Mitch Report

date generated: 2020-07-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## A4GALT  1.21526264
## AAAS   -0.15967183
## AACS   -0.26770637
## AAED1  -0.26129262
## AAGAB  -0.14127424
## AAK1   -0.08861407

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2400
num_genes_in_profile	11694
duplicated_genes_present	0
num_profile_genes_in_sets	6733
num_profile_genes_not_in_sets	4961

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1126
num_genesets_included	1274

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Initial triggering of complement	12	1.09e-05	0.733	9.24e-04
Signal regulatory protein family interactions	13	1.70e-05	0.689	1.36e-03
Xenobiotics	14	1.94e-05	-0.659	1.45e-03
Chemokine receptors bind chemokines	16	2.48e-04	0.529	9.91e-03
RIP-mediated NFkB activation via ZBP1	17	1.63e-04	0.528	7.15e-03
Plasma lipoprotein assembly	15	7.08e-04	-0.505	2.03e-02
Interleukin-4 and Interleukin-13 signaling	73	1.79e-13	0.499	1.14e-10
Cristae formation	10	7.29e-03	-0.490	9.68e-02
Cell recruitment (pro-inflammatory response)	17	5.08e-04	0.487	1.62e-02
Purinergic signaling in leishmaniasis infection	17	5.08e-04	0.487	1.62e-02
Activation of Matrix Metalloproteinases	15	2.19e-03	0.457	4.32e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.37e-02	-0.450	1.42e-01
The NLRP3 inflammasome	13	6.06e-03	0.440	8.30e-02
Interleukin-10 signaling	19	9.14e-04	0.439	2.48e-02
Diseases associated with the TLR signaling cascade	19	1.14e-03	0.431	2.68e-02
Diseases of Immune System	19	1.14e-03	0.431	2.68e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	10	1.85e-02	0.430	1.60e-01
ZBP1(DAI) mediated induction of type I IFNs	20	1.00e-03	0.425	2.58e-02
Defective B4GALT7 causes EDS, progeroid type	15	4.80e-03	0.421	7.11e-02
Interleukin-37 signaling	17	2.92e-03	0.417	5.09e-02
PCNA-Dependent Long Patch Base Excision Repair	19	2.02e-03	-0.409	4.22e-02
Translesion synthesis by REV1	14	8.16e-03	-0.408	1.04e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	17	4.85e-03	0.395	7.11e-02
Synthesis of IP2, IP, and Ins in the cytosol	12	1.84e-02	0.393	1.60e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	1.48e-02	-0.391	1.45e-01
FCGR activation	10	3.25e-02	0.390	2.31e-01
Post-chaperonin tubulin folding pathway	15	9.29e-03	0.388	1.13e-01
Adenylate cyclase inhibitory pathway	12	2.19e-02	0.382	1.80e-01
Translesion synthesis by POLI	15	1.07e-02	-0.381	1.24e-01
Mitochondrial tRNA aminoacylation	18	5.28e-03	-0.380	7.56e-02
Defective B3GAT3 causes JDSSDHD	15	1.09e-02	0.380	1.25e-01
Cell-extracellular matrix interactions	15	1.10e-02	0.379	1.25e-01
Regulation of Complement cascade	24	1.30e-03	0.379	2.90e-02
Removal of the Flap Intermediate from the C-strand	16	8.66e-03	-0.379	1.08e-01
Striated Muscle Contraction	31	2.67e-04	-0.378	1.00e-02
Complement cascade	27	7.18e-04	0.376	2.03e-02
Interleukin-15 signaling	13	2.07e-02	0.371	1.73e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	15	1.37e-02	0.368	1.42e-01
Mitochondrial calcium ion transport	21	3.74e-03	-0.366	5.89e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	22	3.30e-03	-0.362	5.46e-02
Processing of SMDT1	15	1.58e-02	-0.360	1.49e-01
Mitochondrial protein import	56	3.49e-06	-0.359	4.05e-04
tRNA processing in the mitochondrion	11	4.04e-02	0.357	2.59e-01
Biosynthesis of DHA-derived SPMs	12	3.37e-02	-0.354	2.35e-01
AKT phosphorylates targets in the cytosol	14	2.26e-02	0.352	1.83e-01
Methylation	12	3.54e-02	-0.351	2.41e-01
Interferon alpha/beta signaling	40	1.37e-04	0.349	7.00e-03
Citric acid cycle (TCA cycle)	22	4.86e-03	-0.347	7.11e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	33	6.25e-04	0.344	1.89e-02
Peroxisomal lipid metabolism	24	3.67e-03	-0.343	5.84e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Initial triggering of complement	12	1.09e-05	7.33e-01	9.24e-04
Signal regulatory protein family interactions	13	1.70e-05	6.89e-01	1.36e-03
Xenobiotics	14	1.94e-05	-6.59e-01	1.45e-03
Chemokine receptors bind chemokines	16	2.48e-04	5.29e-01	9.91e-03
RIP-mediated NFkB activation via ZBP1	17	1.63e-04	5.28e-01	7.15e-03
Plasma lipoprotein assembly	15	7.08e-04	-5.05e-01	2.03e-02
Interleukin-4 and Interleukin-13 signaling	73	1.79e-13	4.99e-01	1.14e-10
Cristae formation	10	7.29e-03	-4.90e-01	9.68e-02
Cell recruitment (pro-inflammatory response)	17	5.08e-04	4.87e-01	1.62e-02
Purinergic signaling in leishmaniasis infection	17	5.08e-04	4.87e-01	1.62e-02
Activation of Matrix Metalloproteinases	15	2.19e-03	4.57e-01	4.32e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.37e-02	-4.50e-01	1.42e-01
The NLRP3 inflammasome	13	6.06e-03	4.40e-01	8.30e-02
Interleukin-10 signaling	19	9.14e-04	4.39e-01	2.48e-02
Diseases associated with the TLR signaling cascade	19	1.14e-03	4.31e-01	2.68e-02
Diseases of Immune System	19	1.14e-03	4.31e-01	2.68e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	10	1.85e-02	4.30e-01	1.60e-01
ZBP1(DAI) mediated induction of type I IFNs	20	1.00e-03	4.25e-01	2.58e-02
Defective B4GALT7 causes EDS, progeroid type	15	4.80e-03	4.21e-01	7.11e-02
Interleukin-37 signaling	17	2.92e-03	4.17e-01	5.09e-02
PCNA-Dependent Long Patch Base Excision Repair	19	2.02e-03	-4.09e-01	4.22e-02
Translesion synthesis by REV1	14	8.16e-03	-4.08e-01	1.04e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	17	4.85e-03	3.95e-01	7.11e-02
Synthesis of IP2, IP, and Ins in the cytosol	12	1.84e-02	3.93e-01	1.60e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	1.48e-02	-3.91e-01	1.45e-01
FCGR activation	10	3.25e-02	3.90e-01	2.31e-01
Post-chaperonin tubulin folding pathway	15	9.29e-03	3.88e-01	1.13e-01
Adenylate cyclase inhibitory pathway	12	2.19e-02	3.82e-01	1.80e-01
Translesion synthesis by POLI	15	1.07e-02	-3.81e-01	1.24e-01
Mitochondrial tRNA aminoacylation	18	5.28e-03	-3.80e-01	7.56e-02
Defective B3GAT3 causes JDSSDHD	15	1.09e-02	3.80e-01	1.25e-01
Cell-extracellular matrix interactions	15	1.10e-02	3.79e-01	1.25e-01
Regulation of Complement cascade	24	1.30e-03	3.79e-01	2.90e-02
Removal of the Flap Intermediate from the C-strand	16	8.66e-03	-3.79e-01	1.08e-01
Striated Muscle Contraction	31	2.67e-04	-3.78e-01	1.00e-02
Complement cascade	27	7.18e-04	3.76e-01	2.03e-02
Interleukin-15 signaling	13	2.07e-02	3.71e-01	1.73e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	15	1.37e-02	3.68e-01	1.42e-01
Mitochondrial calcium ion transport	21	3.74e-03	-3.66e-01	5.89e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	22	3.30e-03	-3.62e-01	5.46e-02
Processing of SMDT1	15	1.58e-02	-3.60e-01	1.49e-01
Mitochondrial protein import	56	3.49e-06	-3.59e-01	4.05e-04
tRNA processing in the mitochondrion	11	4.04e-02	3.57e-01	2.59e-01
Biosynthesis of DHA-derived SPMs	12	3.37e-02	-3.54e-01	2.35e-01
AKT phosphorylates targets in the cytosol	14	2.26e-02	3.52e-01	1.83e-01
Methylation	12	3.54e-02	-3.51e-01	2.41e-01
Interferon alpha/beta signaling	40	1.37e-04	3.49e-01	7.00e-03
Citric acid cycle (TCA cycle)	22	4.86e-03	-3.47e-01	7.11e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	33	6.25e-04	3.44e-01	1.89e-02
Peroxisomal lipid metabolism	24	3.67e-03	-3.43e-01	5.84e-02
Dissolution of Fibrin Clot	10	6.12e-02	3.42e-01	3.22e-01
Mismatch Repair	14	2.70e-02	-3.41e-01	2.05e-01
PECAM1 interactions	10	6.18e-02	3.41e-01	3.24e-01
Zinc transporters	12	4.09e-02	3.41e-01	2.59e-01
Glyoxylate metabolism and glycine degradation	24	4.01e-03	-3.39e-01	6.15e-02
TRAF6 mediated NF-kB activation	21	7.14e-03	3.39e-01	9.57e-02
Regulation of IFNA signaling	12	4.26e-02	3.38e-01	2.66e-01
Translesion synthesis by POLK	15	2.57e-02	-3.33e-01	2.00e-01
Regulation of KIT signaling	15	2.58e-02	3.32e-01	2.00e-01
Processive synthesis on the C-strand of the telomere	18	1.49e-02	-3.32e-01	1.45e-01
Activated NTRK2 signals through FRS2 and FRS3	10	7.01e-02	3.31e-01	3.39e-01
SUMOylation of immune response proteins	11	5.82e-02	3.30e-01	3.18e-01
Cleavage of the damaged purine	10	7.10e-02	-3.30e-01	3.39e-01
Depurination	10	7.10e-02	-3.30e-01	3.39e-01
Recognition and association of DNA glycosylase with site containing an affected purine	10	7.10e-02	-3.30e-01	3.39e-01
The role of Nef in HIV-1 replication and disease pathogenesis	22	7.97e-03	3.27e-01	1.04e-01
Formation of tubulin folding intermediates by CCT/TriC	17	2.00e-02	3.26e-01	1.70e-01
Cytosolic iron-sulfur cluster assembly	10	7.46e-02	3.26e-01	3.45e-01
A tetrasaccharide linker sequence is required for GAG synthesis	19	1.41e-02	3.25e-01	1.44e-01
Assembly of collagen fibrils and other multimeric structures	46	1.55e-04	3.23e-01	7.04e-03
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	24	6.72e-03	3.20e-01	9.10e-02
Metal ion SLC transporters	20	1.43e-02	3.17e-01	1.44e-01
Prolactin receptor signaling	10	8.61e-02	-3.13e-01	3.72e-01
HS-GAG degradation	18	2.19e-02	3.12e-01	1.80e-01
Class I peroxisomal membrane protein import	20	1.59e-02	-3.12e-01	1.49e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	5.28e-02	-3.10e-01	3.00e-01
Biosynthesis of specialized proresolving mediators (SPMs)	14	4.46e-02	-3.10e-01	2.72e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	6.31e-02	3.10e-01	3.25e-01
Defective EXT2 causes exostoses 2	12	6.31e-02	3.10e-01	3.25e-01
MET activates PTK2 signaling	15	3.88e-02	3.08e-01	2.56e-01
HS-GAG biosynthesis	21	1.48e-02	3.07e-01	1.45e-01
Translesion Synthesis by POLH	16	3.38e-02	-3.07e-01	2.35e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	12	6.61e-02	3.06e-01	3.31e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	12	6.61e-02	3.06e-01	3.31e-01
Heparan sulfate/heparin (HS-GAG) metabolism	38	1.23e-03	3.03e-01	2.80e-02
Complex I biogenesis	53	1.54e-04	-3.01e-01	7.04e-03
Meiotic recombination	17	3.23e-02	-3.00e-01	2.31e-01
Peptide ligand-binding receptors	50	2.57e-04	2.99e-01	9.91e-03
Attenuation phase	20	2.07e-02	2.99e-01	1.73e-01
Gluconeogenesis	27	7.51e-03	-2.97e-01	9.87e-02
Mitochondrial translation elongation	83	4.02e-06	-2.93e-01	4.26e-04
Gastrin-CREB signalling pathway via PKC and MAPK	16	4.32e-02	2.92e-01	2.69e-01
O-linked glycosylation of mucins	25	1.16e-02	2.92e-01	1.26e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	11	9.42e-02	-2.92e-01	3.93e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	22	1.86e-02	-2.90e-01	1.60e-01
Transcriptional regulation of granulopoiesis	27	9.67e-03	2.88e-01	1.16e-01
Mitochondrial translation	89	2.96e-06	-2.87e-01	3.77e-04
Glycogen storage diseases	12	8.57e-02	-2.87e-01	3.71e-01
Collagen formation	69	4.24e-05	2.85e-01	2.46e-03
rRNA processing in the mitochondrion	12	8.76e-02	2.85e-01	3.76e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	5.03e-02	2.83e-01	2.87e-01
Mitochondrial translation termination	83	8.91e-06	-2.82e-01	8.73e-04
Mitochondrial translation initiation	83	1.00e-05	-2.81e-01	9.14e-04
MET promotes cell motility	25	1.51e-02	2.81e-01	1.45e-01
Ephrin signaling	17	4.59e-02	2.80e-01	2.76e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	6.11e-02	2.79e-01	3.22e-01
Miscellaneous transport and binding events	17	4.77e-02	2.78e-01	2.76e-01
Interleukin-20 family signaling	13	8.34e-02	2.77e-01	3.65e-01
Interleukin-6 signaling	10	1.33e-01	2.75e-01	4.54e-01
The canonical retinoid cycle in rods (twilight vision)	11	1.16e-01	-2.74e-01	4.28e-01
Class A/1 (Rhodopsin-like receptors)	75	4.31e-05	2.73e-01	2.46e-03
p75NTR signals via NF-kB	14	7.72e-02	2.73e-01	3.49e-01
Chondroitin sulfate biosynthesis	14	7.76e-02	2.73e-01	3.49e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	1.36e-01	-2.72e-01	4.59e-01
Diseases associated with glycosylation precursor biosynthesis	18	4.67e-02	-2.71e-01	2.76e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	11	1.22e-01	2.70e-01	4.38e-01
HIV Transcription Initiation	43	2.30e-03	-2.69e-01	4.32e-02
RNA Polymerase II HIV Promoter Escape	43	2.30e-03	-2.69e-01	4.32e-02
RNA Polymerase II Promoter Escape	43	2.30e-03	-2.69e-01	4.32e-02
RNA Polymerase II Transcription Initiation	43	2.30e-03	-2.69e-01	4.32e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	2.30e-03	-2.69e-01	4.32e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	2.30e-03	-2.69e-01	4.32e-02
Translation of Replicase and Assembly of the Replication Transcription Complex	12	1.07e-01	-2.69e-01	4.10e-01
Telomere C-strand (Lagging Strand) Synthesis	30	1.12e-02	-2.68e-01	1.26e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	1.11e-01	2.66e-01	4.17e-01
Glutamate and glutamine metabolism	10	1.46e-01	2.65e-01	4.75e-01
ROS and RNS production in phagocytes	26	1.97e-02	2.64e-01	1.68e-01
HSF1-dependent transactivation	30	1.23e-02	2.64e-01	1.33e-01
DCC mediated attractive signaling	13	9.95e-02	2.64e-01	4.01e-01
Interleukin-7 signaling	16	6.79e-02	2.64e-01	3.37e-01
Processing of Intronless Pre-mRNAs	17	6.11e-02	2.62e-01	3.22e-01
Scavenging of heme from plasma	10	1.52e-01	-2.61e-01	4.84e-01
FOXO-mediated transcription of cell cycle genes	16	7.10e-02	2.61e-01	3.39e-01
tRNA Aminoacylation	24	2.74e-02	-2.60e-01	2.07e-01
Signaling by NTRK2 (TRKB)	21	3.93e-02	2.60e-01	2.58e-01
Protein localization	139	1.36e-07	-2.60e-01	2.47e-05
Amino acid transport across the plasma membrane	20	4.60e-02	2.58e-01	2.76e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	4.71e-02	2.57e-01	2.76e-01
Extra-nuclear estrogen signaling	60	6.05e-04	2.56e-01	1.88e-02
Respiratory electron transport	92	2.46e-05	-2.55e-01	1.74e-03
O-linked glycosylation	55	1.11e-03	2.54e-01	2.68e-02
MET activates RAP1 and RAC1	10	1.65e-01	2.54e-01	5.06e-01
IRE1alpha activates chaperones	47	2.67e-03	2.53e-01	4.79e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	2.57e-02	2.53e-01	2.00e-01
CASP8 activity is inhibited	10	1.68e-01	-2.52e-01	5.08e-01
Dimerization of procaspase-8	10	1.68e-01	-2.52e-01	5.08e-01
Regulation by c-FLIP	10	1.68e-01	-2.52e-01	5.08e-01
Assembly of active LPL and LIPC lipase complexes	12	1.32e-01	2.51e-01	4.53e-01
Constitutive Signaling by Overexpressed ERBB2	10	1.70e-01	2.51e-01	5.09e-01
Phase 2 - plateau phase	11	1.50e-01	-2.51e-01	4.81e-01
Cytochrome P450 - arranged by substrate type	31	1.61e-02	-2.50e-01	1.49e-01
Regulation of beta-cell development	18	6.75e-02	2.49e-01	3.36e-01
Nicotinamide salvaging	12	1.36e-01	2.49e-01	4.59e-01
Chaperone Mediated Autophagy	15	9.71e-02	2.48e-01	3.98e-01
Metabolism of Angiotensinogen to Angiotensins	12	1.38e-01	2.47e-01	4.60e-01
Regulation of localization of FOXO transcription factors	12	1.40e-01	2.46e-01	4.66e-01
Degradation of the extracellular matrix	65	6.85e-04	2.44e-01	2.03e-02
Polymerase switching on the C-strand of the telomere	23	4.41e-02	-2.43e-01	2.70e-01
Regulation of TP53 Activity through Association with Co-factors	12	1.46e-01	2.42e-01	4.75e-01
Translation of structural proteins	26	3.27e-02	2.42e-01	2.31e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	1.17e-01	2.42e-01	4.28e-01
Transport of bile salts and organic acids, metal ions and amine compounds	39	9.01e-03	2.42e-01	1.12e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	96	4.45e-05	-2.42e-01	2.46e-03
Other interleukin signaling	16	9.46e-02	2.41e-01	3.94e-01
Inflammasomes	16	9.49e-02	2.41e-01	3.94e-01
Unwinding of DNA	11	1.67e-01	2.41e-01	5.08e-01
RHO GTPases Activate WASPs and WAVEs	34	1.52e-02	2.41e-01	1.45e-01
Collagen biosynthesis and modifying enzymes	50	3.28e-03	2.41e-01	5.46e-02
The citric acid (TCA) cycle and respiratory electron transport	142	8.15e-07	-2.40e-01	1.15e-04
Termination of translesion DNA synthesis	27	3.17e-02	-2.39e-01	2.31e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	1.91e-01	2.39e-01	5.40e-01
alpha-linolenic acid (ALA) metabolism	10	1.91e-01	2.39e-01	5.40e-01
Lagging Strand Synthesis	19	7.24e-02	-2.38e-01	3.41e-01
Recognition of DNA damage by PCNA-containing replication complex	25	4.06e-02	-2.37e-01	2.59e-01
Laminin interactions	21	6.13e-02	2.36e-01	3.22e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	50	3.99e-03	-2.36e-01	6.15e-02
IKK complex recruitment mediated by RIP1	17	9.35e-02	2.35e-01	3.92e-01
Dual Incision in GG-NER	38	1.24e-02	-2.35e-01	1.33e-01
Diseases of programmed cell death	19	7.74e-02	2.34e-01	3.49e-01
CS/DS degradation	10	2.01e-01	2.33e-01	5.57e-01
Diseases associated with O-glycosylation of proteins	34	1.86e-02	2.33e-01	1.60e-01
NF-kB is activated and signals survival	11	1.84e-01	2.31e-01	5.30e-01
Base Excision Repair	41	1.05e-02	-2.31e-01	1.23e-01
Regulation of necroptotic cell death	12	1.66e-01	-2.31e-01	5.07e-01
RUNX3 regulates NOTCH signaling	13	1.49e-01	2.31e-01	4.80e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	1.10e-01	2.31e-01	4.17e-01
Signaling by ERBB2 TMD/JMD mutants	15	1.22e-01	2.31e-01	4.38e-01
Peroxisomal protein import	51	4.50e-03	-2.30e-01	6.83e-02
Unfolded Protein Response (UPR)	82	3.26e-04	2.30e-01	1.15e-02
TICAM1, RIP1-mediated IKK complex recruitment	16	1.12e-01	2.29e-01	4.17e-01
Phase 0 - rapid depolarisation	22	6.32e-02	-2.29e-01	3.25e-01
RHO GTPases activate PAKs	20	7.79e-02	-2.28e-01	3.49e-01
XBP1(S) activates chaperone genes	45	8.31e-03	2.28e-01	1.05e-01
RHO GTPases activate IQGAPs	10	2.15e-01	2.26e-01	5.75e-01
N-glycan antennae elongation in the medial/trans-Golgi	18	9.69e-02	2.26e-01	3.98e-01
Dual incision in TC-NER	60	2.48e-03	-2.26e-01	4.51e-02
Maturation of nucleoprotein	10	2.16e-01	2.26e-01	5.76e-01
Keratinization	15	1.31e-01	2.25e-01	4.50e-01
Phase I - Functionalization of compounds	61	2.36e-03	-2.25e-01	4.36e-02
Regulation of TLR by endogenous ligand	12	1.77e-01	-2.25e-01	5.18e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	1.77e-01	2.25e-01	5.18e-01
Chondroitin sulfate/dermatan sulfate metabolism	39	1.53e-02	2.25e-01	1.45e-01
VEGFR2 mediated vascular permeability	26	4.77e-02	2.24e-01	2.76e-01
Signaling by Interleukins	316	9.19e-12	2.24e-01	2.93e-09
Fanconi Anemia Pathway	26	4.82e-02	-2.24e-01	2.77e-01
Glycosaminoglycan metabolism	91	2.56e-04	2.22e-01	9.91e-03
