This code is available at https://github.com/aaronsk7/guppy-methylation
This script performs enrichment analysis of methylkit results.
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## anyMissing, rowMedianslibrary("clusterProfiler")## ## clusterProfiler v4.0.5 For help: https://yulab-smu.top/biomedical-knowledge-mining-book/
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## If you use clusterProfiler in published research, please cite:
## T Wu, E Hu, S Xu, M Chen, P Guo, Z Dai, T Feng, L Zhou, W Tang, L Zhan, X Fu, S Liu, X Bo, and G Yu. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. The Innovation. 2021, 2(3):100141. doi: 10.1016/j.xinn.2021.100141##
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## vennImport promoter differential methylation data.
Import the gene sets.
CvG <- readRDS("CvGtiles_genepromoters.rds")
CvL <- readRDS("CvLtiles_genepromoters.rds")
GvL <- readRDS("GvLtiles_genepromoters.rds")
head(CvG)## seqnames start end width strand pvalue qvalue
## 86983 LG4 1847001 1848000 1000 * 9.714622e-131 4.885614e-125
## 86984 LG4 1847001 1848000 1000 * 9.714622e-131 4.885614e-125
## 86981 LG4 1846001 1847000 1000 * 1.196917e-89 3.009727e-84
## 86982 LG4 1846001 1847000 1000 * 1.196917e-89 3.009727e-84
## 6509 LG1 9073001 9074000 1000 * 3.550053e-47 2.550528e-42
## 8294 LG1 17897001 17898000 1000 * 1.654721e-42 9.246461e-38
## meth.diff gene_id V6 gene_name
## 86983 19.239478 ENSPREG00000021468 ENSPRET00000032035 gpc5b
## 86984 19.239478 ENSPREG00000021490 ENSPRET00000032090 nasp
## 86981 19.897694 ENSPREG00000021468 ENSPRET00000032035 gpc5b
## 86982 19.897694 ENSPREG00000021490 ENSPRET00000032090 nasp
## 6509 14.606176 ENSPREG00000000312 ENSPRET00000000435 slx4
## 8294 -6.231157 ENSPREG00000004582 ENSPRET00000006703 uncharacterisedhead(CvL)## seqnames start end width strand pvalue qvalue
## 63161 LG2 20995001 20996000 1000 * 4.065070e-48 2.956357e-43
## 106383 LG7 18259001 18260000 1000 * 8.559718e-41 4.357590e-36
## 20949 LG11 28461001 28462000 1000 * 1.078697e-40 4.992221e-36
## 70661 LG21 538001 539000 1000 * 5.735034e-40 2.432998e-35
## 31311 LG14 4148001 4149000 1000 * 8.688214e-40 3.402312e-35
## 20618 LG11 27368001 27369000 1000 * 1.892756e-31 4.588411e-27
## meth.diff gene_id V6 gene_name
## 63161 -20.26683 ENSPREG00000014846 ENSPRET00000022204 zgc:194275
## 106383 23.29152 ENSPREG00000003617 ENSPRET00000005305 uts2a
## 20949 -13.62358 ENSPREG00000010182 ENSPRET00000015234 tfap2e
## 70661 -13.78305 ENSPREG00000012722 ENSPRET00000019142 uncharacterised
## 31311 -21.04322 ENSPREG00000009393 ENSPRET00000014038 zgc:112437
## 20618 13.36592 ENSPREG00000008406 ENSPRET00000012667 fabp10bhead(GvL)## seqnames start end width strand pvalue qvalue
## 88849 LG4 1847001 1848000 1000 * 7.503577e-141 3.921253e-135
## 88850 LG4 1847001 1848000 1000 * 7.503577e-141 3.921253e-135
## 88847 LG4 1846001 1847000 1000 * 8.017760e-104 2.094979e-98
## 88848 LG4 1846001 1847000 1000 * 8.017760e-104 2.094979e-98
## 72353 LG21 538001 539000 1000 * 5.180641e-40 4.512205e-35
## 32069 LG14 4148001 4149000 1000 * 2.644311e-35 1.727345e-30
## meth.diff gene_id transcript_id gene_name
## 88849 -19.01626 ENSPREG00000021468 ENSPRET00000032035 gpc5b
## 88850 -19.01626 ENSPREG00000021490 ENSPRET00000032090 nasp
## 88847 -19.30979 ENSPREG00000021468 ENSPRET00000032035 gpc5b
## 88848 -19.30979 ENSPREG00000021490 ENSPRET00000032090 nasp
## 72353 -12.60888 ENSPREG00000012722 ENSPRET00000019142 uncharacterised
## 32069 -17.15105 ENSPREG00000009393 ENSPRET00000014038 zgc:112437Downloaded from ensembl biomart on 8th October 2021. http://www.ensembl.org/biomart/martview/98242811709db7335e2470900eef0f89
#go <- read.table("mart_export.txt.gz",fill=TRUE,sep="\t")
go <- readLines("mart_export.txt.gz")
#go <- head(go,1000)
head(go)## [1] "Gene stable ID\tGene stable ID version\tTranscript stable ID\tTranscript stable ID version\tGO term accession\tGO term name\tGO term definition\tGO domain\tGO term evidence code\tGOSlim GOA Accession(s)\tGOSlim GOA Description"
## [2] "ENSPREG00000000007\tENSPREG00000000007.1\tENSPRET00000000007\tENSPRET00000000007.1\tGO:0008137\tNADH dehydrogenase (ubiquinone) activity\tCatalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).\tmolecular_function\tIEA\tGO:0003674\tmolecular_function"
## [3] "ENSPREG00000000007\tENSPREG00000000007.1\tENSPRET00000000007\tENSPRET00000000007.1\tGO:0005739\tmitochondrion\tA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.\tcellular_component\tIEA\tGO:0003674\tmolecular_function"
## [4] "ENSPREG00000000007\tENSPREG00000000007.1\tENSPRET00000000007\tENSPRET00000000007.1\tGO:0016020\tmembrane\tA lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.\tcellular_component\tIEA\tGO:0003674\tmolecular_function"
## [5] "ENSPREG00000000007\tENSPREG00000000007.1\tENSPRET00000000007\tENSPRET00000000007.1\tGO:0016021\tintegral component of membrane\tThe component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.\tcellular_component\tIEA\tGO:0003674\tmolecular_function"
## [6] "ENSPREG00000000007\tENSPREG00000000007.1\tENSPRET00000000007\tENSPRET00000000007.1\tGO:0005743\tmitochondrial inner membrane\tThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.\tcellular_component\tIEA\tGO:0003674\tmolecular_function"gol <- (strsplit(go,"\t"))
head(gol)## [[1]]
## [1] "Gene stable ID" "Gene stable ID version"
## [3] "Transcript stable ID" "Transcript stable ID version"
## [5] "GO term accession" "GO term name"
## [7] "GO term definition" "GO domain"
## [9] "GO term evidence code" "GOSlim GOA Accession(s)"
## [11] "GOSlim GOA Description"
##
## [[2]]
## [1] "ENSPREG00000000007"
## [2] "ENSPREG00000000007.1"
## [3] "ENSPRET00000000007"
## [4] "ENSPRET00000000007.1"
## [5] "GO:0008137"
## [6] "NADH dehydrogenase (ubiquinone) activity"
## [7] "Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out)."
## [8] "molecular_function"
## [9] "IEA"
## [10] "GO:0003674"
## [11] "molecular_function"
##
## [[3]]
## [1] "ENSPREG00000000007"
## [2] "ENSPREG00000000007.1"
## [3] "ENSPRET00000000007"
## [4] "ENSPRET00000000007.1"
## [5] "GO:0005739"
## [6] "mitochondrion"
## [7] "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration."
## [8] "cellular_component"
## [9] "IEA"
## [10] "GO:0003674"
## [11] "molecular_function"
##
## [[4]]
## [1] "ENSPREG00000000007"
## [2] "ENSPREG00000000007.1"
## [3] "ENSPRET00000000007"
## [4] "ENSPRET00000000007.1"
## [5] "GO:0016020"
## [6] "membrane"
## [7] "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it."
## [8] "cellular_component"
## [9] "IEA"
## [10] "GO:0003674"
## [11] "molecular_function"
##
## [[5]]
## [1] "ENSPREG00000000007"
## [2] "ENSPREG00000000007.1"
## [3] "ENSPRET00000000007"
## [4] "ENSPRET00000000007.1"
## [5] "GO:0016021"
## [6] "integral component of membrane"
## [7] "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane."
## [8] "cellular_component"
## [9] "IEA"
## [10] "GO:0003674"
## [11] "molecular_function"
##
## [[6]]
## [1] "ENSPREG00000000007"
## [2] "ENSPREG00000000007.1"
## [3] "ENSPRET00000000007"
## [4] "ENSPRET00000000007.1"
## [5] "GO:0005743"
## [6] "mitochondrial inner membrane"
## [7] "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae."
## [8] "cellular_component"
## [9] "IEA"
## [10] "GO:0003674"
## [11] "molecular_function"godf <- do.call(rbind,gol)
colnames(godf) <- godf[1,]
godf <- godf[2:nrow(godf),]
gos <- unique(godf[,"GO term accession"])
mysets <- lapply(gos,function(x) { unique(godf[which(x == godf[,"GO term accession"]),1]) } )
mynames <- sapply(gos,function(x) { unname(godf[head(which(x == godf[,"GO term accession"] ),1),"GO term name"] ) } )
mynames <- paste(gos,mynames)
names(mysets) <- mynamesThis might take a few minutes - get a cuppa.
CvG$score <- sign(CvG$meth.diff)/-log(CvG$pvalue)
CvG[is.na(CvG$score),"score"] <- 0
pp <- CvG[,c("gene_id","score")]
pp <- subset(pp, !duplicated(pp$gene_id))
rownames(pp) <- pp$gene_id
pp$gene_id=NULL
head(pp)## score
## ENSPREG00000021468 0.003340404
## ENSPREG00000021490 0.003340404
## ENSPREG00000000312 0.009349767
## ENSPREG00000004582 -0.010394476
## ENSPREG00000004594 -0.010394476
## ENSPREG00000003390 -0.013098962res <- mitch_calc(x=pp,genesets=mysets,resrows=50)## Note: When prioritising by significance (ie: small
## p-values), large effect sizes might be missed.head(res$enrichment_result,15)## set setSize
## 794 GO:0051087 chaperone binding 12
## 983 GO:0005833 hemoglobin complex 12
## 303 GO:0006289 nucleotide-excision repair 13
## 596 GO:0030509 BMP signaling pathway 21
## 532 GO:0004879 nuclear receptor activity 38
## 521 GO:0001947 heart looping 72
## 214 GO:0005525 GTP binding 450
## 622 GO:0043231 intracellular membrane-bounded organelle 17
## 139 GO:0043065 positive regulation of apoptotic process 21
## 259 GO:0008033 tRNA processing 52
## 190 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 31
## 533 GO:0030522 intracellular receptor signaling pathway 27
## 980 GO:0005344 oxygen carrier activity 16
## 981 GO:0019825 oxygen binding 16
## 982 GO:0015671 oxygen transport 16
## pANOVA s.dist p.adjustANOVA
## 794 0.0001734901 -0.62590559 0.1715817
## 983 0.0003834717 -0.59197986 0.1896268
## 303 0.0007118686 -0.54215119 0.2094426
## 596 0.0008470885 -0.42058856 0.2094426
## 532 0.0016778551 0.29452000 0.3318797
## 521 0.0040203105 -0.19604510 0.5769960
## 214 0.0041377325 0.07886582 0.5769960
## 622 0.0049707973 -0.39346926 0.5769960
## 139 0.0052507218 0.35182242 0.5769960
## 259 0.0061508055 -0.21960433 0.5907369
## 190 0.0065703798 0.28202466 0.5907369
## 533 0.0077505891 0.29603867 0.6097574
## 980 0.0092480903 -0.37580533 0.6097574
## 981 0.0092480903 -0.37580533 0.6097574
## 982 0.0092480903 -0.37580533 0.6097574mitch_plots(res,outfile="mitch_plots.pdf")## png
## 2unlink("mitch_report.html")
#mitch_report(res,outfile="mitch_report.html")CvL$score <- sign(CvL$meth.diff)/-log(CvL$pvalue)
CvL[is.na(CvL$score),"score"] <- 0
pp <- CvL[,c("gene_id","score")]
pp <- subset(pp, !duplicated(pp$gene_id))
rownames(pp) <- pp$gene_id
pp$gene_id=NULL
head(pp)## score
## ENSPREG00000014846 -0.009164084
## ENSPREG00000003617 0.010839060
## ENSPREG00000010182 -0.010866299
## ENSPREG00000012722 -0.011067234
## ENSPREG00000009393 -0.011118346
## ENSPREG00000008406 0.014135853res <- mitch_calc(x=pp,genesets=mysets,resrows=50)## Note: When prioritising by significance (ie: small
## p-values), large effect sizes might be missed.head(res$enrichment_result,15)## set setSize
## 852 GO:0033179 proton-transporting V-type ATPase, V0 domain 11
## 475 GO:0016042 lipid catabolic process 63
## 105 GO:0007218 neuropeptide signaling pathway 33
## 585 GO:0005184 neuropeptide hormone activity 14
## 885 GO:0005901 caveola 20
## 942 GO:0030516 regulation of axon extension 10
## 406 GO:0006417 regulation of translation 40
## 597 GO:0060027 convergent extension involved in gastrulation 39
## 342 GO:0000902 cell morphogenesis 18
## 928 GO:0043005 neuron projection 10
## 658 GO:0030027 lamellipodium 42
## 236 GO:0019221 cytokine-mediated signaling pathway 29
## 260 GO:0030488 tRNA methylation 15
## 551 GO:0007519 skeletal muscle tissue development 39
## 515 GO:0006979 response to oxidative stress 23
## pANOVA s.dist p.adjustANOVA
## 852 0.0009029654 0.5778944 0.8810044
## 475 0.0023418376 0.2216631 0.8810044
## 105 0.0026751147 -0.3020093 0.8810044
## 585 0.0053745076 -0.4296577 0.9182117
## 885 0.0058290972 0.3561129 0.9182117
## 942 0.0065030817 -0.4969357 0.9182117
## 406 0.0065055484 -0.2486294 0.9182117
## 597 0.0090395605 0.2415591 0.9568378
## 342 0.0095375465 0.3528884 0.9568378
## 928 0.0135377050 0.4509295 0.9568378
## 658 0.0135392364 -0.2201908 0.9568378
## 236 0.0143828692 -0.2625790 0.9568378
## 260 0.0164616065 0.3576710 0.9568378
## 551 0.0170373301 0.2207744 0.9568378
## 515 0.0172476001 -0.2868359 0.9568378mitch_plots(res,outfile="mitch_plots.pdf")## png
## 2unlink("mitch_report.html")
#mitch_report(res,outfile="mitch_report.html")GvL$score <- sign(GvL$meth.diff)/-log(GvL$pvalue)
GvL[is.na(GvL$score),"score"] <- 0
pp <- GvL[,c("gene_id","score")]
pp <- subset(pp, !duplicated(pp$gene_id))
rownames(pp) <- pp$gene_id
pp$gene_id=NULL
head(pp)## score
## ENSPREG00000021468 -0.003099342
## ENSPREG00000021490 -0.003099342
## ENSPREG00000012722 -0.011054796
## ENSPREG00000009393 -0.012559963
## ENSPREG00000002699 0.012747733
## ENSPREG00000004582 0.013337674res <- mitch_calc(x=pp,genesets=mysets,resrows=50)## Note: When prioritising by significance (ie: small
## p-values), large effect sizes might be missed.head(res$enrichment_result,15)## set
## 621 GO:0050661 NADP binding
## 882 GO:0021522 spinal cord motor neuron differentiation
## 115 GO:0002224 toll-like receptor signaling pathway
## 217 GO:0005096 GTPase activator activity
## 412 GO:0007420 brain development
## 732 GO:0032580 Golgi cisterna membrane
## 225 GO:0042742 defense response to bacterium
## 29 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
## 304 GO:0006281 DNA repair
## 68 GO:0007264 small GTPase mediated signal transduction
## 934 GO:0015035 protein disulfide oxidoreductase activity
## 218 GO:0043547 positive regulation of GTPase activity
## 272 GO:0061630 ubiquitin protein ligase activity
## 188 GO:0007049 cell cycle
## 369 GO:0005164 tumor necrosis factor receptor binding
## setSize pANOVA s.dist p.adjustANOVA
## 621 22 0.0007207875 0.4164207 0.5475375
## 882 16 0.0014333236 0.4602702 0.5475375
## 115 21 0.0024467860 0.3818918 0.5475375
## 217 146 0.0024865080 -0.1450227 0.5475375
## 412 109 0.0027653407 -0.1659072 0.5475375
## 732 30 0.0051948564 -0.2947819 0.7938422
## 225 35 0.0065184078 0.2657010 0.7938422
## 29 13 0.0065513932 -0.4354796 0.7938422
## 304 132 0.0080262148 0.1336215 0.7938422
## 68 93 0.0082969657 -0.1583746 0.7938422
## 934 16 0.0095738361 -0.3740885 0.7938422
## 218 149 0.0097512943 -0.1226650 0.7938422
## 272 78 0.0104241901 -0.1677459 0.7938422
## 188 137 0.0127542436 0.1232397 0.9014014
## 369 21 0.0141747141 0.3091710 0.9014014mitch_plots(res,outfile="mitch_plots.pdf")## png
## 2unlink("mitch_report.html")
#mitch_report(res,outfile="mitch_report.html")library(reshape2)
mysetsdf <- melt(mysets)
head(mysetsdf)## value L1
## 1 ENSPREG00000000007 GO:0008137 NADH dehydrogenase (ubiquinone) activity
## 2 ENSPREG00000000011 GO:0008137 NADH dehydrogenase (ubiquinone) activity
## 3 ENSPREG00000000026 GO:0008137 NADH dehydrogenase (ubiquinone) activity
## 4 ENSPREG00000000028 GO:0008137 NADH dehydrogenase (ubiquinone) activity
## 5 ENSPREG00000000029 GO:0008137 NADH dehydrogenase (ubiquinone) activity
## 6 ENSPREG00000000033 GO:0008137 NADH dehydrogenase (ubiquinone) activitymysetsdf <-mysetsdf[,c(2,1)]
head(mysetsdf)## L1 value
## 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity ENSPREG00000000007
## 2 GO:0008137 NADH dehydrogenase (ubiquinone) activity ENSPREG00000000011
## 3 GO:0008137 NADH dehydrogenase (ubiquinone) activity ENSPREG00000000026
## 4 GO:0008137 NADH dehydrogenase (ubiquinone) activity ENSPREG00000000028
## 5 GO:0008137 NADH dehydrogenase (ubiquinone) activity ENSPREG00000000029
## 6 GO:0008137 NADH dehydrogenase (ubiquinone) activity ENSPREG00000000033CvG_up <- subset(CvG,meth.diff>0&qvalue<0.05)
CvG_up <- unique(CvG_up$gene_id)
str(CvG_up)## chr [1:2812] "ENSPREG00000021468" "ENSPREG00000021490" ...CvG_dn <- subset(CvG,meth.diff<0&qvalue<0.05)
CvG_dn <- unique(CvG_dn$gene_id)
str(CvG_dn)## chr [1:5081] "ENSPREG00000004582" "ENSPREG00000004594" ...CvG_bg <- unique(CvG$gene_id)
str(CvG_bg)## chr [1:21591] "ENSPREG00000021468" "ENSPREG00000021490" ...c_up <- enricher(gene = CvG_up, universe = CvG_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_up,15)## ID
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GO:0007409 axonogenesis GO:0007409 axonogenesis
## GO:0030334 regulation of cell migration GO:0030334 regulation of cell migration
## GO:0014032 neural crest cell development GO:0014032 neural crest cell development
## GO:0005249 voltage-gated potassium channel activity GO:0005249 voltage-gated potassium channel activity
## GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity
## GO:0030916 otic vesicle formation GO:0030916 otic vesicle formation
## GO:0045176 apical protein localization GO:0045176 apical protein localization
## GO:1905606 regulation of presynapse assembly GO:1905606 regulation of presynapse assembly
## GO:0003682 chromatin binding GO:0003682 chromatin binding
## GO:0006836 neurotransmitter transport GO:0006836 neurotransmitter transport
## GO:0005096 GTPase activator activity GO:0005096 GTPase activator activity
## GO:0051260 protein homooligomerization GO:0051260 protein homooligomerization
## GO:0030318 melanocyte differentiation GO:0030318 melanocyte differentiation
## Description
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GO:0007409 axonogenesis GO:0007409 axonogenesis
## GO:0030334 regulation of cell migration GO:0030334 regulation of cell migration
## GO:0014032 neural crest cell development GO:0014032 neural crest cell development
## GO:0005249 voltage-gated potassium channel activity GO:0005249 voltage-gated potassium channel activity
## GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity
## GO:0030916 otic vesicle formation GO:0030916 otic vesicle formation
## GO:0045176 apical protein localization GO:0045176 apical protein localization
## GO:1905606 regulation of presynapse assembly GO:1905606 regulation of presynapse assembly
## GO:0003682 chromatin binding GO:0003682 chromatin binding
## GO:0006836 neurotransmitter transport GO:0006836 neurotransmitter transport
## GO:0005096 GTPase activator activity GO:0005096 GTPase activator activity
## GO:0051260 protein homooligomerization GO:0051260 protein homooligomerization
## GO:0030318 melanocyte differentiation GO:0030318 melanocyte differentiation
## GeneRatio
## GO:0030155 regulation of cell adhesion 5/2380
## GO:0046716 muscle cell cellular homeostasis 5/2380
## GO:0007409 axonogenesis 12/2380
## GO:0030334 regulation of cell migration 6/2380
## GO:0014032 neural crest cell development 9/2380
## GO:0005249 voltage-gated potassium channel activity 18/2380
## GO:0004714 transmembrane receptor protein tyrosine kinase activity 22/2380
## GO:0030916 otic vesicle formation 4/2380
## GO:0045176 apical protein localization 4/2380
## GO:1905606 regulation of presynapse assembly 4/2380
## GO:0003682 chromatin binding 12/2380
## GO:0006836 neurotransmitter transport 7/2380
## GO:0005096 GTPase activator activity 30/2380
## GO:0051260 protein homooligomerization 15/2380
## GO:0030318 melanocyte differentiation 9/2380
## BgRatio
## GO:0030155 regulation of cell adhesion 7/18074
## GO:0046716 muscle cell cellular homeostasis 7/18074
## GO:0007409 axonogenesis 39/18074
## GO:0030334 regulation of cell migration 13/18074
## GO:0014032 neural crest cell development 27/18074
## GO:0005249 voltage-gated potassium channel activity 74/18074
## GO:0004714 transmembrane receptor protein tyrosine kinase activity 97/18074
## GO:0030916 otic vesicle formation 7/18074
## GO:0045176 apical protein localization 7/18074
## GO:1905606 regulation of presynapse assembly 7/18074
## GO:0003682 chromatin binding 43/18074
## GO:0006836 neurotransmitter transport 19/18074
## GO:0005096 GTPase activator activity 146/18074
## GO:0051260 protein homooligomerization 60/18074
## GO:0030318 melanocyte differentiation 29/18074
## pvalue
## GO:0030155 regulation of cell adhesion 0.000657154
## GO:0046716 muscle cell cellular homeostasis 0.000657154
## GO:0007409 axonogenesis 0.003329435
## GO:0030334 regulation of cell migration 0.003882918
## GO:0014032 neural crest cell development 0.005904426
## GO:0005249 voltage-gated potassium channel activity 0.006513720
## GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.006881631
## GO:0030916 otic vesicle formation 0.007536119
## GO:0045176 apical protein localization 0.007536119
## GO:1905606 regulation of presynapse assembly 0.007536119
## GO:0003682 chromatin binding 0.007917874
## GO:0006836 neurotransmitter transport 0.008081303
## GO:0005096 GTPase activator activity 0.008257486
## GO:0051260 protein homooligomerization 0.009559968
## GO:0030318 melanocyte differentiation 0.009888595
## p.adjust
## GO:0030155 regulation of cell adhesion 0.4669079
## GO:0046716 muscle cell cellular homeostasis 0.4669079
## GO:0007409 axonogenesis 0.7950773
## GO:0030334 regulation of cell migration 0.7950773
## GO:0014032 neural crest cell development 0.7950773
## GO:0005249 voltage-gated potassium channel activity 0.7950773
## GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.7950773
## GO:0030916 otic vesicle formation 0.7950773
## GO:0045176 apical protein localization 0.7950773
## GO:1905606 regulation of presynapse assembly 0.7950773
## GO:0003682 chromatin binding 0.7950773
## GO:0006836 neurotransmitter transport 0.7950773
## GO:0005096 GTPase activator activity 0.7950773
## GO:0051260 protein homooligomerization 0.7950773
## GO:0030318 melanocyte differentiation 0.7950773
## qvalue
## GO:0030155 regulation of cell adhesion 0.4669079
## GO:0046716 muscle cell cellular homeostasis 0.4669079
## GO:0007409 axonogenesis 0.7950773
## GO:0030334 regulation of cell migration 0.7950773
## GO:0014032 neural crest cell development 0.7950773
## GO:0005249 voltage-gated potassium channel activity 0.7950773
## GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.7950773
## GO:0030916 otic vesicle formation 0.7950773
## GO:0045176 apical protein localization 0.7950773
## GO:1905606 regulation of presynapse assembly 0.7950773
## GO:0003682 chromatin binding 0.7950773
## GO:0006836 neurotransmitter transport 0.7950773
## GO:0005096 GTPase activator activity 0.7950773
## GO:0051260 protein homooligomerization 0.7950773
## GO:0030318 melanocyte differentiation 0.7950773
## geneID
## GO:0030155 regulation of cell adhesion ENSPREG00000020191/ENSPREG00000010044/ENSPREG00000011543/ENSPREG00000019336/ENSPREG00000006389
## GO:0046716 muscle cell cellular homeostasis ENSPREG00000009411/ENSPREG00000019794/ENSPREG00000020904/ENSPREG00000012706/ENSPREG00000002855
## GO:0007409 axonogenesis ENSPREG00000003714/ENSPREG00000009462/ENSPREG00000017257/ENSPREG00000019606/ENSPREG00000008887/ENSPREG00000013382/ENSPREG00000019248/ENSPREG00000007334/ENSPREG00000004376/ENSPREG00000000399/ENSPREG00000019454/ENSPREG00000019208
## GO:0030334 regulation of cell migration ENSPREG00000020191/ENSPREG00000010044/ENSPREG00000011543/ENSPREG00000019336/ENSPREG00000021543/ENSPREG00000010633
## GO:0014032 neural crest cell development ENSPREG00000000111/ENSPREG00000020900/ENSPREG00000001888/ENSPREG00000018936/ENSPREG00000020875/ENSPREG00000018525/ENSPREG00000019652/ENSPREG00000016745/ENSPREG00000004044
## GO:0005249 voltage-gated potassium channel activity ENSPREG00000021731/ENSPREG00000016360/ENSPREG00000000873/ENSPREG00000015244/ENSPREG00000019994/ENSPREG00000018137/ENSPREG00000015851/ENSPREG00000017898/ENSPREG00000021031/ENSPREG00000001739/ENSPREG00000013809/ENSPREG00000020923/ENSPREG00000019713/ENSPREG00000019707/ENSPREG00000012123/ENSPREG00000018859/ENSPREG00000005859/ENSPREG00000021682
## GO:0004714 transmembrane receptor protein tyrosine kinase activity ENSPREG00000008541/ENSPREG00000009500/ENSPREG00000018326/ENSPREG00000010744/ENSPREG00000011543/ENSPREG00000006673/ENSPREG00000020900/ENSPREG00000019556/ENSPREG00000001707/ENSPREG00000005719/ENSPREG00000019336/ENSPREG00000009040/ENSPREG00000018109/ENSPREG00000003825/ENSPREG00000001857/ENSPREG00000019671/ENSPREG00000008419/ENSPREG00000002914/ENSPREG00000004058/ENSPREG00000020673/ENSPREG00000009183/ENSPREG00000004587
## GO:0030916 otic vesicle formation ENSPREG00000002057/ENSPREG00000004689/ENSPREG00000001888/ENSPREG00000008334
## GO:0045176 apical protein localization ENSPREG00000018047/ENSPREG00000014551/ENSPREG00000013611/ENSPREG00000013331
## GO:1905606 regulation of presynapse assembly ENSPREG00000017257/ENSPREG00000008887/ENSPREG00000019248/ENSPREG00000019208
## GO:0003682 chromatin binding ENSPREG00000020416/ENSPREG00000016522/ENSPREG00000001380/ENSPREG00000007118/ENSPREG00000018256/ENSPREG00000007490/ENSPREG00000005028/ENSPREG00000015840/ENSPREG00000019882/ENSPREG00000002725/ENSPREG00000012260/ENSPREG00000019101
## GO:0006836 neurotransmitter transport ENSPREG00000017749/ENSPREG00000001650/ENSPREG00000018029/ENSPREG00000020142/ENSPREG00000003012/ENSPREG00000008121/ENSPREG00000000273
## GO:0005096 GTPase activator activity ENSPREG00000017857/ENSPREG00000002721/ENSPREG00000009884/ENSPREG00000004344/ENSPREG00000008165/ENSPREG00000009970/ENSPREG00000021572/ENSPREG00000020745/ENSPREG00000010160/ENSPREG00000008818/ENSPREG00000021455/ENSPREG00000005604/ENSPREG00000000815/ENSPREG00000011527/ENSPREG00000003515/ENSPREG00000002871/ENSPREG00000016181/ENSPREG00000010858/ENSPREG00000021002/ENSPREG00000001038/ENSPREG00000005055/ENSPREG00000020238/ENSPREG00000003783/ENSPREG00000006835/ENSPREG00000019122/ENSPREG00000014913/ENSPREG00000015619/ENSPREG00000006302/ENSPREG00000009077/ENSPREG00000003620
## GO:0051260 protein homooligomerization ENSPREG00000021731/ENSPREG00000015244/ENSPREG00000019994/ENSPREG00000011284/ENSPREG00000021031/ENSPREG00000013809/ENSPREG00000020923/ENSPREG00000019713/ENSPREG00000004636/ENSPREG00000019707/ENSPREG00000022480/ENSPREG00000015801/ENSPREG00000018859/ENSPREG00000016649/ENSPREG00000021682
## GO:0030318 melanocyte differentiation ENSPREG00000009893/ENSPREG00000002057/ENSPREG00000010109/ENSPREG00000020900/ENSPREG00000002975/ENSPREG00000005265/ENSPREG00000019772/ENSPREG00000019652/ENSPREG00000016745
## Count
## GO:0030155 regulation of cell adhesion 5
## GO:0046716 muscle cell cellular homeostasis 5
## GO:0007409 axonogenesis 12
## GO:0030334 regulation of cell migration 6
## GO:0014032 neural crest cell development 9
## GO:0005249 voltage-gated potassium channel activity 18
## GO:0004714 transmembrane receptor protein tyrosine kinase activity 22
## GO:0030916 otic vesicle formation 4
## GO:0045176 apical protein localization 4
## GO:1905606 regulation of presynapse assembly 4
## GO:0003682 chromatin binding 12
## GO:0006836 neurotransmitter transport 7
## GO:0005096 GTPase activator activity 30
## GO:0051260 protein homooligomerization 15
## GO:0030318 melanocyte differentiation 9c_dn <- enricher(gene = CvG_dn, universe = CvG_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_dn,15)## ID
## GO:0060294 cilium movement involved in cell motility GO:0060294 cilium movement involved in cell motility
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0030837 negative regulation of actin filament polymerization GO:0030837 negative regulation of actin filament polymerization
## GO:0006596 polyamine biosynthetic process GO:0006596 polyamine biosynthetic process
## GO:0030111 regulation of Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0030522 intracellular receptor signaling pathway GO:0030522 intracellular receptor signaling pathway
## GO:0003094 glomerular filtration GO:0003094 glomerular filtration
## GO:0009887 animal organ morphogenesis GO:0009887 animal organ morphogenesis
## GO:0045296 cadherin binding GO:0045296 cadherin binding
## GO:0045104 intermediate filament cytoskeleton organization GO:0045104 intermediate filament cytoskeleton organization
## GO:0048484 enteric nervous system development GO:0048484 enteric nervous system development
## GO:0021549 cerebellum development GO:0021549 cerebellum development
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GO:0032422 purine-rich negative regulatory element binding GO:0032422 purine-rich negative regulatory element binding
## Description
## GO:0060294 cilium movement involved in cell motility GO:0060294 cilium movement involved in cell motility
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0030837 negative regulation of actin filament polymerization GO:0030837 negative regulation of actin filament polymerization
## GO:0006596 polyamine biosynthetic process GO:0006596 polyamine biosynthetic process
## GO:0030111 regulation of Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0030522 intracellular receptor signaling pathway GO:0030522 intracellular receptor signaling pathway
## GO:0003094 glomerular filtration GO:0003094 glomerular filtration
## GO:0009887 animal organ morphogenesis GO:0009887 animal organ morphogenesis
## GO:0045296 cadherin binding GO:0045296 cadherin binding
## GO:0045104 intermediate filament cytoskeleton organization GO:0045104 intermediate filament cytoskeleton organization
## GO:0048484 enteric nervous system development GO:0048484 enteric nervous system development
## GO:0021549 cerebellum development GO:0021549 cerebellum development
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GO:0032422 purine-rich negative regulatory element binding GO:0032422 purine-rich negative regulatory element binding
## GeneRatio
## GO:0060294 cilium movement involved in cell motility 6/4253
## GO:0007275 multicellular organism development 142/4253
## GO:0030837 negative regulation of actin filament polymerization 6/4253
## GO:0006596 polyamine biosynthetic process 5/4253
## GO:0030111 regulation of Wnt signaling pathway 5/4253
## GO:0005515 protein binding 858/4253
## GO:0030522 intracellular receptor signaling pathway 13/4253
## GO:0003094 glomerular filtration 7/4253
## GO:0009887 animal organ morphogenesis 8/4253
## GO:0045296 cadherin binding 6/4253
## GO:0045104 intermediate filament cytoskeleton organization 9/4253
## GO:0048484 enteric nervous system development 10/4253
## GO:0021549 cerebellum development 8/4253
## GO:0006384 transcription initiation from RNA polymerase III promoter 4/4253
## GO:0032422 purine-rich negative regulatory element binding 4/4253
## BgRatio
## GO:0060294 cilium movement involved in cell motility 7/18074
## GO:0007275 multicellular organism development 480/18074
## GO:0030837 negative regulation of actin filament polymerization 8/18074
## GO:0006596 polyamine biosynthetic process 6/18074
## GO:0030111 regulation of Wnt signaling pathway 6/18074
## GO:0005515 protein binding 3393/18074
## GO:0030522 intracellular receptor signaling pathway 27/18074
## GO:0003094 glomerular filtration 11/18074
## GO:0009887 animal organ morphogenesis 14/18074
## GO:0045296 cadherin binding 9/18074
## GO:0045104 intermediate filament cytoskeleton organization 17/18074
## GO:0048484 enteric nervous system development 20/18074
## GO:0021549 cerebellum development 15/18074
## GO:0006384 transcription initiation from RNA polymerase III promoter 5/18074
## GO:0032422 purine-rich negative regulatory element binding 5/18074
## pvalue
## GO:0060294 cilium movement involved in cell motility 0.0009463683
## GO:0007275 multicellular organism development 0.0011675622
## GO:0030837 negative regulation of actin filament polymerization 0.0030267614
## GO:0006596 polyamine biosynthetic process 0.0034743789
## GO:0030111 regulation of Wnt signaling pathway 0.0034743789
## GO:0005515 protein binding 0.0041551998
## GO:0030522 intracellular receptor signaling pathway 0.0044655248
## GO:0003094 glomerular filtration 0.0052632219
## GO:0009887 animal organ morphogenesis 0.0069807621
## GO:0045296 cadherin binding 0.0072703056
## GO:0045104 intermediate filament cytoskeleton organization 0.0081621634
## GO:0048484 enteric nervous system development 0.0088975714
## GO:0021549 cerebellum development 0.0119020100
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.0124325837
## GO:0032422 purine-rich negative regulatory element binding 0.0124325837
## p.adjust
## GO:0060294 cilium movement involved in cell motility 0.9614875
## GO:0007275 multicellular organism development 0.9614875
## GO:0030837 negative regulation of actin filament polymerization 0.9848883
## GO:0006596 polyamine biosynthetic process 0.9848883
## GO:0030111 regulation of Wnt signaling pathway 0.9848883
## GO:0005515 protein binding 0.9848883
## GO:0030522 intracellular receptor signaling pathway 0.9848883
## GO:0003094 glomerular filtration 0.9848883
## GO:0009887 animal organ morphogenesis 0.9848883
## GO:0045296 cadherin binding 0.9848883
## GO:0045104 intermediate filament cytoskeleton organization 0.9848883
## GO:0048484 enteric nervous system development 0.9848883
## GO:0021549 cerebellum development 0.9848883
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.9848883
## GO:0032422 purine-rich negative regulatory element binding 0.9848883
## qvalue
## GO:0060294 cilium movement involved in cell motility 0.9614875
## GO:0007275 multicellular organism development 0.9614875
## GO:0030837 negative regulation of actin filament polymerization 0.9848883
## GO:0006596 polyamine biosynthetic process 0.9848883
## GO:0030111 regulation of Wnt signaling pathway 0.9848883
## GO:0005515 protein binding 0.9848883
## GO:0030522 intracellular receptor signaling pathway 0.9848883
## GO:0003094 glomerular filtration 0.9848883
## GO:0009887 animal organ morphogenesis 0.9848883
## GO:0045296 cadherin binding 0.9848883
## GO:0045104 intermediate filament cytoskeleton organization 0.9848883
## GO:0048484 enteric nervous system development 0.9848883
## GO:0021549 cerebellum development 0.9848883
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.9848883
## GO:0032422 purine-rich negative regulatory element binding 0.9848883
## geneID
## GO:0060294 cilium movement involved in cell motility ENSPREG00000009719/ENSPREG00000009761/ENSPREG00000012200/ENSPREG00000009128/ENSPREG00000020731/ENSPREG00000011030
## GO:0007275 multicellular organism development ENSPREG00000000612/ENSPREG00000000557/ENSPREG00000021322/ENSPREG00000021021/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000020332/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000018360/ENSPREG00000013766/ENSPREG00000003001/ENSPREG00000009481/ENSPREG00000021725/ENSPREG00000016378/ENSPREG00000010783/ENSPREG00000003088/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000004667/ENSPREG00000009349/ENSPREG00000014773/ENSPREG00000000563/ENSPREG00000010797/ENSPREG00000001340/ENSPREG00000013812/ENSPREG00000017475/ENSPREG00000005101/ENSPREG00000000133/ENSPREG00000010790/ENSPREG00000008022/ENSPREG00000005343/ENSPREG00000011756/ENSPREG00000006760/ENSPREG00000014079/ENSPREG00000002673/ENSPREG00000001346/ENSPREG00000012541/ENSPREG00000011913/ENSPREG00000007669/ENSPREG00000015465/ENSPREG00000013058/ENSPREG00000019287/ENSPREG00000009731/ENSPREG00000013353/ENSPREG00000000532/ENSPREG00000021227/ENSPREG00000006758/ENSPREG00000006190/ENSPREG00000007900/ENSPREG00000004689/ENSPREG00000011561/ENSPREG00000012697/ENSPREG00000021274/ENSPREG00000020658/ENSPREG00000006606/ENSPREG00000015499/ENSPREG00000018135/ENSPREG00000001072/ENSPREG00000008300/ENSPREG00000018299/ENSPREG00000013601/ENSPREG00000008696/ENSPREG00000018652/ENSPREG00000011038/ENSPREG00000020206/ENSPREG00000006787/ENSPREG00000000683/ENSPREG00000010793/ENSPREG00000017901/ENSPREG00000006772/ENSPREG00000009363/ENSPREG00000015450/ENSPREG00000002053/ENSPREG00000013209/ENSPREG00000023206/ENSPREG00000001810/ENSPREG00000001397/ENSPREG00000009356/ENSPREG00000004970/ENSPREG00000017077/ENSPREG00000005380/ENSPREG00000006819/ENSPREG00000011441/ENSPREG00000001804/ENSPREG00000021949/ENSPREG00000006631/ENSPREG00000008297/ENSPREG00000019085/ENSPREG00000020667/ENSPREG00000020203/ENSPREG00000002795/ENSPREG00000017001/ENSPREG00000001918/ENSPREG00000013048/ENSPREG00000020340/ENSPREG00000000163/ENSPREG00000003379/ENSPREG00000006929/ENSPREG00000021144/ENSPREG00000011620/ENSPREG00000008016/ENSPREG00000012105/ENSPREG00000015326/ENSPREG00000008325/ENSPREG00000011721/ENSPREG00000020178/ENSPREG00000011089/ENSPREG00000013684/ENSPREG00000014000/ENSPREG00000002598/ENSPREG00000023212/ENSPREG00000020538/ENSPREG00000001265/ENSPREG00000022538/ENSPREG00000015189/ENSPREG00000015884/ENSPREG00000008801/ENSPREG00000013636/ENSPREG00000003992/ENSPREG00000006101/ENSPREG00000005482/ENSPREG00000003325/ENSPREG00000014120/ENSPREG00000002679/ENSPREG00000019531/ENSPREG00000006981/ENSPREG00000021597/ENSPREG00000004436/ENSPREG00000019962/ENSPREG00000018009/ENSPREG00000007418/ENSPREG00000017669/ENSPREG00000014038/ENSPREG00000020848/ENSPREG00000003491/ENSPREG00000009171/ENSPREG00000023233/ENSPREG00000001369/ENSPREG00000006716/ENSPREG00000010959/ENSPREG00000002135
## GO:0030837 negative regulation of actin filament polymerization ENSPREG00000004859/ENSPREG00000009872/ENSPREG00000002396/ENSPREG00000022136/ENSPREG00000006482/ENSPREG00000005608
## GO:0006596 polyamine biosynthetic process ENSPREG00000004500/ENSPREG00000020488/ENSPREG00000007004/ENSPREG00000016481/ENSPREG00000019739
## GO:0030111 regulation of Wnt signaling pathway ENSPREG00000006261/ENSPREG00000021155/ENSPREG00000003447/ENSPREG00000019287/ENSPREG00000011016
## GO:0005515 protein binding ENSPREG00000004594/ENSPREG00000001239/ENSPREG00000002366/ENSPREG00000010979/ENSPREG00000005998/ENSPREG00000021322/ENSPREG00000015181/ENSPREG00000016753/ENSPREG00000019833/ENSPREG00000015829/ENSPREG00000007226/ENSPREG00000015671/ENSPREG00000013014/ENSPREG00000021438/ENSPREG00000015822/ENSPREG00000012815/ENSPREG00000015471/ENSPREG00000009801/ENSPREG00000014283/ENSPREG00000005618/ENSPREG00000005211/ENSPREG00000018881/ENSPREG00000022767/ENSPREG00000000629/ENSPREG00000021291/ENSPREG00000019151/ENSPREG00000012218/ENSPREG00000015447/ENSPREG00000019390/ENSPREG00000019594/ENSPREG00000010172/ENSPREG00000002074/ENSPREG00000012104/ENSPREG00000007271/ENSPREG00000009984/ENSPREG00000014822/ENSPREG00000006840/ENSPREG00000011064/ENSPREG00000017582/ENSPREG00000003556/ENSPREG00000010201/ENSPREG00000010951/ENSPREG00000008155/ENSPREG00000022366/ENSPREG00000008367/ENSPREG00000018284/ENSPREG00000003728/ENSPREG00000000414/ENSPREG00000018360/ENSPREG00000007157/ENSPREG00000018430/ENSPREG00000009378/ENSPREG00000005463/ENSPREG00000003121/ENSPREG00000008410/ENSPREG00000002585/ENSPREG00000013315/ENSPREG00000016523/ENSPREG00000016312/ENSPREG00000023076/ENSPREG00000005185/ENSPREG00000017977/ENSPREG00000001224/ENSPREG00000002370/ENSPREG00000009493/ENSPREG00000018231/ENSPREG00000001908/ENSPREG00000021275/ENSPREG00000006028/ENSPREG00000010997/ENSPREG00000012543/ENSPREG00000004150/ENSPREG00000005590/ENSPREG00000014503/ENSPREG00000011179/ENSPREG00000009775/ENSPREG00000019675/ENSPREG00000012528/ENSPREG00000012550/ENSPREG00000016789/ENSPREG00000010051/ENSPREG00000012500/ENSPREG00000007903/ENSPREG00000018352/ENSPREG00000014206/ENSPREG00000019165/ENSPREG00000011314/ENSPREG00000022512/ENSPREG00000017408/ENSPREG00000015288/ENSPREG00000020231/ENSPREG00000006834/ENSPREG00000020595/ENSPREG00000008274/ENSPREG00000014100/ENSPREG00000019952/ENSPREG00000018426/ENSPREG00000015859/ENSPREG00000009791/ENSPREG00000013129/ENSPREG00000021927/ENSPREG00000004300/ENSPREG00000005315/ENSPREG00000015428/ENSPREG00000014698/ENSPREG00000003829/ENSPREG00000020189/ENSPREG00000021917/ENSPREG00000021333/ENSPREG00000007778/ENSPREG00000006590/ENSPREG00000011954/ENSPREG00000002257/ENSPREG00000017655/ENSPREG00000015245/ENSPREG00000006779/ENSPREG00000001563/ENSPREG00000009666/ENSPREG00000014141/ENSPREG00000009745/ENSPREG00000018698/ENSPREG00000021025/ENSPREG00000018707/ENSPREG00000019661/ENSPREG00000008917/ENSPREG00000017204/ENSPREG00000014773/ENSPREG00000010832/ENSPREG00000019665/ENSPREG00000022222/ENSPREG00000023130/ENSPREG00000012699/ENSPREG00000022933/ENSPREG00000011541/ENSPREG00000003161/ENSPREG00000017709/ENSPREG00000022413/ENSPREG00000009677/ENSPREG00000011082/ENSPREG00000002029/ENSPREG00000007340/ENSPREG00000003604/ENSPREG00000009354/ENSPREG00000007360/ENSPREG00000015236/ENSPREG00000015301/ENSPREG00000002278/ENSPREG00000008285/ENSPREG00000019048/ENSPREG00000011222/ENSPREG00000009618/ENSPREG00000006244/ENSPREG00000002124/ENSPREG00000001690/ENSPREG00000009929/ENSPREG00000017121/ENSPREG00000011139/ENSPREG00000009610/ENSPREG00000011284/ENSPREG00000004984/ENSPREG00000014772/ENSPREG00000016993/ENSPREG00000009607/ENSPREG00000022386/ENSPREG00000020661/ENSPREG00000019970/ENSPREG00000012330/ENSPREG00000002327/ENSPREG00000010790/ENSPREG00000007848/ENSPREG00000015114/ENSPREG00000022836/ENSPREG00000011322/ENSPREG00000005173/ENSPREG00000023048/ENSPREG00000004018/ENSPREG00000008798/ENSPREG00000009248/ENSPREG00000020926/ENSPREG00000015389/ENSPREG00000011339/ENSPREG00000005423/ENSPREG00000008676/ENSPREG00000009089/ENSPREG00000020147/ENSPREG00000013491/ENSPREG00000000778/ENSPREG00000021689/ENSPREG00000002362/ENSPREG00000016425/ENSPREG00000013631/ENSPREG00000002967/ENSPREG00000015338/ENSPREG00000012757/ENSPREG00000019297/ENSPREG00000017751/ENSPREG00000008436/ENSPREG00000018540/ENSPREG00000015059/ENSPREG00000020763/ENSPREG00000016489/ENSPREG00000004461/ENSPREG00000021213/ENSPREG00000013118/ENSPREG00000020818/ENSPREG00000020410/ENSPREG00000005041/ENSPREG00000004459/ENSPREG00000009749/ENSPREG00000004632/ENSPREG00000013653/ENSPREG00000022336/ENSPREG00000021256/ENSPREG00000006668/ENSPREG00000014079/ENSPREG00000012251/ENSPREG00000002380/ENSPREG00000022393/ENSPREG00000016937/ENSPREG00000022932/ENSPREG00000014506/ENSPREG00000023226/ENSPREG00000015582/ENSPREG00000015155/ENSPREG00000005687/ENSPREG00000021150/ENSPREG00000013078/ENSPREG00000021744/ENSPREG00000021425/ENSPREG00000001330/ENSPREG00000003561/ENSPREG00000014672/ENSPREG00000006193/ENSPREG00000015996/ENSPREG00000018823/ENSPREG00000015203/ENSPREG00000001419/ENSPREG00000007852/ENSPREG00000016307/ENSPREG00000004335/ENSPREG00000015073/ENSPREG00000008915/ENSPREG00000017113/ENSPREG00000017617/ENSPREG00000016765/ENSPREG00000002215/ENSPREG00000017458/ENSPREG00000015391/ENSPREG00000007082/ENSPREG00000022957/ENSPREG00000013256/ENSPREG00000004560/ENSPREG00000005237/ENSPREG00000010157/ENSPREG00000015467/ENSPREG00000000452/ENSPREG00000009307/ENSPREG00000010745/ENSPREG00000020974/ENSPREG00000001094/ENSPREG00000000134/ENSPREG00000022695/ENSPREG00000000631/ENSPREG00000013162/ENSPREG00000015440/ENSPREG00000013733/ENSPREG00000018410/ENSPREG00000008562/ENSPREG00000019686/ENSPREG00000018815/ENSPREG00000019319/ENSPREG00000014502/ENSPREG00000011769/ENSPREG00000003815/ENSPREG00000007865/ENSPREG00000019630/ENSPREG00000020820/ENSPREG00000011036/ENSPREG00000002792/ENSPREG00000021545/ENSPREG00000004565/ENSPREG00000016861/ENSPREG00000014461/ENSPREG00000019680/ENSPREG00000009338/ENSPREG00000011331/ENSPREG00000021455/ENSPREG00000001482/ENSPREG00000009910/ENSPREG00000006662/ENSPREG00000019123/ENSPREG00000020380/ENSPREG00000009084/ENSPREG00000018599/ENSPREG00000010817/ENSPREG00000016174/ENSPREG00000008778/ENSPREG00000006550/ENSPREG00000007309/ENSPREG00000019287/ENSPREG00000011796/ENSPREG00000022710/ENSPREG00000012408/ENSPREG00000022731/ENSPREG00000010850/ENSPREG00000010398/ENSPREG00000016215/ENSPREG00000009091/ENSPREG00000004263/ENSPREG00000011940/ENSPREG00000011348/ENSPREG00000009555/ENSPREG00000021321/ENSPREG00000022213/ENSPREG00000022300/ENSPREG00000011953/ENSPREG00000015146/ENSPREG00000004250/ENSPREG00000015770/ENSPREG00000000089/ENSPREG00000007793/ENSPREG00000014612/ENSPREG00000017070/ENSPREG00000012430/ENSPREG00000011736/ENSPREG00000016757/ENSPREG00000004302/ENSPREG00000006253/ENSPREG00000018775/ENSPREG00000004711/ENSPREG00000015928/ENSPREG00000007441/ENSPREG00000015672/ENSPREG00000000980/ENSPREG00000020658/ENSPREG00000017550/ENSPREG00000002962/ENSPREG00000015791/ENSPREG00000007423/ENSPREG00000022747/ENSPREG00000017873/ENSPREG00000022000/ENSPREG00000021215/ENSPREG00000015925/ENSPREG00000014992/ENSPREG00000010543/ENSPREG00000022344/ENSPREG00000005900/ENSPREG00000004312/ENSPREG00000004636/ENSPREG00000011567/ENSPREG00000014608/ENSPREG00000020504/ENSPREG00000016294/ENSPREG00000000279/ENSPREG00000011302/ENSPREG00000000588/ENSPREG00000023062/ENSPREG00000009905/ENSPREG00000010589/ENSPREG00000000819/ENSPREG00000013460/ENSPREG00000022805/ENSPREG00000018477/ENSPREG00000015157/ENSPREG00000015399/ENSPREG00000011946/ENSPREG00000007744/ENSPREG00000000727/ENSPREG00000008240/ENSPREG00000015151/ENSPREG00000006354/ENSPREG00000016104/ENSPREG00000021811/ENSPREG00000006611/ENSPREG00000019070/ENSPREG00000001286/ENSPREG00000013171/ENSPREG00000005457/ENSPREG00000020789/ENSPREG00000018185/ENSPREG00000006639/ENSPREG00000008273/ENSPREG00000002144/ENSPREG00000017657/ENSPREG00000000375/ENSPREG00000015074/ENSPREG00000017759/ENSPREG00000009970/ENSPREG00000018652/ENSPREG00000023123/ENSPREG00000019505/ENSPREG00000021825/ENSPREG00000022454/ENSPREG00000015376/ENSPREG00000006065/ENSPREG00000012466/ENSPREG00000019745/ENSPREG00000008141/ENSPREG00000006956/ENSPREG00000018891/ENSPREG00000010585/ENSPREG00000022420/ENSPREG00000015048/ENSPREG00000010793/ENSPREG00000008897/ENSPREG00000012394/ENSPREG00000013110/ENSPREG00000007468/ENSPREG00000020432/ENSPREG00000009350/ENSPREG00000009469/ENSPREG00000020953/ENSPREG00000011776/ENSPREG00000023083/ENSPREG00000001638/ENSPREG00000007496/ENSPREG00000003053/ENSPREG00000004576/ENSPREG00000022877/ENSPREG00000012365/ENSPREG00000009239/ENSPREG00000020099/ENSPREG00000010125/ENSPREG00000017699/ENSPREG00000017770/ENSPREG00000020271/ENSPREG00000009363/ENSPREG00000006781/ENSPREG00000001799/ENSPREG00000007013/ENSPREG00000018631/ENSPREG00000009747/ENSPREG00000010674/ENSPREG00000000954/ENSPREG00000009630/ENSPREG00000011358/ENSPREG00000013046/ENSPREG00000008293/ENSPREG00000018317/ENSPREG00000021856/ENSPREG00000023222/ENSPREG00000019808/ENSPREG00000002053/ENSPREG00000008737/ENSPREG00000020515/ENSPREG00000021756/ENSPREG00000017893/ENSPREG00000022808/ENSPREG00000011345/ENSPREG00000014809/ENSPREG00000023011/ENSPREG00000002071/ENSPREG00000022200/ENSPREG00000000189/ENSPREG00000001857/ENSPREG00000016460/ENSPREG00000004333/ENSPREG00000015012/ENSPREG00000000958/ENSPREG00000002971/ENSPREG00000005510/ENSPREG00000009016/ENSPREG00000005229/ENSPREG00000001810/ENSPREG00000004360/ENSPREG00000001928/ENSPREG00000015532/ENSPREG00000015956/ENSPREG00000003610/ENSPREG00000015772/ENSPREG00000003133/ENSPREG00000022590/ENSPREG00000016036/ENSPREG00000019283/ENSPREG00000008558/ENSPREG00000019901/ENSPREG00000014532/ENSPREG00000019676/ENSPREG00000006393/ENSPREG00000017910/ENSPREG00000000956/ENSPREG00000002771/ENSPREG00000007218/ENSPREG00000018764/ENSPREG00000019225/ENSPREG00000015724/ENSPREG00000016532/ENSPREG00000018531/ENSPREG00000008338/ENSPREG00000000802/ENSPREG00000016483/ENSPREG00000005608/ENSPREG00000009816/ENSPREG00000007703/ENSPREG00000001336/ENSPREG00000010965/ENSPREG00000003967/ENSPREG00000002203/ENSPREG00000011102/ENSPREG00000012767/ENSPREG00000002540/ENSPREG00000002294/ENSPREG00000008228/ENSPREG00000009412/ENSPREG00000014336/ENSPREG00000022687/ENSPREG00000014490/ENSPREG00000004105/ENSPREG00000009286/ENSPREG00000022708/ENSPREG00000000212/ENSPREG00000020451/ENSPREG00000004395/ENSPREG00000005893/ENSPREG00000013348/ENSPREG00000018525/ENSPREG00000010824/ENSPREG00000017488/ENSPREG00000019713/ENSPREG00000017711/ENSPREG00000008369/ENSPREG00000005291/ENSPREG00000000181/ENSPREG00000004867/ENSPREG00000003558/ENSPREG00000003960/ENSPREG00000003963/ENSPREG00000011365/ENSPREG00000017093/ENSPREG00000005588/ENSPREG00000020891/ENSPREG00000004187/ENSPREG00000009885/ENSPREG00000017242/ENSPREG00000011944/ENSPREG00000001029/ENSPREG00000015635/ENSPREG00000019049/ENSPREG00000001983/ENSPREG00000022596/ENSPREG00000007678/ENSPREG00000001587/ENSPREG00000020970/ENSPREG00000016663/ENSPREG00000022570/ENSPREG00000018609/ENSPREG00000010047/ENSPREG00000013539/ENSPREG00000006553/ENSPREG00000006571/ENSPREG00000000857/ENSPREG00000013538/ENSPREG00000009415/ENSPREG00000003345/ENSPREG00000014824/ENSPREG00000019273/ENSPREG00000020123/ENSPREG00000003003/ENSPREG00000016369/ENSPREG00000010318/ENSPREG00000007620/ENSPREG00000012361/ENSPREG00000009669/ENSPREG00000022278/ENSPREG00000000343/ENSPREG00000011854/ENSPREG00000006874/ENSPREG00000005336/ENSPREG00000000681/ENSPREG00000020399/ENSPREG00000001918/ENSPREG00000004391/ENSPREG00000014043/ENSPREG00000009173/ENSPREG00000010808/ENSPREG00000018582/ENSPREG00000016255/ENSPREG00000016311/ENSPREG00000003502/ENSPREG00000004149/ENSPREG00000009287/ENSPREG00000007092/ENSPREG00000008027/ENSPREG00000020583/ENSPREG00000012615/ENSPREG00000005420/ENSPREG00000012620/ENSPREG00000002204/ENSPREG00000016073/ENSPREG00000017741/ENSPREG00000015578/ENSPREG00000019855/ENSPREG00000009830/ENSPREG00000002891/ENSPREG00000008622/ENSPREG00000020711/ENSPREG00000003437/ENSPREG00000011931/ENSPREG00000016331/ENSPREG00000010742/ENSPREG00000016974/ENSPREG00000017839/ENSPREG00000006425/ENSPREG00000009071/ENSPREG00000015899/ENSPREG00000002675/ENSPREG00000018632/ENSPREG00000000162/ENSPREG00000013094/ENSPREG00000023195/ENSPREG00000013344/ENSPREG00000015988/ENSPREG00000007756/ENSPREG00000003820/ENSPREG00000007693/ENSPREG00000007039/ENSPREG00000020771/ENSPREG00000000704/ENSPREG00000022353/ENSPREG00000001415/ENSPREG00000003150/ENSPREG00000002932/ENSPREG00000019192/ENSPREG00000022447/ENSPREG00000000900/ENSPREG00000010928/ENSPREG00000010127/ENSPREG00000017613/ENSPREG00000005086/ENSPREG00000015764/ENSPREG00000005614/ENSPREG00000014790/ENSPREG00000006810/ENSPREG00000011027/ENSPREG00000001790/ENSPREG00000020450/ENSPREG00000022109/ENSPREG00000016362/ENSPREG00000014150/ENSPREG00000012388/ENSPREG00000006035/ENSPREG00000020906/ENSPREG00000003290/ENSPREG00000001968/ENSPREG00000018217/ENSPREG00000018400/ENSPREG00000019780/ENSPREG00000021727/ENSPREG00000007919/ENSPREG00000014668/ENSPREG00000020747/ENSPREG00000017525/ENSPREG00000010978/ENSPREG00000003630/ENSPREG00000001103/ENSPREG00000002749/ENSPREG00000020218/ENSPREG00000018831/ENSPREG00000012860/ENSPREG00000019002/ENSPREG00000015991/ENSPREG00000008157/ENSPREG00000018926/ENSPREG00000017641/ENSPREG00000016525/ENSPREG00000014823/ENSPREG00000010347/ENSPREG00000008550/ENSPREG00000020126/ENSPREG00000019095/ENSPREG00000009537/ENSPREG00000010460/ENSPREG00000000528/ENSPREG00000017575/ENSPREG00000002598/ENSPREG00000008024/ENSPREG00000002884/ENSPREG00000012276/ENSPREG00000003411/ENSPREG00000020726/ENSPREG00000017713/ENSPREG00000022950/ENSPREG00000009177/ENSPREG00000022527/ENSPREG00000007579/ENSPREG00000011881/ENSPREG00000019518/ENSPREG00000009192/ENSPREG00000010274/ENSPREG00000020729/ENSPREG00000004787/ENSPREG00000018664/ENSPREG00000018178/ENSPREG00000005065/ENSPREG00000021880/ENSPREG00000008883/ENSPREG00000003665/ENSPREG00000001294/ENSPREG00000014555/ENSPREG00000007076/ENSPREG00000016136/ENSPREG00000006582/ENSPREG00000001233/ENSPREG00000005355/ENSPREG00000010771/ENSPREG00000020589/ENSPREG00000007053/ENSPREG00000013242/ENSPREG00000010858/ENSPREG00000000238/ENSPREG00000006420/ENSPREG00000020999/ENSPREG00000012701/ENSPREG00000019203/ENSPREG00000021906/ENSPREG00000020842/ENSPREG00000015354/ENSPREG00000004736/ENSPREG00000008887/ENSPREG00000021889/ENSPREG00000020238/ENSPREG00000020121/ENSPREG00000022506/ENSPREG00000019331/ENSPREG00000003493/ENSPREG00000015415/ENSPREG00000018648/ENSPREG00000004412/ENSPREG00000019243/ENSPREG00000000217/ENSPREG00000015735/ENSPREG00000006734/ENSPREG00000006089/ENSPREG00000015076/ENSPREG00000020784/ENSPREG00000011159/ENSPREG00000009497/ENSPREG00000014165/ENSPREG00000023009/ENSPREG00000020144/ENSPREG00000019515/ENSPREG00000007168/ENSPREG00000007587/ENSPREG00000004722/ENSPREG00000002219/ENSPREG00000007682/ENSPREG00000011108/ENSPREG00000019374/ENSPREG00000014744/ENSPREG00000003147/ENSPREG00000019278/ENSPREG00000021620/ENSPREG00000005418/ENSPREG00000002834/ENSPREG00000020849/ENSPREG00000011786/ENSPREG00000022867/ENSPREG00000022823/ENSPREG00000015143/ENSPREG00000013831/ENSPREG00000015490/ENSPREG00000010443/ENSPREG00000021152/ENSPREG00000021603/ENSPREG00000000609/ENSPREG00000022193/ENSPREG00000003868/ENSPREG00000017285/ENSPREG00000006981/ENSPREG00000009060/ENSPREG00000002851/ENSPREG00000016554/ENSPREG00000023229/ENSPREG00000023230/ENSPREG00000013038/ENSPREG00000021765/ENSPREG00000019965/ENSPREG00000016334/ENSPREG00000006078/ENSPREG00000015414/ENSPREG00000003442/ENSPREG00000010187/ENSPREG00000017215/ENSPREG00000019985/ENSPREG00000017900/ENSPREG00000022843/ENSPREG00000002626/ENSPREG00000005289/ENSPREG00000023056/ENSPREG00000002655/ENSPREG00000021224/ENSPREG00000007115/ENSPREG00000018838/ENSPREG00000022428/ENSPREG00000018845/ENSPREG00000007220/ENSPREG00000018283/ENSPREG00000017608/ENSPREG00000002212/ENSPREG00000004944/ENSPREG00000015065/ENSPREG00000016766/ENSPREG00000000312/ENSPREG00000006112/ENSPREG00000016639/ENSPREG00000009142/ENSPREG00000021401/ENSPREG00000014854/ENSPREG00000010200/ENSPREG00000002472/ENSPREG00000008592/ENSPREG00000015786/ENSPREG00000002536/ENSPREG00000002006/ENSPREG00000018867/ENSPREG00000001738/ENSPREG00000021797/ENSPREG00000009332/ENSPREG00000020619/ENSPREG00000003595/ENSPREG00000012093/ENSPREG00000011758/ENSPREG00000014947/ENSPREG00000006918/ENSPREG00000020969/ENSPREG00000000313/ENSPREG00000014280/ENSPREG00000010078/ENSPREG00000019947/ENSPREG00000006378/ENSPREG00000011544/ENSPREG00000012267/ENSPREG00000009185/ENSPREG00000021867/ENSPREG00000018397/ENSPREG00000022223/ENSPREG00000008848/ENSPREG00000004715/ENSPREG00000020482/ENSPREG00000016686/ENSPREG00000000107/ENSPREG00000007668/ENSPREG00000010921/ENSPREG00000011471/ENSPREG00000009864/ENSPREG00000021638/ENSPREG00000010066/ENSPREG00000004477/ENSPREG00000012373/ENSPREG00000006183/ENSPREG00000003369/ENSPREG00000011250/ENSPREG00000015541/ENSPREG00000008818/ENSPREG00000010471/ENSPREG00000021294/ENSPREG00000017120
## GO:0030522 intracellular receptor signaling pathway ENSPREG00000018748/ENSPREG00000008698/ENSPREG00000013686/ENSPREG00000021486/ENSPREG00000009731/ENSPREG00000020437/ENSPREG00000001838/ENSPREG00000013209/ENSPREG00000009356/ENSPREG00000001562/ENSPREG00000004255/ENSPREG00000022630/ENSPREG00000011546
## GO:0003094 glomerular filtration ENSPREG00000018284/ENSPREG00000023226/ENSPREG00000012932/ENSPREG00000010531/ENSPREG00000001812/ENSPREG00000003411/ENSPREG00000013106
## GO:0009887 animal organ morphogenesis ENSPREG00000014489/ENSPREG00000008317/ENSPREG00000013601/ENSPREG00000021454/ENSPREG00000014440/ENSPREG00000020145/ENSPREG00000004048/ENSPREG00000018009
## GO:0045296 cadherin binding ENSPREG00000019281/ENSPREG00000013118/ENSPREG00000000452/ENSPREG00000006377/ENSPREG00000004309/ENSPREG00000009171
## GO:0045104 intermediate filament cytoskeleton organization ENSPREG00000022366/ENSPREG00000014518/ENSPREG00000006848/ENSPREG00000014532/ENSPREG00000015483/ENSPREG00000006810/ENSPREG00000019095/ENSPREG00000006918/ENSPREG00000014510
## GO:0048484 enteric nervous system development ENSPREG00000022019/ENSPREG00000017424/ENSPREG00000002079/ENSPREG00000000133/ENSPREG00000022300/ENSPREG00000018715/ENSPREG00000016745/ENSPREG00000002410/ENSPREG00000002978/ENSPREG00000020582
## GO:0021549 cerebellum development ENSPREG00000017475/ENSPREG00000013729/ENSPREG00000018368/ENSPREG00000013353/ENSPREG00000012091/ENSPREG00000008463/ENSPREG00000014912/ENSPREG00000020145
## GO:0006384 transcription initiation from RNA polymerase III promoter ENSPREG00000010651/ENSPREG00000000142/ENSPREG00000021756/ENSPREG00000008487
## GO:0032422 purine-rich negative regulatory element binding ENSPREG00000013084/ENSPREG00000019200/ENSPREG00000012322/ENSPREG00000015491
## Count
## GO:0060294 cilium movement involved in cell motility 6
## GO:0007275 multicellular organism development 142
## GO:0030837 negative regulation of actin filament polymerization 6
## GO:0006596 polyamine biosynthetic process 5
## GO:0030111 regulation of Wnt signaling pathway 5
## GO:0005515 protein binding 858
## GO:0030522 intracellular receptor signaling pathway 13
## GO:0003094 glomerular filtration 7
## GO:0009887 animal organ morphogenesis 8
## GO:0045296 cadherin binding 6
## GO:0045104 intermediate filament cytoskeleton organization 9
## GO:0048484 enteric nervous system development 10
## GO:0021549 cerebellum development 8
## GO:0006384 transcription initiation from RNA polymerase III promoter 4
## GO:0032422 purine-rich negative regulatory element binding 4CvGunion <- union(CvG_up,CvG_dn)
c_union <- enricher(gene = CvGunion, universe = CvG_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_union,15)## ID
