Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-11-16
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## FSHD hu_model Watt_m Jones_m
## A4GALT 2.81314560 -14.988939 0.8182771 5.5001019
## AAAS -0.15717628 -2.435804 0.3877972 0.7776159
## AACS 0.05482256 -1.581711 4.1420212 11.1737053
## AAED1 4.15163719 -1.286093 -0.8848853 -39.4294484
## AAGAB -2.32526173 -1.722220 -1.3839648 0.2777522
## AAK1 1.06457576 14.833940 0.4269837 -1.5398326Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 10538 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 6164 |
| num_profile_genes_not_in_sets | 4374 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2408 |
| num_genesets_excluded | 1179 |
| num_genesets_included | 1229 |
| FSHD | hu_model | Watt_m | Jones_m | Count | |
|---|---|---|---|---|---|
| 1 | -1 | -1 | -1 | -1 | 1515 |
| 2 | 1 | -1 | -1 | -1 | 606 |
| 3 | -1 | 0 | -1 | -1 | 1 |
| 4 | -1 | 1 | -1 | -1 | 1083 |
| 5 | 1 | 1 | -1 | -1 | 417 |
| 6 | -1 | -1 | 1 | -1 | 383 |
| 7 | 1 | -1 | 1 | -1 | 300 |
| 8 | -1 | 1 | 1 | -1 | 659 |
| 9 | 1 | 1 | 1 | -1 | 340 |
| 10 | -1 | -1 | -1 | 0 | 1 |
| 11 | -1 | -1 | -1 | 1 | 400 |
| 12 | 0 | -1 | -1 | 1 | 1 |
| 13 | 1 | -1 | -1 | 1 | 598 |
| 14 | -1 | 1 | -1 | 1 | 357 |
| 15 | 1 | 1 | -1 | 1 | 337 |
| 16 | 1 | 1 | 0 | 1 | 1 |
| 17 | -1 | -1 | 1 | 1 | 437 |
| 18 | 1 | -1 | 1 | 1 | 1324 |
| 19 | -1 | 1 | 1 | 1 | 614 |
| 20 | 1 | 1 | 1 | 1 | 1164 |
Gene sets by sector
| s.FSHD | s.hu_model | s.Watt_m | s.Jones_m | Count | |
|---|---|---|---|---|---|
| 1 | -1 | -1 | -1 | -1 | 46 |
| 2 | 1 | -1 | -1 | -1 | 12 |
| 3 | -1 | 1 | -1 | -1 | 20 |
| 4 | -1 | -1 | 1 | -1 | 14 |
| 5 | 1 | -1 | 1 | -1 | 6 |
| 6 | -1 | 1 | 1 | -1 | 142 |
| 7 | -1 | -1 | -1 | 1 | 2 |
| 8 | 1 | -1 | -1 | 1 | 44 |
| 9 | -1 | 1 | -1 | 1 | 2 |
| 10 | 1 | 1 | -1 | 1 | 4 |
| 11 | -1 | -1 | 1 | 1 | 3 |
| 12 | 1 | -1 | 1 | 1 | 135 |
| 13 | -1 | 1 | 1 | 1 | 139 |
| 14 | 1 | 1 | 1 | 1 | 41 |
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 100 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.FSHD | s.hu_model | s.Watt_m | s.Jones_m | p.FSHD | p.hu_model | p.Watt_m | p.Jones_m |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interleukin-10 signaling | 11 | 1.12e-06 | 8.69e-06 | 1.310 | 0.7360 | -0.25200 | 0.74800 | 0.742 | 2.34e-05 | 1.48e-01 | 1.74e-05 | 2.03e-05 |
| Citric acid cycle (TCA cycle) | 21 | 6.96e-09 | 8.14e-08 | 1.100 | -0.6690 | -0.24300 | -0.59700 | -0.585 | 1.09e-07 | 5.43e-02 | 2.21e-06 | 3.42e-06 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 13 | 1.14e-05 | 6.63e-05 | 1.050 | 0.7670 | 0.11300 | 0.32400 | 0.622 | 1.66e-06 | 4.81e-01 | 4.30e-02 | 1.02e-04 |
| Branched-chain amino acid catabolism | 20 | 9.57e-07 | 7.69e-06 | 1.000 | -0.6120 | -0.07400 | -0.53100 | -0.586 | 2.18e-06 | 5.67e-01 | 3.92e-05 | 5.68e-06 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 49 | 3.58e-17 | 1.69e-15 | 0.990 | -0.5710 | -0.26300 | -0.55900 | -0.522 | 4.77e-12 | 1.46e-03 | 1.28e-11 | 2.63e-10 |
| Signal regulatory protein family interactions | 10 | 6.38e-04 | 2.26e-03 | 0.988 | 0.5440 | -0.41200 | 0.50700 | 0.504 | 2.92e-03 | 2.42e-02 | 5.47e-03 | 5.77e-03 |
| Glyoxylate metabolism and glycine degradation | 20 | 4.39e-07 | 3.83e-06 | 0.985 | -0.6690 | -0.17200 | -0.51100 | -0.481 | 2.24e-07 | 1.83e-01 | 7.56e-05 | 1.98e-04 |
| The NLRP3 inflammasome | 10 | 2.77e-03 | 8.04e-03 | 0.978 | 0.5410 | -0.08910 | 0.49000 | 0.645 | 3.04e-03 | 6.26e-01 | 7.31e-03 | 4.11e-04 |
| Prolactin receptor signaling | 10 | 3.91e-03 | 1.09e-02 | 0.957 | -0.4690 | -0.24600 | -0.53600 | -0.591 | 1.03e-02 | 1.78e-01 | 3.34e-03 | 1.22e-03 |
| Post-chaperonin tubulin folding pathway | 15 | 3.49e-06 | 2.34e-05 | 0.923 | 0.3150 | -0.48300 | 0.55600 | 0.459 | 3.48e-02 | 1.22e-03 | 1.94e-04 | 2.10e-03 |
| Inflammasomes | 12 | 1.05e-03 | 3.54e-03 | 0.922 | 0.4760 | -0.21800 | 0.44600 | 0.614 | 4.32e-03 | 1.90e-01 | 7.46e-03 | 2.30e-04 |
| Mitochondrial tRNA aminoacylation | 18 | 2.69e-06 | 1.84e-05 | 0.913 | -0.6090 | 0.17900 | -0.56500 | -0.334 | 7.59e-06 | 1.89e-01 | 3.36e-05 | 1.42e-02 |
| Complex I biogenesis | 52 | 8.57e-16 | 3.51e-14 | 0.913 | -0.5510 | -0.19600 | -0.40100 | -0.575 | 6.54e-12 | 1.46e-02 | 5.92e-07 | 7.40e-13 |
| Mitochondrial Fatty Acid Beta-Oxidation | 29 | 2.61e-09 | 3.31e-08 | 0.903 | -0.5160 | -0.35100 | -0.53700 | -0.370 | 1.55e-06 | 1.06e-03 | 5.49e-07 | 5.68e-04 |
| Degradation of cysteine and homocysteine | 12 | 5.19e-04 | 1.93e-03 | 0.902 | -0.2890 | -0.30200 | -0.40700 | -0.688 | 8.33e-02 | 7.00e-02 | 1.47e-02 | 3.64e-05 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 15 | 1.96e-04 | 8.14e-04 | 0.901 | -0.4690 | -0.16200 | -0.63100 | -0.411 | 1.67e-03 | 2.78e-01 | 2.34e-05 | 5.88e-03 |
| Interferon alpha/beta signaling | 36 | 3.95e-10 | 5.72e-09 | 0.883 | 0.5950 | -0.00808 | 0.35000 | 0.551 | 6.56e-10 | 9.33e-01 | 2.78e-04 | 1.05e-08 |
| Chondroitin sulfate biosynthesis | 13 | 3.80e-04 | 1.47e-03 | 0.875 | 0.7180 | -0.10600 | 0.28600 | 0.396 | 7.36e-06 | 5.07e-01 | 7.43e-02 | 1.33e-02 |
| PECAM1 interactions | 10 | 5.25e-03 | 1.39e-02 | 0.873 | 0.5160 | -0.25000 | 0.28300 | 0.594 | 4.72e-03 | 1.70e-01 | 1.21e-01 | 1.15e-03 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | 14 | 1.06e-04 | 4.81e-04 | 0.865 | 0.6150 | -0.45400 | 0.21200 | 0.344 | 6.71e-05 | 3.25e-03 | 1.70e-01 | 2.61e-02 |
| Pyruvate metabolism | 26 | 7.39e-07 | 6.05e-06 | 0.863 | -0.4910 | -0.22800 | -0.52200 | -0.423 | 1.48e-05 | 4.45e-02 | 4.18e-06 | 1.88e-04 |
| HS-GAG degradation | 16 | 5.14e-06 | 3.39e-05 | 0.860 | 0.5730 | -0.43500 | -0.01360 | 0.471 | 7.20e-05 | 2.62e-03 | 9.25e-01 | 1.10e-03 |
| Defective B3GAT3 causes JDSSDHD | 14 | 6.44e-05 | 3.10e-04 | 0.860 | 0.6190 | -0.49400 | 0.17500 | 0.285 | 6.16e-05 | 1.37e-03 | 2.58e-01 | 6.46e-02 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 10 | 1.86e-03 | 5.71e-03 | 0.857 | 0.1020 | 0.11500 | 0.47500 | 0.697 | 5.76e-01 | 5.31e-01 | 9.26e-03 | 1.36e-04 |
| The citric acid (TCA) cycle and respiratory electron transport | 142 | 4.04e-38 | 1.24e-35 | 0.856 | -0.5290 | -0.20200 | -0.42300 | -0.482 | 1.42e-27 | 3.56e-05 | 3.80e-18 | 3.89e-23 |
| Respiratory electron transport | 92 | 2.25e-24 | 2.31e-22 | 0.841 | -0.5490 | -0.17700 | -0.36700 | -0.490 | 9.03e-20 | 3.34e-03 | 1.22e-09 | 5.01e-16 |
| tRNA Aminoacylation | 24 | 2.34e-06 | 1.63e-05 | 0.840 | -0.5880 | 0.18500 | -0.40500 | -0.402 | 6.22e-07 | 1.18e-01 | 5.97e-04 | 6.65e-04 |
| Mucopolysaccharidoses | 11 | 4.04e-04 | 1.56e-03 | 0.834 | 0.4630 | -0.33500 | 0.00854 | 0.607 | 7.83e-03 | 5.44e-02 | 9.61e-01 | 4.86e-04 |
| Defective B4GALT7 causes EDS, progeroid type | 14 | 1.58e-04 | 6.78e-04 | 0.828 | 0.5740 | -0.49300 | 0.13600 | 0.308 | 2.03e-04 | 1.40e-03 | 3.79e-01 | 4.58e-02 |
| Activation of Matrix Metalloproteinases | 11 | 2.43e-03 | 7.24e-03 | 0.826 | 0.6550 | -0.30700 | 0.19300 | 0.349 | 1.69e-04 | 7.82e-02 | 2.68e-01 | 4.48e-02 |
| Scavenging by Class A Receptors | 13 | 1.56e-03 | 4.93e-03 | 0.817 | 0.6000 | -0.19500 | 0.20400 | 0.478 | 1.80e-04 | 2.23e-01 | 2.04e-01 | 2.84e-03 |
| rRNA processing in the mitochondrion | 11 | 1.03e-02 | 2.43e-02 | 0.814 | -0.5890 | -0.03730 | -0.36700 | -0.423 | 7.14e-04 | 8.30e-01 | 3.50e-02 | 1.52e-02 |
| Carnitine metabolism | 11 | 3.97e-03 | 1.11e-02 | 0.813 | -0.2750 | -0.43400 | -0.56800 | -0.272 | 1.14e-01 | 1.28e-02 | 1.12e-03 | 1.18e-01 |
| Cell recruitment (pro-inflammatory response) | 12 | 8.63e-03 | 2.09e-02 | 0.810 | 0.5180 | -0.02050 | 0.34700 | 0.517 | 1.89e-03 | 9.02e-01 | 3.72e-02 | 1.94e-03 |
| Purinergic signaling in leishmaniasis infection | 12 | 8.63e-03 | 2.09e-02 | 0.810 | 0.5180 | -0.02050 | 0.34700 | 0.517 | 1.89e-03 | 9.02e-01 | 3.72e-02 | 1.94e-03 |
| A tetrasaccharide linker sequence is required for GAG synthesis | 18 | 1.98e-05 | 1.07e-04 | 0.797 | 0.6000 | -0.41300 | 0.21000 | 0.246 | 1.06e-05 | 2.43e-03 | 1.24e-01 | 7.04e-02 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 96 | 1.91e-22 | 1.47e-20 | 0.795 | -0.5080 | -0.17600 | -0.35800 | -0.464 | 8.80e-18 | 2.92e-03 | 1.41e-09 | 3.97e-15 |
| Caspase activation via Death Receptors in the presence of ligand | 11 | 1.37e-02 | 3.06e-02 | 0.789 | 0.4890 | -0.23900 | 0.33900 | 0.458 | 4.96e-03 | 1.70e-01 | 5.15e-02 | 8.50e-03 |
| Collagen degradation | 20 | 5.57e-06 | 3.58e-05 | 0.775 | 0.6020 | -0.27400 | 0.01500 | 0.403 | 3.18e-06 | 3.37e-02 | 9.07e-01 | 1.79e-03 |
| Diseases associated with the TLR signaling cascade | 16 | 9.63e-04 | 3.29e-03 | 0.772 | 0.3580 | -0.17400 | 0.31800 | 0.580 | 1.33e-02 | 2.28e-01 | 2.78e-02 | 5.89e-05 |
| Diseases of Immune System | 16 | 9.63e-04 | 3.29e-03 | 0.772 | 0.3580 | -0.17400 | 0.31800 | 0.580 | 1.33e-02 | 2.28e-01 | 2.78e-02 | 5.89e-05 |
| Mitochondrial calcium ion transport | 21 | 7.14e-05 | 3.39e-04 | 0.772 | -0.5980 | -0.01110 | -0.33800 | -0.351 | 2.12e-06 | 9.30e-01 | 7.32e-03 | 5.33e-03 |
| MET activates PTK2 signaling | 14 | 3.31e-04 | 1.31e-03 | 0.769 | 0.5870 | -0.43100 | 0.03610 | 0.244 | 1.44e-04 | 5.24e-03 | 8.15e-01 | 1.14e-01 |
| Acyl chain remodelling of PS | 10 | 1.23e-02 | 2.79e-02 | 0.767 | 0.4140 | 0.21800 | 0.21500 | 0.568 | 2.33e-02 | 2.34e-01 | 2.38e-01 | 1.86e-03 |
| Voltage gated Potassium channels | 11 | 1.04e-03 | 3.54e-03 | 0.767 | 0.2120 | -0.52800 | -0.36100 | -0.365 | 2.23e-01 | 2.43e-03 | 3.80e-02 | 3.59e-02 |
| Mitochondrial translation | 87 | 1.59e-19 | 1.02e-17 | 0.764 | -0.5540 | 0.15900 | -0.31500 | -0.389 | 4.10e-19 | 1.07e-02 | 4.08e-07 | 3.59e-10 |
| Syndecan interactions | 17 | 1.45e-03 | 4.64e-03 | 0.761 | 0.5440 | -0.04840 | 0.35700 | 0.392 | 1.04e-04 | 7.30e-01 | 1.08e-02 | 5.21e-03 |
| N-Glycan antennae elongation | 12 | 6.08e-03 | 1.56e-02 | 0.759 | 0.2620 | -0.26000 | 0.42900 | 0.505 | 1.16e-01 | 1.18e-01 | 1.00e-02 | 2.47e-03 |
| Other interleukin signaling | 13 | 7.41e-03 | 1.84e-02 | 0.757 | 0.5540 | -0.13100 | 0.26700 | 0.421 | 5.43e-04 | 4.12e-01 | 9.55e-02 | 8.60e-03 |
| Biotin transport and metabolism | 10 | 3.96e-02 | 7.50e-02 | 0.757 | -0.3230 | -0.02010 | -0.53500 | -0.426 | 7.66e-02 | 9.12e-01 | 3.39e-03 | 1.98e-02 |
| Mitochondrial translation termination | 81 | 1.65e-17 | 8.47e-16 | 0.754 | -0.5380 | 0.15600 | -0.29300 | -0.411 | 5.73e-17 | 1.52e-02 | 5.20e-06 | 1.77e-10 |
| Mitochondrial translation elongation | 81 | 1.59e-17 | 8.47e-16 | 0.753 | -0.5420 | 0.15900 | -0.29700 | -0.399 | 3.57e-17 | 1.37e-02 | 3.81e-06 | 5.70e-10 |
| Gluconeogenesis | 21 | 1.67e-05 | 9.17e-05 | 0.749 | -0.0701 | -0.55500 | -0.35200 | -0.352 | 5.78e-01 | 1.06e-05 | 5.28e-03 | 5.23e-03 |
| Integrin cell surface interactions | 45 | 1.02e-11 | 1.98e-10 | 0.748 | 0.5990 | -0.23100 | 0.09650 | 0.372 | 3.67e-12 | 7.31e-03 | 2.63e-01 | 1.63e-05 |
| CS/DS degradation | 10 | 2.00e-02 | 4.18e-02 | 0.746 | 0.4740 | -0.26500 | 0.16300 | 0.485 | 9.43e-03 | 1.47e-01 | 3.72e-01 | 7.89e-03 |
| Sema3A PAK dependent Axon repulsion | 15 | 3.33e-03 | 9.54e-03 | 0.746 | 0.3150 | -0.18300 | 0.39200 | 0.520 | 3.46e-02 | 2.20e-01 | 8.57e-03 | 4.95e-04 |
| Phase 0 - rapid depolarisation | 17 | 7.93e-05 | 3.75e-04 | 0.746 | -0.0740 | -0.62200 | -0.26000 | -0.310 | 5.98e-01 | 8.98e-06 | 6.35e-02 | 2.69e-02 |
| Chondroitin sulfate/dermatan sulfate metabolism | 37 | 1.73e-08 | 1.82e-07 | 0.744 | 0.5660 | -0.22600 | 0.19400 | 0.380 | 2.58e-09 | 1.73e-02 | 4.15e-02 | 6.48e-05 |
| Elastic fibre formation | 34 | 1.94e-07 | 1.82e-06 | 0.743 | 0.5880 | -0.04050 | 0.28000 | 0.356 | 2.98e-09 | 6.83e-01 | 4.82e-03 | 3.36e-04 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 14 | 5.36e-03 | 1.41e-02 | 0.743 | 0.4410 | -0.21500 | 0.25700 | 0.495 | 4.32e-03 | 1.63e-01 | 9.67e-02 | 1.34e-03 |
| Regulation of Complement cascade | 13 | 3.47e-04 | 1.36e-03 | 0.741 | 0.6520 | 0.04740 | -0.00954 | 0.348 | 4.68e-05 | 7.67e-01 | 9.53e-01 | 2.97e-02 |
| Mitochondrial translation initiation | 81 | 4.72e-17 | 2.15e-15 | 0.740 | -0.5400 | 0.15200 | -0.29100 | -0.385 | 4.46e-17 | 1.84e-02 | 6.38e-06 | 2.12e-09 |
| Formation of tubulin folding intermediates by CCT/TriC | 17 | 1.34e-05 | 7.63e-05 | 0.739 | 0.0756 | -0.09460 | 0.68300 | 0.255 | 5.89e-01 | 5.00e-01 | 1.07e-06 | 6.91e-02 |
| Binding and Uptake of Ligands by Scavenger Receptors | 23 | 3.26e-05 | 1.67e-04 | 0.737 | 0.5550 | -0.15200 | 0.15700 | 0.433 | 4.15e-06 | 2.08e-01 | 1.92e-01 | 3.30e-04 |
| tRNA processing in the mitochondrion | 11 | 1.28e-02 | 2.88e-02 | 0.736 | -0.6160 | 0.02140 | -0.25900 | -0.307 | 4.00e-04 | 9.02e-01 | 1.37e-01 | 7.80e-02 |
| Defects in vitamin and cofactor metabolism | 17 | 1.55e-03 | 4.92e-03 | 0.735 | -0.3460 | 0.10500 | -0.52300 | -0.368 | 1.35e-02 | 4.52e-01 | 1.89e-04 | 8.64e-03 |
| Degradation of the extracellular matrix | 58 | 8.33e-14 | 2.38e-12 | 0.734 | 0.5400 | -0.30100 | 0.14100 | 0.370 | 1.11e-12 | 7.64e-05 | 6.28e-02 | 1.15e-06 |
| Regulation of IFNA signaling | 12 | 2.77e-02 | 5.51e-02 | 0.732 | 0.4190 | -0.03780 | 0.34500 | 0.489 | 1.19e-02 | 8.21e-01 | 3.85e-02 | 3.35e-03 |
| Metabolism of steroid hormones | 12 | 9.82e-03 | 2.32e-02 | 0.732 | 0.2180 | -0.11700 | 0.38700 | 0.569 | 1.90e-01 | 4.85e-01 | 2.02e-02 | 6.42e-04 |
| Interleukin-4 and Interleukin-13 signaling | 64 | 4.20e-12 | 9.07e-11 | 0.731 | 0.4280 | -0.13000 | 0.40100 | 0.416 | 3.24e-09 | 7.28e-02 | 2.88e-08 | 8.56e-09 |
| ECM proteoglycans | 37 | 9.76e-09 | 1.12e-07 | 0.730 | 0.5690 | -0.27000 | 0.14300 | 0.341 | 2.08e-09 | 4.58e-03 | 1.33e-01 | 3.40e-04 |
| Collagen biosynthesis and modifying enzymes | 47 | 3.12e-11 | 5.48e-10 | 0.729 | 0.5000 | -0.35200 | 0.11700 | 0.379 | 3.16e-09 | 3.02e-05 | 1.67e-01 | 7.07e-06 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 12 | 1.16e-02 | 2.66e-02 | 0.726 | 0.2740 | -0.19300 | 0.50300 | 0.403 | 1.00e-01 | 2.47e-01 | 2.57e-03 | 1.58e-02 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 10 | 6.13e-02 | 1.06e-01 | 0.725 | -0.3860 | -0.14100 | -0.46800 | -0.371 | 3.44e-02 | 4.42e-01 | 1.05e-02 | 4.20e-02 |
| Laminin interactions | 19 | 1.99e-05 | 1.07e-04 | 0.724 | 0.5750 | -0.34400 | -0.06030 | 0.268 | 1.44e-05 | 9.38e-03 | 6.49e-01 | 4.34e-02 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 11 | 1.14e-02 | 2.64e-02 | 0.723 | 0.5370 | -0.36000 | 0.16200 | 0.280 | 2.04e-03 | 3.89e-02 | 3.52e-01 | 1.08e-01 |
| Defective EXT2 causes exostoses 2 | 11 | 1.14e-02 | 2.64e-02 | 0.723 | 0.5370 | -0.36000 | 0.16200 | 0.280 | 2.04e-03 | 3.89e-02 | 3.52e-01 | 1.08e-01 |
| rRNA modification in the nucleus and cytosol | 52 | 1.28e-15 | 4.91e-14 | 0.722 | -0.1810 | 0.60100 | 0.35700 | 0.011 | 2.44e-02 | 6.53e-14 | 8.81e-06 | 8.91e-01 |
| RHO GTPases Activate WASPs and WAVEs | 31 | 2.90e-05 | 1.49e-04 | 0.718 | 0.3620 | 0.09060 | 0.42800 | 0.440 | 4.85e-04 | 3.83e-01 | 3.82e-05 | 2.24e-05 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 10 | 9.89e-04 | 3.37e-03 | 0.717 | 0.1140 | -0.24500 | 0.05040 | 0.662 | 5.32e-01 | 1.80e-01 | 7.82e-01 | 2.88e-04 |
| FCGR3A-mediated phagocytosis | 47 | 5.38e-08 | 5.42e-07 | 0.713 | 0.3840 | -0.01190 | 0.37700 | 0.467 | 5.20e-06 | 8.88e-01 | 8.09e-06 | 3.05e-08 |
| Leishmania phagocytosis | 47 | 5.38e-08 | 5.42e-07 | 0.713 | 0.3840 | -0.01190 | 0.37700 | 0.467 | 5.20e-06 | 8.88e-01 | 8.09e-06 | 3.05e-08 |
| Parasite infection | 47 | 5.38e-08 | 5.42e-07 | 0.713 | 0.3840 | -0.01190 | 0.37700 | 0.467 | 5.20e-06 | 8.88e-01 | 8.09e-06 | 3.05e-08 |
| Cristae formation | 10 | 5.76e-02 | 1.02e-01 | 0.712 | -0.5120 | 0.05020 | -0.29300 | -0.395 | 5.03e-03 | 7.84e-01 | 1.09e-01 | 3.04e-02 |
| Collagen formation | 63 | 7.69e-15 | 2.62e-13 | 0.711 | 0.5070 | -0.30900 | 0.08070 | 0.383 | 3.43e-12 | 2.29e-05 | 2.69e-01 | 1.45e-07 |
| Extracellular matrix organization | 192 | 7.97e-44 | 3.27e-41 | 0.711 | 0.5450 | -0.25800 | 0.14200 | 0.348 | 9.51e-39 | 8.04e-10 | 7.16e-04 | 1.07e-16 |
| Glycogen storage diseases | 11 | 2.64e-03 | 7.75e-03 | 0.709 | -0.3700 | -0.40700 | -0.06070 | -0.443 | 3.38e-02 | 1.95e-02 | 7.27e-01 | 1.09e-02 |
| Diseases associated with glycosaminoglycan metabolism | 30 | 1.97e-06 | 1.41e-05 | 0.708 | 0.5650 | -0.21700 | 0.19300 | 0.311 | 8.36e-08 | 3.97e-02 | 6.70e-02 | 3.26e-03 |
| Condensation of Prophase Chromosomes | 11 | 6.32e-04 | 2.24e-03 | 0.706 | -0.1530 | 0.37300 | 0.18800 | 0.548 | 3.80e-01 | 3.21e-02 | 2.79e-01 | 1.67e-03 |
| Postmitotic nuclear pore complex (NPC) reformation | 24 | 1.70e-06 | 1.23e-05 | 0.705 | -0.1870 | 0.54400 | 0.35100 | 0.208 | 1.14e-01 | 4.01e-06 | 2.97e-03 | 7.72e-02 |
| Processing of SMDT1 | 15 | 2.49e-03 | 7.38e-03 | 0.703 | -0.5840 | 0.14900 | -0.26800 | -0.244 | 9.01e-05 | 3.18e-01 | 7.29e-02 | 1.01e-01 |
| GPVI-mediated activation cascade | 18 | 3.88e-03 | 1.09e-02 | 0.701 | 0.2350 | 0.16000 | 0.46100 | 0.444 | 8.40e-02 | 2.41e-01 | 7.03e-04 | 1.11e-03 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 10 | 4.97e-02 | 9.06e-02 | 0.700 | -0.1980 | -0.37900 | -0.42600 | -0.356 | 2.78e-01 | 3.82e-02 | 1.98e-02 | 5.12e-02 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 34 | 3.73e-07 | 3.32e-06 | 0.695 | 0.5370 | -0.27200 | 0.17300 | 0.300 | 5.94e-08 | 6.01e-03 | 8.04e-02 | 2.48e-03 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 65 | 2.15e-13 | 5.63e-12 | 0.694 | 0.5570 | -0.09370 | 0.16900 | 0.367 | 8.07e-15 | 1.92e-01 | 1.88e-02 | 3.29e-07 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | 20 | 6.74e-05 | 3.22e-04 | 0.689 | 0.1790 | -0.42200 | 0.31100 | 0.409 | 1.67e-01 | 1.08e-03 | 1.62e-02 | 1.55e-03 |
| Assembly of collagen fibrils and other multimeric structures | 42 | 4.73e-10 | 6.68e-09 | 0.688 | 0.5060 | -0.28400 | 0.00267 | 0.370 | 1.42e-08 | 1.46e-03 | 9.76e-01 | 3.32e-05 |
| Synthesis of bile acids and bile salts | 18 | 7.00e-03 | 1.76e-02 | 0.687 | -0.3920 | -0.09860 | -0.39500 | -0.391 | 4.00e-03 | 4.69e-01 | 3.70e-03 | 4.13e-03 |
| Heme biosynthesis | 12 | 1.48e-02 | 3.23e-02 | 0.686 | -0.1320 | -0.12700 | -0.58000 | -0.317 | 4.29e-01 | 4.45e-01 | 4.99e-04 | 5.77e-02 |
| Post-translational protein phosphorylation | 62 | 4.30e-12 | 9.12e-11 | 0.686 | 0.5430 | -0.07840 | 0.18700 | 0.367 | 1.48e-13 | 2.87e-01 | 1.10e-02 | 5.90e-07 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.FSHD | s.hu_model | s.Watt_m | s.Jones_m | p.FSHD | p.hu_model | p.Watt_m | p.Jones_m |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interleukin-10 signaling | 11 | 1.12e-06 | 8.69e-06 | 1.3100 | 0.736000 | -0.252000 | 0.748000 | 0.742000 | 2.34e-05 | 1.48e-01 | 1.74e-05 | 2.03e-05 |
| Citric acid cycle (TCA cycle) | 21 | 6.96e-09 | 8.14e-08 | 1.1000 | -0.669000 | -0.243000 | -0.597000 | -0.585000 | 1.09e-07 | 5.43e-02 | 2.21e-06 | 3.42e-06 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 13 | 1.14e-05 | 6.63e-05 | 1.0500 | 0.767000 | 0.113000 | 0.324000 | 0.622000 | 1.66e-06 | 4.81e-01 | 4.30e-02 | 1.02e-04 |
| Branched-chain amino acid catabolism | 20 | 9.57e-07 | 7.69e-06 | 1.0000 | -0.612000 | -0.074000 | -0.531000 | -0.586000 | 2.18e-06 | 5.67e-01 | 3.92e-05 | 5.68e-06 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 49 | 3.58e-17 | 1.69e-15 | 0.9900 | -0.571000 | -0.263000 | -0.559000 | -0.522000 | 4.77e-12 | 1.46e-03 | 1.28e-11 | 2.63e-10 |
| Signal regulatory protein family interactions | 10 | 6.38e-04 | 2.26e-03 | 0.9880 | 0.544000 | -0.412000 | 0.507000 | 0.504000 | 2.92e-03 | 2.42e-02 | 5.47e-03 | 5.77e-03 |
| Glyoxylate metabolism and glycine degradation | 20 | 4.39e-07 | 3.83e-06 | 0.9850 | -0.669000 | -0.172000 | -0.511000 | -0.481000 | 2.24e-07 | 1.83e-01 | 7.56e-05 | 1.98e-04 |
| The NLRP3 inflammasome | 10 | 2.77e-03 | 8.04e-03 | 0.9780 | 0.541000 | -0.089100 | 0.490000 | 0.645000 | 3.04e-03 | 6.26e-01 | 7.31e-03 | 4.11e-04 |
| Prolactin receptor signaling | 10 | 3.91e-03 | 1.09e-02 | 0.9570 | -0.469000 | -0.246000 | -0.536000 | -0.591000 | 1.03e-02 | 1.78e-01 | 3.34e-03 | 1.22e-03 |
| Post-chaperonin tubulin folding pathway | 15 | 3.49e-06 | 2.34e-05 | 0.9230 | 0.315000 | -0.483000 | 0.556000 | 0.459000 | 3.48e-02 | 1.22e-03 | 1.94e-04 | 2.10e-03 |
| Inflammasomes | 12 | 1.05e-03 | 3.54e-03 | 0.9220 | 0.476000 | -0.218000 | 0.446000 | 0.614000 | 4.32e-03 | 1.90e-01 | 7.46e-03 | 2.30e-04 |
| Mitochondrial tRNA aminoacylation | 18 | 2.69e-06 | 1.84e-05 | 0.9130 | -0.609000 | 0.179000 | -0.565000 | -0.334000 | 7.59e-06 | 1.89e-01 | 3.36e-05 | 1.42e-02 |
| Complex I biogenesis | 52 | 8.57e-16 | 3.51e-14 | 0.9130 | -0.551000 | -0.196000 | -0.401000 | -0.575000 | 6.54e-12 | 1.46e-02 | 5.92e-07 | 7.40e-13 |
