date generated: 2020-07-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  x
## A4GALT  1.21526264
## AAAS   -0.15967183
## AACS   -0.26770637
## AAED1  -0.26129262
## AAGAB  -0.14127424
## AAK1   -0.08861407

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 11694
duplicated_genes_present 0
num_profile_genes_in_sets 6733
num_profile_genes_not_in_sets 4961

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1126
num_genesets_included 1274

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set setSize pANOVA s.dist p.adjustANOVA
Initial triggering of complement 12 1.09e-05 0.733 9.24e-04
Signal regulatory protein family interactions 13 1.70e-05 0.689 1.36e-03
Xenobiotics 14 1.94e-05 -0.659 1.45e-03
Chemokine receptors bind chemokines 16 2.48e-04 0.529 9.91e-03
RIP-mediated NFkB activation via ZBP1 17 1.63e-04 0.528 7.15e-03
Plasma lipoprotein assembly 15 7.08e-04 -0.505 2.03e-02
Interleukin-4 and Interleukin-13 signaling 73 1.79e-13 0.499 1.14e-10
Cristae formation 10 7.29e-03 -0.490 9.68e-02
Cell recruitment (pro-inflammatory response) 17 5.08e-04 0.487 1.62e-02
Purinergic signaling in leishmaniasis infection 17 5.08e-04 0.487 1.62e-02
Activation of Matrix Metalloproteinases 15 2.19e-03 0.457 4.32e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.37e-02 -0.450 1.42e-01
The NLRP3 inflammasome 13 6.06e-03 0.440 8.30e-02
Interleukin-10 signaling 19 9.14e-04 0.439 2.48e-02
Diseases associated with the TLR signaling cascade 19 1.14e-03 0.431 2.68e-02
Diseases of Immune System 19 1.14e-03 0.431 2.68e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 1.85e-02 0.430 1.60e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.00e-03 0.425 2.58e-02
Defective B4GALT7 causes EDS, progeroid type 15 4.80e-03 0.421 7.11e-02
Interleukin-37 signaling 17 2.92e-03 0.417 5.09e-02
PCNA-Dependent Long Patch Base Excision Repair 19 2.02e-03 -0.409 4.22e-02
Translesion synthesis by REV1 14 8.16e-03 -0.408 1.04e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17 4.85e-03 0.395 7.11e-02
Synthesis of IP2, IP, and Ins in the cytosol 12 1.84e-02 0.393 1.60e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 1.48e-02 -0.391 1.45e-01
FCGR activation 10 3.25e-02 0.390 2.31e-01
Post-chaperonin tubulin folding pathway 15 9.29e-03 0.388 1.13e-01
Adenylate cyclase inhibitory pathway 12 2.19e-02 0.382 1.80e-01
Translesion synthesis by POLI 15 1.07e-02 -0.381 1.24e-01
Mitochondrial tRNA aminoacylation 18 5.28e-03 -0.380 7.56e-02
Defective B3GAT3 causes JDSSDHD 15 1.09e-02 0.380 1.25e-01
Cell-extracellular matrix interactions 15 1.10e-02 0.379 1.25e-01
Regulation of Complement cascade 24 1.30e-03 0.379 2.90e-02
Removal of the Flap Intermediate from the C-strand 16 8.66e-03 -0.379 1.08e-01
Striated Muscle Contraction 31 2.67e-04 -0.378 1.00e-02
Complement cascade 27 7.18e-04 0.376 2.03e-02
Interleukin-15 signaling 13 2.07e-02 0.371 1.73e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 15 1.37e-02 0.368 1.42e-01
Mitochondrial calcium ion transport 21 3.74e-03 -0.366 5.89e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 22 3.30e-03 -0.362 5.46e-02
Processing of SMDT1 15 1.58e-02 -0.360 1.49e-01
Mitochondrial protein import 56 3.49e-06 -0.359 4.05e-04
tRNA processing in the mitochondrion 11 4.04e-02 0.357 2.59e-01
Biosynthesis of DHA-derived SPMs 12 3.37e-02 -0.354 2.35e-01
AKT phosphorylates targets in the cytosol 14 2.26e-02 0.352 1.83e-01
Methylation 12 3.54e-02 -0.351 2.41e-01
Interferon alpha/beta signaling 40 1.37e-04 0.349 7.00e-03
Citric acid cycle (TCA cycle) 22 4.86e-03 -0.347 7.11e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 33 6.25e-04 0.344 1.89e-02
Peroxisomal lipid metabolism 24 3.67e-03 -0.343 5.84e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Initial triggering of complement 12 1.09e-05 7.33e-01 9.24e-04
Signal regulatory protein family interactions 13 1.70e-05 6.89e-01 1.36e-03
Xenobiotics 14 1.94e-05 -6.59e-01 1.45e-03
Chemokine receptors bind chemokines 16 2.48e-04 5.29e-01 9.91e-03
RIP-mediated NFkB activation via ZBP1 17 1.63e-04 5.28e-01 7.15e-03
Plasma lipoprotein assembly 15 7.08e-04 -5.05e-01 2.03e-02
Interleukin-4 and Interleukin-13 signaling 73 1.79e-13 4.99e-01 1.14e-10
Cristae formation 10 7.29e-03 -4.90e-01 9.68e-02
Cell recruitment (pro-inflammatory response) 17 5.08e-04 4.87e-01 1.62e-02
Purinergic signaling in leishmaniasis infection 17 5.08e-04 4.87e-01 1.62e-02
Activation of Matrix Metalloproteinases 15 2.19e-03 4.57e-01 4.32e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.37e-02 -4.50e-01 1.42e-01
The NLRP3 inflammasome 13 6.06e-03 4.40e-01 8.30e-02
Interleukin-10 signaling 19 9.14e-04 4.39e-01 2.48e-02
Diseases associated with the TLR signaling cascade 19 1.14e-03 4.31e-01 2.68e-02
Diseases of Immune System 19 1.14e-03 4.31e-01 2.68e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 1.85e-02 4.30e-01 1.60e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.00e-03 4.25e-01 2.58e-02
Defective B4GALT7 causes EDS, progeroid type 15 4.80e-03 4.21e-01 7.11e-02
Interleukin-37 signaling 17 2.92e-03 4.17e-01 5.09e-02
PCNA-Dependent Long Patch Base Excision Repair 19 2.02e-03 -4.09e-01 4.22e-02
Translesion synthesis by REV1 14 8.16e-03 -4.08e-01 1.04e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17 4.85e-03 3.95e-01 7.11e-02
Synthesis of IP2, IP, and Ins in the cytosol 12 1.84e-02 3.93e-01 1.60e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 1.48e-02 -3.91e-01 1.45e-01
FCGR activation 10 3.25e-02 3.90e-01 2.31e-01
Post-chaperonin tubulin folding pathway 15 9.29e-03 3.88e-01 1.13e-01
Adenylate cyclase inhibitory pathway 12 2.19e-02 3.82e-01 1.80e-01
Translesion synthesis by POLI 15 1.07e-02 -3.81e-01 1.24e-01
Mitochondrial tRNA aminoacylation 18 5.28e-03 -3.80e-01 7.56e-02
Defective B3GAT3 causes JDSSDHD 15 1.09e-02 3.80e-01 1.25e-01
Cell-extracellular matrix interactions 15 1.10e-02 3.79e-01 1.25e-01
Regulation of Complement cascade 24 1.30e-03 3.79e-01 2.90e-02
Removal of the Flap Intermediate from the C-strand 16 8.66e-03 -3.79e-01 1.08e-01
Striated Muscle Contraction 31 2.67e-04 -3.78e-01 1.00e-02
Complement cascade 27 7.18e-04 3.76e-01 2.03e-02
Interleukin-15 signaling 13 2.07e-02 3.71e-01 1.73e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 15 1.37e-02 3.68e-01 1.42e-01
Mitochondrial calcium ion transport 21 3.74e-03 -3.66e-01 5.89e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 22 3.30e-03 -3.62e-01 5.46e-02
Processing of SMDT1 15 1.58e-02 -3.60e-01 1.49e-01
Mitochondrial protein import 56 3.49e-06 -3.59e-01 4.05e-04
tRNA processing in the mitochondrion 11 4.04e-02 3.57e-01 2.59e-01
Biosynthesis of DHA-derived SPMs 12 3.37e-02 -3.54e-01 2.35e-01
AKT phosphorylates targets in the cytosol 14 2.26e-02 3.52e-01 1.83e-01
Methylation 12 3.54e-02 -3.51e-01 2.41e-01
Interferon alpha/beta signaling 40 1.37e-04 3.49e-01 7.00e-03
Citric acid cycle (TCA cycle) 22 4.86e-03 -3.47e-01 7.11e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 33 6.25e-04 3.44e-01 1.89e-02
Peroxisomal lipid metabolism 24 3.67e-03 -3.43e-01 5.84e-02
Dissolution of Fibrin Clot 10 6.12e-02 3.42e-01 3.22e-01
Mismatch Repair 14 2.70e-02 -3.41e-01 2.05e-01
PECAM1 interactions 10 6.18e-02 3.41e-01 3.24e-01
Zinc transporters 12 4.09e-02 3.41e-01 2.59e-01
Glyoxylate metabolism and glycine degradation 24 4.01e-03 -3.39e-01 6.15e-02
TRAF6 mediated NF-kB activation 21 7.14e-03 3.39e-01 9.57e-02
Regulation of IFNA signaling 12 4.26e-02 3.38e-01 2.66e-01
Translesion synthesis by POLK 15 2.57e-02 -3.33e-01 2.00e-01
Regulation of KIT signaling 15 2.58e-02 3.32e-01 2.00e-01
Processive synthesis on the C-strand of the telomere 18 1.49e-02 -3.32e-01 1.45e-01
Activated NTRK2 signals through FRS2 and FRS3 10 7.01e-02 3.31e-01 3.39e-01
SUMOylation of immune response proteins 11 5.82e-02 3.30e-01 3.18e-01
Cleavage of the damaged purine 10 7.10e-02 -3.30e-01 3.39e-01
Depurination 10 7.10e-02 -3.30e-01 3.39e-01
Recognition and association of DNA glycosylase with site containing an affected purine 10 7.10e-02 -3.30e-01 3.39e-01
The role of Nef in HIV-1 replication and disease pathogenesis 22 7.97e-03 3.27e-01 1.04e-01
Formation of tubulin folding intermediates by CCT/TriC 17 2.00e-02 3.26e-01 1.70e-01
Cytosolic iron-sulfur cluster assembly 10 7.46e-02 3.26e-01 3.45e-01
A tetrasaccharide linker sequence is required for GAG synthesis 19 1.41e-02 3.25e-01 1.44e-01
Assembly of collagen fibrils and other multimeric structures 46 1.55e-04 3.23e-01 7.04e-03
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 24 6.72e-03 3.20e-01 9.10e-02
Metal ion SLC transporters 20 1.43e-02 3.17e-01 1.44e-01
Prolactin receptor signaling 10 8.61e-02 -3.13e-01 3.72e-01
HS-GAG degradation 18 2.19e-02 3.12e-01 1.80e-01
Class I peroxisomal membrane protein import 20 1.59e-02 -3.12e-01 1.49e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 5.28e-02 -3.10e-01 3.00e-01
Biosynthesis of specialized proresolving mediators (SPMs) 14 4.46e-02 -3.10e-01 2.72e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 6.31e-02 3.10e-01 3.25e-01
Defective EXT2 causes exostoses 2 12 6.31e-02 3.10e-01 3.25e-01
MET activates PTK2 signaling 15 3.88e-02 3.08e-01 2.56e-01
HS-GAG biosynthesis 21 1.48e-02 3.07e-01 1.45e-01
Translesion Synthesis by POLH 16 3.38e-02 -3.07e-01 2.35e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 12 6.61e-02 3.06e-01 3.31e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 12 6.61e-02 3.06e-01 3.31e-01
Heparan sulfate/heparin (HS-GAG) metabolism 38 1.23e-03 3.03e-01 2.80e-02
Complex I biogenesis 53 1.54e-04 -3.01e-01 7.04e-03
Meiotic recombination 17 3.23e-02 -3.00e-01 2.31e-01
Peptide ligand-binding receptors 50 2.57e-04 2.99e-01 9.91e-03
Attenuation phase 20 2.07e-02 2.99e-01 1.73e-01
Gluconeogenesis 27 7.51e-03 -2.97e-01 9.87e-02
Mitochondrial translation elongation 83 4.02e-06 -2.93e-01 4.26e-04
Gastrin-CREB signalling pathway via PKC and MAPK 16 4.32e-02 2.92e-01 2.69e-01
O-linked glycosylation of mucins 25 1.16e-02 2.92e-01 1.26e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 11 9.42e-02 -2.92e-01 3.93e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 22 1.86e-02 -2.90e-01 1.60e-01
Transcriptional regulation of granulopoiesis 27 9.67e-03 2.88e-01 1.16e-01
Mitochondrial translation 89 2.96e-06 -2.87e-01 3.77e-04
Glycogen storage diseases 12 8.57e-02 -2.87e-01 3.71e-01
Collagen formation 69 4.24e-05 2.85e-01 2.46e-03
rRNA processing in the mitochondrion 12 8.76e-02 2.85e-01 3.76e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 5.03e-02 2.83e-01 2.87e-01
Mitochondrial translation termination 83 8.91e-06 -2.82e-01 8.73e-04
Mitochondrial translation initiation 83 1.00e-05 -2.81e-01 9.14e-04
MET promotes cell motility 25 1.51e-02 2.81e-01 1.45e-01
Ephrin signaling 17 4.59e-02 2.80e-01 2.76e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 15 6.11e-02 2.79e-01 3.22e-01
Miscellaneous transport and binding events 17 4.77e-02 2.78e-01 2.76e-01
Interleukin-20 family signaling 13 8.34e-02 2.77e-01 3.65e-01
Interleukin-6 signaling 10 1.33e-01 2.75e-01 4.54e-01
The canonical retinoid cycle in rods (twilight vision) 11 1.16e-01 -2.74e-01 4.28e-01
Class A/1 (Rhodopsin-like receptors) 75 4.31e-05 2.73e-01 2.46e-03
p75NTR signals via NF-kB 14 7.72e-02 2.73e-01 3.49e-01
Chondroitin sulfate biosynthesis 14 7.76e-02 2.73e-01 3.49e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 1.36e-01 -2.72e-01 4.59e-01
Diseases associated with glycosylation precursor biosynthesis 18 4.67e-02 -2.71e-01 2.76e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 11 1.22e-01 2.70e-01 4.38e-01
HIV Transcription Initiation 43 2.30e-03 -2.69e-01 4.32e-02
RNA Polymerase II HIV Promoter Escape 43 2.30e-03 -2.69e-01 4.32e-02
RNA Polymerase II Promoter Escape 43 2.30e-03 -2.69e-01 4.32e-02
RNA Polymerase II Transcription Initiation 43 2.30e-03 -2.69e-01 4.32e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 2.30e-03 -2.69e-01 4.32e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 2.30e-03 -2.69e-01 4.32e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 12 1.07e-01 -2.69e-01 4.10e-01
Telomere C-strand (Lagging Strand) Synthesis 30 1.12e-02 -2.68e-01 1.26e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 1.11e-01 2.66e-01 4.17e-01
Glutamate and glutamine metabolism 10 1.46e-01 2.65e-01 4.75e-01
ROS and RNS production in phagocytes 26 1.97e-02 2.64e-01 1.68e-01
HSF1-dependent transactivation 30 1.23e-02 2.64e-01 1.33e-01
DCC mediated attractive signaling 13 9.95e-02 2.64e-01 4.01e-01
Interleukin-7 signaling 16 6.79e-02 2.64e-01 3.37e-01
Processing of Intronless Pre-mRNAs 17 6.11e-02 2.62e-01 3.22e-01
Scavenging of heme from plasma 10 1.52e-01 -2.61e-01 4.84e-01
FOXO-mediated transcription of cell cycle genes 16 7.10e-02 2.61e-01 3.39e-01
tRNA Aminoacylation 24 2.74e-02 -2.60e-01 2.07e-01
Signaling by NTRK2 (TRKB) 21 3.93e-02 2.60e-01 2.58e-01
Protein localization 139 1.36e-07 -2.60e-01 2.47e-05
Amino acid transport across the plasma membrane 20 4.60e-02 2.58e-01 2.76e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 4.71e-02 2.57e-01 2.76e-01
Extra-nuclear estrogen signaling 60 6.05e-04 2.56e-01 1.88e-02
Respiratory electron transport 92 2.46e-05 -2.55e-01 1.74e-03
O-linked glycosylation 55 1.11e-03 2.54e-01 2.68e-02
MET activates RAP1 and RAC1 10 1.65e-01 2.54e-01 5.06e-01
IRE1alpha activates chaperones 47 2.67e-03 2.53e-01 4.79e-02
Constitutive Signaling by AKT1 E17K in Cancer 26 2.57e-02 2.53e-01 2.00e-01
CASP8 activity is inhibited 10 1.68e-01 -2.52e-01 5.08e-01
Dimerization of procaspase-8 10 1.68e-01 -2.52e-01 5.08e-01
Regulation by c-FLIP 10 1.68e-01 -2.52e-01 5.08e-01
Assembly of active LPL and LIPC lipase complexes 12 1.32e-01 2.51e-01 4.53e-01
Constitutive Signaling by Overexpressed ERBB2 10 1.70e-01 2.51e-01 5.09e-01
Phase 2 - plateau phase 11 1.50e-01 -2.51e-01 4.81e-01
Cytochrome P450 - arranged by substrate type 31 1.61e-02 -2.50e-01 1.49e-01
Regulation of beta-cell development 18 6.75e-02 2.49e-01 3.36e-01
Nicotinamide salvaging 12 1.36e-01 2.49e-01 4.59e-01
Chaperone Mediated Autophagy 15 9.71e-02 2.48e-01 3.98e-01
Metabolism of Angiotensinogen to Angiotensins 12 1.38e-01 2.47e-01 4.60e-01
Regulation of localization of FOXO transcription factors 12 1.40e-01 2.46e-01 4.66e-01
Degradation of the extracellular matrix 65 6.85e-04 2.44e-01 2.03e-02
Polymerase switching on the C-strand of the telomere 23 4.41e-02 -2.43e-01 2.70e-01
Regulation of TP53 Activity through Association with Co-factors 12 1.46e-01 2.42e-01 4.75e-01
Translation of structural proteins 26 3.27e-02 2.42e-01 2.31e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.17e-01 2.42e-01 4.28e-01
Transport of bile salts and organic acids, metal ions and amine compounds 39 9.01e-03 2.42e-01 1.12e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 96 4.45e-05 -2.42e-01 2.46e-03
Other interleukin signaling 16 9.46e-02 2.41e-01 3.94e-01
Inflammasomes 16 9.49e-02 2.41e-01 3.94e-01
Unwinding of DNA 11 1.67e-01 2.41e-01 5.08e-01
RHO GTPases Activate WASPs and WAVEs 34 1.52e-02 2.41e-01 1.45e-01
Collagen biosynthesis and modifying enzymes 50 3.28e-03 2.41e-01 5.46e-02
The citric acid (TCA) cycle and respiratory electron transport 142 8.15e-07 -2.40e-01 1.15e-04
Termination of translesion DNA synthesis 27 3.17e-02 -2.39e-01 2.31e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 1.91e-01 2.39e-01 5.40e-01
alpha-linolenic acid (ALA) metabolism 10 1.91e-01 2.39e-01 5.40e-01
Lagging Strand Synthesis 19 7.24e-02 -2.38e-01 3.41e-01
Recognition of DNA damage by PCNA-containing replication complex 25 4.06e-02 -2.37e-01 2.59e-01
Laminin interactions 21 6.13e-02 2.36e-01 3.22e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 50 3.99e-03 -2.36e-01 6.15e-02
IKK complex recruitment mediated by RIP1 17 9.35e-02 2.35e-01 3.92e-01
Dual Incision in GG-NER 38 1.24e-02 -2.35e-01 1.33e-01
Diseases of programmed cell death 19 7.74e-02 2.34e-01 3.49e-01
CS/DS degradation 10 2.01e-01 2.33e-01 5.57e-01
Diseases associated with O-glycosylation of proteins 34 1.86e-02 2.33e-01 1.60e-01
NF-kB is activated and signals survival 11 1.84e-01 2.31e-01 5.30e-01
Base Excision Repair 41 1.05e-02 -2.31e-01 1.23e-01
Regulation of necroptotic cell death 12 1.66e-01 -2.31e-01 5.07e-01
RUNX3 regulates NOTCH signaling 13 1.49e-01 2.31e-01 4.80e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 1.10e-01 2.31e-01 4.17e-01
Signaling by ERBB2 TMD/JMD mutants 15 1.22e-01 2.31e-01 4.38e-01
Peroxisomal protein import 51 4.50e-03 -2.30e-01 6.83e-02
Unfolded Protein Response (UPR) 82 3.26e-04 2.30e-01 1.15e-02
TICAM1, RIP1-mediated IKK complex recruitment 16 1.12e-01 2.29e-01 4.17e-01
Phase 0 - rapid depolarisation 22 6.32e-02 -2.29e-01 3.25e-01
RHO GTPases activate PAKs 20 7.79e-02 -2.28e-01 3.49e-01
XBP1(S) activates chaperone genes 45 8.31e-03 2.28e-01 1.05e-01
RHO GTPases activate IQGAPs 10 2.15e-01 2.26e-01 5.75e-01
N-glycan antennae elongation in the medial/trans-Golgi 18 9.69e-02 2.26e-01 3.98e-01
Dual incision in TC-NER 60 2.48e-03 -2.26e-01 4.51e-02
Maturation of nucleoprotein 10 2.16e-01 2.26e-01 5.76e-01
Keratinization 15 1.31e-01 2.25e-01 4.50e-01
Phase I - Functionalization of compounds 61 2.36e-03 -2.25e-01 4.36e-02
Regulation of TLR by endogenous ligand 12 1.77e-01 -2.25e-01 5.18e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 12 1.77e-01 2.25e-01 5.18e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 1.53e-02 2.25e-01 1.45e-01
VEGFR2 mediated vascular permeability 26 4.77e-02 2.24e-01 2.76e-01
Signaling by Interleukins 316 9.19e-12 2.24e-01 2.93e-09
Fanconi Anemia Pathway 26 4.82e-02 -2.24e-01 2.77e-01
Glycosaminoglycan metabolism 91 2.56e-04 2.22e-01 9.91e-03
