Mitch Report

date generated: 2020-07-11

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## A1BG     0.5545204
## A3GALT2  0.7229446
## A4GALT   5.5067919
## AAAS     1.6105560
## AACS     1.1463724
## AAED1   -0.0993333

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2400
num_genes_in_profile	13056
duplicated_genes_present	0
num_profile_genes_in_sets	7375
num_profile_genes_not_in_sets	5681

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1072
num_genesets_included	1328

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
FCGR activation	11	3.45e-07	0.887	1.09e-05
PD-1 signaling	13	8.38e-07	0.789	2.47e-05
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	49	2.04e-20	0.764	9.05e-18
Interleukin-10 signaling	26	1.39e-10	0.727	8.01e-09
Phosphorylation of CD3 and TCR zeta chains	12	1.65e-05	0.718	3.43e-04
Interferon alpha/beta signaling	42	2.85e-15	0.704	4.20e-13
Signal regulatory protein family interactions	13	2.74e-05	0.672	5.19e-04
Generation of second messenger molecules	24	4.35e-08	0.646	1.60e-06
Other interleukin signaling	18	3.59e-06	0.631	9.53e-05
Interleukin-2 signaling	10	7.00e-04	0.619	7.75e-03
Folding of actin by CCT/TriC	10	8.94e-04	-0.607	9.43e-03
Crosslinking of collagen fibrils	10	1.98e-03	0.565	1.73e-02
BBSome-mediated cargo-targeting to cilium	20	1.38e-05	-0.562	2.95e-04
Dectin-2 family	10	2.14e-03	0.561	1.85e-02
Citric acid cycle (TCA cycle)	21	9.19e-06	-0.559	2.10e-04
PECAM1 interactions	11	1.38e-03	0.557	1.34e-02
Regulation of IFNA signaling	12	9.33e-04	0.552	9.68e-03
Assembly of collagen fibrils and other multimeric structures	49	7.73e-11	0.537	4.93e-09
Inflammasomes	19	6.24e-05	0.531	1.06e-03
Collagen chain trimerization	40	8.33e-09	0.526	3.46e-07
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	1.12e-03	0.522	1.13e-02
Interferon gamma signaling	61	7.18e-12	0.507	6.81e-10
Glyoxylate metabolism and glycine degradation	23	5.37e-05	-0.487	9.39e-04
Antimicrobial peptides	11	5.75e-03	0.481	4.10e-02
NCAM1 interactions	30	7.15e-06	0.474	1.73e-04
DAP12 interactions	28	1.46e-05	0.473	3.07e-04
The NLRP3 inflammasome	14	2.66e-03	0.464	2.19e-02
Interleukin-20 family signaling	14	2.78e-03	0.462	2.27e-02
Chondroitin sulfate biosynthesis	16	1.49e-03	0.459	1.38e-02
Regulation of KIT signaling	16	1.50e-03	0.458	1.38e-02
RIPK1-mediated regulated necrosis	14	3.02e-03	0.458	2.36e-02
Regulated Necrosis	14	3.02e-03	0.458	2.36e-02
Cell recruitment (pro-inflammatory response)	19	5.61e-04	0.457	6.32e-03
Purinergic signaling in leishmaniasis infection	19	5.61e-04	0.457	6.32e-03
N-Glycan antennae elongation	14	3.24e-03	0.454	2.50e-02
ATF6 (ATF6-alpha) activates chaperone genes	10	1.32e-02	-0.452	7.57e-02
Attenuation phase	21	3.69e-04	-0.449	4.95e-03
Nucleotide-like (purinergic) receptors	11	1.04e-02	0.446	6.40e-02
Chemokine receptors bind chemokines	22	2.94e-04	0.446	4.03e-03
Unwinding of DNA	12	7.93e-03	0.443	5.19e-02
GPVI-mediated activation cascade	30	3.23e-05	0.439	6.03e-04
Condensation of Prometaphase Chromosomes	11	1.21e-02	0.437	7.09e-02
DAP12 signaling	26	1.22e-04	0.435	1.95e-03
Methylation	11	1.30e-02	-0.433	7.48e-02
Defects in vitamin and cofactor metabolism	19	1.32e-03	-0.426	1.30e-02
Initial triggering of complement	14	5.96e-03	0.424	4.21e-02
Transcriptional regulation of granulopoiesis	27	1.66e-04	0.419	2.51e-03
Defects in cobalamin (B12) metabolism	11	1.67e-02	-0.417	8.82e-02
TNFR1-induced proapoptotic signaling	13	9.33e-03	0.416	5.87e-02
Activation of Matrix Metalloproteinases	13	9.70e-03	0.414	6.05e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
FCGR activation	11	3.45e-07	0.887000	1.09e-05
PD-1 signaling	13	8.38e-07	0.789000	2.47e-05
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	49	2.04e-20	0.764000	9.05e-18
Interleukin-10 signaling	26	1.39e-10	0.727000	8.01e-09
Phosphorylation of CD3 and TCR zeta chains	12	1.65e-05	0.718000	3.43e-04
Interferon alpha/beta signaling	42	2.85e-15	0.704000	4.20e-13
Signal regulatory protein family interactions	13	2.74e-05	0.672000	5.19e-04
Generation of second messenger molecules	24	4.35e-08	0.646000	1.60e-06
Other interleukin signaling	18	3.59e-06	0.631000	9.53e-05
Interleukin-2 signaling	10	7.00e-04	0.619000	7.75e-03
Folding of actin by CCT/TriC	10	8.94e-04	-0.607000	9.43e-03
Crosslinking of collagen fibrils	10	1.98e-03	0.565000	1.73e-02
BBSome-mediated cargo-targeting to cilium	20	1.38e-05	-0.562000	2.95e-04
Dectin-2 family	10	2.14e-03	0.561000	1.85e-02
Citric acid cycle (TCA cycle)	21	9.19e-06	-0.559000	2.10e-04
PECAM1 interactions	11	1.38e-03	0.557000	1.34e-02
Regulation of IFNA signaling	12	9.33e-04	0.552000	9.68e-03
Assembly of collagen fibrils and other multimeric structures	49	7.73e-11	0.537000	4.93e-09
Inflammasomes	19	6.24e-05	0.531000	1.06e-03
Collagen chain trimerization	40	8.33e-09	0.526000	3.46e-07
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	1.12e-03	0.522000	1.13e-02
Interferon gamma signaling	61	7.18e-12	0.507000	6.81e-10
Glyoxylate metabolism and glycine degradation	23	5.37e-05	-0.487000	9.39e-04
Antimicrobial peptides	11	5.75e-03	0.481000	4.10e-02
NCAM1 interactions	30	7.15e-06	0.474000	1.73e-04
DAP12 interactions	28	1.46e-05	0.473000	3.07e-04
The NLRP3 inflammasome	14	2.66e-03	0.464000	2.19e-02
Interleukin-20 family signaling	14	2.78e-03	0.462000	2.27e-02
Chondroitin sulfate biosynthesis	16	1.49e-03	0.459000	1.38e-02
Regulation of KIT signaling	16	1.50e-03	0.458000	1.38e-02
RIPK1-mediated regulated necrosis	14	3.02e-03	0.458000	2.36e-02
Regulated Necrosis	14	3.02e-03	0.458000	2.36e-02
Cell recruitment (pro-inflammatory response)	19	5.61e-04	0.457000	6.32e-03
Purinergic signaling in leishmaniasis infection	19	5.61e-04	0.457000	6.32e-03
N-Glycan antennae elongation	14	3.24e-03	0.454000	2.50e-02
ATF6 (ATF6-alpha) activates chaperone genes	10	1.32e-02	-0.452000	7.57e-02
Attenuation phase	21	3.69e-04	-0.449000	4.95e-03
Nucleotide-like (purinergic) receptors	11	1.04e-02	0.446000	6.40e-02
Chemokine receptors bind chemokines	22	2.94e-04	0.446000	4.03e-03
Unwinding of DNA	12	7.93e-03	0.443000	5.19e-02
GPVI-mediated activation cascade	30	3.23e-05	0.439000	6.03e-04
Condensation of Prometaphase Chromosomes	11	1.21e-02	0.437000	7.09e-02
DAP12 signaling	26	1.22e-04	0.435000	1.95e-03
Methylation	11	1.30e-02	-0.433000	7.48e-02
Defects in vitamin and cofactor metabolism	19	1.32e-03	-0.426000	1.30e-02
Initial triggering of complement	14	5.96e-03	0.424000	4.21e-02
Transcriptional regulation of granulopoiesis	27	1.66e-04	0.419000	2.51e-03
Defects in cobalamin (B12) metabolism	11	1.67e-02	-0.417000	8.82e-02
TNFR1-induced proapoptotic signaling	13	9.33e-03	0.416000	5.87e-02
Activation of Matrix Metalloproteinases	13	9.70e-03	0.414000	6.05e-02
Integrin cell surface interactions	53	1.88e-07	0.414000	6.39e-06
FOXO-mediated transcription of cell death genes	14	7.39e-03	-0.414000	4.88e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	48	7.48e-07	-0.413000	2.26e-05
Kinesins	38	1.07e-05	0.413000	2.37e-04
Scavenging by Class A Receptors	13	1.06e-02	0.409000	6.53e-02
CASP8 activity is inhibited	10	2.58e-02	0.407000	1.15e-01
Dimerization of procaspase-8	10	2.58e-02	0.407000	1.15e-01
Regulation by c-FLIP	10	2.58e-02	0.407000	1.15e-01
Interleukin-2 family signaling	33	6.69e-05	0.401000	1.13e-03
Surfactant metabolism	13	1.27e-02	0.399000	7.40e-02
ATF6 (ATF6-alpha) activates chaperones	12	1.67e-02	-0.399000	8.82e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	2.61e-04	0.399000	3.61e-03
Synthesis of glycosylphosphatidylinositol (GPI)	17	4.53e-03	-0.398000	3.40e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	3.05e-02	0.395000	1.29e-01
Respiratory electron transport	92	6.12e-11	-0.395000	4.28e-09
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	97	1.94e-11	-0.395000	1.61e-09
Interleukin-4 and Interleukin-13 signaling	79	1.49e-09	0.394000	7.90e-08
The citric acid (TCA) cycle and respiratory electron transport	141	9.42e-16	-0.392000	1.56e-13
FCERI mediated Ca+2 mobilization	27	4.55e-04	0.390000	5.50e-03
Acetylcholine regulates insulin secretion	10	3.31e-02	0.389000	1.34e-01
Trafficking and processing of endosomal TLR	11	2.60e-02	0.388000	1.15e-01
Amine ligand-binding receptors	13	1.58e-02	0.387000	8.54e-02
Regulation of innate immune responses to cytosolic DNA	11	2.70e-02	0.385000	1.18e-01
Laminin interactions	23	1.49e-03	0.383000	1.38e-02
Regulation of necroptotic cell death	12	2.18e-02	0.382000	1.04e-01
Class A/1 (Rhodopsin-like receptors)	116	1.72e-12	0.380000	1.91e-10
Glycogen synthesis	13	1.88e-02	-0.377000	9.51e-02
Caspase activation via Death Receptors in the presence of ligand	13	1.89e-02	0.376000	9.52e-02
Termination of O-glycan biosynthesis	11	3.14e-02	0.375000	1.31e-01
TNFs bind their physiological receptors	14	1.52e-02	0.375000	8.33e-02
Mitochondrial translation termination	81	6.37e-09	-0.373000	3.02e-07
Class I peroxisomal membrane protein import	19	4.84e-03	-0.373000	3.57e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR)	35	1.40e-04	-0.372000	2.21e-03
Mitochondrial translation initiation	81	7.99e-09	-0.371000	3.42e-07
Collagen formation	77	1.87e-08	0.371000	7.31e-07
Cargo trafficking to the periciliary membrane	45	1.78e-05	-0.370000	3.59e-04
Mitochondrial translation	87	2.84e-09	-0.369000	1.40e-07
Polo-like kinase mediated events	15	1.55e-02	0.361000	8.42e-02
Regulation of FOXO transcriptional activity by acetylation	10	4.90e-02	-0.360000	1.67e-01
Mitochondrial translation elongation	81	2.40e-08	-0.359000	9.11e-07
Cobalamin (Cbl, vitamin B12) transport and metabolism	12	3.14e-02	-0.359000	1.31e-01
Downregulation of ERBB2:ERBB3 signaling	11	3.94e-02	0.359000	1.46e-01
Keratan sulfate biosynthesis	20	5.48e-03	0.359000	3.94e-02
Anti-inflammatory response favouring Leishmania parasite infection	88	7.84e-09	0.356000	3.42e-07
Leishmania parasite growth and survival	88	7.84e-09	0.356000	3.42e-07
Complex I biogenesis	52	1.03e-05	-0.354000	2.33e-04
Collagen biosynthesis and modifying enzymes	60	2.45e-06	0.352000	6.91e-05
Mitochondrial protein import	56	5.56e-06	-0.351000	1.45e-04
Regulation of Complement cascade	28	1.44e-03	0.348000	1.38e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	12	3.79e-02	0.346000	1.45e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	12	3.79e-02	0.346000	1.45e-01
DNA strand elongation	32	7.09e-04	0.346000	7.78e-03
FCGR3A-mediated phagocytosis	57	6.82e-06	0.345000	1.68e-04
Leishmania phagocytosis	57	6.82e-06	0.345000	1.68e-04
Parasite infection	57	6.82e-06	0.345000	1.68e-04
HSF1-dependent transactivation	31	9.21e-04	-0.344000	9.63e-03
Non-integrin membrane-ECM interactions	41	1.41e-04	0.344000	2.21e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	2.98e-03	0.343000	2.36e-02
FCGR3A-mediated IL10 synthesis	35	5.22e-04	0.339000	6.08e-03
Interferon Signaling	140	5.52e-12	0.338000	5.64e-10
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	6.66e-02	0.335000	2.00e-01
alpha-linolenic acid (ALA) metabolism	10	6.66e-02	0.335000	2.00e-01
Branched-chain amino acid catabolism	21	8.20e-03	-0.333000	5.31e-02
Degradation of cysteine and homocysteine	13	3.75e-02	-0.333000	1.44e-01
Formation of Fibrin Clot (Clotting Cascade)	16	2.11e-02	0.333000	1.01e-01
cGMP effects	14	3.21e-02	0.331000	1.32e-01
Elastic fibre formation	38	4.24e-04	0.331000	5.37e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	5.79e-02	0.330000	1.92e-01
LGI-ADAM interactions	10	7.10e-02	0.330000	2.07e-01
Interleukin-37 signaling	18	1.61e-02	0.328000	8.65e-02
Pre-NOTCH Processing in Golgi	16	2.36e-02	0.327000	1.09e-01
Extracellular matrix organization	227	3.07e-17	0.326000	8.15e-15
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.34e-02	-0.323000	1.98e-01
Keratinization	14	3.63e-02	0.323000	1.42e-01
Collagen degradation	26	4.55e-03	0.322000	3.40e-02
Plasma lipoprotein clearance	24	6.65e-03	0.320000	4.55e-02
Mitochondrial Fatty Acid Beta-Oxidation	33	1.47e-03	-0.320000	1.38e-02
tRNA processing in the mitochondrion	13	4.58e-02	0.320000	1.63e-01
Intraflagellar transport	38	7.38e-04	-0.317000	7.91e-03
Syndecan interactions	20	1.44e-02	0.316000	7.99e-02
Nitric oxide stimulates guanylate cyclase	20	1.46e-02	0.316000	8.05e-02
G0 and Early G1	25	6.61e-03	0.314000	4.55e-02
Interleukin receptor SHC signaling	20	1.52e-02	0.314000	8.33e-02
Endogenous sterols	18	2.15e-02	0.313000	1.03e-01
Sulfur amino acid metabolism	22	1.11e-02	-0.313000	6.66e-02
Synthesis of pyrophosphates in the cytosol	10	8.72e-02	-0.312000	2.34e-01
Interleukin-35 Signalling	11	7.31e-02	0.312000	2.12e-01
Processing of SMDT1	14	4.39e-02	-0.311000	1.58e-01
HIV Transcription Initiation	44	3.88e-04	-0.309000	4.95e-03
RNA Polymerase II HIV Promoter Escape	44	3.88e-04	-0.309000	4.95e-03
RNA Polymerase II Promoter Escape	44	3.88e-04	-0.309000	4.95e-03
RNA Polymerase II Transcription Initiation	44	3.88e-04	-0.309000	4.95e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance	44	3.88e-04	-0.309000	4.95e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	44	3.88e-04	-0.309000	4.95e-03
Integrin signaling	24	8.80e-03	0.309000	5.59e-02
DARPP-32 events	21	1.43e-02	-0.309000	7.99e-02
Formation of the cornified envelope	11	7.64e-02	0.309000	2.17e-01
Intrinsic Pathway of Fibrin Clot Formation	10	9.23e-02	0.307000	2.44e-01
G1/S-Specific Transcription	26	6.70e-03	0.307000	4.56e-02
ECM proteoglycans	44	4.36e-04	0.307000	5.46e-03
Leishmania infection	164	1.41e-11	0.306000	1.25e-09
Caspase activation via extrinsic apoptotic signalling pathway	23	1.15e-02	0.305000	6.76e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.99e-02	0.304000	1.27e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.99e-02	0.304000	1.27e-01
TICAM1-dependent activation of IRF3/IRF7	10	9.62e-02	0.304000	2.50e-01
AMER1 mutants destabilize the destruction complex	13	5.85e-02	-0.303000	1.92e-01
APC truncation mutants have impaired AXIN binding	13	5.85e-02	-0.303000	1.92e-01
AXIN missense mutants destabilize the destruction complex	13	5.85e-02	-0.303000	1.92e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	13	5.85e-02	-0.303000	1.92e-01
Truncations of AMER1 destabilize the destruction complex	13	5.85e-02	-0.303000	1.92e-01
truncated APC mutants destabilize the destruction complex	13	5.85e-02	-0.303000	1.92e-01
MET activates PTK2 signaling	18	2.62e-02	0.303000	1.16e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	1.64e-02	0.303000	8.76e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	3.65e-02	0.302000	1.42e-01
Degradation of the extracellular matrix	73	8.26e-06	0.302000	1.96e-04
Leading Strand Synthesis	14	5.07e-02	0.302000	1.72e-01
Polymerase switching	14	5.07e-02	0.302000	1.72e-01
Processing of Intronless Pre-mRNAs	17	3.14e-02	-0.302000	1.31e-01
Regulation of HSF1-mediated heat shock response	67	2.00e-05	-0.301000	3.91e-04
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	6.00e-02	0.301000	1.95e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	7.53e-02	0.297000	2.16e-01
Vitamin B5 (pantothenate) metabolism	15	4.69e-02	-0.296000	1.65e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	37	1.85e-03	0.296000	1.64e-02
RORA activates gene expression	17	3.52e-02	-0.295000	1.39e-01
Keratan sulfate/keratin metabolism	25	1.07e-02	0.295000	6.55e-02
Mitochondrial iron-sulfur cluster biogenesis	12	7.70e-02	-0.295000	2.18e-01
Synthesis, secretion, and deacylation of Ghrelin	13	6.59e-02	-0.295000	2.00e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	47	4.79e-04	0.295000	5.68e-03
Energy dependent regulation of mTOR by LKB1-AMPK	29	6.19e-03	-0.294000	4.33e-02
Costimulation by the CD28 family	57	1.49e-04	0.291000	2.27e-03
Glycogen storage diseases	12	8.19e-02	-0.290000	2.25e-01
Defective B3GAT3 causes JDSSDHD	17	3.98e-02	0.288000	1.47e-01
GPCR ligand binding	175	5.82e-11	0.288000	4.28e-09
Lagging Strand Synthesis	20	2.62e-02	0.287000	1.16e-01
Signaling by PDGF	50	4.66e-04	0.286000	5.57e-03
Signaling by WNT in cancer	29	8.12e-03	-0.284000	5.28e-02
Misspliced GSK3beta mutants stabilize beta-catenin	14	6.65e-02	-0.283000	2.00e-01
S33 mutants of beta-catenin aren't phosphorylated	14	6.65e-02	-0.283000	2.00e-01
S37 mutants of beta-catenin aren't phosphorylated	14	6.65e-02	-0.283000	2.00e-01
S45 mutants of beta-catenin aren't phosphorylated	14	6.65e-02	-0.283000	2.00e-01
T41 mutants of beta-catenin aren't phosphorylated	14	6.65e-02	-0.283000	2.00e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	14	6.65e-02	-0.283000	2.00e-01
Regulation of TNFR1 signaling	27	1.11e-02	0.283000	6.66e-02
CD28 dependent Vav1 pathway	12	9.03e-02	0.282000	2.41e-01
TRP channels	15	5.89e-02	0.282000	1.93e-01
Interleukin-27 signaling	10	1.24e-01	0.281000	2.94e-01
Regulation of actin dynamics for phagocytic cup formation	59	1.91e-04	0.281000	2.73e-03
Mitochondrial calcium ion transport	20	3.02e-02	-0.280000	1.28e-01
RA biosynthesis pathway	15	6.16e-02	-0.279000	1.98e-01
Biosynthesis of specialized proresolving mediators (SPMs)	12	9.49e-02	0.278000	2.49e-01
RHO GTPases Activate NADPH Oxidases	20	3.18e-02	0.277000	1.32e-01
Signaling by SCF-KIT	40	2.47e-03	0.277000	2.07e-02
Fcgamma receptor (FCGR) dependent phagocytosis	82	1.79e-05	0.274000	3.59e-04
Peroxisomal protein import	50	8.02e-04	-0.274000	8.52e-03
VxPx cargo-targeting to cilium	18	4.44e-02	-0.274000	1.60e-01
Binding and Uptake of Ligands by Scavenger Receptors	29	1.08e-02	0.274000	6.57e-02
AKT phosphorylates targets in the cytosol	14	7.67e-02	0.273000	2.18e-01
Biotin transport and metabolism	11	1.17e-01	-0.273000	2.86e-01
Activation of the pre-replicative complex	31	8.56e-03	0.273000	5.49e-02
Circadian Clock	63	1.88e-04	-0.272000	2.72e-03
Pyruvate metabolism	25	1.86e-02	-0.272000	9.45e-02
Prolactin receptor signaling	11	1.18e-01	-0.272000	2.88e-01
ROS and RNS production in phagocytes	28	1.28e-02	0.272000	7.44e-02
Complement cascade	33	7.01e-03	0.271000	4.75e-02
Platelet Aggregation (Plug Formation)	26	1.70e-02	0.271000	8.89e-02
The role of Nef in HIV-1 replication and disease pathogenesis	25	1.93e-02	0.270000	9.59e-02
TRAF3-dependent IRF activation pathway	13	9.17e-02	0.270000	2.44e-01
Factors involved in megakaryocyte development and platelet production	103	2.35e-06	0.270000	6.77e-05
Formation of TC-NER Pre-Incision Complex	50	1.00e-03	-0.269000	1.02e-02
Activation of BAD and translocation to mitochondria	14	8.29e-02	0.268000	2.26e-01
EPH-ephrin mediated repulsion of cells	41	3.11e-03	0.267000	2.41e-02
VLDLR internalisation and degradation	11	1.28e-01	0.265000	3.01e-01