| Mitochondrial Fatty Acid Beta-Oxidation | 29 | 2.61e-09 | 3.31e-08 | 0.9030 | -0.516000 | -0.351000 | -0.537000 | -0.370000 | 1.55e-06 | 1.06e-03 | 5.49e-07 | 5.68e-04 |
| Degradation of cysteine and homocysteine | 12 | 5.19e-04 | 1.93e-03 | 0.9020 | -0.289000 | -0.302000 | -0.407000 | -0.688000 | 8.33e-02 | 7.00e-02 | 1.47e-02 | 3.64e-05 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 15 | 1.96e-04 | 8.14e-04 | 0.9010 | -0.469000 | -0.162000 | -0.631000 | -0.411000 | 1.67e-03 | 2.78e-01 | 2.34e-05 | 5.88e-03 |
| Interferon alpha/beta signaling | 36 | 3.95e-10 | 5.72e-09 | 0.8830 | 0.595000 | -0.008080 | 0.350000 | 0.551000 | 6.56e-10 | 9.33e-01 | 2.78e-04 | 1.05e-08 |
| Chondroitin sulfate biosynthesis | 13 | 3.80e-04 | 1.47e-03 | 0.8750 | 0.718000 | -0.106000 | 0.286000 | 0.396000 | 7.36e-06 | 5.07e-01 | 7.43e-02 | 1.33e-02 |
| PECAM1 interactions | 10 | 5.25e-03 | 1.39e-02 | 0.8730 | 0.516000 | -0.250000 | 0.283000 | 0.594000 | 4.72e-03 | 1.70e-01 | 1.21e-01 | 1.15e-03 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | 14 | 1.06e-04 | 4.81e-04 | 0.8650 | 0.615000 | -0.454000 | 0.212000 | 0.344000 | 6.71e-05 | 3.25e-03 | 1.70e-01 | 2.61e-02 |
| Pyruvate metabolism | 26 | 7.39e-07 | 6.05e-06 | 0.8630 | -0.491000 | -0.228000 | -0.522000 | -0.423000 | 1.48e-05 | 4.45e-02 | 4.18e-06 | 1.88e-04 |
| HS-GAG degradation | 16 | 5.14e-06 | 3.39e-05 | 0.8600 | 0.573000 | -0.435000 | -0.013600 | 0.471000 | 7.20e-05 | 2.62e-03 | 9.25e-01 | 1.10e-03 |
| Defective B3GAT3 causes JDSSDHD | 14 | 6.44e-05 | 3.10e-04 | 0.8600 | 0.619000 | -0.494000 | 0.175000 | 0.285000 | 6.16e-05 | 1.37e-03 | 2.58e-01 | 6.46e-02 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 10 | 1.86e-03 | 5.71e-03 | 0.8570 | 0.102000 | 0.115000 | 0.475000 | 0.697000 | 5.76e-01 | 5.31e-01 | 9.26e-03 | 1.36e-04 |
| The citric acid (TCA) cycle and respiratory electron transport | 142 | 4.04e-38 | 1.24e-35 | 0.8560 | -0.529000 | -0.202000 | -0.423000 | -0.482000 | 1.42e-27 | 3.56e-05 | 3.80e-18 | 3.89e-23 |
| Respiratory electron transport | 92 | 2.25e-24 | 2.31e-22 | 0.8410 | -0.549000 | -0.177000 | -0.367000 | -0.490000 | 9.03e-20 | 3.34e-03 | 1.22e-09 | 5.01e-16 |
| tRNA Aminoacylation | 24 | 2.34e-06 | 1.63e-05 | 0.8400 | -0.588000 | 0.185000 | -0.405000 | -0.402000 | 6.22e-07 | 1.18e-01 | 5.97e-04 | 6.65e-04 |
| Mucopolysaccharidoses | 11 | 4.04e-04 | 1.56e-03 | 0.8340 | 0.463000 | -0.335000 | 0.008540 | 0.607000 | 7.83e-03 | 5.44e-02 | 9.61e-01 | 4.86e-04 |
| Defective B4GALT7 causes EDS, progeroid type | 14 | 1.58e-04 | 6.78e-04 | 0.8280 | 0.574000 | -0.493000 | 0.136000 | 0.308000 | 2.03e-04 | 1.40e-03 | 3.79e-01 | 4.58e-02 |
| Activation of Matrix Metalloproteinases | 11 | 2.43e-03 | 7.24e-03 | 0.8260 | 0.655000 | -0.307000 | 0.193000 | 0.349000 | 1.69e-04 | 7.82e-02 | 2.68e-01 | 4.48e-02 |
| Scavenging by Class A Receptors | 13 | 1.56e-03 | 4.93e-03 | 0.8170 | 0.600000 | -0.195000 | 0.204000 | 0.478000 | 1.80e-04 | 2.23e-01 | 2.04e-01 | 2.84e-03 |
| rRNA processing in the mitochondrion | 11 | 1.03e-02 | 2.43e-02 | 0.8140 | -0.589000 | -0.037300 | -0.367000 | -0.423000 | 7.14e-04 | 8.30e-01 | 3.50e-02 | 1.52e-02 |
| Carnitine metabolism | 11 | 3.97e-03 | 1.11e-02 | 0.8130 | -0.275000 | -0.434000 | -0.568000 | -0.272000 | 1.14e-01 | 1.28e-02 | 1.12e-03 | 1.18e-01 |
| Cell recruitment (pro-inflammatory response) | 12 | 8.63e-03 | 2.09e-02 | 0.8100 | 0.518000 | -0.020500 | 0.347000 | 0.517000 | 1.89e-03 | 9.02e-01 | 3.72e-02 | 1.94e-03 |
| Purinergic signaling in leishmaniasis infection | 12 | 8.63e-03 | 2.09e-02 | 0.8100 | 0.518000 | -0.020500 | 0.347000 | 0.517000 | 1.89e-03 | 9.02e-01 | 3.72e-02 | 1.94e-03 |
| A tetrasaccharide linker sequence is required for GAG synthesis | 18 | 1.98e-05 | 1.07e-04 | 0.7970 | 0.600000 | -0.413000 | 0.210000 | 0.246000 | 1.06e-05 | 2.43e-03 | 1.24e-01 | 7.04e-02 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 96 | 1.91e-22 | 1.47e-20 | 0.7950 | -0.508000 | -0.176000 | -0.358000 | -0.464000 | 8.80e-18 | 2.92e-03 | 1.41e-09 | 3.97e-15 |
| Caspase activation via Death Receptors in the presence of ligand | 11 | 1.37e-02 | 3.06e-02 | 0.7890 | 0.489000 | -0.239000 | 0.339000 | 0.458000 | 4.96e-03 | 1.70e-01 | 5.15e-02 | 8.50e-03 |
| Collagen degradation | 20 | 5.57e-06 | 3.58e-05 | 0.7750 | 0.602000 | -0.274000 | 0.015000 | 0.403000 | 3.18e-06 | 3.37e-02 | 9.07e-01 | 1.79e-03 |
| Diseases associated with the TLR signaling cascade | 16 | 9.63e-04 | 3.29e-03 | 0.7720 | 0.358000 | -0.174000 | 0.318000 | 0.580000 | 1.33e-02 | 2.28e-01 | 2.78e-02 | 5.89e-05 |
| Diseases of Immune System | 16 | 9.63e-04 | 3.29e-03 | 0.7720 | 0.358000 | -0.174000 | 0.318000 | 0.580000 | 1.33e-02 | 2.28e-01 | 2.78e-02 | 5.89e-05 |
| Mitochondrial calcium ion transport | 21 | 7.14e-05 | 3.39e-04 | 0.7720 | -0.598000 | -0.011100 | -0.338000 | -0.351000 | 2.12e-06 | 9.30e-01 | 7.32e-03 | 5.33e-03 |
| MET activates PTK2 signaling | 14 | 3.31e-04 | 1.31e-03 | 0.7690 | 0.587000 | -0.431000 | 0.036100 | 0.244000 | 1.44e-04 | 5.24e-03 | 8.15e-01 | 1.14e-01 |
| Acyl chain remodelling of PS | 10 | 1.23e-02 | 2.79e-02 | 0.7670 | 0.414000 | 0.218000 | 0.215000 | 0.568000 | 2.33e-02 | 2.34e-01 | 2.38e-01 | 1.86e-03 |
| Voltage gated Potassium channels | 11 | 1.04e-03 | 3.54e-03 | 0.7670 | 0.212000 | -0.528000 | -0.361000 | -0.365000 | 2.23e-01 | 2.43e-03 | 3.80e-02 | 3.59e-02 |
| Mitochondrial translation | 87 | 1.59e-19 | 1.02e-17 | 0.7640 | -0.554000 | 0.159000 | -0.315000 | -0.389000 | 4.10e-19 | 1.07e-02 | 4.08e-07 | 3.59e-10 |
| Syndecan interactions | 17 | 1.45e-03 | 4.64e-03 | 0.7610 | 0.544000 | -0.048400 | 0.357000 | 0.392000 | 1.04e-04 | 7.30e-01 | 1.08e-02 | 5.21e-03 |
| N-Glycan antennae elongation | 12 | 6.08e-03 | 1.56e-02 | 0.7590 | 0.262000 | -0.260000 | 0.429000 | 0.505000 | 1.16e-01 | 1.18e-01 | 1.00e-02 | 2.47e-03 |
| Other interleukin signaling | 13 | 7.41e-03 | 1.84e-02 | 0.7570 | 0.554000 | -0.131000 | 0.267000 | 0.421000 | 5.43e-04 | 4.12e-01 | 9.55e-02 | 8.60e-03 |
| Biotin transport and metabolism | 10 | 3.96e-02 | 7.50e-02 | 0.7570 | -0.323000 | -0.020100 | -0.535000 | -0.426000 | 7.66e-02 | 9.12e-01 | 3.39e-03 | 1.98e-02 |
| Mitochondrial translation termination | 81 | 1.65e-17 | 8.47e-16 | 0.7540 | -0.538000 | 0.156000 | -0.293000 | -0.411000 | 5.73e-17 | 1.52e-02 | 5.20e-06 | 1.77e-10 |
| Mitochondrial translation elongation | 81 | 1.59e-17 | 8.47e-16 | 0.7530 | -0.542000 | 0.159000 | -0.297000 | -0.399000 | 3.57e-17 | 1.37e-02 | 3.81e-06 | 5.70e-10 |
| Gluconeogenesis | 21 | 1.67e-05 | 9.17e-05 | 0.7490 | -0.070100 | -0.555000 | -0.352000 | -0.352000 | 5.78e-01 | 1.06e-05 | 5.28e-03 | 5.23e-03 |
| Integrin cell surface interactions | 45 | 1.02e-11 | 1.98e-10 | 0.7480 | 0.599000 | -0.231000 | 0.096500 | 0.372000 | 3.67e-12 | 7.31e-03 | 2.63e-01 | 1.63e-05 |
| CS/DS degradation | 10 | 2.00e-02 | 4.18e-02 | 0.7460 | 0.474000 | -0.265000 | 0.163000 | 0.485000 | 9.43e-03 | 1.47e-01 | 3.72e-01 | 7.89e-03 |
| Sema3A PAK dependent Axon repulsion | 15 | 3.33e-03 | 9.54e-03 | 0.7460 | 0.315000 | -0.183000 | 0.392000 | 0.520000 | 3.46e-02 | 2.20e-01 | 8.57e-03 | 4.95e-04 |
| Phase 0 - rapid depolarisation | 17 | 7.93e-05 | 3.75e-04 | 0.7460 | -0.074000 | -0.622000 | -0.260000 | -0.310000 | 5.98e-01 | 8.98e-06 | 6.35e-02 | 2.69e-02 |
| Chondroitin sulfate/dermatan sulfate metabolism | 37 | 1.73e-08 | 1.82e-07 | 0.7440 | 0.566000 | -0.226000 | 0.194000 | 0.380000 | 2.58e-09 | 1.73e-02 | 4.15e-02 | 6.48e-05 |
| Elastic fibre formation | 34 | 1.94e-07 | 1.82e-06 | 0.7430 | 0.588000 | -0.040500 | 0.280000 | 0.356000 | 2.98e-09 | 6.83e-01 | 4.82e-03 | 3.36e-04 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 14 | 5.36e-03 | 1.41e-02 | 0.7430 | 0.441000 | -0.215000 | 0.257000 | 0.495000 | 4.32e-03 | 1.63e-01 | 9.67e-02 | 1.34e-03 |
| Regulation of Complement cascade | 13 | 3.47e-04 | 1.36e-03 | 0.7410 | 0.652000 | 0.047400 | -0.009540 | 0.348000 | 4.68e-05 | 7.67e-01 | 9.53e-01 | 2.97e-02 |
| Mitochondrial translation initiation | 81 | 4.72e-17 | 2.15e-15 | 0.7400 | -0.540000 | 0.152000 | -0.291000 | -0.385000 | 4.46e-17 | 1.84e-02 | 6.38e-06 | 2.12e-09 |
| Formation of tubulin folding intermediates by CCT/TriC | 17 | 1.34e-05 | 7.63e-05 | 0.7390 | 0.075600 | -0.094600 | 0.683000 | 0.255000 | 5.89e-01 | 5.00e-01 | 1.07e-06 | 6.91e-02 |
| Binding and Uptake of Ligands by Scavenger Receptors | 23 | 3.26e-05 | 1.67e-04 | 0.7370 | 0.555000 | -0.152000 | 0.157000 | 0.433000 | 4.15e-06 | 2.08e-01 | 1.92e-01 | 3.30e-04 |
| tRNA processing in the mitochondrion | 11 | 1.28e-02 | 2.88e-02 | 0.7360 | -0.616000 | 0.021400 | -0.259000 | -0.307000 | 4.00e-04 | 9.02e-01 | 1.37e-01 | 7.80e-02 |
| Defects in vitamin and cofactor metabolism | 17 | 1.55e-03 | 4.92e-03 | 0.7350 | -0.346000 | 0.105000 | -0.523000 | -0.368000 | 1.35e-02 | 4.52e-01 | 1.89e-04 | 8.64e-03 |
| Degradation of the extracellular matrix | 58 | 8.33e-14 | 2.38e-12 | 0.7340 | 0.540000 | -0.301000 | 0.141000 | 0.370000 | 1.11e-12 | 7.64e-05 | 6.28e-02 | 1.15e-06 |
| Regulation of IFNA signaling | 12 | 2.77e-02 | 5.51e-02 | 0.7320 | 0.419000 | -0.037800 | 0.345000 | 0.489000 | 1.19e-02 | 8.21e-01 | 3.85e-02 | 3.35e-03 |
| Metabolism of steroid hormones | 12 | 9.82e-03 | 2.32e-02 | 0.7320 | 0.218000 | -0.117000 | 0.387000 | 0.569000 | 1.90e-01 | 4.85e-01 | 2.02e-02 | 6.42e-04 |
| Interleukin-4 and Interleukin-13 signaling | 64 | 4.20e-12 | 9.07e-11 | 0.7310 | 0.428000 | -0.130000 | 0.401000 | 0.416000 | 3.24e-09 | 7.28e-02 | 2.88e-08 | 8.56e-09 |
| ECM proteoglycans | 37 | 9.76e-09 | 1.12e-07 | 0.7300 | 0.569000 | -0.270000 | 0.143000 | 0.341000 | 2.08e-09 | 4.58e-03 | 1.33e-01 | 3.40e-04 |
| Collagen biosynthesis and modifying enzymes | 47 | 3.12e-11 | 5.48e-10 | 0.7290 | 0.500000 | -0.352000 | 0.117000 | 0.379000 | 3.16e-09 | 3.02e-05 | 1.67e-01 | 7.07e-06 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 12 | 1.16e-02 | 2.66e-02 | 0.7260 | 0.274000 | -0.193000 | 0.503000 | 0.403000 | 1.00e-01 | 2.47e-01 | 2.57e-03 | 1.58e-02 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 10 | 6.13e-02 | 1.06e-01 | 0.7250 | -0.386000 | -0.141000 | -0.468000 | -0.371000 | 3.44e-02 | 4.42e-01 | 1.05e-02 | 4.20e-02 |
| Laminin interactions | 19 | 1.99e-05 | 1.07e-04 | 0.7240 | 0.575000 | -0.344000 | -0.060300 | 0.268000 | 1.44e-05 | 9.38e-03 | 6.49e-01 | 4.34e-02 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 11 | 1.14e-02 | 2.64e-02 | 0.7230 | 0.537000 | -0.360000 | 0.162000 | 0.280000 | 2.04e-03 | 3.89e-02 | 3.52e-01 | 1.08e-01 |
| Defective EXT2 causes exostoses 2 | 11 | 1.14e-02 | 2.64e-02 | 0.7230 | 0.537000 | -0.360000 | 0.162000 | 0.280000 | 2.04e-03 | 3.89e-02 | 3.52e-01 | 1.08e-01 |
| rRNA modification in the nucleus and cytosol | 52 | 1.28e-15 | 4.91e-14 | 0.7220 | -0.181000 | 0.601000 | 0.357000 | 0.011000 | 2.44e-02 | 6.53e-14 | 8.81e-06 | 8.91e-01 |
| RHO GTPases Activate WASPs and WAVEs | 31 | 2.90e-05 | 1.49e-04 | 0.7180 | 0.362000 | 0.090600 | 0.428000 | 0.440000 | 4.85e-04 | 3.83e-01 | 3.82e-05 | 2.24e-05 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 10 | 9.89e-04 | 3.37e-03 | 0.7170 | 0.114000 | -0.245000 | 0.050400 | 0.662000 | 5.32e-01 | 1.80e-01 | 7.82e-01 | 2.88e-04 |
| FCGR3A-mediated phagocytosis | 47 | 5.38e-08 | 5.42e-07 | 0.7130 | 0.384000 | -0.011900 | 0.377000 | 0.467000 | 5.20e-06 | 8.88e-01 | 8.09e-06 | 3.05e-08 |
| Leishmania phagocytosis | 47 | 5.38e-08 | 5.42e-07 | 0.7130 | 0.384000 | -0.011900 | 0.377000 | 0.467000 | 5.20e-06 | 8.88e-01 | 8.09e-06 | 3.05e-08 |
| Parasite infection | 47 | 5.38e-08 | 5.42e-07 | 0.7130 | 0.384000 | -0.011900 | 0.377000 | 0.467000 | 5.20e-06 | 8.88e-01 | 8.09e-06 | 3.05e-08 |
| Cristae formation | 10 | 5.76e-02 | 1.02e-01 | 0.7120 | -0.512000 | 0.050200 | -0.293000 | -0.395000 | 5.03e-03 | 7.84e-01 | 1.09e-01 | 3.04e-02 |
| Collagen formation | 63 | 7.69e-15 | 2.62e-13 | 0.7110 | 0.507000 | -0.309000 | 0.080700 | 0.383000 | 3.43e-12 | 2.29e-05 | 2.69e-01 | 1.45e-07 |
| Extracellular matrix organization | 192 | 7.97e-44 | 3.27e-41 | 0.7110 | 0.545000 | -0.258000 | 0.142000 | 0.348000 | 9.51e-39 | 8.04e-10 | 7.16e-04 | 1.07e-16 |
| Glycogen storage diseases | 11 | 2.64e-03 | 7.75e-03 | 0.7090 | -0.370000 | -0.407000 | -0.060700 | -0.443000 | 3.38e-02 | 1.95e-02 | 7.27e-01 | 1.09e-02 |
| Diseases associated with glycosaminoglycan metabolism | 30 | 1.97e-06 | 1.41e-05 | 0.7080 | 0.565000 | -0.217000 | 0.193000 | 0.311000 | 8.36e-08 | 3.97e-02 | 6.70e-02 | 3.26e-03 |
| Condensation of Prophase Chromosomes | 11 | 6.32e-04 | 2.24e-03 | 0.7060 | -0.153000 | 0.373000 | 0.188000 | 0.548000 | 3.80e-01 | 3.21e-02 | 2.79e-01 | 1.67e-03 |
| Postmitotic nuclear pore complex (NPC) reformation | 24 | 1.70e-06 | 1.23e-05 | 0.7050 | -0.187000 | 0.544000 | 0.351000 | 0.208000 | 1.14e-01 | 4.01e-06 | 2.97e-03 | 7.72e-02 |
| Processing of SMDT1 | 15 | 2.49e-03 | 7.38e-03 | 0.7030 | -0.584000 | 0.149000 | -0.268000 | -0.244000 | 9.01e-05 | 3.18e-01 | 7.29e-02 | 1.01e-01 |
| GPVI-mediated activation cascade | 18 | 3.88e-03 | 1.09e-02 | 0.7010 | 0.235000 | 0.160000 | 0.461000 | 0.444000 | 8.40e-02 | 2.41e-01 | 7.03e-04 | 1.11e-03 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 10 | 4.97e-02 | 9.06e-02 | 0.7000 | -0.198000 | -0.379000 | -0.426000 | -0.356000 | 2.78e-01 | 3.82e-02 | 1.98e-02 | 5.12e-02 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 34 | 3.73e-07 | 3.32e-06 | 0.6950 | 0.537000 | -0.272000 | 0.173000 | 0.300000 | 5.94e-08 | 6.01e-03 | 8.04e-02 | 2.48e-03 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 65 | 2.15e-13 | 5.63e-12 | 0.6940 | 0.557000 | -0.093700 | 0.169000 | 0.367000 | 8.07e-15 | 1.92e-01 | 1.88e-02 | 3.29e-07 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | 20 | 6.74e-05 | 3.22e-04 | 0.6890 | 0.179000 | -0.422000 | 0.311000 | 0.409000 | 1.67e-01 | 1.08e-03 | 1.62e-02 | 1.55e-03 |
| Assembly of collagen fibrils and other multimeric structures | 42 | 4.73e-10 | 6.68e-09 | 0.6880 | 0.506000 | -0.284000 | 0.002670 | 0.370000 | 1.42e-08 | 1.46e-03 | 9.76e-01 | 3.32e-05 |
| Synthesis of bile acids and bile salts | 18 | 7.00e-03 | 1.76e-02 | 0.6870 | -0.392000 | -0.098600 | -0.395000 | -0.391000 | 4.00e-03 | 4.69e-01 | 3.70e-03 | 4.13e-03 |
| Heme biosynthesis | 12 | 1.48e-02 | 3.23e-02 | 0.6860 | -0.132000 | -0.127000 | -0.580000 | -0.317000 | 4.29e-01 | 4.45e-01 | 4.99e-04 | 5.77e-02 |
| Post-translational protein phosphorylation | 62 | 4.30e-12 | 9.12e-11 | 0.6860 | 0.543000 | -0.078400 | 0.187000 | 0.367000 | 1.48e-13 | 2.87e-01 | 1.10e-02 | 5.90e-07 |
| p130Cas linkage to MAPK signaling for integrins | 10 | 1.29e-02 | 2.89e-02 | 0.6860 | 0.400000 | -0.141000 | 0.520000 | 0.140000 | 2.85e-02 | 4.39e-01 | 4.42e-03 | 4.42e-01 |
| Plasma lipoprotein remodeling | 11 | 8.59e-03 | 2.09e-02 | 0.6820 | 0.507000 | -0.282000 | -0.051100 | 0.355000 | 3.62e-03 | 1.06e-01 | 7.69e-01 | 4.17e-02 |
| Striated Muscle Contraction | 30 | 1.01e-07 | 9.91e-07 | 0.6800 | 0.030300 | -0.602000 | -0.187000 | -0.254000 | 7.74e-01 | 1.15e-08 | 7.60e-02 | 1.62e-02 |
| CRMPs in Sema3A signaling | 12 | 3.79e-02 | 7.27e-02 | 0.6800 | 0.363000 | -0.202000 | 0.335000 | 0.422000 | 2.97e-02 | 2.26e-01 | 4.47e-02 | 1.14e-02 |
| LDL clearance | 14 | 8.58e-03 | 2.09e-02 | 0.6750 | 0.305000 | 0.023000 | 0.219000 | 0.561000 | 4.82e-02 | 8.81e-01 | 1.56e-01 | 2.83e-04 |
| Retinoid metabolism and transport | 19 | 1.61e-03 | 5.04e-03 | 0.6710 | 0.372000 | -0.262000 | 0.205000 | 0.449000 | 5.01e-03 | 4.81e-02 | 1.23e-01 | 7.08e-04 |
| Class A/1 (Rhodopsin-like receptors) | 38 | 3.05e-07 | 2.73e-06 | 0.6710 | 0.557000 | -0.069400 | 0.233000 | 0.284000 | 2.86e-09 | 4.60e-01 | 1.32e-02 | 2.49e-03 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 10 | 6.38e-02 | 1.09e-01 | 0.6700 | 0.212000 | 0.109000 | 0.540000 | 0.318000 | 2.46e-01 | 5.49e-01 | 3.12e-03 | 8.18e-02 |
| Transport of the SLBP Dependant Mature mRNA | 29 | 6.43e-07 | 5.41e-06 | 0.6670 | -0.141000 | 0.557000 | 0.307000 | 0.144000 | 1.89e-01 | 2.11e-07 | 4.18e-03 | 1.78e-01 |
| Mitochondrial protein import | 55 | 7.63e-09 | 8.85e-08 | 0.6660 | -0.477000 | -0.007500 | -0.288000 | -0.365000 | 9.51e-10 | 9.23e-01 | 2.27e-04 | 2.92e-06 |
| TNFR1-induced proapoptotic signaling | 11 | 4.27e-02 | 7.99e-02 | 0.6640 | 0.383000 | -0.322000 | 0.254000 | 0.354000 | 2.78e-02 | 6.44e-02 | 1.45e-01 | 4.21e-02 |
| Metabolism of non-coding RNA | 45 | 2.13e-11 | 3.80e-10 | 0.6630 | -0.273000 | 0.557000 | 0.236000 | -0.010100 | 1.57e-03 | 1.03e-10 | 6.24e-03 | 9.06e-01 |
| snRNP Assembly | 45 | 2.13e-11 | 3.80e-10 | 0.6630 | -0.273000 | 0.557000 | 0.236000 | -0.010100 | 1.57e-03 | 1.03e-10 | 6.24e-03 | 9.06e-01 |
| NCAM1 interactions | 21 | 3.48e-05 | 1.77e-04 | 0.6620 | 0.367000 | -0.486000 | -0.142000 | 0.215000 | 3.60e-03 | 1.15e-04 | 2.61e-01 | 8.76e-02 |
| Unwinding of DNA | 10 | 5.90e-02 | 1.04e-01 | 0.6590 | 0.135000 | -0.035000 | 0.473000 | 0.436000 | 4.59e-01 | 8.48e-01 | 9.56e-03 | 1.70e-02 |
| N-glycan antennae elongation in the medial/trans-Golgi | 17 | 5.80e-03 | 1.50e-02 | 0.6580 | 0.239000 | -0.124000 | 0.339000 | 0.496000 | 8.88e-02 | 3.77e-01 | 1.55e-02 | 3.96e-04 |
| Transport of the SLBP independent Mature mRNA | 28 | 1.53e-06 | 1.13e-05 | 0.6570 | -0.155000 | 0.557000 | 0.285000 | 0.128000 | 1.56e-01 | 3.43e-07 | 9.14e-03 | 2.41e-01 |
| Defective B3GALTL causes Peters-plus syndrome (PpS) | 23 | 7.57e-06 | 4.68e-05 | 0.6560 | 0.455000 | -0.187000 | -0.082700 | 0.426000 | 1.58e-04 | 1.21e-01 | 4.92e-01 | 4.06e-04 |
| Regulation of actin dynamics for phagocytic cup formation | 49 | 3.88e-07 | 3.43e-06 | 0.6550 | 0.309000 | -0.022400 | 0.373000 | 0.440000 | 1.85e-04 | 7.86e-01 | 6.21e-06 | 1.02e-07 |
| O-glycosylation of TSR domain-containing proteins | 24 | 8.56e-06 | 5.18e-05 | 0.6550 | 0.459000 | -0.186000 | -0.053900 | 0.424000 | 9.87e-05 | 1.14e-01 | 6.48e-01 | 3.21e-04 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 20 | 5.18e-03 | 1.37e-02 | 0.6540 | -0.374000 | -0.168000 | -0.378000 | -0.342000 | 3.79e-03 | 1.94e-01 | 3.45e-03 | 8.09e-03 |
| Transport of Ribonucleoproteins into the Host Nucleus | 25 | 5.49e-06 | 3.55e-05 | 0.6530 | -0.227000 | 0.542000 | 0.270000 | 0.095000 | 4.93e-02 | 2.75e-06 | 1.97e-02 | 4.11e-01 |
| Leading Strand Synthesis | 14 | 5.61e-03 | 1.45e-02 | 0.6520 | -0.014900 | 0.228000 | 0.392000 | 0.469000 | 9.23e-01 | 1.40e-01 | 1.12e-02 | 2.40e-03 |
| Polymerase switching | 14 | 5.61e-03 | 1.45e-02 | 0.6520 | -0.014900 | 0.228000 | 0.392000 | 0.469000 | 9.23e-01 | 1.40e-01 | 1.12e-02 | 2.40e-03 |
| Collagen chain trimerization | 31 | 1.13e-06 | 8.69e-06 | 0.6510 | 0.464000 | -0.306000 | -0.010700 | 0.340000 | 7.92e-06 | 3.21e-03 | 9.18e-01 | 1.06e-03 |
| Sulfur amino acid metabolism | 21 | 1.14e-03 | 3.78e-03 | 0.6500 | -0.298000 | -0.196000 | -0.236000 | -0.490000 | 1.83e-02 | 1.20e-01 | 6.16e-02 | 1.01e-04 |
| Effects of PIP2 hydrolysis | 19 | 1.66e-05 | 9.15e-05 | 0.6490 | 0.375000 | -0.324000 | -0.389000 | -0.155000 | 4.62e-03 | 1.46e-02 | 3.37e-03 | 2.43e-01 |
| Transcriptional activation of mitochondrial biogenesis | 47 | 1.58e-06 | 1.16e-05 | 0.6470 | -0.373000 | -0.044800 | -0.375000 | -0.370000 | 9.99e-06 | 5.96e-01 | 8.80e-06 | 1.17e-05 |
| Mitochondrial biogenesis | 66 | 3.45e-09 | 4.24e-08 | 0.6470 | -0.368000 | -0.070800 | -0.363000 | -0.382000 | 2.34e-07 | 3.21e-01 | 3.54e-07 | 8.26e-08 |
| Nuclear import of Rev protein | 26 | 5.46e-06 | 3.55e-05 | 0.6460 | -0.187000 | 0.534000 | 0.275000 | 0.148000 | 9.87e-02 | 2.45e-06 | 1.53e-02 | 1.91e-01 |
| EPHB-mediated forward signaling | 32 | 1.73e-04 | 7.34e-04 | 0.6460 | 0.401000 | 0.019900 | 0.322000 | 0.390000 | 8.58e-05 | 8.46e-01 | 1.63e-03 | 1.34e-04 |
| SUMOylation of SUMOylation proteins | 27 | 3.01e-06 | 2.05e-05 | 0.6440 | -0.211000 | 0.543000 | 0.254000 | 0.104000 | 5.76e-02 | 1.04e-06 | 2.26e-02 | 3.51e-01 |
| Export of Viral Ribonucleoproteins from Nucleus | 26 | 7.57e-06 | 4.68e-05 | 0.6430 | -0.163000 | 0.543000 | 0.275000 | 0.129000 | 1.51e-01 | 1.64e-06 | 1.54e-02 | 2.55e-01 |
| Interactions of Rev with host cellular proteins | 29 | 2.59e-06 | 1.80e-05 | 0.6360 | -0.153000 | 0.499000 | 0.318000 | 0.176000 | 1.55e-01 | 3.30e-06 | 3.02e-03 | 1.00e-01 |
| Keratinization | 11 | 2.86e-02 | 5.64e-02 | 0.6350 | 0.369000 | -0.395000 | 0.270000 | 0.196000 | 3.42e-02 | 2.33e-02 | 1.21e-01 | 2.61e-01 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 23 | 3.50e-05 | 1.77e-04 | 0.6350 | -0.202000 | 0.539000 | 0.235000 | 0.127000 | 9.31e-02 | 7.62e-06 | 5.09e-02 | 2.91e-01 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | 23 | 3.50e-05 | 1.77e-04 | 0.6350 | -0.202000 | 0.539000 | 0.235000 | 0.127000 | 9.31e-02 | 7.62e-06 | 5.09e-02 | 2.91e-01 |
