Mitch Report

date generated: 2022-05-25

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                meth        rna
## A1BG      2.6702453 -1.2732462
## A2M      -2.1002521 -9.1103749
## A2ML1   -10.1550168  8.6692951
## A3GALT2  -8.0204776 -0.1813287
## A4GALT   -0.7194641  5.1040216
## AAAS     -0.8729370  1.9841004

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	16350
duplicated_genes_present	0
num_profile_genes_in_sets	9480
num_profile_genes_not_in_sets	6870
profile_pearson_correl	0.04738
profile_spearman_correl	-0.03008

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ../ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1042
num_genesets_included	1504

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 700

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.meth	s.rna	p.meth	p.rna
Unwinding of DNA	12	1.14e-07	1.25e-06	0.944	-0.0770	0.9410	6.44e-01	1.64e-08
Defective pyroptosis	13	1.23e-06	1.02e-05	0.831	0.1540	0.8160	3.36e-01	3.47e-07
Condensation of Prometaphase Chromosomes	11	3.56e-05	1.91e-04	0.785	0.0860	0.7800	6.22e-01	7.39e-06
Endosomal/Vacuolar pathway	11	8.77e-05	4.17e-04	0.763	0.6210	-0.4430	3.58e-04	1.10e-02
DNA strand elongation	32	3.96e-12	1.08e-10	0.738	0.0389	0.7370	7.04e-01	5.14e-13
Activation of the pre-replicative complex	33	1.96e-12	5.68e-11	0.735	0.0792	0.7310	4.31e-01	3.51e-13
Activation of ATR in response to replication stress	37	2.69e-13	8.99e-12	0.719	0.0975	0.7130	3.05e-01	6.17e-14
Mucopolysaccharidoses	11	2.10e-04	8.94e-04	0.714	-0.0698	-0.7110	6.89e-01	4.46e-05
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	4.49e-04	1.74e-03	0.706	0.4470	0.5470	1.45e-02	2.73e-03
Digestion	11	2.81e-04	1.16e-03	0.706	-0.7020	0.0718	5.50e-05	6.80e-01
SLBP independent Processing of Histone Pre-mRNAs	10	4.68e-04	1.80e-03	0.706	0.3380	0.6200	6.41e-02	6.92e-04
Polo-like kinase mediated events	16	9.21e-06	5.87e-05	0.697	-0.0747	0.6930	6.05e-01	1.58e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	3.05e-04	1.24e-03	0.692	0.3040	0.6220	8.14e-02	3.54e-04
Deposition of new CENPA-containing nucleosomes at the centromere	25	1.48e-08	2.02e-07	0.691	0.0630	0.6890	5.86e-01	2.50e-09
Nucleosome assembly	25	1.48e-08	2.02e-07	0.691	0.0630	0.6890	5.86e-01	2.50e-09
Phosphorylation of CD3 and TCR zeta chains	20	7.37e-07	6.59e-06	0.677	-0.3210	-0.5960	1.28e-02	3.88e-06
Response to metal ions	11	7.38e-04	2.69e-03	0.663	0.6600	-0.0531	1.49e-04	7.61e-01
Purine ribonucleoside monophosphate biosynthesis	11	7.87e-04	2.82e-03	0.655	0.1080	0.6460	5.35e-01	2.08e-04
G1/S-Specific Transcription	29	1.05e-08	1.50e-07	0.648	0.0483	0.6470	6.53e-01	1.65e-09
Assembly of the ORC complex at the origin of replication	10	1.75e-03	5.67e-03	0.647	0.1160	0.6370	5.25e-01	4.90e-04
Regulation of FOXO transcriptional activity by acetylation	10	2.42e-03	7.49e-03	0.643	0.4620	-0.4480	1.14e-02	1.43e-02
Defective GALNT3 causes HFTC	16	4.76e-05	2.44e-04	0.642	-0.6410	-0.0477	9.10e-06	7.41e-01
Nucleotide biosynthesis	14	1.64e-04	7.26e-04	0.642	0.0762	0.6370	6.22e-01	3.65e-05
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.22e-04	1.30e-03	0.641	0.0353	0.6400	8.26e-01	6.46e-05
Condensation of Prophase Chromosomes	13	3.35e-04	1.34e-03	0.638	0.0685	0.6350	6.69e-01	7.42e-05
Translocation of ZAP-70 to Immunological synapse	17	2.74e-05	1.55e-04	0.635	-0.2320	-0.5910	9.74e-02	2.43e-05
PRC2 methylates histones and DNA	14	1.95e-04	8.42e-04	0.635	0.1050	0.6260	4.96e-01	5.02e-05
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	1.09e-06	9.09e-06	0.628	0.1110	0.6180	3.58e-01	2.91e-07
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	1.09e-06	9.09e-06	0.628	0.1110	0.6180	3.58e-01	2.91e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	1.09e-06	9.09e-06	0.628	0.1110	0.6180	3.58e-01	2.91e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	1.09e-06	9.09e-06	0.628	0.1110	0.6180	3.58e-01	2.91e-07
Impaired BRCA2 binding to PALB2	23	1.09e-06	9.09e-06	0.628	0.1110	0.6180	3.58e-01	2.91e-07
Initial triggering of complement	19	1.03e-05	6.46e-05	0.625	-0.4460	-0.4380	7.58e-04	9.52e-04
Dectin-2 family	25	3.20e-07	3.11e-06	0.625	-0.5740	-0.2470	6.78e-07	3.28e-02
Lagging Strand Synthesis	20	7.67e-06	5.00e-05	0.623	0.1080	0.6140	4.02e-01	2.01e-06
Processing and activation of SUMO	10	2.73e-03	8.23e-03	0.619	0.3200	0.5300	7.95e-02	3.73e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	7.40e-07	6.59e-06	0.610	0.1100	0.6000	3.42e-01	2.03e-07
Processive synthesis on the lagging strand	15	2.10e-04	8.94e-04	0.609	0.1500	0.5900	3.16e-01	7.50e-05
cGMP effects	15	2.18e-04	9.28e-04	0.605	-0.5480	-0.2560	2.35e-04	8.67e-02
Postmitotic nuclear pore complex (NPC) reformation	26	7.25e-07	6.53e-06	0.603	-0.0305	0.6020	7.88e-01	1.06e-07
Keratinization	137	3.27e-32	6.15e-30	0.603	-0.2890	0.5290	5.13e-09	1.14e-26
Defective GALNT12 causes CRCS1	16	1.55e-04	6.96e-04	0.601	-0.5880	-0.1230	4.63e-05	3.93e-01
Homologous DNA Pairing and Strand Exchange	41	2.24e-10	4.61e-09	0.599	0.0887	0.5920	3.26e-01	5.35e-11
Transcriptional regulation of testis differentiation	12	1.33e-03	4.48e-03	0.598	0.4950	0.3360	2.98e-03	4.41e-02
Removal of the Flap Intermediate	14	5.23e-04	1.97e-03	0.596	0.1260	0.5830	4.15e-01	1.60e-04
Folding of actin by CCT/TriC	10	4.69e-03	1.28e-02	0.595	0.1050	0.5850	5.67e-01	1.35e-03
Presynaptic depolarization and calcium channel opening	12	1.71e-03	5.58e-03	0.594	-0.5920	-0.0400	3.82e-04	8.10e-01
Signaling by BMP	24	4.62e-06	3.25e-05	0.593	0.4470	-0.3890	1.48e-04	9.66e-04
Creation of C4 and C2 activators	12	1.50e-03	5.02e-03	0.592	-0.4260	-0.4110	1.06e-02	1.37e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	1.61e-09	2.85e-08	0.586	0.0769	0.5810	4.06e-01	3.36e-10

