	25	4.29e-02	9.10e-02	0.28800	0.287000	0.013200	1.29e-02	9.09e-01
Telomere Extension By Telomerase	21	7.36e-02	1.42e-01	0.28700	-0.005600	0.287000	9.65e-01	2.27e-02
Apoptotic cleavage of cellular proteins	26	5.27e-02	1.07e-01	0.28700	0.210000	-0.196000	6.43e-02	8.39e-02
Negative regulation of FGFR1 signaling	18	1.24e-01	2.11e-01	0.28600	0.107000	-0.266000	4.33e-01	5.10e-02
Negative regulation of FGFR2 signaling	18	1.24e-01	2.11e-01	0.28600	0.107000	-0.266000	4.33e-01	5.10e-02
Negative regulation of FGFR3 signaling	18	1.24e-01	2.11e-01	0.28600	0.107000	-0.266000	4.33e-01	5.10e-02
Negative regulation of FGFR4 signaling	18	1.24e-01	2.11e-01	0.28600	0.107000	-0.266000	4.33e-01	5.10e-02
Aquaporin-mediated transport	24	4.79e-02	9.91e-02	0.28600	-0.038700	-0.284000	7.43e-01	1.62e-02
Muscle contraction	65	5.58e-04	2.34e-03	0.28600	0.108000	-0.265000	1.32e-01	2.28e-04
Formation of TC-NER Pre-Incision Complex	45	3.19e-03	1.07e-02	0.28600	0.064900	0.278000	4.51e-01	1.26e-03
Oncogenic MAPK signaling	58	9.22e-04	3.53e-03	0.28500	0.027000	-0.284000	7.23e-01	1.85e-04
AURKA Activation by TPX2	61	6.30e-04	2.59e-03	0.28500	-0.017500	0.285000	8.13e-01	1.24e-04
TNFR1-induced proapoptotic signaling	12	2.16e-01	3.24e-01	0.28500	-0.065500	-0.277000	6.94e-01	9.63e-02
HIV elongation arrest and recovery	27	4.19e-02	8.94e-02	0.28500	-0.061800	0.278000	5.79e-01	1.25e-02
Pausing and recovery of HIV elongation	27	4.19e-02	8.94e-02	0.28500	-0.061800	0.278000	5.79e-01	1.25e-02
Opioid Signalling	58	9.82e-04	3.71e-03	0.28400	0.029200	-0.283000	7.01e-01	1.98e-04
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	19	9.74e-02	1.77e-01	0.28300	0.017400	0.283000	8.96e-01	3.29e-02
Pexophagy	11	2.92e-01	4.05e-01	0.28300	0.136000	-0.248000	4.33e-01	1.54e-01
RNA Polymerase III Chain Elongation	17	1.21e-01	2.08e-01	0.28300	0.044200	0.280000	7.52e-01	4.60e-02
Kinesins	33	2.35e-02	5.57e-02	0.28200	-0.090700	0.267000	3.67e-01	7.89e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	5.21e-02	1.06e-01	0.28200	-0.089600	0.268000	4.29e-01	1.83e-02
Class B/2 (Secretin family receptors)	27	4.53e-02	9.48e-02	0.28200	0.272000	-0.073700	1.44e-02	5.08e-01
Activation of NF-kappaB in B cells	59	8.46e-04	3.30e-03	0.28200	0.007980	0.282000	9.16e-01	1.87e-04
Apoptotic factor-mediated response	17	1.12e-01	1.99e-01	0.28200	0.250000	0.130000	7.44e-02	3.55e-01
Interleukin-4 and Interleukin-13 signaling	50	3.16e-03	1.07e-02	0.28100	0.051200	-0.276000	5.31e-01	7.31e-04
Interleukin-17 signaling	55	2.03e-03	7.22e-03	0.28100	0.083700	-0.268000	2.84e-01	5.89e-04
Nicotinate metabolism	18	1.00e-01	1.80e-01	0.28000	-0.244000	-0.138000	7.32e-02	3.10e-01
Response to elevated platelet cytosolic Ca2+	59	1.24e-03	4.61e-03	0.28000	0.063400	-0.273000	4.00e-01	2.94e-04
Erythropoietin activates RAS	11	2.49e-01	3.55e-01	0.28000	-0.256000	-0.115000	1.42e-01	5.11e-01
RIP-mediated NFkB activation via ZBP1	15	1.65e-01	2.63e-01	0.28000	-0.026100	-0.279000	8.61e-01	6.17e-02
LDL clearance	13	2.47e-01	3.55e-01	0.27900	0.184000	-0.210000	2.51e-01	1.89e-01
Signaling by NTRK2 (TRKB)	16	1.30e-01	2.18e-01	0.27900	0.234000	0.152000	1.05e-01	2.92e-01
COPI-dependent Golgi-to-ER retrograde traffic	67	6.14e-04	2.54e-03	0.27800	-0.086200	0.265000	2.23e-01	1.83e-04
ERKs are inactivated	12	2.65e-01	3.75e-01	0.27800	0.087700	-0.264000	5.99e-01	1.14e-01
Signaling by FGFR2 in disease	25	5.61e-02	1.13e-01	0.27700	-0.009930	0.277000	9.32e-01	1.65e-02
Interleukin-20 family signaling	13	2.05e-01	3.12e-01	0.27700	-0.081500	-0.265000	6.11e-01	9.82e-02
Activation of GABAB receptors	17	1.58e-01	2.54e-01	0.27600	0.092500	-0.260000	5.09e-01	6.33e-02
GABA B receptor activation	17	1.58e-01	2.54e-01	0.27600	0.092500	-0.260000	5.09e-01	6.33e-02
Cardiac conduction	42	1.01e-02	2.75e-02	0.27600	0.075400	-0.266000	3.98e-01	2.93e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	35	2.14e-02	5.22e-02	0.27600	0.267000	-0.068600	6.24e-03	4.83e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	2.66e-01	3.75e-01	0.27500	0.058400	-0.269000	7.26e-01	1.07e-01
RHOBTB2 GTPase cycle	21	7.93e-02	1.49e-01	0.27500	0.091800	0.259000	4.67e-01	3.97e-02
Thrombin signalling through proteinase activated receptors (PARs)	19	1.12e-01	1.99e-01	0.27500	-0.015800	-0.274000	9.05e-01	3.85e-02
Signaling by WNT in cancer	25	7.51e-02	1.44e-01	0.27400	0.182000	-0.205000	1.15e-01	7.56e-02
APC/C:Cdc20 mediated degradation of Cyclin B	22	9.08e-02	1.67e-01	0.27400	-0.059000	0.268000	6.32e-01	2.99e-02
Trafficking and processing of endosomal TLR	10	3.40e-01	4.59e-01	0.27400	0.263000	-0.076600	1.50e-01	6.75e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	2.54e-02	5.92e-02	0.27400	-0.020500	0.273000	8.39e-01	6.72e-03
Platelet degranulation	55	2.77e-03	9.46e-03	0.27300	0.076800	-0.262000	3.25e-01	7.73e-04
Formation of RNA Pol II elongation complex	49	4.61e-03	1.45e-02	0.27300	-0.036100	0.271000	6.62e-01	1.05e-03
RNA Polymerase II Transcription Elongation	49	4.61e-03	1.45e-02	0.27300	-0.036100	0.271000	6.62e-01	1.05e-03
Regulation of TP53 Activity	139	1.91e-07	1.76e-06	0.27100	0.019000	0.271000	6.99e-01	3.97e-08
Receptor Mediated Mitophagy	10	3.02e-01	4.17e-01	0.27100	0.238000	0.131000	1.93e-01	4.74e-01
Intraflagellar transport	33	3.26e-02	7.22e-02	0.27000	0.089700	-0.255000	3.73e-01	1.14e-02
Diseases of mitotic cell cycle	35	2.21e-02	5.34e-02	0.27000	-0.013100	0.270000	8.94e-01	5.80e-03
Nucleotide salvage	19	1.47e-01	2.41e-01	0.27000	-0.224000	0.151000	9.15e-02	2.55e-01
SUMO E3 ligases SUMOylate target proteins	135	3.32e-07	2.89e-06	0.26900	0.033900	0.267000	4.98e-01	9.41e-08
DNA Damage/Telomere Stress Induced Senescence	24	6.83e-02	1.34e-01	0.26900	0.039100	0.266000	7.40e-01	2.42e-02
Platelet homeostasis	48	5.16e-03	1.59e-02	0.26800	-0.018500	-0.268000	8.24e-01	1.35e-03
TNFR2 non-canonical NF-kB pathway	69	7.46e-04	2.96e-03	0.26800	-0.052800	0.263000	4.49e-01	1.62e-04
Telomere C-strand synthesis initiation	11	2.81e-01	3.91e-01	0.26800	0.106000	0.246000	5.44e-01	1.58e-01
Constitutive Signaling by EGFRvIII	11	2.76e-01	3.85e-01	0.26800	0.229000	0.138000	1.88e-01	4.27e-01
Signaling by EGFRvIII in Cancer	11	2.76e-01	3.85e-01	0.26800	0.229000	0.138000	1.88e-01	4.27e-01
Integration of energy metabolism	60	1.13e-03	4.21e-03	0.26600	-0.095800	-0.249000	2.00e-01	8.82e-04
PI Metabolism	63	8.89e-04	3.43e-03	0.26600	-0.070200	-0.257000	3.36e-01	4.28e-04
GPER1 signaling	24	8.07e-02	1.51e-01	0.26600	0.029500	-0.265000	8.03e-01	2.49e-02
ZBP1(DAI) mediated induction of type I IFNs	18	1.37e-01	2.28e-01	0.26600	-0.051200	-0.261000	7.07e-01	5.54e-02
RNA Polymerase III Transcription Initiation	35	2.81e-02	6.47e-02	0.26500	-0.057800	0.259000	5.55e-01	8.07e-03
MAP kinase activation	53	5.20e-03	1.60e-02	0.26500	0.094800	-0.247000	2.33e-01	1.87e-03
Signaling by EGFR	37	2.80e-02	6.46e-02	0.26500	0.214000	-0.156000	2.44e-02	1.01e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	2.36e-01	3.43e-01	0.26500	0.193000	-0.181000	1.95e-01	2.26e-01
Synthesis of PIPs at the early endosome membrane	13	2.34e-01	3.42e-01	0.26400	-0.095500	-0.246000	5.51e-01	1.25e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	76	5.12e-04	2.17e-03	0.26400	0.071300	-0.254000	2.83e-01	1.32e-04
Toll Like Receptor 2 (TLR2) Cascade	76	5.12e-04	2.17e-03	0.26400	0.071300	-0.254000	2.83e-01	1.32e-04
Toll Like Receptor TLR1:TLR2 Cascade	76	5.12e-04	2.17e-03	0.26400	0.071300	-0.254000	2.83e-01	1.32e-04
Toll Like Receptor TLR6:TLR2 Cascade	76	5.12e-04	2.17e-03	0.26400	0.071300	-0.254000	2.83e-01	1.32e-04
GPCR downstream signalling	194	4.27e-09	5.52e-08	0.26300	0.049500	-0.258000	2.37e-01	6.57e-10
Nuclear events stimulated by ALK signaling in cancer	16	2.12e-01	3.19e-01	0.26200	0.104000	-0.241000	4.70e-01	9.58e-02
Collagen formation	27	4.78e-02	9.91e-02	0.26200	0.158000	0.209000	1.55e-01	6.03e-02
Purine salvage	12	3.18e-01	4.35e-01	0.26100	-0.124000	0.230000	4.55e-01	1.68e-01
DNA Damage Bypass	44	8.16e-03	2.27e-02	0.26100	0.100000	0.241000	2.51e-01	5.66e-03
ISG15 antiviral mechanism	70	1.30e-03	4.82e-03	0.26100	-0.119000	0.232000	8.51e-02	7.97e-04
Post-translational protein phosphorylation	34	3.47e-02	7.63e-02	0.26100	0.255000	-0.056000	1.01e-02	5.72e-01
Constitutive Signaling by Aberrant PI3K in Cancer	28	6.96e-02	1.36e-01	0.26100	0.115000	-0.234000	2.91e-01	3.24e-02
ADORA2B mediated anti-inflammatory cytokines production	33	4.45e-02	9.36e-02	0.26000	0.131000	-0.225000	1.93e-01	2.54e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	16	1.90e-01	2.93e-01	0.26000	0.260000	0.019800	7.22e-02	8.91e-01
G alpha (12/13) signalling events	44	1.23e-02	3.25e-02	0.26000	0.024800	-0.259000	7.76e-01	3.02e-03
Inositol phosphate metabolism	30	5.80e-02	1.16e-01	0.25900	0.095100	-0.241000	3.68e-01	2.25e-02
ABC transporter disorders	61	2.37e-03	8.21e-03	0.25900	-0.022800	0.258000	7.58e-01	5.06e-04
Smooth Muscle Contraction	18	1.83e-01	2.85e-01	0.25900	0.105000	-0.237000	4.40e-01	8.25e-02
Iron uptake and transport	39	1.92e-02	4.80e-02	0.25900	-0.006280	-0.259000	9.46e-01	5.23e-03
Plasma lipoprotein clearance	25	9.89e-02	1.79e-01	0.25900	0.147000	-0.213000	2.03e-01	6.57e-02
Metabolism of amino acids and derivatives	231	6.03e-10	9.87e-09	0.25900	-0.114000	0.232000	3.00e-03	1.53e-09
NRIF signals cell death from the nucleus	14	2.20e-01	3.27e-01	0.25800	-0.120000	-0.229000	4.37e-01	1.38e-01
Cytosolic sulfonation of small molecules	10	3.44e-01	4.63e-01	0.25800	-0.241000	-0.091100	1.86e-01	6.18e-01
Nucleotide Excision Repair	100	2.88e-05	1.65e-04	0.25800	0.072600	0.248000	2.11e-01	1.97e-05
Anti-inflammatory response favouring Leishmania parasite infection	54	5.96e-03	1.75e-02	0.25800	0.078000	-0.246000	3.22e-01	1.81e-03
Leishmania parasite growth and survival	54	5.96e-03	1.75e-02	0.25800	0.078000	-0.246000	3.22e-01	1.81e-03
Synthesis of PIPs at the plasma membrane	39	1.99e-02	4.95e-02	0.25800	-0.004340	-0.258000	9.63e-01	5.39e-03
Plasma lipoprotein assembly, remodeling, and clearance	41	2.38e-02	5.59e-02	0.25800	0.163000	-0.199000	7.09e-02	2.74e-02
TNFR1-induced NFkappaB signaling pathway	22	1.20e-01	2.07e-01	0.25800	0.052300	-0.252000	6.71e-01	4.07e-02
Late endosomal microautophagy	24	1.07e-01	1.92e-01	0.25700	0.108000	-0.233000	3.58e-01	4.79e-02
Interleukin-2 family signaling	30	4.53e-02	9.49e-02	0.25700	-0.052400	-0.252000	6.19e-01	1.72e-02
Interleukin-7 signaling	15	2.27e-01	3.35e-01	0.25700	0.013700	-0.257000	9.27e-01	8.55e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	12	2.96e-01	4.09e-01	0.25700	0.255000	0.028800	1.26e-01	8.63e-01
STAT3 nuclear events downstream of ALK signaling	10	3.61e-01	4.81e-01	0.25600	0.038000	0.254000	8.35e-01	1.65e-01
Elastic fibre formation	17	1.66e-01	2.65e-01	0.25600	-0.098200	-0.237000	4.84e-01	9.10e-02
Interconversion of nucleotide di- and triphosphates	24	7.86e-02	1.48e-01	0.25600	0.108000	0.232000	3.58e-01	4.90e-02
Global Genome Nucleotide Excision Repair (GG-NER)	78	2.79e-04	1.26e-03	0.25600	0.103000	0.235000	1.17e-01	3.52e-04
Signaling by cytosolic FGFR1 fusion mutants	17	1.87e-01	2.90e-01	0.25600	0.001710	-0.256000	9.90e-01	6.80e-02
Regulation of TNFR1 signaling	32	5.19e-02	1.06e-01	0.25500	0.086000	-0.240000	4.00e-01	1.89e-02
Inhibition of DNA recombination at telomere	19	1.51e-01	2.46e-01	0.25500	0.021200	0.254000	8.73e-01	5.53e-02
Phospholipid metabolism	137	1.32e-06	9.83e-06	0.25500	-0.030000	-0.253000	5.45e-01	3.52e-07
G beta:gamma signalling through BTK	11	3.24e-01	4.42e-01	0.25300	-0.082500	-0.240000	6.35e-01	1.69e-01
Activation of BH3-only proteins	27	7.80e-02	1.48e-01	0.25300	-0.030500	0.251000	7.84e-01	2.40e-02
RHO GTPases Activate WASPs and WAVEs	31	6.44e-02	1.27e-01	0.25300	0.140000	-0.211000	1.77e-01	4.27e-02
Nuclear Receptor transcription pathway	27	7.78e-02	1.48e-01	0.25300	0.025200	-0.251000	8.21e-01	2.38e-02
Amino acids regulate mTORC1	44	1.33e-02	3.46e-02	0.25200	-0.034200	-0.250000	6.95e-01	4.15e-03
Frs2-mediated activation	11	3.21e-01	4.38e-01	0.25200	-0.132000	-0.214000	4.47e-01	2.19e-01
Class I peroxisomal membrane protein import	20	1.49e-01	2.43e-01	0.25100	-0.007750	-0.251000	9.52e-01	5.25e-02
Collagen biosynthesis and modifying enzymes	17	1.78e-01	2.79e-01	0.25000	0.121000	0.219000	3.89e-01	1.18e-01
Signaling by ERBB2 ECD mutants	11	3.28e-01	4.46e-01	0.25000	0.223000	0.113000	2.00e-01	5.17e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	1.17e-01	2.04e-01	0.25000	0.165000	-0.188000	1.54e-01	1.04e-01
Leishmania infection	115	3.54e-05	1.97e-04	0.24900	0.055600	-0.243000	3.04e-01	7.35e-06
Disorders of transmembrane transporters	115	3.86e-05	2.10e-04	0.24900	-0.065600	0.240000	2.26e-01	9.28e-06
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	36	3.22e-02	7.22e-02	0.24800	0.036800	0.246000	7.02e-01	1.08e-02
Loss of Nlp from mitotic centrosomes	58	4.87e-03	1.51e-02	0.24800	-0.012700	0.248000	8.67e-01	1.11e-03
Loss of proteins required for interphase microtubule organization from the centrosome	58	4.87e-03	1.51e-02	0.24800	-0.012700	0.248000	8.67e-01	1.11e-03
G alpha (i) signalling events	90	2.96e-04	1.32e-03	0.24800	0.029200	-0.246000	6.33e-01	5.58e-05
ABC-family proteins mediated transport	78	9.04e-04	3.48e-03	0.24800	-0.034600	0.245000	5.98e-01	1.85e-04
Signaling by NODAL	12	3.56e-01	4.76e-01	0.24800	0.109000	-0.222000	5.13e-01	1.83e-01
Regulation of localization of FOXO transcription factors	10	3.66e-01	4.84e-01	0.24700	0.200000	0.146000	2.74e-01	4.24e-01
HCMV Late Events	51	1.18e-02	3.14e-02	0.24700	-0.080800	0.234000	3.18e-01	3.91e-03
Signaling by FGFR1	29	8.70e-02	1.62e-01	0.24700	0.190000	-0.159000	7.72e-02	1.39e-01
PKMTs methylate histone lysines	33	3.66e-02	8.02e-02	0.24700	0.173000	0.176000	8.54e-02	8.02e-02
Azathioprine ADME	16	2.18e-01	3.25e-01	0.24600	0.055700	0.240000	7.00e-01	9.65e-02
Regulation of PTEN stability and activity	58	5.43e-03	1.64e-02	0.24600	-0.019800	0.246000	7.94e-01	1.24e-03
Degradation of the extracellular matrix	36	4.81e-02	9.95e-02	0.24600	0.212000	-0.125000	2.78e-02	1.94e-01
KEAP1-NFE2L2 pathway	88	3.11e-04	1.37e-03	0.24600	0.013500	0.246000	8.28e-01	6.97e-05
Caspase activation via extrinsic apoptotic signalling pathway	16	2.62e-01	3.71e-01	0.24600	0.131000	-0.208000	3.66e-01	1.50e-01
Protein ubiquitination	61	5.37e-03	1.64e-02	0.24500	-0.077700	0.233000	2.94e-01	1.69e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	3.67e-01	4.85e-01	0.24500	0.128000	-0.209000	4.42e-01	2.10e-01
SLC transporter disorders	54	1.11e-02	2.96e-02	0.24500	-0.113000	0.217000	1.51e-01	5.90e-03
Phase I - Functionalization of compounds	30	7.49e-02	1.44e-01	0.24500	0.059000	-0.237000	5.76e-01	2.46e-02
Molecules associated with elastic fibres	12	3.37e-01	4.55e-01	0.24400	-0.007000	-0.244000	9.67e-01	1.43e-01