| SUMOylation of DNA replication proteins | 35 | 2.18e-07 | 2.03e-06 | 0.6340 | -0.114000 | 0.499000 | 0.316000 | 0.200000 | 2.44e-01 | 3.19e-07 | 1.21e-03 | 4.08e-02 |
| NGF-stimulated transcription | 30 | 1.25e-05 | 7.20e-05 | 0.6340 | 0.349000 | -0.032200 | 0.493000 | 0.188000 | 9.32e-04 | 7.61e-01 | 2.98e-06 | 7.42e-02 |
| Non-integrin membrane-ECM interactions | 35 | 1.28e-06 | 9.57e-06 | 0.6340 | 0.503000 | -0.281000 | 0.093700 | 0.246000 | 2.60e-07 | 4.08e-03 | 3.38e-01 | 1.18e-02 |
| Glycogen breakdown (glycogenolysis) | 14 | 7.44e-03 | 1.85e-02 | 0.6320 | -0.110000 | -0.537000 | -0.259000 | -0.177000 | 4.77e-01 | 4.99e-04 | 9.37e-02 | 2.52e-01 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 19 | 5.42e-03 | 1.42e-02 | 0.6320 | 0.209000 | -0.095900 | 0.377000 | 0.452000 | 1.15e-01 | 4.69e-01 | 4.43e-03 | 6.58e-04 |
| Zinc transporters | 11 | 6.20e-02 | 1.07e-01 | 0.6310 | 0.372000 | 0.304000 | 0.288000 | 0.290000 | 3.25e-02 | 8.10e-02 | 9.85e-02 | 9.64e-02 |
| Signaling by NODAL | 10 | 4.99e-02 | 9.06e-02 | 0.6290 | -0.322000 | -0.167000 | -0.136000 | -0.495000 | 7.81e-02 | 3.59e-01 | 4.57e-01 | 6.69e-03 |
| Vpr-mediated nuclear import of PICs | 27 | 4.06e-06 | 2.71e-05 | 0.6280 | -0.252000 | 0.493000 | 0.286000 | 0.080800 | 2.35e-02 | 9.44e-06 | 1.01e-02 | 4.68e-01 |
| EPH-ephrin mediated repulsion of cells | 37 | 8.71e-06 | 5.22e-05 | 0.6260 | 0.426000 | -0.125000 | 0.162000 | 0.411000 | 7.56e-06 | 1.89e-01 | 8.78e-02 | 1.51e-05 |
| Peroxisomal protein import | 49 | 7.97e-07 | 6.44e-06 | 0.6240 | -0.414000 | -0.116000 | -0.319000 | -0.320000 | 5.45e-07 | 1.60e-01 | 1.15e-04 | 1.06e-04 |
| TP53 Regulates Transcription of Death Receptors and Ligands | 11 | 4.10e-02 | 7.73e-02 | 0.6230 | 0.546000 | -0.007260 | 0.152000 | 0.259000 | 1.71e-03 | 9.67e-01 | 3.83e-01 | 1.37e-01 |
| NEP/NS2 Interacts with the Cellular Export Machinery | 25 | 2.17e-05 | 1.15e-04 | 0.6230 | -0.194000 | 0.526000 | 0.245000 | 0.119000 | 9.40e-02 | 5.39e-06 | 3.37e-02 | 3.03e-01 |
| Carboxyterminal post-translational modifications of tubulin | 21 | 8.96e-04 | 3.09e-03 | 0.6220 | 0.472000 | -0.153000 | 0.063800 | 0.370000 | 1.83e-04 | 2.26e-01 | 6.13e-01 | 3.34e-03 |
| SUMOylation of ubiquitinylation proteins | 31 | 2.25e-06 | 1.60e-05 | 0.6190 | -0.127000 | 0.530000 | 0.270000 | 0.111000 | 2.22e-01 | 3.21e-07 | 9.23e-03 | 2.86e-01 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 10 | 3.71e-02 | 7.15e-02 | 0.6180 | 0.345000 | -0.202000 | 0.449000 | 0.144000 | 5.92e-02 | 2.69e-01 | 1.39e-02 | 4.31e-01 |
| Peptide ligand-binding receptors | 22 | 9.19e-04 | 3.16e-03 | 0.6170 | 0.530000 | -0.071400 | 0.195000 | 0.238000 | 1.67e-05 | 5.63e-01 | 1.14e-01 | 5.36e-02 |
| Rev-mediated nuclear export of HIV RNA | 28 | 1.15e-05 | 6.68e-05 | 0.6170 | -0.133000 | 0.490000 | 0.306000 | 0.170000 | 2.22e-01 | 7.09e-06 | 5.13e-03 | 1.21e-01 |
| RORA activates gene expression | 17 | 2.33e-02 | 4.77e-02 | 0.6140 | -0.385000 | -0.105000 | -0.360000 | -0.297000 | 6.00e-03 | 4.52e-01 | 1.02e-02 | 3.38e-02 |
| mRNA Splicing - Major Pathway | 161 | 7.65e-37 | 1.57e-34 | 0.6120 | -0.148000 | 0.509000 | 0.300000 | -0.059500 | 1.26e-03 | 8.41e-29 | 6.11e-11 | 1.95e-01 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 17 | 2.24e-02 | 4.61e-02 | 0.6120 | 0.266000 | 0.229000 | 0.316000 | 0.389000 | 5.76e-02 | 1.02e-01 | 2.43e-02 | 5.52e-03 |
| Complement cascade | 14 | 4.23e-03 | 1.17e-02 | 0.6090 | 0.534000 | -0.008580 | -0.029600 | 0.291000 | 5.37e-04 | 9.56e-01 | 8.48e-01 | 5.97e-02 |
| Mitotic Telophase/Cytokinesis | 10 | 5.08e-02 | 9.19e-02 | 0.6090 | -0.386000 | 0.399000 | -0.204000 | -0.145000 | 3.45e-02 | 2.90e-02 | 2.65e-01 | 4.28e-01 |
| Molecules associated with elastic fibres | 25 | 5.00e-04 | 1.87e-03 | 0.6050 | 0.509000 | 0.033400 | 0.190000 | 0.264000 | 1.06e-05 | 7.73e-01 | 1.00e-01 | 2.24e-02 |
| ADP signalling through P2Y purinoceptor 12 | 13 | 1.11e-02 | 2.60e-02 | 0.6030 | 0.518000 | 0.048400 | 0.020800 | 0.305000 | 1.23e-03 | 7.62e-01 | 8.97e-01 | 5.66e-02 |
| G-protein activation | 13 | 1.11e-02 | 2.60e-02 | 0.6030 | 0.518000 | 0.048400 | 0.020800 | 0.305000 | 1.23e-03 | 7.62e-01 | 8.97e-01 | 5.66e-02 |
| mRNA Splicing | 169 | 1.11e-37 | 2.73e-35 | 0.6020 | -0.161000 | 0.501000 | 0.283000 | -0.074400 | 3.36e-04 | 2.87e-29 | 2.52e-10 | 9.66e-02 |
| Interactions of Vpr with host cellular proteins | 29 | 5.45e-06 | 3.55e-05 | 0.6020 | -0.228000 | 0.477000 | 0.280000 | 0.073100 | 3.37e-02 | 8.95e-06 | 9.19e-03 | 4.96e-01 |
| Synaptic adhesion-like molecules | 12 | 1.75e-02 | 3.75e-02 | 0.6020 | 0.448000 | -0.343000 | -0.078200 | 0.194000 | 7.20e-03 | 3.94e-02 | 6.39e-01 | 2.45e-01 |
| Cell surface interactions at the vascular wall | 71 | 1.78e-10 | 2.80e-09 | 0.6010 | 0.355000 | -0.262000 | 0.190000 | 0.361000 | 2.36e-07 | 1.39e-04 | 5.61e-03 | 1.51e-07 |
| RIP-mediated NFkB activation via ZBP1 | 14 | 4.38e-02 | 8.15e-02 | 0.6000 | 0.149000 | 0.076800 | 0.361000 | 0.449000 | 3.34e-01 | 6.19e-01 | 1.94e-02 | 3.63e-03 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | 59 | 3.66e-12 | 8.10e-11 | 0.6000 | -0.124000 | 0.527000 | 0.258000 | -0.020900 | 9.97e-02 | 2.61e-12 | 6.23e-04 | 7.82e-01 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 11 | 4.84e-02 | 8.88e-02 | 0.5980 | 0.000527 | 0.201000 | 0.497000 | 0.264000 | 9.98e-01 | 2.49e-01 | 4.32e-03 | 1.30e-01 |
| EPHA-mediated growth cone collapse | 13 | 5.06e-02 | 9.17e-02 | 0.5970 | 0.435000 | -0.103000 | 0.325000 | 0.226000 | 6.57e-03 | 5.21e-01 | 4.23e-02 | 1.59e-01 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | 11 | 7.70e-02 | 1.28e-01 | 0.5970 | -0.299000 | 0.149000 | -0.430000 | -0.243000 | 8.57e-02 | 3.91e-01 | 1.35e-02 | 1.63e-01 |
| Processing of Capped Intron-Containing Pre-mRNA | 211 | 1.05e-45 | 6.43e-43 | 0.5960 | -0.154000 | 0.502000 | 0.274000 | -0.065400 | 1.24e-04 | 3.59e-36 | 8.70e-12 | 1.04e-01 |
| Formation of Fibrin Clot (Clotting Cascade) | 13 | 3.48e-02 | 6.79e-02 | 0.5960 | 0.471000 | 0.073000 | 0.127000 | 0.334000 | 3.30e-03 | 6.49e-01 | 4.29e-01 | 3.69e-02 |
| EPH-Ephrin signaling | 75 | 2.25e-09 | 2.88e-08 | 0.5950 | 0.396000 | -0.083300 | 0.274000 | 0.340000 | 3.10e-09 | 2.13e-01 | 4.17e-05 | 3.80e-07 |
| ZBP1(DAI) mediated induction of type I IFNs | 17 | 2.16e-02 | 4.47e-02 | 0.5950 | 0.195000 | 0.095400 | 0.307000 | 0.461000 | 1.65e-01 | 4.96e-01 | 2.86e-02 | 1.01e-03 |
| HIV Transcription Initiation | 40 | 1.16e-08 | 1.25e-07 | 0.5930 | -0.206000 | 0.453000 | 0.313000 | -0.075200 | 2.45e-02 | 7.25e-07 | 6.17e-04 | 4.11e-01 |
| RNA Polymerase II HIV Promoter Escape | 40 | 1.16e-08 | 1.25e-07 | 0.5930 | -0.206000 | 0.453000 | 0.313000 | -0.075200 | 2.45e-02 | 7.25e-07 | 6.17e-04 | 4.11e-01 |
| RNA Polymerase II Promoter Escape | 40 | 1.16e-08 | 1.25e-07 | 0.5930 | -0.206000 | 0.453000 | 0.313000 | -0.075200 | 2.45e-02 | 7.25e-07 | 6.17e-04 | 4.11e-01 |
| RNA Polymerase II Transcription Initiation | 40 | 1.16e-08 | 1.25e-07 | 0.5930 | -0.206000 | 0.453000 | 0.313000 | -0.075200 | 2.45e-02 | 7.25e-07 | 6.17e-04 | 4.11e-01 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | 40 | 1.16e-08 | 1.25e-07 | 0.5930 | -0.206000 | 0.453000 | 0.313000 | -0.075200 | 2.45e-02 | 7.25e-07 | 6.17e-04 | 4.11e-01 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 40 | 1.16e-08 | 1.25e-07 | 0.5930 | -0.206000 | 0.453000 | 0.313000 | -0.075200 | 2.45e-02 | 7.25e-07 | 6.17e-04 | 4.11e-01 |
| p75NTR signals via NF-kB | 13 | 4.76e-02 | 8.76e-02 | 0.5920 | 0.292000 | 0.002260 | 0.465000 | 0.222000 | 6.87e-02 | 9.89e-01 | 3.71e-03 | 1.66e-01 |
| Activation of SMO | 12 | 1.13e-02 | 2.63e-02 | 0.5890 | 0.512000 | -0.189000 | -0.115000 | 0.190000 | 2.16e-03 | 2.58e-01 | 4.91e-01 | 2.55e-01 |
| Viral Messenger RNA Synthesis | 35 | 1.12e-06 | 8.69e-06 | 0.5890 | -0.170000 | 0.467000 | 0.295000 | 0.112000 | 8.26e-02 | 1.78e-06 | 2.52e-03 | 2.51e-01 |
| Caspase-mediated cleavage of cytoskeletal proteins | 11 | 1.14e-01 | 1.75e-01 | 0.5830 | 0.359000 | -0.257000 | 0.239000 | 0.297000 | 3.90e-02 | 1.40e-01 | 1.71e-01 | 8.86e-02 |
| ABC transporters in lipid homeostasis | 11 | 5.74e-03 | 1.48e-02 | 0.5820 | 0.063300 | -0.122000 | -0.566000 | -0.004480 | 7.16e-01 | 4.82e-01 | 1.16e-03 | 9.79e-01 |
| Nuclear Receptor transcription pathway | 37 | 2.08e-05 | 1.11e-04 | 0.5800 | -0.304000 | -0.341000 | -0.274000 | -0.229000 | 1.41e-03 | 3.39e-04 | 3.89e-03 | 1.62e-02 |
| Interaction between L1 and Ankyrins | 14 | 1.13e-02 | 2.63e-02 | 0.5790 | -0.043300 | -0.512000 | -0.268000 | -0.021900 | 7.79e-01 | 9.19e-04 | 8.31e-02 | 8.87e-01 |
| ROS and RNS production in phagocytes | 20 | 3.62e-03 | 1.02e-02 | 0.5790 | 0.172000 | -0.036200 | 0.224000 | 0.504000 | 1.83e-01 | 7.79e-01 | 8.28e-02 | 9.57e-05 |
| Thrombin signalling through proteinase activated receptors (PARs) | 20 | 1.25e-02 | 2.82e-02 | 0.5790 | 0.431000 | -0.049600 | 0.187000 | 0.334000 | 8.45e-04 | 7.01e-01 | 1.47e-01 | 9.82e-03 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | 36 | 1.49e-06 | 1.10e-05 | 0.5780 | -0.146000 | 0.469000 | 0.290000 | 0.091500 | 1.31e-01 | 1.12e-06 | 2.62e-03 | 3.43e-01 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | 11 | 2.13e-02 | 4.41e-02 | 0.5780 | -0.495000 | 0.239000 | -0.178000 | -0.019400 | 4.51e-03 | 1.70e-01 | 3.06e-01 | 9.11e-01 |
| Metabolism of fat-soluble vitamins | 22 | 4.60e-03 | 1.25e-02 | 0.5770 | 0.327000 | -0.235000 | 0.166000 | 0.379000 | 8.00e-03 | 5.69e-02 | 1.78e-01 | 2.07e-03 |
| Ephrin signaling | 18 | 1.65e-02 | 3.56e-02 | 0.5770 | 0.365000 | -0.192000 | 0.321000 | 0.244000 | 7.37e-03 | 1.59e-01 | 1.83e-02 | 7.34e-02 |
| Retrograde neurotrophin signalling | 11 | 1.07e-01 | 1.66e-01 | 0.5750 | 0.239000 | 0.022800 | 0.212000 | 0.478000 | 1.70e-01 | 8.96e-01 | 2.24e-01 | 6.03e-03 |
| RNA Polymerase II Pre-transcription Events | 69 | 6.15e-14 | 1.84e-12 | 0.5750 | -0.199000 | 0.433000 | 0.321000 | -0.025800 | 4.37e-03 | 5.24e-10 | 4.25e-06 | 7.11e-01 |
| Adrenaline,noradrenaline inhibits insulin secretion | 16 | 1.66e-03 | 5.16e-03 | 0.5730 | 0.506000 | -0.036900 | -0.104000 | 0.245000 | 4.56e-04 | 7.99e-01 | 4.73e-01 | 8.93e-02 |
| Long-term potentiation | 10 | 3.94e-02 | 7.49e-02 | 0.5730 | 0.080000 | -0.507000 | -0.093600 | -0.237000 | 6.61e-01 | 5.50e-03 | 6.09e-01 | 1.94e-01 |
| Class I peroxisomal membrane protein import | 20 | 2.63e-02 | 5.27e-02 | 0.5710 | -0.355000 | 0.040400 | -0.310000 | -0.320000 | 6.02e-03 | 7.55e-01 | 1.65e-02 | 1.33e-02 |
| Glycosaminoglycan metabolism | 80 | 3.64e-10 | 5.33e-09 | 0.5710 | 0.404000 | -0.144000 | 0.174000 | 0.334000 | 4.35e-10 | 2.59e-02 | 7.38e-03 | 2.56e-07 |
| Caspase activation via extrinsic apoptotic signalling pathway | 19 | 1.41e-02 | 3.10e-02 | 0.5700 | 0.310000 | -0.264000 | 0.212000 | 0.338000 | 1.93e-02 | 4.66e-02 | 1.10e-01 | 1.08e-02 |
| Transport of Mature Transcript to Cytoplasm | 68 | 8.92e-13 | 2.24e-11 | 0.5690 | -0.118000 | 0.485000 | 0.271000 | -0.026200 | 9.34e-02 | 4.56e-12 | 1.16e-04 | 7.09e-01 |
| Transport of Mature mRNA Derived from an Intronless Transcript | 35 | 3.41e-06 | 2.31e-05 | 0.5670 | -0.157000 | 0.467000 | 0.271000 | 0.076900 | 1.08e-01 | 1.80e-06 | 5.50e-03 | 4.31e-01 |
| Interferon gamma signaling | 43 | 7.99e-06 | 4.91e-05 | 0.5670 | 0.470000 | -0.040300 | 0.211000 | 0.235000 | 1.01e-07 | 6.48e-01 | 1.70e-02 | 7.69e-03 |
| Cardiac conduction | 60 | 2.02e-09 | 2.64e-08 | 0.5670 | -0.034600 | -0.459000 | -0.284000 | -0.168000 | 6.43e-01 | 7.70e-10 | 1.41e-04 | 2.45e-02 |
| HS-GAG biosynthesis | 18 | 1.18e-02 | 2.70e-02 | 0.5660 | 0.392000 | -0.292000 | 0.201000 | 0.204000 | 4.01e-03 | 3.22e-02 | 1.40e-01 | 1.34e-01 |
| Transcription of the HIV genome | 59 | 1.69e-11 | 3.19e-10 | 0.5660 | -0.177000 | 0.436000 | 0.310000 | -0.043800 | 1.86e-02 | 6.93e-09 | 3.91e-05 | 5.61e-01 |
| Regulation of KIT signaling | 14 | 4.86e-02 | 8.89e-02 | 0.5650 | 0.401000 | -0.224000 | 0.252000 | 0.212000 | 9.39e-03 | 1.47e-01 | 1.03e-01 | 1.70e-01 |
| Diseases associated with O-glycosylation of proteins | 32 | 1.51e-05 | 8.45e-05 | 0.5650 | 0.334000 | -0.220000 | -0.012700 | 0.399000 | 1.08e-03 | 3.15e-02 | 9.01e-01 | 9.44e-05 |
| Platelet degranulation | 86 | 7.46e-11 | 1.27e-09 | 0.5650 | 0.387000 | -0.142000 | 0.158000 | 0.352000 | 6.00e-10 | 2.30e-02 | 1.12e-02 | 1.72e-08 |
| AKT phosphorylates targets in the nucleus | 10 | 1.37e-01 | 2.00e-01 | 0.5650 | -0.219000 | -0.381000 | -0.282000 | -0.215000 | 2.30e-01 | 3.71e-02 | 1.23e-01 | 2.39e-01 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 15 | 3.50e-02 | 6.82e-02 | 0.5640 | 0.141000 | -0.125000 | 0.332000 | 0.415000 | 3.45e-01 | 4.04e-01 | 2.59e-02 | 5.35e-03 |
| NS1 Mediated Effects on Host Pathways | 31 | 2.17e-05 | 1.15e-04 | 0.5630 | -0.150000 | 0.452000 | 0.289000 | 0.077700 | 1.49e-01 | 1.33e-05 | 5.36e-03 | 4.54e-01 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 22 | 4.44e-04 | 1.68e-03 | 0.5610 | -0.015300 | 0.124000 | 0.520000 | 0.169000 | 9.01e-01 | 3.14e-01 | 2.39e-05 | 1.69e-01 |
| Smooth Muscle Contraction | 31 | 5.74e-07 | 4.86e-06 | 0.5590 | 0.250000 | -0.470000 | 0.133000 | -0.107000 | 1.63e-02 | 6.03e-06 | 1.99e-01 | 3.05e-01 |
| PINK1-PRKN Mediated Mitophagy | 17 | 1.39e-02 | 3.08e-02 | 0.5580 | -0.471000 | 0.134000 | -0.068000 | -0.259000 | 7.72e-04 | 3.40e-01 | 6.28e-01 | 6.43e-02 |
| Glycogen metabolism | 23 | 1.16e-03 | 3.82e-03 | 0.5580 | -0.245000 | -0.414000 | -0.167000 | -0.229000 | 4.24e-02 | 5.88e-04 | 1.66e-01 | 5.74e-02 |
| Keratan sulfate/keratin metabolism | 22 | 4.40e-03 | 1.20e-02 | 0.5550 | 0.263000 | -0.169000 | 0.146000 | 0.435000 | 3.26e-02 | 1.70e-01 | 2.38e-01 | 4.13e-04 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 13 | 5.45e-02 | 9.74e-02 | 0.5530 | 0.068300 | 0.008600 | 0.322000 | 0.444000 | 6.70e-01 | 9.57e-01 | 4.41e-02 | 5.60e-03 |
| Muscle contraction | 116 | 6.33e-20 | 4.32e-18 | 0.5520 | 0.056400 | -0.499000 | -0.159000 | -0.165000 | 2.95e-01 | 1.94e-20 | 3.13e-03 | 2.17e-03 |
| Defects in cobalamin (B12) metabolism | 10 | 1.15e-01 | 1.76e-01 | 0.5510 | -0.243000 | 0.139000 | -0.436000 | -0.188000 | 1.83e-01 | 4.48e-01 | 1.69e-02 | 3.03e-01 |
| DNA strand elongation | 30 | 2.73e-04 | 1.10e-03 | 0.5510 | 0.015200 | 0.136000 | 0.355000 | 0.399000 | 8.85e-01 | 1.97e-01 | 7.78e-04 | 1.54e-04 |
| SUMOylation of intracellular receptors | 23 | 4.59e-03 | 1.25e-02 | 0.5490 | -0.340000 | -0.247000 | -0.178000 | -0.305000 | 4.81e-03 | 4.04e-02 | 1.39e-01 | 1.15e-02 |
| Peroxisomal lipid metabolism | 22 | 5.99e-03 | 1.54e-02 | 0.5480 | -0.316000 | -0.094900 | -0.405000 | -0.166000 | 1.03e-02 | 4.41e-01 | 1.01e-03 | 1.78e-01 |
| Ion homeostasis | 36 | 3.52e-05 | 1.77e-04 | 0.5470 | -0.016300 | -0.432000 | -0.282000 | -0.181000 | 8.65e-01 | 7.25e-06 | 3.40e-03 | 6.07e-02 |
| Gap junction trafficking | 10 | 1.98e-01 | 2.74e-01 | 0.5460 | 0.415000 | 0.070200 | 0.174000 | 0.301000 | 2.30e-02 | 7.01e-01 | 3.42e-01 | 9.95e-02 |
| Cyclin A/B1/B2 associated events during G2/M transition | 17 | 1.13e-02 | 2.63e-02 | 0.5430 | -0.011600 | 0.395000 | 0.361000 | 0.091200 | 9.34e-01 | 4.78e-03 | 9.98e-03 | 5.15e-01 |
| Synthesis of PIPs at the late endosome membrane | 10 | 6.24e-03 | 1.59e-02 | 0.5430 | -0.367000 | 0.258000 | -0.116000 | 0.282000 | 4.43e-02 | 1.57e-01 | 5.27e-01 | 1.22e-01 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 24 | 3.45e-04 | 1.35e-03 | 0.5420 | 0.003880 | 0.068100 | 0.510000 | 0.172000 | 9.74e-01 | 5.64e-01 | 1.56e-05 | 1.46e-01 |
| mRNA 3'-end processing | 48 | 6.85e-09 | 8.09e-08 | 0.5420 | -0.120000 | 0.423000 | 0.304000 | -0.086900 | 1.50e-01 | 4.10e-07 | 2.68e-04 | 2.98e-01 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 134 | 5.95e-26 | 8.13e-24 | 0.5380 | -0.100000 | 0.359000 | 0.386000 | -0.041700 | 4.60e-02 | 8.19e-13 | 1.39e-14 | 4.06e-01 |
| Semaphorin interactions | 53 | 1.12e-05 | 6.60e-05 | 0.5380 | 0.302000 | -0.173000 | 0.245000 | 0.329000 | 1.43e-04 | 2.96e-02 | 2.05e-03 | 3.57e-05 |
| Nuclear Pore Complex (NPC) Disassembly | 27 | 1.55e-04 | 6.67e-04 | 0.5380 | -0.223000 | 0.428000 | 0.207000 | 0.117000 | 4.52e-02 | 1.21e-04 | 6.28e-02 | 2.91e-01 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 67 | 1.20e-06 | 9.14e-06 | 0.5370 | 0.304000 | -0.064900 | 0.256000 | 0.356000 | 1.78e-05 | 3.59e-01 | 3.02e-04 | 4.80e-07 |
| Response to elevated platelet cytosolic Ca2+ | 89 | 2.55e-10 | 3.82e-09 | 0.5370 | 0.376000 | -0.138000 | 0.139000 | 0.330000 | 9.57e-10 | 2.45e-02 | 2.35e-02 | 7.95e-08 |
| ATF6 (ATF6-alpha) activates chaperone genes | 10 | 7.48e-02 | 1.26e-01 | 0.5360 | 0.010100 | 0.117000 | 0.504000 | 0.139000 | 9.56e-01 | 5.21e-01 | 5.80e-03 | 4.46e-01 |
| rRNA processing in the nucleus and cytosol | 143 | 1.65e-27 | 2.90e-25 | 0.5360 | -0.102000 | 0.368000 | 0.372000 | -0.053300 | 3.61e-02 | 3.72e-14 | 1.71e-14 | 2.73e-01 |
| mRNA Splicing - Minor Pathway | 47 | 1.55e-08 | 1.66e-07 | 0.5350 | -0.201000 | 0.399000 | 0.275000 | -0.106000 | 1.74e-02 | 2.26e-06 | 1.11e-03 | 2.10e-01 |
| RNA Polymerase II Transcription Termination | 56 | 5.85e-10 | 7.91e-09 | 0.5320 | -0.123000 | 0.413000 | 0.303000 | -0.074400 | 1.12e-01 | 9.23e-08 | 8.74e-05 | 3.36e-01 |
| Lagging Strand Synthesis | 20 | 5.06e-03 | 1.35e-02 | 0.5310 | -0.044900 | 0.222000 | 0.295000 | 0.380000 | 7.28e-01 | 8.65e-02 | 2.26e-02 | 3.25e-03 |
| SUMOylation of RNA binding proteins | 38 | 8.16e-06 | 4.99e-05 | 0.5300 | -0.112000 | 0.452000 | 0.247000 | 0.052400 | 2.32e-01 | 1.40e-06 | 8.35e-03 | 5.77e-01 |
| Protein localization | 136 | 1.53e-13 | 4.26e-12 | 0.5290 | -0.360000 | -0.045500 | -0.245000 | -0.297000 | 4.58e-13 | 3.62e-01 | 8.54e-07 | 2.43e-09 |
| Pausing and recovery of Tat-mediated HIV elongation | 25 | 5.80e-04 | 2.11e-03 | 0.5290 | -0.042100 | 0.300000 | 0.424000 | 0.088900 | 7.16e-01 | 9.34e-03 | 2.41e-04 | 4.42e-01 |
| Tat-mediated HIV elongation arrest and recovery | 25 | 5.80e-04 | 2.11e-03 | 0.5290 | -0.042100 | 0.300000 | 0.424000 | 0.088900 | 7.16e-01 | 9.34e-03 | 2.41e-04 | 4.42e-01 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | 12 | 3.69e-02 | 7.13e-02 | 0.5270 | 0.179000 | -0.467000 | -0.079700 | -0.147000 | 2.83e-01 | 5.13e-03 | 6.33e-01 | 3.78e-01 |
| Response of Mtb to phagocytosis | 18 | 6.62e-03 | 1.68e-02 | 0.5270 | 0.054800 | 0.273000 | 0.443000 | 0.062800 | 6.88e-01 | 4.47e-02 | 1.15e-03 | 6.45e-01 |
| FOXO-mediated transcription of cell death genes | 14 | 4.44e-02 | 8.25e-02 | 0.5260 | -0.395000 | -0.128000 | -0.068100 | -0.315000 | 1.05e-02 | 4.07e-01 | 6.59e-01 | 4.14e-02 |
| Signaling by FGFR2 IIIa TM | 16 | 7.98e-03 | 1.97e-02 | 0.5260 | -0.117000 | 0.306000 | 0.410000 | 0.034500 | 4.17e-01 | 3.43e-02 | 4.55e-03 | 8.11e-01 |
| Attenuation phase | 20 | 7.79e-04 | 2.74e-03 | 0.5250 | -0.092300 | 0.329000 | 0.390000 | -0.075600 | 4.75e-01 | 1.08e-02 | 2.52e-03 | 5.58e-01 |
| CLEC7A (Dectin-1) induces NFAT activation | 10 | 1.81e-01 | 2.54e-01 | 0.5240 | -0.011600 | -0.329000 | -0.299000 | -0.277000 | 9.50e-01 | 7.14e-02 | 1.01e-01 | 1.30e-01 |
| Other semaphorin interactions | 14 | 1.16e-02 | 2.66e-02 | 0.5240 | 0.301000 | -0.182000 | -0.123000 | 0.368000 | 5.16e-02 | 2.38e-01 | 4.26e-01 | 1.72e-02 |
| Unblocking of NMDA receptors, glutamate binding and activation | 10 | 9.52e-02 | 1.51e-01 | 0.5220 | 0.024500 | -0.440000 | -0.124000 | -0.253000 | 8.93e-01 | 1.61e-02 | 4.99e-01 | 1.67e-01 |
| Metal ion SLC transporters | 17 | 9.88e-02 | 1.56e-01 | 0.5220 | 0.263000 | 0.096300 | 0.271000 | 0.348000 | 6.10e-02 | 4.92e-01 | 5.28e-02 | 1.31e-02 |
| Insulin receptor recycling | 17 | 9.48e-03 | 2.26e-02 | 0.5220 | 0.085800 | 0.018500 | 0.161000 | 0.488000 | 5.40e-01 | 8.95e-01 | 2.52e-01 | 4.91e-04 |
| Adherens junctions interactions | 11 | 9.29e-02 | 1.48e-01 | 0.5210 | 0.235000 | -0.213000 | 0.050100 | 0.410000 | 1.77e-01 | 2.21e-01 | 7.74e-01 | 1.84e-02 |
| Activation of the pre-replicative complex | 27 | 2.09e-04 | 8.61e-04 | 0.5210 | -0.135000 | 0.274000 | 0.262000 | 0.332000 | 2.26e-01 | 1.38e-02 | 1.87e-02 | 2.86e-03 |
| Infection with Mycobacterium tuberculosis | 19 | 8.34e-03 | 2.05e-02 | 0.5210 | 0.091300 | 0.255000 | 0.436000 | 0.092200 | 4.91e-01 | 5.46e-02 | 1.02e-03 | 4.87e-01 |
| Glycosphingolipid metabolism | 32 | 4.96e-04 | 1.86e-03 | 0.5210 | 0.288000 | -0.107000 | 0.094000 | 0.410000 | 4.79e-03 | 2.93e-01 | 3.58e-01 | 6.07e-05 |