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.meth	s.rna	p.meth	p.rna
Unwinding of DNA	12	1.14e-07	1.25e-06	0.9440	-0.077000	0.941000	6.44e-01	1.64e-08
Defective pyroptosis	13	1.23e-06	1.02e-05	0.8310	0.154000	0.816000	3.36e-01	3.47e-07
Condensation of Prometaphase Chromosomes	11	3.56e-05	1.91e-04	0.7850	0.086000	0.780000	6.22e-01	7.39e-06
Endosomal/Vacuolar pathway	11	8.77e-05	4.17e-04	0.7630	0.621000	-0.443000	3.58e-04	1.10e-02
DNA strand elongation	32	3.96e-12	1.08e-10	0.7380	0.038900	0.737000	7.04e-01	5.14e-13
Activation of the pre-replicative complex	33	1.96e-12	5.68e-11	0.7350	0.079200	0.731000	4.31e-01	3.51e-13
Activation of ATR in response to replication stress	37	2.69e-13	8.99e-12	0.7190	0.097500	0.713000	3.05e-01	6.17e-14
Mucopolysaccharidoses	11	2.10e-04	8.94e-04	0.7140	-0.069800	-0.711000	6.89e-01	4.46e-05
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	4.49e-04	1.74e-03	0.7060	0.447000	0.547000	1.45e-02	2.73e-03
Digestion	11	2.81e-04	1.16e-03	0.7060	-0.702000	0.071800	5.50e-05	6.80e-01
SLBP independent Processing of Histone Pre-mRNAs	10	4.68e-04	1.80e-03	0.7060	0.338000	0.620000	6.41e-02	6.92e-04
Polo-like kinase mediated events	16	9.21e-06	5.87e-05	0.6970	-0.074700	0.693000	6.05e-01	1.58e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	3.05e-04	1.24e-03	0.6920	0.304000	0.622000	8.14e-02	3.54e-04
Deposition of new CENPA-containing nucleosomes at the centromere	25	1.48e-08	2.02e-07	0.6910	0.063000	0.689000	5.86e-01	2.50e-09
Nucleosome assembly	25	1.48e-08	2.02e-07	0.6910	0.063000	0.689000	5.86e-01	2.50e-09
Phosphorylation of CD3 and TCR zeta chains	20	7.37e-07	6.59e-06	0.6770	-0.321000	-0.596000	1.28e-02	3.88e-06
Response to metal ions	11	7.38e-04	2.69e-03	0.6630	0.660000	-0.053100	1.49e-04	7.61e-01
Purine ribonucleoside monophosphate biosynthesis	11	7.87e-04	2.82e-03	0.6550	0.108000	0.646000	5.35e-01	2.08e-04
G1/S-Specific Transcription	29	1.05e-08	1.50e-07	0.6480	0.048300	0.647000	6.53e-01	1.65e-09
Assembly of the ORC complex at the origin of replication	10	1.75e-03	5.67e-03	0.6470	0.116000	0.637000	5.25e-01	4.90e-04
Regulation of FOXO transcriptional activity by acetylation	10	2.42e-03	7.49e-03	0.6430	0.462000	-0.448000	1.14e-02	1.43e-02
Defective GALNT3 causes HFTC	16	4.76e-05	2.44e-04	0.6420	-0.641000	-0.047700	9.10e-06	7.41e-01
Nucleotide biosynthesis	14	1.64e-04	7.26e-04	0.6420	0.076200	0.637000	6.22e-01	3.65e-05
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.22e-04	1.30e-03	0.6410	0.035300	0.640000	8.26e-01	6.46e-05
Condensation of Prophase Chromosomes	13	3.35e-04	1.34e-03	0.6380	0.068500	0.635000	6.69e-01	7.42e-05
Translocation of ZAP-70 to Immunological synapse	17	2.74e-05	1.55e-04	0.6350	-0.232000	-0.591000	9.74e-02	2.43e-05
PRC2 methylates histones and DNA	14	1.95e-04	8.42e-04	0.6350	0.105000	0.626000	4.96e-01	5.02e-05
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	1.09e-06	9.09e-06	0.6280	0.111000	0.618000	3.58e-01	2.91e-07
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	1.09e-06	9.09e-06	0.6280	0.111000	0.618000	3.58e-01	2.91e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	1.09e-06	9.09e-06	0.6280	0.111000	0.618000	3.58e-01	2.91e-07
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	1.09e-06	9.09e-06	0.6280	0.111000	0.618000	3.58e-01	2.91e-07
Impaired BRCA2 binding to PALB2	23	1.09e-06	9.09e-06	0.6280	0.111000	0.618000	3.58e-01	2.91e-07
Initial triggering of complement	19	1.03e-05	6.46e-05	0.6250	-0.446000	-0.438000	7.58e-04	9.52e-04
Dectin-2 family	25	3.20e-07	3.11e-06	0.6250	-0.574000	-0.247000	6.78e-07	3.28e-02
Lagging Strand Synthesis	20	7.67e-06	5.00e-05	0.6230	0.108000	0.614000	4.02e-01	2.01e-06
Processing and activation of SUMO	10	2.73e-03	8.23e-03	0.6190	0.320000	0.530000	7.95e-02	3.73e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	7.40e-07	6.59e-06	0.6100	0.110000	0.600000	3.42e-01	2.03e-07
Processive synthesis on the lagging strand	15	2.10e-04	8.94e-04	0.6090	0.150000	0.590000	3.16e-01	7.50e-05
cGMP effects	15	2.18e-04	9.28e-04	0.6050	-0.548000	-0.256000	2.35e-04	8.67e-02
Postmitotic nuclear pore complex (NPC) reformation	26	7.25e-07	6.53e-06	0.6030	-0.030500	0.602000	7.88e-01	1.06e-07
Keratinization	137	3.27e-32	6.15e-30	0.6030	-0.289000	0.529000	5.13e-09	1.14e-26
Defective GALNT12 causes CRCS1	16	1.55e-04	6.96e-04	0.6010	-0.588000	-0.123000	4.63e-05	3.93e-01
Homologous DNA Pairing and Strand Exchange	41	2.24e-10	4.61e-09	0.5990	0.088700	0.592000	3.26e-01	5.35e-11
Transcriptional regulation of testis differentiation	12	1.33e-03	4.48e-03	0.5980	0.495000	0.336000	2.98e-03	4.41e-02
Removal of the Flap Intermediate	14	5.23e-04	1.97e-03	0.5960	0.126000	0.583000	4.15e-01	1.60e-04
Folding of actin by CCT/TriC	10	4.69e-03	1.28e-02	0.5950	0.105000	0.585000	5.67e-01	1.35e-03
Presynaptic depolarization and calcium channel opening	12	1.71e-03	5.58e-03	0.5940	-0.592000	-0.040000	3.82e-04	8.10e-01
Signaling by BMP	24	4.62e-06	3.25e-05	0.5930	0.447000	-0.389000	1.48e-04	9.66e-04
Creation of C4 and C2 activators	12	1.50e-03	5.02e-03	0.5920	-0.426000	-0.411000	1.06e-02	1.37e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	1.61e-09	2.85e-08	0.5860	0.076900	0.581000	4.06e-01	3.36e-10
Diseases of DNA Double-Strand Break Repair	39	1.61e-09	2.85e-08	0.5860	0.076900	0.581000	4.06e-01	3.36e-10
Interactions of Rev with host cellular proteins	35	1.59e-08	2.13e-07	0.5850	-0.018100	0.585000	8.53e-01	2.06e-09
Leading Strand Synthesis	14	7.41e-04	2.69e-03	0.5830	0.094600	0.575000	5.40e-01	1.94e-04
Polymerase switching	14	7.41e-04	2.69e-03	0.5830	0.094600	0.575000	5.40e-01	1.94e-04
Presynaptic phase of homologous DNA pairing and strand exchange	38	3.89e-09	6.30e-08	0.5810	0.083100	0.575000	3.75e-01	8.76e-10
Termination of O-glycan biosynthesis	23	8.50e-06	5.48e-05	0.5760	-0.533000	-0.217000	9.53e-06	7.17e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	30	3.13e-07	3.05e-06	0.5750	0.053000	0.573000	6.16e-01	5.56e-08
Impaired BRCA2 binding to RAD51	33	7.03e-08	8.08e-07	0.5740	0.092400	0.567000	3.59e-01	1.75e-08
Digestion and absorption	15	6.81e-04	2.50e-03	0.5740	-0.552000	0.155000	2.11e-04	3.00e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	6.47e-06	4.32e-05	0.5730	0.095700	0.565000	4.17e-01	1.63e-06
PCNA-Dependent Long Patch Base Excision Repair	21	2.96e-05	1.65e-04	0.5720	0.102000	0.563000	4.17e-01	7.91e-06
Activation of the TFAP2 (AP-2) family of transcription factors	11	4.07e-03	1.14e-02	0.5710	0.528000	0.219000	2.44e-03	2.09e-01
Rev-mediated nuclear export of HIV RNA	33	1.15e-07	1.25e-06	0.5690	-0.029400	0.568000	7.70e-01	1.58e-08
Erythrocytes take up carbon dioxide and release oxygen	12	3.22e-03	9.45e-03	0.5690	0.154000	-0.548000	3.55e-01	1.02e-03
O2/CO2 exchange in erythrocytes	12	3.22e-03	9.45e-03	0.5690	0.154000	-0.548000	3.55e-01	1.02e-03
Scavenging of heme from plasma	11	4.27e-03	1.18e-02	0.5670	-0.410000	-0.391000	1.85e-02	2.48e-02
Cyclin A/B1/B2 associated events during G2/M transition	24	9.65e-06	6.10e-05	0.5610	0.174000	0.534000	1.40e-01	5.98e-06
Resolution of D-Loop Structures	31	4.13e-07	3.88e-06	0.5610	0.035600	0.560000	7.32e-01	6.72e-08
Nuclear import of Rev protein	32	2.80e-07	2.76e-06	0.5610	0.004780	0.561000	9.63e-01	4.04e-08
PD-1 signaling	21	4.06e-05	2.14e-04	0.5600	-0.236000	-0.508000	6.09e-02	5.60e-05
ERKs are inactivated	13	2.78e-03	8.35e-03	0.5560	0.492000	-0.261000	2.15e-03	1.04e-01
G0 and Early G1	27	3.03e-06	2.26e-05	0.5560	0.138000	0.539000	2.15e-01	1.26e-06
Physiological factors	11	7.15e-03	1.86e-02	0.5560	0.398000	-0.387000	2.22e-02	2.62e-02
Regulation of gene expression by Hypoxia-inducible Factor	10	1.12e-02	2.69e-02	0.5550	0.465000	-0.302000	1.08e-02	9.82e-02
Sema4D induced cell migration and growth-cone collapse	20	1.36e-04	6.19e-04	0.5520	0.283000	-0.474000	2.85e-02	2.41e-04
The activation of arylsulfatases	10	9.96e-03	2.45e-02	0.5520	-0.070300	-0.548000	7.00e-01	2.71e-03
Keratan sulfate degradation	11	7.18e-03	1.86e-02	0.5520	0.175000	-0.523000	3.15e-01	2.64e-03
E2F mediated regulation of DNA replication	21	5.99e-05	2.96e-04	0.5500	0.178000	0.521000	1.57e-01	3.61e-05
SUMOylation of DNA replication proteins	44	1.84e-09	3.22e-08	0.5500	0.073500	0.545000	3.99e-01	3.91e-10
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	17	4.06e-04	1.59e-03	0.5470	0.222000	0.500000	1.14e-01	3.54e-04
Hyaluronan uptake and degradation	12	5.23e-03	1.41e-02	0.5460	0.218000	-0.501000	1.90e-01	2.68e-03
Meiotic recombination	25	1.40e-05	8.25e-05	0.5420	0.139000	0.524000	2.29e-01	5.80e-06
G2/M Checkpoints	129	1.54e-25	1.54e-23	0.5410	0.099400	0.532000	5.14e-02	1.53e-25
Adenylate cyclase activating pathway	10	1.09e-02	2.64e-02	0.5410	-0.442000	-0.311000	1.54e-02	8.81e-02
Metabolism of non-coding RNA	51	1.64e-10	3.47e-09	0.5410	0.081400	0.534000	3.15e-01	4.00e-11
snRNP Assembly	51	1.64e-10	3.47e-09	0.5410	0.081400	0.534000	3.15e-01	4.00e-11
Glucuronidation	18	4.71e-04	1.80e-03	0.5400	-0.280000	0.461000	3.96e-02	7.00e-04
NEP/NS2 Interacts with the Cellular Export Machinery	30	2.00e-06	1.58e-05	0.5390	0.018400	0.539000	8.62e-01	3.19e-07
Metabolism of Angiotensinogen to Angiotensins	17	5.03e-04	1.90e-03	0.5390	-0.261000	-0.472000	6.26e-02	7.62e-04
FCGR activation	12	4.80e-03	1.31e-02	0.5370	-0.283000	-0.457000	8.92e-02	6.17e-03
Defective C1GALT1C1 causes TNPS	17	6.28e-04	2.31e-03	0.5360	-0.535000	-0.043900	1.36e-04	7.54e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	2.52e-06	1.92e-05	0.5360	-0.007510	0.536000	9.43e-01	3.83e-07
Cell-extracellular matrix interactions	16	1.24e-03	4.22e-03	0.5350	0.287000	-0.452000	4.69e-02	1.74e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	4.70e-04	1.80e-03	0.5340	-0.050900	0.532000	7.09e-01	9.37e-05
Export of Viral Ribonucleoproteins from Nucleus	31	1.94e-06	1.54e-05	0.5300	0.048300	0.528000	6.41e-01	3.56e-07
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	3.42e-06	2.51e-05	0.5280	0.018200	0.528000	8.63e-01	5.53e-07
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	3.42e-06	2.51e-05	0.5280	0.018200	0.528000	8.63e-01	5.53e-07
Sema4D in semaphorin signaling	24	5.72e-05	2.84e-04	0.5280	0.271000	-0.453000	2.16e-02	1.21e-04
Interaction between L1 and Ankyrins	29	6.26e-06	4.24e-05	0.5270	-0.523000	0.060300	1.07e-06	5.74e-01
HDR through Single Strand Annealing (SSA)	36	2.78e-07	2.75e-06	0.5250	0.147000	0.504000	1.28e-01	1.68e-07
Signal regulatory protein family interactions	13	3.98e-03	1.13e-02	0.5250	-0.390000	-0.351000	1.49e-02	2.86e-02
Vpr-mediated nuclear import of PICs	32	2.19e-06	1.71e-05	0.5220	-0.031600	0.521000	7.57e-01	3.34e-07
Signaling by Leptin	10	1.83e-02	4.10e-02	0.5200	0.105000	-0.509000	5.64e-01	5.34e-03
Resolution of Sister Chromatid Cohesion	98	5.80e-18	3.23e-16	0.5180	0.070500	0.513000	2.28e-01	1.54e-18
DNA Replication	126	6.19e-23	4.90e-21	0.5180	0.112000	0.506000	3.03e-02	1.05e-22
Transport of organic anions	10	1.73e-02	3.90e-02	0.5150	-0.487000	-0.170000	7.72e-03	3.52e-01
Establishment of Sister Chromatid Cohesion	10	1.81e-02	4.06e-02	0.5150	0.084100	0.508000	6.45e-01	5.44e-03
Metabolism of nitric oxide: NOS3 activation and regulation	15	3.09e-03	9.16e-03	0.5150	0.359000	-0.368000	1.60e-02	1.35e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.20e-02	2.85e-02	0.5140	-0.135000	-0.496000	4.40e-01	4.40e-03
RHO GTPases Activate NADPH Oxidases	21	2.01e-04	8.60e-04	0.5130	-0.294000	-0.420000	1.96e-02	8.65e-04
G2/M DNA damage checkpoint	59	7.42e-11	1.72e-09	0.5120	0.047200	0.510000	5.31e-01	1.21e-11
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	86	1.74e-15	7.27e-14	0.5120	0.065600	0.508000	2.93e-01	3.91e-16
Amplification of signal from the kinetochores	86	1.74e-15	7.27e-14	0.5120	0.065600	0.508000	2.93e-01	3.91e-16
Transcription of E2F targets under negative control by DREAM complex	19	5.27e-04	1.98e-03	0.5110	0.106000	0.500000	4.23e-01	1.59e-04
Synthesis of DNA	118	7.15e-21	4.67e-19	0.5100	0.111000	0.497000	3.70e-02	1.01e-20
Orc1 removal from chromatin	68	2.25e-12	6.38e-11	0.5080	0.177000	0.476000	1.16e-02	1.09e-11
Formation of the cornified envelope	50	6.97e-09	1.04e-07	0.5070	-0.232000	0.451000	4.58e-03	3.48e-08
Processing of Capped Intronless Pre-mRNA	29	1.10e-05	6.71e-05	0.5070	0.208000	0.462000	5.28e-02	1.64e-05
HDR through MMEJ (alt-NHEJ)	11	1.35e-02	3.19e-02	0.5070	0.134000	0.489000	4.41e-01	5.01e-03
Activation of Ca-permeable Kainate Receptor	10	2.21e-02	4.78e-02	0.5050	-0.503000	0.045500	5.85e-03	8.03e-01
Ionotropic activity of kainate receptors	10	2.21e-02	4.78e-02	0.5050	-0.503000	0.045500	5.85e-03	8.03e-01
Transport of the SLBP Dependant Mature mRNA	34	2.44e-06	1.88e-05	0.5040	-0.014200	0.504000	8.86e-01	3.69e-07
MyD88 deficiency (TLR2/4)	17	1.37e-03	4.59e-03	0.5010	-0.341000	-0.367000	1.50e-02	8.75e-03
Transport of the SLBP independent Mature mRNA	33	4.42e-06	3.15e-05	0.5000	-0.013300	0.499000	8.95e-01	6.85e-07
Transport of Mature mRNAs Derived from Intronless Transcripts	41	2.41e-07	2.41e-06	0.4980	0.000947	0.498000	9.92e-01	3.43e-08
Diseases of DNA repair	49	1.06e-08	1.51e-07	0.4980	0.075300	0.492000	3.62e-01	2.52e-09
Cell Cycle Checkpoints	245	5.61e-40	1.69e-37	0.4960	0.076300	0.490000	4.00e-02	7.00e-40
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	2.71e-03	8.19e-03	0.4950	0.032800	0.494000	8.20e-01	6.21e-04
Transport of Mature mRNA Derived from an Intronless Transcript	40	4.35e-07	4.07e-06	0.4940	0.002050	0.494000	9.82e-01	6.33e-08
Class C/3 (Metabotropic glutamate/pheromone receptors)	26	9.67e-05	4.53e-04	0.4930	-0.446000	0.209000	8.20e-05	6.54e-02
Initiation of Nuclear Envelope (NE) Reformation	19	8.68e-04	3.06e-03	0.4920	0.185000	0.456000	1.63e-01	5.78e-04
Bicarbonate transporters	10	2.46e-02	5.23e-02	0.4900	-0.423000	-0.249000	2.06e-02	1.74e-01
Generation of second messenger molecules	32	7.84e-06	5.08e-05	0.4880	-0.268000	-0.408000	8.73e-03	6.41e-05
Sodium/Calcium exchangers	11	1.75e-02	3.94e-02	0.4880	-0.374000	-0.314000	3.17e-02	7.17e-02
rRNA modification in the nucleus and cytosol	56	2.33e-09	3.98e-08	0.4880	-0.029700	0.487000	7.01e-01	2.93e-10
Chromosome Maintenance	88	2.04e-14	7.69e-13	0.4860	0.128000	0.469000	3.86e-02	2.98e-14
DNA Replication Pre-Initiation	100	3.57e-16	1.68e-14	0.4850	0.092700	0.476000	1.10e-01	1.90e-16
Presynaptic nicotinic acetylcholine receptors	11	2.33e-02	5.00e-02	0.4840	-0.275000	0.399000	1.14e-01	2.21e-02
Antimicrobial peptides	39	1.13e-06	9.40e-06	0.4840	-0.484000	-0.001560	1.69e-07	9.87e-01
SUMOylation of transcription factors	20	7.46e-04	2.70e-03	0.4830	0.366000	0.315000	4.65e-03	1.47e-02
tRNA processing in the nucleus	54	5.01e-09	7.85e-08	0.4830	0.114000	0.469000	1.47e-01	2.48e-09
Interactions of Vpr with host cellular proteins	34	7.29e-06	4.81e-05	0.4820	-0.017600	0.482000	8.59e-01	1.15e-06
Mitotic Telophase/Cytokinesis	12	1.52e-02	3.51e-02	0.4810	0.044800	0.479000	7.88e-01	4.09e-03
Rap1 signalling	15	6.41e-03	1.69e-02	0.4810	0.286000	-0.386000	5.49e-02	9.63e-03
Acetylcholine binding and downstream events	12	1.72e-02	3.90e-02	0.4800	-0.195000	0.439000	2.43e-01	8.45e-03
Postsynaptic nicotinic acetylcholine receptors	12	1.72e-02	3.90e-02	0.4800	-0.195000	0.439000	2.43e-01	8.45e-03
SUMOylation of SUMOylation proteins	33	1.07e-05	6.60e-05	0.4800	0.040500	0.478000	6.87e-01	2.00e-06
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	14	7.28e-03	1.89e-02	0.4790	-0.436000	-0.198000	4.74e-03	2.00e-01
Defective EXT2 causes exostoses 2	14	7.28e-03	1.89e-02	0.4790	-0.436000	-0.198000	4.74e-03	2.00e-01
Processing of DNA double-strand break ends	62	4.75e-10	9.66e-09	0.4780	0.098500	0.468000	1.80e-01	1.89e-10
G1/S Transition	129	4.65e-20	2.91e-18	0.4770	0.120000	0.462000	1.82e-02	1.32e-19
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	7.84e-03	2.01e-02	0.4770	0.129000	0.459000	4.05e-01	2.94e-03
Nitric oxide stimulates guanylate cyclase	22	4.71e-04	1.80e-03	0.4760	-0.420000	-0.223000	6.42e-04	7.00e-02
Aspirin ADME	34	1.26e-05	7.49e-05	0.4760	-0.438000	0.186000	1.00e-05	5.99e-02
Telomere C-strand (Lagging Strand) Synthesis	33	1.34e-05	7.90e-05	0.4730	0.105000	0.461000	2.97e-01	4.49e-06
PKA activation	17	2.90e-03	8.64e-03	0.4720	-0.264000	-0.391000	5.93e-02	5.22e-03
FCERI mediated Ca+2 mobilization	28	6.55e-05	3.19e-04	0.4720	-0.334000	-0.333000	2.20e-03	2.29e-03
IRAK4 deficiency (TLR2/4)	18	2.06e-03	6.51e-03	0.4720	-0.344000	-0.323000	1.16e-02	1.77e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	11	2.36e-02	5.04e-02	0.4700	0.336000	0.328000	5.39e-02	5.93e-02
Regulation of TLR by endogenous ligand	17	3.18e-03	9.41e-03	0.4690	-0.426000	-0.197000	2.35e-03	1.59e-01
Organic cation/anion/zwitterion transport	11	2.40e-02	5.13e-02	0.4690	-0.408000	-0.231000	1.90e-02	1.84e-01
HDR through Homologous Recombination (HRR)	64	7.19e-10	1.38e-08	0.4670	0.057800	0.463000	4.24e-01	1.43e-10
RHO GTPases Activate ROCKs	19	2.55e-03	7.78e-03	0.4650	0.356000	-0.298000	7.19e-03	2.44e-02
Other semaphorin interactions	19	1.79e-03	5.76e-03	0.4640	-0.295000	-0.359000	2.61e-02	6.78e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	30	5.05e-05	2.57e-04	0.4630	-0.415000	-0.206000	8.36e-05	5.04e-02
EML4 and NUDC in mitotic spindle formation	90	3.02e-13	9.87e-12	0.4610	0.068400	0.456000	2.63e-01	7.85e-14
mRNA decay by 3’ to 5’ exoribonuclease	16	5.54e-03	1.48e-02	0.4610	0.170000	0.428000	2.38e-01	3.05e-03
Mitotic Spindle Checkpoint	103	5.73e-15	2.27e-13	0.4600	0.040500	0.459000	4.78e-01	8.81e-16
Regulation of FZD by ubiquitination	21	1.54e-03	5.13e-03	0.4600	0.358000	-0.289000	4.46e-03	2.21e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	1.11e-02	2.67e-02	0.4590	-0.132000	-0.440000	3.93e-01	4.39e-03
Formation of tubulin folding intermediates by CCT/TriC	23	7.62e-04	2.76e-03	0.4590	-0.081200	0.451000	5.00e-01	1.79e-04
CLEC7A (Dectin-1) induces NFAT activation	11	2.82e-02	5.90e-02	0.4590	-0.255000	-0.381000	1.43e-01	2.86e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	1.45e-07	1.54e-06	0.4580	0.171000	0.425000	3.85e-02	2.60e-07
p53-Independent DNA Damage Response	49	1.45e-07	1.54e-06	0.4580	0.171000	0.425000	3.85e-02	2.60e-07
p53-Independent G1/S DNA damage checkpoint	49	1.45e-07	1.54e-06	0.4580	0.171000	0.425000	3.85e-02	2.60e-07
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.20e-02	2.86e-02	0.4570	0.074200	0.451000	6.31e-01	3.52e-03
Biotin transport and metabolism	11	3.33e-02	6.79e-02	0.4560	-0.453000	0.051100	9.33e-03	7.69e-01
FCGR3A-mediated IL10 synthesis	37	7.24e-06	4.80e-05	0.4550	-0.305000	-0.338000	1.35e-03	3.69e-04
Viral Messenger RNA Synthesis	42	1.90e-06	1.51e-05	0.4550	0.096200	0.444000	2.81e-01	6.22e-07
Homology Directed Repair	100	2.90e-14	1.06e-12	0.4540	0.087600	0.446000	1.30e-01	1.36e-14
Switching of origins to a post-replicative state	89	8.30e-13	2.60e-11	0.4540	0.125000	0.436000	4.17e-02	1.16e-12
Separation of Sister Chromatids	160	4.14e-22	2.96e-20	0.4520	0.084000	0.444000	6.69e-02	3.26e-22
FOXO-mediated transcription of cell cycle genes	17	6.50e-03	1.71e-02	0.4510	0.360000	-0.271000	1.01e-02	5.30e-02
Processive synthesis on the C-strand of the telomere	19	2.70e-03	8.18e-03	0.4510	0.178000	0.414000	1.80e-01	1.78e-03
eNOS activation	11	3.93e-02	7.79e-02	0.4490	0.275000	-0.355000	1.14e-01	4.13e-02
Regulation of gene expression in beta cells	18	3.76e-03	1.07e-02	0.4490	0.232000	0.384000	8.89e-02	4.74e-03
Transcriptional Regulation by E2F6	33	4.12e-05	2.16e-04	0.4480	0.118000	0.433000	2.42e-01	1.70e-05
tRNA processing	100	6.19e-14	2.17e-12	0.4480	0.091300	0.439000	1.15e-01	3.28e-14
Olfactory Signaling Pathway	68	1.96e-09	3.39e-08	0.4480	-0.421000	0.153000	1.91e-09	2.87e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	57	3.05e-08	3.76e-07	0.4480	0.085200	0.440000	2.66e-01	9.42e-09
HS-GAG degradation	21	1.56e-03	5.15e-03	0.4470	-0.239000	-0.378000	5.79e-02	2.74e-03
FGFR2 alternative splicing	26	3.36e-04	1.34e-03	0.4470	0.244000	0.374000	3.13e-02	9.55e-04
mRNA decay by 5’ to 3’ exoribonuclease	15	9.78e-03	2.42e-02	0.4470	0.310000	0.321000	3.74e-02	3.12e-02
Assembly of the pre-replicative complex	83	1.44e-11	3.74e-10	0.4460	0.088200	0.437000	1.65e-01	5.87e-12
S Phase	159	1.91e-21	1.31e-19	0.4460	0.097100	0.435000	3.48e-02	2.85e-21
Expression and translocation of olfactory receptors	62	1.57e-08	2.12e-07	0.4450	-0.411000	0.170000	2.15e-08	2.10e-02
MAPK3 (ERK1) activation	10	5.63e-02	1.05e-01	0.4450	0.304000	-0.325000	9.62e-02	7.55e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	52	1.48e-07	1.56e-06	0.4440	0.185000	0.404000	2.13e-02	4.63e-07
Acyl chain remodelling of PI	14	1.49e-02	3.46e-02	0.4440	-0.429000	-0.115000	5.45e-03	4.56e-01
Diseases of programmed cell death	43	2.22e-06	1.73e-05	0.4440	0.208000	0.392000	1.82e-02	8.63e-06
Carnitine metabolism	11	4.26e-02	8.37e-02	0.4440	0.275000	-0.349000	1.15e-01	4.52e-02
Glutathione synthesis and recycling	12	3.22e-02	6.59e-02	0.4440	-0.321000	0.306000	5.42e-02	6.63e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	7.34e-13	2.35e-11	0.4440	0.077100	0.437000	1.97e-01	2.47e-13
Nuclear Pore Complex (NPC) Disassembly	34	4.33e-05	2.26e-04	0.4430	0.019900	0.443000	8.41e-01	7.81e-06
KSRP (KHSRP) binds and destabilizes mRNA	17	5.89e-03	1.56e-02	0.4430	0.231000	0.378000	9.90e-02	7.01e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.02e-02	2.50e-02	0.4430	0.211000	-0.389000	1.43e-01	7.06e-03
RNA Polymerase I Promoter Escape	27	3.16e-04	1.27e-03	0.4430	0.122000	0.426000	2.73e-01	1.29e-04
Transcriptional regulation by small RNAs	46	1.24e-06	1.02e-05	0.4420	0.084900	0.433000	3.19e-01	3.65e-07
Mitochondrial translation elongation	82	2.57e-11	6.34e-10	0.4410	0.192000	0.396000	2.61e-03	5.43e-10
O-linked glycosylation of mucins	57	5.27e-08	6.29e-07	0.4400	-0.428000	-0.103000	2.31e-08	1.78e-01
NS1 Mediated Effects on Host Pathways	39	1.22e-05	7.33e-05	0.4390	0.016800	0.439000	8.56e-01	2.08e-06
Acyl chain remodelling of PC	23	1.10e-03	3.75e-03	0.4390	-0.395000	-0.193000	1.04e-03	1.10e-01
Major pathway of rRNA processing in the nucleolus and cytosol	173	1.71e-22	1.29e-20	0.4390	0.062600	0.435000	1.56e-01	6.02e-23
RNA Polymerase II Transcription Termination	65	4.56e-09	7.29e-08	0.4380	0.229000	0.374000	1.44e-03	1.83e-07
Mitochondrial translation termination	82	3.60e-11	8.60e-10	0.4370	0.199000	0.390000	1.88e-03	1.05e-09
rRNA processing	189	2.84e-24	2.67e-22	0.4370	0.061200	0.433000	1.47e-01	1.03e-24
Collagen chain trimerization	43	6.30e-06	4.25e-05	0.4370	-0.370000	0.232000	2.66e-05	8.42e-03
rRNA processing in the nucleus and cytosol	183	1.96e-23	1.74e-21	0.4360	0.052200	0.433000	2.24e-01	4.90e-24
Translesion Synthesis by POLH	19	4.04e-03	1.13e-02	0.4360	0.117000	0.420000	3.78e-01	1.51e-03
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	116	1.93e-15	7.84e-14	0.4360	-0.235000	-0.368000	1.24e-05	8.09e-12
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	11	4.04e-02	8.00e-02	0.4340	0.296000	0.318000	8.95e-02	6.76e-02
Mitotic Metaphase and Anaphase	219	1.27e-27	1.74e-25	0.4340	0.070100	0.428000	7.43e-02	8.73e-28
Elevation of cytosolic Ca2+ levels	15	1.40e-02	3.28e-02	0.4340	-0.068200	-0.428000	6.48e-01	4.08e-03
SCF(Skp2)-mediated degradation of p27/p21	59	4.03e-08	4.89e-07	0.4340	0.203000	0.383000	7.07e-03	3.54e-07
Mitochondrial translation	88	1.14e-11	3.02e-10	0.4330	0.175000	0.396000	4.49e-03	1.41e-10
Mitotic Anaphase	218	3.17e-27	3.67e-25	0.4320	0.071700	0.426000	6.87e-02	2.35e-27
Complement cascade	50	5.77e-07	5.29e-06	0.4320	-0.305000	-0.305000	1.87e-04	1.93e-04
Mitotic G1 phase and G1/S transition	147	9.74e-19	5.86e-17	0.4310	0.120000	0.415000	1.22e-02	4.13e-18
Mismatch Repair	15	1.46e-02	3.40e-02	0.4310	0.082200	0.423000	5.82e-01	4.57e-03
Extension of Telomeres	50	7.47e-07	6.61e-06	0.4310	0.111000	0.416000	1.74e-01	3.55e-07
Phase 0 - rapid depolarisation	31	1.79e-04	7.81e-04	0.4300	-0.427000	-0.047700	3.90e-05	6.46e-01
Resolution of Abasic Sites (AP sites)	37	3.10e-05	1.68e-04	0.4290	0.144000	0.404000	1.31e-01	2.13e-05
Surfactant metabolism	26	9.31e-04	3.26e-03	0.4280	0.168000	-0.393000	1.38e-01	5.17e-04
PKA activation in glucagon signalling	16	1.11e-02	2.67e-02	0.4270	-0.242000	-0.352000	9.42e-02	1.47e-02
RAF-independent MAPK1/3 activation	23	2.29e-03	7.12e-03	0.4260	0.342000	-0.254000	4.52e-03	3.50e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	74	1.56e-09	2.82e-08	0.4260	0.071100	0.420000	2.91e-01	4.22e-10
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	3.52e-02	7.10e-02	0.4260	0.205000	0.373000	2.18e-01	2.53e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	1.50e-02	3.47e-02	0.4260	-0.317000	-0.284000	3.33e-02	5.72e-02
Translesion synthesis by REV1	16	1.18e-02	2.82e-02	0.4260	0.160000	0.395000	2.69e-01	6.29e-03
G1/S DNA Damage Checkpoints	65	1.63e-08	2.18e-07	0.4250	0.172000	0.388000	1.66e-02	6.21e-08
Mitochondrial translation initiation	82	1.57e-10	3.43e-09	0.4240	0.180000	0.384000	4.97e-03	1.80e-09
Transport of Mature Transcript to Cytoplasm	78	6.14e-10	1.21e-08	0.4230	0.131000	0.402000	4.59e-02	8.45e-10
Interleukin-37 signaling	19	5.58e-03	1.49e-02	0.4210	-0.204000	-0.369000	1.23e-01	5.42e-03
Acyl chain remodelling of PS	18	7.42e-03	1.91e-02	0.4210	-0.379000	-0.185000	5.42e-03	1.75e-01
APC/C-mediated degradation of cell cycle proteins	85	1.25e-10	2.77e-09	0.4210	0.077700	0.414000	2.16e-01	4.18e-11
Regulation of mitotic cell cycle	85	1.25e-10	2.77e-09	0.4210	0.077700	0.414000	2.16e-01	4.18e-11
SUMOylation of ubiquitinylation proteins	37	5.26e-05	2.67e-04	0.4210	0.027400	0.420000	7.73e-01	9.91e-06
Telomere Maintenance	65	2.39e-08	2.99e-07	0.4210	0.148000	0.394000	3.93e-02	4.04e-08
APC/C:Cdc20 mediated degradation of mitotic proteins	73	3.34e-09	5.65e-08	0.4200	0.082300	0.412000	2.24e-01	1.14e-09
Transcriptional regulation of pluripotent stem cells	26	1.03e-03	3.58e-03	0.4200	0.420000	0.003000	2.10e-04	9.79e-01
ERBB2 Activates PTK6 Signaling	13	2.90e-02	6.04e-02	0.4200	-0.281000	-0.312000	7.99e-02	5.11e-02
ABC transporters in lipid homeostasis	17	9.78e-03	2.42e-02	0.4200	-0.321000	-0.271000	2.19e-02	5.35e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	47	3.32e-06	2.46e-05	0.4190	0.157000	0.388000	6.23e-02	4.11e-06
VLDLR internalisation and degradation	16	1.63e-02	3.73e-02	0.4180	0.390000	-0.152000	6.91e-03	2.94e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	2.20e-02	4.78e-02	0.4180	0.328000	-0.260000	2.80e-02	8.18e-02
Base Excision Repair	45	6.24e-06	4.24e-05	0.4180	0.145000	0.392000	9.24e-02	5.51e-06
Processing of Intronless Pre-mRNAs	20	4.86e-03	1.32e-02	0.4170	0.144000	0.392000	2.66e-01	2.41e-03
Regulation of ornithine decarboxylase (ODC)	48	2.82e-06	2.13e-05	0.4170	0.162000	0.385000	5.27e-02	4.05e-06
RNA Polymerase I Transcription Initiation	42	1.45e-05	8.51e-05	0.4160	0.155000	0.387000	8.25e-02	1.46e-05
GPVI-mediated activation cascade	32	1.97e-04	8.47e-04	0.4160	-0.210000	-0.359000	3.96e-02	4.35e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript	69	1.24e-08	1.73e-07	0.4160	0.147000	0.389000	3.50e-02	2.32e-08
Stabilization of p53	54	6.19e-07	5.65e-06	0.4160	0.177000	0.376000	2.43e-02	1.77e-06
Autodegradation of the E3 ubiquitin ligase COP1	49	2.40e-06	1.86e-05	0.4150	0.163000	0.382000	4.82e-02	3.73e-06
Role of phospholipids in phagocytosis	23	2.23e-03	6.97e-03	0.4150	-0.249000	-0.332000	3.86e-02	5.90e-03
Vif-mediated degradation of APOBEC3G	49	2.51e-06	1.92e-05	0.4140	0.186000	0.370000	2.44e-02	7.40e-06
Uptake and function of anthrax toxins	11	5.72e-02	1.07e-01	0.4130	-0.120000	-0.395000	4.90e-01	2.33e-02
SCF-beta-TrCP mediated degradation of Emi1	52	1.37e-06	1.11e-05	0.4120	0.139000	0.388000	8.40e-02	1.26e-06
SUMOylation of RNA binding proteins	45	1.05e-05	6.53e-05	0.4120	0.004440	0.412000	9.59e-01	1.72e-06
EPHA-mediated growth cone collapse	15	2.36e-02	5.04e-02	0.4120	0.140000	-0.388000	3.47e-01	9.36e-03
Eicosanoid ligand-binding receptors	14	3.14e-02	6.46e-02	0.4120	0.316000	-0.265000	4.09e-02	8.62e-02
Positive epigenetic regulation of rRNA expression	44	1.06e-05	6.53e-05	0.4110	0.251000	0.325000	3.94e-03	1.90e-04
p53-Dependent G1 DNA Damage Response	63	8.63e-08	9.68e-07	0.4100	0.180000	0.369000	1.37e-02	4.06e-07
p53-Dependent G1/S DNA damage checkpoint	63	8.63e-08	9.68e-07	0.4100	0.180000	0.369000	1.37e-02	4.06e-07
NCAM1 interactions	34	1.91e-04	8.34e-04	0.4100	-0.410000	-0.004550	3.56e-05	9.63e-01
Activation of HOX genes during differentiation	60	2.07e-07	2.10e-06	0.4090	0.360000	0.194000	1.42e-06	9.44e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis	60	2.07e-07	2.10e-06	0.4090	0.360000	0.194000	1.42e-06	9.44e-03
Metabolism of polyamines	55	8.23e-07	7.24e-06	0.4090	0.137000	0.385000	7.84e-02	7.94e-07
ERK/MAPK targets	22	4.83e-03	1.31e-02	0.4080	0.268000	-0.308000	2.95e-02	1.25e-02
Ubiquitin-dependent degradation of Cyclin D	49	3.86e-06	2.79e-05	0.4080	0.167000	0.372000	4.31e-02	6.74e-06
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	71	1.79e-08	2.34e-07	0.4070	0.095200	0.396000	1.66e-01	8.16e-09
RNA Polymerase I Promoter Clearance	46	9.27e-06	5.88e-05	0.4060	0.149000	0.378000	8.10e-02	9.33e-06
Regulation of APC/C activators between G1/S and early anaphase	78	3.57e-09	5.96e-08	0.4060	0.080500	0.398000	2.19e-01	1.24e-09
N-glycan antennae elongation in the medial/trans-Golgi	24	2.84e-03	8.49e-03	0.4050	-0.403000	0.034000	6.27e-04	7.73e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	14	3.02e-02	6.23e-02	0.4050	-0.383000	-0.130000	1.31e-02	3.99e-01
NGF-stimulated transcription	40	6.75e-05	3.27e-04	0.4040	0.385000	-0.121000	2.50e-05	1.84e-01
Beta-oxidation of very long chain fatty acids	10	9.06e-02	1.56e-01	0.4040	0.122000	-0.385000	5.03e-01	3.52e-02
Influenza Viral RNA Transcription and Replication	131	1.50e-14	5.78e-13	0.4030	0.034600	0.401000	4.95e-01	2.27e-15
mRNA Splicing - Minor Pathway	49	5.36e-06	3.70e-05	0.4020	0.187000	0.355000	2.35e-02	1.68e-05
Interleukin-6 signaling	11	7.48e-02	1.34e-01	0.4020	0.202000	-0.347000	2.46e-01	4.61e-02
Spry regulation of FGF signaling	16	2.34e-02	5.02e-02	0.4010	0.253000	-0.312000	8.00e-02	3.08e-02
Ethanol oxidation	12	6.01e-02	1.11e-01	0.4010	0.300000	-0.267000	7.24e-02	1.09e-01
PKA-mediated phosphorylation of CREB	19	8.96e-03	2.24e-02	0.4010	-0.243000	-0.319000	6.70e-02	1.60e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	70	3.98e-08	4.86e-07	0.4000	0.102000	0.387000	1.39e-01	2.14e-08
PI3K events in ERBB4 signaling	10	8.42e-02	1.47e-01	0.4000	-0.237000	-0.323000	1.95e-01	7.69e-02
Regulation of Complement cascade	41	4.00e-05	2.12e-04	0.4000	-0.278000	-0.287000	2.04e-03	1.46e-03
tRNA Aminoacylation	24	3.23e-03	9.46e-03	0.3990	0.006710	0.399000	9.55e-01	7.16e-04