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GO:0060294 cilium movement involved in cell motility GO:0060294 cilium movement involved in cell motility
## GO:1905606 regulation of presynapse assembly GO:1905606 regulation of presynapse assembly
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0009887 animal organ morphogenesis GO:0009887 animal organ morphogenesis
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0030522 intracellular receptor signaling pathway GO:0030522 intracellular receptor signaling pathway
## GO:0004879 nuclear receptor activity GO:0004879 nuclear receptor activity
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0030837 negative regulation of actin filament polymerization GO:0030837 negative regulation of actin filament polymerization
## GO:0007409 axonogenesis GO:0007409 axonogenesis
## GO:0032422 purine-rich negative regulatory element binding GO:0032422 purine-rich negative regulatory element binding
## GO:0003682 chromatin binding GO:0003682 chromatin binding
## GO:0022625 cytosolic large ribosomal subunit GO:0022625 cytosolic large ribosomal subunit
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## Description
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GO:0060294 cilium movement involved in cell motility GO:0060294 cilium movement involved in cell motility
## GO:1905606 regulation of presynapse assembly GO:1905606 regulation of presynapse assembly
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0009887 animal organ morphogenesis GO:0009887 animal organ morphogenesis
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0030522 intracellular receptor signaling pathway GO:0030522 intracellular receptor signaling pathway
## GO:0004879 nuclear receptor activity GO:0004879 nuclear receptor activity
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0030837 negative regulation of actin filament polymerization GO:0030837 negative regulation of actin filament polymerization
## GO:0007409 axonogenesis GO:0007409 axonogenesis
## GO:0032422 purine-rich negative regulatory element binding GO:0032422 purine-rich negative regulatory element binding
## GO:0003682 chromatin binding GO:0003682 chromatin binding
## GO:0022625 cytosolic large ribosomal subunit GO:0022625 cytosolic large ribosomal subunit
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GeneRatio
## GO:0046716 muscle cell cellular homeostasis 7/6129
## GO:0060294 cilium movement involved in cell motility 7/6129
## GO:1905606 regulation of presynapse assembly 7/6129
## GO:0007275 multicellular organism development 196/6129
## GO:0009887 animal organ morphogenesis 11/6129
## GO:0006355 regulation of transcription, DNA-templated 339/6129
## GO:0030522 intracellular receptor signaling pathway 17/6129
## GO:0004879 nuclear receptor activity 22/6129
## GO:0003677 DNA binding 428/6129
## GO:0030837 negative regulation of actin filament polymerization 7/6129
## GO:0007409 axonogenesis 22/6129
## GO:0032422 purine-rich negative regulatory element binding 5/6129
## GO:0003682 chromatin binding 23/6129
## GO:0022625 cytosolic large ribosomal subunit 6/6129
## GO:0030155 regulation of cell adhesion 6/6129
## BgRatio
## GO:0046716 muscle cell cellular homeostasis 7/18074
## GO:0060294 cilium movement involved in cell motility 7/18074
## GO:1905606 regulation of presynapse assembly 7/18074
## GO:0007275 multicellular organism development 480/18074
## GO:0009887 animal organ morphogenesis 14/18074
## GO:0006355 regulation of transcription, DNA-templated 876/18074
## GO:0030522 intracellular receptor signaling pathway 27/18074
## GO:0004879 nuclear receptor activity 38/18074
## GO:0003677 DNA binding 1132/18074
## GO:0030837 negative regulation of actin filament polymerization 8/18074
## GO:0007409 axonogenesis 39/18074
## GO:0032422 purine-rich negative regulatory element binding 5/18074
## GO:0003682 chromatin binding 43/18074
## GO:0022625 cytosolic large ribosomal subunit 7/18074
## GO:0030155 regulation of cell adhesion 7/18074
## pvalue
## GO:0046716 muscle cell cellular homeostasis 0.0005144741
## GO:0060294 cilium movement involved in cell motility 0.0005144741
## GO:1905606 regulation of presynapse assembly 0.0005144741
## GO:0007275 multicellular organism development 0.0007919458
## GO:0009887 animal organ morphogenesis 0.0008122831
## GO:0006355 regulation of transcription, DNA-templated 0.0013235115
## GO:0030522 intracellular receptor signaling pathway 0.0018930682
## GO:0004879 nuclear receptor activity 0.0020545323
## GO:0003677 DNA binding 0.0024784353
## GO:0030837 negative regulation of actin filament polymerization 0.0028954865
## GO:0007409 axonogenesis 0.0032165449
## GO:0032422 purine-rich negative regulatory element binding 0.0044792805
## GO:0003682 chromatin binding 0.0063749660
## GO:0022625 cytosolic large ribosomal subunit 0.0075400744
## GO:0030155 regulation of cell adhesion 0.0075400744
## p.adjust
## GO:0046716 muscle cell cellular homeostasis 0.2852738
## GO:0060294 cilium movement involved in cell motility 0.2852738
## GO:1905606 regulation of presynapse assembly 0.2852738
## GO:0007275 multicellular organism development 0.2852738
## GO:0009887 animal organ morphogenesis 0.2852738
## GO:0006355 regulation of transcription, DNA-templated 0.3873477
## GO:0030522 intracellular receptor signaling pathway 0.4509698
## GO:0004879 nuclear receptor activity 0.4509698
## GO:0003677 DNA binding 0.4835703
## GO:0030837 negative regulation of actin filament polymerization 0.5084474
## GO:0007409 axonogenesis 0.5134775
## GO:0032422 purine-rich negative regulatory element binding 0.6554680
## GO:0003682 chromatin binding 0.7617862
## GO:0022625 cytosolic large ribosomal subunit 0.7617862
## GO:0030155 regulation of cell adhesion 0.7617862
## qvalue
## GO:0046716 muscle cell cellular homeostasis 0.2850686
## GO:0060294 cilium movement involved in cell motility 0.2850686
## GO:1905606 regulation of presynapse assembly 0.2850686
## GO:0007275 multicellular organism development 0.2850686
## GO:0009887 animal organ morphogenesis 0.2850686
## GO:0006355 regulation of transcription, DNA-templated 0.3870691
## GO:0030522 intracellular receptor signaling pathway 0.4506454
## GO:0004879 nuclear receptor activity 0.4506454
## GO:0003677 DNA binding 0.4832224
## GO:0030837 negative regulation of actin filament polymerization 0.5080817
## GO:0007409 axonogenesis 0.5131082
## GO:0032422 purine-rich negative regulatory element binding 0.6549965
## GO:0003682 chromatin binding 0.7612382
## GO:0022625 cytosolic large ribosomal subunit 0.7612382
## GO:0030155 regulation of cell adhesion 0.7612382
## geneID
## GO:0046716 muscle cell cellular homeostasis ENSPREG00000009411/ENSPREG00000019794/ENSPREG00000020904/ENSPREG00000012706/ENSPREG00000002855/ENSPREG00000004187/ENSPREG00000020962
## GO:0060294 cilium movement involved in cell motility ENSPREG00000000366/ENSPREG00000009719/ENSPREG00000009761/ENSPREG00000012200/ENSPREG00000009128/ENSPREG00000020731/ENSPREG00000011030
## GO:1905606 regulation of presynapse assembly ENSPREG00000017257/ENSPREG00000008887/ENSPREG00000019248/ENSPREG00000019208/ENSPREG00000008897/ENSPREG00000002212/ENSPREG00000010471
## GO:0007275 multicellular organism development ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000021420/ENSPREG00000009198/ENSPREG00000014369/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011115/ENSPREG00000010035/ENSPREG00000007669/ENSPREG00000021106/ENSPREG00000011756/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000006396/ENSPREG00000001810/ENSPREG00000005385/ENSPREG00000001804/ENSPREG00000000557/ENSPREG00000020203/ENSPREG00000004862/ENSPREG00000020178/ENSPREG00000014079/ENSPREG00000021021/ENSPREG00000015614/ENSPREG00000004689/ENSPREG00000018739/ENSPREG00000021322/ENSPREG00000013196/ENSPREG00000013812/ENSPREG00000017782/ENSPREG00000021337/ENSPREG00000005821/ENSPREG00000010656/ENSPREG00000016605/ENSPREG00000012168/ENSPREG00000001888/ENSPREG00000000691/ENSPREG00000019836/ENSPREG00000023186/ENSPREG00000009681/ENSPREG00000022277/ENSPREG00000000563/ENSPREG00000014049/ENSPREG00000012582/ENSPREG00000000568/ENSPREG00000006008/ENSPREG00000017347/ENSPREG00000021010/ENSPREG00000009731/ENSPREG00000019321/ENSPREG00000016519/ENSPREG00000008801/ENSPREG00000016234/ENSPREG00000009154/ENSPREG00000017409/ENSPREG00000008761/ENSPREG00000006469/ENSPREG00000008357/ENSPREG00000003672/ENSPREG00000004813/ENSPREG00000006787/ENSPREG00000016476/ENSPREG00000002914/ENSPREG00000015884/ENSPREG00000006276/ENSPREG00000002117/ENSPREG00000011561/ENSPREG00000009183/ENSPREG00000007342/ENSPREG00000000683/ENSPREG00000002123/ENSPREG00000003235/ENSPREG00000000612/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000020332/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000018360/ENSPREG00000013766/ENSPREG00000003001/ENSPREG00000009481/ENSPREG00000016378/ENSPREG00000010783/ENSPREG00000003088/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000004667/ENSPREG00000009349/ENSPREG00000014773/ENSPREG00000010797/ENSPREG00000001340/ENSPREG00000017475/ENSPREG00000005101/ENSPREG00000000133/ENSPREG00000010790/ENSPREG00000008022/ENSPREG00000005343/ENSPREG00000006760/ENSPREG00000002673/ENSPREG00000001346/ENSPREG00000012541/ENSPREG00000011913/ENSPREG00000015465/ENSPREG00000013058/ENSPREG00000019287/ENSPREG00000013353/ENSPREG00000000532/ENSPREG00000021227/ENSPREG00000006758/ENSPREG00000006190/ENSPREG00000007900/ENSPREG00000012697/ENSPREG00000021274/ENSPREG00000020658/ENSPREG00000006606/ENSPREG00000015499/ENSPREG00000018135/ENSPREG00000001072/ENSPREG00000008300/ENSPREG00000018299/ENSPREG00000013601/ENSPREG00000008696/ENSPREG00000018652/ENSPREG00000011038/ENSPREG00000020206/ENSPREG00000010793/ENSPREG00000017901/ENSPREG00000006772/ENSPREG00000009363/ENSPREG00000015450/ENSPREG00000002053/ENSPREG00000013209/ENSPREG00000023206/ENSPREG00000001397/ENSPREG00000009356/ENSPREG00000004970/ENSPREG00000017077/ENSPREG00000005380/ENSPREG00000006819/ENSPREG00000011441/ENSPREG00000021949/ENSPREG00000006631/ENSPREG00000008297/ENSPREG00000019085/ENSPREG00000020667/ENSPREG00000002795/ENSPREG00000017001/ENSPREG00000001918/ENSPREG00000013048/ENSPREG00000020340/ENSPREG00000000163/ENSPREG00000003379/ENSPREG00000006929/ENSPREG00000021144/ENSPREG00000011620/ENSPREG00000008016/ENSPREG00000012105/ENSPREG00000015326/ENSPREG00000008325/ENSPREG00000011721/ENSPREG00000011089/ENSPREG00000013684/ENSPREG00000014000/ENSPREG00000002598/ENSPREG00000023212/ENSPREG00000020538/ENSPREG00000001265/ENSPREG00000022538/ENSPREG00000015189/ENSPREG00000013636/ENSPREG00000003992/ENSPREG00000006101/ENSPREG00000005482/ENSPREG00000003325/ENSPREG00000014120/ENSPREG00000002679/ENSPREG00000019531/ENSPREG00000006981/ENSPREG00000021597/ENSPREG00000004436/ENSPREG00000019962/ENSPREG00000018009/ENSPREG00000007418/ENSPREG00000017669/ENSPREG00000014038/ENSPREG00000020848/ENSPREG00000003491/ENSPREG00000009171/ENSPREG00000023233/ENSPREG00000001369/ENSPREG00000006716/ENSPREG00000010959/ENSPREG00000002135
## GO:0009887 animal organ morphogenesis ENSPREG00000001620/ENSPREG00000013898/ENSPREG00000006008/ENSPREG00000014489/ENSPREG00000008317/ENSPREG00000013601/ENSPREG00000021454/ENSPREG00000014440/ENSPREG00000020145/ENSPREG00000004048/ENSPREG00000018009
## GO:0006355 regulation of transcription, DNA-templated ENSPREG00000022182/ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000012138/ENSPREG00000021365/ENSPREG00000009198/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000012367/ENSPREG00000004029/ENSPREG00000011115/ENSPREG00000012663/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000018974/ENSPREG00000020011/ENSPREG00000009540/ENSPREG00000012965/ENSPREG00000006396/ENSPREG00000001810/ENSPREG00000001771/ENSPREG00000005385/ENSPREG00000012188/ENSPREG00000002057/ENSPREG00000000557/ENSPREG00000016872/ENSPREG00000019859/ENSPREG00000020203/ENSPREG00000020178/ENSPREG00000016918/ENSPREG00000022421/ENSPREG00000007159/ENSPREG00000015981/ENSPREG00000006450/ENSPREG00000021021/ENSPREG00000009977/ENSPREG00000019566/ENSPREG00000000662/ENSPREG00000019055/ENSPREG00000004689/ENSPREG00000015427/ENSPREG00000022772/ENSPREG00000023177/ENSPREG00000010182/ENSPREG00000013196/ENSPREG00000013812/ENSPREG00000000694/ENSPREG00000020853/ENSPREG00000010340/ENSPREG00000000792/ENSPREG00000013087/ENSPREG00000021337/ENSPREG00000005821/ENSPREG00000010656/ENSPREG00000011269/ENSPREG00000010804/ENSPREG00000012168/ENSPREG00000002999/ENSPREG00000007634/ENSPREG00000018925/ENSPREG00000019840/ENSPREG00000000691/ENSPREG00000019836/ENSPREG00000021173/ENSPREG00000023186/ENSPREG00000015542/ENSPREG00000010594/ENSPREG00000004185/ENSPREG00000008193/ENSPREG00000022470/ENSPREG00000009681/ENSPREG00000017805/ENSPREG00000014207/ENSPREG00000021778/ENSPREG00000007944/ENSPREG00000000563/ENSPREG00000014049/ENSPREG00000010877/ENSPREG00000015529/ENSPREG00000013420/ENSPREG00000012582/ENSPREG00000011959/ENSPREG00000017887/ENSPREG00000000568/ENSPREG00000011930/ENSPREG00000019537/ENSPREG00000013848/ENSPREG00000018196/ENSPREG00000009731/ENSPREG00000019321/ENSPREG00000016519/ENSPREG00000020502/ENSPREG00000016234/ENSPREG00000021553/ENSPREG00000003428/ENSPREG00000018909/ENSPREG00000003901/ENSPREG00000008761/ENSPREG00000019519/ENSPREG00000023202/ENSPREG00000020875/ENSPREG00000022614/ENSPREG00000005028/ENSPREG00000014025/ENSPREG00000018193/ENSPREG00000006787/ENSPREG00000012532/ENSPREG00000001758/ENSPREG00000014097/ENSPREG00000021437/ENSPREG00000008490/ENSPREG00000010581/ENSPREG00000023255/ENSPREG00000006111/ENSPREG00000019601/ENSPREG00000015884/ENSPREG00000018399/ENSPREG00000004655/ENSPREG00000006276/ENSPREG00000002510/ENSPREG00000018613/ENSPREG00000002117/ENSPREG00000016109/ENSPREG00000004444/ENSPREG00000023092/ENSPREG00000014446/ENSPREG00000008337/ENSPREG00000007342/ENSPREG00000000683/ENSPREG00000002123/ENSPREG00000010907/ENSPREG00000001824/ENSPREG00000005256/ENSPREG00000006142/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000018881/ENSPREG00000013623/ENSPREG00000014745/ENSPREG00000008785/ENSPREG00000018748/ENSPREG00000020332/ENSPREG00000011064/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000003743/ENSPREG00000021136/ENSPREG00000013766/ENSPREG00000022546/ENSPREG00000016676/ENSPREG00000018249/ENSPREG00000013315/ENSPREG00000003001/ENSPREG00000001543/ENSPREG00000014960/ENSPREG00000010783/ENSPREG00000008698/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000013995/ENSPREG00000001598/ENSPREG00000014513/ENSPREG00000013775/ENSPREG00000022267/ENSPREG00000010797/ENSPREG00000004647/ENSPREG00000001340/ENSPREG00000012699/ENSPREG00000003063/ENSPREG00000021875/ENSPREG00000017475/ENSPREG00000010086/ENSPREG00000011212/ENSPREG00000011922/ENSPREG00000004232/ENSPREG00000011677/ENSPREG00000013686/ENSPREG00000013067/ENSPREG00000022899/ENSPREG00000022906/ENSPREG00000022501/ENSPREG00000009351/ENSPREG00000018224/ENSPREG00000003447/ENSPREG00000005343/ENSPREG00000007592/ENSPREG00000017239/ENSPREG00000006760/ENSPREG00000021782/ENSPREG00000001346/ENSPREG00000005281/ENSPREG00000007997/ENSPREG00000022910/ENSPREG00000007429/ENSPREG00000005246/ENSPREG00000019546/ENSPREG00000012541/ENSPREG00000013386/ENSPREG00000001360/ENSPREG00000011913/ENSPREG00000016689/ENSPREG00000015465/ENSPREG00000013058/ENSPREG00000020458/ENSPREG00000013353/ENSPREG00000000532/ENSPREG00000011189/ENSPREG00000021227/ENSPREG00000011940/ENSPREG00000006758/ENSPREG00000013403/ENSPREG00000014467/ENSPREG00000007900/ENSPREG00000007793/ENSPREG00000017420/ENSPREG00000018379/ENSPREG00000006606/ENSPREG00000015499/ENSPREG00000011231/ENSPREG00000013828/ENSPREG00000020437/ENSPREG00000015916/ENSPREG00000014608/ENSPREG00000011080/ENSPREG00000022066/ENSPREG00000008300/ENSPREG00000013601/ENSPREG00000001229/ENSPREG00000016099/ENSPREG00000000511/ENSPREG00000006956/ENSPREG00000009598/ENSPREG00000008402/ENSPREG00000013840/ENSPREG00000017901/ENSPREG00000006772/ENSPREG00000009363/ENSPREG00000015450/ENSPREG00000001838/ENSPREG00000023222/ENSPREG00000013209/ENSPREG00000020804/ENSPREG00000010841/ENSPREG00000021982/ENSPREG00000000419/ENSPREG00000008918/ENSPREG00000023206/ENSPREG00000016508/ENSPREG00000016361/ENSPREG00000001397/ENSPREG00000009356/ENSPREG00000004970/ENSPREG00000015213/ENSPREG00000002018/ENSPREG00000017077/ENSPREG00000019823/ENSPREG00000016909/ENSPREG00000013445/ENSPREG00000008815/ENSPREG00000005380/ENSPREG00000006819/ENSPREG00000004558/ENSPREG00000011441/ENSPREG00000005893/ENSPREG00000015273/ENSPREG00000001562/ENSPREG00000006631/ENSPREG00000008297/ENSPREG00000002795/ENSPREG00000017001/ENSPREG00000004255/ENSPREG00000018558/ENSPREG00000013048/ENSPREG00000020340/ENSPREG00000005578/ENSPREG00000011918/ENSPREG00000006929/ENSPREG00000022851/ENSPREG00000011620/ENSPREG00000022410/ENSPREG00000019385/ENSPREG00000012105/ENSPREG00000015326/ENSPREG00000014440/ENSPREG00000012369/ENSPREG00000022630/ENSPREG00000004743/ENSPREG00000015826/ENSPREG00000018387/ENSPREG00000007919/ENSPREG00000011986/ENSPREG00000011721/ENSPREG00000005288/ENSPREG00000011089/ENSPREG00000014823/ENSPREG00000013684/ENSPREG00000017575/ENSPREG00000018453/ENSPREG00000023212/ENSPREG00000020538/ENSPREG00000022538/ENSPREG00000015189/ENSPREG00000017352/ENSPREG00000016928/ENSPREG00000004628/ENSPREG00000005784/ENSPREG00000019842/ENSPREG00000013636/ENSPREG00000006101/ENSPREG00000003325/ENSPREG00000019278/ENSPREG00000008832/ENSPREG00000010102/ENSPREG00000001997/ENSPREG00000019531/ENSPREG00000004404/ENSPREG00000022723/ENSPREG00000002851/ENSPREG00000007996/ENSPREG00000002788/ENSPREG00000016149/ENSPREG00000011546/ENSPREG00000007760/ENSPREG00000021597/ENSPREG00000004436/ENSPREG00000019962/ENSPREG00000017669/ENSPREG00000014038/ENSPREG00000003491/ENSPREG00000018746/ENSPREG00000016639/ENSPREG00000021316/ENSPREG00000000313/ENSPREG00000017180/ENSPREG00000011544/ENSPREG00000006716/ENSPREG00000010959/ENSPREG00000002135/ENSPREG00000002926
## GO:0030522 intracellular receptor signaling pathway ENSPREG00000000694/ENSPREG00000021486/ENSPREG00000009731/ENSPREG00000016519/ENSPREG00000008761/ENSPREG00000001824/ENSPREG00000018748/ENSPREG00000008698/ENSPREG00000013686/ENSPREG00000020437/ENSPREG00000001838/ENSPREG00000013209/ENSPREG00000009356/ENSPREG00000001562/ENSPREG00000004255/ENSPREG00000022630/ENSPREG00000011546
## GO:0004879 nuclear receptor activity ENSPREG00000000694/ENSPREG00000013420/ENSPREG00000021486/ENSPREG00000009731/ENSPREG00000016519/ENSPREG00000020502/ENSPREG00000008761/ENSPREG00000002510/ENSPREG00000001824/ENSPREG00000018748/ENSPREG00000008698/ENSPREG00000001598/ENSPREG00000013686/ENSPREG00000020437/ENSPREG00000001838/ENSPREG00000013209/ENSPREG00000009356/ENSPREG00000001562/ENSPREG00000004255/ENSPREG00000022630/ENSPREG00000011986/ENSPREG00000011546
## GO:0003677 DNA binding ENSPREG00000001606/ENSPREG00000022182/ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000012138/ENSPREG00000021365/ENSPREG00000009198/ENSPREG00000014369/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000014523/ENSPREG00000012367/ENSPREG00000004029/ENSPREG00000011115/ENSPREG00000012663/ENSPREG00000010341/ENSPREG00000019599/ENSPREG00000006777/ENSPREG00000008233/ENSPREG00000006061/ENSPREG00000019092/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000012965/ENSPREG00000006239/ENSPREG00000022564/ENSPREG00000000237/ENSPREG00000004107/ENSPREG00000006396/ENSPREG00000000142/ENSPREG00000005385/ENSPREG00000012188/ENSPREG00000000557/ENSPREG00000004218/ENSPREG00000016872/ENSPREG00000019859/ENSPREG00000020203/ENSPREG00000020178/ENSPREG00000016918/ENSPREG00000003633/ENSPREG00000007159/ENSPREG00000006450/ENSPREG00000021021/ENSPREG00000005993/ENSPREG00000009977/ENSPREG00000020070/ENSPREG00000019566/ENSPREG00000002923/ENSPREG00000019055/ENSPREG00000004689/ENSPREG00000015427/ENSPREG00000022772/ENSPREG00000016530/ENSPREG00000023177/ENSPREG00000013196/ENSPREG00000013812/ENSPREG00000017782/ENSPREG00000000694/ENSPREG00000020876/ENSPREG00000010340/ENSPREG00000000792/ENSPREG00000021337/ENSPREG00000005821/ENSPREG00000010656/ENSPREG00000010174/ENSPREG00000016605/ENSPREG00000012168/ENSPREG00000002999/ENSPREG00000012499/ENSPREG00000001380/ENSPREG00000000691/ENSPREG00000022948/ENSPREG00000019836/ENSPREG00000018786/ENSPREG00000021173/ENSPREG00000023186/ENSPREG00000018635/ENSPREG00000021824/ENSPREG00000021669/ENSPREG00000015542/ENSPREG00000004185/ENSPREG00000008193/ENSPREG00000009681/ENSPREG00000007643/ENSPREG00000017805/ENSPREG00000014207/ENSPREG00000021778/ENSPREG00000007944/ENSPREG00000022277/ENSPREG00000000563/ENSPREG00000014049/ENSPREG00000015529/ENSPREG00000002624/ENSPREG00000013420/ENSPREG00000012582/ENSPREG00000008773/ENSPREG00000008666/ENSPREG00000006219/ENSPREG00000000568/ENSPREG00000021397/ENSPREG00000019537/ENSPREG00000017347/ENSPREG00000002632/ENSPREG00000021486/ENSPREG00000009731/ENSPREG00000019321/ENSPREG00000016519/ENSPREG00000020502/ENSPREG00000018936/ENSPREG00000011223/ENSPREG00000016234/ENSPREG00000021553/ENSPREG00000017409/ENSPREG00000003428/ENSPREG00000013985/ENSPREG00000007985/ENSPREG00000003901/ENSPREG00000008761/ENSPREG00000006445/ENSPREG00000015252/ENSPREG00000019519/ENSPREG00000014770/ENSPREG00000020875/ENSPREG00000022614/ENSPREG00000020281/ENSPREG00000015870/ENSPREG00000004813/ENSPREG00000014025/ENSPREG00000018193/ENSPREG00000006787/ENSPREG00000017553/ENSPREG00000001758/ENSPREG00000004595/ENSPREG00000018117/ENSPREG00000023255/ENSPREG00000019601/ENSPREG00000015884/ENSPREG00000022145/ENSPREG00000018761/ENSPREG00000006276/ENSPREG00000002510/ENSPREG00000002117/ENSPREG00000016109/ENSPREG00000004444/ENSPREG00000023092/ENSPREG00000014446/ENSPREG00000008337/ENSPREG00000012260/ENSPREG00000012718/ENSPREG00000008684/ENSPREG00000004845/ENSPREG00000008636/ENSPREG00000007342/ENSPREG00000000683/ENSPREG00000002123/ENSPREG00000019101/ENSPREG00000004581/ENSPREG00000017112/ENSPREG00000001824/ENSPREG00000005256/ENSPREG00000014876/ENSPREG00000017164/ENSPREG00000018820/ENSPREG00000022956/ENSPREG00000004266/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000001592/ENSPREG00000018881/ENSPREG00000013623/ENSPREG00000011707/ENSPREG00000014745/ENSPREG00000008785/ENSPREG00000018748/ENSPREG00000020394/ENSPREG00000010865/ENSPREG00000020332/ENSPREG00000011064/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000022075/ENSPREG00000000414/ENSPREG00000013766/ENSPREG00000004023/ENSPREG00000016676/ENSPREG00000018249/ENSPREG00000013315/ENSPREG00000003001/ENSPREG00000011305/ENSPREG00000019479/ENSPREG00000008043/ENSPREG00000010061/ENSPREG00000014960/ENSPREG00000010783/ENSPREG00000008698/ENSPREG00000019423/ENSPREG00000014413/ENSPREG00000002904/ENSPREG00000009851/ENSPREG00000003088/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000013995/ENSPREG00000001598/ENSPREG00000007733/ENSPREG00000018024/ENSPREG00000014215/ENSPREG00000014513/ENSPREG00000013122/ENSPREG00000013775/ENSPREG00000022267/ENSPREG00000010797/ENSPREG00000004647/ENSPREG00000001340/ENSPREG00000009470/ENSPREG00000006621/ENSPREG00000012699/ENSPREG00000003063/ENSPREG00000008234/ENSPREG00000017475/ENSPREG00000011212/ENSPREG00000012254/ENSPREG00000004232/ENSPREG00000022924/ENSPREG00000013686/ENSPREG00000013067/ENSPREG00000022899/ENSPREG00000022906/ENSPREG00000022501/ENSPREG00000018873/ENSPREG00000009351/ENSPREG00000003939/ENSPREG00000008940/ENSPREG00000018224/ENSPREG00000005343/ENSPREG00000011400/ENSPREG00000017239/ENSPREG00000010913/ENSPREG00000012739/ENSPREG00000006760/ENSPREG00000000939/ENSPREG00000001346/ENSPREG00000002892/ENSPREG00000007818/ENSPREG00000005281/ENSPREG00000015073/ENSPREG00000004289/ENSPREG00000019546/ENSPREG00000012541/ENSPREG00000013386/ENSPREG00000020249/ENSPREG00000001360/ENSPREG00000015816/ENSPREG00000011913/ENSPREG00000016689/ENSPREG00000015465/ENSPREG00000008658/ENSPREG00000019200/ENSPREG00000013058/ENSPREG00000020458/ENSPREG00000019908/ENSPREG00000022812/ENSPREG00000013353/ENSPREG00000000532/ENSPREG00000021227/ENSPREG00000006758/ENSPREG00000006190/ENSPREG00000005805/ENSPREG00000014467/ENSPREG00000007900/ENSPREG00000009925/ENSPREG00000008418/ENSPREG00000017420/ENSPREG00000006077/ENSPREG00000016014/ENSPREG00000021274/ENSPREG00000012831/ENSPREG00000006606/ENSPREG00000015499/ENSPREG00000011231/ENSPREG00000013828/ENSPREG00000020437/ENSPREG00000015916/ENSPREG00000012063/ENSPREG00000012322/ENSPREG00000022066/ENSPREG00000008300/ENSPREG00000002591/ENSPREG00000018299/ENSPREG00000013601/ENSPREG00000008696/ENSPREG00000022283/ENSPREG00000009074/ENSPREG00000020206/ENSPREG00000014071/ENSPREG00000008141/ENSPREG00000009598/ENSPREG00000019019/ENSPREG00000008402/ENSPREG00000010196/ENSPREG00000013840/ENSPREG00000017901/ENSPREG00000006772/ENSPREG00000015450/ENSPREG00000001838/ENSPREG00000020918/ENSPREG00000008307/ENSPREG00000023222/ENSPREG00000019590/ENSPREG00000013209/ENSPREG00000008561/ENSPREG00000008918/ENSPREG00000023206/ENSPREG00000001397/ENSPREG00000013064/ENSPREG00000015468/ENSPREG00000009356/ENSPREG00000004970/ENSPREG00000002018/ENSPREG00000017077/ENSPREG00000008815/ENSPREG00000005380/ENSPREG00000006489/ENSPREG00000006819/ENSPREG00000011441/ENSPREG00000003558/ENSPREG00000018000/ENSPREG00000005612/ENSPREG00000001562/ENSPREG00000006631/ENSPREG00000008297/ENSPREG00000016663/ENSPREG00000002795/ENSPREG00000005286/ENSPREG00000016198/ENSPREG00000008992/ENSPREG00000017001/ENSPREG00000004255/ENSPREG00000018558/ENSPREG00000020287/ENSPREG00000020316/ENSPREG00000008197/ENSPREG00000008128/ENSPREG00000010379/ENSPREG00000021229/ENSPREG00000013048/ENSPREG00000020340/ENSPREG00000005578/ENSPREG00000011918/ENSPREG00000003379/ENSPREG00000006929/ENSPREG00000009834/ENSPREG00000011620/ENSPREG00000007407/ENSPREG00000022410/ENSPREG00000019385/ENSPREG00000012105/ENSPREG00000015326/ENSPREG00000014440/ENSPREG00000022630/ENSPREG00000004743/ENSPREG00000018387/ENSPREG00000007919/ENSPREG00000011986/ENSPREG00000011721/ENSPREG00000005288/ENSPREG00000011089/ENSPREG00000013684/ENSPREG00000014000/ENSPREG00000000278/ENSPREG00000017575/ENSPREG00000022971/ENSPREG00000018453/ENSPREG00000023212/ENSPREG00000020538/ENSPREG00000015004/ENSPREG00000022538/ENSPREG00000011292/ENSPREG00000000206/ENSPREG00000006003/ENSPREG00000017894/ENSPREG00000015189/ENSPREG00000015491/ENSPREG00000012015/ENSPREG00000010391/ENSPREG00000004628/ENSPREG00000017050/ENSPREG00000017276/ENSPREG00000013636/ENSPREG00000003992/ENSPREG00000006101/ENSPREG00000003325/ENSPREG00000014120/ENSPREG00000019278/ENSPREG00000017296/ENSPREG00000006187/ENSPREG00000008832/ENSPREG00000010102/ENSPREG00000001997/ENSPREG00000019531/ENSPREG00000022723/ENSPREG00000007996/ENSPREG00000002788/ENSPREG00000016149/ENSPREG00000011546/ENSPREG00000007760/ENSPREG00000021597/ENSPREG00000004436/ENSPREG00000003838/ENSPREG00000019962/ENSPREG00000004836/ENSPREG00000000466/ENSPREG00000004192/ENSPREG00000017669/ENSPREG00000014038/ENSPREG00000003491/ENSPREG00000018746/ENSPREG00000002849/ENSPREG00000016639/ENSPREG00000015289/ENSPREG00000001369/ENSPREG00000017180/ENSPREG00000011544/ENSPREG00000006716/ENSPREG00000010959/ENSPREG00000002135/ENSPREG00000002926/ENSPREG00000017120
## GO:0030837 negative regulation of actin filament polymerization ENSPREG00000004859/ENSPREG00000012026/ENSPREG00000009872/ENSPREG00000002396/ENSPREG00000022136/ENSPREG00000006482/ENSPREG00000005608
## GO:0007409 axonogenesis ENSPREG00000003714/ENSPREG00000009462/ENSPREG00000017257/ENSPREG00000019606/ENSPREG00000008887/ENSPREG00000013382/ENSPREG00000019248/ENSPREG00000007334/ENSPREG00000004376/ENSPREG00000000399/ENSPREG00000019454/ENSPREG00000019208/ENSPREG00000011222/ENSPREG00000009298/ENSPREG00000008300/ENSPREG00000008897/ENSPREG00000022658/ENSPREG00000021457/ENSPREG00000021949/ENSPREG00000005824/ENSPREG00000002212/ENSPREG00000010471
## GO:0032422 purine-rich negative regulatory element binding ENSPREG00000004218/ENSPREG00000013084/ENSPREG00000019200/ENSPREG00000012322/ENSPREG00000015491
## GO:0003682 chromatin binding ENSPREG00000020416/ENSPREG00000016522/ENSPREG00000001380/ENSPREG00000007118/ENSPREG00000018256/ENSPREG00000007490/ENSPREG00000005028/ENSPREG00000015840/ENSPREG00000019882/ENSPREG00000002725/ENSPREG00000012260/ENSPREG00000019101/ENSPREG00000005463/ENSPREG00000004390/ENSPREG00000010086/ENSPREG00000002892/ENSPREG00000021274/ENSPREG00000008229/ENSPREG00000016999/ENSPREG00000008561/ENSPREG00000015213/ENSPREG00000011721/ENSPREG00000022723
## GO:0022625 cytosolic large ribosomal subunit ENSPREG00000022060/ENSPREG00000008655/ENSPREG00000008614/ENSPREG00000020132/ENSPREG00000022664/ENSPREG00000011980
## GO:0030155 regulation of cell adhesion ENSPREG00000020191/ENSPREG00000010044/ENSPREG00000011543/ENSPREG00000019336/ENSPREG00000006389/ENSPREG00000021917
## Count
## GO:0046716 muscle cell cellular homeostasis 7
## GO:0060294 cilium movement involved in cell motility 7
## GO:1905606 regulation of presynapse assembly 7
## GO:0007275 multicellular organism development 196
## GO:0009887 animal organ morphogenesis 11
## GO:0006355 regulation of transcription, DNA-templated 339
## GO:0030522 intracellular receptor signaling pathway 17
## GO:0004879 nuclear receptor activity 22
## GO:0003677 DNA binding 428
## GO:0030837 negative regulation of actin filament polymerization 7
## GO:0007409 axonogenesis 22
## GO:0032422 purine-rich negative regulatory element binding 5
## GO:0003682 chromatin binding 23
## GO:0022625 cytosolic large ribosomal subunit 6
## GO:0030155 regulation of cell adhesion 6library(reshape2)
CvG_up <- subset(CvG,meth.diff>0&qvalue<0.001)
CvG_up <- unique(CvG_up$gene_id)
str(CvG_up)## chr [1:519] "ENSPREG00000021468" "ENSPREG00000021490" "ENSPREG00000000312" ...CvG_dn <- subset(CvG,meth.diff<0&qvalue<0.001)
CvG_dn <- unique(CvG_dn$gene_id)
str(CvG_dn)## chr [1:973] "ENSPREG00000004582" "ENSPREG00000004594" "ENSPREG00000003390" ...CvG_bg <- unique(CvG$gene_id)
str(CvG_bg)## chr [1:21591] "ENSPREG00000021468" "ENSPREG00000021490" ...c_up <- enricher(gene = CvG_up, universe = CvG_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_up,15)## ID
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008543 fibroblast growth factor receptor signaling pathway
## GO:0009253 peptidoglycan catabolic process GO:0009253 peptidoglycan catabolic process
## GO:0035256 G protein-coupled glutamate receptor binding GO:0035256 G protein-coupled glutamate receptor binding
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
## GO:0035479 angioblast cell migration from lateral mesoderm to midline GO:0035479 angioblast cell migration from lateral mesoderm to midline
## GO:0046580 negative regulation of Ras protein signal transduction GO:0046580 negative regulation of Ras protein signal transduction
## GO:0008270 zinc ion binding GO:0008270 zinc ion binding
## GO:0001525 angiogenesis GO:0001525 angiogenesis
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GO:0045176 apical protein localization GO:0045176 apical protein localization
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0003924 GTPase activity GO:0003924 GTPase activity
## Description
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008543 fibroblast growth factor receptor signaling pathway
## GO:0009253 peptidoglycan catabolic process GO:0009253 peptidoglycan catabolic process
## GO:0035256 G protein-coupled glutamate receptor binding GO:0035256 G protein-coupled glutamate receptor binding
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
## GO:0035479 angioblast cell migration from lateral mesoderm to midline GO:0035479 angioblast cell migration from lateral mesoderm to midline
## GO:0046580 negative regulation of Ras protein signal transduction GO:0046580 negative regulation of Ras protein signal transduction
## GO:0008270 zinc ion binding GO:0008270 zinc ion binding
## GO:0001525 angiogenesis GO:0001525 angiogenesis
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GO:0045176 apical protein localization GO:0045176 apical protein localization
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0003924 GTPase activity GO:0003924 GTPase activity
## GeneRatio
## GO:0006357 regulation of transcription by RNA polymerase II 18/430
## GO:0043087 regulation of GTPase activity 4/430
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 14/430
## GO:0008543 fibroblast growth factor receptor signaling pathway 4/430
## GO:0009253 peptidoglycan catabolic process 2/430
## GO:0035256 G protein-coupled glutamate receptor binding 2/430
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 2/430
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 2/430
## GO:0046580 negative regulation of Ras protein signal transduction 2/430
## GO:0008270 zinc ion binding 27/430
## GO:0001525 angiogenesis 7/430
## GO:0030155 regulation of cell adhesion 2/430
## GO:0045176 apical protein localization 2/430
## GO:0007275 multicellular organism development 20/430
## GO:0003924 GTPase activity 14/430
## BgRatio
## GO:0006357 regulation of transcription by RNA polymerase II 370/18074
## GO:0043087 regulation of GTPase activity 27/18074
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18074
## GO:0008543 fibroblast growth factor receptor signaling pathway 30/18074
## GO:0009253 peptidoglycan catabolic process 5/18074
## GO:0035256 G protein-coupled glutamate receptor binding 5/18074
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 5/18074
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 6/18074
## GO:0046580 negative regulation of Ras protein signal transduction 6/18074
## GO:0008270 zinc ion binding 694/18074
## GO:0001525 angiogenesis 99/18074
## GO:0030155 regulation of cell adhesion 7/18074
## GO:0045176 apical protein localization 7/18074
## GO:0007275 multicellular organism development 480/18074
## GO:0003924 GTPase activity 300/18074
## pvalue
## GO:0006357 regulation of transcription by RNA polymerase II 0.003451916
## GO:0043087 regulation of GTPase activity 0.003593029
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.003913300
## GO:0008543 fibroblast growth factor receptor signaling pathway 0.005304989
## GO:0009253 peptidoglycan catabolic process 0.005384525
## GO:0035256 G protein-coupled glutamate receptor binding 0.005384525
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.005384525
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.007950019
## GO:0046580 negative regulation of Ras protein signal transduction 0.007950019
## GO:0008270 zinc ion binding 0.008704361
## GO:0001525 angiogenesis 0.009379973
## GO:0030155 regulation of cell adhesion 0.010955685
## GO:0045176 apical protein localization 0.010955685
## GO:0007275 multicellular organism development 0.011329772
## GO:0003924 GTPase activity 0.013046373
## p.adjust
## GO:0006357 regulation of transcription by RNA polymerase II 0.4846072
## GO:0043087 regulation of GTPase activity 0.4846072
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4846072
## GO:0008543 fibroblast growth factor receptor signaling pathway 0.4846072
## GO:0009253 peptidoglycan catabolic process 0.4846072
## GO:0035256 G protein-coupled glutamate receptor binding 0.4846072
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.4846072
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.5046879
## GO:0046580 negative regulation of Ras protein signal transduction 0.5046879
## GO:0008270 zinc ion binding 0.5046879
## GO:0001525 angiogenesis 0.5046879
## GO:0030155 regulation of cell adhesion 0.5046879
## GO:0045176 apical protein localization 0.5046879
## GO:0007275 multicellular organism development 0.5046879
## GO:0003924 GTPase activity 0.5046879
## qvalue
## GO:0006357 regulation of transcription by RNA polymerase II 0.4704374
## GO:0043087 regulation of GTPase activity 0.4704374
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4704374
## GO:0008543 fibroblast growth factor receptor signaling pathway 0.4704374
## GO:0009253 peptidoglycan catabolic process 0.4704374
## GO:0035256 G protein-coupled glutamate receptor binding 0.4704374
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.4704374
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.4899309
## GO:0046580 negative regulation of Ras protein signal transduction 0.4899309
## GO:0008270 zinc ion binding 0.4899309
## GO:0001525 angiogenesis 0.4899309
## GO:0030155 regulation of cell adhesion 0.4899309
## GO:0045176 apical protein localization 0.4899309
## GO:0007275 multicellular organism development 0.4899309
## GO:0003924 GTPase activity 0.4899309
## geneID
## GO:0006357 regulation of transcription by RNA polymerase II ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000007804/ENSPREG00000009198/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011115/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000000237/ENSPREG00000016394/ENSPREG00000006396/ENSPREG00000020443/ENSPREG00000005385/ENSPREG00000012188/ENSPREG00000002057/ENSPREG00000000557
## GO:0043087 regulation of GTPase activity ENSPREG00000017857/ENSPREG00000008324/ENSPREG00000004344/ENSPREG00000021572
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000009198/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011115/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000006396/ENSPREG00000005385/ENSPREG00000012188/ENSPREG00000002057/ENSPREG00000000557
## GO:0008543 fibroblast growth factor receptor signaling pathway ENSPREG00000021677/ENSPREG00000008601/ENSPREG00000009500/ENSPREG00000003394
## GO:0009253 peptidoglycan catabolic process ENSPREG00000017510/ENSPREG00000017953
## GO:0035256 G protein-coupled glutamate receptor binding ENSPREG00000003004/ENSPREG00000009990
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ENSPREG00000008541/ENSPREG00000004394
## GO:0035479 angioblast cell migration from lateral mesoderm to midline ENSPREG00000011756/ENSPREG00000010859
## GO:0046580 negative regulation of Ras protein signal transduction ENSPREG00000017857/ENSPREG00000004344
## GO:0008270 zinc ion binding ENSPREG00000022182/ENSPREG00000005325/ENSPREG00000012138/ENSPREG00000017953/ENSPREG00000001755/ENSPREG00000018405/ENSPREG00000014023/ENSPREG00000017981/ENSPREG00000021715/ENSPREG00000017808/ENSPREG00000000488/ENSPREG00000012663/ENSPREG00000022214/ENSPREG00000010537/ENSPREG00000008233/ENSPREG00000009540/ENSPREG00000014502/ENSPREG00000000237/ENSPREG00000002840/ENSPREG00000008349/ENSPREG00000009995/ENSPREG00000012188/ENSPREG00000017244/ENSPREG00000022502/ENSPREG00000023192/ENSPREG00000017520/ENSPREG00000002000
## GO:0001525 angiogenesis ENSPREG00000015617/ENSPREG00000000208/ENSPREG00000010035/ENSPREG00000001009/ENSPREG00000011756/ENSPREG00000001810/ENSPREG00000007027
## GO:0030155 regulation of cell adhesion ENSPREG00000020191/ENSPREG00000010044
## GO:0045176 apical protein localization ENSPREG00000018047/ENSPREG00000014551
## GO:0007275 multicellular organism development ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000021420/ENSPREG00000009198/ENSPREG00000014369/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011115/ENSPREG00000010035/ENSPREG00000007669/ENSPREG00000021106/ENSPREG00000011756/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000006396/ENSPREG00000001810/ENSPREG00000005385/ENSPREG00000001804/ENSPREG00000000557
## GO:0003924 GTPase activity ENSPREG00000014888/ENSPREG00000007438/ENSPREG00000014819/ENSPREG00000022241/ENSPREG00000005797/ENSPREG00000004803/ENSPREG00000017707/ENSPREG00000009158/ENSPREG00000019561/ENSPREG00000006955/ENSPREG00000003821/ENSPREG00000008323/ENSPREG00000008165/ENSPREG00000006630
## Count
## GO:0006357 regulation of transcription by RNA polymerase II 18
## GO:0043087 regulation of GTPase activity 4
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 14
## GO:0008543 fibroblast growth factor receptor signaling pathway 4
## GO:0009253 peptidoglycan catabolic process 2
## GO:0035256 G protein-coupled glutamate receptor binding 2
## GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 2
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 2
## GO:0046580 negative regulation of Ras protein signal transduction 2
## GO:0008270 zinc ion binding 27
## GO:0001525 angiogenesis 7
## GO:0030155 regulation of cell adhesion 2
## GO:0045176 apical protein localization 2
## GO:0007275 multicellular organism development 20
## GO:0003924 GTPase activity 14c_dn <- enricher(gene = CvG_dn, universe = CvG_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_dn,15)## ID
## GO:0001780 neutrophil homeostasis GO:0001780 neutrophil homeostasis
## GO:0031902 late endosome membrane GO:0031902 late endosome membrane
## GO:0055008 cardiac muscle tissue morphogenesis GO:0055008 cardiac muscle tissue morphogenesis
## GO:0005765 lysosomal membrane GO:0005765 lysosomal membrane
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0008652 cellular amino acid biosynthetic process GO:0008652 cellular amino acid biosynthetic process
## GO:0000123 histone acetyltransferase complex GO:0000123 histone acetyltransferase complex
## GO:0009617 response to bacterium GO:0009617 response to bacterium
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0006325 chromatin organization GO:0006325 chromatin organization
## GO:0002224 toll-like receptor signaling pathway GO:0002224 toll-like receptor signaling pathway
## GO:0000413 protein peptidyl-prolyl isomerization GO:0000413 protein peptidyl-prolyl isomerization
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity GO:0003755 peptidyl-prolyl cis-trans isomerase activity
## GO:0033180 proton-transporting V-type ATPase, V1 domain GO:0033180 proton-transporting V-type ATPase, V1 domain
## Description
## GO:0001780 neutrophil homeostasis GO:0001780 neutrophil homeostasis
## GO:0031902 late endosome membrane GO:0031902 late endosome membrane
## GO:0055008 cardiac muscle tissue morphogenesis GO:0055008 cardiac muscle tissue morphogenesis
## GO:0005765 lysosomal membrane GO:0005765 lysosomal membrane
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0008652 cellular amino acid biosynthetic process GO:0008652 cellular amino acid biosynthetic process
## GO:0000123 histone acetyltransferase complex GO:0000123 histone acetyltransferase complex
## GO:0009617 response to bacterium GO:0009617 response to bacterium
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0006325 chromatin organization GO:0006325 chromatin organization
## GO:0002224 toll-like receptor signaling pathway GO:0002224 toll-like receptor signaling pathway
## GO:0000413 protein peptidyl-prolyl isomerization GO:0000413 protein peptidyl-prolyl isomerization
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity GO:0003755 peptidyl-prolyl cis-trans isomerase activity
