date generated: 2020-07-11
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Here is the first few lines of the input profile.
## x
## 0610005C13Rik 0.5455811
## 0610009B22Rik -0.2758387
## 0610009E02Rik -0.1942335
## 0610009L18Rik 0.6285430
## 0610010F05Rik -1.9585193
## 0610012D04Rik -7.3024303
Here are some metrics about the input data profile:
Profile metrics | |
---|---|
num_genesets | 6 |
num_genes_in_profile | 16428 |
duplicated_genes_present | 0 |
num_profile_genes_in_sets | 426 |
num_profile_genes_not_in_sets | 16002 |
Here is a plot of the input profiles. Note the dynamic ranges.
Here is the contour plot of the profile including all detected genes.
Here are some metrics about the gene sets used: GMT file of genesets: atac.gmt
Gene sets metrics | |
---|---|
num_genesets | 6 |
num_genesets_excluded | 0 |
num_genesets_included | 6 |
Significance is calculated by -log10(p-value). All points shown are FDR<0.05.
Top N= 6 gene sets
set | setSize | pANOVA | s.dist | p.adjustANOVA |
---|---|---|---|---|
ATAC enhancer down | 141 | 4.10e-10 | -0.305 | 2.46e-09 |
ATAC tss up | 94 | 2.33e-09 | 0.357 | 7.00e-09 |
ATAC enhancer up | 88 | 7.36e-08 | 0.332 | 1.47e-07 |
ATAC tss down | 112 | 9.71e-07 | -0.268 | 1.46e-06 |
ATAC enhancer down with TEAD motif | 28 | 4.84e-02 | -0.216 | 5.81e-02 |
ATAC enhancer up with TEAD motif | 14 | 9.55e-02 | 0.257 | 9.55e-02 |
set | setSize | pANOVA | s.dist | p.adjustANOVA |
---|---|---|---|---|
ATAC enhancer down | 141 | 4.10e-10 | -0.305 | 2.46e-09 |
ATAC tss up | 94 | 2.33e-09 | 0.357 | 7.00e-09 |
ATAC enhancer up | 88 | 7.36e-08 | 0.332 | 1.47e-07 |
ATAC tss down | 112 | 9.71e-07 | -0.268 | 1.46e-06 |
ATAC enhancer down with TEAD motif | 28 | 4.84e-02 | -0.216 | 5.81e-02 |
ATAC enhancer up with TEAD motif | 14 | 9.55e-02 | 0.257 | 9.55e-02 |
ATAC enhancer down
2 | |
---|---|
set | ATAC enhancer down |
setSize | 141 |
pANOVA | 4.1e-10 |
s.dist | -0.305 |
p.adjustANOVA | 2.46e-09 |
Top enriched genes
GeneID | Gene Rank |
---|---|
Prima1 | -7903 |
Dkk3 | -7902 |
Fgf1 | -7869 |
Nr3c1 | -7849 |
Sgk1 | -7848 |
Slc2a3 | -7813 |
Fam160b1 | -7799 |
Mdga1 | -7754 |
Adrb2 | -7747 |
Crim1 | -7734 |
Dhrs3 | -7704 |
Pdlim5 | -7702 |
Gpt2 | -7636 |
Siah1a | -7569 |
Setbp1 | -7532 |
Adamts2 | -7507 |
Sorbs3 | -7495 |
Fkbp5 | -7491 |
Nphp4 | -7480 |
Idh2 | -7440 |
GeneID | Gene Rank |
---|---|
Prima1 | -7903 |
Dkk3 | -7902 |
Fgf1 | -7869 |
Nr3c1 | -7849 |
Sgk1 | -7848 |
Slc2a3 | -7813 |
Fam160b1 | -7799 |
Mdga1 | -7754 |
Adrb2 | -7747 |
Crim1 | -7734 |