Erythropoietin activates RAS	12	1.85e-01	2.21e-01	5.31e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	18	1.06e-01	2.20e-01	4.08e-01
Neurodegenerative Diseases	18	1.06e-01	2.20e-01	4.08e-01
Regulation of RUNX1 Expression and Activity	17	1.18e-01	2.19e-01	4.28e-01
Ion homeostasis	40	1.67e-02	-2.19e-01	1.51e-01
Leading Strand Synthesis	14	1.57e-01	-2.19e-01	4.91e-01
Polymerase switching	14	1.57e-01	-2.19e-01	4.91e-01
SHC1 events in EGFR signaling	10	2.32e-01	2.18e-01	5.99e-01
Sema3A PAK dependent Axon repulsion	15	1.44e-01	2.18e-01	4.70e-01
Signaling by Leptin	11	2.12e-01	2.18e-01	5.73e-01
GRB2 events in ERBB2 signaling	10	2.34e-01	2.17e-01	6.01e-01
O-glycosylation of TSR domain-containing proteins	25	6.06e-02	2.17e-01	3.22e-01
Antigen processing-Cross presentation	78	1.03e-03	2.15e-01	2.58e-02
PI3K/AKT Signaling in Cancer	70	1.90e-03	2.15e-01	4.05e-02
Signaling by Retinoic Acid	32	3.55e-02	-2.15e-01	2.41e-01
Cell surface interactions at the vascular wall	90	4.45e-04	2.15e-01	1.52e-02
Transcription of the HIV genome	62	3.67e-03	-2.14e-01	5.84e-02
Other semaphorin interactions	17	1.28e-01	2.13e-01	4.46e-01
Scavenging by Class A Receptors	15	1.56e-01	2.12e-01	4.89e-01
Extension of Telomeres	43	1.64e-02	-2.12e-01	1.50e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	1.44e-01	2.11e-01	4.70e-01
Mitochondrial Fatty Acid Beta-Oxidation	31	4.25e-02	-2.11e-01	2.66e-01
Collagen degradation	24	7.54e-02	2.10e-01	3.47e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	59	5.74e-03	-2.08e-01	8.04e-02
Mitochondrial biogenesis	67	3.29e-03	-2.08e-01	5.46e-02
NOTCH3 Intracellular Domain Regulates Transcription	19	1.18e-01	2.07e-01	4.28e-01
Glycogen synthesis	12	2.14e-01	-2.07e-01	5.75e-01
Resolution of Abasic Sites (AP sites)	34	3.69e-02	-2.07e-01	2.47e-01
Fatty acyl-CoA biosynthesis	22	9.34e-02	2.07e-01	3.92e-01
SLC transporter disorders	55	8.20e-03	2.06e-01	1.04e-01
Downregulation of ERBB2 signaling	20	1.11e-01	2.06e-01	4.17e-01
Metabolism of cofactors	18	1.31e-01	-2.06e-01	4.50e-01
Phase II - Conjugation of compounds	60	5.90e-03	-2.06e-01	8.17e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	2.40e-01	2.05e-01	6.04e-01
PERK regulates gene expression	28	6.32e-02	2.03e-01	3.25e-01
Export of Viral Ribonucleoproteins from Nucleus	27	6.83e-02	2.03e-01	3.37e-01
HSF1 activation	22	9.99e-02	2.03e-01	4.01e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	73	2.79e-03	-2.03e-01	4.94e-02
Transcription of E2F targets under negative control by DREAM complex	17	1.48e-01	2.03e-01	4.79e-01
GPVI-mediated activation cascade	28	6.60e-02	2.01e-01	3.31e-01
Transcriptional regulation by RUNX3	87	1.23e-03	2.01e-01	2.80e-02
CTLA4 inhibitory signaling	18	1.41e-01	2.01e-01	4.66e-01
Extracellular matrix organization	213	5.19e-07	2.00e-01	8.27e-05
Defective B3GALTL causes Peters-plus syndrome (PpS)	24	9.00e-02	2.00e-01	3.80e-01
Leishmania infection	147	3.09e-05	2.00e-01	1.97e-03
Telomere Extension By Telomerase	19	1.33e-01	-1.99e-01	4.54e-01
Glycogen metabolism	23	9.87e-02	-1.99e-01	4.01e-01
Lysosome Vesicle Biogenesis	28	6.92e-02	1.99e-01	3.39e-01
Formation of the Early Elongation Complex	31	5.63e-02	-1.98e-01	3.11e-01
Formation of the HIV-1 Early Elongation Complex	31	5.63e-02	-1.98e-01	3.11e-01
Interactions of Rev with host cellular proteins	30	6.07e-02	1.98e-01	3.22e-01
ATF6 (ATF6-alpha) activates chaperones	12	2.36e-01	1.98e-01	6.02e-01
Neutrophil degranulation	341	4.44e-10	1.98e-01	1.13e-07
Signaling by SCF-KIT	39	3.28e-02	1.98e-01	2.31e-01
FCGR3A-mediated phagocytosis	55	1.16e-02	1.97e-01	1.26e-01
Leishmania phagocytosis	55	1.16e-02	1.97e-01	1.26e-01
Parasite infection	55	1.16e-02	1.97e-01	1.26e-01
Basigin interactions	19	1.38e-01	1.97e-01	4.60e-01
G0 and Early G1	20	1.29e-01	1.96e-01	4.48e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	10	2.84e-01	1.96e-01	6.47e-01
RA biosynthesis pathway	13	2.25e-01	-1.94e-01	5.88e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	29	7.03e-02	1.94e-01	3.39e-01
FCGR3A-mediated IL10 synthesis	33	5.41e-02	1.94e-01	3.03e-01
Rev-mediated nuclear export of HIV RNA	29	7.10e-02	1.94e-01	3.39e-01
Sulfur amino acid metabolism	23	1.08e-01	-1.94e-01	4.13e-01
Negative regulation of the PI3K/AKT network	76	3.59e-03	1.93e-01	5.84e-02
Intra-Golgi traffic	40	3.48e-02	1.93e-01	2.41e-01
Biological oxidations	125	2.01e-04	-1.93e-01	8.54e-03
NGF-stimulated transcription	32	5.91e-02	1.93e-01	3.20e-01
Constitutive Signaling by Aberrant PI3K in Cancer	43	2.90e-02	1.93e-01	2.14e-01
RUNX2 regulates bone development	25	9.61e-02	1.92e-01	3.97e-01
AKT phosphorylates targets in the nucleus	10	2.93e-01	1.92e-01	6.56e-01
Muscle contraction	132	1.45e-04	-1.92e-01	7.04e-03
ATF4 activates genes in response to endoplasmic reticulum stress	24	1.06e-01	1.91e-01	4.08e-01
Nuclear Pore Complex (NPC) Disassembly	27	8.72e-02	1.90e-01	3.75e-01
Degradation of cysteine and homocysteine	13	2.35e-01	-1.90e-01	6.02e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	14	2.19e-01	1.90e-01	5.78e-01
Bile acid and bile salt metabolism	22	1.24e-01	-1.90e-01	4.38e-01
Recycling pathway of L1	23	1.17e-01	1.89e-01	4.28e-01
Regulation of actin dynamics for phagocytic cup formation	57	1.40e-02	1.88e-01	1.43e-01
Pre-NOTCH Transcription and Translation	32	6.53e-02	1.88e-01	3.31e-01
EPHB-mediated forward signaling	32	6.56e-02	1.88e-01	3.31e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	15	2.07e-01	1.88e-01	5.65e-01
Synthesis of very long-chain fatty acyl-CoAs	12	2.59e-01	1.88e-01	6.23e-01
Meiosis	39	4.38e-02	-1.87e-01	2.70e-01
Signaling by FGFR2 IIIa TM	16	1.97e-01	-1.87e-01	5.49e-01
ADP signalling through P2Y purinoceptor 12	14	2.28e-01	1.86e-01	5.93e-01
EPHA-mediated growth cone collapse	14	2.28e-01	-1.86e-01	5.93e-01
Antimicrobial peptides	10	3.09e-01	1.86e-01	6.72e-01
Vpr-mediated nuclear import of PICs	28	8.93e-02	1.86e-01	3.78e-01
Postmitotic nuclear pore complex (NPC) reformation	24	1.16e-01	1.86e-01	4.28e-01
Insulin processing	18	1.75e-01	-1.85e-01	5.15e-01
Formation of TC-NER Pre-Incision Complex	49	2.55e-02	-1.85e-01	2.00e-01
Retrograde neurotrophin signalling	12	2.69e-01	1.84e-01	6.32e-01
Activation of GABAB receptors	26	1.04e-01	1.84e-01	4.08e-01
GABA B receptor activation	26	1.04e-01	1.84e-01	4.08e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	33	6.71e-02	-1.84e-01	3.35e-01
p75NTR recruits signalling complexes	11	2.91e-01	1.84e-01	6.56e-01
RNA Pol II CTD phosphorylation and interaction with CE	25	1.12e-01	-1.84e-01	4.17e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	25	1.12e-01	-1.84e-01	4.17e-01
Signaling by Non-Receptor Tyrosine Kinases	42	4.04e-02	1.83e-01	2.59e-01
Signaling by PTK6	42	4.04e-02	1.83e-01	2.59e-01
Carboxyterminal post-translational modifications of tubulin	23	1.29e-01	1.83e-01	4.48e-01
SUMOylation of DNA replication proteins	36	5.83e-02	1.82e-01	3.18e-01
mRNA Capping	27	1.02e-01	-1.82e-01	4.06e-01
Synthesis of PC	22	1.42e-01	-1.81e-01	4.69e-01
Synthesis of bile acids and bile salts	19	1.74e-01	-1.80e-01	5.15e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	69	9.84e-03	1.80e-01	1.17e-01
FGFR2 mutant receptor activation	19	1.75e-01	-1.80e-01	5.15e-01
Diseases associated with glycosaminoglycan metabolism	34	7.20e-02	1.78e-01	3.41e-01
Synthesis, secretion, and deacylation of Ghrelin	12	2.88e-01	-1.77e-01	6.52e-01
HDMs demethylate histones	21	1.61e-01	1.77e-01	5.00e-01
Signaling by cytosolic FGFR1 fusion mutants	18	1.98e-01	-1.75e-01	5.50e-01
Glycogen breakdown (glycogenolysis)	14	2.56e-01	-1.75e-01	6.22e-01
NEP/NS2 Interacts with the Cellular Export Machinery	26	1.23e-01	1.75e-01	4.38e-01
Elastic fibre formation	35	7.43e-02	1.74e-01	3.45e-01
Interleukin-1 family signaling	109	1.72e-03	1.74e-01	3.78e-02
ATF6 (ATF6-alpha) activates chaperone genes	10	3.44e-01	1.73e-01	7.12e-01
Telomere Maintenance	56	2.67e-02	-1.71e-01	2.04e-01
Glutathione synthesis and recycling	10	3.49e-01	1.71e-01	7.14e-01
SUMOylation of SUMOylation proteins	28	1.17e-01	1.71e-01	4.28e-01
Cleavage of the damaged pyrimidine	14	2.69e-01	-1.71e-01	6.32e-01
Depyrimidination	14	2.69e-01	-1.71e-01	6.32e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	2.69e-01	-1.71e-01	6.32e-01
FRS-mediated FGFR3 signaling	12	3.08e-01	1.70e-01	6.72e-01
Nuclear import of Rev protein	27	1.27e-01	1.70e-01	4.43e-01
Cytokine Signaling in Immune system	589	3.40e-12	1.70e-01	1.44e-09
Nonhomologous End-Joining (NHEJ)	31	1.02e-01	-1.70e-01	4.06e-01
Signal transduction by L1	21	1.78e-01	1.70e-01	5.19e-01
Inhibition of DNA recombination at telomere	19	2.02e-01	-1.69e-01	5.57e-01
Interferon Signaling	134	7.62e-04	1.69e-01	2.11e-02
Glutathione conjugation	28	1.22e-01	-1.69e-01	4.38e-01
Prostacyclin signalling through prostacyclin receptor	13	2.93e-01	1.69e-01	6.56e-01
HDR through Single Strand Annealing (SSA)	31	1.05e-01	-1.68e-01	4.08e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	21	1.83e-01	-1.68e-01	5.30e-01
Metalloprotease DUBs	15	2.62e-01	-1.67e-01	6.25e-01
mRNA Splicing - Minor Pathway	47	4.74e-02	-1.67e-01	2.76e-01
Voltage gated Potassium channels	16	2.47e-01	1.67e-01	6.12e-01
Nucleobase biosynthesis	15	2.62e-01	1.67e-01	6.25e-01
Mucopolysaccharidoses	11	3.40e-01	1.66e-01	7.07e-01
Acyl chain remodelling of PS	12	3.21e-01	1.66e-01	6.84e-01
eNOS activation	11	3.42e-01	1.66e-01	7.09e-01
Nephrin family interactions	19	2.13e-01	-1.65e-01	5.74e-01
Regulation of TP53 Activity through Phosphorylation	76	1.29e-02	-1.65e-01	1.37e-01
Signaling by PDGFR in disease	20	2.02e-01	1.65e-01	5.57e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	24	1.63e-01	-1.65e-01	5.03e-01
Interferon gamma signaling	55	3.52e-02	1.64e-01	2.41e-01
Hyaluronan uptake and degradation	10	3.69e-01	1.64e-01	7.32e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	58	3.18e-02	1.63e-01	2.31e-01
Intrinsic Pathway of Fibrin Clot Formation	10	3.73e-01	-1.63e-01	7.36e-01
Reproduction	45	5.93e-02	-1.63e-01	3.20e-01
Transport of Ribonucleoproteins into the Host Nucleus	26	1.54e-01	1.62e-01	4.87e-01
Peptide chain elongation	47	5.58e-02	1.61e-01	3.10e-01
Anti-inflammatory response favouring Leishmania parasite infection	76	1.51e-02	1.61e-01	1.45e-01
Leishmania parasite growth and survival	76	1.51e-02	1.61e-01	1.45e-01
Interconversion of nucleotide di- and triphosphates	22	1.91e-01	1.61e-01	5.40e-01
Nitric oxide stimulates guanylate cyclase	15	2.81e-01	1.61e-01	6.46e-01
PKA activation in glucagon signalling	15	2.83e-01	1.60e-01	6.47e-01
Formation of HIV elongation complex in the absence of HIV Tat	39	8.41e-02	-1.60e-01	3.67e-01
Collagen chain trimerization	34	1.07e-01	1.60e-01	4.10e-01
Detoxification of Reactive Oxygen Species	29	1.38e-01	1.59e-01	4.60e-01
Growth hormone receptor signaling	18	2.43e-01	1.59e-01	6.09e-01
GAB1 signalosome	13	3.24e-01	1.58e-01	6.86e-01
PKA-mediated phosphorylation of CREB	18	2.46e-01	1.58e-01	6.10e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	21	2.11e-01	1.58e-01	5.72e-01
Signaling by NOTCH2	25	1.73e-01	1.58e-01	5.14e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	33	1.19e-01	1.57e-01	4.29e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.05e-01	1.56e-01	4.08e-01
Base-Excision Repair, AP Site Formation	16	2.80e-01	-1.56e-01	6.45e-01
EGFR downregulation	23	1.97e-01	1.55e-01	5.50e-01
Synthesis of PE	11	3.77e-01	-1.54e-01	7.37e-01
Frs2-mediated activation	11	3.77e-01	1.54e-01	7.37e-01
COPI-independent Golgi-to-ER retrograde traffic	27	1.67e-01	-1.54e-01	5.08e-01
DAP12 interactions	23	2.05e-01	1.53e-01	5.61e-01
IL-6-type cytokine receptor ligand interactions	11	3.81e-01	-1.53e-01	7.41e-01
Non-integrin membrane-ECM interactions	39	9.97e-02	1.52e-01	4.01e-01
Potential therapeutics for SARS	34	1.26e-01	1.52e-01	4.43e-01
ER-Phagosome pathway	64	3.62e-02	1.52e-01	2.44e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	3.64e-01	1.51e-01	7.32e-01
RNA Polymerase II Pre-transcription Events	72	2.68e-02	-1.51e-01	2.04e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	37	1.13e-01	-1.51e-01	4.17e-01
HIV Transcription Elongation	37	1.13e-01	-1.51e-01	4.17e-01
Tat-mediated elongation of the HIV-1 transcript	37	1.13e-01	-1.51e-01	4.17e-01
Inactivation, recovery and regulation of the phototransduction cascade	12	3.66e-01	-1.51e-01	7.32e-01
The phototransduction cascade	12	3.66e-01	-1.51e-01	7.32e-01
Semaphorin interactions	58	4.76e-02	1.51e-01	2.76e-01
ESR-mediated signaling	131	3.00e-03	1.51e-01	5.16e-02
Defects in cobalamin (B12) metabolism	10	4.10e-01	-1.50e-01	7.75e-01
Signaling by PDGF	49	6.88e-02	1.50e-01	3.38e-01
Signaling by NOTCH3	40	1.01e-01	1.50e-01	4.03e-01
Pyruvate metabolism	26	1.86e-01	-1.50e-01	5.31e-01
FGFR1 mutant receptor activation	25	1.95e-01	-1.50e-01	5.46e-01
G beta:gamma signalling through PI3Kgamma	19	2.59e-01	1.50e-01	6.23e-01
Nucleotide Excision Repair	103	9.12e-03	-1.49e-01	1.12e-01
Global Genome Nucleotide Excision Repair (GG-NER)	79	2.26e-02	-1.49e-01	1.83e-01
Telomere C-strand synthesis initiation	12	3.75e-01	-1.48e-01	7.37e-01
Platelet sensitization by LDL	15	3.23e-01	1.48e-01	6.85e-01
Ovarian tumor domain proteases	32	1.50e-01	1.47e-01	4.81e-01
GPCR ligand binding	120	5.53e-03	1.47e-01	7.83e-02
Signaling by Erythropoietin	23	2.23e-01	1.47e-01	5.87e-01
Immune System	1389	5.98e-19	1.47e-01	7.62e-16
Branched-chain amino acid catabolism	20	2.57e-01	-1.46e-01	6.22e-01
Interactions of Vpr with host cellular proteins	30	1.66e-01	1.46e-01	5.08e-01
Fcgamma receptor (FCGR) dependent phagocytosis	80	2.52e-02	1.45e-01	1.99e-01
NS1 Mediated Effects on Host Pathways	31	1.65e-01	1.44e-01	5.06e-01
Hyaluronan metabolism	13	3.74e-01	1.42e-01	7.37e-01
Signaling by EGFR	42	1.11e-01	1.42e-01	4.17e-01
Cardiac conduction	72	3.74e-02	-1.42e-01	2.49e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	37	1.35e-01	1.42e-01	4.59e-01
Aggrephagy	17	3.13e-01	-1.41e-01	6.74e-01
Signaling by BMP	23	2.41e-01	1.41e-01	6.04e-01
Activation of AMPK downstream of NMDARs	10	4.40e-01	-1.41e-01	7.93e-01
Reduction of cytosolic Ca++ levels	10	4.40e-01	-1.41e-01	7.93e-01
Signal amplification	24	2.33e-01	1.41e-01	6.00e-01
Protein ubiquitination	55	7.27e-02	-1.40e-01	3.41e-01
SUMOylation of ubiquitinylation proteins	32	1.71e-01	1.40e-01	5.11e-01
Keratan sulfate biosynthesis	21	2.70e-01	1.39e-01	6.32e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	26	2.22e-01	-1.38e-01	5.86e-01
G-protein activation	15	3.54e-01	1.38e-01	7.20e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	2.51e-01	1.38e-01	6.19e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	3.39e-01	1.38e-01	7.07e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	3.39e-01	1.38e-01	7.07e-01
Translation	219	4.54e-04	-1.38e-01	1.52e-02
ECM proteoglycans	41	1.27e-01	1.38e-01	4.43e-01
Trafficking of GluR2-containing AMPA receptors	11	4.29e-01	1.38e-01	7.89e-01
Innate Immune System	704	1.00e-09	1.37e-01	2.13e-07
WNT ligand biogenesis and trafficking	12	4.13e-01	-1.37e-01	7.75e-01
Signalling to RAS	17	3.31e-01	1.36e-01	6.96e-01
Transcriptional regulation of white adipocyte differentiation	77	3.94e-02	1.36e-01	2.58e-01
Syndecan interactions	19	3.07e-01	1.35e-01	6.72e-01
Diseases of carbohydrate metabolism	28	2.18e-01	-1.35e-01	5.78e-01
SUMOylation of RNA binding proteins	40	1.43e-01	1.34e-01	4.69e-01
Cell-Cell communication	78	4.15e-02	1.34e-01	2.62e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	57	8.16e-02	1.33e-01	3.61e-01
HDR through Homologous Recombination (HRR)	50	1.04e-01	-1.33e-01	4.08e-01
Transcriptional regulation by RUNX2	97	2.41e-02	1.33e-01	1.92e-01
Chromosome Maintenance	71	5.36e-02	-1.33e-01	3.03e-01
Negative regulation of MET activity	16	3.59e-01	1.33e-01	7.27e-01
E3 ubiquitin ligases ubiquitinate target proteins	38	1.60e-01	-1.32e-01	4.99e-01
Signaling by NODAL	13	4.11e-01	1.32e-01	7.75e-01
Signaling by ERBB2 in Cancer	19	3.21e-01	1.32e-01	6.84e-01
Activation of the AP-1 family of transcription factors	10	4.73e-01	-1.31e-01	8.14e-01
Interleukin-2 family signaling	29	2.24e-01	1.31e-01	5.88e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	12	4.37e-01	1.30e-01	7.90e-01
RHO GTPases Activate ROCKs	19	3.29e-01	-1.29e-01	6.95e-01
RMTs methylate histone arginines	28	2.37e-01	1.29e-01	6.03e-01
Nuclear Envelope (NE) Reassembly	59	8.90e-02	1.28e-01	3.78e-01
trans-Golgi Network Vesicle Budding	64	7.66e-02	1.28e-01	3.49e-01
Golgi Cisternae Pericentriolar Stack Reorganization	10	4.83e-01	1.28e-01	8.17e-01
Regulation of TP53 Expression and Degradation	31	2.19e-01	1.28e-01	5.78e-01
Amyloid fiber formation	36	1.86e-01	1.27e-01	5.31e-01
Nuclear Envelope Breakdown	42	1.54e-01	1.27e-01	4.87e-01
Regulation of innate immune responses to cytosolic DNA	10	4.88e-01	-1.27e-01	8.21e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	2.84e-01	-1.26e-01	6.47e-01
Selenocysteine synthesis	50	1.23e-01	1.26e-01	4.38e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	25	2.76e-01	1.26e-01	6.40e-01
CD28 co-stimulation	28	2.51e-01	1.25e-01	6.19e-01
Dopamine Neurotransmitter Release Cycle	12	4.52e-01	-1.25e-01	7.99e-01
Synthesis of PA	22	3.09e-01	1.25e-01	6.72e-01
Gap junction trafficking	13	4.35e-01	-1.25e-01	7.90e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	21	3.22e-01	-1.25e-01	6.85e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	37	1.89e-01	1.25e-01	5.38e-01
Energy dependent regulation of mTOR by LKB1-AMPK	29	2.45e-01	-1.25e-01	6.10e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	51	1.25e-01	1.24e-01	4.38e-01
Ca-dependent events	32	2.24e-01	1.24e-01	5.88e-01
Transcriptional Regulation by E2F6	30	2.42e-01	-1.23e-01	6.07e-01
Viral mRNA Translation	47	1.44e-01	1.23e-01	4.70e-01
Generation of second messenger molecules	14	4.25e-01	1.23e-01	7.85e-01
Influenza Infection	101	3.29e-02	1.23e-01	2.31e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	10	5.01e-01	-1.23e-01	8.30e-01