Erythropoietin activates RAS 12 1.85e-01 2.21e-01 5.31e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 18 1.06e-01 2.20e-01 4.08e-01
Neurodegenerative Diseases 18 1.06e-01 2.20e-01 4.08e-01
Regulation of RUNX1 Expression and Activity 17 1.18e-01 2.19e-01 4.28e-01
Ion homeostasis 40 1.67e-02 -2.19e-01 1.51e-01
Leading Strand Synthesis 14 1.57e-01 -2.19e-01 4.91e-01
Polymerase switching 14 1.57e-01 -2.19e-01 4.91e-01
SHC1 events in EGFR signaling 10 2.32e-01 2.18e-01 5.99e-01
Sema3A PAK dependent Axon repulsion 15 1.44e-01 2.18e-01 4.70e-01
Signaling by Leptin 11 2.12e-01 2.18e-01 5.73e-01
GRB2 events in ERBB2 signaling 10 2.34e-01 2.17e-01 6.01e-01
O-glycosylation of TSR domain-containing proteins 25 6.06e-02 2.17e-01 3.22e-01
Antigen processing-Cross presentation 78 1.03e-03 2.15e-01 2.58e-02
PI3K/AKT Signaling in Cancer 70 1.90e-03 2.15e-01 4.05e-02
Signaling by Retinoic Acid 32 3.55e-02 -2.15e-01 2.41e-01
Cell surface interactions at the vascular wall 90 4.45e-04 2.15e-01 1.52e-02
Transcription of the HIV genome 62 3.67e-03 -2.14e-01 5.84e-02
Other semaphorin interactions 17 1.28e-01 2.13e-01 4.46e-01
Scavenging by Class A Receptors 15 1.56e-01 2.12e-01 4.89e-01
Extension of Telomeres 43 1.64e-02 -2.12e-01 1.50e-01
KSRP (KHSRP) binds and destabilizes mRNA 16 1.44e-01 2.11e-01 4.70e-01
Mitochondrial Fatty Acid Beta-Oxidation 31 4.25e-02 -2.11e-01 2.66e-01
Collagen degradation 24 7.54e-02 2.10e-01 3.47e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 59 5.74e-03 -2.08e-01 8.04e-02
Mitochondrial biogenesis 67 3.29e-03 -2.08e-01 5.46e-02
NOTCH3 Intracellular Domain Regulates Transcription 19 1.18e-01 2.07e-01 4.28e-01
Glycogen synthesis 12 2.14e-01 -2.07e-01 5.75e-01
Resolution of Abasic Sites (AP sites) 34 3.69e-02 -2.07e-01 2.47e-01
Fatty acyl-CoA biosynthesis 22 9.34e-02 2.07e-01 3.92e-01
SLC transporter disorders 55 8.20e-03 2.06e-01 1.04e-01
Downregulation of ERBB2 signaling 20 1.11e-01 2.06e-01 4.17e-01
Metabolism of cofactors 18 1.31e-01 -2.06e-01 4.50e-01
Phase II - Conjugation of compounds 60 5.90e-03 -2.06e-01 8.17e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 2.40e-01 2.05e-01 6.04e-01
PERK regulates gene expression 28 6.32e-02 2.03e-01 3.25e-01
Export of Viral Ribonucleoproteins from Nucleus 27 6.83e-02 2.03e-01 3.37e-01
HSF1 activation 22 9.99e-02 2.03e-01 4.01e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 73 2.79e-03 -2.03e-01 4.94e-02
Transcription of E2F targets under negative control by DREAM complex 17 1.48e-01 2.03e-01 4.79e-01
GPVI-mediated activation cascade 28 6.60e-02 2.01e-01 3.31e-01
Transcriptional regulation by RUNX3 87 1.23e-03 2.01e-01 2.80e-02
CTLA4 inhibitory signaling 18 1.41e-01 2.01e-01 4.66e-01
Extracellular matrix organization 213 5.19e-07 2.00e-01 8.27e-05
Defective B3GALTL causes Peters-plus syndrome (PpS) 24 9.00e-02 2.00e-01 3.80e-01
Leishmania infection 147 3.09e-05 2.00e-01 1.97e-03
Telomere Extension By Telomerase 19 1.33e-01 -1.99e-01 4.54e-01
Glycogen metabolism 23 9.87e-02 -1.99e-01 4.01e-01
Lysosome Vesicle Biogenesis 28 6.92e-02 1.99e-01 3.39e-01
Formation of the Early Elongation Complex 31 5.63e-02 -1.98e-01 3.11e-01
Formation of the HIV-1 Early Elongation Complex 31 5.63e-02 -1.98e-01 3.11e-01
Interactions of Rev with host cellular proteins 30 6.07e-02 1.98e-01 3.22e-01
ATF6 (ATF6-alpha) activates chaperones 12 2.36e-01 1.98e-01 6.02e-01
Neutrophil degranulation 341 4.44e-10 1.98e-01 1.13e-07
Signaling by SCF-KIT 39 3.28e-02 1.98e-01 2.31e-01
FCGR3A-mediated phagocytosis 55 1.16e-02 1.97e-01 1.26e-01
Leishmania phagocytosis 55 1.16e-02 1.97e-01 1.26e-01
Parasite infection 55 1.16e-02 1.97e-01 1.26e-01
Basigin interactions 19 1.38e-01 1.97e-01 4.60e-01
G0 and Early G1 20 1.29e-01 1.96e-01 4.48e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 10 2.84e-01 1.96e-01 6.47e-01
RA biosynthesis pathway 13 2.25e-01 -1.94e-01 5.88e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 29 7.03e-02 1.94e-01 3.39e-01
FCGR3A-mediated IL10 synthesis 33 5.41e-02 1.94e-01 3.03e-01
Rev-mediated nuclear export of HIV RNA 29 7.10e-02 1.94e-01 3.39e-01
Sulfur amino acid metabolism 23 1.08e-01 -1.94e-01 4.13e-01
Negative regulation of the PI3K/AKT network 76 3.59e-03 1.93e-01 5.84e-02
Intra-Golgi traffic 40 3.48e-02 1.93e-01 2.41e-01
Biological oxidations 125 2.01e-04 -1.93e-01 8.54e-03
NGF-stimulated transcription 32 5.91e-02 1.93e-01 3.20e-01
Constitutive Signaling by Aberrant PI3K in Cancer 43 2.90e-02 1.93e-01 2.14e-01
RUNX2 regulates bone development 25 9.61e-02 1.92e-01 3.97e-01
AKT phosphorylates targets in the nucleus 10 2.93e-01 1.92e-01 6.56e-01
Muscle contraction 132 1.45e-04 -1.92e-01 7.04e-03
ATF4 activates genes in response to endoplasmic reticulum stress 24 1.06e-01 1.91e-01 4.08e-01
Nuclear Pore Complex (NPC) Disassembly 27 8.72e-02 1.90e-01 3.75e-01
Degradation of cysteine and homocysteine 13 2.35e-01 -1.90e-01 6.02e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 14 2.19e-01 1.90e-01 5.78e-01
Bile acid and bile salt metabolism 22 1.24e-01 -1.90e-01 4.38e-01
Recycling pathway of L1 23 1.17e-01 1.89e-01 4.28e-01
Regulation of actin dynamics for phagocytic cup formation 57 1.40e-02 1.88e-01 1.43e-01
Pre-NOTCH Transcription and Translation 32 6.53e-02 1.88e-01 3.31e-01
EPHB-mediated forward signaling 32 6.56e-02 1.88e-01 3.31e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 15 2.07e-01 1.88e-01 5.65e-01
Synthesis of very long-chain fatty acyl-CoAs 12 2.59e-01 1.88e-01 6.23e-01
Meiosis 39 4.38e-02 -1.87e-01 2.70e-01
Signaling by FGFR2 IIIa TM 16 1.97e-01 -1.87e-01 5.49e-01
ADP signalling through P2Y purinoceptor 12 14 2.28e-01 1.86e-01 5.93e-01
EPHA-mediated growth cone collapse 14 2.28e-01 -1.86e-01 5.93e-01
Antimicrobial peptides 10 3.09e-01 1.86e-01 6.72e-01
Vpr-mediated nuclear import of PICs 28 8.93e-02 1.86e-01 3.78e-01
Postmitotic nuclear pore complex (NPC) reformation 24 1.16e-01 1.86e-01 4.28e-01
Insulin processing 18 1.75e-01 -1.85e-01 5.15e-01
Formation of TC-NER Pre-Incision Complex 49 2.55e-02 -1.85e-01 2.00e-01
Retrograde neurotrophin signalling 12 2.69e-01 1.84e-01 6.32e-01
Activation of GABAB receptors 26 1.04e-01 1.84e-01 4.08e-01
GABA B receptor activation 26 1.04e-01 1.84e-01 4.08e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 33 6.71e-02 -1.84e-01 3.35e-01
p75NTR recruits signalling complexes 11 2.91e-01 1.84e-01 6.56e-01
RNA Pol II CTD phosphorylation and interaction with CE 25 1.12e-01 -1.84e-01 4.17e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 25 1.12e-01 -1.84e-01 4.17e-01
Signaling by Non-Receptor Tyrosine Kinases 42 4.04e-02 1.83e-01 2.59e-01
Signaling by PTK6 42 4.04e-02 1.83e-01 2.59e-01
Carboxyterminal post-translational modifications of tubulin 23 1.29e-01 1.83e-01 4.48e-01
SUMOylation of DNA replication proteins 36 5.83e-02 1.82e-01 3.18e-01
mRNA Capping 27 1.02e-01 -1.82e-01 4.06e-01
Synthesis of PC 22 1.42e-01 -1.81e-01 4.69e-01
Synthesis of bile acids and bile salts 19 1.74e-01 -1.80e-01 5.15e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 69 9.84e-03 1.80e-01 1.17e-01
FGFR2 mutant receptor activation 19 1.75e-01 -1.80e-01 5.15e-01
Diseases associated with glycosaminoglycan metabolism 34 7.20e-02 1.78e-01 3.41e-01
Synthesis, secretion, and deacylation of Ghrelin 12 2.88e-01 -1.77e-01 6.52e-01
HDMs demethylate histones 21 1.61e-01 1.77e-01 5.00e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.98e-01 -1.75e-01 5.50e-01
Glycogen breakdown (glycogenolysis) 14 2.56e-01 -1.75e-01 6.22e-01
NEP/NS2 Interacts with the Cellular Export Machinery 26 1.23e-01 1.75e-01 4.38e-01
Elastic fibre formation 35 7.43e-02 1.74e-01 3.45e-01
Interleukin-1 family signaling 109 1.72e-03 1.74e-01 3.78e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 3.44e-01 1.73e-01 7.12e-01
Telomere Maintenance 56 2.67e-02 -1.71e-01 2.04e-01
Glutathione synthesis and recycling 10 3.49e-01 1.71e-01 7.14e-01
SUMOylation of SUMOylation proteins 28 1.17e-01 1.71e-01 4.28e-01
Cleavage of the damaged pyrimidine 14 2.69e-01 -1.71e-01 6.32e-01
Depyrimidination 14 2.69e-01 -1.71e-01 6.32e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 2.69e-01 -1.71e-01 6.32e-01
FRS-mediated FGFR3 signaling 12 3.08e-01 1.70e-01 6.72e-01
Nuclear import of Rev protein 27 1.27e-01 1.70e-01 4.43e-01
Cytokine Signaling in Immune system 589 3.40e-12 1.70e-01 1.44e-09
Nonhomologous End-Joining (NHEJ) 31 1.02e-01 -1.70e-01 4.06e-01
Signal transduction by L1 21 1.78e-01 1.70e-01 5.19e-01
Inhibition of DNA recombination at telomere 19 2.02e-01 -1.69e-01 5.57e-01
Interferon Signaling 134 7.62e-04 1.69e-01 2.11e-02
Glutathione conjugation 28 1.22e-01 -1.69e-01 4.38e-01
Prostacyclin signalling through prostacyclin receptor 13 2.93e-01 1.69e-01 6.56e-01
HDR through Single Strand Annealing (SSA) 31 1.05e-01 -1.68e-01 4.08e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 21 1.83e-01 -1.68e-01 5.30e-01
Metalloprotease DUBs 15 2.62e-01 -1.67e-01 6.25e-01
mRNA Splicing - Minor Pathway 47 4.74e-02 -1.67e-01 2.76e-01
Voltage gated Potassium channels 16 2.47e-01 1.67e-01 6.12e-01
Nucleobase biosynthesis 15 2.62e-01 1.67e-01 6.25e-01
Mucopolysaccharidoses 11 3.40e-01 1.66e-01 7.07e-01
Acyl chain remodelling of PS 12 3.21e-01 1.66e-01 6.84e-01
eNOS activation 11 3.42e-01 1.66e-01 7.09e-01
Nephrin family interactions 19 2.13e-01 -1.65e-01 5.74e-01
Regulation of TP53 Activity through Phosphorylation 76 1.29e-02 -1.65e-01 1.37e-01
Signaling by PDGFR in disease 20 2.02e-01 1.65e-01 5.57e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 24 1.63e-01 -1.65e-01 5.03e-01
Interferon gamma signaling 55 3.52e-02 1.64e-01 2.41e-01
Hyaluronan uptake and degradation 10 3.69e-01 1.64e-01 7.32e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 58 3.18e-02 1.63e-01 2.31e-01
Intrinsic Pathway of Fibrin Clot Formation 10 3.73e-01 -1.63e-01 7.36e-01
Reproduction 45 5.93e-02 -1.63e-01 3.20e-01
Transport of Ribonucleoproteins into the Host Nucleus 26 1.54e-01 1.62e-01 4.87e-01
Peptide chain elongation 47 5.58e-02 1.61e-01 3.10e-01
Anti-inflammatory response favouring Leishmania parasite infection 76 1.51e-02 1.61e-01 1.45e-01
Leishmania parasite growth and survival 76 1.51e-02 1.61e-01 1.45e-01
Interconversion of nucleotide di- and triphosphates 22 1.91e-01 1.61e-01 5.40e-01
Nitric oxide stimulates guanylate cyclase 15 2.81e-01 1.61e-01 6.46e-01
PKA activation in glucagon signalling 15 2.83e-01 1.60e-01 6.47e-01
Formation of HIV elongation complex in the absence of HIV Tat 39 8.41e-02 -1.60e-01 3.67e-01
Collagen chain trimerization 34 1.07e-01 1.60e-01 4.10e-01
Detoxification of Reactive Oxygen Species 29 1.38e-01 1.59e-01 4.60e-01
Growth hormone receptor signaling 18 2.43e-01 1.59e-01 6.09e-01
GAB1 signalosome 13 3.24e-01 1.58e-01 6.86e-01
PKA-mediated phosphorylation of CREB 18 2.46e-01 1.58e-01 6.10e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 21 2.11e-01 1.58e-01 5.72e-01
Signaling by NOTCH2 25 1.73e-01 1.58e-01 5.14e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 33 1.19e-01 1.57e-01 4.29e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.05e-01 1.56e-01 4.08e-01
Base-Excision Repair, AP Site Formation 16 2.80e-01 -1.56e-01 6.45e-01
EGFR downregulation 23 1.97e-01 1.55e-01 5.50e-01
Synthesis of PE 11 3.77e-01 -1.54e-01 7.37e-01
Frs2-mediated activation 11 3.77e-01 1.54e-01 7.37e-01
COPI-independent Golgi-to-ER retrograde traffic 27 1.67e-01 -1.54e-01 5.08e-01
DAP12 interactions 23 2.05e-01 1.53e-01 5.61e-01
IL-6-type cytokine receptor ligand interactions 11 3.81e-01 -1.53e-01 7.41e-01
Non-integrin membrane-ECM interactions 39 9.97e-02 1.52e-01 4.01e-01
Potential therapeutics for SARS 34 1.26e-01 1.52e-01 4.43e-01
ER-Phagosome pathway 64 3.62e-02 1.52e-01 2.44e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 3.64e-01 1.51e-01 7.32e-01
RNA Polymerase II Pre-transcription Events 72 2.68e-02 -1.51e-01 2.04e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 37 1.13e-01 -1.51e-01 4.17e-01
HIV Transcription Elongation 37 1.13e-01 -1.51e-01 4.17e-01
Tat-mediated elongation of the HIV-1 transcript 37 1.13e-01 -1.51e-01 4.17e-01
Inactivation, recovery and regulation of the phototransduction cascade 12 3.66e-01 -1.51e-01 7.32e-01
The phototransduction cascade 12 3.66e-01 -1.51e-01 7.32e-01
Semaphorin interactions 58 4.76e-02 1.51e-01 2.76e-01
ESR-mediated signaling 131 3.00e-03 1.51e-01 5.16e-02
Defects in cobalamin (B12) metabolism 10 4.10e-01 -1.50e-01 7.75e-01
Signaling by PDGF 49 6.88e-02 1.50e-01 3.38e-01
Signaling by NOTCH3 40 1.01e-01 1.50e-01 4.03e-01
Pyruvate metabolism 26 1.86e-01 -1.50e-01 5.31e-01
FGFR1 mutant receptor activation 25 1.95e-01 -1.50e-01 5.46e-01
G beta:gamma signalling through PI3Kgamma 19 2.59e-01 1.50e-01 6.23e-01
Nucleotide Excision Repair 103 9.12e-03 -1.49e-01 1.12e-01
Global Genome Nucleotide Excision Repair (GG-NER) 79 2.26e-02 -1.49e-01 1.83e-01
Telomere C-strand synthesis initiation 12 3.75e-01 -1.48e-01 7.37e-01
Platelet sensitization by LDL 15 3.23e-01 1.48e-01 6.85e-01
Ovarian tumor domain proteases 32 1.50e-01 1.47e-01 4.81e-01
GPCR ligand binding 120 5.53e-03 1.47e-01 7.83e-02
Signaling by Erythropoietin 23 2.23e-01 1.47e-01 5.87e-01
Immune System 1389 5.98e-19 1.47e-01 7.62e-16
Branched-chain amino acid catabolism 20 2.57e-01 -1.46e-01 6.22e-01
Interactions of Vpr with host cellular proteins 30 1.66e-01 1.46e-01 5.08e-01
Fcgamma receptor (FCGR) dependent phagocytosis 80 2.52e-02 1.45e-01 1.99e-01
NS1 Mediated Effects on Host Pathways 31 1.65e-01 1.44e-01 5.06e-01
Hyaluronan metabolism 13 3.74e-01 1.42e-01 7.37e-01
Signaling by EGFR 42 1.11e-01 1.42e-01 4.17e-01
Cardiac conduction 72 3.74e-02 -1.42e-01 2.49e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 37 1.35e-01 1.42e-01 4.59e-01
Aggrephagy 17 3.13e-01 -1.41e-01 6.74e-01
Signaling by BMP 23 2.41e-01 1.41e-01 6.04e-01
Activation of AMPK downstream of NMDARs 10 4.40e-01 -1.41e-01 7.93e-01
Reduction of cytosolic Ca++ levels 10 4.40e-01 -1.41e-01 7.93e-01
Signal amplification 24 2.33e-01 1.41e-01 6.00e-01
Protein ubiquitination 55 7.27e-02 -1.40e-01 3.41e-01
SUMOylation of ubiquitinylation proteins 32 1.71e-01 1.40e-01 5.11e-01
Keratan sulfate biosynthesis 21 2.70e-01 1.39e-01 6.32e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 26 2.22e-01 -1.38e-01 5.86e-01
G-protein activation 15 3.54e-01 1.38e-01 7.20e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 2.51e-01 1.38e-01 6.19e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 3.39e-01 1.38e-01 7.07e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 3.39e-01 1.38e-01 7.07e-01
Translation 219 4.54e-04 -1.38e-01 1.52e-02
ECM proteoglycans 41 1.27e-01 1.38e-01 4.43e-01
Trafficking of GluR2-containing AMPA receptors 11 4.29e-01 1.38e-01 7.89e-01
Innate Immune System 704 1.00e-09 1.37e-01 2.13e-07
WNT ligand biogenesis and trafficking 12 4.13e-01 -1.37e-01 7.75e-01
Signalling to RAS 17 3.31e-01 1.36e-01 6.96e-01
Transcriptional regulation of white adipocyte differentiation 77 3.94e-02 1.36e-01 2.58e-01
Syndecan interactions 19 3.07e-01 1.35e-01 6.72e-01
Diseases of carbohydrate metabolism 28 2.18e-01 -1.35e-01 5.78e-01
SUMOylation of RNA binding proteins 40 1.43e-01 1.34e-01 4.69e-01
Cell-Cell communication 78 4.15e-02 1.34e-01 2.62e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 57 8.16e-02 1.33e-01 3.61e-01
HDR through Homologous Recombination (HRR) 50 1.04e-01 -1.33e-01 4.08e-01
Transcriptional regulation by RUNX2 97 2.41e-02 1.33e-01 1.92e-01
Chromosome Maintenance 71 5.36e-02 -1.33e-01 3.03e-01
Negative regulation of MET activity 16 3.59e-01 1.33e-01 7.27e-01
E3 ubiquitin ligases ubiquitinate target proteins 38 1.60e-01 -1.32e-01 4.99e-01
Signaling by NODAL 13 4.11e-01 1.32e-01 7.75e-01
Signaling by ERBB2 in Cancer 19 3.21e-01 1.32e-01 6.84e-01
Activation of the AP-1 family of transcription factors 10 4.73e-01 -1.31e-01 8.14e-01
Interleukin-2 family signaling 29 2.24e-01 1.31e-01 5.88e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 12 4.37e-01 1.30e-01 7.90e-01
RHO GTPases Activate ROCKs 19 3.29e-01 -1.29e-01 6.95e-01
RMTs methylate histone arginines 28 2.37e-01 1.29e-01 6.03e-01
Nuclear Envelope (NE) Reassembly 59 8.90e-02 1.28e-01 3.78e-01
trans-Golgi Network Vesicle Budding 64 7.66e-02 1.28e-01 3.49e-01
Golgi Cisternae Pericentriolar Stack Reorganization 10 4.83e-01 1.28e-01 8.17e-01
Regulation of TP53 Expression and Degradation 31 2.19e-01 1.28e-01 5.78e-01
Amyloid fiber formation 36 1.86e-01 1.27e-01 5.31e-01
Nuclear Envelope Breakdown 42 1.54e-01 1.27e-01 4.87e-01
Regulation of innate immune responses to cytosolic DNA 10 4.88e-01 -1.27e-01 8.21e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 2.84e-01 -1.26e-01 6.47e-01
Selenocysteine synthesis 50 1.23e-01 1.26e-01 4.38e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 2.76e-01 1.26e-01 6.40e-01
CD28 co-stimulation 28 2.51e-01 1.25e-01 6.19e-01
Dopamine Neurotransmitter Release Cycle 12 4.52e-01 -1.25e-01 7.99e-01
Synthesis of PA 22 3.09e-01 1.25e-01 6.72e-01
Gap junction trafficking 13 4.35e-01 -1.25e-01 7.90e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 21 3.22e-01 -1.25e-01 6.85e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 37 1.89e-01 1.25e-01 5.38e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 2.45e-01 -1.25e-01 6.10e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 51 1.25e-01 1.24e-01 4.38e-01
Ca-dependent events 32 2.24e-01 1.24e-01 5.88e-01
Transcriptional Regulation by E2F6 30 2.42e-01 -1.23e-01 6.07e-01
Viral mRNA Translation 47 1.44e-01 1.23e-01 4.70e-01
Generation of second messenger molecules 14 4.25e-01 1.23e-01 7.85e-01
Influenza Infection 101 3.29e-02 1.23e-01 2.31e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 10 5.01e-01 -1.23e-01 8.30e-01