Translation of structural proteins	26	1.95e-02	0.265000	9.60e-02
NCAM signaling for neurite out-growth	48	1.52e-03	0.265000	1.39e-02
Arachidonic acid metabolism	31	1.11e-02	0.264000	6.66e-02
Protein localization	137	1.06e-07	-0.263000	3.72e-06
Activated NOTCH1 Transmits Signal to the Nucleus	26	2.03e-02	0.263000	9.79e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	7.92e-02	0.262000	2.21e-01
Role of phospholipids in phagocytosis	22	3.36e-02	0.262000	1.35e-01
Cellular response to heat stress	84	3.77e-05	-0.260000	6.77e-04
ADORA2B mediated anti-inflammatory cytokines production	61	4.46e-04	0.260000	5.49e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.20e-01	0.259000	2.91e-01
Processive synthesis on the lagging strand	15	8.26e-02	0.259000	2.26e-01
Metabolism of non-coding RNA	45	2.91e-03	-0.257000	2.32e-02
snRNP Assembly	45	2.91e-03	-0.257000	2.32e-02
HSF1 activation	23	3.41e-02	-0.255000	1.36e-01
Diseases associated with the TLR signaling cascade	20	4.83e-02	0.255000	1.67e-01
Diseases of Immune System	20	4.83e-02	0.255000	1.67e-01
Signaling by KIT in disease	20	4.87e-02	0.255000	1.67e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	4.87e-02	0.255000	1.67e-01
Common Pathway of Fibrin Clot Formation	10	1.64e-01	0.254000	3.54e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	1.29e-01	0.253000	3.02e-01
RNA Polymerase II Pre-transcription Events	74	1.72e-04	-0.253000	2.54e-03
Transcription of the HIV genome	63	5.50e-04	-0.252000	6.32e-03
Biosynthesis of DHA-derived SPMs	10	1.70e-01	0.251000	3.63e-01
SUMOylation of immune response proteins	10	1.70e-01	0.250000	3.64e-01
Sialic acid metabolism	28	2.20e-02	0.250000	1.04e-01
Defective B4GALT7 causes EDS, progeroid type	17	7.44e-02	0.250000	2.14e-01
Antigen processing-Cross presentation	78	1.43e-04	0.249000	2.21e-03
Regulation of IFNG signaling	13	1.21e-01	0.249000	2.91e-01
Export of Viral Ribonucleoproteins from Nucleus	27	2.54e-02	-0.249000	1.15e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	1.22e-01	0.248000	2.92e-01
Regulation of RUNX1 Expression and Activity	17	7.74e-02	0.247000	2.18e-01
mRNA decay by 3' to 5' exoribonuclease	15	9.94e-02	-0.246000	2.54e-01
Processing of Capped Intronless Pre-mRNA	25	3.45e-02	-0.244000	1.37e-01
TP53 Regulates Transcription of Cell Cycle Genes	45	4.63e-03	0.244000	3.44e-02
Interconversion of nucleotide di- and triphosphates	24	3.87e-02	0.244000	1.46e-01
Retrograde transport at the Trans-Golgi-Network	42	6.28e-03	-0.244000	4.37e-02
Transcription of E2F targets under negative control by DREAM complex	18	7.45e-02	0.243000	2.14e-01
HDMs demethylate histones	22	4.89e-02	-0.243000	1.67e-01
Adenylate cyclase inhibitory pathway	13	1.30e-01	0.242000	3.04e-01
Condensation of Prophase Chromosomes	13	1.31e-01	0.242000	3.04e-01
Signaling by high-kinase activity BRAF mutants	31	1.96e-02	0.242000	9.60e-02
Transport of the SLBP independent Mature mRNA	29	2.41e-02	-0.242000	1.10e-01
Transport of Ribonucleoproteins into the Host Nucleus	26	3.28e-02	-0.242000	1.33e-01
Depolymerisation of the Nuclear Lamina	14	1.18e-01	0.241000	2.88e-01
Beta-catenin phosphorylation cascade	15	1.06e-01	-0.241000	2.66e-01
Eukaryotic Translation Elongation	57	1.66e-03	0.241000	1.51e-02
Activation of RAC1	10	1.88e-01	-0.240000	3.83e-01
Peptide ligand-binding receptors	57	1.73e-03	0.240000	1.57e-02
p130Cas linkage to MAPK signaling for integrins	12	1.50e-01	0.240000	3.34e-01
Polymerase switching on the C-strand of the telomere	23	4.68e-02	0.240000	1.65e-01
Cristae formation	10	1.90e-01	-0.239000	3.85e-01
Activation of the AP-1 family of transcription factors	10	1.91e-01	-0.239000	3.86e-01
Peptide chain elongation	53	2.65e-03	0.239000	2.19e-02
Presynaptic depolarization and calcium channel opening	11	1.71e-01	0.239000	3.64e-01
Peroxisomal lipid metabolism	24	4.54e-02	-0.236000	1.63e-01
Regulation of signaling by CBL	18	8.33e-02	0.236000	2.27e-01
RNA polymerase II transcribes snRNA genes	69	7.17e-04	-0.236000	7.81e-03
rRNA processing in the mitochondrion	14	1.28e-01	0.235000	3.01e-01
Repression of WNT target genes	12	1.60e-01	0.235000	3.49e-01
Synaptic adhesion-like molecules	18	8.51e-02	0.234000	2.30e-01
N-glycan antennae elongation in the medial/trans-Golgi	21	6.51e-02	0.233000	2.00e-01
Regulation of TP53 Activity through Association with Co-factors	12	1.64e-01	0.232000	3.53e-01
O-linked glycosylation of mucins	38	1.34e-02	0.232000	7.59e-02
Synthesis of PIPs at the late endosome membrane	11	1.83e-01	-0.232000	3.75e-01
Post-chaperonin tubulin folding pathway	14	1.35e-01	0.231000	3.11e-01
Diseases of carbohydrate metabolism	28	3.59e-02	-0.229000	1.40e-01
Hemostasis	448	1.67e-16	0.229000	3.17e-14
RHO GTPases Activate WASPs and WAVEs	35	1.97e-02	0.228000	9.60e-02
G alpha (s) signalling events	87	2.47e-04	0.228000	3.45e-03
Phase 2 - plateau phase	16	1.15e-01	0.227000	2.83e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	1.28e-01	-0.227000	3.01e-01
NEP/NS2 Interacts with the Cellular Export Machinery	26	4.55e-02	-0.227000	1.63e-01
Metabolism of amine-derived hormones	10	2.16e-01	0.226000	4.17e-01
Resolution of D-Loop Structures	31	2.98e-02	0.226000	1.27e-01
Extension of Telomeres	47	7.64e-03	0.225000	5.02e-02
Rho GTPase cycle	129	1.18e-05	0.224000	2.56e-04
Negative regulators of DDX58/IFIH1 signaling	29	3.71e-02	0.224000	1.43e-01
Synthesis of very long-chain fatty acyl-CoAs	14	1.48e-01	0.224000	3.30e-01
Synthesis of IP3 and IP4 in the cytosol	23	6.36e-02	0.224000	1.98e-01
Telomere C-strand (Lagging Strand) Synthesis	31	3.22e-02	0.222000	1.32e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	3.29e-02	-0.222000	1.33e-01
Formation of Incision Complex in GG-NER	39	1.70e-02	-0.221000	8.89e-02
The canonical retinoid cycle in rods (twilight vision)	12	1.86e-01	0.221000	3.79e-01
Interactions of Vpr with host cellular proteins	30	3.66e-02	-0.221000	1.42e-01
Signaling by Retinoic Acid	33	2.87e-02	-0.220000	1.24e-01
CRMPs in Sema3A signaling	15	1.40e-01	0.220000	3.20e-01
CTLA4 inhibitory signaling	21	8.17e-02	0.220000	2.25e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	2.08e-01	0.219000	4.09e-01
Other semaphorin interactions	19	9.81e-02	0.219000	2.54e-01
Cytochrome P450 - arranged by substrate type	31	3.51e-02	0.219000	1.39e-01
Transport of Mature mRNA Derived from an Intronless Transcript	36	2.37e-02	-0.218000	1.09e-01
mTORC1-mediated signalling	23	7.08e-02	-0.218000	2.07e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	30	3.99e-02	0.217000	1.47e-01
Platelet activation, signaling and aggregation	205	1.03e-07	0.216000	3.69e-06
Regulation of PTEN mRNA translation	11	2.15e-01	-0.216000	4.16e-01
GPCR downstream signalling	400	1.81e-13	0.216000	2.18e-11
Constitutive Signaling by Aberrant PI3K in Cancer	60	3.98e-03	0.215000	3.04e-02
Cytokine Signaling in Immune system	643	2.98e-20	0.215000	9.88e-18
FOXO-mediated transcription of cell cycle genes	16	1.37e-01	-0.215000	3.14e-01
Adenylate cyclase activating pathway	10	2.41e-01	0.214000	4.52e-01
Transport of the SLBP Dependant Mature mRNA	30	4.23e-02	-0.214000	1.55e-01
Telomere C-strand synthesis initiation	12	1.99e-01	0.214000	3.96e-01
Response to elevated platelet cytosolic Ca2+	101	2.11e-04	0.214000	2.98e-03
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	1.28e-01	0.214000	3.01e-01
Eukaryotic Translation Termination	56	5.80e-03	0.213000	4.12e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	1.83e-01	0.213000	3.75e-01
Viral mRNA Translation	53	7.35e-03	0.213000	4.88e-02
NRAGE signals death through JNK	55	6.33e-03	0.213000	4.38e-02
tRNA Aminoacylation	24	7.15e-02	-0.213000	2.08e-01
Signaling by Interleukins	339	2.13e-11	0.213000	1.67e-09
Signaling by GPCR	435	4.12e-14	0.213000	5.47e-12
Mucopolysaccharidoses	11	2.23e-01	-0.212000	4.26e-01
Ephrin signaling	19	1.09e-01	0.212000	2.72e-01
Removal of the Flap Intermediate	14	1.71e-01	0.211000	3.64e-01
Caspase activation via Dependence Receptors in the absence of ligand	10	2.48e-01	0.211000	4.58e-01
Cytosolic iron-sulfur cluster assembly	10	2.48e-01	0.211000	4.58e-01
tRNA processing in the nucleus	49	1.14e-02	-0.209000	6.76e-02
Association of TriC/CCT with target proteins during biosynthesis	37	2.89e-02	-0.208000	1.25e-01
Chondroitin sulfate/dermatan sulfate metabolism	44	1.72e-02	0.208000	8.94e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	1.79e-01	0.208000	3.71e-01
Signaling by Rho GTPases	339	7.80e-11	0.207000	4.93e-09
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	1.98e-01	0.206000	3.95e-01
Defective EXT2 causes exostoses 2	13	1.98e-01	0.206000	3.95e-01
Deposition of new CENPA-containing nucleosomes at the centromere	24	8.03e-02	0.206000	2.22e-01
Nucleosome assembly	24	8.03e-02	0.206000	2.22e-01
SUMOylation of SUMOylation proteins	28	5.91e-02	-0.206000	1.93e-01
Platelet degranulation	96	5.02e-04	0.206000	5.90e-03
Signaling by Erythropoietin	24	8.17e-02	0.205000	2.25e-01
NF-kB is activated and signals survival	11	2.40e-01	0.205000	4.52e-01
Homologous DNA Pairing and Strand Exchange	41	2.34e-02	0.205000	1.09e-01
TNFR2 non-canonical NF-kB pathway	73	2.59e-03	0.204000	2.16e-02
Chromosome Maintenance	83	1.45e-03	0.202000	1.38e-02
Metabolism of folate and pterines	15	1.75e-01	-0.202000	3.67e-01
TNFR1-induced NFkappaB signaling pathway	24	8.70e-02	0.202000	2.34e-01
Post-translational protein phosphorylation	68	4.15e-03	0.201000	3.15e-02
L1CAM interactions	86	1.28e-03	0.201000	1.27e-02
TCR signaling	99	5.62e-04	0.201000	6.32e-03
Mitochondrial tRNA aminoacylation	18	1.40e-01	-0.201000	3.20e-01
Apoptotic factor-mediated response	13	2.10e-01	0.201000	4.13e-01
DNA Replication Pre-Initiation	75	2.72e-03	0.200000	2.23e-02
Immune System	1522	3.13e-37	0.200000	4.15e-34
G beta:gamma signalling through PI3Kgamma	20	1.22e-01	0.200000	2.92e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	58	8.56e-03	0.200000	5.49e-02
CD28 co-stimulation	31	5.50e-02	0.199000	1.85e-01
RHO GTPases activate IQGAPs	10	2.77e-01	0.199000	4.92e-01
Intrinsic Pathway for Apoptosis	43	2.46e-02	0.198000	1.12e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	24	9.48e-02	-0.197000	2.49e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	37	3.92e-02	-0.196000	1.46e-01
Regulation of FZD by ubiquitination	16	1.75e-01	-0.196000	3.67e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	20	1.31e-01	-0.195000	3.04e-01
Recycling pathway of L1	27	7.97e-02	0.195000	2.22e-01
RHO GTPase Effectors	220	6.92e-07	0.195000	2.14e-05
Rev-mediated nuclear export of HIV RNA	29	7.01e-02	-0.194000	2.07e-01
EPH-Ephrin signaling	83	2.23e-03	0.194000	1.91e-02
Mitotic G1 phase and G1/S transition	136	9.38e-05	0.194000	1.54e-03
SUMOylation of transcription factors	13	2.25e-01	0.194000	4.30e-01
Receptor Mediated Mitophagy	10	2.88e-01	-0.194000	5.06e-01
LDL clearance	15	1.94e-01	0.194000	3.92e-01
Nuclear Pore Complex (NPC) Disassembly	30	6.70e-02	-0.193000	2.01e-01
RNA Polymerase I Transcription Termination	30	6.71e-02	-0.193000	2.01e-01
Synthesis of PIPs at the Golgi membrane	16	1.81e-01	-0.193000	3.73e-01
PCNA-Dependent Long Patch Base Excision Repair	21	1.26e-01	0.193000	2.98e-01
Ovarian tumor domain proteases	35	4.87e-02	0.193000	1.67e-01
NS1 Mediated Effects on Host Pathways	31	6.36e-02	-0.193000	1.98e-01
Plasma lipoprotein assembly, remodeling, and clearance	45	2.56e-02	0.192000	1.15e-01
WNT5A-dependent internalization of FZD4	15	1.98e-01	0.192000	3.95e-01
TNF signaling	36	4.79e-02	0.191000	1.67e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	22	1.22e-01	0.190000	2.92e-01
Glycosaminoglycan metabolism	100	1.04e-03	0.190000	1.06e-02
Cell surface interactions at the vascular wall	94	1.49e-03	0.190000	1.38e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	25	1.01e-01	-0.190000	2.56e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	25	1.01e-01	-0.190000	2.56e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	40	3.87e-02	0.189000	1.46e-01
Signaling by RAS mutants	40	3.87e-02	0.189000	1.46e-01
Signaling by moderate kinase activity BRAF mutants	40	3.87e-02	0.189000	1.46e-01
Signaling downstream of RAS mutants	40	3.87e-02	0.189000	1.46e-01
Formation of tubulin folding intermediates by CCT/TriC	17	1.80e-01	-0.188000	3.71e-01
Transcriptional activation of mitochondrial biogenesis	50	2.18e-02	-0.188000	1.04e-01
NGF-stimulated transcription	33	6.41e-02	0.186000	1.98e-01
Molecules associated with elastic fibres	28	8.94e-02	0.186000	2.39e-01
Interleukin-7 signaling	18	1.73e-01	0.186000	3.66e-01
Selenocysteine synthesis	56	1.65e-02	0.185000	8.78e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	17	1.86e-01	0.185000	3.79e-01
EPHB-mediated forward signaling	33	6.60e-02	0.185000	2.00e-01
Synthesis of PIPs at the early endosome membrane	16	2.00e-01	-0.185000	3.97e-01
Cilium Assembly	170	3.29e-05	-0.185000	6.07e-04
Signaling by RAF1 mutants	36	5.59e-02	0.184000	1.88e-01
Gap junction trafficking	12	2.70e-01	0.184000	4.86e-01
G-protein beta:gamma signalling	27	9.88e-02	0.184000	2.54e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	52	2.21e-02	0.184000	1.04e-01
Telomere Maintenance	61	1.32e-02	0.184000	7.57e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	75	6.17e-03	0.183000	4.33e-02
RNA Polymerase I Promoter Escape	30	8.30e-02	-0.183000	2.26e-01
PERK regulates gene expression	28	9.41e-02	-0.183000	2.48e-01
Late Phase of HIV Life Cycle	118	6.24e-04	-0.183000	6.97e-03
Interactions of Rev with host cellular proteins	30	8.49e-02	-0.182000	2.30e-01
Cross-presentation of soluble exogenous antigens (endosomes)	43	3.94e-02	0.182000	1.46e-01
G alpha (i) signalling events	202	9.02e-06	0.182000	2.10e-04
MHC class II antigen presentation	91	2.80e-03	0.181000	2.27e-02
Trafficking of GluR2-containing AMPA receptors	13	2.58e-01	0.181000	4.71e-01
Innate Immune System	735	1.35e-16	0.181000	2.98e-14
DNA Replication	117	7.33e-04	0.181000	7.91e-03
G alpha (q) signalling events	127	4.44e-04	0.181000	5.49e-03
Diseases associated with N-glycosylation of proteins	16	2.12e-01	-0.180000	4.14e-01
Metabolism of water-soluble vitamins and cofactors	101	1.77e-03	-0.180000	1.58e-02
Regulation of gene expression by Hypoxia-inducible Factor	11	3.01e-01	-0.180000	5.22e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	20	1.64e-01	0.180000	3.53e-01
mRNA Capping	28	1.00e-01	-0.180000	2.56e-01
RHO GTPases Activate Formins	110	1.22e-03	0.179000	1.22e-02
MTOR signalling	40	5.10e-02	-0.178000	1.73e-01
MAP2K and MAPK activation	35	6.84e-02	0.178000	2.03e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	3.09e-01	0.177000	5.29e-01
Killing mechanisms	11	3.10e-01	-0.177000	5.29e-01
WNT5:FZD7-mediated leishmania damping	11	3.10e-01	-0.177000	5.29e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	84	5.20e-03	0.177000	3.77e-02
Amplification of signal from the kinetochores	84	5.20e-03	0.177000	3.77e-02
Termination of translesion DNA synthesis	26	1.21e-01	0.176000	2.91e-01
Organelle biogenesis and maintenance	239	3.10e-06	-0.176000	8.57e-05
Vpr-mediated nuclear import of PICs	28	1.08e-01	-0.176000	2.69e-01
Glucagon-type ligand receptors	18	1.97e-01	0.176000	3.95e-01
G alpha (12/13) signalling events	70	1.13e-02	0.175000	6.74e-02
HS-GAG degradation	20	1.75e-01	0.175000	3.67e-01
TRAF6 mediated IRF7 activation	15	2.40e-01	0.175000	4.52e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	3.39e-01	-0.175000	5.51e-01
A tetrasaccharide linker sequence is required for GAG synthesis	22	1.56e-01	0.175000	3.45e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	3.40e-01	-0.174000	5.52e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	2.02e-01	0.174000	4.01e-01
COPI-mediated anterograde transport	75	9.53e-03	-0.173000	5.97e-02
Neurexins and neuroligins	48	3.79e-02	0.173000	1.45e-01
Cytosolic sulfonation of small molecules	17	2.17e-01	-0.173000	4.19e-01
G2/M Checkpoints	122	9.98e-04	0.173000	1.02e-02
ER-Phagosome pathway	64	1.71e-02	0.173000	8.89e-02
NOTCH3 Intracellular Domain Regulates Transcription	19	1.94e-01	0.172000	3.91e-01
Nuclear import of Rev protein	27	1.21e-01	-0.172000	2.92e-01
Miscellaneous transport and binding events	17	2.19e-01	-0.172000	4.22e-01
Establishment of Sister Chromatid Cohesion	10	3.47e-01	-0.172000	5.55e-01
Activation of BH3-only proteins	27	1.23e-01	0.172000	2.92e-01
Regulation of RUNX3 expression and activity	48	3.97e-02	0.172000	1.47e-01
Nervous system development	457	4.30e-10	0.172000	2.38e-08
PINK1-PRKN Mediated Mitophagy	16	2.35e-01	-0.172000	4.45e-01
Formation of the beta-catenin:TCF transactivating complex	31	9.87e-02	0.171000	2.54e-01
Phase II - Conjugation of compounds	63	1.89e-02	-0.171000	9.52e-02
Diseases associated with glycosylation precursor biosynthesis	17	2.22e-01	-0.171000	4.25e-01
Maturation of nucleoprotein	10	3.50e-01	0.171000	5.56e-01
Metabolism of nitric oxide: NOS3 activation and regulation	14	2.70e-01	0.170000	4.86e-01
HDR through Single Strand Annealing (SSA)	36	7.85e-02	0.170000	2.19e-01
mRNA Splicing	176	1.11e-04	-0.169000	1.80e-03
Interleukin-15 signaling	13	2.91e-01	0.169000	5.09e-01
Presynaptic phase of homologous DNA pairing and strand exchange	38	7.12e-02	0.169000	2.07e-01
FRS-mediated FGFR3 signaling	14	2.74e-01	-0.169000	4.90e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	23	1.61e-01	0.169000	3.51e-01
Formation of RNA Pol II elongation complex	53	3.39e-02	-0.169000	1.35e-01
RNA Polymerase II Transcription Elongation	53	3.39e-02	-0.169000	1.35e-01
Processing of Capped Intron-Containing Pre-mRNA	220	1.85e-05	-0.168000	3.68e-04
MET activates RAP1 and RAC1	11	3.35e-01	-0.168000	5.49e-01
Response of EIF2AK1 (HRI) to heme deficiency	13	2.95e-01	-0.168000	5.14e-01
CLEC7A (Dectin-1) induces NFAT activation	10	3.58e-01	-0.168000	5.60e-01
mRNA Splicing - Major Pathway	168	1.84e-04	-0.168000	2.68e-03
Inactivation, recovery and regulation of the phototransduction cascade	17	2.32e-01	-0.168000	4.41e-01
The phototransduction cascade	17	2.32e-01	-0.168000	4.41e-01
mRNA decay by 5' to 3' exoribonuclease	15	2.61e-01	-0.168000	4.77e-01
eNOS activation	10	3.59e-01	0.167000	5.60e-01
FRS-mediated FGFR1 signaling	16	2.47e-01	-0.167000	4.58e-01
ZBP1(DAI) mediated induction of type I IFNs	20	1.96e-01	0.167000	3.93e-01
Semaphorin interactions	63	2.19e-02	0.167000	1.04e-01
Plasma lipoprotein remodeling	14	2.80e-01	0.167000	4.96e-01
Axon guidance	439	2.58e-09	0.167000	1.32e-07
SUMOylation of DNA methylation proteins	16	2.48e-01	0.167000	4.58e-01
G beta:gamma signalling through CDC42	15	2.65e-01	-0.166000	4.80e-01
ERK/MAPK targets	22	1.77e-01	-0.166000	3.68e-01