Dhrs3 | -7704 |
Pdlim5 | -7702 |
Gpt2 | -7636 |
Siah1a | -7569 |
Setbp1 | -7532 |
Adamts2 | -7507 |
Sorbs3 | -7495 |
Fkbp5 | -7491 |
Nphp4 | -7480 |
Idh2 | -7440 |
Cachd1 | -7386 |
Man2a1 | -7350 |
Ankrd9 | -7320 |
Rbm20 | -7300 |
Sema7a | -7248 |
Arrdc2 | -7211 |
Glul | -7169 |
Mpped2 | -7076 |
Prkce | -6989 |
Fam78b | -6987 |
Mtus1 | -6945 |
Enho | -6847 |
Klf13 | -6817 |
0610038B21Rik | -6787 |
Ndufa6 | -6776 |
Ankrd26 | -6689 |
Creg1 | -6687 |
Zfp385b | -6646 |
Snta1 | -6630 |
Rhobtb1 | -6431 |
Nt5dc1 | -6388 |
Rgma | -6383 |
Max | -6319 |
Gbe1 | -6277 |
Trdn | -6270 |
Fzd7 | -6260 |
Ppp1r12b | -6258 |
Tbc1d1 | -6252 |
Zbtb16 | -6213 |
Sorl1 | -6136 |
Pgm2 | -6115 |
Cdc14a | -5998 |
Ptprm | -5918 |
Fam13c | -5865 |
Kremen1 | -5811 |
Ehd3 | -5785 |
Igsf3 | -5713 |
Plekha7 | -5624 |
Shroom3 | -5611 |
Gm826 | -5552 |
Pln | -5379 |
Dapk2 | -5257 |
1700123O20Rik | -4963 |
Fbxo3 | -4848 |
Klhl25 | -4749 |
Rpia | -4633 |
Synpo2 | -4532 |
Plbd2 | -4438 |
Cltc | -4154 |
2310015A10Rik | -4000 |
Farp2 | -3880 |
Eef2k | -3817 |
Afg3l2 | -3703 |
Ddx20 | -3608 |
Napb | -3432 |
Fyco1 | -3285 |
Itsn2 | -3149 |
Ticam1 | -2999 |
Ebf3 | -2965 |
Tpst2 | -2934 |
Trim32 | -2887 |
Prkca | -2874 |
Cish | -2749 |
Stard8 | -2260 |
Dnaic2 | -2249 |
Ccdc158 | -2161 |
Arid5b | -1908 |
Ggcx | -1713 |
Ankrd46 | -1617 |
Cd79b | -1475 |
Pde4dip | -1019 |
Rpl29 | -985 |
Msi2 | -953 |
Hopx | -769 |
Brpf3 | -749 |
Rell1 | -316 |
Lpin1 | 5 |
Aff1 | 390 |
Fntb | 520 |
Pmp22 | 718 |
Larp1 | 1117 |
Tmem229b | 1195 |
Eepd1 | 1250 |
Bicd2 | 1358 |
Npc1 | 1744 |
Atp13a1 | 2360 |
Fcer1g | 2509 |
Rcc2 | 2741 |
Agt | 2763 |
Slc36a1 | 2799 |
Slc41a3 | 2834 |
Tns1 | 2906 |
Srpk1 | 3349 |
Dnajc17 | 3724 |
Grin2b | 3847 |
Tmem123 | 4507 |
Abtb1 | 4925 |
Ap1s1 | 4989 |
Bcl6 | 5510 |
Bmp7 | 5560 |
Heg1 | 6182 |
Timp3 | 6221 |
Impa2 | 6238 |
Crip1 | 6522 |
Fbn1 | 6586 |
Fnbp1 | 6614 |
Rps6ka4 | 6720 |
Flnb | 6745 |
Ckap4 | 6772 |
Acvrl1 | 6799 |
Phf1 | 7069 |
Rab31 | 7168 |
Chaf1b | 7216 |
Cdc7 | 7456 |
Gnb4 | 7484 |
Thbs1 | 7600 |
Trerf1 | 8015 |
Ptprj | 8187 |
Litaf | 8272 |
Usp18 | 8324 |
Lair1 | 8499 |
ATAC tss up
3 | |
---|---|
set | ATAC tss up |
setSize | 94 |
pANOVA | 2.33e-09 |
s.dist | 0.357 |
p.adjustANOVA | 7e-09 |
Top enriched genes
GeneID | Gene Rank |
---|---|
Irf1 | 8514 |
Mx2 | 8430 |
Psmb9 | 8393 |
Pik3r5 | 8375 |
Irgm1 | 8366 |
B2m | 8156 |
Knstrn | 8131 |
Bid | 8078 |
Scamp5 | 8052 |
Rgs14 | 7955 |
Zc3hav1 | 7853 |
Icosl | 7652 |
Rps6ka1 | 7619 |
Chaf1a | 7602 |
Arap1 | 7584 |
Orai2 | 7577 |
Lasp1 | 7556 |