Regulation of IFNG signaling	13	4.43e-01	1.23e-01	7.94e-01
Transport of Mature mRNA Derived from an Intronless Transcript	36	2.04e-01	1.23e-01	5.59e-01
BBSome-mediated cargo-targeting to cilium	20	3.43e-01	-1.22e-01	7.11e-01
HIV elongation arrest and recovery	27	2.72e-01	-1.22e-01	6.34e-01
Pausing and recovery of HIV elongation	27	2.72e-01	-1.22e-01	6.34e-01
Processing of DNA double-strand break ends	50	1.36e-01	-1.22e-01	4.59e-01
Cellular response to heat stress	84	5.40e-02	1.22e-01	3.03e-01
Activation of BAD and translocation to mitochondria	14	4.31e-01	1.22e-01	7.89e-01
DARPP-32 events	21	3.35e-01	-1.22e-01	7.04e-01
Interleukin-12 family signaling	40	1.84e-01	1.21e-01	5.30e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	4.17e-01	-1.21e-01	7.75e-01
Myogenesis	26	2.86e-01	-1.21e-01	6.49e-01
SUMOylation of DNA methylation proteins	16	4.03e-01	1.21e-01	7.75e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	25	2.96e-01	1.21e-01	6.59e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	25	2.96e-01	1.21e-01	6.59e-01
Prolonged ERK activation events	13	4.52e-01	1.20e-01	7.99e-01
CaM pathway	30	2.54e-01	1.20e-01	6.20e-01
Calmodulin induced events	30	2.54e-01	1.20e-01	6.20e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	12	4.70e-01	1.20e-01	8.14e-01
FRS-mediated FGFR1 signaling	13	4.53e-01	1.20e-01	8.00e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	4.37e-01	1.20e-01	7.90e-01
G1/S-Specific Transcription	22	3.31e-01	1.20e-01	6.96e-01
Keratan sulfate/keratin metabolism	26	2.93e-01	1.19e-01	6.56e-01
Eukaryotic Translation Elongation	51	1.41e-01	1.19e-01	4.66e-01
Depolymerisation of the Nuclear Lamina	12	4.75e-01	1.19e-01	8.14e-01
Formation of Incision Complex in GG-NER	40	1.94e-01	-1.19e-01	5.44e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	76	7.47e-02	-1.18e-01	3.45e-01
Resolution of D-Loop Structures	22	3.37e-01	-1.18e-01	7.06e-01
Cyclin E associated events during G1/S transition	73	8.19e-02	1.18e-01	3.61e-01
Mitochondrial iron-sulfur cluster biogenesis	12	4.80e-01	1.18e-01	8.14e-01
Ion transport by P-type ATPases	38	2.10e-01	-1.18e-01	5.70e-01
Cyclin A:Cdk2-associated events at S phase entry	75	7.88e-02	1.18e-01	3.51e-01
TRAF3-dependent IRF activation pathway	13	4.64e-01	-1.17e-01	8.09e-01
Costimulation by the CD28 family	45	1.74e-01	1.17e-01	5.15e-01
Presynaptic phase of homologous DNA pairing and strand exchange	30	2.67e-01	-1.17e-01	6.32e-01
Selenoamino acid metabolism	64	1.06e-01	1.17e-01	4.08e-01
DNA Repair	240	1.91e-03	-1.17e-01	4.05e-02
DNA Double-Strand Break Repair	107	3.79e-02	-1.16e-01	2.52e-01
Tight junction interactions	11	5.04e-01	-1.16e-01	8.33e-01
B-WICH complex positively regulates rRNA expression	31	2.63e-01	1.16e-01	6.27e-01
Homology Directed Repair	80	7.32e-02	-1.16e-01	3.41e-01
Metabolism of steroid hormones	13	4.70e-01	1.16e-01	8.14e-01
Host Interactions of HIV factors	106	4.00e-02	1.16e-01	2.59e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	22	3.48e-01	1.16e-01	7.14e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	25	3.18e-01	-1.15e-01	6.83e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	4.11e-01	-1.15e-01	7.75e-01
Signaling by NTRKs	117	3.21e-02	1.15e-01	2.31e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	77	8.30e-02	1.14e-01	3.65e-01
Cell junction organization	47	1.76e-01	1.14e-01	5.17e-01
Vitamin B5 (pantothenate) metabolism	15	4.44e-01	1.14e-01	7.94e-01
FOXO-mediated transcription of cell death genes	14	4.60e-01	1.14e-01	8.07e-01
Senescence-Associated Secretory Phenotype (SASP)	44	1.92e-01	1.14e-01	5.40e-01
Binding and Uptake of Ligands by Scavenger Receptors	34	2.52e-01	1.14e-01	6.20e-01
Budding and maturation of HIV virion	23	3.46e-01	-1.13e-01	7.14e-01
SHC-mediated cascade:FGFR3	10	5.35e-01	1.13e-01	8.39e-01
Platelet calcium homeostasis	21	3.70e-01	-1.13e-01	7.32e-01
GABA receptor activation	29	2.94e-01	1.13e-01	6.56e-01
Hemostasis	414	9.49e-05	1.13e-01	5.04e-03
rRNA processing	153	1.71e-02	1.12e-01	1.52e-01
Interleukin-12 signaling	35	2.53e-01	1.12e-01	6.20e-01
Smooth Muscle Contraction	34	2.62e-01	-1.11e-01	6.25e-01
Signaling by FGFR2 in disease	29	3.02e-01	-1.11e-01	6.64e-01
Metabolic disorders of biological oxidation enzymes	18	4.16e-01	-1.11e-01	7.75e-01
SLC-mediated transmembrane transport	133	2.80e-02	1.11e-01	2.10e-01
G beta:gamma signalling through CDC42	14	4.75e-01	-1.10e-01	8.14e-01
DNA Damage Bypass	40	2.28e-01	-1.10e-01	5.93e-01
Formation of the cornified envelope	11	5.28e-01	1.10e-01	8.39e-01
Diseases of glycosylation	101	5.81e-02	1.09e-01	3.18e-01
Activated NOTCH1 Transmits Signal to the Nucleus	25	3.46e-01	1.09e-01	7.14e-01
PINK1-PRKN Mediated Mitophagy	17	4.39e-01	-1.08e-01	7.93e-01
Homologous DNA Pairing and Strand Exchange	31	2.96e-01	-1.08e-01	6.59e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	5.37e-01	-1.07e-01	8.39e-01
Regulation of RUNX3 expression and activity	47	2.03e-01	1.07e-01	5.59e-01
Signaling by ERBB2 KD Mutants	18	4.31e-01	1.07e-01	7.89e-01
Disorders of transmembrane transporters	115	4.78e-02	1.07e-01	2.76e-01
Factors involved in megakaryocyte development and platelet production	81	9.74e-02	1.07e-01	3.98e-01
Removal of the Flap Intermediate	13	5.06e-01	-1.07e-01	8.34e-01
Calnexin/calreticulin cycle	23	3.77e-01	1.07e-01	7.37e-01
PI-3K cascade:FGFR4	11	5.41e-01	-1.06e-01	8.41e-01
Neurotransmitter receptors and postsynaptic signal transmission	102	6.37e-02	1.06e-01	3.26e-01
Transmission across Chemical Synapses	132	3.56e-02	1.06e-01	2.41e-01
Plasma lipoprotein clearance	27	3.40e-01	-1.06e-01	7.07e-01
RORA activates gene expression	17	4.50e-01	-1.06e-01	7.99e-01
Glutamate Neurotransmitter Release Cycle	12	5.26e-01	1.06e-01	8.39e-01
Pausing and recovery of Tat-mediated HIV elongation	25	3.61e-01	-1.06e-01	7.27e-01
Tat-mediated HIV elongation arrest and recovery	25	3.61e-01	-1.06e-01	7.27e-01
Phosphorylation of the APC/C	17	4.56e-01	-1.05e-01	8.02e-01
Estrogen-dependent gene expression	73	1.23e-01	1.05e-01	4.38e-01
Transcriptional regulation by RUNX1	148	2.87e-02	1.04e-01	2.14e-01
Transcriptional activation of mitochondrial biogenesis	48	2.13e-01	-1.04e-01	5.74e-01
Pre-NOTCH Expression and Processing	47	2.18e-01	1.04e-01	5.78e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	5.51e-01	1.04e-01	8.48e-01
Influenza Viral RNA Transcription and Replication	86	9.71e-02	1.04e-01	3.98e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	17	4.60e-01	-1.03e-01	8.07e-01
SARS-CoV Infections	76	1.20e-01	1.03e-01	4.33e-01
Gene Silencing by RNA	55	1.86e-01	1.03e-01	5.31e-01
TRAF6 mediated IRF7 activation	15	4.93e-01	-1.02e-01	8.24e-01
PKA activation	16	4.79e-01	1.02e-01	8.14e-01
Downregulation of TGF-beta receptor signaling	24	3.87e-01	1.02e-01	7.51e-01
Interleukin-1 signaling	87	1.01e-01	1.02e-01	4.05e-01
RUNX2 regulates osteoblast differentiation	19	4.43e-01	1.02e-01	7.94e-01
VLDLR internalisation and degradation	11	5.60e-01	-1.02e-01	8.49e-01
Synthesis of IP3 and IP4 in the cytosol	21	4.22e-01	1.01e-01	7.81e-01
Regulation of TP53 Degradation	30	3.40e-01	1.01e-01	7.07e-01
SRP-dependent cotranslational protein targeting to membrane	68	1.52e-01	1.01e-01	4.84e-01
Post NMDA receptor activation events	44	2.49e-01	1.01e-01	6.15e-01
Pentose phosphate pathway	13	5.30e-01	1.01e-01	8.39e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	53	2.06e-01	1.01e-01	5.63e-01
Regulation of TP53 Activity	136	4.39e-02	-1.00e-01	2.70e-01
Cell death signalling via NRAGE, NRIF and NADE	63	1.69e-01	1.00e-01	5.09e-01
Signaling by ERBB2	39	2.80e-01	1.00e-01	6.45e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	24	3.99e-01	9.94e-02	7.72e-01
Interleukin receptor SHC signaling	20	4.43e-01	9.91e-02	7.94e-01
Interaction between L1 and Ankyrins	15	5.07e-01	-9.90e-02	8.34e-01
Toll Like Receptor 4 (TLR4) Cascade	112	7.20e-02	9.86e-02	3.41e-01
EPH-Ephrin signaling	77	1.37e-01	9.82e-02	4.60e-01
TICAM1-dependent activation of IRF3/IRF7	10	5.91e-01	9.82e-02	8.62e-01
Synthesis of substrates in N-glycan biosythesis	54	2.13e-01	-9.81e-02	5.74e-01
Glucagon signaling in metabolic regulation	24	4.08e-01	9.76e-02	7.75e-01
Signaling by Receptor Tyrosine Kinases	391	1.03e-03	9.74e-02	2.58e-02
Response of Mtb to phagocytosis	20	4.51e-01	-9.74e-02	7.99e-01
Mitotic Prophase	70	1.60e-01	9.72e-02	4.99e-01
rRNA processing in the nucleus and cytosol	141	4.77e-02	9.69e-02	2.76e-01
ERKs are inactivated	13	5.46e-01	-9.69e-02	8.44e-01
Signaling by ERBB2 ECD mutants	15	5.17e-01	9.67e-02	8.39e-01
Major pathway of rRNA processing in the nucleolus and cytosol	132	5.57e-02	9.67e-02	3.10e-01
Potassium Channels	41	2.86e-01	9.64e-02	6.49e-01
Neurotransmitter release cycle	24	4.15e-01	9.61e-02	7.75e-01
Transcriptional Regulation by MECP2	43	2.76e-01	-9.61e-02	6.40e-01
Activation of NMDA receptors and postsynaptic events	52	2.31e-01	9.60e-02	5.99e-01
Neuronal System	190	2.31e-02	9.60e-02	1.86e-01
Gap junction trafficking and regulation	15	5.22e-01	-9.55e-02	8.39e-01
G2/M DNA damage checkpoint	50	2.44e-01	-9.53e-02	6.09e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	19	4.72e-01	9.53e-02	8.14e-01
L1CAM interactions	70	1.70e-01	9.50e-02	5.09e-01
CD28 dependent PI3K/Akt signaling	19	4.74e-01	9.50e-02	8.14e-01
EPH-ephrin mediated repulsion of cells	38	3.12e-01	9.48e-02	6.74e-01
Nicotinate metabolism	22	4.43e-01	9.46e-02	7.94e-01
Signaling by KIT in disease	19	4.79e-01	9.39e-02	8.14e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	4.79e-01	9.39e-02	8.14e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	44	2.82e-01	9.39e-02	6.47e-01
Regulation of signaling by CBL	18	4.91e-01	9.39e-02	8.23e-01
Regulation of FOXO transcriptional activity by acetylation	10	6.07e-01	9.39e-02	8.69e-01
Acyl chain remodelling of PE	13	5.58e-01	9.38e-02	8.49e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	5.91e-01	9.37e-02	8.62e-01
APC/C:Cdc20 mediated degradation of Cyclin B	19	4.80e-01	-9.36e-02	8.14e-01
COPI-dependent Golgi-to-ER retrograde traffic	59	2.14e-01	9.36e-02	5.75e-01
Regulation of MECP2 expression and activity	26	4.11e-01	-9.33e-02	7.75e-01
NCAM signaling for neurite out-growth	42	2.97e-01	9.31e-02	6.59e-01
NRAGE signals death through JNK	49	2.61e-01	9.30e-02	6.25e-01
Late Phase of HIV Life Cycle	117	8.46e-02	-9.25e-02	3.68e-01
FRS-mediated FGFR2 signaling	13	5.64e-01	9.24e-02	8.50e-01
G alpha (s) signalling events	67	1.92e-01	9.23e-02	5.40e-01
ADORA2B mediated anti-inflammatory cytokines production	48	2.70e-01	9.22e-02	6.32e-01
Transport of the SLBP Dependant Mature mRNA	30	3.82e-01	9.22e-02	7.44e-01
Cytosolic sulfonation of small molecules	15	5.37e-01	-9.22e-02	8.39e-01
Nuclear Events (kinase and transcription factor activation)	54	2.44e-01	9.17e-02	6.09e-01
Uptake and actions of bacterial toxins	22	4.58e-01	9.14e-02	8.05e-01
Metabolism of nucleotides	80	1.62e-01	9.05e-02	5.03e-01
PRC2 methylates histones and DNA	14	5.59e-01	-9.02e-02	8.49e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	5.23e-01	8.96e-02	8.39e-01
Olfactory Signaling Pathway	11	6.07e-01	-8.95e-02	8.69e-01
Processive synthesis on the lagging strand	14	5.63e-01	-8.93e-02	8.50e-01
Biotin transport and metabolism	11	6.10e-01	-8.88e-02	8.73e-01
Signaling by TGFB family members	87	1.53e-01	8.88e-02	4.85e-01
Signaling by MET	55	2.56e-01	8.87e-02	6.22e-01
p75 NTR receptor-mediated signalling	80	1.71e-01	8.86e-02	5.11e-01
RNA Polymerase III Transcription Termination	22	4.72e-01	-8.86e-02	8.14e-01
PIP3 activates AKT signaling	221	2.39e-02	8.85e-02	1.92e-01
Transport of the SLBP independent Mature mRNA	29	4.11e-01	8.83e-02	7.75e-01
Eukaryotic Translation Termination	49	2.86e-01	8.82e-02	6.49e-01
p38MAPK events	12	5.98e-01	8.79e-02	8.65e-01
Cross-presentation of soluble exogenous antigens (endosomes)	43	3.20e-01	8.78e-02	6.84e-01
Regulation of HSF1-mediated heat shock response	67	2.15e-01	8.77e-02	5.75e-01
Elevation of cytosolic Ca2+ levels	11	6.15e-01	-8.76e-02	8.78e-01
RIPK1-mediated regulated necrosis	14	5.72e-01	-8.74e-02	8.56e-01
Regulated Necrosis	14	5.72e-01	-8.74e-02	8.56e-01
Endogenous sterols	14	5.72e-01	8.72e-02	8.56e-01
Surfactant metabolism	12	6.01e-01	8.71e-02	8.65e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	19	5.11e-01	-8.71e-02	8.35e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	5.11e-01	-8.71e-02	8.35e-01
Notch-HLH transcription pathway	25	4.51e-01	8.71e-02	7.99e-01
Intracellular signaling by second messengers	256	1.71e-02	8.70e-02	1.52e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	24	4.61e-01	8.70e-02	8.07e-01
Defects in vitamin and cofactor metabolism	18	5.27e-01	-8.62e-02	8.39e-01
G-protein mediated events	44	3.24e-01	8.60e-02	6.86e-01
Signalling to ERKs	30	4.15e-01	8.60e-02	7.75e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	6.38e-01	-8.58e-02	8.88e-01
STING mediated induction of host immune responses	10	6.39e-01	-8.57e-02	8.88e-01
HIV Life Cycle	127	9.86e-02	-8.51e-02	4.01e-01
Signaling by VEGF	96	1.52e-01	8.48e-02	4.84e-01
Caspase activation via Death Receptors in the presence of ligand	13	6.00e-01	-8.41e-02	8.65e-01
Formation of RNA Pol II elongation complex	51	3.00e-01	-8.40e-02	6.61e-01
RNA Polymerase II Transcription Elongation	51	3.00e-01	-8.40e-02	6.61e-01
Transcriptional regulation of pluripotent stem cells	13	6.02e-01	-8.36e-02	8.65e-01
VxPx cargo-targeting to cilium	17	5.52e-01	8.33e-02	8.48e-01
Activation of NF-kappaB in B cells	57	2.79e-01	8.31e-02	6.44e-01
PLC beta mediated events	43	3.50e-01	8.24e-02	7.15e-01
mRNA decay by 3' to 5' exoribonuclease	15	5.81e-01	8.24e-02	8.58e-01
Processing of Capped Intronless Pre-mRNA	25	4.77e-01	8.22e-02	8.14e-01
TP53 Regulates Transcription of Cell Cycle Genes	39	3.75e-01	8.21e-02	7.37e-01
Signaling by Hippo	18	5.48e-01	8.18e-02	8.47e-01
RNA Polymerase III Chain Elongation	17	5.60e-01	-8.18e-02	8.49e-01
Chaperonin-mediated protein folding	70	2.38e-01	8.17e-02	6.04e-01
TP53 Regulates Transcription of DNA Repair Genes	52	3.09e-01	-8.16e-02	6.72e-01
Purine ribonucleoside monophosphate biosynthesis	12	6.25e-01	8.15e-02	8.84e-01
Activation of BH3-only proteins	26	4.72e-01	8.15e-02	8.14e-01
Inositol phosphate metabolism	41	3.67e-01	8.15e-02	7.32e-01
Meiotic synapsis	23	4.99e-01	-8.14e-02	8.29e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	5.99e-01	8.12e-02	8.65e-01
mRNA Splicing - Major Pathway	162	7.63e-02	-8.10e-02	3.49e-01
FOXO-mediated transcription	57	2.92e-01	8.08e-02	6.56e-01
Downstream signaling of activated FGFR1	20	5.32e-01	8.07e-02	8.39e-01
DAG and IP3 signaling	36	4.04e-01	8.04e-02	7.75e-01
MAPK6/MAPK4 signaling	73	2.36e-01	8.03e-02	6.02e-01
G1/S Transition	109	1.49e-01	8.03e-02	4.79e-01
Downstream signaling events of B Cell Receptor (BCR)	68	2.53e-01	8.02e-02	6.20e-01
mRNA Splicing	170	7.26e-02	-8.01e-02	3.41e-01
Signaling by NTRK1 (TRKA)	102	1.63e-01	8.01e-02	5.03e-01
Integrin signaling	26	4.80e-01	8.01e-02	8.14e-01
G alpha (i) signalling events	165	7.70e-02	8.00e-02	3.49e-01
Downstream signaling of activated FGFR3	17	5.69e-01	7.99e-02	8.53e-01
HDACs deacetylate histones	30	4.49e-01	7.99e-02	7.99e-01
PI-3K cascade:FGFR2	11	6.48e-01	-7.95e-02	8.92e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	3.51e-01	7.95e-02	7.16e-01
Pre-NOTCH Processing in Golgi	16	5.84e-01	7.91e-02	8.58e-01
VEGFA-VEGFR2 Pathway	88	2.01e-01	7.90e-02	5.57e-01
SHC1 events in ERBB2 signaling	16	5.84e-01	7.90e-02	8.58e-01
APC-Cdc20 mediated degradation of Nek2A	21	5.32e-01	-7.89e-02	8.39e-01
Molecules associated with elastic fibres	26	4.88e-01	7.86e-02	8.21e-01
Developmental Biology	620	9.88e-04	7.85e-02	2.58e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity	21	5.34e-01	7.84e-02	8.39e-01
Trafficking of AMPA receptors	21	5.34e-01	7.84e-02	8.39e-01
Transcriptional regulation by small RNAs	40	3.92e-01	7.83e-02	7.58e-01
Toll-like Receptor Cascades	130	1.24e-01	7.83e-02	4.38e-01
Integrin cell surface interactions	54	3.20e-01	7.83e-02	6.84e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	47	3.54e-01	7.82e-02	7.20e-01
COPII-mediated vesicle transport	56	3.13e-01	7.81e-02	6.74e-01
Fatty acid metabolism	125	1.34e-01	-7.77e-02	4.58e-01
Antiviral mechanism by IFN-stimulated genes	64	2.84e-01	7.75e-02	6.47e-01
Iron uptake and transport	45	3.69e-01	-7.75e-02	7.32e-01
ISG15 antiviral mechanism	59	3.04e-01	7.75e-02	6.66e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	6.29e-01	7.74e-02	8.88e-01
Metabolism of nitric oxide: NOS3 activation and regulation	14	6.17e-01	7.73e-02	8.78e-01
Assembly of the pre-replicative complex	58	3.10e-01	7.72e-02	6.72e-01
Signaling by EGFR in Cancer	19	5.62e-01	7.69e-02	8.50e-01
Organelle biogenesis and maintenance	228	4.70e-02	-7.67e-02	2.76e-01
Diseases of signal transduction by growth factor receptors and second messengers	319	2.04e-02	7.60e-02	1.72e-01
AMER1 mutants destabilize the destruction complex	13	6.37e-01	7.57e-02	8.88e-01
APC truncation mutants have impaired AXIN binding	13	6.37e-01	7.57e-02	8.88e-01
AXIN missense mutants destabilize the destruction complex	13	6.37e-01	7.57e-02	8.88e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	13	6.37e-01	7.57e-02	8.88e-01
Truncations of AMER1 destabilize the destruction complex	13	6.37e-01	7.57e-02	8.88e-01
truncated APC mutants destabilize the destruction complex	13	6.37e-01	7.57e-02	8.88e-01
Signaling by GPCR	345	1.65e-02	7.56e-02	1.50e-01
Activation of gene expression by SREBF (SREBP)	40	4.09e-01	7.56e-02	7.75e-01
PKMTs methylate histone lysines	37	4.28e-01	-7.54e-02	7.88e-01
DAP12 signaling	21	5.50e-01	7.54e-02	8.48e-01
Glucose metabolism	76	2.59e-01	-7.50e-02	6.23e-01
Adrenaline,noradrenaline inhibits insulin secretion	18	5.84e-01	7.46e-02	8.58e-01
Nervous system development	408	1.06e-02	7.44e-02	1.23e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	85	2.40e-01	7.38e-02	6.04e-01
Toll Like Receptor 2 (TLR2) Cascade	85	2.40e-01	7.38e-02	6.04e-01