Notch-HLH transcription pathway	22	1.57e-01	2.54e-01	0.24400	0.101000	-0.223000	4.13e-01	7.09e-02
Inactivation, recovery and regulation of the phototransduction cascade	17	1.90e-01	2.93e-01	0.24400	0.155000	0.188000	2.68e-01	1.79e-01
Ras activation upon Ca2+ influx through NMDA receptor	10	4.23e-01	5.38e-01	0.24300	-0.049900	0.238000	7.85e-01	1.93e-01
Signaling by KIT in disease	17	2.14e-01	3.21e-01	0.24300	0.242000	0.025800	8.47e-02	8.54e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	17	2.14e-01	3.21e-01	0.24300	0.242000	0.025800	8.47e-02	8.54e-01
NOTCH4 Intracellular Domain Regulates Transcription	14	2.90e-01	4.02e-01	0.24300	0.007900	-0.243000	9.59e-01	1.16e-01
Signaling by PDGF	26	1.14e-01	2.00e-01	0.24300	0.226000	-0.089600	4.65e-02	4.29e-01
Signaling by Erythropoietin	20	1.71e-01	2.69e-01	0.24200	-0.002170	-0.242000	9.87e-01	6.12e-02
Energy dependent regulation of mTOR by LKB1-AMPK	27	8.24e-02	1.54e-01	0.24200	-0.069400	-0.232000	5.33e-01	3.74e-02
Signaling by ERBB4	32	7.78e-02	1.48e-01	0.24100	0.191000	-0.146000	6.12e-02	1.53e-01
Respiratory electron transport	85	6.42e-04	2.63e-03	0.24000	-0.002720	0.240000	9.65e-01	1.32e-04
HCMV Infection	72	2.68e-03	9.17e-03	0.24000	-0.070800	0.229000	3.00e-01	7.77e-04
FLT3 signaling in disease	25	1.38e-01	2.29e-01	0.23900	0.194000	-0.140000	9.27e-02	2.26e-01
SARS-CoV-2 modulates autophagy	11	4.01e-01	5.18e-01	0.23900	0.053100	-0.233000	7.60e-01	1.80e-01
FCERI mediated NF-kB activation	66	4.44e-03	1.41e-02	0.23900	-0.058600	0.232000	4.11e-01	1.16e-03
Signaling by GPCR	212	3.92e-08	4.22e-07	0.23900	0.066100	-0.229000	9.89e-02	1.02e-08
TRAF6 mediated IRF7 activation	16	2.32e-01	3.39e-01	0.23900	-0.223000	-0.086500	1.23e-01	5.50e-01
Gap junction trafficking and regulation	11	3.72e-01	4.90e-01	0.23800	0.228000	0.067500	1.90e-01	6.99e-01
PCP/CE pathway	73	1.62e-03	5.87e-03	0.23800	0.047500	0.233000	4.83e-01	5.83e-04
Metabolism of nucleotides	73	2.36e-03	8.21e-03	0.23800	-0.029800	0.236000	6.60e-01	5.09e-04
MyD88 cascade initiated on plasma membrane	69	3.84e-03	1.25e-02	0.23700	0.063000	-0.229000	3.66e-01	1.04e-03
Toll Like Receptor 10 (TLR10) Cascade	69	3.84e-03	1.25e-02	0.23700	0.063000	-0.229000	3.66e-01	1.04e-03
Toll Like Receptor 5 (TLR5) Cascade	69	3.84e-03	1.25e-02	0.23700	0.063000	-0.229000	3.66e-01	1.04e-03
FOXO-mediated transcription of cell death genes	15	3.13e-01	4.30e-01	0.23700	0.159000	-0.176000	2.87e-01	2.38e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	27	9.40e-02	1.72e-01	0.23700	0.044800	0.233000	6.87e-01	3.64e-02
trans-Golgi Network Vesicle Budding	54	7.82e-03	2.18e-02	0.23700	-0.089800	-0.219000	2.54e-01	5.35e-03
Glycogen synthesis	11	4.22e-01	5.38e-01	0.23600	-0.103000	0.213000	5.56e-01	2.22e-01
Rab regulation of trafficking	96	2.91e-04	1.31e-03	0.23600	-0.026000	-0.234000	6.60e-01	7.63e-05
Translation of Replicase and Assembly of the Replication Transcription Complex	11	3.68e-01	4.85e-01	0.23500	-0.154000	-0.178000	3.78e-01	3.06e-01
TNF signaling	39	4.57e-02	9.54e-02	0.23500	0.065900	-0.225000	4.77e-01	1.49e-02
Cytochrome c-mediated apoptotic response	12	3.59e-01	4.79e-01	0.23500	0.233000	0.031900	1.63e-01	8.48e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	1.65e-01	2.63e-01	0.23400	0.164000	0.167000	2.04e-01	1.97e-01
Neurodegenerative Diseases	20	1.65e-01	2.63e-01	0.23400	0.164000	0.167000	2.04e-01	1.97e-01
Thromboxane signalling through TP receptor	14	2.86e-01	3.97e-01	0.23300	-0.173000	-0.156000	2.62e-01	3.11e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	15	2.70e-01	3.78e-01	0.23300	0.211000	0.098600	1.58e-01	5.09e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	15	2.70e-01	3.78e-01	0.23300	0.211000	0.098600	1.58e-01	5.09e-01
Role of LAT2/NTAL/LAB on calcium mobilization	11	4.41e-01	5.56e-01	0.23300	0.174000	-0.155000	3.19e-01	3.74e-01
Toll Like Receptor 4 (TLR4) Cascade	99	3.61e-04	1.58e-03	0.23200	0.013600	-0.232000	8.16e-01	6.90e-05
Antiviral mechanism by IFN-stimulated genes	78	3.22e-03	1.08e-02	0.23200	-0.160000	0.168000	1.48e-02	1.04e-02
Glycerophospholipid biosynthesis	75	2.50e-03	8.63e-03	0.23200	0.010400	-0.231000	8.77e-01	5.44e-04
Pentose phosphate pathway	11	4.42e-01	5.57e-01	0.23200	-0.134000	0.189000	4.42e-01	2.78e-01
Downstream signal transduction	21	1.97e-01	3.02e-01	0.23200	0.224000	-0.058000	7.55e-02	6.45e-01
TRAF6 mediated NF-kB activation	20	1.74e-01	2.73e-01	0.23100	-0.136000	-0.187000	2.91e-01	1.48e-01
MyD88 dependent cascade initiated on endosome	71	4.76e-03	1.49e-02	0.23100	0.081400	-0.216000	2.36e-01	1.68e-03
Toll Like Receptor 7/8 (TLR7/8) Cascade	71	4.76e-03	1.49e-02	0.23100	0.081400	-0.216000	2.36e-01	1.68e-03
Formation of Incision Complex in GG-NER	37	4.20e-02	8.94e-02	0.23000	0.105000	0.205000	2.68e-01	3.13e-02
Complex I biogenesis	45	2.77e-02	6.43e-02	0.23000	0.002020	0.230000	9.81e-01	7.70e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	87	1.04e-03	3.92e-03	0.23000	-0.001240	0.230000	9.84e-01	2.22e-04
Formation of the beta-catenin:TCF transactivating complex	25	1.22e-01	2.09e-01	0.22900	0.214000	0.082000	6.37e-02	4.78e-01
O-linked glycosylation of mucins	26	1.21e-01	2.09e-01	0.22900	-0.028200	-0.228000	8.03e-01	4.46e-02
VxPx cargo-targeting to cilium	16	2.51e-01	3.57e-01	0.22900	-0.144000	-0.179000	3.20e-01	2.16e-01
RHOBTB GTPase Cycle	30	7.62e-02	1.46e-01	0.22900	0.191000	0.126000	7.00e-02	2.31e-01
RUNX2 regulates bone development	19	2.20e-01	3.27e-01	0.22900	0.229000	0.007410	8.41e-02	9.55e-01
Signaling by NTRK3 (TRKC)	12	3.59e-01	4.79e-01	0.22900	0.197000	0.116000	2.37e-01	4.85e-01
Fcgamma receptor (FCGR) dependent phagocytosis	65	9.24e-03	2.53e-02	0.22900	0.127000	-0.190000	7.64e-02	8.20e-03
Stimuli-sensing channels	42	4.40e-02	9.30e-02	0.22800	0.072000	-0.217000	4.20e-01	1.52e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	70	5.72e-03	1.70e-02	0.22800	0.068500	-0.217000	3.23e-01	1.72e-03
The role of Nef in HIV-1 replication and disease pathogenesis	20	2.41e-01	3.49e-01	0.22700	0.131000	-0.185000	3.12e-01	1.51e-01
Budding and maturation of HIV virion	24	1.55e-01	2.51e-01	0.22700	-0.003920	-0.227000	9.73e-01	5.47e-02
Deactivation of the beta-catenin transactivating complex	29	1.11e-01	1.97e-01	0.22600	0.225000	-0.018700	3.61e-02	8.62e-01
Pyruvate metabolism	22	2.15e-01	3.22e-01	0.22500	-0.126000	0.186000	3.08e-01	1.30e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	3.47e-01	4.66e-01	0.22500	-0.010900	0.224000	9.44e-01	1.46e-01
Cyclin D associated events in G1	41	3.73e-02	8.10e-02	0.22500	0.074400	0.212000	4.10e-01	1.90e-02
G1 Phase	41	3.73e-02	8.10e-02	0.22500	0.074400	0.212000	4.10e-01	1.90e-02
RUNX3 regulates NOTCH signaling	11	4.50e-01	5.65e-01	0.22500	0.059900	-0.216000	7.31e-01	2.14e-01
Signaling by ERBB2 in Cancer	14	3.64e-01	4.81e-01	0.22400	0.215000	-0.064100	1.64e-01	6.78e-01
Neutrophil degranulation	313	4.52e-11	8.94e-10	0.22400	-0.042100	-0.220000	2.05e-01	3.06e-11
SUMOylation of DNA methylation proteins	14	3.30e-01	4.47e-01	0.22400	0.060800	0.216000	6.94e-01	1.63e-01
Caspase activation via Death Receptors in the presence of ligand	10	4.41e-01	5.56e-01	0.22300	-0.137000	-0.176000	4.52e-01	3.35e-01
ECM proteoglycans	13	4.07e-01	5.23e-01	0.22300	0.195000	-0.108000	2.24e-01	5.01e-01
HSF1-dependent transactivation	25	1.43e-01	2.35e-01	0.22200	0.062200	0.213000	5.90e-01	6.53e-02
The phototransduction cascade	18	2.33e-01	3.39e-01	0.22200	0.152000	0.162000	2.64e-01	2.35e-01
Toll Like Receptor 9 (TLR9) Cascade	73	6.49e-03	1.89e-02	0.22200	0.087700	-0.204000	1.96e-01	2.68e-03
Sulfur amino acid metabolism	17	2.54e-01	3.61e-01	0.22100	-0.155000	-0.158000	2.69e-01	2.59e-01
Glucagon-type ligand receptors	13	4.11e-01	5.25e-01	0.22100	0.097900	-0.198000	5.41e-01	2.17e-01
Signaling by NOTCH1	52	3.06e-02	6.94e-02	0.22100	0.129000	-0.179000	1.09e-01	2.55e-02
Ion channel transport	86	2.30e-03	8.10e-03	0.22000	0.034100	-0.217000	5.85e-01	5.06e-04
Downregulation of SMAD2/3:SMAD4 transcriptional activity	25	1.90e-01	2.93e-01	0.22000	0.155000	-0.156000	1.81e-01	1.76e-01
Regulation of PLK1 Activity at G2/M Transition	76	3.54e-03	1.17e-02	0.22000	0.028300	0.218000	6.71e-01	1.03e-03
Termination of translesion DNA synthesis	29	1.17e-01	2.04e-01	0.22000	0.021400	0.218000	8.42e-01	4.19e-02
Toll-like Receptor Cascades	113	3.93e-04	1.71e-03	0.21900	0.043800	-0.215000	4.23e-01	8.35e-05
Keratan sulfate/keratin metabolism	18	3.05e-01	4.19e-01	0.21900	0.147000	-0.163000	2.82e-01	2.32e-01
G alpha (q) signalling events	74	4.43e-03	1.41e-02	0.21900	-0.022500	-0.218000	7.38e-01	1.23e-03
RIPK1-mediated regulated necrosis	27	1.34e-01	2.24e-01	0.21900	-0.040200	-0.215000	7.18e-01	5.34e-02
Regulation of necroptotic cell death	27	1.34e-01	2.24e-01	0.21900	-0.040200	-0.215000	7.18e-01	5.34e-02
Miscellaneous transport and binding events	16	3.39e-01	4.57e-01	0.21800	-0.205000	0.072900	1.55e-01	6.14e-01
MET promotes cell motility	13	4.29e-01	5.45e-01	0.21700	0.152000	-0.155000	3.41e-01	3.33e-01
CDC42 GTPase cycle	101	8.11e-04	3.18e-03	0.21700	0.004570	-0.217000	9.37e-01	1.67e-04
Cell-Cell communication	51	3.23e-02	7.22e-02	0.21700	0.065200	-0.207000	4.21e-01	1.06e-02
Toll Like Receptor 3 (TLR3) Cascade	78	5.56e-03	1.67e-02	0.21700	0.073700	-0.204000	2.61e-01	1.88e-03
Transport of vitamins, nucleosides, and related molecules	24	1.64e-01	2.62e-01	0.21700	-0.201000	-0.082000	8.90e-02	4.87e-01
RET signaling	24	2.14e-01	3.21e-01	0.21600	0.154000	-0.152000	1.92e-01	1.98e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	2.75e-01	3.85e-01	0.21600	0.019200	0.215000	8.88e-01	1.14e-01
Peroxisomal protein import	49	2.35e-02	5.57e-02	0.21600	-0.145000	-0.160000	7.96e-02	5.24e-02
RHOA GTPase cycle	97	9.51e-04	3.63e-03	0.21500	-0.039300	-0.212000	5.05e-01	3.23e-04
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	22	2.46e-01	3.54e-01	0.21500	-0.145000	0.159000	2.39e-01	1.97e-01
Downstream signaling events of B Cell Receptor (BCR)	72	6.79e-03	1.95e-02	0.21500	-0.001490	0.215000	9.83e-01	1.64e-03
FGFR1 mutant receptor activation	21	2.31e-01	3.39e-01	0.21500	-0.001360	-0.215000	9.91e-01	8.84e-02
Recruitment of NuMA to mitotic centrosomes	67	1.11e-02	2.97e-02	0.21500	-0.037800	0.211000	5.93e-01	2.81e-03
Interleukin-35 Signalling	11	4.34e-01	5.49e-01	0.21500	-0.154000	-0.150000	3.78e-01	3.89e-01
Triglyceride metabolism	18	3.18e-01	4.35e-01	0.21500	0.132000	-0.169000	3.32e-01	2.13e-01
RHO GTPases activate CIT	14	3.95e-01	5.13e-01	0.21500	0.207000	-0.058600	1.81e-01	7.04e-01
Cellular response to hypoxia	61	1.82e-02	4.59e-02	0.21500	-0.065000	0.205000	3.80e-01	5.81e-03
Signaling by NTRKs	91	3.14e-03	1.06e-02	0.21500	0.117000	-0.180000	5.51e-02	3.06e-03
FLT3 Signaling	33	1.20e-01	2.08e-01	0.21500	0.100000	-0.190000	3.19e-01	5.96e-02
Transcriptional Regulation by TP53	307	1.39e-09	2.07e-08	0.21200	0.005970	0.212000	8.59e-01	2.25e-10
Extracellular matrix organization	92	3.32e-03	1.11e-02	0.21200	0.110000	-0.181000	6.94e-02	2.70e-03
Activation of HOX genes during differentiation	43	5.05e-02	1.03e-01	0.21200	0.032100	0.209000	7.16e-01	1.76e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	43	5.05e-02	1.03e-01	0.21200	0.032100	0.209000	7.16e-01	1.76e-02
IKK complex recruitment mediated by RIP1	18	2.65e-01	3.75e-01	0.21200	-0.154000	-0.145000	2.58e-01	2.86e-01
UCH proteinases	76	6.36e-03	1.85e-02	0.21100	-0.009610	0.211000	8.85e-01	1.48e-03
Activation of BAD and translocation to mitochondria	14	3.98e-01	5.16e-01	0.21100	-0.027100	0.210000	8.60e-01	1.75e-01
Downstream TCR signaling	74	7.54e-03	2.11e-02	0.21100	-0.015700	0.211000	8.16e-01	1.77e-03
Centrosome maturation	68	1.19e-02	3.14e-02	0.21100	-0.026800	0.209000	7.03e-01	2.92e-03
Recruitment of mitotic centrosome proteins and complexes	68	1.19e-02	3.14e-02	0.21100	-0.026800	0.209000	7.03e-01	2.92e-03
RAC1 GTPase cycle	117	3.49e-04	1.53e-03	0.21100	-0.032000	-0.208000	5.52e-01	1.06e-04
Methylation	10	4.95e-01	6.09e-01	0.21000	-0.064000	-0.200000	7.26e-01	2.73e-01
Formation of apoptosome	10	5.21e-01	6.29e-01	0.21000	0.208000	-0.028400	2.54e-01	8.76e-01
Regulation of the apoptosome activity	10	5.21e-01	6.29e-01	0.21000	0.208000	-0.028400	2.54e-01	8.76e-01
Generation of second messenger molecules	18	2.76e-01	3.85e-01	0.21000	-0.103000	-0.183000	4.50e-01	1.79e-01
DAP12 interactions	24	2.35e-01	3.42e-01	0.20900	0.117000	-0.173000	3.21e-01	1.43e-01
Ion homeostasis	26	2.02e-01	3.09e-01	0.20900	0.079400	-0.193000	4.84e-01	8.88e-02
PI3K/AKT Signaling in Cancer	53	3.85e-02	8.33e-02	0.20700	0.056500	-0.199000	4.77e-01	1.22e-02
Cell junction organization	28	1.77e-01	2.78e-01	0.20600	0.045200	-0.201000	6.79e-01	6.52e-02
Cellular response to starvation	126	6.56e-04	2.68e-03	0.20600	-0.114000	0.171000	2.72e-02	9.26e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	23	2.06e-01	3.13e-01	0.20600	-0.180000	-0.099300	1.35e-01	4.10e-01
DNA Double Strand Break Response	38	8.01e-02	1.50e-01	0.20500	0.053000	0.199000	5.72e-01	3.44e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling	31	1.55e-01	2.51e-01	0.20500	0.058800	-0.196000	5.72e-01	5.87e-02
Deadenylation of mRNA	23	2.29e-01	3.36e-01	0.20500	0.013500	0.204000	9.11e-01	8.99e-02
Platelet sensitization by LDL	13	4.11e-01	5.25e-01	0.20500	-0.114000	-0.170000	4.78e-01	2.88e-01
Golgi Associated Vesicle Biogenesis	41	6.12e-02	1.22e-01	0.20500	-0.109000	-0.173000	2.29e-01	5.51e-02
Regulation of TP53 Activity through Acetylation	28	1.53e-01	2.49e-01	0.20400	0.189000	0.078400	8.41e-02	4.73e-01
Cargo recognition for clathrin-mediated endocytosis	67	1.65e-02	4.16e-02	0.20400	0.019200	-0.203000	7.86e-01	4.16e-03
Fatty acid metabolism	103	2.20e-03	7.79e-03	0.20200	0.032000	-0.200000	5.75e-01	4.84e-04
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	51	4.62e-02	9.62e-02	0.20200	0.017300	-0.201000	8.31e-01	1.31e-02
MyD88-independent TLR4 cascade	78	1.08e-02	2.91e-02	0.20200	0.058000	-0.193000	3.77e-01	3.25e-03
TRIF(TICAM1)-mediated TLR4 signaling	78	1.08e-02	2.91e-02	0.20200	0.058000	-0.193000	3.77e-01	3.25e-03
VEGFA-VEGFR2 Pathway	72	1.51e-02	3.83e-02	0.20100	0.049900	-0.195000	4.65e-01	4.28e-03
Signaling by Hippo	13	4.80e-01	5.94e-01	0.20100	0.179000	-0.091700	2.65e-01	5.67e-01
Signaling by NTRK1 (TRKA)	83	1.03e-02	2.79e-02	0.20000	0.099800	-0.173000	1.17e-01	6.62e-03
Phase II - Conjugation of compounds	46	5.99e-02	1.20e-01	0.20000	-0.198000	-0.022900	2.01e-02	7.89e-01
Degradation of beta-catenin by the destruction complex	70	1.30e-02	3.39e-02	0.19900	0.044600	0.194000	5.20e-01	4.98e-03
ADP signalling through P2Y purinoceptor 1	15	3.88e-01	5.07e-01	0.19900	-0.065400	-0.188000	6.61e-01	2.07e-01
Biotin transport and metabolism	10	5.80e-01	6.84e-01	0.19900	-0.143000	0.139000	4.34e-01	4.47e-01