Map3k8 | 7555 |
Prex1 | 7451 |
Cdc6 | 7295 |
GeneID | Gene Rank |
---|---|
Irf1 | 8514 |
Mx2 | 8430 |
Psmb9 | 8393 |
Pik3r5 | 8375 |
Irgm1 | 8366 |
B2m | 8156 |
Knstrn | 8131 |
Bid | 8078 |
Scamp5 | 8052 |
Rgs14 | 7955 |
Zc3hav1 | 7853 |
Icosl | 7652 |
Rps6ka1 | 7619 |
Chaf1a | 7602 |
Arap1 | 7584 |
Orai2 | 7577 |
Lasp1 | 7556 |
Map3k8 | 7555 |
Prex1 | 7451 |
Cdc6 | 7295 |
Phldb1 | 7206 |
Zdhhc18 | 7072 |
Gramd2 | 7014 |
Tbx1 | 6981 |
Serpinb9 | 6970 |
Nxpe3 | 6939 |
Car9 | 6886 |
Src | 6850 |
Utrn | 6753 |
Cks2 | 6608 |
Rab3d | 6433 |
Capg | 6403 |
Arhgap23 | 6384 |
Id3 | 6370 |
Gstt2 | 6093 |
Nfix | 6087 |
Gps2 | 6040 |
Gm30771 | 6022 |
Wsb2 | 6010 |
Arhgef40 | 5910 |
Hmgb3 | 5700 |
Prtg | 5559 |
Rnpep | 5432 |
Herc3 | 5072 |
Lin9 | 4979 |
Vps9d1 | 4958 |
Myo15b | 4792 |
Frmd8 | 4678 |
Oscp1 | 4673 |
Ccdc69 | 4633 |
Aprt | 4394 |
Psd3 | 4332 |
Pus1 | 4295 |
Noc4l | 4199 |
Cd248 | 3716 |
Anp32a | 3140 |
Dus2 | 2884 |
Slc36a1 | 2799 |
Ramp1 | 2777 |
Fbxw4 | 2776 |
Sf3a3 | 2673 |
Gm24753 | 2285 |
Gls | 2152 |
Itga2b | 1988 |
Dpf1 | 1844 |
Esr1 | 1658 |
Cpeb1 | 855 |
Mrpl20 | 552 |
Calu | 176 |
Mtch1 | 82 |
Gars | -90 |
Msto1 | -349 |
Bckdk | -402 |
Neb | -595 |
Plgrkt | -669 |
Ppil2 | -792 |
Zfp384 | -1088 |
Erlin1 | -1255 |
Arl10 | -1636 |
Timm17a | -3226 |
Tmem70 | -3647 |
Ift81 | -3755 |
Sspn | -4441 |
Caml | -4538 |
Zfp286 | -4976 |
Matr3 | -5145 |
Ttc28 | -5150 |
Thnsl2 | -5228 |
Bcdin3d | -5872 |
Gm49258 | -6163 |
Ly6g6e | -6355 |
Zfp346 | -6856 |
Dmxl1 | -7114 |
9130230L23Rik | -7330 |
ATAC enhancer up
1 | |
---|---|
set | ATAC enhancer up |
setSize | 88 |
pANOVA | 7.36e-08 |
s.dist | 0.332 |
p.adjustANOVA | 1.47e-07 |
Top enriched genes
GeneID | Gene Rank |
---|---|
Card14 | 8425 |
Gsdmd | 8394 |
Prkch | 8376 |
Dhx58 | 8276 |
Batf | 8126 |
Cd83 | 7804 |
Olfm1 | 7779 |
Runx1 | 7737 |
Csrp1 | 7723 |
Arap1 | 7584 |
Rfc5 | 7452 |
Prex1 | 7451 |
Als2cl | 7333 |
Dusp5 | 7274 |
9130019P16Rik | 6947 |
Farp1 | 6710 |
Dusp10 | 6708 |
Arl5c | 6704 |
Capn1 | 6699 |
Srcin1 | 6652 |
GeneID | Gene Rank |
---|---|
Card14 | 8425 |
Gsdmd | 8394 |
Prkch | 8376 |
Dhx58 | 8276 |
Batf | 8126 |
Cd83 | 7804 |
Olfm1 | 7779 |
Runx1 | 7737 |
Csrp1 | 7723 |
Arap1 | 7584 |
Rfc5 | 7452 |
Prex1 | 7451 |
Als2cl | 7333 |
Dusp5 | 7274 |
9130019P16Rik | 6947 |
Farp1 | 6710 |
Dusp10 | 6708 |
Arl5c | 6704 |
Capn1 | 6699 |
Srcin1 | 6652 |
Cbx2 | 6495 |
Anxa4 | 6456 |
Begain | 6445 |
Spsb1 | 6437 |
Itga11 | 6423 |
Capg | 6403 |
Tmbim6 | 6245 |
Tpm2 | 6217 |
Ppp1r14c | 5985 |
Uchl1 | 5739 |
Lrrc49 | 5479 |