Growth hormone receptor signaling	19	2.11e-01	0.166000	4.13e-01
Deadenylation-dependent mRNA decay	54	3.53e-02	-0.166000	1.39e-01
Signal amplification	26	1.44e-01	0.166000	3.26e-01
Processing of DNA double-strand break ends	57	3.08e-02	0.166000	1.30e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.84e-02	0.164000	9.45e-02
Death Receptor Signalling	122	1.76e-03	0.164000	1.58e-02
Inwardly rectifying K+ channels	23	1.73e-01	-0.164000	3.66e-01
RNA Pol II CTD phosphorylation and interaction with CE	26	1.49e-01	-0.164000	3.31e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	1.49e-01	-0.164000	3.31e-01
Signaling by NOTCH3	40	7.35e-02	0.164000	2.12e-01
Nuclear signaling by ERBB4	27	1.42e-01	0.163000	3.22e-01
Fertilization	12	3.27e-01	0.163000	5.46e-01
Formation of a pool of free 40S subunits	63	2.52e-02	0.163000	1.14e-01
Effects of PIP2 hydrolysis	23	1.76e-01	0.163000	3.68e-01
MET promotes cell motility	28	1.37e-01	0.162000	3.14e-01
Uptake and actions of bacterial toxins	26	1.52e-01	0.162000	3.38e-01
G1/S Transition	119	2.36e-03	0.162000	1.99e-02
Neutrophil degranulation	345	2.89e-07	0.162000	9.58e-06
NOD1/2 Signaling Pathway	29	1.35e-01	0.160000	3.11e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	68	2.23e-02	0.160000	1.05e-01
Adrenaline,noradrenaline inhibits insulin secretion	21	2.05e-01	0.160000	4.05e-01
p75 NTR receptor-mediated signalling	85	1.12e-02	0.159000	6.67e-02
SCF(Skp2)-mediated degradation of p27/p21	52	4.69e-02	0.159000	1.65e-01
G alpha (z) signalling events	38	9.04e-02	0.159000	2.41e-01
Adaptive Immune System	581	8.85e-11	0.159000	5.34e-09
Phase 4 - resting membrane potential	10	3.85e-01	0.159000	5.85e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	2.72e-01	-0.159000	4.88e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	26	1.63e-01	0.158000	3.53e-01
Signaling by FGFR2 IIIa TM	18	2.48e-01	-0.157000	4.58e-01
Cell Cycle Checkpoints	234	3.57e-05	0.157000	6.50e-04
Signal transduction by L1	21	2.12e-01	0.157000	4.14e-01
Signaling by the B Cell Receptor (BCR)	98	7.23e-03	0.157000	4.85e-02
Striated Muscle Contraction	33	1.18e-01	0.157000	2.88e-01
CaM pathway	33	1.19e-01	0.157000	2.89e-01
Calmodulin induced events	33	1.19e-01	0.157000	2.89e-01
Transcriptional regulation by RUNX2	99	7.28e-03	0.156000	4.85e-02
Signaling by NTRK2 (TRKB)	25	1.76e-01	0.156000	3.68e-01
mRNA Splicing - Minor Pathway	48	6.19e-02	-0.156000	1.98e-01
EPHA-mediated growth cone collapse	15	2.96e-01	0.156000	5.16e-01
Synthesis of DNA	110	5.04e-03	0.155000	3.70e-02
HIV Life Cycle	130	2.35e-03	-0.155000	1.99e-02
Translation	224	7.62e-05	-0.154000	1.26e-03
Ca-dependent events	35	1.15e-01	0.154000	2.83e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	34	1.22e-01	-0.153000	2.92e-01
WNT ligand biogenesis and trafficking	15	3.04e-01	-0.153000	5.23e-01
Telomere Extension By Telomerase	22	2.13e-01	0.153000	4.15e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	3.58e-01	0.153000	5.60e-01
Initiation of Nuclear Envelope (NE) Reformation	19	2.48e-01	0.153000	4.58e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	67	3.11e-02	0.152000	1.31e-01
DCC mediated attractive signaling	14	3.24e-01	0.152000	5.43e-01
APC/C-mediated degradation of cell cycle proteins	79	1.95e-02	0.152000	9.60e-02
Regulation of mitotic cell cycle	79	1.95e-02	0.152000	9.60e-02
PI3K/AKT Signaling in Cancer	87	1.44e-02	0.152000	7.99e-02
O-linked glycosylation	75	2.38e-02	0.151000	1.09e-01
Pentose phosphate pathway	13	3.46e-01	-0.151000	5.55e-01
APC-Cdc20 mediated degradation of Nek2A	24	2.01e-01	0.151000	3.98e-01
Gene Silencing by RNA	61	4.19e-02	-0.151000	1.54e-01
Amino acids regulate mTORC1	46	7.71e-02	-0.151000	2.18e-01
IKK complex recruitment mediated by RIP1	18	2.69e-01	0.151000	4.84e-01
SARS-CoV-1 Infection	41	9.54e-02	0.151000	2.49e-01
G1/S DNA Damage Checkpoints	58	4.79e-02	0.150000	1.67e-01
NoRC negatively regulates rRNA expression	45	8.13e-02	-0.150000	2.24e-01
Heme biosynthesis	13	3.49e-01	-0.150000	5.55e-01
p75NTR recruits signalling complexes	10	4.11e-01	0.150000	6.12e-01
p75NTR signals via NF-kB	13	3.49e-01	0.150000	5.55e-01
Negative epigenetic regulation of rRNA expression	48	7.27e-02	-0.150000	2.11e-01
Downregulation of ERBB2 signaling	25	1.95e-01	0.150000	3.93e-01
Regulation of APC/C activators between G1/S and early anaphase	72	2.83e-02	0.150000	1.23e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	62	4.27e-02	0.149000	1.56e-01
Oncogene Induced Senescence	30	1.58e-01	0.149000	3.47e-01
Cell-Cell communication	85	1.81e-02	0.149000	9.33e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	89	1.56e-02	0.149000	8.44e-02
Mitochondrial biogenesis	69	3.32e-02	-0.148000	1.34e-01
Dual incision in TC-NER	62	4.36e-02	-0.148000	1.58e-01
Transcriptional regulation by small RNAs	41	1.01e-01	-0.148000	2.56e-01
SUMOylation of ubiquitinylation proteins	32	1.47e-01	-0.148000	3.30e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	63	4.34e-02	-0.147000	1.58e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	53	6.39e-02	0.147000	1.98e-01
Signal Transduction	1748	2.96e-23	0.147000	1.97e-20
Viral Messenger RNA Synthesis	37	1.22e-01	-0.147000	2.92e-01
Neurotransmitter release cycle	31	1.57e-01	-0.147000	3.45e-01
FCERI mediated MAPK activation	28	1.79e-01	0.147000	3.71e-01
Nicotinamide salvaging	13	3.60e-01	0.147000	5.60e-01
Activation of ATR in response to replication stress	36	1.28e-01	0.147000	3.01e-01
mRNA 3'-end processing	51	7.06e-02	-0.146000	2.07e-01
Resolution of Sister Chromatid Cohesion	96	1.33e-02	0.146000	7.57e-02
Signaling by VEGF	97	1.29e-02	0.146000	7.47e-02
Signaling by Receptor Tyrosine Kinases	423	3.20e-07	0.146000	1.04e-05
Protein-protein interactions at synapses	69	3.65e-02	0.146000	1.42e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	2.96e-02	-0.145000	1.27e-01
Signaling by Non-Receptor Tyrosine Kinases	49	7.84e-02	0.145000	2.19e-01
Signaling by PTK6	49	7.84e-02	0.145000	2.19e-01
G2/M DNA damage checkpoint	57	5.83e-02	0.145000	1.92e-01
MECP2 regulates neuronal receptors and channels	13	3.65e-01	-0.145000	5.67e-01
HDR through Homologous Recombination (HRR)	62	4.86e-02	0.145000	1.67e-01
Metabolism of cofactors	18	2.87e-01	-0.145000	5.06e-01
Long-term potentiation	19	2.75e-01	0.145000	4.91e-01
IL-6-type cytokine receptor ligand interactions	13	3.68e-01	-0.144000	5.70e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.35e-01	0.144000	3.11e-01
Diseases of mitotic cell cycle	36	1.35e-01	0.144000	3.11e-01
CD28 dependent PI3K/Akt signaling	20	2.66e-01	0.144000	4.81e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	9.92e-02	0.144000	2.54e-01
p53-Independent DNA Damage Response	44	9.92e-02	0.144000	2.54e-01
p53-Independent G1/S DNA damage checkpoint	44	9.92e-02	0.144000	2.54e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	65	4.58e-02	0.143000	1.63e-01
RNA Polymerase II Transcription Termination	59	5.71e-02	-0.143000	1.91e-01
Gap junction trafficking and regulation	14	3.54e-01	0.143000	5.56e-01
p53-Dependent G1 DNA Damage Response	56	6.43e-02	0.143000	1.98e-01
p53-Dependent G1/S DNA damage checkpoint	56	6.43e-02	0.143000	1.98e-01
MAP kinase activation	59	5.79e-02	-0.143000	1.92e-01
Glycolysis	57	6.26e-02	-0.143000	1.98e-01
Mitotic Spindle Checkpoint	101	1.33e-02	0.143000	7.58e-02
Homology Directed Repair	95	1.65e-02	0.142000	8.79e-02
Prefoldin mediated transfer of substrate to CCT/TriC	22	2.48e-01	-0.142000	4.58e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	86	2.27e-02	0.142000	1.06e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	19	2.84e-01	0.142000	5.01e-01
Smooth Muscle Contraction	34	1.52e-01	0.142000	3.37e-01
E3 ubiquitin ligases ubiquitinate target proteins	38	1.30e-01	-0.142000	3.04e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	3.43e-01	0.141000	5.55e-01
Dopamine Neurotransmitter Release Cycle	16	3.28e-01	-0.141000	5.46e-01
Cell-extracellular matrix interactions	16	3.31e-01	0.140000	5.48e-01
COPII-mediated vesicle transport	59	6.25e-02	-0.140000	1.98e-01
Purine catabolism	15	3.47e-01	0.140000	5.55e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	60	6.04e-02	0.140000	1.95e-01
Sema3A PAK dependent Axon repulsion	16	3.32e-01	0.140000	5.48e-01
Retrograde neurotrophin signalling	13	3.83e-01	0.140000	5.85e-01
tRNA modification in the nucleus and cytosol	36	1.47e-01	-0.140000	3.30e-01
Unblocking of NMDA receptors, glutamate binding and activation	17	3.19e-01	0.140000	5.40e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	4.24e-01	0.139000	6.24e-01
PLC beta mediated events	48	9.58e-02	0.139000	2.49e-01
ER to Golgi Anterograde Transport	119	9.01e-03	-0.139000	5.70e-02
Glucose metabolism	74	3.94e-02	-0.139000	1.46e-01
EML4 and NUDC in mitotic spindle formation	88	2.48e-02	0.139000	1.13e-01
G-protein mediated events	49	9.45e-02	0.138000	2.49e-01
Regulation of TP53 Activity through Acetylation	29	1.99e-01	0.138000	3.96e-01
Elevation of cytosolic Ca2+ levels	12	4.09e-01	0.138000	6.12e-01
TRAF6 mediated NF-kB activation	20	2.90e-01	0.137000	5.08e-01
Signaling by NTRK3 (TRKC)	17	3.29e-01	0.137000	5.47e-01
TP53 Regulates Metabolic Genes	81	3.39e-02	-0.137000	1.35e-01
Assembly of the pre-replicative complex	59	7.10e-02	0.136000	2.07e-01
Senescence-Associated Secretory Phenotype (SASP)	45	1.15e-01	0.136000	2.83e-01
PCP/CE pathway	83	3.26e-02	0.136000	1.33e-01
Activation of AMPK downstream of NMDARs	10	4.59e-01	0.135000	6.56e-01
Hedgehog 'on' state	73	4.64e-02	0.135000	1.65e-01
Transcriptional regulation by RUNX3	89	2.80e-02	0.135000	1.23e-01
Transport of Mature Transcript to Cytoplasm	72	4.83e-02	-0.135000	1.67e-01
RIP-mediated NFkB activation via ZBP1	16	3.54e-01	0.134000	5.56e-01
L13a-mediated translational silencing of Ceruloplasmin expression	71	5.15e-02	0.134000	1.74e-01
Metabolism of vitamins and cofactors	147	5.33e-03	-0.133000	3.84e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation	30	2.07e-01	0.133000	4.07e-01
Negative regulation of MET activity	18	3.28e-01	0.133000	5.46e-01
Signaling by MET	58	7.98e-02	0.133000	2.22e-01
Diseases of programmed cell death	20	3.04e-01	0.133000	5.23e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	9.20e-02	-0.133000	2.44e-01
RNA Polymerase III Transcription Initiation	35	1.75e-01	-0.132000	3.67e-01
Triglyceride catabolism	16	3.59e-01	-0.132000	5.60e-01
Negative regulation of the PI3K/AKT network	92	2.87e-02	0.132000	1.24e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	64	6.93e-02	0.131000	2.05e-01
HS-GAG biosynthesis	24	2.68e-01	0.131000	4.84e-01
Developmental Biology	674	1.10e-08	0.130000	4.41e-07
Mitotic Metaphase and Anaphase	202	1.46e-03	0.130000	1.38e-02
Cyclin A:Cdk2-associated events at S phase entry	77	4.86e-02	0.130000	1.67e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	4.76e-01	-0.130000	6.69e-01
SHC1 events in ERBB4 signaling	13	4.17e-01	0.130000	6.17e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	4.36e-01	-0.130000	6.34e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	25	2.62e-01	-0.130000	4.78e-01
Phase 0 - rapid depolarisation	34	1.92e-01	0.129000	3.87e-01
Activation of G protein gated Potassium channels	18	3.42e-01	-0.129000	5.55e-01
G protein gated Potassium channels	18	3.42e-01	-0.129000	5.55e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	3.42e-01	-0.129000	5.55e-01
Glycosphingolipid metabolism	35	1.86e-01	0.129000	3.79e-01
SUMOylation of RNA binding proteins	40	1.58e-01	-0.129000	3.46e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	1.60e-01	-0.129000	3.49e-01
Golgi Cisternae Pericentriolar Stack Reorganization	13	4.25e-01	0.128000	6.24e-01
Interleukin-1 family signaling	111	2.02e-02	0.128000	9.79e-02
Sema4D induced cell migration and growth-cone collapse	20	3.23e-01	0.128000	5.43e-01
Metabolism of polyamines	51	1.16e-01	0.127000	2.83e-01
VEGFR2 mediated cell proliferation	18	3.50e-01	0.127000	5.55e-01
RAF-independent MAPK1/3 activation	21	3.12e-01	0.127000	5.31e-01
Signaling by ERBB2	44	1.45e-01	0.127000	3.26e-01
Mitotic Anaphase	201	1.96e-03	0.127000	1.72e-02
Programmed Cell Death	144	8.75e-03	0.127000	5.59e-02
APC/C:Cdc20 mediated degradation of Cyclin B	22	3.04e-01	0.127000	5.23e-01
Basigin interactions	21	3.19e-01	-0.126000	5.40e-01
HCMV Late Events	46	1.42e-01	-0.125000	3.22e-01
MyD88 cascade initiated on plasma membrane	74	6.30e-02	-0.125000	1.98e-01
Toll Like Receptor 10 (TLR10) Cascade	74	6.30e-02	-0.125000	1.98e-01
Toll Like Receptor 5 (TLR5) Cascade	74	6.30e-02	-0.125000	1.98e-01
RNA Polymerase III Abortive And Retractive Initiation	40	1.72e-01	-0.125000	3.65e-01
RNA Polymerase III Transcription	40	1.72e-01	-0.125000	3.65e-01
Infection with Mycobacterium tuberculosis	22	3.12e-01	0.125000	5.31e-01
Protein ubiquitination	55	1.12e-01	-0.124000	2.78e-01
Macroautophagy	101	3.19e-02	-0.124000	1.32e-01
Insulin receptor recycling	19	3.51e-01	-0.124000	5.56e-01
ERBB2 Activates PTK6 Signaling	11	4.78e-01	0.123000	6.70e-01
Signaling by BRAF and RAF fusions	57	1.08e-01	0.123000	2.69e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	4.60e-01	-0.123000	6.56e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	47	1.44e-01	0.123000	3.26e-01
Signalling to RAS	18	3.68e-01	0.123000	5.70e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	19	3.56e-01	0.122000	5.59e-01
Neurodegenerative Diseases	19	3.56e-01	0.122000	5.59e-01
Transport of bile salts and organic acids, metal ions and amine compounds	49	1.39e-01	0.122000	3.18e-01
Ubiquitin-dependent degradation of Cyclin D	44	1.61e-01	0.122000	3.51e-01
Norepinephrine Neurotransmitter Release Cycle	13	4.46e-01	-0.122000	6.46e-01
PKA activation in glucagon signalling	16	4.00e-01	0.122000	6.05e-01
S Phase	150	1.04e-02	0.122000	6.40e-02
Sphingolipid metabolism	68	8.41e-02	0.121000	2.28e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	73	7.36e-02	0.121000	2.12e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	2.68e-01	-0.121000	4.84e-01
SCF-beta-TrCP mediated degradation of Emi1	47	1.55e-01	0.120000	3.44e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	30	2.58e-01	0.119000	4.71e-01
Cyclin D associated events in G1	42	1.81e-01	0.119000	3.73e-01
G1 Phase	42	1.81e-01	0.119000	3.73e-01
Transferrin endocytosis and recycling	23	3.22e-01	-0.119000	5.43e-01
Metabolism of nucleotides	82	6.35e-02	0.119000	1.98e-01
Regulation of ornithine decarboxylase (ODC)	45	1.69e-01	0.119000	3.62e-01
Interleukin-17 signaling	63	1.04e-01	-0.118000	2.64e-01
Regulation of expression of SLITs and ROBOs	118	2.66e-02	0.118000	1.17e-01
Cytochrome c-mediated apoptotic response	10	5.20e-01	0.118000	7.02e-01
Mitophagy	23	3.30e-01	-0.118000	5.47e-01
COPI-dependent Golgi-to-ER retrograde traffic	76	7.72e-02	0.117000	2.18e-01
CDK-mediated phosphorylation and removal of Cdc6	64	1.05e-01	0.117000	2.64e-01
Cell Cycle, Mitotic	450	2.28e-05	0.117000	4.38e-04
Amyloid fiber formation	33	2.45e-01	0.117000	4.58e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	61	1.15e-01	-0.117000	2.83e-01
CLEC7A (Dectin-1) signaling	87	6.01e-02	0.117000	1.95e-01
DSCAM interactions	10	5.23e-01	0.117000	7.03e-01
Class B/2 (Secretin family receptors)	48	1.62e-01	0.117000	3.53e-01
Free fatty acids regulate insulin secretion	10	5.23e-01	0.117000	7.03e-01
Cell Cycle	561	3.46e-06	0.116000	9.38e-05
Separation of Sister Chromatids	153	1.38e-02	0.116000	7.77e-02
Cyclin E associated events during G1/S transition	75	8.42e-02	0.115000	2.28e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	66	1.08e-01	0.115000	2.69e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	10	5.33e-01	0.114000	7.07e-01
Activation of SMO	13	4.78e-01	0.114000	6.70e-01
Deadenylation of mRNA	24	3.36e-01	-0.114000	5.49e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	16	4.32e-01	-0.113000	6.33e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	4.33e-01	-0.113000	6.33e-01
Downstream signal transduction	28	3.00e-01	0.113000	5.21e-01
HATs acetylate histones	73	9.51e-02	-0.113000	2.49e-01
Platelet homeostasis	73	9.52e-02	0.113000	2.49e-01
MASTL Facilitates Mitotic Progression	10	5.36e-01	-0.113000	7.07e-01
Protein methylation	10	5.36e-01	-0.113000	7.07e-01
Stabilization of p53	48	1.78e-01	0.112000	3.71e-01
Synthesis of substrates in N-glycan biosythesis	56	1.46e-01	0.112000	3.29e-01
Sphingolipid de novo biosynthesis	33	2.65e-01	0.112000	4.80e-01
Interleukin-12 family signaling	47	1.84e-01	0.112000	3.77e-01
Retinoid metabolism and transport	25	3.34e-01	0.112000	5.49e-01
FLT3 Signaling	242	2.92e-03	0.111000	2.32e-02
VEGFA-VEGFR2 Pathway	89	6.99e-02	0.111000	2.07e-01
PI-3K cascade:FGFR1	14	4.73e-01	-0.111000	6.67e-01
Apoptosis	141	2.35e-02	0.111000	1.09e-01
Resolution of Abasic Sites (AP sites)	37	2.44e-01	0.111000	4.57e-01
TBC/RABGAPs	38	2.40e-01	0.110000	4.52e-01
MAPK1/MAPK3 signaling	234	3.87e-03	0.110000	2.97e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	24	3.52e-01	-0.110000	5.56e-01
Recognition of DNA damage by PCNA-containing replication complex	27	3.24e-01	0.110000	5.43e-01
RAF/MAP kinase cascade	229	4.39e-03	0.110000	3.31e-02
ATF4 activates genes in response to endoplasmic reticulum stress	24	3.53e-01	-0.110000	5.56e-01
Glycogen metabolism	24	3.53e-01	-0.110000	5.56e-01
tRNA processing	99	6.01e-02	-0.110000	1.95e-01
Carnitine metabolism	11	5.30e-01	-0.109000	7.06e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	2.21e-01	0.109000	4.24e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	5.13e-01	0.109000	6.96e-01
Glutathione synthesis and recycling	10	5.51e-01	-0.109000	7.21e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	3.56e-01	0.109000	5.59e-01
Hyaluronan metabolism	16	4.52e-01	0.109000	6.52e-01
Signaling by NOTCH	155	2.03e-02	0.108000	9.79e-02
SUMOylation of chromatin organization proteins	47	1.99e-01	-0.108000	3.97e-01
PRC2 methylates histones and DNA	14	4.84e-01	0.108000	6.76e-01
Cell junction organization	54	1.71e-01	0.108000	3.64e-01
Orc1 removal from chromatin	61	1.46e-01	0.108000	3.29e-01
Dectin-1 mediated noncanonical NF-kB signaling	52	1.82e-01	0.107000	3.73e-01
Vpu mediated degradation of CD4	44	2.19e-01	0.107000	4.22e-01
Base Excision Repair	45	2.15e-01	0.107000	4.17e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	3.48e-01	-0.106000	5.55e-01
p38MAPK events	12	5.27e-01	0.106000	7.03e-01
Phosphorylation of the APC/C	20	4.16e-01	0.105000	6.17e-01
Detoxification of Reactive Oxygen Species	29	3.27e-01	0.105000	5.46e-01
Intra-Golgi traffic	40	2.50e-01	-0.105000	4.62e-01