| MET activates RAP1 and RAC1 | 10 | 2.18e-02 | 4.49e-02 | 0.5210 | -0.126000 | 0.046200 | 0.503000 | 0.008130 | 4.91e-01 | 8.00e-01 | 5.86e-03 | 9.65e-01 |
| Integrin signaling | 20 | 1.44e-02 | 3.14e-02 | 0.5200 | 0.265000 | -0.074400 | 0.405000 | 0.173000 | 4.06e-02 | 5.65e-01 | 1.70e-03 | 1.80e-01 |
| Cell-extracellular matrix interactions | 16 | 5.57e-02 | 9.94e-02 | 0.5190 | 0.313000 | -0.258000 | 0.238000 | 0.220000 | 3.03e-02 | 7.40e-02 | 9.88e-02 | 1.27e-01 |
| Bile acid and bile salt metabolism | 20 | 6.01e-02 | 1.05e-01 | 0.5190 | -0.271000 | -0.116000 | -0.317000 | -0.287000 | 3.61e-02 | 3.71e-01 | 1.42e-02 | 2.62e-02 |
| Potassium Channels | 32 | 2.25e-05 | 1.19e-04 | 0.5190 | 0.271000 | -0.344000 | -0.253000 | -0.112000 | 7.91e-03 | 7.52e-04 | 1.34e-02 | 2.72e-01 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 10 | 8.30e-02 | 1.36e-01 | 0.5180 | -0.220000 | 0.338000 | 0.322000 | 0.051300 | 2.29e-01 | 6.41e-02 | 7.83e-02 | 7.79e-01 |
| G beta:gamma signalling through BTK | 10 | 5.93e-02 | 1.05e-01 | 0.5170 | 0.468000 | -0.051900 | -0.108000 | 0.183000 | 1.03e-02 | 7.76e-01 | 5.56e-01 | 3.16e-01 |
| Sema4D induced cell migration and growth-cone collapse | 19 | 1.43e-02 | 3.13e-02 | 0.5140 | 0.352000 | -0.206000 | 0.286000 | 0.128000 | 7.90e-03 | 1.20e-01 | 3.10e-02 | 3.32e-01 |
| Gap junction trafficking and regulation | 12 | 1.35e-01 | 1.97e-01 | 0.5140 | 0.427000 | 0.013100 | 0.119000 | 0.259000 | 1.05e-02 | 9.37e-01 | 4.77e-01 | 1.20e-01 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 21 | 4.03e-03 | 1.12e-02 | 0.5130 | -0.064900 | 0.286000 | 0.406000 | 0.112000 | 6.07e-01 | 2.34e-02 | 1.27e-03 | 3.73e-01 |
| STING mediated induction of host immune responses | 11 | 4.52e-02 | 8.40e-02 | 0.5130 | 0.256000 | 0.149000 | -0.020200 | 0.418000 | 1.42e-01 | 3.92e-01 | 9.08e-01 | 1.63e-02 |
| Response of EIF2AK1 (HRI) to heme deficiency | 14 | 9.03e-04 | 3.11e-03 | 0.5110 | -0.200000 | 0.068500 | 0.366000 | -0.286000 | 1.95e-01 | 6.57e-01 | 1.78e-02 | 6.36e-02 |
| Constitutive Signaling by Overexpressed ERBB2 | 10 | 2.31e-01 | 3.11e-01 | 0.5100 | 0.055300 | 0.093300 | 0.345000 | 0.359000 | 7.62e-01 | 6.09e-01 | 5.87e-02 | 4.92e-02 |
| Transcriptional regulation by small RNAs | 39 | 1.02e-05 | 6.06e-05 | 0.5100 | -0.169000 | 0.406000 | 0.214000 | 0.144000 | 6.85e-02 | 1.15e-05 | 2.10e-02 | 1.20e-01 |
| Regulated proteolysis of p75NTR | 11 | 2.21e-01 | 3.01e-01 | 0.5070 | 0.374000 | 0.058700 | 0.148000 | 0.304000 | 3.17e-02 | 7.36e-01 | 3.95e-01 | 8.14e-02 |
| FGFR2 alternative splicing | 22 | 4.83e-03 | 1.30e-02 | 0.5060 | -0.095000 | 0.392000 | 0.291000 | 0.092300 | 4.41e-01 | 1.48e-03 | 1.83e-02 | 4.54e-01 |
| Sema4D in semaphorin signaling | 23 | 4.68e-03 | 1.27e-02 | 0.5050 | 0.264000 | -0.246000 | 0.322000 | 0.146000 | 2.86e-02 | 4.15e-02 | 7.55e-03 | 2.25e-01 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | 19 | 6.93e-03 | 1.74e-02 | 0.5040 | -0.389000 | 0.171000 | 0.081400 | -0.258000 | 3.33e-03 | 1.96e-01 | 5.39e-01 | 5.19e-02 |
| Platelet Aggregation (Plug Formation) | 21 | 2.43e-02 | 4.90e-02 | 0.5040 | 0.275000 | -0.087300 | 0.363000 | 0.196000 | 2.90e-02 | 4.89e-01 | 3.97e-03 | 1.21e-01 |
| NCAM signaling for neurite out-growth | 38 | 1.78e-05 | 9.67e-05 | 0.5030 | 0.323000 | -0.350000 | -0.112000 | 0.118000 | 5.77e-04 | 1.92e-04 | 2.32e-01 | 2.08e-01 |
| Activation of G protein gated Potassium channels | 13 | 1.88e-02 | 3.95e-02 | 0.5020 | 0.360000 | -0.207000 | -0.242000 | 0.145000 | 2.49e-02 | 1.96e-01 | 1.31e-01 | 3.65e-01 |
| G protein gated Potassium channels | 13 | 1.88e-02 | 3.95e-02 | 0.5020 | 0.360000 | -0.207000 | -0.242000 | 0.145000 | 2.49e-02 | 1.96e-01 | 1.31e-01 | 3.65e-01 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 13 | 1.88e-02 | 3.95e-02 | 0.5020 | 0.360000 | -0.207000 | -0.242000 | 0.145000 | 2.49e-02 | 1.96e-01 | 1.31e-01 | 3.65e-01 |
| tRNA processing in the nucleus | 48 | 1.12e-06 | 8.69e-06 | 0.5000 | -0.118000 | 0.445000 | 0.195000 | 0.006760 | 1.56e-01 | 9.66e-08 | 1.93e-02 | 9.35e-01 |
| Triglyceride catabolism | 13 | 1.19e-01 | 1.81e-01 | 0.5000 | -0.005710 | -0.274000 | -0.347000 | -0.233000 | 9.72e-01 | 8.69e-02 | 3.01e-02 | 1.47e-01 |
| Formation of RNA Pol II elongation complex | 50 | 1.77e-07 | 1.70e-06 | 0.5000 | -0.194000 | 0.371000 | 0.273000 | -0.002330 | 1.80e-02 | 5.62e-06 | 8.55e-04 | 9.77e-01 |
| RNA Polymerase II Transcription Elongation | 50 | 1.77e-07 | 1.70e-06 | 0.5000 | -0.194000 | 0.371000 | 0.273000 | -0.002330 | 1.80e-02 | 5.62e-06 | 8.55e-04 | 9.77e-01 |
| Interleukin-20 family signaling | 12 | 1.14e-01 | 1.75e-01 | 0.4990 | 0.328000 | -0.315000 | 0.003210 | 0.205000 | 4.89e-02 | 5.92e-02 | 9.85e-01 | 2.19e-01 |
| HIV elongation arrest and recovery | 27 | 6.14e-04 | 2.19e-03 | 0.4980 | -0.074600 | 0.335000 | 0.360000 | 0.033600 | 5.03e-01 | 2.60e-03 | 1.22e-03 | 7.62e-01 |
| Pausing and recovery of HIV elongation | 27 | 6.14e-04 | 2.19e-03 | 0.4980 | -0.074600 | 0.335000 | 0.360000 | 0.033600 | 5.03e-01 | 2.60e-03 | 1.22e-03 | 7.62e-01 |
| Metabolism of cofactors | 16 | 9.32e-02 | 1.48e-01 | 0.4970 | -0.350000 | -0.151000 | -0.236000 | -0.213000 | 1.53e-02 | 2.95e-01 | 1.02e-01 | 1.40e-01 |
| RNA polymerase II transcribes snRNA genes | 67 | 5.53e-10 | 7.72e-09 | 0.4960 | -0.215000 | 0.387000 | 0.198000 | -0.107000 | 2.38e-03 | 4.56e-08 | 5.11e-03 | 1.30e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 16 | 1.77e-02 | 3.78e-02 | 0.4960 | 0.176000 | 0.238000 | 0.055800 | 0.394000 | 2.23e-01 | 9.88e-02 | 6.99e-01 | 6.38e-03 |
| Amyloid fiber formation | 29 | 8.50e-03 | 2.09e-02 | 0.4960 | 0.253000 | -0.184000 | 0.246000 | 0.295000 | 1.83e-02 | 8.60e-02 | 2.22e-02 | 5.92e-03 |
| MET promotes cell motility | 24 | 6.84e-03 | 1.73e-02 | 0.4950 | 0.320000 | -0.247000 | 0.247000 | 0.143000 | 6.67e-03 | 3.61e-02 | 3.60e-02 | 2.24e-01 |
| Negative regulation of MET activity | 16 | 8.37e-02 | 1.36e-01 | 0.4950 | 0.045600 | 0.182000 | 0.353000 | 0.291000 | 7.52e-01 | 2.07e-01 | 1.45e-02 | 4.42e-02 |
| rRNA processing | 154 | 1.49e-25 | 1.83e-23 | 0.4920 | -0.137000 | 0.339000 | 0.320000 | -0.080100 | 3.38e-03 | 4.47e-13 | 8.76e-12 | 8.74e-02 |
| Synthesis of PIPs at the Golgi membrane | 15 | 4.75e-02 | 8.76e-02 | 0.4920 | 0.027400 | 0.327000 | 0.171000 | 0.324000 | 8.54e-01 | 2.85e-02 | 2.52e-01 | 2.98e-02 |
| Nephrin family interactions | 17 | 1.21e-01 | 1.83e-01 | 0.4900 | 0.171000 | 0.137000 | 0.279000 | 0.339000 | 2.22e-01 | 3.29e-01 | 4.67e-02 | 1.57e-02 |
| DNA Damage/Telomere Stress Induced Senescence | 26 | 1.14e-02 | 2.64e-02 | 0.4900 | 0.121000 | 0.225000 | 0.234000 | 0.345000 | 2.84e-01 | 4.69e-02 | 3.87e-02 | 2.32e-03 |
| TRAF3-dependent IRF activation pathway | 12 | 5.38e-02 | 9.64e-02 | 0.4860 | 0.150000 | -0.114000 | 0.025100 | 0.448000 | 3.69e-01 | 4.96e-01 | 8.81e-01 | 7.26e-03 |
| Polymerase switching on the C-strand of the telomere | 22 | 2.77e-02 | 5.51e-02 | 0.4860 | 0.094600 | 0.252000 | 0.248000 | 0.319000 | 4.43e-01 | 4.08e-02 | 4.42e-02 | 9.58e-03 |
| Signal transduction by L1 | 20 | 2.99e-02 | 5.88e-02 | 0.4850 | 0.412000 | -0.130000 | 0.119000 | 0.186000 | 1.42e-03 | 3.13e-01 | 3.58e-01 | 1.50e-01 |
| Late Phase of HIV Life Cycle | 112 | 1.97e-15 | 7.34e-14 | 0.4830 | -0.149000 | 0.359000 | 0.285000 | 0.031800 | 6.63e-03 | 5.38e-11 | 1.97e-07 | 5.62e-01 |
| mRNA Capping | 26 | 1.26e-03 | 4.12e-03 | 0.4830 | -0.216000 | 0.370000 | 0.218000 | -0.043300 | 5.69e-02 | 1.09e-03 | 5.40e-02 | 7.03e-01 |
| Pentose phosphate pathway | 12 | 1.90e-01 | 2.64e-01 | 0.4820 | 0.300000 | 0.167000 | 0.306000 | 0.142000 | 7.21e-02 | 3.16e-01 | 6.64e-02 | 3.94e-01 |
| PERK regulates gene expression | 28 | 5.81e-04 | 2.11e-03 | 0.4810 | -0.164000 | 0.356000 | 0.277000 | -0.032600 | 1.33e-01 | 1.12e-03 | 1.13e-02 | 7.66e-01 |
| GPCR ligand binding | 73 | 3.22e-09 | 3.99e-08 | 0.4790 | 0.432000 | -0.159000 | 0.034000 | 0.129000 | 1.86e-10 | 1.88e-02 | 6.17e-01 | 5.69e-02 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 12 | 7.16e-02 | 1.21e-01 | 0.4790 | -0.169000 | 0.220000 | 0.278000 | 0.274000 | 3.11e-01 | 1.87e-01 | 9.58e-02 | 1.00e-01 |
| Mitophagy | 24 | 2.01e-02 | 4.18e-02 | 0.4780 | -0.340000 | 0.135000 | -0.087900 | -0.295000 | 3.90e-03 | 2.54e-01 | 4.56e-01 | 1.23e-02 |
| Platelet activation, signaling and aggregation | 168 | 6.57e-15 | 2.31e-13 | 0.4770 | 0.353000 | -0.088900 | 0.150000 | 0.269000 | 3.56e-15 | 4.77e-02 | 8.56e-04 | 1.98e-09 |
| Diseases of glycosylation | 95 | 3.08e-09 | 3.86e-08 | 0.4760 | 0.377000 | -0.113000 | 0.099500 | 0.249000 | 2.35e-10 | 5.86e-02 | 9.46e-02 | 2.84e-05 |
| Metabolism of RNA | 566 | 1.13e-79 | 1.39e-76 | 0.4750 | -0.152000 | 0.371000 | 0.248000 | -0.064000 | 1.16e-09 | 1.78e-50 | 2.56e-23 | 1.03e-02 |
| HIV Life Cycle | 122 | 2.62e-16 | 1.11e-14 | 0.4750 | -0.156000 | 0.350000 | 0.279000 | 0.036000 | 2.93e-03 | 2.77e-11 | 1.14e-07 | 4.94e-01 |
| Telomere C-strand (Lagging Strand) Synthesis | 30 | 5.05e-03 | 1.35e-02 | 0.4730 | 0.061000 | 0.238000 | 0.242000 | 0.324000 | 5.64e-01 | 2.44e-02 | 2.17e-02 | 2.13e-03 |
| p75NTR recruits signalling complexes | 10 | 3.19e-01 | 4.03e-01 | 0.4730 | 0.202000 | 0.112000 | 0.377000 | 0.167000 | 2.68e-01 | 5.40e-01 | 3.89e-02 | 3.60e-01 |
| Peptide chain elongation | 53 | 1.89e-10 | 2.94e-09 | 0.4720 | -0.009730 | -0.068900 | 0.467000 | -0.000315 | 9.03e-01 | 3.86e-01 | 4.23e-09 | 9.97e-01 |
| Lysosome Vesicle Biogenesis | 26 | 3.62e-02 | 7.01e-02 | 0.4720 | 0.199000 | 0.093200 | 0.239000 | 0.342000 | 7.92e-02 | 4.11e-01 | 3.49e-02 | 2.53e-03 |
| RNA Pol II CTD phosphorylation and interaction with CE | 24 | 3.43e-03 | 9.77e-03 | 0.4720 | -0.188000 | 0.377000 | 0.201000 | -0.067800 | 1.10e-01 | 1.40e-03 | 8.85e-02 | 5.65e-01 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 24 | 3.43e-03 | 9.77e-03 | 0.4720 | -0.188000 | 0.377000 | 0.201000 | -0.067800 | 1.10e-01 | 1.40e-03 | 8.85e-02 | 5.65e-01 |
| Leishmania infection | 118 | 9.74e-10 | 1.30e-08 | 0.4710 | 0.335000 | -0.078700 | 0.170000 | 0.274000 | 3.62e-10 | 1.41e-01 | 1.48e-03 | 3.00e-07 |
| Prostacyclin signalling through prostacyclin receptor | 12 | 7.82e-02 | 1.30e-01 | 0.4710 | 0.441000 | -0.089100 | -0.049100 | 0.131000 | 8.21e-03 | 5.93e-01 | 7.69e-01 | 4.34e-01 |
| NF-kB is activated and signals survival | 10 | 1.97e-01 | 2.73e-01 | 0.4700 | 0.202000 | -0.141000 | 0.380000 | 0.127000 | 2.70e-01 | 4.40e-01 | 3.76e-02 | 4.88e-01 |
| Basigin interactions | 17 | 6.46e-02 | 1.11e-01 | 0.4700 | 0.217000 | -0.317000 | 0.123000 | 0.241000 | 1.21e-01 | 2.38e-02 | 3.80e-01 | 8.55e-02 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 63 | 1.73e-13 | 4.72e-12 | 0.4700 | -0.069800 | -0.031400 | 0.461000 | -0.050800 | 3.39e-01 | 6.67e-01 | 2.62e-10 | 4.86e-01 |
| Regulation of HSF1-mediated heat shock response | 65 | 2.09e-08 | 2.18e-07 | 0.4700 | -0.174000 | 0.362000 | 0.244000 | 0.006350 | 1.55e-02 | 4.77e-07 | 6.83e-04 | 9.30e-01 |
| Processive synthesis on the lagging strand | 15 | 7.02e-02 | 1.19e-01 | 0.4650 | -0.038500 | 0.121000 | 0.283000 | 0.347000 | 7.96e-01 | 4.17e-01 | 5.80e-02 | 2.00e-02 |
| Selenocysteine synthesis | 56 | 1.18e-11 | 2.27e-10 | 0.4640 | -0.041600 | -0.030400 | 0.458000 | -0.057100 | 5.90e-01 | 6.95e-01 | 3.19e-09 | 4.61e-01 |
| SRP-dependent cotranslational protein targeting to membrane | 74 | 4.94e-12 | 1.03e-10 | 0.4620 | -0.017900 | 0.096700 | 0.452000 | 0.018100 | 7.90e-01 | 1.51e-01 | 1.94e-11 | 7.88e-01 |
| Signal amplification | 20 | 6.32e-02 | 1.09e-01 | 0.4620 | 0.354000 | 0.059000 | 0.127000 | 0.261000 | 6.15e-03 | 6.48e-01 | 3.24e-01 | 4.34e-02 |
| Interleukin-37 signaling | 16 | 1.73e-01 | 2.45e-01 | 0.4600 | 0.158000 | 0.027500 | 0.353000 | 0.247000 | 2.75e-01 | 8.49e-01 | 1.46e-02 | 8.68e-02 |
| Transcriptional regulation of granulopoiesis | 23 | 6.67e-02 | 1.14e-01 | 0.4590 | 0.266000 | -0.007070 | 0.307000 | 0.214000 | 2.74e-02 | 9.53e-01 | 1.08e-02 | 7.57e-02 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 20 | 1.07e-02 | 2.51e-02 | 0.4590 | 0.042400 | -0.279000 | 0.298000 | 0.205000 | 7.43e-01 | 3.08e-02 | 2.13e-02 | 1.13e-01 |
| Activation of ATR in response to replication stress | 28 | 2.55e-03 | 7.50e-03 | 0.4580 | -0.125000 | 0.306000 | 0.238000 | 0.210000 | 2.52e-01 | 5.15e-03 | 2.92e-02 | 5.44e-02 |
| Processing of Capped Intronless Pre-mRNA | 25 | 1.61e-03 | 5.04e-03 | 0.4570 | -0.198000 | 0.264000 | 0.316000 | -0.007290 | 8.71e-02 | 2.23e-02 | 6.35e-03 | 9.50e-01 |
| Interleukin-6 signaling | 10 | 3.77e-01 | 4.60e-01 | 0.4560 | 0.304000 | -0.202000 | 0.159000 | 0.223000 | 9.62e-02 | 2.69e-01 | 3.85e-01 | 2.22e-01 |
| Neutrophil degranulation | 290 | 6.15e-22 | 4.45e-20 | 0.4550 | 0.227000 | -0.060600 | 0.207000 | 0.330000 | 3.96e-11 | 7.81e-02 | 1.61e-09 | 6.47e-22 |
| E2F mediated regulation of DNA replication | 19 | 6.94e-03 | 1.74e-02 | 0.4550 | -0.274000 | 0.241000 | 0.190000 | 0.194000 | 3.88e-02 | 6.91e-02 | 1.52e-01 | 1.43e-01 |
| Processing of Intronless Pre-mRNAs | 17 | 1.41e-02 | 3.10e-02 | 0.4540 | -0.225000 | 0.223000 | 0.325000 | -0.011300 | 1.08e-01 | 1.11e-01 | 2.06e-02 | 9.36e-01 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 24 | 7.02e-02 | 1.19e-01 | 0.4530 | -0.290000 | -0.063900 | -0.261000 | -0.221000 | 1.39e-02 | 5.88e-01 | 2.69e-02 | 6.08e-02 |
| Viral mRNA Translation | 53 | 4.52e-10 | 6.46e-09 | 0.4520 | -0.017000 | -0.055300 | 0.448000 | -0.030100 | 8.30e-01 | 4.87e-01 | 1.76e-08 | 7.05e-01 |
| HATs acetylate histones | 71 | 6.55e-09 | 7.86e-08 | 0.4520 | -0.336000 | 0.235000 | 0.123000 | -0.145000 | 1.02e-06 | 6.46e-04 | 7.28e-02 | 3.51e-02 |
| Eukaryotic Translation Elongation | 56 | 8.23e-11 | 1.39e-09 | 0.4520 | -0.035200 | -0.088600 | 0.441000 | -0.024600 | 6.49e-01 | 2.52e-01 | 1.19e-08 | 7.50e-01 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | 11 | 5.05e-02 | 9.17e-02 | 0.4510 | -0.058600 | -0.299000 | -0.008970 | 0.333000 | 7.36e-01 | 8.56e-02 | 9.59e-01 | 5.62e-02 |
| Inwardly rectifying K+ channels | 16 | 2.26e-02 | 4.64e-02 | 0.4510 | 0.269000 | -0.218000 | -0.284000 | -0.052900 | 6.25e-02 | 1.32e-01 | 4.93e-02 | 7.14e-01 |
| Synthesis of PIPs at the early endosome membrane | 16 | 3.29e-02 | 6.44e-02 | 0.4510 | -0.084000 | 0.153000 | 0.199000 | 0.365000 | 5.61e-01 | 2.90e-01 | 1.68e-01 | 1.16e-02 |
| Synthesis of IP3 and IP4 in the cytosol | 19 | 2.39e-02 | 4.84e-02 | 0.4500 | 0.168000 | -0.415000 | -0.028600 | -0.030300 | 2.05e-01 | 1.73e-03 | 8.29e-01 | 8.19e-01 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | 36 | 1.93e-04 | 8.05e-04 | 0.4500 | -0.141000 | 0.307000 | 0.296000 | 0.010600 | 1.43e-01 | 1.43e-03 | 2.14e-03 | 9.13e-01 |
| HIV Transcription Elongation | 36 | 1.93e-04 | 8.05e-04 | 0.4500 | -0.141000 | 0.307000 | 0.296000 | 0.010600 | 1.43e-01 | 1.43e-03 | 2.14e-03 | 9.13e-01 |
| Tat-mediated elongation of the HIV-1 transcript | 36 | 1.93e-04 | 8.05e-04 | 0.4500 | -0.141000 | 0.307000 | 0.296000 | 0.010600 | 1.43e-01 | 1.43e-03 | 2.14e-03 | 9.13e-01 |
| Formation of HIV elongation complex in the absence of HIV Tat | 38 | 1.16e-04 | 5.22e-04 | 0.4490 | -0.159000 | 0.332000 | 0.257000 | -0.024600 | 8.97e-02 | 4.08e-04 | 6.21e-03 | 7.93e-01 |
| Calnexin/calreticulin cycle | 23 | 8.29e-02 | 1.36e-01 | 0.4490 | 0.137000 | 0.124000 | 0.291000 | 0.287000 | 2.56e-01 | 3.03e-01 | 1.56e-02 | 1.73e-02 |
| Receptor Mediated Mitophagy | 11 | 2.63e-01 | 3.45e-01 | 0.4490 | -0.203000 | 0.205000 | -0.096900 | -0.330000 | 2.45e-01 | 2.39e-01 | 5.78e-01 | 5.81e-02 |
| PKA activation | 15 | 6.81e-02 | 1.16e-01 | 0.4480 | 0.031000 | -0.438000 | -0.090000 | 0.017300 | 8.35e-01 | 3.34e-03 | 5.46e-01 | 9.08e-01 |
| Glycogen synthesis | 12 | 7.58e-02 | 1.27e-01 | 0.4480 | -0.392000 | -0.144000 | 0.041000 | -0.156000 | 1.88e-02 | 3.87e-01 | 8.06e-01 | 3.48e-01 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 16 | 1.49e-01 | 2.15e-01 | 0.4470 | 0.214000 | -0.013600 | 0.140000 | 0.367000 | 1.38e-01 | 9.25e-01 | 3.31e-01 | 1.12e-02 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 16 | 1.49e-01 | 2.15e-01 | 0.4470 | 0.214000 | -0.013600 | 0.140000 | 0.367000 | 1.38e-01 | 9.25e-01 | 3.31e-01 | 1.12e-02 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 57 | 1.06e-10 | 1.69e-09 | 0.4470 | -0.067400 | -0.018900 | 0.440000 | -0.036100 | 3.79e-01 | 8.06e-01 | 9.57e-09 | 6.38e-01 |
| Influenza Infection | 107 | 3.60e-14 | 1.11e-12 | 0.4460 | -0.050500 | 0.169000 | 0.406000 | 0.055000 | 3.69e-01 | 2.54e-03 | 4.37e-13 | 3.27e-01 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 11 | 2.20e-01 | 2.99e-01 | 0.4460 | 0.369000 | 0.059500 | 0.226000 | 0.088800 | 3.40e-02 | 7.33e-01 | 1.95e-01 | 6.10e-01 |
| AMER1 mutants destabilize the destruction complex | 13 | 6.02e-02 | 1.05e-01 | 0.4460 | -0.344000 | 0.190000 | 0.194000 | -0.079700 | 3.16e-02 | 2.36e-01 | 2.27e-01 | 6.19e-01 |
| APC truncation mutants have impaired AXIN binding | 13 | 6.02e-02 | 1.05e-01 | 0.4460 | -0.344000 | 0.190000 | 0.194000 | -0.079700 | 3.16e-02 | 2.36e-01 | 2.27e-01 | 6.19e-01 |
| AXIN missense mutants destabilize the destruction complex | 13 | 6.02e-02 | 1.05e-01 | 0.4460 | -0.344000 | 0.190000 | 0.194000 | -0.079700 | 3.16e-02 | 2.36e-01 | 2.27e-01 | 6.19e-01 |
| AXIN mutants destabilize the destruction complex, activating WNT signaling | 13 | 6.02e-02 | 1.05e-01 | 0.4460 | -0.344000 | 0.190000 | 0.194000 | -0.079700 | 3.16e-02 | 2.36e-01 | 2.27e-01 | 6.19e-01 |
| Truncations of AMER1 destabilize the destruction complex | 13 | 6.02e-02 | 1.05e-01 | 0.4460 | -0.344000 | 0.190000 | 0.194000 | -0.079700 | 3.16e-02 | 2.36e-01 | 2.27e-01 | 6.19e-01 |
| truncated APC mutants destabilize the destruction complex | 13 | 6.02e-02 | 1.05e-01 | 0.4460 | -0.344000 | 0.190000 | 0.194000 | -0.079700 | 3.16e-02 | 2.36e-01 | 2.27e-01 | 6.19e-01 |
| Methylation | 10 | 2.68e-01 | 3.48e-01 | 0.4450 | -0.376000 | -0.047900 | -0.215000 | -0.091100 | 3.97e-02 | 7.93e-01 | 2.38e-01 | 6.18e-01 |
| Regulation of RUNX1 Expression and Activity | 17 | 2.16e-02 | 4.46e-02 | 0.4450 | 0.343000 | 0.063900 | -0.074200 | 0.266000 | 1.44e-02 | 6.48e-01 | 5.96e-01 | 5.81e-02 |
| Regulation of MECP2 expression and activity | 26 | 5.69e-02 | 1.01e-01 | 0.4440 | -0.207000 | -0.077800 | -0.320000 | -0.214000 | 6.73e-02 | 4.93e-01 | 4.75e-03 | 5.92e-02 |
| G beta:gamma signalling through PLC beta | 12 | 9.95e-02 | 1.57e-01 | 0.4440 | 0.374000 | -0.119000 | -0.117000 | 0.171000 | 2.49e-02 | 4.76e-01 | 4.83e-01 | 3.06e-01 |
| Presynaptic function of Kainate receptors | 12 | 9.95e-02 | 1.57e-01 | 0.4440 | 0.374000 | -0.119000 | -0.117000 | 0.171000 | 2.49e-02 | 4.76e-01 | 4.83e-01 | 3.06e-01 |
| O-linked glycosylation | 50 | 9.63e-05 | 4.45e-04 | 0.4430 | 0.223000 | -0.183000 | 0.067200 | 0.329000 | 6.45e-03 | 2.53e-02 | 4.12e-01 | 5.71e-05 |
| Listeria monocytogenes entry into host cells | 15 | 2.14e-01 | 2.93e-01 | 0.4430 | 0.143000 | 0.162000 | 0.338000 | 0.186000 | 3.38e-01 | 2.77e-01 | 2.33e-02 | 2.11e-01 |
| Platelet calcium homeostasis | 17 | 4.83e-02 | 8.87e-02 | 0.4420 | 0.186000 | -0.366000 | -0.146000 | -0.076200 | 1.85e-01 | 8.99e-03 | 2.97e-01 | 5.87e-01 |
| Ribosomal scanning and start codon recognition | 45 | 2.81e-07 | 2.54e-06 | 0.4420 | -0.212000 | 0.125000 | 0.366000 | -0.026800 | 1.40e-02 | 1.47e-01 | 2.23e-05 | 7.56e-01 |
| RIPK1-mediated regulated necrosis | 22 | 9.22e-02 | 1.47e-01 | 0.4410 | 0.300000 | -0.130000 | 0.184000 | 0.231000 | 1.50e-02 | 2.91e-01 | 1.35e-01 | 6.04e-02 |
| Regulated Necrosis | 22 | 9.22e-02 | 1.47e-01 | 0.4410 | 0.300000 | -0.130000 | 0.184000 | 0.231000 | 1.50e-02 | 2.91e-01 | 1.35e-01 | 6.04e-02 |
| Regulation of necroptotic cell death | 22 | 9.22e-02 | 1.47e-01 | 0.4410 | 0.300000 | -0.130000 | 0.184000 | 0.231000 | 1.50e-02 | 2.91e-01 | 1.35e-01 | 6.04e-02 |
| Removal of the Flap Intermediate | 14 | 1.06e-01 | 1.65e-01 | 0.4410 | -0.075500 | 0.168000 | 0.259000 | 0.306000 | 6.25e-01 | 2.77e-01 | 9.39e-02 | 4.76e-02 |
| Eukaryotic Translation Termination | 55 | 2.98e-10 | 4.42e-09 | 0.4400 | -0.053800 | -0.048300 | 0.432000 | -0.042400 | 4.91e-01 | 5.36e-01 | 3.04e-08 | 5.87e-01 |
| Negative epigenetic regulation of rRNA expression | 43 | 1.28e-04 | 5.70e-04 | 0.4390 | -0.054800 | 0.389000 | 0.197000 | 0.000917 | 5.35e-01 | 1.03e-05 | 2.58e-02 | 9.92e-01 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 57 | 5.65e-06 | 3.60e-05 | 0.4390 | -0.117000 | 0.354000 | 0.206000 | 0.107000 | 1.26e-01 | 3.89e-06 | 7.16e-03 | 1.62e-01 |
| Amplification of signal from the kinetochores | 57 | 5.65e-06 | 3.60e-05 | 0.4390 | -0.117000 | 0.354000 | 0.206000 | 0.107000 | 1.26e-01 | 3.89e-06 | 7.16e-03 | 1.62e-01 |