Fbln2 | 5257 |
Klf16 | 5231 |
Eif4g3 | 4884 |
Entpd7 | 4705 |
Ccdc69 | 4633 |
Dgkd | 4548 |
Gtf3c6 | 4515 |
Tmem123 | 4507 |
Rnf114 | 4088 |
Dffa | 4001 |
Bmf | 3930 |
Wnt9a | 3798 |
Ppargc1b | 3670 |
Sim2 | 3565 |
Sh2d4a | 3424 |
Ncoa3 | 3400 |
Cspg4 | 3313 |
Myh10 | 3309 |
Anp32a | 3140 |
Sfxn2 | 2994 |
Bhlhe41 | 2842 |
Ramp1 | 2777 |
Agt | 2763 |
Trim47 | 2761 |
Recql5 | 2605 |
Raph1 | 2570 |
Col4a2 | 2506 |
Apbb2 | 2486 |
Sufu | 2239 |
Ncor2 | 2179 |
Gls | 2152 |
Dnajb12 | 2121 |
Afap1l1 | 2017 |
Dpf1 | 1844 |
Xylt1 | 1510 |
Manbal | 517 |
Rnf103 | 373 |
Calu | 176 |
Svil | 139 |
Mtch1 | 82 |
Zfp36l1 | -450 |
Camk2a | -473 |
Zeb2 | -592 |
Ky | -1240 |
Pigv | -1484 |
Cables2 | -1879 |
Cstad | -2620 |
Tst | -2968 |
Trap1 | -4501 |
Jak1 | -5538 |
Col20a1 | -6149 |
I830077J02Rik | -6660 |
Gpc1 | -6707 |
Dnajb1 | -6836 |
Lpp | -7207 |
Slc30a2 | -7276 |
D430041D05Rik | -7701 |
ATAC tss down
4 | |
---|---|
set | ATAC tss down |
setSize | 112 |
pANOVA | 9.71e-07 |
s.dist | -0.268 |
p.adjustANOVA | 1.46e-06 |
Top enriched genes
GeneID | Gene Rank |
---|---|
Htra1 | -7906 |
Gm15337 | -7904 |
Cryab | -7892 |
8430426J06Rik | -7886 |
Gm48630 | -7879 |
Ell2 | -7839 |
Cntfr | -7833 |
Odf3l2 | -7821 |
Gm29323 | -7805 |
Eci2 | -7772 |
Tmem52 | -7766 |
Lrif1 | -7711 |
Cobll1 | -7700 |
Hsph1 | -7695 |
Napa | -7692 |
Slc35f5 | -7642 |
D830013O20Rik | -7610 |
9530020I12Rik | -7608 |
Gm11827 | -7575 |
Gm43672 | -7551 |
GeneID | Gene Rank |
---|---|
Htra1 | -7906 |
Gm15337 | -7904 |
Cryab | -7892 |
8430426J06Rik | -7886 |
Gm48630 | -7879 |
Ell2 | -7839 |
Cntfr | -7833 |
Odf3l2 | -7821 |
Gm29323 | -7805 |
Eci2 | -7772 |
Tmem52 | -7766 |
Lrif1 | -7711 |
Cobll1 | -7700 |
Hsph1 | -7695 |
Napa | -7692 |
Slc35f5 | -7642 |
D830013O20Rik | -7610 |
9530020I12Rik | -7608 |
Gm11827 | -7575 |
Gm43672 | -7551 |
Setbp1 | -7532 |
Tsc22d3 | -7527 |
Sorbs3 | -7495 |
6430571L13Rik | -7478 |
Sec14l1 | -7417 |
Chac1 | -7415 |
Jrkl | -7339 |
Ankrd9 | -7320 |
Glb1l2 | -7307 |
Gm15169 | -7267 |
Arrdc2 | -7211 |
Musk | -7173 |
Hspa8 | -7147 |
Klf13 | -6817 |
Stab2 | -6788 |
Zrsr1 | -6642 |
Pde4d | -6546 |
Rhobtb1 | -6431 |
Max | -6319 |
Tet1 | -6217 |
Bhlhe40 | -6098 |
Ndufs2 | -6017 |
Gm826 | -5552 |
Pde4a | -5350 |
Impact | -5346 |
Fbxo9 | -4954 |
Morf4l2 | -4803 |
Senp7 | -4782 |
Gm38074 | -4240 |
Shld1 | -4178 |
Pcdh9 | -3947 |
Clcn1 | -3501 |
Hdac9 | -3239 |
5430425K12Rik | -3103 |
Polr3b | -2896 |
Tkt | -2560 |
Ubr3 | -2393 |
Abt1 | -2342 |
2310001H17Rik | -2265 |
Nt5dc3 | -2100 |
Mir155hg | -2015 |
Bbs2 | -1983 |