## GO:0033180 proton-transporting V-type ATPase, V1 domain GO:0033180 proton-transporting V-type ATPase, V1 domain
## GeneRatio BgRatio
## GO:0001780 neutrophil homeostasis 3/818 5/18074
## GO:0031902 late endosome membrane 6/818 29/18074
## GO:0055008 cardiac muscle tissue morphogenesis 3/818 6/18074
## GO:0005765 lysosomal membrane 8/818 57/18074
## GO:0043087 regulation of GTPase activity 5/818 27/18074
## GO:0003677 DNA binding 69/818 1132/18074
## GO:0008652 cellular amino acid biosynthetic process 4/818 18/18074
## GO:0000123 histone acetyltransferase complex 3/818 10/18074
## GO:0009617 response to bacterium 4/818 19/18074
## GO:0003700 DNA-binding transcription factor activity 32/818 464/18074
## GO:0006325 chromatin organization 9/818 83/18074
## GO:0002224 toll-like receptor signaling pathway 4/818 21/18074
## GO:0000413 protein peptidyl-prolyl isomerization 6/818 44/18074
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/818 44/18074
## GO:0033180 proton-transporting V-type ATPase, V1 domain 3/818 12/18074
## pvalue p.adjust
## GO:0001780 neutrophil homeostasis 0.0008624249 0.4933654
## GO:0031902 late endosome membrane 0.0016389411 0.4933654
## GO:0055008 cardiac muscle tissue morphogenesis 0.0016667751 0.4933654
## GO:0005765 lysosomal membrane 0.0039375794 0.7340555
## GO:0043087 regulation of GTPase activity 0.0066026450 0.7340555
## GO:0003677 DNA binding 0.0070096498 0.7340555
## GO:0008652 cellular amino acid biosynthetic process 0.0076669378 0.7340555
## GO:0000123 histone acetyltransferase complex 0.0087274568 0.7340555
## GO:0009617 response to bacterium 0.0093692959 0.7340555
## GO:0003700 DNA-binding transcription factor activity 0.0121349858 0.7340555
## GO:0006325 chromatin organization 0.0125824691 0.7340555
## GO:0002224 toll-like receptor signaling pathway 0.0134683805 0.7340555
## GO:0000413 protein peptidyl-prolyl isomerization 0.0137289765 0.7340555
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity 0.0137289765 0.7340555
## GO:0033180 proton-transporting V-type ATPase, V1 domain 0.0149546617 0.7340555
## qvalue
## GO:0001780 neutrophil homeostasis 0.4859965
## GO:0031902 late endosome membrane 0.4859965
## GO:0055008 cardiac muscle tissue morphogenesis 0.4859965
## GO:0005765 lysosomal membrane 0.7230917
## GO:0043087 regulation of GTPase activity 0.7230917
## GO:0003677 DNA binding 0.7230917
## GO:0008652 cellular amino acid biosynthetic process 0.7230917
## GO:0000123 histone acetyltransferase complex 0.7230917
## GO:0009617 response to bacterium 0.7230917
## GO:0003700 DNA-binding transcription factor activity 0.7230917
## GO:0006325 chromatin organization 0.7230917
## GO:0002224 toll-like receptor signaling pathway 0.7230917
## GO:0000413 protein peptidyl-prolyl isomerization 0.7230917
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity 0.7230917
## GO:0033180 proton-transporting V-type ATPase, V1 domain 0.7230917
## geneID
## GO:0001780 neutrophil homeostasis ENSPREG00000018748/ENSPREG00000008698/ENSPREG00000020541
## GO:0031902 late endosome membrane ENSPREG00000003165/ENSPREG00000021926/ENSPREG00000017357/ENSPREG00000011724/ENSPREG00000011436/ENSPREG00000020757
## GO:0055008 cardiac muscle tissue morphogenesis ENSPREG00000005618/ENSPREG00000006261/ENSPREG00000001183
## GO:0005765 lysosomal membrane ENSPREG00000003165/ENSPREG00000001947/ENSPREG00000000381/ENSPREG00000016457/ENSPREG00000017357/ENSPREG00000005220/ENSPREG00000005255/ENSPREG00000022384
## GO:0043087 regulation of GTPase activity ENSPREG00000002871/ENSPREG00000014012/ENSPREG00000019661/ENSPREG00000023097/ENSPREG00000017204
## GO:0003677 DNA binding ENSPREG00000018820/ENSPREG00000000557/ENSPREG00000022956/ENSPREG00000004266/ENSPREG00000021021/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000001592/ENSPREG00000018881/ENSPREG00000013623/ENSPREG00000011707/ENSPREG00000014745/ENSPREG00000008785/ENSPREG00000004107/ENSPREG00000018748/ENSPREG00000020394/ENSPREG00000010865/ENSPREG00000012718/ENSPREG00000020332/ENSPREG00000011064/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000022075/ENSPREG00000004581/ENSPREG00000000414/ENSPREG00000013766/ENSPREG00000004023/ENSPREG00000016676/ENSPREG00000018249/ENSPREG00000013315/ENSPREG00000003001/ENSPREG00000011305/ENSPREG00000012367/ENSPREG00000019479/ENSPREG00000021725/ENSPREG00000008043/ENSPREG00000010061/ENSPREG00000014960/ENSPREG00000016918/ENSPREG00000010783/ENSPREG00000008698/ENSPREG00000019423/ENSPREG00000014413/ENSPREG00000002904/ENSPREG00000009851/ENSPREG00000003088/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000013995/ENSPREG00000001598/ENSPREG00000007733/ENSPREG00000018024/ENSPREG00000014215/ENSPREG00000014513/ENSPREG00000013122/ENSPREG00000013775/ENSPREG00000000563/ENSPREG00000022267/ENSPREG00000010797/ENSPREG00000004647/ENSPREG00000001340/ENSPREG00000009470/ENSPREG00000006621/ENSPREG00000012699/ENSPREG00000003063/ENSPREG00000008234/ENSPREG00000013812/ENSPREG00000017475/ENSPREG00000011212
## GO:0008652 cellular amino acid biosynthetic process ENSPREG00000009186/ENSPREG00000013056/ENSPREG00000000435/ENSPREG00000022693
## GO:0000123 histone acetyltransferase complex ENSPREG00000009968/ENSPREG00000015471/ENSPREG00000019647
## GO:0009617 response to bacterium ENSPREG00000008790/ENSPREG00000015117/ENSPREG00000014489/ENSPREG00000020541
## GO:0003700 DNA-binding transcription factor activity ENSPREG00000000557/ENSPREG00000021021/ENSPREG00000019762/ENSPREG00000018881/ENSPREG00000014745/ENSPREG00000008785/ENSPREG00000018748/ENSPREG00000020332/ENSPREG00000011064/ENSPREG00000017582/ENSPREG00000021136/ENSPREG00000013766/ENSPREG00000016676/ENSPREG00000013315/ENSPREG00000012367/ENSPREG00000021725/ENSPREG00000016918/ENSPREG00000008698/ENSPREG00000022983/ENSPREG00000013995/ENSPREG00000001598/ENSPREG00000014513/ENSPREG00000013775/ENSPREG00000000563/ENSPREG00000022267/ENSPREG00000010797/ENSPREG00000004647/ENSPREG00000006621/ENSPREG00000012699/ENSPREG00000003063/ENSPREG00000010086/ENSPREG00000011212
## GO:0006325 chromatin organization ENSPREG00000009968/ENSPREG00000010201/ENSPREG00000005463/ENSPREG00000020811/ENSPREG00000008274/ENSPREG00000004647/ENSPREG00000004390/ENSPREG00000011922/ENSPREG00000019898
## GO:0002224 toll-like receptor signaling pathway ENSPREG00000001890/ENSPREG00000019675/ENSPREG00000002257/ENSPREG00000001297
## GO:0000413 protein peptidyl-prolyl isomerization ENSPREG00000017903/ENSPREG00000018364/ENSPREG00000018430/ENSPREG00000019423/ENSPREG00000010703/ENSPREG00000001551
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity ENSPREG00000017903/ENSPREG00000018364/ENSPREG00000018430/ENSPREG00000019423/ENSPREG00000010703/ENSPREG00000001551
## GO:0033180 proton-transporting V-type ATPase, V1 domain ENSPREG00000022841/ENSPREG00000016458/ENSPREG00000019169
## Count
## GO:0001780 neutrophil homeostasis 3
## GO:0031902 late endosome membrane 6
## GO:0055008 cardiac muscle tissue morphogenesis 3
## GO:0005765 lysosomal membrane 8
## GO:0043087 regulation of GTPase activity 5
## GO:0003677 DNA binding 69
## GO:0008652 cellular amino acid biosynthetic process 4
## GO:0000123 histone acetyltransferase complex 3
## GO:0009617 response to bacterium 4
## GO:0003700 DNA-binding transcription factor activity 32
## GO:0006325 chromatin organization 9
## GO:0002224 toll-like receptor signaling pathway 4
## GO:0000413 protein peptidyl-prolyl isomerization 6
## GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6
## GO:0033180 proton-transporting V-type ATPase, V1 domain 3CvGunion <- union(CvG_up,CvG_dn)
c_union <- enricher(gene = CvGunion, universe = CvG_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_union,15)## ID
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0055008 cardiac muscle tissue morphogenesis GO:0055008 cardiac muscle tissue morphogenesis
## GO:0001780 neutrophil homeostasis GO:0001780 neutrophil homeostasis
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0035479 angioblast cell migration from lateral mesoderm to midline GO:0035479 angioblast cell migration from lateral mesoderm to midline
## GO:0055129 L-proline biosynthetic process GO:0055129 L-proline biosynthetic process
## GO:0015075 ion transmembrane transporter activity GO:0015075 ion transmembrane transporter activity
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GO:0004383 guanylate cyclase activity GO:0004383 guanylate cyclase activity
## GO:0006182 cGMP biosynthetic process GO:0006182 cGMP biosynthetic process
## GO:0071910 determination of liver left/right asymmetry GO:0071910 determination of liver left/right asymmetry
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0010468 regulation of gene expression GO:0010468 regulation of gene expression
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0031902 late endosome membrane GO:0031902 late endosome membrane
## Description
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0055008 cardiac muscle tissue morphogenesis GO:0055008 cardiac muscle tissue morphogenesis
## GO:0001780 neutrophil homeostasis GO:0001780 neutrophil homeostasis
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0035479 angioblast cell migration from lateral mesoderm to midline GO:0035479 angioblast cell migration from lateral mesoderm to midline
## GO:0055129 L-proline biosynthetic process GO:0055129 L-proline biosynthetic process
## GO:0015075 ion transmembrane transporter activity GO:0015075 ion transmembrane transporter activity
## GO:0030155 regulation of cell adhesion GO:0030155 regulation of cell adhesion
## GO:0004383 guanylate cyclase activity GO:0004383 guanylate cyclase activity
## GO:0006182 cGMP biosynthetic process GO:0006182 cGMP biosynthetic process
## GO:0071910 determination of liver left/right asymmetry GO:0071910 determination of liver left/right asymmetry
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0010468 regulation of gene expression GO:0010468 regulation of gene expression
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0031902 late endosome membrane GO:0031902 late endosome membrane
## GeneRatio
## GO:0043087 regulation of GTPase activity 9/1226
## GO:0055008 cardiac muscle tissue morphogenesis 4/1226
## GO:0001780 neutrophil homeostasis 3/1226
## GO:0003677 DNA binding 99/1226
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 3/1226
## GO:0055129 L-proline biosynthetic process 3/1226
## GO:0015075 ion transmembrane transporter activity 3/1226
## GO:0030155 regulation of cell adhesion 3/1226
## GO:0004383 guanylate cyclase activity 4/1226
## GO:0006182 cGMP biosynthetic process 4/1226
## GO:0071910 determination of liver left/right asymmetry 4/1226
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 28/1226
## GO:0010468 regulation of gene expression 7/1226
## GO:0007275 multicellular organism development 46/1226
## GO:0031902 late endosome membrane 6/1226
## BgRatio
## GO:0043087 regulation of GTPase activity 27/18074
## GO:0055008 cardiac muscle tissue morphogenesis 6/18074
## GO:0001780 neutrophil homeostasis 5/18074
## GO:0003677 DNA binding 1132/18074
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 6/18074
## GO:0055129 L-proline biosynthetic process 6/18074
## GO:0015075 ion transmembrane transporter activity 7/18074
## GO:0030155 regulation of cell adhesion 7/18074
## GO:0004383 guanylate cyclase activity 13/18074
## GO:0006182 cGMP biosynthetic process 13/18074
## GO:0071910 determination of liver left/right asymmetry 13/18074
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18074
## GO:0010468 regulation of gene expression 37/18074
## GO:0007275 multicellular organism development 480/18074
## GO:0031902 late endosome membrane 29/18074
## pvalue
## GO:0043087 regulation of GTPase activity 4.525557e-05
## GO:0055008 cardiac muscle tissue morphogenesis 2.828789e-04
## GO:0001780 neutrophil homeostasis 2.806421e-03
## GO:0003677 DNA binding 5.102091e-03
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 5.329963e-03
## GO:0055129 L-proline biosynthetic process 5.329963e-03
## GO:0015075 ion transmembrane transporter activity 8.859052e-03
## GO:0030155 regulation of cell adhesion 8.859052e-03
## GO:0004383 guanylate cyclase activity 9.179574e-03
## GO:0006182 cGMP biosynthetic process 9.179574e-03
## GO:0071910 determination of liver left/right asymmetry 9.179574e-03
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 1.039523e-02
## GO:0010468 regulation of gene expression 1.110295e-02
## GO:0007275 multicellular organism development 1.124933e-02
## GO:0031902 late endosome membrane 1.185465e-02
## p.adjust
## GO:0043087 regulation of GTPase activity 0.04946434
## GO:0055008 cardiac muscle tissue morphogenesis 0.15459334
## GO:0001780 neutrophil homeostasis 0.78896052
## GO:0003677 DNA binding 0.78896052
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.78896052
## GO:0055129 L-proline biosynthetic process 0.78896052
## GO:0015075 ion transmembrane transporter activity 0.78896052
## GO:0030155 regulation of cell adhesion 0.78896052
## GO:0004383 guanylate cyclase activity 0.78896052
## GO:0006182 cGMP biosynthetic process 0.78896052
## GO:0071910 determination of liver left/right asymmetry 0.78896052
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.78896052
## GO:0010468 regulation of gene expression 0.78896052
## GO:0007275 multicellular organism development 0.78896052
## GO:0031902 late endosome membrane 0.78896052
## qvalue
## GO:0043087 regulation of GTPase activity 0.04906657
## GO:0055008 cardiac muscle tissue morphogenesis 0.15335016
## GO:0001780 neutrophil homeostasis 0.78261602
## GO:0003677 DNA binding 0.78261602
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.78261602
## GO:0055129 L-proline biosynthetic process 0.78261602
## GO:0015075 ion transmembrane transporter activity 0.78261602
## GO:0030155 regulation of cell adhesion 0.78261602
## GO:0004383 guanylate cyclase activity 0.78261602
## GO:0006182 cGMP biosynthetic process 0.78261602
## GO:0071910 determination of liver left/right asymmetry 0.78261602
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.78261602
## GO:0010468 regulation of gene expression 0.78261602
## GO:0007275 multicellular organism development 0.78261602
## GO:0031902 late endosome membrane 0.78261602
## geneID
## GO:0043087 regulation of GTPase activity ENSPREG00000017857/ENSPREG00000008324/ENSPREG00000004344/ENSPREG00000021572/ENSPREG00000002871/ENSPREG00000014012/ENSPREG00000019661/ENSPREG00000023097/ENSPREG00000017204
## GO:0055008 cardiac muscle tissue morphogenesis ENSPREG00000007027/ENSPREG00000005618/ENSPREG00000006261/ENSPREG00000001183
## GO:0001780 neutrophil homeostasis ENSPREG00000018748/ENSPREG00000008698/ENSPREG00000020541
## GO:0003677 DNA binding ENSPREG00000001606/ENSPREG00000022182/ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000012138/ENSPREG00000021365/ENSPREG00000009198/ENSPREG00000014369/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000014523/ENSPREG00000012367/ENSPREG00000004029/ENSPREG00000011115/ENSPREG00000012663/ENSPREG00000010341/ENSPREG00000019599/ENSPREG00000006777/ENSPREG00000008233/ENSPREG00000006061/ENSPREG00000019092/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000012965/ENSPREG00000006239/ENSPREG00000022564/ENSPREG00000000237/ENSPREG00000004107/ENSPREG00000006396/ENSPREG00000000142/ENSPREG00000005385/ENSPREG00000012188/ENSPREG00000000557/ENSPREG00000004218/ENSPREG00000018820/ENSPREG00000022956/ENSPREG00000004266/ENSPREG00000021021/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000001592/ENSPREG00000018881/ENSPREG00000013623/ENSPREG00000011707/ENSPREG00000014745/ENSPREG00000008785/ENSPREG00000018748/ENSPREG00000020394/ENSPREG00000010865/ENSPREG00000012718/ENSPREG00000020332/ENSPREG00000011064/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000022075/ENSPREG00000004581/ENSPREG00000000414/ENSPREG00000013766/ENSPREG00000004023/ENSPREG00000016676/ENSPREG00000018249/ENSPREG00000013315/ENSPREG00000003001/ENSPREG00000011305/ENSPREG00000019479/ENSPREG00000008043/ENSPREG00000010061/ENSPREG00000014960/ENSPREG00000016918/ENSPREG00000010783/ENSPREG00000008698/ENSPREG00000019423/ENSPREG00000014413/ENSPREG00000002904/ENSPREG00000009851/ENSPREG00000003088/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000013995/ENSPREG00000001598/ENSPREG00000007733/ENSPREG00000018024/ENSPREG00000014215/ENSPREG00000014513/ENSPREG00000013122/ENSPREG00000013775/ENSPREG00000000563/ENSPREG00000022267/ENSPREG00000010797/ENSPREG00000004647/ENSPREG00000001340/ENSPREG00000009470/ENSPREG00000006621/ENSPREG00000012699/ENSPREG00000003063/ENSPREG00000008234/ENSPREG00000013812/ENSPREG00000017475/ENSPREG00000011212
## GO:0035479 angioblast cell migration from lateral mesoderm to midline ENSPREG00000011756/ENSPREG00000010859/ENSPREG00000010464
## GO:0055129 L-proline biosynthetic process ENSPREG00000006997/ENSPREG00000009186/ENSPREG00000000435
## GO:0015075 ion transmembrane transporter activity ENSPREG00000003778/ENSPREG00000005776/ENSPREG00000007011
## GO:0030155 regulation of cell adhesion ENSPREG00000020191/ENSPREG00000010044/ENSPREG00000021917
## GO:0004383 guanylate cyclase activity ENSPREG00000017233/ENSPREG00000020922/ENSPREG00000002322/ENSPREG00000005428
## GO:0006182 cGMP biosynthetic process ENSPREG00000017233/ENSPREG00000020922/ENSPREG00000002322/ENSPREG00000005428
## GO:0071910 determination of liver left/right asymmetry ENSPREG00000011756/ENSPREG00000010859/ENSPREG00000016753/ENSPREG00000010464
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000009198/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011115/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000006396/ENSPREG00000005385/ENSPREG00000012188/ENSPREG00000002057/ENSPREG00000000557/ENSPREG00000021021/ENSPREG00000021717/ENSPREG00000013623/ENSPREG00000020332/ENSPREG00000021719/ENSPREG00000013766/ENSPREG00000003001/ENSPREG00000010783/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000000563/ENSPREG00000010797/ENSPREG00000001340/ENSPREG00000013812
## GO:0010468 regulation of gene expression ENSPREG00000018405/ENSPREG00000019660/ENSPREG00000011305/ENSPREG00000014413/ENSPREG00000014215/ENSPREG00000006621/ENSPREG00000013812
## GO:0007275 multicellular organism development ENSPREG00000006479/ENSPREG00000004660/ENSPREG00000021420/ENSPREG00000009198/ENSPREG00000014369/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011115/ENSPREG00000010035/ENSPREG00000007669/ENSPREG00000021106/ENSPREG00000011756/ENSPREG00000006777/ENSPREG00000021725/ENSPREG00000020011/ENSPREG00000006396/ENSPREG00000001810/ENSPREG00000005385/ENSPREG00000001804/ENSPREG00000000557/ENSPREG00000000612/ENSPREG00000021322/ENSPREG00000021021/ENSPREG00000021717/ENSPREG00000019762/ENSPREG00000020332/ENSPREG00000017582/ENSPREG00000021719/ENSPREG00000018360/ENSPREG00000013766/ENSPREG00000003001/ENSPREG00000009481/ENSPREG00000016378/ENSPREG00000010783/ENSPREG00000003088/ENSPREG00000022983/ENSPREG00000008377/ENSPREG00000004667/ENSPREG00000009349/ENSPREG00000014773/ENSPREG00000000563/ENSPREG00000010797/ENSPREG00000001340/ENSPREG00000013812/ENSPREG00000017475/ENSPREG00000005101
## GO:0031902 late endosome membrane ENSPREG00000003165/ENSPREG00000021926/ENSPREG00000017357/ENSPREG00000011724/ENSPREG00000011436/ENSPREG00000020757
## Count
## GO:0043087 regulation of GTPase activity 9
## GO:0055008 cardiac muscle tissue morphogenesis 4
## GO:0001780 neutrophil homeostasis 3
## GO:0003677 DNA binding 99
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 3
## GO:0055129 L-proline biosynthetic process 3
## GO:0015075 ion transmembrane transporter activity 3
## GO:0030155 regulation of cell adhesion 3
## GO:0004383 guanylate cyclase activity 4
## GO:0006182 cGMP biosynthetic process 4
## GO:0071910 determination of liver left/right asymmetry 4
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 28
## GO:0010468 regulation of gene expression 7
## GO:0007275 multicellular organism development 46
## GO:0031902 late endosome membrane 6library(reshape2)
CvL_up <- subset(CvL,meth.diff>0&qvalue<0.05)
CvL_up <- unique(CvL_up$gene_id)
str(CvL_up)## chr [1:3018] "ENSPREG00000003617" "ENSPREG00000008406" ...CvL_dn <- subset(CvL,meth.diff<0&qvalue<0.05)
CvL_dn <- unique(CvL_dn$gene_id)
str(CvL_dn)## chr [1:4039] "ENSPREG00000014846" "ENSPREG00000010182" ...CvL_bg <- unique(CvL$gene_id)
str(CvL_bg)## chr [1:21581] "ENSPREG00000014846" "ENSPREG00000003617" ...c_up <- enricher(gene = CvL_up, universe = CvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_up,15)## ID
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0060042 retina morphogenesis in camera-type eye GO:0060042 retina morphogenesis in camera-type eye
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0043401 steroid hormone mediated signaling pathway GO:0043401 steroid hormone mediated signaling pathway
## GO:0045666 positive regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation
## GO:0051382 kinetochore assembly GO:0051382 kinetochore assembly
## GO:0072546 ER membrane protein complex GO:0072546 ER membrane protein complex
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0017154 semaphorin receptor activity GO:0017154 semaphorin receptor activity
## GO:0071526 semaphorin-plexin signaling pathway GO:0071526 semaphorin-plexin signaling pathway
## GO:0060027 convergent extension involved in gastrulation GO:0060027 convergent extension involved in gastrulation
## GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity
## Description
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0060042 retina morphogenesis in camera-type eye GO:0060042 retina morphogenesis in camera-type eye
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0043401 steroid hormone mediated signaling pathway GO:0043401 steroid hormone mediated signaling pathway
## GO:0045666 positive regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation
## GO:0051382 kinetochore assembly GO:0051382 kinetochore assembly
## GO:0072546 ER membrane protein complex GO:0072546 ER membrane protein complex
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0017154 semaphorin receptor activity GO:0017154 semaphorin receptor activity
## GO:0071526 semaphorin-plexin signaling pathway GO:0071526 semaphorin-plexin signaling pathway
## GO:0060027 convergent extension involved in gastrulation GO:0060027 convergent extension involved in gastrulation
## GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity
## GeneRatio
## GO:0005634 nucleus 363/2580
## GO:0060042 retina morphogenesis in camera-type eye 9/2580
## GO:0007275 multicellular organism development 94/2580
## GO:0003700 DNA-binding transcription factor activity 90/2580
## GO:0003677 DNA binding 196/2580
## GO:0006355 regulation of transcription, DNA-templated 155/2580
## GO:0043401 steroid hormone mediated signaling pathway 7/2580
## GO:0045666 positive regulation of neuron differentiation 5/2580
## GO:0051382 kinetochore assembly 4/2580
## GO:0072546 ER membrane protein complex 4/2580
## GO:0005515 protein binding 531/2580
## GO:0017154 semaphorin receptor activity 7/2580
## GO:0071526 semaphorin-plexin signaling pathway 7/2580
## GO:0060027 convergent extension involved in gastrulation 12/2580
## GO:0004715 non-membrane spanning protein tyrosine kinase activity 11/2580
## BgRatio
## GO:0005634 nucleus 2106/18067
## GO:0060042 retina morphogenesis in camera-type eye 19/18067
## GO:0007275 multicellular organism development 480/18067
## GO:0003700 DNA-binding transcription factor activity 463/18067
## GO:0003677 DNA binding 1131/18067
## GO:0006355 regulation of transcription, DNA-templated 875/18067
## GO:0043401 steroid hormone mediated signaling pathway 16/18067
## GO:0045666 positive regulation of neuron differentiation 9/18067
## GO:0051382 kinetochore assembly 6/18067
## GO:0072546 ER membrane protein complex 6/18067
## GO:0005515 protein binding 3391/18067
## GO:0017154 semaphorin receptor activity 17/18067
## GO:0071526 semaphorin-plexin signaling pathway 17/18067
## GO:0060027 convergent extension involved in gastrulation 39/18067
## GO:0004715 non-membrane spanning protein tyrosine kinase activity 35/18067
## pvalue
## GO:0005634 nucleus 3.093726e-05
## GO:0060042 retina morphogenesis in camera-type eye 5.778665e-04
## GO:0007275 multicellular organism development 7.533353e-04
## GO:0003700 DNA-binding transcription factor activity 1.221920e-03
## GO:0003677 DNA binding 1.761198e-03
## GO:0006355 regulation of transcription, DNA-templated 2.156309e-03
## GO:0043401 steroid hormone mediated signaling pathway 4.200775e-03
## GO:0045666 positive regulation of neuron differentiation 4.510716e-03
## GO:0051382 kinetochore assembly 4.889189e-03
## GO:0072546 ER membrane protein complex 4.889189e-03
## GO:0005515 protein binding 6.234231e-03
## GO:0017154 semaphorin receptor activity 6.270641e-03
## GO:0071526 semaphorin-plexin signaling pathway 6.270641e-03
## GO:0060027 convergent extension involved in gastrulation 6.491300e-03
## GO:0004715 non-membrane spanning protein tyrosine kinase activity 7.565802e-03
## p.adjust
## GO:0005634 nucleus 0.04458059
## GO:0060042 retina morphogenesis in camera-type eye 0.36185205
## GO:0007275 multicellular organism development 0.36185205
## GO:0003700 DNA-binding transcription factor activity 0.44019669
## GO:0003677 DNA binding 0.50757738
## GO:0006355 regulation of transcription, DNA-templated 0.51787358
## GO:0043401 steroid hormone mediated signaling pathway 0.62035989
## GO:0045666 positive regulation of neuron differentiation 0.62035989
## GO:0051382 kinetochore assembly 0.62035989
## GO:0072546 ER membrane protein complex 0.62035989
## GO:0005515 protein binding 0.62035989
## GO:0017154 semaphorin receptor activity 0.62035989
## GO:0071526 semaphorin-plexin signaling pathway 0.62035989
## GO:0060027 convergent extension involved in gastrulation 0.62035989
## GO:0004715 non-membrane spanning protein tyrosine kinase activity 0.62035989
## qvalue
## GO:0005634 nucleus 0.04458059
## GO:0060042 retina morphogenesis in camera-type eye 0.36185205
## GO:0007275 multicellular organism development 0.36185205
## GO:0003700 DNA-binding transcription factor activity 0.44019669
## GO:0003677 DNA binding 0.50757738
## GO:0006355 regulation of transcription, DNA-templated 0.51787358
## GO:0043401 steroid hormone mediated signaling pathway 0.62035989
## GO:0045666 positive regulation of neuron differentiation 0.62035989
## GO:0051382 kinetochore assembly 0.62035989
## GO:0072546 ER membrane protein complex 0.62035989
## GO:0005515 protein binding 0.62035989
## GO:0017154 semaphorin receptor activity 0.62035989
## GO:0071526 semaphorin-plexin signaling pathway 0.62035989
## GO:0060027 convergent extension involved in gastrulation 0.62035989
## GO:0004715 non-membrane spanning protein tyrosine kinase activity 0.62035989
## geneID
## GO:0005634 nucleus ENSPREG00000011953/ENSPREG00000021725/ENSPREG00000011868/ENSPREG00000004660/ENSPREG00000014413/ENSPREG00000015451/ENSPREG00000002287/ENSPREG00000011568/ENSPREG00000022114/ENSPREG00000001380/ENSPREG00000012357/ENSPREG00000019101/ENSPREG00000004107/ENSPREG00000001606/ENSPREG00000009351/ENSPREG00000010174/ENSPREG00000022340/ENSPREG00000003434/ENSPREG00000019660/ENSPREG00000012325/ENSPREG00000000312/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000001505/ENSPREG00000007342/ENSPREG00000012367/ENSPREG00000019472/ENSPREG00000018852/ENSPREG00000011799/ENSPREG00000007722/ENSPREG00000002117/ENSPREG00000011856/ENSPREG00000005028/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000008389/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000005482/ENSPREG00000017808/ENSPREG00000010644/ENSPREG00000016347/ENSPREG00000017205/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000016534/ENSPREG00000013639/ENSPREG00000014531/ENSPREG00000016605/ENSPREG00000005993/ENSPREG00000014446/ENSPREG00000013940/ENSPREG00000009394/ENSPREG00000004581/ENSPREG00000018786/ENSPREG00000013384/ENSPREG00000013196/ENSPREG00000012003/ENSPREG00000009984/ENSPREG00000019274/ENSPREG00000017440/ENSPREG00000021982/ENSPREG00000003428/ENSPREG00000015828/ENSPREG00000000447/ENSPREG00000007638/ENSPREG00000003295/ENSPREG00000016437/ENSPREG00000017164/ENSPREG00000001484/ENSPREG00000018613/ENSPREG00000021691/ENSPREG00000003918/ENSPREG00000004218/ENSPREG00000020193/ENSPREG00000008997/ENSPREG00000013067/ENSPREG00000006372/ENSPREG00000009356/ENSPREG00000000386/ENSPREG00000012184/ENSPREG00000003897/ENSPREG00000010797/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000003440/ENSPREG00000002923/ENSPREG00000013896/ENSPREG00000009540/ENSPREG00000022466/ENSPREG00000018024/ENSPREG00000022696/ENSPREG00000022365/ENSPREG00000014049/ENSPREG00000022088/ENSPREG00000016797/ENSPREG00000008456/ENSPREG00000020203/ENSPREG00000012868/ENSPREG00000005038/ENSPREG00000005223/ENSPREG00000007173/ENSPREG00000022277/ENSPREG00000020685/ENSPREG00000016742/ENSPREG00000005527/ENSPREG00000010381/ENSPREG00000014985/ENSPREG00000018023/ENSPREG00000013858/ENSPREG00000016063/ENSPREG00000018405/ENSPREG00000006464/ENSPREG00000018193/ENSPREG00000021362/ENSPREG00000018972/ENSPREG00000014803/ENSPREG00000000378/ENSPREG00000021553/ENSPREG00000003192/ENSPREG00000022267/ENSPREG00000021274/ENSPREG00000017405/ENSPREG00000007784/ENSPREG00000014523/ENSPREG00000005151/ENSPREG00000015738/ENSPREG00000018925/ENSPREG00000003423/ENSPREG00000010877/ENSPREG00000012529/ENSPREG00000018272/ENSPREG00000018746/ENSPREG00000009131/ENSPREG00000002487/ENSPREG00000007244/ENSPREG00000019470/ENSPREG00000012950/ENSPREG00000016198/ENSPREG00000011482/ENSPREG00000012663/ENSPREG00000012105/ENSPREG00000018630/ENSPREG00000008156/ENSPREG00000008418/ENSPREG00000008711/ENSPREG00000005278/ENSPREG00000005000/ENSPREG00000012965/ENSPREG00000017836/ENSPREG00000004058/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000001047/ENSPREG00000021700/ENSPREG00000011942/ENSPREG00000000639/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000015111/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000015315/ENSPREG00000018564/ENSPREG00000000136/ENSPREG00000001369/ENSPREG00000020625/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000003891/ENSPREG00000001598/ENSPREG00000016234/ENSPREG00000006038/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000010135/ENSPREG00000009925/ENSPREG00000015465/ENSPREG00000008666/ENSPREG00000008743/ENSPREG00000011827/ENSPREG00000020416/ENSPREG00000000793/ENSPREG00000015258/ENSPREG00000019319/ENSPREG00000014215/ENSPREG00000008960/ENSPREG00000010768/ENSPREG00000012719/ENSPREG00000020303/ENSPREG00000004213/ENSPREG00000001114/ENSPREG00000000568/ENSPREG00000007804/ENSPREG00000019031/ENSPREG00000013255/ENSPREG00000015981/ENSPREG00000009198/ENSPREG00000018196/ENSPREG00000015905/ENSPREG00000021952/ENSPREG00000008337/ENSPREG00000008276/ENSPREG00000015331/ENSPREG00000006032/ENSPREG00000006079/ENSPREG00000001395/ENSPREG00000014770/ENSPREG00000005288/ENSPREG00000003052/ENSPREG00000020093/ENSPREG00000020466/ENSPREG00000017365/ENSPREG00000002617/ENSPREG00000022194/ENSPREG00000010656/ENSPREG00000002331/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000000644/ENSPREG00000020796/ENSPREG00000021642/ENSPREG00000008761/ENSPREG00000000227/ENSPREG00000021410/ENSPREG00000017378/ENSPREG00000022485/ENSPREG00000002499/ENSPREG00000019694/ENSPREG00000022223/ENSPREG00000006606/ENSPREG00000005818/ENSPREG00000017291/ENSPREG00000009483/ENSPREG00000000662/ENSPREG00000021495/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000004782/ENSPREG00000017370/ENSPREG00000001155/ENSPREG00000021835/ENSPREG00000003285/ENSPREG00000005356/ENSPREG00000003764/ENSPREG00000018923/ENSPREG00000014826/ENSPREG00000020464/ENSPREG00000018565/ENSPREG00000006388/ENSPREG00000011196/ENSPREG00000015751/ENSPREG00000017854/ENSPREG00000015075/ENSPREG00000016109/ENSPREG00000019599/ENSPREG00000015503/ENSPREG00000004835/ENSPREG00000000100/ENSPREG00000001897/ENSPREG00000023206/ENSPREG00000003049/ENSPREG00000000694/ENSPREG00000006242/ENSPREG00000021707/ENSPREG00000007951/ENSPREG00000005599/ENSPREG00000020878/ENSPREG00000021865/ENSPREG00000006212/ENSPREG00000010684/ENSPREG00000022906/ENSPREG00000008235/ENSPREG00000022457/ENSPREG00000011388/ENSPREG00000006460/ENSPREG00000002677/ENSPREG00000001500/ENSPREG00000009177/ENSPREG00000004357/ENSPREG00000001222/ENSPREG00000020471/ENSPREG00000014973/ENSPREG00000013848/ENSPREG00000006544/ENSPREG00000017666/ENSPREG00000010486/ENSPREG00000010954/ENSPREG00000012420/ENSPREG00000006249/ENSPREG00000005374/ENSPREG00000006368/ENSPREG00000005136/ENSPREG00000019859/ENSPREG00000010250/ENSPREG00000018463/ENSPREG00000019898/ENSPREG00000018266/ENSPREG00000019315/ENSPREG00000013651/ENSPREG00000007743/ENSPREG00000007210/ENSPREG00000013766/ENSPREG00000019517/ENSPREG00000018366/ENSPREG00000016210/ENSPREG00000015597/ENSPREG00000005401/ENSPREG00000021784/ENSPREG00000005552/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000020100/ENSPREG00000018675/ENSPREG00000002365/ENSPREG00000013087/ENSPREG00000004757/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000020877/ENSPREG00000004514/ENSPREG00000019394/ENSPREG00000009744/ENSPREG00000021857/ENSPREG00000015884/ENSPREG00000001387/ENSPREG00000004768/ENSPREG00000018793/ENSPREG00000011959/ENSPREG00000004628/ENSPREG00000010182/ENSPREG00000003677/ENSPREG00000015137/ENSPREG00000019858/ENSPREG00000021901/ENSPREG00000008937/ENSPREG00000011707/ENSPREG00000022075/ENSPREG00000016194/ENSPREG00000022711/ENSPREG00000000473/ENSPREG00000010143/ENSPREG00000018761/ENSPREG00000015470/ENSPREG00000020853/ENSPREG00000008500/ENSPREG00000002665/ENSPREG00000008032/ENSPREG00000022924/ENSPREG00000003148/ENSPREG00000017403/ENSPREG00000016149/ENSPREG00000008636/ENSPREG00000022772/ENSPREG00000007026/ENSPREG00000004345/ENSPREG00000001918/ENSPREG00000002123/ENSPREG00000017050/ENSPREG00000008906/ENSPREG00000013887
## GO:0060042 retina morphogenesis in camera-type eye ENSPREG00000011115/ENSPREG00000014551/ENSPREG00000000531/ENSPREG00000014440/ENSPREG00000013611/ENSPREG00000016351/ENSPREG00000002339/ENSPREG00000016542/ENSPREG00000002171
## GO:0007275 multicellular organism development ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000007669/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000002117/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000005482/ENSPREG00000018360/ENSPREG00000016605/ENSPREG00000013196/ENSPREG00000017440/ENSPREG00000011227/ENSPREG00000009356/ENSPREG00000010797/ENSPREG00000019060/ENSPREG00000014049/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000022277/ENSPREG00000019287/ENSPREG00000018739/ENSPREG00000018023/ENSPREG00000015614/ENSPREG00000021144/ENSPREG00000018652/ENSPREG00000021274/ENSPREG00000003423/ENSPREG00000009131/ENSPREG00000012105/ENSPREG00000014369/ENSPREG00000020385/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000021420/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000013601/ENSPREG00000001369/ENSPREG00000004544/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000016234/ENSPREG00000021106/ENSPREG00000006008/ENSPREG00000000612/ENSPREG00000015465/ENSPREG00000021474/ENSPREG00000008357/ENSPREG00000000568/ENSPREG00000017388/ENSPREG00000009198/ENSPREG00000015936/ENSPREG00000015331/ENSPREG00000010656/ENSPREG00000008761/ENSPREG00000006606/ENSPREG00000010035/ENSPREG00000006767/ENSPREG00000016622/ENSPREG00000006388/ENSPREG00000023206/ENSPREG00000006544/ENSPREG00000020667/ENSPREG00000017666/ENSPREG00000008801/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000005136/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000009355/ENSPREG00000014891/ENSPREG00000007139/ENSPREG00000018675/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000015884/ENSPREG00000003313/ENSPREG00000004067/ENSPREG00000015470/ENSPREG00000002598/ENSPREG00000008500/ENSPREG00000019995/ENSPREG00000001918/ENSPREG00000002123/ENSPREG00000014903/ENSPREG00000021010
## GO:0003700 DNA-binding transcription factor activity ENSPREG00000021725/ENSPREG00000009351/ENSPREG00000010341/ENSPREG00000012168/ENSPREG00000012367/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000014446/ENSPREG00000012003/ENSPREG00000021982/ENSPREG00000016437/ENSPREG00000013067/ENSPREG00000009356/ENSPREG00000010797/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000009540/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000005038/ENSPREG00000014985/ENSPREG00000018193/ENSPREG00000014803/ENSPREG00000021553/ENSPREG00000022267/ENSPREG00000018746/ENSPREG00000002487/ENSPREG00000009502/ENSPREG00000012663/ENSPREG00000012965/ENSPREG00000014392/ENSPREG00000011942/ENSPREG00000013403/ENSPREG00000011496/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000020625/ENSPREG00000006796/ENSPREG00000001598/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000000512/ENSPREG00000015465/ENSPREG00000000568/ENSPREG00000015905/ENSPREG00000015331/ENSPREG00000001395/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000008761/ENSPREG00000005818/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000001199/ENSPREG00000014826/ENSPREG00000018565/ENSPREG00000016109/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000019842/ENSPREG00000001222/ENSPREG00000006368/ENSPREG00000005136/ENSPREG00000019859/ENSPREG00000013651/ENSPREG00000013766/ENSPREG00000016210/ENSPREG00000015597/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000011725/ENSPREG00000013087/ENSPREG00000021303/ENSPREG00000004757/ENSPREG00000006777/ENSPREG00000004514/ENSPREG00000019394/ENSPREG00000004768/ENSPREG00000004628/ENSPREG00000010182/ENSPREG00000023255/ENSPREG00000016149/ENSPREG00000022772
## GO:0003677 DNA binding ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000014413/ENSPREG00000004595/ENSPREG00000001380/ENSPREG00000019101/ENSPREG00000004107/ENSPREG00000001606/ENSPREG00000009351/ENSPREG00000010174/ENSPREG00000010341/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000012367/ENSPREG00000002117/ENSPREG00000006450/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000015529/ENSPREG00000015289/ENSPREG00000012188/ENSPREG00000016605/ENSPREG00000005993/ENSPREG00000014446/ENSPREG00000013213/ENSPREG00000004581/ENSPREG00000018786/ENSPREG00000011157/ENSPREG00000013196/ENSPREG00000015341/ENSPREG00000012003/ENSPREG00000010940/ENSPREG00000017440/ENSPREG00000003428/ENSPREG00000016437/ENSPREG00000017164/ENSPREG00000021691/ENSPREG00000004218/ENSPREG00000007733/ENSPREG00000013067/ENSPREG00000015542/ENSPREG00000009356/ENSPREG00000012184/ENSPREG00000003897/ENSPREG00000008234/ENSPREG00000010797/ENSPREG00000012547/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000002923/ENSPREG00000018024/ENSPREG00000007643/ENSPREG00000014049/ENSPREG00000022088/ENSPREG00000022317/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000005038/ENSPREG00000022277/ENSPREG00000014985/ENSPREG00000018023/ENSPREG00000018193/ENSPREG00000014803/ENSPREG00000021553/ENSPREG00000022267/ENSPREG00000021274/ENSPREG00000014523/ENSPREG00000015738/ENSPREG00000003423/ENSPREG00000019519/ENSPREG00000018746/ENSPREG00000009131/ENSPREG00000002487/ENSPREG00000012950/ENSPREG00000016198/ENSPREG00000012663/ENSPREG00000012105/ENSPREG00000008418/ENSPREG00000014369/ENSPREG00000012965/ENSPREG00000017553/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000008402/ENSPREG00000011942/ENSPREG00000021669/ENSPREG00000011496/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000001369/ENSPREG00000020625/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000001598/ENSPREG00000021365/ENSPREG00000016234/ENSPREG00000006061/ENSPREG00000003558/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000009925/ENSPREG00000015465/ENSPREG00000008666/ENSPREG00000015395/ENSPREG00000014215/ENSPREG00000001114/ENSPREG00000021474/ENSPREG00000000568/ENSPREG00000012765/ENSPREG00000009198/ENSPREG00000015905/ENSPREG00000008337/ENSPREG00000012389/ENSPREG00000015331/ENSPREG00000001395/ENSPREG00000014770/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000012499/ENSPREG00000017365/ENSPREG00000022194/ENSPREG00000010656/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000021586/ENSPREG00000000644/ENSPREG00000008761/ENSPREG00000006077/ENSPREG00000000227/ENSPREG00000021410/ENSPREG00000006606/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000001756/ENSPREG00000001199/ENSPREG00000017524/ENSPREG00000014826/ENSPREG00000017740/ENSPREG00000018565/ENSPREG00000006388/ENSPREG00000016109/ENSPREG00000019599/ENSPREG00000023206/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000022457/ENSPREG00000006460/ENSPREG00000022930/ENSPREG00000017666/ENSPREG00000010486/ENSPREG00000010954/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000006368/ENSPREG00000005136/ENSPREG00000019859/ENSPREG00000010250/ENSPREG00000013651/ENSPREG00000013766/ENSPREG00000015597/ENSPREG00000014774/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000002365/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000020877/ENSPREG00000004514/ENSPREG00000015884/ENSPREG00000004768/ENSPREG00000004628/ENSPREG00000023255/ENSPREG00000010865/ENSPREG00000011707/ENSPREG00000022075/ENSPREG00000018761/ENSPREG00000015470/ENSPREG00000020876/ENSPREG00000020281/ENSPREG00000008500/ENSPREG00000022924/ENSPREG00000000237/ENSPREG00000016149/ENSPREG00000008636/ENSPREG00000022772/ENSPREG00000002123/ENSPREG00000017050
## GO:0006355 regulation of transcription, DNA-templated ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000009351/ENSPREG00000010804/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000012367/ENSPREG00000002117/ENSPREG00000005028/ENSPREG00000006450/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000014446/ENSPREG00000013196/ENSPREG00000012003/ENSPREG00000018974/ENSPREG00000017440/ENSPREG00000021982/ENSPREG00000003428/ENSPREG00000016437/ENSPREG00000018613/ENSPREG00000003918/ENSPREG00000008997/ENSPREG00000013067/ENSPREG00000015542/ENSPREG00000009356/ENSPREG00000010797/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000003440/ENSPREG00000009540/ENSPREG00000022365/ENSPREG00000014049/ENSPREG00000022317/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000005038/ENSPREG00000014985/ENSPREG00000018023/ENSPREG00000018193/ENSPREG00000021630/ENSPREG00000021362/ENSPREG00000014803/ENSPREG00000021553/ENSPREG00000022267/ENSPREG00000010581/ENSPREG00000007784/ENSPREG00000018925/ENSPREG00000003423/ENSPREG00000010877/ENSPREG00000019519/ENSPREG00000018746/ENSPREG00000009131/ENSPREG00000002487/ENSPREG00000012663/ENSPREG00000012105/ENSPREG00000012965/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000014392/ENSPREG00000008402/ENSPREG00000011942/ENSPREG00000013403/ENSPREG00000011496/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000020625/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000001598/ENSPREG00000021365/ENSPREG00000016234/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000000512/ENSPREG00000015465/ENSPREG00000015395/ENSPREG00000000568/ENSPREG00000015981/ENSPREG00000009198/ENSPREG00000018196/ENSPREG00000015905/ENSPREG00000008337/ENSPREG00000015331/ENSPREG00000001395/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000017365/ENSPREG00000010656/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000000644/ENSPREG00000008761/ENSPREG00000006606/ENSPREG00000005818/ENSPREG00000000662/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000021835/ENSPREG00000005356/ENSPREG00000001199/ENSPREG00000014826/ENSPREG00000018565/ENSPREG00000006388/ENSPREG00000016109/ENSPREG00000023206/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000022457/ENSPREG00000019842/ENSPREG00000001222/ENSPREG00000013848/ENSPREG00000006544/ENSPREG00000017666/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000006368/ENSPREG00000019859/ENSPREG00000010250/ENSPREG00000013651/ENSPREG00000013766/ENSPREG00000018366/ENSPREG00000016210/ENSPREG00000015597/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000013087/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000004514/ENSPREG00000015884/ENSPREG00000004768/ENSPREG00000011959/ENSPREG00000004628/ENSPREG00000010182/ENSPREG00000023255/ENSPREG00000015470/ENSPREG00000020853/ENSPREG00000008500/ENSPREG00000016149/ENSPREG00000022772/ENSPREG00000018399/ENSPREG00000002123
## GO:0043401 steroid hormone mediated signaling pathway ENSPREG00000009351/ENSPREG00000008256/ENSPREG00000002487/ENSPREG00000011942/ENSPREG00000010895/ENSPREG00000000644/ENSPREG00000016149
## GO:0045666 positive regulation of neuron differentiation ENSPREG00000005560/ENSPREG00000020797/ENSPREG00000010498/ENSPREG00000015303/ENSPREG00000019394
## GO:0051382 kinetochore assembly ENSPREG00000012547/ENSPREG00000003052/ENSPREG00000013147/ENSPREG00000004357
## GO:0072546 ER membrane protein complex ENSPREG00000006818/ENSPREG00000015075/ENSPREG00000017366/ENSPREG00000022652
## GO:0005515 protein binding