RAB geranylgeranylation	45	2.23e-01	0.105000	4.27e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	3.46e-01	-0.105000	5.55e-01
C-type lectin receptors (CLRs)	108	6.09e-02	0.105000	1.96e-01
CS/DS degradation	12	5.31e-01	-0.105000	7.06e-01
Degradation of DVL	48	2.12e-01	0.104000	4.14e-01
Downstream TCR signaling	77	1.15e-01	0.104000	2.83e-01
Autodegradation of the E3 ubiquitin ligase COP1	44	2.34e-01	0.104000	4.45e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	4.11e-01	0.104000	6.12e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	4.11e-01	0.104000	6.12e-01
Cap-dependent Translation Initiation	79	1.12e-01	0.104000	2.78e-01
Eukaryotic Translation Initiation	79	1.12e-01	0.104000	2.78e-01
Activation of gene expression by SREBF (SREBP)	41	2.51e-01	-0.104000	4.63e-01
Nucleotide Excision Repair	104	6.84e-02	-0.104000	2.03e-01
RUNX2 regulates osteoblast differentiation	19	4.35e-01	0.103000	6.34e-01
PI3K events in ERBB2 signaling	15	4.88e-01	0.103000	6.77e-01
PI-3K cascade:FGFR3	12	5.35e-01	-0.103000	7.07e-01
Regulation of insulin secretion	63	1.58e-01	0.103000	3.46e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	12	5.37e-01	0.103000	7.07e-01
FRS-mediated FGFR2 signaling	17	4.64e-01	-0.103000	6.58e-01
Autophagy	113	6.07e-02	-0.102000	1.96e-01
Signaling by FGFR3	32	3.17e-01	-0.102000	5.37e-01
Regulation of PTEN stability and activity	60	1.71e-01	0.102000	3.64e-01
Cargo concentration in the ER	25	3.78e-01	-0.102000	5.83e-01
CaMK IV-mediated phosphorylation of CREB	10	5.78e-01	0.102000	7.42e-01
Oncogenic MAPK signaling	73	1.34e-01	0.101000	3.11e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	12	5.43e-01	0.101000	7.15e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	2.80e-01	-0.101000	4.96e-01
HIV Transcription Elongation	38	2.80e-01	-0.101000	4.96e-01
Tat-mediated elongation of the HIV-1 transcript	38	2.80e-01	-0.101000	4.96e-01
Chromatin modifying enzymes	183	1.85e-02	-0.101000	9.45e-02
Chromatin organization	183	1.85e-02	-0.101000	9.45e-02
NR1H2 and NR1H3-mediated signaling	37	2.88e-01	0.101000	5.06e-01
Zinc transporters	12	5.46e-01	-0.101000	7.17e-01
Constitutive Signaling by Overexpressed ERBB2	10	5.82e-01	0.100000	7.44e-01
Diseases associated with glycosaminoglycan metabolism	34	3.11e-01	0.100000	5.31e-01
Interaction between L1 and Ankyrins	22	4.16e-01	0.100000	6.17e-01
Infectious disease	559	5.92e-05	0.100000	1.02e-03
Signaling by FGFR3 in disease	16	4.89e-01	-0.099900	6.77e-01
Signaling by FGFR3 point mutants in cancer	16	4.89e-01	-0.099900	6.77e-01
Rab regulation of trafficking	111	7.02e-02	0.099600	2.07e-01
Negative regulation of NOTCH4 signaling	48	2.34e-01	0.099300	4.45e-01
Selenoamino acid metabolism	69	1.56e-01	0.098900	3.45e-01
STING mediated induction of host immune responses	12	5.54e-01	0.098700	7.22e-01
Nucleotide salvage	19	4.57e-01	0.098600	6.56e-01
Fc epsilon receptor (FCERI) signaling	118	6.64e-02	0.098000	2.00e-01
Formation of the Early Elongation Complex	32	3.38e-01	-0.097900	5.51e-01
Formation of the HIV-1 Early Elongation Complex	32	3.38e-01	-0.097900	5.51e-01
ERBB2 Regulates Cell Motility	14	5.27e-01	0.097700	7.03e-01
Downstream signaling of activated FGFR1	24	4.11e-01	-0.096900	6.12e-01
Erythropoietin activates RAS	13	5.47e-01	0.096600	7.17e-01
Diseases of DNA repair	10	5.97e-01	-0.096600	7.51e-01
Signaling by Hippo	18	4.78e-01	-0.096500	6.70e-01
SARS-CoV Infections	76	1.48e-01	0.096100	3.31e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	5.50e-01	-0.095800	7.20e-01
Asymmetric localization of PCP proteins	56	2.16e-01	0.095700	4.17e-01
EGFR downregulation	25	4.08e-01	0.095600	6.12e-01
DAG and IP3 signaling	39	3.03e-01	0.095400	5.23e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	32	3.52e-01	0.095100	5.56e-01
Olfactory Signaling Pathway	16	5.11e-01	-0.094900	6.96e-01
rRNA processing	161	3.88e-02	0.094600	1.46e-01
Cleavage of the damaged pyrimidine	16	5.13e-01	0.094500	6.96e-01
Depyrimidination	16	5.13e-01	0.094500	6.96e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	5.13e-01	0.094500	6.96e-01
RHO GTPases activate PKNs	31	3.69e-01	-0.093200	5.71e-01
Formation of the ternary complex, and subsequently, the 43S complex	38	3.21e-01	0.093100	5.43e-01
Metabolism of steroid hormones	17	5.10e-01	0.092400	6.96e-01
Cellular hexose transport	11	5.96e-01	-0.092300	7.50e-01
RHO GTPases Activate ROCKs	19	4.87e-01	-0.092100	6.77e-01
Downregulation of TGF-beta receptor signaling	23	4.46e-01	-0.091900	6.46e-01
TICAM1, RIP1-mediated IKK complex recruitment	16	5.25e-01	0.091800	7.03e-01
RET signaling	35	3.50e-01	0.091400	5.55e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	5.69e-01	0.091100	7.37e-01
HCMV Early Events	53	2.52e-01	-0.091000	4.64e-01
PKA activation	17	5.17e-01	0.090800	6.99e-01
Mitotic Telophase/Cytokinesis	12	5.89e-01	-0.090100	7.46e-01
Signaling by PDGFR in disease	20	4.86e-01	0.090100	6.77e-01
VEGFR2 mediated vascular permeability	26	4.27e-01	0.090000	6.27e-01
Negative regulation of FGFR1 signaling	23	4.55e-01	-0.090000	6.54e-01
Downstream signaling of activated FGFR3	19	4.97e-01	-0.090000	6.84e-01
Reduction of cytosolic Ca++ levels	12	5.90e-01	-0.089800	7.47e-01
Cholesterol biosynthesis	23	4.56e-01	-0.089700	6.55e-01
Base-Excision Repair, AP Site Formation	18	5.10e-01	0.089700	6.96e-01
Translation initiation complex formation	44	3.04e-01	0.089700	5.23e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	4.47e-01	-0.089600	6.46e-01
Listeria monocytogenes entry into host cells	16	5.35e-01	0.089600	7.07e-01
Postmitotic nuclear pore complex (NPC) reformation	24	4.49e-01	-0.089400	6.48e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	16	5.37e-01	-0.089300	7.07e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	78	1.74e-01	0.089200	3.66e-01
Nonsense-Mediated Decay (NMD)	78	1.74e-01	0.089200	3.66e-01
Vif-mediated degradation of APOBEC3G	43	3.12e-01	0.089100	5.31e-01
Switching of origins to a post-replicative state	81	1.66e-01	0.089100	3.58e-01
Serotonin Neurotransmitter Release Cycle	12	5.93e-01	-0.089000	7.49e-01
Autodegradation of Cdh1 by Cdh1:APC/C	58	2.47e-01	0.087900	4.58e-01
Antiviral mechanism by IFN-stimulated genes	67	2.14e-01	0.087900	4.15e-01
SHC1 events in ERBB2 signaling	21	4.87e-01	0.087700	6.77e-01
Golgi Associated Vesicle Biogenesis	52	2.75e-01	-0.087600	4.91e-01
Interleukin-6 signaling	10	6.32e-01	0.087500	7.77e-01
NIK-->noncanonical NF-kB signaling	50	2.87e-01	0.087200	5.06e-01
APC/C:Cdc20 mediated degradation of Securin	60	2.45e-01	0.086800	4.58e-01
GABA synthesis, release, reuptake and degradation	12	6.03e-01	-0.086700	7.56e-01
Blood group systems biosynthesis	10	6.36e-01	-0.086400	7.79e-01
Lewis blood group biosynthesis	10	6.36e-01	-0.086400	7.79e-01
Signaling by EGFR	44	3.23e-01	0.086300	5.43e-01
Transport to the Golgi and subsequent modification	145	7.59e-02	-0.085600	2.17e-01
Heparan sulfate/heparin (HS-GAG) metabolism	44	3.27e-01	0.085500	5.46e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	45	3.22e-01	0.085300	5.43e-01
Translesion Synthesis by POLH	16	5.55e-01	0.085200	7.23e-01
O-glycosylation of TSR domain-containing proteins	32	4.08e-01	0.084600	6.12e-01
Major pathway of rRNA processing in the nucleolus and cytosol	138	8.78e-02	0.084400	2.35e-01
Signaling by NODAL	12	6.14e-01	-0.084200	7.65e-01
Negative regulation of FGFR3 signaling	21	5.07e-01	-0.083700	6.94e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	55	2.84e-01	0.083600	5.01e-01
Ribosomal scanning and start codon recognition	45	3.36e-01	0.083000	5.49e-01
Nonhomologous End-Joining (NHEJ)	32	4.17e-01	-0.082900	6.17e-01
Phase I - Functionalization of compounds	58	2.76e-01	0.082700	4.92e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	31	4.26e-01	0.082600	6.26e-01
Mitotic Prometaphase	172	6.24e-02	0.082600	1.98e-01
Regulation of Apoptosis	45	3.39e-01	0.082500	5.51e-01
Platelet sensitization by LDL	15	5.83e-01	0.082000	7.44e-01
Myogenesis	27	4.62e-01	-0.081900	6.58e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	35	4.03e-01	-0.081800	6.08e-01
Transport of vitamins, nucleosides, and related molecules	29	4.47e-01	-0.081700	6.46e-01
Signaling by ROBO receptors	160	7.62e-02	0.081400	2.17e-01
TGF-beta receptor signaling activates SMADs	28	4.58e-01	-0.081100	6.56e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	24	4.92e-01	0.081000	6.79e-01
Trafficking of AMPA receptors	24	4.92e-01	0.081000	6.79e-01
rRNA processing in the nucleus and cytosol	147	9.14e-02	0.080900	2.43e-01
SUMOylation of transcription cofactors	38	3.89e-01	-0.080700	5.90e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	5.54e-01	0.080600	7.22e-01
Purine ribonucleoside monophosphate biosynthesis	12	6.31e-01	-0.080000	7.77e-01
Diseases of metabolism	183	6.38e-02	-0.079700	1.98e-01
DNA Double-Strand Break Repair	123	1.28e-01	0.079700	3.01e-01
GRB2 events in ERBB2 signaling	15	5.94e-01	0.079500	7.49e-01
Gluconeogenesis	25	4.93e-01	-0.079300	6.79e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	3.33e-01	-0.079200	5.48e-01
RAB GEFs exchange GTP for GDP on RABs	83	2.13e-01	0.079100	4.15e-01
Prolonged ERK activation events	13	6.22e-01	-0.079000	7.69e-01
Hh mutants abrogate ligand secretion	48	3.45e-01	0.078800	5.55e-01
Adherens junctions interactions	16	5.85e-01	0.078800	7.44e-01
Activation of NF-kappaB in B cells	59	3.00e-01	0.078000	5.21e-01
Post NMDA receptor activation events	56	3.14e-01	0.077900	5.33e-01
FCERI mediated NF-kB activation	69	2.64e-01	0.077900	4.79e-01
RAF activation	34	4.33e-01	-0.077700	6.33e-01
Signaling by NTRKs	124	1.36e-01	0.077700	3.12e-01
Degradation of AXIN	47	3.60e-01	0.077300	5.60e-01
RUNX2 regulates bone development	25	5.04e-01	0.077300	6.90e-01
M Phase	314	1.91e-02	0.077300	9.54e-02
Thromboxane signalling through TP receptor	18	5.73e-01	0.076800	7.39e-01
Translesion synthesis by REV1	14	6.19e-01	0.076700	7.69e-01
SUMOylation of DNA damage response and repair proteins	63	2.94e-01	-0.076600	5.13e-01
Regulation of RUNX2 expression and activity	60	3.07e-01	0.076400	5.26e-01
Tie2 Signaling	17	5.86e-01	-0.076400	7.44e-01
MAPK family signaling cascades	269	3.20e-02	0.076300	1.32e-01
Gene expression (Transcription)	1079	4.55e-05	-0.074800	8.06e-04
FRS-mediated FGFR4 signaling	15	6.16e-01	-0.074800	7.66e-01
Voltage gated Potassium channels	29	4.86e-01	-0.074700	6.77e-01
Uptake and function of anthrax toxins	10	6.82e-01	0.074700	8.18e-01
Diseases associated with O-glycosylation of proteins	46	3.81e-01	0.074700	5.83e-01
UCH proteinases	76	2.62e-01	0.074500	4.78e-01
Muscle contraction	163	1.02e-01	0.074400	2.58e-01
Chaperone Mediated Autophagy	15	6.18e-01	-0.074400	7.68e-01
Signaling by ERBB2 TMD/JMD mutants	20	5.65e-01	0.074300	7.33e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	5.77e-01	0.074000	7.41e-01
Mitotic Prophase	74	2.72e-01	-0.074000	4.88e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	79	2.56e-01	-0.074000	4.70e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	17	5.98e-01	0.073900	7.51e-01
Neddylation	207	6.78e-02	-0.073900	2.02e-01
TP53 Regulates Transcription of DNA Repair Genes	57	3.36e-01	-0.073800	5.49e-01
activated TAK1 mediates p38 MAPK activation	18	5.88e-01	-0.073700	7.46e-01
Glucagon signaling in metabolic regulation	27	5.08e-01	0.073600	6.94e-01
Early Phase of HIV Life Cycle	13	6.47e-01	0.073400	7.86e-01
RNA Polymerase II Transcription	962	1.69e-04	-0.072700	2.52e-03
ERKs are inactivated	13	6.51e-01	-0.072400	7.90e-01
FOXO-mediated transcription	57	3.45e-01	-0.072400	5.55e-01
Nuclear Envelope (NE) Reassembly	61	3.32e-01	0.072000	5.48e-01
Activation of HOX genes during differentiation	49	3.85e-01	-0.071700	5.85e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	49	3.85e-01	-0.071700	5.85e-01
Nucleobase catabolism	25	5.35e-01	0.071700	7.07e-01
Beta-catenin independent WNT signaling	128	1.63e-01	0.071600	3.53e-01
DNA Damage Recognition in GG-NER	35	4.65e-01	-0.071400	6.58e-01
Regulation of RAS by GAPs	58	3.48e-01	0.071400	5.55e-01
Intracellular signaling by second messengers	273	4.38e-02	0.071200	1.58e-01
Toll Like Receptor 9 (TLR9) Cascade	83	2.63e-01	-0.071100	4.79e-01
RHO GTPases activate KTN1	10	6.98e-01	0.071000	8.28e-01
Nephrin family interactions	19	5.92e-01	-0.071000	7.49e-01
Golgi-to-ER retrograde transport	106	2.11e-01	0.070400	4.13e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	6.88e-01	-0.070000	8.21e-01
G beta:gamma signalling through PLC beta	15	6.39e-01	0.069900	7.80e-01
Presynaptic function of Kainate receptors	15	6.39e-01	0.069900	7.80e-01
ADP signalling through P2Y purinoceptor 12	16	6.32e-01	0.069100	7.77e-01
Stimuli-sensing channels	66	3.33e-01	0.069000	5.48e-01
Activation of NMDA receptors and postsynaptic events	68	3.26e-01	0.069000	5.46e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	46	4.19e-01	0.069000	6.18e-01
Processive synthesis on the C-strand of the telomere	19	6.03e-01	0.068900	7.56e-01
Metabolism of porphyrins	21	5.85e-01	0.068800	7.44e-01
MicroRNA (miRNA) biogenesis	23	5.72e-01	-0.068100	7.39e-01
Defective CFTR causes cystic fibrosis	50	4.05e-01	0.068100	6.10e-01
Hedgehog ligand biogenesis	52	3.96e-01	0.068000	6.00e-01
HIV Infection	200	1.01e-01	-0.067500	2.56e-01
Signaling by ERBB2 in Cancer	24	5.68e-01	0.067400	7.35e-01
Assembly Of The HIV Virion	13	6.74e-01	0.067400	8.12e-01
Nicotinate metabolism	25	5.63e-01	0.066900	7.30e-01
Global Genome Nucleotide Excision Repair (GG-NER)	79	3.05e-01	-0.066800	5.24e-01
Iron uptake and transport	46	4.35e-01	-0.066600	6.34e-01
DNA Damage/Telomere Stress Induced Senescence	27	5.50e-01	0.066500	7.20e-01
Transcriptional regulation by RUNX1	150	1.63e-01	0.066200	3.53e-01
Sema4D in semaphorin signaling	24	5.75e-01	0.066100	7.41e-01
Metabolism of RNA	583	7.07e-03	-0.065900	4.77e-02
SHC-mediated cascade:FGFR1	14	6.70e-01	-0.065800	8.09e-01
Neurotransmitter receptors and postsynaptic signal transmission	139	1.82e-01	0.065600	3.75e-01
Regulation of localization of FOXO transcription factors	12	6.97e-01	0.065000	8.28e-01
Regulated proteolysis of p75NTR	11	7.09e-01	-0.064900	8.35e-01
Carboxyterminal post-translational modifications of tubulin	24	5.83e-01	0.064800	7.44e-01
Visual phototransduction	55	4.09e-01	0.064400	6.12e-01
Regulation of TP53 Expression and Degradation	33	5.24e-01	0.064100	7.03e-01
Ion homeostasis	46	4.54e-01	-0.063900	6.53e-01
Disorders of developmental biology	11	7.14e-01	0.063700	8.38e-01
Loss of function of MECP2 in Rett syndrome	11	7.14e-01	0.063700	8.38e-01
Pervasive developmental disorders	11	7.14e-01	0.063700	8.38e-01
RHO GTPases activate CIT	19	6.31e-01	0.063700	7.77e-01
Signaling by FGFR1 in disease	33	5.28e-01	-0.063600	7.04e-01
Disease	1121	4.55e-04	0.063200	5.50e-03
PIP3 activates AKT signaling	235	9.63e-02	0.063200	2.50e-01
PKA-mediated phosphorylation of CREB	19	6.34e-01	0.063200	7.77e-01
Dual Incision in GG-NER	39	4.96e-01	-0.063100	6.82e-01
ADP signalling through P2Y purinoceptor 1	20	6.26e-01	0.062900	7.72e-01
Ion transport by P-type ATPases	40	4.95e-01	-0.062400	6.82e-01
Deactivation of the beta-catenin transactivating complex	34	5.32e-01	0.061900	7.07e-01
Selective autophagy	52	4.42e-01	-0.061700	6.43e-01
Glutamate and glutamine metabolism	11	7.24e-01	-0.061500	8.45e-01
Downstream signaling events of B Cell Receptor (BCR)	71	3.71e-01	0.061400	5.74e-01
Rap1 signalling	15	6.82e-01	0.061100	8.18e-01
AURKA Activation by TPX2	67	3.88e-01	0.061100	5.88e-01
Membrane binding and targetting of GAG proteins	11	7.27e-01	0.060800	8.45e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	11	7.27e-01	0.060800	8.45e-01
rRNA modification in the nucleus and cytosol	53	4.44e-01	0.060800	6.45e-01
MyD88 dependent cascade initiated on endosome	80	3.49e-01	-0.060700	5.55e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	80	3.49e-01	-0.060700	5.55e-01
CDT1 association with the CDC6:ORC:origin complex	50	4.59e-01	0.060600	6.56e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	41	5.03e-01	-0.060500	6.90e-01
PKMTs methylate histone lysines	37	5.26e-01	-0.060300	7.03e-01
Asparagine N-linked glycosylation	248	1.07e-01	-0.059600	2.69e-01
Unfolded Protein Response (UPR)	84	3.47e-01	-0.059400	5.55e-01
Nuclear Events (kinase and transcription factor activation)	55	4.47e-01	0.059300	6.46e-01
GLI3 is processed to GLI3R by the proteasome	50	4.69e-01	0.059300	6.61e-01
SRP-dependent cotranslational protein targeting to membrane	74	3.80e-01	0.059100	5.83e-01
Activation of kainate receptors upon glutamate binding	23	6.24e-01	0.059100	7.70e-01
Cellular response to hypoxia	64	4.17e-01	0.058700	6.17e-01
Pre-NOTCH Expression and Processing	48	4.82e-01	0.058600	6.74e-01
Integration of energy metabolism	92	3.32e-01	0.058600	5.48e-01
Degradation of GLI2 by the proteasome	50	4.74e-01	0.058600	6.67e-01
Toll-like Receptor Cascades	127	2.56e-01	0.058500	4.70e-01
FGFR1 mutant receptor activation	26	6.06e-01	-0.058400	7.59e-01
Signaling by PDGFRA extracellular domain mutants	12	7.26e-01	0.058400	8.45e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	7.26e-01	0.058400	8.45e-01
ER Quality Control Compartment (ERQC)	17	6.78e-01	-0.058200	8.15e-01
Potassium Channels	68	4.10e-01	-0.057800	6.12e-01
Acyl chain remodelling of PC	18	6.73e-01	0.057500	8.11e-01
Constitutive Signaling by EGFRvIII	15	7.01e-01	-0.057400	8.28e-01
Signaling by EGFRvIII in Cancer	15	7.01e-01	-0.057400	8.28e-01
Regulation of TP53 Activity through Phosphorylation	86	3.59e-01	0.057300	5.60e-01
trans-Golgi Network Vesicle Budding	66	4.22e-01	-0.057200	6.23e-01
Signaling by Leptin	11	7.44e-01	0.057000	8.55e-01
Signaling by Insulin receptor	59	4.51e-01	-0.056800	6.50e-01
Signaling by NOTCH1	64	4.33e-01	0.056700	6.33e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	29	6.01e-01	0.056200	7.54e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	11	7.48e-01	0.056000	8.57e-01
Transcriptional Regulation by VENTX	36	5.63e-01	0.055800	7.30e-01
Signaling by ERBB4	49	5.00e-01	0.055800	6.86e-01
B-WICH complex positively regulates rRNA expression	32	5.86e-01	-0.055600	7.44e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	7.61e-01	0.055600	8.64e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	84	3.80e-01	-0.055400	5.83e-01
Toll Like Receptor 2 (TLR2) Cascade	84	3.80e-01	-0.055400	5.83e-01
Toll Like Receptor TLR1:TLR2 Cascade	84	3.80e-01	-0.055400	5.83e-01
Toll Like Receptor TLR6:TLR2 Cascade	84	3.80e-01	-0.055400	5.83e-01
RNA Polymerase I Transcription Initiation	45	5.24e-01	-0.055000	7.03e-01
GAB1 signalosome	14	7.24e-01	0.054600	8.45e-01