MET receptor recycling	10	9.64e-02	1.63e-01	0.3980	0.123000	-0.379000	5.02e-01	3.80e-02
Removal of the Flap Intermediate from the C-strand	17	1.62e-02	3.72e-02	0.3980	0.162000	0.363000	2.47e-01	9.55e-03
DNA Double-Strand Break Repair	129	4.06e-14	1.45e-12	0.3980	0.091100	0.387000	7.42e-02	3.21e-14
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	3.55e-02	7.11e-02	0.3970	0.066800	0.391000	6.65e-01	1.13e-02
Fanconi Anemia Pathway	32	5.44e-04	2.04e-03	0.3960	-0.014300	0.396000	8.89e-01	1.06e-04
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	51	4.57e-06	3.24e-05	0.3960	0.194000	0.345000	1.66e-02	1.98e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	3.81e-06	2.76e-05	0.3960	0.155000	0.365000	5.39e-02	5.41e-06
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.65e-02	3.76e-02	0.3950	0.293000	0.265000	3.65e-02	5.82e-02
SARS-CoV-2 modulates host translation machinery	48	1.24e-05	7.39e-05	0.3950	0.043100	0.393000	6.05e-01	2.50e-06
mRNA Capping	27	1.58e-03	5.22e-03	0.3950	0.162000	0.360000	1.45e-01	1.21e-03
Cap-dependent Translation Initiation	116	1.79e-12	5.28e-11	0.3950	0.018100	0.394000	7.36e-01	2.24e-13
Eukaryotic Translation Initiation	116	1.79e-12	5.28e-11	0.3950	0.018100	0.394000	7.36e-01	2.24e-13
mRNA 3’-end processing	56	1.53e-06	1.23e-05	0.3940	0.209000	0.335000	6.89e-03	1.49e-05
Recognition of DNA damage by PCNA-containing replication complex	30	7.97e-04	2.85e-03	0.3940	0.155000	0.362000	1.43e-01	5.92e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	71	5.95e-08	6.99e-07	0.3930	0.087100	0.383000	2.04e-01	2.32e-08
CDK-mediated phosphorylation and removal of Cdc6	70	6.90e-08	7.98e-07	0.3930	0.130000	0.371000	6.03e-02	7.99e-08
Nuclear Events (kinase and transcription factor activation)	62	8.89e-07	7.77e-06	0.3930	0.337000	-0.202000	4.53e-06	5.95e-03
Translation	264	2.98e-27	3.67e-25	0.3930	0.078900	0.385000	2.77e-02	5.43e-27
Phase 4 - resting membrane potential	18	1.57e-02	3.61e-02	0.3920	0.020800	0.391000	8.78e-01	4.06e-03
Regulation of Apoptosis	50	8.55e-06	5.49e-05	0.3910	0.137000	0.366000	9.34e-02	7.55e-06
ROS and RNS production in phagocytes	35	2.68e-04	1.11e-03	0.3910	-0.204000	-0.333000	3.65e-02	6.48e-04
NoRC negatively regulates rRNA expression	42	5.41e-05	2.72e-04	0.3900	0.178000	0.347000	4.54e-02	9.91e-05
SRP-dependent cotranslational protein targeting to membrane	108	1.82e-11	4.63e-10	0.3900	0.043300	0.388000	4.37e-01	3.32e-12
p130Cas linkage to MAPK signaling for integrins	15	2.96e-02	6.16e-02	0.3900	-0.210000	-0.329000	1.59e-01	2.75e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	33	4.41e-04	1.72e-03	0.3900	0.200000	0.335000	4.63e-02	8.78e-04
Influenza Infection	150	1.45e-15	6.59e-14	0.3890	0.050700	0.386000	2.85e-01	3.32e-16
Caspase activation via Dependence Receptors in the absence of ligand	10	1.07e-01	1.77e-01	0.3890	0.112000	-0.373000	5.40e-01	4.12e-02
RNA Polymerase I Transcription	47	1.84e-05	1.05e-04	0.3890	0.166000	0.352000	4.85e-02	3.04e-05
HIV Transcription Initiation	45	3.11e-05	1.68e-04	0.3890	0.123000	0.369000	1.52e-01	1.87e-05
RNA Polymerase II HIV Promoter Escape	45	3.11e-05	1.68e-04	0.3890	0.123000	0.369000	1.52e-01	1.87e-05
RNA Polymerase II Promoter Escape	45	3.11e-05	1.68e-04	0.3890	0.123000	0.369000	1.52e-01	1.87e-05
RNA Polymerase II Transcription Initiation	45	3.11e-05	1.68e-04	0.3890	0.123000	0.369000	1.52e-01	1.87e-05
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	3.11e-05	1.68e-04	0.3890	0.123000	0.369000	1.52e-01	1.87e-05
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	3.11e-05	1.68e-04	0.3890	0.123000	0.369000	1.52e-01	1.87e-05
Pyrimidine catabolism	11	8.38e-02	1.47e-01	0.3890	-0.387000	0.036600	2.63e-02	8.34e-01
Signaling by WNT in cancer	33	6.72e-04	2.47e-03	0.3890	0.357000	-0.154000	3.91e-04	1.25e-01
Degradation of DVL	54	3.97e-06	2.86e-05	0.3890	0.129000	0.366000	1.01e-01	3.19e-06
Pexophagy	11	8.96e-02	1.55e-01	0.3880	0.301000	-0.245000	8.36e-02	1.60e-01
Beta-catenin phosphorylation cascade	17	2.26e-02	4.89e-02	0.3880	0.378000	-0.086200	6.93e-03	5.38e-01
STAT5 activation downstream of FLT3 ITD mutants	10	1.10e-01	1.80e-01	0.3880	0.137000	-0.363000	4.52e-01	4.71e-02
ERBB2 Regulates Cell Motility	15	3.15e-02	6.48e-02	0.3870	-0.166000	-0.350000	2.66e-01	1.89e-02
Acyl chain remodelling of PE	21	7.93e-03	2.03e-02	0.3870	-0.351000	-0.164000	5.36e-03	1.94e-01
L13a-mediated translational silencing of Ceruloplasmin expression	108	3.38e-11	8.20e-10	0.3860	0.014300	0.386000	7.98e-01	4.25e-12
Polymerase switching on the C-strand of the telomere	25	3.53e-03	1.01e-02	0.3860	0.081000	0.377000	4.83e-01	1.10e-03
Negative regulation of MET activity	21	8.71e-03	2.19e-02	0.3860	-0.083600	-0.376000	5.07e-01	2.82e-03
mRNA Splicing - Major Pathway	174	7.63e-18	4.10e-16	0.3860	0.168000	0.347000	1.35e-04	2.93e-15
Vpu mediated degradation of CD4	49	1.49e-05	8.70e-05	0.3850	0.142000	0.358000	8.51e-02	1.46e-05
Nuclear Envelope (NE) Reassembly	71	1.57e-07	1.64e-06	0.3840	0.016400	0.383000	8.11e-01	2.36e-08
Activation of Matrix Metalloproteinases	30	1.63e-03	5.36e-03	0.3830	-0.250000	0.291000	1.79e-02	5.80e-03
Processing of Capped Intron-Containing Pre-mRNA	231	4.10e-23	3.43e-21	0.3830	0.155000	0.351000	5.23e-05	4.23e-20
CD28 dependent Vav1 pathway	12	6.74e-02	1.23e-01	0.3830	-0.350000	-0.156000	3.60e-02	3.50e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	1.04e-01	1.74e-01	0.3820	-0.251000	-0.288000	1.69e-01	1.14e-01
Epigenetic regulation of gene expression	83	8.50e-09	1.24e-07	0.3820	0.189000	0.332000	2.92e-03	1.72e-07
tRNA modification in the nucleus and cytosol	40	1.53e-04	6.93e-04	0.3810	0.048700	0.378000	5.94e-01	3.48e-05
Hh mutants are degraded by ERAD	53	7.41e-06	4.85e-05	0.3810	0.194000	0.328000	1.48e-02	3.64e-05
Gap-filling DNA repair synthesis and ligation in GG-NER	25	3.93e-03	1.12e-02	0.3800	0.142000	0.353000	2.20e-01	2.25e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	109	6.45e-11	1.52e-09	0.3790	0.014400	0.379000	7.95e-01	8.22e-12
Metabolism of RNA	639	7.66e-60	1.15e-56	0.3790	0.124000	0.358000	1.10e-07	8.78e-54
PLC beta mediated events	47	2.98e-05	1.66e-04	0.3790	-0.262000	-0.274000	1.87e-03	1.17e-03
N-Glycan antennae elongation	14	5.05e-02	9.74e-02	0.3790	-0.374000	0.059000	1.53e-02	7.02e-01
Formation of a pool of free 40S subunits	98	7.26e-10	1.38e-08	0.3780	0.025900	0.377000	6.58e-01	1.07e-10
RMTs methylate histone arginines	31	1.08e-03	3.72e-03	0.3780	0.238000	0.293000	2.19e-02	4.69e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	30	1.59e-03	5.23e-03	0.3780	0.032900	0.376000	7.55e-01	3.63e-04
Effects of PIP2 hydrolysis	27	2.80e-03	8.42e-03	0.3770	-0.147000	-0.347000	1.86e-01	1.80e-03
Cell Cycle, Mitotic	479	2.30e-44	1.15e-41	0.3770	0.056500	0.372000	3.49e-02	3.33e-44
RNA Pol II CTD phosphorylation and interaction with CE	25	4.34e-03	1.20e-02	0.3760	0.167000	0.337000	1.47e-01	3.52e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	25	4.34e-03	1.20e-02	0.3760	0.167000	0.337000	1.47e-01	3.52e-03
Peroxisomal lipid metabolism	27	3.32e-03	9.58e-03	0.3750	-0.016500	-0.375000	8.82e-01	7.54e-04
Meiosis	54	9.89e-06	6.22e-05	0.3750	0.104000	0.360000	1.85e-01	4.83e-06
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	5.19e-06	3.61e-05	0.3750	-0.004330	0.375000	9.55e-01	8.11e-07
Prefoldin mediated transfer of substrate to CCT/TriC	27	3.25e-03	9.50e-03	0.3740	0.063600	0.369000	5.67e-01	9.07e-04
Regulation of TP53 Activity through Phosphorylation	91	3.90e-09	6.30e-08	0.3740	0.116000	0.356000	5.55e-02	4.63e-09
Eukaryotic Translation Elongation	90	6.66e-09	1.00e-07	0.3740	0.013900	0.373000	8.20e-01	9.21e-10
Negative regulation of NOTCH4 signaling	53	1.20e-05	7.26e-05	0.3730	0.173000	0.331000	2.96e-02	3.10e-05
Degradation of GLI2 by the proteasome	56	6.41e-06	4.31e-05	0.3730	0.176000	0.329000	2.30e-02	2.06e-05
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.60e-02	5.51e-02	0.3730	0.238000	0.287000	8.92e-02	4.06e-02
Glycosphingolipid metabolism	40	2.56e-04	1.07e-03	0.3720	0.019400	-0.372000	8.32e-01	4.78e-05
APC/C:Cdc20 mediated degradation of Securin	65	1.26e-06	1.03e-05	0.3710	0.090100	0.360000	2.09e-01	5.21e-07
Viral mRNA Translation	86	1.95e-08	2.51e-07	0.3710	0.017600	0.371000	7.79e-01	2.84e-09
Negative epigenetic regulation of rRNA expression	45	7.29e-05	3.53e-04	0.3710	0.194000	0.317000	2.47e-02	2.39e-04
HCMV Early Events	58	5.82e-06	3.98e-05	0.3710	0.057900	0.366000	4.45e-01	1.40e-06
Cell Cycle	603	1.48e-53	1.11e-50	0.3710	0.055200	0.366000	2.11e-02	3.71e-53
Regulation of RUNX3 expression and activity	54	1.11e-05	6.77e-05	0.3700	0.208000	0.307000	8.19e-03	9.80e-05
Acyl chain remodelling of PG	15	4.27e-02	8.38e-02	0.3700	-0.342000	-0.143000	2.20e-02	3.37e-01
Mitotic Prometaphase	177	1.75e-16	8.49e-15	0.3700	0.044200	0.367000	3.11e-01	3.65e-17
Butyrophilin (BTN) family interactions	11	1.12e-01	1.82e-01	0.3690	0.195000	-0.313000	2.62e-01	7.18e-02
mRNA Splicing	182	3.84e-17	1.99e-15	0.3690	0.163000	0.331000	1.53e-04	1.29e-14
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	92	7.35e-09	1.08e-07	0.3690	0.013900	0.368000	8.18e-01	1.02e-09
Formation of the ternary complex, and subsequently, the 43S complex	50	3.70e-05	1.97e-04	0.3680	0.035800	0.366000	6.62e-01	7.42e-06
Synthesis of PIPs at the late endosome membrane	11	1.14e-01	1.84e-01	0.3680	0.193000	-0.313000	2.67e-01	7.24e-02
MAPK targets/ Nuclear events mediated by MAP kinases	31	2.23e-03	6.97e-03	0.3680	0.205000	-0.305000	4.87e-02	3.25e-03
Hh mutants abrogate ligand secretion	56	9.09e-06	5.82e-05	0.3670	0.198000	0.309000	1.05e-02	6.27e-05
PI3K events in ERBB2 signaling	16	3.78e-02	7.54e-02	0.3670	-0.089700	-0.356000	5.35e-01	1.38e-02
DAG and IP3 signaling	39	3.07e-04	1.24e-03	0.3670	-0.243000	-0.275000	8.75e-03	2.98e-03
Translation initiation complex formation	57	1.08e-05	6.62e-05	0.3660	-0.004870	0.366000	9.49e-01	1.73e-06
Nuclear signaling by ERBB4	31	1.67e-03	5.46e-03	0.3660	-0.204000	-0.304000	4.92e-02	3.45e-03
CTNNB1 S33 mutants aren’t phosphorylated	15	5.17e-02	9.88e-02	0.3650	0.355000	-0.088300	1.74e-02	5.54e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	5.17e-02	9.88e-02	0.3650	0.355000	-0.088300	1.74e-02	5.54e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	5.17e-02	9.88e-02	0.3650	0.355000	-0.088300	1.74e-02	5.54e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	5.17e-02	9.88e-02	0.3650	0.355000	-0.088300	1.74e-02	5.54e-01
Signaling by CTNNB1 phospho-site mutants	15	5.17e-02	9.88e-02	0.3650	0.355000	-0.088300	1.74e-02	5.54e-01
Signaling by GSK3beta mutants	15	5.17e-02	9.88e-02	0.3650	0.355000	-0.088300	1.74e-02	5.54e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	9.67e-02	1.63e-01	0.3650	0.176000	-0.319000	2.90e-01	5.54e-02
alpha-linolenic acid (ALA) metabolism	12	9.67e-02	1.63e-01	0.3650	0.176000	-0.319000	2.90e-01	5.54e-02
RNA Polymerase I Transcription Termination	26	5.14e-03	1.39e-02	0.3640	0.151000	0.331000	1.83e-01	3.51e-03
Glycolysis	67	1.75e-06	1.40e-05	0.3640	0.004300	0.363000	9.51e-01	2.68e-07
GLI3 is processed to GLI3R by the proteasome	56	1.21e-05	7.29e-05	0.3630	0.178000	0.316000	2.16e-02	4.21e-05
Mitochondrial tRNA aminoacylation	18	2.79e-02	5.83e-02	0.3630	0.046700	0.360000	7.31e-01	8.23e-03
Peptide chain elongation	86	4.38e-08	5.26e-07	0.3630	0.013400	0.362000	8.31e-01	6.30e-09
MET activates PTK2 signaling	18	2.59e-02	5.48e-02	0.3630	-0.277000	-0.234000	4.18e-02	8.60e-02
Inhibition of DNA recombination at telomere	21	1.41e-02	3.31e-02	0.3620	0.250000	0.263000	4.77e-02	3.71e-02
PERK regulates gene expression	30	2.31e-03	7.19e-03	0.3620	0.225000	0.283000	3.26e-02	7.23e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	5.49e-02	1.03e-01	0.3620	0.348000	-0.101000	1.97e-02	5.00e-01
Xenobiotics	23	9.82e-03	2.42e-02	0.3620	-0.328000	-0.153000	6.50e-03	2.03e-01
Transcription of the HIV genome	64	3.04e-06	2.26e-05	0.3610	0.108000	0.345000	1.35e-01	1.87e-06
WNT ligand biogenesis and trafficking	24	8.22e-03	2.08e-02	0.3610	0.320000	0.166000	6.62e-03	1.59e-01
Translesion synthesis by POLI	17	3.54e-02	7.11e-02	0.3590	0.114000	0.340000	4.14e-01	1.52e-02
Regulation of RUNX2 expression and activity	70	1.06e-06	9.09e-06	0.3580	0.193000	0.301000	5.20e-03	1.36e-05
Response of EIF2AK4 (GCN2) to amino acid deficiency	97	8.65e-09	1.25e-07	0.3570	0.032300	0.356000	5.83e-01	1.45e-09
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.95e-02	4.30e-02	0.3570	-0.103000	0.341000	4.16e-01	6.76e-03
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.95e-02	4.30e-02	0.3570	-0.103000	0.341000	4.16e-01	6.76e-03
Defective CFTR causes cystic fibrosis	58	1.27e-05	7.54e-05	0.3560	0.180000	0.307000	1.80e-02	5.27e-05
Regulation of HSF1-mediated heat shock response	75	5.74e-07	5.29e-06	0.3560	0.082900	0.346000	2.15e-01	2.27e-07
Cell recruitment (pro-inflammatory response)	25	8.13e-03	2.06e-02	0.3550	-0.099700	-0.341000	3.88e-01	3.15e-03
Purinergic signaling in leishmaniasis infection	25	8.13e-03	2.06e-02	0.3550	-0.099700	-0.341000	3.88e-01	3.15e-03
Urea cycle	10	1.43e-01	2.19e-01	0.3550	-0.247000	-0.255000	1.76e-01	1.63e-01
FOXO-mediated transcription of cell death genes	16	5.33e-02	1.02e-01	0.3540	0.311000	-0.170000	3.15e-02	2.39e-01
Activation of SMO	17	4.53e-02	8.84e-02	0.3540	0.215000	-0.281000	1.26e-01	4.48e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	37	8.48e-04	3.00e-03	0.3530	0.140000	0.324000	1.41e-01	6.39e-04
HIV Transcription Elongation	37	8.48e-04	3.00e-03	0.3530	0.140000	0.324000	1.41e-01	6.39e-04
Tat-mediated elongation of the HIV-1 transcript	37	8.48e-04	3.00e-03	0.3530	0.140000	0.324000	1.41e-01	6.39e-04
Translesion synthesis by POLK	17	3.89e-02	7.73e-02	0.3530	0.137000	0.325000	3.28e-01	2.02e-02
InlB-mediated entry of Listeria monocytogenes into host cell	15	6.07e-02	1.12e-01	0.3530	-0.008510	-0.353000	9.55e-01	1.81e-02
Gap junction assembly	16	5.04e-02	9.74e-02	0.3520	0.022400	0.351000	8.77e-01	1.50e-02
Cyclin E associated events during G1/S transition	82	1.78e-07	1.85e-06	0.3520	0.146000	0.320000	2.21e-02	5.40e-07
Hyaluronan metabolism	16	5.58e-02	1.05e-01	0.3520	0.228000	-0.268000	1.14e-01	6.36e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	86	8.75e-08	9.75e-07	0.3510	0.176000	0.304000	4.92e-03	1.11e-06
Ion homeostasis	49	9.49e-05	4.49e-04	0.3510	-0.310000	-0.164000	1.71e-04	4.73e-02
Phase 2 - plateau phase	13	8.46e-02	1.48e-01	0.3510	-0.199000	-0.289000	2.14e-01	7.12e-02
Degradation of AXIN	52	5.35e-05	2.70e-04	0.3510	0.181000	0.300000	2.38e-02	1.80e-04
Selenocysteine synthesis	89	7.86e-08	8.96e-07	0.3510	-0.002510	0.351000	9.67e-01	1.07e-08
Cyclin A:Cdk2-associated events at S phase entry	84	1.38e-07	1.49e-06	0.3510	0.149000	0.317000	1.84e-02	4.94e-07
Ion transport by P-type ATPases	52	5.99e-05	2.96e-04	0.3510	-0.337000	-0.097900	2.69e-05	2.22e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	1.28e-04	5.89e-04	0.3490	0.137000	0.321000	9.99e-02	1.19e-04
Nicotinamide salvaging	14	7.75e-02	1.38e-01	0.3490	0.009460	-0.349000	9.51e-01	2.37e-02
Degradation of GLI1 by the proteasome	56	2.85e-05	1.60e-04	0.3490	0.179000	0.299000	2.04e-02	1.08e-04
Negative regulation of FGFR1 signaling	27	8.56e-03	2.16e-02	0.3480	0.253000	-0.239000	2.27e-02	3.18e-02
Cristae formation	11	1.41e-01	2.18e-01	0.3480	-0.140000	0.319000	4.22e-01	6.70e-02
M Phase	336	4.50e-27	4.84e-25	0.3480	0.056400	0.344000	7.62e-02	3.02e-27
Ribosomal scanning and start codon recognition	57	3.33e-05	1.79e-04	0.3480	-0.007160	0.348000	9.26e-01	5.61e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	112	1.45e-09	2.67e-08	0.3470	0.057600	0.342000	2.93e-01	3.92e-10
Nonsense-Mediated Decay (NMD)	112	1.45e-09	2.67e-08	0.3470	0.057600	0.342000	2.93e-01	3.92e-10
Regulation of expression of SLITs and ROBOs	163	1.28e-13	4.39e-12	0.3470	0.101000	0.332000	2.64e-02	2.73e-13
Interferon alpha/beta signaling	60	2.77e-05	1.56e-04	0.3470	0.186000	-0.293000	1.28e-02	8.89e-05
Regulation of beta-cell development	38	9.23e-04	3.24e-03	0.3460	0.303000	0.166000	1.21e-03	7.63e-02
Passive transport by Aquaporins	10	1.60e-01	2.41e-01	0.3460	-0.150000	-0.312000	4.13e-01	8.80e-02
CaM pathway	33	2.48e-03	7.60e-03	0.3430	-0.245000	-0.240000	1.49e-02	1.68e-02
Calmodulin induced events	33	2.48e-03	7.60e-03	0.3430	-0.245000	-0.240000	1.49e-02	1.68e-02
Signaling by high-kinase activity BRAF mutants	34	2.35e-03	7.29e-03	0.3430	-0.055400	-0.339000	5.76e-01	6.36e-04
Defective Intrinsic Pathway for Apoptosis	25	1.06e-02	2.59e-02	0.3430	0.242000	0.243000	3.63e-02	3.53e-02
Phosphorylation of the APC/C	20	3.16e-02	6.49e-02	0.3430	-0.118000	0.322000	3.63e-01	1.27e-02
Heme degradation	15	7.04e-02	1.27e-01	0.3430	-0.342000	-0.025000	2.19e-02	8.67e-01
Synaptic adhesion-like molecules	21	2.77e-02	5.81e-02	0.3430	-0.264000	0.218000	3.63e-02	8.32e-02
Interleukin-15 signaling	14	9.13e-02	1.56e-01	0.3420	0.195000	-0.282000	2.07e-01	6.80e-02
Formation of the Early Elongation Complex	31	3.95e-03	1.12e-02	0.3410	0.134000	0.314000	1.95e-01	2.50e-03
Formation of the HIV-1 Early Elongation Complex	31	3.95e-03	1.12e-02	0.3410	0.134000	0.314000	1.95e-01	2.50e-03
NIK–>noncanonical NF-kB signaling	56	4.57e-05	2.37e-04	0.3410	0.145000	0.309000	6.04e-02	6.38e-05
Biosynthesis of specialized proresolving mediators (SPMs)	17	4.89e-02	9.50e-02	0.3410	-0.102000	-0.326000	4.67e-01	2.01e-02
Negative regulation of FGFR2 signaling	28	8.84e-03	2.22e-02	0.3410	0.249000	-0.232000	2.24e-02	3.34e-02
Negative regulation of FGFR4 signaling	27	1.05e-02	2.56e-02	0.3410	0.243000	-0.239000	2.90e-02	3.17e-02
Ca-dependent events	35	1.91e-03	6.11e-03	0.3400	-0.246000	-0.236000	1.19e-02	1.59e-02
Activation of the AP-1 family of transcription factors	10	1.83e-01	2.69e-01	0.3400	0.149000	-0.306000	4.16e-01	9.37e-02
Autodegradation of Cdh1 by Cdh1:APC/C	63	1.54e-05	8.89e-05	0.3400	0.098900	0.325000	1.75e-01	8.00e-06
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	1.41e-01	2.18e-01	0.3400	-0.220000	-0.259000	2.07e-01	1.37e-01
Diseases associated with the TLR signaling cascade	31	4.14e-03	1.15e-02	0.3400	-0.153000	-0.303000	1.42e-01	3.47e-03
Diseases of Immune System	31	4.14e-03	1.15e-02	0.3400	-0.153000	-0.303000	1.42e-01	3.47e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	6.25e-03	1.65e-02	0.3390	0.318000	-0.119000	2.60e-03	2.58e-01
APC truncation mutants have impaired AXIN binding	14	9.11e-02	1.56e-01	0.3390	0.335000	-0.053700	3.00e-02	7.28e-01
AXIN missense mutants destabilize the destruction complex	14	9.11e-02	1.56e-01	0.3390	0.335000	-0.053700	3.00e-02	7.28e-01
Signaling by AMER1 mutants	14	9.11e-02	1.56e-01	0.3390	0.335000	-0.053700	3.00e-02	7.28e-01
Signaling by APC mutants	14	9.11e-02	1.56e-01	0.3390	0.335000	-0.053700	3.00e-02	7.28e-01
Signaling by AXIN mutants	14	9.11e-02	1.56e-01	0.3390	0.335000	-0.053700	3.00e-02	7.28e-01
Truncations of AMER1 destabilize the destruction complex	14	9.11e-02	1.56e-01	0.3390	0.335000	-0.053700	3.00e-02	7.28e-01
Vitamin B5 (pantothenate) metabolism	17	5.35e-02	1.02e-01	0.3390	-0.339000	0.006950	1.55e-02	9.60e-01
SUMOylation of DNA damage response and repair proteins	74	2.95e-06	2.22e-05	0.3380	0.026500	0.337000	6.93e-01	5.26e-07
Retinoid metabolism and transport	39	1.04e-03	3.61e-03	0.3380	-0.285000	-0.182000	2.07e-03	4.90e-02
Formation of HIV elongation complex in the absence of HIV Tat	39	1.07e-03	3.70e-03	0.3380	0.147000	0.305000	1.13e-01	9.95e-04
HSF1 activation	26	1.02e-02	2.50e-02	0.3380	0.185000	0.283000	1.02e-01	1.26e-02
SUMOylation of chromatin organization proteins	54	9.76e-05	4.56e-04	0.3380	0.005850	0.338000	9.41e-01	1.76e-05
B-WICH complex positively regulates rRNA expression	29	6.33e-03	1.67e-02	0.3360	0.247000	0.228000	2.11e-02	3.38e-02
Interferon gamma signaling	88	3.30e-07	3.16e-06	0.3360	-0.029900	-0.335000	6.28e-01	5.80e-08
RHO GTPases Activate Formins	112	4.95e-09	7.83e-08	0.3360	0.080000	0.326000	1.44e-01	2.48e-09
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	13	1.14e-01	1.84e-01	0.3360	0.058800	-0.331000	7.14e-01	3.91e-02
Glucagon signaling in metabolic regulation	28	7.86e-03	2.01e-02	0.3350	-0.187000	-0.278000	8.71e-02	1.08e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	27	1.19e-02	2.84e-02	0.3350	0.302000	-0.143000	6.53e-03	1.97e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	1.90e-02	4.20e-02	0.3350	0.175000	0.285000	1.47e-01	1.78e-02
Attenuation phase	23	1.89e-02	4.20e-02	0.3350	0.193000	0.273000	1.08e-01	2.34e-02
DSCAM interactions	11	1.60e-01	2.41e-01	0.3340	-0.332000	0.042400	5.68e-02	8.08e-01
Interleukin-2 family signaling	37	1.75e-03	5.68e-03	0.3340	-0.179000	-0.282000	5.93e-02	3.03e-03
Sensory perception of taste	35	3.19e-03	9.42e-03	0.3330	-0.328000	0.057800	7.95e-04	5.54e-01
Kinesins	41	1.31e-03	4.43e-03	0.3330	-0.145000	0.299000	1.08e-01	9.14e-04
TP53 Regulates Transcription of Death Receptors and Ligands	12	1.42e-01	2.18e-01	0.3330	0.313000	-0.114000	6.08e-02	4.95e-01
Pausing and recovery of Tat-mediated HIV elongation	27	1.02e-02	2.50e-02	0.3320	0.179000	0.280000	1.07e-01	1.19e-02
Tat-mediated HIV elongation arrest and recovery	27	1.02e-02	2.50e-02	0.3320	0.179000	0.280000	1.07e-01	1.19e-02
Eukaryotic Translation Termination	90	3.87e-07	3.66e-06	0.3310	0.008250	0.331000	8.92e-01	5.76e-08
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	29	7.83e-03	2.01e-02	0.3310	0.121000	0.308000	2.58e-01	4.15e-03
Deadenylation-dependent mRNA decay	55	1.01e-04	4.69e-04	0.3300	0.143000	0.298000	6.71e-02	1.32e-04
Nuclear Envelope Breakdown	51	2.46e-04	1.03e-03	0.3300	-0.020900	0.330000	7.97e-01	4.62e-05
Dual Incision in GG-NER	39	1.56e-03	5.15e-03	0.3300	0.086300	0.319000	3.51e-01	5.75e-04
PI-3K cascade:FGFR1	16	7.94e-02	1.41e-01	0.3300	0.266000	-0.194000	6.51e-02	1.79e-01
DNA Damage/Telomere Stress Induced Senescence	28	9.30e-03	2.32e-02	0.3290	0.171000	0.281000	1.17e-01	9.94e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	1.93e-01	2.81e-01	0.3290	-0.067900	-0.322000	7.10e-01	7.79e-02
MET activates RAP1 and RAC1	11	1.68e-01	2.51e-01	0.3290	-0.006770	-0.328000	9.69e-01	5.93e-02
TNFs bind their physiological receptors	26	1.65e-02	3.76e-02	0.3280	-0.147000	0.294000	1.95e-01	9.52e-03
Gene Silencing by RNA	78	3.50e-06	2.55e-05	0.3280	-0.002110	0.328000	9.74e-01	5.40e-07
Smooth Muscle Contraction	36	3.33e-03	9.58e-03	0.3280	0.106000	-0.311000	2.72e-01	1.26e-03
Negative regulation of MAPK pathway	43	1.10e-03	3.76e-03	0.3280	0.311000	-0.104000	4.16e-04	2.36e-01
Collagen degradation	39	2.23e-03	6.97e-03	0.3280	-0.196000	0.263000	3.38e-02	4.52e-03
Gluconeogenesis	30	8.91e-03	2.23e-02	0.3280	-0.147000	0.293000	1.63e-01	5.46e-03
Biosynthesis of DHA-derived SPMs	15	8.82e-02	1.53e-01	0.3280	-0.021800	-0.327000	8.84e-01	2.83e-02
Sialic acid metabolism	31	6.11e-03	1.62e-02	0.3280	-0.125000	-0.303000	2.28e-01	3.52e-03
MicroRNA (miRNA) biogenesis	24	1.91e-02	4.22e-02	0.3280	0.157000	0.288000	1.84e-01	1.47e-02
Negative regulation of FLT3	15	9.43e-02	1.60e-01	0.3270	0.124000	-0.303000	4.05e-01	4.22e-02
G-protein mediated events	51	2.19e-04	9.28e-04	0.3270	-0.217000	-0.245000	7.41e-03	2.45e-03
Gap-filling DNA repair synthesis and ligation in TC-NER	61	4.85e-05	2.48e-04	0.3270	0.104000	0.310000	1.61e-01	2.83e-05
Paracetamol ADME	24	2.03e-02	4.44e-02	0.3260	-0.313000	-0.093500	8.01e-03	4.28e-01
Inactivation, recovery and regulation of the phototransduction cascade	30	9.81e-03	2.42e-02	0.3260	-0.230000	0.231000	2.96e-02	2.86e-02
Activation of the phototransduction cascade	10	2.13e-01	3.04e-01	0.3260	-0.172000	0.276000	3.46e-01	1.30e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	11	1.65e-01	2.47e-01	0.3260	0.258000	0.198000	1.38e-01	2.55e-01
GAB1 signalosome	17	6.42e-02	1.18e-01	0.3250	-0.120000	-0.302000	3.90e-01	3.13e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	28	1.35e-02	3.19e-02	0.3240	0.286000	-0.153000	8.85e-03	1.61e-01
TNFR1-induced proapoptotic signaling	13	1.36e-01	2.11e-01	0.3240	0.165000	-0.279000	3.03e-01	8.14e-02
DARPP-32 events	23	2.87e-02	5.99e-02	0.3230	0.067600	-0.316000	5.75e-01	8.77e-03
Signaling by Hippo	20	4.83e-02	9.40e-02	0.3230	0.200000	-0.253000	1.21e-01	5.03e-02
Interleukin-7 signaling	22	3.59e-02	7.18e-02	0.3220	0.242000	-0.212000	4.90e-02	8.45e-02
Mitochondrial protein import	56	1.42e-04	6.45e-04	0.3220	0.095100	0.308000	2.19e-01	6.70e-05
Molecules associated with elastic fibres	29	1.27e-02	3.01e-02	0.3220	0.218000	-0.237000	4.21e-02	2.74e-02
CS/DS degradation	14	1.21e-01	1.94e-01	0.3220	0.167000	-0.275000	2.80e-01	7.47e-02
Neurotoxicity of clostridium toxins	10	2.22e-01	3.16e-01	0.3210	-0.220000	0.234000	2.27e-01	2.00e-01
Signaling by RAF1 mutants	39	2.15e-03	6.77e-03	0.3210	-0.104000	-0.304000	2.59e-01	1.03e-03
STAT3 nuclear events downstream of ALK signaling	10	2.03e-01	2.93e-01	0.3210	0.207000	0.245000	2.56e-01	1.79e-01
RNA Polymerase II Pre-transcription Events	75	7.42e-06	4.85e-05	0.3210	0.126000	0.295000	5.87e-02	9.95e-06
Sensory perception of sweet, bitter, and umami (glutamate) taste	29	1.23e-02	2.91e-02	0.3210	-0.306000	0.097500	4.37e-03	3.64e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	61	6.32e-05	3.10e-04	0.3210	0.189000	0.259000	1.05e-02	4.70e-04
Asymmetric localization of PCP proteins	61	6.45e-05	3.15e-04	0.3210	0.179000	0.266000	1.55e-02	3.28e-04
Caspase-mediated cleavage of cytoskeletal proteins	12	1.62e-01	2.43e-01	0.3210	0.090500	-0.308000	5.87e-01	6.51e-02
Listeria monocytogenes entry into host cells	20	4.97e-02	9.63e-02	0.3190	0.097600	-0.304000	4.50e-01	1.87e-02
Caspase activation via extrinsic apoptotic signalling pathway	25	2.42e-02	5.15e-02	0.3190	0.136000	-0.288000	2.38e-01	1.26e-02
PI-3K cascade:FGFR2	17	8.06e-02	1.42e-01	0.3190	0.259000	-0.186000	6.46e-02	1.84e-01
VxPx cargo-targeting to cilium	20	4.50e-02	8.81e-02	0.3190	-0.301000	-0.104000	1.97e-02	4.21e-01
Integrin signaling	27	1.61e-02	3.70e-02	0.3180	-0.030500	-0.317000	7.84e-01	4.36e-03
Prolonged ERK activation events	14	1.26e-01	2.01e-01	0.3180	0.188000	-0.257000	2.24e-01	9.56e-02
Collagen biosynthesis and modifying enzymes	63	9.54e-05	4.50e-04	0.3180	-0.254000	0.191000	4.92e-04	8.62e-03
APC-Cdc20 mediated degradation of Nek2A	26	2.06e-02	4.50e-02	0.3170	-0.055700	0.312000	6.23e-01	5.85e-03
Cross-presentation of soluble exogenous antigens (endosomes)	47	7.80e-04	2.81e-03	0.3160	0.086200	0.304000	3.07e-01	3.06e-04
HIV elongation arrest and recovery	29	1.14e-02	2.73e-02	0.3160	0.186000	0.256000	8.35e-02	1.70e-02
Pausing and recovery of HIV elongation	29	1.14e-02	2.73e-02	0.3160	0.186000	0.256000	8.35e-02	1.70e-02
Mitotic G2-G2/M phases	178	2.44e-12	6.79e-11	0.3160	0.065100	0.309000	1.35e-01	1.16e-12
PI-3K cascade:FGFR4	16	9.85e-02	1.65e-01	0.3150	0.249000	-0.194000	8.52e-02	1.79e-01
Assembly of collagen fibrils and other multimeric structures	56	3.09e-04	1.25e-03	0.3150	-0.234000	0.211000	2.44e-03	6.30e-03
Cellular hexose transport	18	7.19e-02	1.30e-01	0.3140	-0.310000	0.044900	2.26e-02	7.41e-01
RHO GTPases activate CIT	19	6.56e-02	1.20e-01	0.3140	0.263000	-0.171000	4.72e-02	1.98e-01
Cytosolic sulfonation of small molecules	19	6.14e-02	1.13e-01	0.3130	0.007270	-0.313000	9.56e-01	1.82e-02
Signaling by FGFR4	37	5.22e-03	1.41e-02	0.3120	0.279000	-0.139000	3.30e-03	1.45e-01
Phospholipase C-mediated cascade: FGFR1	11	2.09e-01	3.00e-01	0.3120	0.283000	-0.130000	1.04e-01	4.54e-01
G2/M Transition	176	6.73e-12	1.81e-10	0.3110	0.069100	0.304000	1.14e-01	3.76e-12
DAP12 interactions	39	2.97e-03	8.84e-03	0.3110	-0.196000	-0.241000	3.39e-02	9.17e-03
Glucose metabolism	85	5.25e-06	3.64e-05	0.3110	-0.052100	0.307000	4.07e-01	1.04e-06
Telomere Extension By Telomerase	23	3.35e-02	6.83e-02	0.3100	0.142000	0.275000	2.37e-01	2.23e-02
Signaling by FGFR2 IIIa TM	19	5.96e-02	1.11e-01	0.3100	0.217000	0.221000	1.02e-01	9.47e-02
Cleavage of the damaged pyrimidine	16	9.35e-02	1.59e-01	0.3100	0.191000	0.244000	1.87e-01	9.10e-02
Depyrimidination	16	9.35e-02	1.59e-01	0.3100	0.191000	0.244000	1.87e-01	9.10e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	9.35e-02	1.59e-01	0.3100	0.191000	0.244000	1.87e-01	9.10e-02
Mitochondrial iron-sulfur cluster biogenesis	12	1.73e-01	2.56e-01	0.3090	0.296000	0.091000	7.61e-02	5.85e-01
TP53 Regulates Transcription of DNA Repair Genes	56	2.80e-04	1.16e-03	0.3090	0.116000	0.286000	1.33e-01	2.09e-04
Ras activation upon Ca2+ influx through NMDA receptor	20	6.20e-02	1.14e-01	0.3090	-0.248000	0.184000	5.50e-02	1.53e-01
G beta:gamma signalling through PI3Kgamma	20	5.39e-02	1.02e-01	0.3090	-0.115000	-0.287000	3.72e-01	2.65e-02
Tandem pore domain potassium channels	11	2.09e-01	3.00e-01	0.3080	-0.021800	0.308000	9.00e-01	7.73e-02
Dectin-1 mediated noncanonical NF-kB signaling	59	1.95e-04	8.42e-04	0.3080	0.128000	0.280000	8.91e-02	2.03e-04
The canonical retinoid cycle in rods (twilight vision)	21	5.47e-02	1.03e-01	0.3070	-0.281000	0.124000	2.59e-02	3.24e-01
RNA polymerase II transcribes snRNA genes	69	4.55e-05	2.37e-04	0.3070	0.162000	0.261000	1.97e-02	1.82e-04
RNA Polymerase III Chain Elongation	18	7.42e-02	1.33e-01	0.3060	0.173000	0.252000	2.03e-01	6.38e-02
Downregulation of ERBB2 signaling	28	1.89e-02	4.20e-02	0.3060	-0.066400	-0.298000	5.43e-01	6.31e-03
Nuclear events mediated by NFE2L2	78	1.56e-05	8.98e-05	0.3050	0.105000	0.286000	1.08e-01	1.23e-05
O-linked glycosylation	101	6.78e-07	6.14e-06	0.3050	-0.297000	-0.069100	2.54e-07	2.31e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	5.95e-02	1.10e-01	0.3040	0.290000	0.090300	2.45e-02	4.84e-01
Collagen formation	86	1.00e-05	6.27e-05	0.3040	-0.236000	0.192000	1.59e-04	2.13e-03
Early Phase of HIV Life Cycle	14	1.43e-01	2.19e-01	0.3040	0.016500	0.303000	9.15e-01	4.94e-02
Binding and Uptake of Ligands by Scavenger Receptors	40	3.45e-03	9.90e-03	0.3030	-0.249000	-0.173000	6.44e-03	5.80e-02
DNA Repair	272	4.91e-17	2.46e-15	0.3030	0.082300	0.292000	1.97e-02	1.33e-16
Regulated proteolysis of p75NTR	11	2.30e-01	3.25e-01	0.3010	0.101000	-0.284000	5.61e-01	1.03e-01
Neurexins and neuroligins	56	6.03e-04	2.25e-03	0.3010	-0.269000	0.135000	4.98e-04	8.05e-02
Other interleukin signaling	24	3.93e-02	7.79e-02	0.3010	0.028700	-0.299000	8.08e-01	1.11e-02
Sensory Perception	257	1.56e-15	6.91e-14	0.3000	-0.299000	0.032000	1.83e-16	3.78e-01
Adenylate cyclase inhibitory pathway	13	1.64e-01	2.45e-01	0.3000	-0.190000	-0.233000	2.36e-01	1.46e-01
Host Interactions of HIV factors	123	5.78e-08	6.85e-07	0.3000	0.053000	0.295000	3.10e-01	1.60e-08
MET promotes cell motility	29	1.80e-02	4.05e-02	0.3000	-0.186000	-0.235000	8.37e-02	2.83e-02