Signaling by FGFR4	26	2.40e-01	3.48e-01	0.19900	0.166000	-0.110000	1.43e-01	3.32e-01
HDMs demethylate histones	18	3.77e-01	4.94e-01	0.19900	-0.137000	0.143000	3.13e-01	2.92e-01
Ovarian tumor domain proteases	31	1.37e-01	2.28e-01	0.19900	-0.099600	-0.172000	3.38e-01	9.82e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	4.25e-01	5.40e-01	0.19800	0.044100	-0.193000	7.67e-01	1.95e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	3.61e-01	4.81e-01	0.19700	-0.115000	-0.160000	4.27e-01	2.67e-01
Golgi-to-ER retrograde transport	96	5.45e-03	1.64e-02	0.19700	-0.080900	0.180000	1.72e-01	2.40e-03
RND3 GTPase cycle	30	2.02e-01	3.09e-01	0.19700	0.139000	-0.139000	1.87e-01	1.87e-01
Glyoxylate metabolism and glycine degradation	20	3.14e-01	4.31e-01	0.19700	-0.010000	0.197000	9.38e-01	1.28e-01
Metabolism of fat-soluble vitamins	13	4.99e-01	6.12e-01	0.19700	0.159000	-0.116000	3.22e-01	4.69e-01
Signaling by Receptor Tyrosine Kinases	301	1.45e-07	1.39e-06	0.19600	0.090800	-0.174000	7.23e-03	2.65e-07
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	3.42e-01	4.60e-01	0.19600	0.193000	0.031700	1.56e-01	8.16e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	3.29e-01	4.47e-01	0.19600	-0.082600	-0.177000	5.44e-01	1.93e-01
The citric acid (TCA) cycle and respiratory electron transport	128	7.23e-04	2.90e-03	0.19600	-0.012000	0.195000	8.16e-01	1.44e-04
Signaling by SCF-KIT	33	1.71e-01	2.69e-01	0.19500	0.071900	-0.181000	4.75e-01	7.25e-02
Signaling by EGFR in Cancer	17	3.63e-01	4.81e-01	0.19300	0.183000	0.063200	1.92e-01	6.52e-01
Citric acid cycle (TCA cycle)	20	2.94e-01	4.07e-01	0.19300	0.152000	0.119000	2.40e-01	3.55e-01
Translation of Structural Proteins	27	1.93e-01	2.96e-01	0.19300	-0.113000	-0.156000	3.08e-01	1.60e-01
Activation of kainate receptors upon glutamate binding	16	3.91e-01	5.10e-01	0.19300	-0.049600	-0.186000	7.31e-01	1.97e-01
RNA Polymerase III Abortive And Retractive Initiation	39	1.26e-01	2.13e-01	0.19300	-0.057200	0.184000	5.37e-01	4.69e-02
RNA Polymerase III Transcription	39	1.26e-01	2.13e-01	0.19300	-0.057200	0.184000	5.37e-01	4.69e-02
Signaling by ERBB2 KD Mutants	13	4.86e-01	5.99e-01	0.19300	0.192000	-0.012000	2.30e-01	9.40e-01
G beta:gamma signalling through PLC beta	12	5.04e-01	6.15e-01	0.19300	-0.019000	-0.192000	9.09e-01	2.50e-01
Presynaptic function of Kainate receptors	12	5.04e-01	6.15e-01	0.19300	-0.019000	-0.192000	9.09e-01	2.50e-01
Depolymerisation of the Nuclear Lamina	14	4.33e-01	5.49e-01	0.19200	0.171000	0.087500	2.68e-01	5.71e-01
Innate Immune System	636	1.88e-15	7.46e-14	0.19200	-0.020600	-0.191000	3.84e-01	6.61e-16
Transcriptional regulation by RUNX2	86	8.23e-03	2.29e-02	0.19200	0.010500	0.192000	8.66e-01	2.17e-03
Signaling by MET	43	1.14e-01	2.00e-01	0.19200	0.122000	-0.148000	1.67e-01	9.38e-02
Regulation of signaling by CBL	14	4.92e-01	6.05e-01	0.19200	0.114000	-0.154000	4.60e-01	3.19e-01
Potential therapeutics for SARS	67	1.90e-02	4.76e-02	0.19100	0.159000	0.105000	2.42e-02	1.39e-01
Clathrin-mediated endocytosis	93	6.31e-03	1.85e-02	0.19100	-0.000753	-0.191000	9.90e-01	1.53e-03
Zinc transporters	12	5.46e-01	6.52e-01	0.19100	-0.100000	0.162000	5.48e-01	3.31e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	37	1.18e-01	2.05e-01	0.19000	0.066800	0.178000	4.82e-01	6.12e-02
Striated Muscle Contraction	10	6.08e-01	7.06e-01	0.19000	0.116000	-0.151000	5.27e-01	4.10e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	24	2.66e-01	3.75e-01	0.18900	-0.187000	-0.027500	1.14e-01	8.16e-01
Heme biosynthesis	10	6.09e-01	7.07e-01	0.18900	-0.094900	0.163000	6.03e-01	3.72e-01
Intrinsic Pathway for Apoptosis	48	6.25e-02	1.24e-01	0.18800	0.109000	0.153000	1.92e-01	6.65e-02
Regulation of TP53 Activity through Methylation	17	3.79e-01	4.96e-01	0.18700	0.111000	0.150000	4.28e-01	2.84e-01
RAB GEFs exchange GTP for GDP on RABs	65	3.54e-02	7.77e-02	0.18600	0.014100	-0.186000	8.44e-01	9.74e-03
Regulation of actin dynamics for phagocytic cup formation	47	1.03e-01	1.84e-01	0.18600	0.083100	-0.167000	3.25e-01	4.85e-02
Hedgehog ‘on’ state	64	3.17e-02	7.13e-02	0.18600	0.046000	0.180000	5.26e-01	1.30e-02
AKT phosphorylates targets in the cytosol	13	5.38e-01	6.45e-01	0.18500	0.097400	-0.158000	5.43e-01	3.25e-01
Metabolism of lipids	450	1.57e-10	3.02e-09	0.18500	-0.012100	-0.185000	6.65e-01	3.15e-11
Endosomal Sorting Complex Required For Transport (ESCRT)	27	2.47e-01	3.55e-01	0.18400	-0.011500	-0.184000	9.18e-01	9.85e-02
Ephrin signaling	13	5.33e-01	6.40e-01	0.18400	0.174000	-0.059800	2.77e-01	7.09e-01
Activation of G protein gated Potassium channels	11	5.60e-01	6.67e-01	0.18400	-0.030100	-0.182000	8.63e-01	2.97e-01
G protein gated Potassium channels	11	5.60e-01	6.67e-01	0.18400	-0.030100	-0.182000	8.63e-01	2.97e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	11	5.60e-01	6.67e-01	0.18400	-0.030100	-0.182000	8.63e-01	2.97e-01
Neddylation	188	1.30e-04	6.45e-04	0.18400	-0.058300	0.175000	1.70e-01	3.98e-05
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	30	2.44e-01	3.53e-01	0.18300	-0.082000	0.164000	4.37e-01	1.20e-01
Gene expression (Transcription)	1050	4.77e-23	4.50e-21	0.18300	0.087100	0.161000	3.81e-06	1.10e-17
Synthesis of bile acids and bile salts	13	5.11e-01	6.20e-01	0.18300	-0.022100	-0.182000	8.90e-01	2.57e-01
Inwardly rectifying K+ channels	12	5.18e-01	6.28e-01	0.18300	-0.109000	-0.147000	5.15e-01	3.78e-01
Assembly and cell surface presentation of NMDA receptors	13	5.02e-01	6.14e-01	0.18200	0.172000	0.061100	2.84e-01	7.03e-01
Hemostasis	312	2.94e-07	2.62e-06	0.18200	0.009980	-0.182000	7.64e-01	4.23e-08
Signaling by VEGF	74	2.96e-02	6.74e-02	0.18200	0.046200	-0.176000	4.92e-01	8.95e-03
Regulation of TP53 Expression and Degradation	34	1.98e-01	3.03e-01	0.18200	-0.046900	0.176000	6.36e-01	7.64e-02
Death Receptor Signalling	103	6.79e-03	1.95e-02	0.18100	0.012800	-0.181000	8.23e-01	1.58e-03
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	4.75e-01	5.89e-01	0.18100	0.159000	0.086900	3.04e-01	5.73e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	4.11e-01	5.25e-01	0.18100	-0.000852	0.181000	9.95e-01	1.84e-01
SARS-CoV-2-host interactions	153	9.82e-04	3.71e-03	0.18100	-0.075700	0.164000	1.08e-01	4.90e-04
Signaling by ALK	19	3.63e-01	4.81e-01	0.18000	0.111000	0.142000	4.00e-01	2.85e-01
ER Quality Control Compartment (ERQC)	18	3.88e-01	5.08e-01	0.18000	-0.078200	-0.163000	5.66e-01	2.33e-01
Association of TriC/CCT with target proteins during biosynthesis	30	2.24e-01	3.31e-01	0.18000	0.018000	0.179000	8.65e-01	8.93e-02
BBSome-mediated cargo-targeting to cilium	19	3.64e-01	4.81e-01	0.18000	-0.128000	-0.126000	3.33e-01	3.41e-01
Gap junction trafficking	10	5.92e-01	6.94e-01	0.18000	0.158000	0.086000	3.88e-01	6.38e-01
Circadian Clock	50	1.11e-01	1.97e-01	0.17900	0.136000	-0.116000	9.66e-02	1.55e-01
RHO GTPase cycle	309	7.18e-07	5.76e-06	0.17900	0.021700	-0.177000	5.15e-01	1.06e-07
TGF-beta receptor signaling activates SMADs	39	1.82e-01	2.83e-01	0.17900	0.123000	-0.129000	1.83e-01	1.63e-01
RND1 GTPase cycle	30	2.66e-01	3.75e-01	0.17800	0.153000	-0.092200	1.48e-01	3.82e-01
SUMOylation of transcription cofactors	34	1.96e-01	3.01e-01	0.17700	0.177000	0.008070	7.38e-02	9.35e-01
Ca2+ pathway	39	1.58e-01	2.54e-01	0.17700	-0.003800	-0.177000	9.67e-01	5.61e-02
NR1H2 and NR1H3-mediated signaling	27	2.51e-01	3.57e-01	0.17700	-0.137000	-0.112000	2.18e-01	3.16e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	42	1.68e-01	2.65e-01	0.17600	0.126000	-0.123000	1.58e-01	1.68e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	42	1.68e-01	2.65e-01	0.17600	0.126000	-0.123000	1.58e-01	1.68e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	42	1.68e-01	2.65e-01	0.17600	0.126000	-0.123000	1.58e-01	1.68e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	42	1.68e-01	2.65e-01	0.17600	0.126000	-0.123000	1.58e-01	1.68e-01
Signaling by NOTCH1 in Cancer	42	1.68e-01	2.65e-01	0.17600	0.126000	-0.123000	1.58e-01	1.68e-01
Signaling by Activin	12	5.99e-01	6.99e-01	0.17600	0.105000	-0.141000	5.28e-01	3.98e-01
Metabolism of cofactors	17	4.82e-01	5.96e-01	0.17600	-0.096800	0.147000	4.90e-01	2.95e-01
Inflammasomes	16	4.47e-01	5.61e-01	0.17600	-0.094300	-0.148000	5.14e-01	3.05e-01
Defects in vitamin and cofactor metabolism	16	4.79e-01	5.93e-01	0.17500	-0.175000	0.003650	2.26e-01	9.80e-01
RHOJ GTPase cycle	38	1.80e-01	2.81e-01	0.17500	0.019500	-0.174000	8.36e-01	6.40e-02
The NLRP3 inflammasome	12	5.80e-01	6.84e-01	0.17500	0.014800	-0.174000	9.29e-01	2.97e-01
Apoptotic execution phase	34	2.13e-01	3.21e-01	0.17500	0.174000	-0.010000	7.88e-02	9.20e-01
Regulation of innate immune responses to cytosolic DNA	12	5.64e-01	6.70e-01	0.17500	-0.037600	-0.170000	8.22e-01	3.07e-01
Diseases associated with O-glycosylation of proteins	21	4.11e-01	5.25e-01	0.17400	0.082500	-0.153000	5.13e-01	2.24e-01
Signaling by FGFR2	49	8.82e-02	1.64e-01	0.17400	0.125000	0.121000	1.31e-01	1.43e-01
Glutathione conjugation	21	4.09e-01	5.25e-01	0.17200	-0.165000	0.050900	1.91e-01	6.87e-01
Oncogene Induced Senescence	30	2.39e-01	3.47e-01	0.17100	0.089600	0.146000	3.96e-01	1.67e-01
RNA Polymerase II Transcription	937	1.80e-18	1.01e-16	0.17100	0.110000	0.131000	2.87e-08	4.14e-11
Interleukin-12 signaling	37	2.28e-01	3.35e-01	0.17100	-0.109000	0.131000	2.49e-01	1.69e-01
Non-integrin membrane-ECM interactions	14	5.56e-01	6.64e-01	0.17100	0.045500	-0.164000	7.68e-01	2.87e-01
Cargo trafficking to the periciliary membrane	41	1.42e-01	2.35e-01	0.17000	-0.117000	-0.124000	1.97e-01	1.70e-01
Negative regulation of the PI3K/AKT network	57	8.68e-02	1.62e-01	0.17000	0.007420	-0.169000	9.23e-01	2.72e-02
Transport of bile salts and organic acids, metal ions and amine compounds	34	2.10e-01	3.18e-01	0.16900	-0.068700	-0.154000	4.88e-01	1.20e-01
Downregulation of TGF-beta receptor signaling	26	3.62e-01	4.81e-01	0.16900	0.124000	-0.114000	2.72e-01	3.16e-01
Regulation of TP53 Degradation	33	2.66e-01	3.75e-01	0.16900	-0.063400	0.156000	5.29e-01	1.21e-01
Downstream signaling of activated FGFR1	13	5.45e-01	6.52e-01	0.16800	0.119000	0.119000	4.58e-01	4.57e-01
Downstream signaling of activated FGFR2	13	5.45e-01	6.52e-01	0.16800	0.119000	0.119000	4.58e-01	4.57e-01
Downstream signaling of activated FGFR3	13	5.45e-01	6.52e-01	0.16800	0.119000	0.119000	4.58e-01	4.57e-01
Downstream signaling of activated FGFR4	13	5.45e-01	6.52e-01	0.16800	0.119000	0.119000	4.58e-01	4.57e-01
NOD1/2 Signaling Pathway	25	3.72e-01	4.90e-01	0.16800	0.076100	-0.150000	5.10e-01	1.95e-01
Synthesis of PA	18	4.74e-01	5.89e-01	0.16700	0.010900	-0.166000	9.36e-01	2.22e-01
EPH-Ephrin signaling	58	9.48e-02	1.73e-01	0.16600	0.165000	-0.024400	3.02e-02	7.49e-01
Negative regulation of MAPK pathway	38	2.19e-01	3.26e-01	0.16600	0.036100	-0.162000	7.00e-01	8.40e-02
Triglyceride catabolism	12	6.34e-01	7.27e-01	0.16600	0.138000	-0.091800	4.08e-01	5.82e-01
Apoptosis	137	2.78e-03	9.46e-03	0.16500	0.059700	0.154000	2.29e-01	1.98e-03
VEGFR2 mediated vascular permeability	22	4.16e-01	5.30e-01	0.16500	-0.163000	0.024300	1.86e-01	8.44e-01
TNFs bind their physiological receptors	10	6.62e-01	7.49e-01	0.16400	0.016200	0.163000	9.29e-01	3.72e-01
L1CAM interactions	45	1.92e-01	2.96e-01	0.16300	0.104000	-0.126000	2.27e-01	1.44e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	6.17e-01	7.12e-01	0.16300	-0.125000	-0.105000	4.72e-01	5.46e-01
Constitutive Signaling by AKT1 E17K in Cancer	24	3.73e-01	4.90e-01	0.16300	-0.019200	-0.162000	8.71e-01	1.69e-01
RHOF GTPase cycle	27	3.73e-01	4.90e-01	0.16300	0.099000	-0.129000	3.73e-01	2.45e-01
SARS-CoV-1 Infection	46	1.47e-01	2.41e-01	0.16300	-0.043100	-0.157000	6.13e-01	6.61e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	6.45e-01	7.32e-01	0.16200	0.135000	-0.089800	4.17e-01	5.90e-01
Trafficking of AMPA receptors	12	6.45e-01	7.32e-01	0.16200	0.135000	-0.089800	4.17e-01	5.90e-01
FOXO-mediated transcription	47	1.78e-01	2.79e-01	0.16200	0.143000	-0.076900	9.04e-02	3.62e-01
Transmission across Chemical Synapses	103	2.23e-02	5.36e-02	0.16200	0.052700	-0.153000	3.56e-01	7.55e-03
Generic Transcription Pathway	840	4.31e-15	1.65e-13	0.16200	0.124000	0.103000	2.41e-09	7.00e-07
Cellular response to chemical stress	148	3.92e-03	1.28e-02	0.16100	-0.026000	0.159000	5.87e-01	9.00e-04
Sensory processing of sound by outer hair cells of the cochlea	19	4.96e-01	6.10e-01	0.16000	0.038700	-0.155000	7.70e-01	2.43e-01
FCERI mediated MAPK activation	25	3.52e-01	4.71e-01	0.16000	-0.126000	-0.098200	2.76e-01	3.96e-01
Interleukin-12 family signaling	43	2.22e-01	3.29e-01	0.16000	-0.125000	0.098600	1.55e-01	2.64e-01
Cell-cell junction organization	13	5.97e-01	6.98e-01	0.15900	-0.157000	-0.028400	3.27e-01	8.59e-01
Peptide hormone metabolism	30	3.26e-01	4.43e-01	0.15900	0.019700	-0.158000	8.52e-01	1.34e-01
Signaling by NOTCH4	69	7.64e-02	1.46e-01	0.15900	-0.018800	0.158000	7.88e-01	2.34e-02
Heme signaling	26	4.05e-01	5.21e-01	0.15900	0.094600	-0.127000	4.04e-01	2.61e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	5.87e-01	6.88e-01	0.15900	0.062900	-0.146000	6.73e-01	3.29e-01
NF-kB is activated and signals survival	10	7.01e-01	7.78e-01	0.15800	0.059300	-0.147000	7.46e-01	4.22e-01
Biological oxidations	79	3.99e-02	8.58e-02	0.15800	-0.094800	-0.127000	1.46e-01	5.21e-02
Post-chaperonin tubulin folding pathway	12	6.23e-01	7.18e-01	0.15800	0.044000	0.152000	7.92e-01	3.63e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	6.83e-01	7.65e-01	0.15800	0.079200	-0.136000	6.49e-01	4.34e-01
TCF dependent signaling in response to WNT	122	7.82e-03	2.18e-02	0.15700	0.079700	0.135000	1.30e-01	1.00e-02
p75NTR signals via NF-kB	12	6.36e-01	7.28e-01	0.15700	-0.010300	-0.157000	9.51e-01	3.47e-01
Signaling by Insulin receptor	44	2.07e-01	3.14e-01	0.15700	0.028900	-0.154000	7.41e-01	7.74e-02
Cellular responses to stress	557	8.59e-09	1.02e-07	0.15700	-0.044500	0.150000	7.75e-02	2.41e-09
Signaling by FGFR3 in disease	10	6.82e-01	7.65e-01	0.15600	0.036300	0.152000	8.43e-01	4.06e-01
E3 ubiquitin ligases ubiquitinate target proteins	42	2.46e-01	3.54e-01	0.15600	-0.123000	0.094800	1.67e-01	2.88e-01
TRAF3-dependent IRF activation pathway	14	5.87e-01	6.88e-01	0.15600	-0.151000	-0.038500	3.29e-01	8.03e-01
Retinoid metabolism and transport	11	6.94e-01	7.74e-01	0.15500	0.105000	-0.114000	5.46e-01	5.12e-01
Interleukin-2 signaling	10	6.89e-01	7.69e-01	0.15500	-0.020300	-0.154000	9.12e-01	4.00e-01
Estrogen-dependent gene expression	73	7.71e-02	1.47e-01	0.15500	-0.017800	0.154000	7.93e-01	2.36e-02
Signaling by FLT3 fusion proteins	17	5.72e-01	6.76e-01	0.15400	0.122000	-0.094400	3.83e-01	5.00e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	48	1.56e-01	2.53e-01	0.15400	-0.085300	-0.128000	3.07e-01	1.25e-01