ENSPREG00000011953/ENSPREG00000003585/ENSPREG00000012853/ENSPREG00000004055/ENSPREG00000006443/ENSPREG00000020958/ENSPREG00000000164/ENSPREG00000002278/ENSPREG00000010544/ENSPREG00000001363/ENSPREG00000022961/ENSPREG00000002771/ENSPREG00000019101/ENSPREG00000016965/ENSPREG00000010341/ENSPREG00000000900/ENSPREG00000001335/ENSPREG00000000954/ENSPREG00000000312/ENSPREG00000007731/ENSPREG00000017981/ENSPREG00000019186/ENSPREG00000010064/ENSPREG00000017574/ENSPREG00000002476/ENSPREG00000021756/ENSPREG00000006662/ENSPREG00000017062/ENSPREG00000005051/ENSPREG00000022512/ENSPREG00000021269/ENSPREG00000017111/ENSPREG00000012251/ENSPREG00000006194/ENSPREG00000010675/ENSPREG00000003508/ENSPREG00000002457/ENSPREG00000018360/ENSPREG00000007359/ENSPREG00000010264/ENSPREG00000001755/ENSPREG00000022133/ENSPREG00000011250/ENSPREG00000009749/ENSPREG00000012218/ENSPREG00000008576/ENSPREG00000012822/ENSPREG00000022786/ENSPREG00000005421/ENSPREG00000015185/ENSPREG00000021217/ENSPREG00000016656/ENSPREG00000007748/ENSPREG00000004777/ENSPREG00000008770/ENSPREG00000022184/ENSPREG00000012394/ENSPREG00000009526/ENSPREG00000004054/ENSPREG00000020009/ENSPREG00000006259/ENSPREG00000004210/ENSPREG00000001857/ENSPREG00000016455/ENSPREG00000016460/ENSPREG00000010850/ENSPREG00000004636/ENSPREG00000006420/ENSPREG00000007238/ENSPREG00000005549/ENSPREG00000022326/ENSPREG00000022339/ENSPREG00000009984/ENSPREG00000006436/ENSPREG00000008019/ENSPREG00000004557/ENSPREG00000015324/ENSPREG00000018900/ENSPREG00000010906/ENSPREG00000003283/ENSPREG00000009016/ENSPREG00000023140/ENSPREG00000017454/ENSPREG00000021256/ENSPREG00000010905/ENSPREG00000005048/ENSPREG00000017448/ENSPREG00000009775/ENSPREG00000014023/ENSPREG00000003639/ENSPREG00000019504/ENSPREG00000020820/ENSPREG00000007778/ENSPREG00000008779/ENSPREG00000001445/ENSPREG00000009816/ENSPREG00000019197/ENSPREG00000001908/ENSPREG00000009568/ENSPREG00000011786/ENSPREG00000018613/ENSPREG00000021359/ENSPREG00000001707/ENSPREG00000014502/ENSPREG00000018480/ENSPREG00000003918/ENSPREG00000013331/ENSPREG00000015652/ENSPREG00000021494/ENSPREG00000018963/ENSPREG00000000685/ENSPREG00000011284/ENSPREG00000017061/ENSPREG00000006987/ENSPREG00000011331/ENSPREG00000003791/ENSPREG00000006498/ENSPREG00000013511/ENSPREG00000009287/ENSPREG00000020745/ENSPREG00000008863/ENSPREG00000014625/ENSPREG00000014332/ENSPREG00000008038/ENSPREG00000020473/ENSPREG00000022076/ENSPREG00000001939/ENSPREG00000022874/ENSPREG00000000609/ENSPREG00000012617/ENSPREG00000018667/ENSPREG00000004060/ENSPREG00000009991/ENSPREG00000012897/ENSPREG00000020768/ENSPREG00000000778/ENSPREG00000013339/ENSPREG00000016039/ENSPREG00000020999/ENSPREG00000013249/ENSPREG00000006035/ENSPREG00000022557/ENSPREG00000016525/ENSPREG00000022193/ENSPREG00000016649/ENSPREG00000016742/ENSPREG00000020310/ENSPREG00000019287/ENSPREG00000008034/ENSPREG00000020020/ENSPREG00000020573/ENSPREG00000018579/ENSPREG00000006914/ENSPREG00000018739/ENSPREG00000021915/ENSPREG00000009226/ENSPREG00000020590/ENSPREG00000003437/ENSPREG00000013858/ENSPREG00000001868/ENSPREG00000008052/ENSPREG00000017326/ENSPREG00000016063/ENSPREG00000009689/ENSPREG00000018193/ENSPREG00000017413/ENSPREG00000015614/ENSPREG00000008848/ENSPREG00000004374/ENSPREG00000009970/ENSPREG00000000119/ENSPREG00000021215/ENSPREG00000011322/ENSPREG00000006634/ENSPREG00000016838/ENSPREG00000004773/ENSPREG00000002585/ENSPREG00000012167/ENSPREG00000021481/ENSPREG00000014507/ENSPREG00000019656/ENSPREG00000018652/ENSPREG00000019132/ENSPREG00000010109/ENSPREG00000002194/ENSPREG00000018925/ENSPREG00000022191/ENSPREG00000010877/ENSPREG00000004259/ENSPREG00000017070/ENSPREG00000001142/ENSPREG00000004300/ENSPREG00000010225/ENSPREG00000010503/ENSPREG00000013653/ENSPREG00000005178/ENSPREG00000018468/ENSPREG00000014793/ENSPREG00000015578/ENSPREG00000017867/ENSPREG00000022029/ENSPREG00000018630/ENSPREG00000003604/ENSPREG00000002248/ENSPREG00000000125/ENSPREG00000020067/ENSPREG00000002348/ENSPREG00000017042/ENSPREG00000013496/ENSPREG00000012534/ENSPREG00000010160/ENSPREG00000021797/ENSPREG00000013675/ENSPREG00000015865/ENSPREG00000007974/ENSPREG00000019086/ENSPREG00000006294/ENSPREG00000014092/ENSPREG00000006797/ENSPREG00000007324/ENSPREG00000013327/ENSPREG00000010833/ENSPREG00000016362/ENSPREG00000004312/ENSPREG00000022420/ENSPREG00000012550/ENSPREG00000022289/ENSPREG00000016312/ENSPREG00000020729/ENSPREG00000002145/ENSPREG00000019855/ENSPREG00000001211/ENSPREG00000007903/ENSPREG00000004039/ENSPREG00000003645/ENSPREG00000016756/ENSPREG00000015315/ENSPREG00000020923/ENSPREG00000019248/ENSPREG00000022372/ENSPREG00000017615/ENSPREG00000013611/ENSPREG00000003891/ENSPREG00000015801/ENSPREG00000003542/ENSPREG00000021106/ENSPREG00000003558/ENSPREG00000010978/ENSPREG00000004149/ENSPREG00000017179/ENSPREG00000008818/ENSPREG00000014516/ENSPREG00000006673/ENSPREG00000010595/ENSPREG00000015791/ENSPREG00000006962/ENSPREG00000021539/ENSPREG00000010337/ENSPREG00000001779/ENSPREG00000007565/ENSPREG00000007331/ENSPREG00000014483/ENSPREG00000007218/ENSPREG00000021575/ENSPREG00000005611/ENSPREG00000000341/ENSPREG00000000779/ENSPREG00000017751/ENSPREG00000018891/ENSPREG00000017444/ENSPREG00000002366/ENSPREG00000015258/ENSPREG00000019319/ENSPREG00000011127/ENSPREG00000016459/ENSPREG00000012958/ENSPREG00000000598/ENSPREG00000007319/ENSPREG00000000130/ENSPREG00000018168/ENSPREG00000023130/ENSPREG00000003538/ENSPREG00000010253/ENSPREG00000009748/ENSPREG00000018357/ENSPREG00000020450/ENSPREG00000002792/ENSPREG00000003800/ENSPREG00000016483/ENSPREG00000006438/ENSPREG00000012231/ENSPREG00000016682/ENSPREG00000018477/ENSPREG00000000498/ENSPREG00000017820/ENSPREG00000012402/ENSPREG00000015306/ENSPREG00000003789/ENSPREG00000007632/ENSPREG00000002536/ENSPREG00000007006/ENSPREG00000015905/ENSPREG00000022828/ENSPREG00000001070/ENSPREG00000013271/ENSPREG00000006403/ENSPREG00000004343/ENSPREG00000020515/ENSPREG00000012225/ENSPREG00000013733/ENSPREG00000017328/ENSPREG00000014807/ENSPREG00000016967/ENSPREG00000013044/ENSPREG00000019090/ENSPREG00000004228/ENSPREG00000022838/ENSPREG00000019860/ENSPREG00000003161/ENSPREG00000018661/ENSPREG00000017365/ENSPREG00000019790/ENSPREG00000002917/ENSPREG00000019982/ENSPREG00000000629/ENSPREG00000006781/ENSPREG00000003290/ENSPREG00000020137/ENSPREG00000002735/ENSPREG00000018854/ENSPREG00000007262/ENSPREG00000004021/ENSPREG00000000588/ENSPREG00000000485/ENSPREG00000004632/ENSPREG00000019282/ENSPREG00000017951/ENSPREG00000020325/ENSPREG00000010697/ENSPREG00000009084/ENSPREG00000016523/ENSPREG00000008775/ENSPREG00000008786/ENSPREG00000007493/ENSPREG00000005420/ENSPREG00000022223/ENSPREG00000003169/ENSPREG00000009811/ENSPREG00000002766/ENSPREG00000022877/ENSPREG00000013687/ENSPREG00000018567/ENSPREG00000018440/ENSPREG00000008123/ENSPREG00000016650/ENSPREG00000016750/ENSPREG00000018609/ENSPREG00000020959/ENSPREG00000001407/ENSPREG00000019707/ENSPREG00000007789/ENSPREG00000009060/ENSPREG00000021856/ENSPREG00000020680/ENSPREG00000009420/ENSPREG00000018413/ENSPREG00000010270/ENSPREG00000014937/ENSPREG00000018664/ENSPREG00000010883/ENSPREG00000015764/ENSPREG00000018397/ENSPREG00000014672/ENSPREG00000007053/ENSPREG00000011196/ENSPREG00000015338/ENSPREG00000013074/ENSPREG00000020439/ENSPREG00000015075/ENSPREG00000019585/ENSPREG00000015346/ENSPREG00000016331/ENSPREG00000001436/ENSPREG00000011068/ENSPREG00000006820/ENSPREG00000001060/ENSPREG00000011431/ENSPREG00000011949/ENSPREG00000021865/ENSPREG00000012273/ENSPREG00000002972/ENSPREG00000014047/ENSPREG00000004576/ENSPREG00000006212/ENSPREG00000021455/ENSPREG00000022197/ENSPREG00000021205/ENSPREG00000022224/ENSPREG00000010089/ENSPREG00000001752/ENSPREG00000003965/ENSPREG00000002677/ENSPREG00000001500/ENSPREG00000009177/ENSPREG00000020822/ENSPREG00000008369/ENSPREG00000014973/ENSPREG00000018382/ENSPREG00000001103/ENSPREG00000002254/ENSPREG00000018823/ENSPREG00000006544/ENSPREG00000017366/ENSPREG00000010853/ENSPREG00000010858/ENSPREG00000022805/ENSPREG00000010817/ENSPREG00000011132/ENSPREG00000006025/ENSPREG00000005148/ENSPREG00000019039/ENSPREG00000005192/ENSPREG00000022668/ENSPREG00000013763/ENSPREG00000018266/ENSPREG00000017085/ENSPREG00000017018/ENSPREG00000015714/ENSPREG00000016542/ENSPREG00000001716/ENSPREG00000010039/ENSPREG00000012552/ENSPREG00000003515/ENSPREG00000014312/ENSPREG00000020669/ENSPREG00000018452/ENSPREG00000012989/ENSPREG00000018366/ENSPREG00000021218/ENSPREG00000015597/ENSPREG00000018361/ENSPREG00000014068/ENSPREG00000000638/ENSPREG00000000041/ENSPREG00000018926/ENSPREG00000006387/ENSPREG00000021765/ENSPREG00000011036/ENSPREG00000007582/ENSPREG00000002613/ENSPREG00000014065/ENSPREG00000009142/ENSPREG00000021158/ENSPREG00000007156/ENSPREG00000016621/ENSPREG00000018675/ENSPREG00000021550/ENSPREG00000022746/ENSPREG00000015956/ENSPREG00000004073/ENSPREG00000016118/ENSPREG00000018291/ENSPREG00000005026/ENSPREG00000006669/ENSPREG00000023229/ENSPREG00000023230/ENSPREG00000010400/ENSPREG00000021766/ENSPREG00000019394/ENSPREG00000005952/ENSPREG00000018173/ENSPREG00000011959/ENSPREG00000011957/ENSPREG00000010712/ENSPREG00000002171/ENSPREG00000003313/ENSPREG00000000688/ENSPREG00000001809/ENSPREG00000008648/ENSPREG00000004565/ENSPREG00000010345/ENSPREG00000005875/ENSPREG00000003677/ENSPREG00000018877/ENSPREG00000014041/ENSPREG00000018764/ENSPREG00000019858/ENSPREG00000017741/ENSPREG00000023155/ENSPREG00000001257/ENSPREG00000004963/ENSPREG00000021439/ENSPREG00000022257/ENSPREG00000023048/ENSPREG00000021901/ENSPREG00000003852/ENSPREG00000000473/ENSPREG00000009614/ENSPREG00000022808/ENSPREG00000011946/ENSPREG00000004067/ENSPREG00000018109/ENSPREG00000004566/ENSPREG00000011365/ENSPREG00000019135/ENSPREG00000015843/ENSPREG00000012147/ENSPREG00000021731/ENSPREG00000002598/ENSPREG00000022344/ENSPREG00000010201/ENSPREG00000000237/ENSPREG00000008086/ENSPREG00000009992/ENSPREG00000010914/ENSPREG00000022132/ENSPREG00000004587/ENSPREG00000011776/ENSPREG00000000802/ENSPREG00000000860/ENSPREG00000002240/ENSPREG00000021179/ENSPREG00000021917/ENSPREG00000001918/ENSPREG00000003732/ENSPREG00000001091/ENSPREG00000014903/ENSPREG00000018329/ENSPREG00000015691/ENSPREG00000021634/ENSPREG00000021653
## GO:0017154 semaphorin receptor activity ENSPREG00000013675/ENSPREG00000001211/ENSPREG00000006008/ENSPREG00000002766/ENSPREG00000010035/ENSPREG00000018664/ENSPREG00000015966
## GO:0071526 semaphorin-plexin signaling pathway ENSPREG00000013675/ENSPREG00000001211/ENSPREG00000006008/ENSPREG00000002766/ENSPREG00000010035/ENSPREG00000018664/ENSPREG00000015966
## GO:0060027 convergent extension involved in gastrulation ENSPREG00000018568/ENSPREG00000015009/ENSPREG00000004039/ENSPREG00000006673/ENSPREG00000016583/ENSPREG00000020402/ENSPREG00000015764/ENSPREG00000004863/ENSPREG00000014312/ENSPREG00000020669/ENSPREG00000011843/ENSPREG00000000860
## GO:0004715 non-membrane spanning protein tyrosine kinase activity ENSPREG00000001857/ENSPREG00000004058/ENSPREG00000019336/ENSPREG00000009040/ENSPREG00000013973/ENSPREG00000008419/ENSPREG00000006673/ENSPREG00000007632/ENSPREG00000011543/ENSPREG00000014312/ENSPREG00000018109
## Count
## GO:0005634 nucleus 363
## GO:0060042 retina morphogenesis in camera-type eye 9
## GO:0007275 multicellular organism development 94
## GO:0003700 DNA-binding transcription factor activity 90
## GO:0003677 DNA binding 196
## GO:0006355 regulation of transcription, DNA-templated 155
## GO:0043401 steroid hormone mediated signaling pathway 7
## GO:0045666 positive regulation of neuron differentiation 5
## GO:0051382 kinetochore assembly 4
## GO:0072546 ER membrane protein complex 4
## GO:0005515 protein binding 531
## GO:0017154 semaphorin receptor activity 7
## GO:0071526 semaphorin-plexin signaling pathway 7
## GO:0060027 convergent extension involved in gastrulation 12
## GO:0004715 non-membrane spanning protein tyrosine kinase activity 11c_dn <- enricher(gene = CvL_dn, universe = CvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_dn,15)## ID
## GO:0043565 sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0015075 ion transmembrane transporter activity GO:0015075 ion transmembrane transporter activity
## GO:0004340 glucokinase activity GO:0004340 glucokinase activity
## GO:0051156 glucose 6-phosphate metabolic process GO:0051156 glucose 6-phosphate metabolic process
## GO:0060322 head development GO:0060322 head development
## GO:0004000 adenosine deaminase activity GO:0004000 adenosine deaminase activity
## GO:0030513 positive regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway
## GO:0031017 exocrine pancreas development GO:0031017 exocrine pancreas development
## GO:0051056 regulation of small GTPase mediated signal transduction GO:0051056 regulation of small GTPase mediated signal transduction
## GO:0007062 sister chromatid cohesion GO:0007062 sister chromatid cohesion
## GO:0030111 regulation of Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway
## GO:0060729 intestinal epithelial structure maintenance GO:0060729 intestinal epithelial structure maintenance
## GO:0001678 cellular glucose homeostasis GO:0001678 cellular glucose homeostasis
## GO:0004396 hexokinase activity GO:0004396 hexokinase activity
## Description
## GO:0043565 sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0015075 ion transmembrane transporter activity GO:0015075 ion transmembrane transporter activity
## GO:0004340 glucokinase activity GO:0004340 glucokinase activity
## GO:0051156 glucose 6-phosphate metabolic process GO:0051156 glucose 6-phosphate metabolic process
## GO:0060322 head development GO:0060322 head development
## GO:0004000 adenosine deaminase activity GO:0004000 adenosine deaminase activity
## GO:0030513 positive regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway
## GO:0031017 exocrine pancreas development GO:0031017 exocrine pancreas development
## GO:0051056 regulation of small GTPase mediated signal transduction GO:0051056 regulation of small GTPase mediated signal transduction
## GO:0007062 sister chromatid cohesion GO:0007062 sister chromatid cohesion
## GO:0030111 regulation of Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway
## GO:0060729 intestinal epithelial structure maintenance GO:0060729 intestinal epithelial structure maintenance
## GO:0001678 cellular glucose homeostasis GO:0001678 cellular glucose homeostasis
## GO:0004396 hexokinase activity GO:0004396 hexokinase activity
## GeneRatio
## GO:0043565 sequence-specific DNA binding 60/3404
## GO:0003677 DNA binding 250/3404
## GO:0015075 ion transmembrane transporter activity 5/3404
## GO:0004340 glucokinase activity 5/3404
## GO:0051156 glucose 6-phosphate metabolic process 5/3404
## GO:0060322 head development 5/3404
## GO:0004000 adenosine deaminase activity 6/3404
## GO:0030513 positive regulation of BMP signaling pathway 6/3404
## GO:0031017 exocrine pancreas development 12/3404
## GO:0051056 regulation of small GTPase mediated signal transduction 8/3404
## GO:0007062 sister chromatid cohesion 4/3404
## GO:0030111 regulation of Wnt signaling pathway 4/3404
## GO:0060729 intestinal epithelial structure maintenance 4/3404
## GO:0001678 cellular glucose homeostasis 5/3404
## GO:0004396 hexokinase activity 5/3404
## BgRatio
## GO:0043565 sequence-specific DNA binding 221/18067
## GO:0003677 DNA binding 1131/18067
## GO:0015075 ion transmembrane transporter activity 7/18067
## GO:0004340 glucokinase activity 8/18067
## GO:0051156 glucose 6-phosphate metabolic process 8/18067
## GO:0060322 head development 8/18067
## GO:0004000 adenosine deaminase activity 11/18067
## GO:0030513 positive regulation of BMP signaling pathway 11/18067
## GO:0031017 exocrine pancreas development 32/18067
## GO:0051056 regulation of small GTPase mediated signal transduction 18/18067
## GO:0007062 sister chromatid cohesion 6/18067
## GO:0030111 regulation of Wnt signaling pathway 6/18067
## GO:0060729 intestinal epithelial structure maintenance 6/18067
## GO:0001678 cellular glucose homeostasis 9/18067
## GO:0004396 hexokinase activity 9/18067
## pvalue
## GO:0043565 sequence-specific DNA binding 0.001501922
## GO:0003677 DNA binding 0.002459385
## GO:0015075 ion transmembrane transporter activity 0.003539694
## GO:0004340 glucokinase activity 0.007974799
## GO:0051156 glucose 6-phosphate metabolic process 0.007974799
## GO:0060322 head development 0.007974799
## GO:0004000 adenosine deaminase activity 0.008615010
## GO:0030513 positive regulation of BMP signaling pathway 0.008615010
## GO:0031017 exocrine pancreas development 0.010430044
## GO:0051056 regulation of small GTPase mediated signal transduction 0.011353242
## GO:0007062 sister chromatid cohesion 0.013636079
## GO:0030111 regulation of Wnt signaling pathway 0.013636079
## GO:0060729 intestinal epithelial structure maintenance 0.013636079
## GO:0001678 cellular glucose homeostasis 0.015175489
## GO:0004396 hexokinase activity 0.015175489
## p.adjust
## GO:0043565 sequence-specific DNA binding 0.9587427
## GO:0003677 DNA binding 0.9587427
## GO:0015075 ion transmembrane transporter activity 0.9587427
## GO:0004340 glucokinase activity 0.9587427
## GO:0051156 glucose 6-phosphate metabolic process 0.9587427
## GO:0060322 head development 0.9587427
## GO:0004000 adenosine deaminase activity 0.9587427
## GO:0030513 positive regulation of BMP signaling pathway 0.9587427
## GO:0031017 exocrine pancreas development 0.9587427
## GO:0051056 regulation of small GTPase mediated signal transduction 0.9587427
## GO:0007062 sister chromatid cohesion 0.9587427
## GO:0030111 regulation of Wnt signaling pathway 0.9587427
## GO:0060729 intestinal epithelial structure maintenance 0.9587427
## GO:0001678 cellular glucose homeostasis 0.9587427
## GO:0004396 hexokinase activity 0.9587427
## qvalue
## GO:0043565 sequence-specific DNA binding 0.9587427
## GO:0003677 DNA binding 0.9587427
## GO:0015075 ion transmembrane transporter activity 0.9587427
## GO:0004340 glucokinase activity 0.9587427
## GO:0051156 glucose 6-phosphate metabolic process 0.9587427
## GO:0060322 head development 0.9587427
## GO:0004000 adenosine deaminase activity 0.9587427
## GO:0030513 positive regulation of BMP signaling pathway 0.9587427
## GO:0031017 exocrine pancreas development 0.9587427
## GO:0051056 regulation of small GTPase mediated signal transduction 0.9587427
## GO:0007062 sister chromatid cohesion 0.9587427
## GO:0030111 regulation of Wnt signaling pathway 0.9587427
## GO:0060729 intestinal epithelial structure maintenance 0.9587427
## GO:0001678 cellular glucose homeostasis 0.9587427
## GO:0004396 hexokinase activity 0.9587427
## geneID
## GO:0043565 sequence-specific DNA binding ENSPREG00000003481/ENSPREG00000015916/ENSPREG00000014745/ENSPREG00000013420/ENSPREG00000018748/ENSPREG00000015213/ENSPREG00000014440/ENSPREG00000013694/ENSPREG00000013209/ENSPREG00000013455/ENSPREG00000018565/ENSPREG00000005288/ENSPREG00000008785/ENSPREG00000015004/ENSPREG00000002018/ENSPREG00000013775/ENSPREG00000006479/ENSPREG00000013601/ENSPREG00000009351/ENSPREG00000009731/ENSPREG00000018100/ENSPREG00000017420/ENSPREG00000012360/ENSPREG00000008939/ENSPREG00000006060/ENSPREG00000004380/ENSPREG00000013995/ENSPREG00000018387/ENSPREG00000016519/ENSPREG00000001598/ENSPREG00000018881/ENSPREG00000017783/ENSPREG00000022899/ENSPREG00000022906/ENSPREG00000011721/ENSPREG00000013686/ENSPREG00000016437/ENSPREG00000011212/ENSPREG00000012367/ENSPREG00000017575/ENSPREG00000008858/ENSPREG00000015711/ENSPREG00000018486/ENSPREG00000018056/ENSPREG00000004772/ENSPREG00000009356/ENSPREG00000006969/ENSPREG00000013087/ENSPREG00000022246/ENSPREG00000006322/ENSPREG00000002822/ENSPREG00000011546/ENSPREG00000019601/ENSPREG00000008698/ENSPREG00000013840/ENSPREG00000013651/ENSPREG00000004768/ENSPREG00000011938/ENSPREG00000003572/ENSPREG00000019394
## GO:0003677 DNA binding ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000019590/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000013122/ENSPREG00000021021/ENSPREG00000023222/ENSPREG00000015916/ENSPREG00000004581/ENSPREG00000013636/ENSPREG00000014960/ENSPREG00000013353/ENSPREG00000019423/ENSPREG00000021725/ENSPREG00000014513/ENSPREG00000011544/ENSPREG00000020875/ENSPREG00000008787/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000014745/ENSPREG00000013420/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000011707/ENSPREG00000013386/ENSPREG00000001606/ENSPREG00000018748/ENSPREG00000006489/ENSPREG00000016918/ENSPREG00000014279/ENSPREG00000020534/ENSPREG00000015854/ENSPREG00000021691/ENSPREG00000014440/ENSPREG00000018134/ENSPREG00000008300/ENSPREG00000008224/ENSPREG00000019762/ENSPREG00000013694/ENSPREG00000004375/ENSPREG00000004289/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000008658/ENSPREG00000000142/ENSPREG00000013058/ENSPREG00000012699/ENSPREG00000017112/ENSPREG00000018565/ENSPREG00000004079/ENSPREG00000002403/ENSPREG00000001340/ENSPREG00000005288/ENSPREG00000008785/ENSPREG00000010009/ENSPREG00000003558/ENSPREG00000020684/ENSPREG00000015004/ENSPREG00000020249/ENSPREG00000001364/ENSPREG00000006621/ENSPREG00000018868/ENSPREG00000017943/ENSPREG00000008636/ENSPREG00000020298/ENSPREG00000002018/ENSPREG00000020340/ENSPREG00000017440/ENSPREG00000008234/ENSPREG00000013775/ENSPREG00000010190/ENSPREG00000003001/ENSPREG00000001346/ENSPREG00000004743/ENSPREG00000006479/ENSPREG00000005343/ENSPREG00000003838/ENSPREG00000008307/ENSPREG00000013601/ENSPREG00000019385/ENSPREG00000018224/ENSPREG00000014517/ENSPREG00000006787/ENSPREG00000006190/ENSPREG00000009351/ENSPREG00000011305/ENSPREG00000017159/ENSPREG00000010210/ENSPREG00000007323/ENSPREG00000005805/ENSPREG00000009731/ENSPREG00000005657/ENSPREG00000010783/ENSPREG00000013048/ENSPREG00000018024/ENSPREG00000016694/ENSPREG00000004266/ENSPREG00000001397/ENSPREG00000014413/ENSPREG00000018820/ENSPREG00000017420/ENSPREG00000008763/ENSPREG00000008233/ENSPREG00000011115/ENSPREG00000005286/ENSPREG00000012547/ENSPREG00000007733/ENSPREG00000014285/ENSPREG00000008939/ENSPREG00000010863/ENSPREG00000019278/ENSPREG00000023206/ENSPREG00000002904/ENSPREG00000021719/ENSPREG00000002632/ENSPREG00000000644/ENSPREG00000017120/ENSPREG00000004380/ENSPREG00000012739/ENSPREG00000019570/ENSPREG00000006716/ENSPREG00000011496/ENSPREG00000004090/ENSPREG00000013995/ENSPREG00000008141/ENSPREG00000016198/ENSPREG00000018249/ENSPREG00000016109/ENSPREG00000018387/ENSPREG00000007818/ENSPREG00000019670/ENSPREG00000005517/ENSPREG00000013650/ENSPREG00000016519/ENSPREG00000023099/ENSPREG00000001598/ENSPREG00000000683/ENSPREG00000018973/ENSPREG00000011871/ENSPREG00000005851/ENSPREG00000022267/ENSPREG00000018881/ENSPREG00000017276/ENSPREG00000019908/ENSPREG00000008128/ENSPREG00000022182/ENSPREG00000022983/ENSPREG00000010865/ENSPREG00000017783/ENSPREG00000020349/ENSPREG00000012325/ENSPREG00000022899/ENSPREG00000022906/ENSPREG00000009470/ENSPREG00000018976/ENSPREG00000011721/ENSPREG00000004628/ENSPREG00000019546/ENSPREG00000015073/ENSPREG00000013686/ENSPREG00000021227/ENSPREG00000002385/ENSPREG00000013623/ENSPREG00000016437/ENSPREG00000008992/ENSPREG00000011212/ENSPREG00000020505/ENSPREG00000012254/ENSPREG00000012367/ENSPREG00000022812/ENSPREG00000017575/ENSPREG00000000939/ENSPREG00000019566/ENSPREG00000001559/ENSPREG00000008858/ENSPREG00000017296/ENSPREG00000009725/ENSPREG00000000532/ENSPREG00000015711/ENSPREG00000008109/ENSPREG00000005806/ENSPREG00000010240/ENSPREG00000018486/ENSPREG00000014876/ENSPREG00000004772/ENSPREG00000009356/ENSPREG00000008242/ENSPREG00000004775/ENSPREG00000011089/ENSPREG00000010913/ENSPREG00000014867/ENSPREG00000019480/ENSPREG00000007900/ENSPREG00000022246/ENSPREG00000014523/ENSPREG00000020306/ENSPREG00000021407/ENSPREG00000013155/ENSPREG00000017494/ENSPREG00000006276/ENSPREG00000020918/ENSPREG00000006322/ENSPREG00000013765/ENSPREG00000002822/ENSPREG00000006003/ENSPREG00000022075/ENSPREG00000021885/ENSPREG00000006772/ENSPREG00000003939/ENSPREG00000011546/ENSPREG00000012120/ENSPREG00000022283/ENSPREG00000015692/ENSPREG00000012582/ENSPREG00000012819/ENSPREG00000004425/ENSPREG00000019019/ENSPREG00000020577/ENSPREG00000017901/ENSPREG00000019601/ENSPREG00000011939/ENSPREG00000013115/ENSPREG00000015816/ENSPREG00000019608/ENSPREG00000008698/ENSPREG00000014298/ENSPREG00000013840/ENSPREG00000009616/ENSPREG00000009074/ENSPREG00000019092/ENSPREG00000001432/ENSPREG00000021255/ENSPREG00000015884/ENSPREG00000013313/ENSPREG00000019568/ENSPREG00000017553/ENSPREG00000009851/ENSPREG00000013651/ENSPREG00000006705/ENSPREG00000015810/ENSPREG00000012858/ENSPREG00000004768/ENSPREG00000004514/ENSPREG00000011938/ENSPREG00000016371/ENSPREG00000014784/ENSPREG00000003572
## GO:0015075 ion transmembrane transporter activity ENSPREG00000005776/ENSPREG00000007011/ENSPREG00000013279/ENSPREG00000003778/ENSPREG00000013471
## GO:0004340 glucokinase activity ENSPREG00000014828/ENSPREG00000012652/ENSPREG00000010287/ENSPREG00000021465/ENSPREG00000009311
## GO:0051156 glucose 6-phosphate metabolic process ENSPREG00000014828/ENSPREG00000012652/ENSPREG00000010287/ENSPREG00000021465/ENSPREG00000009311
## GO:0060322 head development ENSPREG00000008409/ENSPREG00000008456/ENSPREG00000016649/ENSPREG00000012139/ENSPREG00000013448
## GO:0004000 adenosine deaminase activity ENSPREG00000020270/ENSPREG00000016600/ENSPREG00000006572/ENSPREG00000006236/ENSPREG00000020675/ENSPREG00000003181
## GO:0030513 positive regulation of BMP signaling pathway ENSPREG00000018051/ENSPREG00000019287/ENSPREG00000020925/ENSPREG00000022947/ENSPREG00000018278/ENSPREG00000006960
## GO:0031017 exocrine pancreas development ENSPREG00000004106/ENSPREG00000011570/ENSPREG00000008300/ENSPREG00000001012/ENSPREG00000008858/ENSPREG00000000741/ENSPREG00000019499/ENSPREG00000005893/ENSPREG00000005265/ENSPREG00000002146/ENSPREG00000017553/ENSPREG00000002408
## GO:0051056 regulation of small GTPase mediated signal transduction ENSPREG00000006302/ENSPREG00000021844/ENSPREG00000010160/ENSPREG00000019661/ENSPREG00000005509/ENSPREG00000006207/ENSPREG00000008451/ENSPREG00000007850
## GO:0007062 sister chromatid cohesion ENSPREG00000012360/ENSPREG00000002380/ENSPREG00000016517/ENSPREG00000017552
## GO:0030111 regulation of Wnt signaling pathway ENSPREG00000006261/ENSPREG00000021155/ENSPREG00000019287/ENSPREG00000003447
## GO:0060729 intestinal epithelial structure maintenance ENSPREG00000008971/ENSPREG00000011304/ENSPREG00000008141/ENSPREG00000000741
## GO:0001678 cellular glucose homeostasis ENSPREG00000014828/ENSPREG00000012652/ENSPREG00000010287/ENSPREG00000021465/ENSPREG00000009311
## GO:0004396 hexokinase activity ENSPREG00000014828/ENSPREG00000012652/ENSPREG00000010287/ENSPREG00000021465/ENSPREG00000009311
## Count
## GO:0043565 sequence-specific DNA binding 60
## GO:0003677 DNA binding 250
## GO:0015075 ion transmembrane transporter activity 5
## GO:0004340 glucokinase activity 5
## GO:0051156 glucose 6-phosphate metabolic process 5
## GO:0060322 head development 5
## GO:0004000 adenosine deaminase activity 6
## GO:0030513 positive regulation of BMP signaling pathway 6
## GO:0031017 exocrine pancreas development 12
## GO:0051056 regulation of small GTPase mediated signal transduction 8
## GO:0007062 sister chromatid cohesion 4
## GO:0030111 regulation of Wnt signaling pathway 4
## GO:0060729 intestinal epithelial structure maintenance 4
## GO:0001678 cellular glucose homeostasis 5
## GO:0004396 hexokinase activity 5CvLunion <- union(CvL_up,CvL_dn)
c_union <- enricher(gene = CvLunion, universe = CvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_union,15)## ID
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0043565 sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0048471 perinuclear region of cytoplasm GO:0048471 perinuclear region of cytoplasm
## GO:0015075 ion transmembrane transporter activity GO:0015075 ion transmembrane transporter activity
## GO:0030513 positive regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway
## GO:1902476 chloride transmembrane transport GO:1902476 chloride transmembrane transport
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0009887 animal organ morphogenesis GO:0009887 animal organ morphogenesis
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0006885 regulation of pH GO:0006885 regulation of pH
## GO:0009190 cyclic nucleotide biosynthetic process GO:0009190 cyclic nucleotide biosynthetic process
## Description
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0043565 sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0048471 perinuclear region of cytoplasm GO:0048471 perinuclear region of cytoplasm
## GO:0015075 ion transmembrane transporter activity GO:0015075 ion transmembrane transporter activity
## GO:0030513 positive regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway
## GO:1902476 chloride transmembrane transport GO:1902476 chloride transmembrane transport
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0009887 animal organ morphogenesis GO:0009887 animal organ morphogenesis
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0006885 regulation of pH GO:0006885 regulation of pH
## GO:0009190 cyclic nucleotide biosynthetic process GO:0009190 cyclic nucleotide biosynthetic process
## GeneRatio
## GO:0003677 DNA binding 402/5544
## GO:0007275 multicellular organism development 184/5544
## GO:0005634 nucleus 716/5544
## GO:0043565 sequence-specific DNA binding 91/5544
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 103/5544
## GO:0048471 perinuclear region of cytoplasm 19/5544
## GO:0015075 ion transmembrane transporter activity 6/5544
## GO:0030513 positive regulation of BMP signaling pathway 8/5544
## GO:1902476 chloride transmembrane transport 8/5544
## GO:0003700 DNA-binding transcription factor activity 167/5544
## GO:0005515 protein binding 1099/5544
## GO:0009887 animal organ morphogenesis 9/5544
## GO:0006355 regulation of transcription, DNA-templated 300/5544
## GO:0006885 regulation of pH 8/5544
## GO:0009190 cyclic nucleotide biosynthetic process 16/5544
## BgRatio
## GO:0003677 DNA binding 1131/18067
## GO:0007275 multicellular organism development 480/18067
## GO:0005634 nucleus 2106/18067
## GO:0043565 sequence-specific DNA binding 221/18067
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18067
## GO:0048471 perinuclear region of cytoplasm 35/18067
## GO:0015075 ion transmembrane transporter activity 7/18067
## GO:0030513 positive regulation of BMP signaling pathway 11/18067
## GO:1902476 chloride transmembrane transport 11/18067
## GO:0003700 DNA-binding transcription factor activity 463/18067
## GO:0005515 protein binding 3391/18067
## GO:0009887 animal organ morphogenesis 14/18067
## GO:0006355 regulation of transcription, DNA-templated 875/18067
## GO:0006885 regulation of pH 12/18067
## GO:0009190 cyclic nucleotide biosynthetic process 31/18067
## pvalue
## GO:0003677 DNA binding 0.0001689850
## GO:0007275 multicellular organism development 0.0001798022
## GO:0005634 nucleus 0.0002743424
## GO:0043565 sequence-specific DNA binding 0.0005699700
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0012765898
## GO:0048471 perinuclear region of cytoplasm 0.0030766027
## GO:0015075 ion transmembrane transporter activity 0.0043000915
## GO:0030513 positive regulation of BMP signaling pathway 0.0050035570
## GO:1902476 chloride transmembrane transport 0.0050035570
## GO:0003700 DNA-binding transcription factor activity 0.0068640273
## GO:0005515 protein binding 0.0085075763
## GO:0009887 animal organ morphogenesis 0.0097201957
## GO:0006355 regulation of transcription, DNA-templated 0.0104028186
## GO:0006885 regulation of pH 0.0109805817
## GO:0009190 cyclic nucleotide biosynthetic process 0.0119545392
## p.adjust
## GO:0003677 DNA binding 0.1551693
## GO:0007275 multicellular organism development 0.1551693
## GO:0005634 nucleus 0.1578383
## GO:0043565 sequence-specific DNA binding 0.2459421
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4406788
## GO:0048471 perinuclear region of cytoplasm 0.8850361
## GO:0015075 ion transmembrane transporter activity 0.9142820
## GO:0030513 positive regulation of BMP signaling pathway 0.9142820
## GO:1902476 chloride transmembrane transport 0.9142820
## GO:0003700 DNA-binding transcription factor activity 0.9142820
## GO:0005515 protein binding 0.9142820
## GO:0009887 animal organ morphogenesis 0.9142820
## GO:0006355 regulation of transcription, DNA-templated 0.9142820
## GO:0006885 regulation of pH 0.9142820
## GO:0009190 cyclic nucleotide biosynthetic process 0.9142820
## qvalue
## GO:0003677 DNA binding 0.1551693
## GO:0007275 multicellular organism development 0.1551693
## GO:0005634 nucleus 0.1578383
## GO:0043565 sequence-specific DNA binding 0.2459421
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4406788
## GO:0048471 perinuclear region of cytoplasm 0.8850361
## GO:0015075 ion transmembrane transporter activity 0.9142820
## GO:0030513 positive regulation of BMP signaling pathway 0.9142820
## GO:1902476 chloride transmembrane transport 0.9142820
## GO:0003700 DNA-binding transcription factor activity 0.9142820
## GO:0005515 protein binding 0.9142820
## GO:0009887 animal organ morphogenesis 0.9142820
## GO:0006355 regulation of transcription, DNA-templated 0.9142820
## GO:0006885 regulation of pH 0.9142820
## GO:0009190 cyclic nucleotide biosynthetic process 0.9142820
## geneID
## GO:0003677 DNA binding ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000014413/ENSPREG00000004595/ENSPREG00000001380/ENSPREG00000019101/ENSPREG00000004107/ENSPREG00000001606/ENSPREG00000009351/ENSPREG00000010174/ENSPREG00000010341/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000012367/ENSPREG00000002117/ENSPREG00000006450/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000015529/ENSPREG00000015289/ENSPREG00000012188/ENSPREG00000016605/ENSPREG00000005993/ENSPREG00000014446/ENSPREG00000013213/ENSPREG00000004581/ENSPREG00000018786/ENSPREG00000011157/ENSPREG00000013196/ENSPREG00000015341/ENSPREG00000012003/ENSPREG00000010940/ENSPREG00000017440/ENSPREG00000003428/ENSPREG00000016437/ENSPREG00000017164/ENSPREG00000021691/ENSPREG00000004218/ENSPREG00000007733/ENSPREG00000013067/ENSPREG00000015542/ENSPREG00000009356/ENSPREG00000012184/ENSPREG00000003897/ENSPREG00000008234/ENSPREG00000010797/ENSPREG00000012547/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000002923/ENSPREG00000018024/ENSPREG00000007643/ENSPREG00000014049/ENSPREG00000022088/ENSPREG00000022317/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000005038/ENSPREG00000022277/ENSPREG00000014985/ENSPREG00000018023/ENSPREG00000018193/ENSPREG00000014803/ENSPREG00000021553/ENSPREG00000022267/ENSPREG00000021274/ENSPREG00000014523/ENSPREG00000015738/ENSPREG00000003423/ENSPREG00000019519/ENSPREG00000018746/ENSPREG00000009131/ENSPREG00000002487/ENSPREG00000012950/ENSPREG00000016198/ENSPREG00000012663/ENSPREG00000012105/ENSPREG00000008418/ENSPREG00000014369/ENSPREG00000012965/ENSPREG00000017553/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000008402/ENSPREG00000011942/ENSPREG00000021669/ENSPREG00000011496/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000001369/ENSPREG00000020625/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000001598/ENSPREG00000021365/ENSPREG00000016234/ENSPREG00000006061/ENSPREG00000003558/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000009925/ENSPREG00000015465/ENSPREG00000008666/ENSPREG00000015395/ENSPREG00000014215/ENSPREG00000001114/ENSPREG00000021474/ENSPREG00000000568/ENSPREG00000012765/ENSPREG00000009198/ENSPREG00000015905/ENSPREG00000008337/ENSPREG00000012389/ENSPREG00000015331/ENSPREG00000001395/ENSPREG00000014770/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000012499/ENSPREG00000017365/ENSPREG00000022194/ENSPREG00000010656/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000021586/ENSPREG00000000644/ENSPREG00000008761/ENSPREG00000006077/ENSPREG00000000227/ENSPREG00000021410/ENSPREG00000006606/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000001756/ENSPREG00000001199/ENSPREG00000017524/ENSPREG00000014826/ENSPREG00000017740/ENSPREG00000018565/ENSPREG00000006388/ENSPREG00000016109/ENSPREG00000019599/ENSPREG00000023206/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000022457/ENSPREG00000006460/ENSPREG00000022930/ENSPREG00000017666/ENSPREG00000010486/ENSPREG00000010954/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000006368/ENSPREG00000005136/ENSPREG00000019859/ENSPREG00000010250/ENSPREG00000013651/ENSPREG00000013766/ENSPREG00000015597/ENSPREG00000014774/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000002365/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000020877/ENSPREG00000004514/ENSPREG00000015884/ENSPREG00000004768/ENSPREG00000004628/ENSPREG00000023255/ENSPREG00000010865/ENSPREG00000011707/ENSPREG00000022075/ENSPREG00000018761/ENSPREG00000015470/ENSPREG00000020876/ENSPREG00000020281/ENSPREG00000008500/ENSPREG00000022924/ENSPREG00000000237/ENSPREG00000016149/ENSPREG00000008636/ENSPREG00000022772/ENSPREG00000002123/ENSPREG00000017050/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000019590/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000013122/ENSPREG00000021021/ENSPREG00000023222/ENSPREG00000015916/ENSPREG00000013636/ENSPREG00000014960/ENSPREG00000013353/ENSPREG00000019423/ENSPREG00000014513/ENSPREG00000011544/ENSPREG00000020875/ENSPREG00000008787/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000014745/ENSPREG00000013420/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000013386/ENSPREG00000018748/ENSPREG00000006489/ENSPREG00000014279/ENSPREG00000020534/ENSPREG00000015854/ENSPREG00000018134/ENSPREG00000008300/ENSPREG00000008224/ENSPREG00000019762/ENSPREG00000013694/ENSPREG00000004375/ENSPREG00000004289/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000008658/ENSPREG00000000142/ENSPREG00000013058/ENSPREG00000012699/ENSPREG00000017112/ENSPREG00000004079/ENSPREG00000002403/ENSPREG00000001340/ENSPREG00000008785/ENSPREG00000010009/ENSPREG00000020684/ENSPREG00000015004/ENSPREG00000020249/ENSPREG00000001364/ENSPREG00000006621/ENSPREG00000018868/ENSPREG00000017943/ENSPREG00000020298/ENSPREG00000002018/ENSPREG00000013775/ENSPREG00000010190/ENSPREG00000003001/ENSPREG00000001346/ENSPREG00000004743/ENSPREG00000006479/ENSPREG00000005343/ENSPREG00000003838/ENSPREG00000008307/ENSPREG00000019385/ENSPREG00000018224/ENSPREG00000014517/ENSPREG00000006787/ENSPREG00000006190/ENSPREG00000011305/ENSPREG00000017159/ENSPREG00000010210/ENSPREG00000007323/ENSPREG00000005805/ENSPREG00000009731/ENSPREG00000005657/ENSPREG00000010783/ENSPREG00000013048/ENSPREG00000016694/ENSPREG00000004266/ENSPREG00000001397/ENSPREG00000018820/ENSPREG00000017420/ENSPREG00000008763/ENSPREG00000008233/ENSPREG00000005286/ENSPREG00000014285/ENSPREG00000008939/ENSPREG00000010863/ENSPREG00000019278/ENSPREG00000002904/ENSPREG00000021719/ENSPREG00000002632/ENSPREG00000017120/ENSPREG00000004380/ENSPREG00000012739/ENSPREG00000019570/ENSPREG00000006716/ENSPREG00000004090/ENSPREG00000013995/ENSPREG00000008141/ENSPREG00000018249/ENSPREG00000018387/ENSPREG00000007818/ENSPREG00000019670/ENSPREG00000005517/ENSPREG00000013650/ENSPREG00000016519/ENSPREG00000023099/ENSPREG00000000683/ENSPREG00000018973/ENSPREG00000011871/ENSPREG00000005851/ENSPREG00000018881/ENSPREG00000017276/ENSPREG00000019908/ENSPREG00000008128/ENSPREG00000022182/ENSPREG00000022983/ENSPREG00000017783/ENSPREG00000020349/ENSPREG00000022899/ENSPREG00000009470/ENSPREG00000018976/ENSPREG00000011721/ENSPREG00000019546/ENSPREG00000015073/ENSPREG00000013686/ENSPREG00000021227/ENSPREG00000002385/ENSPREG00000013623/ENSPREG00000008992/ENSPREG00000011212/ENSPREG00000020505/ENSPREG00000012254/ENSPREG00000022812/ENSPREG00000017575/ENSPREG00000000939/ENSPREG00000019566/ENSPREG00000001559/ENSPREG00000008858/ENSPREG00000017296/ENSPREG00000009725/ENSPREG00000015711/ENSPREG00000008109/ENSPREG00000005806/ENSPREG00000010240/ENSPREG00000018486/ENSPREG00000014876/ENSPREG00000004772/ENSPREG00000008242/ENSPREG00000004775/ENSPREG00000011089/ENSPREG00000010913/ENSPREG00000014867/ENSPREG00000019480/ENSPREG00000007900/ENSPREG00000022246/ENSPREG00000020306/ENSPREG00000021407/ENSPREG00000013155/ENSPREG00000017494/ENSPREG00000006276/ENSPREG00000020918/ENSPREG00000006322/ENSPREG00000013765/ENSPREG00000002822/ENSPREG00000006003/ENSPREG00000021885/ENSPREG00000006772/ENSPREG00000003939/ENSPREG00000011546/ENSPREG00000012120/ENSPREG00000022283/ENSPREG00000015692/ENSPREG00000012819/ENSPREG00000004425/ENSPREG00000019019/ENSPREG00000020577/ENSPREG00000017901/ENSPREG00000019601/ENSPREG00000011939/ENSPREG00000013115/ENSPREG00000015816/ENSPREG00000019608/ENSPREG00000008698/ENSPREG00000014298/ENSPREG00000013840/ENSPREG00000009616/ENSPREG00000009074/ENSPREG00000019092/ENSPREG00000001432/ENSPREG00000021255/ENSPREG00000013313/ENSPREG00000019568/ENSPREG00000009851/ENSPREG00000006705/ENSPREG00000015810/ENSPREG00000012858/ENSPREG00000011938/ENSPREG00000016371/ENSPREG00000014784/ENSPREG00000003572
## GO:0007275 multicellular organism development ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000007669/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000002117/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000005482/ENSPREG00000018360/ENSPREG00000016605/ENSPREG00000013196/ENSPREG00000017440/ENSPREG00000011227/ENSPREG00000009356/ENSPREG00000010797/ENSPREG00000019060/ENSPREG00000014049/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000022277/ENSPREG00000019287/ENSPREG00000018739/ENSPREG00000018023/ENSPREG00000015614/ENSPREG00000021144/ENSPREG00000018652/ENSPREG00000021274/ENSPREG00000003423/ENSPREG00000009131/ENSPREG00000012105/ENSPREG00000014369/ENSPREG00000020385/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000021420/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000013601/ENSPREG00000001369/ENSPREG00000004544/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000016234/ENSPREG00000021106/ENSPREG00000006008/ENSPREG00000000612/ENSPREG00000015465/ENSPREG00000021474/ENSPREG00000008357/ENSPREG00000000568/ENSPREG00000017388/ENSPREG00000009198/ENSPREG00000015936/ENSPREG00000015331/ENSPREG00000010656/ENSPREG00000008761/ENSPREG00000006606/ENSPREG00000010035/ENSPREG00000006767/ENSPREG00000016622/ENSPREG00000006388/ENSPREG00000023206/ENSPREG00000006544/ENSPREG00000020667/ENSPREG00000017666/ENSPREG00000008801/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000005136/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000009355/ENSPREG00000014891/ENSPREG00000007139/ENSPREG00000018675/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000015884/ENSPREG00000003313/ENSPREG00000004067/ENSPREG00000015470/ENSPREG00000002598/ENSPREG00000008500/ENSPREG00000019995/ENSPREG00000001918/ENSPREG00000002123/ENSPREG00000014903/ENSPREG00000021010/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000000133/ENSPREG00000023233/ENSPREG00000014079/ENSPREG00000013636/ENSPREG00000010790/ENSPREG00000008016/ENSPREG00000013353/ENSPREG00000004106/ENSPREG00000004667/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000002679/ENSPREG00000008534/ENSPREG00000014279/ENSPREG00000009944/ENSPREG00000011176/ENSPREG00000008300/ENSPREG00000019762/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000009870/ENSPREG00000013058/ENSPREG00000001340/ENSPREG00000001364/ENSPREG00000018868/ENSPREG00000020298/ENSPREG00000003001/ENSPREG00000001346/ENSPREG00000011756/ENSPREG00000006479/ENSPREG00000005343/ENSPREG00000016378/ENSPREG00000006787/ENSPREG00000006190/ENSPREG00000009731/ENSPREG00000005657/ENSPREG00000010783/ENSPREG00000013048/ENSPREG00000016694/ENSPREG00000001397/ENSPREG00000021719/ENSPREG00000001227/ENSPREG00000019570/ENSPREG00000001810/ENSPREG00000006716/ENSPREG00000007694/ENSPREG00000011038/ENSPREG00000008325/ENSPREG00000019670/ENSPREG00000016519/ENSPREG00000000683/ENSPREG00000005851/ENSPREG00000022983/ENSPREG00000001835/ENSPREG00000020349/ENSPREG00000006129/ENSPREG00000011721/ENSPREG00000021227/ENSPREG00000020505/ENSPREG00000014719/ENSPREG00000008858/ENSPREG00000001265/ENSPREG00000011636/ENSPREG00000011089/ENSPREG00000007900/ENSPREG00000020306/ENSPREG00000021407/ENSPREG00000010793/ENSPREG00000006276/ENSPREG00000009481/ENSPREG00000002146/ENSPREG00000021885/ENSPREG00000012787/ENSPREG00000006772/ENSPREG00000015692/ENSPREG00000012819/ENSPREG00000017901/ENSPREG00000001804/ENSPREG00000000964/ENSPREG00000006705/ENSPREG00000015810/ENSPREG00000014784
## GO:0005634 nucleus ENSPREG00000011953/ENSPREG00000021725/ENSPREG00000011868/ENSPREG00000004660/ENSPREG00000014413/ENSPREG00000015451/ENSPREG00000002287/ENSPREG00000011568/ENSPREG00000022114/ENSPREG00000001380/ENSPREG00000012357/ENSPREG00000019101/ENSPREG00000004107/ENSPREG00000001606/ENSPREG00000009351/ENSPREG00000010174/ENSPREG00000022340/ENSPREG00000003434/ENSPREG00000019660/ENSPREG00000012325/ENSPREG00000000312/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000001505/ENSPREG00000007342/ENSPREG00000012367/ENSPREG00000019472/ENSPREG00000018852/ENSPREG00000011799/ENSPREG00000007722/ENSPREG00000002117/ENSPREG00000011856/ENSPREG00000005028/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000008389/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000005482/ENSPREG00000017808/ENSPREG00000010644/ENSPREG00000016347/ENSPREG00000017205/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000016534/ENSPREG00000013639/ENSPREG00000014531/ENSPREG00000016605/ENSPREG00000005993/ENSPREG00000014446/ENSPREG00000013940/ENSPREG00000009394/ENSPREG00000004581/ENSPREG00000018786/ENSPREG00000013384/ENSPREG00000013196/ENSPREG00000012003/ENSPREG00000009984/ENSPREG00000019274/ENSPREG00000017440/ENSPREG00000021982/ENSPREG00000003428/ENSPREG00000015828/ENSPREG00000000447/ENSPREG00000007638/ENSPREG00000003295/ENSPREG00000016437/ENSPREG00000017164/ENSPREG00000001484/ENSPREG00000018613/ENSPREG00000021691/ENSPREG00000003918/ENSPREG00000004218/ENSPREG00000020193/ENSPREG00000008997/ENSPREG00000013067/ENSPREG00000006372/ENSPREG00000009356/ENSPREG00000000386/ENSPREG00000012184/ENSPREG00000003897/ENSPREG00000010797/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000003440/ENSPREG00000002923/ENSPREG00000013896/ENSPREG00000009540/ENSPREG00000022466/ENSPREG00000018024/ENSPREG00000022696/ENSPREG00000022365/ENSPREG00000014049/ENSPREG00000022088/ENSPREG00000016797/ENSPREG00000008456/ENSPREG00000020203/ENSPREG00000012868/ENSPREG00000005038/ENSPREG00000005223/ENSPREG00000007173/ENSPREG00000022277/ENSPREG00000020685/ENSPREG00000016742/ENSPREG00000005527/ENSPREG00000010381/ENSPREG00000014985/ENSPREG00000018023/ENSPREG00000013858/ENSPREG00000016063/ENSPREG00000018405/ENSPREG00000006464/ENSPREG00000018193/ENSPREG00000021362/ENSPREG00000018972/ENSPREG00000014803/ENSPREG00000000378/ENSPREG00000021553/ENSPREG00000003192/ENSPREG00000022267/ENSPREG00000021274/ENSPREG00000017405/ENSPREG00000007784/ENSPREG00000014523/ENSPREG00000005151/ENSPREG00000015738/ENSPREG00000018925/ENSPREG00000003423/ENSPREG00000010877/ENSPREG00000012529/ENSPREG00000018272/ENSPREG00000018746/ENSPREG00000009131/ENSPREG00000002487/ENSPREG00000007244/ENSPREG00000019470/ENSPREG00000012950/ENSPREG00000016198/ENSPREG00000011482/ENSPREG00000012663/ENSPREG00000012105/ENSPREG00000018630/ENSPREG00000008156/ENSPREG00000008418/ENSPREG00000008711/ENSPREG00000005278/ENSPREG00000005000/ENSPREG00000012965/ENSPREG00000017836/ENSPREG00000004058/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000001047/ENSPREG00000021700/ENSPREG00000011942/ENSPREG00000000639/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000015111/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000015315/ENSPREG00000018564/ENSPREG00000000136/ENSPREG00000001369/ENSPREG00000020625/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000003891/ENSPREG00000001598/ENSPREG00000016234/ENSPREG00000006038/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000010135/ENSPREG00000009925/ENSPREG00000015465/ENSPREG00000008666/ENSPREG00000008743/ENSPREG00000011827/ENSPREG00000020416/ENSPREG00000000793/ENSPREG00000015258/ENSPREG00000019319/ENSPREG00000014215/ENSPREG00000008960/ENSPREG00000010768/ENSPREG00000012719/ENSPREG00000020303/ENSPREG00000004213/ENSPREG00000001114/ENSPREG00000000568/ENSPREG00000007804/ENSPREG00000019031/ENSPREG00000013255/ENSPREG00000015981/ENSPREG00000009198/ENSPREG00000018196/ENSPREG00000015905/ENSPREG00000021952/ENSPREG00000008337/ENSPREG00000008276/ENSPREG00000015331/ENSPREG00000006032/ENSPREG00000006079/ENSPREG00000001395/ENSPREG00000014770/ENSPREG00000005288/ENSPREG00000003052/ENSPREG00000020093/ENSPREG00000020466/ENSPREG00000017365/ENSPREG00000002617/ENSPREG00000022194/ENSPREG00000010656/ENSPREG00000002331/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000000644/ENSPREG00000020796/ENSPREG00000021642/ENSPREG00000008761/ENSPREG00000000227/ENSPREG00000021410/ENSPREG00000017378/ENSPREG00000022485/ENSPREG00000002499/ENSPREG00000019694/ENSPREG00000022223/ENSPREG00000006606/ENSPREG00000005818/ENSPREG00000017291/ENSPREG00000009483/ENSPREG00000000662/ENSPREG00000021495/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000004782/ENSPREG00000017370/ENSPREG00000001155/ENSPREG00000021835/ENSPREG00000003285/ENSPREG00000005356/ENSPREG00000003764/ENSPREG00000018923/ENSPREG00000014826/ENSPREG00000020464/ENSPREG00000018565/ENSPREG00000006388/ENSPREG00000011196/ENSPREG00000015751/ENSPREG00000017854/ENSPREG00000015075/ENSPREG00000016109/ENSPREG00000019599/ENSPREG00000015503/ENSPREG00000004835/ENSPREG00000000100/ENSPREG00000001897/ENSPREG00000023206/ENSPREG00000003049/ENSPREG00000000694/ENSPREG00000006242/ENSPREG00000021707/ENSPREG00000007951/ENSPREG00000005599/ENSPREG00000020878/ENSPREG00000021865/ENSPREG00000006212/ENSPREG00000010684/ENSPREG00000022906/ENSPREG00000008235/ENSPREG00000022457/ENSPREG00000011388/ENSPREG00000006460/ENSPREG00000002677/ENSPREG00000001500/ENSPREG00000009177/ENSPREG00000004357/ENSPREG00000001222/ENSPREG00000020471/ENSPREG00000014973/ENSPREG00000013848/ENSPREG00000006544/ENSPREG00000017666/ENSPREG00000010486/ENSPREG00000010954/ENSPREG00000012420/ENSPREG00000006249/ENSPREG00000005374/ENSPREG00000006368/ENSPREG00000005136/ENSPREG00000019859/ENSPREG00000010250/ENSPREG00000018463/ENSPREG00000019898/ENSPREG00000018266/ENSPREG00000019315/ENSPREG00000013651/ENSPREG00000007743/ENSPREG00000007210/ENSPREG00000013766/ENSPREG00000019517/ENSPREG00000018366/ENSPREG00000016210/ENSPREG00000015597/ENSPREG00000005401/ENSPREG00000021784/ENSPREG00000005552/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000020100/ENSPREG00000018675/ENSPREG00000002365/ENSPREG00000013087/ENSPREG00000004757/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000020877/ENSPREG00000004514/ENSPREG00000019394/ENSPREG00000009744/ENSPREG00000021857/ENSPREG00000015884/ENSPREG00000001387/ENSPREG00000004768/ENSPREG00000018793/ENSPREG00000011959/ENSPREG00000004628/ENSPREG00000010182/ENSPREG00000003677/ENSPREG00000015137/ENSPREG00000019858/ENSPREG00000021901/ENSPREG00000008937/ENSPREG00000011707/ENSPREG00000022075/ENSPREG00000016194/ENSPREG00000022711/ENSPREG00000000473/ENSPREG00000010143/ENSPREG00000018761/ENSPREG00000015470/ENSPREG00000020853/ENSPREG00000008500/ENSPREG00000002665/ENSPREG00000008032/ENSPREG00000022924/ENSPREG00000003148/ENSPREG00000017403/ENSPREG00000016149/ENSPREG00000008636/ENSPREG00000022772/ENSPREG00000007026/ENSPREG00000004345/ENSPREG00000001918/ENSPREG00000002123/ENSPREG00000017050/ENSPREG00000008906/ENSPREG00000013887/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000015203/ENSPREG00000019590/ENSPREG00000003481/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000013122/ENSPREG00000021021/ENSPREG00000000133/ENSPREG00000023222/ENSPREG00000015916/ENSPREG00000016792/ENSPREG00000004901/ENSPREG00000001808/ENSPREG00000009968/ENSPREG00000017363/ENSPREG00000013607/ENSPREG00000005863/ENSPREG00000013636/ENSPREG00000005313/ENSPREG00000018198/ENSPREG00000017309/ENSPREG00000013353/ENSPREG00000014513/ENSPREG00000020443/ENSPREG00000011544/ENSPREG00000009537/ENSPREG00000010244/ENSPREG00000020875/ENSPREG00000004667/ENSPREG00000008787/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000018087/ENSPREG00000014745/ENSPREG00000007543/ENSPREG00000004066/ENSPREG00000008651/ENSPREG00000013420/ENSPREG00000011213/ENSPREG00000022703/ENSPREG00000001464/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000009874/ENSPREG00000013386/ENSPREG00000018748/ENSPREG00000006489/ENSPREG00000018601/ENSPREG00000015213/ENSPREG00000014279/ENSPREG00000020534/ENSPREG00000004390/ENSPREG00000003072/ENSPREG00000015854/ENSPREG00000020355/ENSPREG00000014100/ENSPREG00000009334/ENSPREG00000008300/ENSPREG00000008224/ENSPREG00000019762/ENSPREG00000011402/ENSPREG00000013694/ENSPREG00000002489/ENSPREG00000004375/ENSPREG00000004289/ENSPREG00000007149/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000008658/ENSPREG00000000142/ENSPREG00000019647/ENSPREG00000013455/ENSPREG00000014911/ENSPREG00000007551/ENSPREG00000013058/ENSPREG00000012699/ENSPREG00000001746/ENSPREG00000011922/ENSPREG00000010901/ENSPREG00000018743/ENSPREG00000021907/ENSPREG00000021782/ENSPREG00000009357/ENSPREG00000018533/ENSPREG00000002982/ENSPREG00000004079/ENSPREG00000001340/ENSPREG00000017559/ENSPREG00000022635/ENSPREG00000008785/ENSPREG00000010215/ENSPREG00000020684/ENSPREG00000021773/ENSPREG00000015004/ENSPREG00000001364/ENSPREG00000018868/ENSPREG00000013528/ENSPREG00000017943/ENSPREG00000002472/ENSPREG00000020298/ENSPREG00000003601/ENSPREG00000018054/ENSPREG00000004604/ENSPREG00000002018/ENSPREG00000005287/ENSPREG00000006492/ENSPREG00000013775/ENSPREG00000010190/ENSPREG00000003001/ENSPREG00000001346/ENSPREG00000004743/ENSPREG00000007793/ENSPREG00000020582/ENSPREG00000006140/ENSPREG00000006149/ENSPREG00000006479/ENSPREG00000005343/ENSPREG00000008307/ENSPREG00000019385/ENSPREG00000018224/ENSPREG00000019870/ENSPREG00000006787/ENSPREG00000013188/ENSPREG00000006190/ENSPREG00000008483/ENSPREG00000011305/ENSPREG00000005463/ENSPREG00000022414/ENSPREG00000003013/ENSPREG00000015562/ENSPREG00000007323/ENSPREG00000016107/ENSPREG00000020764/ENSPREG00000003267/ENSPREG00000009731/ENSPREG00000022102/ENSPREG00000022051/ENSPREG00000022073/ENSPREG00000002355/ENSPREG00000005657/ENSPREG00000010783/ENSPREG00000008188/ENSPREG00000013048/ENSPREG00000018100/ENSPREG00000010651/ENSPREG00000016694/ENSPREG00000001397/ENSPREG00000018820/ENSPREG00000017420/ENSPREG00000020816/ENSPREG00000008763/ENSPREG00000009492/ENSPREG00000011517/ENSPREG00000008233/ENSPREG00000021005/ENSPREG00000020811/ENSPREG00000012360/ENSPREG00000008939/ENSPREG00000017295/ENSPREG00000011185/ENSPREG00000019550/ENSPREG00000010863/ENSPREG00000005076/ENSPREG00000012424/ENSPREG00000020390/ENSPREG00000000452/ENSPREG00000008335/ENSPREG00000023202/ENSPREG00000005399/ENSPREG00000002904/ENSPREG00000003735/ENSPREG00000006060/ENSPREG00000021719/ENSPREG00000008971/ENSPREG00000012535/ENSPREG00000019611/ENSPREG00000004380/ENSPREG00000012739/ENSPREG00000003447/ENSPREG00000016244/ENSPREG00000002557/ENSPREG00000000311/ENSPREG00000022174/ENSPREG00000006980/ENSPREG00000019570/ENSPREG00000009008/ENSPREG00000001810/ENSPREG00000006716/ENSPREG00000013447/ENSPREG00000013995/ENSPREG00000002380/ENSPREG00000008141/ENSPREG00000019148/ENSPREG00000014602/ENSPREG00000011038/ENSPREG00000018387/ENSPREG00000019670/ENSPREG00000011689/ENSPREG00000013650/ENSPREG00000016519/ENSPREG00000017727/ENSPREG00000000683/ENSPREG00000011871/ENSPREG00000005851/ENSPREG00000006358/ENSPREG00000004087/ENSPREG00000015280/ENSPREG00000022742/ENSPREG00000018881/ENSPREG00000016517/ENSPREG00000017276/ENSPREG00000008128/ENSPREG00000022182/ENSPREG00000022983/ENSPREG00000017783/ENSPREG00000020349/ENSPREG00000018730/ENSPREG00000006129/ENSPREG00000010720/ENSPREG00000014024/ENSPREG00000013329/ENSPREG00000015679/ENSPREG00000022899/ENSPREG00000009470/ENSPREG00000018976/ENSPREG00000011721/ENSPREG00000009565/ENSPREG00000022086/ENSPREG00000010311/ENSPREG00000004398/ENSPREG00000015073/ENSPREG00000013686/ENSPREG00000014444/ENSPREG00000009305/ENSPREG00000021227/ENSPREG00000002385/ENSPREG00000008992/ENSPREG00000017151/ENSPREG00000011212/ENSPREG00000020505/ENSPREG00000021437/ENSPREG00000007742/ENSPREG00000018278/ENSPREG00000012631/ENSPREG00000017575/ENSPREG00000017552/ENSPREG00000019566/ENSPREG00000008858/ENSPREG00000017296/ENSPREG00000012452/ENSPREG00000020885/ENSPREG00000009725/ENSPREG00000012318/ENSPREG00000011769/ENSPREG00000020961/ENSPREG00000015711/ENSPREG00000010347/ENSPREG00000008109/ENSPREG00000005806/ENSPREG00000017983/ENSPREG00000005945/ENSPREG00000000741/ENSPREG00000018486/ENSPREG00000008008/ENSPREG00000014906/ENSPREG00000005042/ENSPREG00000018056/ENSPREG00000018348/ENSPREG00000004772/ENSPREG00000008242/ENSPREG00000011089/ENSPREG00000003105/ENSPREG00000005893/ENSPREG00000019480/ENSPREG00000007900/ENSPREG00000023141/ENSPREG00000007275/ENSPREG00000004294/ENSPREG00000005213/ENSPREG00000022246/ENSPREG00000008458/ENSPREG00000003566/ENSPREG00000020306/ENSPREG00000023022/ENSPREG00000021407/ENSPREG00000010793/ENSPREG00000020151/ENSPREG00000013155/ENSPREG00000000238/ENSPREG00000006276/ENSPREG00000020918/ENSPREG00000006322/ENSPREG00000002822/ENSPREG00000018417/ENSPREG00000015548/ENSPREG00000006003/ENSPREG00000014924/ENSPREG00000021885/ENSPREG00000006772/ENSPREG00000006214/ENSPREG00000003939/ENSPREG00000011546/ENSPREG00000004545/ENSPREG00000015692/ENSPREG00000013105/ENSPREG00000004425/ENSPREG00000014823/ENSPREG00000019019/ENSPREG00000017901/ENSPREG00000019601/ENSPREG00000011939/ENSPREG00000013115/ENSPREG00000019669/ENSPREG00000019608/ENSPREG00000015599/ENSPREG00000008698/ENSPREG00000014298/ENSPREG00000013840/ENSPREG00000007850/ENSPREG00000009616/ENSPREG00000015366/ENSPREG00000011271/ENSPREG00000019092/ENSPREG00000005887/ENSPREG00000001432/ENSPREG00000011614/ENSPREG00000021145/ENSPREG00000013313/ENSPREG00000007602/ENSPREG00000019568/ENSPREG00000011076/ENSPREG00000002695/ENSPREG00000015440/ENSPREG00000001461/ENSPREG00000006705/ENSPREG00000015810/ENSPREG00000012858/ENSPREG00000002408/ENSPREG00000013881/ENSPREG00000013036/ENSPREG00000001534/ENSPREG00000011938/ENSPREG00000016371/ENSPREG00000014784/ENSPREG00000017386/ENSPREG00000003819/ENSPREG00000003572/ENSPREG00000021088/ENSPREG00000002991/ENSPREG00000016574