Toll Like Receptor TLR1:TLR2 Cascade	85	2.40e-01	7.38e-02	6.04e-01
Toll Like Receptor TLR6:TLR2 Cascade	85	2.40e-01	7.38e-02	6.04e-01
FGFR2 alternative splicing	22	5.50e-01	-7.36e-02	8.48e-01
RHO GTPases Activate NADPH Oxidases	17	6.00e-01	7.35e-02	8.65e-01
Formation of Fibrin Clot (Clotting Cascade)	21	5.63e-01	7.29e-02	8.50e-01
Signaling by FGFR3 fusions in cancer	10	6.90e-01	7.28e-02	9.13e-01
Adaptive Immune System	520	5.07e-03	7.26e-02	7.34e-02
Prefoldin mediated transfer of substrate to CCT/TriC	22	5.60e-01	7.18e-02	8.49e-01
TBC/RABGAPs	40	4.34e-01	7.15e-02	7.90e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	85	2.56e-01	-7.14e-02	6.22e-01
Retinoid metabolism and transport	28	5.14e-01	7.13e-02	8.37e-01
Axon guidance	388	1.68e-02	7.13e-02	1.51e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	54	3.66e-01	7.12e-02	7.32e-01
Protein methylation	10	6.98e-01	7.10e-02	9.16e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	4.95e-01	-7.09e-02	8.25e-01
tRNA processing	99	2.26e-01	7.06e-02	5.89e-01
Synthesis of pyrophosphates in the cytosol	10	7.00e-01	-7.05e-02	9.16e-01
Signaling by TGF-beta Receptor Complex	67	3.20e-01	7.03e-02	6.84e-01
Deadenylation of mRNA	24	5.54e-01	6.99e-02	8.48e-01
Protein folding	76	2.93e-01	6.98e-02	6.56e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	40	4.45e-01	6.98e-02	7.95e-01
FRS-mediated FGFR4 signaling	13	6.64e-01	6.96e-02	8.95e-01
Cellular responses to external stimuli	413	1.62e-02	6.96e-02	1.49e-01
Incretin synthesis, secretion, and inactivation	10	7.03e-01	-6.95e-02	9.18e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	10	7.03e-01	-6.95e-02	9.18e-01
Vasopressin regulates renal water homeostasis via Aquaporins	30	5.11e-01	6.94e-02	8.35e-01
Aquaporin-mediated transport	32	4.98e-01	6.93e-02	8.28e-01
Sphingolipid de novo biosynthesis	33	4.91e-01	6.93e-02	8.23e-01
HATs acetylate histones	72	3.12e-01	-6.90e-02	6.74e-01
SUMOylation of transcription factors	14	6.56e-01	6.88e-02	8.93e-01
Regulation of TNFR1 signaling	26	5.45e-01	6.87e-02	8.44e-01
Platelet activation, signaling and aggregation	209	8.87e-02	6.86e-02	3.78e-01
Constitutive Signaling by EGFRvIII	15	6.46e-01	6.84e-02	8.92e-01
Signaling by EGFRvIII in Cancer	15	6.46e-01	6.84e-02	8.92e-01
Cholesterol biosynthesis	22	5.80e-01	-6.82e-02	8.58e-01
Signaling by FGFR1 in disease	32	5.06e-01	-6.80e-02	8.34e-01
Disease	1045	2.90e-04	6.78e-02	1.06e-02
Platelet homeostasis	64	3.50e-01	6.77e-02	7.15e-01
Degradation of GLI1 by the proteasome	51	4.04e-01	-6.76e-02	7.75e-01
G alpha (z) signalling events	33	5.03e-01	6.75e-02	8.32e-01
SCF(Skp2)-mediated degradation of p27/p21	50	4.10e-01	6.74e-02	7.75e-01
Diseases associated with N-glycosylation of proteins	16	6.41e-01	6.73e-02	8.88e-01
tRNA modification in the nucleus and cytosol	37	4.80e-01	6.71e-02	8.14e-01
Metabolism of amino acids and derivatives	234	7.84e-02	-6.71e-02	3.50e-01
Downstream signal transduction	28	5.40e-01	6.69e-02	8.41e-01
Golgi Associated Vesicle Biogenesis	50	4.17e-01	6.64e-02	7.75e-01
Signal Transduction	1561	2.87e-05	6.57e-02	1.92e-03
Sphingolipid metabolism	67	3.56e-01	6.53e-02	7.22e-01
Regulation of PTEN mRNA translation	11	7.08e-01	-6.53e-02	9.20e-01
Signaling by FGFR in disease	49	4.31e-01	-6.51e-02	7.89e-01
Cargo concentration in the ER	20	6.16e-01	6.48e-02	8.78e-01
Mitophagy	24	5.83e-01	-6.48e-02	8.58e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	71	3.48e-01	6.45e-02	7.14e-01
Nonsense-Mediated Decay (NMD)	71	3.48e-01	6.45e-02	7.14e-01
MECP2 regulates neuronal receptors and channels	11	7.11e-01	-6.44e-02	9.20e-01
Signaling by FGFR2	54	4.14e-01	-6.44e-02	7.75e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	17	6.47e-01	6.42e-02	8.92e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	67	3.64e-01	6.42e-02	7.32e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	7.13e-01	-6.40e-02	9.20e-01
MyD88-independent TLR4 cascade	88	3.00e-01	6.40e-02	6.61e-01
TRIF(TICAM1)-mediated TLR4 signaling	88	3.00e-01	6.40e-02	6.61e-01
Transferrin endocytosis and recycling	22	6.04e-01	-6.39e-02	8.67e-01
LDL clearance	16	6.58e-01	6.39e-02	8.93e-01
Intraflagellar transport	36	5.09e-01	-6.37e-02	8.34e-01
Infectious disease	526	1.36e-02	6.36e-02	1.42e-01
Cellular responses to stress	408	2.90e-02	6.35e-02	2.14e-01
Triglyceride metabolism	24	5.91e-01	-6.34e-02	8.62e-01
TNFR2 non-canonical NF-kB pathway	67	3.71e-01	6.33e-02	7.33e-01
Effects of PIP2 hydrolysis	18	6.42e-01	-6.33e-02	8.88e-01
Purine salvage	12	7.05e-01	6.32e-02	9.19e-01
Formation of the beta-catenin:TCF transactivating complex	28	5.64e-01	-6.30e-02	8.50e-01
DNA strand elongation	30	5.53e-01	-6.26e-02	8.48e-01
L13a-mediated translational silencing of Ceruloplasmin expression	65	3.86e-01	6.23e-02	7.49e-01
Mitotic G1 phase and G1/S transition	125	2.33e-01	6.20e-02	6.00e-01
Interleukin-6 family signaling	17	6.59e-01	6.19e-02	8.93e-01
Plasma lipoprotein assembly, remodeling, and clearance	53	4.37e-01	-6.18e-02	7.90e-01
ABC transporters in lipid homeostasis	14	6.89e-01	-6.18e-02	9.13e-01
Regulated proteolysis of p75NTR	11	7.23e-01	6.17e-02	9.26e-01
Cytosolic sensors of pathogen-associated DNA	54	4.34e-01	6.17e-02	7.90e-01
Early Phase of HIV Life Cycle	11	7.24e-01	6.15e-02	9.26e-01
Transcriptional Regulation by VENTX	35	5.31e-01	6.12e-02	8.39e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	27	5.82e-01	6.12e-02	8.58e-01
GPCR downstream signalling	317	6.28e-02	6.12e-02	3.25e-01
Glycosphingolipid metabolism	34	5.37e-01	6.12e-02	8.39e-01
Metabolism of water-soluble vitamins and cofactors	96	3.02e-01	6.10e-02	6.64e-01
TNFR1-induced proapoptotic signaling	12	7.15e-01	-6.09e-02	9.20e-01
Intrinsic Pathway for Apoptosis	43	4.90e-01	6.09e-02	8.23e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	20	6.39e-01	6.07e-02	8.88e-01
MAPK family signaling cascades	245	1.05e-01	6.05e-02	4.08e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	17	6.67e-01	6.03e-02	8.95e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	17	6.67e-01	6.03e-02	8.95e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	7.29e-01	-6.03e-02	9.27e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	5.55e-01	-6.03e-02	8.48e-01
Toll Like Receptor 3 (TLR3) Cascade	86	3.36e-01	6.01e-02	7.06e-01
SHC-mediated cascade:FGFR1	11	7.31e-01	5.98e-02	9.27e-01
Ribosomal scanning and start codon recognition	41	5.08e-01	5.97e-02	8.34e-01
SARS-CoV-1 Infection	43	5.00e-01	5.96e-02	8.29e-01
CLEC7A (Dectin-1) induces NFAT activation	10	7.46e-01	5.91e-02	9.27e-01
CRMPs in Sema3A signaling	13	7.13e-01	5.88e-02	9.20e-01
Deubiquitination	213	1.41e-01	5.88e-02	4.66e-01
Regulation of FZD by ubiquitination	11	7.37e-01	5.85e-02	9.27e-01
Transcriptional Regulation by TP53	305	8.13e-02	-5.84e-02	3.61e-01
ERK/MAPK targets	22	6.37e-01	-5.82e-02	8.88e-01
GLI3 is processed to GLI3R by the proteasome	50	4.80e-01	-5.79e-02	8.14e-01
Macroautophagy	102	3.14e-01	-5.78e-02	6.76e-01
Deadenylation-dependent mRNA decay	52	4.72e-01	5.77e-02	8.14e-01
Degradation of GLI2 by the proteasome	50	4.81e-01	-5.77e-02	8.14e-01
Apoptotic factor-mediated response	13	7.19e-01	5.77e-02	9.23e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	80	3.74e-01	5.76e-02	7.37e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	6.73e-01	5.76e-02	8.99e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	41	5.25e-01	5.74e-02	8.39e-01
Carnitine metabolism	12	7.31e-01	5.74e-02	9.27e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	7.53e-01	5.74e-02	9.27e-01
Signaling by Nuclear Receptors	188	1.77e-01	5.73e-02	5.18e-01
NCAM1 interactions	25	6.21e-01	5.71e-02	8.81e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	12	7.34e-01	5.67e-02	9.27e-01
Signaling by high-kinase activity BRAF mutants	33	5.74e-01	5.66e-02	8.57e-01
RHO GTPase Effectors	187	1.83e-01	5.66e-02	5.30e-01
Hedgehog ligand biogenesis	51	4.86e-01	5.64e-02	8.20e-01
Class I MHC mediated antigen processing & presentation	313	8.91e-02	5.62e-02	3.78e-01
Plasma lipoprotein remodeling	21	6.56e-01	-5.62e-02	8.93e-01
RAF-independent MAPK1/3 activation	20	6.66e-01	5.57e-02	8.95e-01
Resolution of Sister Chromatid Cohesion	68	4.31e-01	-5.52e-02	7.89e-01
Signaling by ERBB4	39	5.52e-01	5.51e-02	8.48e-01
activated TAK1 mediates p38 MAPK activation	18	6.87e-01	5.48e-02	9.11e-01
Signaling by NOTCH1	64	4.49e-01	5.47e-02	7.99e-01
Ub-specific processing proteases	145	2.58e-01	5.46e-02	6.23e-01
Purine catabolism	16	7.07e-01	-5.44e-02	9.20e-01
PI3K events in ERBB2 signaling	10	7.68e-01	5.40e-02	9.37e-01
Metabolism of fat-soluble vitamins	31	6.05e-01	5.37e-02	8.68e-01
Processing of Capped Intron-Containing Pre-mRNA	214	1.78e-01	-5.37e-02	5.18e-01
Uptake and function of anthrax toxins	11	7.58e-01	5.36e-02	9.30e-01
Synthesis of PIPs at the late endosome membrane	10	7.70e-01	-5.34e-02	9.37e-01
MyD88 cascade initiated on plasma membrane	77	4.19e-01	5.33e-02	7.76e-01
Toll Like Receptor 10 (TLR10) Cascade	77	4.19e-01	5.33e-02	7.76e-01
Toll Like Receptor 5 (TLR5) Cascade	77	4.19e-01	5.33e-02	7.76e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	19	6.88e-01	-5.33e-02	9.11e-01
Positive epigenetic regulation of rRNA expression	44	5.41e-01	5.33e-02	8.41e-01
Regulation of APC/C activators between G1/S and early anaphase	65	4.62e-01	-5.28e-02	8.07e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	7.24e-01	-5.27e-02	9.26e-01
Signaling by NOTCH	154	2.64e-01	5.23e-02	6.27e-01
MyD88 dependent cascade initiated on endosome	81	4.17e-01	5.23e-02	7.75e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	81	4.17e-01	5.23e-02	7.75e-01
Neurexins and neuroligins	27	6.41e-01	5.18e-02	8.88e-01
Peptide hormone metabolism	48	5.38e-01	-5.15e-02	8.39e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	51	5.27e-01	5.13e-02	8.39e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	51	5.27e-01	5.13e-02	8.39e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	51	5.27e-01	5.13e-02	8.39e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	51	5.27e-01	5.13e-02	8.39e-01
Signaling by NOTCH1 in Cancer	51	5.27e-01	5.13e-02	8.39e-01
Synthesis of DNA	104	3.68e-01	-5.12e-02	7.32e-01
Translation initiation complex formation	40	5.84e-01	5.00e-02	8.58e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	7.10e-01	4.93e-02	9.20e-01
Mitotic Spindle Checkpoint	77	4.56e-01	-4.92e-02	8.02e-01
Deactivation of the beta-catenin transactivating complex	34	6.20e-01	-4.91e-02	8.81e-01
Signaling by FGFR1	35	6.17e-01	4.89e-02	8.78e-01
G1/S DNA Damage Checkpoints	55	5.32e-01	4.88e-02	8.39e-01
Class B/2 (Secretin family receptors)	42	5.85e-01	-4.87e-02	8.58e-01
G beta:gamma signalling through BTK	11	7.80e-01	4.87e-02	9.43e-01
Kinesins	21	7.00e-01	4.86e-02	9.16e-01
RHO GTPases activate PKNs	32	6.34e-01	-4.86e-02	8.88e-01
Misspliced GSK3beta mutants stabilize beta-catenin	14	7.54e-01	4.84e-02	9.27e-01
S33 mutants of beta-catenin aren't phosphorylated	14	7.54e-01	4.84e-02	9.27e-01
S37 mutants of beta-catenin aren't phosphorylated	14	7.54e-01	4.84e-02	9.27e-01
S45 mutants of beta-catenin aren't phosphorylated	14	7.54e-01	4.84e-02	9.27e-01
T41 mutants of beta-catenin aren't phosphorylated	14	7.54e-01	4.84e-02	9.27e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	14	7.54e-01	4.84e-02	9.27e-01
Ubiquitin-dependent degradation of Cyclin D	44	5.80e-01	4.82e-02	8.58e-01
Signaling by BRAF and RAF fusions	57	5.29e-01	4.82e-02	8.39e-01
RAB geranylgeranylation	42	5.95e-01	-4.75e-02	8.65e-01
Formation of a pool of free 40S subunits	57	5.36e-01	4.74e-02	8.39e-01
Rho GTPase cycle	116	3.80e-01	4.73e-02	7.41e-01
RNA Polymerase I Promoter Clearance	47	5.76e-01	-4.72e-02	8.58e-01
tRNA processing in the nucleus	50	5.67e-01	4.68e-02	8.52e-01
PI-3K cascade:FGFR1	11	7.89e-01	-4.66e-02	9.49e-01
Regulation of ornithine decarboxylase (ODC)	44	5.95e-01	4.64e-02	8.65e-01
RNA Polymerase II Transcription Termination	59	5.39e-01	-4.63e-02	8.40e-01
PPARA activates gene expression	105	4.15e-01	4.62e-02	7.75e-01
Arachidonic acid metabolism	34	6.42e-01	-4.61e-02	8.88e-01
Cellular response to hypoxia	62	5.31e-01	4.60e-02	8.39e-01
Platelet degranulation	107	4.12e-01	4.60e-02	7.75e-01
MTOR signalling	39	6.19e-01	-4.60e-02	8.81e-01
Response to elevated platelet cytosolic Ca2+	111	4.05e-01	4.59e-02	7.75e-01
Sema4D in semaphorin signaling	24	6.98e-01	4.59e-02	9.16e-01
cGMP effects	10	8.03e-01	4.55e-02	9.50e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	27	6.83e-01	-4.54e-02	9.10e-01
Signaling by Rho GTPases	294	1.84e-01	4.53e-02	5.30e-01
Activation of kainate receptors upon glutamate binding	19	7.34e-01	4.51e-02	9.27e-01
Toll Like Receptor 9 (TLR9) Cascade	84	4.78e-01	4.49e-02	8.14e-01
Hh mutants abrogate ligand secretion	48	5.91e-01	4.48e-02	8.62e-01
ER Quality Control Compartment (ERQC)	18	7.42e-01	4.48e-02	9.27e-01
Opioid Signalling	69	5.23e-01	4.45e-02	8.39e-01
Orc1 removal from chromatin	59	5.56e-01	4.43e-02	8.49e-01
SUMOylation of chromatin organization proteins	47	6.01e-01	4.42e-02	8.65e-01
DNA Replication	108	4.29e-01	-4.41e-02	7.89e-01
RAS processing	19	7.40e-01	-4.40e-02	9.27e-01
Heme degradation	11	8.00e-01	4.40e-02	9.49e-01
MAPK1/MAPK3 signaling	213	2.71e-01	4.39e-02	6.34e-01
p53-Dependent G1 DNA Damage Response	54	5.81e-01	4.34e-02	8.58e-01
p53-Dependent G1/S DNA damage checkpoint	54	5.81e-01	4.34e-02	8.58e-01
FLT3 Signaling	222	2.68e-01	4.34e-02	6.32e-01
Signaling by NTRK3 (TRKC)	16	7.65e-01	-4.32e-02	9.35e-01
Cell-cell junction organization	24	7.15e-01	-4.31e-02	9.20e-01
Regulation of lipid metabolism by PPARalpha	107	4.44e-01	4.30e-02	7.94e-01
UCH proteinases	75	5.22e-01	4.28e-02	8.39e-01
Adherens junctions interactions	12	7.98e-01	4.27e-02	9.49e-01
Metabolism of carbohydrates	222	2.75e-01	4.27e-02	6.40e-01
Signaling by FGFR4 in disease	11	8.07e-01	4.25e-02	9.51e-01
Cap-dependent Translation Initiation	73	5.31e-01	4.24e-02	8.39e-01
Eukaryotic Translation Initiation	73	5.31e-01	4.24e-02	8.39e-01
Separation of Sister Chromatids	127	4.11e-01	-4.23e-02	7.75e-01
NOD1/2 Signaling Pathway	29	6.94e-01	4.22e-02	9.16e-01
Nuclear signaling by ERBB4	22	7.33e-01	4.20e-02	9.27e-01
Metabolism of steroids	97	4.77e-01	4.19e-02	8.14e-01
PCP/CE pathway	80	5.25e-01	4.12e-02	8.39e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR)	34	6.81e-01	4.08e-02	9.08e-01
G alpha (12/13) signalling events	60	5.87e-01	4.06e-02	8.60e-01
Ion channel transport	97	4.92e-01	-4.05e-02	8.23e-01
Caspase activation via extrinsic apoptotic signalling pathway	22	7.43e-01	4.03e-02	9.27e-01
N-Glycan antennae elongation	12	8.09e-01	4.02e-02	9.51e-01
Amino acids regulate mTORC1	48	6.31e-01	4.01e-02	8.88e-01
Programmed Cell Death	141	4.12e-01	4.01e-02	7.75e-01
Signaling by ROBO receptors	147	4.05e-01	3.99e-02	7.75e-01
NOTCH1 Intracellular Domain Regulates Transcription	42	6.55e-01	3.99e-02	8.93e-01
Common Pathway of Fibrin Clot Formation	13	8.05e-01	-3.96e-02	9.50e-01
rRNA modification in the nucleus and cytosol	52	6.22e-01	3.96e-02	8.82e-01
DNA Damage Recognition in GG-NER	35	6.86e-01	-3.95e-02	9.11e-01
TCR signaling	87	5.27e-01	3.93e-02	8.39e-01
Regulation of PTEN stability and activity	60	6.00e-01	3.92e-02	8.65e-01
Death Receptor Signalling	117	4.66e-01	3.91e-02	8.12e-01
RNA Polymerase I Transcription Initiation	44	6.58e-01	-3.86e-02	8.93e-01
Metabolism of porphyrins	23	7.50e-01	3.85e-02	9.27e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	7.98e-01	3.82e-02	9.49e-01
Epigenetic regulation of gene expression	83	5.50e-01	-3.80e-02	8.48e-01
Viral Messenger RNA Synthesis	36	6.95e-01	3.78e-02	9.16e-01
CD209 (DC-SIGN) signaling	18	7.82e-01	3.77e-02	9.44e-01
Signaling by WNT in cancer	28	7.30e-01	3.77e-02	9.27e-01
RNA Polymerase I Transcription	48	6.52e-01	-3.76e-02	8.93e-01
NR1H2 and NR1H3-mediated signaling	39	6.85e-01	-3.76e-02	9.11e-01
Repression of WNT target genes	11	8.29e-01	3.75e-02	9.56e-01
Activation of the pre-replicative complex	26	7.42e-01	3.73e-02	9.27e-01
Glycolysis	58	6.24e-01	-3.72e-02	8.84e-01
Clathrin-mediated endocytosis	112	4.98e-01	3.72e-02	8.28e-01
Beta-catenin phosphorylation cascade	15	8.04e-01	3.70e-02	9.50e-01
RAF/MAP kinase cascade	209	3.60e-01	3.69e-02	7.27e-01
SCF-beta-TrCP mediated degradation of Emi1	45	6.70e-01	-3.68e-02	8.98e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	46	6.67e-01	-3.68e-02	8.95e-01
Receptor Mediated Mitophagy	11	8.33e-01	-3.67e-02	9.56e-01
TGF-beta receptor signaling activates SMADs	29	7.33e-01	3.66e-02	9.27e-01
Ca2+ pathway	48	6.62e-01	-3.65e-02	8.95e-01
Listeria monocytogenes entry into host cells	15	8.08e-01	3.62e-02	9.51e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	17	7.97e-01	-3.61e-02	9.49e-01
DNA Double Strand Break Response	36	7.12e-01	-3.56e-02	9.20e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	36	7.12e-01	-3.56e-02	9.20e-01
Cellular Senescence	116	5.13e-01	3.52e-02	8.37e-01
Selective autophagy	52	6.61e-01	-3.52e-02	8.95e-01
Nucleobase catabolism	26	7.58e-01	3.49e-02	9.30e-01
Synthesis of PIPs at the plasma membrane	49	6.73e-01	3.49e-02	8.99e-01
Synaptic adhesion-like molecules	12	8.35e-01	3.47e-02	9.56e-01
FCERI mediated Ca+2 mobilization	22	7.79e-01	3.46e-02	9.42e-01
Asymmetric localization of PCP proteins	55	6.58e-01	3.46e-02	8.93e-01
ADP signalling through P2Y purinoceptor 1	18	8.00e-01	3.45e-02	9.49e-01
Integration of energy metabolism	80	5.96e-01	3.44e-02	8.65e-01
Condensation of Prophase Chromosomes	10	8.51e-01	3.42e-02	9.58e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	8.34e-01	3.35e-02	9.56e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	68	6.34e-01	-3.34e-02	8.88e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	60	6.55e-01	-3.34e-02	8.93e-01
Amplification of signal from the kinetochores	60	6.55e-01	-3.34e-02	8.93e-01
C-type lectin receptors (CLRs)	103	5.61e-01	3.32e-02	8.49e-01