| Translation | 222 | 1.58e-22 | 1.30e-20 | 0.4380 | -0.360000 | 0.145000 | 0.003910 | -0.204000 | 3.43e-20 | 2.23e-04 | 9.20e-01 | 1.77e-07 |
| Keratan sulfate biosynthesis | 17 | 1.07e-01 | 1.66e-01 | 0.4370 | 0.158000 | -0.197000 | 0.145000 | 0.325000 | 2.58e-01 | 1.59e-01 | 3.00e-01 | 2.03e-02 |
| Neurexins and neuroligins | 26 | 3.99e-03 | 1.11e-02 | 0.4370 | 0.241000 | -0.105000 | 0.345000 | 0.051000 | 3.34e-02 | 3.56e-01 | 2.32e-03 | 6.53e-01 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 11 | 3.91e-01 | 4.74e-01 | 0.4360 | 0.085800 | 0.152000 | 0.326000 | 0.231000 | 6.22e-01 | 3.84e-01 | 6.15e-02 | 1.85e-01 |
| Translesion Synthesis by POLH | 16 | 6.57e-02 | 1.12e-01 | 0.4340 | -0.219000 | 0.347000 | 0.136000 | 0.045200 | 1.30e-01 | 1.64e-02 | 3.45e-01 | 7.54e-01 |
| B-WICH complex positively regulates rRNA expression | 28 | 2.50e-03 | 7.39e-03 | 0.4340 | -0.124000 | 0.227000 | 0.342000 | 0.068500 | 2.55e-01 | 3.78e-02 | 1.75e-03 | 5.31e-01 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 15 | 9.61e-02 | 1.52e-01 | 0.4340 | -0.104000 | 0.369000 | 0.204000 | 0.005250 | 4.86e-01 | 1.35e-02 | 1.71e-01 | 9.72e-01 |
| Formation of the ternary complex, and subsequently, the 43S complex | 38 | 4.71e-06 | 3.13e-05 | 0.4340 | -0.179000 | 0.096900 | 0.383000 | -0.018700 | 5.69e-02 | 3.02e-01 | 4.44e-05 | 8.42e-01 |
| Sphingolipid metabolism | 63 | 4.94e-04 | 1.86e-03 | 0.4340 | 0.269000 | -0.025000 | 0.201000 | 0.274000 | 2.31e-04 | 7.32e-01 | 5.80e-03 | 1.76e-04 |
| Recycling pathway of L1 | 23 | 9.88e-02 | 1.56e-01 | 0.4340 | 0.250000 | -0.041700 | 0.169000 | 0.309000 | 3.83e-02 | 7.30e-01 | 1.60e-01 | 1.04e-02 |
| BBSome-mediated cargo-targeting to cilium | 18 | 3.97e-02 | 7.51e-02 | 0.4330 | -0.133000 | 0.401000 | 0.049900 | 0.078200 | 3.28e-01 | 3.20e-03 | 7.14e-01 | 5.66e-01 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 73 | 5.05e-12 | 1.03e-10 | 0.4330 | -0.143000 | 0.076000 | 0.400000 | -0.026900 | 3.46e-02 | 2.62e-01 | 3.46e-09 | 6.91e-01 |
| G beta:gamma signalling through CDC42 | 13 | 8.38e-02 | 1.36e-01 | 0.4330 | 0.340000 | -0.015900 | -0.091300 | 0.251000 | 3.39e-02 | 9.21e-01 | 5.69e-01 | 1.17e-01 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | 16 | 5.22e-02 | 9.40e-02 | 0.4330 | 0.338000 | -0.176000 | -0.114000 | 0.169000 | 1.91e-02 | 2.22e-01 | 4.28e-01 | 2.43e-01 |
| Influenza Viral RNA Transcription and Replication | 91 | 2.70e-12 | 6.25e-11 | 0.4320 | -0.096800 | 0.157000 | 0.390000 | 0.026300 | 1.11e-01 | 9.92e-03 | 1.42e-10 | 6.65e-01 |
| Fatty acid metabolism | 101 | 1.23e-07 | 1.20e-06 | 0.4320 | -0.143000 | -0.226000 | -0.296000 | -0.166000 | 1.35e-02 | 9.33e-05 | 3.01e-07 | 3.94e-03 |
| DARPP-32 events | 21 | 2.82e-02 | 5.58e-02 | 0.4310 | -0.130000 | -0.202000 | -0.090100 | -0.347000 | 3.04e-01 | 1.10e-01 | 4.75e-01 | 5.93e-03 |
| Formation of a pool of free 40S subunits | 63 | 2.19e-10 | 3.32e-09 | 0.4310 | -0.090000 | 0.016600 | 0.421000 | -0.007050 | 2.18e-01 | 8.20e-01 | 7.50e-09 | 9.23e-01 |
| Telomere Maintenance | 56 | 1.01e-04 | 4.62e-04 | 0.4310 | 0.021400 | 0.294000 | 0.236000 | 0.209000 | 7.82e-01 | 1.47e-04 | 2.33e-03 | 7.00e-03 |
| Resolution of Sister Chromatid Cohesion | 66 | 6.82e-07 | 5.67e-06 | 0.4310 | -0.153000 | 0.363000 | 0.157000 | 0.072200 | 3.14e-02 | 3.47e-07 | 2.73e-02 | 3.11e-01 |
| Glucagon-type ligand receptors | 11 | 1.35e-01 | 1.97e-01 | 0.4300 | 0.391000 | -0.096000 | -0.108000 | 0.107000 | 2.47e-02 | 5.82e-01 | 5.35e-01 | 5.39e-01 |
| Formation of Incision Complex in GG-NER | 39 | 2.13e-03 | 6.42e-03 | 0.4300 | -0.321000 | 0.174000 | -0.034100 | -0.224000 | 5.20e-04 | 6.08e-02 | 7.13e-01 | 1.58e-02 |
| ADP signalling through P2Y purinoceptor 1 | 15 | 1.20e-01 | 1.82e-01 | 0.4290 | 0.380000 | -0.036300 | 0.020400 | 0.195000 | 1.08e-02 | 8.08e-01 | 8.91e-01 | 1.92e-01 |
| PRC2 methylates histones and DNA | 14 | 1.60e-01 | 2.29e-01 | 0.4280 | -0.062600 | 0.259000 | 0.300000 | 0.149000 | 6.85e-01 | 9.38e-02 | 5.23e-02 | 3.34e-01 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 14 | 1.24e-01 | 1.87e-01 | 0.4280 | -0.131000 | 0.309000 | 0.203000 | 0.171000 | 3.96e-01 | 4.57e-02 | 1.88e-01 | 2.69e-01 |
| Nucleosome assembly | 14 | 1.24e-01 | 1.87e-01 | 0.4280 | -0.131000 | 0.309000 | 0.203000 | 0.171000 | 3.96e-01 | 4.57e-02 | 1.88e-01 | 2.69e-01 |
| Acyl chain remodelling of PE | 11 | 1.43e-01 | 2.08e-01 | 0.4270 | 0.342000 | 0.179000 | -0.027900 | 0.180000 | 4.95e-02 | 3.03e-01 | 8.73e-01 | 3.02e-01 |
| Extension of Telomeres | 43 | 1.70e-03 | 5.26e-03 | 0.4270 | 0.058300 | 0.282000 | 0.212000 | 0.233000 | 5.09e-01 | 1.41e-03 | 1.62e-02 | 8.28e-03 |
| Selenoamino acid metabolism | 68 | 1.83e-12 | 4.32e-11 | 0.4260 | -0.027700 | -0.013600 | 0.415000 | -0.089400 | 6.93e-01 | 8.47e-01 | 3.30e-09 | 2.03e-01 |
| Beta-catenin phosphorylation cascade | 15 | 6.05e-02 | 1.05e-01 | 0.4260 | -0.262000 | 0.248000 | 0.222000 | -0.042400 | 7.90e-02 | 9.59e-02 | 1.37e-01 | 7.76e-01 |
| E3 ubiquitin ligases ubiquitinate target proteins | 39 | 1.36e-04 | 6.00e-04 | 0.4260 | -0.317000 | 0.198000 | 0.145000 | -0.143000 | 6.17e-04 | 3.23e-02 | 1.18e-01 | 1.23e-01 |
| RAF-independent MAPK1/3 activation | 21 | 2.09e-02 | 4.35e-02 | 0.4250 | 0.318000 | -0.157000 | 0.233000 | 0.032500 | 1.17e-02 | 2.14e-01 | 6.46e-02 | 7.97e-01 |
| G0 and Early G1 | 23 | 4.01e-02 | 7.58e-02 | 0.4250 | -0.032400 | 0.285000 | 0.262000 | 0.172000 | 7.88e-01 | 1.80e-02 | 2.94e-02 | 1.54e-01 |
| Formation of TC-NER Pre-Incision Complex | 48 | 8.42e-05 | 3.96e-04 | 0.4250 | -0.258000 | 0.267000 | 0.064000 | -0.196000 | 2.02e-03 | 1.37e-03 | 4.44e-01 | 1.88e-02 |
| Cell-Cell communication | 71 | 5.57e-05 | 2.71e-04 | 0.4250 | 0.272000 | -0.169000 | 0.162000 | 0.226000 | 7.57e-05 | 1.38e-02 | 1.83e-02 | 9.91e-04 |
| Signaling by Leptin | 10 | 2.84e-01 | 3.66e-01 | 0.4240 | 0.065000 | -0.319000 | -0.157000 | -0.222000 | 7.22e-01 | 8.08e-02 | 3.91e-01 | 2.24e-01 |
| Activation of kainate receptors upon glutamate binding | 17 | 4.98e-02 | 9.06e-02 | 0.4240 | 0.368000 | -0.180000 | -0.072300 | 0.079100 | 8.63e-03 | 1.98e-01 | 6.06e-01 | 5.73e-01 |
| Translation initiation complex formation | 44 | 1.93e-06 | 1.40e-05 | 0.4220 | -0.195000 | 0.119000 | 0.355000 | -0.015000 | 2.56e-02 | 1.74e-01 | 4.61e-05 | 8.63e-01 |
| Sphingolipid de novo biosynthesis | 31 | 1.77e-02 | 3.78e-02 | 0.4220 | 0.247000 | 0.060400 | 0.311000 | 0.131000 | 1.75e-02 | 5.61e-01 | 2.76e-03 | 2.05e-01 |
| Activation of AMPK downstream of NMDARs | 10 | 4.29e-01 | 5.12e-01 | 0.4220 | -0.101000 | -0.281000 | -0.202000 | -0.220000 | 5.79e-01 | 1.24e-01 | 2.68e-01 | 2.30e-01 |
| HCMV Early Events | 50 | 6.15e-05 | 2.98e-04 | 0.4220 | -0.099000 | 0.363000 | 0.144000 | 0.125000 | 2.27e-01 | 9.02e-06 | 7.81e-02 | 1.26e-01 |
| Activation of BAD and translocation to mitochondria | 13 | 1.87e-01 | 2.61e-01 | 0.4210 | 0.074900 | -0.220000 | 0.200000 | 0.289000 | 6.40e-01 | 1.69e-01 | 2.12e-01 | 7.17e-02 |
| Anti-inflammatory response favouring Leishmania parasite infection | 56 | 3.75e-05 | 1.87e-04 | 0.4210 | 0.357000 | -0.156000 | 0.007930 | 0.157000 | 3.79e-06 | 4.41e-02 | 9.18e-01 | 4.18e-02 |
| Leishmania parasite growth and survival | 56 | 3.75e-05 | 1.87e-04 | 0.4210 | 0.357000 | -0.156000 | 0.007930 | 0.157000 | 3.79e-06 | 4.41e-02 | 9.18e-01 | 4.18e-02 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 71 | 4.16e-11 | 7.20e-10 | 0.4200 | -0.123000 | 0.059100 | 0.397000 | -0.023600 | 7.25e-02 | 3.90e-01 | 7.62e-09 | 7.32e-01 |
| Formation of the Early Elongation Complex | 30 | 3.10e-03 | 8.93e-03 | 0.4200 | -0.143000 | 0.299000 | 0.257000 | 0.000435 | 1.74e-01 | 4.59e-03 | 1.48e-02 | 9.97e-01 |
| Formation of the HIV-1 Early Elongation Complex | 30 | 3.10e-03 | 8.93e-03 | 0.4200 | -0.143000 | 0.299000 | 0.257000 | 0.000435 | 1.74e-01 | 4.59e-03 | 1.48e-02 | 9.97e-01 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 45 | 2.13e-06 | 1.52e-05 | 0.4190 | -0.205000 | 0.113000 | 0.347000 | 0.004750 | 1.75e-02 | 1.91e-01 | 5.72e-05 | 9.56e-01 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 25 | 2.88e-02 | 5.67e-02 | 0.4180 | 0.193000 | 0.294000 | 0.203000 | 0.101000 | 9.57e-02 | 1.09e-02 | 7.93e-02 | 3.82e-01 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 25 | 9.61e-03 | 2.28e-02 | 0.4180 | -0.276000 | 0.114000 | 0.062100 | -0.286000 | 1.71e-02 | 3.24e-01 | 5.91e-01 | 1.33e-02 |
| Diseases of programmed cell death | 24 | 8.37e-02 | 1.36e-01 | 0.4170 | 0.152000 | -0.051700 | 0.206000 | 0.326000 | 1.99e-01 | 6.62e-01 | 8.12e-02 | 5.72e-03 |
| RHO GTPases Activate ROCKs | 18 | 8.53e-02 | 1.38e-01 | 0.4170 | 0.257000 | -0.194000 | 0.248000 | 0.097000 | 5.96e-02 | 1.55e-01 | 6.87e-02 | 4.76e-01 |
| Gene Silencing by RNA | 54 | 1.13e-05 | 6.60e-05 | 0.4170 | -0.204000 | 0.353000 | 0.058900 | 0.063600 | 9.45e-03 | 7.44e-06 | 4.55e-01 | 4.20e-01 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 33 | 6.97e-04 | 2.46e-03 | 0.4170 | -0.222000 | 0.223000 | 0.271000 | 0.038600 | 2.76e-02 | 2.68e-02 | 7.14e-03 | 7.02e-01 |
| Chromosome Maintenance | 68 | 1.04e-05 | 6.17e-05 | 0.4170 | -0.020700 | 0.301000 | 0.221000 | 0.184000 | 7.68e-01 | 1.80e-05 | 1.66e-03 | 8.96e-03 |
| ATF4 activates genes in response to endoplasmic reticulum stress | 24 | 1.21e-02 | 2.76e-02 | 0.4160 | -0.174000 | 0.297000 | 0.230000 | -0.037000 | 1.40e-01 | 1.19e-02 | 5.10e-02 | 7.54e-01 |
| NoRC negatively regulates rRNA expression | 40 | 8.21e-04 | 2.84e-03 | 0.4160 | -0.053200 | 0.367000 | 0.187000 | 0.012500 | 5.61e-01 | 5.96e-05 | 4.10e-02 | 8.91e-01 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 25 | 4.20e-02 | 7.88e-02 | 0.4150 | 0.240000 | 0.061900 | 0.314000 | 0.112000 | 3.81e-02 | 5.92e-01 | 6.61e-03 | 3.31e-01 |
| HDMs demethylate histones | 19 | 1.59e-02 | 3.42e-02 | 0.4150 | -0.300000 | 0.161000 | 0.224000 | -0.079600 | 2.36e-02 | 2.26e-01 | 9.13e-02 | 5.48e-01 |
| Translation of structural proteins | 25 | 5.24e-02 | 9.41e-02 | 0.4150 | 0.163000 | -0.193000 | 0.234000 | 0.231000 | 1.58e-01 | 9.47e-02 | 4.29e-02 | 4.60e-02 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 10 | 2.24e-01 | 3.03e-01 | 0.4140 | -0.140000 | 0.199000 | 0.332000 | 0.046400 | 4.44e-01 | 2.77e-01 | 6.95e-02 | 7.99e-01 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | 10 | 2.24e-01 | 3.03e-01 | 0.4140 | -0.140000 | 0.199000 | 0.332000 | 0.046400 | 4.44e-01 | 2.77e-01 | 6.95e-02 | 7.99e-01 |
| Regulation of TP53 Activity through Methylation | 14 | 4.21e-02 | 7.88e-02 | 0.4130 | 0.148000 | 0.349000 | -0.078500 | -0.146000 | 3.39e-01 | 2.39e-02 | 6.11e-01 | 3.44e-01 |
| Metalloprotease DUBs | 15 | 1.03e-01 | 1.61e-01 | 0.4130 | -0.342000 | 0.223000 | 0.045600 | -0.049200 | 2.20e-02 | 1.35e-01 | 7.60e-01 | 7.42e-01 |
| RHO GTPases activate CIT | 17 | 1.18e-01 | 1.79e-01 | 0.4130 | 0.226000 | -0.151000 | 0.289000 | 0.115000 | 1.06e-01 | 2.81e-01 | 3.91e-02 | 4.13e-01 |
| Interferon Signaling | 119 | 2.40e-07 | 2.20e-06 | 0.4130 | 0.225000 | 0.149000 | 0.240000 | 0.201000 | 2.37e-05 | 5.20e-03 | 6.46e-06 | 1.61e-04 |
| IKK complex recruitment mediated by RIP1 | 14 | 5.69e-02 | 1.01e-01 | 0.4120 | -0.172000 | 0.130000 | 0.351000 | 0.016000 | 2.64e-01 | 3.99e-01 | 2.31e-02 | 9.17e-01 |
| Processing of DNA double-strand break ends | 50 | 1.86e-04 | 7.86e-04 | 0.4120 | -0.085100 | 0.295000 | 0.226000 | 0.156000 | 2.99e-01 | 3.16e-04 | 5.78e-03 | 5.64e-02 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | 25 | 9.63e-03 | 2.28e-02 | 0.4120 | -0.284000 | 0.270000 | 0.122000 | 0.023700 | 1.39e-02 | 1.94e-02 | 2.89e-01 | 8.37e-01 |
| EML4 and NUDC in mitotic spindle formation | 61 | 1.18e-05 | 6.79e-05 | 0.4120 | -0.119000 | 0.326000 | 0.197000 | 0.100000 | 1.09e-01 | 1.06e-05 | 7.99e-03 | 1.77e-01 |
| Hemostasis | 346 | 7.09e-24 | 6.70e-22 | 0.4110 | 0.303000 | -0.136000 | 0.115000 | 0.213000 | 6.94e-22 | 1.63e-05 | 2.81e-04 | 1.34e-11 |
| Pre-NOTCH Processing in Golgi | 14 | 1.03e-01 | 1.61e-01 | 0.4110 | 0.077600 | -0.398000 | 0.061900 | -0.026900 | 6.15e-01 | 1.00e-02 | 6.88e-01 | 8.62e-01 |
| FGFR2 mutant receptor activation | 18 | 6.21e-02 | 1.07e-01 | 0.4100 | -0.058600 | 0.166000 | 0.356000 | 0.102000 | 6.67e-01 | 2.24e-01 | 8.88e-03 | 4.54e-01 |
| Cap-dependent Translation Initiation | 79 | 6.07e-12 | 1.20e-10 | 0.4100 | -0.161000 | 0.068100 | 0.369000 | -0.037300 | 1.38e-02 | 2.96e-01 | 1.46e-08 | 5.67e-01 |
| Eukaryotic Translation Initiation | 79 | 6.07e-12 | 1.20e-10 | 0.4100 | -0.161000 | 0.068100 | 0.369000 | -0.037300 | 1.38e-02 | 2.96e-01 | 1.46e-08 | 5.67e-01 |
| SUMOylation of transcription factors | 14 | 9.20e-02 | 1.47e-01 | 0.4090 | 0.033000 | 0.134000 | 0.385000 | 0.016700 | 8.31e-01 | 3.86e-01 | 1.27e-02 | 9.14e-01 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | 11 | 2.57e-01 | 3.38e-01 | 0.4090 | 0.314000 | -0.202000 | -0.075700 | 0.150000 | 7.19e-02 | 2.47e-01 | 6.64e-01 | 3.90e-01 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | 11 | 2.57e-01 | 3.38e-01 | 0.4090 | 0.314000 | -0.202000 | -0.075700 | 0.150000 | 7.19e-02 | 2.47e-01 | 6.64e-01 | 3.90e-01 |
| Chaperone Mediated Autophagy | 14 | 9.90e-02 | 1.56e-01 | 0.4090 | -0.086100 | -0.054700 | 0.292000 | 0.267000 | 5.77e-01 | 7.23e-01 | 5.87e-02 | 8.35e-02 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 5.44e-02 | 9.74e-02 | 0.4070 | -0.077600 | 0.190000 | 0.287000 | 0.205000 | 5.38e-01 | 1.33e-01 | 2.31e-02 | 1.05e-01 |
| Regulation of IFNG signaling | 13 | 2.41e-01 | 3.21e-01 | 0.4070 | 0.276000 | 0.136000 | 0.255000 | 0.077400 | 8.47e-02 | 3.98e-01 | 1.12e-01 | 6.29e-01 |
| Activation of GABAB receptors | 24 | 9.21e-03 | 2.20e-02 | 0.4070 | 0.224000 | -0.217000 | -0.149000 | 0.214000 | 5.76e-02 | 6.59e-02 | 2.07e-01 | 6.91e-02 |
| GABA B receptor activation | 24 | 9.21e-03 | 2.20e-02 | 0.4070 | 0.224000 | -0.217000 | -0.149000 | 0.214000 | 5.76e-02 | 6.59e-02 | 2.07e-01 | 6.91e-02 |
| PKA activation in glucagon signalling | 14 | 1.58e-01 | 2.26e-01 | 0.4060 | 0.042900 | -0.396000 | -0.070800 | -0.032800 | 7.81e-01 | 1.03e-02 | 6.46e-01 | 8.32e-01 |
| CaM pathway | 27 | 1.40e-02 | 3.08e-02 | 0.4060 | 0.132000 | -0.381000 | -0.044100 | 0.023000 | 2.36e-01 | 6.21e-04 | 6.92e-01 | 8.36e-01 |
| Calmodulin induced events | 27 | 1.40e-02 | 3.08e-02 | 0.4060 | 0.132000 | -0.381000 | -0.044100 | 0.023000 | 2.36e-01 | 6.21e-04 | 6.92e-01 | 8.36e-01 |
| G alpha (z) signalling events | 28 | 1.83e-02 | 3.89e-02 | 0.4060 | 0.289000 | -0.212000 | -0.021000 | 0.190000 | 8.26e-03 | 5.28e-02 | 8.48e-01 | 8.22e-02 |
| DAG and IP3 signaling | 33 | 4.43e-03 | 1.21e-02 | 0.4050 | 0.155000 | -0.353000 | -0.125000 | 0.009530 | 1.24e-01 | 4.48e-04 | 2.15e-01 | 9.25e-01 |
| Transferrin endocytosis and recycling | 21 | 2.12e-02 | 4.40e-02 | 0.4050 | 0.081100 | 0.044800 | 0.059200 | 0.390000 | 5.20e-01 | 7.23e-01 | 6.39e-01 | 1.97e-03 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 11 | 5.33e-01 | 6.13e-01 | 0.4040 | -0.211000 | -0.140000 | -0.219000 | -0.227000 | 2.27e-01 | 4.23e-01 | 2.09e-01 | 1.92e-01 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 24 | 1.55e-02 | 3.35e-02 | 0.4040 | -0.170000 | 0.207000 | 0.254000 | 0.164000 | 1.51e-01 | 7.98e-02 | 3.11e-02 | 1.65e-01 |
| FCGR3A-mediated IL10 synthesis | 25 | 2.39e-02 | 4.83e-02 | 0.4030 | 0.251000 | -0.284000 | -0.075900 | 0.113000 | 2.97e-02 | 1.41e-02 | 5.11e-01 | 3.27e-01 |
| Protein ubiquitination | 56 | 8.71e-06 | 5.22e-05 | 0.4030 | -0.298000 | 0.186000 | 0.124000 | -0.153000 | 1.17e-04 | 1.63e-02 | 1.08e-01 | 4.76e-02 |
| TRAF6 mediated NF-kB activation | 19 | 8.32e-02 | 1.36e-01 | 0.4030 | 0.120000 | -0.134000 | 0.103000 | 0.345000 | 3.66e-01 | 3.13e-01 | 4.38e-01 | 9.18e-03 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | 26 | 9.15e-03 | 2.19e-02 | 0.3980 | -0.286000 | 0.246000 | 0.121000 | 0.039100 | 1.16e-02 | 2.97e-02 | 2.87e-01 | 7.31e-01 |
| Signaling by FGFR3 fusions in cancer | 10 | 2.72e-01 | 3.53e-01 | 0.3980 | -0.319000 | 0.193000 | 0.124000 | -0.063400 | 8.06e-02 | 2.91e-01 | 4.96e-01 | 7.29e-01 |
| Interleukin-12 family signaling | 34 | 2.34e-02 | 4.77e-02 | 0.3980 | 0.231000 | -0.002870 | 0.292000 | 0.140000 | 1.99e-02 | 9.77e-01 | 3.19e-03 | 1.58e-01 |
| Class B/2 (Secretin family receptors) | 33 | 1.59e-03 | 5.02e-03 | 0.3970 | 0.271000 | -0.236000 | -0.155000 | -0.066100 | 7.02e-03 | 1.93e-02 | 1.23e-01 | 5.11e-01 |
| Plasma lipoprotein assembly, remodeling, and clearance | 39 | 2.78e-03 | 8.05e-03 | 0.3970 | 0.220000 | -0.208000 | -0.005590 | 0.257000 | 1.76e-02 | 2.50e-02 | 9.52e-01 | 5.61e-03 |
| GABA receptor activation | 26 | 8.71e-03 | 2.10e-02 | 0.3960 | 0.227000 | -0.226000 | -0.166000 | 0.161000 | 4.49e-02 | 4.59e-02 | 1.43e-01 | 1.55e-01 |
| Acyl chain remodelling of PC | 11 | 1.82e-01 | 2.55e-01 | 0.3940 | 0.333000 | 0.073900 | -0.083200 | 0.180000 | 5.62e-02 | 6.71e-01 | 6.33e-01 | 3.01e-01 |
| Activation of gene expression by SREBF (SREBP) | 40 | 2.97e-03 | 8.58e-03 | 0.3940 | -0.197000 | -0.215000 | -0.076600 | -0.254000 | 3.10e-02 | 1.89e-02 | 4.02e-01 | 5.51e-03 |
| HIV Infection | 187 | 2.88e-18 | 1.69e-16 | 0.3940 | -0.153000 | 0.244000 | 0.265000 | 0.047500 | 3.19e-04 | 1.02e-08 | 4.94e-10 | 2.65e-01 |
| tRNA processing | 98 | 1.59e-08 | 1.69e-07 | 0.3930 | -0.147000 | 0.347000 | 0.100000 | -0.051000 | 1.19e-02 | 3.06e-09 | 8.80e-02 | 3.84e-01 |
| Assembly Of The HIV Virion | 12 | 5.60e-02 | 9.97e-02 | 0.3930 | 0.034900 | -0.146000 | 0.356000 | -0.070200 | 8.34e-01 | 3.80e-01 | 3.25e-02 | 6.74e-01 |
| Activated NOTCH1 Transmits Signal to the Nucleus | 23 | 5.16e-02 | 9.32e-02 | 0.3920 | 0.334000 | -0.032500 | 0.004650 | 0.202000 | 5.60e-03 | 7.87e-01 | 9.69e-01 | 9.39e-02 |
| Misspliced GSK3beta mutants stabilize beta-catenin | 14 | 1.28e-01 | 1.90e-01 | 0.3910 | -0.282000 | 0.203000 | 0.170000 | -0.057200 | 6.81e-02 | 1.88e-01 | 2.71e-01 | 7.11e-01 |
| S33 mutants of beta-catenin aren't phosphorylated | 14 | 1.28e-01 | 1.90e-01 | 0.3910 | -0.282000 | 0.203000 | 0.170000 | -0.057200 | 6.81e-02 | 1.88e-01 | 2.71e-01 | 7.11e-01 |
| S37 mutants of beta-catenin aren't phosphorylated | 14 | 1.28e-01 | 1.90e-01 | 0.3910 | -0.282000 | 0.203000 | 0.170000 | -0.057200 | 6.81e-02 | 1.88e-01 | 2.71e-01 | 7.11e-01 |
| S45 mutants of beta-catenin aren't phosphorylated | 14 | 1.28e-01 | 1.90e-01 | 0.3910 | -0.282000 | 0.203000 | 0.170000 | -0.057200 | 6.81e-02 | 1.88e-01 | 2.71e-01 | 7.11e-01 |
| T41 mutants of beta-catenin aren't phosphorylated | 14 | 1.28e-01 | 1.90e-01 | 0.3910 | -0.282000 | 0.203000 | 0.170000 | -0.057200 | 6.81e-02 | 1.88e-01 | 2.71e-01 | 7.11e-01 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | 14 | 1.28e-01 | 1.90e-01 | 0.3910 | -0.282000 | 0.203000 | 0.170000 | -0.057200 | 6.81e-02 | 1.88e-01 | 2.71e-01 | 7.11e-01 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | 27 | 1.86e-02 | 3.93e-02 | 0.3910 | -0.185000 | 0.335000 | 0.071600 | 0.024800 | 9.63e-02 | 2.56e-03 | 5.20e-01 | 8.23e-01 |
| Nuclear Envelope (NE) Reassembly | 59 | 4.09e-05 | 2.02e-04 | 0.3900 | -0.084900 | 0.174000 | 0.309000 | 0.138000 | 2.60e-01 | 2.12e-02 | 4.02e-05 | 6.74e-02 |
| Stimuli-sensing channels | 42 | 1.08e-03 | 3.62e-03 | 0.3900 | 0.003200 | -0.279000 | -0.272000 | -0.013100 | 9.71e-01 | 1.76e-03 | 2.31e-03 | 8.84e-01 |
| Protein-protein interactions at synapses | 41 | 4.97e-03 | 1.33e-02 | 0.3900 | 0.213000 | -0.198000 | 0.224000 | 0.131000 | 1.83e-02 | 2.84e-02 | 1.32e-02 | 1.47e-01 |
| RHO GTPases activate PAKs | 19 | 7.60e-02 | 1.27e-01 | 0.3900 | 0.191000 | -0.292000 | 0.164000 | 0.055900 | 1.49e-01 | 2.75e-02 | 2.17e-01 | 6.73e-01 |
| RHO GTPases Activate Formins | 80 | 1.62e-05 | 8.96e-05 | 0.3900 | 0.001930 | 0.223000 | 0.267000 | 0.175000 | 9.76e-01 | 5.82e-04 | 3.64e-05 | 6.94e-03 |
| SUMOylation of chromatin organization proteins | 46 | 5.66e-04 | 2.08e-03 | 0.3890 | -0.125000 | 0.333000 | 0.155000 | -0.028600 | 1.43e-01 | 9.36e-05 | 6.94e-02 | 7.38e-01 |
| PKA-mediated phosphorylation of CREB | 17 | 1.22e-01 | 1.85e-01 | 0.3870 | 0.072500 | -0.372000 | -0.072200 | 0.036200 | 6.05e-01 | 7.98e-03 | 6.06e-01 | 7.96e-01 |
| Signaling by Non-Receptor Tyrosine Kinases | 42 | 3.01e-02 | 5.92e-02 | 0.3870 | 0.223000 | -0.050400 | 0.219000 | 0.222000 | 1.25e-02 | 5.72e-01 | 1.41e-02 | 1.28e-02 |
| Signaling by PTK6 | 42 | 3.01e-02 | 5.92e-02 | 0.3870 | 0.223000 | -0.050400 | 0.219000 | 0.222000 | 1.25e-02 | 5.72e-01 | 1.41e-02 | 1.28e-02 |