EGFR downregulation	31	1.64e-02	3.75e-02	0.3000	0.074700	-0.290000	4.72e-01	5.17e-03
The phototransduction cascade	31	1.78e-02	4.01e-02	0.2990	-0.208000	0.214000	4.47e-02	3.89e-02
RIP-mediated NFkB activation via ZBP1	17	1.08e-01	1.78e-01	0.2990	0.106000	-0.279000	4.49e-01	4.63e-02
ATF4 activates genes in response to endoplasmic reticulum stress	25	3.22e-02	6.59e-02	0.2980	0.230000	0.190000	4.66e-02	1.00e-01
Phospholipase C-mediated cascade; FGFR2	12	2.09e-01	3.00e-01	0.2980	0.271000	-0.124000	1.04e-01	4.57e-01
GRB2 events in ERBB2 signaling	16	1.15e-01	1.85e-01	0.2980	-0.278000	-0.105000	5.40e-02	4.66e-01
NCAM signaling for neurite out-growth	55	6.86e-04	2.51e-03	0.2980	-0.298000	0.001210	1.36e-04	9.88e-01
Growth hormone receptor signaling	23	4.58e-02	8.91e-02	0.2970	-0.066000	-0.290000	5.84e-01	1.62e-02
Apoptotic factor-mediated response	18	8.90e-02	1.54e-01	0.2970	0.286000	0.079100	3.55e-02	5.61e-01
Selenoamino acid metabolism	105	1.03e-06	8.91e-06	0.2970	0.001270	0.297000	9.82e-01	1.53e-07
Insulin receptor recycling	24	4.27e-02	8.38e-02	0.2950	-0.025600	-0.294000	8.28e-01	1.26e-02
MAP2K and MAPK activation	38	6.68e-03	1.75e-02	0.2950	-0.051600	-0.291000	5.82e-01	1.94e-03
Interleukin-10 signaling	44	2.83e-03	8.48e-03	0.2950	-0.137000	-0.261000	1.17e-01	2.72e-03
Eicosanoids	11	2.36e-01	3.31e-01	0.2940	-0.290000	-0.050800	9.61e-02	7.71e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	2.42e-01	3.37e-01	0.2940	-0.031000	0.292000	8.59e-01	9.31e-02
Membrane binding and targetting of GAG proteins	14	1.72e-01	2.55e-01	0.2940	0.153000	-0.251000	3.23e-01	1.04e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.72e-01	2.55e-01	0.2940	0.153000	-0.251000	3.23e-01	1.04e-01
Degradation of beta-catenin by the destruction complex	81	2.19e-05	1.25e-04	0.2930	0.222000	0.192000	5.68e-04	2.80e-03
Aquaporin-mediated transport	42	4.10e-03	1.15e-02	0.2930	-0.089500	-0.279000	3.16e-01	1.76e-03
Vasopressin regulates renal water homeostasis via Aquaporins	36	9.47e-03	2.36e-02	0.2930	-0.031000	-0.291000	7.48e-01	2.49e-03
Hedgehog ligand biogenesis	62	2.92e-04	1.19e-03	0.2920	0.142000	0.256000	5.32e-02	5.00e-04
Formation of RNA Pol II elongation complex	52	1.08e-03	3.71e-03	0.2920	0.154000	0.248000	5.45e-02	1.95e-03
RNA Polymerase II Transcription Elongation	52	1.08e-03	3.71e-03	0.2920	0.154000	0.248000	5.45e-02	1.95e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	5.73e-05	2.84e-04	0.2920	0.106000	0.272000	1.11e-01	4.65e-05
Cellular response to hypoxia	69	1.15e-04	5.33e-04	0.2920	0.215000	0.198000	2.00e-03	4.56e-03
Base-Excision Repair, AP Site Formation	18	9.34e-02	1.59e-01	0.2920	0.191000	0.221000	1.60e-01	1.05e-01
Dual incision in TC-NER	62	3.30e-04	1.32e-03	0.2910	0.091200	0.277000	2.14e-01	1.65e-04
Nonhomologous End-Joining (NHEJ)	32	1.75e-02	3.94e-02	0.2910	-0.027400	0.290000	7.89e-01	4.52e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF	43	4.04e-03	1.13e-02	0.2910	-0.039500	-0.289000	6.55e-01	1.06e-03
Signaling by RAS mutants	43	4.04e-03	1.13e-02	0.2910	-0.039500	-0.289000	6.55e-01	1.06e-03
Signaling by moderate kinase activity BRAF mutants	43	4.04e-03	1.13e-02	0.2910	-0.039500	-0.289000	6.55e-01	1.06e-03
Signaling downstream of RAS mutants	43	4.04e-03	1.13e-02	0.2910	-0.039500	-0.289000	6.55e-01	1.06e-03
Regulation of RAS by GAPs	65	2.22e-04	9.35e-04	0.2910	0.128000	0.261000	7.34e-02	2.78e-04
Killing mechanisms	10	2.85e-01	3.79e-01	0.2900	-0.288000	0.036800	1.15e-01	8.40e-01
WNT5:FZD7-mediated leishmania damping	10	2.85e-01	3.79e-01	0.2900	-0.288000	0.036800	1.15e-01	8.40e-01
Cellular response to heat stress	93	6.69e-06	4.45e-05	0.2900	0.091000	0.276000	1.30e-01	4.38e-06
Semaphorin interactions	64	3.57e-04	1.41e-03	0.2900	0.054100	-0.284000	4.54e-01	8.35e-05
Voltage gated Potassium channels	43	5.18e-03	1.40e-02	0.2890	-0.134000	0.257000	1.29e-01	3.59e-03
Signaling by BRAF and RAF1 fusions	61	4.50e-04	1.74e-03	0.2890	-0.046000	-0.286000	5.34e-01	1.15e-04
Incretin synthesis, secretion, and inactivation	18	1.03e-01	1.72e-01	0.2880	0.280000	0.068500	3.97e-02	6.15e-01
Phospholipase C-mediated cascade; FGFR4	11	2.63e-01	3.58e-01	0.2880	0.257000	-0.130000	1.40e-01	4.54e-01
Late Phase of HIV Life Cycle	128	1.03e-07	1.14e-06	0.2880	0.076400	0.278000	1.36e-01	5.80e-08
Activation of NF-kappaB in B cells	64	3.03e-04	1.24e-03	0.2880	0.104000	0.269000	1.51e-01	2.03e-04
HIV Life Cycle	141	2.14e-08	2.73e-07	0.2880	0.072300	0.279000	1.39e-01	1.15e-08
Regulation of TNFR1 signaling	33	1.87e-02	4.18e-02	0.2880	0.156000	-0.241000	1.20e-01	1.64e-02
Cleavage of the damaged purine	11	2.48e-01	3.43e-01	0.2860	0.199000	0.206000	2.53e-01	2.37e-01
Depurination	11	2.48e-01	3.43e-01	0.2860	0.199000	0.206000	2.53e-01	2.37e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	2.48e-01	3.43e-01	0.2860	0.199000	0.206000	2.53e-01	2.37e-01
Platelet calcium homeostasis	27	3.32e-02	6.77e-02	0.2860	-0.160000	-0.237000	1.49e-01	3.31e-02
Signaling by ALK fusions and activated point mutants	53	1.80e-03	5.77e-03	0.2860	0.257000	-0.125000	1.22e-03	1.16e-01
Signaling by ALK in cancer	53	1.80e-03	5.77e-03	0.2860	0.257000	-0.125000	1.22e-03	1.16e-01
Nuclear events stimulated by ALK signaling in cancer	19	1.05e-01	1.75e-01	0.2850	0.162000	-0.234000	2.20e-01	7.70e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	1.72e-01	2.55e-01	0.2850	0.221000	0.181000	1.53e-01	2.41e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	1.72e-01	2.55e-01	0.2850	0.221000	0.181000	1.53e-01	2.41e-01
FGFR2 mutant receptor activation	27	3.45e-02	6.97e-02	0.2850	0.244000	0.147000	2.83e-02	1.87e-01
Plasma lipoprotein clearance	36	1.44e-02	3.36e-02	0.2850	0.192000	-0.210000	4.65e-02	2.90e-02
Metabolism of fat-soluble vitamins	43	4.63e-03	1.27e-02	0.2850	-0.209000	-0.193000	1.75e-02	2.87e-02
Triglyceride biosynthesis	10	2.90e-01	3.84e-01	0.2840	-0.101000	-0.266000	5.82e-01	1.45e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	2.21e-04	9.32e-04	0.2840	0.132000	0.252000	5.97e-02	3.34e-04
Downregulation of ERBB2:ERBB3 signaling	13	2.10e-01	3.01e-01	0.2840	0.049100	-0.280000	7.59e-01	8.06e-02
Regulation of TP53 Activity	158	3.72e-09	6.14e-08	0.2840	0.122000	0.257000	8.26e-03	2.70e-08
G-protein beta:gamma signalling	27	3.57e-02	7.16e-02	0.2840	-0.123000	-0.256000	2.69e-01	2.16e-02
Apoptotic cleavage of cell adhesion proteins	11	2.56e-01	3.51e-01	0.2830	0.182000	0.218000	2.97e-01	2.12e-01
Nucleotide-like (purinergic) receptors	13	2.00e-01	2.89e-01	0.2830	-0.209000	-0.191000	1.91e-01	2.34e-01
Reproduction	73	1.57e-04	7.04e-04	0.2830	0.010700	0.283000	8.74e-01	2.97e-05
UCH proteinases	81	4.65e-05	2.40e-04	0.2830	0.180000	0.218000	5.11e-03	6.89e-04
Visual phototransduction	88	2.89e-05	1.62e-04	0.2820	-0.282000	0.016600	4.88e-06	7.88e-01
MECP2 regulates neuronal receptors and channels	17	1.27e-01	2.01e-01	0.2820	0.261000	0.106000	6.26e-02	4.49e-01
SUMOylation of immune response proteins	11	2.70e-01	3.66e-01	0.2810	0.280000	0.017800	1.07e-01	9.19e-01
RHO GTPases activate PAKs	21	8.76e-02	1.52e-01	0.2810	0.100000	-0.262000	4.26e-01	3.74e-02
Signaling by FGFR2 in disease	37	1.16e-02	2.78e-02	0.2800	0.247000	0.131000	9.22e-03	1.68e-01
Recycling of bile acids and salts	18	1.21e-01	1.94e-01	0.2800	-0.280000	0.005730	3.98e-02	9.66e-01
Complex I biogenesis	51	2.11e-03	6.67e-03	0.2800	0.199000	0.197000	1.42e-02	1.49e-02
Telomere C-strand synthesis initiation	12	2.38e-01	3.32e-01	0.2800	0.101000	0.261000	5.43e-01	1.18e-01
The NLRP3 inflammasome	16	1.59e-01	2.39e-01	0.2790	0.078000	-0.268000	5.89e-01	6.34e-02
Late endosomal microautophagy	32	2.57e-02	5.45e-02	0.2790	0.088500	-0.265000	3.86e-01	9.62e-03
Plasma lipoprotein assembly	15	1.66e-01	2.48e-01	0.2780	-0.172000	-0.219000	2.49e-01	1.42e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	7.21e-02	1.30e-01	0.2780	0.219000	0.172000	7.57e-02	1.63e-01
Neurodegenerative Diseases	22	7.21e-02	1.30e-01	0.2780	0.219000	0.172000	7.57e-02	1.63e-01
Signaling by FGFR1	44	7.12e-03	1.86e-02	0.2780	0.221000	-0.169000	1.12e-02	5.31e-02
MASTL Facilitates Mitotic Progression	10	3.04e-01	3.99e-01	0.2770	0.206000	0.186000	2.59e-01	3.10e-01
Interleukin-17 signaling	67	5.17e-04	1.95e-03	0.2770	0.086200	-0.264000	2.23e-01	1.92e-04
Caspase activation via Death Receptors in the presence of ligand	15	1.86e-01	2.72e-01	0.2770	0.152000	-0.232000	3.07e-01	1.21e-01
Lysosome Vesicle Biogenesis	33	2.36e-02	5.04e-02	0.2770	0.064900	-0.269000	5.19e-01	7.39e-03
Long-term potentiation	23	7.32e-02	1.31e-01	0.2770	-0.271000	0.057900	2.45e-02	6.31e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	20	9.42e-02	1.60e-01	0.2770	-0.231000	-0.152000	7.36e-02	2.38e-01
Meiotic synapsis	31	2.73e-02	5.74e-02	0.2760	0.081000	0.264000	4.35e-01	1.10e-02
Metabolism of amine-derived hormones	12	2.57e-01	3.53e-01	0.2760	-0.273000	0.033600	1.01e-01	8.40e-01
Signaling by FGFR2	67	4.45e-04	1.73e-03	0.2750	0.266000	0.071300	1.67e-04	3.13e-01
Frs2-mediated activation	12	2.66e-01	3.61e-01	0.2750	0.178000	-0.211000	2.87e-01	2.07e-01
Thrombin signalling through proteinase activated receptors (PARs)	27	5.05e-02	9.74e-02	0.2750	0.148000	-0.232000	1.83e-01	3.67e-02
Reduction of cytosolic Ca++ levels	12	2.56e-01	3.52e-01	0.2750	-0.275000	0.002430	9.89e-02	9.88e-01
FGFR1 ligand binding and activation	10	3.32e-01	4.28e-01	0.2750	0.230000	-0.151000	2.08e-01	4.09e-01
MAPK6/MAPK4 signaling	85	5.31e-05	2.69e-04	0.2750	0.149000	0.231000	1.80e-02	2.33e-04
Nef mediated downregulation of MHC class I complex cell surface expression	10	3.33e-01	4.29e-01	0.2740	0.137000	-0.238000	4.53e-01	1.93e-01
RUNX3 regulates NOTCH signaling	14	2.16e-01	3.08e-01	0.2730	0.257000	-0.092000	9.61e-02	5.51e-01
RHOBTB2 GTPase cycle	23	7.38e-02	1.32e-01	0.2730	0.071400	0.263000	5.53e-01	2.88e-02
Intraflagellar transport	35	1.98e-02	4.35e-02	0.2730	-0.018700	-0.272000	8.48e-01	5.33e-03
Ion channel transport	169	5.40e-09	8.29e-08	0.2720	-0.251000	-0.106000	1.90e-08	1.77e-02
Aspartate and asparagine metabolism	12	2.71e-01	3.67e-01	0.2720	-0.080600	0.259000	6.29e-01	1.20e-01
Synthesis of IP3 and IP4 in the cytosol	26	5.38e-02	1.02e-01	0.2720	-0.081700	-0.259000	4.71e-01	2.23e-02
HDACs deacetylate histones	31	2.99e-02	6.20e-02	0.2710	0.178000	0.204000	8.62e-02	4.92e-02
SUMOylation of intracellular receptors	30	3.51e-02	7.09e-02	0.2710	-0.081100	-0.258000	4.42e-01	1.44e-02
LDL clearance	19	1.32e-01	2.08e-01	0.2700	0.170000	-0.211000	2.01e-01	1.12e-01
Protein-protein interactions at synapses	87	9.62e-05	4.52e-04	0.2700	-0.241000	0.122000	1.03e-04	4.94e-02
Mitotic Prophase	80	1.45e-04	6.56e-04	0.2700	0.081900	0.257000	2.06e-01	7.18e-05
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	13	2.48e-01	3.43e-01	0.2690	-0.263000	0.054100	1.00e-01	7.36e-01
Constitutive Signaling by Aberrant PI3K in Cancer	72	3.67e-04	1.45e-03	0.2690	-0.080600	-0.256000	2.38e-01	1.69e-04
APC/C:Cdc20 mediated degradation of Cyclin B	24	7.59e-02	1.35e-01	0.2690	-0.029000	0.267000	8.06e-01	2.36e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.56e-01	2.36e-01	0.2680	0.066300	0.260000	6.36e-01	6.36e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.56e-01	2.36e-01	0.2680	0.066300	0.260000	6.36e-01	6.36e-02
Defective B4GALT7 causes EDS, progeroid type	20	1.11e-01	1.82e-01	0.2680	-0.252000	-0.090900	5.08e-02	4.82e-01
Drug ADME	82	1.69e-04	7.42e-04	0.2680	-0.261000	0.062400	4.51e-05	3.29e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.12e-01	3.04e-01	0.2680	0.161000	0.214000	2.98e-01	1.65e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	36	1.96e-02	4.30e-02	0.2680	-0.079900	-0.256000	4.07e-01	7.97e-03
Inflammasomes	21	1.02e-01	1.71e-01	0.2680	-0.053100	-0.262000	6.74e-01	3.75e-02
Signaling by ALK	27	5.11e-02	9.84e-02	0.2670	0.167000	0.208000	1.33e-01	6.09e-02
Interleukin receptor SHC signaling	23	8.04e-02	1.42e-01	0.2660	-0.183000	-0.193000	1.28e-01	1.09e-01
Regulation of BACH1 activity	11	3.17e-01	4.12e-01	0.2660	0.251000	-0.089100	1.50e-01	6.09e-01
Intrinsic Pathway of Fibrin Clot Formation	20	1.18e-01	1.91e-01	0.2650	-0.260000	-0.051700	4.41e-02	6.89e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	23	8.37e-02	1.47e-01	0.2650	-0.226000	-0.138000	6.08e-02	2.52e-01
VEGFR2 mediated cell proliferation	19	1.33e-01	2.09e-01	0.2650	-0.047400	-0.260000	7.20e-01	4.96e-02
Oncogene Induced Senescence	33	3.11e-02	6.40e-02	0.2630	0.258000	0.054100	1.04e-02	5.91e-01
HIV Infection	219	1.10e-10	2.52e-09	0.2630	0.081000	0.251000	3.91e-02	1.73e-10
Response of EIF2AK1 (HRI) to heme deficiency	15	2.08e-01	2.99e-01	0.2630	0.027300	0.262000	8.55e-01	7.91e-02
Activated point mutants of FGFR2	11	3.29e-01	4.25e-01	0.2630	0.222000	-0.142000	2.03e-01	4.14e-01
Global Genome Nucleotide Excision Repair (GG-NER)	82	1.65e-04	7.26e-04	0.2630	0.137000	0.225000	3.21e-02	4.38e-04
Protein methylation	14	2.30e-01	3.25e-01	0.2630	0.048300	0.258000	7.54e-01	9.41e-02
Formation of the beta-catenin:TCF transactivating complex	32	3.43e-02	6.96e-02	0.2620	0.242000	0.101000	1.78e-02	3.23e-01
Fertilization	19	1.45e-01	2.21e-01	0.2620	-0.255000	0.062600	5.47e-02	6.36e-01
Platelet degranulation	121	4.59e-06	3.24e-05	0.2620	0.033600	-0.260000	5.24e-01	8.06e-07
Respiratory electron transport	93	5.52e-05	2.77e-04	0.2620	0.165000	0.203000	6.01e-03	7.04e-04
Stimuli-sensing channels	96	4.67e-05	2.41e-04	0.2620	-0.252000	-0.070900	2.01e-05	2.30e-01
Elastic fibre formation	40	1.87e-02	4.19e-02	0.2620	0.201000	-0.167000	2.79e-02	6.70e-02
RNA Polymerase III Transcription Termination	23	9.18e-02	1.56e-01	0.2610	0.246000	0.085300	4.08e-02	4.79e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	2.76e-01	3.71e-01	0.2600	0.131000	-0.225000	4.13e-01	1.60e-01
RAC1 GTPase cycle	177	1.19e-08	1.67e-07	0.2600	-0.111000	-0.235000	1.08e-02	6.83e-08
Nucleotide Excision Repair	107	1.53e-05	8.87e-05	0.2600	0.125000	0.228000	2.52e-02	4.63e-05
RIPK1-mediated regulated necrosis	29	5.75e-02	1.07e-01	0.2600	0.148000	-0.214000	1.68e-01	4.63e-02
Regulation of necroptotic cell death	29	5.75e-02	1.07e-01	0.2600	0.148000	-0.214000	1.68e-01	4.63e-02
Inactivation of CSF3 (G-CSF) signaling	23	1.03e-01	1.72e-01	0.2600	0.118000	-0.231000	3.26e-01	5.48e-02
Downstream signaling of activated FGFR2	24	8.95e-02	1.55e-01	0.2600	0.258000	-0.029200	2.86e-02	8.04e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	20	1.31e-01	2.07e-01	0.2600	0.260000	0.010200	4.45e-02	9.37e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	5.67e-02	1.06e-01	0.2590	0.074600	0.248000	4.95e-01	2.29e-02
Assembly of active LPL and LIPC lipase complexes	16	1.99e-01	2.89e-01	0.2590	-0.259000	-0.009840	7.31e-02	9.46e-01
Signaling by ROBO receptors	205	1.04e-09	1.96e-08	0.2580	0.091000	0.242000	2.49e-02	2.58e-09
Signaling by cytosolic FGFR1 fusion mutants	17	1.84e-01	2.70e-01	0.2580	0.018900	-0.257000	8.93e-01	6.62e-02
SHC1 events in ERBB2 signaling	22	1.06e-01	1.75e-01	0.2580	-0.136000	-0.219000	2.70e-01	7.56e-02
Response to elevated platelet cytosolic Ca2+	126	4.33e-06	3.10e-05	0.2570	0.022000	-0.256000	6.70e-01	6.97e-07
Post-chaperonin tubulin folding pathway	20	1.43e-01	2.20e-01	0.2570	-0.091200	0.240000	4.80e-01	6.28e-02
NF-kB is activated and signals survival	13	2.82e-01	3.76e-01	0.2570	0.247000	-0.071900	1.23e-01	6.54e-01
TNFR1-induced NFkappaB signaling pathway	25	8.67e-02	1.51e-01	0.2570	0.048700	-0.252000	6.73e-01	2.91e-02
Regulation of IFNA/IFNB signaling	14	2.61e-01	3.57e-01	0.2570	0.178000	-0.185000	2.50e-01	2.30e-01
Defective B3GAT3 causes JDSSDHD	20	1.34e-01	2.10e-01	0.2570	-0.246000	-0.073100	5.69e-02	5.72e-01
DNA Damage Bypass	47	8.66e-03	2.18e-02	0.2560	0.129000	0.221000	1.25e-01	8.67e-03
COPI-dependent Golgi-to-ER retrograde traffic	80	3.76e-04	1.48e-03	0.2560	0.014900	0.256000	8.18e-01	7.63e-05
Oncogenic MAPK signaling	78	4.97e-04	1.89e-03	0.2560	0.029900	-0.255000	6.49e-01	1.02e-04
Synthesis of glycosylphosphatidylinositol (GPI)	17	1.92e-01	2.80e-01	0.2560	0.249000	-0.059400	7.54e-02	6.72e-01
Sphingolipid metabolism	79	4.57e-04	1.76e-03	0.2560	0.021000	-0.255000	7.47e-01	8.98e-05
Prostacyclin signalling through prostacyclin receptor	14	2.63e-01	3.58e-01	0.2560	0.222000	-0.126000	1.50e-01	4.15e-01
CASP8 activity is inhibited	11	3.51e-01	4.46e-01	0.2550	0.210000	-0.145000	2.27e-01	4.05e-01
Dimerization of procaspase-8	11	3.51e-01	4.46e-01	0.2550	0.210000	-0.145000	2.27e-01	4.05e-01
Regulation by c-FLIP	11	3.51e-01	4.46e-01	0.2550	0.210000	-0.145000	2.27e-01	4.05e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	99	6.02e-05	2.96e-04	0.2550	-0.037700	-0.253000	5.17e-01	1.43e-05
TNFR2 non-canonical NF-kB pathway	95	9.03e-05	4.28e-04	0.2550	0.034400	0.253000	5.63e-01	2.07e-05
Class I peroxisomal membrane protein import	20	1.46e-01	2.22e-01	0.2550	0.052300	-0.250000	6.85e-01	5.33e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	6.89e-02	1.25e-01	0.2550	0.084900	0.240000	4.45e-01	3.08e-02
RHOU GTPase cycle	40	2.20e-02	4.78e-02	0.2550	0.074500	-0.243000	4.15e-01	7.73e-03
TCF dependent signaling in response to WNT	168	6.30e-08	7.34e-07	0.2550	0.226000	0.116000	4.22e-07	9.44e-03
Formation of TC-NER Pre-Incision Complex	50	7.37e-03	1.90e-02	0.2540	0.078400	0.241000	3.38e-01	3.14e-03
AURKA Activation by TPX2	69	1.26e-03	4.30e-03	0.2540	0.018600	0.253000	7.90e-01	2.79e-04
Diseases associated with O-glycosylation of proteins	64	1.95e-03	6.24e-03	0.2530	-0.246000	-0.061900	6.76e-04	3.92e-01
Non-integrin membrane-ECM interactions	42	1.58e-02	3.64e-02	0.2530	-0.200000	-0.155000	2.47e-02	8.31e-02
Downstream signaling of activated FGFR4	23	1.13e-01	1.83e-01	0.2530	0.251000	-0.028100	3.73e-02	8.16e-01
LGI-ADAM interactions	13	2.88e-01	3.82e-01	0.2520	0.020200	0.251000	9.00e-01	1.17e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	3.60e-01	4.54e-01	0.2520	0.115000	-0.224000	5.08e-01	1.98e-01
Regulation of PTEN stability and activity	66	1.64e-03	5.38e-03	0.2520	0.118000	0.223000	9.84e-02	1.78e-03
Acetylcholine regulates insulin secretion	10	3.76e-01	4.71e-01	0.2520	-0.195000	-0.158000	2.84e-01	3.86e-01
Blood group systems biosynthesis	18	1.79e-01	2.64e-01	0.2520	-0.250000	-0.029800	6.66e-02	8.27e-01
FGFR4 ligand binding and activation	10	3.98e-01	4.92e-01	0.2520	0.201000	-0.151000	2.70e-01	4.09e-01
Cytochrome c-mediated apoptotic response	13	2.94e-01	3.87e-01	0.2510	0.250000	-0.025100	1.19e-01	8.75e-01
Signaling by FGFR4 in disease	11	3.55e-01	4.51e-01	0.2510	0.251000	-0.007280	1.50e-01	9.67e-01
Synthesis of PIPs at the early endosome membrane	16	2.23e-01	3.16e-01	0.2510	0.016700	-0.250000	9.08e-01	8.33e-02
Synthesis of bile acids and bile salts	33	4.09e-02	8.09e-02	0.2500	-0.179000	-0.175000	7.49e-02	8.19e-02
Regulation of IFNG signaling	14	2.69e-01	3.64e-01	0.2500	-0.014600	-0.249000	9.24e-01	1.06e-01
Diseases of carbohydrate metabolism	31	5.41e-02	1.02e-01	0.2500	-0.029800	-0.248000	7.74e-01	1.69e-02
Assembly and cell surface presentation of NMDA receptors	25	1.04e-01	1.73e-01	0.2490	-0.209000	0.136000	7.03e-02	2.40e-01
PIWI-interacting RNA (piRNA) biogenesis	29	6.99e-02	1.27e-01	0.2490	-0.060100	0.242000	5.76e-01	2.42e-02
TBC/RABGAPs	43	1.91e-02	4.23e-02	0.2490	0.036800	-0.246000	6.76e-01	5.22e-03
SHC1 events in ERBB4 signaling	14	2.68e-01	3.64e-01	0.2490	-0.244000	-0.046800	1.13e-01	7.62e-01
Metabolism of nucleotides	92	2.29e-04	9.59e-04	0.2490	-0.060600	0.241000	3.15e-01	6.39e-05
Downstream signaling of activated FGFR1	26	9.11e-02	1.56e-01	0.2490	0.247000	-0.027900	2.92e-02	8.06e-01
KEAP1-NFE2L2 pathway	99	8.66e-05	4.14e-04	0.2490	0.109000	0.223000	6.07e-02	1.24e-04
Platelet activation, signaling and aggregation	245	2.17e-10	4.54e-09	0.2480	0.009310	-0.248000	8.02e-01	2.54e-11
ATF6 (ATF6-alpha) activates chaperone genes	10	3.89e-01	4.83e-01	0.2470	0.184000	0.166000	3.15e-01	3.64e-01
TNF signaling	42	2.33e-02	5.00e-02	0.2470	0.097200	-0.227000	2.76e-01	1.08e-02
Recycling pathway of L1	27	8.75e-02	1.52e-01	0.2470	0.059400	-0.240000	5.93e-01	3.10e-02
FCGR3A-mediated phagocytosis	59	4.69e-03	1.28e-02	0.2460	-0.016700	-0.245000	8.25e-01	1.12e-03
Leishmania phagocytosis	59	4.69e-03	1.28e-02	0.2460	-0.016700	-0.245000	8.25e-01	1.12e-03
Parasite infection	59	4.69e-03	1.28e-02	0.2460	-0.016700	-0.245000	8.25e-01	1.12e-03
Scavenging by Class A Receptors	19	1.70e-01	2.53e-01	0.2460	-0.199000	-0.144000	1.33e-01	2.76e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	5.39e-02	1.02e-01	0.2460	0.243000	0.036000	1.73e-02	7.25e-01
Signaling by NTRK1 (TRKA)	115	4.22e-05	2.21e-04	0.2460	0.208000	-0.130000	1.16e-04	1.57e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.89e-02	7.73e-02	0.2460	-0.007980	0.245000	9.34e-01	1.08e-02
ABC transporter disorders	75	1.08e-03	3.71e-03	0.2450	0.050900	0.240000	4.46e-01	3.28e-04
Synthesis of PIPs at the plasma membrane	53	7.74e-03	1.99e-02	0.2450	-0.078900	-0.232000	3.21e-01	3.45e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling	40	2.59e-02	5.48e-02	0.2440	-0.097100	-0.224000	2.88e-01	1.42e-02
Citric acid cycle (TCA cycle)	22	1.36e-01	2.11e-01	0.2440	0.236000	0.063500	5.55e-02	6.06e-01
Neutrophil degranulation	453	2.68e-18	1.55e-16	0.2440	-0.107000	-0.220000	1.02e-04	1.36e-15
Pentose phosphate pathway	13	3.24e-01	4.20e-01	0.2440	-0.167000	0.178000	2.98e-01	2.66e-01
CDC42 GTPase cycle	150	1.41e-06	1.14e-05	0.2440	-0.062500	-0.236000	1.87e-01	6.43e-07
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	99	1.19e-04	5.50e-04	0.2440	0.164000	0.180000	4.74e-03	2.00e-03
Negative regulation of the PI3K/AKT network	106	7.40e-05	3.57e-04	0.2440	-0.054400	-0.237000	3.33e-01	2.42e-05
Degradation of cysteine and homocysteine	14	2.88e-01	3.82e-01	0.2440	0.007440	-0.244000	9.62e-01	1.15e-01
Regulation of KIT signaling	16	2.35e-01	3.30e-01	0.2440	-0.065500	-0.235000	6.50e-01	1.04e-01
Synthesis of PA	32	5.44e-02	1.03e-01	0.2430	-0.217000	-0.110000	3.33e-02	2.83e-01
FGFR2 ligand binding and activation	14	2.96e-01	3.90e-01	0.2430	0.223000	-0.096700	1.48e-01	5.31e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	2.80e-01	3.75e-01	0.2430	-0.141000	-0.198000	3.60e-01	2.01e-01
Diseases of hemostasis	14	2.80e-01	3.75e-01	0.2430	-0.141000	-0.198000	3.60e-01	2.01e-01
ZBP1(DAI) mediated induction of type I IFNs	21	1.62e-01	2.43e-01	0.2430	0.086400	-0.227000	4.93e-01	7.20e-02
Cardiac conduction	117	3.04e-05	1.68e-04	0.2430	-0.236000	-0.056100	1.05e-05	2.95e-01
Adrenaline,noradrenaline inhibits insulin secretion	23	1.34e-01	2.10e-01	0.2420	0.032700	-0.240000	7.86e-01	4.62e-02
Downstream signal transduction	29	8.30e-02	1.46e-01	0.2420	0.214000	-0.114000	4.60e-02	2.90e-01
Hedgehog ‘on’ state	82	6.10e-04	2.26e-03	0.2420	0.195000	0.143000	2.23e-03	2.50e-02
Bile acid and bile salt metabolism	44	1.89e-02	4.20e-02	0.2420	-0.209000	-0.123000	1.66e-02	1.58e-01
Diseases of mitotic cell cycle	38	3.55e-02	7.11e-02	0.2420	-0.002450	0.242000	9.79e-01	9.77e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	100	1.60e-04	7.10e-04	0.2420	0.005600	-0.242000	9.23e-01	2.90e-05
Toll Like Receptor 2 (TLR2) Cascade	100	1.60e-04	7.10e-04	0.2420	0.005600	-0.242000	9.23e-01	2.90e-05
Toll Like Receptor TLR1:TLR2 Cascade	100	1.60e-04	7.10e-04	0.2420	0.005600	-0.242000	9.23e-01	2.90e-05
Toll Like Receptor TLR6:TLR2 Cascade	100	1.60e-04	7.10e-04	0.2420	0.005600	-0.242000	9.23e-01	2.90e-05
Opioid Signalling	80	8.00e-04	2.85e-03	0.2420	-0.084200	-0.227000	1.93e-01	4.57e-04
SUMOylation	168	3.45e-07	3.29e-06	0.2420	0.078500	0.229000	7.94e-02	3.23e-07
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	3.37e-02	6.84e-02	0.2410	0.099200	0.220000	2.90e-01	1.89e-02
RHOB GTPase cycle	68	2.90e-03	8.64e-03	0.2410	0.053800	-0.235000	4.43e-01	8.00e-04
MAP kinase activation	63	4.60e-03	1.27e-02	0.2410	0.077700	-0.228000	2.87e-01	1.73e-03
Lewis blood group biosynthesis	15	2.65e-01	3.61e-01	0.2410	-0.233000	-0.061600	1.18e-01	6.80e-01
Interleukin-6 family signaling	22	1.58e-01	2.39e-01	0.2400	0.149000	-0.188000	2.26e-01	1.27e-01
PI3K/AKT Signaling in Cancer	98	2.24e-04	9.39e-04	0.2390	-0.025800	-0.238000	6.59e-01	4.88e-05
ADP signalling through P2Y purinoceptor 1	20	1.86e-01	2.72e-01	0.2390	0.066000	-0.230000	6.10e-01	7.55e-02
Activation of BH3-only proteins	30	7.94e-02	1.41e-01	0.2380	-0.028900	0.236000	7.84e-01	2.50e-02
GRB2 events in EGFR signaling	13	3.31e-01	4.27e-01	0.2380	-0.238000	-0.009300	1.38e-01	9.54e-01
SLC transporter disorders	96	3.88e-04	1.52e-03	0.2380	-0.167000	0.169000	4.71e-03	4.21e-03
Negative regulation of FGFR3 signaling	25	1.28e-01	2.03e-01	0.2380	0.147000	-0.186000	2.03e-01	1.07e-01
Regulation of TP53 Activity through Acetylation	30	7.76e-02	1.38e-01	0.2370	0.234000	0.039600	2.66e-02	7.07e-01
Metabolism of folate and pterines	16	2.64e-01	3.60e-01	0.2370	-0.060300	0.229000	6.76e-01	1.12e-01
G alpha (12/13) signalling events	74	2.01e-03	6.35e-03	0.2360	-0.025100	-0.235000	7.09e-01	4.79e-04
RUNX3 regulates p14-ARF	10	4.33e-01	5.24e-01	0.2360	0.236000	0.002390	1.96e-01	9.90e-01
Assembly Of The HIV Virion	16	2.72e-01	3.67e-01	0.2360	0.122000	-0.202000	3.98e-01	1.62e-01
Unblocking of NMDA receptors, glutamate binding and activation	21	1.83e-01	2.68e-01	0.2360	-0.151000	0.181000	2.30e-01	1.51e-01
Striated Muscle Contraction	32	6.41e-02	1.18e-01	0.2360	-0.175000	-0.159000	8.75e-02	1.20e-01
Formation of Incision Complex in GG-NER	41	3.02e-02	6.23e-02	0.2360	0.113000	0.207000	2.11e-01	2.18e-02
Signaling by TGFB family members	112	1.24e-04	5.71e-04	0.2350	0.204000	-0.117000	1.97e-04	3.20e-02
Miscellaneous substrates	12	3.78e-01	4.71e-01	0.2340	-0.230000	0.040200	1.67e-01	8.09e-01
Formation of apoptosome	11	4.14e-01	5.05e-01	0.2340	0.216000	-0.088900	2.14e-01	6.10e-01
Regulation of the apoptosome activity	11	4.14e-01	5.05e-01	0.2340	0.216000	-0.088900	2.14e-01	6.10e-01
Potassium Channels	96	5.03e-04	1.90e-03	0.2340	-0.154000	0.176000	9.34e-03	2.88e-03
Free fatty acids regulate insulin secretion	11	4.01e-01	4.95e-01	0.2330	-0.066300	-0.224000	7.04e-01	1.99e-01
Signaling by Retinoic Acid	42	3.32e-02	6.77e-02	0.2330	0.232000	-0.022800	9.22e-03	7.99e-01
SARS-CoV-2 modulates autophagy	11	4.07e-01	4.99e-01	0.2330	-0.006290	-0.233000	9.71e-01	1.81e-01
RHOC GTPase cycle	71	3.28e-03	9.55e-03	0.2330	0.035800	-0.230000	6.02e-01	7.92e-04
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	2.65e-02	5.59e-02	0.2330	0.231000	-0.033700	7.43e-03	6.96e-01
Methylation	14	3.29e-01	4.25e-01	0.2330	0.107000	-0.207000	4.87e-01	1.80e-01
Class B/2 (Secretin family receptors)	73	2.69e-03	8.17e-03	0.2320	0.232000	0.015300	6.16e-04	8.21e-01
RNA Polymerase III Transcription Initiation	36	5.35e-02	1.02e-01	0.2320	0.021700	0.231000	8.22e-01	1.63e-02
A tetrasaccharide linker sequence is required for GAG synthesis	26	1.24e-01	1.98e-01	0.2320	-0.231000	0.023500	4.14e-02	8.36e-01
Amino acids regulate mTORC1	52	1.69e-02	3.84e-02	0.2310	0.090000	-0.213000	2.62e-01	7.82e-03
Toll Like Receptor 7/8 (TLR7/8) Cascade	90	8.26e-04	2.94e-03	0.2310	0.055300	-0.225000	3.65e-01	2.30e-04
Activated NTRK2 signals through FRS2 and FRS3	11	4.04e-01	4.97e-01	0.2310	0.158000	0.169000	3.65e-01	3.33e-01
Transcriptional regulation by RUNX2	115	8.09e-05	3.89e-04	0.2310	0.159000	0.168000	3.30e-03	1.91e-03
p75NTR signals via NF-kB	16	2.88e-01	3.82e-01	0.2310	0.202000	-0.111000	1.62e-01	4.41e-01
Costimulation by the CD28 family	66	4.63e-03	1.27e-02	0.2310	-0.103000	-0.206000	1.49e-01	3.74e-03
Synthesis of PC	28	1.11e-01	1.82e-01	0.2300	0.050400	-0.225000	6.45e-01	3.96e-02
Golgi Associated Vesicle Biogenesis	55	1.45e-02	3.38e-02	0.2300	0.173000	-0.152000	2.65e-02	5.15e-02
NOTCH2 intracellular domain regulates transcription	11	4.09e-01	5.00e-01	0.2300	-0.108000	-0.203000	5.33e-01	2.44e-01
IL-6-type cytokine receptor ligand interactions	15	3.16e-01	4.11e-01	0.2300	0.173000	-0.151000	2.46e-01	3.11e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	20	2.02e-01	2.92e-01	0.2290	-0.221000	-0.060400	8.69e-02	6.40e-01
PCP/CE pathway	89	7.72e-04	2.79e-03	0.2290	0.130000	0.189000	3.42e-02	2.13e-03
Protein ubiquitination	63	7.00e-03	1.83e-02	0.2280	0.048100	0.223000	5.09e-01	2.22e-03
HCMV Infection	82	1.55e-03	5.15e-03	0.2280	0.079900	0.213000	2.11e-01	8.58e-04
ATF6 (ATF6-alpha) activates chaperones	12	3.85e-01	4.78e-01	0.2270	0.190000	0.124000	2.54e-01	4.56e-01
Transcriptional Regulation by TP53	348	1.65e-12	5.08e-11	0.2270	0.116000	0.195000	2.14e-04	4.07e-10
Glycerophospholipid biosynthesis	112	1.41e-04	6.41e-04	0.2270	-0.157000	-0.164000	4.16e-03	2.72e-03
Cytosolic iron-sulfur cluster assembly	11	4.18e-01	5.09e-01	0.2270	0.107000	0.200000	5.40e-01	2.50e-01
ADP signalling through P2Y purinoceptor 12	16	3.02e-01	3.96e-01	0.2270	0.176000	-0.143000	2.23e-01	3.22e-01
Adherens junctions interactions	26	1.36e-01	2.11e-01	0.2270	-0.226000	0.006280	4.57e-02	9.56e-01
RHOA GTPase cycle	143	1.66e-05	9.54e-05	0.2260	-0.042600	-0.222000	3.80e-01	4.65e-06
G-protein activation	17	2.82e-01	3.76e-01	0.2260	0.122000	-0.190000	3.85e-01	1.74e-01
Regulation of TP53 Expression and Degradation	37	5.47e-02	1.03e-01	0.2260	0.188000	0.126000	4.85e-02	1.85e-01
Fcgamma receptor (FCGR) dependent phagocytosis	84	1.52e-03	5.08e-03	0.2260	-0.059500	-0.218000	3.47e-01	5.67e-04
trans-Golgi Network Vesicle Budding	70	5.62e-03	1.50e-02	0.2260	0.120000	-0.191000	8.28e-02	5.74e-03
Cyclin D associated events in G1	46	2.72e-02	5.71e-02	0.2260	0.177000	0.139000	3.75e-02	1.02e-01
G1 Phase	46	2.72e-02	5.71e-02	0.2260	0.177000	0.139000	3.75e-02	1.02e-01
Uptake and actions of bacterial toxins	29	1.07e-01	1.77e-01	0.2250	-0.221000	-0.043900	3.95e-02	6.83e-01
MyD88 dependent cascade initiated on endosome	89	1.31e-03	4.43e-03	0.2250	0.061900	-0.217000	3.13e-01	4.17e-04
Aflatoxin activation and detoxification	19	2.27e-01	3.21e-01	0.2250	-0.190000	-0.121000	1.52e-01	3.63e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	88	1.43e-03	4.78e-03	0.2250	0.058500	-0.217000	3.43e-01	4.30e-04
Downstream signaling events of B Cell Receptor (BCR)	78	2.48e-03	7.61e-03	0.2250	0.074000	0.212000	2.59e-01	1.20e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	2.33e-01	3.27e-01	0.2250	0.217000	0.057200	1.01e-01	6.66e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	2.33e-01	3.27e-01	0.2250	0.217000	0.057200	1.01e-01	6.66e-01
Toll Like Receptor 4 (TLR4) Cascade	129	5.61e-05	2.80e-04	0.2250	-0.036100	-0.222000	4.80e-01	1.40e-05
Negative regulation of NMDA receptor-mediated neuronal transmission	21	2.14e-01	3.05e-01	0.2250	-0.186000	0.125000	1.40e-01	3.20e-01
Signaling by Erythropoietin	24	1.61e-01	2.43e-01	0.2240	-0.021000	-0.224000	8.58e-01	5.81e-02
Muscle contraction	179	1.07e-06	9.09e-06	0.2240	-0.183000	-0.129000	2.39e-05	2.91e-03