Cytochrome c-mediated apoptotic response	10	8.56e-01	-3.32e-02	9.58e-01
HCMV Infection	72	6.30e-01	-3.29e-02	8.88e-01
Transport to the Golgi and subsequent modification	138	5.07e-01	3.28e-02	8.34e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	35	7.38e-01	3.27e-02	9.27e-01
Diseases of mitotic cell cycle	35	7.38e-01	3.27e-02	9.27e-01
HIV Infection	195	4.34e-01	-3.26e-02	7.90e-01
E2F mediated regulation of DNA replication	18	8.11e-01	-3.26e-02	9.51e-01
NRIF signals cell death from the nucleus	14	8.37e-01	3.18e-02	9.56e-01
Activation of HOX genes during differentiation	50	6.99e-01	-3.16e-02	9.16e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	50	6.99e-01	-3.16e-02	9.16e-01
Metabolism	1514	4.78e-02	-3.15e-02	2.76e-01
Metabolism of folate and pterines	14	8.41e-01	3.10e-02	9.56e-01
RHO GTPases activate CIT	18	8.21e-01	-3.08e-02	9.54e-01
Negative regulation of FGFR3 signaling	19	8.17e-01	3.07e-02	9.53e-01
Signaling by PDGFRA extracellular domain mutants	12	8.54e-01	-3.06e-02	9.58e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.54e-01	-3.06e-02	9.58e-01
G beta:gamma signalling through PLC beta	13	8.49e-01	-3.06e-02	9.58e-01
Presynaptic function of Kainate receptors	13	8.49e-01	-3.06e-02	9.58e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	29	7.77e-01	3.04e-02	9.42e-01
Autophagy	113	5.79e-01	-3.03e-02	8.58e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	25	7.95e-01	-3.01e-02	9.49e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	8.69e-01	3.00e-02	9.65e-01
SUMOylation of intracellular receptors	23	8.04e-01	2.99e-02	9.50e-01
Degradation of beta-catenin by the destruction complex	72	6.64e-01	-2.96e-02	8.95e-01
TP53 Regulates Metabolic Genes	78	6.52e-01	2.96e-02	8.93e-01
Spry regulation of FGF signaling	14	8.50e-01	-2.91e-02	9.58e-01
COPI-mediated anterograde transport	74	6.66e-01	-2.91e-02	8.95e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	7.44e-01	2.91e-02	9.27e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	147	5.45e-01	2.90e-02	8.44e-01
Downstream signaling of activated FGFR2	18	8.32e-01	2.89e-02	9.56e-01
Glucagon-type ligand receptors	16	8.43e-01	-2.87e-02	9.56e-01
Oncogenic MAPK signaling	73	6.73e-01	2.86e-02	8.99e-01
Metabolism of vitamins and cofactors	144	5.55e-01	2.86e-02	8.48e-01
Cyclin D associated events in G1	41	7.53e-01	-2.84e-02	9.27e-01
G1 Phase	41	7.53e-01	-2.84e-02	9.27e-01
Degradation of DVL	48	7.34e-01	-2.84e-02	9.27e-01
SUMOylation	140	5.66e-01	-2.82e-02	8.51e-01
Diseases of metabolism	168	5.36e-01	2.78e-02	8.39e-01
Negative regulation of FGFR4 signaling	20	8.31e-01	-2.76e-02	9.56e-01
IRS-mediated signalling	30	7.94e-01	2.76e-02	9.49e-01
Oncogene Induced Senescence	30	7.94e-01	2.75e-02	9.49e-01
Apoptosis	138	5.84e-01	2.71e-02	8.58e-01
APC/C:Cdc20 mediated degradation of Securin	59	7.20e-01	-2.70e-02	9.24e-01
SHC-mediated cascade:FGFR2	11	8.77e-01	2.69e-02	9.69e-01
Apoptotic execution phase	35	7.84e-01	2.68e-02	9.45e-01
Rap1 signalling	14	8.63e-01	-2.67e-02	9.62e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	46	7.54e-01	2.67e-02	9.27e-01
PIWI-interacting RNA (piRNA) biogenesis	13	8.68e-01	2.65e-02	9.65e-01
Regulation of PLK1 Activity at G2/M Transition	74	6.94e-01	-2.65e-02	9.16e-01
Cyclin A/B1/B2 associated events during G2/M transition	16	8.55e-01	-2.65e-02	9.58e-01
Cell Cycle, Mitotic	399	3.68e-01	2.65e-02	7.32e-01
Formation of the ternary complex, and subsequently, the 43S complex	34	7.91e-01	2.63e-02	9.49e-01
Triglyceride catabolism	16	8.56e-01	-2.62e-02	9.58e-01
RNA polymerase II transcribes snRNA genes	68	7.10e-01	-2.61e-02	9.20e-01
TCF dependent signaling in response to WNT	137	6.00e-01	2.60e-02	8.65e-01
RNA Polymerase III Abortive And Retractive Initiation	39	7.79e-01	-2.60e-02	9.42e-01
RNA Polymerase III Transcription	39	7.79e-01	-2.60e-02	9.42e-01
PI3K Cascade	26	8.19e-01	2.60e-02	9.53e-01
Post-translational protein phosphorylation	77	6.95e-01	-2.59e-02	9.16e-01
RNA Polymerase I Transcription Termination	29	8.13e-01	-2.54e-02	9.51e-01
Regulation of RAS by GAPs	57	7.43e-01	2.52e-02	9.27e-01
Glycerophospholipid biosynthesis	87	6.86e-01	2.52e-02	9.11e-01
Autodegradation of the E3 ubiquitin ligase COP1	44	7.73e-01	2.51e-02	9.39e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	63	7.31e-01	-2.51e-02	9.27e-01
Stabilization of p53	48	7.65e-01	2.50e-02	9.35e-01
Assembly Of The HIV Virion	12	8.81e-01	2.49e-02	9.69e-01
Regulation of expression of SLITs and ROBOs	108	6.57e-01	2.48e-02	8.93e-01
Nuclear Receptor transcription pathway	37	7.94e-01	2.48e-02	9.49e-01
Heme biosynthesis	14	8.72e-01	-2.48e-02	9.67e-01
Circadian Clock	62	7.40e-01	-2.44e-02	9.27e-01
Late endosomal microautophagy	25	8.33e-01	-2.44e-02	9.56e-01
Sema4D induced cell migration and growth-cone collapse	20	8.51e-01	2.43e-02	9.58e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	61	7.45e-01	-2.41e-02	9.27e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	61	7.45e-01	-2.41e-02	9.27e-01
Role of phospholipids in phagocytosis	21	8.49e-01	-2.40e-02	9.58e-01
SUMOylation of DNA damage response and repair proteins	64	7.41e-01	-2.39e-02	9.27e-01
Transport of vitamins, nucleosides, and related molecules	28	8.27e-01	-2.38e-02	9.56e-01
Insulin receptor recycling	18	8.62e-01	-2.36e-02	9.62e-01
HCMV Early Events	52	7.73e-01	2.32e-02	9.39e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	54	7.69e-01	2.31e-02	9.37e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	11	8.95e-01	2.30e-02	9.70e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	11	8.95e-01	2.30e-02	9.70e-01
Visual phototransduction	48	7.83e-01	-2.30e-02	9.45e-01
CLEC7A (Dectin-1) signaling	85	7.15e-01	2.29e-02	9.20e-01
DNA Replication Pre-Initiation	70	7.41e-01	2.28e-02	9.27e-01
Signaling by FGFR4	30	8.29e-01	-2.28e-02	9.56e-01
mTORC1-mediated signalling	22	8.54e-01	-2.26e-02	9.58e-01
Insulin receptor signalling cascade	35	8.19e-01	-2.24e-02	9.53e-01
Membrane binding and targetting of GAG proteins	10	9.03e-01	-2.22e-02	9.70e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	10	9.03e-01	-2.22e-02	9.70e-01
Thrombin signalling through proteinase activated receptors (PARs)	24	8.51e-01	-2.22e-02	9.58e-01
Signaling by FGFR3 in disease	14	8.88e-01	2.17e-02	9.70e-01
Signaling by FGFR3 point mutants in cancer	14	8.88e-01	2.17e-02	9.70e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	9.02e-01	2.15e-02	9.70e-01
CDT1 association with the CDC6:ORC:origin complex	49	7.97e-01	2.13e-02	9.49e-01
Activation of SMO	13	8.94e-01	2.13e-02	9.70e-01
Signaling by the B Cell Receptor (BCR)	91	7.27e-01	2.12e-02	9.27e-01
Infection with Mycobacterium tuberculosis	23	8.61e-01	-2.12e-02	9.61e-01
Negative regulation of NOTCH4 signaling	48	8.01e-01	-2.11e-02	9.49e-01
Vpu mediated degradation of CD4	43	8.12e-01	-2.10e-02	9.51e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	9.00e-01	-2.10e-02	9.70e-01
Cilium Assembly	161	6.50e-01	-2.08e-02	8.93e-01
Stimuli-sensing channels	44	8.12e-01	-2.08e-02	9.51e-01
Inwardly rectifying K+ channels	18	8.79e-01	2.07e-02	9.69e-01
Signaling by Hedgehog	115	7.03e-01	2.06e-02	9.18e-01
Tie2 Signaling	16	8.89e-01	2.01e-02	9.70e-01
Defective CFTR causes cystic fibrosis	50	8.07e-01	2.00e-02	9.51e-01
Interleukin-17 signaling	62	7.87e-01	1.99e-02	9.48e-01
Vif-mediated degradation of APOBEC3G	43	8.23e-01	-1.98e-02	9.54e-01
G alpha (q) signalling events	97	7.39e-01	1.96e-02	9.27e-01
Sialic acid metabolism	25	8.65e-01	1.96e-02	9.64e-01
Role of LAT2/NTAL/LAB on calcium mobilization	12	9.08e-01	-1.93e-02	9.74e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	60	7.98e-01	-1.91e-02	9.49e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	7.98e-01	-1.91e-02	9.49e-01
Cell Cycle Checkpoints	193	6.52e-01	-1.89e-02	8.93e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	23	8.76e-01	1.88e-02	9.69e-01
MicroRNA (miRNA) biogenesis	22	8.83e-01	1.82e-02	9.69e-01
Vesicle-mediated transport	528	4.92e-01	1.77e-02	8.23e-01
Negative epigenetic regulation of rRNA expression	47	8.38e-01	-1.73e-02	9.56e-01
Metabolism of non-coding RNA	45	8.42e-01	-1.71e-02	9.56e-01
snRNP Assembly	45	8.42e-01	-1.71e-02	9.56e-01
ER to Golgi Anterograde Transport	115	7.54e-01	-1.70e-02	9.27e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	31	8.72e-01	-1.68e-02	9.66e-01
Beta-catenin independent WNT signaling	121	7.53e-01	1.66e-02	9.27e-01
CDK-mediated phosphorylation and removal of Cdc6	61	8.24e-01	-1.65e-02	9.55e-01
Unblocking of NMDA receptors, glutamate binding and activation	10	9.28e-01	-1.64e-02	9.77e-01
Fc epsilon receptor (FCERI) signaling	111	7.68e-01	1.62e-02	9.37e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	8.43e-01	-1.60e-02	9.56e-01
Golgi-to-ER retrograde transport	86	7.99e-01	1.59e-02	9.49e-01
Centrosome maturation	72	8.17e-01	-1.58e-02	9.53e-01
Recruitment of mitotic centrosome proteins and complexes	72	8.17e-01	-1.58e-02	9.53e-01
Switching of origins to a post-replicative state	78	8.13e-01	1.55e-02	9.51e-01
Signaling by FGFR3	29	8.85e-01	1.55e-02	9.69e-01
DNA Damage/Telomere Stress Induced Senescence	24	8.96e-01	1.54e-02	9.70e-01
Apoptotic cleavage of cellular proteins	28	8.90e-01	1.51e-02	9.70e-01
ABC transporter disorders	60	8.40e-01	1.50e-02	9.56e-01
AURKA Activation by TPX2	62	8.39e-01	1.50e-02	9.56e-01
Transport of Mature Transcript to Cytoplasm	72	8.27e-01	1.49e-02	9.56e-01
M Phase	278	6.73e-01	1.48e-02	8.99e-01
APC/C-mediated degradation of cell cycle proteins	70	8.34e-01	-1.45e-02	9.56e-01
Regulation of mitotic cell cycle	70	8.34e-01	-1.45e-02	9.56e-01
RAF activation	34	8.84e-01	-1.45e-02	9.69e-01
Dectin-1 mediated noncanonical NF-kB signaling	51	8.58e-01	1.45e-02	9.59e-01
Cargo trafficking to the periciliary membrane	44	8.69e-01	1.43e-02	9.65e-01
Keratan sulfate degradation	11	9.35e-01	1.43e-02	9.80e-01
Activation of G protein gated Potassium channels	14	9.26e-01	1.43e-02	9.76e-01
G protein gated Potassium channels	14	9.26e-01	1.43e-02	9.76e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	14	9.26e-01	1.43e-02	9.76e-01
p130Cas linkage to MAPK signaling for integrins	15	9.25e-01	1.40e-02	9.76e-01
Mitotic G2-G2/M phases	156	7.63e-01	1.40e-02	9.35e-01
Anchoring of the basal body to the plasma membrane	83	8.26e-01	-1.40e-02	9.56e-01
FCERI mediated MAPK activation	27	9.02e-01	1.37e-02	9.70e-01
Thromboxane signalling through TP receptor	17	9.22e-01	1.37e-02	9.76e-01
Deposition of new CENPA-containing nucleosomes at the centromere	17	9.22e-01	1.37e-02	9.76e-01
Nucleosome assembly	17	9.22e-01	1.37e-02	9.76e-01
Regulation of RUNX2 expression and activity	61	8.54e-01	1.36e-02	9.58e-01
Oxidative Stress Induced Senescence	60	8.57e-01	-1.35e-02	9.58e-01
RNA Polymerase III Transcription Initiation	34	8.93e-01	-1.34e-02	9.70e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	42	8.85e-01	-1.29e-02	9.69e-01
Signaling by RAS mutants	42	8.85e-01	-1.29e-02	9.69e-01
Signaling by moderate kinase activity BRAF mutants	42	8.85e-01	-1.29e-02	9.69e-01
Signaling downstream of RAS mutants	42	8.85e-01	-1.29e-02	9.69e-01
Negative regulation of FGFR2 signaling	20	9.21e-01	-1.28e-02	9.76e-01
SUMO E3 ligases SUMOylate target proteins	134	8.00e-01	-1.27e-02	9.49e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	9.23e-01	-1.25e-02	9.76e-01
Downstream signaling of activated FGFR4	18	9.27e-01	1.24e-02	9.76e-01
HCMV Late Events	46	8.88e-01	-1.20e-02	9.70e-01
IRS-related events triggered by IGF1R	33	9.07e-01	-1.18e-02	9.74e-01
TNF signaling	36	9.03e-01	1.17e-02	9.70e-01
Retrograde transport at the Trans-Golgi-Network	43	8.99e-01	-1.11e-02	9.70e-01
S Phase	142	8.21e-01	1.10e-02	9.54e-01
Phospholipid metabolism	162	8.22e-01	1.03e-02	9.54e-01
Autodegradation of Cdh1 by Cdh1:APC/C	58	8.95e-01	-1.00e-02	9.70e-01
Mitotic Prometaphase	141	8.38e-01	-9.99e-03	9.56e-01
Neddylation	201	8.08e-01	-9.99e-03	9.51e-01
Downstream TCR signaling	72	8.84e-01	9.93e-03	9.69e-01
WNT5A-dependent internalization of FZD4	14	9.49e-01	9.89e-03	9.84e-01
Membrane Trafficking	496	7.11e-01	9.83e-03	9.20e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	26	9.31e-01	-9.75e-03	9.79e-01
NoRC negatively regulates rRNA expression	44	9.12e-01	-9.69e-03	9.76e-01
Transport of small molecules	454	7.26e-01	9.69e-03	9.27e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	59	9.03e-01	9.15e-03	9.70e-01
Mitotic Anaphase	173	8.37e-01	9.08e-03	9.56e-01
Mitotic Metaphase and Anaphase	173	8.37e-01	9.08e-03	9.56e-01
Metabolism of RNA	571	7.14e-01	9.06e-03	9.20e-01
MHC class II antigen presentation	73	8.94e-01	9.01e-03	9.70e-01
Metabolism of proteins	1454	5.78e-01	-9.00e-03	8.58e-01
Post-translational protein modification	1035	6.34e-01	8.95e-03	8.88e-01
FCERI mediated NF-kB activation	67	9.01e-01	8.79e-03	9.70e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	43	9.21e-01	8.79e-03	9.76e-01
p53-Independent DNA Damage Response	43	9.21e-01	8.79e-03	9.76e-01
p53-Independent G1/S DNA damage checkpoint	43	9.21e-01	8.79e-03	9.76e-01
TNFR1-induced NFkappaB signaling pathway	23	9.42e-01	8.69e-03	9.82e-01
Negative regulation of MAPK pathway	39	9.25e-01	-8.68e-03	9.76e-01
Regulation of Apoptosis	45	9.21e-01	-8.60e-03	9.76e-01
G2/M Checkpoints	107	8.79e-01	-8.55e-03	9.69e-01
Assembly and cell surface presentation of NMDA receptors	13	9.58e-01	8.45e-03	9.87e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	28	9.39e-01	8.38e-03	9.82e-01
Gene expression (Transcription)	1022	6.58e-01	8.36e-03	8.93e-01
Platelet Aggregation (Plug Formation)	31	9.40e-01	7.87e-03	9.82e-01
Association of TriC/CCT with target proteins during biosynthesis	35	9.37e-01	7.73e-03	9.82e-01
Degradation of AXIN	47	9.27e-01	7.72e-03	9.76e-01
Metabolism of lipids	543	7.70e-01	-7.43e-03	9.37e-01
Cargo recognition for clathrin-mediated endocytosis	76	9.14e-01	-7.15e-03	9.76e-01
G2/M Transition	154	8.79e-01	7.14e-03	9.69e-01
G-protein beta:gamma signalling	24	9.52e-01	-7.11e-03	9.85e-01
Regulation of TP53 Activity through Methylation	14	9.64e-01	-7.02e-03	9.91e-01
Signaling by RAF1 mutants	38	9.41e-01	-6.96e-03	9.82e-01
Hedgehog 'off' state	87	9.13e-01	-6.79e-03	9.76e-01
PTEN Regulation	130	8.95e-01	6.74e-03	9.70e-01
Acyl chain remodelling of PC	14	9.66e-01	6.62e-03	9.92e-01
ABC-family proteins mediated transport	83	9.17e-01	6.59e-03	9.76e-01
Hedgehog 'on' state	71	9.26e-01	6.36e-03	9.76e-01
MAP kinase activation	60	9.33e-01	-6.31e-03	9.80e-01
mRNA 3'-end processing	51	9.39e-01	-6.23e-03	9.82e-01
Asparagine N-linked glycosylation	241	8.70e-01	6.15e-03	9.65e-01
Long-term potentiation	11	9.73e-01	6.00e-03	9.92e-01
mRNA decay by 5' to 3' exoribonuclease	13	9.70e-01	5.99e-03	9.92e-01
TP53 Regulates Transcription of Cell Death Genes	33	9.55e-01	5.67e-03	9.85e-01
Regulation of TP53 Activity through Acetylation	29	9.58e-01	-5.65e-03	9.87e-01
Signaling by Insulin receptor	52	9.44e-01	-5.64e-03	9.83e-01
Synthesis of PIPs at the early endosome membrane	16	9.71e-01	-5.32e-03	9.92e-01
Negative regulation of FGFR1 signaling	20	9.67e-01	5.32e-03	9.92e-01
Regulation of insulin secretion	52	9.47e-01	5.31e-03	9.84e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	63	9.42e-01	5.30e-03	9.82e-01
Post-translational modification: synthesis of GPI-anchored proteins	41	9.54e-01	-5.20e-03	9.85e-01
Metabolism of polyamines	50	9.50e-01	-5.17e-03	9.84e-01
Aflatoxin activation and detoxification	10	9.78e-01	5.09e-03	9.93e-01
Signaling by FGFR	62	9.48e-01	4.83e-03	9.84e-01
Nucleotide salvage	19	9.71e-01	4.76e-03	9.92e-01
NIK-->noncanonical NF-kB signaling	50	9.54e-01	-4.75e-03	9.85e-01
Recruitment of NuMA to mitotic centrosomes	71	9.46e-01	-4.69e-03	9.83e-01
Signaling by WNT	209	9.19e-01	-4.11e-03	9.76e-01
Rab regulation of trafficking	112	9.42e-01	3.97e-03	9.82e-01
IGF1R signaling cascade	34	9.68e-01	3.95e-03	9.92e-01
PI-3K cascade:FGFR3	10	9.84e-01	-3.73e-03	9.95e-01
Protein-protein interactions at synapses	42	9.68e-01	-3.60e-03	9.92e-01
RNA Polymerase I Promoter Escape	29	9.74e-01	-3.51e-03	9.93e-01
MAP2K and MAPK activation	37	9.72e-01	3.39e-03	9.92e-01
Initiation of Nuclear Envelope (NE) Reformation	16	9.82e-01	-3.26e-03	9.95e-01
Activation of ATR in response to replication stress	28	9.77e-01	-3.13e-03	9.93e-01
RHO GTPases Activate Formins	84	9.64e-01	2.84e-03	9.91e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	29	9.80e-01	2.75e-03	9.94e-01
VEGFR2 mediated cell proliferation	18	9.84e-01	2.66e-03	9.95e-01
Ras activation upon Ca2+ influx through NMDA receptor	13	9.87e-01	-2.59e-03	9.95e-01
Chromatin modifying enzymes	182	9.54e-01	-2.47e-03	9.85e-01
Chromatin organization	182	9.54e-01	-2.47e-03	9.85e-01
Cell Cycle	492	9.35e-01	2.18e-03	9.80e-01
Loss of Nlp from mitotic centrosomes	60	9.77e-01	2.17e-03	9.93e-01
Loss of proteins required for interphase microtubule organization from the centrosome	60	9.77e-01	2.17e-03	9.93e-01
RET signaling	34	9.83e-01	2.11e-03	9.95e-01
Suppression of phagosomal maturation	11	9.91e-01	1.98e-03	9.97e-01
Netrin-1 signaling	39	9.86e-01	1.63e-03	9.95e-01
Synthesis of PIPs at the Golgi membrane	15	9.91e-01	1.60e-03	9.97e-01
EML4 and NUDC in mitotic spindle formation	64	9.84e-01	-1.44e-03	9.95e-01
Signaling by NOTCH4	73	9.87e-01	1.06e-03	9.95e-01
Generic Transcription Pathway	798	9.62e-01	1.01e-03	9.90e-01
PI Metabolism	76	9.89e-01	-9.13e-04	9.96e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	35	9.93e-01	-8.01e-04	9.97e-01
Antigen processing: Ubiquitination & Proteasome degradation	266	9.84e-01	7.04e-04	9.95e-01
Regulation of PTEN gene transcription	59	9.94e-01	-5.59e-04	9.97e-01
RAB GEFs exchange GTP for GDP on RABs	82	9.96e-01	-3.16e-04	9.98e-01
RNA Polymerase II Transcription	910	9.93e-01	-1.77e-04	9.97e-01
Negative regulators of DDX58/IFIH1 signaling	29	9.99e-01	1.74e-04	9.99e-01
SUMOylation of transcription cofactors	39	9.99e-01	-1.67e-04	9.99e-01
SHC-mediated cascade:FGFR4	11	1.00e+00	7.78e-06	1.00e+00