Regulation of IFNG signaling 13 4.43e-01 1.23e-01 7.94e-01
Transport of Mature mRNA Derived from an Intronless Transcript 36 2.04e-01 1.23e-01 5.59e-01
BBSome-mediated cargo-targeting to cilium 20 3.43e-01 -1.22e-01 7.11e-01
HIV elongation arrest and recovery 27 2.72e-01 -1.22e-01 6.34e-01
Pausing and recovery of HIV elongation 27 2.72e-01 -1.22e-01 6.34e-01
Processing of DNA double-strand break ends 50 1.36e-01 -1.22e-01 4.59e-01
Cellular response to heat stress 84 5.40e-02 1.22e-01 3.03e-01
Activation of BAD and translocation to mitochondria 14 4.31e-01 1.22e-01 7.89e-01
DARPP-32 events 21 3.35e-01 -1.22e-01 7.04e-01
Interleukin-12 family signaling 40 1.84e-01 1.21e-01 5.30e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.17e-01 -1.21e-01 7.75e-01
Myogenesis 26 2.86e-01 -1.21e-01 6.49e-01
SUMOylation of DNA methylation proteins 16 4.03e-01 1.21e-01 7.75e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 25 2.96e-01 1.21e-01 6.59e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 25 2.96e-01 1.21e-01 6.59e-01
Prolonged ERK activation events 13 4.52e-01 1.20e-01 7.99e-01
CaM pathway 30 2.54e-01 1.20e-01 6.20e-01
Calmodulin induced events 30 2.54e-01 1.20e-01 6.20e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 12 4.70e-01 1.20e-01 8.14e-01
FRS-mediated FGFR1 signaling 13 4.53e-01 1.20e-01 8.00e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 4.37e-01 1.20e-01 7.90e-01
G1/S-Specific Transcription 22 3.31e-01 1.20e-01 6.96e-01
Keratan sulfate/keratin metabolism 26 2.93e-01 1.19e-01 6.56e-01
Eukaryotic Translation Elongation 51 1.41e-01 1.19e-01 4.66e-01
Depolymerisation of the Nuclear Lamina 12 4.75e-01 1.19e-01 8.14e-01
Formation of Incision Complex in GG-NER 40 1.94e-01 -1.19e-01 5.44e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 76 7.47e-02 -1.18e-01 3.45e-01
Resolution of D-Loop Structures 22 3.37e-01 -1.18e-01 7.06e-01
Cyclin E associated events during G1/S transition 73 8.19e-02 1.18e-01 3.61e-01
Mitochondrial iron-sulfur cluster biogenesis 12 4.80e-01 1.18e-01 8.14e-01
Ion transport by P-type ATPases 38 2.10e-01 -1.18e-01 5.70e-01
Cyclin A:Cdk2-associated events at S phase entry 75 7.88e-02 1.18e-01 3.51e-01
TRAF3-dependent IRF activation pathway 13 4.64e-01 -1.17e-01 8.09e-01
Costimulation by the CD28 family 45 1.74e-01 1.17e-01 5.15e-01
Presynaptic phase of homologous DNA pairing and strand exchange 30 2.67e-01 -1.17e-01 6.32e-01
Selenoamino acid metabolism 64 1.06e-01 1.17e-01 4.08e-01
DNA Repair 240 1.91e-03 -1.17e-01 4.05e-02
DNA Double-Strand Break Repair 107 3.79e-02 -1.16e-01 2.52e-01
Tight junction interactions 11 5.04e-01 -1.16e-01 8.33e-01
B-WICH complex positively regulates rRNA expression 31 2.63e-01 1.16e-01 6.27e-01
Homology Directed Repair 80 7.32e-02 -1.16e-01 3.41e-01
Metabolism of steroid hormones 13 4.70e-01 1.16e-01 8.14e-01
Host Interactions of HIV factors 106 4.00e-02 1.16e-01 2.59e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 22 3.48e-01 1.16e-01 7.14e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 3.18e-01 -1.15e-01 6.83e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 4.11e-01 -1.15e-01 7.75e-01
Signaling by NTRKs 117 3.21e-02 1.15e-01 2.31e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 77 8.30e-02 1.14e-01 3.65e-01
Cell junction organization 47 1.76e-01 1.14e-01 5.17e-01
Vitamin B5 (pantothenate) metabolism 15 4.44e-01 1.14e-01 7.94e-01
FOXO-mediated transcription of cell death genes 14 4.60e-01 1.14e-01 8.07e-01
Senescence-Associated Secretory Phenotype (SASP) 44 1.92e-01 1.14e-01 5.40e-01
Binding and Uptake of Ligands by Scavenger Receptors 34 2.52e-01 1.14e-01 6.20e-01
Budding and maturation of HIV virion 23 3.46e-01 -1.13e-01 7.14e-01
SHC-mediated cascade:FGFR3 10 5.35e-01 1.13e-01 8.39e-01
Platelet calcium homeostasis 21 3.70e-01 -1.13e-01 7.32e-01
GABA receptor activation 29 2.94e-01 1.13e-01 6.56e-01
Hemostasis 414 9.49e-05 1.13e-01 5.04e-03
rRNA processing 153 1.71e-02 1.12e-01 1.52e-01
Interleukin-12 signaling 35 2.53e-01 1.12e-01 6.20e-01
Smooth Muscle Contraction 34 2.62e-01 -1.11e-01 6.25e-01
Signaling by FGFR2 in disease 29 3.02e-01 -1.11e-01 6.64e-01
Metabolic disorders of biological oxidation enzymes 18 4.16e-01 -1.11e-01 7.75e-01
SLC-mediated transmembrane transport 133 2.80e-02 1.11e-01 2.10e-01
G beta:gamma signalling through CDC42 14 4.75e-01 -1.10e-01 8.14e-01
DNA Damage Bypass 40 2.28e-01 -1.10e-01 5.93e-01
Formation of the cornified envelope 11 5.28e-01 1.10e-01 8.39e-01
Diseases of glycosylation 101 5.81e-02 1.09e-01 3.18e-01
Activated NOTCH1 Transmits Signal to the Nucleus 25 3.46e-01 1.09e-01 7.14e-01
PINK1-PRKN Mediated Mitophagy 17 4.39e-01 -1.08e-01 7.93e-01
Homologous DNA Pairing and Strand Exchange 31 2.96e-01 -1.08e-01 6.59e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.37e-01 -1.07e-01 8.39e-01
Regulation of RUNX3 expression and activity 47 2.03e-01 1.07e-01 5.59e-01
Signaling by ERBB2 KD Mutants 18 4.31e-01 1.07e-01 7.89e-01
Disorders of transmembrane transporters 115 4.78e-02 1.07e-01 2.76e-01
Factors involved in megakaryocyte development and platelet production 81 9.74e-02 1.07e-01 3.98e-01
Removal of the Flap Intermediate 13 5.06e-01 -1.07e-01 8.34e-01
Calnexin/calreticulin cycle 23 3.77e-01 1.07e-01 7.37e-01
PI-3K cascade:FGFR4 11 5.41e-01 -1.06e-01 8.41e-01
Neurotransmitter receptors and postsynaptic signal transmission 102 6.37e-02 1.06e-01 3.26e-01
Transmission across Chemical Synapses 132 3.56e-02 1.06e-01 2.41e-01
Plasma lipoprotein clearance 27 3.40e-01 -1.06e-01 7.07e-01
RORA activates gene expression 17 4.50e-01 -1.06e-01 7.99e-01
Glutamate Neurotransmitter Release Cycle 12 5.26e-01 1.06e-01 8.39e-01
Pausing and recovery of Tat-mediated HIV elongation 25 3.61e-01 -1.06e-01 7.27e-01
Tat-mediated HIV elongation arrest and recovery 25 3.61e-01 -1.06e-01 7.27e-01
Phosphorylation of the APC/C 17 4.56e-01 -1.05e-01 8.02e-01
Estrogen-dependent gene expression 73 1.23e-01 1.05e-01 4.38e-01
Transcriptional regulation by RUNX1 148 2.87e-02 1.04e-01 2.14e-01
Transcriptional activation of mitochondrial biogenesis 48 2.13e-01 -1.04e-01 5.74e-01
Pre-NOTCH Expression and Processing 47 2.18e-01 1.04e-01 5.78e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 5.51e-01 1.04e-01 8.48e-01
Influenza Viral RNA Transcription and Replication 86 9.71e-02 1.04e-01 3.98e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 17 4.60e-01 -1.03e-01 8.07e-01
SARS-CoV Infections 76 1.20e-01 1.03e-01 4.33e-01
Gene Silencing by RNA 55 1.86e-01 1.03e-01 5.31e-01
TRAF6 mediated IRF7 activation 15 4.93e-01 -1.02e-01 8.24e-01
PKA activation 16 4.79e-01 1.02e-01 8.14e-01
Downregulation of TGF-beta receptor signaling 24 3.87e-01 1.02e-01 7.51e-01
Interleukin-1 signaling 87 1.01e-01 1.02e-01 4.05e-01
RUNX2 regulates osteoblast differentiation 19 4.43e-01 1.02e-01 7.94e-01
VLDLR internalisation and degradation 11 5.60e-01 -1.02e-01 8.49e-01
Synthesis of IP3 and IP4 in the cytosol 21 4.22e-01 1.01e-01 7.81e-01
Regulation of TP53 Degradation 30 3.40e-01 1.01e-01 7.07e-01
SRP-dependent cotranslational protein targeting to membrane 68 1.52e-01 1.01e-01 4.84e-01
Post NMDA receptor activation events 44 2.49e-01 1.01e-01 6.15e-01
Pentose phosphate pathway 13 5.30e-01 1.01e-01 8.39e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 2.06e-01 1.01e-01 5.63e-01
Regulation of TP53 Activity 136 4.39e-02 -1.00e-01 2.70e-01
Cell death signalling via NRAGE, NRIF and NADE 63 1.69e-01 1.00e-01 5.09e-01
Signaling by ERBB2 39 2.80e-01 1.00e-01 6.45e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 24 3.99e-01 9.94e-02 7.72e-01
Interleukin receptor SHC signaling 20 4.43e-01 9.91e-02 7.94e-01
Interaction between L1 and Ankyrins 15 5.07e-01 -9.90e-02 8.34e-01
Toll Like Receptor 4 (TLR4) Cascade 112 7.20e-02 9.86e-02 3.41e-01
EPH-Ephrin signaling 77 1.37e-01 9.82e-02 4.60e-01
TICAM1-dependent activation of IRF3/IRF7 10 5.91e-01 9.82e-02 8.62e-01
Synthesis of substrates in N-glycan biosythesis 54 2.13e-01 -9.81e-02 5.74e-01
Glucagon signaling in metabolic regulation 24 4.08e-01 9.76e-02 7.75e-01
Signaling by Receptor Tyrosine Kinases 391 1.03e-03 9.74e-02 2.58e-02
Response of Mtb to phagocytosis 20 4.51e-01 -9.74e-02 7.99e-01
Mitotic Prophase 70 1.60e-01 9.72e-02 4.99e-01
rRNA processing in the nucleus and cytosol 141 4.77e-02 9.69e-02 2.76e-01
ERKs are inactivated 13 5.46e-01 -9.69e-02 8.44e-01
Signaling by ERBB2 ECD mutants 15 5.17e-01 9.67e-02 8.39e-01
Major pathway of rRNA processing in the nucleolus and cytosol 132 5.57e-02 9.67e-02 3.10e-01
Potassium Channels 41 2.86e-01 9.64e-02 6.49e-01
Neurotransmitter release cycle 24 4.15e-01 9.61e-02 7.75e-01
Transcriptional Regulation by MECP2 43 2.76e-01 -9.61e-02 6.40e-01
Activation of NMDA receptors and postsynaptic events 52 2.31e-01 9.60e-02 5.99e-01
Neuronal System 190 2.31e-02 9.60e-02 1.86e-01
Gap junction trafficking and regulation 15 5.22e-01 -9.55e-02 8.39e-01
G2/M DNA damage checkpoint 50 2.44e-01 -9.53e-02 6.09e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 19 4.72e-01 9.53e-02 8.14e-01
L1CAM interactions 70 1.70e-01 9.50e-02 5.09e-01
CD28 dependent PI3K/Akt signaling 19 4.74e-01 9.50e-02 8.14e-01
EPH-ephrin mediated repulsion of cells 38 3.12e-01 9.48e-02 6.74e-01
Nicotinate metabolism 22 4.43e-01 9.46e-02 7.94e-01
Signaling by KIT in disease 19 4.79e-01 9.39e-02 8.14e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 4.79e-01 9.39e-02 8.14e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 44 2.82e-01 9.39e-02 6.47e-01
Regulation of signaling by CBL 18 4.91e-01 9.39e-02 8.23e-01
Regulation of FOXO transcriptional activity by acetylation 10 6.07e-01 9.39e-02 8.69e-01
Acyl chain remodelling of PE 13 5.58e-01 9.38e-02 8.49e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 5.91e-01 9.37e-02 8.62e-01
APC/C:Cdc20 mediated degradation of Cyclin B 19 4.80e-01 -9.36e-02 8.14e-01
COPI-dependent Golgi-to-ER retrograde traffic 59 2.14e-01 9.36e-02 5.75e-01
Regulation of MECP2 expression and activity 26 4.11e-01 -9.33e-02 7.75e-01
NCAM signaling for neurite out-growth 42 2.97e-01 9.31e-02 6.59e-01
NRAGE signals death through JNK 49 2.61e-01 9.30e-02 6.25e-01
Late Phase of HIV Life Cycle 117 8.46e-02 -9.25e-02 3.68e-01
FRS-mediated FGFR2 signaling 13 5.64e-01 9.24e-02 8.50e-01
G alpha (s) signalling events 67 1.92e-01 9.23e-02 5.40e-01
ADORA2B mediated anti-inflammatory cytokines production 48 2.70e-01 9.22e-02 6.32e-01
Transport of the SLBP Dependant Mature mRNA 30 3.82e-01 9.22e-02 7.44e-01
Cytosolic sulfonation of small molecules 15 5.37e-01 -9.22e-02 8.39e-01
Nuclear Events (kinase and transcription factor activation) 54 2.44e-01 9.17e-02 6.09e-01
Uptake and actions of bacterial toxins 22 4.58e-01 9.14e-02 8.05e-01
Metabolism of nucleotides 80 1.62e-01 9.05e-02 5.03e-01
PRC2 methylates histones and DNA 14 5.59e-01 -9.02e-02 8.49e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 5.23e-01 8.96e-02 8.39e-01
Olfactory Signaling Pathway 11 6.07e-01 -8.95e-02 8.69e-01
Processive synthesis on the lagging strand 14 5.63e-01 -8.93e-02 8.50e-01
Biotin transport and metabolism 11 6.10e-01 -8.88e-02 8.73e-01
Signaling by TGFB family members 87 1.53e-01 8.88e-02 4.85e-01
Signaling by MET 55 2.56e-01 8.87e-02 6.22e-01
p75 NTR receptor-mediated signalling 80 1.71e-01 8.86e-02 5.11e-01
RNA Polymerase III Transcription Termination 22 4.72e-01 -8.86e-02 8.14e-01
PIP3 activates AKT signaling 221 2.39e-02 8.85e-02 1.92e-01
Transport of the SLBP independent Mature mRNA 29 4.11e-01 8.83e-02 7.75e-01
Eukaryotic Translation Termination 49 2.86e-01 8.82e-02 6.49e-01
p38MAPK events 12 5.98e-01 8.79e-02 8.65e-01
Cross-presentation of soluble exogenous antigens (endosomes) 43 3.20e-01 8.78e-02 6.84e-01
Regulation of HSF1-mediated heat shock response 67 2.15e-01 8.77e-02 5.75e-01
Elevation of cytosolic Ca2+ levels 11 6.15e-01 -8.76e-02 8.78e-01
RIPK1-mediated regulated necrosis 14 5.72e-01 -8.74e-02 8.56e-01
Regulated Necrosis 14 5.72e-01 -8.74e-02 8.56e-01
Endogenous sterols 14 5.72e-01 8.72e-02 8.56e-01
Surfactant metabolism 12 6.01e-01 8.71e-02 8.65e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 5.11e-01 -8.71e-02 8.35e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 5.11e-01 -8.71e-02 8.35e-01
Notch-HLH transcription pathway 25 4.51e-01 8.71e-02 7.99e-01
Intracellular signaling by second messengers 256 1.71e-02 8.70e-02 1.52e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 24 4.61e-01 8.70e-02 8.07e-01
Defects in vitamin and cofactor metabolism 18 5.27e-01 -8.62e-02 8.39e-01
G-protein mediated events 44 3.24e-01 8.60e-02 6.86e-01
Signalling to ERKs 30 4.15e-01 8.60e-02 7.75e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 6.38e-01 -8.58e-02 8.88e-01
STING mediated induction of host immune responses 10 6.39e-01 -8.57e-02 8.88e-01
HIV Life Cycle 127 9.86e-02 -8.51e-02 4.01e-01
Signaling by VEGF 96 1.52e-01 8.48e-02 4.84e-01
Caspase activation via Death Receptors in the presence of ligand 13 6.00e-01 -8.41e-02 8.65e-01
Formation of RNA Pol II elongation complex 51 3.00e-01 -8.40e-02 6.61e-01
RNA Polymerase II Transcription Elongation 51 3.00e-01 -8.40e-02 6.61e-01
Transcriptional regulation of pluripotent stem cells 13 6.02e-01 -8.36e-02 8.65e-01
VxPx cargo-targeting to cilium 17 5.52e-01 8.33e-02 8.48e-01
Activation of NF-kappaB in B cells 57 2.79e-01 8.31e-02 6.44e-01
PLC beta mediated events 43 3.50e-01 8.24e-02 7.15e-01
mRNA decay by 3' to 5' exoribonuclease 15 5.81e-01 8.24e-02 8.58e-01
Processing of Capped Intronless Pre-mRNA 25 4.77e-01 8.22e-02 8.14e-01
TP53 Regulates Transcription of Cell Cycle Genes 39 3.75e-01 8.21e-02 7.37e-01
Signaling by Hippo 18 5.48e-01 8.18e-02 8.47e-01
RNA Polymerase III Chain Elongation 17 5.60e-01 -8.18e-02 8.49e-01
Chaperonin-mediated protein folding 70 2.38e-01 8.17e-02 6.04e-01
TP53 Regulates Transcription of DNA Repair Genes 52 3.09e-01 -8.16e-02 6.72e-01
Purine ribonucleoside monophosphate biosynthesis 12 6.25e-01 8.15e-02 8.84e-01
Activation of BH3-only proteins 26 4.72e-01 8.15e-02 8.14e-01
Inositol phosphate metabolism 41 3.67e-01 8.15e-02 7.32e-01
Meiotic synapsis 23 4.99e-01 -8.14e-02 8.29e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 5.99e-01 8.12e-02 8.65e-01
mRNA Splicing - Major Pathway 162 7.63e-02 -8.10e-02 3.49e-01
FOXO-mediated transcription 57 2.92e-01 8.08e-02 6.56e-01
Downstream signaling of activated FGFR1 20 5.32e-01 8.07e-02 8.39e-01
DAG and IP3 signaling 36 4.04e-01 8.04e-02 7.75e-01
MAPK6/MAPK4 signaling 73 2.36e-01 8.03e-02 6.02e-01
G1/S Transition 109 1.49e-01 8.03e-02 4.79e-01
Downstream signaling events of B Cell Receptor (BCR) 68 2.53e-01 8.02e-02 6.20e-01
mRNA Splicing 170 7.26e-02 -8.01e-02 3.41e-01
Signaling by NTRK1 (TRKA) 102 1.63e-01 8.01e-02 5.03e-01
Integrin signaling 26 4.80e-01 8.01e-02 8.14e-01
G alpha (i) signalling events 165 7.70e-02 8.00e-02 3.49e-01
Downstream signaling of activated FGFR3 17 5.69e-01 7.99e-02 8.53e-01
HDACs deacetylate histones 30 4.49e-01 7.99e-02 7.99e-01
PI-3K cascade:FGFR2 11 6.48e-01 -7.95e-02 8.92e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 3.51e-01 7.95e-02 7.16e-01
Pre-NOTCH Processing in Golgi 16 5.84e-01 7.91e-02 8.58e-01
VEGFA-VEGFR2 Pathway 88 2.01e-01 7.90e-02 5.57e-01
SHC1 events in ERBB2 signaling 16 5.84e-01 7.90e-02 8.58e-01
APC-Cdc20 mediated degradation of Nek2A 21 5.32e-01 -7.89e-02 8.39e-01
Molecules associated with elastic fibres 26 4.88e-01 7.86e-02 8.21e-01
Developmental Biology 620 9.88e-04 7.85e-02 2.58e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 21 5.34e-01 7.84e-02 8.39e-01
Trafficking of AMPA receptors 21 5.34e-01 7.84e-02 8.39e-01
Transcriptional regulation by small RNAs 40 3.92e-01 7.83e-02 7.58e-01
Toll-like Receptor Cascades 130 1.24e-01 7.83e-02 4.38e-01
Integrin cell surface interactions 54 3.20e-01 7.83e-02 6.84e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 47 3.54e-01 7.82e-02 7.20e-01
COPII-mediated vesicle transport 56 3.13e-01 7.81e-02 6.74e-01
Fatty acid metabolism 125 1.34e-01 -7.77e-02 4.58e-01
Antiviral mechanism by IFN-stimulated genes 64 2.84e-01 7.75e-02 6.47e-01
Iron uptake and transport 45 3.69e-01 -7.75e-02 7.32e-01
ISG15 antiviral mechanism 59 3.04e-01 7.75e-02 6.66e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 6.29e-01 7.74e-02 8.88e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 6.17e-01 7.73e-02 8.78e-01
Assembly of the pre-replicative complex 58 3.10e-01 7.72e-02 6.72e-01
Signaling by EGFR in Cancer 19 5.62e-01 7.69e-02 8.50e-01
Organelle biogenesis and maintenance 228 4.70e-02 -7.67e-02 2.76e-01
Diseases of signal transduction by growth factor receptors and second messengers 319 2.04e-02 7.60e-02 1.72e-01
AMER1 mutants destabilize the destruction complex 13 6.37e-01 7.57e-02 8.88e-01
APC truncation mutants have impaired AXIN binding 13 6.37e-01 7.57e-02 8.88e-01
AXIN missense mutants destabilize the destruction complex 13 6.37e-01 7.57e-02 8.88e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 6.37e-01 7.57e-02 8.88e-01
Truncations of AMER1 destabilize the destruction complex 13 6.37e-01 7.57e-02 8.88e-01
truncated APC mutants destabilize the destruction complex 13 6.37e-01 7.57e-02 8.88e-01
Signaling by GPCR 345 1.65e-02 7.56e-02 1.50e-01
Activation of gene expression by SREBF (SREBP) 40 4.09e-01 7.56e-02 7.75e-01
PKMTs methylate histone lysines 37 4.28e-01 -7.54e-02 7.88e-01
DAP12 signaling 21 5.50e-01 7.54e-02 8.48e-01
Glucose metabolism 76 2.59e-01 -7.50e-02 6.23e-01
Adrenaline,noradrenaline inhibits insulin secretion 18 5.84e-01 7.46e-02 8.58e-01
Nervous system development 408 1.06e-02 7.44e-02 1.23e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 85 2.40e-01 7.38e-02 6.04e-01
Toll Like Receptor 2 (TLR2) Cascade 85 2.40e-01 7.38e-02 6.04e-01