Platelet homeostasis	79	2.28e-03	7.12e-03	0.2240	-0.104000	-0.199000	1.10e-01	2.28e-03
Triglyceride metabolism	28	1.16e-01	1.87e-01	0.2240	-0.088100	-0.206000	4.20e-01	5.92e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.32e-01	3.26e-01	0.2240	-0.118000	0.190000	3.60e-01	1.41e-01
SUMO E3 ligases SUMOylate target proteins	162	5.04e-06	3.53e-05	0.2230	0.063600	0.214000	1.63e-01	2.69e-06
GPER1 signaling	37	6.50e-02	1.19e-01	0.2230	0.025100	-0.221000	7.91e-01	1.98e-02
SUMOylation of DNA methylation proteins	16	3.03e-01	3.97e-01	0.2230	0.019200	0.222000	8.94e-01	1.25e-01
Ketone body metabolism	10	4.66e-01	5.54e-01	0.2220	-0.164000	-0.150000	3.69e-01	4.11e-01
Degradation of the extracellular matrix	108	3.92e-04	1.53e-03	0.2220	-0.217000	0.048400	1.01e-04	3.85e-01
Purine salvage	13	3.89e-01	4.83e-01	0.2220	-0.074700	0.209000	6.41e-01	1.92e-01
Signaling by ERBB2	49	2.67e-02	5.64e-02	0.2220	-0.008630	-0.222000	9.17e-01	7.25e-03
Phospholipid metabolism	195	4.50e-07	4.18e-06	0.2220	-0.112000	-0.192000	7.30e-03	4.03e-06
Post NMDA receptor activation events	61	1.07e-02	2.59e-02	0.2210	-0.207000	-0.076100	5.11e-03	3.04e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	2.36e-01	3.31e-01	0.2200	-0.030800	0.218000	8.11e-01	9.11e-02
Loss of Nlp from mitotic centrosomes	66	8.10e-03	2.06e-02	0.2200	0.017800	0.220000	8.02e-01	2.04e-03
Loss of proteins required for interphase microtubule organization from the centrosome	66	8.10e-03	2.06e-02	0.2200	0.017800	0.220000	8.02e-01	2.04e-03
Budding and maturation of HIV virion	28	1.38e-01	2.13e-01	0.2200	0.117000	-0.187000	2.84e-01	8.74e-02
Signaling by FGFR	80	3.00e-03	8.89e-03	0.2200	0.220000	0.012800	6.84e-04	8.44e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.27e-01	2.01e-01	0.2200	0.069300	0.209000	5.26e-01	5.62e-02
Nephrin family interactions	22	2.05e-01	2.96e-01	0.2200	0.219000	-0.022700	7.60e-02	8.54e-01
Innate Immune System	941	2.78e-29	4.18e-27	0.2190	-0.105000	-0.192000	5.66e-08	3.30e-23
Signaling by VEGF	102	6.18e-04	2.29e-03	0.2190	-0.046300	-0.214000	4.19e-01	1.90e-04
Signaling by ERBB2 ECD mutants	15	3.36e-01	4.32e-01	0.2190	0.211000	0.058000	1.58e-01	6.97e-01
Gene expression (Transcription)	1384	2.23e-41	8.38e-39	0.2180	0.174000	0.131000	4.67e-27	6.55e-16
Dissolution of Fibrin Clot	13	4.06e-01	4.98e-01	0.2180	-0.187000	0.112000	2.42e-01	4.86e-01
Cargo recognition for clathrin-mediated endocytosis	101	8.83e-04	3.10e-03	0.2180	0.063900	-0.208000	2.68e-01	3.01e-04
Constitutive Signaling by AKT1 E17K in Cancer	25	1.78e-01	2.62e-01	0.2180	0.112000	-0.186000	3.31e-01	1.07e-01
HCMV Late Events	54	2.00e-02	4.37e-02	0.2180	0.088100	0.199000	2.63e-01	1.14e-02
PI Metabolism	84	2.47e-03	7.60e-03	0.2180	-0.041100	-0.214000	5.16e-01	7.18e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	7.18e-02	1.30e-01	0.2170	0.216000	0.023800	2.30e-02	8.02e-01
RAF activation	34	9.68e-02	1.63e-01	0.2170	0.179000	-0.124000	7.16e-02	2.12e-01
Interconversion of nucleotide di- and triphosphates	27	1.51e-01	2.29e-01	0.2170	-0.016900	0.216000	8.79e-01	5.21e-02
Signaling by CSF3 (G-CSF)	28	1.46e-01	2.23e-01	0.2170	0.095000	-0.195000	3.84e-01	7.46e-02
Toll Like Receptor 9 (TLR9) Cascade	92	1.76e-03	5.70e-03	0.2170	0.059100	-0.208000	3.27e-01	5.56e-04
Thromboxane signalling through TP receptor	19	2.73e-01	3.68e-01	0.2160	0.119000	-0.181000	3.70e-01	1.72e-01
activated TAK1 mediates p38 MAPK activation	19	2.55e-01	3.50e-01	0.2160	-0.184000	-0.114000	1.65e-01	3.90e-01
Signaling by Activin	15	3.56e-01	4.51e-01	0.2160	0.206000	-0.064900	1.67e-01	6.64e-01
MyD88 cascade initiated on plasma membrane	84	3.31e-03	9.57e-03	0.2160	0.081900	-0.199000	1.94e-01	1.59e-03
Toll Like Receptor 10 (TLR10) Cascade	84	3.31e-03	9.57e-03	0.2160	0.081900	-0.199000	1.94e-01	1.59e-03
Toll Like Receptor 5 (TLR5) Cascade	84	3.31e-03	9.57e-03	0.2160	0.081900	-0.199000	1.94e-01	1.59e-03
Energy dependent regulation of mTOR by LKB1-AMPK	29	1.32e-01	2.07e-01	0.2150	-0.023600	-0.214000	8.26e-01	4.61e-02
G beta:gamma signalling through BTK	13	4.10e-01	5.01e-01	0.2150	0.047600	-0.210000	7.67e-01	1.90e-01
RNA Polymerase II Transcription	1251	9.96e-37	2.50e-34	0.2150	0.185000	0.110000	1.20e-27	7.75e-11
Toll Like Receptor 3 (TLR3) Cascade	93	1.87e-03	5.99e-03	0.2150	0.090800	-0.195000	1.30e-01	1.16e-03
Constitutive Signaling by EGFRvIII	15	3.46e-01	4.42e-01	0.2150	0.201000	0.075500	1.77e-01	6.13e-01
Signaling by EGFRvIII in Cancer	15	3.46e-01	4.42e-01	0.2150	0.201000	0.075500	1.77e-01	6.13e-01
Signaling by NOTCH4	80	3.44e-03	9.90e-03	0.2150	0.152000	0.151000	1.86e-02	1.94e-02
Iron uptake and transport	57	2.22e-02	4.81e-02	0.2140	0.125000	-0.174000	1.03e-01	2.31e-02
CaMK IV-mediated phosphorylation of CREB	10	5.04e-01	5.91e-01	0.2140	-0.214000	0.016300	2.42e-01	9.29e-01
Ovarian tumor domain proteases	39	7.20e-02	1.30e-01	0.2140	0.057800	-0.206000	5.32e-01	2.61e-02
Regulation of PTEN gene transcription	61	1.40e-02	3.28e-02	0.2140	0.195000	0.088400	8.54e-03	2.33e-01
Disorders of transmembrane transporters	171	1.14e-05	6.89e-05	0.2140	-0.071700	0.201000	1.06e-01	5.73e-06
Toll-like Receptor Cascades	149	3.58e-05	1.91e-04	0.2140	-0.041200	-0.210000	3.86e-01	1.02e-05
Endosomal Sorting Complex Required For Transport (ESCRT)	31	1.29e-01	2.03e-01	0.2130	0.147000	-0.155000	1.57e-01	1.36e-01
ISG15 antiviral mechanism	71	8.19e-03	2.08e-02	0.2110	0.050900	0.205000	4.59e-01	2.82e-03
Nicotinate metabolism	25	1.85e-01	2.71e-01	0.2110	-0.032600	-0.209000	7.78e-01	7.10e-02
FLT3 Signaling	38	8.24e-02	1.45e-01	0.2110	0.052400	-0.204000	5.76e-01	2.93e-02
MyD88-independent TLR4 cascade	96	2.00e-03	6.35e-03	0.2110	0.081600	-0.194000	1.67e-01	1.02e-03
TRIF(TICAM1)-mediated TLR4 signaling	96	2.00e-03	6.35e-03	0.2110	0.081600	-0.194000	1.67e-01	1.02e-03
Gap junction trafficking	25	1.94e-01	2.82e-01	0.2100	-0.033000	0.208000	7.75e-01	7.26e-02
Trafficking and processing of endosomal TLR	13	4.19e-01	5.09e-01	0.2100	-0.052600	-0.203000	7.42e-01	2.05e-01
Signal amplification	27	1.78e-01	2.62e-01	0.2100	0.131000	-0.164000	2.39e-01	1.41e-01
Netrin-1 signaling	49	3.70e-02	7.39e-02	0.2090	-0.142000	-0.154000	8.63e-02	6.31e-02
TICAM1-dependent activation of IRF3/IRF7	12	4.60e-01	5.49e-01	0.2090	0.205000	-0.038900	2.18e-01	8.16e-01
RHOBTB3 ATPase cycle	10	5.34e-01	6.18e-01	0.2070	-0.115000	0.172000	5.28e-01	3.46e-01
Zinc transporters	14	4.01e-01	4.95e-01	0.2070	0.050000	0.201000	7.46e-01	1.93e-01
HSF1-dependent transactivation	33	1.13e-01	1.84e-01	0.2070	0.128000	0.163000	2.04e-01	1.06e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	14	4.06e-01	4.98e-01	0.2070	0.207000	0.011500	1.81e-01	9.41e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	3.05e-01	3.99e-01	0.2070	-0.139000	-0.153000	3.08e-01	2.60e-01
DAP12 signaling	29	1.48e-01	2.25e-01	0.2070	-0.142000	-0.150000	1.85e-01	1.62e-01
Lysine catabolism	12	4.74e-01	5.63e-01	0.2070	0.111000	-0.174000	5.05e-01	2.97e-01
Regulation of insulin secretion	71	9.56e-03	2.38e-02	0.2060	-0.137000	-0.155000	4.67e-02	2.44e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	4.44e-01	5.35e-01	0.2060	0.194000	-0.068400	2.25e-01	6.70e-01
PTEN Regulation	138	1.25e-04	5.75e-04	0.2060	0.149000	0.142000	2.56e-03	3.89e-03
NOTCH4 Intracellular Domain Regulates Transcription	19	2.99e-01	3.93e-01	0.2060	-0.009690	-0.205000	9.42e-01	1.21e-01
VEGFA-VEGFR2 Pathway	94	2.53e-03	7.74e-03	0.2060	-0.025500	-0.204000	6.70e-01	6.32e-04
Termination of translesion DNA synthesis	31	1.35e-01	2.11e-01	0.2060	0.067900	0.194000	5.13e-01	6.16e-02
Activation of AMPK downstream of NMDARs	10	5.22e-01	6.09e-01	0.2060	-0.181000	-0.097100	3.21e-01	5.95e-01
Signaling by NTRKs	134	2.89e-04	1.18e-03	0.2050	0.146000	-0.144000	3.55e-03	4.00e-03
FLT3 signaling in disease	28	1.79e-01	2.64e-01	0.2050	0.177000	-0.104000	1.05e-01	3.42e-01
Fatty acids	15	3.93e-01	4.88e-01	0.2050	-0.201000	0.036700	1.77e-01	8.05e-01
Arachidonic acid metabolism	54	3.09e-02	6.37e-02	0.2050	-0.111000	-0.172000	1.57e-01	2.91e-02
Platelet Adhesion to exposed collagen	12	4.60e-01	5.49e-01	0.2050	-0.127000	-0.161000	4.48e-01	3.35e-01
Generic Transcription Pathway	1135	2.59e-30	4.32e-28	0.2050	0.185000	0.086700	1.58e-25	1.05e-06
Constitutive Signaling by Overexpressed ERBB2	10	5.26e-01	6.11e-01	0.2040	0.178000	0.099900	3.29e-01	5.84e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	1.71e-01	2.54e-01	0.2040	-0.046400	-0.198000	6.71e-01	6.91e-02
Signaling by MET	67	1.42e-02	3.32e-02	0.2040	-0.092200	-0.182000	1.92e-01	1.02e-02
Regulation of PLK1 Activity at G2/M Transition	84	5.16e-03	1.39e-02	0.2030	0.049300	0.197000	4.35e-01	1.78e-03
Serotonin Neurotransmitter Release Cycle	17	3.49e-01	4.44e-01	0.2030	-0.203000	-0.003130	1.47e-01	9.82e-01
Nuclear Receptor transcription pathway	52	4.13e-02	8.15e-02	0.2030	0.021500	-0.202000	7.88e-01	1.18e-02
Rab regulation of trafficking	120	6.16e-04	2.28e-03	0.2030	-0.017100	-0.202000	7.46e-01	1.33e-04
FCERI mediated NF-kB activation	75	9.29e-03	2.32e-02	0.2020	0.070300	0.190000	2.93e-01	4.52e-03
AKT phosphorylates targets in the cytosol	14	4.29e-01	5.20e-01	0.2020	0.052100	-0.195000	7.36e-01	2.06e-01
Clathrin-mediated endocytosis	139	2.67e-04	1.11e-03	0.2010	0.063900	-0.191000	1.94e-01	1.04e-04
Regulation of PTEN mRNA translation	11	5.24e-01	6.09e-01	0.2010	0.156000	-0.127000	3.70e-01	4.67e-01
Signaling by FGFR3	36	1.19e-01	1.91e-01	0.2010	0.184000	-0.081200	5.65e-02	3.99e-01
Nucleotide catabolism	33	1.45e-01	2.21e-01	0.2010	-0.169000	0.109000	9.38e-02	2.80e-01
Regulation of TP53 Degradation	36	1.08e-01	1.78e-01	0.2000	0.169000	0.107000	7.91e-02	2.65e-01
DNA Double Strand Break Response	43	7.02e-02	1.27e-01	0.2000	0.114000	0.165000	1.96e-01	6.16e-02
PI3K Cascade	38	1.11e-01	1.82e-01	0.1990	0.109000	-0.167000	2.44e-01	7.56e-02
Recruitment of NuMA to mitotic centrosomes	77	1.05e-02	2.56e-02	0.1990	-0.004830	0.199000	9.42e-01	2.54e-03
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	4.68e-01	5.57e-01	0.1990	0.063000	-0.189000	6.94e-01	2.39e-01
Purine catabolism	16	3.83e-01	4.77e-01	0.1980	0.048100	0.193000	7.39e-01	1.82e-01
RHO GTPases Activate WASPs and WAVEs	36	1.26e-01	2.01e-01	0.1980	0.096400	-0.173000	3.17e-01	7.18e-02
FCERI mediated MAPK activation	29	1.72e-01	2.55e-01	0.1980	-0.167000	-0.107000	1.20e-01	3.18e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	3.19e-01	4.14e-01	0.1980	0.085800	0.178000	5.17e-01	1.78e-01
Regulation of actin dynamics for phagocytic cup formation	61	2.78e-02	5.83e-02	0.1980	-0.016600	-0.197000	8.22e-01	7.83e-03
SHC-mediated cascade:FGFR3	14	4.46e-01	5.37e-01	0.1980	-0.051700	0.191000	7.38e-01	2.17e-01
Platelet sensitization by LDL	16	4.03e-01	4.96e-01	0.1970	0.112000	-0.162000	4.36e-01	2.61e-01
Centrosome maturation	78	1.09e-02	2.64e-02	0.1970	-0.014400	0.197000	8.26e-01	2.67e-03
Recruitment of mitotic centrosome proteins and complexes	78	1.09e-02	2.64e-02	0.1970	-0.014400	0.197000	8.26e-01	2.67e-03
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	16	3.96e-01	4.90e-01	0.1970	0.196000	-0.019300	1.75e-01	8.93e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	4.35e-01	5.25e-01	0.1970	0.177000	0.085100	2.50e-01	5.81e-01
Azathioprine ADME	22	2.81e-01	3.76e-01	0.1970	-0.017400	0.196000	8.87e-01	1.12e-01
Heme signaling	46	6.94e-02	1.26e-01	0.1960	-0.014800	-0.196000	8.62e-01	2.16e-02
Deadenylation of mRNA	24	2.48e-01	3.43e-01	0.1960	0.018800	0.195000	8.73e-01	9.75e-02
Regulation of RUNX1 Expression and Activity	17	3.76e-01	4.71e-01	0.1960	0.011700	-0.196000	9.34e-01	1.62e-01
TGF-beta receptor signaling activates SMADs	45	8.08e-02	1.42e-01	0.1960	0.113000	-0.160000	1.91e-01	6.27e-02
IKK complex recruitment mediated by RIP1	22	2.84e-01	3.78e-01	0.1950	-0.008400	-0.195000	9.46e-01	1.13e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	5.28e-01	6.12e-01	0.1950	-0.186000	-0.057400	2.84e-01	7.42e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.25e-01	2.00e-01	0.1950	0.185000	0.060200	5.47e-02	5.32e-01
NRAGE signals death through JNK	58	3.43e-02	6.96e-02	0.1940	-0.109000	-0.161000	1.51e-01	3.40e-02
The citric acid (TCA) cycle and respiratory electron transport	148	1.98e-04	8.51e-04	0.1940	0.137000	0.137000	4.02e-03	4.05e-03
Signaling by EGFR	50	6.49e-02	1.19e-01	0.1930	0.082800	-0.175000	3.11e-01	3.26e-02
Carboxyterminal post-translational modifications of tubulin	37	1.18e-01	1.90e-01	0.1930	-0.143000	-0.130000	1.32e-01	1.71e-01
DNA Damage Recognition in GG-NER	38	1.12e-01	1.83e-01	0.1930	0.162000	0.105000	8.35e-02	2.63e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	102	3.27e-03	9.55e-03	0.1930	-0.192000	-0.019800	7.99e-04	7.30e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.16e-01	5.07e-01	0.1930	0.066200	-0.181000	6.47e-01	2.09e-01
Glycogen breakdown (glycogenolysis)	15	4.24e-01	5.14e-01	0.1930	0.160000	0.107000	2.82e-01	4.74e-01
Fatty acid metabolism	156	1.77e-04	7.75e-04	0.1920	-0.022000	-0.191000	6.36e-01	3.89e-05
Laminin interactions	23	2.78e-01	3.73e-01	0.1910	-0.184000	-0.050400	1.26e-01	6.76e-01
Signaling by Non-Receptor Tyrosine Kinases	54	5.61e-02	1.05e-01	0.1910	0.067100	-0.178000	3.94e-01	2.33e-02
Signaling by PTK6	54	5.61e-02	1.05e-01	0.1910	0.067100	-0.178000	3.94e-01	2.33e-02
Triglyceride catabolism	18	3.67e-01	4.61e-01	0.1910	-0.081100	-0.172000	5.52e-01	2.05e-01
FGFR1 mutant receptor activation	26	2.50e-01	3.46e-01	0.1900	0.057200	-0.181000	6.14e-01	1.10e-01
Deactivation of the beta-catenin transactivating complex	41	1.09e-01	1.79e-01	0.1900	0.189000	0.012200	3.60e-02	8.93e-01
Endogenous sterols	25	2.51e-01	3.46e-01	0.1890	-0.142000	-0.125000	2.18e-01	2.80e-01
TRAF6 mediated NF-kB activation	25	2.69e-01	3.64e-01	0.1890	0.069800	-0.176000	5.46e-01	1.28e-01
CYP2E1 reactions	11	5.46e-01	6.30e-01	0.1890	-0.165000	-0.091800	3.43e-01	5.98e-01
HATs acetylate histones	74	1.98e-02	4.34e-02	0.1880	0.188000	-0.001590	5.10e-03	9.81e-01
Regulation of innate immune responses to cytosolic DNA	14	4.85e-01	5.73e-01	0.1880	0.154000	-0.108000	3.19e-01	4.82e-01
Synthesis of PE	12	5.28e-01	6.12e-01	0.1880	-0.001910	-0.188000	9.91e-01	2.59e-01
Golgi-to-ER retrograde transport	113	2.56e-03	7.78e-03	0.1880	0.012800	0.187000	8.14e-01	5.84e-04
Cholesterol biosynthesis	25	2.77e-01	3.72e-01	0.1880	0.139000	-0.127000	2.30e-01	2.73e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	3.66e-01	4.61e-01	0.1880	-0.003540	-0.188000	9.79e-01	1.57e-01
Unfolded Protein Response (UPR)	85	1.05e-02	2.56e-02	0.1870	0.158000	0.100000	1.20e-02	1.10e-01
Common Pathway of Fibrin Clot Formation	20	3.42e-01	4.39e-01	0.1870	-0.146000	-0.116000	2.58e-01	3.70e-01
Integration of energy metabolism	100	4.81e-03	1.31e-02	0.1860	-0.115000	-0.147000	4.70e-02	1.13e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	42	1.06e-01	1.75e-01	0.1860	0.116000	0.146000	1.95e-01	1.02e-01
Tryptophan catabolism	12	5.38e-01	6.22e-01	0.1860	-0.186000	0.014100	2.66e-01	9.33e-01
Activation of NMDA receptors and postsynaptic events	74	2.04e-02	4.45e-02	0.1860	-0.174000	-0.064800	9.63e-03	3.35e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	26	2.67e-01	3.63e-01	0.1850	0.046700	-0.179000	6.80e-01	1.13e-01
Transport of vitamins, nucleosides, and related molecules	38	1.35e-01	2.11e-01	0.1850	-0.163000	-0.087800	8.17e-02	3.49e-01
Transferrin endocytosis and recycling	30	2.23e-01	3.16e-01	0.1850	0.062200	-0.174000	5.56e-01	9.96e-02
CTLA4 inhibitory signaling	21	3.40e-01	4.36e-01	0.1840	-0.024600	-0.183000	8.45e-01	1.47e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	21	3.43e-01	4.39e-01	0.1840	0.184000	0.001910	1.44e-01	9.88e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	24	2.92e-01	3.86e-01	0.1840	-0.033900	-0.181000	7.74e-01	1.25e-01
Activation of kainate receptors upon glutamate binding	25	2.75e-01	3.70e-01	0.1840	-0.175000	-0.057200	1.30e-01	6.20e-01
Integrin cell surface interactions	64	3.84e-02	7.65e-02	0.1840	-0.032300	-0.181000	6.55e-01	1.24e-02
Diseases associated with visual transduction	12	5.50e-01	6.31e-01	0.1830	-0.180000	0.034100	2.80e-01	8.38e-01
Diseases of the neuronal system	12	5.50e-01	6.31e-01	0.1830	-0.180000	0.034100	2.80e-01	8.38e-01
Retinoid cycle disease events	12	5.50e-01	6.31e-01	0.1830	-0.180000	0.034100	2.80e-01	8.38e-01
Signaling by TGF-beta Receptor Complex	87	1.45e-02	3.38e-02	0.1830	0.149000	-0.106000	1.63e-02	8.69e-02
G beta:gamma signalling through CDC42	15	4.81e-01	5.69e-01	0.1830	0.120000	-0.138000	4.21e-01	3.54e-01
Potential therapeutics for SARS	86	1.33e-02	3.15e-02	0.1830	0.183000	0.011000	3.43e-03	8.60e-01
Sensory processing of sound by outer hair cells of the cochlea	49	8.19e-02	1.44e-01	0.1830	-0.163000	-0.081500	4.81e-02	3.24e-01
COPI-mediated anterograde transport	81	1.71e-02	3.88e-02	0.1820	0.178000	0.037100	5.51e-03	5.64e-01
Cell surface interactions at the vascular wall	129	1.46e-03	4.88e-03	0.1820	-0.165000	-0.078100	1.25e-03	1.26e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	5.05e-01	5.93e-01	0.1820	0.065100	-0.170000	6.73e-01	2.70e-01
ABC-family proteins mediated transport	99	8.24e-03	2.08e-02	0.1810	-0.020800	0.180000	7.21e-01	2.02e-03
Neuronal System	370	2.87e-08	3.57e-07	0.1810	-0.165000	0.073300	5.16e-08	1.57e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	6.24e-01	6.92e-01	0.1800	0.126000	-0.129000	4.90e-01	4.80e-01
SLC-mediated transmembrane transport	226	1.97e-05	1.12e-04	0.1790	-0.179000	-0.015100	3.74e-06	6.97e-01
Basigin interactions	25	3.10e-01	4.06e-01	0.1790	-0.118000	0.135000	3.06e-01	2.43e-01
Metabolic disorders of biological oxidation enzymes	33	2.12e-01	3.03e-01	0.1790	-0.076900	0.162000	4.45e-01	1.07e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	5.26e-01	6.11e-01	0.1790	-0.097800	-0.150000	5.41e-01	3.49e-01
Association of TriC/CCT with target proteins during biosynthesis	39	1.47e-01	2.23e-01	0.1790	0.120000	0.132000	1.94e-01	1.53e-01
Signaling by PDGFRA extracellular domain mutants	12	5.57e-01	6.38e-01	0.1780	0.068100	0.165000	6.83e-01	3.23e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	5.57e-01	6.38e-01	0.1780	0.068100	0.165000	6.83e-01	3.23e-01
Peroxisomal protein import	61	5.41e-02	1.02e-01	0.1780	-0.019300	-0.177000	7.94e-01	1.67e-02
Transcriptional regulation by RUNX3	95	9.72e-03	2.41e-02	0.1780	0.142000	0.107000	1.66e-02	7.11e-02
Glycogen synthesis	16	4.60e-01	5.49e-01	0.1770	0.149000	0.095900	3.01e-01	5.07e-01
RHO GTPases activate IQGAPs	11	6.04e-01	6.76e-01	0.1770	0.112000	-0.137000	5.20e-01	4.30e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	5.97e-01	6.69e-01	0.1770	0.012400	-0.177000	9.43e-01	3.10e-01
Signaling by WNT	258	5.42e-06	3.72e-05	0.1770	0.169000	0.051500	3.02e-06	1.55e-01
TP53 Regulates Transcription of Cell Death Genes	42	1.41e-01	2.18e-01	0.1760	0.176000	-0.004780	4.80e-02	9.57e-01
Interleukin-35 Signalling	11	6.09e-01	6.81e-01	0.1760	0.087700	-0.152000	6.15e-01	3.82e-01
RAB GEFs exchange GTP for GDP on RABs	87	1.89e-02	4.20e-02	0.1740	-0.032500	-0.171000	6.01e-01	5.94e-03
RHO GTPases activate PKNs	33	2.33e-01	3.27e-01	0.1740	0.160000	-0.067300	1.12e-01	5.04e-01
Repression of WNT target genes	13	5.62e-01	6.41e-01	0.1740	0.164000	-0.056500	3.06e-01	7.25e-01
RHO GTPases activate KTN1	11	6.18e-01	6.87e-01	0.1730	0.144000	-0.095900	4.07e-01	5.82e-01
Amyloid fiber formation	46	1.27e-01	2.01e-01	0.1730	0.006330	-0.173000	9.41e-01	4.23e-02
IRAK1 recruits IKK complex	10	6.30e-01	6.96e-01	0.1730	-0.148000	-0.089400	4.17e-01	6.25e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	6.30e-01	6.96e-01	0.1730	-0.148000	-0.089400	4.17e-01	6.25e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	4.02e-01	4.95e-01	0.1720	0.091500	-0.146000	4.68e-01	2.46e-01
Chemokine receptors bind chemokines	50	1.05e-01	1.75e-01	0.1720	-0.038600	-0.168000	6.37e-01	4.00e-02
Metabolism of steroid hormones	30	2.72e-01	3.68e-01	0.1720	-0.150000	0.085300	1.56e-01	4.19e-01
RHO GTPase cycle	434	6.43e-09	9.77e-08	0.1720	-0.003020	-0.172000	9.14e-01	8.51e-10
RHOJ GTPase cycle	55	8.81e-02	1.53e-01	0.1720	0.013600	-0.172000	8.61e-01	2.77e-02
Amino acid transport across the plasma membrane	32	2.48e-01	3.43e-01	0.1720	-0.162000	0.059600	1.14e-01	5.59e-01
Immune System	1789	2.50e-32	5.37e-30	0.1720	-0.092000	-0.145000	1.94e-10	1.04e-23
Signaling by Insulin receptor	70	4.95e-02	9.59e-02	0.1710	0.060200	-0.160000	3.84e-01	2.05e-02
Receptor-type tyrosine-protein phosphatases	20	4.20e-01	5.11e-01	0.1710	-0.167000	0.035900	1.95e-01	7.81e-01
Sensory processing of sound	70	4.50e-02	8.81e-02	0.1700	-0.157000	-0.065500	2.30e-02	3.43e-01
SARS-CoV-1 Infection	52	1.10e-01	1.81e-01	0.1700	0.058500	-0.160000	4.66e-01	4.65e-02
Sensory processing of sound by inner hair cells of the cochlea	63	6.29e-02	1.16e-01	0.1700	-0.159000	-0.060300	2.96e-02	4.08e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	5.23e-01	6.09e-01	0.1690	-0.032400	-0.166000	8.28e-01	2.67e-01
IRF3-mediated induction of type I IFN	11	6.30e-01	6.96e-01	0.1690	-0.042100	0.163000	8.09e-01	3.48e-01
RHOV GTPase cycle	37	2.17e-01	3.08e-01	0.1680	0.155000	-0.065400	1.04e-01	4.91e-01
PECAM1 interactions	11	6.21e-01	6.90e-01	0.1680	-0.150000	-0.076100	3.91e-01	6.62e-01
Neddylation	219	8.39e-05	4.02e-04	0.1680	0.092200	0.140000	1.89e-02	3.58e-04
Dopamine Neurotransmitter Release Cycle	22	3.96e-01	4.90e-01	0.1680	-0.168000	0.005650	1.73e-01	9.63e-01
Transcriptional regulation of white adipocyte differentiation	82	3.44e-02	6.96e-02	0.1680	0.154000	-0.067100	1.62e-02	2.94e-01
Signaling by FLT3 ITD and TKD mutants	16	5.20e-01	6.06e-01	0.1680	0.139000	-0.093300	3.35e-01	5.18e-01
Receptor Mediated Mitophagy	11	6.35e-01	7.01e-01	0.1660	-0.012200	0.166000	9.44e-01	3.41e-01
Chondroitin sulfate biosynthesis	19	4.46e-01	5.37e-01	0.1660	0.135000	0.096700	3.08e-01	4.66e-01
Ub-specific processing proteases	158	1.29e-03	4.39e-03	0.1660	0.143000	0.084100	1.92e-03	6.84e-02
Cellular response to starvation	149	2.00e-03	6.35e-03	0.1660	0.052700	0.157000	2.67e-01	9.30e-04
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	52	1.13e-01	1.84e-01	0.1660	-0.055300	-0.156000	4.91e-01	5.13e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	5.56e-01	6.37e-01	0.1660	-0.061200	-0.154000	6.92e-01	3.19e-01
Phenylalanine and tyrosine metabolism	10	6.64e-01	7.25e-01	0.1650	-0.165000	0.012500	3.66e-01	9.45e-01
TRAF3-dependent IRF activation pathway	14	5.69e-01	6.46e-01	0.1650	0.158000	-0.048200	3.06e-01	7.55e-01
Downregulation of TGF-beta receptor signaling	26	3.56e-01	4.51e-01	0.1650	0.118000	-0.115000	2.96e-01	3.09e-01
RA biosynthesis pathway	22	4.08e-01	5.00e-01	0.1650	0.165000	0.004130	1.81e-01	9.73e-01
Chromatin modifying enzymes	193	3.54e-04	1.40e-03	0.1640	0.135000	0.093500	1.24e-03	2.52e-02
Chromatin organization	193	3.54e-04	1.40e-03	0.1640	0.135000	0.093500	1.24e-03	2.52e-02
Intrinsic Pathway for Apoptosis	53	1.11e-01	1.82e-01	0.1640	0.102000	0.128000	1.98e-01	1.06e-01
Regulation of signaling by CBL	18	4.77e-01	5.66e-01	0.1640	-0.070900	-0.147000	6.03e-01	2.79e-01
Chaperone Mediated Autophagy	20	4.60e-01	5.49e-01	0.1630	0.063600	-0.150000	6.23e-01	2.46e-01
WNT5A-dependent internalization of FZD4	15	5.61e-01	6.41e-01	0.1620	0.142000	-0.079000	3.42e-01	5.96e-01
RHOQ GTPase cycle	59	9.90e-02	1.66e-01	0.1620	0.012400	-0.162000	8.69e-01	3.17e-02
RNA Polymerase III Abortive And Retractive Initiation	41	1.91e-01	2.79e-01	0.1620	0.081300	0.140000	3.68e-01	1.21e-01
RNA Polymerase III Transcription	41	1.91e-01	2.79e-01	0.1620	0.081300	0.140000	3.68e-01	1.21e-01
SHC1 events in EGFR signaling	14	5.80e-01	6.55e-01	0.1620	-0.160000	0.027300	3.01e-01	8.60e-01
SHC-mediated cascade:FGFR1	16	5.27e-01	6.11e-01	0.1620	0.152000	0.055400	2.92e-01	7.02e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	5.03e-01	5.91e-01	0.1620	-0.107000	-0.121000	4.46e-01	3.86e-01
FOXO-mediated transcription	61	9.94e-02	1.66e-01	0.1610	0.134000	-0.090200	7.08e-02	2.23e-01
Hemostasis	547	7.03e-10	1.37e-08	0.1610	-0.058000	-0.150000	2.09e-02	2.04e-09
Metabolism of amino acids and derivatives	340	2.72e-06	2.07e-05	0.1610	-0.025100	0.159000	4.27e-01	5.13e-07
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	16	5.48e-01	6.31e-01	0.1600	0.139000	-0.079900	3.36e-01	5.80e-01
Na+/Cl- dependent neurotransmitter transporters	16	5.46e-01	6.30e-01	0.1600	-0.151000	0.054300	2.96e-01	7.07e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	3.28e-07	3.16e-06	0.1600	0.125000	-0.100000	1.55e-05	5.16e-04
Ca2+ pathway	57	1.11e-01	1.82e-01	0.1600	-0.022100	-0.158000	7.73e-01	3.87e-02
Cytochrome P450 - arranged by substrate type	62	8.89e-02	1.54e-01	0.1600	-0.148000	-0.061000	4.43e-02	4.07e-01
Death Receptor Signalling	137	5.82e-03	1.55e-02	0.1600	0.029800	-0.157000	5.47e-01	1.54e-03
RHOBTB GTPase Cycle	35	2.53e-01	3.48e-01	0.1600	0.128000	0.094900	1.89e-01	3.31e-01
MET activates RAS signaling	11	6.64e-01	7.25e-01	0.1600	-0.081800	0.137000	6.38e-01	4.31e-01
Signaling by SCF-KIT	43	1.93e-01	2.81e-01	0.1590	-0.022200	-0.158000	8.01e-01	7.38e-02
SHC-mediated cascade:FGFR2	17	5.19e-01	6.06e-01	0.1590	0.151000	0.048800	2.80e-01	7.28e-01
Glutamate and glutamine metabolism	13	6.05e-01	6.76e-01	0.1590	0.148000	0.058900	3.57e-01	7.13e-01
Mitochondrial Fatty Acid Beta-Oxidation	33	2.85e-01	3.79e-01	0.1590	-0.023500	-0.157000	8.15e-01	1.19e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	3.34e-01	4.30e-01	0.1590	0.115000	-0.109000	2.76e-01	3.01e-01
Translation of Structural Proteins	29	3.31e-01	4.27e-01	0.1580	-0.049800	-0.150000	6.42e-01	1.62e-01
Formation of Fibrin Clot (Clotting Cascade)	35	2.62e-01	3.58e-01	0.1580	-0.121000	-0.101000	2.16e-01	3.01e-01
Metabolism of lipids	675	2.44e-11	6.12e-10	0.1570	-0.046900	-0.150000	3.90e-02	3.77e-11
NRIF signals cell death from the nucleus	16	5.60e-01	6.40e-01	0.1570	0.049000	-0.149000	7.35e-01	3.02e-01
RHOBTB1 GTPase cycle	23	4.22e-01	5.11e-01	0.1570	0.142000	0.064900	2.37e-01	5.90e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	55	1.35e-01	2.11e-01	0.1560	0.155000	-0.019700	4.65e-02	8.00e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	55	1.35e-01	2.11e-01	0.1560	0.155000	-0.019700	4.65e-02	8.00e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	55	1.35e-01	2.11e-01	0.1560	0.155000	-0.019700	4.65e-02	8.00e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	55	1.35e-01	2.11e-01	0.1560	0.155000	-0.019700	4.65e-02	8.00e-01
Signaling by NOTCH1 in Cancer	55	1.35e-01	2.11e-01	0.1560	0.155000	-0.019700	4.65e-02	8.00e-01
Metabolism of porphyrins	27	3.70e-01	4.64e-01	0.1560	-0.156000	-0.011100	1.61e-01	9.20e-01
Gap junction trafficking and regulation	27	3.79e-01	4.72e-01	0.1560	-0.025100	0.153000	8.21e-01	1.68e-01
Neurotransmitter receptors and postsynaptic signal transmission	169	2.56e-03	7.78e-03	0.1550	-0.151000	0.034000	6.96e-04	4.47e-01
Sema3A PAK dependent Axon repulsion	16	5.56e-01	6.37e-01	0.1550	-0.146000	-0.052400	3.13e-01	7.17e-01
L1CAM interactions	97	2.93e-02	6.10e-02	0.1550	-0.144000	-0.055300	1.41e-02	3.47e-01
PKMTs methylate histone lysines	39	2.41e-01	3.35e-01	0.1540	0.067000	0.139000	4.69e-01	1.33e-01
Leishmania infection	211	5.09e-04	1.92e-03	0.1540	-0.050700	-0.146000	2.05e-01	2.70e-04
Miscellaneous transport and binding events	23	4.46e-01	5.37e-01	0.1540	-0.150000	0.036500	2.14e-01	7.62e-01
Post-translational modification: synthesis of GPI-anchored proteins	81	5.53e-02	1.04e-01	0.1540	-0.151000	-0.028000	1.87e-02	6.64e-01
Signaling by NODAL	17	5.50e-01	6.31e-01	0.1540	0.153000	-0.018200	2.76e-01	8.97e-01
Plasma lipoprotein assembly, remodeling, and clearance	68	9.35e-02	1.59e-01	0.1540	0.031100	-0.150000	6.57e-01	3.20e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	28	3.69e-01	4.64e-01	0.1540	-0.153000	-0.017400	1.62e-01	8.73e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	28	3.78e-01	4.71e-01	0.1530	-0.012800	0.152000	9.07e-01	1.63e-01
CRMPs in Sema3A signaling	16	5.81e-01	6.56e-01	0.1530	0.127000	-0.085500	3.81e-01	5.54e-01
Cell death signalling via NRAGE, NRIF and NADE	74	7.25e-02	1.30e-01	0.1530	-0.046900	-0.145000	4.85e-01	3.08e-02
Translation of Replicase and Assembly of the Replication Transcription Complex	13	6.40e-01	7.04e-01	0.1520	0.037200	-0.148000	8.16e-01	3.56e-01
Defects in cobalamin (B12) metabolism	12	6.64e-01	7.25e-01	0.1520	0.047800	-0.144000	7.74e-01	3.87e-01
RAC3 GTPase cycle	88	4.89e-02	9.50e-02	0.1510	-0.012700	-0.151000	8.36e-01	1.47e-02
Transport of bile salts and organic acids, metal ions and amine compounds	75	7.81e-02	1.39e-01	0.1510	-0.151000	0.010200	2.40e-02	8.79e-01
Inositol phosphate metabolism	47	2.05e-01	2.95e-01	0.1510	0.026900	-0.149000	7.50e-01	7.82e-02
Cytosolic sensors of pathogen-associated DNA	61	1.29e-01	2.03e-01	0.1500	0.149000	-0.017300	4.37e-02	8.15e-01
Defective B3GALTL causes PpS	36	2.92e-01	3.86e-01	0.1500	-0.149000	-0.022000	1.23e-01	8.20e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.96e-01	7.51e-01	0.1500	0.082500	-0.126000	6.36e-01	4.70e-01
Regulation of TP53 Activity through Methylation	18	5.43e-01	6.27e-01	0.1490	0.052500	0.139000	7.00e-01	3.06e-01
Downstream signaling of activated FGFR3	21	4.94e-01	5.82e-01	0.1480	0.138000	0.054300	2.74e-01	6.67e-01
Dermatan sulfate biosynthesis	11	7.04e-01	7.54e-01	0.1480	0.122000	-0.084500	4.85e-01	6.27e-01
COPII-mediated vesicle transport	68	1.14e-01	1.84e-01	0.1480	0.132000	-0.065900	5.90e-02	3.47e-01
Apoptosis	166	3.94e-03	1.12e-02	0.1480	0.096300	0.112000	3.25e-02	1.30e-02
Defects in vitamin and cofactor metabolism	20	5.12e-01	5.99e-01	0.1480	-0.129000	-0.071500	3.18e-01	5.80e-01
Antiviral mechanism by IFN-stimulated genes	79	7.62e-02	1.36e-01	0.1470	0.016100	0.146000	8.05e-01	2.46e-02
SUMOylation of transcription cofactors	42	2.55e-01	3.51e-01	0.1470	0.147000	0.008590	9.98e-02	9.23e-01
EPH-ephrin mediated repulsion of cells	49	1.99e-01	2.89e-01	0.1470	0.046800	0.139000	5.71e-01	9.18e-02
Signaling by FGFR in disease	56	1.65e-01	2.46e-01	0.1470	0.147000	-0.004210	5.74e-02	9.57e-01
Keratan sulfate/keratin metabolism	31	3.78e-01	4.71e-01	0.1470	0.114000	-0.092100	2.71e-01	3.75e-01
Signaling by Receptor Tyrosine Kinases	490	2.69e-07	2.68e-06	0.1460	0.022400	-0.144000	3.97e-01	4.81e-08
SHC-mediated cascade:FGFR4	16	5.96e-01	6.69e-01	0.1450	0.134000	0.055300	3.52e-01	7.02e-01
Interferon Signaling	183	3.60e-03	1.03e-02	0.1450	0.043200	-0.139000	3.14e-01	1.24e-03
Diseases associated with glycosylation precursor biosynthesis	15	6.16e-01	6.85e-01	0.1450	0.128000	0.068100	3.91e-01	6.48e-01
Activation of GABAB receptors	36	3.14e-01	4.10e-01	0.1450	-0.122000	-0.077800	2.06e-01	4.19e-01