---

Detailed Gene set reports

Initial triggering of complement

Initial triggering of complement

	488
set	Initial triggering of complement
setSize	12
pANOVA	1.09e-05
s.dist	0.733
p.adjustANOVA	0.000924

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C3	5872.0
C1QC	5773.0
CFD	5771.0
C1QB	5471.0
C1R	5262.0
C2	5183.0
C4A	5061.5
C4B	5061.5
GZMM	4962.0
C1QA	4260.0
C1S	4244.0
MASP1	-4292.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C3	5872.0
C1QC	5773.0
CFD	5771.0
C1QB	5471.0
C1R	5262.0
C2	5183.0
C4A	5061.5
C4B	5061.5
GZMM	4962.0
C1QA	4260.0
C1S	4244.0
MASP1	-4292.0

---

Signal regulatory protein family interactions

Signal regulatory protein family interactions

	993
set	Signal regulatory protein family interactions
setSize	13
pANOVA	1.7e-05
s.dist	0.689
p.adjustANOVA	0.00136

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIRPA	5635.5
SIRPB1	5635.5
SIRPG	5635.5
SKAP2	5566.0
TYROBP	5517.0
PTPN6	4679.0
SRC	4543.0
PTK2	4451.0
FYB	4424.0
CD47	2522.0
GRB2	2230.0
PTK2B	1902.0
PTPN11	894.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIRPA	5635.5
SIRPB1	5635.5
SIRPG	5635.5
SKAP2	5566.0
TYROBP	5517.0
PTPN6	4679.0
SRC	4543.0
PTK2	4451.0
FYB	4424.0
CD47	2522.0
GRB2	2230.0
PTK2B	1902.0
PTPN11	894.0

---

Xenobiotics

Xenobiotics

	1236
set	Xenobiotics
setSize	14
pANOVA	1.94e-05
s.dist	-0.659
p.adjustANOVA	0.00145

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CYP2D6	-5698.0
CYP2C19	-5670.0
CYP2C8	-5670.0
CYP2C9	-5670.0
CYP3A4	-5039.5
CYP3A43	-5039.5
CYP3A5	-5039.5
CYP3A7	-5039.5
CYP2F1	-4471.0
CYP2E1	-4416.0
CYP2J2	-3037.0
ARNT2	-1033.0
AHR	328.0
ARNT	3024.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CYP2D6	-5698.0
CYP2C19	-5670.0
CYP2C8	-5670.0
CYP2C9	-5670.0
CYP3A4	-5039.5
CYP3A43	-5039.5
CYP3A5	-5039.5
CYP3A7	-5039.5
CYP2F1	-4471.0
CYP2E1	-4416.0
CYP2J2	-3037.0
ARNT2	-1033.0
AHR	328.0
ARNT	3024.0

---

Chemokine receptors bind chemokines

Chemokine receptors bind chemokines

	163
set	Chemokine receptors bind chemokines
setSize	16
pANOVA	0.000248
s.dist	0.529
p.adjustANOVA	0.00991

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCL2	5946.0
CCL7	5932.0
PF4	5905.5
CXCL10	5903.0
CX3CL1	5884.0
CXCL9	5863.0
CCR2	5740.0
ACKR2	5739.0
ACKR3	5487.0
CXCL12	4836.0
CCL11	2949.0
CCL25	1526.0
CXCL16	-1545.0
CXCR4	-2166.0
CCL27	-2599.0
CCL5	-4320.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCL2	5946.0
CCL7	5932.0
PF4	5905.5
CXCL10	5903.0
CX3CL1	5884.0
CXCL9	5863.0
CCR2	5740.0
ACKR2	5739.0
ACKR3	5487.0
CXCL12	4836.0
CCL11	2949.0
CCL25	1526.0
CXCL16	-1545.0
CXCR4	-2166.0
CCL27	-2599.0
CCL5	-4320.0

---

RIP-mediated NFkB activation via ZBP1

RIP-mediated NFkB activation via ZBP1

	823
set	RIP-mediated NFkB activation via ZBP1
setSize	17
pANOVA	0.000163
s.dist	0.528
p.adjustANOVA	0.00715

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ZBP1	5801
RELA	5784
NKIRAS2	5273
RIPK3	4623
NFKBIB	4525
CHUK	4512
NFKB2	4366
TLR3	4102
MYD88	4061
IKBKG	4052
NFKB1	2930
DHX9	2680
TICAM1	2510
NFKBIA	2079
IKBKB	679
RIPK1	-797
NKIRAS1	-3002

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ZBP1	5801
RELA	5784
NKIRAS2	5273
RIPK3	4623
NFKBIB	4525
CHUK	4512
NFKB2	4366
TLR3	4102
MYD88	4061
IKBKG	4052
NFKB1	2930
DHX9	2680
TICAM1	2510
NFKBIA	2079
IKBKB	679
RIPK1	-797
NKIRAS1	-3002

---

Plasma lipoprotein assembly

Plasma lipoprotein assembly

	757
set	Plasma lipoprotein assembly
setSize	15
pANOVA	0.000708
s.dist	-0.505
p.adjustANOVA	0.0203

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOE	-5741.0
MTTP	-5613.0
APOB	-5284.0
APOC4	-5090.5
APOC3	-5026.0
APOA2	-4650.0
APOC1	-4547.0
PRKACA	-3281.0
APOA1	-3195.0
PRKACB	-2638.0
SAR1B	-1875.0
BMP1	-1273.0
ABCA1	129.0
P4HB	394.0
ZDHHC8	4987.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOE	-5741.0
MTTP	-5613.0
APOB	-5284.0
APOC4	-5090.5
APOC3	-5026.0
APOA2	-4650.0
APOC1	-4547.0
PRKACA	-3281.0
APOA1	-3195.0
PRKACB	-2638.0
SAR1B	-1875.0
BMP1	-1273.0
ABCA1	129.0
P4HB	394.0
ZDHHC8	4987.0

---

Interleukin-4 and Interleukin-13 signaling

Interleukin-4 and Interleukin-13 signaling

	519
set	Interleukin-4 and Interleukin-13 signaling
setSize	73
pANOVA	1.79e-13
s.dist	0.499
p.adjustANOVA	1.14e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCL2	5946
CDKN1A	5945
JUNB	5943
MMP3	5927
SOCS3	5907
HMOX1	5883
F13A1	5867
IL4R	5861
MMP9	5837
FOS	5811
ANXA1	5796
LBP	5772
TWIST1	5744
ALOX5	5693
TIMP1	5648
TP53	5559
RHOU	5547
ITGB2	5540
STAT3	5528
JAK3	5515

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCL2	5946
CDKN1A	5945
JUNB	5943
MMP3	5927
SOCS3	5907
HMOX1	5883
F13A1	5867
IL4R	5861
MMP9	5837
FOS	5811
ANXA1	5796
LBP	5772
TWIST1	5744
ALOX5	5693
TIMP1	5648
TP53	5559
RHOU	5547
ITGB2	5540
STAT3	5528
JAK3	5515
MYC	5424
IL6R	5406
VIM	5386
RORC	5383
CCND1	5282
TNFRSF1B	5186
SOCS1	5145
HSP90AA1	5130
NDN	4998
ITGAM	4960
TGFB1	4845
IRF4	4832
NOS2	4633
AKT1	4605
ICAM1	4520
S1PR1	4402
HSPA8	4320
FOXO3	4136
SOCS5	4107
MMP2	3896
IL2RG	3873
IL13RA1	3816
ZEB1	3449
LCN2	3232
COL1A2	3027
CCL11	2949
ITGAX	2876
FN1	2783
LAMA5	2111
ITGB1	1955
VCAM1	1893
VEGFA	1839
HIF1A	1574
POU2F1	1301
FSCN1	1242
MCL1	821
HSP90B1	352
FOXO1	64
JAK1	58
PIM1	5
CD36	-91
TYK2	-218
STAT6	-226
BCL2	-1125
FGF2	-1726
STAT1	-1769
BCL6	-1820
JAK2	-3123
RORA	-3629
BCL2L1	-3915
MAOA	-4623
IL12A	-4707
PIK3R1	-5134

---

Cristae formation

Cristae formation

	202
set	Cristae formation
setSize	10
pANOVA	0.00729
s.dist	-0.49
p.adjustANOVA	0.0968

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOOL	-5506
MTX1	-5332
TMEM11	-3938
MTX2	-3852
IMMT	-3163
SAMM50	-1835
HSPA9	-1728
CHCHD3	-1326
CHCHD6	-1170
DNAJC11	245