Toll Like Receptor TLR1:TLR2 Cascade 85 2.40e-01 7.38e-02 6.04e-01
Toll Like Receptor TLR6:TLR2 Cascade 85 2.40e-01 7.38e-02 6.04e-01
FGFR2 alternative splicing 22 5.50e-01 -7.36e-02 8.48e-01
RHO GTPases Activate NADPH Oxidases 17 6.00e-01 7.35e-02 8.65e-01
Formation of Fibrin Clot (Clotting Cascade) 21 5.63e-01 7.29e-02 8.50e-01
Signaling by FGFR3 fusions in cancer 10 6.90e-01 7.28e-02 9.13e-01
Adaptive Immune System 520 5.07e-03 7.26e-02 7.34e-02
Prefoldin mediated transfer of substrate to CCT/TriC 22 5.60e-01 7.18e-02 8.49e-01
TBC/RABGAPs 40 4.34e-01 7.15e-02 7.90e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 85 2.56e-01 -7.14e-02 6.22e-01
Retinoid metabolism and transport 28 5.14e-01 7.13e-02 8.37e-01
Axon guidance 388 1.68e-02 7.13e-02 1.51e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 54 3.66e-01 7.12e-02 7.32e-01
Protein methylation 10 6.98e-01 7.10e-02 9.16e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.95e-01 -7.09e-02 8.25e-01
tRNA processing 99 2.26e-01 7.06e-02 5.89e-01
Synthesis of pyrophosphates in the cytosol 10 7.00e-01 -7.05e-02 9.16e-01
Signaling by TGF-beta Receptor Complex 67 3.20e-01 7.03e-02 6.84e-01
Deadenylation of mRNA 24 5.54e-01 6.99e-02 8.48e-01
Protein folding 76 2.93e-01 6.98e-02 6.56e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 40 4.45e-01 6.98e-02 7.95e-01
FRS-mediated FGFR4 signaling 13 6.64e-01 6.96e-02 8.95e-01
Cellular responses to external stimuli 413 1.62e-02 6.96e-02 1.49e-01
Incretin synthesis, secretion, and inactivation 10 7.03e-01 -6.95e-02 9.18e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 7.03e-01 -6.95e-02 9.18e-01
Vasopressin regulates renal water homeostasis via Aquaporins 30 5.11e-01 6.94e-02 8.35e-01
Aquaporin-mediated transport 32 4.98e-01 6.93e-02 8.28e-01
Sphingolipid de novo biosynthesis 33 4.91e-01 6.93e-02 8.23e-01
HATs acetylate histones 72 3.12e-01 -6.90e-02 6.74e-01
SUMOylation of transcription factors 14 6.56e-01 6.88e-02 8.93e-01
Regulation of TNFR1 signaling 26 5.45e-01 6.87e-02 8.44e-01
Platelet activation, signaling and aggregation 209 8.87e-02 6.86e-02 3.78e-01
Constitutive Signaling by EGFRvIII 15 6.46e-01 6.84e-02 8.92e-01
Signaling by EGFRvIII in Cancer 15 6.46e-01 6.84e-02 8.92e-01
Cholesterol biosynthesis 22 5.80e-01 -6.82e-02 8.58e-01
Signaling by FGFR1 in disease 32 5.06e-01 -6.80e-02 8.34e-01
Disease 1045 2.90e-04 6.78e-02 1.06e-02
Platelet homeostasis 64 3.50e-01 6.77e-02 7.15e-01
Degradation of GLI1 by the proteasome 51 4.04e-01 -6.76e-02 7.75e-01
G alpha (z) signalling events 33 5.03e-01 6.75e-02 8.32e-01
SCF(Skp2)-mediated degradation of p27/p21 50 4.10e-01 6.74e-02 7.75e-01
Diseases associated with N-glycosylation of proteins 16 6.41e-01 6.73e-02 8.88e-01
tRNA modification in the nucleus and cytosol 37 4.80e-01 6.71e-02 8.14e-01
Metabolism of amino acids and derivatives 234 7.84e-02 -6.71e-02 3.50e-01
Downstream signal transduction 28 5.40e-01 6.69e-02 8.41e-01
Golgi Associated Vesicle Biogenesis 50 4.17e-01 6.64e-02 7.75e-01
Signal Transduction 1561 2.87e-05 6.57e-02 1.92e-03
Sphingolipid metabolism 67 3.56e-01 6.53e-02 7.22e-01
Regulation of PTEN mRNA translation 11 7.08e-01 -6.53e-02 9.20e-01
Signaling by FGFR in disease 49 4.31e-01 -6.51e-02 7.89e-01
Cargo concentration in the ER 20 6.16e-01 6.48e-02 8.78e-01
Mitophagy 24 5.83e-01 -6.48e-02 8.58e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 71 3.48e-01 6.45e-02 7.14e-01
Nonsense-Mediated Decay (NMD) 71 3.48e-01 6.45e-02 7.14e-01
MECP2 regulates neuronal receptors and channels 11 7.11e-01 -6.44e-02 9.20e-01
Signaling by FGFR2 54 4.14e-01 -6.44e-02 7.75e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 17 6.47e-01 6.42e-02 8.92e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 67 3.64e-01 6.42e-02 7.32e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 7.13e-01 -6.40e-02 9.20e-01
MyD88-independent TLR4 cascade 88 3.00e-01 6.40e-02 6.61e-01
TRIF(TICAM1)-mediated TLR4 signaling 88 3.00e-01 6.40e-02 6.61e-01
Transferrin endocytosis and recycling 22 6.04e-01 -6.39e-02 8.67e-01
LDL clearance 16 6.58e-01 6.39e-02 8.93e-01
Intraflagellar transport 36 5.09e-01 -6.37e-02 8.34e-01
Infectious disease 526 1.36e-02 6.36e-02 1.42e-01
Cellular responses to stress 408 2.90e-02 6.35e-02 2.14e-01
Triglyceride metabolism 24 5.91e-01 -6.34e-02 8.62e-01
TNFR2 non-canonical NF-kB pathway 67 3.71e-01 6.33e-02 7.33e-01
Effects of PIP2 hydrolysis 18 6.42e-01 -6.33e-02 8.88e-01
Purine salvage 12 7.05e-01 6.32e-02 9.19e-01
Formation of the beta-catenin:TCF transactivating complex 28 5.64e-01 -6.30e-02 8.50e-01
DNA strand elongation 30 5.53e-01 -6.26e-02 8.48e-01
L13a-mediated translational silencing of Ceruloplasmin expression 65 3.86e-01 6.23e-02 7.49e-01
Mitotic G1 phase and G1/S transition 125 2.33e-01 6.20e-02 6.00e-01
Interleukin-6 family signaling 17 6.59e-01 6.19e-02 8.93e-01
Plasma lipoprotein assembly, remodeling, and clearance 53 4.37e-01 -6.18e-02 7.90e-01
ABC transporters in lipid homeostasis 14 6.89e-01 -6.18e-02 9.13e-01
Regulated proteolysis of p75NTR 11 7.23e-01 6.17e-02 9.26e-01
Cytosolic sensors of pathogen-associated DNA 54 4.34e-01 6.17e-02 7.90e-01
Early Phase of HIV Life Cycle 11 7.24e-01 6.15e-02 9.26e-01
Transcriptional Regulation by VENTX 35 5.31e-01 6.12e-02 8.39e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 27 5.82e-01 6.12e-02 8.58e-01
GPCR downstream signalling 317 6.28e-02 6.12e-02 3.25e-01
Glycosphingolipid metabolism 34 5.37e-01 6.12e-02 8.39e-01
Metabolism of water-soluble vitamins and cofactors 96 3.02e-01 6.10e-02 6.64e-01
TNFR1-induced proapoptotic signaling 12 7.15e-01 -6.09e-02 9.20e-01
Intrinsic Pathway for Apoptosis 43 4.90e-01 6.09e-02 8.23e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 20 6.39e-01 6.07e-02 8.88e-01
MAPK family signaling cascades 245 1.05e-01 6.05e-02 4.08e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 17 6.67e-01 6.03e-02 8.95e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 17 6.67e-01 6.03e-02 8.95e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 7.29e-01 -6.03e-02 9.27e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 5.55e-01 -6.03e-02 8.48e-01
Toll Like Receptor 3 (TLR3) Cascade 86 3.36e-01 6.01e-02 7.06e-01
SHC-mediated cascade:FGFR1 11 7.31e-01 5.98e-02 9.27e-01
Ribosomal scanning and start codon recognition 41 5.08e-01 5.97e-02 8.34e-01
SARS-CoV-1 Infection 43 5.00e-01 5.96e-02 8.29e-01
CLEC7A (Dectin-1) induces NFAT activation 10 7.46e-01 5.91e-02 9.27e-01
CRMPs in Sema3A signaling 13 7.13e-01 5.88e-02 9.20e-01
Deubiquitination 213 1.41e-01 5.88e-02 4.66e-01
Regulation of FZD by ubiquitination 11 7.37e-01 5.85e-02 9.27e-01
Transcriptional Regulation by TP53 305 8.13e-02 -5.84e-02 3.61e-01
ERK/MAPK targets 22 6.37e-01 -5.82e-02 8.88e-01
GLI3 is processed to GLI3R by the proteasome 50 4.80e-01 -5.79e-02 8.14e-01
Macroautophagy 102 3.14e-01 -5.78e-02 6.76e-01
Deadenylation-dependent mRNA decay 52 4.72e-01 5.77e-02 8.14e-01
Degradation of GLI2 by the proteasome 50 4.81e-01 -5.77e-02 8.14e-01
Apoptotic factor-mediated response 13 7.19e-01 5.77e-02 9.23e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 80 3.74e-01 5.76e-02 7.37e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 6.73e-01 5.76e-02 8.99e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 41 5.25e-01 5.74e-02 8.39e-01
Carnitine metabolism 12 7.31e-01 5.74e-02 9.27e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 7.53e-01 5.74e-02 9.27e-01
Signaling by Nuclear Receptors 188 1.77e-01 5.73e-02 5.18e-01
NCAM1 interactions 25 6.21e-01 5.71e-02 8.81e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 12 7.34e-01 5.67e-02 9.27e-01
Signaling by high-kinase activity BRAF mutants 33 5.74e-01 5.66e-02 8.57e-01
RHO GTPase Effectors 187 1.83e-01 5.66e-02 5.30e-01
Hedgehog ligand biogenesis 51 4.86e-01 5.64e-02 8.20e-01
Class I MHC mediated antigen processing & presentation 313 8.91e-02 5.62e-02 3.78e-01
Plasma lipoprotein remodeling 21 6.56e-01 -5.62e-02 8.93e-01
RAF-independent MAPK1/3 activation 20 6.66e-01 5.57e-02 8.95e-01
Resolution of Sister Chromatid Cohesion 68 4.31e-01 -5.52e-02 7.89e-01
Signaling by ERBB4 39 5.52e-01 5.51e-02 8.48e-01
activated TAK1 mediates p38 MAPK activation 18 6.87e-01 5.48e-02 9.11e-01
Signaling by NOTCH1 64 4.49e-01 5.47e-02 7.99e-01
Ub-specific processing proteases 145 2.58e-01 5.46e-02 6.23e-01
Purine catabolism 16 7.07e-01 -5.44e-02 9.20e-01
PI3K events in ERBB2 signaling 10 7.68e-01 5.40e-02 9.37e-01
Metabolism of fat-soluble vitamins 31 6.05e-01 5.37e-02 8.68e-01
Processing of Capped Intron-Containing Pre-mRNA 214 1.78e-01 -5.37e-02 5.18e-01
Uptake and function of anthrax toxins 11 7.58e-01 5.36e-02 9.30e-01
Synthesis of PIPs at the late endosome membrane 10 7.70e-01 -5.34e-02 9.37e-01
MyD88 cascade initiated on plasma membrane 77 4.19e-01 5.33e-02 7.76e-01
Toll Like Receptor 10 (TLR10) Cascade 77 4.19e-01 5.33e-02 7.76e-01
Toll Like Receptor 5 (TLR5) Cascade 77 4.19e-01 5.33e-02 7.76e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 19 6.88e-01 -5.33e-02 9.11e-01
Positive epigenetic regulation of rRNA expression 44 5.41e-01 5.33e-02 8.41e-01
Regulation of APC/C activators between G1/S and early anaphase 65 4.62e-01 -5.28e-02 8.07e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 7.24e-01 -5.27e-02 9.26e-01
Signaling by NOTCH 154 2.64e-01 5.23e-02 6.27e-01
MyD88 dependent cascade initiated on endosome 81 4.17e-01 5.23e-02 7.75e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 81 4.17e-01 5.23e-02 7.75e-01
Neurexins and neuroligins 27 6.41e-01 5.18e-02 8.88e-01
Peptide hormone metabolism 48 5.38e-01 -5.15e-02 8.39e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 51 5.27e-01 5.13e-02 8.39e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 51 5.27e-01 5.13e-02 8.39e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 51 5.27e-01 5.13e-02 8.39e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 51 5.27e-01 5.13e-02 8.39e-01
Signaling by NOTCH1 in Cancer 51 5.27e-01 5.13e-02 8.39e-01
Synthesis of DNA 104 3.68e-01 -5.12e-02 7.32e-01
Translation initiation complex formation 40 5.84e-01 5.00e-02 8.58e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 7.10e-01 4.93e-02 9.20e-01
Mitotic Spindle Checkpoint 77 4.56e-01 -4.92e-02 8.02e-01
Deactivation of the beta-catenin transactivating complex 34 6.20e-01 -4.91e-02 8.81e-01
Signaling by FGFR1 35 6.17e-01 4.89e-02 8.78e-01
G1/S DNA Damage Checkpoints 55 5.32e-01 4.88e-02 8.39e-01
Class B/2 (Secretin family receptors) 42 5.85e-01 -4.87e-02 8.58e-01
G beta:gamma signalling through BTK 11 7.80e-01 4.87e-02 9.43e-01
Kinesins 21 7.00e-01 4.86e-02 9.16e-01
RHO GTPases activate PKNs 32 6.34e-01 -4.86e-02 8.88e-01
Misspliced GSK3beta mutants stabilize beta-catenin 14 7.54e-01 4.84e-02 9.27e-01
S33 mutants of beta-catenin aren't phosphorylated 14 7.54e-01 4.84e-02 9.27e-01
S37 mutants of beta-catenin aren't phosphorylated 14 7.54e-01 4.84e-02 9.27e-01
S45 mutants of beta-catenin aren't phosphorylated 14 7.54e-01 4.84e-02 9.27e-01
T41 mutants of beta-catenin aren't phosphorylated 14 7.54e-01 4.84e-02 9.27e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 7.54e-01 4.84e-02 9.27e-01
Ubiquitin-dependent degradation of Cyclin D 44 5.80e-01 4.82e-02 8.58e-01
Signaling by BRAF and RAF fusions 57 5.29e-01 4.82e-02 8.39e-01
RAB geranylgeranylation 42 5.95e-01 -4.75e-02 8.65e-01
Formation of a pool of free 40S subunits 57 5.36e-01 4.74e-02 8.39e-01
Rho GTPase cycle 116 3.80e-01 4.73e-02 7.41e-01
RNA Polymerase I Promoter Clearance 47 5.76e-01 -4.72e-02 8.58e-01
tRNA processing in the nucleus 50 5.67e-01 4.68e-02 8.52e-01
PI-3K cascade:FGFR1 11 7.89e-01 -4.66e-02 9.49e-01
Regulation of ornithine decarboxylase (ODC) 44 5.95e-01 4.64e-02 8.65e-01
RNA Polymerase II Transcription Termination 59 5.39e-01 -4.63e-02 8.40e-01
PPARA activates gene expression 105 4.15e-01 4.62e-02 7.75e-01
Arachidonic acid metabolism 34 6.42e-01 -4.61e-02 8.88e-01
Cellular response to hypoxia 62 5.31e-01 4.60e-02 8.39e-01
Platelet degranulation 107 4.12e-01 4.60e-02 7.75e-01
MTOR signalling 39 6.19e-01 -4.60e-02 8.81e-01
Response to elevated platelet cytosolic Ca2+ 111 4.05e-01 4.59e-02 7.75e-01
Sema4D in semaphorin signaling 24 6.98e-01 4.59e-02 9.16e-01
cGMP effects 10 8.03e-01 4.55e-02 9.50e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 6.83e-01 -4.54e-02 9.10e-01
Signaling by Rho GTPases 294 1.84e-01 4.53e-02 5.30e-01
Activation of kainate receptors upon glutamate binding 19 7.34e-01 4.51e-02 9.27e-01
Toll Like Receptor 9 (TLR9) Cascade 84 4.78e-01 4.49e-02 8.14e-01
Hh mutants abrogate ligand secretion 48 5.91e-01 4.48e-02 8.62e-01
ER Quality Control Compartment (ERQC) 18 7.42e-01 4.48e-02 9.27e-01
Opioid Signalling 69 5.23e-01 4.45e-02 8.39e-01
Orc1 removal from chromatin 59 5.56e-01 4.43e-02 8.49e-01
SUMOylation of chromatin organization proteins 47 6.01e-01 4.42e-02 8.65e-01
DNA Replication 108 4.29e-01 -4.41e-02 7.89e-01
RAS processing 19 7.40e-01 -4.40e-02 9.27e-01
Heme degradation 11 8.00e-01 4.40e-02 9.49e-01
MAPK1/MAPK3 signaling 213 2.71e-01 4.39e-02 6.34e-01
p53-Dependent G1 DNA Damage Response 54 5.81e-01 4.34e-02 8.58e-01
p53-Dependent G1/S DNA damage checkpoint 54 5.81e-01 4.34e-02 8.58e-01
FLT3 Signaling 222 2.68e-01 4.34e-02 6.32e-01
Signaling by NTRK3 (TRKC) 16 7.65e-01 -4.32e-02 9.35e-01
Cell-cell junction organization 24 7.15e-01 -4.31e-02 9.20e-01
Regulation of lipid metabolism by PPARalpha 107 4.44e-01 4.30e-02 7.94e-01
UCH proteinases 75 5.22e-01 4.28e-02 8.39e-01
Adherens junctions interactions 12 7.98e-01 4.27e-02 9.49e-01
Metabolism of carbohydrates 222 2.75e-01 4.27e-02 6.40e-01
Signaling by FGFR4 in disease 11 8.07e-01 4.25e-02 9.51e-01
Cap-dependent Translation Initiation 73 5.31e-01 4.24e-02 8.39e-01
Eukaryotic Translation Initiation 73 5.31e-01 4.24e-02 8.39e-01
Separation of Sister Chromatids 127 4.11e-01 -4.23e-02 7.75e-01
NOD1/2 Signaling Pathway 29 6.94e-01 4.22e-02 9.16e-01
Nuclear signaling by ERBB4 22 7.33e-01 4.20e-02 9.27e-01
Metabolism of steroids 97 4.77e-01 4.19e-02 8.14e-01
PCP/CE pathway 80 5.25e-01 4.12e-02 8.39e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 34 6.81e-01 4.08e-02 9.08e-01
G alpha (12/13) signalling events 60 5.87e-01 4.06e-02 8.60e-01
Ion channel transport 97 4.92e-01 -4.05e-02 8.23e-01
Caspase activation via extrinsic apoptotic signalling pathway 22 7.43e-01 4.03e-02 9.27e-01
N-Glycan antennae elongation 12 8.09e-01 4.02e-02 9.51e-01
Amino acids regulate mTORC1 48 6.31e-01 4.01e-02 8.88e-01
Programmed Cell Death 141 4.12e-01 4.01e-02 7.75e-01
Signaling by ROBO receptors 147 4.05e-01 3.99e-02 7.75e-01
NOTCH1 Intracellular Domain Regulates Transcription 42 6.55e-01 3.99e-02 8.93e-01
Common Pathway of Fibrin Clot Formation 13 8.05e-01 -3.96e-02 9.50e-01
rRNA modification in the nucleus and cytosol 52 6.22e-01 3.96e-02 8.82e-01
DNA Damage Recognition in GG-NER 35 6.86e-01 -3.95e-02 9.11e-01
TCR signaling 87 5.27e-01 3.93e-02 8.39e-01
Regulation of PTEN stability and activity 60 6.00e-01 3.92e-02 8.65e-01
Death Receptor Signalling 117 4.66e-01 3.91e-02 8.12e-01
RNA Polymerase I Transcription Initiation 44 6.58e-01 -3.86e-02 8.93e-01
Metabolism of porphyrins 23 7.50e-01 3.85e-02 9.27e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 7.98e-01 3.82e-02 9.49e-01
Epigenetic regulation of gene expression 83 5.50e-01 -3.80e-02 8.48e-01
Viral Messenger RNA Synthesis 36 6.95e-01 3.78e-02 9.16e-01
CD209 (DC-SIGN) signaling 18 7.82e-01 3.77e-02 9.44e-01
Signaling by WNT in cancer 28 7.30e-01 3.77e-02 9.27e-01
RNA Polymerase I Transcription 48 6.52e-01 -3.76e-02 8.93e-01
NR1H2 and NR1H3-mediated signaling 39 6.85e-01 -3.76e-02 9.11e-01
Repression of WNT target genes 11 8.29e-01 3.75e-02 9.56e-01
Activation of the pre-replicative complex 26 7.42e-01 3.73e-02 9.27e-01
Glycolysis 58 6.24e-01 -3.72e-02 8.84e-01
Clathrin-mediated endocytosis 112 4.98e-01 3.72e-02 8.28e-01
Beta-catenin phosphorylation cascade 15 8.04e-01 3.70e-02 9.50e-01
RAF/MAP kinase cascade 209 3.60e-01 3.69e-02 7.27e-01
SCF-beta-TrCP mediated degradation of Emi1 45 6.70e-01 -3.68e-02 8.98e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 6.67e-01 -3.68e-02 8.95e-01
Receptor Mediated Mitophagy 11 8.33e-01 -3.67e-02 9.56e-01
TGF-beta receptor signaling activates SMADs 29 7.33e-01 3.66e-02 9.27e-01
Ca2+ pathway 48 6.62e-01 -3.65e-02 8.95e-01
Listeria monocytogenes entry into host cells 15 8.08e-01 3.62e-02 9.51e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 7.97e-01 -3.61e-02 9.49e-01
DNA Double Strand Break Response 36 7.12e-01 -3.56e-02 9.20e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 36 7.12e-01 -3.56e-02 9.20e-01
Cellular Senescence 116 5.13e-01 3.52e-02 8.37e-01
Selective autophagy 52 6.61e-01 -3.52e-02 8.95e-01
Nucleobase catabolism 26 7.58e-01 3.49e-02 9.30e-01
Synthesis of PIPs at the plasma membrane 49 6.73e-01 3.49e-02 8.99e-01
Synaptic adhesion-like molecules 12 8.35e-01 3.47e-02 9.56e-01
FCERI mediated Ca+2 mobilization 22 7.79e-01 3.46e-02 9.42e-01
Asymmetric localization of PCP proteins 55 6.58e-01 3.46e-02 8.93e-01
ADP signalling through P2Y purinoceptor 1 18 8.00e-01 3.45e-02 9.49e-01
Integration of energy metabolism 80 5.96e-01 3.44e-02 8.65e-01
Condensation of Prophase Chromosomes 10 8.51e-01 3.42e-02 9.58e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 8.34e-01 3.35e-02 9.56e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 68 6.34e-01 -3.34e-02 8.88e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 60 6.55e-01 -3.34e-02 8.93e-01
Amplification of signal from the kinetochores 60 6.55e-01 -3.34e-02 8.93e-01
C-type lectin receptors (CLRs) 103 5.61e-01 3.32e-02 8.49e-01
Cytochrome c-mediated apoptotic response 10 8.56e-01 -3.32e-02 9.58e-01