Cellular responses to stimuli	562	1.37e-08	1.60e-07	0.15400	-0.043100	0.148000	8.53e-02	3.70e-09
RAC3 GTPase cycle	59	1.09e-01	1.94e-01	0.15400	-0.051200	-0.145000	4.97e-01	5.41e-02
O-linked glycosylation	41	2.58e-01	3.66e-01	0.15300	0.059000	-0.141000	5.14e-01	1.18e-01
ADP signalling through P2Y purinoceptor 12	12	6.48e-01	7.35e-01	0.15200	-0.033400	-0.148000	8.41e-01	3.75e-01
Signaling by FGFR3	27	4.25e-01	5.40e-01	0.15200	0.123000	-0.088700	2.69e-01	4.26e-01
GPCR ligand binding	69	1.13e-01	2.00e-01	0.15100	0.127000	-0.081800	6.82e-02	2.41e-01
Sensory processing of sound	29	4.01e-01	5.18e-01	0.15100	0.080700	-0.127000	4.52e-01	2.35e-01
Sensory processing of sound by inner hair cells of the cochlea	29	4.01e-01	5.18e-01	0.15100	0.080700	-0.127000	4.52e-01	2.35e-01
G beta:gamma signalling through CDC42	13	6.35e-01	7.28e-01	0.15100	-0.016600	-0.150000	9.17e-01	3.50e-01
Mitophagy	25	3.95e-01	5.13e-01	0.15000	0.101000	0.112000	3.83e-01	3.34e-01
Anchoring of the basal body to the plasma membrane	80	7.86e-02	1.48e-01	0.15000	-0.057500	0.139000	3.75e-01	3.20e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	4.34e-01	5.49e-01	0.15000	0.092300	-0.118000	4.07e-01	2.89e-01
Tie2 Signaling	10	7.07e-01	7.83e-01	0.15000	0.020400	0.148000	9.11e-01	4.16e-01
Regulated Necrosis	45	2.20e-01	3.27e-01	0.15000	0.001040	-0.150000	9.90e-01	8.30e-02
Intra-Golgi traffic	38	2.59e-01	3.67e-01	0.15000	-0.141000	-0.050300	1.33e-01	5.92e-01
Post-translational modification: synthesis of GPI-anchored proteins	31	3.47e-01	4.65e-01	0.14900	0.148000	0.015400	1.53e-01	8.83e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	6.43e-01	7.32e-01	0.14900	0.149000	0.010900	3.54e-01	9.46e-01
Glycosaminoglycan metabolism	65	1.21e-01	2.08e-01	0.14800	0.011700	-0.148000	8.71e-01	3.98e-02
PTEN Regulation	118	2.07e-02	5.09e-02	0.14800	0.001890	0.148000	9.72e-01	5.60e-03
NRAGE signals death through JNK	35	3.10e-01	4.26e-01	0.14800	-0.010400	-0.148000	9.15e-01	1.31e-01
Chaperone Mediated Autophagy	14	6.44e-01	7.32e-01	0.14800	0.141000	-0.044500	3.61e-01	7.73e-01
Mitochondrial biogenesis	55	1.92e-01	2.96e-01	0.14800	-0.095100	0.113000	2.23e-01	1.47e-01
Signaling by FGFR	53	1.51e-01	2.46e-01	0.14800	0.119000	0.087800	1.35e-01	2.70e-01
Regulation of beta-cell development	16	6.13e-01	7.10e-01	0.14800	0.134000	-0.061900	3.54e-01	6.68e-01
Cell surface interactions at the vascular wall	57	1.37e-01	2.27e-01	0.14700	-0.063400	-0.133000	4.09e-01	8.28e-02
Signaling by ALK fusions and activated point mutants	49	2.28e-01	3.35e-01	0.14700	0.071000	-0.129000	3.90e-01	1.19e-01
Signaling by ALK in cancer	49	2.28e-01	3.35e-01	0.14700	0.071000	-0.129000	3.90e-01	1.19e-01
SLC-mediated transmembrane transport	111	2.01e-02	4.99e-02	0.14700	-0.093600	-0.113000	8.92e-02	3.96e-02
TP53 Regulates Transcription of Cell Death Genes	31	3.99e-01	5.16e-01	0.14700	0.114000	-0.092900	2.73e-01	3.71e-01
Chondroitin sulfate/dermatan sulfate metabolism	28	3.95e-01	5.13e-01	0.14600	-0.026100	-0.144000	8.12e-01	1.88e-01
Processing of SMDT1	12	6.93e-01	7.73e-01	0.14600	-0.043600	0.139000	7.94e-01	4.04e-01
Synthesis of substrates in N-glycan biosythesis	48	2.47e-01	3.55e-01	0.14600	0.093500	-0.112000	2.63e-01	1.81e-01
mTORC1-mediated signalling	23	4.92e-01	6.05e-01	0.14500	-0.143000	0.027900	2.36e-01	8.17e-01
RAS processing	16	6.28e-01	7.23e-01	0.14500	-0.104000	0.101000	4.69e-01	4.84e-01
N-Glycan antennae elongation	11	7.28e-01	8.00e-01	0.14500	-0.089900	0.113000	6.05e-01	5.15e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	7.13e-01	7.87e-01	0.14400	-0.124000	-0.072900	4.96e-01	6.90e-01
NOTCH3 Intracellular Domain Regulates Transcription	15	6.14e-01	7.10e-01	0.14400	-0.037800	-0.138000	8.00e-01	3.53e-01
RHOQ GTPase cycle	40	3.04e-01	4.19e-01	0.14300	0.025900	-0.141000	7.77e-01	1.24e-01
Signaling by NOTCH3	30	4.03e-01	5.20e-01	0.14300	0.012500	-0.142000	9.05e-01	1.78e-01
p75 NTR receptor-mediated signalling	65	1.43e-01	2.35e-01	0.14300	0.016000	-0.142000	8.24e-01	4.86e-02
Long-term potentiation	11	6.96e-01	7.75e-01	0.14300	0.127000	0.064900	4.66e-01	7.10e-01
Mitochondrial calcium ion transport	18	6.05e-01	7.04e-01	0.14200	-0.111000	0.089700	4.16e-01	5.10e-01
RHO GTPase Effectors	190	3.72e-03	1.22e-02	0.14200	-0.014700	0.141000	7.28e-01	8.23e-04
Cell death signalling via NRAGE, NRIF and NADE	50	2.16e-01	3.23e-01	0.14200	-0.012300	-0.141000	8.81e-01	8.46e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	44	2.84e-01	3.96e-01	0.14000	-0.019400	0.138000	8.24e-01	1.13e-01
RNA Polymerase III Transcription Termination	21	5.31e-01	6.38e-01	0.13900	0.025900	0.137000	8.37e-01	2.78e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	62	1.88e-01	2.91e-01	0.13900	0.123000	-0.066000	9.57e-02	3.70e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	7.17e-01	7.91e-01	0.13900	0.032000	0.135000	8.54e-01	4.38e-01
Immune System	1180	2.47e-14	8.20e-13	0.13800	-0.031400	-0.135000	7.95e-02	5.08e-14
TCR signaling	92	9.02e-02	1.66e-01	0.13800	-0.082900	0.111000	1.70e-01	6.76e-02
RAF activation	29	4.51e-01	5.66e-01	0.13800	0.031500	-0.134000	7.69e-01	2.12e-01
Uptake and actions of bacterial toxins	19	6.07e-01	7.05e-01	0.13800	0.070500	-0.118000	5.95e-01	3.73e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	40	3.37e-01	4.55e-01	0.13700	0.025600	-0.134000	7.79e-01	1.42e-01
Prostacyclin signalling through prostacyclin receptor	11	7.30e-01	8.02e-01	0.13600	-0.015600	-0.135000	9.29e-01	4.37e-01
Inactivation of CSF3 (G-CSF) signaling	19	5.85e-01	6.88e-01	0.13600	-0.012800	-0.135000	9.23e-01	3.09e-01
Metabolism of proteins	1259	1.52e-13	4.35e-12	0.13600	-0.026600	0.133000	1.27e-01	2.24e-14
Signal amplification	19	5.84e-01	6.87e-01	0.13500	-0.016800	-0.134000	8.99e-01	3.11e-01
Transcriptional regulation by RUNX3	76	1.12e-01	1.99e-01	0.13400	0.065700	0.116000	3.23e-01	8.05e-02
Cholesterol biosynthesis	24	5.23e-01	6.31e-01	0.13300	-0.012700	-0.132000	9.14e-01	2.63e-01
CTLA4 inhibitory signaling	16	6.74e-01	7.59e-01	0.13200	0.120000	-0.055400	4.05e-01	7.01e-01
Neurotransmitter receptors and postsynaptic signal transmission	79	1.40e-01	2.32e-01	0.13100	0.027100	-0.128000	6.78e-01	4.92e-02
ATF6 (ATF6-alpha) activates chaperones	10	7.56e-01	8.22e-01	0.13100	0.115000	0.062700	5.28e-01	7.32e-01
Transcriptional regulation by RUNX1	135	3.25e-02	7.22e-02	0.13100	-0.001030	0.131000	9.84e-01	9.08e-03
Interleukin-1 signaling	82	1.17e-01	2.04e-01	0.13000	0.018800	0.129000	7.69e-01	4.40e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses	89	1.28e-01	2.16e-01	0.13000	-0.086300	0.097200	1.60e-01	1.14e-01
EPH-ephrin mediated repulsion of cells	28	4.70e-01	5.86e-01	0.12900	0.117000	0.054400	2.83e-01	6.19e-01
DAP12 signaling	22	5.95e-01	6.95e-01	0.12900	0.044600	-0.121000	7.17e-01	3.26e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	2.96e-01	4.09e-01	0.12800	-0.096500	-0.084800	2.63e-01	3.26e-01
p75NTR recruits signalling complexes	10	7.64e-01	8.27e-01	0.12800	-0.082900	-0.097300	6.50e-01	5.94e-01
Signaling by Interleukins	272	1.76e-03	6.31e-03	0.12800	0.020500	-0.126000	5.64e-01	3.83e-04
RORA activates gene expression	11	7.81e-01	8.38e-01	0.12800	-0.075400	0.103000	6.65e-01	5.54e-01
Pre-NOTCH Processing in Golgi	16	6.85e-01	7.67e-01	0.12800	0.028900	-0.124000	8.41e-01	3.90e-01
Keratan sulfate biosynthesis	14	7.00e-01	7.78e-01	0.12700	0.124000	0.029000	4.22e-01	8.51e-01
CD209 (DC-SIGN) signaling	15	6.74e-01	7.59e-01	0.12700	-0.102000	-0.075400	4.94e-01	6.13e-01
Neurexins and neuroligins	21	5.77e-01	6.82e-01	0.12600	0.090000	0.088600	4.75e-01	4.83e-01
NOTCH1 Intracellular Domain Regulates Transcription	38	4.41e-01	5.56e-01	0.12500	0.096100	-0.080300	3.06e-01	3.92e-01
Sensory Perception	69	2.23e-01	3.29e-01	0.12500	0.111000	-0.057400	1.11e-01	4.11e-01
Interleukin receptor SHC signaling	17	6.67e-01	7.54e-01	0.12500	-0.010300	-0.124000	9.42e-01	3.75e-01
Amyloid fiber formation	28	5.08e-01	6.19e-01	0.12400	-0.028500	-0.121000	7.94e-01	2.68e-01
Regulation of BACH1 activity	11	7.93e-01	8.50e-01	0.12400	0.082800	-0.092000	6.34e-01	5.97e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	32	4.68e-01	5.83e-01	0.12300	0.120000	0.026500	2.39e-01	7.95e-01
ER-Phagosome pathway	71	2.11e-01	3.19e-01	0.12200	-0.017900	0.121000	7.95e-01	7.84e-02
Regulation of RUNX1 Expression and Activity	15	7.05e-01	7.82e-01	0.12200	-0.030400	-0.118000	8.38e-01	4.30e-01
Bile acid and bile salt metabolism	15	7.01e-01	7.78e-01	0.12100	-0.107000	-0.056400	4.73e-01	7.06e-01
MTOR signalling	38	4.04e-01	5.21e-01	0.12100	-0.069100	-0.099100	4.62e-01	2.91e-01
SARS-CoV-2 Infection	219	1.33e-02	3.46e-02	0.12100	-0.067700	0.099800	8.60e-02	1.14e-02
Visual phototransduction	34	4.57e-01	5.71e-01	0.12000	0.109000	0.050000	2.73e-01	6.14e-01
IGF1R signaling cascade	24	5.71e-01	6.76e-01	0.11900	0.093500	0.074200	4.28e-01	5.29e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	24	5.71e-01	6.76e-01	0.11900	0.093500	0.074200	4.28e-01	5.29e-01
RHOH GTPase cycle	29	5.13e-01	6.22e-01	0.11900	-0.061700	-0.102000	5.65e-01	3.44e-01
Cargo concentration in the ER	20	6.81e-01	7.63e-01	0.11800	-0.081900	0.085400	5.26e-01	5.09e-01
activated TAK1 mediates p38 MAPK activation	15	7.10e-01	7.85e-01	0.11800	-0.062100	-0.101000	6.77e-01	5.00e-01
Chromatin modifying enzymes	166	2.37e-02	5.59e-02	0.11800	0.068300	0.096500	1.31e-01	3.27e-02
Chromatin organization	166	2.37e-02	5.59e-02	0.11800	0.068300	0.096500	1.31e-01	3.27e-02
Signaling by Retinoic Acid	19	6.69e-01	7.55e-01	0.11800	0.118000	0.003170	3.73e-01	9.81e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	17	6.79e-01	7.62e-01	0.11800	-0.067300	-0.097000	6.31e-01	4.89e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	16	7.35e-01	8.06e-01	0.11800	0.068300	-0.096200	6.36e-01	5.06e-01
Protein-protein interactions at synapses	33	5.02e-01	6.14e-01	0.11800	-0.002390	0.118000	9.81e-01	2.42e-01
Metalloprotease DUBs	19	6.89e-01	7.69e-01	0.11700	-0.112000	0.035700	4.00e-01	7.88e-01
DNA Damage Recognition in GG-NER	37	4.52e-01	5.66e-01	0.11700	0.026400	0.114000	7.81e-01	2.30e-01
Antigen processing: Ubiquitination & Proteasome degradation	244	9.41e-03	2.57e-02	0.11700	-0.037000	0.111000	3.23e-01	3.00e-03
Ub-specific processing proteases	140	7.09e-02	1.37e-01	0.11600	-0.045400	0.107000	3.55e-01	2.92e-02
Unfolded Protein Response (UPR)	76	2.21e-01	3.28e-01	0.11600	-0.009970	0.116000	8.81e-01	8.22e-02
Suppression of phagosomal maturation	12	7.99e-01	8.54e-01	0.11600	-0.103000	0.053400	5.39e-01	7.49e-01
CLEC7A (Dectin-1) signaling	86	2.03e-01	3.10e-01	0.11500	-0.046800	0.105000	4.54e-01	9.27e-02
Metabolism of steroid hormones	13	7.57e-01	8.22e-01	0.11500	-0.049600	-0.104000	7.57e-01	5.17e-01
Signalling to ERKs	26	5.84e-01	6.87e-01	0.11500	-0.031100	-0.110000	7.84e-01	3.31e-01
N-glycan antennae elongation in the medial/trans-Golgi	18	7.25e-01	7.98e-01	0.11400	-0.092300	0.066400	4.98e-01	6.26e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	14	7.44e-01	8.13e-01	0.11300	0.072100	0.087600	6.40e-01	5.70e-01
Regulation of pyruvate dehydrogenase (PDH) complex	13	7.78e-01	8.38e-01	0.11300	-0.001220	0.113000	9.94e-01	4.80e-01
RHOV GTPase cycle	30	5.79e-01	6.84e-01	0.11200	0.024500	-0.109000	8.16e-01	3.00e-01
RUNX3 regulates p14-ARF	10	8.29e-01	8.77e-01	0.11000	0.110000	0.010200	5.47e-01	9.56e-01
RHO GTPases activate PKNs	26	5.95e-01	6.95e-01	0.11000	0.085400	0.069900	4.51e-01	5.37e-01
Signaling by CSF3 (G-CSF)	24	6.44e-01	7.32e-01	0.11000	-0.004830	-0.110000	9.67e-01	3.52e-01
VLDLR internalisation and degradation	12	8.03e-01	8.57e-01	0.10900	0.109000	0.008800	5.14e-01	9.58e-01
RAC2 GTPase cycle	59	3.42e-01	4.60e-01	0.10900	-0.009480	-0.109000	9.00e-01	1.49e-01
Signaling by FGFR1 in disease	26	6.04e-01	7.04e-01	0.10900	-0.054800	-0.094400	6.29e-01	4.05e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	14	7.79e-01	8.38e-01	0.10800	-0.004610	-0.108000	9.76e-01	4.83e-01
Pre-NOTCH Transcription and Translation	28	6.14e-01	7.10e-01	0.10800	-0.108000	0.008990	3.23e-01	9.34e-01
Infectious disease	648	2.71e-05	1.56e-04	0.10800	-0.008240	0.108000	7.26e-01	4.53e-06
Detoxification of Reactive Oxygen Species	23	6.78e-01	7.62e-01	0.10800	-0.106000	0.022400	3.81e-01	8.53e-01
Mitochondrial iron-sulfur cluster biogenesis	12	8.09e-01	8.63e-01	0.10800	0.002750	0.108000	9.87e-01	5.18e-01
SARS-CoV Infections	277	1.02e-02	2.75e-02	0.10700	-0.011700	0.107000	7.40e-01	2.45e-03
Negative regulators of DDX58/IFIH1 signaling	35	5.30e-01	6.38e-01	0.10700	-0.035700	-0.101000	7.15e-01	3.03e-01
PI3K Cascade	19	7.38e-01	8.08e-01	0.10700	0.096600	-0.045400	4.66e-01	7.32e-01
Beta-catenin independent WNT signaling	107	1.46e-01	2.39e-01	0.10700	0.035900	0.100000	5.22e-01	7.34e-02
Purine catabolism	10	8.55e-01	8.93e-01	0.10600	-0.048300	0.094300	7.91e-01	6.06e-01
Interferon Signaling	141	7.77e-02	1.48e-01	0.10600	-0.059700	-0.087500	2.22e-01	7.41e-02
Autophagy	111	1.60e-01	2.56e-01	0.10500	0.001740	-0.105000	9.75e-01	5.60e-02
Nucleotide catabolism	21	7.07e-01	7.83e-01	0.10500	-0.105000	0.001970	4.06e-01	9.88e-01
Signaling by TGFB family members	87	2.75e-01	3.85e-01	0.10400	0.068100	-0.078900	2.73e-01	2.04e-01
Signaling by WNT	181	4.41e-02	9.31e-02	0.10300	0.072400	0.073600	9.46e-02	8.91e-02
Peptide ligand-binding receptors	16	7.80e-01	8.38e-01	0.10300	-0.101000	0.021800	4.85e-01	8.80e-01
Metabolism of water-soluble vitamins and cofactors	82	2.48e-01	3.55e-01	0.10200	-0.087800	-0.052800	1.70e-01	4.09e-01
Ion transport by P-type ATPases	29	6.32e-01	7.26e-01	0.10200	-0.003690	-0.102000	9.73e-01	3.42e-01
Cytokine Signaling in Immune system	433	1.21e-03	4.50e-03	0.10200	-0.019500	-0.100000	4.92e-01	4.25e-04
Neuronal System	141	1.17e-01	2.04e-01	0.10100	0.000120	-0.101000	9.98e-01	3.91e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	159	1.17e-01	2.04e-01	0.09980	-0.069800	0.071300	1.30e-01	1.22e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	18	7.63e-01	8.26e-01	0.09980	-0.099800	0.000682	4.64e-01	9.96e-01
Diseases of signal transduction by growth factor receptors and second messengers	311	1.49e-02	3.80e-02	0.09930	0.037600	-0.091900	2.58e-01	5.74e-03
Membrane Trafficking	454	1.02e-03	3.85e-03	0.09910	-0.043000	-0.089300	1.21e-01	1.29e-03
Activation of NMDA receptors and postsynaptic events	46	5.06e-01	6.16e-01	0.09910	-0.001920	-0.099100	9.82e-01	2.46e-01
Vitamin B5 (pantothenate) metabolism	12	8.33e-01	8.79e-01	0.09890	0.019400	0.097000	9.07e-01	5.61e-01
Response of Mtb to phagocytosis	21	7.57e-01	8.22e-01	0.09820	-0.075700	0.062500	5.48e-01	6.20e-01
Transcriptional Regulation by VENTX	30	6.23e-01	7.18e-01	0.09800	0.066300	0.072200	5.30e-01	4.94e-01