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOOL	-5506
MTX1	-5332
TMEM11	-3938
MTX2	-3852
IMMT	-3163
SAMM50	-1835
HSPA9	-1728
CHCHD3	-1326
CHCHD6	-1170
DNAJC11	245

---

Cell recruitment (pro-inflammatory response)

Cell recruitment (pro-inflammatory response)

	150
set	Cell recruitment (pro-inflammatory response)
setSize	17
pANOVA	0.000508
s.dist	0.487
p.adjustANOVA	0.0162

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C3	5872
RELA	5784
CASP1	5720
C3AR1	5208
ENTPD1	4784
TXN	4603
P2RX4	4534
NFKB2	4366
HSP90AB1	4205
NT5E	3812
PSTPIP1	3682
NFKB1	2930
ENTPD5	1384
TXNIP	-44
P2RX7	-795
PYCARD	-2713
SUGT1	-3242

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C3	5872
RELA	5784
CASP1	5720
C3AR1	5208
ENTPD1	4784
TXN	4603
P2RX4	4534
NFKB2	4366
HSP90AB1	4205
NT5E	3812
PSTPIP1	3682
NFKB1	2930
ENTPD5	1384
TXNIP	-44
P2RX7	-795
PYCARD	-2713
SUGT1	-3242

---

Purinergic signaling in leishmaniasis infection

Purinergic signaling in leishmaniasis infection

	803
set	Purinergic signaling in leishmaniasis infection
setSize	17
pANOVA	0.000508
s.dist	0.487
p.adjustANOVA	0.0162

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C3	5872
RELA	5784
CASP1	5720
C3AR1	5208
ENTPD1	4784
TXN	4603
P2RX4	4534
NFKB2	4366
HSP90AB1	4205
NT5E	3812
PSTPIP1	3682
NFKB1	2930
ENTPD5	1384
TXNIP	-44
P2RX7	-795
PYCARD	-2713
SUGT1	-3242

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C3	5872
RELA	5784
CASP1	5720
C3AR1	5208
ENTPD1	4784
TXN	4603
P2RX4	4534
NFKB2	4366
HSP90AB1	4205
NT5E	3812
PSTPIP1	3682
NFKB1	2930
ENTPD5	1384
TXNIP	-44
P2RX7	-795
PYCARD	-2713
SUGT1	-3242

---

Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases

	41
set	Activation of Matrix Metalloproteinases
setSize	15
pANOVA	0.00219
s.dist	0.457
p.adjustANOVA	0.0432

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MMP3	5927
MMP9	5837
TPSAB1	5823
CMA1	5697
TIMP1	5648
TIMP2	4343
MMP15	4155
MMP2	3896
MMP14	2542
MMP11	2306
COL18A1	1804
CTSV	1798
FURIN	-636
CTSK	-1841
PLG	-5740

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MMP3	5927
MMP9	5837
TPSAB1	5823
CMA1	5697
TIMP1	5648
TIMP2	4343
MMP15	4155
MMP2	3896
MMP14	2542
MMP11	2306
COL18A1	1804
CTSV	1798
FURIN	-636
CTSK	-1841
PLG	-5740

---

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

	44
set	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
setSize	10
pANOVA	0.0137
s.dist	-0.45
p.adjustANOVA	0.142

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKAG3	-5691
MAPK12	-5052
MAPK11	-3856
PPARGC1A	-2915
PRKAG1	-2841
PRKAB2	-2446
PRKAB1	-1625
PRKAA2	-1561
MAPK14	-52
PRKAG2	754

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKAG3	-5691
MAPK12	-5052
MAPK11	-3856
PPARGC1A	-2915
PRKAG1	-2841
PRKAB2	-2446
PRKAB1	-1625
PRKAA2	-1561
MAPK14	-52
PRKAG2	754

---

The NLRP3 inflammasome

The NLRP3 inflammasome

	1140
set	The NLRP3 inflammasome
setSize	13
pANOVA	0.00606
s.dist	0.44
p.adjustANOVA	0.083

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RELA	5784
CASP1	5720
APP	5448
PANX1	4772
TXN	4603
NFKB2	4366
HSP90AB1	4205
PSTPIP1	3682
NFKB1	2930
TXNIP	-44
P2RX7	-795
PYCARD	-2713
SUGT1	-3242

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RELA	5784
CASP1	5720
APP	5448
PANX1	4772
TXN	4603
NFKB2	4366
HSP90AB1	4205
PSTPIP1	3682
NFKB1	2930
TXNIP	-44
P2RX7	-795
PYCARD	-2713
SUGT1	-3242

---

Interleukin-10 signaling

Interleukin-10 signaling

	510
set	Interleukin-10 signaling
setSize	19
pANOVA	0.000914
s.dist	0.439
p.adjustANOVA	0.0248

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCL2	5946.0
CXCL10	5903.0
CSF1	5893.0
IL1R2	5886.0
TNFRSF1A	5840.0
CCR2	5740.0
PTAFR	5706.0
TIMP1	5648.0
STAT3	5528.0
TNFRSF1B	5186.0
ICAM1	4520.0
IL10RB	1095.5
IL1R1	512.0
JAK1	58.0
TYK2	-218.0
IL10RA	-262.0
CD86	-3262.0
CCL5	-4320.0
IL12A	-4707.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCL2	5946.0
CXCL10	5903.0
CSF1	5893.0
IL1R2	5886.0
TNFRSF1A	5840.0
CCR2	5740.0
PTAFR	5706.0
TIMP1	5648.0
STAT3	5528.0
TNFRSF1B	5186.0
ICAM1	4520.0
IL10RB	1095.5
IL1R1	512.0
JAK1	58.0
TYK2	-218.0
IL10RA	-262.0
CD86	-3262.0
CCL5	-4320.0
IL12A	-4707.0

---

Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade

	267
set	Diseases associated with the TLR signaling cascade
setSize	19
pANOVA	0.00114
s.dist	0.431
p.adjustANOVA	0.0268

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RELA	5784
TLR4	5524
TLR5	4900
CHUK	4512
NFKB2	4366
TIRAP	4206
TLR3	4102
MYD88	4061
IKBKG	4052
TRAF3	3627
NFKB1	2930
TICAM1	2510
NFKBIA	2079
IKBKB	679
CD14	591
CD36	-91
IRAK4	-243
TLR6	-1411
TLR2	-2388

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RELA	5784
TLR4	5524
TLR5	4900
CHUK	4512
NFKB2	4366
TIRAP	4206
TLR3	4102
MYD88	4061
IKBKG	4052
TRAF3	3627
NFKB1	2930
TICAM1	2510
NFKBIA	2079
IKBKB	679
CD14	591
CD36	-91
IRAK4	-243
TLR6	-1411
TLR2	-2388

---

Diseases of Immune System

Diseases of Immune System

	268
set	Diseases of Immune System
setSize	19
pANOVA	0.00114
s.dist	0.431
p.adjustANOVA	0.0268

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RELA	5784
TLR4	5524
TLR5	4900
CHUK	4512
NFKB2	4366
TIRAP	4206
TLR3	4102
MYD88	4061
IKBKG	4052
TRAF3	3627
NFKB1	2930
TICAM1	2510
NFKBIA	2079
IKBKB	679
CD14	591
CD36	-91
IRAK4	-243
TLR6	-1411
TLR2	-2388

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RELA	5784
TLR4	5524
TLR5	4900
CHUK	4512
NFKB2	4366
TIRAP	4206
TLR3	4102
MYD88	4061
IKBKG	4052
TRAF3	3627
NFKB1	2930
TICAM1	2510
NFKBIA	2079
IKBKB	679
CD14	591
CD36	-91
IRAK4	-243
TLR6	-1411
TLR2	-2388

---

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

	357
set	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
setSize	10
pANOVA	0.0185
s.dist	0.43
p.adjustANOVA	0.16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	5945
HMGA1	5663
TP53	5559
RB1	4884
UBN1	3590
CABIN1	2781
LMNB1	694
ASF1A	598
EP400	-829
HIRA	-2718

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	5945
HMGA1	5663
TP53	5559
RB1	4884
UBN1	3590
CABIN1	2781
LMNB1	694
ASF1A	598
EP400	-829
HIRA	-2718

---

ZBP1(DAI) mediated induction of type I IFNs

ZBP1(DAI) mediated induction of type I IFNs

	1238
set	ZBP1(DAI) mediated induction of type I IFNs
setSize	20
pANOVA	0.001
s.dist	0.425
p.adjustANOVA	0.0258

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ZBP1	5801
RELA	5784
NKIRAS2	5273
RIPK3	4623
NFKBIB	4525
CHUK	4512
NFKB2	4366
TLR3	4102
MYD88	4061
IKBKG	4052
TBK1	3279
NFKB1	2930
DHX9	2680
TICAM1	2510
NFKBIA	2079
IKBKB	679
DTX4	-630
RIPK1	-797
NKIRAS1	-3002
IRF3	-5162

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ZBP1	5801
RELA	5784
NKIRAS2	5273
RIPK3	4623
NFKBIB	4525
CHUK	4512
NFKB2	4366
TLR3	4102
MYD88	4061
IKBKG	4052
TBK1	3279
NFKB1	2930
DHX9	2680
TICAM1	2510
NFKBIA	2079
IKBKB	679
DTX4	-630
RIPK1	-797
NKIRAS1	-3002
IRF3	-5162

---

Defective B4GALT7 causes EDS, progeroid type

Defective B4GALT7 causes EDS, progeroid type

	237
set	Defective B4GALT7 causes EDS, progeroid type
setSize	15
pANOVA	0.0048
s.dist	0.421
p.adjustANOVA	0.0711

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VCAN	5645
BGN	5425
SDC4	5232
SDC3	5177
DCN	5146
GPC6	4666
HSPG2	4308
GPC4	3765
B4GALT7	1806
GPC1	1506
GPC3	1179
SDC1	-148
CSPG4	-383
SDC2	-2418
AGRN	-2522

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VCAN	5645
BGN	5425
SDC4	5232
SDC3	5177
DCN	5146
GPC6	4666
HSPG2	4308
GPC4	3765
B4GALT7	1806
GPC1	1506
GPC3	1179
SDC1	-148
CSPG4	-383
SDC2	-2418
AGRN	-2522

---

Interleukin-37 signaling

Interleukin-37 signaling

	518
set	Interleukin-37 signaling
setSize	17
pANOVA	0.00292
s.dist	0.417
p.adjustANOVA	0.0509

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CASP1	5720
IL18BP	5677
STAT3	5528
PTPN7	5494
PTPN14	5020
PTPN6	4679
PTPN12	3420
TBK1	3279
PTPN23	3266
PTPN9	1505
PTPN13	1416
PTPN18	1135
SIGIRR	1080
PTPN11	894
PTPN4	-168
SMAD3	-1322
PTPN2	-3485

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CASP1	5720
IL18BP	5677
STAT3	5528
PTPN7	5494
PTPN14	5020
PTPN6	4679
PTPN12	3420
TBK1	3279
PTPN23	3266
PTPN9	1505
PTPN13	1416
PTPN18	1135
SIGIRR	1080
PTPN11	894
PTPN4	-168
SMAD3	-1322
PTPN2	-3485

---

PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair

	716
set	PCNA-Dependent Long Patch Base Excision Repair
setSize	19
pANOVA	0.00202
s.dist	-0.409
p.adjustANOVA	0.0422

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLE3	-5374
RFC1	-5119
RFC3	-4978
RPA2	-4884
RFC4	-4574
POLD4	-4088
RPA3	-3737
RPA1	-3597
RFC5	-2851
POLE4	-2203
POLB	-1553
POLD3	-1469
RFC2	-1083
PCNA	-971
POLE	-140
APEX1	-128
POLD2	715
LIG1	904
POLD1	1697

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLE3	-5374
RFC1	-5119
RFC3	-4978
RPA2	-4884
RFC4	-4574
POLD4	-4088
RPA3	-3737
RPA1	-3597
RFC5	-2851
POLE4	-2203
POLB	-1553
POLD3	-1469
RFC2	-1083
PCNA	-971
POLE	-140
APEX1	-128
POLD2	715
LIG1	904
POLD1	1697

---

Translesion synthesis by REV1

Translesion synthesis by REV1

	1188
set	Translesion synthesis by REV1
setSize	14
pANOVA	0.00816
s.dist	-0.408
p.adjustANOVA	0.104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFC1	-5119
RFC3	-4978
RPA2	-4884
REV3L	-4795
RFC4	-4574
UBC	-4096
RPA3	-3737
RPA1	-3597
RFC5	-2851
RFC2	-1083
PCNA	-971
REV1	2051
MAD2L2	2385
RPS27A	4294

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFC1	-5119
RFC3	-4978
RPA2	-4884
REV3L	-4795
RFC4	-4574
UBC	-4096
RPA3	-3737
RPA1	-3597
RFC5	-2851
RFC2	-1083
PCNA	-971
REV1	2051
MAD2L2	2385
RPS27A	4294

---

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

	68
set	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize	17
pANOVA	0.00485
s.dist	0.395
p.adjustANOVA	0.0711

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAP2	5902
PDIA3	5391
TAP1	5376
B2M	5335
TAPBP	4936
SEC31A	4699
HSPA5	4665
SEC24D	4398
SEC24C	3758
CALR	2782
CANX	1251
SEC13	955
SEC24B	302
SEC23A	-114
SAR1B	-1875
ERAP1	-2285
SEC24A	-4559

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAP2	5902
PDIA3	5391
TAP1	5376
B2M	5335
TAPBP	4936
SEC31A	4699
HSPA5	4665
SEC24D	4398
SEC24C	3758
CALR	2782
CANX	1251
SEC13	955
SEC24B	302
SEC23A	-114
SAR1B	-1875
ERAP1	-2285
SEC24A	-4559

---

Synthesis of IP2, IP, and Ins in the cytosol

Synthesis of IP2, IP, and Ins in the cytosol

	1086
set	Synthesis of IP2, IP, and Ins in the cytosol
setSize	12
pANOVA	0.0184
s.dist	0.393
p.adjustANOVA	0.16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTMR9	5692
INPP5A	5582
SYNJ1	4886
IMPA2	3818
INPP5B	3434
INPP5J	3138
ISYNA1	2463
INPP1	1709
INPP4B	1166
INPP4A	121
IMPA1	-13
OCRL	-3216

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTMR9	5692
INPP5A	5582
SYNJ1	4886
IMPA2	3818
INPP5B	3434
INPP5J	3138
ISYNA1	2463
INPP1	1709
INPP4B	1166
INPP4A	121
IMPA1	-13
OCRL	-3216

---

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

	605
set	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
setSize	13
pANOVA	0.0148
s.dist	-0.391
p.adjustANOVA	0.145

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MLH1	-5562
RPA2	-4884
MSH3	-4253
POLD4	-4088
RPA3	-3737
RPA1	-3597
PMS2	-2900
POLD3	-1469
PCNA	-971
MSH2	-183
POLD2	715
LIG1	904
POLD1	1697

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MLH1	-5562
RPA2	-4884
MSH3	-4253
POLD4	-4088
RPA3	-3737
RPA1	-3597
PMS2	-2900
POLD3	-1469
PCNA	-971
MSH2	-183
POLD2	715
LIG1	904
POLD1	1697

---

FCGR activation

FCGR activation

	331
set	FCGR activation
setSize	10
pANOVA	0.0325
s.dist	0.39
p.adjustANOVA	0.231

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FYN	5329.0
FCGR1A	5223.5
FCGR2A	5002.5
SRC	4543.0
FGR	3790.0
YES1	3560.0
HCK	2214.0
SYK	77.0
CD247	-2385.0
LYN	-3519.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FYN	5329.0
FCGR1A	5223.5
FCGR2A	5002.5
SRC	4543.0
FGR	3790.0
YES1	3560.0
HCK	2214.0
SYK	77.0
CD247	-2385.0
LYN	-3519.0

---

Post-chaperonin tubulin folding pathway

Post-chaperonin tubulin folding pathway

	771
set	Post-chaperonin tubulin folding pathway
setSize	15
pANOVA	0.00929
s.dist	0.388
p.adjustANOVA	0.113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBB6	5939
TUBB4B	5849
TUBB2A	5349
TUBB4A	4765
TUBA4A	4655
TUBA8	4438
TUBA1A	4218
TBCD	2605
TUBA1C	1634
TBCA	976
TUBA1B	471
TBCE	285
TBCC	140
TBCB	-2704
ARL2	-3098

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBB6	5939
TUBB4B	5849
TUBB2A	5349
TUBB4A	4765
TUBA4A	4655
TUBA8	4438
TUBA1A	4218
TBCD	2605
TUBA1C	1634
TBCA	976
TUBA1B	471
TBCE	285
TBCC	140
TBCB	-2704
ARL2	-3098

---

Adenylate cyclase inhibitory pathway

Adenylate cyclase inhibitory pathway

	56
set	Adenylate cyclase inhibitory pathway
setSize	12
pANOVA	0.0219
s.dist	0.382
p.adjustANOVA	0.18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY9	5618
GNAI2	5184
ADCY6	4753
GNAI1	4264
ADCY1	3962
ADCY3	3318
GNAI3	2947
GNAL	1503
ADCY7	470
ADCY5	-694
ADCY4	-922
ADCY2	-2376

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY9	5618
GNAI2	5184
ADCY6	4753
GNAI1	4264
ADCY1	3962
ADCY3	3318
GNAI3	2947
GNAL	1503
ADCY7	470
ADCY5	-694
ADCY4	-922
ADCY2	-2376

---

Translesion synthesis by POLI

Translesion synthesis by POLI

	1186
set	Translesion synthesis by POLI
setSize	15
pANOVA	0.0107
s.dist	-0.381
p.adjustANOVA	0.124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFC1	-5119
RFC3	-4978
RPA2	-4884
REV3L	-4795
RFC4	-4574
UBC	-4096
RPA3	-3737
RPA1	-3597
RFC5	-2851
RFC2	-1083
PCNA	-971
POLI	138
REV1	2051
MAD2L2	2385
RPS27A	4294

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFC1	-5119
RFC3	-4978
RPA2	-4884
REV3L	-4795
RFC4	-4574
UBC	-4096
RPA3	-3737
RPA1	-3597
RFC5	-2851
RFC2	-1083
PCNA	-971
POLI	138
REV1	2051
MAD2L2	2385
RPS27A	4294

---

Mitochondrial tRNA aminoacylation

Mitochondrial tRNA aminoacylation

	613
set	Mitochondrial tRNA aminoacylation
setSize	18
pANOVA	0.00528
s.dist	-0.38
p.adjustANOVA	0.0756

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TARS2	-5335.0
SARS2	-4530.5
DARS2	-4403.0
NARS2	-4375.0
IARS2	-3817.0
HARS2	-2665.0
AARS2	-2485.0
YARS2	-2470.0
FARS2	-2335.0
VARS2	-2004.0
WARS2	-1922.0
LARS2	-1897.0
PPA2	-1628.0
RARS2	-1230.0
CARS2	-625.0
MARS2	-9.0
EARS2	385.0
PARS2	3274.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TARS2	-5335.0
SARS2	-4530.5
DARS2	-4403.0
NARS2	-4375.0
IARS2	-3817.0
HARS2	-2665.0
AARS2	-2485.0
YARS2	-2470.0
FARS2	-2335.0
VARS2	-2004.0
WARS2	-1922.0
LARS2	-1897.0
PPA2	-1628.0
RARS2	-1230.0
CARS2	-625.0
MARS2	-9.0
EARS2	385.0
PARS2	3274.0

---

Defective B3GAT3 causes JDSSDHD

Defective B3GAT3 causes JDSSDHD

	236
set	Defective B3GAT3 causes JDSSDHD
setSize	15
pANOVA	0.0109
s.dist	0.38
p.adjustANOVA	0.125

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VCAN	5645
BGN	5425
SDC4	5232
SDC3	5177
DCN	5146
GPC6	4666
HSPG2	4308
GPC4	3765
GPC1	1506
GPC3	1179
SDC1	-148
CSPG4	-383
B3GAT3	-1773
SDC2	-2418
AGRN	-2522

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VCAN	5645
BGN	5425
SDC4	5232
SDC3	5177
DCN	5146
GPC6	4666
HSPG2	4308
GPC4	3765
GPC1	1506
GPC3	1179
SDC1	-148
CSPG4	-383
B3GAT3	-1773
SDC2	-2418
AGRN	-2522

---

Cell-extracellular matrix interactions

Cell-extracellular matrix interactions

	154
set	Cell-extracellular matrix interactions
setSize	15
pANOVA	0.011
s.dist	0.379
p.adjustANOVA	0.125

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FLNC	5737.0
LIMS2	5169.0
TESK1	4909.0
ACTN1	4787.0
LIMS1	3223.5
PXN	2340.0
PARVB	2319.0
VASP	2202.0
RSU1	2027.0
ITGB1	1955.0
PARVA	1774.0
FERMT2	950.0
FBLIM1	654.0
FLNA	-453.0
ARHGEF6	-2819.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FLNC	5737.0
LIMS2	5169.0
TESK1	4909.0
ACTN1	4787.0
LIMS1	3223.5
PXN	2340.0
PARVB	2319.0
VASP	2202.0
RSU1	2027.0
ITGB1	1955.0
PARVA	1774.0
FERMT2	950.0
FBLIM1	654.0
FLNA	-453.0
ARHGEF6	-2819.0