HCMV Infection 72 6.30e-01 -3.29e-02 8.88e-01
Transport to the Golgi and subsequent modification 138 5.07e-01 3.28e-02 8.34e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 35 7.38e-01 3.27e-02 9.27e-01
Diseases of mitotic cell cycle 35 7.38e-01 3.27e-02 9.27e-01
HIV Infection 195 4.34e-01 -3.26e-02 7.90e-01
E2F mediated regulation of DNA replication 18 8.11e-01 -3.26e-02 9.51e-01
NRIF signals cell death from the nucleus 14 8.37e-01 3.18e-02 9.56e-01
Activation of HOX genes during differentiation 50 6.99e-01 -3.16e-02 9.16e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 50 6.99e-01 -3.16e-02 9.16e-01
Metabolism 1514 4.78e-02 -3.15e-02 2.76e-01
Metabolism of folate and pterines 14 8.41e-01 3.10e-02 9.56e-01
RHO GTPases activate CIT 18 8.21e-01 -3.08e-02 9.54e-01
Negative regulation of FGFR3 signaling 19 8.17e-01 3.07e-02 9.53e-01
Signaling by PDGFRA extracellular domain mutants 12 8.54e-01 -3.06e-02 9.58e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 8.54e-01 -3.06e-02 9.58e-01
G beta:gamma signalling through PLC beta 13 8.49e-01 -3.06e-02 9.58e-01
Presynaptic function of Kainate receptors 13 8.49e-01 -3.06e-02 9.58e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 29 7.77e-01 3.04e-02 9.42e-01
Autophagy 113 5.79e-01 -3.03e-02 8.58e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 25 7.95e-01 -3.01e-02 9.49e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 10 8.69e-01 3.00e-02 9.65e-01
SUMOylation of intracellular receptors 23 8.04e-01 2.99e-02 9.50e-01
Degradation of beta-catenin by the destruction complex 72 6.64e-01 -2.96e-02 8.95e-01
TP53 Regulates Metabolic Genes 78 6.52e-01 2.96e-02 8.93e-01
Spry regulation of FGF signaling 14 8.50e-01 -2.91e-02 9.58e-01
COPI-mediated anterograde transport 74 6.66e-01 -2.91e-02 8.95e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 7.44e-01 2.91e-02 9.27e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 147 5.45e-01 2.90e-02 8.44e-01
Downstream signaling of activated FGFR2 18 8.32e-01 2.89e-02 9.56e-01
Glucagon-type ligand receptors 16 8.43e-01 -2.87e-02 9.56e-01
Oncogenic MAPK signaling 73 6.73e-01 2.86e-02 8.99e-01
Metabolism of vitamins and cofactors 144 5.55e-01 2.86e-02 8.48e-01
Cyclin D associated events in G1 41 7.53e-01 -2.84e-02 9.27e-01
G1 Phase 41 7.53e-01 -2.84e-02 9.27e-01
Degradation of DVL 48 7.34e-01 -2.84e-02 9.27e-01
SUMOylation 140 5.66e-01 -2.82e-02 8.51e-01
Diseases of metabolism 168 5.36e-01 2.78e-02 8.39e-01
Negative regulation of FGFR4 signaling 20 8.31e-01 -2.76e-02 9.56e-01
IRS-mediated signalling 30 7.94e-01 2.76e-02 9.49e-01
Oncogene Induced Senescence 30 7.94e-01 2.75e-02 9.49e-01
Apoptosis 138 5.84e-01 2.71e-02 8.58e-01
APC/C:Cdc20 mediated degradation of Securin 59 7.20e-01 -2.70e-02 9.24e-01
SHC-mediated cascade:FGFR2 11 8.77e-01 2.69e-02 9.69e-01
Apoptotic execution phase 35 7.84e-01 2.68e-02 9.45e-01
Rap1 signalling 14 8.63e-01 -2.67e-02 9.62e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 46 7.54e-01 2.67e-02 9.27e-01
PIWI-interacting RNA (piRNA) biogenesis 13 8.68e-01 2.65e-02 9.65e-01
Regulation of PLK1 Activity at G2/M Transition 74 6.94e-01 -2.65e-02 9.16e-01
Cyclin A/B1/B2 associated events during G2/M transition 16 8.55e-01 -2.65e-02 9.58e-01
Cell Cycle, Mitotic 399 3.68e-01 2.65e-02 7.32e-01
Formation of the ternary complex, and subsequently, the 43S complex 34 7.91e-01 2.63e-02 9.49e-01
Triglyceride catabolism 16 8.56e-01 -2.62e-02 9.58e-01
RNA polymerase II transcribes snRNA genes 68 7.10e-01 -2.61e-02 9.20e-01
TCF dependent signaling in response to WNT 137 6.00e-01 2.60e-02 8.65e-01
RNA Polymerase III Abortive And Retractive Initiation 39 7.79e-01 -2.60e-02 9.42e-01
RNA Polymerase III Transcription 39 7.79e-01 -2.60e-02 9.42e-01
PI3K Cascade 26 8.19e-01 2.60e-02 9.53e-01
Post-translational protein phosphorylation 77 6.95e-01 -2.59e-02 9.16e-01
RNA Polymerase I Transcription Termination 29 8.13e-01 -2.54e-02 9.51e-01
Regulation of RAS by GAPs 57 7.43e-01 2.52e-02 9.27e-01
Glycerophospholipid biosynthesis 87 6.86e-01 2.52e-02 9.11e-01
Autodegradation of the E3 ubiquitin ligase COP1 44 7.73e-01 2.51e-02 9.39e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 63 7.31e-01 -2.51e-02 9.27e-01
Stabilization of p53 48 7.65e-01 2.50e-02 9.35e-01
Assembly Of The HIV Virion 12 8.81e-01 2.49e-02 9.69e-01
Regulation of expression of SLITs and ROBOs 108 6.57e-01 2.48e-02 8.93e-01
Nuclear Receptor transcription pathway 37 7.94e-01 2.48e-02 9.49e-01
Heme biosynthesis 14 8.72e-01 -2.48e-02 9.67e-01
Circadian Clock 62 7.40e-01 -2.44e-02 9.27e-01
Late endosomal microautophagy 25 8.33e-01 -2.44e-02 9.56e-01
Sema4D induced cell migration and growth-cone collapse 20 8.51e-01 2.43e-02 9.58e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 61 7.45e-01 -2.41e-02 9.27e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 61 7.45e-01 -2.41e-02 9.27e-01
Role of phospholipids in phagocytosis 21 8.49e-01 -2.40e-02 9.58e-01
SUMOylation of DNA damage response and repair proteins 64 7.41e-01 -2.39e-02 9.27e-01
Transport of vitamins, nucleosides, and related molecules 28 8.27e-01 -2.38e-02 9.56e-01
Insulin receptor recycling 18 8.62e-01 -2.36e-02 9.62e-01
HCMV Early Events 52 7.73e-01 2.32e-02 9.39e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 54 7.69e-01 2.31e-02 9.37e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 11 8.95e-01 2.30e-02 9.70e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 11 8.95e-01 2.30e-02 9.70e-01
Visual phototransduction 48 7.83e-01 -2.30e-02 9.45e-01
CLEC7A (Dectin-1) signaling 85 7.15e-01 2.29e-02 9.20e-01
DNA Replication Pre-Initiation 70 7.41e-01 2.28e-02 9.27e-01
Signaling by FGFR4 30 8.29e-01 -2.28e-02 9.56e-01
mTORC1-mediated signalling 22 8.54e-01 -2.26e-02 9.58e-01
Insulin receptor signalling cascade 35 8.19e-01 -2.24e-02 9.53e-01
Membrane binding and targetting of GAG proteins 10 9.03e-01 -2.22e-02 9.70e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 10 9.03e-01 -2.22e-02 9.70e-01
Thrombin signalling through proteinase activated receptors (PARs) 24 8.51e-01 -2.22e-02 9.58e-01
Signaling by FGFR3 in disease 14 8.88e-01 2.17e-02 9.70e-01
Signaling by FGFR3 point mutants in cancer 14 8.88e-01 2.17e-02 9.70e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.02e-01 2.15e-02 9.70e-01
CDT1 association with the CDC6:ORC:origin complex 49 7.97e-01 2.13e-02 9.49e-01
Activation of SMO 13 8.94e-01 2.13e-02 9.70e-01
Signaling by the B Cell Receptor (BCR) 91 7.27e-01 2.12e-02 9.27e-01
Infection with Mycobacterium tuberculosis 23 8.61e-01 -2.12e-02 9.61e-01
Negative regulation of NOTCH4 signaling 48 8.01e-01 -2.11e-02 9.49e-01
Vpu mediated degradation of CD4 43 8.12e-01 -2.10e-02 9.51e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 9.00e-01 -2.10e-02 9.70e-01
Cilium Assembly 161 6.50e-01 -2.08e-02 8.93e-01
Stimuli-sensing channels 44 8.12e-01 -2.08e-02 9.51e-01
Inwardly rectifying K+ channels 18 8.79e-01 2.07e-02 9.69e-01
Signaling by Hedgehog 115 7.03e-01 2.06e-02 9.18e-01
Tie2 Signaling 16 8.89e-01 2.01e-02 9.70e-01
Defective CFTR causes cystic fibrosis 50 8.07e-01 2.00e-02 9.51e-01
Interleukin-17 signaling 62 7.87e-01 1.99e-02 9.48e-01
Vif-mediated degradation of APOBEC3G 43 8.23e-01 -1.98e-02 9.54e-01
G alpha (q) signalling events 97 7.39e-01 1.96e-02 9.27e-01
Sialic acid metabolism 25 8.65e-01 1.96e-02 9.64e-01
Role of LAT2/NTAL/LAB on calcium mobilization 12 9.08e-01 -1.93e-02 9.74e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 60 7.98e-01 -1.91e-02 9.49e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 7.98e-01 -1.91e-02 9.49e-01
Cell Cycle Checkpoints 193 6.52e-01 -1.89e-02 8.93e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 23 8.76e-01 1.88e-02 9.69e-01
MicroRNA (miRNA) biogenesis 22 8.83e-01 1.82e-02 9.69e-01
Vesicle-mediated transport 528 4.92e-01 1.77e-02 8.23e-01
Negative epigenetic regulation of rRNA expression 47 8.38e-01 -1.73e-02 9.56e-01
Metabolism of non-coding RNA 45 8.42e-01 -1.71e-02 9.56e-01
snRNP Assembly 45 8.42e-01 -1.71e-02 9.56e-01
ER to Golgi Anterograde Transport 115 7.54e-01 -1.70e-02 9.27e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 31 8.72e-01 -1.68e-02 9.66e-01
Beta-catenin independent WNT signaling 121 7.53e-01 1.66e-02 9.27e-01
CDK-mediated phosphorylation and removal of Cdc6 61 8.24e-01 -1.65e-02 9.55e-01
Unblocking of NMDA receptors, glutamate binding and activation 10 9.28e-01 -1.64e-02 9.77e-01
Fc epsilon receptor (FCERI) signaling 111 7.68e-01 1.62e-02 9.37e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 51 8.43e-01 -1.60e-02 9.56e-01
Golgi-to-ER retrograde transport 86 7.99e-01 1.59e-02 9.49e-01
Centrosome maturation 72 8.17e-01 -1.58e-02 9.53e-01
Recruitment of mitotic centrosome proteins and complexes 72 8.17e-01 -1.58e-02 9.53e-01
Switching of origins to a post-replicative state 78 8.13e-01 1.55e-02 9.51e-01
Signaling by FGFR3 29 8.85e-01 1.55e-02 9.69e-01
DNA Damage/Telomere Stress Induced Senescence 24 8.96e-01 1.54e-02 9.70e-01
Apoptotic cleavage of cellular proteins 28 8.90e-01 1.51e-02 9.70e-01
ABC transporter disorders 60 8.40e-01 1.50e-02 9.56e-01
AURKA Activation by TPX2 62 8.39e-01 1.50e-02 9.56e-01
Transport of Mature Transcript to Cytoplasm 72 8.27e-01 1.49e-02 9.56e-01
M Phase 278 6.73e-01 1.48e-02 8.99e-01
APC/C-mediated degradation of cell cycle proteins 70 8.34e-01 -1.45e-02 9.56e-01
Regulation of mitotic cell cycle 70 8.34e-01 -1.45e-02 9.56e-01
RAF activation 34 8.84e-01 -1.45e-02 9.69e-01
Dectin-1 mediated noncanonical NF-kB signaling 51 8.58e-01 1.45e-02 9.59e-01
Cargo trafficking to the periciliary membrane 44 8.69e-01 1.43e-02 9.65e-01
Keratan sulfate degradation 11 9.35e-01 1.43e-02 9.80e-01
Activation of G protein gated Potassium channels 14 9.26e-01 1.43e-02 9.76e-01
G protein gated Potassium channels 14 9.26e-01 1.43e-02 9.76e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 14 9.26e-01 1.43e-02 9.76e-01
p130Cas linkage to MAPK signaling for integrins 15 9.25e-01 1.40e-02 9.76e-01
Mitotic G2-G2/M phases 156 7.63e-01 1.40e-02 9.35e-01
Anchoring of the basal body to the plasma membrane 83 8.26e-01 -1.40e-02 9.56e-01
FCERI mediated MAPK activation 27 9.02e-01 1.37e-02 9.70e-01
Thromboxane signalling through TP receptor 17 9.22e-01 1.37e-02 9.76e-01
Deposition of new CENPA-containing nucleosomes at the centromere 17 9.22e-01 1.37e-02 9.76e-01
Nucleosome assembly 17 9.22e-01 1.37e-02 9.76e-01
Regulation of RUNX2 expression and activity 61 8.54e-01 1.36e-02 9.58e-01
Oxidative Stress Induced Senescence 60 8.57e-01 -1.35e-02 9.58e-01
RNA Polymerase III Transcription Initiation 34 8.93e-01 -1.34e-02 9.70e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 42 8.85e-01 -1.29e-02 9.69e-01
Signaling by RAS mutants 42 8.85e-01 -1.29e-02 9.69e-01
Signaling by moderate kinase activity BRAF mutants 42 8.85e-01 -1.29e-02 9.69e-01
Signaling downstream of RAS mutants 42 8.85e-01 -1.29e-02 9.69e-01
Negative regulation of FGFR2 signaling 20 9.21e-01 -1.28e-02 9.76e-01
SUMO E3 ligases SUMOylate target proteins 134 8.00e-01 -1.27e-02 9.49e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.23e-01 -1.25e-02 9.76e-01
Downstream signaling of activated FGFR4 18 9.27e-01 1.24e-02 9.76e-01
HCMV Late Events 46 8.88e-01 -1.20e-02 9.70e-01
IRS-related events triggered by IGF1R 33 9.07e-01 -1.18e-02 9.74e-01
TNF signaling 36 9.03e-01 1.17e-02 9.70e-01
Retrograde transport at the Trans-Golgi-Network 43 8.99e-01 -1.11e-02 9.70e-01
S Phase 142 8.21e-01 1.10e-02 9.54e-01
Phospholipid metabolism 162 8.22e-01 1.03e-02 9.54e-01
Autodegradation of Cdh1 by Cdh1:APC/C 58 8.95e-01 -1.00e-02 9.70e-01
Mitotic Prometaphase 141 8.38e-01 -9.99e-03 9.56e-01
Neddylation 201 8.08e-01 -9.99e-03 9.51e-01
Downstream TCR signaling 72 8.84e-01 9.93e-03 9.69e-01
WNT5A-dependent internalization of FZD4 14 9.49e-01 9.89e-03 9.84e-01
Membrane Trafficking 496 7.11e-01 9.83e-03 9.20e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 26 9.31e-01 -9.75e-03 9.79e-01
NoRC negatively regulates rRNA expression 44 9.12e-01 -9.69e-03 9.76e-01
Transport of small molecules 454 7.26e-01 9.69e-03 9.27e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 59 9.03e-01 9.15e-03 9.70e-01
Mitotic Anaphase 173 8.37e-01 9.08e-03 9.56e-01
Mitotic Metaphase and Anaphase 173 8.37e-01 9.08e-03 9.56e-01
Metabolism of RNA 571 7.14e-01 9.06e-03 9.20e-01
MHC class II antigen presentation 73 8.94e-01 9.01e-03 9.70e-01
Metabolism of proteins 1454 5.78e-01 -9.00e-03 8.58e-01
Post-translational protein modification 1035 6.34e-01 8.95e-03 8.88e-01
FCERI mediated NF-kB activation 67 9.01e-01 8.79e-03 9.70e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 9.21e-01 8.79e-03 9.76e-01
p53-Independent DNA Damage Response 43 9.21e-01 8.79e-03 9.76e-01
p53-Independent G1/S DNA damage checkpoint 43 9.21e-01 8.79e-03 9.76e-01
TNFR1-induced NFkappaB signaling pathway 23 9.42e-01 8.69e-03 9.82e-01
Negative regulation of MAPK pathway 39 9.25e-01 -8.68e-03 9.76e-01
Regulation of Apoptosis 45 9.21e-01 -8.60e-03 9.76e-01
G2/M Checkpoints 107 8.79e-01 -8.55e-03 9.69e-01
Assembly and cell surface presentation of NMDA receptors 13 9.58e-01 8.45e-03 9.87e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 28 9.39e-01 8.38e-03 9.82e-01
Gene expression (Transcription) 1022 6.58e-01 8.36e-03 8.93e-01
Platelet Aggregation (Plug Formation) 31 9.40e-01 7.87e-03 9.82e-01
Association of TriC/CCT with target proteins during biosynthesis 35 9.37e-01 7.73e-03 9.82e-01
Degradation of AXIN 47 9.27e-01 7.72e-03 9.76e-01
Metabolism of lipids 543 7.70e-01 -7.43e-03 9.37e-01
Cargo recognition for clathrin-mediated endocytosis 76 9.14e-01 -7.15e-03 9.76e-01
G2/M Transition 154 8.79e-01 7.14e-03 9.69e-01
G-protein beta:gamma signalling 24 9.52e-01 -7.11e-03 9.85e-01
Regulation of TP53 Activity through Methylation 14 9.64e-01 -7.02e-03 9.91e-01
Signaling by RAF1 mutants 38 9.41e-01 -6.96e-03 9.82e-01
Hedgehog 'off' state 87 9.13e-01 -6.79e-03 9.76e-01
PTEN Regulation 130 8.95e-01 6.74e-03 9.70e-01
Acyl chain remodelling of PC 14 9.66e-01 6.62e-03 9.92e-01
ABC-family proteins mediated transport 83 9.17e-01 6.59e-03 9.76e-01
Hedgehog 'on' state 71 9.26e-01 6.36e-03 9.76e-01
MAP kinase activation 60 9.33e-01 -6.31e-03 9.80e-01
mRNA 3'-end processing 51 9.39e-01 -6.23e-03 9.82e-01
Asparagine N-linked glycosylation 241 8.70e-01 6.15e-03 9.65e-01
Long-term potentiation 11 9.73e-01 6.00e-03 9.92e-01
mRNA decay by 5' to 3' exoribonuclease 13 9.70e-01 5.99e-03 9.92e-01
TP53 Regulates Transcription of Cell Death Genes 33 9.55e-01 5.67e-03 9.85e-01
Regulation of TP53 Activity through Acetylation 29 9.58e-01 -5.65e-03 9.87e-01
Signaling by Insulin receptor 52 9.44e-01 -5.64e-03 9.83e-01
Synthesis of PIPs at the early endosome membrane 16 9.71e-01 -5.32e-03 9.92e-01
Negative regulation of FGFR1 signaling 20 9.67e-01 5.32e-03 9.92e-01
Regulation of insulin secretion 52 9.47e-01 5.31e-03 9.84e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 63 9.42e-01 5.30e-03 9.82e-01
Post-translational modification: synthesis of GPI-anchored proteins 41 9.54e-01 -5.20e-03 9.85e-01
Metabolism of polyamines 50 9.50e-01 -5.17e-03 9.84e-01
Aflatoxin activation and detoxification 10 9.78e-01 5.09e-03 9.93e-01
Signaling by FGFR 62 9.48e-01 4.83e-03 9.84e-01
Nucleotide salvage 19 9.71e-01 4.76e-03 9.92e-01
NIK-->noncanonical NF-kB signaling 50 9.54e-01 -4.75e-03 9.85e-01
Recruitment of NuMA to mitotic centrosomes 71 9.46e-01 -4.69e-03 9.83e-01
Signaling by WNT 209 9.19e-01 -4.11e-03 9.76e-01
Rab regulation of trafficking 112 9.42e-01 3.97e-03 9.82e-01
IGF1R signaling cascade 34 9.68e-01 3.95e-03 9.92e-01
PI-3K cascade:FGFR3 10 9.84e-01 -3.73e-03 9.95e-01
Protein-protein interactions at synapses 42 9.68e-01 -3.60e-03 9.92e-01
RNA Polymerase I Promoter Escape 29 9.74e-01 -3.51e-03 9.93e-01
MAP2K and MAPK activation 37 9.72e-01 3.39e-03 9.92e-01
Initiation of Nuclear Envelope (NE) Reformation 16 9.82e-01 -3.26e-03 9.95e-01
Activation of ATR in response to replication stress 28 9.77e-01 -3.13e-03 9.93e-01
RHO GTPases Activate Formins 84 9.64e-01 2.84e-03 9.91e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 29 9.80e-01 2.75e-03 9.94e-01
VEGFR2 mediated cell proliferation 18 9.84e-01 2.66e-03 9.95e-01
Ras activation upon Ca2+ influx through NMDA receptor 13 9.87e-01 -2.59e-03 9.95e-01
Chromatin modifying enzymes 182 9.54e-01 -2.47e-03 9.85e-01
Chromatin organization 182 9.54e-01 -2.47e-03 9.85e-01
Cell Cycle 492 9.35e-01 2.18e-03 9.80e-01
Loss of Nlp from mitotic centrosomes 60 9.77e-01 2.17e-03 9.93e-01
Loss of proteins required for interphase microtubule organization from the centrosome 60 9.77e-01 2.17e-03 9.93e-01
RET signaling 34 9.83e-01 2.11e-03 9.95e-01
Suppression of phagosomal maturation 11 9.91e-01 1.98e-03 9.97e-01
Netrin-1 signaling 39 9.86e-01 1.63e-03 9.95e-01
Synthesis of PIPs at the Golgi membrane 15 9.91e-01 1.60e-03 9.97e-01
EML4 and NUDC in mitotic spindle formation 64 9.84e-01 -1.44e-03 9.95e-01
Signaling by NOTCH4 73 9.87e-01 1.06e-03 9.95e-01
Generic Transcription Pathway 798 9.62e-01 1.01e-03 9.90e-01
PI Metabolism 76 9.89e-01 -9.13e-04 9.96e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 35 9.93e-01 -8.01e-04 9.97e-01
Antigen processing: Ubiquitination & Proteasome degradation 266 9.84e-01 7.04e-04 9.95e-01
Regulation of PTEN gene transcription 59 9.94e-01 -5.59e-04 9.97e-01
RAB GEFs exchange GTP for GDP on RABs 82 9.96e-01 -3.16e-04 9.98e-01
RNA Polymerase II Transcription 910 9.93e-01 -1.77e-04 9.97e-01
Negative regulators of DDX58/IFIH1 signaling 29 9.99e-01 1.74e-04 9.99e-01
SUMOylation of transcription cofactors 39 9.99e-01 -1.67e-04 9.99e-01
SHC-mediated cascade:FGFR4 11 1.00e+00 7.78e-06 1.00e+00