## GO:0043565 sequence-specific DNA binding ENSPREG00000009351/ENSPREG00000012367/ENSPREG00000005028/ENSPREG00000008389/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000012003/ENSPREG00000016437/ENSPREG00000009356/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000016797/ENSPREG00000005038/ENSPREG00000014985/ENSPREG00000014803/ENSPREG00000002487/ENSPREG00000012663/ENSPREG00000011942/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000020625/ENSPREG00000001598/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000015905/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000008761/ENSPREG00000017524/ENSPREG00000014826/ENSPREG00000018565/ENSPREG00000008229/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000013651/ENSPREG00000023092/ENSPREG00000011725/ENSPREG00000002365/ENSPREG00000013087/ENSPREG00000019394/ENSPREG00000004768/ENSPREG00000016149/ENSPREG00000022772/ENSPREG00000003481/ENSPREG00000015916/ENSPREG00000014745/ENSPREG00000013420/ENSPREG00000018748/ENSPREG00000015213/ENSPREG00000013694/ENSPREG00000013209/ENSPREG00000013455/ENSPREG00000008785/ENSPREG00000015004/ENSPREG00000002018/ENSPREG00000013775/ENSPREG00000006479/ENSPREG00000009731/ENSPREG00000018100/ENSPREG00000017420/ENSPREG00000012360/ENSPREG00000008939/ENSPREG00000006060/ENSPREG00000004380/ENSPREG00000013995/ENSPREG00000018387/ENSPREG00000016519/ENSPREG00000018881/ENSPREG00000017783/ENSPREG00000022899/ENSPREG00000011721/ENSPREG00000013686/ENSPREG00000011212/ENSPREG00000017575/ENSPREG00000008858/ENSPREG00000015711/ENSPREG00000018486/ENSPREG00000018056/ENSPREG00000004772/ENSPREG00000006969/ENSPREG00000022246/ENSPREG00000006322/ENSPREG00000002822/ENSPREG00000011546/ENSPREG00000019601/ENSPREG00000008698/ENSPREG00000013840/ENSPREG00000011938/ENSPREG00000003572
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000002117/ENSPREG00000011367/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000012188/ENSPREG00000005993/ENSPREG00000013196/ENSPREG00000017440/ENSPREG00000013067/ENSPREG00000010797/ENSPREG00000014049/ENSPREG00000020203/ENSPREG00000018023/ENSPREG00000021630/ENSPREG00000003423/ENSPREG00000012105/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000006796/ENSPREG00000016234/ENSPREG00000015465/ENSPREG00000000568/ENSPREG00000009198/ENSPREG00000015331/ENSPREG00000010656/ENSPREG00000000644/ENSPREG00000006767/ENSPREG00000017524/ENSPREG00000006388/ENSPREG00000017666/ENSPREG00000010954/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000015884/ENSPREG00000015470/ENSPREG00000008500/ENSPREG00000002123/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000013636/ENSPREG00000013353/ENSPREG00000001953/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000014279/ENSPREG00000008300/ENSPREG00000009681/ENSPREG00000013058/ENSPREG00000001340/ENSPREG00000001364/ENSPREG00000020298/ENSPREG00000003001/ENSPREG00000001346/ENSPREG00000006479/ENSPREG00000005343/ENSPREG00000006787/ENSPREG00000010783/ENSPREG00000013048/ENSPREG00000001397/ENSPREG00000008763/ENSPREG00000021719/ENSPREG00000006716/ENSPREG00000019670/ENSPREG00000000683/ENSPREG00000005851/ENSPREG00000017276/ENSPREG00000022983/ENSPREG00000017783/ENSPREG00000020349/ENSPREG00000011721/ENSPREG00000021227/ENSPREG00000013623/ENSPREG00000020505/ENSPREG00000021437/ENSPREG00000011089/ENSPREG00000007900/ENSPREG00000020306/ENSPREG00000021407/ENSPREG00000006276/ENSPREG00000013765/ENSPREG00000021885/ENSPREG00000006772/ENSPREG00000017901/ENSPREG00000006705/ENSPREG00000015810
## GO:0048471 perinuclear region of cytoplasm ENSPREG00000016990/ENSPREG00000017141/ENSPREG00000010615/ENSPREG00000010109/ENSPREG00000022530/ENSPREG00000020209/ENSPREG00000020303/ENSPREG00000017328/ENSPREG00000005255/ENSPREG00000022295/ENSPREG00000017997/ENSPREG00000000501/ENSPREG00000004048/ENSPREG00000002853/ENSPREG00000006901/ENSPREG00000008950/ENSPREG00000007668/ENSPREG00000006397/ENSPREG00000020052
## GO:0015075 ion transmembrane transporter activity ENSPREG00000003778/ENSPREG00000018212/ENSPREG00000005776/ENSPREG00000007011/ENSPREG00000013279/ENSPREG00000013471
## GO:0030513 positive regulation of BMP signaling pathway ENSPREG00000019287/ENSPREG00000000104/ENSPREG00000014903/ENSPREG00000018051/ENSPREG00000020925/ENSPREG00000022947/ENSPREG00000018278/ENSPREG00000006960
## GO:1902476 chloride transmembrane transport ENSPREG00000009136/ENSPREG00000011183/ENSPREG00000011910/ENSPREG00000010288/ENSPREG00000001579/ENSPREG00000001701/ENSPREG00000012121/ENSPREG00000005774
## GO:0003700 DNA-binding transcription factor activity ENSPREG00000021725/ENSPREG00000009351/ENSPREG00000010341/ENSPREG00000012168/ENSPREG00000012367/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000014446/ENSPREG00000012003/ENSPREG00000021982/ENSPREG00000016437/ENSPREG00000013067/ENSPREG00000009356/ENSPREG00000010797/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000009540/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000005038/ENSPREG00000014985/ENSPREG00000018193/ENSPREG00000014803/ENSPREG00000021553/ENSPREG00000022267/ENSPREG00000018746/ENSPREG00000002487/ENSPREG00000009502/ENSPREG00000012663/ENSPREG00000012965/ENSPREG00000014392/ENSPREG00000011942/ENSPREG00000013403/ENSPREG00000011496/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000020625/ENSPREG00000006796/ENSPREG00000001598/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000000512/ENSPREG00000015465/ENSPREG00000000568/ENSPREG00000015905/ENSPREG00000015331/ENSPREG00000001395/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000008761/ENSPREG00000005818/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000001199/ENSPREG00000014826/ENSPREG00000018565/ENSPREG00000016109/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000019842/ENSPREG00000001222/ENSPREG00000006368/ENSPREG00000005136/ENSPREG00000019859/ENSPREG00000013651/ENSPREG00000013766/ENSPREG00000016210/ENSPREG00000015597/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000011725/ENSPREG00000013087/ENSPREG00000021303/ENSPREG00000004757/ENSPREG00000006777/ENSPREG00000004514/ENSPREG00000019394/ENSPREG00000004768/ENSPREG00000004628/ENSPREG00000010182/ENSPREG00000023255/ENSPREG00000016149/ENSPREG00000022772/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000021021/ENSPREG00000015916/ENSPREG00000013636/ENSPREG00000014513/ENSPREG00000020875/ENSPREG00000005380/ENSPREG00000014745/ENSPREG00000012212/ENSPREG00000013420/ENSPREG00000013386/ENSPREG00000018748/ENSPREG00000015854/ENSPREG00000019762/ENSPREG00000013694/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000013058/ENSPREG00000012699/ENSPREG00000021782/ENSPREG00000004079/ENSPREG00000008785/ENSPREG00000020684/ENSPREG00000006621/ENSPREG00000002018/ENSPREG00000013775/ENSPREG00000004743/ENSPREG00000006479/ENSPREG00000019385/ENSPREG00000018224/ENSPREG00000006787/ENSPREG00000009731/ENSPREG00000017420/ENSPREG00000001229/ENSPREG00000008939/ENSPREG00000019278/ENSPREG00000006060/ENSPREG00000004380/ENSPREG00000013995/ENSPREG00000018387/ENSPREG00000016519/ENSPREG00000005851/ENSPREG00000018881/ENSPREG00000022983/ENSPREG00000017783/ENSPREG00000022899/ENSPREG00000011721/ENSPREG00000019546/ENSPREG00000013686/ENSPREG00000011212/ENSPREG00000020505/ENSPREG00000017575/ENSPREG00000019566/ENSPREG00000015711/ENSPREG00000018486/ENSPREG00000004772/ENSPREG00000006969/ENSPREG00000014867/ENSPREG00000019480/ENSPREG00000007900/ENSPREG00000022246/ENSPREG00000017494/ENSPREG00000006322/ENSPREG00000002822/ENSPREG00000021885/ENSPREG00000011546/ENSPREG00000019601/ENSPREG00000011939/ENSPREG00000008698/ENSPREG00000013840/ENSPREG00000001432/ENSPREG00000015810/ENSPREG00000012858/ENSPREG00000011938/ENSPREG00000003572
## GO:0005515 protein binding ENSPREG00000011953/ENSPREG00000003585/ENSPREG00000012853/ENSPREG00000004055/ENSPREG00000006443/ENSPREG00000020958/ENSPREG00000000164/ENSPREG00000002278/ENSPREG00000010544/ENSPREG00000001363/ENSPREG00000022961/ENSPREG00000002771/ENSPREG00000019101/ENSPREG00000016965/ENSPREG00000010341/ENSPREG00000000900/ENSPREG00000001335/ENSPREG00000000954/ENSPREG00000000312/ENSPREG00000007731/ENSPREG00000017981/ENSPREG00000019186/ENSPREG00000010064/ENSPREG00000017574/ENSPREG00000002476/ENSPREG00000021756/ENSPREG00000006662/ENSPREG00000017062/ENSPREG00000005051/ENSPREG00000022512/ENSPREG00000021269/ENSPREG00000017111/ENSPREG00000012251/ENSPREG00000006194/ENSPREG00000010675/ENSPREG00000003508/ENSPREG00000002457/ENSPREG00000018360/ENSPREG00000007359/ENSPREG00000010264/ENSPREG00000001755/ENSPREG00000022133/ENSPREG00000011250/ENSPREG00000009749/ENSPREG00000012218/ENSPREG00000008576/ENSPREG00000012822/ENSPREG00000022786/ENSPREG00000005421/ENSPREG00000015185/ENSPREG00000021217/ENSPREG00000016656/ENSPREG00000007748/ENSPREG00000004777/ENSPREG00000008770/ENSPREG00000022184/ENSPREG00000012394/ENSPREG00000009526/ENSPREG00000004054/ENSPREG00000020009/ENSPREG00000006259/ENSPREG00000004210/ENSPREG00000001857/ENSPREG00000016455/ENSPREG00000016460/ENSPREG00000010850/ENSPREG00000004636/ENSPREG00000006420/ENSPREG00000007238/ENSPREG00000005549/ENSPREG00000022326/ENSPREG00000022339/ENSPREG00000009984/ENSPREG00000006436/ENSPREG00000008019/ENSPREG00000004557/ENSPREG00000015324/ENSPREG00000018900/ENSPREG00000010906/ENSPREG00000003283/ENSPREG00000009016/ENSPREG00000023140/ENSPREG00000017454/ENSPREG00000021256/ENSPREG00000010905/ENSPREG00000005048/ENSPREG00000017448/ENSPREG00000009775/ENSPREG00000014023/ENSPREG00000003639/ENSPREG00000019504/ENSPREG00000020820/ENSPREG00000007778/ENSPREG00000008779/ENSPREG00000001445/ENSPREG00000009816/ENSPREG00000019197/ENSPREG00000001908/ENSPREG00000009568/ENSPREG00000011786/ENSPREG00000018613/ENSPREG00000021359/ENSPREG00000001707/ENSPREG00000014502/ENSPREG00000018480/ENSPREG00000003918/ENSPREG00000013331/ENSPREG00000015652/ENSPREG00000021494/ENSPREG00000018963/ENSPREG00000000685/ENSPREG00000011284/ENSPREG00000017061/ENSPREG00000006987/ENSPREG00000011331/ENSPREG00000003791/ENSPREG00000006498/ENSPREG00000013511/ENSPREG00000009287/ENSPREG00000020745/ENSPREG00000008863/ENSPREG00000014625/ENSPREG00000014332/ENSPREG00000008038/ENSPREG00000020473/ENSPREG00000022076/ENSPREG00000001939/ENSPREG00000022874/ENSPREG00000000609/ENSPREG00000012617/ENSPREG00000018667/ENSPREG00000004060/ENSPREG00000009991/ENSPREG00000012897/ENSPREG00000020768/ENSPREG00000000778/ENSPREG00000013339/ENSPREG00000016039/ENSPREG00000020999/ENSPREG00000013249/ENSPREG00000006035/ENSPREG00000022557/ENSPREG00000016525/ENSPREG00000022193/ENSPREG00000016649/ENSPREG00000016742/ENSPREG00000020310/ENSPREG00000019287/ENSPREG00000008034/ENSPREG00000020020/ENSPREG00000020573/ENSPREG00000018579/ENSPREG00000006914/ENSPREG00000018739/ENSPREG00000021915/ENSPREG00000009226/ENSPREG00000020590/ENSPREG00000003437/ENSPREG00000013858/ENSPREG00000001868/ENSPREG00000008052/ENSPREG00000017326/ENSPREG00000016063/ENSPREG00000009689/ENSPREG00000018193/ENSPREG00000017413/ENSPREG00000015614/ENSPREG00000008848/ENSPREG00000004374/ENSPREG00000009970/ENSPREG00000000119/ENSPREG00000021215/ENSPREG00000011322/ENSPREG00000006634/ENSPREG00000016838/ENSPREG00000004773/ENSPREG00000002585/ENSPREG00000012167/ENSPREG00000021481/ENSPREG00000014507/ENSPREG00000019656/ENSPREG00000018652/ENSPREG00000019132/ENSPREG00000010109/ENSPREG00000002194/ENSPREG00000018925/ENSPREG00000022191/ENSPREG00000010877/ENSPREG00000004259/ENSPREG00000017070/ENSPREG00000001142/ENSPREG00000004300/ENSPREG00000010225/ENSPREG00000010503/ENSPREG00000013653/ENSPREG00000005178/ENSPREG00000018468/ENSPREG00000014793/ENSPREG00000015578/ENSPREG00000017867/ENSPREG00000022029/ENSPREG00000018630/ENSPREG00000003604/ENSPREG00000002248/ENSPREG00000000125/ENSPREG00000020067/ENSPREG00000002348/ENSPREG00000017042/ENSPREG00000013496/ENSPREG00000012534/ENSPREG00000010160/ENSPREG00000021797/ENSPREG00000013675/ENSPREG00000015865/ENSPREG00000007974/ENSPREG00000019086/ENSPREG00000006294/ENSPREG00000014092/ENSPREG00000006797/ENSPREG00000007324/ENSPREG00000013327/ENSPREG00000010833/ENSPREG00000016362/ENSPREG00000004312/ENSPREG00000022420/ENSPREG00000012550/ENSPREG00000022289/ENSPREG00000016312/ENSPREG00000020729/ENSPREG00000002145/ENSPREG00000019855/ENSPREG00000001211/ENSPREG00000007903/ENSPREG00000004039/ENSPREG00000003645/ENSPREG00000016756/ENSPREG00000015315/ENSPREG00000020923/ENSPREG00000019248/ENSPREG00000022372/ENSPREG00000017615/ENSPREG00000013611/ENSPREG00000003891/ENSPREG00000015801/ENSPREG00000003542/ENSPREG00000021106/ENSPREG00000003558/ENSPREG00000010978/ENSPREG00000004149/ENSPREG00000017179/ENSPREG00000008818/ENSPREG00000014516/ENSPREG00000006673/ENSPREG00000010595/ENSPREG00000015791/ENSPREG00000006962/ENSPREG00000021539/ENSPREG00000010337/ENSPREG00000001779/ENSPREG00000007565/ENSPREG00000007331/ENSPREG00000014483/ENSPREG00000007218/ENSPREG00000021575/ENSPREG00000005611/ENSPREG00000000341/ENSPREG00000000779/ENSPREG00000017751/ENSPREG00000018891/ENSPREG00000017444/ENSPREG00000002366/ENSPREG00000015258/ENSPREG00000019319/ENSPREG00000011127/ENSPREG00000016459/ENSPREG00000012958/ENSPREG00000000598/ENSPREG00000007319/ENSPREG00000000130/ENSPREG00000018168/ENSPREG00000023130/ENSPREG00000003538/ENSPREG00000010253/ENSPREG00000009748/ENSPREG00000018357/ENSPREG00000020450/ENSPREG00000002792/ENSPREG00000003800/ENSPREG00000016483/ENSPREG00000006438/ENSPREG00000012231/ENSPREG00000016682/ENSPREG00000018477/ENSPREG00000000498/ENSPREG00000017820/ENSPREG00000012402/ENSPREG00000015306/ENSPREG00000003789/ENSPREG00000007632/ENSPREG00000002536/ENSPREG00000007006/ENSPREG00000015905/ENSPREG00000022828/ENSPREG00000001070/ENSPREG00000013271/ENSPREG00000006403/ENSPREG00000004343/ENSPREG00000020515/ENSPREG00000012225/ENSPREG00000013733/ENSPREG00000017328/ENSPREG00000014807/ENSPREG00000016967/ENSPREG00000013044/ENSPREG00000019090/ENSPREG00000004228/ENSPREG00000022838/ENSPREG00000019860/ENSPREG00000003161/ENSPREG00000018661/ENSPREG00000017365/ENSPREG00000019790/ENSPREG00000002917/ENSPREG00000019982/ENSPREG00000000629/ENSPREG00000006781/ENSPREG00000003290/ENSPREG00000020137/ENSPREG00000002735/ENSPREG00000018854/ENSPREG00000007262/ENSPREG00000004021/ENSPREG00000000588/ENSPREG00000000485/ENSPREG00000004632/ENSPREG00000019282/ENSPREG00000017951/ENSPREG00000020325/ENSPREG00000010697/ENSPREG00000009084/ENSPREG00000016523/ENSPREG00000008775/ENSPREG00000008786/ENSPREG00000007493/ENSPREG00000005420/ENSPREG00000022223/ENSPREG00000003169/ENSPREG00000009811/ENSPREG00000002766/ENSPREG00000022877/ENSPREG00000013687/ENSPREG00000018567/ENSPREG00000018440/ENSPREG00000008123/ENSPREG00000016650/ENSPREG00000016750/ENSPREG00000018609/ENSPREG00000020959/ENSPREG00000001407/ENSPREG00000019707/ENSPREG00000007789/ENSPREG00000009060/ENSPREG00000021856/ENSPREG00000020680/ENSPREG00000009420/ENSPREG00000018413/ENSPREG00000010270/ENSPREG00000014937/ENSPREG00000018664/ENSPREG00000010883/ENSPREG00000015764/ENSPREG00000018397/ENSPREG00000014672/ENSPREG00000007053/ENSPREG00000011196/ENSPREG00000015338/ENSPREG00000013074/ENSPREG00000020439/ENSPREG00000015075/ENSPREG00000019585/ENSPREG00000015346/ENSPREG00000016331/ENSPREG00000001436/ENSPREG00000011068/ENSPREG00000006820/ENSPREG00000001060/ENSPREG00000011431/ENSPREG00000011949/ENSPREG00000021865/ENSPREG00000012273/ENSPREG00000002972/ENSPREG00000014047/ENSPREG00000004576/ENSPREG00000006212/ENSPREG00000021455/ENSPREG00000022197/ENSPREG00000021205/ENSPREG00000022224/ENSPREG00000010089/ENSPREG00000001752/ENSPREG00000003965/ENSPREG00000002677/ENSPREG00000001500/ENSPREG00000009177/ENSPREG00000020822/ENSPREG00000008369/ENSPREG00000014973/ENSPREG00000018382/ENSPREG00000001103/ENSPREG00000002254/ENSPREG00000018823/ENSPREG00000006544/ENSPREG00000017366/ENSPREG00000010853/ENSPREG00000010858/ENSPREG00000022805/ENSPREG00000010817/ENSPREG00000011132/ENSPREG00000006025/ENSPREG00000005148/ENSPREG00000019039/ENSPREG00000005192/ENSPREG00000022668/ENSPREG00000013763/ENSPREG00000018266/ENSPREG00000017085/ENSPREG00000017018/ENSPREG00000015714/ENSPREG00000016542/ENSPREG00000001716/ENSPREG00000010039/ENSPREG00000012552/ENSPREG00000003515/ENSPREG00000014312/ENSPREG00000020669/ENSPREG00000018452/ENSPREG00000012989/ENSPREG00000018366/ENSPREG00000021218/ENSPREG00000015597/ENSPREG00000018361/ENSPREG00000014068/ENSPREG00000000638/ENSPREG00000000041/ENSPREG00000018926/ENSPREG00000006387/ENSPREG00000021765/ENSPREG00000011036/ENSPREG00000007582/ENSPREG00000002613/ENSPREG00000014065/ENSPREG00000009142/ENSPREG00000021158/ENSPREG00000007156/ENSPREG00000016621/ENSPREG00000018675/ENSPREG00000021550/ENSPREG00000022746/ENSPREG00000015956/ENSPREG00000004073/ENSPREG00000016118/ENSPREG00000018291/ENSPREG00000005026/ENSPREG00000006669/ENSPREG00000023229/ENSPREG00000023230/ENSPREG00000010400/ENSPREG00000021766/ENSPREG00000019394/ENSPREG00000005952/ENSPREG00000018173/ENSPREG00000011959/ENSPREG00000011957/ENSPREG00000010712/ENSPREG00000002171/ENSPREG00000003313/ENSPREG00000000688/ENSPREG00000001809/ENSPREG00000008648/ENSPREG00000004565/ENSPREG00000010345/ENSPREG00000005875/ENSPREG00000003677/ENSPREG00000018877/ENSPREG00000014041/ENSPREG00000018764/ENSPREG00000019858/ENSPREG00000017741/ENSPREG00000023155/ENSPREG00000001257/ENSPREG00000004963/ENSPREG00000021439/ENSPREG00000022257/ENSPREG00000023048/ENSPREG00000021901/ENSPREG00000003852/ENSPREG00000000473/ENSPREG00000009614/ENSPREG00000022808/ENSPREG00000011946/ENSPREG00000004067/ENSPREG00000018109/ENSPREG00000004566/ENSPREG00000011365/ENSPREG00000019135/ENSPREG00000015843/ENSPREG00000012147/ENSPREG00000021731/ENSPREG00000002598/ENSPREG00000022344/ENSPREG00000010201/ENSPREG00000000237/ENSPREG00000008086/ENSPREG00000009992/ENSPREG00000010914/ENSPREG00000022132/ENSPREG00000004587/ENSPREG00000011776/ENSPREG00000000802/ENSPREG00000000860/ENSPREG00000002240/ENSPREG00000021179/ENSPREG00000021917/ENSPREG00000001918/ENSPREG00000003732/ENSPREG00000001091/ENSPREG00000014903/ENSPREG00000018329/ENSPREG00000015691/ENSPREG00000021634/ENSPREG00000021653/ENSPREG00000012615/ENSPREG00000010979/ENSPREG00000022506/ENSPREG00000008410/ENSPREG00000022413/ENSPREG00000007226/ENSPREG00000015203/ENSPREG00000019686/ENSPREG00000021438/ENSPREG00000015181/ENSPREG00000015724/ENSPREG00000005185/ENSPREG00000015048/ENSPREG00000003556/ENSPREG00000015829/ENSPREG00000003150/ENSPREG00000004187/ENSPREG00000023222/ENSPREG00000002029/ENSPREG00000015925/ENSPREG00000005556/ENSPREG00000014079/ENSPREG00000019833/ENSPREG00000013019/ENSPREG00000004711/ENSPREG00000015447/ENSPREG00000020410/ENSPREG00000017655/ENSPREG00000009378/ENSPREG00000006391/ENSPREG00000021927/ENSPREG00000011314/ENSPREG00000010543/ENSPREG00000023076/ENSPREG00000010790/ENSPREG00000005355/ENSPREG00000010742/ENSPREG00000015049/ENSPREG00000004424/ENSPREG00000013078/ENSPREG00000007271/ENSPREG00000004106/ENSPREG00000021275/ENSPREG00000006188/ENSPREG00000019244/ENSPREG00000011544/ENSPREG00000009537/ENSPREG00000010315/ENSPREG00000005211/ENSPREG00000001419/ENSPREG00000017121/ENSPREG00000018231/ENSPREG00000008155/ENSPREG00000003728/ENSPREG00000012212/ENSPREG00000009864/ENSPREG00000013262/ENSPREG00000001690/ENSPREG00000008737/ENSPREG00000021811/ENSPREG00000011213/ENSPREG00000022505/ENSPREG00000009745/ENSPREG00000006354/ENSPREG00000001415/ENSPREG00000016753/ENSPREG00000000681/ENSPREG00000017705/ENSPREG00000021213/ENSPREG00000005053/ENSPREG00000019089/ENSPREG00000004560/ENSPREG00000011179/ENSPREG00000011758/ENSPREG00000015467/ENSPREG00000011701/ENSPREG00000017329/ENSPREG00000015671/ENSPREG00000008982/ENSPREG00000021573/ENSPREG00000013344/ENSPREG00000011050/ENSPREG00000000279/ENSPREG00000016036/ENSPREG00000008915/ENSPREG00000007092/ENSPREG00000004354/ENSPREG00000021545/ENSPREG00000002074/ENSPREG00000011176/ENSPREG00000020693/ENSPREG00000014100/ENSPREG00000012528/ENSPREG00000006028/ENSPREG00000019567/ENSPREG00000008224/ENSPREG00000015236/ENSPREG00000004796/ENSPREG00000002489/ENSPREG00000002834/ENSPREG00000003121/ENSPREG00000004375/ENSPREG00000018352/ENSPREG00000012811/ENSPREG00000020457/ENSPREG00000017408/ENSPREG00000022386/ENSPREG00000018426/ENSPREG00000014992/ENSPREG00000007309/ENSPREG00000019505/ENSPREG00000018879/ENSPREG00000009870/ENSPREG00000021150/ENSPREG00000012699/ENSPREG00000009248/ENSPREG00000015672/ENSPREG00000016215/ENSPREG00000020147/ENSPREG00000000217/ENSPREG00000007516/ENSPREG00000014772/ENSPREG00000004722/ENSPREG00000014260/ENSPREG00000019594/ENSPREG00000012037/ENSPREG00000013300/ENSPREG00000021009/ENSPREG00000018533/ENSPREG00000022222/ENSPREG00000015288/ENSPREG00000015988/ENSPREG00000021066/ENSPREG00000007785/ENSPREG00000004754/ENSPREG00000022687/ENSPREG00000012783/ENSPREG00000015074/ENSPREG00000021291/ENSPREG00000002035/ENSPREG00000022641/ENSPREG00000011567/ENSPREG00000010172/ENSPREG00000001482/ENSPREG00000004150/ENSPREG00000021638/ENSPREG00000018430/ENSPREG00000000581/ENSPREG00000000589/ENSPREG00000012430/ENSPREG00000020891/ENSPREG00000018815/ENSPREG00000014790/ENSPREG00000012361/ENSPREG00000004700/ENSPREG00000002362/ENSPREG00000020660/ENSPREG00000020749/ENSPREG00000017038/ENSPREG00000004874/ENSPREG00000017608/ENSPREG00000005525/ENSPREG00000002472/ENSPREG00000022353/ENSPREG00000005289/ENSPREG00000003601/ENSPREG00000003584/ENSPREG00000002203/ENSPREG00000010965/ENSPREG00000020970/ENSPREG00000015822/ENSPREG00000000107/ENSPREG00000018410/ENSPREG00000022933/ENSPREG00000012566/ENSPREG00000021620/ENSPREG00000021425/ENSPREG00000005590/ENSPREG00000016104/ENSPREG00000014040/ENSPREG00000020493/ENSPREG00000007793/ENSPREG00000016174/ENSPREG00000007852/ENSPREG00000007468/ENSPREG00000002908/ENSPREG00000001286/ENSPREG00000008665/ENSPREG00000001239/ENSPREG00000019151/ENSPREG00000007039/ENSPREG00000018073/ENSPREG00000015138/ENSPREG00000005463/ENSPREG00000007711/ENSPREG00000012133/ENSPREG00000021435/ENSPREG00000022493/ENSPREG00000019273/ENSPREG00000005614/ENSPREG00000005687/ENSPREG00000020654/ENSPREG00000016333/ENSPREG00000015265/ENSPREG00000006193/ENSPREG00000022876/ENSPREG00000014591/ENSPREG00000013118/ENSPREG00000019390/ENSPREG00000019034/ENSPREG00000018987/ENSPREG00000002183/ENSPREG00000012276/ENSPREG00000018531/ENSPREG00000011954/ENSPREG00000006834/ENSPREG00000016100/ENSPREG00000016138/ENSPREG00000010157/ENSPREG00000008798/ENSPREG00000004552/ENSPREG00000017699/ENSPREG00000017770/ENSPREG00000005156/ENSPREG00000020859/ENSPREG00000005163/ENSPREG00000012360/ENSPREG00000002971/ENSPREG00000018185/ENSPREG00000006253/ENSPREG00000006918/ENSPREG00000003963/ENSPREG00000011185/ENSPREG00000005208/ENSPREG00000007423/ENSPREG00000019550/ENSPREG00000010863/ENSPREG00000009732/ENSPREG00000012815/ENSPREG00000008054/ENSPREG00000000375/ENSPREG00000020390/ENSPREG00000020727/ENSPREG00000000452/ENSPREG00000001702/ENSPREG00000003104/ENSPREG00000001247/ENSPREG00000022921/ENSPREG00000010771/ENSPREG00000021138/ENSPREG00000019278/ENSPREG00000014744/ENSPREG00000002936/ENSPREG00000014739/ENSPREG00000006060/ENSPREG00000000191/ENSPREG00000015935/ENSPREG00000010318/ENSPREG00000006218/ENSPREG00000004946/ENSPREG00000004221/ENSPREG00000012500/ENSPREG00000017120/ENSPREG00000006840/ENSPREG00000010056/ENSPREG00000007868/ENSPREG00000001741/ENSPREG00000008623/ENSPREG00000004944/ENSPREG00000021889/ENSPREG00000019283/ENSPREG00000003411/ENSPREG00000022172/ENSPREG00000013942/ENSPREG00000005237/ENSPREG00000021613/ENSPREG00000010169/ENSPREG00000021411/ENSPREG00000001810/ENSPREG00000008367/ENSPREG00000004018/ENSPREG00000016489/ENSPREG00000000752/ENSPREG00000006590/ENSPREG00000000770/ENSPREG00000015859/ENSPREG00000008742/ENSPREG00000019661/ENSPREG00000002380/ENSPREG00000018726/ENSPREG00000008141/ENSPREG00000022577/ENSPREG00000019866/ENSPREG00000004250/ENSPREG00000007668/ENSPREG00000022708/ENSPREG00000020814/ENSPREG00000017801/ENSPREG00000020634/ENSPREG00000008562/ENSPREG00000009307/ENSPREG00000009642/ENSPREG00000021395/ENSPREG00000005315/ENSPREG00000016402/ENSPREG00000017727/ENSPREG00000018540/ENSPREG00000021349/ENSPREG00000013460/ENSPREG00000017407/ENSPREG00000012526/ENSPREG00000002006/ENSPREG00000018390/ENSPREG00000014349/ENSPREG00000010051/ENSPREG00000015340/ENSPREG00000010066/ENSPREG00000000704/ENSPREG00000019675/ENSPREG00000018881/ENSPREG00000010346/ENSPREG00000009088/ENSPREG00000013038/ENSPREG00000019630/ENSPREG00000005541/ENSPREG00000000181/ENSPREG00000022182/ENSPREG00000010443/ENSPREG00000002716/ENSPREG00000017034/ENSPREG00000015301/ENSPREG00000011191/ENSPREG00000006129/ENSPREG00000010720/ENSPREG00000014024/ENSPREG00000005229/ENSPREG00000014454/ENSPREG00000017079/ENSPREG00000015679/ENSPREG00000006711/ENSPREG00000007579/ENSPREG00000021458/ENSPREG00000013872/ENSPREG00000003502/ENSPREG00000011589/ENSPREG00000016757/ENSPREG00000004494/ENSPREG00000010198/ENSPREG00000009239/ENSPREG00000022086/ENSPREG00000020548/ENSPREG00000017143/ENSPREG00000015073/ENSPREG00000022200/ENSPREG00000007756/ENSPREG00000002137/ENSPREG00000012267/ENSPREG00000023057/ENSPREG00000010674/ENSPREG00000011489/ENSPREG00000005665/ENSPREG00000013491/ENSPREG00000004903/ENSPREG00000013392/ENSPREG00000015114/ENSPREG00000022278/ENSPREG00000003282/ENSPREG00000002547/ENSPREG00000004224/ENSPREG00000020089/ENSPREG00000005896/ENSPREG00000011094/ENSPREG00000021437/ENSPREG00000008228/ENSPREG00000022830/ENSPREG00000018047/ENSPREG00000006207/ENSPREG00000013014/ENSPREG00000010921/ENSPREG00000012104/ENSPREG00000006738/ENSPREG00000013899/ENSPREG00000020791/ENSPREG00000014916/ENSPREG00000017575/ENSPREG00000011097/ENSPREG00000017552/ENSPREG00000000819/ENSPREG00000018707/ENSPREG00000022755/ENSPREG00000011027/ENSPREG00000008451/ENSPREG00000013110/ENSPREG00000015532/ENSPREG00000006089/ENSPREG00000013966/ENSPREG00000001319/ENSPREG00000011769/ENSPREG00000013046/ENSPREG00000010347/ENSPREG00000020818/ENSPREG00000020271/ENSPREG00000012860/ENSPREG00000015825/ENSPREG00000003389/ENSPREG00000004360/ENSPREG00000000234/ENSPREG00000016474/ENSPREG00000014906/ENSPREG00000022895/ENSPREG00000020784/ENSPREG00000018807/ENSPREG00000018348/ENSPREG00000004929/ENSPREG00000011636/ENSPREG00000009630/ENSPREG00000008242/ENSPREG00000003662/ENSPREG00000022622/ENSPREG00000010585/ENSPREG00000019499/ENSPREG00000007539/ENSPREG00000003105/ENSPREG00000005893/ENSPREG00000007761/ENSPREG00000013162/ENSPREG00000010808/ENSPREG00000015887/ENSPREG00000023141/ENSPREG00000007301/ENSPREG00000011541/ENSPREG00000022741/ENSPREG00000000060/ENSPREG00000003143/ENSPREG00000018865/ENSPREG00000013503/ENSPREG00000006365/ENSPREG00000011207/ENSPREG00000023022/ENSPREG00000001437/ENSPREG00000011972/ENSPREG00000015991/ENSPREG00000010793/ENSPREG00000007157/ENSPREG00000008917/ENSPREG00000019255/ENSPREG00000005850/ENSPREG00000020808/ENSPREG00000009885/ENSPREG00000020595/ENSPREG00000008974/ENSPREG00000000238/ENSPREG00000009123/ENSPREG00000014636/ENSPREG00000014852/ENSPREG00000019297/ENSPREG00000003995/ENSPREG00000022213/ENSPREG00000019203/ENSPREG00000008195/ENSPREG00000016724/ENSPREG00000005662/ENSPREG00000005671/ENSPREG00000021850/ENSPREG00000011537/ENSPREG00000021406/ENSPREG00000021750/ENSPREG00000019054/ENSPREG00000005812/ENSPREG00000015405/ENSPREG00000014612/ENSPREG00000008883/ENSPREG00000013631/ENSPREG00000014283/ENSPREG00000014924/ENSPREG00000017900/ENSPREG00000021017/ENSPREG00000006779/ENSPREG00000000980/ENSPREG00000013873/ENSPREG00000021491/ENSPREG00000017641/ENSPREG00000014968/ENSPREG00000008676/ENSPREG00000017389/ENSPREG00000014779/ENSPREG00000012120/ENSPREG00000009412/ENSPREG00000013129/ENSPREG00000014823/ENSPREG00000012408/ENSPREG00000018845/ENSPREG00000013955/ENSPREG00000007496/ENSPREG00000001985/ENSPREG00000013115/ENSPREG00000019669/ENSPREG00000022970/ENSPREG00000002327/ENSPREG00000002370/ENSPREG00000002212/ENSPREG00000015244/ENSPREG00000003120/ENSPREG00000006473/ENSPREG00000018632/ENSPREG00000020849/ENSPREG00000002840/ENSPREG00000020125/ENSPREG00000014921/ENSPREG00000011271/ENSPREG00000018511/ENSPREG00000003008/ENSPREG00000015735/ENSPREG00000003361/ENSPREG00000021255/ENSPREG00000002204/ENSPREG00000019965/ENSPREG00000021145/ENSPREG00000011881/ENSPREG00000003309/ENSPREG00000016861/ENSPREG00000007602/ENSPREG00000004335/ENSPREG00000006747/ENSPREG00000000345/ENSPREG00000002215/ENSPREG00000017512/ENSPREG00000015440/ENSPREG00000015428/ENSPREG00000009791/ENSPREG00000002967/ENSPREG00000016699/ENSPREG00000023219/ENSPREG00000019152/ENSPREG00000007744/ENSPREG00000019701/ENSPREG00000014399/ENSPREG00000019792/ENSPREG00000018522/ENSPREG00000009969/ENSPREG00000018499/ENSPREG00000015234/ENSPREG00000007821/ENSPREG00000005933/ENSPREG00000020914/ENSPREG00000006078/ENSPREG00000013539/ENSPREG00000022260/ENSPREG00000003102/ENSPREG00000002408/ENSPREG00000002891/ENSPREG00000006378/ENSPREG00000004459/ENSPREG00000008178/ENSPREG00000002290/ENSPREG00000013085/ENSPREG00000005173/ENSPREG00000020771/ENSPREG00000015436/ENSPREG00000019745/ENSPREG00000010589/ENSPREG00000001330/ENSPREG00000017063/ENSPREG00000022695/ENSPREG00000007082/ENSPREG00000022710/ENSPREG00000019331/ENSPREG00000003359
## GO:0009887 animal organ morphogenesis ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000006008/ENSPREG00000001620/ENSPREG00000013898/ENSPREG00000011725/ENSPREG00000014489/ENSPREG00000004048/ENSPREG00000008317
## GO:0006355 regulation of transcription, DNA-templated ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000009351/ENSPREG00000010804/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000012367/ENSPREG00000002117/ENSPREG00000005028/ENSPREG00000006450/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000015529/ENSPREG00000012188/ENSPREG00000014446/ENSPREG00000013196/ENSPREG00000012003/ENSPREG00000018974/ENSPREG00000017440/ENSPREG00000021982/ENSPREG00000003428/ENSPREG00000016437/ENSPREG00000018613/ENSPREG00000003918/ENSPREG00000008997/ENSPREG00000013067/ENSPREG00000015542/ENSPREG00000009356/ENSPREG00000010797/ENSPREG00000017870/ENSPREG00000009964/ENSPREG00000023148/ENSPREG00000003440/ENSPREG00000009540/ENSPREG00000022365/ENSPREG00000014049/ENSPREG00000022317/ENSPREG00000016797/ENSPREG00000020203/ENSPREG00000005038/ENSPREG00000014985/ENSPREG00000018023/ENSPREG00000018193/ENSPREG00000021630/ENSPREG00000021362/ENSPREG00000014803/ENSPREG00000021553/ENSPREG00000022267/ENSPREG00000010581/ENSPREG00000007784/ENSPREG00000018925/ENSPREG00000003423/ENSPREG00000010877/ENSPREG00000019519/ENSPREG00000018746/ENSPREG00000009131/ENSPREG00000002487/ENSPREG00000012663/ENSPREG00000012105/ENSPREG00000012965/ENSPREG00000000531/ENSPREG00000000532/ENSPREG00000014392/ENSPREG00000008402/ENSPREG00000011942/ENSPREG00000013403/ENSPREG00000011496/ENSPREG00000007498/ENSPREG00000019795/ENSPREG00000013601/ENSPREG00000014440/ENSPREG00000020625/ENSPREG00000000691/ENSPREG00000006796/ENSPREG00000001598/ENSPREG00000021365/ENSPREG00000016234/ENSPREG00000015677/ENSPREG00000004185/ENSPREG00000000512/ENSPREG00000015465/ENSPREG00000015395/ENSPREG00000000568/ENSPREG00000015981/ENSPREG00000009198/ENSPREG00000018196/ENSPREG00000015905/ENSPREG00000008337/ENSPREG00000015331/ENSPREG00000001395/ENSPREG00000005288/ENSPREG00000020466/ENSPREG00000017365/ENSPREG00000010656/ENSPREG00000010895/ENSPREG00000011231/ENSPREG00000000644/ENSPREG00000008761/ENSPREG00000006606/ENSPREG00000005818/ENSPREG00000000662/ENSPREG00000012055/ENSPREG00000006767/ENSPREG00000021835/ENSPREG00000005356/ENSPREG00000001199/ENSPREG00000014826/ENSPREG00000018565/ENSPREG00000006388/ENSPREG00000016109/ENSPREG00000023206/ENSPREG00000000694/ENSPREG00000022906/ENSPREG00000022457/ENSPREG00000019842/ENSPREG00000001222/ENSPREG00000013848/ENSPREG00000006544/ENSPREG00000017666/ENSPREG00000012420/ENSPREG00000005374/ENSPREG00000006368/ENSPREG00000019859/ENSPREG00000010250/ENSPREG00000013651/ENSPREG00000013766/ENSPREG00000018366/ENSPREG00000016210/ENSPREG00000015597/ENSPREG00000023092/ENSPREG00000011229/ENSPREG00000016918/ENSPREG00000013087/ENSPREG00000006777/ENSPREG00000019836/ENSPREG00000004514/ENSPREG00000015884/ENSPREG00000004768/ENSPREG00000011959/ENSPREG00000004628/ENSPREG00000010182/ENSPREG00000023255/ENSPREG00000015470/ENSPREG00000020853/ENSPREG00000008500/ENSPREG00000016149/ENSPREG00000022772/ENSPREG00000018399/ENSPREG00000002123/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000023222/ENSPREG00000015916/ENSPREG00000013636/ENSPREG00000014960/ENSPREG00000013353/ENSPREG00000014513/ENSPREG00000001953/ENSPREG00000011544/ENSPREG00000020875/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000014745/ENSPREG00000013420/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000013386/ENSPREG00000018748/ENSPREG00000015213/ENSPREG00000014279/ENSPREG00000015854/ENSPREG00000018134/ENSPREG00000008300/ENSPREG00000008224/ENSPREG00000019762/ENSPREG00000013694/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000013455/ENSPREG00000003743/ENSPREG00000013058/ENSPREG00000012699/ENSPREG00000011922/ENSPREG00000021782/ENSPREG00000004079/ENSPREG00000001340/ENSPREG00000008785/ENSPREG00000020684/ENSPREG00000022546/ENSPREG00000001364/ENSPREG00000020298/ENSPREG00000002018/ENSPREG00000013775/ENSPREG00000003001/ENSPREG00000001346/ENSPREG00000004743/ENSPREG00000007793/ENSPREG00000006479/ENSPREG00000005343/ENSPREG00000019385/ENSPREG00000018224/ENSPREG00000014517/ENSPREG00000006787/ENSPREG00000008483/ENSPREG00000009731/ENSPREG00000002355/ENSPREG00000010783/ENSPREG00000013048/ENSPREG00000018100/ENSPREG00000001397/ENSPREG00000017420/ENSPREG00000001229/ENSPREG00000008939/ENSPREG00000019550/ENSPREG00000002262/ENSPREG00000019278/ENSPREG00000023202/ENSPREG00000021719/ENSPREG00000004380/ENSPREG00000003447/ENSPREG00000009008/ENSPREG00000009240/ENSPREG00000001810/ENSPREG00000006716/ENSPREG00000016928/ENSPREG00000013995/ENSPREG00000018249/ENSPREG00000019148/ENSPREG00000018387/ENSPREG00000019670/ENSPREG00000016361/ENSPREG00000016519/ENSPREG00000000683/ENSPREG00000005851/ENSPREG00000018881/ENSPREG00000022182/ENSPREG00000022983/ENSPREG00000017783/ENSPREG00000020349/ENSPREG00000006129/ENSPREG00000020804/ENSPREG00000022899/ENSPREG00000011721/ENSPREG00000019546/ENSPREG00000004398/ENSPREG00000013686/ENSPREG00000007997/ENSPREG00000021227/ENSPREG00000013623/ENSPREG00000011212/ENSPREG00000020505/ENSPREG00000021437/ENSPREG00000017575/ENSPREG00000019566/ENSPREG00000008858/ENSPREG00000015711/ENSPREG00000018486/ENSPREG00000018056/ENSPREG00000004772/ENSPREG00000008242/ENSPREG00000011089/ENSPREG00000014867/ENSPREG00000005893/ENSPREG00000019480/ENSPREG00000007900/ENSPREG00000010841/ENSPREG00000022246/ENSPREG00000020306/ENSPREG00000021407/ENSPREG00000017494/ENSPREG00000006276/ENSPREG00000006322/ENSPREG00000002822/ENSPREG00000021885/ENSPREG00000006772/ENSPREG00000011546/ENSPREG00000014823/ENSPREG00000017901/ENSPREG00000019601/ENSPREG00000013955/ENSPREG00000011939/ENSPREG00000008698/ENSPREG00000013840/ENSPREG00000001432/ENSPREG00000006705/ENSPREG00000015810/ENSPREG00000012858/ENSPREG00000011938/ENSPREG00000014784/ENSPREG00000003572
## GO:0006885 regulation of pH ENSPREG00000008555/ENSPREG00000001326/ENSPREG00000006390/ENSPREG00000015476/ENSPREG00000018068/ENSPREG00000017526/ENSPREG00000009025/ENSPREG00000006340
## GO:0009190 cyclic nucleotide biosynthetic process ENSPREG00000020922/ENSPREG00000007721/ENSPREG00000009430/ENSPREG00000017629/ENSPREG00000008753/ENSPREG00000018460/ENSPREG00000005428/ENSPREG00000020297/ENSPREG00000002322/ENSPREG00000000314/ENSPREG00000011307/ENSPREG00000010260/ENSPREG00000007085/ENSPREG00000015357/ENSPREG00000009486/ENSPREG00000011289
## Count
## GO:0003677 DNA binding 402
## GO:0007275 multicellular organism development 184
## GO:0005634 nucleus 716
## GO:0043565 sequence-specific DNA binding 91
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 103
## GO:0048471 perinuclear region of cytoplasm 19
## GO:0015075 ion transmembrane transporter activity 6
## GO:0030513 positive regulation of BMP signaling pathway 8
## GO:1902476 chloride transmembrane transport 8
## GO:0003700 DNA-binding transcription factor activity 167
## GO:0005515 protein binding 1099
## GO:0009887 animal organ morphogenesis 9
## GO:0006355 regulation of transcription, DNA-templated 300
## GO:0006885 regulation of pH 8
## GO:0009190 cyclic nucleotide biosynthetic process 16library(reshape2)
CvL_up <- subset(CvL,meth.diff>0&qvalue<0.001)
CvL_up <- unique(CvL_up$gene_id)
str(CvL_up)## chr [1:541] "ENSPREG00000003617" "ENSPREG00000008406" "ENSPREG00000011953" ...CvL_dn <- subset(CvL,meth.diff<0&qvalue<0.001)
CvL_dn <- unique(CvL_dn$gene_id)
str(CvL_dn)## chr [1:763] "ENSPREG00000014846" "ENSPREG00000010182" "ENSPREG00000012722" ...CvG_bg <- unique(CvL$gene_id)
str(CvL_bg)## chr [1:21581] "ENSPREG00000014846" "ENSPREG00000003617" ...c_up <- enricher(gene = CvL_up, universe = CvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_up,15)## ID
## GO:0001556 oocyte maturation GO:0001556 oocyte maturation
## GO:0030318 melanocyte differentiation GO:0030318 melanocyte differentiation
## GO:0005938 cell cortex GO:0005938 cell cortex
## GO:0001558 regulation of cell growth GO:0001558 regulation of cell growth
## GO:0032559 adenyl ribonucleotide binding GO:0032559 adenyl ribonucleotide binding
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0006306 DNA methylation GO:0006306 DNA methylation
## GO:0021794 thalamus development GO:0021794 thalamus development
## GO:0035778 pronephric nephron tubule epithelial cell differentiation GO:0035778 pronephric nephron tubule epithelial cell differentiation
## GO:0071425 hematopoietic stem cell proliferation GO:0071425 hematopoietic stem cell proliferation
## GO:0000139 Golgi membrane GO:0000139 Golgi membrane
## GO:0007030 Golgi organization GO:0007030 Golgi organization
## GO:0043066 negative regulation of apoptotic process GO:0043066 negative regulation of apoptotic process
## GO:0004703 G protein-coupled receptor kinase activity GO:0004703 G protein-coupled receptor kinase activity
## GO:0045746 negative regulation of Notch signaling pathway GO:0045746 negative regulation of Notch signaling pathway
## Description
## GO:0001556 oocyte maturation GO:0001556 oocyte maturation
## GO:0030318 melanocyte differentiation GO:0030318 melanocyte differentiation
## GO:0005938 cell cortex GO:0005938 cell cortex
## GO:0001558 regulation of cell growth GO:0001558 regulation of cell growth
## GO:0032559 adenyl ribonucleotide binding GO:0032559 adenyl ribonucleotide binding
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0006306 DNA methylation GO:0006306 DNA methylation
## GO:0021794 thalamus development GO:0021794 thalamus development
## GO:0035778 pronephric nephron tubule epithelial cell differentiation GO:0035778 pronephric nephron tubule epithelial cell differentiation
## GO:0071425 hematopoietic stem cell proliferation GO:0071425 hematopoietic stem cell proliferation
## GO:0000139 Golgi membrane GO:0000139 Golgi membrane
## GO:0007030 Golgi organization GO:0007030 Golgi organization
## GO:0043066 negative regulation of apoptotic process GO:0043066 negative regulation of apoptotic process
## GO:0004703 G protein-coupled receptor kinase activity GO:0004703 G protein-coupled receptor kinase activity
## GO:0045746 negative regulation of Notch signaling pathway GO:0045746 negative regulation of Notch signaling pathway
## GeneRatio
## GO:0001556 oocyte maturation 3/452
## GO:0030318 melanocyte differentiation 4/452
## GO:0005938 cell cortex 3/452
## GO:0001558 regulation of cell growth 2/452
## GO:0032559 adenyl ribonucleotide binding 2/452
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 14/452
## GO:0006306 DNA methylation 2/452
## GO:0021794 thalamus development 2/452
## GO:0035778 pronephric nephron tubule epithelial cell differentiation 2/452
## GO:0071425 hematopoietic stem cell proliferation 2/452
## GO:0000139 Golgi membrane 10/452
## GO:0007030 Golgi organization 2/452
## GO:0043066 negative regulation of apoptotic process 4/452
## GO:0004703 G protein-coupled receptor kinase activity 2/452
## GO:0045746 negative regulation of Notch signaling pathway 2/452
## BgRatio
## GO:0001556 oocyte maturation 8/18067
## GO:0030318 melanocyte differentiation 29/18067
## GO:0005938 cell cortex 15/18067
## GO:0001558 regulation of cell growth 5/18067
## GO:0032559 adenyl ribonucleotide binding 5/18067
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18067
## GO:0006306 DNA methylation 6/18067
## GO:0021794 thalamus development 6/18067
## GO:0035778 pronephric nephron tubule epithelial cell differentiation 6/18067
## GO:0071425 hematopoietic stem cell proliferation 7/18067
## GO:0000139 Golgi membrane 174/18067
## GO:0007030 Golgi organization 8/18067
## GO:0043066 negative regulation of apoptotic process 42/18067
## GO:0004703 G protein-coupled receptor kinase activity 10/18067
## GO:0045746 negative regulation of Notch signaling pathway 10/18067
## pvalue
## GO:0001556 oocyte maturation 0.0007931732
## GO:0030318 melanocyte differentiation 0.0055929837
## GO:0005938 cell cortex 0.0056566310
## GO:0001558 regulation of cell growth 0.0059401068
## GO:0032559 adenyl ribonucleotide binding 0.0059401068
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0060448734
## GO:0006306 DNA methylation 0.0087631139
## GO:0021794 thalamus development 0.0087631139
## GO:0035778 pronephric nephron tubule epithelial cell differentiation 0.0087631139
## GO:0071425 hematopoietic stem cell proliferation 0.0120663183
## GO:0000139 Golgi membrane 0.0123688203
## GO:0007030 Golgi organization 0.0158240333
## GO:0043066 negative regulation of apoptotic process 0.0204548415
## GO:0004703 G protein-coupled receptor kinase activity 0.0246051154
## GO:0045746 negative regulation of Notch signaling pathway 0.0246051154
## p.adjust
## GO:0001556 oocyte maturation 0.4703517
## GO:0030318 melanocyte differentiation 0.5710857
## GO:0005938 cell cortex 0.5710857
## GO:0001558 regulation of cell growth 0.5710857
## GO:0032559 adenyl ribonucleotide binding 0.5710857
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.5710857
## GO:0006306 DNA methylation 0.5710857
## GO:0021794 thalamus development 0.5710857
## GO:0035778 pronephric nephron tubule epithelial cell differentiation 0.5710857
## GO:0071425 hematopoietic stem cell proliferation 0.5710857
## GO:0000139 Golgi membrane 0.5710857
## GO:0007030 Golgi organization 0.5710857
## GO:0043066 negative regulation of apoptotic process 0.5710857
## GO:0004703 G protein-coupled receptor kinase activity 0.5710857
## GO:0045746 negative regulation of Notch signaling pathway 0.5710857
## qvalue
## GO:0001556 oocyte maturation 0.4700595
## GO:0030318 melanocyte differentiation 0.5707309
## GO:0005938 cell cortex 0.5707309
## GO:0001558 regulation of cell growth 0.5707309
## GO:0032559 adenyl ribonucleotide binding 0.5707309
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.5707309
## GO:0006306 DNA methylation 0.5707309
## GO:0021794 thalamus development 0.5707309
## GO:0035778 pronephric nephron tubule epithelial cell differentiation 0.5707309
## GO:0071425 hematopoietic stem cell proliferation 0.5707309
## GO:0000139 Golgi membrane 0.5707309
## GO:0007030 Golgi organization 0.5707309
## GO:0043066 negative regulation of apoptotic process 0.5707309
## GO:0004703 G protein-coupled receptor kinase activity 0.5707309
## GO:0045746 negative regulation of Notch signaling pathway 0.5707309
## geneID
## GO:0001556 oocyte maturation ENSPREG00000008256/ENSPREG00000010644/ENSPREG00000006009
## GO:0030318 melanocyte differentiation ENSPREG00000005012/ENSPREG00000016745/ENSPREG00000017205/ENSPREG00000002975
## GO:0005938 cell cortex ENSPREG00000006662/ENSPREG00000005482/ENSPREG00000022786
## GO:0001558 regulation of cell growth ENSPREG00000011250/ENSPREG00000015755
## GO:0032559 adenyl ribonucleotide binding ENSPREG00000004180/ENSPREG00000014979
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000002117/ENSPREG00000011367/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000012188/ENSPREG00000005993/ENSPREG00000013196/ENSPREG00000017440
## GO:0006306 DNA methylation ENSPREG00000014413/ENSPREG00000019660
## GO:0021794 thalamus development ENSPREG00000012325/ENSPREG00000006450
## GO:0035778 pronephric nephron tubule epithelial cell differentiation ENSPREG00000011115/ENSPREG00000017205
## GO:0071425 hematopoietic stem cell proliferation ENSPREG00000010644/ENSPREG00000007211
## GO:0000139 Golgi membrane ENSPREG00000005012/ENSPREG00000015921/ENSPREG00000001442/ENSPREG00000009222/ENSPREG00000021269/ENSPREG00000004517/ENSPREG00000019079/ENSPREG00000008413/ENSPREG00000001938/ENSPREG00000005797
## GO:0007030 Golgi organization ENSPREG00000005491/ENSPREG00000019079
## GO:0043066 negative regulation of apoptotic process ENSPREG00000000981/ENSPREG00000008375/ENSPREG00000004394/ENSPREG00000021398
## GO:0004703 G protein-coupled receptor kinase activity ENSPREG00000014142/ENSPREG00000000525
## GO:0045746 negative regulation of Notch signaling pathway ENSPREG00000011340/ENSPREG00000010644
## Count
## GO:0001556 oocyte maturation 3
## GO:0030318 melanocyte differentiation 4
## GO:0005938 cell cortex 3
## GO:0001558 regulation of cell growth 2
## GO:0032559 adenyl ribonucleotide binding 2
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 14
## GO:0006306 DNA methylation 2
## GO:0021794 thalamus development 2
## GO:0035778 pronephric nephron tubule epithelial cell differentiation 2
## GO:0071425 hematopoietic stem cell proliferation 2
## GO:0000139 Golgi membrane 10
## GO:0007030 Golgi organization 2
## GO:0043066 negative regulation of apoptotic process 4
## GO:0004703 G protein-coupled receptor kinase activity 2
## GO:0045746 negative regulation of Notch signaling pathway 2c_dn <- enricher(gene = CvL_dn, universe = CvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_dn,15)## ID
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GO:0030239 myofibril assembly GO:0030239 myofibril assembly