| Telomere C-strand synthesis initiation | 11 | 3.06e-01 | 3.89e-01 | 0.3860 | 0.146000 | 0.261000 | 0.047200 | 0.238000 | 4.01e-01 | 1.34e-01 | 7.86e-01 | 1.71e-01 |
| Resolution of D-Loop Structures | 21 | 7.64e-02 | 1.28e-01 | 0.3860 | 0.135000 | 0.118000 | 0.081400 | 0.332000 | 2.85e-01 | 3.50e-01 | 5.19e-01 | 8.56e-03 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 21 | 7.64e-02 | 1.28e-01 | 0.3860 | 0.135000 | 0.118000 | 0.081400 | 0.332000 | 2.85e-01 | 3.50e-01 | 5.19e-01 | 8.56e-03 |
| Interleukin-12 signaling | 29 | 3.84e-02 | 7.35e-02 | 0.3850 | 0.228000 | -0.004150 | 0.293000 | 0.105000 | 3.41e-02 | 9.69e-01 | 6.42e-03 | 3.28e-01 |
| IRE1alpha activates chaperones | 47 | 2.65e-03 | 7.77e-03 | 0.3850 | 0.130000 | 0.012600 | 0.335000 | 0.138000 | 1.24e-01 | 8.82e-01 | 7.28e-05 | 1.02e-01 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 75 | 5.85e-10 | 7.91e-09 | 0.3850 | -0.118000 | 0.065600 | 0.358000 | -0.041700 | 7.74e-02 | 3.27e-01 | 8.65e-08 | 5.33e-01 |
| Nonsense-Mediated Decay (NMD) | 75 | 5.85e-10 | 7.91e-09 | 0.3850 | -0.118000 | 0.065600 | 0.358000 | -0.041700 | 7.74e-02 | 3.27e-01 | 8.65e-08 | 5.33e-01 |
| Cellular response to heat stress | 82 | 6.21e-08 | 6.21e-07 | 0.3840 | -0.187000 | 0.231000 | 0.243000 | 0.007940 | 3.45e-03 | 3.04e-04 | 1.45e-04 | 9.01e-01 |
| p38MAPK events | 12 | 2.75e-01 | 3.56e-01 | 0.3840 | 0.119000 | -0.365000 | -0.006560 | 0.008710 | 4.76e-01 | 2.87e-02 | 9.69e-01 | 9.58e-01 |
| RUNX2 regulates osteoblast differentiation | 20 | 6.22e-02 | 1.07e-01 | 0.3820 | 0.342000 | -0.040800 | -0.041700 | 0.160000 | 8.07e-03 | 7.52e-01 | 7.47e-01 | 2.15e-01 |
| Nuclear Envelope Breakdown | 42 | 1.44e-03 | 4.61e-03 | 0.3820 | -0.168000 | 0.303000 | 0.151000 | 0.055000 | 5.95e-02 | 6.77e-04 | 9.11e-02 | 5.38e-01 |
| Translesion synthesis by POLI | 15 | 1.44e-01 | 2.09e-01 | 0.3820 | -0.107000 | 0.309000 | 0.089200 | 0.176000 | 4.74e-01 | 3.83e-02 | 5.50e-01 | 2.37e-01 |
| Frs2-mediated activation | 10 | 1.20e-01 | 1.82e-01 | 0.3820 | -0.015700 | 0.139000 | 0.301000 | -0.190000 | 9.32e-01 | 4.48e-01 | 9.95e-02 | 2.99e-01 |
| RNA Polymerase III Chain Elongation | 17 | 1.16e-01 | 1.77e-01 | 0.3820 | -0.200000 | 0.298000 | 0.119000 | 0.056400 | 1.54e-01 | 3.35e-02 | 3.98e-01 | 6.87e-01 |
| Plasma lipoprotein clearance | 21 | 1.39e-01 | 2.02e-01 | 0.3810 | 0.184000 | -0.110000 | 0.088600 | 0.302000 | 1.45e-01 | 3.84e-01 | 4.82e-01 | 1.67e-02 |
| Adenylate cyclase inhibitory pathway | 11 | 2.08e-01 | 2.85e-01 | 0.3800 | 0.063300 | -0.228000 | -0.038000 | 0.296000 | 7.16e-01 | 1.91e-01 | 8.28e-01 | 8.96e-02 |
| Deadenylation of mRNA | 24 | 5.16e-02 | 9.32e-02 | 0.3800 | -0.179000 | 0.317000 | 0.047400 | -0.096700 | 1.28e-01 | 7.14e-03 | 6.88e-01 | 4.12e-01 |
| SHC-mediated cascade:FGFR2 | 10 | 6.23e-01 | 6.98e-01 | 0.3800 | 0.180000 | -0.090900 | 0.213000 | 0.241000 | 3.25e-01 | 6.19e-01 | 2.43e-01 | 1.87e-01 |
| Signaling by PDGF | 46 | 7.74e-03 | 1.91e-02 | 0.3780 | 0.261000 | -0.181000 | 0.118000 | 0.168000 | 2.20e-03 | 3.39e-02 | 1.67e-01 | 4.84e-02 |
| Cell junction organization | 45 | 4.18e-03 | 1.16e-02 | 0.3780 | 0.264000 | -0.228000 | 0.052300 | 0.137000 | 2.21e-03 | 8.21e-03 | 5.44e-01 | 1.13e-01 |
| Mitotic Prophase | 70 | 5.41e-06 | 3.55e-05 | 0.3780 | -0.180000 | 0.274000 | 0.171000 | 0.079000 | 9.15e-03 | 7.65e-05 | 1.37e-02 | 2.54e-01 |
| TP53 Regulates Transcription of DNA Repair Genes | 51 | 5.55e-04 | 2.05e-03 | 0.3770 | -0.050000 | 0.323000 | 0.188000 | 0.018600 | 5.37e-01 | 6.76e-05 | 2.04e-02 | 8.18e-01 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 19 | 1.31e-01 | 1.93e-01 | 0.3770 | 0.139000 | 0.191000 | 0.289000 | 0.055000 | 2.95e-01 | 1.49e-01 | 2.93e-02 | 6.79e-01 |
| Interleukin-6 family signaling | 16 | 2.55e-01 | 3.37e-01 | 0.3770 | 0.231000 | -0.246000 | 0.059000 | 0.158000 | 1.10e-01 | 8.90e-02 | 6.83e-01 | 2.73e-01 |
| RNA Polymerase III Transcription Initiation | 34 | 5.03e-03 | 1.34e-02 | 0.3760 | -0.241000 | 0.273000 | 0.089600 | 0.036500 | 1.51e-02 | 5.98e-03 | 3.67e-01 | 7.13e-01 |
| SUMOylation of DNA damage response and repair proteins | 62 | 6.86e-05 | 3.27e-04 | 0.3760 | -0.132000 | 0.319000 | 0.146000 | 0.031400 | 7.17e-02 | 1.46e-05 | 4.75e-02 | 6.69e-01 |
| Signalling to RAS | 16 | 1.28e-01 | 1.91e-01 | 0.3760 | 0.156000 | -0.327000 | 0.100000 | 0.001520 | 2.80e-01 | 2.37e-02 | 4.88e-01 | 9.92e-01 |
| Translesion synthesis by POLK | 15 | 1.29e-01 | 1.91e-01 | 0.3750 | -0.166000 | 0.318000 | 0.003730 | 0.110000 | 2.67e-01 | 3.29e-02 | 9.80e-01 | 4.61e-01 |
| MTOR signalling | 40 | 1.07e-02 | 2.51e-02 | 0.3750 | -0.311000 | -0.078900 | -0.145000 | -0.128000 | 6.79e-04 | 3.89e-01 | 1.12e-01 | 1.61e-01 |
| Ca-dependent events | 29 | 2.30e-02 | 4.71e-02 | 0.3750 | 0.166000 | -0.334000 | -0.020600 | 0.028600 | 1.21e-01 | 1.88e-03 | 8.48e-01 | 7.90e-01 |
| Meiotic recombination | 17 | 8.28e-02 | 1.36e-01 | 0.3740 | -0.011900 | 0.320000 | 0.009500 | 0.194000 | 9.32e-01 | 2.25e-02 | 9.46e-01 | 1.66e-01 |
| Diseases associated with N-glycosylation of proteins | 16 | 1.88e-01 | 2.62e-01 | 0.3740 | 0.293000 | 0.130000 | 0.182000 | 0.064800 | 4.26e-02 | 3.67e-01 | 2.08e-01 | 6.54e-01 |
| Degradation of AXIN | 47 | 1.62e-05 | 8.96e-05 | 0.3740 | -0.245000 | 0.101000 | 0.239000 | -0.113000 | 3.74e-03 | 2.30e-01 | 4.67e-03 | 1.81e-01 |
| G alpha (q) signalling events | 78 | 2.30e-06 | 1.61e-05 | 0.3730 | 0.328000 | -0.141000 | -0.036100 | 0.103000 | 5.88e-07 | 3.21e-02 | 5.82e-01 | 1.16e-01 |
| Transport of vitamins, nucleosides, and related molecules | 24 | 1.13e-01 | 1.74e-01 | 0.3720 | 0.212000 | -0.206000 | 0.069700 | 0.216000 | 7.25e-02 | 8.15e-02 | 5.55e-01 | 6.69e-02 |
| Host Interactions of HIV factors | 102 | 5.04e-09 | 6.14e-08 | 0.3720 | -0.136000 | 0.179000 | 0.283000 | 0.089500 | 1.79e-02 | 1.87e-03 | 8.10e-07 | 1.19e-01 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 48 | 3.55e-05 | 1.78e-04 | 0.3720 | -0.147000 | 0.107000 | 0.324000 | 0.018500 | 7.92e-02 | 1.98e-01 | 1.02e-04 | 8.24e-01 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 46 | 1.83e-05 | 9.93e-05 | 0.3720 | -0.219000 | 0.096900 | 0.273000 | -0.077700 | 1.02e-02 | 2.56e-01 | 1.35e-03 | 3.63e-01 |
| PIWI-interacting RNA (piRNA) biogenesis | 13 | 2.29e-01 | 3.08e-01 | 0.3710 | -0.112000 | 0.246000 | 0.254000 | -0.006890 | 4.83e-01 | 1.25e-01 | 1.13e-01 | 9.66e-01 |
| O-linked glycosylation of mucins | 21 | 1.62e-01 | 2.31e-01 | 0.3710 | 0.101000 | -0.140000 | 0.225000 | 0.239000 | 4.23e-01 | 2.67e-01 | 7.40e-02 | 5.86e-02 |
| L1CAM interactions | 69 | 3.51e-04 | 1.36e-03 | 0.3700 | 0.268000 | -0.149000 | 0.054000 | 0.200000 | 1.19e-04 | 3.28e-02 | 4.39e-01 | 4.20e-03 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 28 | 1.23e-02 | 2.80e-02 | 0.3700 | -0.011700 | 0.174000 | 0.326000 | 0.004250 | 9.14e-01 | 1.12e-01 | 2.81e-03 | 9.69e-01 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 27 | 8.54e-03 | 2.09e-02 | 0.3700 | 0.349000 | -0.100000 | -0.070100 | -0.002630 | 1.71e-03 | 3.68e-01 | 5.29e-01 | 9.81e-01 |
| Triglyceride metabolism | 20 | 8.02e-02 | 1.32e-01 | 0.3700 | 0.107000 | -0.163000 | -0.295000 | -0.109000 | 4.07e-01 | 2.08e-01 | 2.26e-02 | 3.98e-01 |
| Intrinsic Pathway for Apoptosis | 41 | 2.37e-02 | 4.81e-02 | 0.3690 | 0.133000 | -0.092200 | 0.252000 | 0.216000 | 1.41e-01 | 3.07e-01 | 5.25e-03 | 1.69e-02 |
| ADORA2B mediated anti-inflammatory cytokines production | 38 | 5.38e-03 | 1.41e-02 | 0.3690 | 0.315000 | -0.139000 | -0.036200 | 0.129000 | 7.82e-04 | 1.40e-01 | 7.00e-01 | 1.70e-01 |
| RNA Polymerase I Promoter Escape | 25 | 3.86e-02 | 7.37e-02 | 0.3680 | -0.087500 | 0.293000 | 0.202000 | -0.036300 | 4.49e-01 | 1.14e-02 | 8.11e-02 | 7.54e-01 |
| Spry regulation of FGF signaling | 14 | 1.77e-01 | 2.49e-01 | 0.3670 | 0.211000 | 0.025500 | 0.299000 | 0.007260 | 1.71e-01 | 8.69e-01 | 5.25e-02 | 9.62e-01 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | 10 | 2.69e-01 | 3.50e-01 | 0.3670 | 0.133000 | -0.311000 | 0.071400 | -0.123000 | 4.66e-01 | 8.82e-02 | 6.96e-01 | 5.01e-01 |
| Antiviral mechanism by IFN-stimulated genes | 64 | 1.58e-04 | 6.78e-04 | 0.3660 | -0.017700 | 0.283000 | 0.227000 | 0.050100 | 8.07e-01 | 9.46e-05 | 1.69e-03 | 4.89e-01 |
| Signaling by BMP | 22 | 3.11e-03 | 8.93e-03 | 0.3660 | 0.030200 | -0.055200 | 0.085100 | -0.351000 | 8.06e-01 | 6.54e-01 | 4.90e-01 | 4.42e-03 |
| DAP12 interactions | 15 | 4.01e-01 | 4.84e-01 | 0.3650 | 0.133000 | 0.026900 | 0.161000 | 0.299000 | 3.72e-01 | 8.57e-01 | 2.81e-01 | 4.52e-02 |
| DAP12 signaling | 15 | 4.01e-01 | 4.84e-01 | 0.3650 | 0.133000 | 0.026900 | 0.161000 | 0.299000 | 3.72e-01 | 8.57e-01 | 2.81e-01 | 4.52e-02 |
| Downstream TCR signaling | 67 | 1.95e-07 | 1.82e-06 | 0.3650 | -0.262000 | 0.086900 | 0.220000 | -0.095900 | 2.16e-04 | 2.19e-01 | 1.91e-03 | 1.76e-01 |
| Early Phase of HIV Life Cycle | 11 | 3.42e-01 | 4.29e-01 | 0.3650 | -0.124000 | 0.149000 | 0.264000 | 0.162000 | 4.76e-01 | 3.91e-01 | 1.30e-01 | 3.53e-01 |
| Translesion synthesis by REV1 | 14 | 1.84e-01 | 2.56e-01 | 0.3650 | -0.140000 | 0.291000 | 0.061600 | 0.158000 | 3.65e-01 | 5.95e-02 | 6.90e-01 | 3.06e-01 |
| SUMOylation of transcription cofactors | 38 | 6.73e-03 | 1.70e-02 | 0.3630 | -0.165000 | 0.229000 | 0.022800 | -0.227000 | 7.80e-02 | 1.47e-02 | 8.08e-01 | 1.54e-02 |
| Mitotic Spindle Checkpoint | 74 | 1.69e-05 | 9.20e-05 | 0.3630 | -0.131000 | 0.302000 | 0.134000 | 0.071000 | 5.13e-02 | 7.15e-06 | 4.58e-02 | 2.92e-01 |
| Inhibition of DNA recombination at telomere | 19 | 1.97e-01 | 2.73e-01 | 0.3630 | 0.022200 | 0.290000 | 0.192000 | 0.101000 | 8.67e-01 | 2.87e-02 | 1.47e-01 | 4.47e-01 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 32 | 1.10e-01 | 1.70e-01 | 0.3620 | 0.202000 | -0.099000 | 0.188000 | 0.213000 | 4.81e-02 | 3.33e-01 | 6.63e-02 | 3.74e-02 |
| Recognition of DNA damage by PCNA-containing replication complex | 28 | 3.93e-02 | 7.49e-02 | 0.3620 | -0.105000 | 0.252000 | 0.200000 | 0.126000 | 3.36e-01 | 2.10e-02 | 6.65e-02 | 2.49e-01 |
| CDT1 association with the CDC6:ORC:origin complex | 48 | 9.70e-05 | 4.46e-04 | 0.3610 | -0.280000 | 0.120000 | 0.182000 | -0.069100 | 8.11e-04 | 1.51e-01 | 2.93e-02 | 4.08e-01 |
| Visual phototransduction | 37 | 2.35e-02 | 4.80e-02 | 0.3610 | 0.142000 | -0.217000 | 0.171000 | 0.183000 | 1.34e-01 | 2.23e-02 | 7.26e-02 | 5.41e-02 |
| KSRP (KHSRP) binds and destabilizes mRNA | 16 | 2.33e-01 | 3.12e-01 | 0.3600 | -0.039600 | 0.317000 | 0.164000 | 0.027300 | 7.84e-01 | 2.83e-02 | 2.57e-01 | 8.50e-01 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 42 | 1.27e-04 | 5.67e-04 | 0.3600 | -0.233000 | 0.084700 | 0.255000 | -0.051800 | 9.02e-03 | 3.43e-01 | 4.23e-03 | 5.62e-01 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 18 | 2.32e-01 | 3.11e-01 | 0.3590 | 0.066100 | -0.084100 | 0.190000 | 0.285000 | 6.27e-01 | 5.37e-01 | 1.62e-01 | 3.61e-02 |
| Neurodegenerative Diseases | 18 | 2.32e-01 | 3.11e-01 | 0.3590 | 0.066100 | -0.084100 | 0.190000 | 0.285000 | 6.27e-01 | 5.37e-01 | 1.62e-01 | 3.61e-02 |
| Vpu mediated degradation of CD4 | 43 | 1.44e-04 | 6.32e-04 | 0.3590 | -0.266000 | 0.081100 | 0.205000 | -0.099000 | 2.60e-03 | 3.58e-01 | 1.99e-02 | 2.62e-01 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | 21 | 1.41e-01 | 2.06e-01 | 0.3590 | 0.283000 | -0.178000 | 0.003130 | 0.132000 | 2.49e-02 | 1.59e-01 | 9.80e-01 | 2.96e-01 |
| XBP1(S) activates chaperone genes | 45 | 5.40e-03 | 1.41e-02 | 0.3590 | 0.124000 | -0.003280 | 0.319000 | 0.110000 | 1.52e-01 | 9.70e-01 | 2.20e-04 | 2.02e-01 |
| tRNA modification in the nucleus and cytosol | 38 | 8.57e-03 | 2.09e-02 | 0.3580 | -0.032700 | 0.323000 | 0.152000 | -0.007180 | 7.27e-01 | 5.86e-04 | 1.05e-01 | 9.39e-01 |
| Telomere Extension By Telomerase | 19 | 1.08e-01 | 1.67e-01 | 0.3580 | 0.126000 | 0.325000 | 0.075800 | 0.028800 | 3.40e-01 | 1.42e-02 | 5.68e-01 | 8.28e-01 |
| G alpha (12/13) signalling events | 54 | 1.19e-03 | 3.89e-03 | 0.3580 | 0.232000 | -0.231000 | -0.029900 | 0.140000 | 3.20e-03 | 3.29e-03 | 7.04e-01 | 7.54e-02 |
| Orc1 removal from chromatin | 59 | 7.51e-06 | 4.68e-05 | 0.3580 | -0.211000 | 0.115000 | 0.263000 | 0.034600 | 5.13e-03 | 1.27e-01 | 4.86e-04 | 6.47e-01 |
| Rap1 signalling | 14 | 4.70e-01 | 5.54e-01 | 0.3570 | 0.260000 | 0.078800 | 0.177000 | 0.151000 | 9.23e-02 | 6.10e-01 | 2.51e-01 | 3.30e-01 |
| Sialic acid metabolism | 23 | 9.05e-02 | 1.46e-01 | 0.3570 | 0.118000 | -0.301000 | 0.020900 | 0.149000 | 3.29e-01 | 1.25e-02 | 8.62e-01 | 2.16e-01 |
| NIK-->noncanonical NF-kB signaling | 50 | 2.48e-05 | 1.29e-04 | 0.3560 | -0.254000 | 0.077900 | 0.232000 | -0.047700 | 1.91e-03 | 3.41e-01 | 4.57e-03 | 5.60e-01 |
| Initiation of Nuclear Envelope (NE) Reformation | 17 | 1.08e-01 | 1.67e-01 | 0.3550 | -0.109000 | 0.196000 | 0.273000 | -0.037300 | 4.37e-01 | 1.61e-01 | 5.18e-02 | 7.90e-01 |
| mRNA decay by 3' to 5' exoribonuclease | 15 | 1.65e-01 | 2.35e-01 | 0.3550 | -0.150000 | 0.233000 | 0.180000 | -0.130000 | 3.15e-01 | 1.19e-01 | 2.27e-01 | 3.85e-01 |
| Aquaporin-mediated transport | 29 | 1.87e-02 | 3.95e-02 | 0.3540 | 0.228000 | -0.215000 | -0.164000 | -0.022300 | 3.40e-02 | 4.51e-02 | 1.27e-01 | 8.35e-01 |
| DNA Replication Pre-Initiation | 70 | 3.44e-06 | 2.32e-05 | 0.3530 | -0.186000 | 0.140000 | 0.250000 | 0.090700 | 7.18e-03 | 4.37e-02 | 3.03e-04 | 1.90e-01 |
| Vif-mediated degradation of APOBEC3G | 43 | 2.09e-04 | 8.61e-04 | 0.3530 | -0.259000 | 0.085600 | 0.210000 | -0.077700 | 3.35e-03 | 3.32e-01 | 1.72e-02 | 3.79e-01 |
| Epigenetic regulation of gene expression | 79 | 1.42e-05 | 8.06e-05 | 0.3520 | -0.076200 | 0.279000 | 0.201000 | 0.007730 | 2.43e-01 | 1.85e-05 | 2.03e-03 | 9.06e-01 |
| Regulation of Apoptosis | 45 | 1.51e-04 | 6.57e-04 | 0.3520 | -0.274000 | 0.078300 | 0.195000 | -0.068600 | 1.46e-03 | 3.64e-01 | 2.37e-02 | 4.26e-01 |
| Glucagon signaling in metabolic regulation | 23 | 8.68e-02 | 1.41e-01 | 0.3520 | 0.199000 | -0.274000 | -0.091700 | 0.034500 | 9.84e-02 | 2.32e-02 | 4.47e-01 | 7.74e-01 |
| PLC beta mediated events | 39 | 1.15e-02 | 2.65e-02 | 0.3520 | 0.207000 | -0.260000 | -0.044000 | 0.107000 | 2.51e-02 | 5.05e-03 | 6.35e-01 | 2.47e-01 |
| FCERI mediated NF-kB activation | 65 | 1.19e-06 | 9.08e-06 | 0.3520 | -0.275000 | 0.045600 | 0.177000 | -0.120000 | 1.27e-04 | 5.26e-01 | 1.36e-02 | 9.39e-02 |
| SCF-beta-TrCP mediated degradation of Emi1 | 45 | 1.07e-04 | 4.87e-04 | 0.3520 | -0.263000 | 0.061800 | 0.205000 | -0.092000 | 2.31e-03 | 4.74e-01 | 1.72e-02 | 2.86e-01 |
| Dectin-1 mediated noncanonical NF-kB signaling | 51 | 2.82e-05 | 1.46e-04 | 0.3510 | -0.234000 | 0.084100 | 0.244000 | -0.039600 | 3.94e-03 | 2.99e-01 | 2.55e-03 | 6.26e-01 |
| Processive synthesis on the C-strand of the telomere | 19 | 3.70e-01 | 4.54e-01 | 0.3500 | 0.113000 | 0.110000 | 0.195000 | 0.244000 | 3.95e-01 | 4.08e-01 | 1.40e-01 | 6.52e-02 |
| Thromboxane signalling through TP receptor | 14 | 3.63e-01 | 4.49e-01 | 0.3500 | 0.270000 | 0.055300 | 0.037400 | 0.213000 | 8.09e-02 | 7.20e-01 | 8.09e-01 | 1.67e-01 |
| Nuclear Events (kinase and transcription factor activation) | 52 | 3.61e-03 | 1.02e-02 | 0.3500 | 0.202000 | -0.110000 | 0.244000 | 0.100000 | 1.19e-02 | 1.69e-01 | 2.34e-03 | 2.12e-01 |
| Synthesis of substrates in N-glycan biosythesis | 52 | 2.01e-02 | 4.18e-02 | 0.3500 | 0.217000 | -0.107000 | 0.164000 | 0.192000 | 6.77e-03 | 1.84e-01 | 4.09e-02 | 1.66e-02 |
| Innate Immune System | 606 | 1.51e-26 | 2.32e-24 | 0.3500 | 0.166000 | -0.042800 | 0.165000 | 0.257000 | 6.72e-12 | 7.63e-02 | 7.54e-12 | 1.66e-26 |
| ISG15 antiviral mechanism | 59 | 5.42e-04 | 2.01e-03 | 0.3490 | -0.050200 | 0.271000 | 0.213000 | 0.025400 | 5.05e-01 | 3.18e-04 | 4.80e-03 | 7.37e-01 |
| Amino acid transport across the plasma membrane | 20 | 1.44e-01 | 2.09e-01 | 0.3490 | 0.096100 | -0.303000 | 0.071600 | 0.126000 | 4.57e-01 | 1.92e-02 | 5.80e-01 | 3.31e-01 |
| PI-3K cascade:FGFR3 | 10 | 3.09e-01 | 3.92e-01 | 0.3490 | -0.215000 | 0.065600 | 0.133000 | -0.231000 | 2.39e-01 | 7.19e-01 | 4.66e-01 | 2.06e-01 |
| HCMV Late Events | 43 | 1.98e-03 | 6.03e-03 | 0.3490 | -0.258000 | 0.221000 | 0.070600 | 0.033400 | 3.45e-03 | 1.23e-02 | 4.24e-01 | 7.05e-01 |
| Regulation of signaling by CBL | 13 | 4.61e-01 | 5.44e-01 | 0.3480 | 0.097400 | 0.033900 | 0.304000 | 0.136000 | 5.43e-01 | 8.33e-01 | 5.80e-02 | 3.97e-01 |
| Uptake and function of anthrax toxins | 11 | 3.29e-01 | 4.14e-01 | 0.3470 | 0.047800 | -0.224000 | -0.065900 | -0.253000 | 7.84e-01 | 1.99e-01 | 7.05e-01 | 1.47e-01 |
| ATF6 (ATF6-alpha) activates chaperones | 12 | 3.76e-01 | 4.60e-01 | 0.3460 | -0.037100 | 0.107000 | 0.310000 | 0.104000 | 8.24e-01 | 5.23e-01 | 6.28e-02 | 5.35e-01 |
| Prolonged ERK activation events | 12 | 2.13e-01 | 2.91e-01 | 0.3460 | -0.043500 | 0.220000 | 0.215000 | -0.152000 | 7.94e-01 | 1.87e-01 | 1.96e-01 | 3.63e-01 |
| G beta:gamma signalling through PI3Kgamma | 15 | 2.54e-01 | 3.36e-01 | 0.3460 | 0.288000 | -0.061800 | -0.043900 | 0.175000 | 5.32e-02 | 6.79e-01 | 7.69e-01 | 2.40e-01 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 43 | 2.87e-04 | 1.15e-03 | 0.3460 | -0.217000 | 0.101000 | 0.243000 | -0.056500 | 1.40e-02 | 2.52e-01 | 5.80e-03 | 5.22e-01 |
| p53-Independent DNA Damage Response | 43 | 2.87e-04 | 1.15e-03 | 0.3460 | -0.217000 | 0.101000 | 0.243000 | -0.056500 | 1.40e-02 | 2.52e-01 | 5.80e-03 | 5.22e-01 |
| p53-Independent G1/S DNA damage checkpoint | 43 | 2.87e-04 | 1.15e-03 | 0.3460 | -0.217000 | 0.101000 | 0.243000 | -0.056500 | 1.40e-02 | 2.52e-01 | 5.80e-03 | 5.22e-01 |
| Regulation of insulin secretion | 46 | 3.72e-03 | 1.05e-02 | 0.3450 | 0.303000 | -0.116000 | -0.023900 | 0.115000 | 3.82e-04 | 1.72e-01 | 7.80e-01 | 1.79e-01 |
| Disorders of Developmental Biology | 10 | 7.28e-01 | 7.80e-01 | 0.3450 | -0.217000 | -0.040800 | -0.158000 | -0.212000 | 2.34e-01 | 8.23e-01 | 3.86e-01 | 2.46e-01 |
| Disorders of Nervous System Development | 10 | 7.28e-01 | 7.80e-01 | 0.3450 | -0.217000 | -0.040800 | -0.158000 | -0.212000 | 2.34e-01 | 8.23e-01 | 3.86e-01 | 2.46e-01 |
| Loss of function of MECP2 in Rett syndrome | 10 | 7.28e-01 | 7.80e-01 | 0.3450 | -0.217000 | -0.040800 | -0.158000 | -0.212000 | 2.34e-01 | 8.23e-01 | 3.86e-01 | 2.46e-01 |
| Pervasive developmental disorders | 10 | 7.28e-01 | 7.80e-01 | 0.3450 | -0.217000 | -0.040800 | -0.158000 | -0.212000 | 2.34e-01 | 8.23e-01 | 3.86e-01 | 2.46e-01 |
| Ubiquitin-dependent degradation of Cyclin D | 44 | 1.98e-04 | 8.18e-04 | 0.3450 | -0.211000 | 0.087000 | 0.254000 | -0.046300 | 1.57e-02 | 3.19e-01 | 3.57e-03 | 5.96e-01 |
| RHO GTPase Effectors | 173 | 2.34e-07 | 2.16e-06 | 0.3440 | 0.106000 | 0.072100 | 0.247000 | 0.203000 | 1.67e-02 | 1.03e-01 | 2.37e-08 | 4.40e-06 |
| Peptide hormone metabolism | 39 | 5.61e-03 | 1.45e-02 | 0.3440 | 0.099500 | 0.011500 | 0.043900 | 0.326000 | 2.83e-01 | 9.01e-01 | 6.35e-01 | 4.25e-04 |
| VEGFR2 mediated cell proliferation | 16 | 1.98e-01 | 2.74e-01 | 0.3440 | 0.261000 | -0.158000 | -0.105000 | 0.120000 | 7.11e-02 | 2.74e-01 | 4.66e-01 | 4.08e-01 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 29 | 1.03e-01 | 1.61e-01 | 0.3440 | -0.277000 | -0.077100 | -0.142000 | -0.124000 | 9.97e-03 | 4.73e-01 | 1.85e-01 | 2.46e-01 |
| Assembly of the pre-replicative complex | 56 | 2.72e-05 | 1.41e-04 | 0.3440 | -0.212000 | 0.095100 | 0.252000 | 0.026100 | 6.10e-03 | 2.19e-01 | 1.13e-03 | 7.36e-01 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 18 | 1.75e-01 | 2.48e-01 | 0.3430 | 0.122000 | -0.006560 | 0.315000 | 0.061500 | 3.69e-01 | 9.62e-01 | 2.09e-02 | 6.52e-01 |
| mTORC1-mediated signalling | 23 | 7.73e-02 | 1.29e-01 | 0.3430 | -0.332000 | -0.021600 | -0.037800 | -0.075100 | 5.86e-03 | 8.58e-01 | 7.54e-01 | 5.33e-01 |
| Metabolic disorders of biological oxidation enzymes | 13 | 2.67e-01 | 3.47e-01 | 0.3430 | -0.203000 | -0.180000 | 0.020700 | -0.209000 | 2.06e-01 | 2.62e-01 | 8.97e-01 | 1.92e-01 |
| GPCR downstream signalling | 243 | 6.61e-14 | 1.94e-12 | 0.3420 | 0.234000 | -0.204000 | 0.016900 | 0.143000 | 3.85e-10 | 5.49e-08 | 6.53e-01 | 1.29e-04 |
| Signaling by MET | 52 | 2.64e-02 | 5.29e-02 | 0.3420 | 0.127000 | 0.012700 | 0.251000 | 0.194000 | 1.14e-01 | 8.75e-01 | 1.73e-03 | 1.58e-02 |
| NRAGE signals death through JNK | 43 | 7.38e-03 | 1.84e-02 | 0.3420 | 0.125000 | -0.300000 | -0.050800 | 0.092900 | 1.58e-01 | 6.72e-04 | 5.65e-01 | 2.93e-01 |
| Homologous DNA Pairing and Strand Exchange | 30 | 2.69e-02 | 5.37e-02 | 0.3410 | 0.002620 | 0.253000 | 0.060700 | 0.220000 | 9.80e-01 | 1.63e-02 | 5.66e-01 | 3.73e-02 |