Mpp7 | -1859 |
Gm37257 | -1815 |
Larp4b | -1434 |
Sephs1 | -1420 |
Pde4dip | -1019 |
Rab10os | -954 |
Pex7 | -693 |
Phc1 | -429 |
Tyw1 | -175 |
2410080I02Rik | 51 |
Hoxa10 | 345 |
Fam207a | 352 |
Gm32569 | 364 |
Xkr6 | 511 |
Haus7 | 730 |
Dnal1 | 758 |
Myom3 | 2218 |
Crebzf | 2745 |
Tns1 | 2906 |
Trrap | 3146 |
Rps23 | 3262 |
Slc24a3 | 3595 |
Car5b | 3645 |
Unkl | 3999 |
Gm10800 | 4026 |
Fxn | 4151 |
4930505A04Rik | 4170 |
Tacc2 | 4600 |
Pakap | 4639 |
Cux2 | 4650 |
Ctnna2 | 4719 |
Gm10801 | 4774 |
Awat2 | 4955 |
Mta1 | 5050 |
Epha3 | 5079 |
Gm5444 | 5296 |
Eda2r | 5650 |
Gm21738 | 5707 |
Kcnip1 | 5753 |
Exo5 | 6109 |
Gm11872 | 6174 |
Gabre | 6468 |
Mt2 | 6626 |
Ppp2r3d | 6833 |
Plekhg1 | 6996 |
Grip2 | 7263 |
Fam189a1 | 7465 |
Frmd4b | 7570 |
Tns3 | 7876 |
Litaf | 8272 |
ATAC enhancer down with TEAD motif
5 | |
---|---|
set | ATAC enhancer down with TEAD motif |
setSize | 28 |
pANOVA | 0.0484 |
s.dist | -0.216 |
p.adjustANOVA | 0.0581 |
Top enriched genes
GeneID | Gene Rank |
---|---|
Dkk3 | -7902 |
Gm973 | -7858 |
Mdga1 | -7754 |
Adrb2 | -7747 |
Idh2 | -7440 |
Cachd1 | -7386 |
Ghr | -7193 |
Klf13 | -6817 |
Fzd7 | -6260 |
AW549877 | -6216 |
Igsf3 | -5713 |
Zfyve19 | -4484 |
Napb | -3432 |
Tpst2 | -2934 |
Hopx | -769 |
Rell1 | -316 |
Lpin1 | 5 |
Itgb5 | 374 |
Vps18 | 778 |
Ilf3 | 2169 |
GeneID | Gene Rank |
---|---|
Dkk3 | -7902 |
Gm973 | -7858 |
Mdga1 | -7754 |
Adrb2 | -7747 |
Idh2 | -7440 |
Cachd1 | -7386 |
Ghr | -7193 |
Klf13 | -6817 |
Fzd7 | -6260 |
AW549877 | -6216 |
Igsf3 | -5713 |
Zfyve19 | -4484 |
Napb | -3432 |
Tpst2 | -2934 |
Hopx | -769 |
Rell1 | -316 |
Lpin1 | 5 |
Itgb5 | 374 |
Vps18 | 778 |
Ilf3 | 2169 |
Tns1 | 2906 |
Dnajc17 | 3724 |
Slc44a2 | 4542 |
Trim41 | 5975 |
Heg1 | 6182 |
Rps6ka4 | 6720 |
Thbs1 | 7600 |
Irgm1 | 8366 |
ATAC enhancer up with TEAD motif
6 | |
---|---|
set | ATAC enhancer up with TEAD motif |
setSize | 14 |
pANOVA | 0.0955 |
s.dist | 0.257 |
p.adjustANOVA | 0.0955 |
Top enriched genes
GeneID | Gene Rank |
---|---|
Batf | 8126 |
Ablim3 | 6919 |
Kcnq2 | 5946 |
Itgb4 | 5941 |
Eef1a2 | 5696 |
Bmf | 3930 |
Wnt9a | 3798 |
Galk1 | 3692 |
Raph1 | 2570 |
Ncor2 | 2179 |
Afap1l1 | 2017 |
Trap1 | -4501 |
Col20a1 | -6149 |
Chrna4 | -6294 |
GeneID | Gene Rank |
---|---|
Batf | 8126 |
Ablim3 | 6919 |
Kcnq2 | 5946 |
Itgb4 | 5941 |
Eef1a2 | 5696 |
Bmf | 3930 |
Wnt9a | 3798 |
Galk1 | 3692 |
Raph1 | 2570 |
Ncor2 | 2179 |
Afap1l1 | 2017 |
Trap1 | -4501 |
Col20a1 | -6149 |
Chrna4 | -6294 |
Here is the session info with all the versions of packages used.
sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0
## [3] beeswarm_0.2.3 gtools_3.8.2
## [5] echarts4r_0.3.2 mitch_1.0.6
## [7] MASS_7.3-51.6 fgsea_1.14.0
## [9] gplots_3.0.3 DESeq2_1.28.1
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0
## [13] matrixStats_0.56.0 Biobase_2.48.0
## [15] GenomicRanges_1.40.0 GenomeInfoDb_1.24.2
## [17] IRanges_2.22.2 S4Vectors_0.26.1
## [19] BiocGenerics_0.34.0 reshape2_1.4.4
## [21] forcats_0.5.0 stringr_1.4.0
## [23] dplyr_1.0.0 purrr_0.3.4
## [25] readr_1.3.1 tidyr_1.1.0
## [27] tibble_3.0.1 ggplot2_3.3.2
## [29] tidyverse_1.3.0
##
## loaded via a namespace (and not attached):
## [1] colorspace_1.4-1 ellipsis_0.3.1 rprojroot_1.3-2
## [4] XVector_0.28.0 fs_1.4.2 rstudioapi_0.11
## [7] bit64_0.9-7 AnnotationDbi_1.50.1 fansi_0.4.1
## [10] lubridate_1.7.9 xml2_1.3.2 splines_4.0.2
## [13] geneplotter_1.66.0 knitr_1.29 jsonlite_1.7.0
## [16] broom_0.5.6 annotate_1.66.0 dbplyr_1.4.4
## [19] shiny_1.5.0 compiler_4.0.2 httr_1.4.1
## [22] backports_1.1.8 assertthat_0.2.1 Matrix_1.2-18
## [25] fastmap_1.0.1 cli_2.0.2 later_1.1.0.1
## [28] htmltools_0.5.0 tools_4.0.2 gtable_0.3.0
## [31] glue_1.4.1 GenomeInfoDbData_1.2.3 fastmatch_1.1-0
## [34] Rcpp_1.0.4.6 cellranger_1.1.0 vctrs_0.3.1
## [37] gdata_2.18.0 nlme_3.1-148 xfun_0.15
## [40] testthat_2.3.2 rvest_0.3.5 mime_0.9
## [43] lifecycle_0.2.0 XML_3.99-0.3 zlibbioc_1.34.0
## [46] scales_1.1.1 hms_0.5.3 promises_1.1.1
## [49] RColorBrewer_1.1-2 yaml_2.2.1 memoise_1.1.0
## [52] gridExtra_2.3 reshape_0.8.8 stringi_1.4.6
## [55] RSQLite_2.2.0 highr_0.8 genefilter_1.70.0
## [58] desc_1.2.0 caTools_1.18.0 BiocParallel_1.22.0
## [61] rlang_0.4.6 pkgconfig_2.0.3 bitops_1.0-6
## [64] evaluate_0.14 lattice_0.20-41 htmlwidgets_1.5.1
## [67] bit_1.1-15.2 tidyselect_1.1.0 plyr_1.8.6
## [70] magrittr_1.5 R6_2.4.1 generics_0.0.2
## [73] DBI_1.1.0 pillar_1.4.4 haven_2.3.1
## [76] withr_2.2.0 survival_3.2-3 RCurl_1.98-1.2
## [79] modelr_0.1.8 crayon_1.3.4 KernSmooth_2.23-17
## [82] rmarkdown_2.3 locfit_1.5-9.4 grid_4.0.2
## [85] readxl_1.3.1 data.table_1.12.8 blob_1.2.1
## [88] reprex_0.3.0 digest_0.6.25 pbmcapply_1.5.0
## [91] xtable_1.8-4 httpuv_1.5.4 munsell_0.5.0
END of report