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0004383 guanylate cyclase activity GO:0004383 guanylate cyclase activity
## GO:0006182 cGMP biosynthetic process GO:0006182 cGMP biosynthetic process
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GO:0048663 neuron fate commitment GO:0048663 neuron fate commitment
## GO:0090136 epithelial cell-cell adhesion GO:0090136 epithelial cell-cell adhesion
## GO:0003143 embryonic heart tube morphogenesis GO:0003143 embryonic heart tube morphogenesis
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway GO:0003376 sphingosine-1-phosphate receptor signaling pathway
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0021536 diencephalon development GO:0021536 diencephalon development
## GO:0032956 regulation of actin cytoskeleton organization GO:0032956 regulation of actin cytoskeleton organization
## Description
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GO:0030239 myofibril assembly GO:0030239 myofibril assembly
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0004383 guanylate cyclase activity GO:0004383 guanylate cyclase activity
## GO:0006182 cGMP biosynthetic process GO:0006182 cGMP biosynthetic process
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GO:0048663 neuron fate commitment GO:0048663 neuron fate commitment
## GO:0090136 epithelial cell-cell adhesion GO:0090136 epithelial cell-cell adhesion
## GO:0003143 embryonic heart tube morphogenesis GO:0003143 embryonic heart tube morphogenesis
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway GO:0003376 sphingosine-1-phosphate receptor signaling pathway
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0021536 diencephalon development GO:0021536 diencephalon development
## GO:0032956 regulation of actin cytoskeleton organization GO:0032956 regulation of actin cytoskeleton organization
## GeneRatio
## GO:0007275 multicellular organism development 31/639
## GO:0046716 muscle cell cellular homeostasis 3/639
## GO:0030239 myofibril assembly 4/639
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 18/639
## GO:0004383 guanylate cyclase activity 3/639
## GO:0006182 cGMP biosynthetic process 3/639
## GO:0006384 transcription initiation from RNA polymerase III promoter 2/639
## GO:0048663 neuron fate commitment 2/639
## GO:0090136 epithelial cell-cell adhesion 2/639
## GO:0003143 embryonic heart tube morphogenesis 3/639
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 10/639
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway 2/639
## GO:0015245 fatty acid transmembrane transporter activity 2/639
## GO:0021536 diencephalon development 2/639
## GO:0032956 regulation of actin cytoskeleton organization 2/639
## BgRatio
## GO:0007275 multicellular organism development 480/18067
## GO:0046716 muscle cell cellular homeostasis 7/18067
## GO:0030239 myofibril assembly 18/18067
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18067
## GO:0004383 guanylate cyclase activity 13/18067
## GO:0006182 cGMP biosynthetic process 13/18067
## GO:0006384 transcription initiation from RNA polymerase III promoter 5/18067
## GO:0048663 neuron fate commitment 5/18067
## GO:0090136 epithelial cell-cell adhesion 5/18067
## GO:0003143 embryonic heart tube morphogenesis 14/18067
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 123/18067
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway 6/18067
## GO:0015245 fatty acid transmembrane transporter activity 6/18067
## GO:0021536 diencephalon development 6/18067
## GO:0032956 regulation of actin cytoskeleton organization 6/18067
## pvalue
## GO:0007275 multicellular organism development 0.0009733023
## GO:0046716 muscle cell cellular homeostasis 0.0013854140
## GO:0030239 myofibril assembly 0.0031926750
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0052974337
## GO:0004383 guanylate cyclase activity 0.0096598443
## GO:0006182 cGMP biosynthetic process 0.0096598443
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.0116325036
## GO:0048663 neuron fate commitment 0.0116325036
## GO:0090136 epithelial cell-cell adhesion 0.0116325036
## GO:0003143 embryonic heart tube morphogenesis 0.0119755916
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 0.0119791788
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway 0.0170422457
## GO:0015245 fatty acid transmembrane transporter activity 0.0170422457
## GO:0021536 diencephalon development 0.0170422457
## GO:0032956 regulation of actin cytoskeleton organization 0.0170422457
## p.adjust
## GO:0007275 multicellular organism development 0.4376789
## GO:0046716 muscle cell cellular homeostasis 0.4376789
## GO:0030239 myofibril assembly 0.4376789
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4376789
## GO:0004383 guanylate cyclase activity 0.4376789
## GO:0006182 cGMP biosynthetic process 0.4376789
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.4376789
## GO:0048663 neuron fate commitment 0.4376789
## GO:0090136 epithelial cell-cell adhesion 0.4376789
## GO:0003143 embryonic heart tube morphogenesis 0.4376789
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 0.4376789
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway 0.4376789
## GO:0015245 fatty acid transmembrane transporter activity 0.4376789
## GO:0021536 diencephalon development 0.4376789
## GO:0032956 regulation of actin cytoskeleton organization 0.4376789
## qvalue
## GO:0007275 multicellular organism development 0.4182331
## GO:0046716 muscle cell cellular homeostasis 0.4182331
## GO:0030239 myofibril assembly 0.4182331
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4182331
## GO:0004383 guanylate cyclase activity 0.4182331
## GO:0006182 cGMP biosynthetic process 0.4182331
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.4182331
## GO:0048663 neuron fate commitment 0.4182331
## GO:0090136 epithelial cell-cell adhesion 0.4182331
## GO:0003143 embryonic heart tube morphogenesis 0.4182331
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 0.4182331
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway 0.4182331
## GO:0015245 fatty acid transmembrane transporter activity 0.4182331
## GO:0021536 diencephalon development 0.4182331
## GO:0032956 regulation of actin cytoskeleton organization 0.4182331
## geneID
## GO:0007275 multicellular organism development ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000000133/ENSPREG00000023233/ENSPREG00000014079/ENSPREG00000013636/ENSPREG00000010790/ENSPREG00000008016/ENSPREG00000013353/ENSPREG00000021725/ENSPREG00000004106/ENSPREG00000004667/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000018360/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000002679/ENSPREG00000008534/ENSPREG00000014279/ENSPREG00000009944/ENSPREG00000011176/ENSPREG00000008300/ENSPREG00000019762/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000009870
## GO:0046716 muscle cell cellular homeostasis ENSPREG00000004187/ENSPREG00000020962/ENSPREG00000020904
## GO:0030239 myofibril assembly ENSPREG00000021266/ENSPREG00000014625/ENSPREG00000004106/ENSPREG00000007149
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000013636/ENSPREG00000013353/ENSPREG00000021725/ENSPREG00000001953/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000014279/ENSPREG00000017205/ENSPREG00000008300/ENSPREG00000009681
## GO:0004383 guanylate cyclase activity ENSPREG00000005428/ENSPREG00000020297/ENSPREG00000002322
## GO:0006182 cGMP biosynthetic process ENSPREG00000005428/ENSPREG00000020297/ENSPREG00000002322
## GO:0006384 transcription initiation from RNA polymerase III promoter ENSPREG00000021691/ENSPREG00000000142
## GO:0048663 neuron fate commitment ENSPREG00000004106/ENSPREG00000003743
## GO:0090136 epithelial cell-cell adhesion ENSPREG00000006377/ENSPREG00000019281
## GO:0003143 embryonic heart tube morphogenesis ENSPREG00000006261/ENSPREG00000004581/ENSPREG00000014440
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ENSPREG00000017815/ENSPREG00000019028/ENSPREG00000000942/ENSPREG00000020055/ENSPREG00000001576/ENSPREG00000019190/ENSPREG00000001096/ENSPREG00000022217/ENSPREG00000000083/ENSPREG00000010892
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway ENSPREG00000001253/ENSPREG00000013844
## GO:0015245 fatty acid transmembrane transporter activity ENSPREG00000000320/ENSPREG00000015498
## GO:0021536 diencephalon development ENSPREG00000004106/ENSPREG00000004531
## GO:0032956 regulation of actin cytoskeleton organization ENSPREG00000002964/ENSPREG00000014992
## Count
## GO:0007275 multicellular organism development 31
## GO:0046716 muscle cell cellular homeostasis 3
## GO:0030239 myofibril assembly 4
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 18
## GO:0004383 guanylate cyclase activity 3
## GO:0006182 cGMP biosynthetic process 3
## GO:0006384 transcription initiation from RNA polymerase III promoter 2
## GO:0048663 neuron fate commitment 2
## GO:0090136 epithelial cell-cell adhesion 2
## GO:0003143 embryonic heart tube morphogenesis 3
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 10
## GO:0003376 sphingosine-1-phosphate receptor signaling pathway 2
## GO:0015245 fatty acid transmembrane transporter activity 2
## GO:0021536 diencephalon development 2
## GO:0032956 regulation of actin cytoskeleton organization 2CvLunion <- union(CvL_up,CvL_dn)
c_union <- enricher(gene = CvLunion, universe = CvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_union,15)## ID
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0001558 regulation of cell growth GO:0001558 regulation of cell growth
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0004383 guanylate cyclase activity GO:0004383 guanylate cyclase activity
## GO:0006182 cGMP biosynthetic process GO:0006182 cGMP biosynthetic process
## GO:0106306 protein serine phosphatase activity GO:0106306 protein serine phosphatase activity
## GO:0106307 protein threonine phosphatase activity GO:0106307 protein threonine phosphatase activity
## GO:0001676 long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process
## GO:0004467 long-chain fatty acid-CoA ligase activity GO:0004467 long-chain fatty acid-CoA ligase activity
## GO:0015908 fatty acid transport GO:0015908 fatty acid transport
## GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## Description
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0001558 regulation of cell growth GO:0001558 regulation of cell growth
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0004383 guanylate cyclase activity GO:0004383 guanylate cyclase activity
## GO:0006182 cGMP biosynthetic process GO:0006182 cGMP biosynthetic process
## GO:0106306 protein serine phosphatase activity GO:0106306 protein serine phosphatase activity
## GO:0106307 protein threonine phosphatase activity GO:0106307 protein threonine phosphatase activity
## GO:0001676 long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process
## GO:0004467 long-chain fatty acid-CoA ligase activity GO:0004467 long-chain fatty acid-CoA ligase activity
## GO:0015908 fatty acid transport GO:0015908 fatty acid transport
## GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity
## GO:0046716 muscle cell cellular homeostasis GO:0046716 muscle cell cellular homeostasis
## GeneRatio
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 30/1075
## GO:0007275 multicellular organism development 47/1075
## GO:0001558 regulation of cell growth 3/1075
## GO:0006384 transcription initiation from RNA polymerase III promoter 3/1075
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 16/1075
## GO:0015245 fatty acid transmembrane transporter activity 3/1075
## GO:0004383 guanylate cyclase activity 4/1075
## GO:0006182 cGMP biosynthetic process 4/1075
## GO:0106306 protein serine phosphatase activity 10/1075
## GO:0106307 protein threonine phosphatase activity 10/1075
## GO:0001676 long-chain fatty acid metabolic process 3/1075
## GO:0004467 long-chain fatty acid-CoA ligase activity 3/1075
## GO:0015908 fatty acid transport 3/1075
## GO:0031957 very long-chain fatty acid-CoA ligase activity 3/1075
## GO:0046716 muscle cell cellular homeostasis 3/1075
## BgRatio
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18067
## GO:0007275 multicellular organism development 480/18067
## GO:0001558 regulation of cell growth 5/18067
## GO:0006384 transcription initiation from RNA polymerase III promoter 5/18067
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 123/18067
## GO:0015245 fatty acid transmembrane transporter activity 6/18067
## GO:0004383 guanylate cyclase activity 13/18067
## GO:0006182 cGMP biosynthetic process 13/18067
## GO:0106306 protein serine phosphatase activity 67/18067
## GO:0106307 protein threonine phosphatase activity 67/18067
## GO:0001676 long-chain fatty acid metabolic process 7/18067
## GO:0004467 long-chain fatty acid-CoA ligase activity 7/18067
## GO:0015908 fatty acid transport 7/18067
## GO:0031957 very long-chain fatty acid-CoA ligase activity 7/18067
## GO:0046716 muscle cell cellular homeostasis 7/18067
## pvalue
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0003955448
## GO:0007275 multicellular organism development 0.0005465437
## GO:0001558 regulation of cell growth 0.0019184131
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.0019184131
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 0.0025799120
## GO:0015245 fatty acid transmembrane transporter activity 0.0036671063
## GO:0004383 guanylate cyclase activity 0.0057781554
## GO:0006182 cGMP biosynthetic process 0.0057781554
## GO:0106306 protein serine phosphatase activity 0.0059975968
## GO:0106307 protein threonine phosphatase activity 0.0059975968
## GO:0001676 long-chain fatty acid metabolic process 0.0061344571
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.0061344571
## GO:0015908 fatty acid transport 0.0061344571
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.0061344571
## GO:0046716 muscle cell cellular homeostasis 0.0061344571
## p.adjust
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.2683530
## GO:0007275 multicellular organism development 0.2683530
## GO:0001558 regulation of cell growth 0.4016025
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.4016025
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 0.4016025
## GO:0015245 fatty acid transmembrane transporter activity 0.4016025
## GO:0004383 guanylate cyclase activity 0.4016025
## GO:0006182 cGMP biosynthetic process 0.4016025
## GO:0106306 protein serine phosphatase activity 0.4016025
## GO:0106307 protein threonine phosphatase activity 0.4016025
## GO:0001676 long-chain fatty acid metabolic process 0.4016025
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.4016025
## GO:0015908 fatty acid transport 0.4016025
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.4016025
## GO:0046716 muscle cell cellular homeostasis 0.4016025
## qvalue
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.2640669
## GO:0007275 multicellular organism development 0.2640669
## GO:0001558 regulation of cell growth 0.3951882
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.3951882
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 0.3951882
## GO:0015245 fatty acid transmembrane transporter activity 0.3951882
## GO:0004383 guanylate cyclase activity 0.3951882
## GO:0006182 cGMP biosynthetic process 0.3951882
## GO:0106306 protein serine phosphatase activity 0.3951882
## GO:0106307 protein threonine phosphatase activity 0.3951882
## GO:0001676 long-chain fatty acid metabolic process 0.3951882
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.3951882
## GO:0015908 fatty acid transport 0.3951882
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.3951882
## GO:0046716 muscle cell cellular homeostasis 0.3951882
## geneID
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000002117/ENSPREG00000011367/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000017205/ENSPREG00000012188/ENSPREG00000005993/ENSPREG00000013196/ENSPREG00000017440/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000013636/ENSPREG00000013353/ENSPREG00000001953/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000014279/ENSPREG00000008300/ENSPREG00000009681
## GO:0007275 multicellular organism development ENSPREG00000021725/ENSPREG00000004660/ENSPREG00000007669/ENSPREG00000022340/ENSPREG00000012325/ENSPREG00000011115/ENSPREG00000012168/ENSPREG00000007342/ENSPREG00000002117/ENSPREG00000011367/ENSPREG00000012582/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000005482/ENSPREG00000018360/ENSPREG00000016605/ENSPREG00000013196/ENSPREG00000017440/ENSPREG00000020332/ENSPREG00000000557/ENSPREG00000020178/ENSPREG00000000563/ENSPREG00000021717/ENSPREG00000021021/ENSPREG00000000133/ENSPREG00000023233/ENSPREG00000014079/ENSPREG00000013636/ENSPREG00000010790/ENSPREG00000008016/ENSPREG00000013353/ENSPREG00000004106/ENSPREG00000004667/ENSPREG00000005380/ENSPREG00000011620/ENSPREG00000004436/ENSPREG00000011713/ENSPREG00000002679/ENSPREG00000008534/ENSPREG00000014279/ENSPREG00000009944/ENSPREG00000011176/ENSPREG00000008300/ENSPREG00000019762/ENSPREG00000009681/ENSPREG00000013209/ENSPREG00000009870
## GO:0001558 regulation of cell growth ENSPREG00000011250/ENSPREG00000015755/ENSPREG00000018001
## GO:0006384 transcription initiation from RNA polymerase III promoter ENSPREG00000021756/ENSPREG00000021691/ENSPREG00000000142
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ENSPREG00000019147/ENSPREG00000001576/ENSPREG00000000982/ENSPREG00000001032/ENSPREG00000019006/ENSPREG00000018962/ENSPREG00000001444/ENSPREG00000017815/ENSPREG00000019028/ENSPREG00000000942/ENSPREG00000020055/ENSPREG00000019190/ENSPREG00000001096/ENSPREG00000022217/ENSPREG00000000083/ENSPREG00000010892
## GO:0015245 fatty acid transmembrane transporter activity ENSPREG00000015513/ENSPREG00000000320/ENSPREG00000015498
## GO:0004383 guanylate cyclase activity ENSPREG00000020922/ENSPREG00000005428/ENSPREG00000020297/ENSPREG00000002322
## GO:0006182 cGMP biosynthetic process ENSPREG00000020922/ENSPREG00000005428/ENSPREG00000020297/ENSPREG00000002322
## GO:0106306 protein serine phosphatase activity ENSPREG00000012357/ENSPREG00000014983/ENSPREG00000012040/ENSPREG00000021947/ENSPREG00000021264/ENSPREG00000021732/ENSPREG00000009872/ENSPREG00000005151/ENSPREG00000006482/ENSPREG00000021038
## GO:0106307 protein threonine phosphatase activity ENSPREG00000012357/ENSPREG00000014983/ENSPREG00000012040/ENSPREG00000021947/ENSPREG00000021264/ENSPREG00000021732/ENSPREG00000009872/ENSPREG00000005151/ENSPREG00000006482/ENSPREG00000021038
## GO:0001676 long-chain fatty acid metabolic process ENSPREG00000015513/ENSPREG00000000320/ENSPREG00000015498
## GO:0004467 long-chain fatty acid-CoA ligase activity ENSPREG00000015513/ENSPREG00000000320/ENSPREG00000015498
## GO:0015908 fatty acid transport ENSPREG00000015513/ENSPREG00000000320/ENSPREG00000015498
## GO:0031957 very long-chain fatty acid-CoA ligase activity ENSPREG00000015513/ENSPREG00000000320/ENSPREG00000015498
## GO:0046716 muscle cell cellular homeostasis ENSPREG00000004187/ENSPREG00000020962/ENSPREG00000020904
## Count
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 30
## GO:0007275 multicellular organism development 47
## GO:0001558 regulation of cell growth 3
## GO:0006384 transcription initiation from RNA polymerase III promoter 3
## GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 16
## GO:0015245 fatty acid transmembrane transporter activity 3
## GO:0004383 guanylate cyclase activity 4
## GO:0006182 cGMP biosynthetic process 4
## GO:0106306 protein serine phosphatase activity 10
## GO:0106307 protein threonine phosphatase activity 10
## GO:0001676 long-chain fatty acid metabolic process 3
## GO:0004467 long-chain fatty acid-CoA ligase activity 3
## GO:0015908 fatty acid transport 3
## GO:0031957 very long-chain fatty acid-CoA ligase activity 3
## GO:0046716 muscle cell cellular homeostasis 3library(reshape2)
GvL_up <- subset(GvL,meth.diff>0&qvalue<0.05)
GvL_up <- unique(GvL_up$gene_id)
str(GvL_up)## chr [1:4176] "ENSPREG00000002699" "ENSPREG00000004582" ...GvL_dn <- subset(GvL,meth.diff<0&qvalue<0.05)
GvL_dn <- unique(GvL_dn$gene_id)
str(CvL_dn)## chr [1:763] "ENSPREG00000014846" "ENSPREG00000010182" "ENSPREG00000012722" ...GvL_bg <- unique(GvL$gene_id)
str(GvL_bg)## chr [1:21615] "ENSPREG00000021468" "ENSPREG00000021490" ...c_up <- enricher(gene = GvL_up, universe = GvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_up,15)## ID
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0007154 cell communication GO:0007154 cell communication
## GO:0032264 IMP salvage GO:0032264 IMP salvage
## GO:0003690 double-stranded DNA binding GO:0003690 double-stranded DNA binding
## GO:0006166 purine ribonucleoside salvage GO:0006166 purine ribonucleoside salvage
## GO:0032012 regulation of ARF protein signal transduction GO:0032012 regulation of ARF protein signal transduction
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
## GO:0072015 glomerular visceral epithelial cell development GO:0072015 glomerular visceral epithelial cell development
## GO:0005244 voltage-gated ion channel activity GO:0005244 voltage-gated ion channel activity
## GO:0034765 regulation of ion transmembrane transport GO:0034765 regulation of ion transmembrane transport
## GO:0003677 DNA binding GO:0003677 DNA binding
## Description
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0007154 cell communication GO:0007154 cell communication
## GO:0032264 IMP salvage GO:0032264 IMP salvage
## GO:0003690 double-stranded DNA binding GO:0003690 double-stranded DNA binding
## GO:0006166 purine ribonucleoside salvage GO:0006166 purine ribonucleoside salvage
## GO:0032012 regulation of ARF protein signal transduction GO:0032012 regulation of ARF protein signal transduction
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
## GO:0072015 glomerular visceral epithelial cell development GO:0072015 glomerular visceral epithelial cell development
## GO:0005244 voltage-gated ion channel activity GO:0005244 voltage-gated ion channel activity
## GO:0034765 regulation of ion transmembrane transport GO:0034765 regulation of ion transmembrane transport
## GO:0003677 DNA binding GO:0003677 DNA binding
## GeneRatio
## GO:0007275 multicellular organism development 134/3497
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 73/3497
## GO:0006355 regulation of transcription, DNA-templated 207/3497
## GO:0005515 protein binding 720/3497
## GO:0005634 nucleus 457/3497
## GO:0007154 cell communication 21/3497
## GO:0032264 IMP salvage 6/3497
## GO:0003690 double-stranded DNA binding 8/3497
## GO:0006166 purine ribonucleoside salvage 5/3497
## GO:0032012 regulation of ARF protein signal transduction 10/3497
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6/3497
## GO:0072015 glomerular visceral epithelial cell development 8/3497
## GO:0005244 voltage-gated ion channel activity 36/3497
## GO:0034765 regulation of ion transmembrane transport 36/3497
## GO:0003677 DNA binding 250/3497
## BgRatio
## GO:0007275 multicellular organism development 480/18091
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18091
## GO:0006355 regulation of transcription, DNA-templated 875/18091
## GO:0005515 protein binding 3397/18091
## GO:0005634 nucleus 2108/18091
## GO:0007154 cell communication 59/18091
## GO:0032264 IMP salvage 9/18091
## GO:0003690 double-stranded DNA binding 15/18091
## GO:0006166 purine ribonucleoside salvage 7/18091
## GO:0032012 regulation of ARF protein signal transduction 22/18091
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 10/18091
## GO:0072015 glomerular visceral epithelial cell development 16/18091
## GO:0005244 voltage-gated ion channel activity 127/18091
## GO:0034765 regulation of ion transmembrane transport 127/18091
## GO:0003677 DNA binding 1131/18091
## pvalue
## GO:0007275 multicellular organism development 2.487405e-06
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 3.741238e-04
## GO:0006355 regulation of transcription, DNA-templated 6.693009e-04
## GO:0005515 protein binding 1.321471e-03
## GO:0005634 nucleus 2.219565e-03
## GO:0007154 cell communication 2.476662e-03
## GO:0032264 IMP salvage 2.544410e-03
## GO:0003690 double-stranded DNA binding 3.378246e-03
## GO:0006166 purine ribonucleoside salvage 3.985327e-03
## GO:0032012 regulation of ARF protein signal transduction 4.736909e-03
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 5.321910e-03
## GO:0072015 glomerular visceral epithelial cell development 5.620452e-03
## GO:0005244 voltage-gated ion channel activity 8.775471e-03
## GO:0034765 regulation of ion transmembrane transport 8.775471e-03
## GO:0003677 DNA binding 8.883887e-03
## p.adjust
## GO:0007275 multicellular organism development 0.003912688
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.294248386
## GO:0006355 regulation of transcription, DNA-templated 0.350936750
## GO:0005515 protein binding 0.519668407
## GO:0005634 nucleus 0.571765313
## GO:0007154 cell communication 0.571765313
## GO:0032264 IMP salvage 0.571765313
## GO:0003690 double-stranded DNA binding 0.664247531
## GO:0006166 purine ribonucleoside salvage 0.696546684
## GO:0032012 regulation of ARF protein signal transduction 0.736747529
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 0.736747529
## GO:0072015 glomerular visceral epithelial cell development 0.736747529
## GO:0005244 voltage-gated ion channel activity 0.780951931
## GO:0034765 regulation of ion transmembrane transport 0.780951931
## GO:0003677 DNA binding 0.780951931
## qvalue
## GO:0007275 multicellular organism development 0.003912688
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.294248386
## GO:0006355 regulation of transcription, DNA-templated 0.350936750
## GO:0005515 protein binding 0.519668407
## GO:0005634 nucleus 0.571765313
## GO:0007154 cell communication 0.571765313
## GO:0032264 IMP salvage 0.571765313
## GO:0003690 double-stranded DNA binding 0.664247531
## GO:0006166 purine ribonucleoside salvage 0.696546684
## GO:0032012 regulation of ARF protein signal transduction 0.736747529
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 0.736747529
## GO:0072015 glomerular visceral epithelial cell development 0.736747529
## GO:0005244 voltage-gated ion channel activity 0.780951931
## GO:0034765 regulation of ion transmembrane transport 0.780951931
## GO:0003677 DNA binding 0.780951931
## geneID
## GO:0007275 multicellular organism development ENSPREG00000020203/ENSPREG00000021322/ENSPREG00000011367/ENSPREG00000001369/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000006315/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000000612/ENSPREG00000002795/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000021144/ENSPREG00000009481/ENSPREG00000018023/ENSPREG00000019494/ENSPREG00000008962/ENSPREG00000016797/ENSPREG00000009349/ENSPREG00000010250/ENSPREG00000011561/ENSPREG00000013766/ENSPREG00000012325/ENSPREG00000015810/ENSPREG00000018652/ENSPREG00000012105/ENSPREG00000017347/ENSPREG00000007498/ENSPREG00000021106/ENSPREG00000006945/ENSPREG00000007342/ENSPREG00000011441/ENSPREG00000013058/ENSPREG00000006544/ENSPREG00000008377/ENSPREG00000005482/ENSPREG00000001072/ENSPREG00000021474/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000017582/ENSPREG00000019060/ENSPREG00000016476/ENSPREG00000016256/ENSPREG00000020385/ENSPREG00000023206/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000000290/ENSPREG00000019816/ENSPREG00000012697/ENSPREG00000022340/ENSPREG00000007061/ENSPREG00000015499/ENSPREG00000006276/ENSPREG00000000081/ENSPREG00000013353/ENSPREG00000012157/ENSPREG00000013812/ENSPREG00000011115/ENSPREG00000020206/ENSPREG00000009183/ENSPREG00000006008/ENSPREG00000018739/ENSPREG00000004544/ENSPREG00000019531/ENSPREG00000019774/ENSPREG00000005380/ENSPREG00000017388/ENSPREG00000006758/ENSPREG00000018360/ENSPREG00000018299/ENSPREG00000014903/ENSPREG00000009731/ENSPREG00000014120/ENSPREG00000020252/ENSPREG00000015465/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000009131/ENSPREG00000004067/ENSPREG00000006998/ENSPREG00000012420/ENSPREG00000015409/ENSPREG00000018757/ENSPREG00000008022/ENSPREG00000016630/ENSPREG00000008761/ENSPREG00000006631/ENSPREG00000015189/ENSPREG00000014784/ENSPREG00000009250/ENSPREG00000017666/ENSPREG00000002598/ENSPREG00000001334/ENSPREG00000010793/ENSPREG00000010872/ENSPREG00000007418/ENSPREG00000018822/ENSPREG00000016622/ENSPREG00000005412/ENSPREG00000018009/ENSPREG00000017718/ENSPREG00000013196/ENSPREG00000006981/ENSPREG00000008184/ENSPREG00000009155/ENSPREG00000006819/ENSPREG00000006806/ENSPREG00000015450/ENSPREG00000018004/ENSPREG00000021337/ENSPREG00000014891/ENSPREG00000002673/ENSPREG00000019962/ENSPREG00000000133/ENSPREG00000001918/ENSPREG00000011131/ENSPREG00000019762/ENSPREG00000009681/ENSPREG00000009942/ENSPREG00000006796/ENSPREG00000006388/ENSPREG00000002053/ENSPREG00000012707/ENSPREG00000019085
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000006315/ENSPREG00000013067/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000002795/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000018023/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000012325/ENSPREG00000015810/ENSPREG00000012105/ENSPREG00000007498/ENSPREG00000006945/ENSPREG00000011441/ENSPREG00000013058/ENSPREG00000005993/ENSPREG00000008377/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000021630/ENSPREG00000016256/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000000290/ENSPREG00000022340/ENSPREG00000006276/ENSPREG00000013353/ENSPREG00000013812/ENSPREG00000011115/ENSPREG00000019531/ENSPREG00000005380/ENSPREG00000006758/ENSPREG00000015465/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000006998/ENSPREG00000013765/ENSPREG00000012420/ENSPREG00000021486/ENSPREG00000006631/ENSPREG00000015189/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000017666/ENSPREG00000001334/ENSPREG00000015043/ENSPREG00000021574/ENSPREG00000013196/ENSPREG00000009155/ENSPREG00000006819/ENSPREG00000013623/ENSPREG00000000949/ENSPREG00000006806/ENSPREG00000015450/ENSPREG00000021337/ENSPREG00000019962/ENSPREG00000011131/ENSPREG00000009681/ENSPREG00000006796/ENSPREG00000006388
## GO:0006355 regulation of transcription, DNA-templated ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000003428/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000005246/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000018881/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000014960/ENSPREG00000002795/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000000313/ENSPREG00000013048/ENSPREG00000010086/ENSPREG00000018023/ENSPREG00000021553/ENSPREG00000022723/ENSPREG00000014608/ENSPREG00000011064/ENSPREG00000014097/ENSPREG00000022546/ENSPREG00000003440/ENSPREG00000004029/ENSPREG00000005028/ENSPREG00000016797/ENSPREG00000010250/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000013766/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000021316/ENSPREG00000012325/ENSPREG00000017021/ENSPREG00000015810/ENSPREG00000013403/ENSPREG00000011212/ENSPREG00000012105/ENSPREG00000007498/ENSPREG00000006945/ENSPREG00000016676/ENSPREG00000007342/ENSPREG00000009326/ENSPREG00000011441/ENSPREG00000019519/ENSPREG00000013058/ENSPREG00000006544/ENSPREG00000008377/ENSPREG00000007906/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000017582/ENSPREG00000003918/ENSPREG00000015905/ENSPREG00000017247/ENSPREG00000011942/ENSPREG00000010162/ENSPREG00000018925/ENSPREG00000019566/ENSPREG00000021630/ENSPREG00000001543/ENSPREG00000016256/ENSPREG00000022772/ENSPREG00000023206/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000023148/ENSPREG00000011231/ENSPREG00000000290/ENSPREG00000017649/ENSPREG00000015654/ENSPREG00000016146/ENSPREG00000003063/ENSPREG00000015395/ENSPREG00000018974/ENSPREG00000007429/ENSPREG00000022340/ENSPREG00000011269/ENSPREG00000007997/ENSPREG00000015499/ENSPREG00000017887/ENSPREG00000006276/ENSPREG00000002822/ENSPREG00000013353/ENSPREG00000021982/ENSPREG00000022365/ENSPREG00000010841/ENSPREG00000009008/ENSPREG00000023244/ENSPREG00000017352/ENSPREG00000013812/ENSPREG00000011115/ENSPREG00000022066/ENSPREG00000011877/ENSPREG00000021136/ENSPREG00000019531/ENSPREG00000020804/ENSPREG00000004768/ENSPREG00000004398/ENSPREG00000005380/ENSPREG00000012965/ENSPREG00000002259/ENSPREG00000006758/ENSPREG00000009056/ENSPREG00000009731/ENSPREG00000001226/ENSPREG00000014803/ENSPREG00000015465/ENSPREG00000021052/ENSPREG00000018746/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000009131/ENSPREG00000011496/ENSPREG00000008402/ENSPREG00000011930/ENSPREG00000022910/ENSPREG00000002926/ENSPREG00000008997/ENSPREG00000006998/ENSPREG00000021362/ENSPREG00000012420/ENSPREG00000008972/ENSPREG00000010182/ENSPREG00000019537/ENSPREG00000020466/ENSPREG00000015409/ENSPREG00000000847/ENSPREG00000008918/ENSPREG00000022501/ENSPREG00000008761/ENSPREG00000018558/ENSPREG00000000792/ENSPREG00000006455/ENSPREG00000011189/ENSPREG00000006631/ENSPREG00000007784/ENSPREG00000015189/ENSPREG00000017365/ENSPREG00000007884/ENSPREG00000014784/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000017666/ENSPREG00000000434/ENSPREG00000001334/ENSPREG00000015981/ENSPREG00000011732/ENSPREG00000021574/ENSPREG00000014207/ENSPREG00000013196/ENSPREG00000020992/ENSPREG00000010818/ENSPREG00000003680/ENSPREG00000016863/ENSPREG00000022630/ENSPREG00000005038/ENSPREG00000009155/ENSPREG00000005008/ENSPREG00000006819/ENSPREG00000013848/ENSPREG00000013623/ENSPREG00000022317/ENSPREG00000009052/ENSPREG00000010581/ENSPREG00000013800/ENSPREG00000006806/ENSPREG00000011546/ENSPREG00000018249/ENSPREG00000015450/ENSPREG00000018193/ENSPREG00000009850/ENSPREG00000022410/ENSPREG00000021337/ENSPREG00000019455/ENSPREG00000019962/ENSPREG00000010102/ENSPREG00000011131/ENSPREG00000019762/ENSPREG00000011387/ENSPREG00000005818/ENSPREG00000009681/ENSPREG00000018056/ENSPREG00000011677/ENSPREG00000006796/ENSPREG00000006388/ENSPREG00000002487/ENSPREG00000018453/ENSPREG00000011959/ENSPREG00000004232
## GO:0005515 protein binding ENSPREG00000004594/ENSPREG00000011953/ENSPREG00000012251/ENSPREG00000005998/ENSPREG00000012853/ENSPREG00000018477/ENSPREG00000019319/ENSPREG00000021322/ENSPREG00000001335/ENSPREG00000015471/ENSPREG00000017867/ENSPREG00000005048/ENSPREG00000002585/ENSPREG00000012822/ENSPREG00000006498/ENSPREG00000006662/ENSPREG00000009060/ENSPREG00000022512/ENSPREG00000013014/ENSPREG00000006443/ENSPREG00000014506/ENSPREG00000017977/ENSPREG00000012897/ENSPREG00000020661/ENSPREG00000021152/ENSPREG00000001239/ENSPREG00000007778/ENSPREG00000017204/ENSPREG00000002248/ENSPREG00000019970/ENSPREG00000020137/ENSPREG00000001142/ENSPREG00000009748/ENSPREG00000008576/ENSPREG00000016967/ENSPREG00000009420/ENSPREG00000023130/ENSPREG00000021756/ENSPREG00000012860/ENSPREG00000019090/ENSPREG00000004636/ENSPREG00000005315/ENSPREG00000001734/ENSPREG00000018881/ENSPREG00000002194/ENSPREG00000013460/ENSPREG00000017713/ENSPREG00000004055/ENSPREG00000003556/ENSPREG00000014973/ENSPREG00000011222/ENSPREG00000018815/ENSPREG00000021689/ENSPREG00000013339/ENSPREG00000010675/ENSPREG00000015324/ENSPREG00000006112/ENSPREG00000000629/ENSPREG00000019123/ENSPREG00000003610/ENSPREG00000012466/ENSPREG00000020310/ENSPREG00000000313/ENSPREG00000002366/ENSPREG00000013162/ENSPREG00000018168/ENSPREG00000009555/ENSPREG00000010398/ENSPREG00000012620/ENSPREG00000022961/ENSPREG00000018867/ENSPREG00000004777/ENSPREG00000022326/ENSPREG00000022339/ENSPREG00000009493/ENSPREG00000022133/ENSPREG00000019390/ENSPREG00000022366/ENSPREG00000019952/ENSPREG00000021215/ENSPREG00000006634/ENSPREG00000007157/ENSPREG00000016525/ENSPREG00000011896/ENSPREG00000009469/ENSPREG00000003508/ENSPREG00000003290/ENSPREG00000011758/ENSPREG00000000685/ENSPREG00000010125/ENSPREG00000006987/ENSPREG00000021622/ENSPREG00000002476/ENSPREG00000014608/ENSPREG00000001983/ENSPREG00000011064/ENSPREG00000001980/ENSPREG00000008778/ENSPREG00000000341/ENSPREG00000015155/ENSPREG00000020009/ENSPREG00000010341/ENSPREG00000017454/ENSPREG00000012413/ENSPREG00000014822/ENSPREG00000004263/ENSPREG00000008123/ENSPREG00000021865/ENSPREG00000020140/ENSPREG00000022616/ENSPREG00000004029/ENSPREG00000005051/ENSPREG00000019340/ENSPREG00000009666/ENSPREG00000004300/ENSPREG00000015991/ENSPREG00000011159/ENSPREG00000000588/ENSPREG00000010064/ENSPREG00000017657/ENSPREG00000006440/ENSPREG00000004736/ENSPREG00000022808/ENSPREG00000005875/ENSPREG00000000164/ENSPREG00000015245/ENSPREG00000011352/ENSPREG00000007731/ENSPREG00000001779/ENSPREG00000000954/ENSPREG00000014507/ENSPREG00000022767/ENSPREG00000007331/ENSPREG00000021401/ENSPREG00000006028/ENSPREG00000011331/ENSPREG00000015478/ENSPREG00000004312/ENSPREG00000022344/ENSPREG00000009801/ENSPREG00000000217/ENSPREG00000022594/ENSPREG00000018440/ENSPREG00000011036/ENSPREG00000013046/ENSPREG00000018664/ENSPREG00000001224/ENSPREG00000005794/ENSPREG00000003283/ENSPREG00000020701/ENSPREG00000003868/ENSPREG00000016489/ENSPREG00000007238/ENSPREG00000003115/ENSPREG00000013249/ENSPREG00000016307/ENSPREG00000007748/ENSPREG00000004285/ENSPREG00000018652/ENSPREG00000003639/ENSPREG00000006611/ENSPREG00000005611/ENSPREG00000004333/ENSPREG00000015114/ENSPREG00000006436/ENSPREG00000022747/ENSPREG00000020067/ENSPREG00000006682/ENSPREG00000001951/ENSPREG00000015233/ENSPREG00000005618/ENSPREG00000021106/ENSPREG00000021765/ENSPREG00000000779/ENSPREG00000010589/ENSPREG00000020380/ENSPREG00000020450/ENSPREG00000011954/ENSPREG00000012408/ENSPREG00000019635/ENSPREG00000017741/ENSPREG00000016502/ENSPREG00000013733/ENSPREG00000006914/ENSPREG00000021603/ENSPREG00000006544/ENSPREG00000002124/ENSPREG00000006678/ENSPREG00000008052/ENSPREG00000000950/ENSPREG00000001638/ENSPREG00000017444/ENSPREG00000021455/ENSPREG00000001482/ENSPREG00000010540/ENSPREG00000005421/ENSPREG00000013763/ENSPREG00000008274/ENSPREG00000013942/ENSPREG00000013074/ENSPREG00000022805/ENSPREG00000017574/ENSPREG00000011082/ENSPREG00000011132/ENSPREG00000018853/ENSPREG00000019044/ENSPREG00000017582/ENSPREG00000018413/ENSPREG00000022346/ENSPREG00000003053/ENSPREG00000003918/ENSPREG00000003789/ENSPREG00000010697/ENSPREG00000015905/ENSPREG00000017881/ENSPREG00000000593/ENSPREG00000017247/ENSPREG00000020214/ENSPREG00000002294/ENSPREG00000019665/ENSPREG00000010162/ENSPREG00000018599/ENSPREG00000018925/ENSPREG00000019676/ENSPREG00000007113/ENSPREG00000018426/ENSPREG00000010861/ENSPREG00000006420/ENSPREG00000020747/ENSPREG00000012900/ENSPREG00000002626/ENSPREG00000015822/ENSPREG00000020634/ENSPREG00000018410/ENSPREG00000005336/ENSPREG00000003791/ENSPREG00000007359/ENSPREG00000011865/ENSPREG00000022717/ENSPREG00000019594/ENSPREG00000005420/ENSPREG00000021324/ENSPREG00000005590/ENSPREG00000019957/ENSPREG00000002219/ENSPREG00000020729/ENSPREG00000019070/ENSPREG00000022577/ENSPREG00000021702/ENSPREG00000022909/ENSPREG00000019228/ENSPREG00000015809/ENSPREG00000016890/ENSPREG00000009910/ENSPREG00000021727/ENSPREG00000016174/ENSPREG00000002972/ENSPREG00000020325/ENSPREG00000003558/ENSPREG00000021213/ENSPREG00000019816/ENSPREG00000007115/ENSPREG00000004228/ENSPREG00000000181/ENSPREG00000006035/ENSPREG00000011389/ENSPREG00000020136/ENSPREG00000016562/ENSPREG00000009434/ENSPREG00000023195/ENSPREG00000016861/ENSPREG00000012846/ENSPREG00000022874/ENSPREG00000005952/ENSPREG00000021025/ENSPREG00000004576/ENSPREG00000000414/ENSPREG00000014698/ENSPREG00000020745/ENSPREG00000016294/ENSPREG00000019002/ENSPREG00000006655/ENSPREG00000006393/ENSPREG00000018452/ENSPREG00000021435/ENSPREG00000000059/ENSPREG00000019374/ENSPREG00000022590/ENSPREG00000017366/ENSPREG00000001790/ENSPREG00000015143/ENSPREG00000014141/ENSPREG00000006668/ENSPREG00000019417/ENSPREG00000020451/ENSPREG00000012167/ENSPREG00000011946/ENSPREG00000008293/ENSPREG00000021425/ENSPREG00000022224/ENSPREG00000017617/ENSPREG00000009091/ENSPREG00000000958/ENSPREG00000016663/ENSPREG00000013492/ENSPREG00000018266/ENSPREG00000005931/ENSPREG00000014503/ENSPREG00000018422/ENSPREG00000021256/ENSPREG00000011786/ENSPREG00000005086/ENSPREG00000013858/ENSPREG00000019186/ENSPREG00000018926/ENSPREG00000016295/ENSPREG00000017887/ENSPREG00000006438/ENSPREG00000013242/ENSPREG00000020456/ENSPREG00000000081/ENSPREG00000022222/ENSPREG00000009984/ENSPREG00000003979/ENSPREG00000023083/ENSPREG00000003561/ENSPREG00000006194/ENSPREG00000015626/ENSPREG00000022278/ENSPREG00000018891/ENSPREG00000000544/ENSPREG00000003003/ENSPREG00000022819/ENSPREG00000022570/ENSPREG00000004565/ENSPREG00000016136/ENSPREG00000011134/ENSPREG00000017179/ENSPREG00000005148/ENSPREG00000003987/ENSPREG00000017914/ENSPREG00000007601/ENSPREG00000011431/ENSPREG00000023244/ENSPREG00000019613/ENSPREG00000010712/ENSPREG00000016004/ENSPREG00000017448/ENSPREG00000010200/ENSPREG00000006669/ENSPREG00000012552/ENSPREG00000013262/ENSPREG00000004343/ENSPREG00000020971/ENSPREG00000015068/ENSPREG00000000817/ENSPREG00000020144/ENSPREG00000002199/ENSPREG00000009177/ENSPREG00000020784/ENSPREG00000005065/ENSPREG00000007903/ENSPREG00000017709/ENSPREG00000005185/ENSPREG00000018400/ENSPREG00000001725/ENSPREG00000022223/ENSPREG00000013653/ENSPREG00000009276/ENSPREG00000011322/ENSPREG00000011877/ENSPREG00000003965/ENSPREG00000004054/ENSPREG00000018739/ENSPREG00000002348/ENSPREG00000022836/ENSPREG00000014283/ENSPREG00000010225/ENSPREG00000016160/ENSPREG00000012500/ENSPREG00000008282/ENSPREG00000022372/ENSPREG00000016455/ENSPREG00000015764/ENSPREG00000005603/ENSPREG00000006253/ENSPREG00000018283/ENSPREG00000016542/ENSPREG00000012394/ENSPREG00000012534/ENSPREG00000023048/ENSPREG00000008155/ENSPREG00000020238/ENSPREG00000009226/ENSPREG00000021481/ENSPREG00000018360/ENSPREG00000007226/ENSPREG00000001594/ENSPREG00000020189/ENSPREG00000019101/ENSPREG00000018284/ENSPREG00000007523/ENSPREG00000014903/ENSPREG00000019086/ENSPREG00000015772/ENSPREG00000021020/ENSPREG00000010337/ENSPREG00000008825/ENSPREG00000012783/ENSPREG00000022843/ENSPREG00000016656/ENSPREG00000021224/ENSPREG00000005614/ENSPREG00000020252/ENSPREG00000002370/ENSPREG00000007974/ENSPREG00000002311/ENSPREG00000010930/ENSPREG00000008672/ENSPREG00000020167/ENSPREG00000022076/ENSPREG00000002771/ENSPREG00000002457/ENSPREG00000014625/ENSPREG00000009816/ENSPREG00000007713/ENSPREG00000014570/ENSPREG00000015652/ENSPREG00000002292/ENSPREG00000017550/ENSPREG00000001752/ENSPREG00000020768/ENSPREG00000006738/ENSPREG00000001563/ENSPREG00000019089/ENSPREG00000013300/ENSPREG00000011930/ENSPREG00000007324/ENSPREG00000014793/ENSPREG00000009793/ENSPREG00000018286/ENSPREG00000004067/ENSPREG00000010201/ENSPREG00000021218/ENSPREG00000022921/ENSPREG00000016483/ENSPREG00000017605/ENSPREG00000001336/ENSPREG00000018689/ENSPREG00000003692/ENSPREG00000020801/ENSPREG00000018552/ENSPREG00000017873/ENSPREG00000001741/ENSPREG00000022183/ENSPREG00000008213/ENSPREG00000002702/ENSPREG00000001939/ENSPREG00000008843/ENSPREG00000010997/ENSPREG00000012330/ENSPREG00000004374/ENSPREG00000010863/ENSPREG00000010771/ENSPREG00000022527/ENSPREG00000018757/ENSPREG00000014183/ENSPREG00000007319/ENSPREG00000008228/ENSPREG00000014668/ENSPREG00000017111/ENSPREG00000010516/ENSPREG00000022428/ENSPREG00000016577/ENSPREG00000010544/ENSPREG00000007496/ENSPREG00000021395/ENSPREG00000019656/ENSPREG00000022918/ENSPREG00000003604/ENSPREG00000005687/ENSPREG00000021439/ENSPREG00000021750/ENSPREG00000010047/ENSPREG00000018719/ENSPREG00000009526/ENSPREG00000021744/ENSPREG00000019860/ENSPREG00000008668/ENSPREG00000011196/ENSPREG00000019165/ENSPREG00000023240/ENSPREG00000009737/ENSPREG00000005820/ENSPREG00000016961/ENSPREG00000013496/ENSPREG00000016138/ENSPREG00000002905/ENSPREG00000004060/ENSPREG00000004632/ENSPREG00000015216/ENSPREG00000021179/ENSPREG00000003815/ENSPREG00000010951/ENSPREG00000002185/ENSPREG00000021321/ENSPREG00000000207/ENSPREG00000010817/ENSPREG00000011250/ENSPREG00000006378/ENSPREG00000008623/ENSPREG00000011108/ENSPREG00000001610/ENSPREG00000017365/ENSPREG00000021629/ENSPREG00000008027/ENSPREG00000020125/ENSPREG00000002598/ENSPREG00000014968/ENSPREG00000022018/ENSPREG00000002758/ENSPREG00000010975/ENSPREG00000017042/ENSPREG00000020542/ENSPREG00000005920/ENSPREG00000018229/ENSPREG00000019248/ENSPREG00000015541/ENSPREG00000022877/ENSPREG00000017095/ENSPREG00000008883/ENSPREG00000013631/ENSPREG00000020815/ENSPREG00000010793/ENSPREG00000020669/ENSPREG00000004391/ENSPREG00000002967/ENSPREG00000005457/ENSPREG00000015354/ENSPREG00000015192/ENSPREG00000002278/ENSPREG00000005450/ENSPREG00000012757/ENSPREG00000010745/ENSPREG00000000552/ENSPREG00000000614/ENSPREG00000008118/ENSPREG00000004233/ENSPREG00000000631/ENSPREG00000000664/ENSPREG00000017335/ENSPREG00000016007/ENSPREG00000015635/ENSPREG00000015338/ENSPREG00000018217/ENSPREG00000012544/ENSPREG00000021825/ENSPREG00000014040/ENSPREG00000023051/ENSPREG00000015389/ENSPREG00000012225/ENSPREG00000012158/ENSPREG00000013793/ENSPREG00000006529/ENSPREG00000013710/ENSPREG00000012958/ENSPREG00000003820/ENSPREG00000013129/ENSPREG00000002655/ENSPREG00000020433/ENSPREG00000019331/ENSPREG00000018661/ENSPREG00000007988/ENSPREG00000021217/ENSPREG00000005412/ENSPREG00000002047/ENSPREG00000018579/ENSPREG00000001094/ENSPREG00000004127/ENSPREG00000006550/ENSPREG00000012463/ENSPREG00000004302/ENSPREG00000009287/ENSPREG00000015411/ENSPREG00000009568/ENSPREG00000020231/ENSPREG00000010237/ENSPREG00000002204/ENSPREG00000007053/ENSPREG00000014117/ENSPREG00000014293/ENSPREG00000008917/ENSPREG00000016312/ENSPREG00000006981/ENSPREG00000008019/ENSPREG00000017396/ENSPREG00000003680/ENSPREG00000020583/ENSPREG00000002932/ENSPREG00000022000/ENSPREG00000008770/ENSPREG00000020152/ENSPREG00000021013/ENSPREG00000017431/ENSPREG00000015390/ENSPREG00000019122/ENSPREG00000005008/ENSPREG00000007168/ENSPREG00000017326/ENSPREG00000004666/ENSPREG00000002137/ENSPREG00000020279/ENSPREG00000005591/ENSPREG00000013171/ENSPREG00000000480/ENSPREG00000020803/ENSPREG00000012665/ENSPREG00000003037/ENSPREG00000017058/ENSPREG00000006578/ENSPREG00000015791/ENSPREG00000001070/ENSPREG00000013800/ENSPREG00000004172/ENSPREG00000006781/ENSPREG00000000452/ENSPREG00000007785/ENSPREG00000000528/ENSPREG00000010535/ENSPREG00000008848/ENSPREG00000022434/ENSPREG00000020590/ENSPREG00000014636/ENSPREG00000012373/ENSPREG00000003236/ENSPREG00000012273/ENSPREG00000018193/ENSPREG00000012401/ENSPREG00000017054/ENSPREG00000008187/ENSPREG00000009677/ENSPREG00000009497/ENSPREG00000002257/ENSPREG00000013980/ENSPREG00000010157/ENSPREG00000009366/ENSPREG00000005211/ENSPREG00000022741/ENSPREG00000018227/ENSPREG00000014532/ENSPREG00000019115/ENSPREG00000023140/ENSPREG00000008410/ENSPREG00000011957/ENSPREG00000009338/ENSPREG00000010850/ENSPREG00000009142/ENSPREG00000002898/ENSPREG00000014206/ENSPREG00000008157/ENSPREG00000005626/ENSPREG00000012024/ENSPREG00000020099/ENSPREG00000015823/ENSPREG00000004259/ENSPREG00000018641/ENSPREG00000010853/ENSPREG00000007682/ENSPREG00000013562/ENSPREG00000000485/ENSPREG00000012569/ENSPREG00000015203/ENSPREG00000000794/ENSPREG00000003169/ENSPREG00000008034/ENSPREG00000010979/ENSPREG00000014824/ENSPREG00000007689/ENSPREG00000016036/ENSPREG00000006583/ENSPREG00000010595/ENSPREG00000012696/ENSPREG00000015391/ENSPREG00000010973/ENSPREG00000008355/ENSPREG00000001918/ENSPREG00000022447/ENSPREG00000014490/ENSPREG00000001407/ENSPREG00000016063/ENSPREG00000020789/ENSPREG00000004395/ENSPREG00000020563/ENSPREG00000002175/ENSPREG00000007271/ENSPREG00000017893/ENSPREG00000011365/ENSPREG00000010886/ENSPREG00000022828/ENSPREG00000014338/ENSPREG00000018900/ENSPREG00000010345/ENSPREG00000000609/ENSPREG00000002053/ENSPREG00000011081/ENSPREG00000019038/ENSPREG00000000688/ENSPREG00000003630/ENSPREG00000022336/ENSPREG00000009089/ENSPREG00000020673/ENSPREG00000002203/ENSPREG00000011959/ENSPREG00000010772/ENSPREG00000018698/ENSPREG00000004325/ENSPREG00000000598/ENSPREG00000004080/ENSPREG00000010346/ENSPREG00000002929
## GO:0005634 nucleus