| G-protein mediated events | 40 | 1.40e-02 | 3.08e-02 | 0.3410 | 0.177000 | -0.268000 | -0.042000 | 0.106000 | 5.25e-02 | 3.43e-03 | 6.46e-01 | 2.46e-01 |
| Glutathione conjugation | 21 | 2.38e-01 | 3.19e-01 | 0.3400 | -0.101000 | -0.252000 | -0.155000 | -0.134000 | 4.25e-01 | 4.53e-02 | 2.18e-01 | 2.90e-01 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 13 | 3.89e-01 | 4.72e-01 | 0.3400 | 0.097600 | -0.079100 | 0.295000 | 0.112000 | 5.43e-01 | 6.22e-01 | 6.55e-02 | 4.83e-01 |
| DNA Damage Recognition in GG-NER | 34 | 3.52e-02 | 6.85e-02 | 0.3390 | -0.197000 | 0.170000 | 0.008250 | -0.218000 | 4.72e-02 | 8.60e-02 | 9.34e-01 | 2.81e-02 |
| Retrograde transport at the Trans-Golgi-Network | 43 | 1.29e-02 | 2.89e-02 | 0.3390 | -0.243000 | 0.191000 | -0.120000 | -0.072100 | 5.93e-03 | 3.02e-02 | 1.73e-01 | 4.14e-01 |
| Dual incision in TC-NER | 60 | 4.36e-04 | 1.66e-03 | 0.3390 | -0.190000 | 0.250000 | 0.124000 | -0.033800 | 1.09e-02 | 8.26e-04 | 9.85e-02 | 6.51e-01 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 46 | 3.36e-04 | 1.32e-03 | 0.3390 | -0.258000 | 0.090900 | 0.183000 | -0.082400 | 2.53e-03 | 2.87e-01 | 3.16e-02 | 3.34e-01 |
| G2/M Checkpoints | 106 | 1.90e-07 | 1.81e-06 | 0.3390 | -0.123000 | 0.171000 | 0.243000 | 0.106000 | 2.97e-02 | 2.35e-03 | 1.58e-05 | 5.93e-02 |
| G alpha (s) signalling events | 51 | 1.65e-03 | 5.14e-03 | 0.3390 | 0.250000 | -0.161000 | -0.076400 | 0.143000 | 2.01e-03 | 4.70e-02 | 3.46e-01 | 7.87e-02 |
| Metabolism of porphyrins | 18 | 2.64e-01 | 3.45e-01 | 0.3380 | -0.047800 | -0.143000 | -0.290000 | -0.085400 | 7.26e-01 | 2.93e-01 | 3.30e-02 | 5.31e-01 |
| Signaling by GPCR | 268 | 4.92e-15 | 1.78e-13 | 0.3380 | 0.234000 | -0.208000 | 0.020100 | 0.125000 | 5.40e-11 | 6.15e-09 | 5.74e-01 | 4.55e-04 |
| G alpha (i) signalling events | 125 | 1.06e-06 | 8.33e-06 | 0.3370 | 0.209000 | -0.221000 | 0.048200 | 0.138000 | 5.62e-05 | 2.16e-05 | 3.54e-01 | 7.83e-03 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | 56 | 1.15e-03 | 3.81e-03 | 0.3370 | 0.070300 | -0.315000 | -0.077500 | 0.055300 | 3.63e-01 | 4.60e-05 | 3.17e-01 | 4.75e-01 |
| Nucleotide salvage | 18 | 1.79e-01 | 2.51e-01 | 0.3370 | 0.060300 | -0.307000 | 0.090900 | 0.084400 | 6.58e-01 | 2.42e-02 | 5.05e-01 | 5.35e-01 |
| Nonhomologous End-Joining (NHEJ) | 30 | 4.56e-02 | 8.43e-02 | 0.3360 | -0.196000 | 0.271000 | -0.028000 | -0.017400 | 6.37e-02 | 1.01e-02 | 7.91e-01 | 8.69e-01 |
| Negative regulation of FGFR2 signaling | 19 | 1.35e-01 | 1.97e-01 | 0.3360 | 0.208000 | -0.011200 | 0.263000 | 0.013100 | 1.17e-01 | 9.33e-01 | 4.73e-02 | 9.21e-01 |
| SCF(Skp2)-mediated degradation of p27/p21 | 52 | 3.00e-04 | 1.19e-03 | 0.3350 | -0.118000 | 0.106000 | 0.292000 | 0.045400 | 1.42e-01 | 1.87e-01 | 2.73e-04 | 5.72e-01 |
| Vasopressin regulates renal water homeostasis via Aquaporins | 27 | 4.86e-02 | 8.89e-02 | 0.3340 | 0.233000 | -0.208000 | -0.119000 | 0.001650 | 3.64e-02 | 6.10e-02 | 2.86e-01 | 9.88e-01 |
| HSF1 activation | 22 | 4.15e-02 | 7.80e-02 | 0.3340 | -0.055600 | 0.179000 | 0.257000 | -0.102000 | 6.52e-01 | 1.46e-01 | 3.68e-02 | 4.09e-01 |
| Signaling by high-kinase activity BRAF mutants | 27 | 1.62e-01 | 2.31e-01 | 0.3340 | 0.180000 | -0.087800 | 0.234000 | 0.128000 | 1.05e-01 | 4.30e-01 | 3.51e-02 | 2.52e-01 |
| Regulation of expression of SLITs and ROBOs | 114 | 3.69e-12 | 8.10e-11 | 0.3340 | -0.153000 | 0.026000 | 0.291000 | -0.053300 | 4.86e-03 | 6.33e-01 | 8.98e-08 | 3.27e-01 |
| Mitochondrial iron-sulfur cluster biogenesis | 12 | 6.73e-01 | 7.36e-01 | 0.3340 | -0.189000 | -0.074500 | -0.151000 | -0.217000 | 2.57e-01 | 6.55e-01 | 3.64e-01 | 1.93e-01 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 29 | 3.94e-02 | 7.49e-02 | 0.3330 | 0.014000 | 0.261000 | 0.051000 | 0.200000 | 8.96e-01 | 1.51e-02 | 6.35e-01 | 6.25e-02 |
| Signaling by NTRK3 (TRKC) | 16 | 3.53e-01 | 4.40e-01 | 0.3330 | 0.179000 | -0.155000 | 0.027600 | 0.233000 | 2.15e-01 | 2.84e-01 | 8.49e-01 | 1.07e-01 |
| Repression of WNT target genes | 11 | 6.28e-01 | 6.98e-01 | 0.3330 | 0.223000 | 0.058500 | 0.215000 | 0.106000 | 2.00e-01 | 7.37e-01 | 2.17e-01 | 5.42e-01 |
| Separation of Sister Chromatids | 125 | 2.66e-08 | 2.74e-07 | 0.3320 | -0.176000 | 0.242000 | 0.145000 | 0.000534 | 7.28e-04 | 3.11e-06 | 5.17e-03 | 9.92e-01 |
| Nucleotide Excision Repair | 102 | 1.24e-06 | 9.35e-06 | 0.3320 | -0.205000 | 0.219000 | 0.094800 | -0.107000 | 3.61e-04 | 1.38e-04 | 9.90e-02 | 6.16e-02 |
| Nicotinamide salvaging | 12 | 4.03e-01 | 4.86e-01 | 0.3320 | 0.245000 | -0.069700 | -0.050900 | 0.206000 | 1.42e-01 | 6.76e-01 | 7.60e-01 | 2.16e-01 |
| Maturation of nucleoprotein | 10 | 6.61e-01 | 7.26e-01 | 0.3320 | 0.279000 | -0.005380 | 0.084500 | 0.158000 | 1.27e-01 | 9.77e-01 | 6.44e-01 | 3.86e-01 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 40 | 7.92e-04 | 2.77e-03 | 0.3310 | -0.230000 | 0.058100 | 0.225000 | -0.051900 | 1.18e-02 | 5.26e-01 | 1.38e-02 | 5.70e-01 |
| Negative regulation of FGFR3 signaling | 19 | 1.00e-01 | 1.58e-01 | 0.3310 | 0.158000 | 0.080000 | 0.278000 | -0.029400 | 2.34e-01 | 5.46e-01 | 3.60e-02 | 8.24e-01 |
| Cell Cycle Checkpoints | 191 | 3.42e-12 | 7.79e-11 | 0.3310 | -0.121000 | 0.219000 | 0.197000 | 0.088900 | 4.02e-03 | 1.98e-07 | 2.95e-06 | 3.50e-02 |
| Activation of NF-kappaB in B cells | 56 | 2.59e-05 | 1.35e-04 | 0.3310 | -0.212000 | 0.063000 | 0.243000 | -0.036400 | 6.06e-03 | 4.15e-01 | 1.69e-03 | 6.38e-01 |
| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | 46 | 5.10e-04 | 1.90e-03 | 0.3300 | -0.210000 | 0.104000 | 0.232000 | -0.017700 | 1.40e-02 | 2.23e-01 | 6.59e-03 | 8.35e-01 |
| Unfolded Protein Response (UPR) | 82 | 9.15e-05 | 4.24e-04 | 0.3280 | 0.044600 | 0.127000 | 0.291000 | 0.071000 | 4.86e-01 | 4.66e-02 | 5.44e-06 | 2.67e-01 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 76 | 2.88e-04 | 1.15e-03 | 0.3280 | -0.053600 | 0.195000 | 0.187000 | 0.178000 | 4.20e-01 | 3.37e-03 | 4.87e-03 | 7.34e-03 |
| Hh mutants abrogate ligand secretion | 47 | 5.84e-04 | 2.11e-03 | 0.3270 | -0.189000 | 0.113000 | 0.242000 | -0.007230 | 2.51e-02 | 1.81e-01 | 4.15e-03 | 9.32e-01 |
| RHO GTPases activate PKNs | 29 | 1.71e-01 | 2.42e-01 | 0.3270 | 0.101000 | -0.042000 | 0.251000 | 0.179000 | 3.45e-01 | 6.96e-01 | 1.96e-02 | 9.49e-02 |
| TICAM1, RIP1-mediated IKK complex recruitment | 14 | 2.11e-01 | 2.88e-01 | 0.3260 | -0.197000 | 0.112000 | 0.235000 | -0.008000 | 2.02e-01 | 4.69e-01 | 1.28e-01 | 9.59e-01 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 73 | 1.35e-04 | 6.00e-04 | 0.3260 | -0.218000 | 0.206000 | 0.091800 | -0.089600 | 1.31e-03 | 2.37e-03 | 1.76e-01 | 1.86e-01 |
| RAF activation | 34 | 7.36e-02 | 1.24e-01 | 0.3260 | -0.199000 | -0.015900 | -0.051900 | -0.252000 | 4.53e-02 | 8.72e-01 | 6.01e-01 | 1.09e-02 |
| Defective CFTR causes cystic fibrosis | 50 | 3.38e-04 | 1.33e-03 | 0.3250 | -0.220000 | 0.099500 | 0.217000 | 0.007070 | 7.14e-03 | 2.24e-01 | 8.00e-03 | 9.31e-01 |
| Signaling by Retinoic Acid | 29 | 1.66e-01 | 2.35e-01 | 0.3250 | -0.098900 | -0.176000 | -0.229000 | -0.110000 | 3.57e-01 | 1.00e-01 | 3.29e-02 | 3.06e-01 |
| Signaling by Receptor Tyrosine Kinases | 354 | 1.35e-12 | 3.31e-11 | 0.3240 | 0.195000 | -0.043600 | 0.159000 | 0.200000 | 4.01e-10 | 1.63e-01 | 3.63e-07 | 1.36e-10 |
| Signaling by NOTCH2 | 24 | 9.33e-02 | 1.48e-01 | 0.3240 | 0.279000 | -0.025700 | -0.048400 | 0.156000 | 1.81e-02 | 8.28e-01 | 6.82e-01 | 1.86e-01 |
| Negative regulation of NOTCH4 signaling | 47 | 1.89e-04 | 7.96e-04 | 0.3240 | -0.206000 | 0.039500 | 0.244000 | -0.039100 | 1.45e-02 | 6.40e-01 | 3.87e-03 | 6.43e-01 |
| Cytosolic sensors of pathogen-associated DNA | 52 | 1.04e-02 | 2.46e-02 | 0.3240 | 0.016300 | 0.191000 | 0.149000 | 0.215000 | 8.39e-01 | 1.74e-02 | 6.37e-02 | 7.46e-03 |
| G2/M DNA damage checkpoint | 49 | 1.28e-02 | 2.89e-02 | 0.3240 | -0.037600 | 0.212000 | 0.188000 | 0.152000 | 6.49e-01 | 1.02e-02 | 2.29e-02 | 6.64e-02 |
| Regulation of TNFR1 signaling | 26 | 7.62e-02 | 1.28e-01 | 0.3240 | 0.051200 | -0.242000 | 0.043800 | 0.204000 | 6.52e-01 | 3.25e-02 | 6.99e-01 | 7.23e-02 |
| SHC1 events in ERBB2 signaling | 15 | 4.91e-01 | 5.73e-01 | 0.3240 | 0.217000 | -0.162000 | 0.125000 | 0.126000 | 1.47e-01 | 2.78e-01 | 4.01e-01 | 3.97e-01 |
| Constitutive Signaling by AKT1 E17K in Cancer | 26 | 1.02e-01 | 1.60e-01 | 0.3230 | -0.228000 | -0.176000 | -0.046300 | -0.139000 | 4.45e-02 | 1.20e-01 | 6.83e-01 | 2.21e-01 |
| TRAF6 mediated IRF7 activation | 14 | 3.11e-01 | 3.94e-01 | 0.3230 | 0.049200 | 0.037000 | 0.065300 | 0.310000 | 7.50e-01 | 8.11e-01 | 6.72e-01 | 4.45e-02 |
| RNA Polymerase III Abortive And Retractive Initiation | 39 | 1.31e-02 | 2.93e-02 | 0.3230 | -0.253000 | 0.195000 | 0.049000 | -0.005440 | 6.39e-03 | 3.52e-02 | 5.97e-01 | 9.53e-01 |
| RNA Polymerase III Transcription | 39 | 1.31e-02 | 2.93e-02 | 0.3230 | -0.253000 | 0.195000 | 0.049000 | -0.005440 | 6.39e-03 | 3.52e-02 | 5.97e-01 | 9.53e-01 |
| Deadenylation-dependent mRNA decay | 53 | 4.33e-03 | 1.19e-02 | 0.3220 | -0.174000 | 0.248000 | 0.063100 | -0.089800 | 2.88e-02 | 1.79e-03 | 4.27e-01 | 2.59e-01 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | 52 | 1.83e-02 | 3.88e-02 | 0.3220 | 0.064200 | -0.053900 | 0.210000 | 0.230000 | 4.24e-01 | 5.02e-01 | 8.87e-03 | 4.23e-03 |
| Circadian Clock | 63 | 8.90e-03 | 2.14e-02 | 0.3220 | -0.217000 | -0.091800 | -0.097800 | -0.197000 | 2.94e-03 | 2.08e-01 | 1.80e-01 | 6.95e-03 |
| Myogenesis | 26 | 9.04e-02 | 1.46e-01 | 0.3220 | 0.088400 | -0.278000 | -0.066500 | 0.118000 | 4.36e-01 | 1.41e-02 | 5.57e-01 | 2.97e-01 |
| MHC class II antigen presentation | 71 | 3.89e-03 | 1.09e-02 | 0.3210 | 0.125000 | 0.090800 | 0.120000 | 0.255000 | 6.99e-02 | 1.87e-01 | 8.00e-02 | 2.10e-04 |
| Regulation of ornithine decarboxylase (ODC) | 44 | 8.21e-04 | 2.84e-03 | 0.3210 | -0.231000 | 0.067900 | 0.211000 | -0.016900 | 8.12e-03 | 4.36e-01 | 1.55e-02 | 8.46e-01 |
| RHO GTPases activate KTN1 | 10 | 7.20e-01 | 7.75e-01 | 0.3210 | 0.045700 | 0.107000 | 0.211000 | 0.212000 | 8.02e-01 | 5.59e-01 | 2.49e-01 | 2.46e-01 |
| Regulation of RUNX3 expression and activity | 47 | 4.07e-04 | 1.56e-03 | 0.3200 | -0.125000 | 0.104000 | 0.269000 | -0.060200 | 1.38e-01 | 2.19e-01 | 1.41e-03 | 4.76e-01 |
| Erythropoietin activates RAS | 11 | 5.44e-01 | 6.23e-01 | 0.3200 | 0.030000 | 0.037800 | 0.297000 | 0.109000 | 8.63e-01 | 8.28e-01 | 8.80e-02 | 5.32e-01 |
| GAB1 signalosome | 12 | 2.02e-01 | 2.78e-01 | 0.3200 | 0.024300 | -0.242000 | 0.160000 | -0.131000 | 8.84e-01 | 1.46e-01 | 3.38e-01 | 4.31e-01 |
| Mitotic Anaphase | 171 | 8.63e-11 | 1.39e-09 | 0.3200 | -0.143000 | 0.204000 | 0.194000 | 0.049900 | 1.27e-03 | 4.75e-06 | 1.31e-05 | 2.63e-01 |
| Mitotic Metaphase and Anaphase | 171 | 8.63e-11 | 1.39e-09 | 0.3200 | -0.143000 | 0.204000 | 0.194000 | 0.049900 | 1.27e-03 | 4.75e-06 | 1.31e-05 | 2.63e-01 |
| WNT5A-dependent internalization of FZD4 | 13 | 5.48e-01 | 6.27e-01 | 0.3200 | 0.134000 | -0.195000 | 0.121000 | 0.177000 | 4.04e-01 | 2.23e-01 | 4.51e-01 | 2.68e-01 |
| Macroautophagy | 98 | 8.71e-05 | 4.05e-04 | 0.3200 | -0.281000 | 0.076700 | -0.074600 | -0.108000 | 1.62e-06 | 1.91e-01 | 2.03e-01 | 6.42e-02 |
| Hedgehog ligand biogenesis | 50 | 4.79e-04 | 1.81e-03 | 0.3200 | -0.168000 | 0.095100 | 0.255000 | 0.013200 | 4.06e-02 | 2.45e-01 | 1.87e-03 | 8.72e-01 |
| Synthesis of very long-chain fatty acyl-CoAs | 10 | 7.23e-01 | 7.77e-01 | 0.3190 | 0.254000 | 0.003400 | 0.097500 | 0.167000 | 1.65e-01 | 9.85e-01 | 5.94e-01 | 3.60e-01 |
| TP53 Regulates Transcription of Cell Cycle Genes | 42 | 8.02e-02 | 1.32e-01 | 0.3190 | 0.084900 | 0.061500 | 0.252000 | 0.166000 | 3.41e-01 | 4.91e-01 | 4.80e-03 | 6.31e-02 |
| Positive epigenetic regulation of rRNA expression | 41 | 1.29e-02 | 2.90e-02 | 0.3190 | -0.053100 | 0.145000 | 0.273000 | 0.059300 | 5.57e-01 | 1.09e-01 | 2.51e-03 | 5.12e-01 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 44 | 1.04e-03 | 3.54e-03 | 0.3190 | -0.207000 | 0.094900 | 0.209000 | -0.078700 | 1.75e-02 | 2.77e-01 | 1.68e-02 | 3.67e-01 |
| Transcription of E2F targets under negative control by DREAM complex | 17 | 2.90e-01 | 3.73e-01 | 0.3190 | -0.123000 | 0.231000 | 0.160000 | 0.086700 | 3.81e-01 | 9.96e-02 | 2.54e-01 | 5.36e-01 |
| Membrane binding and targetting of GAG proteins | 10 | 2.21e-01 | 3.01e-01 | 0.3180 | -0.084600 | -0.032300 | 0.260000 | -0.159000 | 6.43e-01 | 8.60e-01 | 1.54e-01 | 3.84e-01 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 10 | 2.21e-01 | 3.01e-01 | 0.3180 | -0.084600 | -0.032300 | 0.260000 | -0.159000 | 6.43e-01 | 8.60e-01 | 1.54e-01 | 3.84e-01 |
| HSF1-dependent transactivation | 30 | 5.34e-03 | 1.41e-02 | 0.3180 | -0.155000 | 0.035900 | 0.256000 | -0.103000 | 1.42e-01 | 7.34e-01 | 1.55e-02 | 3.30e-01 |
| Degradation of beta-catenin by the destruction complex | 72 | 7.58e-06 | 4.68e-05 | 0.3180 | -0.205000 | 0.108000 | 0.203000 | -0.079300 | 2.64e-03 | 1.14e-01 | 3.00e-03 | 2.46e-01 |
| Cytosolic sulfonation of small molecules | 11 | 3.48e-01 | 4.35e-01 | 0.3180 | 0.288000 | 0.029900 | -0.101000 | 0.083600 | 9.83e-02 | 8.64e-01 | 5.62e-01 | 6.31e-01 |
| Detoxification of Reactive Oxygen Species | 26 | 7.93e-02 | 1.31e-01 | 0.3180 | 0.033000 | -0.291000 | 0.084000 | 0.091500 | 7.71e-01 | 1.04e-02 | 4.59e-01 | 4.20e-01 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 16 | 3.66e-01 | 4.51e-01 | 0.3170 | -0.216000 | -0.074100 | -0.024600 | -0.219000 | 1.35e-01 | 6.08e-01 | 8.65e-01 | 1.29e-01 |
| Synthesis of DNA | 106 | 6.65e-07 | 5.56e-06 | 0.3170 | -0.138000 | 0.147000 | 0.221000 | 0.106000 | 1.40e-02 | 9.19e-03 | 9.08e-05 | 5.98e-02 |
| DNA Replication | 111 | 7.14e-07 | 5.89e-06 | 0.3170 | -0.120000 | 0.153000 | 0.220000 | 0.119000 | 3.00e-02 | 5.34e-03 | 6.26e-05 | 3.08e-02 |
| Signaling by PDGFRA extracellular domain mutants | 11 | 5.20e-01 | 6.01e-01 | 0.3160 | -0.075200 | 0.099300 | 0.208000 | 0.202000 | 6.66e-01 | 5.69e-01 | 2.32e-01 | 2.45e-01 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 11 | 5.20e-01 | 6.01e-01 | 0.3160 | -0.075200 | 0.099300 | 0.208000 | 0.202000 | 6.66e-01 | 5.69e-01 | 2.32e-01 | 2.45e-01 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 40 | 5.56e-03 | 1.45e-02 | 0.3160 | -0.156000 | 0.170000 | 0.199000 | -0.084500 | 8.81e-02 | 6.36e-02 | 2.97e-02 | 3.55e-01 |
| Platelet sensitization by LDL | 13 | 2.78e-01 | 3.59e-01 | 0.3160 | -0.130000 | 0.119000 | 0.261000 | -0.027000 | 4.18e-01 | 4.59e-01 | 1.04e-01 | 8.66e-01 |
| Global Genome Nucleotide Excision Repair (GG-NER) | 78 | 2.47e-04 | 1.00e-03 | 0.3150 | -0.221000 | 0.194000 | 0.054900 | -0.101000 | 7.66e-04 | 3.17e-03 | 4.03e-01 | 1.24e-01 |
| FOXO-mediated transcription of cell cycle genes | 16 | 1.81e-01 | 2.54e-01 | 0.3150 | -0.028400 | -0.163000 | -0.000119 | -0.268000 | 8.44e-01 | 2.59e-01 | 9.99e-01 | 6.36e-02 |
| Homology Directed Repair | 82 | 2.21e-04 | 9.06e-04 | 0.3150 | -0.068000 | 0.186000 | 0.183000 | 0.162000 | 2.88e-01 | 3.61e-03 | 4.22e-03 | 1.12e-02 |
| SHC-mediated cascade:FGFR4 | 10 | 7.30e-01 | 7.80e-01 | 0.3140 | 0.156000 | -0.088400 | 0.101000 | 0.237000 | 3.93e-01 | 6.28e-01 | 5.80e-01 | 1.94e-01 |
| Degradation of GLI2 by the proteasome | 50 | 2.53e-04 | 1.02e-03 | 0.3140 | -0.231000 | 0.030500 | 0.186000 | -0.098700 | 4.84e-03 | 7.09e-01 | 2.33e-02 | 2.28e-01 |
| SHC-mediated cascade:FGFR3 | 10 | 7.57e-01 | 8.06e-01 | 0.3130 | 0.084600 | 0.082200 | 0.242000 | 0.161000 | 6.43e-01 | 6.53e-01 | 1.85e-01 | 3.80e-01 |
| IL-6-type cytokine receptor ligand interactions | 10 | 5.95e-01 | 6.71e-01 | 0.3120 | 0.121000 | -0.252000 | -0.122000 | -0.065700 | 5.08e-01 | 1.67e-01 | 5.05e-01 | 7.19e-01 |
| RNA Polymerase I Transcription Termination | 25 | 1.16e-01 | 1.77e-01 | 0.3110 | -0.051700 | 0.248000 | 0.175000 | -0.040800 | 6.55e-01 | 3.18e-02 | 1.29e-01 | 7.24e-01 |
| Signaling by VEGF | 83 | 4.23e-03 | 1.17e-02 | 0.3110 | 0.187000 | -0.120000 | 0.136000 | 0.169000 | 3.33e-03 | 5.95e-02 | 3.22e-02 | 7.78e-03 |
| Activation of BH3-only proteins | 24 | 3.76e-01 | 4.59e-01 | 0.3100 | 0.133000 | -0.063700 | 0.177000 | 0.208000 | 2.59e-01 | 5.89e-01 | 1.34e-01 | 7.77e-02 |
| TP53 Regulates Transcription of Cell Death Genes | 32 | 6.35e-02 | 1.09e-01 | 0.3100 | 0.278000 | -0.054900 | -0.019600 | 0.125000 | 6.55e-03 | 5.91e-01 | 8.48e-01 | 2.22e-01 |
| SLC-mediated transmembrane transport | 119 | 6.99e-06 | 4.40e-05 | 0.3100 | 0.140000 | -0.244000 | 0.020400 | 0.130000 | 8.43e-03 | 4.72e-06 | 7.02e-01 | 1.50e-02 |
| Purine ribonucleoside monophosphate biosynthesis | 12 | 5.76e-01 | 6.53e-01 | 0.3100 | -0.052400 | 0.024000 | -0.270000 | -0.140000 | 7.53e-01 | 8.85e-01 | 1.05e-01 | 4.00e-01 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 75 | 2.35e-05 | 1.23e-04 | 0.3100 | -0.111000 | 0.150000 | 0.245000 | -0.034900 | 9.72e-02 | 2.47e-02 | 2.53e-04 | 6.02e-01 |
| HCMV Infection | 68 | 5.69e-04 | 2.09e-03 | 0.3100 | -0.151000 | 0.240000 | 0.099800 | 0.076700 | 3.21e-02 | 6.43e-04 | 1.55e-01 | 2.75e-01 |
| Interleukin receptor SHC signaling | 15 | 5.59e-01 | 6.37e-01 | 0.3100 | 0.130000 | -0.043500 | 0.239000 | 0.141000 | 3.83e-01 | 7.70e-01 | 1.09e-01 | 3.46e-01 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | 59 | 2.35e-03 | 7.02e-03 | 0.3100 | -0.146000 | 0.239000 | 0.129000 | -0.028200 | 5.25e-02 | 1.53e-03 | 8.62e-02 | 7.08e-01 |
| Signaling by Interleukins | 275 | 8.52e-11 | 1.39e-09 | 0.3100 | 0.136000 | -0.053800 | 0.232000 | 0.143000 | 1.15e-04 | 1.27e-01 | 4.27e-11 | 5.00e-05 |
| Protein folding | 75 | 1.22e-02 | 2.78e-02 | 0.3100 | 0.147000 | 0.084500 | 0.215000 | 0.145000 | 2.84e-02 | 2.07e-01 | 1.34e-03 | 2.97e-02 |
| Selective autophagy | 51 | 3.93e-02 | 7.49e-02 | 0.3090 | -0.252000 | 0.033500 | -0.089500 | -0.151000 | 1.85e-03 | 6.80e-01 | 2.69e-01 | 6.16e-02 |
| Degradation of DVL | 48 | 3.67e-04 | 1.42e-03 | 0.3090 | -0.219000 | 0.016400 | 0.188000 | -0.110000 | 8.85e-03 | 8.44e-01 | 2.45e-02 | 1.86e-01 |
| G1/S Transition | 112 | 7.65e-07 | 6.22e-06 | 0.3080 | -0.122000 | 0.127000 | 0.228000 | 0.107000 | 2.62e-02 | 2.04e-02 | 3.09e-05 | 5.06e-02 |
| VEGFA-VEGFR2 Pathway | 77 | 6.26e-03 | 1.59e-02 | 0.3080 | 0.165000 | -0.128000 | 0.157000 | 0.162000 | 1.23e-02 | 5.33e-02 | 1.73e-02 | 1.40e-02 |
| Diseases of carbohydrate metabolism | 26 | 1.31e-01 | 1.93e-01 | 0.3080 | 0.005990 | -0.301000 | -0.055000 | -0.030400 | 9.58e-01 | 7.93e-03 | 6.27e-01 | 7.88e-01 |
| activated TAK1 mediates p38 MAPK activation | 17 | 2.22e-01 | 3.01e-01 | 0.3070 | -0.133000 | -0.170000 | 0.019500 | -0.217000 | 3.43e-01 | 2.25e-01 | 8.90e-01 | 1.22e-01 |
| trans-Golgi Network Vesicle Budding | 62 | 1.80e-02 | 3.82e-02 | 0.3060 | 0.043700 | 0.152000 | 0.183000 | 0.187000 | 5.52e-01 | 3.83e-02 | 1.26e-02 | 1.10e-02 |
| Senescence-Associated Secretory Phenotype (SASP) | 45 | 1.14e-01 | 1.75e-01 | 0.3060 | 0.133000 | 0.046400 | 0.222000 | 0.156000 | 1.24e-01 | 5.91e-01 | 9.89e-03 | 7.05e-02 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 53 | 2.56e-02 | 5.14e-02 | 0.3050 | -0.186000 | -0.089000 | -0.072000 | -0.213000 | 1.93e-02 | 2.63e-01 | 3.65e-01 | 7.30e-03 |
| GLI3 is processed to GLI3R by the proteasome | 50 | 6.13e-04 | 2.19e-03 | 0.3050 | -0.229000 | 0.049100 | 0.173000 | -0.091200 | 5.11e-03 | 5.49e-01 | 3.46e-02 | 2.65e-01 |
| Signaling by NTRKs | 111 | 1.60e-04 | 6.82e-04 | 0.3050 | 0.165000 | -0.086900 | 0.212000 | 0.115000 | 2.71e-03 | 1.15e-01 | 1.22e-04 | 3.75e-02 |
| Chaperonin-mediated protein folding | 69 | 1.79e-02 | 3.81e-02 | 0.3040 | 0.147000 | 0.106000 | 0.207000 | 0.128000 | 3.47e-02 | 1.27e-01 | 2.96e-03 | 6.64e-02 |
| Negative regulation of FGFR1 signaling | 19 | 1.34e-01 | 1.97e-01 | 0.3040 | 0.219000 | 0.027900 | 0.203000 | -0.045300 | 9.80e-02 | 8.33e-01 | 1.25e-01 | 7.33e-01 |
| G-protein beta:gamma signalling | 20 | 2.06e-01 | 2.83e-01 | 0.3030 | 0.193000 | -0.076100 | -0.054900 | 0.214000 | 1.35e-01 | 5.56e-01 | 6.71e-01 | 9.80e-02 |
| FCERI mediated Ca+2 mobilization | 18 | 3.07e-01 | 3.89e-01 | 0.3030 | 0.181000 | -0.223000 | -0.091600 | 0.031600 | 1.84e-01 | 1.02e-01 | 5.01e-01 | 8.17e-01 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | 23 | 2.27e-01 | 3.07e-01 | 0.3020 | -0.062600 | 0.155000 | 0.195000 | 0.159000 | 6.04e-01 | 1.97e-01 | 1.05e-01 | 1.87e-01 |
| Inactivation, recovery and regulation of the phototransduction cascade | 12 | 3.83e-01 | 4.65e-01 | 0.3020 | -0.111000 | -0.074100 | 0.026400 | -0.270000 | 5.07e-01 | 6.57e-01 | 8.74e-01 | 1.06e-01 |