NOTCH4 Intracellular Domain Regulates Transcription	16	7.07e-01	-0.054300	8.34e-01
Fatty acid metabolism	124	2.99e-01	-0.054100	5.20e-01
AKT phosphorylates targets in the nucleus	10	7.69e-01	0.053600	8.69e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	7.29e-01	-0.053600	8.46e-01
Interleukin-1 signaling	85	4.00e-01	0.052800	6.05e-01
Mitotic G2-G2/M phases	169	2.40e-01	0.052500	4.52e-01
Degradation of GLI1 by the proteasome	51	5.22e-01	0.051900	7.03e-01
GABA receptor activation	40	5.74e-01	-0.051400	7.40e-01
Clathrin-mediated endocytosis	121	3.30e-01	0.051300	5.48e-01
SLC transporter disorders	62	4.89e-01	-0.050900	6.77e-01
SHC-mediated cascade:FGFR3	12	7.60e-01	-0.050900	8.64e-01
Signaling by TGF-beta Receptor Complex	67	4.73e-01	-0.050800	6.66e-01
Thrombin signalling through proteinase activated receptors (PARs)	26	6.54e-01	0.050800	7.93e-01
Epigenetic regulation of gene expression	84	4.22e-01	-0.050700	6.23e-01
Transcriptional Regulation by MECP2	48	5.44e-01	-0.050700	7.15e-01
DNA Damage Bypass	40	5.80e-01	0.050700	7.44e-01
Transcriptional Regulation by E2F6	33	6.15e-01	0.050600	7.66e-01
ABC transporters in lipid homeostasis	13	7.53e-01	-0.050400	8.59e-01
Assembly of active LPL and LIPC lipase complexes	10	7.84e-01	0.050100	8.80e-01
Interleukin-12 signaling	40	5.84e-01	0.050000	7.44e-01
Cytosolic sensors of pathogen-associated DNA	56	5.19e-01	0.049900	7.01e-01
Generic Transcription Pathway	849	1.51e-02	-0.049800	8.30e-02
Signaling by NTRK1 (TRKA)	105	3.79e-01	0.049800	5.83e-01
Signaling by NOTCH4	72	4.66e-01	0.049700	6.59e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	14	7.48e-01	-0.049700	8.57e-01
Influenza Viral RNA Transcription and Replication	93	4.10e-01	0.049500	6.12e-01
Downstream signaling of activated FGFR2	22	6.88e-01	-0.049500	8.21e-01
Spry regulation of FGF signaling	14	7.50e-01	-0.049200	8.57e-01
COPI-independent Golgi-to-ER retrograde traffic	30	6.43e-01	-0.048900	7.83e-01
Inositol phosphate metabolism	44	5.76e-01	0.048700	7.41e-01
SHC-mediated cascade:FGFR4	13	7.61e-01	0.048700	8.64e-01
Cellular Senescence	118	3.63e-01	0.048600	5.64e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	5.71e-01	0.048400	7.38e-01
Diseases of signal transduction by growth factor receptors and second messengers	337	1.31e-01	0.048100	3.04e-01
HCMV Infection	73	4.79e-01	-0.048000	6.70e-01
Cardiac conduction	102	4.04e-01	0.047900	6.08e-01
Transcriptional regulation of white adipocyte differentiation	79	4.62e-01	-0.047900	6.58e-01
G2/M Transition	167	2.89e-01	0.047700	5.07e-01
Post-translational modification: synthesis of GPI-anchored proteins	52	5.53e-01	-0.047600	7.22e-01
Metabolism	1579	2.15e-03	-0.047600	1.85e-02
Negative regulation of FGFR2 signaling	24	6.88e-01	-0.047400	8.21e-01
Bile acid and bile salt metabolism	25	6.82e-01	0.047300	8.18e-01
Signaling by ERBB2 KD Mutants	23	6.95e-01	0.047200	8.27e-01
Regulation of MECP2 expression and activity	28	6.67e-01	-0.047000	8.06e-01
NRIF signals cell death from the nucleus	14	7.62e-01	-0.046700	8.64e-01
Fatty acyl-CoA biosynthesis	23	6.98e-01	0.046700	8.28e-01
Nuclear Envelope Breakdown	46	5.85e-01	-0.046600	7.44e-01
IRS-related events triggered by IGF1R	38	6.22e-01	-0.046200	7.69e-01
Nuclear Receptor transcription pathway	41	6.09e-01	-0.046200	7.61e-01
Lysosome Vesicle Biogenesis	30	6.63e-01	0.045900	8.02e-01
Biological oxidations	122	3.84e-01	-0.045800	5.85e-01
Signaling by FGFR2 in disease	34	6.47e-01	-0.045400	7.86e-01
Signaling by FGFR3 fusions in cancer	10	8.05e-01	-0.045100	8.95e-01
Metalloprotease DUBs	18	7.41e-01	-0.045000	8.55e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	70	5.17e-01	0.044900	6.99e-01
Glycogen breakdown (glycogenolysis)	14	7.74e-01	0.044300	8.74e-01
Aggrephagy	18	7.49e-01	0.043600	8.57e-01
Apoptotic cleavage of cellular proteins	29	6.86e-01	0.043400	8.21e-01
Signaling by FGFR4	32	6.72e-01	-0.043200	8.11e-01
Activated NTRK2 signals through FRS2 and FRS3	11	8.05e-01	-0.043100	8.95e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	22	7.29e-01	0.042700	8.46e-01
NOTCH1 Intracellular Domain Regulates Transcription	41	6.37e-01	-0.042700	7.79e-01
RNA Polymerase I Promoter Clearance	48	6.10e-01	-0.042600	7.61e-01
SHC1 events in EGFR signaling	11	8.08e-01	0.042400	8.96e-01
Metabolic disorders of biological oxidation enzymes	22	7.31e-01	-0.042400	8.48e-01
Ca2+ pathway	53	5.95e-01	-0.042200	7.50e-01
Cell-cell junction organization	30	6.95e-01	0.041400	8.27e-01
PI-3K cascade:FGFR2	15	7.82e-01	-0.041400	8.80e-01
Extra-nuclear estrogen signaling	60	5.80e-01	0.041300	7.44e-01
Neuronal System	283	2.40e-01	0.040800	4.52e-01
Toll Like Receptor 4 (TLR4) Cascade	111	4.65e-01	0.040200	6.58e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	7.44e-01	0.040200	8.55e-01
Signaling by cytosolic FGFR1 fusion mutants	18	7.70e-01	-0.039800	8.69e-01
Nucleobase biosynthesis	15	7.89e-01	-0.039800	8.82e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	11	8.20e-01	0.039700	9.05e-01
Synthesis of PC	22	7.49e-01	0.039400	8.57e-01
E2F mediated regulation of DNA replication	21	7.55e-01	-0.039300	8.59e-01
Budding and maturation of HIV virion	24	7.40e-01	-0.039100	8.55e-01
Vasopressin regulates renal water homeostasis via Aquaporins	33	7.01e-01	-0.038700	8.28e-01
FGFR2 mutant receptor activation	24	7.43e-01	-0.038700	8.55e-01
Pausing and recovery of Tat-mediated HIV elongation	26	7.35e-01	0.038400	8.51e-01
Tat-mediated HIV elongation arrest and recovery	26	7.35e-01	0.038400	8.51e-01
Regulation of TP53 Degradation	32	7.08e-01	0.038200	8.35e-01
Signaling by FGFR2	59	6.12e-01	-0.038200	7.63e-01
RNA Polymerase I Transcription	49	6.46e-01	-0.038000	7.86e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	31	7.16e-01	0.037800	8.38e-01
Estrogen-dependent gene expression	81	5.62e-01	-0.037300	7.30e-01
Influenza Infection	108	5.08e-01	0.037000	6.94e-01
Metabolism of proteins	1522	1.90e-02	-0.036900	9.54e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	23	7.61e-01	0.036600	8.64e-01
Cellular responses to stress	416	2.05e-01	-0.036400	4.05e-01
Cleavage of the damaged purine	11	8.35e-01	0.036400	9.16e-01
Depurination	11	8.35e-01	0.036400	9.16e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	8.35e-01	0.036400	9.16e-01
Reproduction	58	6.34e-01	0.036200	7.77e-01
ESR-mediated signaling	138	4.64e-01	-0.036200	6.58e-01
Regulation of TP53 Activity through Methylation	15	8.10e-01	-0.035800	8.97e-01
Metabolism of fat-soluble vitamins	29	7.39e-01	0.035700	8.55e-01
Insulin receptor signalling cascade	41	6.93e-01	-0.035700	8.26e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	7.53e-01	0.035600	8.59e-01
Transmission across Chemical Synapses	183	4.11e-01	0.035300	6.12e-01
Signaling by BMP	25	7.63e-01	0.034900	8.64e-01
Ub-specific processing proteases	148	4.67e-01	-0.034800	6.59e-01
Acyl chain remodelling of PE	16	8.11e-01	-0.034500	8.98e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	71	6.22e-01	0.033900	7.69e-01
Incretin synthesis, secretion, and inactivation	11	8.47e-01	-0.033600	9.21e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	11	8.47e-01	-0.033600	9.21e-01
Acyl chain remodelling of PG	10	8.54e-01	0.033600	9.26e-01
Chaperonin-mediated protein folding	77	6.22e-01	-0.032500	7.69e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	24	7.85e-01	-0.032100	8.80e-01
Potential therapeutics for SARS	35	7.46e-01	0.031600	8.57e-01
Anchoring of the basal body to the plasma membrane	89	6.10e-01	-0.031300	7.61e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	7.87e-01	-0.031300	8.80e-01
GRB2 events in EGFR signaling	10	8.64e-01	-0.031300	9.32e-01
Protein folding	83	6.23e-01	-0.031200	7.70e-01
Signaling by Nuclear Receptors	194	4.58e-01	-0.031000	6.56e-01
Degradation of beta-catenin by the destruction complex	73	6.52e-01	0.030600	7.90e-01
PTEN Regulation	128	5.52e-01	0.030500	7.22e-01
Regulation of TP53 Activity	148	5.24e-01	0.030400	7.03e-01
Signaling by FGFR1	40	7.41e-01	-0.030200	8.55e-01
SLC-mediated transmembrane transport	158	5.14e-01	0.030100	6.97e-01
Cellular responses to external stimuli	420	2.98e-01	-0.029800	5.18e-01
FGFR2 alternative splicing	23	8.06e-01	-0.029600	8.95e-01
Regulation of PTEN gene transcription	57	7.00e-01	-0.029500	8.28e-01
Vesicle-mediated transport	555	2.42e-01	0.029300	4.54e-01
SUMOylation of intracellular receptors	24	8.06e-01	-0.029000	8.95e-01
Synthesis of PA	23	8.10e-01	-0.029000	8.97e-01
Signalling to ERKs	31	7.84e-01	0.028500	8.80e-01
Meiotic recombination	21	8.26e-01	0.027800	9.10e-01
Glutamate Neurotransmitter Release Cycle	18	8.41e-01	-0.027400	9.19e-01
Loss of Nlp from mitotic centrosomes	64	7.05e-01	0.027400	8.32e-01
Loss of proteins required for interphase microtubule organization from the centrosome	64	7.05e-01	0.027400	8.32e-01
Ras activation upon Ca2+ influx through NMDA receptor	17	8.45e-01	0.027300	9.21e-01
Metabolism of amino acids and derivatives	254	4.63e-01	-0.026900	6.58e-01
Activation of GABAB receptors	31	7.97e-01	0.026700	8.89e-01
GABA B receptor activation	31	7.97e-01	0.026700	8.89e-01
ABC-family proteins mediated transport	81	6.80e-01	0.026500	8.17e-01
ISG15 antiviral mechanism	59	7.26e-01	0.026400	8.45e-01
Host Interactions of HIV factors	109	6.40e-01	0.026000	7.81e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	34	7.94e-01	0.025900	8.87e-01
Apoptotic execution phase	37	7.87e-01	0.025700	8.80e-01
Netrin-1 signaling	47	7.64e-01	0.025300	8.65e-01
IGF1R signaling cascade	39	7.87e-01	-0.025000	8.80e-01
Frs2-mediated activation	11	8.86e-01	-0.024900	9.48e-01
Metabolism of steroids	108	6.55e-01	-0.024900	7.93e-01
Late endosomal microautophagy	26	8.26e-01	-0.024900	9.10e-01
Signaling by FGFR4 in disease	11	8.87e-01	0.024800	9.48e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	8.44e-01	0.024800	9.20e-01
Antigen processing: Ubiquitination & Proteasome degradation	274	4.88e-01	-0.024400	6.77e-01
Translesion synthesis by POLI	15	8.71e-01	0.024200	9.38e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	8.52e-01	-0.024100	9.25e-01
Platelet calcium homeostasis	24	8.39e-01	0.023900	9.19e-01
HDACs deacetylate histones	29	8.25e-01	0.023700	9.10e-01
Negative regulation of FGFR4 signaling	22	8.50e-01	-0.023400	9.23e-01
Downstream signaling of activated FGFR4	20	8.57e-01	-0.023200	9.27e-01
Toll Like Receptor 3 (TLR3) Cascade	85	7.15e-01	-0.023000	8.38e-01
Mismatch Repair	15	8.82e-01	-0.022000	9.47e-01
Metal ion SLC transporters	20	8.69e-01	0.021300	9.36e-01
Transcriptional regulation of pluripotent stem cells	16	8.84e-01	0.021100	9.47e-01
Metabolism of carbohydrates	233	5.84e-01	0.020900	7.44e-01
IRS-mediated signalling	36	8.29e-01	-0.020800	9.12e-01
Fanconi Anemia Pathway	31	8.44e-01	-0.020400	9.20e-01
Gastrin-CREB signalling pathway via PKC and MAPK	15	8.91e-01	-0.020400	9.50e-01
Transcriptional Regulation by TP53	330	5.34e-01	-0.020000	7.07e-01
RMTs methylate histone arginines	27	8.58e-01	-0.019900	9.27e-01
Signaling by TGFB family members	92	7.43e-01	-0.019800	8.55e-01
MyD88-independent TLR4 cascade	87	7.54e-01	-0.019500	8.59e-01
TRIF(TICAM1)-mediated TLR4 signaling	87	7.54e-01	-0.019500	8.59e-01
Removal of the Flap Intermediate from the C-strand	17	8.90e-01	0.019400	9.50e-01
TP53 Regulates Transcription of Cell Death Genes	37	8.38e-01	0.019400	9.19e-01
RNA Polymerase III Transcription Termination	23	8.72e-01	-0.019400	9.39e-01
Purine salvage	12	9.08e-01	0.019300	9.57e-01
MET activates RAS signaling	10	9.17e-01	0.019100	9.61e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	17	8.92e-01	-0.019100	9.50e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	17	8.92e-01	-0.019100	9.50e-01
Signaling by Hedgehog	120	7.19e-01	0.019000	8.42e-01
ABC transporter disorders	58	8.05e-01	0.018700	8.95e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	8.98e-01	-0.018600	9.52e-01
IRE1alpha activates chaperones	48	8.26e-01	-0.018300	9.10e-01
G-protein activation	17	8.97e-01	0.018200	9.52e-01
Cargo recognition for clathrin-mediated endocytosis	83	7.76e-01	0.018100	8.75e-01
Centrosome maturation	76	7.86e-01	0.018000	8.80e-01
Recruitment of mitotic centrosome proteins and complexes	76	7.86e-01	0.018000	8.80e-01
Meiotic synapsis	27	8.76e-01	0.017400	9.42e-01
Class I MHC mediated antigen processing & presentation	321	5.94e-01	0.017400	7.49e-01
Disorders of transmembrane transporters	120	7.44e-01	-0.017300	8.55e-01
G beta:gamma signalling through BTK	13	9.15e-01	0.017000	9.61e-01
SUMOylation of DNA replication proteins	38	8.57e-01	-0.016900	9.27e-01
Membrane Trafficking	527	5.24e-01	0.016300	7.03e-01
CDC6 association with the ORC:origin complex	11	9.26e-01	-0.016200	9.66e-01
Peptide hormone metabolism	51	8.42e-01	-0.016100	9.20e-01
Post-translational protein modification	1086	3.82e-01	-0.016000	5.84e-01
Insulin processing	21	9.00e-01	0.015900	9.52e-01
Inhibition of DNA recombination at telomere	20	9.04e-01	0.015600	9.54e-01
Calnexin/calreticulin cycle	22	9.00e-01	-0.015400	9.52e-01
Regulation of PLK1 Activity at G2/M Transition	80	8.12e-01	-0.015400	8.98e-01
CD209 (DC-SIGN) signaling	18	9.11e-01	0.015300	9.58e-01
Aquaporin-mediated transport	36	8.77e-01	-0.015000	9.42e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	25	8.97e-01	0.015000	9.52e-01
Synthesis of bile acids and bile salts	23	9.03e-01	0.014700	9.54e-01
DNA Repair	262	6.85e-01	-0.014600	8.20e-01
Receptor-type tyrosine-protein phosphatases	12	9.31e-01	0.014500	9.69e-01
Signaling by FGFR	70	8.41e-01	-0.013900	9.20e-01
Amino acid transport across the plasma membrane	24	9.10e-01	0.013400	9.57e-01
Interleukin-6 family signaling	19	9.21e-01	0.013200	9.65e-01
Signaling by Activin	12	9.37e-01	0.013100	9.73e-01
RAS processing	18	9.24e-01	-0.013000	9.65e-01
Positive epigenetic regulation of rRNA expression	45	8.84e-01	0.012600	9.47e-01
Hedgehog 'off' state	90	8.40e-01	0.012300	9.19e-01
Translesion synthesis by POLK	15	9.35e-01	0.012200	9.72e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	9.42e-01	-0.011700	9.77e-01
RHO GTPases activate PAKs	21	9.27e-01	-0.011600	9.66e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	9.45e-01	0.010600	9.79e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	40	9.08e-01	-0.010500	9.57e-01
Diseases of glycosylation	112	8.48e-01	0.010500	9.22e-01
HIV elongation arrest and recovery	28	9.24e-01	-0.010500	9.65e-01
Pausing and recovery of HIV elongation	28	9.24e-01	-0.010500	9.65e-01
PIWI-interacting RNA (piRNA) biogenesis	19	9.37e-01	0.010500	9.73e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	50	9.00e-01	0.010300	9.52e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	50	9.00e-01	0.010300	9.52e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	50	9.00e-01	0.010300	9.52e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	50	9.00e-01	0.010300	9.52e-01
Signaling by NOTCH1 in Cancer	50	9.00e-01	0.010300	9.52e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	8.78e-01	-0.010200	9.42e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	37	9.23e-01	0.009220	9.65e-01
Metabolism of lipids	564	7.11e-01	-0.009200	8.37e-01
DNA Double Strand Break Response	38	9.22e-01	0.009190	9.65e-01
Phospholipase C-mediated cascade; FGFR2	10	9.62e-01	-0.008600	9.88e-01
PI3K Cascade	32	9.39e-01	0.007810	9.74e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	9.60e-01	0.007770	9.87e-01
Acetylcholine Neurotransmitter Release Cycle	11	9.65e-01	-0.007630	9.88e-01
MAPK6/MAPK4 signaling	77	9.10e-01	0.007470	9.57e-01
Signaling by WNT	225	8.55e-01	-0.007100	9.26e-01
Hyaluronan uptake and degradation	12	9.66e-01	0.007040	9.88e-01
FGFR2 ligand binding and activation	11	9.68e-01	0.006890	9.88e-01
Pre-NOTCH Transcription and Translation	33	9.48e-01	0.006520	9.81e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	30	9.51e-01	-0.006480	9.81e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	9.60e-01	0.006470	9.87e-01
IRF3-mediated induction of type I IFN	10	9.72e-01	-0.006450	9.88e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	9.69e-01	0.006430	9.88e-01
RUNX3 regulates NOTCH signaling	14	9.68e-01	0.006200	9.88e-01
Notch-HLH transcription pathway	25	9.59e-01	-0.005920	9.87e-01
Opioid Signalling	75	9.30e-01	-0.005880	9.69e-01
Acyl chain remodelling of PS	13	9.71e-01	0.005840	9.88e-01
Signaling by EGFR in Cancer	20	9.65e-01	0.005640	9.88e-01
Ion channel transport	122	9.15e-01	-0.005590	9.61e-01
Synthesis of PIPs at the plasma membrane	50	9.48e-01	-0.005370	9.81e-01
Signaling by FGFR in disease	54	9.49e-01	-0.005050	9.81e-01
RNA Polymerase III Chain Elongation	18	9.71e-01	-0.004980	9.88e-01
Transport of small molecules	498	8.59e-01	0.004680	9.28e-01
Response of Mtb to phagocytosis	19	9.76e-01	0.004050	9.90e-01
Regulation of beta-cell development	19	9.77e-01	-0.003880	9.90e-01
Assembly and cell surface presentation of NMDA receptors	22	9.79e-01	0.003270	9.90e-01
Triglyceride metabolism	23	9.79e-01	-0.003140	9.90e-01
SUMOylation	145	9.51e-01	-0.002970	9.81e-01
Meiosis	46	9.73e-01	0.002910	9.88e-01
PI Metabolism	78	9.68e-01	-0.002650	9.88e-01
Glycerophospholipid biosynthesis	92	9.66e-01	0.002560	9.88e-01
SUMO E3 ligases SUMOylate target proteins	139	9.60e-01	0.002490	9.87e-01
TCF dependent signaling in response to WNT	144	9.59e-01	0.002460	9.87e-01
Prostacyclin signalling through prostacyclin receptor	14	9.88e-01	0.002310	9.97e-01
PPARA activates gene expression	106	9.68e-01	0.002260	9.88e-01
XBP1(S) activates chaperone genes	46	9.79e-01	0.002210	9.90e-01
Suppression of phagosomal maturation	10	9.90e-01	-0.002180	9.97e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	9.91e-01	-0.002050	9.97e-01
Oxidative Stress Induced Senescence	59	9.81e-01	-0.001840	9.91e-01
Phospholipid metabolism	169	9.69e-01	0.001720	9.88e-01
Glutathione conjugation	30	9.87e-01	0.001680	9.97e-01
Signaling by NOTCH2	25	9.92e-01	-0.001190	9.97e-01
Deubiquitination	222	9.77e-01	-0.001120	9.90e-01
Recruitment of NuMA to mitotic centrosomes	75	9.88e-01	0.000982	9.97e-01
Regulation of lipid metabolism by PPARalpha	108	9.89e-01	-0.000759	9.97e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	30	9.94e-01	-0.000752	9.99e-01
SHC-mediated cascade:FGFR2	15	9.97e-01	0.000598	9.99e-01
Signaling by ERBB2 ECD mutants	15	9.97e-01	0.000475	9.99e-01
Tight junction interactions	12	9.98e-01	-0.000422	9.99e-01
Negative regulation of MAPK pathway	40	9.97e-01	0.000388	9.99e-01
PI-3K cascade:FGFR4	13	9.99e-01	0.000289	9.99e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	166	9.95e-01	0.000261	9.99e-01