Detailed Gene set reports



Initial triggering of complement

Initial triggering of complement
488
set Initial triggering of complement
setSize 12
pANOVA 1.09e-05
s.dist 0.733
p.adjustANOVA 0.000924



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 5872.0
C1QC 5773.0
CFD 5771.0
C1QB 5471.0
C1R 5262.0
C2 5183.0
C4A 5061.5
C4B 5061.5
GZMM 4962.0
C1QA 4260.0
C1S 4244.0
MASP1 -4292.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 5872.0
C1QC 5773.0
CFD 5771.0
C1QB 5471.0
C1R 5262.0
C2 5183.0
C4A 5061.5
C4B 5061.5
GZMM 4962.0
C1QA 4260.0
C1S 4244.0
MASP1 -4292.0



Signal regulatory protein family interactions

Signal regulatory protein family interactions
993
set Signal regulatory protein family interactions
setSize 13
pANOVA 1.7e-05
s.dist 0.689
p.adjustANOVA 0.00136



Top enriched genes

Top 20 genes
GeneID Gene Rank
SIRPA 5635.5
SIRPB1 5635.5
SIRPG 5635.5
SKAP2 5566.0
TYROBP 5517.0
PTPN6 4679.0
SRC 4543.0
PTK2 4451.0
FYB 4424.0
CD47 2522.0
GRB2 2230.0
PTK2B 1902.0
PTPN11 894.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIRPA 5635.5
SIRPB1 5635.5
SIRPG 5635.5
SKAP2 5566.0
TYROBP 5517.0
PTPN6 4679.0
SRC 4543.0
PTK2 4451.0
FYB 4424.0
CD47 2522.0
GRB2 2230.0
PTK2B 1902.0
PTPN11 894.0



Xenobiotics

Xenobiotics
1236
set Xenobiotics
setSize 14
pANOVA 1.94e-05
s.dist -0.659
p.adjustANOVA 0.00145



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP2D6 -5698.0
CYP2C19 -5670.0
CYP2C8 -5670.0
CYP2C9 -5670.0
CYP3A4 -5039.5
CYP3A43 -5039.5
CYP3A5 -5039.5
CYP3A7 -5039.5
CYP2F1 -4471.0
CYP2E1 -4416.0
CYP2J2 -3037.0
ARNT2 -1033.0
AHR 328.0
ARNT 3024.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP2D6 -5698.0
CYP2C19 -5670.0
CYP2C8 -5670.0
CYP2C9 -5670.0
CYP3A4 -5039.5
CYP3A43 -5039.5
CYP3A5 -5039.5
CYP3A7 -5039.5
CYP2F1 -4471.0
CYP2E1 -4416.0
CYP2J2 -3037.0
ARNT2 -1033.0
AHR 328.0
ARNT 3024.0



Chemokine receptors bind chemokines

Chemokine receptors bind chemokines
163
set Chemokine receptors bind chemokines
setSize 16
pANOVA 0.000248
s.dist 0.529
p.adjustANOVA 0.00991



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCL2 5946.0
CCL7 5932.0
PF4 5905.5
CXCL10 5903.0
CX3CL1 5884.0
CXCL9 5863.0
CCR2 5740.0
ACKR2 5739.0
ACKR3 5487.0
CXCL12 4836.0
CCL11 2949.0
CCL25 1526.0
CXCL16 -1545.0
CXCR4 -2166.0
CCL27 -2599.0
CCL5 -4320.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL2 5946.0
CCL7 5932.0
PF4 5905.5
CXCL10 5903.0
CX3CL1 5884.0
CXCL9 5863.0
CCR2 5740.0
ACKR2 5739.0
ACKR3 5487.0
CXCL12 4836.0
CCL11 2949.0
CCL25 1526.0
CXCL16 -1545.0
CXCR4 -2166.0
CCL27 -2599.0
CCL5 -4320.0



RIP-mediated NFkB activation via ZBP1

RIP-mediated NFkB activation via ZBP1
823
set RIP-mediated NFkB activation via ZBP1
setSize 17
pANOVA 0.000163
s.dist 0.528
p.adjustANOVA 0.00715



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZBP1 5801
RELA 5784
NKIRAS2 5273
RIPK3 4623
NFKBIB 4525
CHUK 4512
NFKB2 4366
TLR3 4102
MYD88 4061
IKBKG 4052
NFKB1 2930
DHX9 2680
TICAM1 2510
NFKBIA 2079
IKBKB 679
RIPK1 -797
NKIRAS1 -3002

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZBP1 5801
RELA 5784
NKIRAS2 5273
RIPK3 4623
NFKBIB 4525
CHUK 4512
NFKB2 4366
TLR3 4102
MYD88 4061
IKBKG 4052
NFKB1 2930
DHX9 2680
TICAM1 2510
NFKBIA 2079
IKBKB 679
RIPK1 -797
NKIRAS1 -3002



Plasma lipoprotein assembly

Plasma lipoprotein assembly
757
set Plasma lipoprotein assembly
setSize 15
pANOVA 0.000708
s.dist -0.505
p.adjustANOVA 0.0203



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOE -5741.0
MTTP -5613.0
APOB -5284.0
APOC4 -5090.5
APOC3 -5026.0
APOA2 -4650.0
APOC1 -4547.0
PRKACA -3281.0
APOA1 -3195.0
PRKACB -2638.0
SAR1B -1875.0
BMP1 -1273.0
ABCA1 129.0
P4HB 394.0
ZDHHC8 4987.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOE -5741.0
MTTP -5613.0
APOB -5284.0
APOC4 -5090.5
APOC3 -5026.0
APOA2 -4650.0
APOC1 -4547.0
PRKACA -3281.0
APOA1 -3195.0
PRKACB -2638.0
SAR1B -1875.0
BMP1 -1273.0
ABCA1 129.0
P4HB 394.0
ZDHHC8 4987.0



Interleukin-4 and Interleukin-13 signaling

Interleukin-4 and Interleukin-13 signaling
519
set Interleukin-4 and Interleukin-13 signaling
setSize 73
pANOVA 1.79e-13
s.dist 0.499
p.adjustANOVA 1.14e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCL2 5946
CDKN1A 5945
JUNB 5943
MMP3 5927
SOCS3 5907
HMOX1 5883
F13A1 5867
IL4R 5861
MMP9 5837
FOS 5811
ANXA1 5796
LBP 5772
TWIST1 5744
ALOX5 5693
TIMP1 5648
TP53 5559
RHOU 5547
ITGB2 5540
STAT3 5528
JAK3 5515

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL2 5946
CDKN1A 5945
JUNB 5943
MMP3 5927
SOCS3 5907
HMOX1 5883
F13A1 5867
IL4R 5861
MMP9 5837
FOS 5811
ANXA1 5796
LBP 5772
TWIST1 5744
ALOX5 5693
TIMP1 5648
TP53 5559
RHOU 5547
ITGB2 5540
STAT3 5528
JAK3 5515
MYC 5424
IL6R 5406
VIM 5386
RORC 5383
CCND1 5282
TNFRSF1B 5186
SOCS1 5145
HSP90AA1 5130
NDN 4998
ITGAM 4960
TGFB1 4845
IRF4 4832
NOS2 4633
AKT1 4605
ICAM1 4520
S1PR1 4402
HSPA8 4320
FOXO3 4136
SOCS5 4107
MMP2 3896
IL2RG 3873
IL13RA1 3816
ZEB1 3449
LCN2 3232
COL1A2 3027
CCL11 2949
ITGAX 2876
FN1 2783
LAMA5 2111
ITGB1 1955
VCAM1 1893
VEGFA 1839
HIF1A 1574
POU2F1 1301
FSCN1 1242
MCL1 821
HSP90B1 352
FOXO1 64
JAK1 58
PIM1 5
CD36 -91
TYK2 -218
STAT6 -226
BCL2 -1125
FGF2 -1726
STAT1 -1769
BCL6 -1820
JAK2 -3123
RORA -3629
BCL2L1 -3915
MAOA -4623
IL12A -4707
PIK3R1 -5134



Cristae formation

Cristae formation
202
set Cristae formation
setSize 10
pANOVA 0.00729
s.dist -0.49
p.adjustANOVA 0.0968



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOOL -5506
MTX1 -5332
TMEM11 -3938
MTX2 -3852
IMMT -3163
SAMM50 -1835
HSPA9 -1728
CHCHD3 -1326
CHCHD6 -1170
DNAJC11 245

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOOL -5506
MTX1 -5332
TMEM11 -3938
MTX2 -3852
IMMT -3163
SAMM50 -1835
HSPA9 -1728
CHCHD3 -1326
CHCHD6 -1170
DNAJC11 245



Cell recruitment (pro-inflammatory response)

Cell recruitment (pro-inflammatory response)
150
set Cell recruitment (pro-inflammatory response)
setSize 17
pANOVA 0.000508
s.dist 0.487
p.adjustANOVA 0.0162