IRAK1 recruits IKK complex	10	8.55e-01	8.93e-01	0.09790	-0.056600	-0.079800	7.57e-01	6.62e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	8.55e-01	8.93e-01	0.09790	-0.056600	-0.079800	7.57e-01	6.62e-01
STING mediated induction of host immune responses	10	8.83e-01	9.15e-01	0.09520	0.062800	-0.071600	7.31e-01	6.95e-01
Signaling by PDGFR in disease	16	8.21e-01	8.70e-01	0.09460	-0.063600	0.070100	6.59e-01	6.28e-01
Glycogen breakdown (glycogenolysis)	10	8.84e-01	9.15e-01	0.09400	-0.082100	0.045800	6.53e-01	8.02e-01
RAB geranylgeranylation	40	6.17e-01	7.12e-01	0.09380	0.072000	-0.060200	4.31e-01	5.11e-01
TP53 Regulates Metabolic Genes	74	4.10e-01	5.25e-01	0.09350	-0.052000	0.077800	4.41e-01	2.48e-01
Branched-chain amino acid catabolism	21	7.55e-01	8.21e-01	0.09330	-0.009970	-0.092800	9.37e-01	4.62e-01
Metal ion SLC transporters	16	7.99e-01	8.54e-01	0.09300	-0.081800	-0.044100	5.71e-01	7.60e-01
Extra-nuclear estrogen signaling	48	5.10e-01	6.20e-01	0.09280	-0.051100	-0.077500	5.41e-01	3.54e-01
Synthesis of glycosylphosphatidylinositol (GPI)	14	8.30e-01	8.78e-01	0.09250	0.091500	0.013500	5.53e-01	9.30e-01
Syndecan interactions	10	8.71e-01	9.06e-01	0.09240	0.081700	0.043100	6.54e-01	8.13e-01
Hedgehog ‘off’ state	77	3.90e-01	5.09e-01	0.09230	-0.023100	0.089400	7.27e-01	1.76e-01
Diseases associated with glycosylation precursor biosynthesis	15	8.14e-01	8.66e-01	0.09220	0.040100	0.083100	7.88e-01	5.78e-01
Signaling by ERBB2 TMD/JMD mutants	11	8.70e-01	9.06e-01	0.09150	0.091500	0.000864	5.99e-01	9.96e-01
Transcriptional activation of mitochondrial biogenesis	39	6.38e-01	7.29e-01	0.09090	-0.041700	0.080700	6.52e-01	3.84e-01
Metabolism of carbohydrates	186	1.26e-01	2.13e-01	0.09070	-0.071000	0.056400	9.65e-02	1.87e-01
Insulin processing	15	8.25e-01	8.73e-01	0.09070	-0.017200	-0.089000	9.08e-01	5.51e-01
Programmed Cell Death	160	1.26e-01	2.13e-01	0.09020	0.040400	0.080700	3.80e-01	7.96e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta	60	4.59e-01	5.73e-01	0.09020	-0.034600	-0.083300	6.43e-01	2.66e-01
Glycogen metabolism	18	8.14e-01	8.66e-01	0.09010	-0.082600	0.036000	5.44e-01	7.91e-01
MECP2 regulates neuronal receptors and channels	10	8.87e-01	9.16e-01	0.08920	0.089200	0.000715	6.25e-01	9.97e-01
Post NMDA receptor activation events	40	6.05e-01	7.04e-01	0.08860	-0.032800	-0.082400	7.20e-01	3.68e-01
Netrin-1 signaling	25	7.66e-01	8.28e-01	0.08790	0.069200	-0.054300	5.50e-01	6.39e-01
Vesicle-mediated transport	462	3.99e-03	1.29e-02	0.08780	-0.042000	-0.077200	1.27e-01	5.04e-03
IRS-related events triggered by IGF1R	23	7.49e-01	8.17e-01	0.08770	0.069700	0.053200	5.63e-01	6.59e-01
Signaling by FGFR in disease	41	6.48e-01	7.34e-01	0.08760	-0.049700	0.072200	5.82e-01	4.24e-01
Signal Transduction	1382	3.23e-06	2.16e-05	0.08640	0.029400	-0.081200	7.97e-02	1.23e-06
Macroautophagy	101	3.06e-01	4.20e-01	0.08620	-0.027600	-0.081700	6.32e-01	1.57e-01
Signaling by TGF-beta Receptor Complex	73	4.73e-01	5.88e-01	0.08620	0.046400	-0.072600	4.94e-01	2.84e-01
Antigen processing-Cross presentation	79	4.27e-01	5.43e-01	0.08550	-0.008200	0.085100	9.00e-01	1.92e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	29	7.10e-01	7.85e-01	0.08520	0.072400	0.044900	5.00e-01	6.76e-01
Class A/1 (Rhodopsin-like receptors)	40	6.51e-01	7.37e-01	0.08410	-0.003880	-0.084000	9.66e-01	3.58e-01
RND2 GTPase cycle	34	7.17e-01	7.91e-01	0.08320	0.031300	-0.077100	7.53e-01	4.37e-01
Voltage gated Potassium channels	13	8.84e-01	9.15e-01	0.08290	-0.064900	0.051600	6.85e-01	7.47e-01
Axon guidance	313	3.94e-02	8.50e-02	0.08260	0.016500	0.080900	6.19e-01	1.47e-02
Protein folding	63	5.24e-01	6.32e-01	0.08180	0.008830	0.081400	9.04e-01	2.65e-01
Pyroptosis	18	8.51e-01	8.92e-01	0.08070	0.062800	-0.050800	6.45e-01	7.09e-01
Diseases associated with N-glycosylation of proteins	19	8.44e-01	8.86e-01	0.08070	0.057700	-0.056400	6.63e-01	6.70e-01
Retrograde transport at the Trans-Golgi-Network	45	6.41e-01	7.31e-01	0.08040	-0.007050	-0.080100	9.35e-01	3.53e-01
Protein localization	128	3.35e-01	4.54e-01	0.07920	-0.050900	0.060700	3.21e-01	2.38e-01
Mitochondrial Fatty Acid Beta-Oxidation	26	7.73e-01	8.35e-01	0.07910	-0.075400	-0.023900	5.06e-01	8.33e-01
Fatty acyl-CoA biosynthesis	23	7.99e-01	8.54e-01	0.07720	-0.063800	-0.043400	5.96e-01	7.19e-01
Potassium Channels	29	7.62e-01	8.26e-01	0.07690	-0.073700	-0.022100	4.93e-01	8.37e-01
Activation of gene expression by SREBF (SREBP)	35	7.32e-01	8.04e-01	0.07640	-0.005790	-0.076100	9.53e-01	4.36e-01
Diseases of glycosylation	70	5.71e-01	6.76e-01	0.07640	0.061100	-0.045800	3.77e-01	5.09e-01
Oxidative Stress Induced Senescence	56	6.29e-01	7.23e-01	0.07610	-0.021700	0.072900	7.79e-01	3.46e-01
C-type lectin receptors (CLRs)	102	4.47e-01	5.61e-01	0.07580	-0.040400	0.064100	4.82e-01	2.65e-01
Signalling to RAS	13	9.02e-01	9.25e-01	0.07570	-0.060800	0.045200	7.04e-01	7.78e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	33	7.45e-01	8.14e-01	0.07470	0.069600	0.027100	4.89e-01	7.88e-01
Senescence-Associated Secretory Phenotype (SASP)	43	6.76e-01	7.61e-01	0.07460	0.047200	0.057800	5.93e-01	5.13e-01
PPARA activates gene expression	84	4.73e-01	5.88e-01	0.07430	-0.037700	-0.064000	5.51e-01	3.12e-01
Diseases associated with glycosaminoglycan metabolism	16	8.75e-01	9.09e-01	0.07410	0.074100	0.000588	6.08e-01	9.97e-01
Signaling by NOTCH	134	3.21e-01	4.38e-01	0.07330	0.025200	0.068800	6.15e-01	1.71e-01
Chaperonin-mediated protein folding	57	6.36e-01	7.28e-01	0.07310	-0.005080	0.073000	9.47e-01	3.42e-01
Metabolism of vitamins and cofactors	111	3.90e-01	5.09e-01	0.07250	-0.062100	-0.037400	2.60e-01	4.98e-01
PINK1-PRKN Mediated Mitophagy	19	8.50e-01	8.92e-01	0.07220	0.048000	0.053900	7.17e-01	6.85e-01
Transport of small molecules	376	5.12e-02	1.05e-01	0.07130	-0.030600	-0.064400	3.14e-01	3.39e-02
Nervous system development	326	9.05e-02	1.67e-01	0.07070	0.003770	0.070600	9.08e-01	3.00e-02
TAK1-dependent IKK and NF-kappa-B activation	20	8.74e-01	9.09e-01	0.06990	0.052100	-0.046600	6.87e-01	7.18e-01
COPI-independent Golgi-to-ER retrograde traffic	29	8.00e-01	8.54e-01	0.06990	-0.067400	-0.018400	5.30e-01	8.64e-01
Cytoprotection by HMOX1	45	7.40e-01	8.10e-01	0.06980	-0.048000	0.050700	5.78e-01	5.56e-01
Diseases of metabolism	128	3.76e-01	4.94e-01	0.06970	-0.022100	-0.066100	6.66e-01	1.98e-01
Signaling by the B Cell Receptor (BCR)	95	5.13e-01	6.22e-01	0.06970	-0.013300	0.068400	8.23e-01	2.51e-01
Calnexin/calreticulin cycle	23	8.38e-01	8.82e-01	0.06940	-0.065600	-0.022700	5.86e-01	8.50e-01
Synthesis of very long-chain fatty acyl-CoAs	13	9.13e-01	9.32e-01	0.06910	0.012500	-0.067900	9.38e-01	6.72e-01
Drug ADME	28	8.19e-01	8.69e-01	0.06890	-0.001400	0.068900	9.90e-01	5.29e-01
Cellular Senescence	108	4.56e-01	5.70e-01	0.06880	0.010300	0.068100	8.54e-01	2.23e-01
CTNNB1 S33 mutants aren’t phosphorylated	14	9.03e-01	9.25e-01	0.06840	-0.012600	-0.067200	9.35e-01	6.63e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	9.03e-01	9.25e-01	0.06840	-0.012600	-0.067200	9.35e-01	6.63e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	9.03e-01	9.25e-01	0.06840	-0.012600	-0.067200	9.35e-01	6.63e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	9.03e-01	9.25e-01	0.06840	-0.012600	-0.067200	9.35e-01	6.63e-01
Signaling by CTNNB1 phospho-site mutants	14	9.03e-01	9.25e-01	0.06840	-0.012600	-0.067200	9.35e-01	6.63e-01
Signaling by GSK3beta mutants	14	9.03e-01	9.25e-01	0.06840	-0.012600	-0.067200	9.35e-01	6.63e-01
Disorders of Developmental Biology	11	9.32e-01	9.44e-01	0.06770	0.034100	-0.058500	8.45e-01	7.37e-01
Disorders of Nervous System Development	11	9.32e-01	9.44e-01	0.06770	0.034100	-0.058500	8.45e-01	7.37e-01
Loss of function of MECP2 in Rett syndrome	11	9.32e-01	9.44e-01	0.06770	0.034100	-0.058500	8.45e-01	7.37e-01
Pervasive developmental disorders	11	9.32e-01	9.44e-01	0.06770	0.034100	-0.058500	8.45e-01	7.37e-01
COPI-mediated anterograde transport	71	6.41e-01	7.31e-01	0.06760	-0.052000	0.043200	4.50e-01	5.30e-01
Fc epsilon receptor (FCERI) signaling	112	4.97e-01	6.10e-01	0.06730	-0.057300	0.035300	2.96e-01	5.20e-01
Infection with Mycobacterium tuberculosis	23	8.53e-01	8.93e-01	0.06720	-0.067100	-0.004230	5.78e-01	9.72e-01
Regulation of MECP2 expression and activity	24	8.38e-01	8.82e-01	0.06700	0.044000	0.050600	7.09e-01	6.68e-01
Aggrephagy	20	8.64e-01	9.01e-01	0.06680	0.040200	0.053400	7.56e-01	6.80e-01
ESR-mediated signaling	117	4.81e-01	5.95e-01	0.06680	-0.024600	0.062100	6.46e-01	2.48e-01
Beta-catenin phosphorylation cascade	16	9.00e-01	9.25e-01	0.06630	0.001580	-0.066300	9.91e-01	6.47e-01
Metabolism of steroids	88	5.65e-01	6.71e-01	0.06590	0.001490	-0.065900	9.81e-01	2.87e-01
Developmental Biology	484	4.58e-02	9.54e-02	0.06470	0.023400	0.060300	3.84e-01	2.52e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	8.17e-01	8.68e-01	0.06430	0.004550	0.064200	9.64e-01	5.30e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	48	7.54e-01	8.21e-01	0.06390	0.015300	-0.062100	8.55e-01	4.58e-01
Deubiquitination	208	3.15e-01	4.31e-01	0.06390	-0.054300	0.033700	1.80e-01	4.05e-01
Transport to the Golgi and subsequent modification	132	4.54e-01	5.68e-01	0.06260	-0.062000	-0.008310	2.20e-01	8.69e-01
Post-translational protein modification	929	7.07e-03	2.01e-02	0.06220	0.002100	0.062200	9.16e-01	1.79e-03
Regulation of lipid metabolism by PPARalpha	86	6.00e-01	7.00e-01	0.06090	-0.026000	-0.055100	6.78e-01	3.79e-01
Class I MHC mediated antigen processing & presentation	294	2.44e-01	3.53e-01	0.05880	-0.019200	0.055600	5.74e-01	1.04e-01
Metabolic disorders of biological oxidation enzymes	14	9.24e-01	9.40e-01	0.05880	0.045700	0.037000	7.67e-01	8.11e-01
IRS-mediated signalling	22	8.96e-01	9.24e-01	0.05540	0.030000	0.046600	8.08e-01	7.06e-01
Selective autophagy	51	7.78e-01	8.38e-01	0.05480	0.044200	0.032500	5.86e-01	6.89e-01
Disease	1124	1.19e-02	3.15e-02	0.05430	-0.000180	0.054300	9.92e-01	3.03e-03
Regulation of PTEN gene transcription	51	7.82e-01	8.39e-01	0.05420	0.037100	0.039500	6.47e-01	6.26e-01
RHOD GTPase cycle	39	8.33e-01	8.79e-01	0.05410	-0.020900	-0.049900	8.22e-01	5.90e-01
Insulin receptor signalling cascade	27	8.82e-01	9.15e-01	0.05340	0.045500	0.027900	6.82e-01	8.02e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	27	8.96e-01	9.24e-01	0.05290	-0.009500	0.052000	9.32e-01	6.40e-01
Heparan sulfate/heparin (HS-GAG) metabolism	23	9.13e-01	9.32e-01	0.05170	0.003890	-0.051500	9.74e-01	6.69e-01
CD28 dependent PI3K/Akt signaling	18	9.30e-01	9.44e-01	0.05070	0.048700	0.014000	7.21e-01	9.18e-01
Organelle biogenesis and maintenance	207	4.83e-01	5.96e-01	0.05020	-0.047100	0.017300	2.45e-01	6.69e-01
COPII-mediated vesicle transport	52	8.20e-01	8.70e-01	0.04980	-0.006470	-0.049400	9.36e-01	5.39e-01
Costimulation by the CD28 family	45	8.36e-01	8.81e-01	0.04930	-0.037100	-0.032400	6.67e-01	7.07e-01
Transcriptional regulation of granulopoiesis	24	9.10e-01	9.30e-01	0.04900	-0.036200	-0.033000	7.59e-01	7.80e-01
Metabolism	1280	2.04e-02	5.04e-02	0.04800	-0.048000	-0.000429	5.48e-03	9.80e-01
Josephin domain DUBs	11	9.63e-01	9.68e-01	0.04780	0.001150	-0.047800	9.95e-01	7.84e-01
ER to Golgi Anterograde Transport	109	6.79e-01	7.62e-01	0.04750	-0.045100	-0.014900	4.17e-01	7.89e-01
Metabolism of porphyrins	15	9.50e-01	9.61e-01	0.04580	-0.036900	-0.027100	8.05e-01	8.56e-01
APC truncation mutants have impaired AXIN binding	13	9.59e-01	9.65e-01	0.04430	-0.035800	-0.026000	8.23e-01	8.71e-01
AXIN missense mutants destabilize the destruction complex	13	9.59e-01	9.65e-01	0.04430	-0.035800	-0.026000	8.23e-01	8.71e-01
Signaling by AMER1 mutants	13	9.59e-01	9.65e-01	0.04430	-0.035800	-0.026000	8.23e-01	8.71e-01
Signaling by APC mutants	13	9.59e-01	9.65e-01	0.04430	-0.035800	-0.026000	8.23e-01	8.71e-01
Signaling by AXIN mutants	13	9.59e-01	9.65e-01	0.04430	-0.035800	-0.026000	8.23e-01	8.71e-01
Truncations of AMER1 destabilize the destruction complex	13	9.59e-01	9.65e-01	0.04430	-0.035800	-0.026000	8.23e-01	8.71e-01
CD28 co-stimulation	27	9.17e-01	9.35e-01	0.04410	0.032800	0.029400	7.68e-01	7.91e-01
RHOG GTPase cycle	51	8.61e-01	8.99e-01	0.04270	-0.017800	-0.038800	8.26e-01	6.32e-01
Signaling by Hedgehog	101	7.54e-01	8.21e-01	0.04140	0.028600	0.030000	6.20e-01	6.04e-01
MAPK family signaling cascades	196	6.33e-01	7.26e-01	0.03910	0.038500	0.006920	3.56e-01	8.68e-01
NCAM signaling for neurite out-growth	25	9.50e-01	9.61e-01	0.03860	0.023000	-0.031000	8.42e-01	7.89e-01
Factors involved in megakaryocyte development and platelet production	88	8.42e-01	8.85e-01	0.03720	0.035000	-0.012600	5.72e-01	8.39e-01
Adaptive Immune System	493	3.52e-01	4.71e-01	0.03710	-0.016900	-0.033000	5.26e-01	2.16e-01
RAF/MAP kinase cascade	165	7.20e-01	7.94e-01	0.03670	0.036700	-0.001650	4.19e-01	9.71e-01
Cytosolic sensors of pathogen-associated DNA	54	9.05e-01	9.26e-01	0.03670	0.028900	-0.022600	7.14e-01	7.74e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	40	9.29e-01	9.44e-01	0.03650	0.017200	-0.032100	8.51e-01	7.25e-01
Signaling by Nuclear Receptors	155	7.78e-01	8.38e-01	0.03450	-0.026900	0.021600	5.66e-01	6.43e-01
Cilium Assembly	152	7.52e-01	8.21e-01	0.03410	-0.029000	-0.017900	5.38e-01	7.04e-01
HATs acetylate histones	66	9.02e-01	9.25e-01	0.03220	0.032200	0.000227	6.51e-01	9.97e-01
Signaling by Rho GTPases	452	5.10e-01	6.20e-01	0.03220	0.000394	-0.032200	9.89e-01	2.47e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	465	5.20e-01	6.29e-01	0.03110	-0.001050	-0.031100	9.69e-01	2.56e-01
Transcriptional regulation of white adipocyte differentiation	58	9.17e-01	9.35e-01	0.03080	-0.030000	-0.007160	6.93e-01	9.25e-01
PIP3 activates AKT signaling	190	7.81e-01	8.38e-01	0.02980	-0.001420	0.029700	9.73e-01	4.82e-01
Interleukin-1 family signaling	102	8.68e-01	9.04e-01	0.02940	0.013800	0.026000	8.09e-01	6.51e-01
MAPK1/MAPK3 signaling	170	8.15e-01	8.66e-01	0.02930	0.027900	-0.008890	5.33e-01	8.42e-01
Transcriptional Regulation by MECP2	33	9.62e-01	9.68e-01	0.02680	0.022100	0.015200	8.27e-01	8.80e-01
XBP1(S) activates chaperone genes	40	9.67e-01	9.71e-01	0.02390	-0.002290	0.023700	9.80e-01	7.95e-01
Intracellular signaling by second messengers	216	8.80e-01	9.14e-01	0.01990	-0.001360	-0.019800	9.73e-01	6.18e-01
Pre-NOTCH Expression and Processing	43	9.77e-01	9.80e-01	0.01880	-0.018500	-0.003350	8.34e-01	9.70e-01
Signal transduction by L1	11	9.98e-01	9.98e-01	0.01250	-0.004950	0.011500	9.77e-01	9.47e-01
IRE1alpha activates chaperones	41	9.93e-01	9.94e-01	0.01130	-0.007990	0.008000	9.30e-01	9.30e-01
Asparagine N-linked glycosylation	229	9.86e-01	9.89e-01	0.00617	0.005790	0.002130	8.81e-01	9.56e-01
MHC class II antigen presentation	72	9.98e-01	9.98e-01	0.00499	-0.002550	0.004290	9.70e-01	9.50e-01