GABA B receptor activation	36	3.14e-01	4.10e-01	0.1450	-0.122000	-0.077800	2.06e-01	4.19e-01
IGF1R signaling cascade	47	2.38e-01	3.32e-01	0.1450	0.132000	-0.059400	1.18e-01	4.81e-01
Notch-HLH transcription pathway	27	4.38e-01	5.28e-01	0.1440	0.043800	-0.137000	6.94e-01	2.17e-01
Synthesis, secretion, and deacylation of Ghrelin	15	6.20e-01	6.89e-01	0.1440	0.092700	0.110000	5.34e-01	4.62e-01
Synthesis of PIPs at the Golgi membrane	18	5.70e-01	6.46e-01	0.1430	-0.041300	-0.137000	7.61e-01	3.14e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	7.41e-01	7.83e-01	0.1430	0.127000	-0.065400	4.86e-01	7.20e-01
XBP1(S) activates chaperone genes	43	2.62e-01	3.58e-01	0.1430	0.137000	0.039700	1.19e-01	6.52e-01
Advanced glycosylation endproduct receptor signaling	13	6.82e-01	7.41e-01	0.1420	0.104000	-0.097000	5.16e-01	5.45e-01
O-glycosylation of TSR domain-containing proteins	37	3.22e-01	4.18e-01	0.1420	-0.140000	-0.026500	1.42e-01	7.80e-01
Transmission across Chemical Synapses	232	1.02e-03	3.57e-03	0.1420	-0.142000	0.009340	2.08e-04	8.07e-01
Maturation of nucleoprotein	11	7.22e-01	7.70e-01	0.1420	0.032600	-0.138000	8.52e-01	4.29e-01
Signaling by ERBB2 in Cancer	25	4.78e-01	5.67e-01	0.1410	0.033000	-0.137000	7.76e-01	2.35e-01
Regulated Necrosis	55	2.04e-01	2.93e-01	0.1410	0.054800	-0.129000	4.82e-01	9.68e-02
p75NTR recruits signalling complexes	13	6.86e-01	7.43e-01	0.1410	0.130000	-0.053700	4.18e-01	7.38e-01
Negative regulators of DDX58/IFIH1 signaling	35	3.67e-01	4.61e-01	0.1400	0.093000	-0.105000	3.41e-01	2.81e-01
G alpha (z) signalling events	42	2.86e-01	3.80e-01	0.1400	-0.035700	-0.135000	6.89e-01	1.29e-01
Crosslinking of collagen fibrils	10	7.42e-01	7.83e-01	0.1400	0.045900	0.132000	8.02e-01	4.70e-01
DCC mediated attractive signaling	14	6.57e-01	7.20e-01	0.1390	-0.105000	-0.092000	4.98e-01	5.51e-01
ER Quality Control Compartment (ERQC)	20	5.67e-01	6.45e-01	0.1390	0.065200	-0.123000	6.14e-01	3.41e-01
Transcriptional regulation by RUNX1	173	6.00e-03	1.59e-02	0.1390	0.111000	0.084000	1.20e-02	5.69e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta	68	1.48e-01	2.26e-01	0.1390	0.108000	-0.087600	1.24e-01	2.12e-01
Signaling by FGFR1 in disease	33	3.99e-01	4.93e-01	0.1380	0.098100	-0.097700	3.30e-01	3.32e-01
Activation of BAD and translocation to mitochondria	15	6.56e-01	7.19e-01	0.1380	-0.031000	0.134000	8.36e-01	3.68e-01
Extracellular matrix organization	286	2.88e-04	1.18e-03	0.1380	-0.132000	-0.038500	1.21e-04	2.64e-01
Cellular responses to stimuli	679	5.22e-09	8.09e-08	0.1380	0.080500	0.112000	3.75e-04	7.90e-07
Nucleotide salvage	21	5.58e-01	6.38e-01	0.1370	-0.045600	0.130000	7.17e-01	3.04e-01
Disorders of Developmental Biology	13	6.99e-01	7.51e-01	0.1370	0.121000	-0.064400	4.49e-01	6.88e-01
Disorders of Nervous System Development	13	6.99e-01	7.51e-01	0.1370	0.121000	-0.064400	4.49e-01	6.88e-01
Loss of function of MECP2 in Rett syndrome	13	6.99e-01	7.51e-01	0.1370	0.121000	-0.064400	4.49e-01	6.88e-01
Pervasive developmental disorders	13	6.99e-01	7.51e-01	0.1370	0.121000	-0.064400	4.49e-01	6.88e-01
Mitophagy	26	4.71e-01	5.60e-01	0.1370	0.065300	0.121000	5.64e-01	2.87e-01
Metabolism of vitamins and cofactors	174	6.73e-03	1.76e-02	0.1370	-0.103000	-0.090000	1.88e-02	4.09e-02
Estrogen-dependent gene expression	90	7.44e-02	1.33e-01	0.1370	0.103000	0.090000	9.03e-02	1.40e-01
Signaling by NTRK2 (TRKB)	25	4.85e-01	5.73e-01	0.1370	0.101000	0.092800	3.83e-01	4.22e-01
Synthesis of pyrophosphates in the cytosol	10	7.52e-01	7.92e-01	0.1370	0.133000	0.033700	4.67e-01	8.54e-01
Platelet Aggregation (Plug Formation)	36	3.63e-01	4.58e-01	0.1370	-0.016800	-0.136000	8.61e-01	1.59e-01
IRS-related events triggered by IGF1R	46	2.88e-01	3.82e-01	0.1360	0.116000	-0.071700	1.74e-01	4.00e-01
Glyoxylate metabolism and glycine degradation	28	4.53e-01	5.43e-01	0.1360	0.037600	0.131000	7.31e-01	2.30e-01
Sphingolipid de novo biosynthesis	39	3.43e-01	4.39e-01	0.1360	0.022500	-0.134000	8.08e-01	1.47e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	7.57e-01	7.97e-01	0.1360	-0.010300	-0.136000	9.55e-01	4.58e-01
NOTCH1 Intracellular Domain Regulates Transcription	46	2.85e-01	3.79e-01	0.1360	0.134000	-0.017600	1.15e-01	8.36e-01
Anchoring of the basal body to the plasma membrane	91	8.91e-02	1.54e-01	0.1350	-0.053300	0.124000	3.80e-01	4.12e-02
Transport of small molecules	666	1.93e-08	2.51e-07	0.1350	-0.129000	-0.040800	1.81e-08	7.38e-02
RAC2 GTPase cycle	85	9.51e-02	1.61e-01	0.1350	-0.050600	-0.125000	4.20e-01	4.67e-02
FRS-mediated FGFR2 signaling	19	5.97e-01	6.69e-01	0.1350	0.135000	-0.007420	3.10e-01	9.55e-01
Senescence-Associated Secretory Phenotype (SASP)	51	2.46e-01	3.42e-01	0.1350	0.131000	0.030900	1.06e-01	7.03e-01
FRS-mediated FGFR1 signaling	18	6.15e-01	6.85e-01	0.1340	0.134000	-0.004730	3.24e-01	9.72e-01
Cellular responses to stress	668	1.79e-08	2.34e-07	0.1340	0.070400	0.114000	2.02e-03	5.26e-07
ER-Phagosome pathway	87	9.15e-02	1.56e-01	0.1340	0.112000	0.072900	7.05e-02	2.40e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37	3.70e-01	4.64e-01	0.1340	0.003700	0.134000	9.69e-01	1.59e-01
Diseases associated with N-glycosylation of proteins	20	5.92e-01	6.65e-01	0.1340	0.123000	-0.052900	3.42e-01	6.82e-01
Transcriptional regulation of granulopoiesis	30	4.59e-01	5.49e-01	0.1330	0.109000	-0.076800	3.01e-01	4.67e-01
G beta:gamma signalling through PLC beta	15	6.75e-01	7.34e-01	0.1330	0.044500	-0.126000	7.65e-01	3.99e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	3.77e-01	4.71e-01	0.1320	0.125000	-0.043800	1.84e-01	6.40e-01
Autophagy	126	4.16e-02	8.19e-02	0.1320	0.066300	-0.114000	1.99e-01	2.72e-02
IRS-mediated signalling	42	3.47e-01	4.43e-01	0.1320	0.090700	-0.095500	3.09e-01	2.84e-01
Regulation of TP53 Activity through Association with Co-factors	14	6.98e-01	7.51e-01	0.1310	-0.023600	0.129000	8.78e-01	4.02e-01
Retrograde transport at the Trans-Golgi-Network	48	3.01e-01	3.96e-01	0.1310	0.113000	-0.065500	1.74e-01	4.33e-01
Glycogen metabolism	27	5.00e-01	5.89e-01	0.1300	0.129000	0.018900	2.47e-01	8.65e-01
Gap junction degradation	10	7.71e-01	8.08e-01	0.1300	-0.110000	-0.069200	5.47e-01	7.05e-01
Inwardly rectifying K+ channels	29	4.75e-01	5.63e-01	0.1300	-0.125000	-0.035500	2.44e-01	7.41e-01
GABA synthesis, release, reuptake and degradation	19	6.28e-01	6.96e-01	0.1300	-0.095600	0.087700	4.71e-01	5.08e-01
Insulin receptor signalling cascade	47	3.25e-01	4.21e-01	0.1280	0.088600	-0.092800	2.94e-01	2.71e-01
Sulfur amino acid metabolism	26	5.23e-01	6.09e-01	0.1280	-0.039700	-0.121000	7.26e-01	2.84e-01
ER to Golgi Anterograde Transport	134	4.19e-02	8.24e-02	0.1270	0.124000	-0.026300	1.32e-02	5.99e-01
NOD1/2 Signaling Pathway	32	4.54e-01	5.45e-01	0.1260	-0.071900	-0.104000	4.82e-01	3.08e-01
Developmental Biology	935	6.10e-10	1.21e-08	0.1260	0.011200	0.126000	5.64e-01	9.90e-11
Cell-cell junction organization	52	2.90e-01	3.84e-01	0.1260	-0.126000	0.000859	1.16e-01	9.91e-01
Suppression of phagosomal maturation	13	7.39e-01	7.82e-01	0.1260	-0.109000	0.062800	4.95e-01	6.95e-01
Prolactin receptor signaling	14	7.12e-01	7.63e-01	0.1260	-0.111000	-0.059600	4.74e-01	6.99e-01
Cell-Cell communication	111	6.88e-02	1.25e-01	0.1260	-0.059900	-0.110000	2.76e-01	4.47e-02
Glucagon-type ligand receptors	24	5.65e-01	6.43e-01	0.1260	-0.012000	-0.125000	9.19e-01	2.89e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	36	4.19e-01	5.10e-01	0.1250	-0.108000	-0.063600	2.62e-01	5.09e-01
G alpha (i) signalling events	253	2.41e-03	7.45e-03	0.1250	-0.086600	-0.090300	1.79e-02	1.36e-02
IRE1alpha activates chaperones	45	3.43e-01	4.39e-01	0.1250	0.116000	0.045100	1.77e-01	6.01e-01
Acetylcholine Neurotransmitter Release Cycle	16	6.86e-01	7.43e-01	0.1250	0.023300	0.123000	8.72e-01	3.96e-01
Signaling by NOTCH1	71	2.00e-01	2.89e-01	0.1250	0.112000	-0.055600	1.04e-01	4.18e-01
Cell junction organization	77	1.61e-01	2.43e-01	0.1240	-0.081000	-0.094000	2.19e-01	1.54e-01
RET signaling	38	4.16e-01	5.07e-01	0.1240	-0.004200	-0.124000	9.64e-01	1.86e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	5.84e-01	6.59e-01	0.1240	0.109000	-0.059700	3.57e-01	6.13e-01
Amine ligand-binding receptors	30	4.98e-01	5.86e-01	0.1240	0.023600	0.122000	8.23e-01	2.49e-01
Circadian Clock	66	2.31e-01	3.25e-01	0.1230	0.055600	-0.110000	4.35e-01	1.22e-01
Chondroitin sulfate/dermatan sulfate metabolism	49	3.17e-01	4.12e-01	0.1230	-0.074300	-0.098400	3.68e-01	2.33e-01
Cellular response to chemical stress	182	1.52e-02	3.52e-02	0.1230	0.049100	0.113000	2.54e-01	8.73e-03
PI-3K cascade:FGFR3	14	7.34e-01	7.78e-01	0.1230	0.078800	-0.094500	6.10e-01	5.40e-01
TRAF6 mediated IRF7 activation	18	6.73e-01	7.33e-01	0.1230	0.106000	-0.061300	4.35e-01	6.52e-01
ESR-mediated signaling	154	3.02e-02	6.23e-02	0.1230	0.117000	0.036300	1.22e-02	4.37e-01
Deubiquitination	234	5.24e-03	1.41e-02	0.1230	0.121000	0.019600	1.46e-03	6.07e-01
Adaptive Immune System	703	1.87e-07	1.93e-06	0.1220	-0.070200	-0.099900	1.61e-03	7.17e-06
Glycogen storage diseases	14	7.37e-01	7.80e-01	0.1220	0.117000	-0.033200	4.49e-01	8.30e-01
Keratan sulfate biosynthesis	26	5.65e-01	6.43e-01	0.1200	0.114000	0.037400	3.14e-01	7.42e-01
Apoptotic cleavage of cellular proteins	37	4.61e-01	5.49e-01	0.1200	0.064100	-0.101000	5.00e-01	2.86e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	48	3.66e-01	4.61e-01	0.1190	0.112000	-0.042500	1.81e-01	6.11e-01
Metabolism of water-soluble vitamins and cofactors	114	8.23e-02	1.45e-01	0.1190	-0.093300	-0.074600	8.55e-02	1.69e-01
p75 NTR receptor-mediated signalling	95	1.33e-01	2.09e-01	0.1190	0.000236	-0.119000	9.97e-01	4.48e-02
FRS-mediated FGFR4 signaling	18	6.85e-01	7.43e-01	0.1180	0.118000	-0.004760	3.85e-01	9.72e-01
Glutamate Neurotransmitter Release Cycle	23	6.12e-01	6.83e-01	0.1180	-0.115000	-0.027900	3.39e-01	8.17e-01
Signaling by the B Cell Receptor (BCR)	107	1.14e-01	1.84e-01	0.1180	-0.064600	0.099200	2.49e-01	7.66e-02
mTORC1-mediated signalling	24	6.00e-01	6.72e-01	0.1180	0.115000	0.029200	3.31e-01	8.04e-01
Syndecan interactions	20	6.62e-01	7.24e-01	0.1180	-0.114000	0.031700	3.78e-01	8.06e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	7.01e-01	7.52e-01	0.1180	-0.118000	0.004530	3.99e-01	9.74e-01
CD28 co-stimulation	33	4.93e-01	5.81e-01	0.1180	-0.091300	-0.074700	3.64e-01	4.58e-01
Activation of RAC1	12	7.84e-01	8.19e-01	0.1180	-0.046400	0.108000	7.81e-01	5.17e-01
Phase I - Functionalization of compounds	100	1.24e-01	1.98e-01	0.1170	-0.039800	-0.110000	4.92e-01	5.71e-02
Interleukin-1 signaling	99	1.26e-01	2.00e-01	0.1170	0.061300	0.099600	2.92e-01	8.72e-02
Pre-NOTCH Processing in Golgi	18	6.88e-01	7.44e-01	0.1160	-0.067900	-0.094200	6.18e-01	4.89e-01
FRS-mediated FGFR3 signaling	16	7.30e-01	7.76e-01	0.1160	-0.046400	0.106000	7.48e-01	4.62e-01
Signaling by EGFR in Cancer	25	6.12e-01	6.83e-01	0.1160	0.106000	-0.046300	3.59e-01	6.89e-01
RHOG GTPase cycle	70	2.40e-01	3.34e-01	0.1150	-0.093400	-0.067400	1.77e-01	3.30e-01
Synthesis of substrates in N-glycan biosythesis	58	3.17e-01	4.12e-01	0.1150	-0.009300	-0.114000	9.03e-01	1.32e-01
Signaling by ERBB2 KD Mutants	24	6.26e-01	6.94e-01	0.1140	0.013000	-0.114000	9.12e-01	3.35e-01
Signaling by FGFR3 in disease	18	6.96e-01	7.51e-01	0.1140	0.094600	0.064300	4.87e-01	6.37e-01
Plasma lipoprotein remodeling	29	5.72e-01	6.47e-01	0.1140	-0.113000	0.017400	2.94e-01	8.71e-01
Retrograde neurotrophin signalling	14	7.69e-01	8.07e-01	0.1140	0.076500	-0.084000	6.20e-01	5.86e-01
Transcriptional Regulation by MECP2	59	3.15e-01	4.11e-01	0.1130	0.091200	0.066200	2.26e-01	3.79e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	30	5.63e-01	6.41e-01	0.1130	-0.112000	-0.010800	2.87e-01	9.18e-01
Trafficking of AMPA receptors	30	5.63e-01	6.41e-01	0.1130	-0.112000	-0.010800	2.87e-01	9.18e-01
Norepinephrine Neurotransmitter Release Cycle	16	7.32e-01	7.77e-01	0.1120	-0.082200	-0.076600	5.69e-01	5.96e-01
Signaling by Nuclear Receptors	226	1.42e-02	3.32e-02	0.1120	0.111000	0.013700	3.94e-03	7.23e-01
Interleukin-12 signaling	45	4.31e-01	5.21e-01	0.1120	-0.004830	0.112000	9.55e-01	1.94e-01
Hedgehog ‘off’ state	96	1.59e-01	2.39e-01	0.1120	0.069100	0.087800	2.42e-01	1.37e-01
Erythropoietin activates RAS	13	7.80e-01	8.16e-01	0.1110	-0.069300	-0.087000	6.65e-01	5.87e-01
HS-GAG biosynthesis	31	5.73e-01	6.48e-01	0.1110	-0.102000	0.043000	3.25e-01	6.79e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	24	6.38e-01	7.03e-01	0.1110	0.099500	0.048000	3.99e-01	6.84e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	35	5.23e-01	6.09e-01	0.1100	-0.024100	-0.108000	8.05e-01	2.70e-01
Interleukin-4 and Interleukin-13 signaling	101	1.58e-01	2.39e-01	0.1100	-0.006130	-0.110000	9.15e-01	5.57e-02
Branched-chain amino acid catabolism	21	6.86e-01	7.43e-01	0.1100	0.038000	-0.104000	7.63e-01	4.11e-01
Signaling by ERBB2 TMD/JMD mutants	21	6.78e-01	7.37e-01	0.1090	-0.079000	-0.075800	5.31e-01	5.48e-01
Signaling by Interleukins	409	7.89e-04	2.82e-03	0.1090	-0.005060	-0.109000	8.61e-01	1.64e-04
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	6.47e-01	7.11e-01	0.1080	0.015700	-0.107000	8.92e-01	3.54e-01
Signaling by ERBB4	56	3.69e-01	4.64e-01	0.1070	-0.069400	-0.082000	3.69e-01	2.89e-01
Protein folding	90	2.03e-01	2.93e-01	0.1070	0.082500	0.068700	1.77e-01	2.61e-01
Signaling by NOTCH2	31	5.96e-01	6.69e-01	0.1070	0.092000	-0.054700	3.75e-01	5.98e-01
Cargo trafficking to the periciliary membrane	49	4.36e-01	5.26e-01	0.1060	-0.104000	-0.021100	2.10e-01	7.98e-01
Chaperonin-mediated protein folding	84	2.36e-01	3.31e-01	0.1060	0.084200	0.063900	1.82e-01	3.12e-01
Signaling by NOTCH3	47	4.60e-01	5.49e-01	0.1060	0.103000	-0.024400	2.23e-01	7.72e-01
G alpha (s) signalling events	116	1.41e-01	2.18e-01	0.1060	-0.027200	-0.102000	6.13e-01	5.79e-02
Macroautophagy	111	1.70e-01	2.53e-01	0.1050	0.062600	-0.084300	2.55e-01	1.25e-01
RUNX2 regulates osteoblast differentiation	22	6.90e-01	7.45e-01	0.1050	0.088300	0.056200	4.73e-01	6.48e-01
Phase II - Conjugation of compounds	93	2.18e-01	3.10e-01	0.1040	-0.102000	-0.021400	8.96e-02	7.22e-01
Alpha-protein kinase 1 signaling pathway	11	8.33e-01	8.57e-01	0.1040	-0.078100	-0.068400	6.54e-01	6.94e-01
Diseases of glycosylation	138	1.05e-01	1.75e-01	0.1030	-0.084600	-0.059200	8.66e-02	2.30e-01
C-type lectin receptors (CLRs)	135	1.22e-01	1.96e-01	0.1020	-0.102000	0.008470	4.06e-02	8.65e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	8.58e-01	8.79e-01	0.1020	0.064400	-0.079700	7.25e-01	6.62e-01
Detoxification of Reactive Oxygen Species	33	5.90e-01	6.64e-01	0.1020	-0.094100	-0.040000	3.50e-01	6.91e-01
Extra-nuclear estrogen signaling	68	3.56e-01	4.51e-01	0.1020	0.088800	-0.050300	2.05e-01	4.74e-01
Signaling by NOTCH	173	6.49e-02	1.19e-01	0.1020	0.049500	0.089000	2.62e-01	4.36e-02
E3 ubiquitin ligases ubiquitinate target proteins	44	5.03e-01	5.91e-01	0.1020	0.015400	0.100000	8.60e-01	2.49e-01
CD209 (DC-SIGN) signaling	20	7.29e-01	7.75e-01	0.1010	-0.044400	-0.091200	7.31e-01	4.80e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	8.00e-01	8.30e-01	0.1010	0.096800	-0.027000	5.16e-01	8.56e-01
Interleukin-2 signaling	11	8.49e-01	8.72e-01	0.1000	0.024800	-0.097400	8.87e-01	5.76e-01
Signalling to ERKs	33	6.15e-01	6.85e-01	0.1000	0.050700	-0.086700	6.14e-01	3.89e-01
Anti-inflammatory response favouring Leishmania parasite infection	129	1.39e-01	2.15e-01	0.1000	-0.046500	-0.088700	3.62e-01	8.23e-02
Leishmania parasite growth and survival	129	1.39e-01	2.15e-01	0.1000	-0.046500	-0.088700	3.62e-01	8.23e-02
Diseases associated with glycosaminoglycan metabolism	40	5.49e-01	6.31e-01	0.1000	-0.000153	-0.100000	9.99e-01	2.74e-01
NR1H2 and NR1H3-mediated signaling	44	5.08e-01	5.95e-01	0.0999	-0.061000	-0.079200	4.84e-01	3.64e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	53	4.48e-01	5.38e-01	0.0992	0.078700	0.060500	3.22e-01	4.46e-01
p38MAPK events	13	8.30e-01	8.55e-01	0.0991	-0.073100	0.066900	6.48e-01	6.76e-01
RUNX2 regulates bone development	29	6.59e-01	7.21e-01	0.0982	0.097800	-0.009600	3.62e-01	9.29e-01
GPCR downstream signalling	516	5.96e-04	2.22e-03	0.0981	-0.059800	-0.077700	2.05e-02	2.63e-03
SARS-CoV-2-host interactions	177	7.54e-02	1.35e-01	0.0980	0.041400	0.088900	3.43e-01	4.16e-02
ALK mutants bind TKIs	12	8.42e-01	8.66e-01	0.0979	-0.097500	0.009840	5.59e-01	9.53e-01
Processing of SMDT1	14	8.15e-01	8.42e-01	0.0977	0.038300	0.089800	8.04e-01	5.61e-01
PINK1-PRKN Mediated Mitophagy	19	7.62e-01	8.01e-01	0.0965	0.086200	0.043400	5.15e-01	7.43e-01
Signalling to RAS	20	7.60e-01	8.00e-01	0.0964	-0.092100	0.028400	4.76e-01	8.26e-01
Diseases of metabolism	237	3.53e-02	7.11e-02	0.0962	-0.072300	-0.063500	5.57e-02	9.29e-02
Beta-catenin independent WNT signaling	138	1.42e-01	2.18e-01	0.0960	0.071400	0.064200	1.48e-01	1.93e-01
Peptide ligand-binding receptors	147	1.27e-01	2.01e-01	0.0959	0.081400	0.050800	8.90e-02	2.89e-01
Cytokine Signaling in Immune system	640	1.95e-04	8.42e-04	0.0959	-0.010800	-0.095200	6.42e-01	4.29e-05
TAK1-dependent IKK and NF-kappa-B activation	28	6.83e-01	7.42e-01	0.0958	0.020500	-0.093600	8.51e-01	3.91e-01
Interleukin-20 family signaling	20	7.65e-01	8.04e-01	0.0956	0.042700	-0.085500	7.41e-01	5.08e-01
PPARA activates gene expression	113	2.21e-01	3.14e-01	0.0954	0.026400	-0.091700	6.28e-01	9.24e-02
RHOF GTPase cycle	42	5.69e-01	6.46e-01	0.0949	0.094300	-0.010700	2.90e-01	9.04e-01
Cellular Senescence	126	1.78e-01	2.62e-01	0.0945	0.072100	0.061100	1.62e-01	2.37e-01
TRP channels	23	7.37e-01	7.80e-01	0.0944	-0.093700	0.010700	4.37e-01	9.29e-01
MTOR signalling	41	5.86e-01	6.60e-01	0.0943	0.035100	-0.087600	6.98e-01	3.32e-01
RHO GTPase Effectors	231	4.57e-02	8.91e-02	0.0939	0.039100	0.085400	3.06e-01	2.56e-02
Ephrin signaling	19	7.77e-01	8.14e-01	0.0937	0.009420	0.093300	9.43e-01	4.82e-01
Signaling by FLT3 fusion proteins	19	7.84e-01	8.19e-01	0.0936	0.081400	-0.046200	5.39e-01	7.27e-01
Antigen processing: Ubiquitination & Proteasome degradation	286	2.29e-02	4.94e-02	0.0935	0.038900	0.085100	2.59e-01	1.35e-02
MHC class II antigen presentation	103	2.58e-01	3.54e-01	0.0933	-0.018200	-0.091500	7.50e-01	1.09e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	6.38e-01	7.03e-01	0.0926	0.072300	0.057900	4.66e-01	5.59e-01
Mitochondrial calcium ion transport	21	7.73e-01	8.11e-01	0.0916	-0.051800	0.075600	6.81e-01	5.49e-01
Interleukin-12 family signaling	53	5.17e-01	6.04e-01	0.0912	0.001150	0.091200	9.88e-01	2.51e-01
Regulation of lipid metabolism by PPARalpha	115	2.50e-01	3.45e-01	0.0909	0.031500	-0.085200	5.59e-01	1.15e-01
VEGFR2 mediated vascular permeability	27	7.17e-01	7.67e-01	0.0898	-0.031100	-0.084300	7.80e-01	4.49e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	19	7.98e-01	8.29e-01	0.0894	-0.088200	0.014700	5.06e-01	9.12e-01
Infection with Mycobacterium tuberculosis	27	7.24e-01	7.71e-01	0.0887	-0.085800	-0.022400	4.40e-01	8.41e-01
Metabolism of cofactors	19	7.94e-01	8.27e-01	0.0886	0.062700	0.062600	6.36e-01	6.37e-01
GABA receptor activation	50	5.71e-01	6.47e-01	0.0879	-0.057100	0.066800	4.85e-01	4.14e-01
Programmed Cell Death	195	1.01e-01	1.69e-01	0.0878	0.071500	0.051000	8.57e-02	2.20e-01
IRAK2 mediated activation of TAK1 complex	10	8.90e-01	9.06e-01	0.0872	-0.082800	-0.027500	6.50e-01	8.80e-01
Downstream TCR signaling	92	3.51e-01	4.46e-01	0.0863	0.033900	0.079400	5.75e-01	1.88e-01
Metabolism of proteins	1732	2.25e-08	2.85e-07	0.0861	0.033100	0.079400	2.39e-02	6.08e-08
RORA activates gene expression	18	8.25e-01	8.51e-01	0.0858	-0.068000	0.052300	6.18e-01	7.01e-01
HDMs demethylate histones	21	7.96e-01	8.28e-01	0.0856	-0.010900	0.084900	9.31e-01	5.01e-01
Biological oxidations	200	1.11e-01	1.82e-01	0.0849	-0.061100	-0.058900	1.37e-01	1.52e-01
MAPK1/MAPK3 signaling	267	6.33e-02	1.16e-01	0.0848	0.044600	-0.072100	2.10e-01	4.29e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	4.66e-01	5.55e-01	0.0847	0.041400	-0.073900	5.41e-01	2.75e-01
EPH-Ephrin signaling	92	3.77e-01	4.71e-01	0.0846	0.084000	-0.009920	1.64e-01	8.69e-01
Vesicle-mediated transport	632	1.63e-03	5.36e-03	0.0840	0.004330	-0.083900	8.53e-01	3.42e-04
Activation of G protein gated Potassium channels	23	7.86e-01	8.19e-01	0.0838	-0.083200	0.009860	4.90e-01	9.35e-01
G protein gated Potassium channels	23	7.86e-01	8.19e-01	0.0838	-0.083200	0.009860	4.90e-01	9.35e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	23	7.86e-01	8.19e-01	0.0838	-0.083200	0.009860	4.90e-01	9.35e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	5.83e-01	6.59e-01	0.0838	-0.009360	-0.083200	9.08e-01	3.04e-01
Membrane Trafficking	595	3.28e-03	9.55e-03	0.0821	0.020900	-0.079400	3.86e-01	9.88e-04
Signaling by Hedgehog	132	2.68e-01	3.64e-01	0.0819	0.081900	-0.002970	1.05e-01	9.53e-01
EPHB-mediated forward signaling	34	7.18e-01	7.68e-01	0.0814	0.025200	-0.077400	8.00e-01	4.35e-01
CD28 dependent PI3K/Akt signaling	22	8.04e-01	8.33e-01	0.0814	0.002170	-0.081400	9.86e-01	5.09e-01
MAPK family signaling cascades	305	5.60e-02	1.05e-01	0.0813	0.054000	-0.060800	1.06e-01	6.86e-02
Cargo concentration in the ER	33	7.30e-01	7.76e-01	0.0809	0.065900	-0.046900	5.13e-01	6.41e-01
Peptide hormone metabolism	70	5.15e-01	6.02e-01	0.0800	0.012300	-0.079100	8.59e-01	2.53e-01
RAF/MAP kinase cascade	261	9.48e-02	1.60e-01	0.0792	0.038400	-0.069200	2.86e-01	5.47e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	7.97e-01	8.28e-01	0.0790	-0.063800	0.046500	5.81e-01	6.87e-01
Depolymerisation of the Nuclear Lamina	15	8.71e-01	8.91e-01	0.0789	-0.024200	0.075100	8.71e-01	6.14e-01
Glycosaminoglycan metabolism	118	3.47e-01	4.42e-01	0.0788	0.049600	-0.061200	3.52e-01	2.51e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	33	7.29e-01	7.75e-01	0.0788	0.060100	0.050900	5.50e-01	6.13e-01
CLEC7A (Dectin-1) signaling	97	4.08e-01	5.00e-01	0.0787	-0.000355	0.078700	9.95e-01	1.81e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	1.88e-01	2.75e-01	0.0784	0.015500	0.076800	7.19e-01	7.51e-02
Tight junction interactions	24	8.07e-01	8.36e-01	0.0781	0.035800	-0.069400	7.61e-01	5.56e-01
Glutathione conjugation	35	7.23e-01	7.70e-01	0.0780	-0.023500	-0.074400	8.10e-01	4.46e-01
Pyruvate metabolism	29	7.67e-01	8.06e-01	0.0775	0.021000	0.074600	8.45e-01	4.87e-01
Response of Mtb to phagocytosis	23	8.27e-01	8.53e-01	0.0753	-0.062600	0.042000	6.04e-01	7.28e-01
Presynaptic function of Kainate receptors	16	8.72e-01	8.91e-01	0.0753	-0.005410	-0.075100	9.70e-01	6.03e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	6.36e-01	7.02e-01	0.0752	0.044300	-0.060800	5.70e-01	4.36e-01
PIP3 activates AKT signaling	258	1.22e-01	1.96e-01	0.0750	0.069500	-0.028100	5.49e-02	4.37e-01
Regulation of localization of FOXO transcription factors	11	9.13e-01	9.26e-01	0.0732	0.037500	0.062900	8.29e-01	7.18e-01
Trafficking of GluR2-containing AMPA receptors	17	8.76e-01	8.94e-01	0.0732	-0.045700	0.057200	7.44e-01	6.83e-01
Signal Transduction	2286	2.14e-07	2.16e-06	0.0729	0.031100	-0.066000	1.69e-02	3.98e-07
Signaling by PDGFR in disease	20	8.53e-01	8.76e-01	0.0725	0.071600	0.011600	5.79e-01	9.29e-01
Signaling by GPCR	573	1.38e-02	3.24e-02	0.0711	-0.026500	-0.066000	2.80e-01	7.19e-03
Josephin domain DUBs	11	9.22e-01	9.33e-01	0.0711	0.044200	-0.055600	7.99e-01	7.49e-01
Activation of gene expression by SREBF (SREBP)	42	7.33e-01	7.77e-01	0.0707	0.011600	-0.069700	8.97e-01	4.34e-01
Tie2 Signaling	18	8.72e-01	8.91e-01	0.0703	-0.049000	-0.050400	7.19e-01	7.11e-01
Oxidative Stress Induced Senescence	64	6.15e-01	6.85e-01	0.0702	0.053400	0.045600	4.60e-01	5.28e-01
Selective autophagy	58	6.48e-01	7.11e-01	0.0700	0.064600	0.026900	3.95e-01	7.23e-01
RAB geranylgeranylation	62	6.39e-01	7.04e-01	0.0688	-0.023400	-0.064700	7.50e-01	3.78e-01
Signaling by Rho GTPases	600	1.89e-02	4.20e-02	0.0682	0.019900	-0.065200	4.08e-01	6.61e-03
Signaling by PDGF	52	7.01e-01	7.52e-01	0.0678	0.004710	-0.067600	9.53e-01	3.99e-01
Protein localization	151	3.56e-01	4.51e-01	0.0673	0.064500	0.019100	1.72e-01	6.85e-01
Regulation of MECP2 expression and activity	31	8.08e-01	8.36e-01	0.0671	0.062500	0.024600	5.47e-01	8.12e-01
Intra-Golgi traffic	43	7.50e-01	7.91e-01	0.0665	-0.012900	-0.065300	8.84e-01	4.59e-01
Intracellular signaling by second messengers	296	1.51e-01	2.30e-01	0.0665	0.026800	-0.060900	4.29e-01	7.21e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	616	2.15e-02	4.67e-02	0.0662	0.018400	-0.063600	4.39e-01	7.28e-03
Transcriptional activation of mitochondrial biogenesis	51	7.21e-01	7.70e-01	0.0657	0.065300	-0.006990	4.20e-01	9.31e-01
RHOH GTPase cycle	35	8.03e-01	8.33e-01	0.0654	0.023400	-0.061000	8.10e-01	5.32e-01
Infectious disease	856	5.47e-03	1.46e-02	0.0648	0.020500	0.061500	3.13e-01	2.42e-03
Metabolism of steroids	145	3.97e-01	4.91e-01	0.0646	-0.055700	-0.032700	2.47e-01	4.98e-01
RND1 GTPase cycle	41	7.75e-01	8.12e-01	0.0645	-0.064300	0.004990	4.76e-01	9.56e-01
G alpha (q) signalling events	184	3.11e-01	4.07e-01	0.0645	-0.054600	-0.034400	2.02e-01	4.22e-01
TCR signaling	114	5.07e-01	5.94e-01	0.0634	-0.063200	0.005290	2.44e-01	9.22e-01
Synthesis of very long-chain fatty acyl-CoAs	18	8.96e-01	9.11e-01	0.0631	-0.057900	-0.025100	6.71e-01	8.54e-01
Pre-NOTCH Transcription and Translation	34	8.14e-01	8.42e-01	0.0626	-0.038600	-0.049200	6.97e-01	6.19e-01
RHOD GTPase cycle	51	7.43e-01	7.85e-01	0.0620	-0.009830	-0.061200	9.03e-01	4.49e-01
Metabolism of carbohydrates	273	2.17e-01	3.09e-01	0.0619	-0.011100	0.060900	7.52e-01	8.39e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	9.32e-01	9.42e-01	0.0618	0.027500	0.055400	8.69e-01	7.40e-01
Fatty acyl-CoA biosynthesis	29	8.45e-01	8.68e-01	0.0616	-0.028000	-0.054900	7.94e-01	6.09e-01
Pyroptosis	26	8.64e-01	8.84e-01	0.0605	-0.049300	-0.035000	6.63e-01	7.57e-01
Antigen processing-Cross presentation	103	5.85e-01	6.59e-01	0.0594	0.058600	-0.009810	3.05e-01	8.64e-01
TP53 Regulates Metabolic Genes	83	6.42e-01	7.06e-01	0.0591	0.022100	0.054800	7.28e-01	3.88e-01
Calnexin/calreticulin cycle	25	8.89e-01	9.06e-01	0.0562	0.055200	-0.011000	6.33e-01	9.24e-01
Cilium Assembly	173	4.51e-01	5.42e-01	0.0557	-0.055700	0.002660	2.07e-01	9.52e-01
Apoptotic execution phase	45	8.10e-01	8.38e-01	0.0555	0.053300	0.015400	5.36e-01	8.58e-01
Mitochondrial biogenesis	71	7.18e-01	7.68e-01	0.0551	0.028900	0.047000	6.74e-01	4.94e-01
Insulin processing	23	9.01e-01	9.15e-01	0.0550	-0.055000	-0.001880	6.48e-01	9.88e-01
RND2 GTPase cycle	42	8.29e-01	8.54e-01	0.0542	0.016600	0.051600	8.53e-01	5.63e-01
SARS-CoV Infections	337	2.27e-01	3.21e-01	0.0539	0.043500	0.031900	1.72e-01	3.15e-01
RAS processing	20	9.17e-01	9.30e-01	0.0535	0.003130	0.053400	9.81e-01	6.79e-01
ECM proteoglycans	56	7.86e-01	8.19e-01	0.0531	-0.049600	-0.018900	5.21e-01	8.07e-01
Asparagine N-linked glycosylation	277	3.57e-01	4.51e-01	0.0504	0.049800	-0.007940	1.55e-01	8.20e-01
GPCR ligand binding	345	2.75e-01	3.70e-01	0.0497	0.035100	0.035200	2.64e-01	2.62e-01
Fc epsilon receptor (FCERI) signaling	128	6.58e-01	7.20e-01	0.0470	-0.046600	0.006160	3.63e-01	9.04e-01
BBSome-mediated cargo-targeting to cilium	23	9.29e-01	9.40e-01	0.0457	0.016300	0.042700	8.92e-01	7.23e-01
Signaling by NTRK3 (TRKC)	17	9.47e-01	9.54e-01	0.0457	0.027000	0.036800	8.47e-01	7.93e-01
Heme biosynthesis	14	9.59e-01	9.66e-01	0.0454	0.027500	-0.036100	8.59e-01	8.15e-01
Pre-NOTCH Expression and Processing	50	8.56e-01	8.77e-01	0.0450	-0.033400	-0.030100	6.83e-01	7.13e-01
RND3 GTPase cycle	42	8.86e-01	9.04e-01	0.0435	0.012800	0.041500	8.86e-01	6.42e-01
Factors involved in megakaryocyte development and platelet production	119	7.20e-01	7.69e-01	0.0424	-0.034900	-0.024100	5.11e-01	6.50e-01
Transport to the Golgi and subsequent modification	163	6.73e-01	7.33e-01	0.0409	0.035400	-0.020600	4.36e-01	6.50e-01
Myogenesis	27	9.39e-01	9.47e-01	0.0401	-0.024900	0.031500	8.23e-01	7.77e-01
Axon guidance	511	3.17e-01	4.12e-01	0.0397	-0.013300	0.037400	6.08e-01	1.50e-01
Transcriptional Regulation by VENTX	38	9.19e-01	9.30e-01	0.0392	-0.022400	0.032200	8.11e-01	7.32e-01
Post-translational protein modification	1279	6.47e-02	1.19e-01	0.0389	0.016500	0.035200	3.26e-01	3.63e-02
Organelle biogenesis and maintenance	244	6.52e-01	7.15e-01	0.0349	-0.031100	0.015700	4.03e-01	6.73e-01
Metalloprotease DUBs	20	9.65e-01	9.72e-01	0.0345	-0.003640	0.034300	9.77e-01	7.91e-01
Heparan sulfate/heparin (HS-GAG) metabolism	54	9.07e-01	9.22e-01	0.0344	-0.033100	-0.009450	6.74e-01	9.04e-01
Signal transduction by L1	21	9.66e-01	9.72e-01	0.0335	0.010200	-0.031900	9.36e-01	8.00e-01
Cytoprotection by HMOX1	59	9.08e-01	9.22e-01	0.0329	0.032800	0.003330	6.63e-01	9.65e-01
Post-translational protein phosphorylation	101	8.55e-01	8.77e-01	0.0326	0.014100	-0.029400	8.07e-01	6.10e-01
SARS-CoV-2 Infection	262	6.65e-01	7.25e-01	0.0324	0.001450	0.032400	9.68e-01	3.68e-01
Class I MHC mediated antigen processing & presentation	358	5.90e-01	6.64e-01	0.0313	0.027800	0.014300	3.67e-01	6.42e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	102	8.59e-01	8.79e-01	0.0312	0.028100	0.013700	6.24e-01	8.11e-01
Class A/1 (Rhodopsin-like receptors)	247	7.00e-01	7.52e-01	0.0308	0.024000	0.019300	5.17e-01	6.01e-01
Nervous system development	534	4.90e-01	5.78e-01	0.0307	-0.014000	0.027400	5.83e-01	2.82e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	9.87e-01	9.90e-01	0.0279	-0.011800	0.025300	9.46e-01	8.84e-01
Vitamin D (calciferol) metabolism	11	9.87e-01	9.90e-01	0.0277	0.025500	0.010900	8.84e-01	9.50e-01
Aggrephagy	23	9.77e-01	9.82e-01	0.0260	0.025900	0.003020	8.30e-01	9.80e-01
Interleukin-1 family signaling	130	8.91e-01	9.06e-01	0.0247	-0.023800	0.006640	6.40e-01	8.96e-01
Metabolism	1917	2.39e-01	3.33e-01	0.0234	-0.018500	-0.014400	1.88e-01	3.06e-01
ADORA2B mediated anti-inflammatory cytokines production	96	9.33e-01	9.42e-01	0.0223	0.008020	-0.020800	8.92e-01	7.25e-01
COPI-independent Golgi-to-ER retrograde traffic	33	9.77e-01	9.82e-01	0.0213	0.007620	0.019900	9.40e-01	8.43e-01
Metal ion SLC transporters	23	9.85e-01	9.89e-01	0.0210	-0.016000	0.013500	8.94e-01	9.10e-01
Disease	1605	4.21e-01	5.11e-01	0.0197	0.011600	0.015900	4.44e-01	2.95e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	116	9.40e-01	9.48e-01	0.0193	0.013700	-0.013600	7.99e-01	8.01e-01
STING mediated induction of host immune responses	13	9.93e-01	9.93e-01	0.0184	0.007110	0.017000	9.65e-01	9.16e-01
Signaling by KIT in disease	20	9.91e-01	9.92e-01	0.0172	0.015800	0.006800	9.03e-01	9.58e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	9.91e-01	9.92e-01	0.0172	0.015800	0.006800	9.03e-01	9.58e-01
Neurotransmitter release cycle	49	9.90e-01	9.92e-01	0.0121	-0.009750	0.007080	9.06e-01	9.32e-01