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 5872
RELA 5784
CASP1 5720
C3AR1 5208
ENTPD1 4784
TXN 4603
P2RX4 4534
NFKB2 4366
HSP90AB1 4205
NT5E 3812
PSTPIP1 3682
NFKB1 2930
ENTPD5 1384
TXNIP -44
P2RX7 -795
PYCARD -2713
SUGT1 -3242

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 5872
RELA 5784
CASP1 5720
C3AR1 5208
ENTPD1 4784
TXN 4603
P2RX4 4534
NFKB2 4366
HSP90AB1 4205
NT5E 3812
PSTPIP1 3682
NFKB1 2930
ENTPD5 1384
TXNIP -44
P2RX7 -795
PYCARD -2713
SUGT1 -3242



Purinergic signaling in leishmaniasis infection

Purinergic signaling in leishmaniasis infection
803
set Purinergic signaling in leishmaniasis infection
setSize 17
pANOVA 0.000508
s.dist 0.487
p.adjustANOVA 0.0162



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 5872
RELA 5784
CASP1 5720
C3AR1 5208
ENTPD1 4784
TXN 4603
P2RX4 4534
NFKB2 4366
HSP90AB1 4205
NT5E 3812
PSTPIP1 3682
NFKB1 2930
ENTPD5 1384
TXNIP -44
P2RX7 -795
PYCARD -2713
SUGT1 -3242

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 5872
RELA 5784
CASP1 5720
C3AR1 5208
ENTPD1 4784
TXN 4603
P2RX4 4534
NFKB2 4366
HSP90AB1 4205
NT5E 3812
PSTPIP1 3682
NFKB1 2930
ENTPD5 1384
TXNIP -44
P2RX7 -795
PYCARD -2713
SUGT1 -3242



Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases
41
set Activation of Matrix Metalloproteinases
setSize 15
pANOVA 0.00219
s.dist 0.457
p.adjustANOVA 0.0432



Top enriched genes

Top 20 genes
GeneID Gene Rank
MMP3 5927
MMP9 5837
TPSAB1 5823
CMA1 5697
TIMP1 5648
TIMP2 4343
MMP15 4155
MMP2 3896
MMP14 2542
MMP11 2306
COL18A1 1804
CTSV 1798
FURIN -636
CTSK -1841
PLG -5740

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMP3 5927
MMP9 5837
TPSAB1 5823
CMA1 5697
TIMP1 5648
TIMP2 4343
MMP15 4155
MMP2 3896
MMP14 2542
MMP11 2306
COL18A1 1804
CTSV 1798
FURIN -636
CTSK -1841
PLG -5740



Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation
44
set Activation of PPARGC1A (PGC-1alpha) by phosphorylation
setSize 10
pANOVA 0.0137
s.dist -0.45
p.adjustANOVA 0.142



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAG3 -5691
MAPK12 -5052
MAPK11 -3856
PPARGC1A -2915
PRKAG1 -2841
PRKAB2 -2446
PRKAB1 -1625
PRKAA2 -1561
MAPK14 -52
PRKAG2 754

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAG3 -5691
MAPK12 -5052
MAPK11 -3856
PPARGC1A -2915
PRKAG1 -2841
PRKAB2 -2446
PRKAB1 -1625
PRKAA2 -1561
MAPK14 -52
PRKAG2 754



The NLRP3 inflammasome

The NLRP3 inflammasome
1140
set The NLRP3 inflammasome
setSize 13
pANOVA 0.00606
s.dist 0.44
p.adjustANOVA 0.083



Top enriched genes

Top 20 genes
GeneID Gene Rank
RELA 5784
CASP1 5720
APP 5448
PANX1 4772
TXN 4603
NFKB2 4366
HSP90AB1 4205
PSTPIP1 3682
NFKB1 2930
TXNIP -44
P2RX7 -795
PYCARD -2713
SUGT1 -3242

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELA 5784
CASP1 5720
APP 5448
PANX1 4772
TXN 4603
NFKB2 4366
HSP90AB1 4205
PSTPIP1 3682
NFKB1 2930
TXNIP -44
P2RX7 -795
PYCARD -2713
SUGT1 -3242



Interleukin-10 signaling

Interleukin-10 signaling
510
set Interleukin-10 signaling
setSize 19
pANOVA 0.000914
s.dist 0.439
p.adjustANOVA 0.0248



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCL2 5946.0
CXCL10 5903.0
CSF1 5893.0
IL1R2 5886.0
TNFRSF1A 5840.0
CCR2 5740.0
PTAFR 5706.0
TIMP1 5648.0
STAT3 5528.0
TNFRSF1B 5186.0
ICAM1 4520.0
IL10RB 1095.5
IL1R1 512.0
JAK1 58.0
TYK2 -218.0
IL10RA -262.0
CD86 -3262.0
CCL5 -4320.0
IL12A -4707.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL2 5946.0
CXCL10 5903.0
CSF1 5893.0
IL1R2 5886.0
TNFRSF1A 5840.0
CCR2 5740.0
PTAFR 5706.0
TIMP1 5648.0
STAT3 5528.0
TNFRSF1B 5186.0
ICAM1 4520.0
IL10RB 1095.5
IL1R1 512.0
JAK1 58.0
TYK2 -218.0
IL10RA -262.0
CD86 -3262.0
CCL5 -4320.0
IL12A -4707.0



Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade
267
set Diseases associated with the TLR signaling cascade
setSize 19
pANOVA 0.00114
s.dist 0.431
p.adjustANOVA 0.0268



Top enriched genes

Top 20 genes
GeneID Gene Rank
RELA 5784
TLR4 5524
TLR5 4900
CHUK 4512
NFKB2 4366
TIRAP 4206
TLR3 4102
MYD88 4061
IKBKG 4052
TRAF3 3627
NFKB1 2930
TICAM1 2510
NFKBIA 2079
IKBKB 679
CD14 591
CD36 -91
IRAK4 -243
TLR6 -1411
TLR2 -2388

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELA 5784
TLR4 5524
TLR5 4900
CHUK 4512
NFKB2 4366
TIRAP 4206
TLR3 4102
MYD88 4061
IKBKG 4052
TRAF3 3627
NFKB1 2930
TICAM1 2510
NFKBIA 2079
IKBKB 679
CD14 591
CD36 -91
IRAK4 -243
TLR6 -1411
TLR2 -2388



Diseases of Immune System

Diseases of Immune System
268
set Diseases of Immune System
setSize 19
pANOVA 0.00114
s.dist 0.431
p.adjustANOVA 0.0268



Top enriched genes

Top 20 genes
GeneID Gene Rank
RELA 5784
TLR4 5524
TLR5 4900
CHUK 4512
NFKB2 4366
TIRAP 4206
TLR3 4102
MYD88 4061
IKBKG 4052
TRAF3 3627
NFKB1 2930
TICAM1 2510
NFKBIA 2079
IKBKB 679
CD14 591
CD36 -91
IRAK4 -243
TLR6 -1411
TLR2 -2388

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELA 5784
TLR4 5524
TLR5 4900
CHUK 4512
NFKB2 4366
TIRAP 4206
TLR3 4102
MYD88 4061
IKBKG 4052
TRAF3 3627
NFKB1 2930
TICAM1 2510
NFKBIA 2079
IKBKB 679
CD14 591
CD36 -91
IRAK4 -243
TLR6 -1411
TLR2 -2388



Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Formation of Senescence-Associated Heterochromatin Foci (SAHF)
357
set Formation of Senescence-Associated Heterochromatin Foci (SAHF)
setSize 10
pANOVA 0.0185
s.dist 0.43
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1A 5945
HMGA1 5663
TP53 5559
RB1 4884
UBN1 3590
CABIN1 2781
LMNB1 694
ASF1A 598
EP400 -829
HIRA -2718

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1A 5945
HMGA1 5663
TP53 5559
RB1 4884
UBN1 3590
CABIN1 2781
LMNB1 694
ASF1A 598
EP400 -829
HIRA -2718



ZBP1(DAI) mediated induction of type I IFNs

ZBP1(DAI) mediated induction of type I IFNs
1238
set ZBP1(DAI) mediated induction of type I IFNs
setSize 20
pANOVA 0.001
s.dist 0.425
p.adjustANOVA 0.0258



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZBP1 5801
RELA 5784
NKIRAS2 5273
RIPK3 4623
NFKBIB 4525
CHUK 4512
NFKB2 4366
TLR3 4102
MYD88 4061
IKBKG 4052
TBK1 3279
NFKB1 2930
DHX9 2680
TICAM1 2510
NFKBIA 2079
IKBKB 679
DTX4 -630
RIPK1 -797
NKIRAS1 -3002
IRF3 -5162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZBP1 5801
RELA 5784
NKIRAS2 5273
RIPK3 4623
NFKBIB 4525
CHUK 4512
NFKB2 4366
TLR3 4102
MYD88 4061
IKBKG 4052
TBK1 3279
NFKB1 2930
DHX9 2680
TICAM1 2510
NFKBIA 2079
IKBKB 679
DTX4 -630
RIPK1 -797
NKIRAS1 -3002
IRF3 -5162



Defective B4GALT7 causes EDS, progeroid type

Defective B4GALT7 causes EDS, progeroid type
237
set Defective B4GALT7 causes EDS, progeroid type
setSize 15
pANOVA 0.0048
s.dist 0.421
p.adjustANOVA 0.0711



Top enriched genes

Top 20 genes
GeneID Gene Rank
VCAN 5645
BGN 5425
SDC4 5232
SDC3 5177
DCN 5146
GPC6 4666
HSPG2 4308
GPC4 3765
B4GALT7 1806
GPC1 1506
GPC3 1179
SDC1 -148
CSPG4 -383
SDC2 -2418
AGRN -2522

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VCAN 5645
BGN 5425
SDC4 5232
SDC3 5177
DCN 5146
GPC6 4666
HSPG2 4308
GPC4 3765
B4GALT7 1806
GPC1 1506
GPC3 1179
SDC1 -148
CSPG4 -383
SDC2 -2418
AGRN -2522



Interleukin-37 signaling

Interleukin-37 signaling
518
set Interleukin-37 signaling
setSize 17
pANOVA 0.00292
s.dist 0.417
p.adjustANOVA 0.0509



Top enriched genes

Top 20 genes
GeneID Gene Rank
CASP1 5720
IL18BP 5677
STAT3 5528
PTPN7 5494
PTPN14 5020
PTPN6 4679
PTPN12 3420
TBK1 3279
PTPN23 3266
PTPN9 1505
PTPN13 1416
PTPN18 1135
SIGIRR 1080
PTPN11 894
PTPN4 -168
SMAD3 -1322
PTPN2 -3485

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP1 5720
IL18BP 5677
STAT3 5528
PTPN7 5494
PTPN14 5020
PTPN6 4679
PTPN12 3420
TBK1 3279
PTPN23 3266
PTPN9 1505
PTPN13 1416
PTPN18 1135
SIGIRR 1080
PTPN11 894
PTPN4 -168
SMAD3 -1322
PTPN2 -3485



PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair
716
set PCNA-Dependent Long Patch Base Excision Repair
setSize 19
pANOVA 0.00202
s.dist -0.409
p.adjustANOVA 0.0422



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLE3 -5374
RFC1 -5119
RFC3 -4978
RPA2 -4884
RFC4 -4574
POLD4 -4088
RPA3 -3737
RPA1 -3597
RFC5 -2851
POLE4 -2203
POLB -1553
POLD3 -1469
RFC2 -1083
PCNA -971
POLE -140
APEX1 -128
POLD2 715
LIG1 904
POLD1 1697

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLE3 -5374
RFC1 -5119
RFC3 -4978
RPA2 -4884
RFC4 -4574
POLD4 -4088
RPA3 -3737
RPA1 -3597
RFC5 -2851
POLE4 -2203
POLB -1553
POLD3 -1469
RFC2 -1083
PCNA -971
POLE -140
APEX1 -128
POLD2 715
LIG1 904
POLD1 1697



Translesion synthesis by REV1

Translesion synthesis by REV1
1188
set Translesion synthesis by REV1
setSize 14
pANOVA 0.00816
s.dist -0.408
p.adjustANOVA 0.104



Top enriched genes

Top 20 genes
GeneID Gene Rank
RFC1 -5119
RFC3 -4978
RPA2 -4884
REV3L -4795
RFC4 -4574
UBC -4096
RPA3 -3737
RPA1 -3597
RFC5 -2851
RFC2 -1083
PCNA -971
REV1 2051
MAD2L2 2385
RPS27A 4294

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RFC1 -5119
RFC3 -4978
RPA2 -4884
REV3L -4795
RFC4 -4574
UBC -4096
RPA3 -3737
RPA1 -3597
RFC5 -2851
RFC2 -1083
PCNA -971
REV1 2051
MAD2L2 2385
RPS27A 4294



Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC
68
set Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize 17
pANOVA 0.00485
s.dist 0.395
p.adjustANOVA 0.0711



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAP2 5902
PDIA3 5391
TAP1 5376
B2M 5335
TAPBP 4936
SEC31A 4699
HSPA5 4665
SEC24D 4398
SEC24C 3758
CALR 2782
CANX 1251
SEC13 955
SEC24B 302
SEC23A -114
SAR1B -1875
ERAP1 -2285
SEC24A -4559

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAP2 5902
PDIA3 5391
TAP1 5376
B2M 5335
TAPBP 4936
SEC31A 4699
HSPA5 4665
SEC24D 4398
SEC24C 3758
CALR 2782
CANX 1251
SEC13 955
SEC24B 302
SEC23A -114
SAR1B -1875
ERAP1 -2285
SEC24A -4559



Synthesis of IP2, IP, and Ins in the cytosol

Synthesis of IP2, IP, and Ins in the cytosol
1086
set Synthesis of IP2, IP, and Ins in the cytosol
setSize 12
pANOVA 0.0184
s.dist 0.393
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTMR9 5692
INPP5A 5582
SYNJ1 4886
IMPA2 3818
INPP5B 3434
INPP5J 3138
ISYNA1 2463
INPP1 1709
INPP4B 1166
INPP4A 121
IMPA1 -13
OCRL -3216

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTMR9 5692
INPP5A 5582
SYNJ1 4886
IMPA2 3818
INPP5B 3434
INPP5J 3138
ISYNA1 2463
INPP1 1709
INPP4B 1166
INPP4A 121
IMPA1 -13
OCRL -3216



Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
605
set Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
setSize 13
pANOVA 0.0148
s.dist -0.391
p.adjustANOVA 0.145



Top enriched genes

Top 20 genes
GeneID Gene Rank
MLH1 -5562
RPA2 -4884
MSH3 -4253
POLD4 -4088
RPA3 -3737
RPA1 -3597
PMS2 -2900
POLD3 -1469
PCNA -971
MSH2 -183
POLD2 715
LIG1 904
POLD1 1697

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MLH1 -5562
RPA2 -4884
MSH3 -4253
POLD4 -4088
RPA3 -3737
RPA1 -3597
PMS2 -2900
POLD3 -1469
PCNA -971
MSH2 -183
POLD2 715
LIG1 904
POLD1 1697



FCGR activation

FCGR activation
331
set FCGR activation
setSize 10
pANOVA 0.0325
s.dist 0.39
p.adjustANOVA 0.231



Top enriched genes

Top 20 genes
GeneID Gene Rank
FYN 5329.0
FCGR1A 5223.5
FCGR2A 5002.5
SRC 4543.0
FGR 3790.0
YES1 3560.0
HCK 2214.0
SYK 77.0
CD247 -2385.0
LYN -3519.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN 5329.0
FCGR1A 5223.5
FCGR2A 5002.5
SRC 4543.0
FGR 3790.0
YES1 3560.0
HCK 2214.0
SYK 77.0
CD247 -2385.0
LYN -3519.0



Post-chaperonin tubulin folding pathway

Post-chaperonin tubulin folding pathway
771
set Post-chaperonin tubulin folding pathway
setSize 15
pANOVA 0.00929
s.dist 0.388
p.adjustANOVA 0.113



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB6 5939
TUBB4B 5849
TUBB2A 5349
TUBB4A 4765
TUBA4A 4655
TUBA8 4438
TUBA1A 4218
TBCD 2605
TUBA1C 1634
TBCA 976
TUBA1B 471
TBCE 285
TBCC 140
TBCB -2704
ARL2 -3098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB6 5939
TUBB4B 5849
TUBB2A 5349
TUBB4A 4765
TUBA4A 4655
TUBA8 4438
TUBA1A 4218
TBCD 2605
TUBA1C 1634
TBCA 976
TUBA1B 471
TBCE 285
TBCC 140
TBCB -2704
ARL2 -3098



Adenylate cyclase inhibitory pathway

Adenylate cyclase inhibitory pathway
56
set Adenylate cyclase inhibitory pathway
setSize 12
pANOVA 0.0219
s.dist 0.382
p.adjustANOVA 0.18



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADCY9 5618
GNAI2 5184
ADCY6 4753
GNAI1 4264
ADCY1 3962
ADCY3 3318
GNAI3 2947
GNAL 1503
ADCY7 470
ADCY5 -694
ADCY4 -922
ADCY2 -2376

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADCY9 5618
GNAI2 5184
ADCY6 4753
GNAI1 4264
ADCY1 3962
ADCY3 3318
GNAI3 2947
GNAL 1503
ADCY7 470
ADCY5 -694
ADCY4 -922
ADCY2 -2376



Translesion synthesis by POLI

Translesion synthesis by POLI
1186
set Translesion synthesis by POLI
setSize 15
pANOVA 0.0107
s.dist -0.381
p.adjustANOVA 0.124



Top enriched genes

Top 20 genes
GeneID Gene Rank
RFC1 -5119
RFC3 -4978
RPA2 -4884
REV3L -4795
RFC4 -4574
UBC -4096
RPA3 -3737
RPA1 -3597
RFC5 -2851
RFC2 -1083
PCNA -971
POLI 138
REV1 2051
MAD2L2 2385
RPS27A 4294

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RFC1 -5119
RFC3 -4978
RPA2 -4884
REV3L -4795
RFC4 -4574
UBC -4096
RPA3 -3737
RPA1 -3597
RFC5 -2851
RFC2 -1083
PCNA -971
POLI 138
REV1 2051
MAD2L2 2385
RPS27A 4294



Mitochondrial tRNA aminoacylation

Mitochondrial tRNA aminoacylation
613
set Mitochondrial tRNA aminoacylation
setSize 18
pANOVA 0.00528
s.dist -0.38
p.adjustANOVA 0.0756



Top enriched genes

Top 20 genes
GeneID Gene Rank
TARS2 -5335.0
SARS2 -4530.5
DARS2 -4403.0
NARS2 -4375.0
IARS2 -3817.0
HARS2 -2665.0
AARS2 -2485.0
YARS2 -2470.0
FARS2 -2335.0
VARS2 -2004.0
WARS2 -1922.0
LARS2 -1897.0
PPA2 -1628.0
RARS2 -1230.0
CARS2 -625.0
MARS2 -9.0
EARS2 385.0
PARS2 3274.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TARS2 -5335.0
SARS2 -4530.5
DARS2 -4403.0
NARS2 -4375.0
IARS2 -3817.0
HARS2 -2665.0
AARS2 -2485.0
YARS2 -2470.0
FARS2 -2335.0
VARS2 -2004.0
WARS2 -1922.0
LARS2 -1897.0
PPA2 -1628.0
RARS2 -1230.0
CARS2 -625.0
MARS2 -9.0
EARS2 385.0
PARS2 3274.0



Defective B3GAT3 causes JDSSDHD

Defective B3GAT3 causes JDSSDHD
236
set Defective B3GAT3 causes JDSSDHD
setSize 15
pANOVA 0.0109
s.dist 0.38
p.adjustANOVA 0.125



Top enriched genes

Top 20 genes
GeneID Gene Rank
VCAN 5645
BGN 5425
SDC4 5232
SDC3 5177
DCN 5146
GPC6 4666
HSPG2 4308
GPC4 3765
GPC1 1506
GPC3 1179
SDC1 -148
CSPG4 -383
B3GAT3 -1773
SDC2 -2418
AGRN -2522

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VCAN 5645
BGN 5425
SDC4 5232
SDC3 5177
DCN 5146
GPC6 4666
HSPG2 4308
GPC4 3765
GPC1 1506
GPC3 1179
SDC1 -148
CSPG4 -383
B3GAT3 -1773
SDC2 -2418
AGRN -2522



Cell-extracellular matrix interactions

Cell-extracellular matrix interactions
154
set Cell-extracellular matrix interactions
setSize 15
pANOVA 0.011
s.dist 0.379
p.adjustANOVA 0.125



Top enriched genes

Top 20 genes
GeneID Gene Rank
FLNC 5737.0
LIMS2 5169.0
TESK1 4909.0
ACTN1 4787.0
LIMS1 3223.5
PXN 2340.0
PARVB 2319.0
VASP 2202.0
RSU1 2027.0
ITGB1 1955.0
PARVA 1774.0
FERMT2 950.0
FBLIM1 654.0
FLNA -453.0
ARHGEF6 -2819.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FLNC 5737.0
LIMS2 5169.0
TESK1 4909.0
ACTN1 4787.0
LIMS1 3223.5
PXN 2340.0
PARVB 2319.0
VASP 2202.0
RSU1 2027.0
ITGB1 1955.0
PARVA 1774.0
FERMT2 950.0
FBLIM1 654.0
FLNA -453.0
ARHGEF6 -2819.0