---

Detailed Gene set reports

Unwinding of DNA

Unwinding of DNA

metric	value
setSize	11
pMANOVA	8.5e-08
p.adjustMANOVA	8.42e-07
s.dist	1.02
s.meth	-0.385
s.rna	0.946
p.meth	0.027
p.rna	5.44e-08

Top 20 genes

Gene	meth	rna
GINS4	-4782.5	5306
GINS3	-4219.5	5085
MCM6	-3762.5	5157
MCM5	-4329.5	4324
MCM4	-3274.0	5206
GINS1	-2904.5	5275
MCM3	-2795.5	4970
MCM7	-2720.0	4817
CDC45	-960.5	5318

Click HERE to show all gene set members

All member genes

	meth	rna
CDC45	-960.5	5318
GINS1	-2904.5	5275
GINS3	-4219.5	5085
GINS4	-4782.5	5306
MCM2	674.5	5209
MCM3	-2795.5	4970
MCM4	-3274.0	5206
MCM5	-4329.5	4324
MCM6	-3762.5	5157
MCM7	-2720.0	4817
MCM8	3129.0	5124

---

---

Defective pyroptosis

Defective pyroptosis

metric	value
setSize	12
pMANOVA	1.34e-06
p.adjustMANOVA	9.9e-06
s.dist	0.85
s.meth	0.151
s.rna	0.837
p.meth	0.365
p.rna	5.18e-07

Top 20 genes

Gene	meth	rna
PRIM1	3513.5	4630
DNMT3A	3883.5	3467
POLA1	3226.5	4151
DNMT3B	2593.5	5018
EED	2044.5	4486
RBBP7	1737.5	4286
POLA2	1188.5	4665

Click HERE to show all gene set members

All member genes

	meth	rna
DNMT1	-4537.5	4662
DNMT3A	3883.5	3467
DNMT3B	2593.5	5018
EED	2044.5	4486
EZH2	-4926.5	5229
H2AFX	-2496.5	5036
POLA1	3226.5	4151
POLA2	1188.5	4665
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RBBP4	-1172.0	3704
RBBP7	1737.5	4286

---

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

metric	value
setSize	10
pMANOVA	3.75e-05
p.adjustMANOVA	0.000206
s.dist	0.846
s.meth	-0.289
s.rna	0.795
p.meth	0.114
p.rna	1.34e-05

Top 20 genes

Gene	meth	rna
CCNB1	-5222.5	5266
NCAPG	-3149.0	5216
NCAPD2	-3214.5	5069
SMC4	-2703.5	5024
SMC2	-1986.5	4899
CSNK2A2	-3252.5	1966
CCNB2	-591.5	5269
CDK1	-467.5	5196

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-5222.5	5266
CCNB2	-591.5	5269
CDK1	-467.5	5196
CSNK2A2	-3252.5	1966
CSNK2B	1217.5	104
NCAPD2	-3214.5	5069
NCAPG	-3149.0	5216
NCAPH	496.5	5304
SMC2	-1986.5	4899
SMC4	-2703.5	5024

---

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

metric	value
setSize	31
pMANOVA	4.46e-14
p.adjustMANOVA	1.3e-12
s.dist	0.806
s.meth	0.0469
s.rna	0.804
p.meth	0.652
p.rna	8.75e-15

Top 20 genes

Gene	meth	rna
POLE2	4349.5	5252
PRIM1	3513.5	4630
MCM8	3129.0	5124
POLA1	3226.5	4151
CDC7	2460.5	5155
MCM10	2300.5	5307
GMNN	2262.5	5054
CDC6	1904.5	5328
CDK2	2631.5	3737
POLE3	2378.0	3771
POLE	1888.0	4607
ORC3	2903.5	2076
POLA2	1188.5	4665
MCM2	674.5	5209
ORC4	906.0	186
ORC1	0.5	5223
DBF4	0.5	5161

Click HERE to show all gene set members

All member genes

	meth	rna
CDC45	-960.5	5318
CDC6	1904.5	5328
CDC7	2460.5	5155
CDK2	2631.5	3737
CDT1	-4608.5	5199
DBF4	0.5	5161
GMNN	2262.5	5054
MCM10	2300.5	5307
MCM2	674.5	5209
MCM3	-2795.5	4970
MCM4	-3274.0	5206
MCM5	-4329.5	4324
MCM6	-3762.5	5157
MCM7	-2720.0	4817
MCM8	3129.0	5124
ORC1	0.5	5223
ORC2	-3133.5	3513
ORC3	2903.5	2076
ORC4	906.0	186
ORC5	-2220.5	4434
ORC6	-2966.5	5296
POLA1	3226.5	4151
POLA2	1188.5	4665
POLE	1888.0	4607
POLE2	4349.5	5252
POLE3	2378.0	3771
POLE4	-3816.5	1032
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

DNA strand elongation

DNA strand elongation

metric	value
setSize	30
pMANOVA	8.72e-12
p.adjustMANOVA	2.02e-10
s.dist	0.752
s.meth	-0.0299
s.rna	0.752
p.meth	0.777
p.rna	1.02e-12

Top 20 genes

Gene	meth	rna
GINS4	-4782.5	5306
GINS3	-4219.5	5085
RFC4	-4020.5	5263
MCM6	-3762.5	5157
MCM5	-4329.5	4324
RFC3	-3999.5	4648
MCM4	-3274.0	5206
GINS1	-2904.5	5275
MCM3	-2795.5	4970
MCM7	-2720.0	4817
PCNA	-2292.5	5048
RPA1	-2903.0	3959
RPA3	-3946.5	2513
PRIM2	-1875.5	5088
CDC45	-960.5	5318

Click HERE to show all gene set members

All member genes

	meth	rna
CDC45	-960.5	5318
DNA2	2418.5	5020
FEN1	519.5	5182
GINS1	-2904.5	5275
GINS3	-4219.5	5085
GINS4	-4782.5	5306
LIG1	3715.5	4095
MCM2	674.5	5209
MCM3	-2795.5	4970
MCM4	-3274.0	5206
MCM5	-4329.5	4324
MCM6	-3762.5	5157
MCM7	-2720.0	4817
MCM8	3129.0	5124
PCNA	-2292.5	5048
POLA1	3226.5	4151
POLA2	1188.5	4665
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RFC1	0.5	-301
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway

metric	value
setSize	10
pMANOVA	0.000482
p.adjustMANOVA	0.00207
s.dist	0.745
s.meth	0.556
s.rna	-0.495
p.meth	0.00233
p.rna	0.0067

Top 20 genes

Gene	meth	rna
HLA-C	3746.5	-3433
HLA-F	4391.5	-2864
HLA-B	4248.5	-2958
HLA-E	2626.5	-3686
HLA-A	2698.5	-1756
CTSL	3914.5	-765
CTSS	0.5	-4233

Click HERE to show all gene set members

All member genes

	meth	rna
B2M	-718.5	-3429
CTSL	3914.5	-765
CTSS	0.5	-4233
CTSV	3905.5	5178
HLA-A	2698.5	-1756
HLA-B	4248.5	-2958
HLA-C	3746.5	-3433
HLA-E	2626.5	-3686
HLA-F	4391.5	-2864
LNPEP	-2338.5	-1890

---

---

Mucopolysaccharidoses

Mucopolysaccharidoses

metric	value
setSize	11
pMANOVA	8.3e-05
p.adjustMANOVA	0.000426
s.dist	0.743
s.meth	-0.0981
s.rna	-0.737
p.meth	0.573
p.rna	2.33e-05

Top 20 genes

Gene	meth	rna
IDS	-4194.5	-4271
NAGLU	-3240.5	-4175
ARSB	-3616.5	-3576
SGSH	-1601.0	-2155
GALNS	-5004.5	-508

Click HERE to show all gene set members

All member genes

	meth	rna
ARSB	-3616.5	-3576
GALNS	-5004.5	-508
GLB1	1969.0	-4142
GNS	1580.5	-2905
GUSB	2297.5	-3448
HGSNAT	0.5	-2766
HYAL1	0.5	-4377
IDS	-4194.5	-4271
IDUA	1312.0	-2493
NAGLU	-3240.5	-4175
SGSH	-1601.0	-2155

---

---

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

metric	value
setSize	36
pMANOVA	2.11e-13
p.adjustMANOVA	5.89e-12
s.dist	0.741
s.meth	-0.0968
s.rna	0.735
p.meth	0.315
p.rna	2.28e-14

Top 20 genes

Gene	meth	rna
CDC25A	-4751.5	5309
RFC4	-4020.5	5263
MCM6	-3762.5	5157
MCM5	-4329.5	4324
RFC3	-3999.5	4648
MCM4	-3274.0	5206
ATR	-3361.5	4723
ORC6	-2966.5	5296
MCM3	-2795.5	4970
MCM7	-2720.0	4817
CHEK1	-2441.5	5234
CDC25C	-2173.5	5292
RPA1	-2903.0	3959
ORC2	-3133.5	3513
RPA3	-3946.5	2513
ORC5	-2220.5	4434
CDC45	-960.5	5318
RAD9A	-2543.5	1812
HUS1	-4031.5	1037

Click HERE to show all gene set members

All member genes

	meth	rna
ATR	-3361.5	4723
ATRIP	3480.5	2410
CDC25A	-4751.5	5309
CDC25C	-2173.5	5292
CDC45	-960.5	5318
CDC6	1904.5	5328
CDC7	2460.5	5155
CDK2	2631.5	3737
CHEK1	-2441.5	5234
CLSPN	1490.5	5220
DBF4	0.5	5161
HUS1	-4031.5	1037
MCM10	2300.5	5307
MCM2	674.5	5209
MCM3	-2795.5	4970
MCM4	-3274.0	5206
MCM5	-4329.5	4324
MCM6	-3762.5	5157
MCM7	-2720.0	4817
MCM8	3129.0	5124
ORC1	0.5	5223
ORC2	-3133.5	3513
ORC3	2903.5	2076
ORC4	906.0	186
ORC5	-2220.5	4434
ORC6	-2966.5	5296
RAD1	1863.0	2585
RAD17	-765.0	-150
RAD9A	-2543.5	1812
RAD9B	-2428.0	-4
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

Polo-like kinase mediated events

Polo-like kinase mediated events

metric	value
setSize	15
pMANOVA	1.18e-05
p.adjustMANOVA	7.25e-05
s.dist	0.727
s.meth	-0.231
s.rna	0.69
p.meth	0.122
p.rna	3.74e-06

Top 20 genes

Gene	meth	rna
CCNB1	-5222.5	5266
CDC25A	-4751.5	5309
FOXM1	-4669.5	5284
CENPF	-4477.5	5303
PLK1	-4522.5	5240
CDC25C	-2173.5	5292
LIN9	-1571.5	4680
WEE1	-3104.5	2053
RBBP4	-1172.0	3704
CCNB2	-591.5	5269

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-5222.5	5266
CCNB2	-591.5	5269
CDC25A	-4751.5	5309
CDC25C	-2173.5	5292
CENPF	-4477.5	5303
EP300	-1446.5	-771
FOXM1	-4669.5	5284
LIN37	3331.5	-67
LIN52	2800.0	2663
LIN54	3527.5	3099
LIN9	-1571.5	4680
PKMYT1	0.5	4904
PLK1	-4522.5	5240
RBBP4	-1172.0	3704
WEE1	-3104.5	2053

---

---

Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere

metric	value
setSize	22
pMANOVA	3.41e-08
p.adjustMANOVA	3.7e-07
s.dist	0.72
s.meth	-0.00931
s.rna	0.72
p.meth	0.94
p.rna	5e-09

Top 20 genes

Gene	meth	rna
CENPL	-4095.0	5021
ITGB3BP	-4480.0	4217
CENPM	-3571.5	5116
OIP5	-3478.0	5075
HJURP	-2566.5	5334
H2AFX	-2496.5	5036
CENPN	-2124.5	4786
CENPO	-1165.5	4924
RBBP4	-1172.0	3704

Click HERE to show all gene set members

All member genes

	meth	rna
CENPA	1018.5	5186
CENPH	928.5	5078
CENPI	2952.5	5264
CENPK	512.0	5134
CENPL	-4095.0	5021
CENPM	-3571.5	5116
CENPN	-2124.5	4786
CENPO	-1165.5	4924
CENPP	1049.0	5037
CENPQ	0.5	4830
CENPT	2063.5	-261
H2AFX	-2496.5	5036
HJURP	-2566.5	5334
ITGB3BP	-4480.0	4217
MIS18A	0.5	5087
MIS18BP1	0.5	1005
OIP5	-3478.0	5075
RBBP4	-1172.0	3704
RBBP7	1737.5	4286
RSF1	0.5	1971
RUVBL1	2851.5	4237
SMARCA5	605.5	-2933

---

---

Nucleosome assembly

Nucleosome assembly

metric	value
setSize	22
pMANOVA	3.41e-08
p.adjustMANOVA	3.7e-07
s.dist	0.72
s.meth	-0.00931
s.rna	0.72
p.meth	0.94
p.rna	5e-09

Top 20 genes

Gene	meth	rna
CENPL	-4095.0	5021
ITGB3BP	-4480.0	4217
CENPM	-3571.5	5116
OIP5	-3478.0	5075
HJURP	-2566.5	5334
H2AFX	-2496.5	5036
CENPN	-2124.5	4786
CENPO	-1165.5	4924
RBBP4	-1172.0	3704

Click HERE to show all gene set members

All member genes

	meth	rna
CENPA	1018.5	5186
CENPH	928.5	5078
CENPI	2952.5	5264
CENPK	512.0	5134
CENPL	-4095.0	5021
CENPM	-3571.5	5116
CENPN	-2124.5	4786
CENPO	-1165.5	4924
CENPP	1049.0	5037
CENPQ	0.5	4830
CENPT	2063.5	-261
H2AFX	-2496.5	5036
HJURP	-2566.5	5334
ITGB3BP	-4480.0	4217
MIS18A	0.5	5087
MIS18BP1	0.5	1005
OIP5	-3478.0	5075
RBBP4	-1172.0	3704
RBBP7	1737.5	4286
RSF1	0.5	1971
RUVBL1	2851.5	4237
SMARCA5	605.5	-2933

---

---

G1/S-Specific Transcription

G1/S-Specific Transcription

metric	value
setSize	28
pMANOVA	2.12e-09
p.adjustMANOVA	2.99e-08
s.dist	0.697
s.meth	-0.111
s.rna	0.688
p.meth	0.311
p.rna	2.9e-10

Top 20 genes

Gene	meth	rna
TYMS	-5177.5	5165
CDC25A	-4751.5	5309
RBL1	-4845.5	5003
CDT1	-4608.5	5199
TK1	-4428.0	5126
RRM2	-3394.5	5319
FBXO5	-3093.5	5200
TFDP2	-4208.5	3285
PCNA	-2292.5	5048
E2F6	-2487.5	3610
CCNE1	-1656.5	5159
E2F1	-2299.5	3633
LIN9	-1571.5	4680
CDC45	-960.5	5318
RBBP4	-1172.0	3704
CDK1	-467.5	5196
E2F4	-2073.5	359
E2F5	-805.5	129

Click HERE to show all gene set members

All member genes

	meth	rna
CCNE1	-1656.5	5159
CDC25A	-4751.5	5309
CDC45	-960.5	5318
CDC6	1904.5	5328
CDK1	-467.5	5196
CDT1	-4608.5	5199
DHFR	0.5	4328
E2F1	-2299.5	3633
E2F4	-2073.5	359
E2F5	-805.5	129
E2F6	-2487.5	3610
FBXO5	-3093.5	5200
HDAC1	2222.5	4784
LIN37	3331.5	-67
LIN52	2800.0	2663
LIN54	3527.5	3099
LIN9	-1571.5	4680
ORC1	0.5	5223
PCNA	-2292.5	5048
POLA1	3226.5	4151
RBBP4	-1172.0	3704
RBL1	-4845.5	5003
RBL2	1648.5	-2454
RRM2	-3394.5	5319
TFDP1	3217.5	2992
TFDP2	-4208.5	3285
TK1	-4428.0	5126
TYMS	-5177.5	5165

---

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

metric	value
setSize	13
pMANOVA	0.000195
p.adjustMANOVA	0.000912
s.dist	0.669
s.meth	-0.103
s.rna	0.661
p.meth	0.522
p.rna	3.72e-05

Top 20 genes

Gene	meth	rna
CCNB1	-5222.5	5266
CHEK1	-2441.5	5234
CDC25C	-2173.5	5292
YWHAZ	-1468.5	4714
WEE1	-3104.5	2053
YWHAE	-1698.5	2140
CDK1	-467.5	5196

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-5222.5	5266
CDC25C	-2173.5	5292
CDK1	-467.5	5196
CHEK1	-2441.5	5234
CHEK2	2421.0	5282
SFN	0.5	4611
WEE1	-3104.5	2053
YWHAB	0.5	3175
YWHAE	-1698.5	2140
YWHAG	1234.5	3258
YWHAH	-1695.5	-2443
YWHAQ	1925.5	3973
YWHAZ	-1468.5	4714

---

---

Condensation of Prophase Chromosomes

Condensation of Prophase Chromosomes

metric	value
setSize	13
pMANOVA	0.00024
p.adjustMANOVA	0.0011
s.dist	0.665
s.meth	-0.151
s.rna	0.647
p.meth	0.347
p.rna	5.32e-05

Top 20 genes

Gene	meth	rna
CCNB1	-5222.5	5266
PLK1	-4522.5	5240
SET	-3599.5	4264
SMC4	-2703.5	5024
H2AFX	-2496.5	5036
NCAPD3	-2111.0	4682
SMC2	-1986.5	4899
CDK1	-467.5	5196
MCPH1	-1785.5	157

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-5222.5	5266
CDK1	-467.5	5196
H2AFX	-2496.5	5036
MCPH1	-1785.5	157
NCAPD3	-2111.0	4682
NCAPG2	0.5	5118
NCAPH2	3485.0	-1637
PHF8	1931.5	3362
PLK1	-4522.5	5240
RB1	3728.5	301
SET	-3599.5	4264
SMC2	-1986.5	4899
SMC4	-2703.5	5024

---

---

Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication

metric	value
setSize	10
pMANOVA	0.00142
p.adjustMANOVA	0.00523
s.dist	0.662
s.meth	-0.0351
s.rna	0.661
p.meth	0.847
p.rna	0.000296

Top 20 genes

Gene	meth	rna
KPNA1	-3686.5	4599
ORC6	-2966.5	5296
H2AFX	-2496.5	5036
ORC2	-3133.5	3513
ORC5	-2220.5	4434

Click HERE to show all gene set members

All member genes

	meth	rna
H2AFX	-2496.5	5036
KPNA1	-3686.5	4599
KPNA6	2425.5	1774
KPNB1	1808.5	4619
ORC1	0.5	5223
ORC2	-3133.5	3513
ORC3	2903.5	2076
ORC4	906.0	186
ORC5	-2220.5	4434
ORC6	-2966.5	5296

---

---

Lagging Strand Synthesis

Lagging Strand Synthesis

metric	value
setSize	19
pMANOVA	2.01e-06
p.adjustMANOVA	1.44e-05
s.dist	0.661
s.meth	0.176
s.rna	0.637
p.meth	0.184
p.rna	1.52e-06

Top 20 genes

Gene	meth	rna
RFC2	3841.5	4684
PRIM1	3513.5	4630
LIG1	3715.5	4095
POLA1	3226.5	4151
DNA2	2418.5	5020
RFC5	1869.5	4942
POLD2	2117.5	3856
POLA2	1188.5	4665
FEN1	519.5	5182
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
DNA2	2418.5	5020
FEN1	519.5	5182
LIG1	3715.5	4095
PCNA	-2292.5	5048
POLA1	3226.5	4151
POLA2	1188.5	4665
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RFC1	0.5	-301
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

Processive synthesis on the lagging strand

Processive synthesis on the lagging strand

metric	value
setSize	14
pMANOVA	5.73e-05
p.adjustMANOVA	0.000302
s.dist	0.66
s.meth	0.238
s.rna	0.616
p.meth	0.124
p.rna	6.66e-05

Top 20 genes

Gene	meth	rna
PRIM1	3513.5	4630
LIG1	3715.5	4095
POLA1	3226.5	4151
DNA2	2418.5	5020
POLD2	2117.5	3856
POLA2	1188.5	4665
FEN1	519.5	5182
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
DNA2	2418.5	5020
FEN1	519.5	5182
LIG1	3715.5	4095
PCNA	-2292.5	5048
POLA1	3226.5	4151
POLA2	1188.5	4665
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis

metric	value
setSize	10
pMANOVA	0.00155
p.adjustMANOVA	0.00565
s.dist	0.654
s.meth	0.00407
s.rna	0.654
p.meth	0.982
p.rna	0.000343

Top 20 genes

Gene	meth	rna
PPAT	1982.0	5238
PAICS	1982.0	5185
PFAS	2172.5	3224
IMPDH2	814.5	4182

Click HERE to show all gene set members

All member genes

	meth	rna
ADSL	-4468.5	3796
ADSS	-1141.5	3708
ADSSL1	-2391.5	3160
ATIC	-5362.5	3647
GMPS	-1333.5	5058
IMPDH1	3205.5	-783
IMPDH2	814.5	4182
PAICS	1982.0	5185
PFAS	2172.5	3224
PPAT	1982.0	5238