---

Detailed Gene set reports

Unwinding of DNA

Unwinding of DNA

metric	value
setSize	12
pMANOVA	1.14e-07
p.adjustMANOVA	1.25e-06
s.dist	0.944
s.meth	-0.077
s.rna	0.941
p.meth	0.644
p.rna	1.64e-08

Top 20 genes

Gene	meth	rna
MCM4	-9501.5	8782
CDC45	-9051.5	8968
MCM2	-9229.5	8788
MCM5	-9785.5	6982
GINS3	-7276.5	8564
GINS2	-5643.5	8703
GINS1	-4849.5	8900
MCM6	-3901.5	8700
MCM3	-2759.5	8325
GINS4	-390.5	8952

Click HERE to show all gene set members

All member genes

	meth	rna
CDC45	-9051.5	8968
GINS1	-4849.5	8900
GINS2	-5643.5	8703
GINS3	-7276.5	8564
GINS4	-390.5	8952
MCM2	-9229.5	8788
MCM3	-2759.5	8325
MCM4	-9501.5	8782
MCM5	-9785.5	6982
MCM6	-3901.5	8700
MCM7	1646.5	8014
MCM8	962.5	8634

---

---

Defective pyroptosis

Defective pyroptosis

metric	value
setSize	13
pMANOVA	1.23e-06
p.adjustMANOVA	1.02e-05
s.dist	0.831
s.meth	0.154
s.rna	0.816
p.meth	0.336
p.rna	3.47e-07

Top 20 genes

Gene	meth	rna
POLA2	2611.5	7700
PRIM1	1943.5	7625
DNMT3A	1442.5	5421
EED	924.5	7313

Click HERE to show all gene set members

All member genes

	meth	rna
DNMT1	-6290.5	7696
DNMT3A	1442.5	5421
DNMT3B	-6732.5	8432
EED	924.5	7313
EZH2	-8904.5	8832
H2AFX	-327.5	8468
POLA1	-4762.5	6653
POLA2	2611.5	7700
PRIM1	1943.5	7625
PRIM2	-11838.5	8571
RBBP4	-941.5	5827
RBBP7	-141.5	6906
SUZ12	-7206.5	8116

---

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

metric	value
setSize	11
pMANOVA	3.56e-05
p.adjustMANOVA	0.000191
s.dist	0.785
s.meth	0.086
s.rna	0.78
p.meth	0.622
p.rna	7.39e-06

Top 20 genes

Gene	meth	rna
CSNK2B	953.5	172

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-8748.5	8885
CCNB2	-4543.5	8890
CDK1	-1046.5	8760
CSNK2A1	-1013.5	6674
CSNK2A2	-2075.5	3056
CSNK2B	953.5	172
NCAPD2	-5151.5	8535
NCAPG	-5930.5	8805
NCAPH	-3654.5	8949
SMC2	-3394.5	8181
SMC4	-5551.5	8439

---

---

Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway

metric	value
setSize	11
pMANOVA	8.77e-05
p.adjustMANOVA	0.000417
s.dist	0.763
s.meth	0.621
s.rna	-0.443
p.meth	0.000358
p.rna	0.011

Top 20 genes

Gene	meth	rna
HLA-E	2926.5	-5707
HLA-B	3466.5	-4555
HLA-F	3508.5	-4401
HLA-C	2784.5	-5310
B2M	1701.5	-5302
CTSL	2392.5	-1173
HLA-G	3326.5	-492

Click HERE to show all gene set members

All member genes

	meth	rna
B2M	1701.5	-5302
CTSL	2392.5	-1173
CTSS	-8041.5	-6758
CTSV	2289.5	8736
HLA-A	-1015.5	-2708
HLA-B	3466.5	-4555
HLA-C	2784.5	-5310
HLA-E	2926.5	-5707
HLA-F	3508.5	-4401
HLA-G	3326.5	-492
LNPEP	-5378.5	-2914

---

---

DNA strand elongation

DNA strand elongation

metric	value
setSize	32
pMANOVA	3.96e-12
p.adjustMANOVA	1.08e-10
s.dist	0.738
s.meth	0.0389
s.rna	0.737
p.meth	0.704
p.rna	5.14e-13

Top 20 genes

Gene	meth	rna
POLA2	2611.5	7700
PRIM1	1943.5	7625
MCM7	1646.5	8014
MCM8	962.5	8634
RFC2	890.5	7737
RPA2	1002.5	5584

Click HERE to show all gene set members

All member genes

	meth	rna
CDC45	-9051.5	8968
DNA2	-4346.5	8434
FEN1	-2132.5	8745
GINS1	-4849.5	8900
GINS2	-5643.5	8703
GINS3	-7276.5	8564
GINS4	-390.5	8952
LIG1	-416.5	6552
MCM2	-9229.5	8788
MCM3	-2759.5	8325
MCM4	-9501.5	8782
MCM5	-9785.5	6982
MCM6	-3901.5	8700
MCM7	1646.5	8014
MCM8	962.5	8634
PCNA	-4692.5	8487
POLA1	-4762.5	6653
POLA2	2611.5	7700
POLD1	-7153.5	4282
POLD2	-2453.5	6109
POLD3	-1734.5	339
POLD4	350.5	-4338
PRIM1	1943.5	7625
PRIM2	-11838.5	8571
RFC1	-5544.5	-460
RFC2	890.5	7737
RFC3	-9533.5	7667
RFC4	-7193.5	8880
RFC5	-1010.5	8266
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891

---

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

metric	value
setSize	33
pMANOVA	1.96e-12
p.adjustMANOVA	5.68e-11
s.dist	0.735
s.meth	0.0792
s.rna	0.731
p.meth	0.431
p.rna	3.51e-13

Top 20 genes

Gene	meth	rna
POLE2	2681.5	8867
CDC7	2539.5	8693
POLA2	2611.5	7700
PRIM1	1943.5	7625
MCM7	1646.5	8014
CDK2	1640.5	5887
CDC6	1008.5	8984
MCM8	962.5	8634
POLE3	963.5	5939
RPA2	1002.5	5584
ORC1	428.5	8818

Click HERE to show all gene set members

All member genes

	meth	rna
CDC45	-9051.5	8968
CDC6	1008.5	8984
CDC7	2539.5	8693
CDK2	1640.5	5887
CDT1	-10544.5	8764
DBF4	-2179.5	8709
GMNN	-2092.5	8499
MCM10	-4999.5	8953
MCM2	-9229.5	8788
MCM3	-2759.5	8325
MCM4	-9501.5	8782
MCM5	-9785.5	6982
MCM6	-3901.5	8700
MCM7	1646.5	8014
MCM8	962.5	8634
ORC1	428.5	8818
ORC2	-4921.5	5499
ORC3	-6515.5	3222
ORC4	-648.5	309
ORC5	-4189.5	7212
ORC6	-4026.5	8938
POLA1	-4762.5	6653
POLA2	2611.5	7700
POLE	-11440.5	7578
POLE2	2681.5	8867
POLE3	963.5	5939
POLE4	-5778.5	1630
PRIM1	1943.5	7625
PRIM2	-11838.5	8571
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891
RPA4	-8233.5	-5474

---

---

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

metric	value
setSize	37
pMANOVA	2.69e-13
p.adjustMANOVA	8.99e-12
s.dist	0.719
s.meth	0.0975
s.rna	0.713
p.meth	0.305
p.rna	6.17e-14

Top 20 genes

Gene	meth	rna
CDC7	2539.5	8693
MCM7	1646.5	8014
CDK2	1640.5	5887
CDC6	1008.5	8984
MCM8	962.5	8634
RFC2	890.5	7737
RPA2	1002.5	5584
ATRIP	1339.5	3743
ORC1	428.5	8818

Click HERE to show all gene set members

All member genes

	meth	rna
ATR	-6469.5	7826
ATRIP	1339.5	3743
CDC25A	-5154.5	8956
CDC25C	-7531.5	8932
CDC45	-9051.5	8968
CDC6	1008.5	8984
CDC7	2539.5	8693
CDK2	1640.5	5887
CHEK1	-4739.5	8838
CLSPN	-1399.5	8811
DBF4	-2179.5	8709
HUS1	-3648.5	1638
MCM10	-4999.5	8953
MCM2	-9229.5	8788
MCM3	-2759.5	8325
MCM4	-9501.5	8782
MCM5	-9785.5	6982
MCM6	-3901.5	8700
MCM7	1646.5	8014
MCM8	962.5	8634
ORC1	428.5	8818
ORC2	-4921.5	5499
ORC3	-6515.5	3222
ORC4	-648.5	309
ORC5	-4189.5	7212
ORC6	-4026.5	8938
RAD1	-2144.5	4001
RAD17	-1581.5	-225
RAD9A	-5228.5	2822
RAD9B	-2394.5	-5
RFC2	890.5	7737
RFC3	-9533.5	7667
RFC4	-7193.5	8880
RFC5	-1010.5	8266
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891

---

---

Mucopolysaccharidoses

Mucopolysaccharidoses

metric	value
setSize	11
pMANOVA	0.00021
p.adjustMANOVA	0.000894
s.dist	0.714
s.meth	-0.0698
s.rna	-0.711
p.meth	0.689
p.rna	4.46e-05

Top 20 genes

Gene	meth	rna
IDS	-6503.5	-6850
ARSB	-7762.5	-5538
GUSB	-7081.5	-5336
HGSNAT	-8841.5	-4229
GLB1	-4976.5	-6567
SGSH	-5095.5	-3305
NAGLU	-1600.5	-6630
IDUA	-2471.5	-3814
GALNS	-11882.5	-783
GNS	-425.5	-4464

Click HERE to show all gene set members

All member genes

	meth	rna
ARSB	-7762.5	-5538
GALNS	-11882.5	-783
GLB1	-4976.5	-6567
GNS	-425.5	-4464
GUSB	-7081.5	-5336
HGSNAT	-8841.5	-4229
HYAL1	2484.5	-7132
IDS	-6503.5	-6850
IDUA	-2471.5	-3814
NAGLU	-1600.5	-6630
SGSH	-5095.5	-3305

---

---

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

metric	value
setSize	10
pMANOVA	0.000449
p.adjustMANOVA	0.00174
s.dist	0.706
s.meth	0.447
s.rna	0.547
p.meth	0.0145
p.rna	0.00273

Top 20 genes

Gene	meth	rna
TFAP2A	3307.5	8861
TFAP2D	3634.5	7045
TFAP2B	3807.5	6440
TFAP2C	3002.5	6879
KCTD15	2589.5	5982
TFAP2E	3308.5	2554

Click HERE to show all gene set members

All member genes

	meth	rna
KCTD1	-11566.5	8188
KCTD15	2589.5	5982
SUMO1	-1742.5	2574
TFAP2A	3307.5	8861
TFAP2B	3807.5	6440
TFAP2C	3002.5	6879
TFAP2D	3634.5	7045
TFAP2E	3308.5	2554
UBE2I	-972.5	6338
WWOX	-12417.5	-1759

---

---

Digestion

Digestion

metric	value
setSize	11
pMANOVA	0.000281
p.adjustMANOVA	0.00116
s.dist	0.706
s.meth	-0.702
s.rna	0.0718
p.meth	5.5e-05
p.rna	0.68

Top 20 genes

Gene	meth	rna
CEL	-10795.5	8223
LCT	-12067.5	5657
ALPI	-9000.5	7284
PIR	-6927.5	7367
GUCY2C	-8997.5	5430
AMY2A	-10097.5	690

Click HERE to show all gene set members

All member genes

	meth	rna
ALPI	-9000.5	7284
AMY2A	-10097.5	690
AMY2B	-9853.5	-6094
CEL	-10795.5	8223
CHIA	-10733.5	-6735
CHIT1	-11831.5	-4108
GUCY2C	-8997.5	5430
LCT	-12067.5	5657
MGAM	-11464.5	-579
PIR	-6927.5	7367
TREH	-9220.5	-1459

---

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

metric	value
setSize	10
pMANOVA	0.000468
p.adjustMANOVA	0.0018
s.dist	0.706
s.meth	0.338
s.rna	0.62
p.meth	0.0641
p.rna	0.000692

Top 20 genes

Gene	meth	rna
SNRPE	863.5	8271
ZNF473	2108.5	3348
SNRPD3	983.5	6760
LSM10	400.5	816

Click HERE to show all gene set members

All member genes

	meth	rna
LSM10	400.5	816
LSM11	-452.5	3985
NCBP1	-3393.5	5214
NCBP2	-3762.5	6970
SNRPB	-8813.5	7502
SNRPD3	983.5	6760
SNRPE	863.5	8271
SNRPF	-2097.5	7995
SNRPG	-1738.5	8143
ZNF473	2108.5	3348

---

---

Polo-like kinase mediated events

Polo-like kinase mediated events

metric	value
setSize	16
pMANOVA	9.21e-06
p.adjustMANOVA	5.87e-05
s.dist	0.697
s.meth	-0.0747
s.rna	0.693
p.meth	0.605
p.rna	1.58e-06

Top 20 genes

Gene	meth	rna
MYBL2	-10566.5	8996
PLK1	-10436.5	8851
CCNB1	-8748.5	8885
CENPF	-8600.5	8947
CDC25C	-7531.5	8932
FOXM1	-5899.5	8915
CDC25A	-5154.5	8956
LIN9	-5824.5	7727
CCNB2	-4543.5	8890
PKMYT1	-2617.5	8187
WEE1	-5935.5	3190
LIN54	-2284.5	4841
RBBP4	-941.5	5827
LIN52	-1004.5	4123

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-8748.5	8885
CCNB2	-4543.5	8890
CDC25A	-5154.5	8956
CDC25C	-7531.5	8932
CENPF	-8600.5	8947
EP300	-435.5	-1181
FOXM1	-5899.5	8915
LIN37	1121.5	-94
LIN52	-1004.5	4123
LIN54	-2284.5	4841
LIN9	-5824.5	7727
MYBL2	-10566.5	8996
PKMYT1	-2617.5	8187
PLK1	-10436.5	8851
RBBP4	-941.5	5827
WEE1	-5935.5	3190

---

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

metric	value
setSize	11
pMANOVA	0.000305
p.adjustMANOVA	0.00124
s.dist	0.692
s.meth	0.304
s.rna	0.622
p.meth	0.0814
p.rna	0.000354

Top 20 genes

Gene	meth	rna
SNRPE	863.5	8271
ZNF473	2108.5	3348
SNRPD3	983.5	6760
LSM10	400.5	816

Click HERE to show all gene set members

All member genes

	meth	rna
LSM10	400.5	816
LSM11	-452.5	3985
NCBP1	-3393.5	5214
NCBP2	-3762.5	6970
SLBP	-4706.5	6117
SNRPB	-8813.5	7502
SNRPD3	983.5	6760
SNRPE	863.5	8271
SNRPF	-2097.5	7995
SNRPG	-1738.5	8143
ZNF473	2108.5	3348

---

---

Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere

metric	value
setSize	25
pMANOVA	1.48e-08
p.adjustMANOVA	2.02e-07
s.dist	0.691
s.meth	0.063
s.rna	0.689
p.meth	0.586
p.rna	2.5e-09

Top 20 genes

Gene	meth	rna
CENPI	0.5	8882
CENPA	0.5	8749

Click HERE to show all gene set members

All member genes

	meth	rna
CENPA	0.5	8749
CENPC	-3517.5	-703
CENPH	-4373.5	8554
CENPI	0.5	8882
CENPK	-4057.5	8658
CENPL	-4813.5	8436
CENPM	-7198.5	8616
CENPN	-8632.5	7950
CENPO	-6003.5	8232
CENPP	-450.5	8470
CENPQ	-757.5	8042
CENPT	-326.5	-400
CENPW	-7253.5	8810
H2AFX	-327.5	8468
HJURP	-8274.5	8993
ITGB3BP	-6351.5	6780
MIS18A	-8838.5	8567
MIS18BP1	-881.5	1585
NPM1	-6169.5	8126
OIP5	-4207.5	8550
RBBP4	-941.5	5827
RBBP7	-141.5	6906
RSF1	-4622.5	3062
RUVBL1	-8575.5	6818
SMARCA5	741.5	-4510

---

---

Nucleosome assembly

Nucleosome assembly

metric	value
setSize	25
pMANOVA	1.48e-08
p.adjustMANOVA	2.02e-07
s.dist	0.691
s.meth	0.063
s.rna	0.689
p.meth	0.586
p.rna	2.5e-09

Top 20 genes

Gene	meth	rna
CENPI	0.5	8882
CENPA	0.5	8749

Click HERE to show all gene set members

All member genes

	meth	rna
CENPA	0.5	8749
CENPC	-3517.5	-703
CENPH	-4373.5	8554
CENPI	0.5	8882
CENPK	-4057.5	8658
CENPL	-4813.5	8436
CENPM	-7198.5	8616
CENPN	-8632.5	7950
CENPO	-6003.5	8232
CENPP	-450.5	8470
CENPQ	-757.5	8042
CENPT	-326.5	-400
CENPW	-7253.5	8810
H2AFX	-327.5	8468
HJURP	-8274.5	8993
ITGB3BP	-6351.5	6780
MIS18A	-8838.5	8567
MIS18BP1	-881.5	1585
NPM1	-6169.5	8126
OIP5	-4207.5	8550
RBBP4	-941.5	5827
RBBP7	-141.5	6906
RSF1	-4622.5	3062
RUVBL1	-8575.5	6818
SMARCA5	741.5	-4510

---

---

Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

metric	value
setSize	20
pMANOVA	7.37e-07
p.adjustMANOVA	6.59e-06
s.dist	0.677
s.meth	-0.321
s.rna	-0.596
p.meth	0.0128
p.rna	3.88e-06

Top 20 genes

Gene	meth	rna
HLA-DRA	-12328.5	-6834
HLA-DQA2	-12215.5	-6192
PAG1	-11450.5	-6480
HLA-DQA1	-9790.5	-6766
HLA-DQB2	-9662.5	-6275
PTPRC	-11569.5	-5132
PTPRJ	-11923.5	-4076
PTPN22	-10670.5	-4550
CD4	-7389.5	-5398
HLA-DPA1	-5298.5	-6741
HLA-DPB1	-3198.5	-6655
CD247	-10560.5	-1214
HLA-DQB1	-1771.5	-6855

Click HERE to show all gene set members

All member genes

	meth	rna
CD247	-10560.5	-1214
CD3D	-1208.5	2746
CD3E	-3852.5	762
CD3G	-2986.5	401
CD4	-7389.5	-5398
CSK	-9318.5	1789
HLA-DPA1	-5298.5	-6741
HLA-DPB1	-3198.5	-6655
HLA-DQA1	-9790.5	-6766
HLA-DQA2	-12215.5	-6192
HLA-DQB1	-1771.5	-6855
HLA-DQB2	-9662.5	-6275
HLA-DRA	-12328.5	-6834
HLA-DRB1	181.5	-6897
HLA-DRB5	1149.5	-6972
LCK	-5683.5	718
PAG1	-11450.5	-6480
PTPN22	-10670.5	-4550
PTPRC	-11569.5	-5132
PTPRJ	-11923.5	-4076

---

---

Response to metal ions

Response to metal ions

metric	value
setSize	11
pMANOVA	0.000738
p.adjustMANOVA	0.00269
s.dist	0.663
s.meth	0.66
s.rna	-0.0531
p.meth	0.000149
p.rna	0.761

Top 20 genes

Gene	meth	rna
CSRP1	3129.5	-6548
MT1M	3453.5	-4342
MT1E	3529.5	-2131
MT1A	1162.5	-1835
MT2A	2638.5	-806

Click HERE to show all gene set members

All member genes

	meth	rna
CSRP1	3129.5	-6548
MT1A	1162.5	-1835
MT1E	3529.5	-2131
MT1F	505.5	1599
MT1G	3171.5	1647
MT1H	1203.5	4094
MT1M	3453.5	-4342
MT1X	-2575.5	7098
MT2A	2638.5	-806
MTF1	-7438.5	-2249
SNCB	2685.5	7927

---

---

Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis

metric	value
setSize	11
pMANOVA	0.000787
p.adjustMANOVA	0.00282
s.dist	0.655
s.meth	0.108
s.rna	0.646
p.meth	0.535
p.rna	0.000208

Top 20 genes

Gene	meth	rna
GMPS	2061.5	8510
GART	1036.5	8110
PFAS	1282.5	5035

Click HERE to show all gene set members

All member genes

	meth	rna
ADSL	-6244.5	5997
ADSS	-2902.5	5832
ADSSL1	-11966.5	4930
ATIC	-10934.5	5732
GART	1036.5	8110
GMPS	2061.5	8510
IMPDH1	1652.5	-1196
IMPDH2	-831.5	6718
PAICS	-4905.5	8748
PFAS	1282.5	5035
PPAT	-6433.5	8846

---

---

G1/S-Specific Transcription

G1/S-Specific Transcription

metric	value
setSize	29
pMANOVA	1.05e-08
p.adjustMANOVA	1.5e-07
s.dist	0.648
s.meth	0.0483
s.rna	0.647
p.meth	0.653
p.rna	1.65e-09

Top 20 genes

Gene	meth	rna
CDC6	1008.5	8984
CCNA1	3593.5	1191
ORC1	428.5	8818
HDAC1	433.5	7947
E2F4	1630.5	574

Click HERE to show all gene set members

All member genes

	meth	rna
CCNA1	3593.5	1191
CCNE1	-4288.5	8705
CDC25A	-5154.5	8956
CDC45	-9051.5	8968
CDC6	1008.5	8984
CDK1	-1046.5	8760
CDT1	-10544.5	8764
DHFR	-4637.5	6990
E2F1	-4007.5	5709
E2F4	1630.5	574
E2F5	-6572.5	211
E2F6	-4579.5	5666
FBXO5	-6535.5	8767
HDAC1	433.5	7947
LIN37	1121.5	-94
LIN52	-1004.5	4123
LIN54	-2284.5	4841
LIN9	-5824.5	7727
ORC1	428.5	8818
PCNA	-4692.5	8487
POLA1	-4762.5	6653
RBBP4	-941.5	5827
RBL1	-9441.5	8395
RBL2	-5159.5	-3756
RRM2	-4022.5	8971
TFDP1	-9047.5	4673
TFDP2	-9864.5	5132
TK1	-185.5	8636
TYMS	-9375.5	8717

---

---

Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication

metric	value
setSize	10
pMANOVA	0.00175
p.adjustMANOVA	0.00567
s.dist	0.647
s.meth	0.116
s.rna	0.637
p.meth	0.525
p.rna	0.00049

Top 20 genes

Gene	meth	rna
ORC1	428.5	8818
KPNB1	198.5	7604

Click HERE to show all gene set members

All member genes

	meth	rna
H2AFX	-327.5	8468
KPNA1	-11385.5	7560
KPNA6	-2652.5	2763
KPNB1	198.5	7604
ORC1	428.5	8818
ORC2	-4921.5	5499
ORC3	-6515.5	3222
ORC4	-648.5	309
ORC5	-4189.5	7212
ORC6	-4026.5	8938

---

---

Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation

metric	value
setSize	10
pMANOVA	0.00242
p.adjustMANOVA	0.00749
s.dist	0.643
s.meth	0.462
s.rna	-0.448
p.meth	0.0114
p.rna	0.0143

Top 20 genes

Gene	meth	rna
TXNIP	3621.5	-6844
FOXO4	2126.5	-6423
FOXO3	2720.5	-4632

Click HERE to show all gene set members

All member genes

	meth	rna
CREBBP	-351.5	-102
EP300	-435.5	-1181
FOXO1	-3980.5	1142
FOXO3	2720.5	-4632
FOXO4	2126.5	-6423
KAT2B	-1072.5	-6299
SIRT1	-6366.5	-4703
SIRT3	-1775.5	-4946
TXN	-269.5	5811
TXNIP	3621.5	-6844

---

---

Defective GALNT3 causes HFTC

Defective GALNT3 causes HFTC

metric	value
setSize	16
pMANOVA	4.76e-05
p.adjustMANOVA	0.000244
s.dist	0.642
s.meth	-0.641
s.rna	-0.0477
p.meth	9.1e-06
p.rna	0.741

Top 20 genes

Gene	meth	rna
MUC15	-11285.5	-6246
MUC21	-12086.5	-4599
MUC6	-12278.5	-3956
MUC12	-7267.5	-1888
MUC5AC	-10673.5	-982
MUC3A	-3655.5	-2715
MUC5B	-12459.5	-48

Click HERE to show all gene set members

All member genes

	meth	rna
GALNT3	-11186.5	4215
MUC1	2439.5	-5702
MUC12	-7267.5	-1888
MUC13	-11466.5	4209
MUC15	-11285.5	-6246
MUC16	-11173.5	3799
MUC17	-11369.5	6196
MUC20	-10014.5	2785
MUC21	-12086.5	-4599
MUC3A	-3655.5	-2715
MUC4	-10026.5	1633
MUC5AC	-10673.5	-982
MUC5B	-12459.5	-48
MUC6	-12278.5	-3956
MUC7	-11565.5	6932
MUCL1	-9297.5	3550

---

---

Nucleotide biosynthesis

Nucleotide biosynthesis

metric	value
setSize	14
pMANOVA	0.000164
p.adjustMANOVA	0.000726
s.dist	0.642
s.meth	0.0762
s.rna	0.637
p.meth	0.622
p.rna	3.65e-05

Top 20 genes

Gene	meth	rna
GMPS	2061.5	8510
GART	1036.5	8110
PFAS	1282.5	5035
DHODH	319.5	1950

Click HERE to show all gene set members

All member genes

	meth	rna
ADSL	-6244.5	5997
ADSS	-2902.5	5832
ADSSL1	-11966.5	4930
ATIC	-10934.5	5732
CAD	-9106.5	7607
DHODH	319.5	1950
GART	1036.5	8110
GMPS	2061.5	8510
IMPDH1	1652.5	-1196
IMPDH2	-831.5	6718
PAICS	-4905.5	8748
PFAS	1282.5	5035
PPAT	-6433.5	8846
UMPS	-5258.5	7791

---

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

metric	value
setSize	13
pMANOVA	0.000322
p.adjustMANOVA	0.0013
s.dist	0.641
s.meth	0.0353
s.rna	0.64
p.meth	0.826
p.rna	6.46e-05

Top 20 genes

Gene	meth	rna
CHEK2	2049.5	8913
YWHAE	1372.5	3337

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-8748.5	8885
CDC25C	-7531.5	8932
CDK1	-1046.5	8760
CHEK1	-4739.5	8838
CHEK2	2049.5	8913
SFN	-11680.5	7584
WEE1	-5935.5	3190
YWHAB	-315.5	4955
YWHAE	1372.5	3337
YWHAG	-6912.5	5087
YWHAH	-2770.5	-3738
YWHAQ	-2395.5	6308
YWHAZ	-4187.5	7804

---

---

Condensation of Prophase Chromosomes

Condensation of Prophase Chromosomes

metric	value
setSize	13
pMANOVA	0.000335
p.adjustMANOVA	0.00134
s.dist	0.638
s.meth	0.0685
s.rna	0.635
p.meth	0.669
p.rna	7.42e-05

Top 20 genes

Gene	meth	rna
RB1	2151.5	482
MCPH1	1523.5	258

Click HERE to show all gene set members

All member genes

	meth	rna
CCNB1	-8748.5	8885
CDK1	-1046.5	8760
H2AFX	-327.5	8468
MCPH1	1523.5	258
NCAPD3	-5362.5	7733
NCAPG2	-5873.5	8624
NCAPH2	520.5	-2516
PHF8	-3754.5	5263
PLK1	-10436.5	8851
RB1	2151.5	482
SET	-9018.5	6867
SMC2	-3394.5	8181
SMC4	-5551.5	8439

---

---

Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse

metric	value
setSize	17
pMANOVA	2.74e-05
p.adjustMANOVA	0.000155
s.dist	0.635
s.meth	-0.232
s.rna	-0.591
p.meth	0.0974
p.rna	2.43e-05

Top 20 genes

Gene	meth	rna
HLA-DRA	-12328.5	-6834
HLA-DQA2	-12215.5	-6192
HLA-DQA1	-9790.5	-6766
HLA-DQB2	-9662.5	-6275
PTPN22	-10670.5	-4550
CD4	-7389.5	-5398
HLA-DPA1	-5298.5	-6741
HLA-DPB1	-3198.5	-6655
CD247	-10560.5	-1214
ZAP70	-10958.5	-1113
HLA-DQB1	-1771.5	-6855

Click HERE to show all gene set members

All member genes

	meth	rna
CD247	-10560.5	-1214
CD3D	-1208.5	2746
CD3E	-3852.5	762
CD3G	-2986.5	401
CD4	-7389.5	-5398
HLA-DPA1	-5298.5	-6741
HLA-DPB1	-3198.5	-6655
HLA-DQA1	-9790.5	-6766
HLA-DQA2	-12215.5	-6192
HLA-DQB1	-1771.5	-6855
HLA-DQB2	-9662.5	-6275
HLA-DRA	-12328.5	-6834
HLA-DRB1	181.5	-6897
HLA-DRB5	1149.5	-6972
LCK	-5683.5	718
PTPN22	-10670.5	-4550
ZAP70	-10958.5	-1113