Regulation of Complement cascade

Regulation of Complement cascade
876
set Regulation of Complement cascade
setSize 24
pANOVA 0.0013
s.dist 0.379
p.adjustANOVA 0.029



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 5872.0
SERPING1 5826.0
C7 5809.0
C1QC 5773.0
C5AR1 5643.0
C1QB 5471.0
C1R 5262.0
C3AR1 5208.0
C2 5183.0
C4A 5061.5
C4B 5061.5
CFH 5012.0
C1QA 4260.0
C1S 4244.0
CD59 4236.0
PROS1 3026.0
CD81 421.0
CR1 196.5
CD46 -647.0
CLU -2903.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 5872.0
SERPING1 5826.0
C7 5809.0
C1QC 5773.0
C5AR1 5643.0
C1QB 5471.0
C1R 5262.0
C3AR1 5208.0
C2 5183.0
C4A 5061.5
C4B 5061.5
CFH 5012.0
C1QA 4260.0
C1S 4244.0
CD59 4236.0
PROS1 3026.0
CD81 421.0
CR1 196.5
CD46 -647.0
CLU -2903.0
CD55 -5486.0
VTN -5595.0
C8G -5641.0
F2 -5707.0



Removal of the Flap Intermediate from the C-strand

Removal of the Flap Intermediate from the C-strand
921
set Removal of the Flap Intermediate from the C-strand
setSize 16
pANOVA 0.00866
s.dist -0.379
p.adjustANOVA 0.108



Top enriched genes

Top 20 genes
GeneID Gene Rank
WRN -5410
TERF1 -5308
RPA2 -4884
POT1 -4685
POLD4 -4088
TINF2 -4078
TERF2 -3831
RPA3 -3737
RPA1 -3597
TERF2IP -2551
POLD3 -1469
PCNA -971
POLD2 715
POLD1 1697
DNA2 3285
ACD 5127

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WRN -5410
TERF1 -5308
RPA2 -4884
POT1 -4685
POLD4 -4088
TINF2 -4078
TERF2 -3831
RPA3 -3737
RPA1 -3597
TERF2IP -2551
POLD3 -1469
PCNA -971
POLD2 715
POLD1 1697
DNA2 3285
ACD 5127



Striated Muscle Contraction

Striated Muscle Contraction
1077
set Striated Muscle Contraction
setSize 31
pANOVA 0.000267
s.dist -0.378
p.adjustANOVA 0.01



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYH8 -5589
TMOD4 -5523
TNNI1 -5424
TNNT2 -5326
MYL4 -5217
TPM1 -5216
TPM2 -5163
MYL1 -5115
TNNI2 -5006
MYBPC2 -4972
TNNT3 -4917
TNNC2 -4861
TNNT1 -4853
TCAP -4545
MYH6 -3989
MYBPC1 -3929
TNNC1 -3794
MYH3 -3493
DMD -2606
MYL3 -1989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYH8 -5589
TMOD4 -5523
TNNI1 -5424
TNNT2 -5326
MYL4 -5217
TPM1 -5216
TPM2 -5163
MYL1 -5115
TNNI2 -5006
MYBPC2 -4972
TNNT3 -4917
TNNC2 -4861
TNNT1 -4853
TCAP -4545
MYH6 -3989
MYBPC1 -3929
TNNC1 -3794
MYH3 -3493
DMD -2606
MYL3 -1989
TTN -1612
ACTN2 -868
NEB -141
TMOD3 450
DES 1263
TMOD1 2476
TMOD2 3495
TPM3 4929
TPM4 5008
VIM 5386
MYL2 5909



Complement cascade

Complement cascade
187
set Complement cascade
setSize 27
pANOVA 0.000718
s.dist 0.376
p.adjustANOVA 0.0203



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 5872.0
SERPING1 5826.0
C7 5809.0
C1QC 5773.0
CFD 5771.0
C5AR1 5643.0
C1QB 5471.0
C1R 5262.0
C3AR1 5208.0
C2 5183.0
C4A 5061.5
C4B 5061.5
CFH 5012.0
GZMM 4962.0
C1QA 4260.0
C1S 4244.0
CD59 4236.0
PROS1 3026.0
CD81 421.0
CR1 196.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 5872.0
SERPING1 5826.0
C7 5809.0
C1QC 5773.0
CFD 5771.0
C5AR1 5643.0
C1QB 5471.0
C1R 5262.0
C3AR1 5208.0
C2 5183.0
C4A 5061.5
C4B 5061.5
CFH 5012.0
GZMM 4962.0
C1QA 4260.0
C1S 4244.0
CD59 4236.0
PROS1 3026.0
CD81 421.0
CR1 196.5
CD46 -647.0
CLU -2903.0
MASP1 -4292.0
CD55 -5486.0
VTN -5595.0
C8G -5641.0
F2 -5707.0



Interleukin-15 signaling

Interleukin-15 signaling
513
set Interleukin-15 signaling
setSize 13
pANOVA 0.0207
s.dist 0.371
p.adjustANOVA 0.173



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT3 5528
JAK3 5515
GAB2 3981
IL2RG 3873
SHC1 3146
STAT5B 2521
STAT5A 2347
GRB2 2230
SOS2 1704
IL15 889
JAK1 58
SOS1 -567
IL15RA -1760

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT3 5528
JAK3 5515
GAB2 3981
IL2RG 3873
SHC1 3146
STAT5B 2521
STAT5A 2347
GRB2 2230
SOS2 1704
IL15 889
JAK1 58
SOS1 -567
IL15RA -1760



Defective B3GALT6 causes EDSP2 and SEMDJL1

Defective B3GALT6 causes EDSP2 and SEMDJL1
234
set Defective B3GALT6 causes EDSP2 and SEMDJL1
setSize 15
pANOVA 0.0137
s.dist 0.368
p.adjustANOVA 0.142



Top enriched genes

Top 20 genes
GeneID Gene Rank
VCAN 5645
BGN 5425
SDC4 5232
SDC3 5177
DCN 5146
GPC6 4666
HSPG2 4308
GPC4 3765
GPC1 1506
GPC3 1179
SDC1 -148
CSPG4 -383
SDC2 -2418
AGRN -2522
B3GALT6 -2830

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VCAN 5645
BGN 5425
SDC4 5232
SDC3 5177
DCN 5146
GPC6 4666
HSPG2 4308
GPC4 3765
GPC1 1506
GPC3 1179
SDC1 -148
CSPG4 -383
SDC2 -2418
AGRN -2522
B3GALT6 -2830



Mitochondrial calcium ion transport

Mitochondrial calcium ion transport
610
set Mitochondrial calcium ion transport
setSize 21
pANOVA 0.00374
s.dist -0.366
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
VDAC3 -5383
MICU3 -5175
MCU -4906
PMPCB -4689
PHB -4218
STOML2 -3536
SLC8A3 -3101
VDAC2 -2905
SMDT1 -2701
YME1L1 -2431
VDAC1 -2323
MICU1 -2236
LETM1 -2183
SPG7 -1778
PARL -1667
MICU2 -1229
C2orf47 -543
AFG3L2 -162
PMPCA 1841
AKAP1 3228

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VDAC3 -5383
MICU3 -5175
MCU -4906
PMPCB -4689
PHB -4218
STOML2 -3536
SLC8A3 -3101
VDAC2 -2905
SMDT1 -2701
YME1L1 -2431
VDAC1 -2323
MICU1 -2236
LETM1 -2183
SPG7 -1778
PARL -1667
MICU2 -1229
C2orf47 -543
AFG3L2 -162
PMPCA 1841
AKAP1 3228
PHB2 3448



Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
924
set Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize 22
pANOVA 0.0033
s.dist -0.362
p.adjustANOVA 0.0546



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLE3 -5374
RFC1 -5119
PARP2 -5034
RFC3 -4978
RPA2 -4884
RFC4 -4574
POLD4 -4088
RPA3 -3737
RPA1 -3597
RFC5 -2851
POLE4 -2203
POLB -1553
POLD3 -1469
RFC2 -1083
PCNA -971
POLE -140
APEX1 -128
POLD2 715
LIG1 904
PARP1 1572

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLE3 -5374
RFC1 -5119
PARP2 -5034
RFC3 -4978
RPA2 -4884
RFC4 -4574
POLD4 -4088
RPA3 -3737
RPA1 -3597
RFC5 -2851
POLE4 -2203
POLB -1553
POLD3 -1469
RFC2 -1083
PCNA -971
POLE -140
APEX1 -128
POLD2 715
LIG1 904
PARP1 1572
POLD1 1697
PARG 2674



Processing of SMDT1

Processing of SMDT1
788
set Processing of SMDT1
setSize 15
pANOVA 0.0158
s.dist -0.36
p.adjustANOVA 0.149



Top enriched genes

Top 20 genes
GeneID Gene Rank
MICU3 -5175
MCU -4906
PMPCB -4689
PHB -4218
STOML2 -3536
SMDT1 -2701
YME1L1 -2431
MICU1 -2236
SPG7 -1778
PARL -1667
MICU2 -1229
C2orf47 -543
AFG3L2 -162
PMPCA 1841
PHB2 3448

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MICU3 -5175
MCU -4906
PMPCB -4689
PHB -4218
STOML2 -3536
SMDT1 -2701
YME1L1 -2431
MICU1 -2236
SPG7 -1778
PARL -1667
MICU2 -1229
C2orf47 -543
AFG3L2 -162
PMPCA 1841
PHB2 3448



Mitochondrial protein import

Mitochondrial protein import
612
set Mitochondrial protein import
setSize 56
pANOVA 3.49e-06
s.dist -0.359
p.adjustANOVA 0.000405



Top enriched genes

Top 20 genes
GeneID Gene Rank
TIMM9 -5574
TIMM44 -5432
TAZ -5344
MTX1 -5332
COX19 -5190
CHCHD2 -4913
TIMM17B -4693
PMPCB -4689
DNAJC19 -4634
GRPEL2 -4602
COX17 -4594
TIMM22 -4528
NDUFB8 -4491
CMC2 -4432
TIMM13 -4355
TIMM17A -4108
TIMM50 -3954
TIMM21 -3884
MTX2 -3852
SLC25A4 -3773

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TIMM9 -5574.0
TIMM44 -5432.0
TAZ -5344.0
MTX1 -5332.0
COX19 -5190.0
CHCHD2 -4913.0
TIMM17B -4693.0
PMPCB -4689.0
DNAJC19 -4634.0
GRPEL2 -4602.0
COX17 -4594.0
TIMM22 -4528.0
NDUFB8 -4491.0
CMC2 -4432.0
TIMM13 -4355.0
TIMM17A -4108.0
TIMM50 -3954.0
TIMM21 -3884.0
MTX2 -3852.0
SLC25A4 -3773.0
IDH3G -3771.0
FXN -3600.0
TIMM10B -3522.0
TOMM40 -3362.0
TOMM22 -2562.0
CYC1 -2530.0
SLC25A12 -2390.0
CHCHD7 -2359.0
VDAC1 -2323.0
COA4 -2147.0
LDHD -2119.0
TIMM10 -1993.0
SAMM50 -1835.0
GRPEL1 -1783.0
HSPA9 -1728.0
PAM16 -1502.0
COQ2 -1362.0
CHCHD3 -1326.0
TIMM23 -1011.5
TOMM7 -884.0
CS -851.0
CHCHD5 -505.0
ACO2 440.0
PITRM1 491.0
CHCHD4 840.0
BCS1L 1094.0
GFER 1187.0
TIMM8B 1240.0
HSPD1 1417.0
PMPCA 1841.0
CHCHD10 2028.0
TOMM20 2356.0
TOMM5 2581.0
CMC4 2734.0
HSCB 3530.0
COA6 4923.0



tRNA processing in the mitochondrion

tRNA processing in the mitochondrion
1271
set tRNA processing in the mitochondrion
setSize 11
pANOVA 0.0404
s.dist 0.357
p.adjustANOVA 0.259



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-ND5 5668
MT-CO1 5486
MT-ND2 5332
MT-CYB 4433
MT-ND1 3455
MT-ND4 2169
TRNT1 2112
MT-ND6 1064
HSD17B10 343
ELAC2 -1660
TRMT10C -4342

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ND5 5668
MT-CO1 5486
MT-ND2 5332
MT-CYB 4433
MT-ND1 3455
MT-ND4 2169
TRNT1 2112
MT-ND6 1064
HSD17B10 343
ELAC2 -1660
TRMT10C -4342



Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs
104
set Biosynthesis of DHA-derived SPMs
setSize 12
pANOVA 0.0337
s.dist -0.354
p.adjustANOVA 0.235



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP2D6 -5698.0
CYP2C8 -5670.0
CYP2C9 -5670.0
CYP3A4 -5039.5
ALOX12 -5005.0
CYP2E1 -4416.0
GSTM4 -3355.0
GPX4 -2384.0
EPHX2 -856.0
LTA4H 3195.0
HPGD 5617.0
ALOX5 5693.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP2D6 -5698.0
CYP2C8 -5670.0
CYP2C9 -5670.0
CYP3A4 -5039.5
ALOX12 -5005.0
CYP2E1 -4416.0
GSTM4 -3355.0
GPX4 -2384.0
EPHX2 -856.0
LTA4H 3195.0
HPGD 5617.0
ALOX5 5693.0



AKT phosphorylates targets in the cytosol

AKT phosphorylates targets in the cytosol
8
set AKT phosphorylates targets in the cytosol
setSize 14
pANOVA 0.0226
s.dist 0.352
p.adjustANOVA 0.183



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1A 5945.0
AKT1 4605.0
AKT3 4518.0
CHUK 4512.0
MDM2 3934.0
BAD 3650.0
GSK3B 2427.0
MKRN1 1383.0
GSK3A 939.5
TSC2 545.0
CASP9 347.0
AKT2 120.0
AKT1S1 -326.0
CDKN1B -2373.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1A 5945.0
AKT1 4605.0
AKT3 4518.0
CHUK 4512.0
MDM2 3934.0
BAD 3650.0
GSK3B 2427.0
MKRN1 1383.0
GSK3A 939.5
TSC2 545.0
CASP9 347.0
AKT2 120.0
AKT1S1 -326.0
CDKN1B -2373.0



Methylation

Methylation
601
set Methylation
setSize 12
pANOVA 0.0354
s.dist -0.351
p.adjustANOVA 0.241



Top enriched genes

Top 20 genes
GeneID Gene Rank
AHCY -5681
MAT2A -5437
MAT1A -4998
TPMT -4352
N6AMT1 -4105
AS3MT -3949
MAT2B -3763
COMT -345
MTR 1067
GSTO1 1129
NNMT 3404
MTRR 3669

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AHCY -5681
MAT2A -5437
MAT1A -4998
TPMT -4352
N6AMT1 -4105
AS3MT -3949
MAT2B -3763
COMT -345
MTR 1067
GSTO1 1129
NNMT 3404
MTRR 3669



Interferon alpha/beta signaling

Interferon alpha/beta signaling
505
set Interferon alpha/beta signaling
setSize 40
pANOVA 0.000137
s.dist 0.349
p.adjustANOVA 0.007



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFITM1 5913
IFITM2 5913
IFITM3 5913
SOCS3 5907
OAS2 5736
IRF5 5622
IRF9 5564
SAMHD1 5268
SOCS1 5145
STAT2 5077
IRF1 5033
PSMB8 4990
IRF4 4832
IRF2 4825
PTPN6 4679
RNASEL 3822
PTPN1 3681
EGR1 3582
IFNAR2 3097
XAF1 2880

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFITM1 5913.0
IFITM2 5913.0
IFITM3 5913.0
SOCS3 5907.0
OAS2 5736.0
IRF5 5622.0
IRF9 5564.0
SAMHD1 5268.0
SOCS1 5145.0
STAT2 5077.0
IRF1 5033.0
PSMB8 4990.0
IRF4 4832.0
IRF2 4825.0
PTPN6 4679.0
RNASEL 3822.0
PTPN1 3681.0
EGR1 3582.0
IFNAR2 3097.0
XAF1 2880.0
IRF8 2675.0
ADAR 2549.0
BST2 2537.0
IFNAR1 2439.0
IFI35 2007.0
ISG20 925.0
PTPN11 894.0
JAK1 58.0
TYK2 -218.0
IFIT3 -277.0
IFI27 -381.0
RSAD2 -1599.0
STAT1 -1769.0
IFIT2 -1770.0
IRF7 -2069.0
ABCE1 -2182.0
IP6K2 -2229.0
USP18 -4060.5
ISG15 -4499.0
IRF3 -5162.0



Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
172
set Citric acid cycle (TCA cycle)
setSize 22
pANOVA 0.00486
s.dist -0.347
p.adjustANOVA 0.0711



Top enriched genes

Top 20 genes
GeneID Gene Rank
SUCLG2 -5348
FAHD1 -5101
SUCLG1 -3962
IDH3G -3771
SUCLA2 -3191
MDH2 -3089
ME3 -3033
FH -2925
SDHA -2824
DLD -2805
IDH3A -2667
IDH3B -2370
SDHB -2281
DLST -1804
SDHD -1479
NNT -1171
CS -851
IDH2 -615
ACO2 440
SDHC 1075

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUCLG2 -5348
FAHD1 -5101
SUCLG1 -3962
IDH3G -3771
SUCLA2 -3191
MDH2 -3089
ME3 -3033
FH -2925
SDHA -2824
DLD -2805
IDH3A -2667
IDH3B -2370
SDHB -2281
DLST -1804
SDHD -1479
NNT -1171
CS -851
IDH2 -615
ACO2 440
SDHC 1075
OGDH 2399
ME2 3080



Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
475
set Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
setSize 33
pANOVA 0.000625
s.dist 0.344
p.adjustANOVA 0.0189



Top enriched genes

Top 20 genes
GeneID Gene Rank
LILRB4 5918.0
IFITM1 5913.0
C3 5872.0
CD300LB 5851.0
SIGLEC1 5798.0
ITGB2 5540.0
TYROBP 5517.0
CD34 5442.0
B2M 5335.0
FCGR1A 5223.5
CD300LD 5128.5
CD300LF 5128.5
FCGR2B 5002.5
CD40 4550.0
ICAM1 4520.0
NPDC1 3865.0
COLEC12 3406.0
ITGA4 3320.0
ITGAL 3258.0
ITGB7 3119.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LILRB4 5918.0
IFITM1 5913.0
C3 5872.0
CD300LB 5851.0
SIGLEC1 5798.0
ITGB2 5540.0
TYROBP 5517.0
CD34 5442.0
B2M 5335.0
FCGR1A 5223.5
CD300LD 5128.5
CD300LF 5128.5
FCGR2B 5002.5
CD40 4550.0
ICAM1 4520.0
NPDC1 3865.0
COLEC12 3406.0
ITGA4 3320.0
ITGAL 3258.0
ITGB7 3119.0
CD1D 2877.0
ITGB1 1955.0
VCAM1 1893.0
CD81 421.0
CD300LG 359.0
CD247 -2385.0
ICAM2 -3782.0
CD200 -4016.0
PIANP -4540.0
TREM2 -4736.0
ICAM4 -5185.0
CD300A -5476.5
CD300C -5476.5



Peroxisomal lipid metabolism

Peroxisomal lipid metabolism
749
set Peroxisomal lipid metabolism
setSize 24
pANOVA 0.00367
s.dist -0.343
p.adjustANOVA 0.0584



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC27A2 -5712
NUDT19 -5395
ACBD4 -5358
NUDT7 -4866
DECR2 -4803
AMACR -4705
CROT -4441
PECR -4408
PHYH -3986
HACL1 -3694
ALDH3A2 -3402
ABCD1 -2803
ECI2 -2369
HSD17B4 -2074
SCP2 -1251
ACOX3 -689
MLYCD 73
ACOX1 382
ACOT8 611
CRAT 1472

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC27A2 -5712
NUDT19 -5395
ACBD4 -5358
NUDT7 -4866
DECR2 -4803
AMACR -4705
CROT -4441
PECR -4408
PHYH -3986
HACL1 -3694
ALDH3A2 -3402
ABCD1 -2803
ECI2 -2369
HSD17B4 -2074
SCP2 -1251
ACOX3 -689
MLYCD 73
ACOX1 382
ACOT8 611
CRAT 1472
ACBD5 2042
EHHADH 2480
SLC25A17 3074
ACOT6 4283



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] MASS_7.3-51.6               fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [49] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [52] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [55] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [58] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [61] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [64] evaluate_0.14          lattice_0.20-41        htmlwidgets_1.5.1     
## [67] bit_1.1-15.2           tidyselect_1.1.0       plyr_1.8.6            
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          locfit_1.5-9.4         grid_4.0.2            
## [85] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [88] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [91] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report