---

---

Sema4D induced cell migration and growth-cone collapse

Sema4D induced cell migration and growth-cone collapse

metric	value
setSize	12
pMANOVA	0.000966
p.adjustMANOVA	0.00367
s.dist	0.648
s.meth	0.429
s.rna	-0.486
p.meth	0.0101
p.rna	0.00355

Top 20 genes

Gene	meth	rna
RHOB	4266.5	-4019
ERBB2	3341.5	-3463
MYL6	2552.5	-3890
MYH10	1978.5	-4201
RND1	3469.5	-2054
ROCK1	2416.5	-2100
MYH9	549.5	-278
ARHGEF12	0.5	-1761

Click HERE to show all gene set members

All member genes

	meth	rna
ARHGEF12	0.5	-1761
ERBB2	3341.5	-3463
LIMK1	3784.5	744
LIMK2	-836.5	510
MYH10	1978.5	-4201
MYH9	549.5	-278
MYL6	2552.5	-3890
RHOA	-2042.0	-3751
RHOB	4266.5	-4019
RND1	3469.5	-2054
ROCK1	2416.5	-2100
SEMA4D	0.5	998

---

---

Postmitotic nuclear pore complex (NPC) reformation

Postmitotic nuclear pore complex (NPC) reformation

metric	value
setSize	26
pMANOVA	1.18e-07
p.adjustMANOVA	1.15e-06
s.dist	0.648
s.meth	-0.118
s.rna	0.637
p.meth	0.3
p.rna	1.88e-08

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
NUP35	-2511.5	4381
RAN	-1824.5	4865
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AHCTF1	-1513.5	4818
NUP85	-1445.5	3232
RCC1	-869.5	4944
SUMO1	-2159.5	1645
NUP107	-554.5	4338
SEC13	-2360.5	837

Click HERE to show all gene set members

All member genes

	meth	rna
AHCTF1	-1513.5	4818
KPNB1	1808.5	4619
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
RAN	-1824.5	4865
RANGAP1	1029.5	4298
RCC1	-869.5	4944
SEC13	-2360.5	837
SEH1L	3148.5	3341
SUMO1	-2159.5	1645
TNPO1	1909.5	3632
UBE2I	888.5	3991

---

---

Cell-extracellular matrix interactions

Cell-extracellular matrix interactions

metric	value
setSize	11
pMANOVA	0.00147
p.adjustMANOVA	0.00537
s.dist	0.644
s.meth	0.207
s.rna	-0.61
p.meth	0.234
p.rna	0.00046

Top 20 genes

Gene	meth	rna
ARHGEF6	3821.5	-4200
LIMS2	3323.5	-4391
FLNA	3317.5	-3315
PXN	3496.5	-2418
VASP	2570.5	-2938
ILK	1639.5	-4117
TESK1	1288.5	-3047

Click HERE to show all gene set members

All member genes

	meth	rna
ACTN1	-3717.5	95
ARHGEF6	3821.5	-4200
FLNA	3317.5	-3315
ILK	1639.5	-4117
LIMS1	-4825.5	714
LIMS2	3323.5	-4391
PARVB	-3463.5	-1921
PXN	3496.5	-2418
RSU1	-1518.5	-2462
TESK1	1288.5	-3047
VASP	2570.5	-2938

---

---

PRC2 methylates histones and DNA

PRC2 methylates histones and DNA

metric	value
setSize	13
pMANOVA	3e-04
p.adjustMANOVA	0.00133
s.dist	0.638
s.meth	0.0537
s.rna	0.636
p.meth	0.737
p.rna	7.25e-05

Top 20 genes

Gene	meth	rna
DNMT3A	3883.5	3467
DNMT3B	2593.5	5018
EED	2044.5	4486
RBBP7	1737.5	4286
AEBP2	0.5	4267
JARID2	0.5	2640

Click HERE to show all gene set members

All member genes

	meth	rna
AEBP2	0.5	4267
DNMT1	-4537.5	4662
DNMT3A	3883.5	3467
DNMT3B	2593.5	5018
EED	2044.5	4486
EZH2	-4926.5	5229
H2AFX	-2496.5	5036
JARID2	0.5	2640
MTF2	-622.5	3601
PHF1	1530.5	-3348
PHF19	-781.5	3113
RBBP4	-1172.0	3704
RBBP7	1737.5	4286

---

---

Removal of the Flap Intermediate

Removal of the Flap Intermediate

metric	value
setSize	13
pMANOVA	0.000245
p.adjustMANOVA	0.00111
s.dist	0.635
s.meth	0.19
s.rna	0.605
p.meth	0.235
p.rna	0.000157

Top 20 genes

Gene	meth	rna
PRIM1	3513.5	4630
POLA1	3226.5	4151
DNA2	2418.5	5020
POLD2	2117.5	3856
POLA2	1188.5	4665
FEN1	519.5	5182
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
DNA2	2418.5	5020
FEN1	519.5	5182
PCNA	-2292.5	5048
POLA1	3226.5	4151
POLA2	1188.5	4665
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

metric	value
setSize	10
pMANOVA	0.00214
p.adjustMANOVA	0.00758
s.dist	0.634
s.meth	0.0456
s.rna	0.632
p.meth	0.803
p.rna	0.000537

Top 20 genes

Gene	meth	rna
SNRPD3	3057.5	4208
SNRPG	2575.5	4883
LSM11	2574.5	2573
ZNF473	2629.0	2149

Click HERE to show all gene set members

All member genes

	meth	rna
LSM10	-2880.5	505
LSM11	2574.5	2573
NCBP1	-3402.0	3337
NCBP2	-2007.5	4317
SLBP	-1707.5	3861
SNRPB	-1995.5	4571
SNRPD3	3057.5	4208
SNRPE	-1352.5	4947
SNRPG	2575.5	4883
ZNF473	2629.0	2149

---

---

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

metric	value
setSize	22
pMANOVA	1.31e-06
p.adjustMANOVA	9.8e-06
s.dist	0.633
s.meth	0.059
s.rna	0.631
p.meth	0.632
p.rna	3.07e-07

Top 20 genes

Gene	meth	rna
RBBP8	4231.5	4520
XRCC2	2958.5	5231
RMI2	2786.5	4428
DNA2	2418.5	5020
BRCA1	2267.0	5081
RMI1	2126.0	4292
BARD1	1275.5	4526
ATM	2065.0	891
RAD51B	1174.5	162
BRIP1	0.5	5280

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RBBP8	4231.5	4520
RMI1	2126.0	4292
RMI2	2786.5	4428
TOP3A	-3095.0	3812
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

metric	value
setSize	22
pMANOVA	1.31e-06
p.adjustMANOVA	9.8e-06
s.dist	0.633
s.meth	0.059
s.rna	0.631
p.meth	0.632
p.rna	3.07e-07

Top 20 genes

Gene	meth	rna
RBBP8	4231.5	4520
XRCC2	2958.5	5231
RMI2	2786.5	4428
DNA2	2418.5	5020
BRCA1	2267.0	5081
RMI1	2126.0	4292
BARD1	1275.5	4526
ATM	2065.0	891
RAD51B	1174.5	162
BRIP1	0.5	5280

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RBBP8	4231.5	4520
RMI1	2126.0	4292
RMI2	2786.5	4428
TOP3A	-3095.0	3812
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

metric	value
setSize	22
pMANOVA	1.31e-06
p.adjustMANOVA	9.8e-06
s.dist	0.633
s.meth	0.059
s.rna	0.631
p.meth	0.632
p.rna	3.07e-07

Top 20 genes

Gene	meth	rna
RBBP8	4231.5	4520
XRCC2	2958.5	5231
RMI2	2786.5	4428
DNA2	2418.5	5020
BRCA1	2267.0	5081
RMI1	2126.0	4292
BARD1	1275.5	4526
ATM	2065.0	891
RAD51B	1174.5	162
BRIP1	0.5	5280

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RBBP8	4231.5	4520
RMI1	2126.0	4292
RMI2	2786.5	4428
TOP3A	-3095.0	3812
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

metric	value
setSize	22
pMANOVA	1.31e-06
p.adjustMANOVA	9.8e-06
s.dist	0.633
s.meth	0.059
s.rna	0.631
p.meth	0.632
p.rna	3.07e-07

Top 20 genes

Gene	meth	rna
RBBP8	4231.5	4520
XRCC2	2958.5	5231
RMI2	2786.5	4428
DNA2	2418.5	5020
BRCA1	2267.0	5081
RMI1	2126.0	4292
BARD1	1275.5	4526
ATM	2065.0	891
RAD51B	1174.5	162
BRIP1	0.5	5280

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RBBP8	4231.5	4520
RMI1	2126.0	4292
RMI2	2786.5	4428
TOP3A	-3095.0	3812
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Impaired BRCA2 binding to PALB2

Impaired BRCA2 binding to PALB2

metric	value
setSize	22
pMANOVA	1.31e-06
p.adjustMANOVA	9.8e-06
s.dist	0.633
s.meth	0.059
s.rna	0.631
p.meth	0.632
p.rna	3.07e-07

Top 20 genes

Gene	meth	rna
RBBP8	4231.5	4520
XRCC2	2958.5	5231
RMI2	2786.5	4428
DNA2	2418.5	5020
BRCA1	2267.0	5081
RMI1	2126.0	4292
BARD1	1275.5	4526
ATM	2065.0	891
RAD51B	1174.5	162
BRIP1	0.5	5280

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RBBP8	4231.5	4520
RMI1	2126.0	4292
RMI2	2786.5	4428
TOP3A	-3095.0	3812
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Interactions of Rev with host cellular proteins

Interactions of Rev with host cellular proteins

metric	value
setSize	34
pMANOVA	3.32e-09
p.adjustMANOVA	4.39e-08
s.dist	0.631
s.meth	-0.159
s.rna	0.61
p.meth	0.109
p.rna	7.37e-10

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
RANBP1	-2500.0	4988
NUP35	-2511.5	4381
NUP210	-3025.5	3174
RAN	-1824.5	4865
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
XPO1	-1014.5	4790
NUP85	-1445.5	3232
RCC1	-869.5	4944
POM121C	-1519.5	2556
NUP107	-554.5	4338
NUP88	-544.0	4036
SEC13	-2360.5	837

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
KPNB1	1808.5	4619
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
POM121C	-1519.5	2556
RAE1	-4056.5	4758
RAN	-1824.5	4865
RANBP1	-2500.0	4988
RANBP2	2167.5	2106
RANGAP1	1029.5	4298
RCC1	-869.5	4944
SEC13	-2360.5	837
SEH1L	3148.5	3341
TPR	0.5	3125
XPO1	-1014.5	4790

---

---

Nucleotide biosynthesis

Nucleotide biosynthesis

metric	value
setSize	12
pMANOVA	0.000786
p.adjustMANOVA	0.00309
s.dist	0.631
s.meth	-0.0291
s.rna	0.63
p.meth	0.862
p.rna	0.000158

Top 20 genes

Gene	meth	rna
CAD	-4567.5	4622
ATIC	-5362.5	3647
ADSL	-4468.5	3796
ADSSL1	-2391.5	3160
GMPS	-1333.5	5058
ADSS	-1141.5	3708

Click HERE to show all gene set members

All member genes

	meth	rna
ADSL	-4468.5	3796
ADSS	-1141.5	3708
ADSSL1	-2391.5	3160
ATIC	-5362.5	3647
CAD	-4567.5	4622
DHODH	1713.5	1239
GMPS	-1333.5	5058
IMPDH1	3205.5	-783
IMPDH2	814.5	4182
PAICS	1982.0	5185
PFAS	2172.5	3224
PPAT	1982.0	5238

---

---

Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition

metric	value
setSize	22
pMANOVA	3.34e-06
p.adjustMANOVA	2.21e-05
s.dist	0.63
s.meth	-0.159
s.rna	0.61
p.meth	0.196
p.rna	7.47e-07

Top 20 genes

Gene	meth	rna
CCNB1	-5222.5	5266
CDC25A	-4751.5	5309
FOXM1	-4669.5	5284
PLK1	-4522.5	5240
CCNA2	-3131.5	5288
CDC25C	-2173.5	5292
PPP2R1B	-2314.5	3211
WEE1	-3104.5	2053
XPO1	-1014.5	4790
CCNB2	-591.5	5269
PPME1	-649.0	4635
CDK1	-467.5	5196
PPP2CA	-1107.5	1189

Click HERE to show all gene set members

All member genes

	meth	rna
CCNA2	-3131.5	5288
CCNB1	-5222.5	5266
CCNB2	-591.5	5269
CCNH	-1238.5	-2215
CDC25A	-4751.5	5309
CDC25B	3215.5	2685
CDC25C	-2173.5	5292
CDK1	-467.5	5196
CDK2	2631.5	3737
CDK7	3191.5	3386
FOXM1	-4669.5	5284
LCMT1	0.5	1883
MNAT1	0.5	3875
PKMYT1	0.5	4904
PLK1	-4522.5	5240
PPME1	-649.0	4635
PPP2CA	-1107.5	1189
PPP2CB	-3790.5	-3815
PPP2R1B	-2314.5	3211
PPP2R2A	2149.5	2790
WEE1	-3104.5	2053
XPO1	-1014.5	4790

---

---

Rev-mediated nuclear export of HIV RNA

Rev-mediated nuclear export of HIV RNA

metric	value
setSize	33
pMANOVA	7.39e-09
p.adjustMANOVA	9.17e-08
s.dist	0.629
s.meth	-0.178
s.rna	0.603
p.meth	0.0769
p.rna	2.07e-09

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
RANBP1	-2500.0	4988
NUP35	-2511.5	4381
NUP210	-3025.5	3174
RAN	-1824.5	4865
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
XPO1	-1014.5	4790
NUP85	-1445.5	3232
RCC1	-869.5	4944
POM121C	-1519.5	2556
NUP107	-554.5	4338
NUP88	-544.0	4036
SEC13	-2360.5	837

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
POM121C	-1519.5	2556
RAE1	-4056.5	4758
RAN	-1824.5	4865
RANBP1	-2500.0	4988
RANBP2	2167.5	2106
RANGAP1	1029.5	4298
RCC1	-869.5	4944
SEC13	-2360.5	837
SEH1L	3148.5	3341
TPR	0.5	3125
XPO1	-1014.5	4790

---

---

Leading Strand Synthesis

Leading Strand Synthesis

metric	value
setSize	14
pMANOVA	0.000149
p.adjustMANOVA	0.000713
s.dist	0.628
s.meth	0.207
s.rna	0.593
p.meth	0.18
p.rna	0.000122

Top 20 genes

Gene	meth	rna
RFC2	3841.5	4684
PRIM1	3513.5	4630
POLA1	3226.5	4151
RFC5	1869.5	4942
POLD2	2117.5	3856
POLA2	1188.5	4665
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
PCNA	-2292.5	5048
POLA1	3226.5	4151
POLA2	1188.5	4665
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RFC1	0.5	-301
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942

---

---

Polymerase switching

Polymerase switching

metric	value
setSize	14
pMANOVA	0.000149
p.adjustMANOVA	0.000713
s.dist	0.628
s.meth	0.207
s.rna	0.593
p.meth	0.18
p.rna	0.000122

Top 20 genes

Gene	meth	rna
RFC2	3841.5	4684
PRIM1	3513.5	4630
POLA1	3226.5	4151
RFC5	1869.5	4942
POLD2	2117.5	3856
POLA2	1188.5	4665
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
PCNA	-2292.5	5048
POLA1	3226.5	4151
POLA2	1188.5	4665
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
PRIM1	3513.5	4630
PRIM2	-1875.5	5088
RFC1	0.5	-301
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942

---

---

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

metric	value
setSize	21
pMANOVA	2.22e-06
p.adjustMANOVA	1.58e-05
s.dist	0.627
s.meth	0.153
s.rna	0.609
p.meth	0.226
p.rna	1.38e-06

Top 20 genes

Gene	meth	rna
POLE2	4349.5	5252
RFC2	3841.5	4684
LIG1	3715.5	4095
PARP2	3864.5	3416
RFC5	1869.5	4942
POLE3	2378.0	3771
POLE	1888.0	4607
POLD2	2117.5	3856
POLB	819.5	4892
FEN1	519.5	5182
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
FEN1	519.5	5182
LIG1	3715.5	4095
PARP1	-2643.5	4757
PARP2	3864.5	3416
PCNA	-2292.5	5048
POLB	819.5	4892
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
POLE	1888.0	4607
POLE2	4349.5	5252
POLE3	2378.0	3771
POLE4	-3816.5	1032
RFC1	0.5	-301
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

metric	value
setSize	24
pMANOVA	7.7e-07
p.adjustMANOVA	6.11e-06
s.dist	0.618
s.meth	0.0603
s.rna	0.615
p.meth	0.609
p.rna	1.84e-07

Top 20 genes

Gene	meth	rna
RBBP8	4231.5	4520
XRCC2	2958.5	5231
RMI2	2786.5	4428
DNA2	2418.5	5020
BRCA1	2267.0	5081
RMI1	2126.0	4292
BARD1	1275.5	4526
XRCC3	514.0	3767
ATM	2065.0	891
RAD51B	1174.5	162
BRIP1	0.5	5280

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RBBP8	4231.5	4520
RMI1	2126.0	4292
RMI2	2786.5	4428
RTEL1	-733.5	1437
TOP3A	-3095.0	3812
WRN	-980.5	3527
XRCC2	2958.5	5231
XRCC3	514.0	3767

---

---

Homologous DNA Pairing and Strand Exchange

Homologous DNA Pairing and Strand Exchange

metric	value
setSize	39
pMANOVA	3.2e-10
p.adjustMANOVA	5.61e-09
s.dist	0.616
s.meth	-0.0749
s.rna	0.612
p.meth	0.419
p.rna	3.86e-11

Top 20 genes

Gene	meth	rna
TOPBP1	-4988.5	4978
BRCA2	-4801.5	4542
RFC4	-4020.5	5263
EXO1	-3552.5	5298
RFC3	-3999.5	4648
RHNO1	-4803.5	3690
ATR	-3361.5	4723
RAD51AP1	-2550.0	5176
RAD51	-2525.5	5100
CHEK1	-2441.5	5234
TOP3A	-3095.0	3812
RPA1	-2903.0	3959
PALB2	-2275.0	4661
RPA3	-3946.5	2513
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
HUS1	-4031.5	1037
BLM	-704.5	5310
WRN	-980.5	3527
NBN	-1345.5	1188

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
ATR	-3361.5	4723
ATRIP	3480.5	2410
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
CHEK1	-2441.5	5234
DNA2	2418.5	5020
EXO1	-3552.5	5298
HUS1	-4031.5	1037
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD1	1863.0	2585
RAD17	-765.0	-150
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
RAD9B	-2428.0	-4
RBBP8	4231.5	4520
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RHNO1	-4803.5	3690
RMI1	2126.0	4292
RMI2	2786.5	4428
RPA1	-2903.0	3959
RPA3	-3946.5	2513
TOP3A	-3095.0	3812
TOPBP1	-4988.5	4978
WRN	-980.5	3527
XRCC2	2958.5	5231
XRCC3	514.0	3767

---

---

PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair

metric	value
setSize	19
pMANOVA	1.4e-05
p.adjustMANOVA	8.41e-05
s.dist	0.612
s.meth	0.145
s.rna	0.594
p.meth	0.273
p.rna	7.36e-06

Top 20 genes

Gene	meth	rna
POLE2	4349.5	5252
RFC2	3841.5	4684
LIG1	3715.5	4095
RFC5	1869.5	4942
POLE3	2378.0	3771
POLE	1888.0	4607
POLD2	2117.5	3856
POLB	819.5	4892
FEN1	519.5	5182
POLD1	718.5	2758
POLD3	2533.5	208

Click HERE to show all gene set members

All member genes

	meth	rna
FEN1	519.5	5182
LIG1	3715.5	4095
PCNA	-2292.5	5048
POLB	819.5	4892
POLD1	718.5	2758
POLD2	2117.5	3856
POLD3	2533.5	208
POLD4	713.5	-2834
POLE	1888.0	4607
POLE2	4349.5	5252
POLE3	2378.0	3771
POLE4	-3816.5	1032
RFC1	0.5	-301
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RPA1	-2903.0	3959
RPA3	-3946.5	2513

---

---

Nuclear import of Rev protein

Nuclear import of Rev protein

metric	value
setSize	31
pMANOVA	6.82e-08
p.adjustMANOVA	7.04e-07
s.dist	0.608
s.meth	-0.167
s.rna	0.585
p.meth	0.107
p.rna	1.75e-08

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
NUP35	-2511.5	4381
NUP210	-3025.5	3174
RAN	-1824.5	4865
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
NUP85	-1445.5	3232
RCC1	-869.5	4944
POM121C	-1519.5	2556
NUP107	-554.5	4338
NUP88	-544.0	4036
SEC13	-2360.5	837
NUP153	-712.5	2506