ENSPREG00000022956/ENSPREG00000011953/ENSPREG00000019319/ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000015471/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000000100/ENSPREG00000001369/ENSPREG00000016198/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000005331/ENSPREG00000011568/ENSPREG00000003428/ENSPREG00000018820/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000021152/ENSPREG00000014413/ENSPREG00000021725/ENSPREG00000020093/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000002287/ENSPREG00000012582/ENSPREG00000020193/ENSPREG00000001808/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000005246/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000016347/ENSPREG00000004107/ENSPREG00000001734/ENSPREG00000018881/ENSPREG00000006464/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000014973/ENSPREG00000009674/ENSPREG00000008235/ENSPREG00000019479/ENSPREG00000012868/ENSPREG00000002795/ENSPREG00000021689/ENSPREG00000022924/ENSPREG00000011913/ENSPREG00000000298/ENSPREG00000022703/ENSPREG00000004976/ENSPREG00000019795/ENSPREG00000000313/ENSPREG00000004425/ENSPREG00000021707/ENSPREG00000013048/ENSPREG00000019472/ENSPREG00000000639/ENSPREG00000010086/ENSPREG00000018023/ENSPREG00000018972/ENSPREG00000007715/ENSPREG00000021553/ENSPREG00000016979/ENSPREG00000003658/ENSPREG00000022723/ENSPREG00000014608/ENSPREG00000004390/ENSPREG00000001387/ENSPREG00000011064/ENSPREG00000001742/ENSPREG00000018730/ENSPREG00000004023/ENSPREG00000006460/ENSPREG00000000443/ENSPREG00000012137/ENSPREG00000005042/ENSPREG00000003440/ENSPREG00000021865/ENSPREG00000004029/ENSPREG00000005028/ENSPREG00000016797/ENSPREG00000010250/ENSPREG00000019031/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000021088/ENSPREG00000007722/ENSPREG00000013766/ENSPREG00000015491/ENSPREG00000005599/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000011689/ENSPREG00000020701/ENSPREG00000012325/ENSPREG00000013423/ENSPREG00000021691/ENSPREG00000017021/ENSPREG00000015810/ENSPREG00000016307/ENSPREG00000011212/ENSPREG00000013528/ENSPREG00000012105/ENSPREG00000008389/ENSPREG00000007498/ENSPREG00000016112/ENSPREG00000006945/ENSPREG00000016676/ENSPREG00000022466/ENSPREG00000007342/ENSPREG00000009326/ENSPREG00000000793/ENSPREG00000010244/ENSPREG00000021231/ENSPREG00000022114/ENSPREG00000018272/ENSPREG00000011441/ENSPREG00000014875/ENSPREG00000013058/ENSPREG00000005993/ENSPREG00000019635/ENSPREG00000004345/ENSPREG00000006032/ENSPREG00000006079/ENSPREG00000006544/ENSPREG00000010644/ENSPREG00000008377/ENSPREG00000005482/ENSPREG00000000447/ENSPREG00000016792/ENSPREG00000008274/ENSPREG00000006489/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000002617/ENSPREG00000017582/ENSPREG00000003918/ENSPREG00000015905/ENSPREG00000000593/ENSPREG00000017247/ENSPREG00000011942/ENSPREG00000018564/ENSPREG00000010162/ENSPREG00000013784/ENSPREG00000018925/ENSPREG00000019566/ENSPREG00000008418/ENSPREG00000008711/ENSPREG00000016256/ENSPREG00000022772/ENSPREG00000010684/ENSPREG00000018166/ENSPREG00000018464/ENSPREG00000023206/ENSPREG00000003325/ENSPREG00000020685/ENSPREG00000012541/ENSPREG00000022711/ENSPREG00000023148/ENSPREG00000010768/ENSPREG00000012184/ENSPREG00000011231/ENSPREG00000000290/ENSPREG00000021702/ENSPREG00000015809/ENSPREG00000006880/ENSPREG00000008156/ENSPREG00000015548/ENSPREG00000022552/ENSPREG00000017649/ENSPREG00000015738/ENSPREG00000016534/ENSPREG00000001635/ENSPREG00000015654/ENSPREG00000000386/ENSPREG00000021907/ENSPREG00000022194/ENSPREG00000000414/ENSPREG00000016146/ENSPREG00000003063/ENSPREG00000013804/ENSPREG00000007429/ENSPREG00000022340/ENSPREG00000007244/ENSPREG00000012296/ENSPREG00000014911/ENSPREG00000011868/ENSPREG00000009925/ENSPREG00000009117/ENSPREG00000009024/ENSPREG00000000763/ENSPREG00000013492/ENSPREG00000018266/ENSPREG00000007061/ENSPREG00000004422/ENSPREG00000013858/ENSPREG00000015499/ENSPREG00000015766/ENSPREG00000010135/ENSPREG00000017887/ENSPREG00000014453/ENSPREG00000020764/ENSPREG00000006276/ENSPREG00000002822/ENSPREG00000022206/ENSPREG00000009984/ENSPREG00000013353/ENSPREG00000021982/ENSPREG00000003561/ENSPREG00000015626/ENSPREG00000000378/ENSPREG00000004142/ENSPREG00000022365/ENSPREG00000009357/ENSPREG00000015451/ENSPREG00000013384/ENSPREG00000003987/ENSPREG00000008032/ENSPREG00000004549/ENSPREG00000009008/ENSPREG00000001155/ENSPREG00000023244/ENSPREG00000017352/ENSPREG00000013812/ENSPREG00000015468/ENSPREG00000019200/ENSPREG00000011115/ENSPREG00000014063/ENSPREG00000005130/ENSPREG00000017403/ENSPREG00000022452/ENSPREG00000016470/ENSPREG00000009177/ENSPREG00000020206/ENSPREG00000022223/ENSPREG00000022308/ENSPREG00000003495/ENSPREG00000020471/ENSPREG00000022066/ENSPREG00000000461/ENSPREG00000011877/ENSPREG00000022836/ENSPREG00000004581/ENSPREG00000020157/ENSPREG00000000184/ENSPREG00000008282/ENSPREG00000003434/ENSPREG00000019531/ENSPREG00000021498/ENSPREG00000004768/ENSPREG00000004398/ENSPREG00000010196/ENSPREG00000019774/ENSPREG00000023216/ENSPREG00000018276/ENSPREG00000005380/ENSPREG00000012965/ENSPREG00000002259/ENSPREG00000006758/ENSPREG00000006371/ENSPREG00000021952/ENSPREG00000005932/ENSPREG00000012916/ENSPREG00000018299/ENSPREG00000020189/ENSPREG00000019101/ENSPREG00000005566/ENSPREG00000009731/ENSPREG00000001226/ENSPREG00000016716/ENSPREG00000014803/ENSPREG00000014120/ENSPREG00000015465/ENSPREG00000021052/ENSPREG00000018746/ENSPREG00000016803/ENSPREG00000005385/ENSPREG00000016821/ENSPREG00000015137/ENSPREG00000014657/ENSPREG00000009131/ENSPREG00000011930/ENSPREG00000020291/ENSPREG00000009793/ENSPREG00000010143/ENSPREG00000002926/ENSPREG00000008906/ENSPREG00000008997/ENSPREG00000017605/ENSPREG00000006998/ENSPREG00000021362/ENSPREG00000002753/ENSPREG00000012420/ENSPREG00000008972/ENSPREG00000010182/ENSPREG00000021486/ENSPREG00000020466/ENSPREG00000005945/ENSPREG00000015409/ENSPREG00000008106/ENSPREG00000010863/ENSPREG00000000847/ENSPREG00000008918/ENSPREG00000011687/ENSPREG00000022501/ENSPREG00000022696/ENSPREG00000007149/ENSPREG00000015111/ENSPREG00000007940/ENSPREG00000005157/ENSPREG00000008456/ENSPREG00000008761/ENSPREG00000018719/ENSPREG00000018558/ENSPREG00000020464/ENSPREG00000005278/ENSPREG00000006455/ENSPREG00000011196/ENSPREG00000011189/ENSPREG00000017548/ENSPREG00000016517/ENSPREG00000006631/ENSPREG00000001171/ENSPREG00000004807/ENSPREG00000007784/ENSPREG00000003764/ENSPREG00000018793/ENSPREG00000015189/ENSPREG00000012574/ENSPREG00000001610/ENSPREG00000017365/ENSPREG00000008027/ENSPREG00000014784/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000017666/ENSPREG00000000311/ENSPREG00000016107/ENSPREG00000000434/ENSPREG00000001334/ENSPREG00000018229/ENSPREG00000007173/ENSPREG00000013706/ENSPREG00000008934/ENSPREG00000004357/ENSPREG00000006179/ENSPREG00000010793/ENSPREG00000015981/ENSPREG00000019517/ENSPREG00000006395/ENSPREG00000015043/ENSPREG00000009968/ENSPREG00000011732/ENSPREG00000005552/ENSPREG00000007743/ENSPREG00000021574/ENSPREG00000006372/ENSPREG00000010735/ENSPREG00000004431/ENSPREG00000022407/ENSPREG00000010381/ENSPREG00000018009/ENSPREG00000002047/ENSPREG00000002070/ENSPREG00000015589/ENSPREG00000004545/ENSPREG00000013196/ENSPREG00000011076/ENSPREG00000003192/ENSPREG00000008796/ENSPREG00000010818/ENSPREG00000014115/ENSPREG00000003680/ENSPREG00000016863/ENSPREG00000010451/ENSPREG00000022630/ENSPREG00000019131/ENSPREG00000005038/ENSPREG00000009155/ENSPREG00000005008/ENSPREG00000006819/ENSPREG00000013848/ENSPREG00000013881/ENSPREG00000017058/ENSPREG00000013800/ENSPREG00000000452/ENSPREG00000012578/ENSPREG00000018769/ENSPREG00000006806/ENSPREG00000000741/ENSPREG00000005138/ENSPREG00000011546/ENSPREG00000015736/ENSPREG00000016371/ENSPREG00000015450/ENSPREG00000018193/ENSPREG00000012357/ENSPREG00000018976/ENSPREG00000001380/ENSPREG00000009850/ENSPREG00000019837/ENSPREG00000001459/ENSPREG00000022088/ENSPREG00000017572/ENSPREG00000022410/ENSPREG00000005401/ENSPREG00000018873/ENSPREG00000021337/ENSPREG00000019455/ENSPREG00000009744/ENSPREG00000015203/ENSPREG00000006068/ENSPREG00000000147/ENSPREG00000019962/ENSPREG00000020174/ENSPREG00000013887/ENSPREG00000010102/ENSPREG00000000133/ENSPREG00000001918/ENSPREG00000020443/ENSPREG00000011131/ENSPREG00000019762/ENSPREG00000016063/ENSPREG00000012631/ENSPREG00000011387/ENSPREG00000020789/ENSPREG00000011871/ENSPREG00000005818/ENSPREG00000021516/ENSPREG00000009681/ENSPREG00000018056/ENSPREG00000001047/ENSPREG00000021969/ENSPREG00000007068/ENSPREG00000010174/ENSPREG00000001848/ENSPREG00000005824/ENSPREG00000006796/ENSPREG00000003295/ENSPREG00000009834/ENSPREG00000006388/ENSPREG00000002487/ENSPREG00000018513/ENSPREG00000012719/ENSPREG00000018198/ENSPREG00000018453/ENSPREG00000017721/ENSPREG00000010475/ENSPREG00000010598/ENSPREG00000011959/ENSPREG00000004232
## GO:0007154 cell communication ENSPREG00000020653/ENSPREG00000001141/ENSPREG00000022383/ENSPREG00000019494/ENSPREG00000017358/ENSPREG00000001183/ENSPREG00000012113/ENSPREG00000021249/ENSPREG00000011792/ENSPREG00000020520/ENSPREG00000008751/ENSPREG00000012421/ENSPREG00000004840/ENSPREG00000021525/ENSPREG00000017316/ENSPREG00000004990/ENSPREG00000002598/ENSPREG00000006256/ENSPREG00000000914/ENSPREG00000001496/ENSPREG00000019124
## GO:0032264 IMP salvage ENSPREG00000022253/ENSPREG00000015439/ENSPREG00000003612/ENSPREG00000023054/ENSPREG00000004091/ENSPREG00000011534
## GO:0003690 double-stranded DNA binding ENSPREG00000003088/ENSPREG00000017119/ENSPREG00000015766/ENSPREG00000000378/ENSPREG00000019200/ENSPREG00000021052/ENSPREG00000019537/ENSPREG00000020992
## GO:0006166 purine ribonucleoside salvage ENSPREG00000022253/ENSPREG00000015439/ENSPREG00000003612/ENSPREG00000023054/ENSPREG00000021913
## GO:0032012 regulation of ARF protein signal transduction ENSPREG00000002608/ENSPREG00000003508/ENSPREG00000006506/ENSPREG00000020209/ENSPREG00000020133/ENSPREG00000012759/ENSPREG00000004233/ENSPREG00000003858/ENSPREG00000003037/ENSPREG00000018759
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific ENSPREG00000001369/ENSPREG00000009674/ENSPREG00000022546/ENSPREG00000013985/ENSPREG00000020978/ENSPREG00000008940
## GO:0072015 glomerular visceral epithelial cell development ENSPREG00000010086/ENSPREG00000012932/ENSPREG00000013106/ENSPREG00000019988/ENSPREG00000012296/ENSPREG00000018284/ENSPREG00000000675/ENSPREG00000008063
## GO:0005244 voltage-gated ion channel activity ENSPREG00000023124/ENSPREG00000020645/ENSPREG00000000841/ENSPREG00000019952/ENSPREG00000001983/ENSPREG00000005051/ENSPREG00000008683/ENSPREG00000004407/ENSPREG00000009454/ENSPREG00000016489/ENSPREG00000006682/ENSPREG00000016414/ENSPREG00000004538/ENSPREG00000016824/ENSPREG00000010074/ENSPREG00000015145/ENSPREG00000018495/ENSPREG00000004085/ENSPREG00000017980/ENSPREG00000021042/ENSPREG00000002771/ENSPREG00000008213/ENSPREG00000007555/ENSPREG00000008714/ENSPREG00000013496/ENSPREG00000000384/ENSPREG00000003070/ENSPREG00000022122/ENSPREG00000013671/ENSPREG00000009258/ENSPREG00000009142/ENSPREG00000008157/ENSPREG00000006583/ENSPREG00000006609/ENSPREG00000011081/ENSPREG00000007547
## GO:0034765 regulation of ion transmembrane transport ENSPREG00000023124/ENSPREG00000020645/ENSPREG00000000841/ENSPREG00000019952/ENSPREG00000001983/ENSPREG00000005051/ENSPREG00000008683/ENSPREG00000004407/ENSPREG00000009454/ENSPREG00000016489/ENSPREG00000006682/ENSPREG00000016414/ENSPREG00000004538/ENSPREG00000016824/ENSPREG00000010074/ENSPREG00000015145/ENSPREG00000018495/ENSPREG00000004085/ENSPREG00000017980/ENSPREG00000021042/ENSPREG00000002771/ENSPREG00000008213/ENSPREG00000007555/ENSPREG00000008714/ENSPREG00000013496/ENSPREG00000000384/ENSPREG00000003070/ENSPREG00000022122/ENSPREG00000013671/ENSPREG00000009258/ENSPREG00000009142/ENSPREG00000008157/ENSPREG00000006583/ENSPREG00000006609/ENSPREG00000011081/ENSPREG00000007547
## GO:0003677 DNA binding ENSPREG00000022956/ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000004595/ENSPREG00000011367/ENSPREG00000001369/ENSPREG00000016198/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000003428/ENSPREG00000018820/ENSPREG00000010940/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000014413/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000020394/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000004107/ENSPREG00000018881/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000014960/ENSPREG00000019479/ENSPREG00000002795/ENSPREG00000022924/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000004425/ENSPREG00000012831/ENSPREG00000013048/ENSPREG00000011292/ENSPREG00000018023/ENSPREG00000007715/ENSPREG00000021553/ENSPREG00000022723/ENSPREG00000011064/ENSPREG00000007733/ENSPREG00000004023/ENSPREG00000010341/ENSPREG00000011157/ENSPREG00000006460/ENSPREG00000004029/ENSPREG00000016797/ENSPREG00000015341/ENSPREG00000010250/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000001592/ENSPREG00000013766/ENSPREG00000015491/ENSPREG00000004266/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000002849/ENSPREG00000020701/ENSPREG00000012325/ENSPREG00000021691/ENSPREG00000015810/ENSPREG00000011212/ENSPREG00000012105/ENSPREG00000017347/ENSPREG00000007498/ENSPREG00000006945/ENSPREG00000016676/ENSPREG00000007342/ENSPREG00000009326/ENSPREG00000011441/ENSPREG00000019519/ENSPREG00000013058/ENSPREG00000005993/ENSPREG00000012718/ENSPREG00000008377/ENSPREG00000021474/ENSPREG00000006489/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000017582/ENSPREG00000015905/ENSPREG00000017247/ENSPREG00000011942/ENSPREG00000019566/ENSPREG00000008418/ENSPREG00000016256/ENSPREG00000022772/ENSPREG00000023206/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000023148/ENSPREG00000012184/ENSPREG00000011231/ENSPREG00000000290/ENSPREG00000003558/ENSPREG00000013985/ENSPREG00000017649/ENSPREG00000015738/ENSPREG00000015654/ENSPREG00000022194/ENSPREG00000000414/ENSPREG00000016146/ENSPREG00000003063/ENSPREG00000013804/ENSPREG00000015395/ENSPREG00000022340/ENSPREG00000009925/ENSPREG00000006077/ENSPREG00000020249/ENSPREG00000016663/ENSPREG00000013492/ENSPREG00000007061/ENSPREG00000015499/ENSPREG00000014453/ENSPREG00000006276/ENSPREG00000002822/ENSPREG00000013353/ENSPREG00000020281/ENSPREG00000013213/ENSPREG00000023244/ENSPREG00000013812/ENSPREG00000015468/ENSPREG00000019200/ENSPREG00000011115/ENSPREG00000005130/ENSPREG00000020206/ENSPREG00000010210/ENSPREG00000022066/ENSPREG00000009279/ENSPREG00000004581/ENSPREG00000019531/ENSPREG00000004768/ENSPREG00000010196/ENSPREG00000019774/ENSPREG00000005380/ENSPREG00000012965/ENSPREG00000002259/ENSPREG00000006758/ENSPREG00000009056/ENSPREG00000018299/ENSPREG00000019101/ENSPREG00000009731/ENSPREG00000001226/ENSPREG00000016716/ENSPREG00000014803/ENSPREG00000014120/ENSPREG00000015465/ENSPREG00000021052/ENSPREG00000018746/ENSPREG00000005385/ENSPREG00000016821/ENSPREG00000014657/ENSPREG00000009131/ENSPREG00000011496/ENSPREG00000008402/ENSPREG00000002926/ENSPREG00000006998/ENSPREG00000015289/ENSPREG00000013765/ENSPREG00000012420/ENSPREG00000019537/ENSPREG00000021486/ENSPREG00000020466/ENSPREG00000015409/ENSPREG00000008106/ENSPREG00000010863/ENSPREG00000000847/ENSPREG00000008918/ENSPREG00000022501/ENSPREG00000008761/ENSPREG00000018558/ENSPREG00000000792/ENSPREG00000012765/ENSPREG00000006455/ENSPREG00000004845/ENSPREG00000017548/ENSPREG00000008940/ENSPREG00000006631/ENSPREG00000002181/ENSPREG00000015189/ENSPREG00000017365/ENSPREG00000014784/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000017666/ENSPREG00000000434/ENSPREG00000001334/ENSPREG00000009851/ENSPREG00000006179/ENSPREG00000015043/ENSPREG00000022402/ENSPREG00000011732/ENSPREG00000014207/ENSPREG00000000939/ENSPREG00000013196/ENSPREG00000014115/ENSPREG00000003680/ENSPREG00000008368/ENSPREG00000016863/ENSPREG00000010451/ENSPREG00000022630/ENSPREG00000005038/ENSPREG00000009155/ENSPREG00000006819/ENSPREG00000013623/ENSPREG00000022317/ENSPREG00000009052/ENSPREG00000000949/ENSPREG00000006806/ENSPREG00000008423/ENSPREG00000011546/ENSPREG00000016371/ENSPREG00000018249/ENSPREG00000015450/ENSPREG00000018193/ENSPREG00000018976/ENSPREG00000003016/ENSPREG00000001380/ENSPREG00000009850/ENSPREG00000022088/ENSPREG00000022410/ENSPREG00000018873/ENSPREG00000021337/ENSPREG00000019962/ENSPREG00000017740/ENSPREG00000010102/ENSPREG00000011131/ENSPREG00000019762/ENSPREG00000011387/ENSPREG00000011871/ENSPREG00000009681/ENSPREG00000010174/ENSPREG00000006796/ENSPREG00000009834/ENSPREG00000006388/ENSPREG00000002487/ENSPREG00000012707/ENSPREG00000018453/ENSPREG00000017721/ENSPREG00000011400/ENSPREG00000006239/ENSPREG00000004232
## Count
## GO:0007275 multicellular organism development 134
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 73
## GO:0006355 regulation of transcription, DNA-templated 207
## GO:0005515 protein binding 720
## GO:0005634 nucleus 457
## GO:0007154 cell communication 21
## GO:0032264 IMP salvage 6
## GO:0003690 double-stranded DNA binding 8
## GO:0006166 purine ribonucleoside salvage 5
## GO:0032012 regulation of ARF protein signal transduction 10
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6
## GO:0072015 glomerular visceral epithelial cell development 8
## GO:0005244 voltage-gated ion channel activity 36
## GO:0034765 regulation of ion transmembrane transport 36
## GO:0003677 DNA binding 250c_dn <- enricher(gene = GvL_dn, universe = GvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_dn,15)## ID
## GO:0005096 GTPase activator activity GO:0005096 GTPase activator activity
## GO:0043547 positive regulation of GTPase activity GO:0043547 positive regulation of GTPase activity
## GO:0061053 somite development GO:0061053 somite development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0030027 lamellipodium GO:0030027 lamellipodium
## GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008543 fibroblast growth factor receptor signaling pathway
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0042074 cell migration involved in gastrulation GO:0042074 cell migration involved in gastrulation
## GO:0002574 thrombocyte differentiation GO:0002574 thrombocyte differentiation
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0006940 regulation of smooth muscle contraction GO:0006940 regulation of smooth muscle contraction
## GO:0035198 miRNA binding GO:0035198 miRNA binding
## GO:0035479 angioblast cell migration from lateral mesoderm to midline GO:0035479 angioblast cell migration from lateral mesoderm to midline
## GO:0046580 negative regulation of Ras protein signal transduction GO:0046580 negative regulation of Ras protein signal transduction
## GO:0007266 Rho protein signal transduction GO:0007266 Rho protein signal transduction
## Description
## GO:0005096 GTPase activator activity GO:0005096 GTPase activator activity
## GO:0043547 positive regulation of GTPase activity GO:0043547 positive regulation of GTPase activity
## GO:0061053 somite development GO:0061053 somite development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0030027 lamellipodium GO:0030027 lamellipodium
## GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008543 fibroblast growth factor receptor signaling pathway
## GO:0043087 regulation of GTPase activity GO:0043087 regulation of GTPase activity
## GO:0042074 cell migration involved in gastrulation GO:0042074 cell migration involved in gastrulation
## GO:0002574 thrombocyte differentiation GO:0002574 thrombocyte differentiation
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0006940 regulation of smooth muscle contraction GO:0006940 regulation of smooth muscle contraction
## GO:0035198 miRNA binding GO:0035198 miRNA binding
## GO:0035479 angioblast cell migration from lateral mesoderm to midline GO:0035479 angioblast cell migration from lateral mesoderm to midline
## GO:0046580 negative regulation of Ras protein signal transduction GO:0046580 negative regulation of Ras protein signal transduction
## GO:0007266 Rho protein signal transduction GO:0007266 Rho protein signal transduction
## GeneRatio
## GO:0005096 GTPase activator activity 39/2621
## GO:0043547 positive regulation of GTPase activity 38/2621
## GO:0061053 somite development 10/2621
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 56/2621
## GO:0030027 lamellipodium 14/2621
## GO:0008543 fibroblast growth factor receptor signaling pathway 11/2621
## GO:0043087 regulation of GTPase activity 10/2621
## GO:0042074 cell migration involved in gastrulation 13/2621
## GO:0002574 thrombocyte differentiation 5/2621
## GO:0006357 regulation of transcription by RNA polymerase II 72/2621
## GO:0006940 regulation of smooth muscle contraction 4/2621
## GO:0035198 miRNA binding 4/2621
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 4/2621
## GO:0046580 negative regulation of Ras protein signal transduction 4/2621
## GO:0007266 Rho protein signal transduction 6/2621
## BgRatio
## GO:0005096 GTPase activator activity 146/18091
## GO:0043547 positive regulation of GTPase activity 149/18091
## GO:0061053 somite development 24/18091
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18091
## GO:0030027 lamellipodium 42/18091
## GO:0008543 fibroblast growth factor receptor signaling pathway 30/18091
## GO:0043087 regulation of GTPase activity 27/18091
## GO:0042074 cell migration involved in gastrulation 41/18091
## GO:0002574 thrombocyte differentiation 9/18091
## GO:0006357 regulation of transcription by RNA polymerase II 370/18091
## GO:0006940 regulation of smooth muscle contraction 6/18091
## GO:0035198 miRNA binding 6/18091
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 6/18091
## GO:0046580 negative regulation of Ras protein signal transduction 6/18091
## GO:0007266 Rho protein signal transduction 13/18091
## pvalue
## GO:0005096 GTPase activator activity 7.950108e-05
## GO:0043547 positive regulation of GTPase activity 2.741006e-04
## GO:0061053 somite development 1.117922e-03
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 1.291365e-03
## GO:0030027 lamellipodium 1.681643e-03
## GO:0008543 fibroblast growth factor receptor signaling pathway 2.199833e-03
## GO:0043087 regulation of GTPase activity 3.183034e-03
## GO:0042074 cell migration involved in gastrulation 3.994801e-03
## GO:0002574 thrombocyte differentiation 4.811215e-03
## GO:0006357 regulation of transcription by RNA polymerase II 4.928195e-03
## GO:0006940 regulation of smooth muscle contraction 5.160769e-03
## GO:0035198 miRNA binding 5.160769e-03
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 5.160769e-03
## GO:0046580 negative regulation of Ras protein signal transduction 5.160769e-03
## GO:0007266 Rho protein signal transduction 6.310493e-03
## p.adjust
## GO:0005096 GTPase activator activity 0.1182181
## GO:0043547 positive regulation of GTPase activity 0.2037938
## GO:0061053 somite development 0.4800650
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4800650
## GO:0030027 lamellipodium 0.5001207
## GO:0008543 fibroblast growth factor receptor signaling pathway 0.5451919
## GO:0043087 regulation of GTPase activity 0.5481474
## GO:0042074 cell migration involved in gastrulation 0.5481474
## GO:0002574 thrombocyte differentiation 0.5481474
## GO:0006357 regulation of transcription by RNA polymerase II 0.5481474
## GO:0006940 regulation of smooth muscle contraction 0.5481474
## GO:0035198 miRNA binding 0.5481474
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.5481474
## GO:0046580 negative regulation of Ras protein signal transduction 0.5481474
## GO:0007266 Rho protein signal transduction 0.5947356
## qvalue
## GO:0005096 GTPase activator activity 0.1182181
## GO:0043547 positive regulation of GTPase activity 0.2037938
## GO:0061053 somite development 0.4800650
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.4800650
## GO:0030027 lamellipodium 0.5001207
## GO:0008543 fibroblast growth factor receptor signaling pathway 0.5451919
## GO:0043087 regulation of GTPase activity 0.5481474
## GO:0042074 cell migration involved in gastrulation 0.5481474
## GO:0002574 thrombocyte differentiation 0.5481474
## GO:0006357 regulation of transcription by RNA polymerase II 0.5481474
## GO:0006940 regulation of smooth muscle contraction 0.5481474
## GO:0035198 miRNA binding 0.5481474
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 0.5481474
## GO:0046580 negative regulation of Ras protein signal transduction 0.5481474
## GO:0007266 Rho protein signal transduction 0.5947356
## geneID
## GO:0005096 GTPase activator activity ENSPREG00000021572/ENSPREG00000017857/ENSPREG00000016181/ENSPREG00000005604/ENSPREG00000020745/ENSPREG00000011984/ENSPREG00000021844/ENSPREG00000006159/ENSPREG00000013319/ENSPREG00000002871/ENSPREG00000014012/ENSPREG00000008818/ENSPREG00000004344/ENSPREG00000002721/ENSPREG00000018244/ENSPREG00000008275/ENSPREG00000006302/ENSPREG00000013392/ENSPREG00000008228/ENSPREG00000021641/ENSPREG00000016304/ENSPREG00000009970/ENSPREG00000019122/ENSPREG00000003783/ENSPREG00000010824/ENSPREG00000010160/ENSPREG00000021619/ENSPREG00000010031/ENSPREG00000011216/ENSPREG00000021253/ENSPREG00000006835/ENSPREG00000013232/ENSPREG00000022990/ENSPREG00000017023/ENSPREG00000014752/ENSPREG00000006207/ENSPREG00000003665/ENSPREG00000003620/ENSPREG00000010384
## GO:0043547 positive regulation of GTPase activity ENSPREG00000021572/ENSPREG00000017857/ENSPREG00000016181/ENSPREG00000005604/ENSPREG00000020745/ENSPREG00000011984/ENSPREG00000021844/ENSPREG00000006159/ENSPREG00000013319/ENSPREG00000002871/ENSPREG00000014012/ENSPREG00000008818/ENSPREG00000004344/ENSPREG00000002721/ENSPREG00000018244/ENSPREG00000008275/ENSPREG00000006302/ENSPREG00000013392/ENSPREG00000008228/ENSPREG00000021641/ENSPREG00000016304/ENSPREG00000009970/ENSPREG00000019122/ENSPREG00000003783/ENSPREG00000010824/ENSPREG00000010160/ENSPREG00000021619/ENSPREG00000011216/ENSPREG00000021253/ENSPREG00000006835/ENSPREG00000013232/ENSPREG00000022990/ENSPREG00000017023/ENSPREG00000014752/ENSPREG00000006207/ENSPREG00000003665/ENSPREG00000003620/ENSPREG00000010384
## GO:0061053 somite development ENSPREG00000004106/ENSPREG00000004421/ENSPREG00000019213/ENSPREG00000004734/ENSPREG00000021266/ENSPREG00000019454/ENSPREG00000014243/ENSPREG00000001029/ENSPREG00000019277/ENSPREG00000009696
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000020178/ENSPREG00000001953/ENSPREG00000021717/ENSPREG00000006479/ENSPREG00000005993/ENSPREG00000018520/ENSPREG00000009681/ENSPREG00000006716/ENSPREG00000000920/ENSPREG00000015465/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000017783/ENSPREG00000020332/ENSPREG00000017205/ENSPREG00000014279/ENSPREG00000017596/ENSPREG00000013353/ENSPREG00000013766/ENSPREG00000016234/ENSPREG00000006819/ENSPREG00000020505/ENSPREG00000011391/ENSPREG00000012541/ENSPREG00000005821/ENSPREG00000001364/ENSPREG00000004970/ENSPREG00000022245/ENSPREG00000000568/ENSPREG00000003423/ENSPREG00000006660/ENSPREG00000013636/ENSPREG00000006396/ENSPREG00000020203/ENSPREG00000021337/ENSPREG00000020306/ENSPREG00000004613/ENSPREG00000006276/ENSPREG00000004738/ENSPREG00000000532/ENSPREG00000011115/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000023186/ENSPREG00000021486/ENSPREG00000020365/ENSPREG00000005380/ENSPREG00000021397/ENSPREG00000008763/ENSPREG00000001030/ENSPREG00000018023/ENSPREG00000011303/ENSPREG00000018702/ENSPREG00000017421/ENSPREG00000016284/ENSPREG00000006136
## GO:0030027 lamellipodium ENSPREG00000021380/ENSPREG00000019012/ENSPREG00000009577/ENSPREG00000009614/ENSPREG00000007947/ENSPREG00000004066/ENSPREG00000015792/ENSPREG00000003672/ENSPREG00000014493/ENSPREG00000014544/ENSPREG00000016267/ENSPREG00000019071/ENSPREG00000013594/ENSPREG00000012964
## GO:0008543 fibroblast growth factor receptor signaling pathway ENSPREG00000008601/ENSPREG00000006269/ENSPREG00000001888/ENSPREG00000001509/ENSPREG00000009500/ENSPREG00000009587/ENSPREG00000003136/ENSPREG00000012483/ENSPREG00000021677/ENSPREG00000003394/ENSPREG00000004531
## GO:0043087 regulation of GTPase activity ENSPREG00000021572/ENSPREG00000017857/ENSPREG00000002871/ENSPREG00000014012/ENSPREG00000004344/ENSPREG00000018244/ENSPREG00000021641/ENSPREG00000010824/ENSPREG00000010160/ENSPREG00000011216
## GO:0042074 cell migration involved in gastrulation ENSPREG00000011756/ENSPREG00000021881/ENSPREG00000006621/ENSPREG00000022282/ENSPREG00000004734/ENSPREG00000021266/ENSPREG00000018004/ENSPREG00000014148/ENSPREG00000021914/ENSPREG00000001363/ENSPREG00000021177/ENSPREG00000014260/ENSPREG00000008575
## GO:0002574 thrombocyte differentiation ENSPREG00000005604/ENSPREG00000004637/ENSPREG00000004734/ENSPREG00000021641/ENSPREG00000005463
## GO:0006357 regulation of transcription by RNA polymerase II ENSPREG00000020178/ENSPREG00000001953/ENSPREG00000021717/ENSPREG00000016394/ENSPREG00000000237/ENSPREG00000006479/ENSPREG00000018520/ENSPREG00000009681/ENSPREG00000000103/ENSPREG00000006716/ENSPREG00000000920/ENSPREG00000015465/ENSPREG00000020443/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000017783/ENSPREG00000020332/ENSPREG00000012529/ENSPREG00000017349/ENSPREG00000017205/ENSPREG00000014279/ENSPREG00000017596/ENSPREG00000013353/ENSPREG00000013766/ENSPREG00000006018/ENSPREG00000016234/ENSPREG00000002041/ENSPREG00000007490/ENSPREG00000006819/ENSPREG00000022140/ENSPREG00000020505/ENSPREG00000011391/ENSPREG00000012541/ENSPREG00000005821/ENSPREG00000001364/ENSPREG00000004970/ENSPREG00000019385/ENSPREG00000022245/ENSPREG00000000568/ENSPREG00000003423/ENSPREG00000006660/ENSPREG00000013636/ENSPREG00000008829/ENSPREG00000006396/ENSPREG00000020203/ENSPREG00000021337/ENSPREG00000020306/ENSPREG00000016198/ENSPREG00000004613/ENSPREG00000006276/ENSPREG00000021303/ENSPREG00000004738/ENSPREG00000000447/ENSPREG00000000532/ENSPREG00000011115/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000023186/ENSPREG00000021486/ENSPREG00000020365/ENSPREG00000019566/ENSPREG00000005380/ENSPREG00000018553/ENSPREG00000021397/ENSPREG00000001030/ENSPREG00000011303/ENSPREG00000007804/ENSPREG00000019158/ENSPREG00000018702/ENSPREG00000017421/ENSPREG00000016284/ENSPREG00000006136
## GO:0006940 regulation of smooth muscle contraction ENSPREG00000017046/ENSPREG00000000530/ENSPREG00000019926/ENSPREG00000000294
## GO:0035198 miRNA binding ENSPREG00000020727/ENSPREG00000010315/ENSPREG00000002072/ENSPREG00000017699
## GO:0035479 angioblast cell migration from lateral mesoderm to midline ENSPREG00000004106/ENSPREG00000011756/ENSPREG00000010859/ENSPREG00000011785
## GO:0046580 negative regulation of Ras protein signal transduction ENSPREG00000017857/ENSPREG00000006469/ENSPREG00000004344/ENSPREG00000021641
## GO:0007266 Rho protein signal transduction ENSPREG00000013319/ENSPREG00000009253/ENSPREG00000008275/ENSPREG00000000371/ENSPREG00000017023/ENSPREG00000005721
## Count
## GO:0005096 GTPase activator activity 39
## GO:0043547 positive regulation of GTPase activity 38
## GO:0061053 somite development 10
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 56
## GO:0030027 lamellipodium 14
## GO:0008543 fibroblast growth factor receptor signaling pathway 11
## GO:0043087 regulation of GTPase activity 10
## GO:0042074 cell migration involved in gastrulation 13
## GO:0002574 thrombocyte differentiation 5
## GO:0006357 regulation of transcription by RNA polymerase II 72
## GO:0006940 regulation of smooth muscle contraction 4
## GO:0035198 miRNA binding 4
## GO:0035479 angioblast cell migration from lateral mesoderm to midline 4
## GO:0046580 negative regulation of Ras protein signal transduction 4
## GO:0007266 Rho protein signal transduction 6GvLunion <- union(GvL_up,GvL_dn)
c_union <- enricher(gene = GvLunion, universe = GvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_union,15)## ID
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0005096 GTPase activator activity GO:0005096 GTPase activator activity
## GO:0061053 somite development GO:0061053 somite development
## GO:0043547 positive regulation of GTPase activity GO:0043547 positive regulation of GTPase activity
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0042074 cell migration involved in gastrulation GO:0042074 cell migration involved in gastrulation
## GO:0036342 post-anal tail morphogenesis GO:0036342 post-anal tail morphogenesis
## GO:0005788 endoplasmic reticulum lumen GO:0005788 endoplasmic reticulum lumen
## GO:0006166 purine ribonucleoside salvage GO:0006166 purine ribonucleoside salvage
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0016055 Wnt signaling pathway GO:0016055 Wnt signaling pathway
## GO:0003690 double-stranded DNA binding GO:0003690 double-stranded DNA binding
## GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016651 oxidoreductase activity, acting on NAD(P)H
## Description
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0005096 GTPase activator activity GO:0005096 GTPase activator activity
## GO:0061053 somite development GO:0061053 somite development
## GO:0043547 positive regulation of GTPase activity GO:0043547 positive regulation of GTPase activity
## GO:0005515 protein binding GO:0005515 protein binding
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0042074 cell migration involved in gastrulation GO:0042074 cell migration involved in gastrulation
## GO:0036342 post-anal tail morphogenesis GO:0036342 post-anal tail morphogenesis
## GO:0005788 endoplasmic reticulum lumen GO:0005788 endoplasmic reticulum lumen
## GO:0006166 purine ribonucleoside salvage GO:0006166 purine ribonucleoside salvage
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0016055 Wnt signaling pathway GO:0016055 Wnt signaling pathway
## GO:0003690 double-stranded DNA binding GO:0003690 double-stranded DNA binding
## GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016651 oxidoreductase activity, acting on NAD(P)H
## GeneRatio
## GO:0007275 multicellular organism development 200/5634
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 114/5634
## GO:0005096 GTPase activator activity 67/5634
## GO:0061053 somite development 16/5634
## GO:0043547 positive regulation of GTPase activity 66/5634
## GO:0005515 protein binding 1132/5634
## GO:0006357 regulation of transcription by RNA polymerase II 142/5634
## GO:0042074 cell migration involved in gastrulation 22/5634
## GO:0036342 post-anal tail morphogenesis 10/5634
## GO:0005788 endoplasmic reticulum lumen 14/5634
## GO:0006166 purine ribonucleoside salvage 6/5634
## GO:0006355 regulation of transcription, DNA-templated 308/5634
## GO:0016055 Wnt signaling pathway 42/5634
## GO:0003690 double-stranded DNA binding 10/5634
## GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/5634
## BgRatio
## GO:0007275 multicellular organism development 480/18091
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18091
## GO:0005096 GTPase activator activity 146/18091
## GO:0061053 somite development 24/18091
## GO:0043547 positive regulation of GTPase activity 149/18091
## GO:0005515 protein binding 3397/18091
## GO:0006357 regulation of transcription by RNA polymerase II 370/18091
## GO:0042074 cell migration involved in gastrulation 41/18091
## GO:0036342 post-anal tail morphogenesis 14/18091
## GO:0005788 endoplasmic reticulum lumen 23/18091
## GO:0006166 purine ribonucleoside salvage 7/18091
## GO:0006355 regulation of transcription, DNA-templated 875/18091
## GO:0016055 Wnt signaling pathway 95/18091
## GO:0003690 double-stranded DNA binding 15/18091
## GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/18091
## pvalue
## GO:0007275 multicellular organism development 5.278263e-07
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 9.725663e-06
## GO:0005096 GTPase activator activity 1.241863e-04
## GO:0061053 somite development 3.623042e-04
## GO:0043547 positive regulation of GTPase activity 4.775609e-04
## GO:0005515 protein binding 1.294484e-03
## GO:0006357 regulation of transcription by RNA polymerase II 1.675474e-03
## GO:0042074 cell migration involved in gastrulation 2.239310e-03
## GO:0036342 post-anal tail morphogenesis 2.278580e-03
## GO:0005788 endoplasmic reticulum lumen 3.072221e-03
## GO:0006166 purine ribonucleoside salvage 4.673959e-03
## GO:0006355 regulation of transcription, DNA-templated 4.708250e-03
## GO:0016055 Wnt signaling pathway 4.904310e-03
## GO:0003690 double-stranded DNA binding 4.929906e-03
## GO:0016651 oxidoreductase activity, acting on NAD(P)H 5.414657e-03
## p.adjust
## GO:0007275 multicellular organism development 0.0009215848
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0084905039
## GO:0005096 GTPase activator activity 0.0722763984
## GO:0061053 somite development 0.1581457657
## GO:0043547 positive regulation of GTPase activity 0.1667642787
## GO:0005515 protein binding 0.3766947096
## GO:0006357 regulation of transcription by RNA polymerase II 0.4179111344
## GO:0042074 cell migration involved in gastrulation 0.4420445470
## GO:0036342 post-anal tail morphogenesis 0.4420445470
## GO:0005788 endoplasmic reticulum lumen 0.5364097324
## GO:0006166 purine ribonucleoside salvage 0.6044709455
## GO:0006355 regulation of transcription, DNA-templated 0.6044709455
## GO:0016055 Wnt signaling pathway 0.6044709455
## GO:0003690 double-stranded DNA binding 0.6044709455
## GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.6044709455
## qvalue
## GO:0007275 multicellular organism development 0.0009215848
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0084905039
## GO:0005096 GTPase activator activity 0.0722763984
## GO:0061053 somite development 0.1581457657
## GO:0043547 positive regulation of GTPase activity 0.1667642787
## GO:0005515 protein binding 0.3766947096
## GO:0006357 regulation of transcription by RNA polymerase II 0.4179111344
## GO:0042074 cell migration involved in gastrulation 0.4420445470
## GO:0036342 post-anal tail morphogenesis 0.4420445470
## GO:0005788 endoplasmic reticulum lumen 0.5364097324
## GO:0006166 purine ribonucleoside salvage 0.6044709455
## GO:0006355 regulation of transcription, DNA-templated 0.6044709455
## GO:0016055 Wnt signaling pathway 0.6044709455
## GO:0003690 double-stranded DNA binding 0.6044709455
## GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.6044709455
## geneID
## GO:0007275 multicellular organism development ENSPREG00000020203/ENSPREG00000021322/ENSPREG00000011367/ENSPREG00000001369/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000006315/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000000612/ENSPREG00000002795/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000021144/ENSPREG00000009481/ENSPREG00000018023/ENSPREG00000019494/ENSPREG00000008962/ENSPREG00000016797/ENSPREG00000009349/ENSPREG00000010250/ENSPREG00000011561/ENSPREG00000013766/ENSPREG00000012325/ENSPREG00000015810/ENSPREG00000018652/ENSPREG00000012105/ENSPREG00000017347/ENSPREG00000007498/ENSPREG00000021106/ENSPREG00000006945/ENSPREG00000007342/ENSPREG00000011441/ENSPREG00000013058/ENSPREG00000006544/ENSPREG00000008377/ENSPREG00000005482/ENSPREG00000001072/ENSPREG00000021474/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000017582/ENSPREG00000019060/ENSPREG00000016476/ENSPREG00000016256/ENSPREG00000020385/ENSPREG00000023206/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000000290/ENSPREG00000019816/ENSPREG00000012697/ENSPREG00000022340/ENSPREG00000007061/ENSPREG00000015499/ENSPREG00000006276/ENSPREG00000000081/ENSPREG00000013353/ENSPREG00000012157/ENSPREG00000013812/ENSPREG00000011115/ENSPREG00000020206/ENSPREG00000009183/ENSPREG00000006008/ENSPREG00000018739/ENSPREG00000004544/ENSPREG00000019531/ENSPREG00000019774/ENSPREG00000005380/ENSPREG00000017388/ENSPREG00000006758/ENSPREG00000018360/ENSPREG00000018299/ENSPREG00000014903/ENSPREG00000009731/ENSPREG00000014120/ENSPREG00000020252/ENSPREG00000015465/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000009131/ENSPREG00000004067/ENSPREG00000006998/ENSPREG00000012420/ENSPREG00000015409/ENSPREG00000018757/ENSPREG00000008022/ENSPREG00000016630/ENSPREG00000008761/ENSPREG00000006631/ENSPREG00000015189/ENSPREG00000014784/ENSPREG00000009250/ENSPREG00000017666/ENSPREG00000002598/ENSPREG00000001334/ENSPREG00000010793/ENSPREG00000010872/ENSPREG00000007418/ENSPREG00000018822/ENSPREG00000016622/ENSPREG00000005412/ENSPREG00000018009/ENSPREG00000017718/ENSPREG00000013196/ENSPREG00000006981/ENSPREG00000008184/ENSPREG00000009155/ENSPREG00000006819/ENSPREG00000006806/ENSPREG00000015450/ENSPREG00000018004/ENSPREG00000021337/ENSPREG00000014891/ENSPREG00000002673/ENSPREG00000019962/ENSPREG00000000133/ENSPREG00000001918/ENSPREG00000011131/ENSPREG00000019762/ENSPREG00000009681/ENSPREG00000009942/ENSPREG00000006796/ENSPREG00000006388/ENSPREG00000002053/ENSPREG00000012707/ENSPREG00000019085/ENSPREG00000020178/ENSPREG00000021717/ENSPREG00000006469/ENSPREG00000004106/ENSPREG00000006479/ENSPREG00000011860/ENSPREG00000008534/ENSPREG00000001227/ENSPREG00000008016/ENSPREG00000010790/ENSPREG00000000691/ENSPREG00000018520/ENSPREG00000004862/ENSPREG00000023233/ENSPREG00000006716/ENSPREG00000009823/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000011756/ENSPREG00000001888/ENSPREG00000020332/ENSPREG00000014079/ENSPREG00000006190/ENSPREG00000021652/ENSPREG00000014279/ENSPREG00000017596/ENSPREG00000007694/ENSPREG00000016234/ENSPREG00000012787/ENSPREG00000020505/ENSPREG00000011391/ENSPREG00000008573/ENSPREG00000004734/ENSPREG00000005821/ENSPREG00000001364/ENSPREG00000004970/ENSPREG00000018675/ENSPREG00000013601/ENSPREG00000003672/ENSPREG00000012930/ENSPREG00000003423/ENSPREG00000006660/ENSPREG00000013636/ENSPREG00000006396/ENSPREG00000020306/ENSPREG00000007911/ENSPREG00000004613/ENSPREG00000016694/ENSPREG00000000532/ENSPREG00000006642/ENSPREG00000006326/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000023186/ENSPREG00000012819/ENSPREG00000020365/ENSPREG00000005189/ENSPREG00000017782/ENSPREG00000001030/ENSPREG00000011176/ENSPREG00000005657/ENSPREG00000018702/ENSPREG00000017421/ENSPREG00000008575/ENSPREG00000016284/ENSPREG00000006136
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000006315/ENSPREG00000013067/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000002795/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000018023/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000012325/ENSPREG00000015810/ENSPREG00000012105/ENSPREG00000007498/ENSPREG00000006945/ENSPREG00000011441/ENSPREG00000013058/ENSPREG00000005993/ENSPREG00000008377/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000021630/ENSPREG00000016256/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000000290/ENSPREG00000022340/ENSPREG00000006276/ENSPREG00000013353/ENSPREG00000013812/ENSPREG00000011115/ENSPREG00000019531/ENSPREG00000005380/ENSPREG00000006758/ENSPREG00000015465/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000006998/ENSPREG00000013765/ENSPREG00000012420/ENSPREG00000021486/ENSPREG00000006631/ENSPREG00000015189/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000017666/ENSPREG00000001334/ENSPREG00000015043/ENSPREG00000021574/ENSPREG00000013196/ENSPREG00000009155/ENSPREG00000006819/ENSPREG00000013623/ENSPREG00000000949/ENSPREG00000006806/ENSPREG00000015450/ENSPREG00000021337/ENSPREG00000019962/ENSPREG00000011131/ENSPREG00000009681/ENSPREG00000006796/ENSPREG00000006388/ENSPREG00000020178/ENSPREG00000001953/ENSPREG00000021717/ENSPREG00000006479/ENSPREG00000018520/ENSPREG00000006716/ENSPREG00000000920/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000017783/ENSPREG00000020332/ENSPREG00000017205/ENSPREG00000014279/ENSPREG00000017596/ENSPREG00000016234/ENSPREG00000020505/ENSPREG00000011391/ENSPREG00000005821/ENSPREG00000001364/ENSPREG00000004970/ENSPREG00000022245/ENSPREG00000003423/ENSPREG00000006660/ENSPREG00000013636/ENSPREG00000006396/ENSPREG00000020306/ENSPREG00000004613/ENSPREG00000004738/ENSPREG00000000532/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000023186/ENSPREG00000020365/ENSPREG00000021397/ENSPREG00000008763/ENSPREG00000001030/ENSPREG00000011303/ENSPREG00000018702/ENSPREG00000017421/ENSPREG00000016284/ENSPREG00000006136