---

Detailed Gene set reports

FCGR activation

FCGR activation

	353
set	FCGR activation
setSize	11
pANOVA	3.45e-07
s.dist	0.887
p.adjustANOVA	1.09e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FGR	7053.0
FCGR1A	7006.5
FCGR3A	6979.5
FCGR2A	6892.5
HCK	6861.0
CD247	6858.0
LYN	6800.0
FYN	6628.0
SYK	6507.0
SRC	5659.0
YES1	2437.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FGR	7053.0
FCGR1A	7006.5
FCGR3A	6979.5
FCGR2A	6892.5
HCK	6861.0
CD247	6858.0
LYN	6800.0
FYN	6628.0
SYK	6507.0
SRC	5659.0
YES1	2437.0

---

PD-1 signaling

PD-1 signaling

	756
set	PD-1 signaling
setSize	13
pANOVA	8.38e-07
s.dist	0.789
p.adjustANOVA	2.47e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD274	7030.0
PDCD1LG2	6949.0
LCK	6930.0
PTPN6	6928.0
CD247	6858.0
CD4	6448.0
PDCD1	6400.0
CD3E	6144.0
TRAC	6017.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
CSK	4526.0
PTPN11	-1824.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD274	7030.0
PDCD1LG2	6949.0
LCK	6930.0
PTPN6	6928.0
CD247	6858.0
CD4	6448.0
PDCD1	6400.0
CD3E	6144.0
TRAC	6017.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
CSK	4526.0
PTPN11	-1824.0

---

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

	503
set	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
setSize	49
pANOVA	2.04e-20
s.dist	0.764
p.adjustANOVA	9.05e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LAIR1	7033.5
LAIR2	7033.5
CD40	7029.0
SIGLEC1	7019.0
FCGR1A	7006.5
ITGAL	6995.0
FCGR3A	6979.5
CD300LD	6971.5
CD300LF	6971.5
ICAM1	6966.0
FCGR2B	6892.5
CD300A	6884.5
CD300C	6884.5
CD200R1	6871.5
CD247	6858.0
PILRA	6777.5
PILRB	6777.5
SLAMF6	6774.0
B2M	6748.0
ITGB2	6741.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LAIR1	7033.5
LAIR2	7033.5
CD40	7029.0
SIGLEC1	7019.0
FCGR1A	7006.5
ITGAL	6995.0
FCGR3A	6979.5
CD300LD	6971.5
CD300LF	6971.5
ICAM1	6966.0
FCGR2B	6892.5
CD300A	6884.5
CD300C	6884.5
CD200R1	6871.5
CD247	6858.0
PILRA	6777.5
PILRB	6777.5
SLAMF6	6774.0
B2M	6748.0
ITGB2	6741.0
VCAM1	6715.0
SELL	6643.0
CD8A	6612.0
ITGB7	6608.0
CD300LB	6598.0
TREM2	6589.0
TYROBP	6545.0
KLRK1	6516.0
SLAMF7	6344.0
CD3E	6144.0
CD22	6104.0
TRAC	6017.0
SIGLEC10	5933.5
SIGLEC11	5933.5
CD226	5606.0
NPDC1	5505.0
C3	5368.0
IFITM1	5347.0
CD96	5297.0
CD200	4905.0
COLEC12	4796.0
CD34	4495.0
CD1D	3901.0
CD81	3060.0
CD300LG	2607.0
ITGB1	-376.0
CXADR	-720.0
OSCAR	-2401.0
ITGA4	-4611.0

---

Interleukin-10 signaling

Interleukin-10 signaling

	538
set	Interleukin-10 signaling
setSize	26
pANOVA	1.39e-10
s.dist	0.727
p.adjustANOVA	8.01e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCR2	7045.0
CXCL10	7043.0
ICAM1	6966.0
CCL2	6937.0
TNFRSF1B	6834.0
IL10RA	6825.0
PTAFR	6782.0
TNF	6561.0
CD80	6440.0
CCL5	6422.0
TIMP1	6411.0
TNFRSF1A	6327.0
CSF1	6303.0
IL10RB	6238.5
LIF	6134.0
IL1R1	5770.0
CD86	5717.0
CCL22	5558.0
IL18	5516.0
IL12B	5394.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCR2	7045.0
CXCL10	7043.0
ICAM1	6966.0
CCL2	6937.0
TNFRSF1B	6834.0
IL10RA	6825.0
PTAFR	6782.0
TNF	6561.0
CD80	6440.0
CCL5	6422.0
TIMP1	6411.0
TNFRSF1A	6327.0
CSF1	6303.0
IL10RB	6238.5
LIF	6134.0
IL1R1	5770.0
CD86	5717.0
CCL22	5558.0
IL18	5516.0
IL12B	5394.0
PTGS2	5317.0
TYK2	3887.0
STAT3	3834.0
IL12A	3016.0
IL1R2	-1599.0
JAK1	-4324.0

---

Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

	798
set	Phosphorylation of CD3 and TCR zeta chains
setSize	12
pANOVA	1.65e-05
s.dist	0.718
p.adjustANOVA	0.000343

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	6930.0
CD247	6858.0
PTPRJ	6771.0
CD4	6448.0
PTPRC	6331.0
CD3E	6144.0
TRAC	6017.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
PTPN22	5331.0
CSK	4526.0
PAG1	-4193.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	6930.0
CD247	6858.0
PTPRJ	6771.0
CD4	6448.0
PTPRC	6331.0
CD3E	6144.0
TRAC	6017.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
PTPN22	5331.0
CSK	4526.0
PAG1	-4193.0

---

Interferon alpha/beta signaling

Interferon alpha/beta signaling

	533
set	Interferon alpha/beta signaling
setSize	42
pANOVA	2.85e-15
s.dist	0.704
p.adjustANOVA	4.2e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFIT3	7065.0
RSAD2	7057.0
OAS1	7054.0
SOCS1	7052.0
IRF1	7048.0
MX1	7047.0
XAF1	7040.0
OAS2	7035.0
STAT1	7016.0
OAS3	6999.0
IRF7	6974.0
SAMHD1	6963.0
PTPN6	6928.0
USP18	6889.5
PSMB8	6882.0
OASL	6867.0
ADAR	6838.0
IRF5	6827.0
STAT2	6788.0
BST2	6738.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFIT3	7065.0
RSAD2	7057.0
OAS1	7054.0
SOCS1	7052.0
IRF1	7048.0
MX1	7047.0
XAF1	7040.0
OAS2	7035.0
STAT1	7016.0
OAS3	6999.0
IRF7	6974.0
SAMHD1	6963.0
PTPN6	6928.0
USP18	6889.5
PSMB8	6882.0
OASL	6867.0
ADAR	6838.0
IRF5	6827.0
STAT2	6788.0
BST2	6738.0
SOCS3	6701.0
IFIT2	6668.0
EGR1	6197.0
IFNAR2	6193.0
RNASEL	6117.0
IFI35	6107.0
IFI27	5553.0
IRF9	5547.0
IRF4	5379.0
IFITM1	5347.0
IFITM2	5347.0
IFITM3	5347.0
ISG20	3969.0
TYK2	3887.0
IRF2	3149.0
PTPN1	2632.0
IFNAR1	1822.0
IRF3	1422.0
IP6K2	-654.0
PTPN11	-1824.0
ABCE1	-4317.0
JAK1	-4324.0

---

Signal regulatory protein family interactions

Signal regulatory protein family interactions

	1040
set	Signal regulatory protein family interactions
setSize	13
pANOVA	2.74e-05
s.dist	0.672
p.adjustANOVA	0.000519

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIRPA	7073.5
SIRPB1	7073.5
SIRPG	7073.5
PTPN6	6928.0
FYB	6850.0
PTK2B	6781.0
TYROBP	6545.0
SKAP2	6186.0
SRC	5659.0
GRB2	4408.0
CD47	2674.0
PTK2	-1355.0
PTPN11	-1824.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIRPA	7073.5
SIRPB1	7073.5
SIRPG	7073.5
PTPN6	6928.0
FYB	6850.0
PTK2B	6781.0
TYROBP	6545.0
SKAP2	6186.0
SRC	5659.0
GRB2	4408.0
CD47	2674.0
PTK2	-1355.0
PTPN11	-1824.0

---

Generation of second messenger molecules

Generation of second messenger molecules

	435
set	Generation of second messenger molecules
setSize	24
pANOVA	4.35e-08
s.dist	0.646
p.adjustANOVA	1.6e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	6930.0
ITK	6866.0
CD247	6858.0
FYB	6850.0
LCP2	6729.0
PLCG2	6686.0
EVL	6662.0
WAS	6575.0
CD4	6448.0
GRAP2	6341.0
CD3E	6144.0
TRAC	6017.0
ZAP70	5873.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
LAT	5744.0
CD101	5712.0
PAK3	5485.0
VASP	5207.0
PLCG1	2357.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	6930.0
ITK	6866.0
CD247	6858.0
FYB	6850.0
LCP2	6729.0
PLCG2	6686.0
EVL	6662.0
WAS	6575.0
CD4	6448.0
GRAP2	6341.0
CD3E	6144.0
TRAC	6017.0
ZAP70	5873.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
LAT	5744.0
CD101	5712.0
PAK3	5485.0
VASP	5207.0
PLCG1	2357.0
NCK1	128.0
PAK2	-776.0
ENAH	-1871.0
PAK1	-4454.0