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
KPNB1	1808.5	4619
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
POM121C	-1519.5	2556
RAE1	-4056.5	4758
RAN	-1824.5	4865
RANBP2	2167.5	2106
RCC1	-869.5	4944
SEC13	-2360.5	837
SEH1L	3148.5	3341
TPR	0.5	3125

---

---

NEP/NS2 Interacts with the Cellular Export Machinery

NEP/NS2 Interacts with the Cellular Export Machinery

metric	value
setSize	30
pMANOVA	1.51e-07
p.adjustMANOVA	1.44e-06
s.dist	0.605
s.meth	-0.19
s.rna	0.575
p.meth	0.0725
p.rna	5.1e-08

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
NUP35	-2511.5	4381
NUP210	-3025.5	3174
RAN	-1824.5	4865
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
XPO1	-1014.5	4790
NUP85	-1445.5	3232
POM121C	-1519.5	2556
NUP107	-554.5	4338
NUP88	-544.0	4036
SEC13	-2360.5	837
NUP153	-712.5	2506

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
POM121C	-1519.5	2556
RAE1	-4056.5	4758
RAN	-1824.5	4865
RANBP2	2167.5	2106
SEC13	-2360.5	837
SEH1L	3148.5	3341
TPR	0.5	3125
XPO1	-1014.5	4790

---

---

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

metric	value
setSize	37
pMANOVA	2.2e-09
p.adjustMANOVA	3.03e-08
s.dist	0.604
s.meth	-0.0735
s.rna	0.6
p.meth	0.439
p.rna	2.77e-10

Top 20 genes

Gene	meth	rna
TOPBP1	-4988.5	4978
BRCA2	-4801.5	4542
RFC4	-4020.5	5263
EXO1	-3552.5	5298
RFC3	-3999.5	4648
RHNO1	-4803.5	3690
ATR	-3361.5	4723
RAD51AP1	-2550.0	5176
RAD51	-2525.5	5100
TOP3A	-3095.0	3812
RPA1	-2903.0	3959
PALB2	-2275.0	4661
RPA3	-3946.5	2513
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
HUS1	-4031.5	1037
BLM	-704.5	5310
WRN	-980.5	3527
NBN	-1345.5	1188
RAD50	-3668.5	63

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
ATR	-3361.5	4723
ATRIP	3480.5	2410
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
HUS1	-4031.5	1037
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD1	1863.0	2585
RAD17	-765.0	-150
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
RAD9B	-2428.0	-4
RBBP8	4231.5	4520
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RHNO1	-4803.5	3690
RMI1	2126.0	4292
RMI2	2786.5	4428
RPA1	-2903.0	3959
RPA3	-3946.5	2513
TOP3A	-3095.0	3812
TOPBP1	-4988.5	4978
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Diseases of DNA Double-Strand Break Repair

Diseases of DNA Double-Strand Break Repair

metric	value
setSize	37
pMANOVA	2.2e-09
p.adjustMANOVA	3.03e-08
s.dist	0.604
s.meth	-0.0735
s.rna	0.6
p.meth	0.439
p.rna	2.77e-10

Top 20 genes

Gene	meth	rna
TOPBP1	-4988.5	4978
BRCA2	-4801.5	4542
RFC4	-4020.5	5263
EXO1	-3552.5	5298
RFC3	-3999.5	4648
RHNO1	-4803.5	3690
ATR	-3361.5	4723
RAD51AP1	-2550.0	5176
RAD51	-2525.5	5100
TOP3A	-3095.0	3812
RPA1	-2903.0	3959
PALB2	-2275.0	4661
RPA3	-3946.5	2513
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
HUS1	-4031.5	1037
BLM	-704.5	5310
WRN	-980.5	3527
NBN	-1345.5	1188
RAD50	-3668.5	63

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
ATR	-3361.5	4723
ATRIP	3480.5	2410
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
HUS1	-4031.5	1037
KAT5	2573.5	-3674
NBN	-1345.5	1188
PALB2	-2275.0	4661
RAD1	1863.0	2585
RAD17	-765.0	-150
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51AP1	-2550.0	5176
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
RAD9B	-2428.0	-4
RBBP8	4231.5	4520
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RHNO1	-4803.5	3690
RMI1	2126.0	4292
RMI2	2786.5	4428
RPA1	-2903.0	3959
RPA3	-3946.5	2513
TOP3A	-3095.0	3812
TOPBP1	-4988.5	4978
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Meiotic recombination

Meiotic recombination

metric	value
setSize	19
pMANOVA	3.69e-05
p.adjustMANOVA	0.000203
s.dist	0.604
s.meth	-0.0821
s.rna	0.598
p.meth	0.536
p.rna	6.38e-06

Top 20 genes

Gene	meth	rna
BRCA2	-4801.5	4542
RAD51	-2525.5	5100
H2AFX	-2496.5	5036
TOP3A	-3095.0	3812
RPA1	-2903.0	3959
RPA3	-3946.5	2513
DMC1	-3069.5	3137
MND1	-1269.5	5247
PSMC3IP	-1813.5	3331
BLM	-704.5	5310
NBN	-1345.5	1188
RAD50	-3668.5	63

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
CDK2	2631.5	3737
CDK4	1516.5	4946
DMC1	-3069.5	3137
H2AFX	-2496.5	5036
MLH3	0.5	-249
MND1	-1269.5	5247
MSH5	2296.5	1786
NBN	-1345.5	1188
PSMC3IP	-1813.5	3331
RAD50	-3668.5	63
RAD51	-2525.5	5100
RBBP8	4231.5	4520
RPA1	-2903.0	3959
RPA3	-3946.5	2513
TOP3A	-3095.0	3812

---

---

Vpr-mediated nuclear import of PICs

Vpr-mediated nuclear import of PICs

metric	value
setSize	32
pMANOVA	8.03e-08
p.adjustMANOVA	8.08e-07
s.dist	0.601
s.meth	-0.225
s.rna	0.557
p.meth	0.0278
p.rna	5.02e-08

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
KPNA1	-3686.5	4599
NUP35	-2511.5	4381
NUP210	-3025.5	3174
BANF1	-3378.0	2528
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
NUP85	-1445.5	3232
PSIP1	-4092.5	1077
POM121C	-1519.5	2556
NUP107	-554.5	4338
NUP88	-544.0	4036
SEC13	-2360.5	837
NUP153	-712.5	2506

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
BANF1	-3378.0	2528
HMGA1	0.5	5127
KPNA1	-3686.5	4599
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
POM121C	-1519.5	2556
PSIP1	-4092.5	1077
RAE1	-4056.5	4758
RANBP2	2167.5	2106
SEC13	-2360.5	837
SEH1L	3148.5	3341
TPR	0.5	3125

---

---

Transport of Ribonucleoproteins into the Host Nucleus

Transport of Ribonucleoproteins into the Host Nucleus

metric	value
setSize	30
pMANOVA	1.9e-07
p.adjustMANOVA	1.76e-06
s.dist	0.6
s.meth	-0.183
s.rna	0.572
p.meth	0.083
p.rna	5.98e-08

Top 20 genes

Gene	meth	rna
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
KPNA1	-3686.5	4599
NUP35	-2511.5	4381
NUP210	-3025.5	3174
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
NUP85	-1445.5	3232
POM121C	-1519.5	2556
NUP107	-554.5	4338
NUP88	-544.0	4036
SEC13	-2360.5	837
NUP153	-712.5	2506

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
KPNA1	-3686.5	4599
KPNB1	1808.5	4619
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
POM121	3523.5	1351
POM121C	-1519.5	2556
RAE1	-4056.5	4758
RANBP2	2167.5	2106
SEC13	-2360.5	837
SEH1L	3148.5	3341
TPR	0.5	3125

---

---

Presynaptic phase of homologous DNA pairing and strand exchange

Presynaptic phase of homologous DNA pairing and strand exchange

metric	value
setSize	36
pMANOVA	6.03e-09
p.adjustMANOVA	7.63e-08
s.dist	0.596
s.meth	-0.0647
s.rna	0.593
p.meth	0.502
p.rna	7.68e-10

Top 20 genes

Gene	meth	rna
TOPBP1	-4988.5	4978
BRCA2	-4801.5	4542
RFC4	-4020.5	5263
EXO1	-3552.5	5298
RFC3	-3999.5	4648
RHNO1	-4803.5	3690
ATR	-3361.5	4723
RAD51	-2525.5	5100
CHEK1	-2441.5	5234
TOP3A	-3095.0	3812
RPA1	-2903.0	3959
RPA3	-3946.5	2513
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
HUS1	-4031.5	1037
BLM	-704.5	5310
WRN	-980.5	3527
NBN	-1345.5	1188
RAD50	-3668.5	63

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
ATR	-3361.5	4723
ATRIP	3480.5	2410
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
CHEK1	-2441.5	5234
DNA2	2418.5	5020
EXO1	-3552.5	5298
HUS1	-4031.5	1037
KAT5	2573.5	-3674
NBN	-1345.5	1188
RAD1	1863.0	2585
RAD17	-765.0	-150
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD51B	1174.5	162
RAD51D	-2460.5	3074
RAD9A	-2543.5	1812
RAD9B	-2428.0	-4
RBBP8	4231.5	4520
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RHNO1	-4803.5	3690
RMI1	2126.0	4292
RMI2	2786.5	4428
RPA1	-2903.0	3959
RPA3	-3946.5	2513
TOP3A	-3095.0	3812
TOPBP1	-4988.5	4978
WRN	-980.5	3527
XRCC2	2958.5	5231

---

---

Impaired BRCA2 binding to RAD51

Impaired BRCA2 binding to RAD51

metric	value
setSize	32
pMANOVA	5.54e-08
p.adjustMANOVA	5.81e-07
s.dist	0.595
s.meth	-0.08
s.rna	0.59
p.meth	0.434
p.rna	7.71e-09

Top 20 genes

Gene	meth	rna
TOPBP1	-4988.5	4978
BRCA2	-4801.5	4542
RFC4	-4020.5	5263
EXO1	-3552.5	5298
RFC3	-3999.5	4648
RHNO1	-4803.5	3690
ATR	-3361.5	4723
RAD51	-2525.5	5100
TOP3A	-3095.0	3812
RPA1	-2903.0	3959
RPA3	-3946.5	2513
RAD9A	-2543.5	1812
HUS1	-4031.5	1037
BLM	-704.5	5310
WRN	-980.5	3527
NBN	-1345.5	1188
RAD50	-3668.5	63

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	2065.0	891
ATR	-3361.5	4723
ATRIP	3480.5	2410
BARD1	1275.5	4526
BLM	-704.5	5310
BRCA1	2267.0	5081
BRCA2	-4801.5	4542
BRIP1	0.5	5280
DNA2	2418.5	5020
EXO1	-3552.5	5298
HUS1	-4031.5	1037
KAT5	2573.5	-3674
NBN	-1345.5	1188
RAD1	1863.0	2585
RAD17	-765.0	-150
RAD50	-3668.5	63
RAD51	-2525.5	5100
RAD9A	-2543.5	1812
RAD9B	-2428.0	-4
RBBP8	4231.5	4520
RFC2	3841.5	4684
RFC3	-3999.5	4648
RFC4	-4020.5	5263
RFC5	1869.5	4942
RHNO1	-4803.5	3690
RMI1	2126.0	4292
RMI2	2786.5	4428
RPA1	-2903.0	3959
RPA3	-3946.5	2513
TOP3A	-3095.0	3812
TOPBP1	-4988.5	4978
WRN	-980.5	3527

---

---

Sema4D in semaphorin signaling

Sema4D in semaphorin signaling

metric	value
setSize	15
pMANOVA	0.000697
p.adjustMANOVA	0.00284
s.dist	0.593
s.meth	0.378
s.rna	-0.457
p.meth	0.0113
p.rna	0.00219

Top 20 genes

Gene	meth	rna
RHOB	4266.5	-4019
ERBB2	3341.5	-3463
MYL6	2552.5	-3890
MYH10	1978.5	-4201
RND1	3469.5	-2054
ROCK1	2416.5	-2100
MYH9	549.5	-278
ARHGEF12	0.5	-1761
ARHGAP35	0.5	-1349

Click HERE to show all gene set members

All member genes

	meth	rna
ARHGAP35	0.5	-1349
ARHGEF12	0.5	-1761
ERBB2	3341.5	-3463
LIMK1	3784.5	744
LIMK2	-836.5	510
MYH10	1978.5	-4201
MYH9	549.5	-278
MYL6	2552.5	-3890
RAC1	2036.5	1934
RHOA	-2042.0	-3751
RHOB	4266.5	-4019
RND1	3469.5	-2054
ROCK1	2416.5	-2100
RRAS	-899.5	-4247
SEMA4D	0.5	998

---

---

SUMOylation of DNA replication proteins

SUMOylation of DNA replication proteins

metric	value
setSize	43
pMANOVA	3.83e-10
p.adjustMANOVA	6.62e-09
s.dist	0.59
s.meth	-0.129
s.rna	0.575
p.meth	0.145
p.rna	6.74e-11

Top 20 genes

Gene	meth	rna
AURKB	-5157.5	5265
BIRC5	-4671.5	5286
NUP133	-5066.5	4087
NUP155	-3994.5	4994
RAE1	-4056.5	4758
NUP37	-3884.5	4745
NUP62	-4188.0	4260
NUP43	-4127.5	4306
PCNA	-2292.5	5048
NUP35	-2511.5	4381
NUP210	-3025.5	3174
INCENP	-1925.5	4708
NUP160	-3491.5	2430
NUP93	-2685.5	3079
AAAS	-3430.5	1571
NUP85	-1445.5	3232
TOP1	-3784.5	1125
POM121C	-1519.5	2556
SUMO1	-2159.5	1645
NUP107	-554.5	4338

Click HERE to show all gene set members

All member genes

	meth	rna
AAAS	-3430.5	1571
AURKA	2074.0	5210
AURKB	-5157.5	5265
BIRC5	-4671.5	5286
CDCA8	0.5	5278
INCENP	-1925.5	4708
NDC1	0.5	4955
NUP107	-554.5	4338
NUP133	-5066.5	4087
NUP153	-712.5	2506
NUP155	-3994.5	4994
NUP160	-3491.5	2430
NUP188	1317.0	2197
NUP205	2840.5	4406
NUP210	-3025.5	3174
NUP214	-3211.5	-366
NUP35	-2511.5	4381
NUP37	-3884.5	4745
NUP43	-4127.5	4306
NUP50	1707.5	4742
NUP54	473.5	3320
NUP62	-4188.0	4260
NUP85	-1445.5	3232
NUP88	-544.0	4036
NUP93	-2685.5	3079
NUP98	-3524.5	-674
PCNA	-2292.5	5048
PIAS3	948.5	2485
PIAS4	3047.5	428
POM121	3523.5	1351
POM121C	-1519.5	2556
RAE1	-4056.5	4758
RANBP2	2167.5	2106
RANGAP1	1029.5	4298
SEC13	-2360.5	837
SEH1L	3148.5	3341
SUMO1	-2159.5	1645
SUMO3	3078.5	1042
TOP1	-3784.5	1125
TOP2A	1426.5	5330
TOP2B	-726.5	697
TPR	0.5	3125
UBE2I	888.5	3991

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      parallel  stats4    stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] dplyr_1.0.9                                        
##  [7] echarts4r_0.4.3                                    
##  [8] kableExtra_1.3.4                                   
##  [9] mitch_1.8.0                                        
## [10] tictoc_1.0.1                                       
## [11] ENmix_1.32.0                                       
## [12] doParallel_1.0.17                                  
## [13] qqman_0.1.8                                        
## [14] RCircos_1.2.2                                      
## [15] beeswarm_0.4.0                                     
## [16] forestplot_2.0.1                                   
## [17] checkmate_2.1.0                                    
## [18] magrittr_2.0.3                                     
## [19] reshape2_1.4.4                                     
## [20] gplots_3.1.3                                       
## [21] eulerr_6.1.1                                       
## [22] GEOquery_2.64.2                                    
## [23] RColorBrewer_1.1-3                                 
## [24] IlluminaHumanMethylation450kmanifest_0.4.0         
## [25] topconfects_1.12.0                                 
## [26] DMRcatedata_2.14.0                                 
## [27] ExperimentHub_2.4.0                                
## [28] AnnotationHub_3.4.0                                
## [29] BiocFileCache_2.4.0                                
## [30] dbplyr_2.1.1                                       
## [31] DMRcate_2.10.0                                     
## [32] limma_3.52.1                                       
## [33] missMethyl_1.30.0                                  
## [34] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [35] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [36] minfi_1.42.0                                       
## [37] bumphunter_1.38.0                                  
## [38] locfit_1.5-9.5                                     
## [39] iterators_1.0.14                                   
## [40] foreach_1.5.2                                      
## [41] Biostrings_2.64.0                                  
## [42] XVector_0.36.0                                     
## [43] SummarizedExperiment_1.26.1                        
## [44] Biobase_2.56.0                                     
## [45] MatrixGenerics_1.8.0                               
## [46] matrixStats_0.62.0                                 
## [47] GenomicRanges_1.48.0                               
## [48] GenomeInfoDb_1.32.2                                
## [49] IRanges_2.30.0                                     
## [50] S4Vectors_0.34.0                                   
## [51] BiocGenerics_0.42.0                                
## [52] R.utils_2.11.0                                     
## [53] R.oo_1.24.0                                        
## [54] R.methodsS3_1.8.1                                  
## [55] plyr_1.8.7                                         
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] jquerylib_0.1.4               hms_1.1.1                    
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             labeling_0.4.2               
##  [61] edgeR_3.38.1                  pkgconfig_2.0.3              
##  [63] nlme_3.1-157                  ProtGenerics_1.28.0          
##  [65] nnet_7.3-17                   rlang_1.0.2                  
##  [67] lifecycle_1.0.1               filelock_1.0.2               
##  [69] dichromat_2.0-0.1             rprojroot_2.0.3              
##  [71] cellranger_1.1.0              rngtools_1.5.2               
##  [73] base64_2.0                    Matrix_1.4-1                 
##  [75] Rhdf5lib_1.18.2               base64enc_0.1-3              
##  [77] viridisLite_0.4.0             png_0.1-7                    
##  [79] rjson_0.2.21                  bitops_1.0-7                 
##  [81] KernSmooth_2.23-20            rhdf5filters_1.8.0           
##  [83] blob_1.2.3                    DelayedMatrixStats_1.18.0    
##  [85] doRNG_1.8.2                   stringr_1.4.0                
##  [87] nor1mix_1.3-0                 readr_2.1.2                  
##  [89] jpeg_0.1-9                    scales_1.2.0                 
##  [91] memoise_2.0.1                 zlibbioc_1.42.0              
##  [93] compiler_4.2.0                BiocIO_1.6.0                 
##  [95] illuminaio_0.38.0             Rsamtools_2.12.0             
##  [97] cli_3.3.0                     DSS_2.44.0                   
##  [99] htmlTable_2.4.0               Formula_1.2-4                
## [101] MASS_7.3-57                   tidyselect_1.1.2             
## [103] stringi_1.7.6                 highr_0.9                    
## [105] yaml_2.3.5                    askpass_1.1                  
## [107] latticeExtra_0.6-29           sass_0.4.1                   
## [109] VariantAnnotation_1.42.1      tools_4.2.0                  
## [111] rstudioapi_0.13               foreign_0.8-82               
## [113] bsseq_1.32.0                  gridExtra_2.3                
## [115] farver_2.1.0                  digest_0.6.29                
## [117] BiocManager_1.30.17           shiny_1.7.1                  
## [119] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [121] siggenes_1.70.0               BiocVersion_3.15.2           
## [123] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [125] httr_1.4.3                    AnnotationDbi_1.58.0         
## [127] biovizBase_1.44.0             colorspace_2.0-3             
## [129] brio_1.1.3                    rvest_1.0.2                  
## [131] XML_3.99-0.9                  splines_4.2.0                
## [133] statmod_1.4.36                multtest_2.52.0              
## [135] systemfonts_1.0.4             xtable_1.8-4                 
## [137] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [139] testthat_3.1.4                R6_2.5.1                     
## [141] Hmisc_4.7-0                   pillar_1.7.0                 
## [143] htmltools_0.5.2               mime_0.12                    
## [145] glue_1.6.2                    fastmap_1.1.0                
## [147] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [149] beanplot_1.3.1                codetools_0.2-18             
## [151] utf8_1.2.2                    bslib_0.3.1                  
## [153] lattice_0.20-45               curl_4.3.2                   
## [155] openssl_2.0.1                 survival_3.3-1               
## [157] rmarkdown_2.14                desc_1.4.1                   
## [159] munsell_0.5.0                 rhdf5_2.40.0                 
## [161] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [163] impute_1.70.0                 gtable_0.3.0

END of report