---

Regulation of Complement cascade

Regulation of Complement cascade

	876
set	Regulation of Complement cascade
setSize	24
pANOVA	0.0013
s.dist	0.379
p.adjustANOVA	0.029

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C3	5872.0
SERPING1	5826.0
C7	5809.0
C1QC	5773.0
C5AR1	5643.0
C1QB	5471.0
C1R	5262.0
C3AR1	5208.0
C2	5183.0
C4A	5061.5
C4B	5061.5
CFH	5012.0
C1QA	4260.0
C1S	4244.0
CD59	4236.0
PROS1	3026.0
CD81	421.0
CR1	196.5
CD46	-647.0
CLU	-2903.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C3	5872.0
SERPING1	5826.0
C7	5809.0
C1QC	5773.0
C5AR1	5643.0
C1QB	5471.0
C1R	5262.0
C3AR1	5208.0
C2	5183.0
C4A	5061.5
C4B	5061.5
CFH	5012.0
C1QA	4260.0
C1S	4244.0
CD59	4236.0
PROS1	3026.0
CD81	421.0
CR1	196.5
CD46	-647.0
CLU	-2903.0
CD55	-5486.0
VTN	-5595.0
C8G	-5641.0
F2	-5707.0

---

Removal of the Flap Intermediate from the C-strand

Removal of the Flap Intermediate from the C-strand

	921
set	Removal of the Flap Intermediate from the C-strand
setSize	16
pANOVA	0.00866
s.dist	-0.379
p.adjustANOVA	0.108

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WRN	-5410
TERF1	-5308
RPA2	-4884
POT1	-4685
POLD4	-4088
TINF2	-4078
TERF2	-3831
RPA3	-3737
RPA1	-3597
TERF2IP	-2551
POLD3	-1469
PCNA	-971
POLD2	715
POLD1	1697
DNA2	3285
ACD	5127

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WRN	-5410
TERF1	-5308
RPA2	-4884
POT1	-4685
POLD4	-4088
TINF2	-4078
TERF2	-3831
RPA3	-3737
RPA1	-3597
TERF2IP	-2551
POLD3	-1469
PCNA	-971
POLD2	715
POLD1	1697
DNA2	3285
ACD	5127

---

Striated Muscle Contraction

Striated Muscle Contraction

	1077
set	Striated Muscle Contraction
setSize	31
pANOVA	0.000267
s.dist	-0.378
p.adjustANOVA	0.01

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYH8	-5589
TMOD4	-5523
TNNI1	-5424
TNNT2	-5326
MYL4	-5217
TPM1	-5216
TPM2	-5163
MYL1	-5115
TNNI2	-5006
MYBPC2	-4972
TNNT3	-4917
TNNC2	-4861
TNNT1	-4853
TCAP	-4545
MYH6	-3989
MYBPC1	-3929
TNNC1	-3794
MYH3	-3493
DMD	-2606
MYL3	-1989

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYH8	-5589
TMOD4	-5523
TNNI1	-5424
TNNT2	-5326
MYL4	-5217
TPM1	-5216
TPM2	-5163
MYL1	-5115
TNNI2	-5006
MYBPC2	-4972
TNNT3	-4917
TNNC2	-4861
TNNT1	-4853
TCAP	-4545
MYH6	-3989
MYBPC1	-3929
TNNC1	-3794
MYH3	-3493
DMD	-2606
MYL3	-1989
TTN	-1612
ACTN2	-868
NEB	-141
TMOD3	450
DES	1263
TMOD1	2476
TMOD2	3495
TPM3	4929
TPM4	5008
VIM	5386
MYL2	5909

---

Complement cascade

Complement cascade

	187
set	Complement cascade
setSize	27
pANOVA	0.000718
s.dist	0.376
p.adjustANOVA	0.0203

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C3	5872.0
SERPING1	5826.0
C7	5809.0
C1QC	5773.0
CFD	5771.0
C5AR1	5643.0
C1QB	5471.0
C1R	5262.0
C3AR1	5208.0
C2	5183.0
C4A	5061.5
C4B	5061.5
CFH	5012.0
GZMM	4962.0
C1QA	4260.0
C1S	4244.0
CD59	4236.0
PROS1	3026.0
CD81	421.0
CR1	196.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C3	5872.0
SERPING1	5826.0
C7	5809.0
C1QC	5773.0
CFD	5771.0
C5AR1	5643.0
C1QB	5471.0
C1R	5262.0
C3AR1	5208.0
C2	5183.0
C4A	5061.5
C4B	5061.5
CFH	5012.0
GZMM	4962.0
C1QA	4260.0
C1S	4244.0
CD59	4236.0
PROS1	3026.0
CD81	421.0
CR1	196.5
CD46	-647.0
CLU	-2903.0
MASP1	-4292.0
CD55	-5486.0
VTN	-5595.0
C8G	-5641.0
F2	-5707.0

---

Interleukin-15 signaling

Interleukin-15 signaling

	513
set	Interleukin-15 signaling
setSize	13
pANOVA	0.0207
s.dist	0.371
p.adjustANOVA	0.173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT3	5528
JAK3	5515
GAB2	3981
IL2RG	3873
SHC1	3146
STAT5B	2521
STAT5A	2347
GRB2	2230
SOS2	1704
IL15	889
JAK1	58
SOS1	-567
IL15RA	-1760

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT3	5528
JAK3	5515
GAB2	3981
IL2RG	3873
SHC1	3146
STAT5B	2521
STAT5A	2347
GRB2	2230
SOS2	1704
IL15	889
JAK1	58
SOS1	-567
IL15RA	-1760

---

Defective B3GALT6 causes EDSP2 and SEMDJL1

Defective B3GALT6 causes EDSP2 and SEMDJL1

	234
set	Defective B3GALT6 causes EDSP2 and SEMDJL1
setSize	15
pANOVA	0.0137
s.dist	0.368
p.adjustANOVA	0.142

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VCAN	5645
BGN	5425
SDC4	5232
SDC3	5177
DCN	5146
GPC6	4666
HSPG2	4308
GPC4	3765
GPC1	1506
GPC3	1179
SDC1	-148
CSPG4	-383
SDC2	-2418
AGRN	-2522
B3GALT6	-2830

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VCAN	5645
BGN	5425
SDC4	5232
SDC3	5177
DCN	5146
GPC6	4666
HSPG2	4308
GPC4	3765
GPC1	1506
GPC3	1179
SDC1	-148
CSPG4	-383
SDC2	-2418
AGRN	-2522
B3GALT6	-2830

---

Mitochondrial calcium ion transport

Mitochondrial calcium ion transport

	610
set	Mitochondrial calcium ion transport
setSize	21
pANOVA	0.00374
s.dist	-0.366
p.adjustANOVA	0.0589

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VDAC3	-5383
MICU3	-5175
MCU	-4906
PMPCB	-4689
PHB	-4218
STOML2	-3536
SLC8A3	-3101
VDAC2	-2905
SMDT1	-2701
YME1L1	-2431
VDAC1	-2323
MICU1	-2236
LETM1	-2183
SPG7	-1778
PARL	-1667
MICU2	-1229
C2orf47	-543
AFG3L2	-162
PMPCA	1841
AKAP1	3228

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VDAC3	-5383
MICU3	-5175
MCU	-4906
PMPCB	-4689
PHB	-4218
STOML2	-3536
SLC8A3	-3101
VDAC2	-2905
SMDT1	-2701
YME1L1	-2431
VDAC1	-2323
MICU1	-2236
LETM1	-2183
SPG7	-1778
PARL	-1667
MICU2	-1229
C2orf47	-543
AFG3L2	-162
PMPCA	1841
AKAP1	3228
PHB2	3448

---

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

	924
set	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize	22
pANOVA	0.0033
s.dist	-0.362
p.adjustANOVA	0.0546

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLE3	-5374
RFC1	-5119
PARP2	-5034
RFC3	-4978
RPA2	-4884
RFC4	-4574
POLD4	-4088
RPA3	-3737
RPA1	-3597
RFC5	-2851
POLE4	-2203
POLB	-1553
POLD3	-1469
RFC2	-1083
PCNA	-971
POLE	-140
APEX1	-128
POLD2	715
LIG1	904
PARP1	1572

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLE3	-5374
RFC1	-5119
PARP2	-5034
RFC3	-4978
RPA2	-4884
RFC4	-4574
POLD4	-4088
RPA3	-3737
RPA1	-3597
RFC5	-2851
POLE4	-2203
POLB	-1553
POLD3	-1469
RFC2	-1083
PCNA	-971
POLE	-140
APEX1	-128
POLD2	715
LIG1	904
PARP1	1572
POLD1	1697
PARG	2674

---

Processing of SMDT1

Processing of SMDT1

	788
set	Processing of SMDT1
setSize	15
pANOVA	0.0158
s.dist	-0.36
p.adjustANOVA	0.149

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MICU3	-5175
MCU	-4906
PMPCB	-4689
PHB	-4218
STOML2	-3536
SMDT1	-2701
YME1L1	-2431
MICU1	-2236
SPG7	-1778
PARL	-1667
MICU2	-1229
C2orf47	-543
AFG3L2	-162
PMPCA	1841
PHB2	3448

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MICU3	-5175
MCU	-4906
PMPCB	-4689
PHB	-4218
STOML2	-3536
SMDT1	-2701
YME1L1	-2431
MICU1	-2236
SPG7	-1778
PARL	-1667
MICU2	-1229
C2orf47	-543
AFG3L2	-162
PMPCA	1841
PHB2	3448

---

Mitochondrial protein import

Mitochondrial protein import

	612
set	Mitochondrial protein import
setSize	56
pANOVA	3.49e-06
s.dist	-0.359
p.adjustANOVA	0.000405

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TIMM9	-5574
TIMM44	-5432
TAZ	-5344
MTX1	-5332
COX19	-5190
CHCHD2	-4913
TIMM17B	-4693
PMPCB	-4689
DNAJC19	-4634
GRPEL2	-4602
COX17	-4594
TIMM22	-4528
NDUFB8	-4491
CMC2	-4432
TIMM13	-4355
TIMM17A	-4108
TIMM50	-3954
TIMM21	-3884
MTX2	-3852
SLC25A4	-3773

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TIMM9	-5574.0
TIMM44	-5432.0
TAZ	-5344.0
MTX1	-5332.0
COX19	-5190.0
CHCHD2	-4913.0
TIMM17B	-4693.0
PMPCB	-4689.0
DNAJC19	-4634.0
GRPEL2	-4602.0
COX17	-4594.0
TIMM22	-4528.0
NDUFB8	-4491.0
CMC2	-4432.0
TIMM13	-4355.0
TIMM17A	-4108.0
TIMM50	-3954.0
TIMM21	-3884.0
MTX2	-3852.0
SLC25A4	-3773.0
IDH3G	-3771.0
FXN	-3600.0
TIMM10B	-3522.0
TOMM40	-3362.0
TOMM22	-2562.0
CYC1	-2530.0
SLC25A12	-2390.0
CHCHD7	-2359.0
VDAC1	-2323.0
COA4	-2147.0
LDHD	-2119.0
TIMM10	-1993.0
SAMM50	-1835.0
GRPEL1	-1783.0
HSPA9	-1728.0
PAM16	-1502.0
COQ2	-1362.0
CHCHD3	-1326.0
TIMM23	-1011.5
TOMM7	-884.0
CS	-851.0
CHCHD5	-505.0
ACO2	440.0
PITRM1	491.0
CHCHD4	840.0
BCS1L	1094.0
GFER	1187.0
TIMM8B	1240.0
HSPD1	1417.0
PMPCA	1841.0
CHCHD10	2028.0
TOMM20	2356.0
TOMM5	2581.0
CMC4	2734.0
HSCB	3530.0
COA6	4923.0

---

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

	1271
set	tRNA processing in the mitochondrion
setSize	11
pANOVA	0.0404
s.dist	0.357
p.adjustANOVA	0.259

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND5	5668
MT-CO1	5486
MT-ND2	5332
MT-CYB	4433
MT-ND1	3455
MT-ND4	2169
TRNT1	2112
MT-ND6	1064
HSD17B10	343
ELAC2	-1660
TRMT10C	-4342

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND5	5668
MT-CO1	5486
MT-ND2	5332
MT-CYB	4433
MT-ND1	3455
MT-ND4	2169
TRNT1	2112
MT-ND6	1064
HSD17B10	343
ELAC2	-1660
TRMT10C	-4342

---

Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs

	104
set	Biosynthesis of DHA-derived SPMs
setSize	12
pANOVA	0.0337
s.dist	-0.354
p.adjustANOVA	0.235

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CYP2D6	-5698.0
CYP2C8	-5670.0
CYP2C9	-5670.0
CYP3A4	-5039.5
ALOX12	-5005.0
CYP2E1	-4416.0
GSTM4	-3355.0
GPX4	-2384.0
EPHX2	-856.0
LTA4H	3195.0
HPGD	5617.0
ALOX5	5693.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CYP2D6	-5698.0
CYP2C8	-5670.0
CYP2C9	-5670.0
CYP3A4	-5039.5
ALOX12	-5005.0
CYP2E1	-4416.0
GSTM4	-3355.0
GPX4	-2384.0
EPHX2	-856.0
LTA4H	3195.0
HPGD	5617.0
ALOX5	5693.0

---

AKT phosphorylates targets in the cytosol

AKT phosphorylates targets in the cytosol

	8
set	AKT phosphorylates targets in the cytosol
setSize	14
pANOVA	0.0226
s.dist	0.352
p.adjustANOVA	0.183

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	5945.0
AKT1	4605.0
AKT3	4518.0
CHUK	4512.0
MDM2	3934.0
BAD	3650.0
GSK3B	2427.0
MKRN1	1383.0
GSK3A	939.5
TSC2	545.0
CASP9	347.0
AKT2	120.0
AKT1S1	-326.0
CDKN1B	-2373.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	5945.0
AKT1	4605.0
AKT3	4518.0
CHUK	4512.0
MDM2	3934.0
BAD	3650.0
GSK3B	2427.0
MKRN1	1383.0
GSK3A	939.5
TSC2	545.0
CASP9	347.0
AKT2	120.0
AKT1S1	-326.0
CDKN1B	-2373.0

---

Methylation

Methylation

	601
set	Methylation
setSize	12
pANOVA	0.0354
s.dist	-0.351
p.adjustANOVA	0.241

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AHCY	-5681
MAT2A	-5437
MAT1A	-4998
TPMT	-4352
N6AMT1	-4105
AS3MT	-3949
MAT2B	-3763
COMT	-345
MTR	1067
GSTO1	1129
NNMT	3404
MTRR	3669

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AHCY	-5681
MAT2A	-5437
MAT1A	-4998
TPMT	-4352
N6AMT1	-4105
AS3MT	-3949
MAT2B	-3763
COMT	-345
MTR	1067
GSTO1	1129
NNMT	3404
MTRR	3669

---

Interferon alpha/beta signaling

Interferon alpha/beta signaling

	505
set	Interferon alpha/beta signaling
setSize	40
pANOVA	0.000137
s.dist	0.349
p.adjustANOVA	0.007

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFITM1	5913
IFITM2	5913
IFITM3	5913
SOCS3	5907
OAS2	5736
IRF5	5622
IRF9	5564
SAMHD1	5268
SOCS1	5145
STAT2	5077
IRF1	5033
PSMB8	4990
IRF4	4832
IRF2	4825
PTPN6	4679
RNASEL	3822
PTPN1	3681
EGR1	3582
IFNAR2	3097
XAF1	2880

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFITM1	5913.0
IFITM2	5913.0
IFITM3	5913.0
SOCS3	5907.0
OAS2	5736.0
IRF5	5622.0
IRF9	5564.0
SAMHD1	5268.0
SOCS1	5145.0
STAT2	5077.0
IRF1	5033.0
PSMB8	4990.0
IRF4	4832.0
IRF2	4825.0
PTPN6	4679.0
RNASEL	3822.0
PTPN1	3681.0
EGR1	3582.0
IFNAR2	3097.0
XAF1	2880.0
IRF8	2675.0
ADAR	2549.0
BST2	2537.0
IFNAR1	2439.0
IFI35	2007.0
ISG20	925.0
PTPN11	894.0
JAK1	58.0
TYK2	-218.0
IFIT3	-277.0
IFI27	-381.0
RSAD2	-1599.0
STAT1	-1769.0
IFIT2	-1770.0
IRF7	-2069.0
ABCE1	-2182.0
IP6K2	-2229.0
USP18	-4060.5
ISG15	-4499.0
IRF3	-5162.0

---

Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)

	172
set	Citric acid cycle (TCA cycle)
setSize	22
pANOVA	0.00486
s.dist	-0.347
p.adjustANOVA	0.0711

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SUCLG2	-5348
FAHD1	-5101
SUCLG1	-3962
IDH3G	-3771
SUCLA2	-3191
MDH2	-3089
ME3	-3033
FH	-2925
SDHA	-2824
DLD	-2805
IDH3A	-2667
IDH3B	-2370
SDHB	-2281
DLST	-1804
SDHD	-1479
NNT	-1171
CS	-851
IDH2	-615
ACO2	440
SDHC	1075

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SUCLG2	-5348
FAHD1	-5101
SUCLG1	-3962
IDH3G	-3771
SUCLA2	-3191
MDH2	-3089
ME3	-3033
FH	-2925
SDHA	-2824
DLD	-2805
IDH3A	-2667
IDH3B	-2370
SDHB	-2281
DLST	-1804
SDHD	-1479
NNT	-1171
CS	-851
IDH2	-615
ACO2	440
SDHC	1075
OGDH	2399
ME2	3080

---

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

	475
set	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
setSize	33
pANOVA	0.000625
s.dist	0.344
p.adjustANOVA	0.0189

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LILRB4	5918.0
IFITM1	5913.0
C3	5872.0
CD300LB	5851.0
SIGLEC1	5798.0
ITGB2	5540.0
TYROBP	5517.0
CD34	5442.0
B2M	5335.0
FCGR1A	5223.5
CD300LD	5128.5
CD300LF	5128.5
FCGR2B	5002.5
CD40	4550.0
ICAM1	4520.0
NPDC1	3865.0
COLEC12	3406.0
ITGA4	3320.0
ITGAL	3258.0
ITGB7	3119.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LILRB4	5918.0
IFITM1	5913.0
C3	5872.0
CD300LB	5851.0
SIGLEC1	5798.0
ITGB2	5540.0
TYROBP	5517.0
CD34	5442.0
B2M	5335.0
FCGR1A	5223.5
CD300LD	5128.5
CD300LF	5128.5
FCGR2B	5002.5
CD40	4550.0
ICAM1	4520.0
NPDC1	3865.0
COLEC12	3406.0
ITGA4	3320.0
ITGAL	3258.0
ITGB7	3119.0
CD1D	2877.0
ITGB1	1955.0
VCAM1	1893.0
CD81	421.0
CD300LG	359.0
CD247	-2385.0
ICAM2	-3782.0
CD200	-4016.0
PIANP	-4540.0
TREM2	-4736.0
ICAM4	-5185.0
CD300A	-5476.5
CD300C	-5476.5

---

Peroxisomal lipid metabolism

Peroxisomal lipid metabolism

	749
set	Peroxisomal lipid metabolism
setSize	24
pANOVA	0.00367
s.dist	-0.343
p.adjustANOVA	0.0584

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC27A2	-5712
NUDT19	-5395
ACBD4	-5358
NUDT7	-4866
DECR2	-4803
AMACR	-4705
CROT	-4441
PECR	-4408
PHYH	-3986
HACL1	-3694
ALDH3A2	-3402
ABCD1	-2803
ECI2	-2369
HSD17B4	-2074
SCP2	-1251
ACOX3	-689
MLYCD	73
ACOX1	382
ACOT8	611
CRAT	1472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC27A2	-5712
NUDT19	-5395
ACBD4	-5358
NUDT7	-4866
DECR2	-4803
AMACR	-4705
CROT	-4441
PECR	-4408
PHYH	-3986
HACL1	-3694
ALDH3A2	-3402
ABCD1	-2803
ECI2	-2369
HSD17B4	-2074
SCP2	-1251
ACOX3	-689
MLYCD	73
ACOX1	382
ACOT8	611
CRAT	1472
ACBD5	2042
EHHADH	2480
SLC25A17	3074
ACOT6	4283

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] MASS_7.3-51.6               fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [49] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [52] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [55] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [58] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [61] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [64] evaluate_0.14          lattice_0.20-41        htmlwidgets_1.5.1     
## [67] bit_1.1-15.2           tidyselect_1.1.0       plyr_1.8.6            
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          locfit_1.5-9.4         grid_4.0.2            
## [85] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [88] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [91] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report