---

Other interleukin signaling

Other interleukin signaling

	749
set	Other interleukin signaling
setSize	18
pANOVA	3.59e-06
s.dist	0.631
p.adjustANOVA	9.53e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSF3R	7046.0
CSF1R	6582.0
STX3	6501.0
CD4	6448.0
CSF1	6303.0
IL10RB	6238.5
IL16	6184.0
IL34	6180.0
CASP3	6024.0
STX1A	5657.0
SDC1	5567.0
STX4	5119.0
STXBP2	4503.0
TYK2	3887.0
TXLNA	2937.0
VAMP2	2119.0
PTPRZ1	906.0
JAK1	-4324.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSF3R	7046.0
CSF1R	6582.0
STX3	6501.0
CD4	6448.0
CSF1	6303.0
IL10RB	6238.5
IL16	6184.0
IL34	6180.0
CASP3	6024.0
STX1A	5657.0
SDC1	5567.0
STX4	5119.0
STXBP2	4503.0
TYK2	3887.0
TXLNA	2937.0
VAMP2	2119.0
PTPRZ1	906.0
JAK1	-4324.0

---

Interleukin-2 signaling

Interleukin-2 signaling

	544
set	Interleukin-2 signaling
setSize	10
pANOVA	7e-04
s.dist	0.619
p.adjustANOVA	0.00775

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL2RB	7014
LCK	6930
PTK2B	6781
SYK	6507
IL2RA	6221
JAK3	5830
SHC1	5628
STAT5A	3158
STAT5B	2107
JAK1	-4324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL2RB	7014
LCK	6930
PTK2B	6781
SYK	6507
IL2RA	6221
JAK3	5830
SHC1	5628
STAT5A	3158
STAT5B	2107
JAK1	-4324

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	376
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.000894
s.dist	-0.607
p.adjustANOVA	0.00943

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCT4	-5656
CCT7	-5364
CCT3	-4888
TCP1	-4771
CCT5	-4506
CCT6A	-4195
CCT8	-4004
CCT6B	-3134
CCT2	-1005
ACTB	3427

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCT4	-5656
CCT7	-5364
CCT3	-4888
TCP1	-4771
CCT5	-4506
CCT6A	-4195
CCT8	-4004
CCT6B	-3134
CCT2	-1005
ACTB	3427

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	218
set	Crosslinking of collagen fibrils
setSize	10
pANOVA	0.00198
s.dist	0.565
p.adjustANOVA	0.0173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	6749
BMP1	5821
LOXL1	5716
LOX	5342
PXDN	5032
LOXL2	4742
PCOLCE	4676
TLL1	3591
LOXL4	3126
TLL2	-2473

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	6749
BMP1	5821
LOXL1	5716
LOX	5342
PXDN	5032
LOXL2	4742
PCOLCE	4676
TLL1	3591
LOXL4	3126
TLL2	-2473

---

BBSome-mediated cargo-targeting to cilium

BBSome-mediated cargo-targeting to cilium

	99
set	BBSome-mediated cargo-targeting to cilium
setSize	20
pANOVA	1.38e-05
s.dist	-0.562
p.adjustANOVA	0.000295

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MKKS	-5884.0
CCT4	-5656.0
MCHR1	-5519.0
TTC8	-5192.0
BBS10	-5038.0
LZTFL1	-4978.0
CCT3	-4888.0
TCP1	-4771.0
CCT5	-4506.0
BBS4	-4148.0
CCT8	-4004.0
BBS7	-3818.0
BBS9	-3051.0
ARL6	-2050.0
BBS2	-1567.0
CCT2	-1005.0
BBS5	-647.5
RAB3IP	728.5
BBS1	1202.5
SMO	2537.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MKKS	-5884.0
CCT4	-5656.0
MCHR1	-5519.0
TTC8	-5192.0
BBS10	-5038.0
LZTFL1	-4978.0
CCT3	-4888.0
TCP1	-4771.0
CCT5	-4506.0
BBS4	-4148.0
CCT8	-4004.0
BBS7	-3818.0
BBS9	-3051.0
ARL6	-2050.0
BBS2	-1567.0
CCT2	-1005.0
BBS5	-647.5
RAB3IP	728.5
BBS1	1202.5
SMO	2537.0

---

Dectin-2 family

Dectin-2 family

	250
set	Dectin-2 family
setSize	10
pANOVA	0.00214
s.dist	0.561
p.adjustANOVA	0.0185

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLEC4A	7069
LYN	6800
PLCG2	6686
FYN	6628
SYK	6507
CLEC6A	5295
MUC19	5156
FCER1G	2052
MUC1	1200
MUC4	-5343

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLEC4A	7069
LYN	6800
PLCG2	6686
FYN	6628
SYK	6507
CLEC6A	5295
MUC19	5156
FCER1G	2052
MUC1	1200
MUC4	-5343

---

Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)

	184
set	Citric acid cycle (TCA cycle)
setSize	21
pANOVA	9.19e-06
s.dist	-0.559
p.adjustANOVA	0.00021

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDH2	-5681
FH	-5463
SDHC	-5379
FAHD1	-5113
SDHA	-5058
SUCLG2	-5020
ME3	-4862
ACO2	-4735
SDHD	-4536
DLD	-4155
OGDH	-3792
IDH3B	-3598
IDH3A	-3096
MDH2	-2790
SUCLA2	-2754
SDHB	-2550
DLST	-2432
SUCLG1	-1636
IDH3G	-783
CS	2326

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDH2	-5681
FH	-5463
SDHC	-5379
FAHD1	-5113
SDHA	-5058
SUCLG2	-5020
ME3	-4862
ACO2	-4735
SDHD	-4536
DLD	-4155
OGDH	-3792
IDH3B	-3598
IDH3A	-3096
MDH2	-2790
SUCLA2	-2754
SDHB	-2550
DLST	-2432
SUCLG1	-1636
IDH3G	-783
CS	2326
ME2	6081

---

PECAM1 interactions

PECAM1 interactions

	757
set	PECAM1 interactions
setSize	11
pANOVA	0.00138
s.dist	0.557
p.adjustANOVA	0.0134

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	6930
PTPN6	6928
LYN	6800
FYN	6628
INPP5D	6419
ITGB3	6214
SRC	5659
YES1	2437
PLCG1	2357
PTPN11	-1824
ITGAV	-2553

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	6930
PTPN6	6928
LYN	6800
FYN	6628
INPP5D	6419
ITGB3	6214
SRC	5659
YES1	2437
PLCG1	2357
PTPN11	-1824
ITGAV	-2553

---

Regulation of IFNA signaling

Regulation of IFNA signaling

	927
set	Regulation of IFNA signaling
setSize	12
pANOVA	0.000933
s.dist	0.552
p.adjustANOVA	0.00968

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SOCS1	7052.0
STAT1	7016.0
PTPN6	6928.0
USP18	6889.5
STAT2	6788.0
SOCS3	6701.0
IFNAR2	6193.0
TYK2	3887.0
PTPN1	2632.0
IFNAR1	1822.0
PTPN11	-1824.0
JAK1	-4324.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SOCS1	7052.0
STAT1	7016.0
PTPN6	6928.0
USP18	6889.5
STAT2	6788.0
SOCS3	6701.0
IFNAR2	6193.0
TYK2	3887.0
PTPN1	2632.0
IFNAR1	1822.0
PTPN11	-1824.0
JAK1	-4324.0

---

Assembly of collagen fibrils and other multimeric structures

Assembly of collagen fibrils and other multimeric structures

	89
set	Assembly of collagen fibrils and other multimeric structures
setSize	49
pANOVA	7.73e-11
s.dist	0.537
p.adjustANOVA	4.93e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL7A1	6878
CTSS	6806
LOXL3	6749
COL5A3	6726
COL9A1	6699
COL27A1	6620
COL1A1	6328
COL1A2	6101
PLEC	6062
COL18A1	6055
COL3A1	5975
COL5A1	5864
COL5A2	5824
BMP1	5821
LOXL1	5716
COL8A1	5665
COL6A6	5583
COL6A1	5460
COL9A3	5452
COL11A1	5432

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL7A1	6878
CTSS	6806
LOXL3	6749
COL5A3	6726
COL9A1	6699
COL27A1	6620
COL1A1	6328
COL1A2	6101
PLEC	6062
COL18A1	6055
COL3A1	5975
COL5A1	5864
COL5A2	5824
BMP1	5821
LOXL1	5716
COL8A1	5665
COL6A6	5583
COL6A1	5460
COL9A3	5452
COL11A1	5432
LOX	5342
COL6A2	5323
COL6A3	5260
PXDN	5032
COL4A1	4992
LAMA3	4976
COL15A1	4923
ITGB4	4884
LOXL2	4742
COL11A2	4735
PCOLCE	4676
COL8A2	4585
ITGA6	3947
TLL1	3591
LAMC2	3531
LOXL4	3126
COL2A1	3109
COL24A1	3083
COL6A5	2404
COL4A2	2049
COL4A4	1745
DST	1680
COL4A5	1226
CTSB	1051
CTSV	-598
TLL2	-2473
CD151	-2579
LAMB3	-3038
COL4A3	-5119

---

Inflammasomes

Inflammasomes

	509
set	Inflammasomes
setSize	19
pANOVA	6.24e-05
s.dist	0.531
p.adjustANOVA	0.00106

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NLRP3	7005
NLRP1	6996
P2RX7	6921
PSTPIP1	6891
NLRC4	6704
AIM2	6694
BCL2	6640
CASP1	6506
NFKB2	6319
PANX1	5828
PYCARD	5776
TXN	5181
RELA	3436
APP	2289
SUGT1	-55
NFKB1	-373
BCL2L1	-935
HSP90AB1	-1115
TXNIP	-4596

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NLRP3	7005
NLRP1	6996
P2RX7	6921
PSTPIP1	6891
NLRC4	6704
AIM2	6694
BCL2	6640
CASP1	6506
NFKB2	6319
PANX1	5828
PYCARD	5776
TXN	5181
RELA	3436
APP	2289
SUGT1	-55
NFKB1	-373
BCL2L1	-935
HSP90AB1	-1115
TXNIP	-4596

---

Collagen chain trimerization

Collagen chain trimerization

	195
set	Collagen chain trimerization
setSize	40
pANOVA	8.33e-09
s.dist	0.526
p.adjustANOVA	3.46e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL7A1	6878
COL5A3	6726
COL9A1	6699
COL27A1	6620
COL1A1	6328
COL16A1	6167
COL1A2	6101
COL18A1	6055
COL3A1	5975
COL13A1	5885
COL5A1	5864
COL5A2	5824
COL8A1	5665
COL6A6	5583
COL6A1	5460
COL9A3	5452
COL11A1	5432
COL6A2	5323
COL6A3	5260
COL12A1	5109

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL7A1	6878
COL5A3	6726
COL9A1	6699
COL27A1	6620
COL1A1	6328
COL16A1	6167
COL1A2	6101
COL18A1	6055
COL3A1	5975
COL13A1	5885
COL5A1	5864
COL5A2	5824
COL8A1	5665
COL6A6	5583
COL6A1	5460
COL9A3	5452
COL11A1	5432
COL6A2	5323
COL6A3	5260
COL12A1	5109
COL4A1	4992
COL15A1	4923
COL19A1	4842
COL11A2	4735
COL14A1	4637
COL8A2	4585
COL28A1	3826
COL23A1	3682
COL26A1	3579
COL2A1	3109
COL24A1	3083
COL6A5	2404
COL4A2	2049
COL4A4	1745
COL4A6	1656
COL4A5	1226
COL22A1	512
COL20A1	-4777
COL4A3	-5119
COL25A1	-5138

---

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

	1173
set	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize	13
pANOVA	0.00112
s.dist	0.522
p.adjustANOVA	0.0113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	6804
E2F7	6779
E2F1	6711
E2F8	6520
ZNF385A	6056
CDK2	5635
ARID3A	5449
CCNE1	5283
TP53	4524
CCNA2	3478
CCNE2	-656
PCBP4	-2156
CDKN1B	-3072

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	6804
E2F7	6779
E2F1	6711
E2F8	6520
ZNF385A	6056
CDK2	5635
ARID3A	5449
CCNE1	5283
TP53	4524
CCNA2	3478
CCNE2	-656
PCBP4	-2156
CDKN1B	-3072

---

Interferon gamma signaling

Interferon gamma signaling

	534
set	Interferon gamma signaling
setSize	61
pANOVA	7.18e-12
s.dist	0.507
p.adjustANOVA	6.81e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIM5	7068.0
GBP4	7066.5
GBP7	7066.5
OAS1	7054.0
SOCS1	7052.0
GBP5	7051.0
IRF1	7048.0
OAS2	7035.0
STAT1	7016.0
FCGR1A	7006.5
FCGR1B	7006.5
OAS3	6999.0
GBP6	6986.0
IRF7	6974.0
ICAM1	6966.0
PTPN6	6928.0
OASL	6867.0
IRF5	6827.0
TRIM21	6793.0
PTAFR	6782.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIM5	7068.0
GBP4	7066.5
GBP7	7066.5
OAS1	7054.0
SOCS1	7052.0
GBP5	7051.0
IRF1	7048.0
OAS2	7035.0
STAT1	7016.0
FCGR1A	7006.5
FCGR1B	7006.5
OAS3	6999.0
GBP6	6986.0
IRF7	6974.0
ICAM1	6966.0
PTPN6	6928.0
OASL	6867.0
IRF5	6827.0
TRIM21	6793.0
PTAFR	6782.0
B2M	6748.0
VCAM1	6715.0
SOCS3	6701.0
CD44	6623.0
CIITA	6574.0
PRKCD	6548.0
TRIM25	6459.0
TRIM14	6435.0
IFNGR2	6105.0
TRIM62	5981.0
IFI30	5942.0
HLA-DQB1	5799.5
HLA-DQB2	5799.5
NCAM1	5663.0
IRF9	5547.0
IRF4	5379.0
TRIM8	5176.0
TRIM2	4740.0
PML	4348.0
IRF2	3149.0
PTPN1	2632.0
TRIM3	1888.0
IRF3	1422.0
CAMK2G	1377.0
SUMO1	543.0
IFNGR1	364.0
TRIM26	143.0
TRIM38	-26.0
CAMK2A	-380.0
TRIM35	-387.0
PIAS1	-700.0
JAK2	-796.0
PTPN2	-1490.0
MID1	-1727.0
PTPN11	-1824.0
CAMK2B	-2088.0
CAMK2D	-2687.0
TRIM68	-3675.0
JAK1	-4324.0
TRIM17	-4552.0
TRIM45	-5217.0

---

Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation

	456
set	Glyoxylate metabolism and glycine degradation
setSize	23
pANOVA	5.37e-05
s.dist	-0.487
p.adjustANOVA	0.000939

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HOGA1	-5694
LIPT1	-5644
PDHA1	-5413
PDHB	-5309
NDUFAB1	-5203
GOT2	-4621
DLAT	-4509
DLD	-4155
LIPT2	-4107
OGDH	-3792
PXMP2	-3425
GNMT	-3278
BCKDHB	-3228
PDHX	-3090
DLST	-2432
GCSH	-1927
GRHPR	-895
DDO	-748
DBT	53
DHTKD1	438

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HOGA1	-5694.0
LIPT1	-5644.0
PDHA1	-5413.0
PDHB	-5309.0
NDUFAB1	-5203.0
GOT2	-4621.0
DLAT	-4509.0
DLD	-4155.0
LIPT2	-4107.0
OGDH	-3792.0
PXMP2	-3425.0
GNMT	-3278.0
BCKDHB	-3228.0
PDHX	-3090.0
DLST	-2432.0
GCSH	-1927.0
GRHPR	-895.0
DDO	-748.0
DBT	53.0
DHTKD1	438.0
LIAS	470.0
AMT	2407.0
BCKDHA	3773.5

---

Antimicrobial peptides

Antimicrobial peptides

	77
set	Antimicrobial peptides
setSize	11
pANOVA	0.00575
s.dist	0.481
p.adjustANOVA	0.041

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC11A1	7049
CCR2	7045
TLR1	6810
LYZ	6478
CD4	6448
TLR2	6429
ATOX1	4733
ART1	1654
PDZD11	861
ATP7A	-1259
CLU	-5719

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC11A1	7049
CCR2	7045
TLR1	6810
LYZ	6478
CD4	6448
TLR2	6429
ATOX1	4733
ART1	1654
PDZD11	861
ATP7A	-1259
CLU	-5719

---

NCAM1 interactions

NCAM1 interactions

	675
set	NCAM1 interactions
setSize	30
pANOVA	7.15e-06
s.dist	0.474
p.adjustANOVA	0.000173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CACNA1D	6967
CACNA1I	6754
COL9A1	6699
CACNA1H	6266
ST8SIA4	6147
GFRA2	6103
ST8SIA2	6029
CACNA1G	5852
NCAM1	5663
COL6A6	5583
CACNB3	5489
COL6A1	5460
COL9A3	5452
CACNB1	5397
COL6A2	5323
COL6A3	5260
CACNB4	5115
COL4A1	4992
CACNA1C	4070
AGRN	3844

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CACNA1D	6967
CACNA1I	6754
COL9A1	6699
CACNA1H	6266
ST8SIA4	6147
GFRA2	6103
ST8SIA2	6029
CACNA1G	5852
NCAM1	5663
COL6A6	5583
CACNB3	5489
COL6A1	5460
COL9A3	5452
CACNB1	5397
COL6A2	5323
COL6A3	5260
CACNB4	5115
COL4A1	4992
CACNA1C	4070
AGRN	3844
GFRA1	3349
CACNB2	3144
COL6A5	2404
COL4A2	2049
COL4A4	1745
COL4A5	1226
CACNA1S	-1774
NRTN	-4567
COL4A3	-5119
GDNF	-5956

---

DAP12 interactions

DAP12 interactions

	230
set	DAP12 interactions
setSize	28
pANOVA	1.46e-05
s.dist	0.473
p.adjustANOVA	0.000307

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIRPB1	7073.5
LCK	6930.0
B2M	6748.0
BTK	6737.0
LCP2	6729.0
PLCG2	6686.0
FYN	6628.0
CD300LB	6598.0
TREM2	6589.0
TYROBP	6545.0
KLRK1	6516.0
SYK	6507.0
GRAP2	6341.0
VAV3	6297.0
LAT	5744.0
SHC1	5628.0
GRB2	4408.0
VAV2	4166.0
NRAS	2908.0
PLCG1	2357.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIRPB1	7073.5
LCK	6930.0
B2M	6748.0
BTK	6737.0
LCP2	6729.0
PLCG2	6686.0
FYN	6628.0
CD300LB	6598.0
TREM2	6589.0
TYROBP	6545.0
KLRK1	6516.0
SYK	6507.0
GRAP2	6341.0
VAV3	6297.0
LAT	5744.0
SHC1	5628.0
GRB2	4408.0
VAV2	4166.0
NRAS	2908.0
PLCG1	2357.0
HRAS	1974.0
PIK3CB	687.0
PIK3R1	424.0
PIK3R2	-2547.0
PIK3CA	-3434.0
KRAS	-4015.0
RAC1	-4366.0
SOS1	-5189.0

---

The NLRP3 inflammasome

The NLRP3 inflammasome

	1192
set	The NLRP3 inflammasome
setSize	14
pANOVA	0.00266
s.dist	0.464
p.adjustANOVA	0.0219

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NLRP3	7005
P2RX7	6921
PSTPIP1	6891
CASP1	6506
NFKB2	6319
PANX1	5828
PYCARD	5776
TXN	5181
RELA	3436
APP	2289
SUGT1	-55
NFKB1	-373
HSP90AB1	-1115
TXNIP	-4596

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NLRP3	7005
P2RX7	6921
PSTPIP1	6891
CASP1	6506
NFKB2	6319
PANX1	5828
PYCARD	5776
TXN	5181
RELA	3436
APP	2289
SUGT1	-55
NFKB1	-373
HSP90AB1	-1115
TXNIP	-4596

---

Interleukin-20 family signaling

Interleukin-20 family signaling

	545
set	Interleukin-20 family signaling
setSize	14
pANOVA	0.00278
s.dist	0.462
p.adjustANOVA	0.0227

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT1	7016.0
STAT2	6788.0
SOCS3	6701.0
IL10RB	6238.5
STAT4	6113.0
JAK3	5830.0
IL20RB	5090.0
TYK2	3887.0
STAT3	3834.0
STAT5A	3158.0
STAT5B	2107.0
JAK2	-796.0
PTPN11	-1824.0
JAK1	-4324.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT1	7016.0
STAT2	6788.0
SOCS3	6701.0
IL10RB	6238.5
STAT4	6113.0
JAK3	5830.0
IL20RB	5090.0
TYK2	3887.0
STAT3	3834.0
STAT5A	3158.0
STAT5B	2107.0
JAK2	-796.0
PTPN11	-1824.0
JAK1	-4324.0

---

Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis

	177
set	Chondroitin sulfate biosynthesis
setSize	16
pANOVA	0.00149
s.dist	0.459
p.adjustANOVA	0.0138