---

---

PRC2 methylates histones and DNA

PRC2 methylates histones and DNA

metric	value
setSize	14
pMANOVA	0.000195
p.adjustMANOVA	0.000842
s.dist	0.635
s.meth	0.105
s.rna	0.626
p.meth	0.496
p.rna	5.02e-05

Top 20 genes

Gene	meth	rna
DNMT3A	1442.5	5421
EED	924.5	7313

Click HERE to show all gene set members

All member genes

	meth	rna
AEBP2	-6580.5	6870
DNMT1	-6290.5	7696
DNMT3A	1442.5	5421
DNMT3B	-6732.5	8432
EED	924.5	7313
EZH2	-8904.5	8832
H2AFX	-327.5	8468
JARID2	-9803.5	4090
MTF2	-2415.5	5645
PHF1	-189.5	-5176
PHF19	-1748.5	4862
RBBP4	-941.5	5827
RBBP7	-141.5	6906
SUZ12	-7206.5	8116

---

---

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

metric	value
setSize	23
pMANOVA	1.09e-06
p.adjustMANOVA	9.09e-06
s.dist	0.628
s.meth	0.111
s.rna	0.618
p.meth	0.358
p.rna	2.91e-07

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RBBP8	2353.5	7388
RMI1	-1281.5	6914
RMI2	2178.5	7204
TOP3A	-3422.5	6031
WRN	-642.5	5521
XRCC2	2853.5	8835

---

---

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

metric	value
setSize	23
pMANOVA	1.09e-06
p.adjustMANOVA	9.09e-06
s.dist	0.628
s.meth	0.111
s.rna	0.618
p.meth	0.358
p.rna	2.91e-07

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RBBP8	2353.5	7388
RMI1	-1281.5	6914
RMI2	2178.5	7204
TOP3A	-3422.5	6031
WRN	-642.5	5521
XRCC2	2853.5	8835

---

---

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

metric	value
setSize	23
pMANOVA	1.09e-06
p.adjustMANOVA	9.09e-06
s.dist	0.628
s.meth	0.111
s.rna	0.618
p.meth	0.358
p.rna	2.91e-07

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RBBP8	2353.5	7388
RMI1	-1281.5	6914
RMI2	2178.5	7204
TOP3A	-3422.5	6031
WRN	-642.5	5521
XRCC2	2853.5	8835

---

---

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

metric	value
setSize	23
pMANOVA	1.09e-06
p.adjustMANOVA	9.09e-06
s.dist	0.628
s.meth	0.111
s.rna	0.618
p.meth	0.358
p.rna	2.91e-07

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RBBP8	2353.5	7388
RMI1	-1281.5	6914
RMI2	2178.5	7204
TOP3A	-3422.5	6031
WRN	-642.5	5521
XRCC2	2853.5	8835

---

---

Impaired BRCA2 binding to PALB2

Impaired BRCA2 binding to PALB2

metric	value
setSize	23
pMANOVA	1.09e-06
p.adjustMANOVA	9.09e-06
s.dist	0.628
s.meth	0.111
s.rna	0.618
p.meth	0.358
p.rna	2.91e-07

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RBBP8	2353.5	7388
RMI1	-1281.5	6914
RMI2	2178.5	7204
TOP3A	-3422.5	6031
WRN	-642.5	5521
XRCC2	2853.5	8835

---

---

Initial triggering of complement

Initial triggering of complement

metric	value
setSize	19
pMANOVA	1.03e-05
p.adjustMANOVA	6.46e-05
s.dist	0.625
s.meth	-0.446
s.rna	-0.438
p.meth	0.000758
p.rna	0.000952

Top 20 genes

Gene	meth	rna
C1QC	-11195.5	-6580
C1QA	-9671.5	-7061
C1QB	-9564.5	-6836
MASP1	-11634.5	-5609
FCN1	-11447.5	-5579
MASP2	-11354.5	-4069
C3	-10826.5	-3915
CFD	-6030.5	-6545
COLEC10	-9669.5	-3927
C4A	-11858.5	-2840
C4B	-11910.5	-2748
C2	-3995.5	-6856
GZMM	-6126.5	-518

Click HERE to show all gene set members

All member genes

	meth	rna
C1QA	-9671.5	-7061
C1QB	-9564.5	-6836
C1QC	-11195.5	-6580
C1R	498.5	1370
C1S	-5655.5	2425
C2	-3995.5	-6856
C3	-10826.5	-3915
C4A	-11858.5	-2840
C4B	-11910.5	-2748
CFB	-7192.5	1652
CFD	-6030.5	-6545
COLEC10	-9669.5	-3927
COLEC11	-9820.5	7687
FCN1	-11447.5	-5579
FCN2	-7682.5	5204
FCN3	3192.5	-7259
GZMM	-6126.5	-518
MASP1	-11634.5	-5609
MASP2	-11354.5	-4069

---

---

Dectin-2 family

Dectin-2 family

metric	value
setSize	25
pMANOVA	3.2e-07
p.adjustMANOVA	3.11e-06
s.dist	0.625
s.meth	-0.574
s.rna	-0.247
p.meth	6.78e-07
p.rna	0.0328

Top 20 genes

Gene	meth	rna
MUC15	-11285.5	-6246
MUC21	-12086.5	-4599
CLEC4A	-11264.5	-4402
MUC6	-12278.5	-3956
CLEC4E	-11429.5	-3790
CLEC10A	-7319.5	-4477
LYN	-11187.5	-2411
CLEC6A	-5932.5	-4540
FCER1G	-3977.5	-6458
SYK	-6863.5	-2686
MUC12	-7267.5	-1888
MUC5AC	-10673.5	-982
MUC3A	-3655.5	-2715
CLEC4D	-11047.5	-854
FYN	-3031.5	-2351
PLCG2	-11696.5	-384
MUC5B	-12459.5	-48

Click HERE to show all gene set members

All member genes

	meth	rna
CLEC10A	-7319.5	-4477
CLEC4A	-11264.5	-4402
CLEC4D	-11047.5	-854
CLEC4E	-11429.5	-3790
CLEC6A	-5932.5	-4540
FCER1G	-3977.5	-6458
FYN	-3031.5	-2351
LYN	-11187.5	-2411
MUC1	2439.5	-5702
MUC12	-7267.5	-1888
MUC13	-11466.5	4209
MUC15	-11285.5	-6246
MUC16	-11173.5	3799
MUC17	-11369.5	6196
MUC20	-10014.5	2785
MUC21	-12086.5	-4599
MUC3A	-3655.5	-2715
MUC4	-10026.5	1633
MUC5AC	-10673.5	-982
MUC5B	-12459.5	-48
MUC6	-12278.5	-3956
MUC7	-11565.5	6932
MUCL1	-9297.5	3550
PLCG2	-11696.5	-384
SYK	-6863.5	-2686

---

---

Lagging Strand Synthesis

Lagging Strand Synthesis

metric	value
setSize	20
pMANOVA	7.67e-06
p.adjustMANOVA	5e-05
s.dist	0.623
s.meth	0.108
s.rna	0.614
p.meth	0.402
p.rna	2.01e-06

Top 20 genes

Gene	meth	rna
POLA2	2611.5	7700
PRIM1	1943.5	7625
RFC2	890.5	7737
RPA2	1002.5	5584

Click HERE to show all gene set members

All member genes

	meth	rna
DNA2	-4346.5	8434
FEN1	-2132.5	8745
LIG1	-416.5	6552
PCNA	-4692.5	8487
POLA1	-4762.5	6653
POLA2	2611.5	7700
POLD1	-7153.5	4282
POLD2	-2453.5	6109
POLD3	-1734.5	339
POLD4	350.5	-4338
PRIM1	1943.5	7625
PRIM2	-11838.5	8571
RFC1	-5544.5	-460
RFC2	890.5	7737
RFC3	-9533.5	7667
RFC4	-7193.5	8880
RFC5	-1010.5	8266
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891

---

---

Processing and activation of SUMO

Processing and activation of SUMO

metric	value
setSize	10
pMANOVA	0.00273
p.adjustMANOVA	0.00823
s.dist	0.619
s.meth	0.32
s.rna	0.53
p.meth	0.0795
p.rna	0.00373

Top 20 genes

Gene	meth	rna
SAE1	2121.5	5402
RWDD3	3021.5	2797
SENP2	308.5	5281

Click HERE to show all gene set members

All member genes

	meth	rna
RWDD3	3021.5	2797
SAE1	2121.5	5402
SENP1	-4316.5	7741
SENP2	308.5	5281
SENP5	-2110.5	7110
SUMO1	-1742.5	2574
SUMO2	-8114.5	5664
SUMO3	-3735.5	1646
UBA2	-1822.5	7106
UBE2I	-972.5	6338

---

---

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

metric	value
setSize	25
pMANOVA	7.4e-07
p.adjustMANOVA	6.59e-06
s.dist	0.61
s.meth	0.11
s.rna	0.6
p.meth	0.342
p.rna	2.03e-07

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204
XRCC3	1243.5	5933

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RBBP8	2353.5	7388
RMI1	-1281.5	6914
RMI2	2178.5	7204
RTEL1	-8326.5	2263
TOP3A	-3422.5	6031
WRN	-642.5	5521
XRCC2	2853.5	8835
XRCC3	1243.5	5933

---

---

Processive synthesis on the lagging strand

Processive synthesis on the lagging strand

metric	value
setSize	15
pMANOVA	0.00021
p.adjustMANOVA	0.000894
s.dist	0.609
s.meth	0.15
s.rna	0.59
p.meth	0.316
p.rna	7.5e-05

Top 20 genes

Gene	meth	rna
POLA2	2611.5	7700
PRIM1	1943.5	7625
RPA2	1002.5	5584

Click HERE to show all gene set members

All member genes

	meth	rna
DNA2	-4346.5	8434
FEN1	-2132.5	8745
LIG1	-416.5	6552
PCNA	-4692.5	8487
POLA1	-4762.5	6653
POLA2	2611.5	7700
POLD1	-7153.5	4282
POLD2	-2453.5	6109
POLD3	-1734.5	339
POLD4	350.5	-4338
PRIM1	1943.5	7625
PRIM2	-11838.5	8571
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891

---

---

cGMP effects

cGMP effects

metric	value
setSize	15
pMANOVA	0.000218
p.adjustMANOVA	0.000928
s.dist	0.605
s.meth	-0.548
s.rna	-0.256
p.meth	0.000235
p.rna	0.0867

Top 20 genes

Gene	meth	rna
PRKG1	-11016.5	-6464
ITPR1	-11310.5	-5786
PRKG2	-8234.5	-6592
PDE2A	-12240.5	-3903
KCNMB1	-9261.5	-3966
KCNMA1	-12301.5	-2466
PDE9A	-11810.5	-1621
KCNMB4	-7097.5	-2484

Click HERE to show all gene set members

All member genes

	meth	rna
ITPR1	-11310.5	-5786
KCNMA1	-12301.5	-2466
KCNMB1	-9261.5	-3966
KCNMB2	-6309.5	7331
KCNMB3	-11179.5	7819
KCNMB4	-7097.5	-2484
PDE10A	-12097.5	2948
PDE11A	-11687.5	7861
PDE1A	-11509.5	951
PDE1B	2815.5	-6072
PDE2A	-12240.5	-3903
PDE5A	753.5	-6282
PDE9A	-11810.5	-1621
PRKG1	-11016.5	-6464
PRKG2	-8234.5	-6592

---

---

Postmitotic nuclear pore complex (NPC) reformation

Postmitotic nuclear pore complex (NPC) reformation

metric	value
setSize	26
pMANOVA	7.25e-07
p.adjustMANOVA	6.53e-06
s.dist	0.603
s.meth	-0.0305
s.rna	0.602
p.meth	0.788
p.rna	1.06e-07

Top 20 genes

Gene	meth	rna
NUP37	-8683.5	7871
RCC1	-8174.5	8268
NUP133	-10171.5	6536
NUP62	-8973.5	6859
NUP155	-6989.5	8372
RANGAP1	-8438.5	6929
NDC1	-6311.5	8289
NUP43	-7195.5	6952
AHCTF1	-5996.5	8020
TNPO1	-7414.5	5707
NUP107	-4160.5	7021
NUP93	-5963.5	4813
NUP160	-7190.5	3773
NUP35	-3461.5	7111
RAN	-2661.5	8107
NUP85	-3817.5	5047
POM121	-3349.5	2130
UBE2I	-972.5	6338
NUP54	-1024.5	5185
SUMO1	-1742.5	2574

Click HERE to show all gene set members

All member genes

	meth	rna
AHCTF1	-5996.5	8020
KPNB1	198.5	7604
NDC1	-6311.5	8289
NUP107	-4160.5	7021
NUP133	-10171.5	6536
NUP155	-6989.5	8372
NUP160	-7190.5	3773
NUP188	831.5	3417
NUP205	176.5	7164
NUP35	-3461.5	7111
NUP37	-8683.5	7871
NUP43	-7195.5	6952
NUP54	-1024.5	5185
NUP62	-8973.5	6859
NUP85	-3817.5	5047
NUP93	-5963.5	4813
NUP98	-7629.5	-1029
POM121	-3349.5	2130
RAN	-2661.5	8107
RANGAP1	-8438.5	6929
RCC1	-8174.5	8268
SEC13	-2450.5	1322
SEH1L	1919.5	5220
SUMO1	-1742.5	2574
TNPO1	-7414.5	5707
UBE2I	-972.5	6338

---

---

Keratinization

Keratinization

metric	value
setSize	137
pMANOVA	3.27e-32
p.adjustMANOVA	6.15e-30
s.dist	0.603
s.meth	-0.289
s.rna	0.529
p.meth	5.13e-09
p.rna	1.14e-26

Top 20 genes

Gene	meth	rna
KRT5	-12088.5	8904
DSG3	-11252.5	9007
KRT6A	-11103.5	9011
KRT14	-10860.5	8957
KRT6B	-10517.5	8983
KRT17	-10434.5	8777
KRT75	-10329.5	8553
TGM5	-11197.5	7519
KRT31	-9652.5	8505
KRT34	-10101.5	7961
DSC1	-9991.5	8034
KRTAP5-3	-10491.5	7596
DSP	-9491.5	8353
KRT15	-9223.5	8230
KRT16	-8402.5	9009
KRT6C	-8464.5	8927
PI3	-11025.5	6710
KRTAP10-7	-10514.5	7011
KRTAP10-12	-9100.5	7990
PKP1	-8130.5	8765

Click HERE to show all gene set members

All member genes

	meth	rna
CAPN1	-7923.5	553
CAPNS1	-2923.5	-1328
CASP14	-11277.5	4136
CSTA	-9971.5	4279
DSC1	-9991.5	8034
DSC2	-7410.5	6625
DSC3	1515.5	8960
DSG1	-6680.5	8540
DSG2	-4159.5	6876
DSG3	-11252.5	9007
DSG4	-7963.5	7847
DSP	-9491.5	8353
EVPL	-6405.5	-3429
FLG	-11528.5	5091
FURIN	-4358.5	-1635
IVL	-6623.5	7493
JUP	-10589.5	5194
KAZN	-8578.5	-4147
KLK12	-11234.5	4798
KLK13	2865.5	682
KLK14	-3121.5	665
KLK5	-5045.5	67
KRT1	-7910.5	7736
KRT10	-5460.5	7261
KRT12	2360.5	3402
KRT13	-6899.5	6487
KRT14	-10860.5	8957
KRT15	-9223.5	8230
KRT16	-8402.5	9009
KRT17	-10434.5	8777
KRT18	-11603.5	-1999
KRT19	-7873.5	3027
KRT2	-9651.5	6910
KRT20	-8494.5	4249
KRT23	-5441.5	5973
KRT24	-9950.5	3220
KRT26	-10665.5	4608
KRT27	-9123.5	-642
KRT3	-4559.5	7811
KRT31	-9652.5	8505
KRT32	-4278.5	7769
KRT33A	-8320.5	7354
KRT33B	-9025.5	5427
KRT34	-10101.5	7961
KRT35	-8972.5	6697
KRT36	-5582.5	6723
KRT37	-10172.5	5345
KRT4	0.5	-6360
KRT40	-3011.5	1372
KRT5	-12088.5	8904
KRT6A	-11103.5	9011
KRT6B	-10517.5	8983
KRT6C	-8464.5	8927
KRT7	-1100.5	-6412
KRT71	-6991.5	5016
KRT72	3429.5	4892
KRT73	-2429.5	2198
KRT74	-5222.5	8008
KRT75	-10329.5	8553
KRT76	-9169.5	6384
KRT77	1837.5	8082
KRT78	-997.5	7179
KRT79	-3039.5	-3761
KRT8	-12002.5	203
KRT80	-11909.5	2997
KRT81	-1382.5	6229
KRT83	-526.5	8348
KRT85	-1142.5	5902
KRT86	-1836.5	1987
KRT9	-3991.5	7623
KRTAP1-1	-8388.5	5428
KRTAP10-1	-9514.5	7458
KRTAP10-10	-4796.5	7046
KRTAP10-11	-10122.5	6847
KRTAP10-12	-9100.5	7990
KRTAP10-2	-3021.5	6792
KRTAP10-3	-9593.5	6866
KRTAP10-4	-8026.5	6467
KRTAP10-5	-9552.5	7190
KRTAP10-6	2346.5	7063
KRTAP10-7	-10514.5	7011
KRTAP10-8	-9684.5	7081
KRTAP10-9	-9539.5	7208
KRTAP12-1	-10298.5	6006
KRTAP12-2	-10034.5	6937
KRTAP16-1	-7293.5	3887
KRTAP17-1	-1883.5	6904
KRTAP3-3	2802.5	4437
KRTAP4-11	-7802.5	7430
KRTAP4-2	-5113.5	5706
KRTAP4-4	-6464.5	7113
KRTAP4-5	-9189.5	6604
KRTAP4-6	0.5	6215
KRTAP4-7	-7892.5	6213
KRTAP4-8	-8765.5	6614
KRTAP4-9	-4260.5	6754
KRTAP5-1	-6297.5	-126
KRTAP5-10	-7362.5	5519
KRTAP5-11	-10217.5	3671
KRTAP5-2	-10287.5	-5608
KRTAP5-3	-10491.5	7596
KRTAP5-5	-8920.5	6999
KRTAP5-6	-6818.5	4154
KRTAP5-7	-9541.5	3253
KRTAP5-8	-9851.5	4012
KRTAP5-9	-8875.5	5550
KRTAP9-1	-8551.5	6671
KRTAP9-4	-9253.5	4472
KRTAP9-9	-11059.5	5836
LCE1D	0.5	6175
LCE2A	-8311.5	4937
LIPN	-7383.5	-1876
PCSK6	-12264.5	4024
PERP	-6348.5	7084
PI3	-11025.5	6710
PKP1	-8130.5	8765
PKP2	-4077.5	5821
PKP3	-11032.5	5073
PKP4	-4740.5	2289
PPL	-2528.5	-5182
PRSS8	2652.5	-5978
RPTN	-6181.5	8623
SPINK5	-9258.5	6565
SPINK6	-6849.5	7908
SPINK9	-8203.5	-4221
SPRR1A	-5704.5	8664
SPRR1B	-1200.5	8744
SPRR2A	-7791.5	8672
SPRR2D	-3351.5	8171
SPRR2E	0.5	8299
SPRR2F	-911.5	7937
SPRR2G	1062.5	7753
SPRR3	-8238.5	8284
ST14	-11590.5	2306
TCHH	2400.5	6603
TGM1	-9771.5	-690
TGM5	-11197.5	7519

---

---

Defective GALNT12 causes CRCS1

Defective GALNT12 causes CRCS1

metric	value
setSize	16
pMANOVA	0.000155
p.adjustMANOVA	0.000696
s.dist	0.601
s.meth	-0.588
s.rna	-0.123
p.meth	4.63e-05
p.rna	0.393

Top 20 genes

Gene	meth	rna
MUC15	-11285.5	-6246
MUC21	-12086.5	-4599
MUC6	-12278.5	-3956
GALNT12	-4324.5	-5657
MUC12	-7267.5	-1888
MUC5AC	-10673.5	-982
MUC3A	-3655.5	-2715
MUC5B	-12459.5	-48

Click HERE to show all gene set members

All member genes

	meth	rna
GALNT12	-4324.5	-5657
MUC1	2439.5	-5702
MUC12	-7267.5	-1888
MUC13	-11466.5	4209
MUC15	-11285.5	-6246
MUC16	-11173.5	3799
MUC17	-11369.5	6196
MUC20	-10014.5	2785
MUC21	-12086.5	-4599
MUC3A	-3655.5	-2715
MUC4	-10026.5	1633
MUC5AC	-10673.5	-982
MUC5B	-12459.5	-48
MUC6	-12278.5	-3956
MUC7	-11565.5	6932
MUCL1	-9297.5	3550

---

---

Homologous DNA Pairing and Strand Exchange

Homologous DNA Pairing and Strand Exchange

metric	value
setSize	41
pMANOVA	2.24e-10
p.adjustMANOVA	4.61e-09
s.dist	0.599
s.meth	0.0887
s.rna	0.592
p.meth	0.326
p.rna	5.35e-11

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204
XRCC3	1243.5	5933
RFC2	890.5	7737
RPA2	1002.5	5584
ATRIP	1339.5	3743

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
ATR	-6469.5	7826
ATRIP	1339.5	3743
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
CHEK1	-4739.5	8838
DNA2	-4346.5	8434
EXO1	-6157.5	8940
HUS1	-3648.5	1638
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD1	-2144.5	4001
RAD17	-1581.5	-225
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RAD9A	-5228.5	2822
RAD9B	-2394.5	-5
RBBP8	2353.5	7388
RFC2	890.5	7737
RFC3	-9533.5	7667
RFC4	-7193.5	8880
RFC5	-1010.5	8266
RHNO1	-7365.5	5804
RMI1	-1281.5	6914
RMI2	2178.5	7204
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891
TOP3A	-3422.5	6031
TOPBP1	-9303.5	8342
WRN	-642.5	5521
XRCC2	2853.5	8835
XRCC3	1243.5	5933

---

---

Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation

metric	value
setSize	12
pMANOVA	0.00133
p.adjustMANOVA	0.00448
s.dist	0.598
s.meth	0.495
s.rna	0.336
p.meth	0.00298
p.rna	0.0441

Top 20 genes

Gene	meth	rna
WT1	3790.5	8638
FOXL2	3419.5	8410
GATA4	3215.5	7832
DMRT1	2932.5	7565
DHH	3131.5	6447
SOX9	3400.5	3519
AMH	1675.5	6347

Click HERE to show all gene set members

All member genes

	meth	rna
AMH	1675.5	6347
DHH	3131.5	6447
DMRT1	2932.5	7565
FGF9	1695.5	-3882
FOXL2	3419.5	8410
GATA4	3215.5	7832
NR5A1	-3219.5	7520
PTGDS	-3368.5	-6717
SOX9	3400.5	3519
WNT4	-8679.5	1527
WT1	3790.5	8638
ZFPM2	-11691.5	-4238

---

---

Removal of the Flap Intermediate

Removal of the Flap Intermediate

metric	value
setSize	14
pMANOVA	0.000523
p.adjustMANOVA	0.00197
s.dist	0.596
s.meth	0.126
s.rna	0.583
p.meth	0.415
p.rna	0.00016

Top 20 genes

Gene	meth	rna
POLA2	2611.5	7700
PRIM1	1943.5	7625
RPA2	1002.5	5584

Click HERE to show all gene set members

All member genes

	meth	rna
DNA2	-4346.5	8434
FEN1	-2132.5	8745
PCNA	-4692.5	8487
POLA1	-4762.5	6653
POLA2	2611.5	7700
POLD1	-7153.5	4282
POLD2	-2453.5	6109
POLD3	-1734.5	339
POLD4	350.5	-4338
PRIM1	1943.5	7625
PRIM2	-11838.5	8571
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891

---

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

metric	value
setSize	10
pMANOVA	0.00469
p.adjustMANOVA	0.0128
s.dist	0.595
s.meth	0.105
s.rna	0.585
p.meth	0.567
p.rna	0.00135

Top 20 genes

Gene	meth	rna

Click HERE to show all gene set members

All member genes

	meth	rna
ACTB	1716.5	-3414
CCT2	-3926.5	8283
CCT3	-6995.5	8061
CCT4	-6138.5	8451
CCT5	-2085.5	7838
CCT6A	-7934.5	8483
CCT6B	-3818.5	-2240
CCT7	-608.5	7277
CCT8	-2941.5	6019
TCP1	-2255.5	7456

---

---

Presynaptic depolarization and calcium channel opening

Presynaptic depolarization and calcium channel opening

metric	value
setSize	12
pMANOVA	0.00171
p.adjustMANOVA	0.00558
s.dist	0.594
s.meth	-0.592
s.rna	-0.04
p.meth	0.000382
p.rna	0.81

Top 20 genes

Gene	meth	rna
CACNA2D2	-12323.5	-7160
CACNG4	-10213.5	-6962
CACNB4	-7594.5	-4515
CACNB2	-9752.5	-2434
CACNA2D3	-9144.5	-2066
CACNB3	-8462.5	-1620

Click HERE to show all gene set members

All member genes

	meth	rna
CACNA1A	-12320.5	7882
CACNA1B	-9509.5	8526
CACNA1E	-11643.5	7897
CACNA2D1	-11901.5	3702
CACNA2D2	-12323.5	-7160
CACNA2D3	-9144.5	-2066
CACNB1	808.5	-4348
CACNB2	-9752.5	-2434
CACNB3	-8462.5	-1620
CACNB4	-7594.5	-4515
CACNG2	-8227.5	7236
CACNG4	-10213.5	-6962

---

---

Signaling by BMP

Signaling by BMP

metric	value
setSize	24
pMANOVA	4.62e-06
p.adjustMANOVA	3.25e-05
s.dist	0.593
s.meth	0.447
s.rna	-0.389
p.meth	0.000148
p.rna	0.000966

Top 20 genes

Gene	meth	rna
ACVRL1	3729.5	-7229
SMAD7	3711.5	-6722
SMAD6	3714.5	-6120
SKI	3503.5	-5806
BMP2	3113.5	-5889
SMAD4	2047.5	-6169
CHRDL1	1696.5	-6833
BMPR2	1758.5	-6124
SMURF2	2543.5	-4101
BMPR1A	1540.5	-3980
ACVR2B	1325.5	-823

Click HERE to show all gene set members

All member genes

	meth	rna
ACVR2A	-6558.5	-1685
ACVR2B	1325.5	-823
ACVRL1	3729.5	-7229
AMH	1675.5	6347
AMHR2	-4039.5	3684
BMP2	3113.5	-5889
BMPR1A	1540.5	-3980
BMPR1B	-2246.5	-1249
BMPR2	1758.5	-6124
CHRDL1	1696.5	-6833
FSTL1	-3839.5	-18
NOG	3397.5	5522
SKI	3503.5	-5806
SMAD1	-773.5	6594
SMAD4	2047.5	-6169
SMAD5	-952.5	-4073
SMAD6	3714.5	-6120
SMAD7	3711.5	-6722
SMAD9	-6638.5	-6895
SMURF1	-8261.5	-1416
SMURF2	2543.5	-4101
UBE2D1	-9172.5	-308
UBE2D3	-4840.5	-921
ZFYVE16	-3240.5	-1912

---

---

Creation of C4 and C2 activators

Creation of C4 and C2 activators

metric	value
setSize	12
pMANOVA	0.0015
p.adjustMANOVA	0.00502
s.dist	0.592
s.meth	-0.426
s.rna	-0.411
p.meth	0.0106
p.rna	0.0137

Top 20 genes

Gene	meth	rna
C1QC	-11195.5	-6580
C1QA	-9671.5	-7061
C1QB	-9564.5	-6836
MASP1	-11634.5	-5609
FCN1	-11447.5	-5579
MASP2	-11354.5	-4069
COLEC10	-9669.5	-3927

Click HERE to show all gene set members

All member genes

	meth	rna
C1QA	-9671.5	-7061
C1QB	-9564.5	-6836
C1QC	-11195.5	-6580
C1R	498.5	1370
C1S	-5655.5	2425
COLEC10	-9669.5	-3927
COLEC11	-9820.5	7687
FCN1	-11447.5	-5579
FCN2	-7682.5	5204
FCN3	3192.5	-7259
MASP1	-11634.5	-5609
MASP2	-11354.5	-4069

---

---

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

metric	value
setSize	39
pMANOVA	1.61e-09
p.adjustMANOVA	2.85e-08
s.dist	0.586
s.meth	0.0769
s.rna	0.581
p.meth	0.406
p.rna	3.36e-10

Top 20 genes

Gene	meth	rna
XRCC2	2853.5	8835
RBBP8	2353.5	7388
RMI2	2178.5	7204
RFC2	890.5	7737
RPA2	1002.5	5584
ATRIP	1339.5	3743

Click HERE to show all gene set members

All member genes

	meth	rna
ATM	-2298.5	1419
ATR	-6469.5	7826
ATRIP	1339.5	3743
BARD1	-2773.5	7397
BLM	-3189.5	8958
BRCA1	-5429.5	8558
BRCA2	-8094.5	7424
BRIP1	-6553.5	8911
DNA2	-4346.5	8434
EXO1	-6157.5	8940
HUS1	-3648.5	1638
KAT5	328.5	-5691
NBN	-2376.5	1877
PALB2	-3979.5	7694
RAD1	-2144.5	4001
RAD17	-1581.5	-225
RAD50	-8592.5	113
RAD51	-2489.5	8591
RAD51AP1	-6435.5	8733
RAD51B	-7961.5	266
RAD51C	-3721.5	6946
RAD51D	-7298.5	4807
RAD9A	-5228.5	2822
RAD9B	-2394.5	-5
RBBP8	2353.5	7388
RFC2	890.5	7737
RFC3	-9533.5	7667
RFC4	-7193.5	8880
RFC5	-1010.5	8266
RHNO1	-7365.5	5804
RMI1	-1281.5	6914
RMI2	2178.5	7204
RPA1	-5520.5	6281
RPA2	1002.5	5584
RPA3	-7829.5	3891
TOP3A	-3422.5	6031
TOPBP1	-9303.5	8342
WRN	-642.5	5521
XRCC2	2853.5	8835

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      parallel  stats4    stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] dplyr_1.0.9                                        
##  [7] echarts4r_0.4.3                                    
##  [8] kableExtra_1.3.4                                   
##  [9] mitch_1.8.0                                        
## [10] tictoc_1.0.1                                       
## [11] ENmix_1.32.0                                       
## [12] doParallel_1.0.17                                  
## [13] qqman_0.1.8                                        
## [14] RCircos_1.2.2                                      
## [15] beeswarm_0.4.0                                     
## [16] forestplot_2.0.1                                   
## [17] checkmate_2.1.0                                    
## [18] magrittr_2.0.3                                     
## [19] reshape2_1.4.4                                     
## [20] gplots_3.1.3                                       
## [21] eulerr_6.1.1                                       
## [22] GEOquery_2.64.2                                    
## [23] RColorBrewer_1.1-3                                 
## [24] IlluminaHumanMethylation450kmanifest_0.4.0         
## [25] topconfects_1.12.0                                 
## [26] DMRcatedata_2.14.0                                 
## [27] ExperimentHub_2.4.0                                
## [28] AnnotationHub_3.4.0                                
## [29] BiocFileCache_2.4.0                                
## [30] dbplyr_2.1.1                                       
## [31] DMRcate_2.10.0                                     
## [32] limma_3.52.1                                       
## [33] missMethyl_1.30.0                                  
## [34] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [35] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [36] minfi_1.42.0                                       
## [37] bumphunter_1.38.0                                  
## [38] locfit_1.5-9.5                                     
## [39] iterators_1.0.14                                   
## [40] foreach_1.5.2                                      
## [41] Biostrings_2.64.0                                  
## [42] XVector_0.36.0                                     
## [43] SummarizedExperiment_1.26.1                        
## [44] Biobase_2.56.0                                     
## [45] MatrixGenerics_1.8.0                               
## [46] matrixStats_0.62.0                                 
## [47] GenomicRanges_1.48.0                               
## [48] GenomeInfoDb_1.32.2                                
## [49] IRanges_2.30.0                                     
## [50] S4Vectors_0.34.0                                   
## [51] BiocGenerics_0.42.0                                
## [52] R.utils_2.11.0                                     
## [53] R.oo_1.24.0                                        
## [54] R.methodsS3_1.8.1                                  
## [55] plyr_1.8.7                                         
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] jquerylib_0.1.4               hms_1.1.1                    
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             labeling_0.4.2               
##  [61] edgeR_3.38.1                  pkgconfig_2.0.3              
##  [63] nlme_3.1-157                  ProtGenerics_1.28.0          
##  [65] nnet_7.3-17                   rlang_1.0.2                  
##  [67] lifecycle_1.0.1               filelock_1.0.2               
##  [69] dichromat_2.0-0.1             rprojroot_2.0.3              
##  [71] cellranger_1.1.0              rngtools_1.5.2               
##  [73] base64_2.0                    Matrix_1.4-1                 
##  [75] Rhdf5lib_1.18.2               base64enc_0.1-3              
##  [77] viridisLite_0.4.0             png_0.1-7                    
##  [79] rjson_0.2.21                  bitops_1.0-7                 
##  [81] KernSmooth_2.23-20            rhdf5filters_1.8.0           
##  [83] blob_1.2.3                    DelayedMatrixStats_1.18.0    
##  [85] doRNG_1.8.2                   stringr_1.4.0                
##  [87] nor1mix_1.3-0                 readr_2.1.2                  
##  [89] jpeg_0.1-9                    scales_1.2.0                 
##  [91] memoise_2.0.1                 zlibbioc_1.42.0              
##  [93] compiler_4.2.0                BiocIO_1.6.0                 
##  [95] illuminaio_0.38.0             Rsamtools_2.12.0             
##  [97] cli_3.3.0                     DSS_2.44.0                   
##  [99] htmlTable_2.4.0               Formula_1.2-4                
## [101] MASS_7.3-57                   tidyselect_1.1.2             
## [103] stringi_1.7.6                 highr_0.9                    
## [105] yaml_2.3.5                    askpass_1.1                  
## [107] latticeExtra_0.6-29           sass_0.4.1                   
## [109] VariantAnnotation_1.42.1      tools_4.2.0                  
## [111] rstudioapi_0.13               foreign_0.8-82               
## [113] bsseq_1.32.0                  gridExtra_2.3                
## [115] farver_2.1.0                  digest_0.6.29                
## [117] BiocManager_1.30.17           shiny_1.7.1                  
## [119] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [121] siggenes_1.70.0               BiocVersion_3.15.2           
## [123] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [125] httr_1.4.3                    AnnotationDbi_1.58.0         
## [127] biovizBase_1.44.0             colorspace_2.0-3             
## [129] brio_1.1.3                    rvest_1.0.2                  
## [131] XML_3.99-0.9                  splines_4.2.0                
## [133] statmod_1.4.36                multtest_2.52.0              
## [135] systemfonts_1.0.4             xtable_1.8-4                 
## [137] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [139] testthat_3.1.4                R6_2.5.1                     
## [141] Hmisc_4.7-0                   pillar_1.7.0                 
## [143] htmltools_0.5.2               mime_0.12                    
## [145] glue_1.6.2                    fastmap_1.1.0                
## [147] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [149] beanplot_1.3.1                codetools_0.2-18             
## [151] utf8_1.2.2                    bslib_0.3.1                  
## [153] lattice_0.20-45               curl_4.3.2                   
## [155] openssl_2.0.1                 survival_3.3-1               
## [157] rmarkdown_2.14                desc_1.4.1                   
## [159] munsell_0.5.0                 rhdf5_2.40.0                 
## [161] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [163] impute_1.70.0                 gtable_0.3.0

END of report