## GO:0005096 GTPase activator activity ENSPREG00000009673/ENSPREG00000002248/ENSPREG00000021844/ENSPREG00000013339/ENSPREG00000022339/ENSPREG00000014913/ENSPREG00000006440/ENSPREG00000013046/ENSPREG00000013249/ENSPREG00000021455/ENSPREG00000010031/ENSPREG00000011996/ENSPREG00000009432/ENSPREG00000020745/ENSPREG00000002317/ENSPREG00000013257/ENSPREG00000000815/ENSPREG00000010645/ENSPREG00000014547/ENSPREG00000020238/ENSPREG00000005509/ENSPREG00000008228/ENSPREG00000011216/ENSPREG00000007317/ENSPREG00000011807/ENSPREG00000001605/ENSPREG00000002871/ENSPREG00000022269/ENSPREG00000012301/ENSPREG00000019122/ENSPREG00000003273/ENSPREG00000021572/ENSPREG00000012665/ENSPREG00000000528/ENSPREG00000009884/ENSPREG00000001366/ENSPREG00000017857/ENSPREG00000016181/ENSPREG00000005604/ENSPREG00000011984/ENSPREG00000006159/ENSPREG00000013319/ENSPREG00000014012/ENSPREG00000008818/ENSPREG00000004344/ENSPREG00000002721/ENSPREG00000018244/ENSPREG00000008275/ENSPREG00000006302/ENSPREG00000013392/ENSPREG00000021641/ENSPREG00000016304/ENSPREG00000009970/ENSPREG00000003783/ENSPREG00000010824/ENSPREG00000010160/ENSPREG00000021619/ENSPREG00000021253/ENSPREG00000006835/ENSPREG00000013232/ENSPREG00000022990/ENSPREG00000017023/ENSPREG00000014752/ENSPREG00000006207/ENSPREG00000003665/ENSPREG00000003620/ENSPREG00000010384
## GO:0061053 somite development ENSPREG00000005012/ENSPREG00000006929/ENSPREG00000019213/ENSPREG00000021266/ENSPREG00000014803/ENSPREG00000020705/ENSPREG00000004233/ENSPREG00000003539/ENSPREG00000004106/ENSPREG00000004421/ENSPREG00000004734/ENSPREG00000019454/ENSPREG00000014243/ENSPREG00000001029/ENSPREG00000019277/ENSPREG00000009696
## GO:0043547 positive regulation of GTPase activity ENSPREG00000009673/ENSPREG00000002248/ENSPREG00000021844/ENSPREG00000013339/ENSPREG00000022339/ENSPREG00000014913/ENSPREG00000006440/ENSPREG00000013046/ENSPREG00000013249/ENSPREG00000021455/ENSPREG00000011996/ENSPREG00000009432/ENSPREG00000020745/ENSPREG00000002317/ENSPREG00000013257/ENSPREG00000000815/ENSPREG00000010645/ENSPREG00000014547/ENSPREG00000020238/ENSPREG00000005509/ENSPREG00000008228/ENSPREG00000011216/ENSPREG00000007317/ENSPREG00000011807/ENSPREG00000001605/ENSPREG00000002871/ENSPREG00000022269/ENSPREG00000012301/ENSPREG00000019122/ENSPREG00000003273/ENSPREG00000021572/ENSPREG00000012665/ENSPREG00000000528/ENSPREG00000009884/ENSPREG00000001366/ENSPREG00000017857/ENSPREG00000016181/ENSPREG00000005604/ENSPREG00000011984/ENSPREG00000006159/ENSPREG00000013319/ENSPREG00000014012/ENSPREG00000008818/ENSPREG00000004344/ENSPREG00000002721/ENSPREG00000018244/ENSPREG00000008275/ENSPREG00000006302/ENSPREG00000013392/ENSPREG00000021641/ENSPREG00000016304/ENSPREG00000009970/ENSPREG00000003783/ENSPREG00000010824/ENSPREG00000010160/ENSPREG00000021619/ENSPREG00000021253/ENSPREG00000006835/ENSPREG00000013232/ENSPREG00000022990/ENSPREG00000017023/ENSPREG00000014752/ENSPREG00000006207/ENSPREG00000003665/ENSPREG00000003620/ENSPREG00000010384
## GO:0005515 protein binding 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## GO:0006357 regulation of transcription by RNA polymerase II ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000016198/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000006315/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000017259/ENSPREG00000019479/ENSPREG00000002795/ENSPREG00000000103/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000013994/ENSPREG00000011064/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000012325/ENSPREG00000015810/ENSPREG00000012105/ENSPREG00000007498/ENSPREG00000006945/ENSPREG00000011441/ENSPREG00000013058/ENSPREG00000008377/ENSPREG00000000447/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000015905/ENSPREG00000019566/ENSPREG00000021630/ENSPREG00000016256/ENSPREG00000010684/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000000290/ENSPREG00000006934/ENSPREG00000022340/ENSPREG00000012296/ENSPREG00000009925/ENSPREG00000020764/ENSPREG00000006276/ENSPREG00000013353/ENSPREG00000011115/ENSPREG00000020206/ENSPREG00000003495/ENSPREG00000019531/ENSPREG00000005380/ENSPREG00000006758/ENSPREG00000015465/ENSPREG00000018746/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000006998/ENSPREG00000013765/ENSPREG00000012420/ENSPREG00000019537/ENSPREG00000021486/ENSPREG00000000847/ENSPREG00000006631/ENSPREG00000015189/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000001334/ENSPREG00000015043/ENSPREG00000021574/ENSPREG00000009155/ENSPREG00000006819/ENSPREG00000000949/ENSPREG00000006806/ENSPREG00000015450/ENSPREG00000021337/ENSPREG00000019962/ENSPREG00000020443/ENSPREG00000011131/ENSPREG00000011387/ENSPREG00000010836/ENSPREG00000009681/ENSPREG00000006796/ENSPREG00000006388/ENSPREG00000020178/ENSPREG00000001953/ENSPREG00000021717/ENSPREG00000016394/ENSPREG00000000237/ENSPREG00000006479/ENSPREG00000018520/ENSPREG00000006716/ENSPREG00000000920/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000017783/ENSPREG00000020332/ENSPREG00000012529/ENSPREG00000017349/ENSPREG00000017205/ENSPREG00000014279/ENSPREG00000017596/ENSPREG00000006018/ENSPREG00000016234/ENSPREG00000002041/ENSPREG00000007490/ENSPREG00000022140/ENSPREG00000020505/ENSPREG00000011391/ENSPREG00000005821/ENSPREG00000001364/ENSPREG00000004970/ENSPREG00000019385/ENSPREG00000022245/ENSPREG00000003423/ENSPREG00000006660/ENSPREG00000013636/ENSPREG00000008829/ENSPREG00000006396/ENSPREG00000020306/ENSPREG00000004613/ENSPREG00000021303/ENSPREG00000004738/ENSPREG00000000532/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000023186/ENSPREG00000020365/ENSPREG00000018553/ENSPREG00000021397/ENSPREG00000001030/ENSPREG00000011303/ENSPREG00000007804/ENSPREG00000019158/ENSPREG00000018702/ENSPREG00000017421/ENSPREG00000016284/ENSPREG00000006136
## GO:0042074 cell migration involved in gastrulation ENSPREG00000021266/ENSPREG00000022339/ENSPREG00000005116/ENSPREG00000011942/ENSPREG00000009636/ENSPREG00000018470/ENSPREG00000008022/ENSPREG00000001032/ENSPREG00000018004/ENSPREG00000009850/ENSPREG00000021177/ENSPREG00000009942/ENSPREG00000011756/ENSPREG00000021881/ENSPREG00000006621/ENSPREG00000022282/ENSPREG00000004734/ENSPREG00000014148/ENSPREG00000021914/ENSPREG00000001363/ENSPREG00000014260/ENSPREG00000008575
## GO:0036342 post-anal tail morphogenesis ENSPREG00000021316/ENSPREG00000016545/ENSPREG00000014803/ENSPREG00000006631/ENSPREG00000003680/ENSPREG00000009155/ENSPREG00000007694/ENSPREG00000018936/ENSPREG00000004734/ENSPREG00000008575
## GO:0005788 endoplasmic reticulum lumen ENSPREG00000008313/ENSPREG00000009114/ENSPREG00000016136/ENSPREG00000015396/ENSPREG00000008623/ENSPREG00000003298/ENSPREG00000006623/ENSPREG00000015941/ENSPREG00000010003/ENSPREG00000017433/ENSPREG00000021079/ENSPREG00000014189/ENSPREG00000014288/ENSPREG00000005619
## GO:0006166 purine ribonucleoside salvage ENSPREG00000022253/ENSPREG00000015439/ENSPREG00000003612/ENSPREG00000023054/ENSPREG00000021913/ENSPREG00000003051
## GO:0006355 regulation of transcription, DNA-templated ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000003428/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000005246/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000018881/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000014960/ENSPREG00000002795/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000000313/ENSPREG00000013048/ENSPREG00000010086/ENSPREG00000018023/ENSPREG00000021553/ENSPREG00000022723/ENSPREG00000014608/ENSPREG00000011064/ENSPREG00000014097/ENSPREG00000022546/ENSPREG00000003440/ENSPREG00000004029/ENSPREG00000005028/ENSPREG00000016797/ENSPREG00000010250/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000013766/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000021316/ENSPREG00000012325/ENSPREG00000017021/ENSPREG00000015810/ENSPREG00000013403/ENSPREG00000011212/ENSPREG00000012105/ENSPREG00000007498/ENSPREG00000006945/ENSPREG00000016676/ENSPREG00000007342/ENSPREG00000009326/ENSPREG00000011441/ENSPREG00000019519/ENSPREG00000013058/ENSPREG00000006544/ENSPREG00000008377/ENSPREG00000007906/ENSPREG00000017440/ENSPREG00000011620/ENSPREG00000017582/ENSPREG00000003918/ENSPREG00000015905/ENSPREG00000017247/ENSPREG00000011942/ENSPREG00000010162/ENSPREG00000018925/ENSPREG00000019566/ENSPREG00000021630/ENSPREG00000001543/ENSPREG00000016256/ENSPREG00000022772/ENSPREG00000023206/ENSPREG00000003325/ENSPREG00000012541/ENSPREG00000023148/ENSPREG00000011231/ENSPREG00000000290/ENSPREG00000017649/ENSPREG00000015654/ENSPREG00000016146/ENSPREG00000003063/ENSPREG00000015395/ENSPREG00000018974/ENSPREG00000007429/ENSPREG00000022340/ENSPREG00000011269/ENSPREG00000007997/ENSPREG00000015499/ENSPREG00000017887/ENSPREG00000006276/ENSPREG00000002822/ENSPREG00000013353/ENSPREG00000021982/ENSPREG00000022365/ENSPREG00000010841/ENSPREG00000009008/ENSPREG00000023244/ENSPREG00000017352/ENSPREG00000013812/ENSPREG00000011115/ENSPREG00000022066/ENSPREG00000011877/ENSPREG00000021136/ENSPREG00000019531/ENSPREG00000020804/ENSPREG00000004768/ENSPREG00000004398/ENSPREG00000005380/ENSPREG00000012965/ENSPREG00000002259/ENSPREG00000006758/ENSPREG00000009056/ENSPREG00000009731/ENSPREG00000001226/ENSPREG00000014803/ENSPREG00000015465/ENSPREG00000021052/ENSPREG00000018746/ENSPREG00000005385/ENSPREG00000014657/ENSPREG00000009131/ENSPREG00000011496/ENSPREG00000008402/ENSPREG00000011930/ENSPREG00000022910/ENSPREG00000002926/ENSPREG00000008997/ENSPREG00000006998/ENSPREG00000021362/ENSPREG00000012420/ENSPREG00000008972/ENSPREG00000010182/ENSPREG00000019537/ENSPREG00000020466/ENSPREG00000015409/ENSPREG00000000847/ENSPREG00000008918/ENSPREG00000022501/ENSPREG00000008761/ENSPREG00000018558/ENSPREG00000000792/ENSPREG00000006455/ENSPREG00000011189/ENSPREG00000006631/ENSPREG00000007784/ENSPREG00000015189/ENSPREG00000017365/ENSPREG00000007884/ENSPREG00000014784/ENSPREG00000009250/ENSPREG00000000644/ENSPREG00000017666/ENSPREG00000000434/ENSPREG00000001334/ENSPREG00000015981/ENSPREG00000011732/ENSPREG00000021574/ENSPREG00000014207/ENSPREG00000013196/ENSPREG00000020992/ENSPREG00000010818/ENSPREG00000003680/ENSPREG00000016863/ENSPREG00000022630/ENSPREG00000005038/ENSPREG00000009155/ENSPREG00000005008/ENSPREG00000006819/ENSPREG00000013848/ENSPREG00000013623/ENSPREG00000022317/ENSPREG00000009052/ENSPREG00000010581/ENSPREG00000013800/ENSPREG00000006806/ENSPREG00000011546/ENSPREG00000018249/ENSPREG00000015450/ENSPREG00000018193/ENSPREG00000009850/ENSPREG00000022410/ENSPREG00000021337/ENSPREG00000019455/ENSPREG00000019962/ENSPREG00000010102/ENSPREG00000011131/ENSPREG00000019762/ENSPREG00000011387/ENSPREG00000005818/ENSPREG00000009681/ENSPREG00000018056/ENSPREG00000011677/ENSPREG00000006796/ENSPREG00000006388/ENSPREG00000002487/ENSPREG00000018453/ENSPREG00000011959/ENSPREG00000004232/ENSPREG00000020178/ENSPREG00000001953/ENSPREG00000019840/ENSPREG00000004380/ENSPREG00000021717/ENSPREG00000022182/ENSPREG00000006479/ENSPREG00000015213/ENSPREG00000008224/ENSPREG00000023177/ENSPREG00000023202/ENSPREG00000020875/ENSPREG00000021173/ENSPREG00000000691/ENSPREG00000018520/ENSPREG00000017420/ENSPREG00000004655/ENSPREG00000006716/ENSPREG00000009240/ENSPREG00000005368/ENSPREG00000005374/ENSPREG00000017783/ENSPREG00000014431/ENSPREG00000012138/ENSPREG00000016918/ENSPREG00000020332/ENSPREG00000021778/ENSPREG00000007328/ENSPREG00000006142/ENSPREG00000019735/ENSPREG00000018565/ENSPREG00000003655/ENSPREG00000007793/ENSPREG00000017205/ENSPREG00000014279/ENSPREG00000017596/ENSPREG00000009359/ENSPREG00000016234/ENSPREG00000001598/ENSPREG00000014517/ENSPREG00000013440/ENSPREG00000008720/ENSPREG00000020505/ENSPREG00000011391/ENSPREG00000005821/ENSPREG00000008483/ENSPREG00000023222/ENSPREG00000018134/ENSPREG00000018224/ENSPREG00000001364/ENSPREG00000013420/ENSPREG00000004970/ENSPREG00000013601/ENSPREG00000019385/ENSPREG00000022245/ENSPREG00000003901/ENSPREG00000003423/ENSPREG00000006660/ENSPREG00000009822/ENSPREG00000000204/ENSPREG00000013636/ENSPREG00000008829/ENSPREG00000006396/ENSPREG00000016361/ENSPREG00000020306/ENSPREG00000006034/ENSPREG00000019055/ENSPREG00000013455/ENSPREG00000005784/ENSPREG00000004613/ENSPREG00000019967/ENSPREG00000004738/ENSPREG00000017180/ENSPREG00000014867/ENSPREG00000000532/ENSPREG00000012266/ENSPREG00000005434/ENSPREG00000006326/ENSPREG00000004404/ENSPREG00000000557/ENSPREG00000000563/ENSPREG00000023186/ENSPREG00000015916/ENSPREG00000020365/ENSPREG00000008490/ENSPREG00000000957/ENSPREG00000004772/ENSPREG00000003528/ENSPREG00000005256/ENSPREG00000002132/ENSPREG00000001030/ENSPREG00000009379/ENSPREG00000018100/ENSPREG00000008985/ENSPREG00000011303/ENSPREG00000018702/ENSPREG00000017421/ENSPREG00000014317/ENSPREG00000017478/ENSPREG00000016284/ENSPREG00000006136
## GO:0016055 Wnt signaling pathway ENSPREG00000009481/ENSPREG00000006907/ENSPREG00000011561/ENSPREG00000021316/ENSPREG00000005116/ENSPREG00000021106/ENSPREG00000019060/ENSPREG00000020385/ENSPREG00000020987/ENSPREG00000000958/ENSPREG00000000081/ENSPREG00000018739/ENSPREG00000009636/ENSPREG00000017388/ENSPREG00000014903/ENSPREG00000002723/ENSPREG00000005920/ENSPREG00000017718/ENSPREG00000008184/ENSPREG00000006329/ENSPREG00000000741/ENSPREG00000018004/ENSPREG00000019868/ENSPREG00000002673/ENSPREG00000009942/ENSPREG00000002053/ENSPREG00000011860/ENSPREG00000018405/ENSPREG00000001888/ENSPREG00000014079/ENSPREG00000010495/ENSPREG00000007694/ENSPREG00000022656/ENSPREG00000004734/ENSPREG00000012847/ENSPREG00000002332/ENSPREG00000004323/ENSPREG00000001731/ENSPREG00000020735/ENSPREG00000000736/ENSPREG00000007804/ENSPREG00000011176
## GO:0003690 double-stranded DNA binding ENSPREG00000003088/ENSPREG00000017119/ENSPREG00000015766/ENSPREG00000000378/ENSPREG00000019200/ENSPREG00000021052/ENSPREG00000019537/ENSPREG00000020992/ENSPREG00000022245/ENSPREG00000023099
## GO:0016651 oxidoreductase activity, acting on NAD(P)H ENSPREG00000000871/ENSPREG00000009567/ENSPREG00000005882/ENSPREG00000017416/ENSPREG00000012893/ENSPREG00000011596/ENSPREG00000001667
## Count
## GO:0007275 multicellular organism development 200
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 114
## GO:0005096 GTPase activator activity 67
## GO:0061053 somite development 16
## GO:0043547 positive regulation of GTPase activity 66
## GO:0005515 protein binding 1132
## GO:0006357 regulation of transcription by RNA polymerase II 142
## GO:0042074 cell migration involved in gastrulation 22
## GO:0036342 post-anal tail morphogenesis 10
## GO:0005788 endoplasmic reticulum lumen 14
## GO:0006166 purine ribonucleoside salvage 6
## GO:0006355 regulation of transcription, DNA-templated 308
## GO:0016055 Wnt signaling pathway 42
## GO:0003690 double-stranded DNA binding 10
## GO:0016651 oxidoreductase activity, acting on NAD(P)H 7library(reshape2)
GvL_up <- subset(GvL,meth.diff>0&qvalue<0.001)
GvL_up <- unique(GvL_up$gene_id)
str(GvL_up)## chr [1:833] "ENSPREG00000002699" "ENSPREG00000004582" "ENSPREG00000004594" ...GvL_dn <- subset(GvL,meth.diff<0&qvalue<0.001)
GvL_dn <- unique(GvL_dn$gene_id)
str(CvL_dn)## chr [1:763] "ENSPREG00000014846" "ENSPREG00000010182" "ENSPREG00000012722" ...GvL_bg <- unique(GvL$gene_id)
str(GvL_bg)## chr [1:21615] "ENSPREG00000021468" "ENSPREG00000021490" ...c_up <- enricher(gene = GvL_up, universe = GvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_up,15)## ID
## GO:0030168 platelet activation GO:0030168 platelet activation
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
## GO:0030182 neuron differentiation GO:0030182 neuron differentiation
## GO:0016567 protein ubiquitination GO:0016567 protein ubiquitination
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0061053 somite development GO:0061053 somite development
## GO:0000439 transcription factor TFIIH core complex GO:0000439 transcription factor TFIIH core complex
## GO:0003160 endocardium morphogenesis GO:0003160 endocardium morphogenesis
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## Description
## GO:0030168 platelet activation GO:0030168 platelet activation
## GO:0003677 DNA binding GO:0003677 DNA binding
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0006357 regulation of transcription by RNA polymerase II GO:0006357 regulation of transcription by RNA polymerase II
## GO:0006355 regulation of transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
## GO:0007275 multicellular organism development GO:0007275 multicellular organism development
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
## GO:0030182 neuron differentiation GO:0030182 neuron differentiation
## GO:0016567 protein ubiquitination GO:0016567 protein ubiquitination
## GO:0005634 nucleus GO:0005634 nucleus
## GO:0003700 DNA-binding transcription factor activity GO:0003700 DNA-binding transcription factor activity
## GO:0061053 somite development GO:0061053 somite development
## GO:0000439 transcription factor TFIIH core complex GO:0000439 transcription factor TFIIH core complex
## GO:0003160 endocardium morphogenesis GO:0003160 endocardium morphogenesis
## GO:0006384 transcription initiation from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter
## GeneRatio
## GO:0030168 platelet activation 4/712
## GO:0003677 DNA binding 68/712
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 22/712
## GO:0006357 regulation of transcription by RNA polymerase II 26/712
## GO:0006355 regulation of transcription, DNA-templated 51/712
## GO:0007275 multicellular organism development 31/712
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3/712
## GO:0030182 neuron differentiation 4/712
## GO:0016567 protein ubiquitination 18/712
## GO:0005634 nucleus 104/712
## GO:0003700 DNA-binding transcription factor activity 29/712
## GO:0061053 somite development 4/712
## GO:0000439 transcription factor TFIIH core complex 2/712
## GO:0003160 endocardium morphogenesis 2/712
## GO:0006384 transcription initiation from RNA polymerase III promoter 2/712
## BgRatio
## GO:0030168 platelet activation 7/18091
## GO:0003677 DNA binding 1131/18091
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18091
## GO:0006357 regulation of transcription by RNA polymerase II 370/18091
## GO:0006355 regulation of transcription, DNA-templated 875/18091
## GO:0007275 multicellular organism development 480/18091
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 10/18091
## GO:0030182 neuron differentiation 20/18091
## GO:0016567 protein ubiquitination 242/18091
## GO:0005634 nucleus 2108/18091
## GO:0003700 DNA-binding transcription factor activity 463/18091
## GO:0061053 somite development 24/18091
## GO:0000439 transcription factor TFIIH core complex 5/18091
## GO:0003160 endocardium morphogenesis 5/18091
## GO:0006384 transcription initiation from RNA polymerase III promoter 5/18091
## pvalue
## GO:0030168 platelet activation 7.572133e-05
## GO:0003677 DNA binding 3.143756e-04
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 6.437373e-04
## GO:0006357 regulation of transcription by RNA polymerase II 3.243720e-03
## GO:0006355 regulation of transcription, DNA-templated 3.310674e-03
## GO:0007275 multicellular organism development 4.921780e-03
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 5.919894e-03
## GO:0030182 neuron differentiation 6.966722e-03
## GO:0016567 protein ubiquitination 7.460950e-03
## GO:0005634 nucleus 8.546049e-03
## GO:0003700 DNA-binding transcription factor activity 9.576247e-03
## GO:0061053 somite development 1.349559e-02
## GO:0000439 transcription factor TFIIH core complex 1.428954e-02
## GO:0003160 endocardium morphogenesis 1.428954e-02
## GO:0006384 transcription initiation from RNA polymerase III promoter 1.428954e-02
## p.adjust
## GO:0030168 platelet activation 0.06194005
## GO:0003677 DNA binding 0.12857964
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.17552570
## GO:0006357 regulation of transcription by RNA polymerase II 0.52170357
## GO:0006355 regulation of transcription, DNA-templated 0.52170357
## GO:0007275 multicellular organism development 0.52170357
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 0.52170357
## GO:0030182 neuron differentiation 0.52170357
## GO:0016567 protein ubiquitination 0.52170357
## GO:0005634 nucleus 0.52170357
## GO:0003700 DNA-binding transcription factor activity 0.52170357
## GO:0061053 somite development 0.52170357
## GO:0000439 transcription factor TFIIH core complex 0.52170357
## GO:0003160 endocardium morphogenesis 0.52170357
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.52170357
## qvalue
## GO:0030168 platelet activation 0.05970029
## GO:0003677 DNA binding 0.12393019
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.16917867
## GO:0006357 regulation of transcription by RNA polymerase II 0.50283872
## GO:0006355 regulation of transcription, DNA-templated 0.50283872
## GO:0007275 multicellular organism development 0.50283872
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 0.50283872
## GO:0030182 neuron differentiation 0.50283872
## GO:0016567 protein ubiquitination 0.50283872
## GO:0005634 nucleus 0.50283872
## GO:0003700 DNA-binding transcription factor activity 0.50283872
## GO:0061053 somite development 0.50283872
## GO:0000439 transcription factor TFIIH core complex 0.50283872
## GO:0003160 endocardium morphogenesis 0.50283872
## GO:0006384 transcription initiation from RNA polymerase III promoter 0.50283872
## geneID
## GO:0030168 platelet activation ENSPREG00000017046/ENSPREG00000014506/ENSPREG00000000530/ENSPREG00000002789
## GO:0003677 DNA binding ENSPREG00000022956/ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000004595/ENSPREG00000011367/ENSPREG00000001369/ENSPREG00000016198/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000003428/ENSPREG00000018820/ENSPREG00000010940/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000014413/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000020394/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000004107/ENSPREG00000018881/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000014960/ENSPREG00000019479/ENSPREG00000002795/ENSPREG00000022924/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000004425/ENSPREG00000012831/ENSPREG00000013048/ENSPREG00000011292/ENSPREG00000018023/ENSPREG00000007715/ENSPREG00000021553/ENSPREG00000022723/ENSPREG00000011064/ENSPREG00000007733/ENSPREG00000004023/ENSPREG00000010341/ENSPREG00000011157/ENSPREG00000006460/ENSPREG00000004029/ENSPREG00000016797/ENSPREG00000015341/ENSPREG00000010250/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000001592/ENSPREG00000013766/ENSPREG00000015491/ENSPREG00000004266/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000002849/ENSPREG00000020701/ENSPREG00000012325/ENSPREG00000021691
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000006315/ENSPREG00000013067/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000002795/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000018023/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000012325
## GO:0006357 regulation of transcription by RNA polymerase II ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000016198/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000006315/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000017259/ENSPREG00000019479/ENSPREG00000002795/ENSPREG00000000103/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000013994/ENSPREG00000011064/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000012325
## GO:0006355 regulation of transcription, DNA-templated ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000003428/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000005246/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000018881/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000014960/ENSPREG00000002795/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000000313/ENSPREG00000013048/ENSPREG00000010086/ENSPREG00000018023/ENSPREG00000021553/ENSPREG00000022723/ENSPREG00000014608/ENSPREG00000011064/ENSPREG00000014097/ENSPREG00000022546/ENSPREG00000003440/ENSPREG00000004029/ENSPREG00000005028/ENSPREG00000016797/ENSPREG00000010250/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000013766/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000021316/ENSPREG00000012325/ENSPREG00000017021
## GO:0007275 multicellular organism development ENSPREG00000020203/ENSPREG00000021322/ENSPREG00000011367/ENSPREG00000001369/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000012582/ENSPREG00000006315/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000000612/ENSPREG00000002795/ENSPREG00000011913/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000021144/ENSPREG00000009481/ENSPREG00000018023/ENSPREG00000019494/ENSPREG00000008962/ENSPREG00000016797/ENSPREG00000009349/ENSPREG00000010250/ENSPREG00000011561/ENSPREG00000013766/ENSPREG00000012325
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific ENSPREG00000001369/ENSPREG00000009674/ENSPREG00000022546
## GO:0030182 neuron differentiation ENSPREG00000009674/ENSPREG00000014608/ENSPREG00000019835/ENSPREG00000008962
## GO:0016567 protein ubiquitination ENSPREG00000018477/ENSPREG00000001335/ENSPREG00000016377/ENSPREG00000010792/ENSPREG00000001734/ENSPREG00000020741/ENSPREG00000018515/ENSPREG00000013944/ENSPREG00000009666/ENSPREG00000013726/ENSPREG00000010064/ENSPREG00000004736/ENSPREG00000022808/ENSPREG00000013695/ENSPREG00000005123/ENSPREG00000007331/ENSPREG00000022594/ENSPREG00000013298
## GO:0005634 nucleus ENSPREG00000022956/ENSPREG00000011953/ENSPREG00000019319/ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000015471/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000000100/ENSPREG00000001369/ENSPREG00000016198/ENSPREG00000004628/ENSPREG00000006929/ENSPREG00000005331/ENSPREG00000011568/ENSPREG00000003428/ENSPREG00000018820/ENSPREG00000007900/ENSPREG00000011918/ENSPREG00000021152/ENSPREG00000014413/ENSPREG00000021725/ENSPREG00000020093/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000003088/ENSPREG00000006767/ENSPREG00000002287/ENSPREG00000012582/ENSPREG00000020193/ENSPREG00000001808/ENSPREG00000006315/ENSPREG00000000922/ENSPREG00000005246/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000016347/ENSPREG00000004107/ENSPREG00000001734/ENSPREG00000018881/ENSPREG00000006464/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000014973/ENSPREG00000009674/ENSPREG00000008235/ENSPREG00000019479/ENSPREG00000012868/ENSPREG00000002795/ENSPREG00000021689/ENSPREG00000022924/ENSPREG00000011913/ENSPREG00000000298/ENSPREG00000022703/ENSPREG00000004976/ENSPREG00000019795/ENSPREG00000000313/ENSPREG00000004425/ENSPREG00000021707/ENSPREG00000013048/ENSPREG00000019472/ENSPREG00000000639/ENSPREG00000010086/ENSPREG00000018023/ENSPREG00000018972/ENSPREG00000007715/ENSPREG00000021553/ENSPREG00000016979/ENSPREG00000003658/ENSPREG00000022723/ENSPREG00000014608/ENSPREG00000004390/ENSPREG00000001387/ENSPREG00000011064/ENSPREG00000001742/ENSPREG00000018730/ENSPREG00000004023/ENSPREG00000006460/ENSPREG00000000443/ENSPREG00000012137/ENSPREG00000005042/ENSPREG00000003440/ENSPREG00000021865/ENSPREG00000004029/ENSPREG00000005028/ENSPREG00000016797/ENSPREG00000010250/ENSPREG00000019031/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000021088/ENSPREG00000007722/ENSPREG00000013766/ENSPREG00000015491/ENSPREG00000005599/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000011689/ENSPREG00000020701/ENSPREG00000012325/ENSPREG00000013423/ENSPREG00000021691/ENSPREG00000017021
## GO:0003700 DNA-binding transcription factor activity ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000004628/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000000922/ENSPREG00000013067/ENSPREG00000022267/ENSPREG00000009351/ENSPREG00000018881/ENSPREG00000000568/ENSPREG00000009674/ENSPREG00000011913/ENSPREG00000010086/ENSPREG00000021553/ENSPREG00000022723/ENSPREG00000011064/ENSPREG00000010341/ENSPREG00000004029/ENSPREG00000016797/ENSPREG00000013386/ENSPREG00000017016/ENSPREG00000013766/ENSPREG00000008667/ENSPREG00000008815/ENSPREG00000017021
## GO:0061053 somite development ENSPREG00000005012/ENSPREG00000006929/ENSPREG00000019213/ENSPREG00000021266
## GO:0000439 transcription factor TFIIH core complex ENSPREG00000012137/ENSPREG00000013423
## GO:0003160 endocardium morphogenesis ENSPREG00000006929/ENSPREG00000008747
## GO:0006384 transcription initiation from RNA polymerase III promoter ENSPREG00000021756/ENSPREG00000021691
## Count
## GO:0030168 platelet activation 4
## GO:0003677 DNA binding 68
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 22
## GO:0006357 regulation of transcription by RNA polymerase II 26
## GO:0006355 regulation of transcription, DNA-templated 51
## GO:0007275 multicellular organism development 31
## GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3
## GO:0030182 neuron differentiation 4
## GO:0016567 protein ubiquitination 18
## GO:0005634 nucleus 104
## GO:0003700 DNA-binding transcription factor activity 29
## GO:0061053 somite development 4
## GO:0000439 transcription factor TFIIH core complex 2
## GO:0003160 endocardium morphogenesis 2
## GO:0006384 transcription initiation from RNA polymerase III promoter 2c_dn <- enricher(gene = GvL_dn, universe = GvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_dn,15)## ID
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0001676 long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process
## GO:0004467 long-chain fatty acid-CoA ligase activity GO:0004467 long-chain fatty acid-CoA ligase activity
## GO:0015908 fatty acid transport GO:0015908 fatty acid transport
## GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity
## GO:0060319 primitive erythrocyte differentiation GO:0060319 primitive erythrocyte differentiation
## GO:0030424 axon GO:0030424 axon
## GO:0005882 intermediate filament GO:0005882 intermediate filament
## GO:0006699 bile acid biosynthetic process GO:0006699 bile acid biosynthetic process
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
## GO:0035198 miRNA binding GO:0035198 miRNA binding
## GO:0046580 negative regulation of Ras protein signal transduction GO:0046580 negative regulation of Ras protein signal transduction
## GO:0005861 troponin complex GO:0005861 troponin complex
## GO:0005666 RNA polymerase III complex GO:0005666 RNA polymerase III complex
## GO:0031076 embryonic camera-type eye development GO:0031076 embryonic camera-type eye development
## Description
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0001676 long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process
## GO:0004467 long-chain fatty acid-CoA ligase activity GO:0004467 long-chain fatty acid-CoA ligase activity
## GO:0015908 fatty acid transport GO:0015908 fatty acid transport
## GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity
## GO:0060319 primitive erythrocyte differentiation GO:0060319 primitive erythrocyte differentiation
## GO:0030424 axon GO:0030424 axon
## GO:0005882 intermediate filament GO:0005882 intermediate filament
## GO:0006699 bile acid biosynthetic process GO:0006699 bile acid biosynthetic process
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
## GO:0035198 miRNA binding GO:0035198 miRNA binding
## GO:0046580 negative regulation of Ras protein signal transduction GO:0046580 negative regulation of Ras protein signal transduction
## GO:0005861 troponin complex GO:0005861 troponin complex
## GO:0005666 RNA polymerase III complex GO:0005666 RNA polymerase III complex
## GO:0031076 embryonic camera-type eye development GO:0031076 embryonic camera-type eye development
## GeneRatio
## GO:0015245 fatty acid transmembrane transporter activity 3/469
## GO:0001676 long-chain fatty acid metabolic process 3/469
## GO:0004467 long-chain fatty acid-CoA ligase activity 3/469
## GO:0015908 fatty acid transport 3/469
## GO:0031957 very long-chain fatty acid-CoA ligase activity 3/469
## GO:0060319 primitive erythrocyte differentiation 3/469
## GO:0030424 axon 4/469
## GO:0005882 intermediate filament 5/469
## GO:0006699 bile acid biosynthetic process 2/469
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 2/469
## GO:0035198 miRNA binding 2/469
## GO:0046580 negative regulation of Ras protein signal transduction 2/469
## GO:0005861 troponin complex 3/469
## GO:0005666 RNA polymerase III complex 2/469
## GO:0031076 embryonic camera-type eye development 2/469
## BgRatio
## GO:0015245 fatty acid transmembrane transporter activity 6/18091
## GO:0001676 long-chain fatty acid metabolic process 7/18091
## GO:0004467 long-chain fatty acid-CoA ligase activity 7/18091
## GO:0015908 fatty acid transport 7/18091
## GO:0031957 very long-chain fatty acid-CoA ligase activity 7/18091
## GO:0060319 primitive erythrocyte differentiation 10/18091
## GO:0030424 axon 29/18091
## GO:0005882 intermediate filament 49/18091
## GO:0006699 bile acid biosynthetic process 6/18091
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 6/18091
## GO:0035198 miRNA binding 6/18091
## GO:0046580 negative regulation of Ras protein signal transduction 6/18091
## GO:0005861 troponin complex 19/18091
## GO:0005666 RNA polymerase III complex 7/18091
## GO:0031076 embryonic camera-type eye development 7/18091
## pvalue
## GO:0015245 fatty acid transmembrane transporter activity 0.0003266341
## GO:0001676 long-chain fatty acid metabolic process 0.0005606072
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.0005606072
## GO:0015908 fatty acid transport 0.0005606072
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.0005606072
## GO:0060319 primitive erythrocyte differentiation 0.0018134911
## GO:0030424 axon 0.0063360450
## GO:0005882 intermediate filament 0.0085587464
## GO:0006699 bile acid biosynthetic process 0.0093874551
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 0.0093874551
## GO:0035198 miRNA binding 0.0093874551
## GO:0046580 negative regulation of Ras protein signal transduction 0.0093874551
## GO:0005861 troponin complex 0.0123167824
## GO:0005666 RNA polymerase III complex 0.0129181942
## GO:0031076 embryonic camera-type eye development 0.0129181942
## p.adjust
## GO:0015245 fatty acid transmembrane transporter activity 0.07556985
## GO:0001676 long-chain fatty acid metabolic process 0.07556985
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.07556985
## GO:0015908 fatty acid transport 0.07556985
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.07556985
## GO:0060319 primitive erythrocyte differentiation 0.20371550
## GO:0030424 axon 0.52726206
## GO:0005882 intermediate filament 0.52726206
## GO:0006699 bile acid biosynthetic process 0.52726206
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 0.52726206
## GO:0035198 miRNA binding 0.52726206
## GO:0046580 negative regulation of Ras protein signal transduction 0.52726206
## GO:0005861 troponin complex 0.55284905
## GO:0005666 RNA polymerase III complex 0.55284905
## GO:0031076 embryonic camera-type eye development 0.55284905
## qvalue
## GO:0015245 fatty acid transmembrane transporter activity 0.07494433
## GO:0001676 long-chain fatty acid metabolic process 0.07494433
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.07494433
## GO:0015908 fatty acid transport 0.07494433
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.07494433
## GO:0060319 primitive erythrocyte differentiation 0.20202928
## GO:0030424 axon 0.52289772
## GO:0005882 intermediate filament 0.52289772
## GO:0006699 bile acid biosynthetic process 0.52289772
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 0.52289772
## GO:0035198 miRNA binding 0.52289772
## GO:0046580 negative regulation of Ras protein signal transduction 0.52289772
## GO:0005861 troponin complex 0.54827291
## GO:0005666 RNA polymerase III complex 0.54827291
## GO:0031076 embryonic camera-type eye development 0.54827291
## geneID
## GO:0015245 fatty acid transmembrane transporter activity ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0001676 long-chain fatty acid metabolic process ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0004467 long-chain fatty acid-CoA ligase activity ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0015908 fatty acid transport ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0031957 very long-chain fatty acid-CoA ligase activity ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0060319 primitive erythrocyte differentiation ENSPREG00000001746/ENSPREG00000008016/ENSPREG00000000691
## GO:0030424 axon ENSPREG00000012047/ENSPREG00000011648/ENSPREG00000011984/ENSPREG00000001885
## GO:0005882 intermediate filament ENSPREG00000012716/ENSPREG00000002921/ENSPREG00000000456/ENSPREG00000010040/ENSPREG00000001885
## GO:0006699 bile acid biosynthetic process ENSPREG00000018896/ENSPREG00000015498
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ENSPREG00000012212/ENSPREG00000010341
## GO:0035198 miRNA binding ENSPREG00000020727/ENSPREG00000010315
## GO:0046580 negative regulation of Ras protein signal transduction ENSPREG00000017857/ENSPREG00000006469
## GO:0005861 troponin complex ENSPREG00000003081/ENSPREG00000018442/ENSPREG00000002040
## GO:0005666 RNA polymerase III complex ENSPREG00000015562/ENSPREG00000007275
## GO:0031076 embryonic camera-type eye development ENSPREG00000008541/ENSPREG00000004106
## Count
## GO:0015245 fatty acid transmembrane transporter activity 3
## GO:0001676 long-chain fatty acid metabolic process 3
## GO:0004467 long-chain fatty acid-CoA ligase activity 3
## GO:0015908 fatty acid transport 3
## GO:0031957 very long-chain fatty acid-CoA ligase activity 3
## GO:0060319 primitive erythrocyte differentiation 3
## GO:0030424 axon 4
## GO:0005882 intermediate filament 5
## GO:0006699 bile acid biosynthetic process 2
## GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 2
## GO:0035198 miRNA binding 2
## GO:0046580 negative regulation of Ras protein signal transduction 2
## GO:0005861 troponin complex 3
## GO:0005666 RNA polymerase III complex 2
## GO:0031076 embryonic camera-type eye development 2GvLunion <- union(GvL_up,GvL_dn)
c_union <- enricher(gene = GvLunion, universe = GvL_bg, minGSSize = 5, maxGSSize = 5000, TERM2GENE = mysetsdf, pvalueCutoff = 1, qvalueCutoff = 1)
head(c_union,15)## ID
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0001676 long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process
## GO:0004467 long-chain fatty acid-CoA ligase activity GO:0004467 long-chain fatty acid-CoA ligase activity
## GO:0015908 fatty acid transport GO:0015908 fatty acid transport
## GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity
## GO:0006699 bile acid biosynthetic process GO:0006699 bile acid biosynthetic process
## GO:0030168 platelet activation GO:0030168 platelet activation
## GO:0047834 D-threo-aldose 1-dehydrogenase activity GO:0047834 D-threo-aldose 1-dehydrogenase activity
## GO:0021508 floor plate formation GO:0021508 floor plate formation
## GO:0030182 neuron differentiation GO:0030182 neuron differentiation
## GO:0031076 embryonic camera-type eye development GO:0031076 embryonic camera-type eye development
## GO:0055002 striated muscle cell development GO:0055002 striated muscle cell development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0008217 regulation of blood pressure GO:0008217 regulation of blood pressure
## GO:0005515 protein binding GO:0005515 protein binding
## Description
## GO:0015245 fatty acid transmembrane transporter activity GO:0015245 fatty acid transmembrane transporter activity
## GO:0001676 long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process
## GO:0004467 long-chain fatty acid-CoA ligase activity GO:0004467 long-chain fatty acid-CoA ligase activity
## GO:0015908 fatty acid transport GO:0015908 fatty acid transport
## GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity
## GO:0006699 bile acid biosynthetic process GO:0006699 bile acid biosynthetic process
## GO:0030168 platelet activation GO:0030168 platelet activation
## GO:0047834 D-threo-aldose 1-dehydrogenase activity GO:0047834 D-threo-aldose 1-dehydrogenase activity
## GO:0021508 floor plate formation GO:0021508 floor plate formation
## GO:0030182 neuron differentiation GO:0030182 neuron differentiation
## GO:0031076 embryonic camera-type eye development GO:0031076 embryonic camera-type eye development
## GO:0055002 striated muscle cell development GO:0055002 striated muscle cell development
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
## GO:0008217 regulation of blood pressure GO:0008217 regulation of blood pressure
## GO:0005515 protein binding GO:0005515 protein binding
## GeneRatio
## GO:0015245 fatty acid transmembrane transporter activity 5/1157
## GO:0001676 long-chain fatty acid metabolic process 5/1157
## GO:0004467 long-chain fatty acid-CoA ligase activity 5/1157
## GO:0015908 fatty acid transport 5/1157
## GO:0031957 very long-chain fatty acid-CoA ligase activity 5/1157
## GO:0006699 bile acid biosynthetic process 4/1157
## GO:0030168 platelet activation 4/1157
## GO:0047834 D-threo-aldose 1-dehydrogenase activity 5/1157
## GO:0021508 floor plate formation 3/1157
## GO:0030182 neuron differentiation 5/1157
## GO:0031076 embryonic camera-type eye development 3/1157
## GO:0055002 striated muscle cell development 3/1157
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 27/1157
## GO:0008217 regulation of blood pressure 4/1157
## GO:0005515 protein binding 248/1157
## BgRatio
## GO:0015245 fatty acid transmembrane transporter activity 6/18091
## GO:0001676 long-chain fatty acid metabolic process 7/18091
## GO:0004467 long-chain fatty acid-CoA ligase activity 7/18091
## GO:0015908 fatty acid transport 7/18091
## GO:0031957 very long-chain fatty acid-CoA ligase activity 7/18091
## GO:0006699 bile acid biosynthetic process 6/18091
## GO:0030168 platelet activation 7/18091
## GO:0047834 D-threo-aldose 1-dehydrogenase activity 15/18091
## GO:0021508 floor plate formation 6/18091
## GO:0030182 neuron differentiation 20/18091
## GO:0031076 embryonic camera-type eye development 7/18091
## GO:0055002 striated muscle cell development 7/18091
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 260/18091
## GO:0008217 regulation of blood pressure 14/18091
## GO:0005515 protein binding 3397/18091
## pvalue
## GO:0015245 fatty acid transmembrane transporter activity 6.029762e-06
## GO:0001676 long-chain fatty acid metabolic process 1.998571e-05
## GO:0004467 long-chain fatty acid-CoA ligase activity 1.998571e-05
## GO:0015908 fatty acid transport 1.998571e-05
## GO:0031957 very long-chain fatty acid-CoA ligase activity 1.998571e-05
## GO:0006699 bile acid biosynthetic process 2.249311e-04
## GO:0030168 platelet activation 4.981916e-04
## GO:0047834 D-threo-aldose 1-dehydrogenase activity 1.854733e-03
## GO:0021508 floor plate formation 4.507354e-03
## GO:0030182 neuron differentiation 7.330917e-03
## GO:0031076 embryonic camera-type eye development 7.514226e-03
## GO:0055002 striated muscle cell development 7.514226e-03
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 8.936766e-03
## GO:0008217 regulation of blood pressure 9.927827e-03
## GO:0005515 protein binding 1.007461e-02
## p.adjust
## GO:0015245 fatty acid transmembrane transporter activity 0.004308918
## GO:0001676 long-chain fatty acid metabolic process 0.004308918
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.004308918
## GO:0015908 fatty acid transport 0.004308918
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.004308918
## GO:0006699 bile acid biosynthetic process 0.040412619
## GO:0030168 platelet activation 0.076721507
## GO:0047834 D-threo-aldose 1-dehydrogenase activity 0.249925207
## GO:0021508 floor plate formation 0.539880880
## GO:0030182 neuron differentiation 0.675027996
## GO:0031076 embryonic camera-type eye development 0.675027996
## GO:0055002 striated muscle cell development 0.675027996
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.724028667
## GO:0008217 regulation of blood pressure 0.724028667
## GO:0005515 protein binding 0.724028667
## qvalue
## GO:0015245 fatty acid transmembrane transporter activity 0.00430429
## GO:0001676 long-chain fatty acid metabolic process 0.00430429
## GO:0004467 long-chain fatty acid-CoA ligase activity 0.00430429
## GO:0015908 fatty acid transport 0.00430429
## GO:0031957 very long-chain fatty acid-CoA ligase activity 0.00430429
## GO:0006699 bile acid biosynthetic process 0.04036921
## GO:0030168 platelet activation 0.07663910
## GO:0047834 D-threo-aldose 1-dehydrogenase activity 0.24965676
## GO:0021508 floor plate formation 0.53930099
## GO:0030182 neuron differentiation 0.67430294
## GO:0031076 embryonic camera-type eye development 0.67430294
## GO:0055002 striated muscle cell development 0.67430294
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.72325098
## GO:0008217 regulation of blood pressure 0.72325098
## GO:0005515 protein binding 0.72325098
## geneID
## GO:0015245 fatty acid transmembrane transporter activity ENSPREG00000015513/ENSPREG00000015526/ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0001676 long-chain fatty acid metabolic process ENSPREG00000015513/ENSPREG00000015526/ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0004467 long-chain fatty acid-CoA ligase activity ENSPREG00000015513/ENSPREG00000015526/ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0015908 fatty acid transport ENSPREG00000015513/ENSPREG00000015526/ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0031957 very long-chain fatty acid-CoA ligase activity ENSPREG00000015513/ENSPREG00000015526/ENSPREG00000018896/ENSPREG00000000320/ENSPREG00000015498
## GO:0006699 bile acid biosynthetic process ENSPREG00000015513/ENSPREG00000015526/ENSPREG00000018896/ENSPREG00000015498
## GO:0030168 platelet activation ENSPREG00000017046/ENSPREG00000014506/ENSPREG00000000530/ENSPREG00000002789
## GO:0047834 D-threo-aldose 1-dehydrogenase activity ENSPREG00000023124/ENSPREG00000017483/ENSPREG00000020382/ENSPREG00000000838/ENSPREG00000000605
## GO:0021508 floor plate formation ENSPREG00000006929/ENSPREG00000008962/ENSPREG00000004106
## GO:0030182 neuron differentiation ENSPREG00000009674/ENSPREG00000014608/ENSPREG00000019835/ENSPREG00000008962/ENSPREG00000004106
## GO:0031076 embryonic camera-type eye development ENSPREG00000008962/ENSPREG00000008541/ENSPREG00000004106
## GO:0055002 striated muscle cell development ENSPREG00000021266/ENSPREG00000008962/ENSPREG00000004106
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ENSPREG00000020203/ENSPREG00000012188/ENSPREG00000019823/ENSPREG00000011367/ENSPREG00000006929/ENSPREG00000007900/ENSPREG00000021725/ENSPREG00000020334/ENSPREG00000020340/ENSPREG00000006767/ENSPREG00000006315/ENSPREG00000013067/ENSPREG00000000568/ENSPREG00000002117/ENSPREG00000009674/ENSPREG00000002795/ENSPREG00000019795/ENSPREG00000013048/ENSPREG00000018023/ENSPREG00000010250/ENSPREG00000013766/ENSPREG00000012325/ENSPREG00000020178/ENSPREG00000001953/ENSPREG00000021717/ENSPREG00000006479/ENSPREG00000005993
## GO:0008217 regulation of blood pressure ENSPREG00000022019/ENSPREG00000003617/ENSPREG00000001051/ENSPREG00000001036
## GO:0005515 protein binding ENSPREG00000004594/ENSPREG00000011953/ENSPREG00000012251/ENSPREG00000005998/ENSPREG00000012853/ENSPREG00000018477/ENSPREG00000019319/ENSPREG00000021322/ENSPREG00000001335/ENSPREG00000015471/ENSPREG00000017867/ENSPREG00000005048/ENSPREG00000002585/ENSPREG00000012822/ENSPREG00000006498/ENSPREG00000006662/ENSPREG00000009060/ENSPREG00000022512/ENSPREG00000013014/ENSPREG00000006443/ENSPREG00000014506/ENSPREG00000017977/ENSPREG00000012897/ENSPREG00000020661/ENSPREG00000021152/ENSPREG00000001239/ENSPREG00000007778/ENSPREG00000017204/ENSPREG00000002248/ENSPREG00000019970/ENSPREG00000020137/ENSPREG00000001142/ENSPREG00000009748/ENSPREG00000008576/ENSPREG00000016967/ENSPREG00000009420/ENSPREG00000023130/ENSPREG00000021756/ENSPREG00000012860/ENSPREG00000019090/ENSPREG00000004636/ENSPREG00000005315/ENSPREG00000001734/ENSPREG00000018881/ENSPREG00000002194/ENSPREG00000013460/ENSPREG00000017713/ENSPREG00000004055/ENSPREG00000003556/ENSPREG00000014973/ENSPREG00000011222/ENSPREG00000018815/ENSPREG00000021689/ENSPREG00000013339/ENSPREG00000010675/ENSPREG00000015324/ENSPREG00000006112/ENSPREG00000000629/ENSPREG00000019123/ENSPREG00000003610/ENSPREG00000012466/ENSPREG00000020310/ENSPREG00000000313/ENSPREG00000002366/ENSPREG00000013162/ENSPREG00000018168/ENSPREG00000009555/ENSPREG00000010398/ENSPREG00000012620/ENSPREG00000022961/ENSPREG00000018867/ENSPREG00000004777/ENSPREG00000022326/ENSPREG00000022339/ENSPREG00000009493/ENSPREG00000022133/ENSPREG00000019390/ENSPREG00000022366/ENSPREG00000019952/ENSPREG00000021215/ENSPREG00000006634/ENSPREG00000007157/ENSPREG00000016525/ENSPREG00000011896/ENSPREG00000009469/ENSPREG00000003508/ENSPREG00000003290/ENSPREG00000011758/ENSPREG00000000685/ENSPREG00000010125/ENSPREG00000006987/ENSPREG00000021622/ENSPREG00000002476/ENSPREG00000014608/ENSPREG00000001983/ENSPREG00000011064/ENSPREG00000001980/ENSPREG00000008778/ENSPREG00000000341/ENSPREG00000015155/ENSPREG00000020009/ENSPREG00000010341/ENSPREG00000017454/ENSPREG00000012413/ENSPREG00000014822/ENSPREG00000004263/ENSPREG00000008123/ENSPREG00000021865/ENSPREG00000020140/ENSPREG00000022616/ENSPREG00000004029/ENSPREG00000005051/ENSPREG00000019340/ENSPREG00000009666/ENSPREG00000004300/ENSPREG00000015991/ENSPREG00000011159/ENSPREG00000000588/ENSPREG00000010064/ENSPREG00000017657/ENSPREG00000006440/ENSPREG00000004736/ENSPREG00000022808/ENSPREG00000005875/ENSPREG00000000164/ENSPREG00000015245/ENSPREG00000011352/ENSPREG00000007731/ENSPREG00000001779/ENSPREG00000000954/ENSPREG00000014507/ENSPREG00000022767/ENSPREG00000007331/ENSPREG00000021401/ENSPREG00000006028/ENSPREG00000011331/ENSPREG00000015478/ENSPREG00000004312/ENSPREG00000022344/ENSPREG00000009801/ENSPREG00000000217/ENSPREG00000022594/ENSPREG00000018440/ENSPREG00000011036/ENSPREG00000013046/ENSPREG00000018664/ENSPREG00000001224/ENSPREG00000005794/ENSPREG00000003283/ENSPREG00000020701/ENSPREG00000003868/ENSPREG00000016489/ENSPREG00000007238/ENSPREG00000021490/ENSPREG00000022867/ENSPREG00000000312/ENSPREG00000012615/ENSPREG00000012212/ENSPREG00000021620/ENSPREG00000016100/ENSPREG00000022506/ENSPREG00000014625/ENSPREG00000013019/ENSPREG00000018231/ENSPREG00000021017/ENSPREG00000002278/ENSPREG00000019089/ENSPREG00000021380/ENSPREG00000006212/ENSPREG00000012566/ENSPREG00000008369/ENSPREG00000006391/ENSPREG00000006354/ENSPREG00000004354/ENSPREG00000018987/ENSPREG00000017705/ENSPREG00000011094/ENSPREG00000007097/ENSPREG00000020039/ENSPREG00000008541/ENSPREG00000005556/ENSPREG00000020727/ENSPREG00000020745/ENSPREG00000011413/ENSPREG00000000237/ENSPREG00000019866/ENSPREG00000008775/ENSPREG00000008786/ENSPREG00000020410/ENSPREG00000007903/ENSPREG00000019244/ENSPREG00000011271/ENSPREG00000022182/ENSPREG00000005525/ENSPREG00000007539/ENSPREG00000019860/ENSPREG00000010850/ENSPREG00000003222/ENSPREG00000004106/ENSPREG00000020859/ENSPREG00000003143/ENSPREG00000019151/ENSPREG00000012782/ENSPREG00000003150/ENSPREG00000015244/ENSPREG00000008623/ENSPREG00000018444/ENSPREG00000000181/ENSPREG00000018381/ENSPREG00000001415/ENSPREG00000002035/ENSPREG00000010315/ENSPREG00000008224/ENSPREG00000012617/ENSPREG00000013138/ENSPREG00000016663/ENSPREG00000022200/ENSPREG00000000581/ENSPREG00000012133/ENSPREG00000018179/ENSPREG00000004374/ENSPREG00000000926/ENSPREG00000017328/ENSPREG00000022413/ENSPREG00000019505/ENSPREG00000020047/ENSPREG00000017608/ENSPREG00000023057/ENSPREG00000016255/ENSPREG00000012268/ENSPREG00000005211/ENSPREG00000019676/ENSPREG00000014417/ENSPREG00000002384/ENSPREG00000002405/ENSPREG00000007301/ENSPREG00000000191/ENSPREG00000020473/ENSPREG00000017329/ENSPREG00000010511/ENSPREG00000020089/ENSPREG00000004424/ENSPREG00000014739/ENSPREG00000011701/ENSPREG00000007082/ENSPREG00000018883/ENSPREG00000014833/ENSPREG00000010790
## Count
## GO:0015245 fatty acid transmembrane transporter activity 5
## GO:0001676 long-chain fatty acid metabolic process 5
## GO:0004467 long-chain fatty acid-CoA ligase activity 5
## GO:0015908 fatty acid transport 5
## GO:0031957 very long-chain fatty acid-CoA ligase activity 5
## GO:0006699 bile acid biosynthetic process 4
## GO:0030168 platelet activation 4
## GO:0047834 D-threo-aldose 1-dehydrogenase activity 5
## GO:0021508 floor plate formation 3
## GO:0030182 neuron differentiation 5
## GO:0031076 embryonic camera-type eye development 3
## GO:0055002 striated muscle cell development 3
## GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 27
## GO:0008217 regulation of blood pressure 4
## GO:0005515 protein binding 248For reproducibility
sessionInfo()## R version 4.1.1 (2021-08-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.3 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_AU.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_AU.UTF-8 LC_COLLATE=en_AU.UTF-8
## [5] LC_MONETARY=en_AU.UTF-8 LC_MESSAGES=en_AU.UTF-8
## [7] LC_PAPER=en_AU.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats4 parallel stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] eulerr_6.1.1 clusterProfiler_4.0.5
## [3] DESeq2_1.32.0 SummarizedExperiment_1.22.0
## [5] Biobase_2.52.0 MatrixGenerics_1.4.3
## [7] matrixStats_0.60.1 getDEE2_1.2.0
## [9] mitch_1.4.1 seqinr_4.2-8
## [11] gplots_3.1.1 methylKit_1.18.0
## [13] limma_3.48.3 GenomicRanges_1.44.0
## [15] GenomeInfoDb_1.28.4 IRanges_2.26.0
## [17] S4Vectors_0.30.0 BiocGenerics_0.38.0
## [19] RColorBrewer_1.1-2 dplyr_1.0.7
## [21] kableExtra_1.3.4 reshape2_1.4.4
## [23] R.utils_2.10.1 R.oo_1.24.0
## [25] R.methodsS3_1.8.1
##
## loaded via a namespace (and not attached):
## [1] utf8_1.2.2 tidyselect_1.1.1 RSQLite_2.2.8
## [4] AnnotationDbi_1.54.1 htmlwidgets_1.5.4 grid_4.1.1
## [7] BiocParallel_1.26.2 scatterpie_0.1.7 munsell_0.5.0
## [10] colorspace_2.0-2 GOSemSim_2.18.1 knitr_1.34
## [13] rstudioapi_0.13 fastseg_1.38.0 DOSE_3.18.2
## [16] bbmle_1.0.24 GenomeInfoDbData_1.2.6 polyclip_1.10-0
## [19] bit64_4.0.5 farver_2.1.0 downloader_0.4
## [22] coda_0.19-4 vctrs_0.3.8 treeio_1.16.2
## [25] generics_0.1.0 xfun_0.26 R6_2.5.1
## [28] graphlayouts_0.7.1 locfit_1.5-9.4 bitops_1.0-7
## [31] cachem_1.0.6 reshape_0.8.8 fgsea_1.18.0
## [34] gridGraphics_0.5-1 DelayedArray_0.18.0 assertthat_0.2.1
## [37] promises_1.2.0.1 BiocIO_1.2.0 scales_1.1.1
## [40] ggraph_2.0.5 enrichplot_1.12.2 beeswarm_0.4.0
## [43] gtable_0.3.0 tidygraph_1.2.0 rlang_0.4.11
## [46] genefilter_1.74.0 systemfonts_1.0.2 splines_4.1.1
## [49] rtracklayer_1.52.1 lazyeval_0.2.2 htm2txt_2.1.1
## [52] yaml_2.2.1 httpuv_1.6.3 qvalue_2.24.0
## [55] tools_4.1.1 ggplotify_0.1.0 ggplot2_3.3.5
## [58] ellipsis_0.3.2 jquerylib_0.1.4 Rcpp_1.0.7
## [61] plyr_1.8.6 zlibbioc_1.38.0 purrr_0.3.4
## [64] RCurl_1.98-1.4 viridis_0.6.1 cowplot_1.1.1
## [67] ggrepel_0.9.1 magrittr_2.0.1 data.table_1.14.0
## [70] DO.db_2.9 mvtnorm_1.1-2 patchwork_1.1.1
## [73] mime_0.11 evaluate_0.14 xtable_1.8-4
## [76] XML_3.99-0.7 emdbook_1.3.12 mclust_5.4.7
## [79] gridExtra_2.3 compiler_4.1.1 bdsmatrix_1.3-4
## [82] tibble_3.1.4 KernSmooth_2.23-20 crayon_1.4.1
## [85] shadowtext_0.0.8 htmltools_0.5.2 ggfun_0.0.3
## [88] later_1.3.0 tidyr_1.1.3 geneplotter_1.70.0
## [91] aplot_0.1.0 DBI_1.1.1 tweenr_1.0.2
## [94] MASS_7.3-54 Matrix_1.3-4 ade4_1.7-18
## [97] igraph_1.2.6 pkgconfig_2.0.3 GenomicAlignments_1.28.0
## [100] numDeriv_2016.8-1.1 xml2_1.3.2 ggtree_3.0.4
## [103] svglite_2.0.0 annotate_1.70.0 bslib_0.3.0
## [106] webshot_0.5.2 XVector_0.32.0 rvest_1.0.1
## [109] yulab.utils_0.0.2 stringr_1.4.0 digest_0.6.27
## [112] Biostrings_2.60.2 rmarkdown_2.11 fastmatch_1.1-3
## [115] tidytree_0.3.5 restfulr_0.0.13 shiny_1.6.0
## [118] Rsamtools_2.8.0 gtools_3.9.2 rjson_0.2.20
## [121] lifecycle_1.0.0 nlme_3.1-153 jsonlite_1.7.2
## [124] echarts4r_0.4.1 viridisLite_0.4.0 fansi_0.5.0
## [127] pillar_1.6.2 lattice_0.20-45 GGally_2.1.2
## [130] KEGGREST_1.32.0 fastmap_1.1.0 httr_1.4.2
## [133] survival_3.2-13 GO.db_3.13.0 glue_1.4.2
## [136] png_0.1-7 bit_4.0.4 ggforce_0.3.3
## [139] stringi_1.7.4 sass_0.4.0 blob_1.2.2
## [142] caTools_1.18.2 memoise_2.0.0 ape_5.5