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CHST12	6041
CSGALNACT1	6010
CHST11	5977
BGN	5853
CHSY3	5630
CHPF2	5138
VCAN	4921
CHSY1	4702
CHST7	4439
CHPF	3712
CHST3	3341
CSPG4	2709
CHST9	2014
DCN	89
CSGALNACT2	-688
CSPG5	-3270

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CHST12	6041
CSGALNACT1	6010
CHST11	5977
BGN	5853
CHSY3	5630
CHPF2	5138
VCAN	4921
CHSY1	4702
CHST7	4439
CHPF	3712
CHST3	3341
CSPG4	2709
CHST9	2014
DCN	89
CSGALNACT2	-688
CSPG5	-3270

---

Regulation of KIT signaling

Regulation of KIT signaling

	930
set	Regulation of KIT signaling
setSize	16
pANOVA	0.0015
s.dist	0.458
p.adjustANOVA	0.0138

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SOCS1	7052
LCK	6930
PTPN6	6928
LYN	6800
FYN	6628
SH2B2	6054
SRC	5659
KIT	4530
KITLG	4421
GRB2	4408
SH2B3	3544
YES1	2437
SOCS6	-313
CBL	-1040
PRKCA	-2267
SOS1	-5189

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SOCS1	7052
LCK	6930
PTPN6	6928
LYN	6800
FYN	6628
SH2B2	6054
SRC	5659
KIT	4530
KITLG	4421
GRB2	4408
SH2B3	3544
YES1	2437
SOCS6	-313
CBL	-1040
PRKCA	-2267
SOS1	-5189

---

RIPK1-mediated regulated necrosis

RIPK1-mediated regulated necrosis

	869
set	RIPK1-mediated regulated necrosis
setSize	14
pANOVA	0.00302
s.dist	0.458
p.adjustANOVA	0.0236

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CASP8	6951.0
MLKL	6898.0
RIPK3	6060.0
TNFSF10	6051.0
TRADD	5878.0
BIRC3	5788.0
TRAF2	5154.0
FADD	5049.0
CFLAR	4458.0
FAS	2909.0
RIPK1	103.0
BIRC2	-1331.0
TNFRSF10A	-2256.5
TNFRSF10B	-2256.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CASP8	6951.0
MLKL	6898.0
RIPK3	6060.0
TNFSF10	6051.0
TRADD	5878.0
BIRC3	5788.0
TRAF2	5154.0
FADD	5049.0
CFLAR	4458.0
FAS	2909.0
RIPK1	103.0
BIRC2	-1331.0
TNFRSF10A	-2256.5
TNFRSF10B	-2256.5

---

Regulated Necrosis

Regulated Necrosis

	917
set	Regulated Necrosis
setSize	14
pANOVA	0.00302
s.dist	0.458
p.adjustANOVA	0.0236

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CASP8	6951.0
MLKL	6898.0
RIPK3	6060.0
TNFSF10	6051.0
TRADD	5878.0
BIRC3	5788.0
TRAF2	5154.0
FADD	5049.0
CFLAR	4458.0
FAS	2909.0
RIPK1	103.0
BIRC2	-1331.0
TNFRSF10A	-2256.5
TNFRSF10B	-2256.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CASP8	6951.0
MLKL	6898.0
RIPK3	6060.0
TNFSF10	6051.0
TRADD	5878.0
BIRC3	5788.0
TRAF2	5154.0
FADD	5049.0
CFLAR	4458.0
FAS	2909.0
RIPK1	103.0
BIRC2	-1331.0
TNFRSF10A	-2256.5
TNFRSF10B	-2256.5

---

Cell recruitment (pro-inflammatory response)

Cell recruitment (pro-inflammatory response)

	160
set	Cell recruitment (pro-inflammatory response)
setSize	19
pANOVA	0.000561
s.dist	0.457
p.adjustANOVA	0.00632

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NLRP3	7005
P2RX7	6921
PSTPIP1	6891
C3AR1	6750
CASP1	6506
ENTPD1	6498
NFKB2	6319
PYCARD	5776
IL18	5516
C3	5368
P2RX4	5353
TXN	5181
RELA	3436
SUGT1	-55
NFKB1	-373
HSP90AB1	-1115
NT5E	-1719
ENTPD5	-2631
TXNIP	-4596

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NLRP3	7005
P2RX7	6921
PSTPIP1	6891
C3AR1	6750
CASP1	6506
ENTPD1	6498
NFKB2	6319
PYCARD	5776
IL18	5516
C3	5368
P2RX4	5353
TXN	5181
RELA	3436
SUGT1	-55
NFKB1	-373
HSP90AB1	-1115
NT5E	-1719
ENTPD5	-2631
TXNIP	-4596

---

Purinergic signaling in leishmaniasis infection

Purinergic signaling in leishmaniasis infection

	847
set	Purinergic signaling in leishmaniasis infection
setSize	19
pANOVA	0.000561
s.dist	0.457
p.adjustANOVA	0.00632

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NLRP3	7005
P2RX7	6921
PSTPIP1	6891
C3AR1	6750
CASP1	6506
ENTPD1	6498
NFKB2	6319
PYCARD	5776
IL18	5516
C3	5368
P2RX4	5353
TXN	5181
RELA	3436
SUGT1	-55
NFKB1	-373
HSP90AB1	-1115
NT5E	-1719
ENTPD5	-2631
TXNIP	-4596

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NLRP3	7005
P2RX7	6921
PSTPIP1	6891
C3AR1	6750
CASP1	6506
ENTPD1	6498
NFKB2	6319
PYCARD	5776
IL18	5516
C3	5368
P2RX4	5353
TXN	5181
RELA	3436
SUGT1	-55
NFKB1	-373
HSP90AB1	-1115
NT5E	-1719
ENTPD5	-2631
TXNIP	-4596

---

N-Glycan antennae elongation

N-Glycan antennae elongation

	671
set	N-Glycan antennae elongation
setSize	14
pANOVA	0.00324
s.dist	0.454
p.adjustANOVA	0.025

Top enriched genes

Top 20 genes

GeneID	Gene Rank
B4GALT6	6848
ST8SIA2	6029
ST3GAL4	5518
ST6GAL1	5493
ST8SIA6	5488
MGAT4A	4632
B4GALT2	4201
MGAT5	3755
B4GALT5	3190
B4GALT4	2737
MGAT4C	2124
MGAT4B	1224
B4GALT1	-254
B4GALT3	-1832

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
B4GALT6	6848
ST8SIA2	6029
ST3GAL4	5518
ST6GAL1	5493
ST8SIA6	5488
MGAT4A	4632
B4GALT2	4201
MGAT5	3755
B4GALT5	3190
B4GALT4	2737
MGAT4C	2124
MGAT4B	1224
B4GALT1	-254
B4GALT3	-1832

---

ATF6 (ATF6-alpha) activates chaperone genes

ATF6 (ATF6-alpha) activates chaperone genes

	20
set	ATF6 (ATF6-alpha) activates chaperone genes
setSize	10
pANOVA	0.0132
s.dist	-0.452
p.adjustANOVA	0.0757

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSP90B1	-5499
HSPA5	-5426
NFYC	-3931
XBP1	-3677
ATF6	-3365
NFYA	-2728
NFYB	-1704
DDIT3	-967
CALR	1232
ATF4	2028

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSP90B1	-5499
HSPA5	-5426
NFYC	-3931
XBP1	-3677
ATF6	-3365
NFYA	-2728
NFYB	-1704
DDIT3	-967
CALR	1232
ATF4	2028

---

Attenuation phase

Attenuation phase

	93
set	Attenuation phase
setSize	21
pANOVA	0.000369
s.dist	-0.449
p.adjustANOVA	0.00495

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSPH1	-5835.0
HSPA8	-5497.0
DNAJB1	-5275.0
FKBP4	-5233.0
HSPA1A	-4787.5
HSPA1B	-4787.5
MRPL18	-4773.0
HSPA1L	-4680.0
EP300	-4459.0
HSPA2	-3226.0
SERPINH1	-2112.0
CREBBP	-1573.0
HSP90AA1	-1140.0
HSP90AB1	-1115.0
TNFRSF21	-879.0
PTGES3	-733.0
HSF1	-671.0
HSBP1	994.0
DEDD2	1287.0
COL4A6	1656.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSPH1	-5835.0
HSPA8	-5497.0
DNAJB1	-5275.0
FKBP4	-5233.0
HSPA1A	-4787.5
HSPA1B	-4787.5
MRPL18	-4773.0
HSPA1L	-4680.0
EP300	-4459.0
HSPA2	-3226.0
SERPINH1	-2112.0
CREBBP	-1573.0
HSP90AA1	-1140.0
HSP90AB1	-1115.0
TNFRSF21	-879.0
PTGES3	-733.0
HSF1	-671.0
HSBP1	994.0
DEDD2	1287.0
COL4A6	1656.0
DNAJB6	2886.0

---

Nucleotide-like (purinergic) receptors

Nucleotide-like (purinergic) receptors

	739
set	Nucleotide-like (purinergic) receptors
setSize	11
pANOVA	0.0104
s.dist	0.446
p.adjustANOVA	0.064

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADORA2B	6500
ADORA2A	6345
P2RY10	6235
P2RY14	6139
P2RY6	6018
P2RY12	5932
P2RY2	3647
LPAR4	3534
ADORA1	-1725
LPAR6	-2153
P2RY1	-2417

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADORA2B	6500
ADORA2A	6345
P2RY10	6235
P2RY14	6139
P2RY6	6018
P2RY12	5932
P2RY2	3647
LPAR4	3534
ADORA1	-1725
LPAR6	-2153
P2RY1	-2417

---

Chemokine receptors bind chemokines

Chemokine receptors bind chemokines

	174
set	Chemokine receptors bind chemokines
setSize	22
pANOVA	0.000294
s.dist	0.446
p.adjustANOVA	0.00403

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCR2	7045
CXCL10	7043
CCL2	6937
CCL7	6865
CXCL16	6829
CXCL9	6770
CCL5	6422
CXCR4	6087
ACKR3	5621
CXCL12	5613
CCL22	5558
CX3CL1	5430
CCR7	5184
CXCR6	5107
CCL11	2685
ACKR2	2194
CCR9	-400
ACKR4	-1095
CX3CR1	-1234
CCL25	-2735

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCR2	7045
CXCL10	7043
CCL2	6937
CCL7	6865
CXCL16	6829
CXCL9	6770
CCL5	6422
CXCR4	6087
ACKR3	5621
CXCL12	5613
CCL22	5558
CX3CL1	5430
CCR7	5184
CXCR6	5107
CCL11	2685
ACKR2	2194
CCR9	-400
ACKR4	-1095
CX3CR1	-1234
CCL25	-2735
CCL27	-4941
CCL28	-5001

---

Unwinding of DNA

Unwinding of DNA

	1267
set	Unwinding of DNA
setSize	12
pANOVA	0.00793
s.dist	0.443
p.adjustANOVA	0.0519

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM5	6756
MCM3	6287
MCM2	5905
GINS2	5087
GINS1	4801
MCM7	4490
GINS3	4162
CDC45	3643
MCM4	1060
MCM8	55
MCM6	-36
GINS4	-994

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM5	6756
MCM3	6287
MCM2	5905
GINS2	5087
GINS1	4801
MCM7	4490
GINS3	4162
CDC45	3643
MCM4	1060
MCM8	55
MCM6	-36
GINS4	-994

---

GPVI-mediated activation cascade

GPVI-mediated activation cascade

	421
set	GPVI-mediated activation cascade
setSize	30
pANOVA	3.23e-05
s.dist	0.439
p.adjustANOVA	0.000603

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAC2	7001
VAV1	6936
PIK3R5	6934
LCK	6930
PTPN6	6928
LYN	6800
LCP2	6729
PLCG2	6686
PIK3CG	6658
FYN	6628
PIK3R6	6587
SYK	6507
VAV3	6297
RHOG	6050
LAT	5744
PDPN	4962
VAV2	4166
FCER1G	2052
PIK3R3	1313
RHOA	1201

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAC2	7001
VAV1	6936
PIK3R5	6934
LCK	6930
PTPN6	6928
LYN	6800
LCP2	6729
PLCG2	6686
PIK3CG	6658
FYN	6628
PIK3R6	6587
SYK	6507
VAV3	6297
RHOG	6050
LAT	5744
PDPN	4962
VAV2	4166
FCER1G	2052
PIK3R3	1313
RHOA	1201
PIK3CB	687
PDPK1	475
PIK3R1	424
PRKCZ	383
RHOB	184
CDC42	-972
PTPN11	-1824
PIK3R2	-2547
PIK3CA	-3434
RAC1	-4366

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	202
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	0.0121
s.dist	0.437
p.adjustANOVA	0.0709

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDK1	6907.0
NCAPG	6572.0
CCNB1	6244.0
NCAPH	5622.0
SMC4	5296.0
SMC2	3563.0
CSNK2A1	1289.0
NCAPD2	1157.0
CSNK2A2	433.0
CCNB2	204.0
CSNK2B	96.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDK1	6907.0
NCAPG	6572.0
CCNB1	6244.0
NCAPH	5622.0
SMC4	5296.0
SMC2	3563.0
CSNK2A1	1289.0
NCAPD2	1157.0
CSNK2A2	433.0
CCNB2	204.0
CSNK2B	96.5

---

DAP12 signaling

DAP12 signaling

	231
set	DAP12 signaling
setSize	26
pANOVA	0.000122
s.dist	0.435
p.adjustANOVA	0.00195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	6930
B2M	6748
BTK	6737
LCP2	6729
PLCG2	6686
FYN	6628
TREM2	6589
TYROBP	6545
KLRK1	6516
SYK	6507
GRAP2	6341
VAV3	6297
LAT	5744
SHC1	5628
GRB2	4408
VAV2	4166
NRAS	2908
PLCG1	2357
HRAS	1974
PIK3CB	687

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	6930
B2M	6748
BTK	6737
LCP2	6729
PLCG2	6686
FYN	6628
TREM2	6589
TYROBP	6545
KLRK1	6516
SYK	6507
GRAP2	6341
VAV3	6297
LAT	5744
SHC1	5628
GRB2	4408
VAV2	4166
NRAS	2908
PLCG1	2357
HRAS	1974
PIK3CB	687
PIK3R1	424
PIK3R2	-2547
PIK3CA	-3434
KRAS	-4015
RAC1	-4366
SOS1	-5189

---

Methylation

Methylation

	637
set	Methylation
setSize	11
pANOVA	0.013
s.dist	-0.433
p.adjustANOVA	0.0748

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAT2A	-5053
TPMT	-4557
MTRR	-4436
COMT	-4223
AHCY	-3360
AS3MT	-2684
MTR	-2300
MAT2B	-1683
GSTO1	-1444
N6AMT1	-955
NNMT	5670

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAT2A	-5053
TPMT	-4557
MTRR	-4436
COMT	-4223
AHCY	-3360
AS3MT	-2684
MTR	-2300
MAT2B	-1683
GSTO1	-1444
N6AMT1	-955
NNMT	5670

---

Defects in vitamin and cofactor metabolism

Defects in vitamin and cofactor metabolism

	261
set	Defects in vitamin and cofactor metabolism
setSize	19
pANOVA	0.00132
s.dist	-0.426
p.adjustANOVA	0.013

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MMAA	-5724
MMACHC	-5331
LMBRD1	-5299
MTRR	-4436
PCCA	-3869
MCCC1	-3801
MMADHC	-3581
HLCS	-3410
MTR	-2300
MMAB	-2032
PC	-2027
ACACA	-1930
MCCC2	-1891
PCCB	-1856
TCN2	-1686
ABCD4	-83
BTD	358
CD320	2483
CUBN	4109

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MMAA	-5724
MMACHC	-5331
LMBRD1	-5299
MTRR	-4436
PCCA	-3869
MCCC1	-3801
MMADHC	-3581
HLCS	-3410
MTR	-2300
MMAB	-2032
PC	-2027
ACACA	-1930
MCCC2	-1891
PCCB	-1856
TCN2	-1686
ABCD4	-83
BTD	358
CD320	2483
CUBN	4109

---

Initial triggering of complement

Initial triggering of complement

	516
set	Initial triggering of complement
setSize	14
pANOVA	0.00596
s.dist	0.424
p.adjustANOVA	0.0421

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C1QC	6794.0
C4A	6445.5
C4B	6445.5
C1QA	6381.0
C1QB	6302.0
C1S	5680.0
C3	5368.0
C1R	3867.0
CFD	1905.0
CRP	1753.0
C2	1585.0
MASP2	-2.0
GZMM	-413.0
MASP1	-5692.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C1QC	6794.0
C4A	6445.5
C4B	6445.5
C1QA	6381.0
C1QB	6302.0
C1S	5680.0
C3	5368.0
C1R	3867.0
CFD	1905.0
CRP	1753.0
C2	1585.0
MASP2	-2.0
GZMM	-413.0
MASP1	-5692.0

---

Transcriptional regulation of granulopoiesis

Transcriptional regulation of granulopoiesis

	1230
set	Transcriptional regulation of granulopoiesis
setSize	27
pANOVA	0.000166
s.dist	0.419
p.adjustANOVA	0.00251

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSF3R	7046.0
SPI1	6952.0
CDKN1A	6804.0
FLI1	6802.0
E2F1	6711.0
RARA	6652.0
RUNX1	6408.0
MYB	6374.0
MYC	5757.0
CDK2	5635.0
RXRA	5440.0
CEBPA	5133.0
LEF1	4688.0
PML	4348.0
KLF5	4203.0
STAT3	3834.0
DEK	3127.0
CBFB	2469.0
IL6R	2461.0
TFDP1	2411.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSF3R	7046.0
SPI1	6952.0
CDKN1A	6804.0
FLI1	6802.0
E2F1	6711.0
RARA	6652.0
RUNX1	6408.0
MYB	6374.0
MYC	5757.0
CDK2	5635.0
RXRA	5440.0
CEBPA	5133.0
LEF1	4688.0
PML	4348.0
KLF5	4203.0
STAT3	3834.0
DEK	3127.0
CBFB	2469.0
IL6R	2461.0
TFDP1	2411.5
KMT2A	1807.0
CDK4	843.0
H2AFX	713.0
CEBPB	-3889.0
CREB1	-4203.0
EP300	-4459.0
TFDP2	-5627.0

---

Defects in cobalamin (B12) metabolism

Defects in cobalamin (B12) metabolism

	260
set	Defects in cobalamin (B12) metabolism
setSize	11
pANOVA	0.0167
s.dist	-0.417
p.adjustANOVA	0.0882

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MMAA	-5724
MMACHC	-5331
LMBRD1	-5299
MTRR	-4436
MMADHC	-3581
MTR	-2300
MMAB	-2032
TCN2	-1686
ABCD4	-83
CD320	2483
CUBN	4109

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MMAA	-5724
MMACHC	-5331
LMBRD1	-5299
MTRR	-4436
MMADHC	-3581
MTR	-2300
MMAB	-2032
TCN2	-1686
ABCD4	-83
CD320	2483
CUBN	4109

---

TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling

	1163
set	TNFR1-induced proapoptotic signaling
setSize	13
pANOVA	0.00933
s.dist	0.416
p.adjustANOVA	0.0587

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CASP8	6951
TNF	6561
TNFRSF1A	6327
TRADD	5878
TNFAIP3	5465
TRAF2	5154
FADD	5049
USP21	2203
OTUD7B	2024
CYLD	2020
RIPK1	103
USP4	-7
USP2	-5303

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CASP8	6951
TNF	6561
TNFRSF1A	6327
TRADD	5878
TNFAIP3	5465
TRAF2	5154
FADD	5049
USP21	2203
OTUD7B	2024
CYLD	2020
RIPK1	103
USP4	-7
USP2	-5303

---

Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases

	43
set	Activation of Matrix Metalloproteinases
setSize	13
pANOVA	0.0097
s.dist	0.414
p.adjustANOVA	0.0605

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MMP25	6824
TIMP1	6411
MMP14	6309
COL18A1	6055
FURIN	5015
MMP16	4900
SPOCK3	4516
MMP2	4135
MMP15	1019
MMP11	82
TIMP2	-491
CTSV	-598
CTSK	-1931

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MMP25	6824
TIMP1	6411
MMP14	6309
COL18A1	6055
FURIN	5015
MMP16	4900
SPOCK3	4516
MMP2	4135
MMP15	1019
MMP11	82
TIMP2	-491
CTSV	-598
CTSK	-1931

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] MASS_7.3-51.6               fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [49] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [52] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [55] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [58] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [61] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [64] evaluate_0.14          lattice_0.20-41        htmlwidgets_1.5.1     
## [67] bit_1.1-15.2           tidyselect_1.1.0       plyr_1.8.6            
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          locfit_1.5-9.4         grid_4.0.2            
## [85] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [88] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [91] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report