| The phototransduction cascade | 12 | 3.83e-01 | 4.65e-01 | 0.3020 | -0.111000 | -0.074100 | 0.026400 | -0.270000 | 5.07e-01 | 6.57e-01 | 8.74e-01 | 1.06e-01 |
| Ovarian tumor domain proteases | 30 | 3.00e-01 | 3.83e-01 | 0.3020 | 0.092400 | 0.083500 | 0.192000 | 0.197000 | 3.81e-01 | 4.29e-01 | 6.92e-02 | 6.17e-02 |
| Cholesterol biosynthesis | 23 | 7.30e-02 | 1.23e-01 | 0.3020 | -0.025000 | -0.275000 | 0.107000 | -0.059000 | 8.36e-01 | 2.26e-02 | 3.75e-01 | 6.25e-01 |
| Transcriptional Regulation by E2F6 | 29 | 1.09e-01 | 1.69e-01 | 0.3010 | -0.077100 | 0.268000 | 0.101000 | -0.049900 | 4.73e-01 | 1.25e-02 | 3.47e-01 | 6.42e-01 |
| Fatty acyl-CoA biosynthesis | 18 | 1.74e-01 | 2.47e-01 | 0.3010 | 0.275000 | -0.061400 | 0.095800 | -0.041900 | 4.33e-02 | 6.52e-01 | 4.82e-01 | 7.59e-01 |
| Metabolism of water-soluble vitamins and cofactors | 89 | 1.12e-03 | 3.74e-03 | 0.2990 | -0.054400 | -0.021500 | -0.258000 | -0.140000 | 3.77e-01 | 7.26e-01 | 2.67e-05 | 2.30e-02 |
| DCC mediated attractive signaling | 13 | 5.90e-01 | 6.67e-01 | 0.2990 | 0.181000 | -0.156000 | 0.018200 | 0.179000 | 2.58e-01 | 3.30e-01 | 9.09e-01 | 2.65e-01 |
| RUNX2 regulates bone development | 26 | 1.30e-01 | 1.93e-01 | 0.2990 | 0.288000 | -0.018700 | 0.009920 | 0.075900 | 1.10e-02 | 8.69e-01 | 9.30e-01 | 5.03e-01 |
| Hyaluronan metabolism | 11 | 7.78e-01 | 8.22e-01 | 0.2990 | 0.150000 | -0.072600 | 0.152000 | 0.196000 | 3.90e-01 | 6.77e-01 | 3.82e-01 | 2.60e-01 |
| CD209 (DC-SIGN) signaling | 17 | 5.32e-01 | 6.13e-01 | 0.2990 | 0.153000 | -0.048200 | 0.089600 | 0.236000 | 2.75e-01 | 7.31e-01 | 5.23e-01 | 9.28e-02 |
| Switching of origins to a post-replicative state | 79 | 4.63e-05 | 2.26e-04 | 0.2990 | -0.181000 | 0.134000 | 0.194000 | 0.026200 | 5.52e-03 | 3.95e-02 | 2.87e-03 | 6.87e-01 |
| Signaling by SCF-KIT | 32 | 2.88e-01 | 3.71e-01 | 0.2990 | 0.196000 | -0.043600 | 0.128000 | 0.181000 | 5.58e-02 | 6.70e-01 | 2.09e-01 | 7.72e-02 |
| Apoptotic factor-mediated response | 13 | 6.27e-01 | 6.98e-01 | 0.2990 | 0.060500 | -0.014200 | 0.245000 | 0.159000 | 7.06e-01 | 9.30e-01 | 1.26e-01 | 3.21e-01 |
| G1/S-Specific Transcription | 21 | 1.50e-01 | 2.16e-01 | 0.2980 | -0.155000 | 0.138000 | 0.138000 | 0.164000 | 2.20e-01 | 2.74e-01 | 2.75e-01 | 1.93e-01 |
| Cell-cell junction organization | 22 | 3.71e-01 | 4.56e-01 | 0.2980 | 0.219000 | -0.139000 | 0.067500 | 0.130000 | 7.55e-02 | 2.58e-01 | 5.84e-01 | 2.92e-01 |
| Golgi Associated Vesicle Biogenesis | 48 | 3.74e-02 | 7.19e-02 | 0.2970 | -0.016700 | 0.204000 | 0.163000 | 0.141000 | 8.41e-01 | 1.46e-02 | 5.08e-02 | 9.14e-02 |
| Nucleobase biosynthesis | 15 | 5.56e-01 | 6.35e-01 | 0.2970 | -0.055700 | 0.031700 | -0.236000 | -0.168000 | 7.09e-01 | 8.32e-01 | 1.13e-01 | 2.59e-01 |
| SARS-CoV-2 Infection | 56 | 5.95e-02 | 1.05e-01 | 0.2970 | 0.090200 | 0.014200 | 0.188000 | 0.211000 | 2.44e-01 | 8.54e-01 | 1.52e-02 | 6.45e-03 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 15 | 4.54e-01 | 5.38e-01 | 0.2970 | -0.099500 | 0.255000 | 0.111000 | 0.026400 | 5.05e-01 | 8.76e-02 | 4.55e-01 | 8.60e-01 |
| Signaling by FGFR2 | 52 | 1.43e-02 | 3.13e-02 | 0.2970 | -0.004790 | 0.201000 | 0.215000 | 0.035100 | 9.52e-01 | 1.23e-02 | 7.31e-03 | 6.62e-01 |
| Arachidonic acid metabolism | 19 | 2.83e-01 | 3.65e-01 | 0.2960 | 0.229000 | -0.153000 | -0.074700 | 0.076700 | 8.43e-02 | 2.48e-01 | 5.73e-01 | 5.63e-01 |
| Assembly and cell surface presentation of NMDA receptors | 13 | 4.76e-01 | 5.57e-01 | 0.2950 | -0.056200 | -0.279000 | -0.027400 | -0.072300 | 7.26e-01 | 8.13e-02 | 8.64e-01 | 6.52e-01 |
| Phase I - Functionalization of compounds | 39 | 5.94e-02 | 1.05e-01 | 0.2950 | 0.050500 | -0.226000 | -0.126000 | -0.131000 | 5.86e-01 | 1.45e-02 | 1.74e-01 | 1.56e-01 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 11 | 5.64e-01 | 6.42e-01 | 0.2950 | -0.124000 | 0.189000 | 0.188000 | 0.024700 | 4.76e-01 | 2.78e-01 | 2.81e-01 | 8.87e-01 |
| Degradation of GLI1 by the proteasome | 51 | 1.34e-03 | 4.32e-03 | 0.2940 | -0.223000 | 0.062200 | 0.156000 | -0.092800 | 5.87e-03 | 4.43e-01 | 5.44e-02 | 2.52e-01 |
| Meiosis | 38 | 2.00e-02 | 4.18e-02 | 0.2940 | -0.030600 | 0.261000 | -0.009600 | 0.131000 | 7.45e-01 | 5.41e-03 | 9.19e-01 | 1.61e-01 |
| Apoptotic cleavage of cellular proteins | 27 | 3.01e-01 | 3.84e-01 | 0.2940 | 0.170000 | -0.126000 | 0.075900 | 0.189000 | 1.26e-01 | 2.58e-01 | 4.95e-01 | 8.94e-02 |
| Autophagy | 108 | 6.59e-05 | 3.17e-04 | 0.2930 | -0.272000 | 0.047500 | -0.043500 | -0.089800 | 1.14e-06 | 3.95e-01 | 4.36e-01 | 1.08e-01 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 62 | 5.84e-04 | 2.11e-03 | 0.2930 | -0.206000 | 0.121000 | 0.169000 | -0.020400 | 5.09e-03 | 1.01e-01 | 2.18e-02 | 7.82e-01 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 62 | 5.84e-04 | 2.11e-03 | 0.2930 | -0.206000 | 0.121000 | 0.169000 | -0.020400 | 5.09e-03 | 1.01e-01 | 2.18e-02 | 7.82e-01 |
| Cleavage of the damaged purine | 10 | 6.31e-01 | 6.98e-01 | 0.2930 | 0.265000 | 0.076200 | 0.033700 | 0.092500 | 1.47e-01 | 6.77e-01 | 8.54e-01 | 6.13e-01 |
| Depurination | 10 | 6.31e-01 | 6.98e-01 | 0.2930 | 0.265000 | 0.076200 | 0.033700 | 0.092500 | 1.47e-01 | 6.77e-01 | 8.54e-01 | 6.13e-01 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 10 | 6.31e-01 | 6.98e-01 | 0.2930 | 0.265000 | 0.076200 | 0.033700 | 0.092500 | 1.47e-01 | 6.77e-01 | 8.54e-01 | 6.13e-01 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 13 | 2.94e-01 | 3.76e-01 | 0.2920 | -0.243000 | -0.001910 | 0.159000 | -0.030700 | 1.29e-01 | 9.91e-01 | 3.22e-01 | 8.48e-01 |
| Signaling by FGFR | 60 | 1.52e-02 | 3.30e-02 | 0.2920 | 0.033700 | 0.187000 | 0.211000 | 0.070000 | 6.53e-01 | 1.26e-02 | 4.85e-03 | 3.49e-01 |
| Cargo concentration in the ER | 21 | 1.75e-01 | 2.48e-01 | 0.2920 | -0.182000 | 0.209000 | 0.019000 | 0.088500 | 1.49e-01 | 9.68e-02 | 8.80e-01 | 4.83e-01 |
| Role of phospholipids in phagocytosis | 14 | 4.11e-01 | 4.94e-01 | 0.2920 | 0.169000 | -0.165000 | -0.170000 | -0.026600 | 2.75e-01 | 2.87e-01 | 2.71e-01 | 8.63e-01 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | 28 | 3.09e-01 | 3.92e-01 | 0.2920 | 0.144000 | -0.078200 | 0.198000 | 0.138000 | 1.88e-01 | 4.74e-01 | 6.97e-02 | 2.07e-01 |
| Stabilization of p53 | 48 | 3.42e-03 | 9.77e-03 | 0.2920 | -0.177000 | 0.121000 | 0.180000 | -0.081400 | 3.41e-02 | 1.48e-01 | 3.12e-02 | 3.30e-01 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 38 | 1.49e-01 | 2.15e-01 | 0.2910 | 0.124000 | -0.133000 | 0.147000 | 0.174000 | 1.88e-01 | 1.55e-01 | 1.16e-01 | 6.42e-02 |
| Iron uptake and transport | 42 | 2.79e-02 | 5.55e-02 | 0.2910 | 0.059700 | -0.036800 | 0.065600 | 0.275000 | 5.03e-01 | 6.80e-01 | 4.62e-01 | 2.06e-03 |
| TCR signaling | 79 | 1.57e-05 | 8.77e-05 | 0.2900 | -0.156000 | 0.057300 | 0.238000 | 0.016600 | 1.67e-02 | 3.80e-01 | 2.68e-04 | 7.99e-01 |
| Insulin processing | 19 | 1.33e-01 | 1.96e-01 | 0.2900 | 0.027100 | 0.090700 | -0.022800 | 0.274000 | 8.38e-01 | 4.94e-01 | 8.64e-01 | 3.90e-02 |
| HDR through Homologous Recombination (HRR) | 49 | 2.57e-02 | 5.15e-02 | 0.2900 | -0.026200 | 0.171000 | 0.131000 | 0.193000 | 7.52e-01 | 3.91e-02 | 1.14e-01 | 1.97e-02 |
| Association of TriC/CCT with target proteins during biosynthesis | 36 | 8.77e-02 | 1.42e-01 | 0.2900 | -0.000577 | 0.211000 | 0.196000 | 0.032200 | 9.95e-01 | 2.87e-02 | 4.19e-02 | 7.38e-01 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 14 | 3.77e-01 | 4.60e-01 | 0.2890 | -0.210000 | 0.172000 | 0.054500 | 0.080900 | 1.74e-01 | 2.65e-01 | 7.24e-01 | 6.01e-01 |
| Regulation of TP53 Activity through Phosphorylation | 74 | 2.03e-03 | 6.15e-03 | 0.2880 | -0.024400 | 0.248000 | 0.144000 | 0.004880 | 7.17e-01 | 2.31e-04 | 3.24e-02 | 9.42e-01 |
| Cellular response to hypoxia | 62 | 5.30e-04 | 1.97e-03 | 0.2880 | -0.219000 | 0.034600 | 0.116000 | -0.142000 | 2.84e-03 | 6.38e-01 | 1.16e-01 | 5.42e-02 |
| Transcriptional regulation of pluripotent stem cells | 11 | 3.21e-01 | 4.04e-01 | 0.2870 | -0.090900 | -0.120000 | 0.242000 | -0.037700 | 6.02e-01 | 4.93e-01 | 1.65e-01 | 8.29e-01 |
| Mitotic Prometaphase | 137 | 1.05e-06 | 8.29e-06 | 0.2870 | -0.067600 | 0.243000 | 0.071500 | 0.118000 | 1.74e-01 | 1.03e-06 | 1.50e-01 | 1.77e-02 |
| Signaling by NTRK1 (TRKA) | 95 | 1.18e-03 | 3.89e-03 | 0.2860 | 0.145000 | -0.075200 | 0.214000 | 0.098500 | 1.47e-02 | 2.06e-01 | 3.30e-04 | 9.79e-02 |
| Regulation of PTEN stability and activity | 59 | 1.45e-03 | 4.64e-03 | 0.2850 | -0.214000 | 0.108000 | 0.143000 | -0.059800 | 4.50e-03 | 1.53e-01 | 5.81e-02 | 4.27e-01 |
| Estrogen-dependent gene expression | 75 | 1.31e-03 | 4.24e-03 | 0.2850 | -0.111000 | 0.227000 | 0.128000 | -0.034800 | 9.84e-02 | 6.86e-04 | 5.64e-02 | 6.03e-01 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 63 | 1.12e-03 | 3.74e-03 | 0.2850 | -0.193000 | 0.134000 | 0.158000 | -0.034600 | 8.20e-03 | 6.57e-02 | 3.07e-02 | 6.35e-01 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 63 | 1.12e-03 | 3.74e-03 | 0.2850 | -0.193000 | 0.134000 | 0.158000 | -0.034600 | 8.20e-03 | 6.57e-02 | 3.07e-02 | 6.35e-01 |
| Regulation of APC/C activators between G1/S and early anaphase | 67 | 4.44e-04 | 1.68e-03 | 0.2850 | -0.211000 | 0.109000 | 0.155000 | -0.024200 | 2.83e-03 | 1.25e-01 | 2.81e-02 | 7.33e-01 |
| Dopamine Neurotransmitter Release Cycle | 11 | 6.91e-01 | 7.51e-01 | 0.2830 | 0.012400 | -0.014800 | 0.178000 | 0.220000 | 9.43e-01 | 9.32e-01 | 3.08e-01 | 2.07e-01 |
| Negative regulation of FGFR4 signaling | 19 | 2.98e-01 | 3.81e-01 | 0.2830 | 0.195000 | -0.009840 | 0.204000 | 0.010900 | 1.40e-01 | 9.41e-01 | 1.24e-01 | 9.35e-01 |
| Infectious disease | 533 | 5.21e-18 | 2.91e-16 | 0.2820 | 0.046200 | 0.091700 | 0.231000 | 0.125000 | 7.20e-02 | 3.55e-04 | 2.03e-19 | 1.10e-06 |
| MAP2K and MAPK activation | 31 | 2.34e-01 | 3.13e-01 | 0.2820 | 0.168000 | -0.073600 | 0.193000 | 0.093000 | 1.07e-01 | 4.78e-01 | 6.35e-02 | 3.70e-01 |
| PI-3K cascade:FGFR1 | 10 | 6.14e-01 | 6.91e-01 | 0.2810 | -0.098100 | -0.033300 | -0.008620 | -0.261000 | 5.91e-01 | 8.55e-01 | 9.62e-01 | 1.53e-01 |
| Transcriptional Regulation by MECP2 | 42 | 6.77e-02 | 1.15e-01 | 0.2810 | -0.115000 | -0.151000 | -0.203000 | -0.037100 | 1.98e-01 | 9.00e-02 | 2.27e-02 | 6.78e-01 |
| RNA Polymerase III Transcription Termination | 22 | 2.55e-01 | 3.37e-01 | 0.2800 | -0.229000 | 0.155000 | 0.040100 | -0.022300 | 6.27e-02 | 2.09e-01 | 7.45e-01 | 8.56e-01 |
| Signaling by Rho GTPases | 268 | 5.15e-07 | 4.39e-06 | 0.2800 | 0.125000 | 0.000868 | 0.179000 | 0.175000 | 4.48e-04 | 9.81e-01 | 5.02e-07 | 9.28e-07 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 58 | 1.24e-03 | 4.04e-03 | 0.2800 | -0.206000 | 0.082300 | 0.165000 | -0.046600 | 6.81e-03 | 2.79e-01 | 3.03e-02 | 5.40e-01 |
| Signaling by FGFR2 in disease | 28 | 1.13e-01 | 1.74e-01 | 0.2800 | -0.124000 | 0.124000 | 0.213000 | 0.047600 | 2.55e-01 | 2.57e-01 | 5.14e-02 | 6.63e-01 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 10 | 4.40e-01 | 5.24e-01 | 0.2800 | -0.036400 | 0.042000 | -0.270000 | 0.048500 | 8.42e-01 | 8.18e-01 | 1.40e-01 | 7.91e-01 |
| Interleukin-15 signaling | 11 | 4.73e-01 | 5.55e-01 | 0.2790 | 0.024900 | -0.247000 | 0.115000 | -0.058100 | 8.86e-01 | 1.57e-01 | 5.10e-01 | 7.39e-01 |
| APC/C:Cdc20 mediated degradation of Securin | 59 | 2.50e-03 | 7.39e-03 | 0.2790 | -0.209000 | 0.108000 | 0.127000 | -0.079600 | 5.45e-03 | 1.53e-01 | 9.25e-02 | 2.91e-01 |
| G1/S DNA Damage Checkpoints | 57 | 1.79e-03 | 5.50e-03 | 0.2780 | -0.140000 | 0.105000 | 0.216000 | -0.019500 | 6.89e-02 | 1.72e-01 | 4.85e-03 | 8.00e-01 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 55 | 1.34e-03 | 4.32e-03 | 0.2780 | -0.202000 | 0.031700 | 0.143000 | -0.123000 | 9.79e-03 | 6.85e-01 | 6.75e-02 | 1.16e-01 |
| Antigen processing-Cross presentation | 69 | 8.57e-03 | 2.09e-02 | 0.2770 | -0.010800 | 0.048700 | 0.233000 | 0.140000 | 8.77e-01 | 4.85e-01 | 8.27e-04 | 4.42e-02 |
| Mitotic G1 phase and G1/S transition | 127 | 9.20e-06 | 5.49e-05 | 0.2760 | -0.073600 | 0.100000 | 0.219000 | 0.114000 | 1.53e-01 | 5.21e-02 | 2.14e-05 | 2.73e-02 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | 22 | 1.78e-01 | 2.50e-01 | 0.2760 | -0.036800 | -0.089000 | 0.242000 | 0.090600 | 7.65e-01 | 4.70e-01 | 4.93e-02 | 4.62e-01 |
| Metabolism of polyamines | 50 | 4.87e-03 | 1.31e-02 | 0.2760 | -0.173000 | 0.089900 | 0.196000 | 0.002780 | 3.49e-02 | 2.72e-01 | 1.68e-02 | 9.73e-01 |
| Removal of the Flap Intermediate from the C-strand | 17 | 6.29e-01 | 6.98e-01 | 0.2760 | 0.090900 | 0.138000 | 0.129000 | 0.179000 | 5.17e-01 | 3.24e-01 | 3.56e-01 | 2.02e-01 |
| Neddylation | 199 | 8.69e-08 | 8.61e-07 | 0.2750 | -0.234000 | -0.003930 | -0.018400 | -0.144000 | 1.42e-08 | 9.24e-01 | 6.57e-01 | 4.94e-04 |
| CDK-mediated phosphorylation and removal of Cdc6 | 63 | 1.62e-03 | 5.06e-03 | 0.2750 | -0.172000 | 0.125000 | 0.174000 | -0.016400 | 1.84e-02 | 8.64e-02 | 1.69e-02 | 8.22e-01 |
| Signaling by cytosolic FGFR1 fusion mutants | 17 | 6.76e-01 | 7.38e-01 | 0.2750 | -0.128000 | -0.003090 | -0.127000 | -0.208000 | 3.61e-01 | 9.82e-01 | 3.67e-01 | 1.37e-01 |
| Ras activation upon Ca2+ influx through NMDA receptor | 13 | 6.34e-01 | 7.00e-01 | 0.2750 | 0.039500 | -0.208000 | -0.128000 | -0.120000 | 8.05e-01 | 1.94e-01 | 4.24e-01 | 4.54e-01 |
| ER-Phagosome pathway | 61 | 4.81e-03 | 1.30e-02 | 0.2720 | -0.074500 | 0.063700 | 0.239000 | 0.087000 | 3.15e-01 | 3.90e-01 | 1.28e-03 | 2.41e-01 |
| COPI-dependent Golgi-to-ER retrograde traffic | 62 | 6.19e-02 | 1.07e-01 | 0.2720 | 0.136000 | 0.137000 | 0.148000 | 0.121000 | 6.36e-02 | 6.23e-02 | 4.37e-02 | 9.91e-02 |
| Negative regulation of the PI3K/AKT network | 69 | 3.74e-02 | 7.19e-02 | 0.2720 | 0.192000 | 0.015300 | 0.163000 | 0.101000 | 5.82e-03 | 8.27e-01 | 1.94e-02 | 1.47e-01 |
| UCH proteinases | 74 | 1.52e-04 | 6.58e-04 | 0.2720 | -0.182000 | 0.071900 | 0.180000 | -0.053300 | 6.77e-03 | 2.86e-01 | 7.38e-03 | 4.29e-01 |
| Nicotinate metabolism | 20 | 2.67e-01 | 3.48e-01 | 0.2710 | 0.138000 | -0.128000 | -0.195000 | -0.012500 | 2.84e-01 | 3.22e-01 | 1.32e-01 | 9.23e-01 |
| Nervous system development | 392 | 1.70e-12 | 4.09e-11 | 0.2710 | 0.127000 | -0.116000 | 0.170000 | 0.123000 | 1.90e-05 | 9.98e-05 | 1.03e-08 | 3.44e-05 |
| Metabolism of folate and pterines | 13 | 5.89e-01 | 6.66e-01 | 0.2710 | -0.017300 | -0.264000 | -0.043100 | -0.037900 | 9.14e-01 | 9.89e-02 | 7.88e-01 | 8.13e-01 |
| Rho GTPase cycle | 103 | 5.19e-03 | 1.37e-02 | 0.2710 | 0.173000 | -0.107000 | 0.087200 | 0.156000 | 2.49e-03 | 6.10e-02 | 1.27e-01 | 6.21e-03 |
| Dual Incision in GG-NER | 38 | 5.85e-02 | 1.03e-01 | 0.2710 | -0.212000 | 0.159000 | 0.055900 | 0.014900 | 2.42e-02 | 8.99e-02 | 5.51e-01 | 8.74e-01 |
| SARS-CoV Infections | 121 | 2.74e-03 | 7.98e-03 | 0.2700 | 0.084600 | -0.001650 | 0.185000 | 0.178000 | 1.09e-01 | 9.75e-01 | 4.65e-04 | 7.34e-04 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 63 | 2.25e-03 | 6.72e-03 | 0.2700 | -0.191000 | 0.117000 | 0.149000 | -0.023300 | 8.82e-03 | 1.07e-01 | 4.15e-02 | 7.49e-01 |
| FOXO-mediated transcription | 51 | 1.05e-01 | 1.64e-01 | 0.2700 | -0.117000 | -0.121000 | -0.103000 | -0.184000 | 1.49e-01 | 1.36e-01 | 2.02e-01 | 2.31e-02 |
| Neurotransmitter release cycle | 22 | 3.64e-01 | 4.49e-01 | 0.2700 | 0.011300 | 0.005490 | 0.242000 | 0.119000 | 9.27e-01 | 9.64e-01 | 5.00e-02 | 3.33e-01 |
| DNA Double-Strand Break Repair | 109 | 1.52e-04 | 6.58e-04 | 0.2690 | -0.071200 | 0.183000 | 0.120000 | 0.139000 | 2.00e-01 | 9.72e-04 | 3.04e-02 | 1.21e-02 |
| p53-Dependent G1 DNA Damage Response | 56 | 2.68e-03 | 7.83e-03 | 0.2690 | -0.137000 | 0.091900 | 0.212000 | -0.023900 | 7.71e-02 | 2.35e-01 | 6.17e-03 | 7.57e-01 |
| p53-Dependent G1/S DNA damage checkpoint | 56 | 2.68e-03 | 7.83e-03 | 0.2690 | -0.137000 | 0.091900 | 0.212000 | -0.023900 | 7.71e-02 | 2.35e-01 | 6.17e-03 | 7.57e-01 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 62 | 5.18e-02 | 9.34e-02 | 0.2690 | 0.194000 | -0.004790 | 0.163000 | 0.091400 | 8.50e-03 | 9.48e-01 | 2.63e-02 | 2.14e-01 |
| S Phase | 144 | 1.03e-06 | 8.24e-06 | 0.2690 | -0.132000 | 0.143000 | 0.170000 | 0.072700 | 6.42e-03 | 3.11e-03 | 4.47e-04 | 1.33e-01 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 31 | 3.35e-01 | 4.21e-01 | 0.2690 | 0.033300 | 0.108000 | 0.180000 | 0.164000 | 7.49e-01 | 2.98e-01 | 8.23e-02 | 1.15e-01 |
| Constitutive Signaling by Aberrant PI3K in Cancer | 38 | 1.16e-01 | 1.77e-01 | 0.2680 | 0.223000 | -0.122000 | 0.074600 | 0.044600 | 1.75e-02 | 1.95e-01 | 4.26e-01 | 6.35e-01 |
| Endogenous sterols | 13 | 8.15e-01 | 8.52e-01 | 0.2680 | -0.116000 | -0.053800 | -0.159000 | -0.174000 | 4.70e-01 | 7.37e-01 | 3.21e-01 | 2.78e-01 |
| Downregulation of TGF-beta receptor signaling | 24 | 1.27e-01 | 1.90e-01 | 0.2680 | -0.120000 | 0.116000 | 0.164000 | -0.130000 | 3.08e-01 | 3.27e-01 | 1.64e-01 | 2.71e-01 |
| APC/C-mediated degradation of cell cycle proteins | 72 | 1.28e-03 | 4.15e-03 | 0.2680 | -0.180000 | 0.135000 | 0.146000 | -0.005610 | 8.49e-03 | 4.82e-02 | 3.29e-02 | 9.35e-01 |
| Regulation of mitotic cell cycle | 72 | 1.28e-03 | 4.15e-03 | 0.2680 | -0.180000 | 0.135000 | 0.146000 | -0.005610 | 8.49e-03 | 4.82e-02 | 3.29e-02 | 9.35e-01 |
| Vitamin B5 (pantothenate) metabolism | 15 | 3.92e-01 | 4.74e-01 | 0.2670 | 0.013100 | 0.120000 | -0.228000 | -0.069500 | 9.30e-01 | 4.20e-01 | 1.26e-01 | 6.41e-01 |
| TNFR1-induced NFkappaB signaling pathway | 21 | 2.57e-01 | 3.38e-01 | 0.2670 | -0.005190 | -0.232000 | -0.030400 | 0.129000 | 9.67e-01 | 6.55e-02 | 8.09e-01 | 3.08e-01 |
| Activation of the AP-1 family of transcription factors | 10 | 3.63e-01 | 4.49e-01 | 0.2670 | 0.097100 | -0.007010 | 0.182000 | -0.169000 | 5.95e-01 | 9.69e-01 | 3.19e-01 | 3.54e-01 |
| Formation of the beta-catenin:TCF transactivating complex | 28 | 3.98e-01 | 4.81e-01 | 0.2660 | 0.054000 | 0.159000 | 0.151000 | 0.141000 | 6.21e-01 | 1.46e-01 | 1.67e-01 | 1.95e-01 |
| Neurotransmitter receptors and postsynaptic signal transmission | 95 | 1.48e-03 | 4.72e-03 | 0.2660 | 0.166000 | -0.195000 | -0.015100 | 0.071800 | 5.28e-03 | 1.07e-03 | 7.99e-01 | 2.27e-01 |
| M Phase | 275 | 2.13e-11 | 3.80e-10 | 0.2660 | -0.112000 | 0.196000 | 0.120000 | 0.074900 | 1.57e-03 | 2.81e-08 | 6.89e-04 | 3.36e-02 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 15 | 6.58e-01 | 7.24e-01 | 0.2660 | 0.201000 | 0.092500 | 0.113000 | 0.094000 | 1.77e-01 | 5.35e-01 | 4.51e-01 | 5.28e-01 |
| MicroRNA (miRNA) biogenesis | 22 | 2.39e-01 | 3.19e-01 | 0.2660 | -0.203000 | 0.161000 | -0.038500 | 0.042100 | 9.87e-02 | 1.91e-01 | 7.55e-01 | 7.32e-01 |
| Interleukin-1 family signaling | 102 | 8.41e-06 | 5.11e-05 | 0.2660 | -0.071400 | 0.040300 | 0.252000 | 0.014100 | 2.14e-01 | 4.84e-01 | 1.13e-05 | 8.06e-01 |
| Intraflagellar transport | 35 | 2.37e-02 | 4.81e-02 | 0.2640 | 0.156000 | 0.122000 | -0.107000 | 0.139000 | 1.11e-01 | 2.12e-01 | 2.74e-01 | 1.56e-01 |
| Metabolism of nitric oxide: NOS3 activation and regulation | 13 | 4.71e-01 | 5.55e-01 | 0.2640 | -0.060000 | -0.141000 | 0.178000 | 0.120000 | 7.08e-01 | 3.79e-01 | 2.66e-01 | 4.55e-01 |
| Signaling by Hippo | 18 | 6.38e-01 | 7.04e-01 | 0.2630 | 0.041400 | 0.106000 | 0.196000 | 0.134000 | 7.61e-01 | 4.35e-01 | 1.51e-01 | 3.23e-01 |
| AKT phosphorylates targets in the cytosol | 14 | 3.20e-01 | 4.04e-01 | 0.2630 | -0.181000 | -0.147000 | 0.108000 | 0.059300 | 2.42e-01 | 3.40e-01 | 4.86e-01 | 7.01e-01 |
| Neuronal System | 172 | 2.26e-06 | 1.60e-05 | 0.2630 | 0.143000 | -0.217000 | 0.009390 | 0.044800 | 1.30e-03 | 1.06e-06 | 8.32e-01 | 3.13e-01 |
| Downstream signaling events of B Cell Receptor (BCR) | 67 | 2.22e-04 | 9.06e-04 | 0.2630 | -0.185000 | -0.008680 | 0.180000 | -0.048100 | 8.83e-03 | 9.02e-01 | 1.09e-02 | 4.97e-01 |
| FCERI mediated MAPK activation | 23 | 4.49e-01 | 5.33e-01 | 0.2630 | 0.150000 | -0.005480 | 0.048400 | 0.210000 | 2.14e-01 | 9.64e-01 | 6.88e-01 | 8.07e-02 |
| Cytokine Signaling in Immune system | 514 | 1.88e-13 | 5.02e-12 | 0.2620 | 0.139000 | -0.025100 | 0.188000 | 0.115000 | 9.11e-08 | 3.36e-01 | 5.43e-13 | 1.01e-05 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 55 | 4.29e-03 | 1.18e-02 | 0.2620 | -0.146000 | 0.094800 | 0.190000 | -0.049900 | 6.21e-02 | 2.25e-01 | 1.52e-02 | 5.23e-01 |
| Cell Cycle, Mitotic | 397 | 1.30e-14 | 4.10e-13 | 0.2620 | -0.067500 | 0.183000 | 0.145000 | 0.098000 | 2.23e-02 | 5.60e-10 | 9.85e-07 | 9.02e-04 |
| Chromatin modifying enzymes | 179 | 4.83e-07 | 4.16e-06 | 0.2620 | -0.193000 | 0.138000 | 0.053000 | -0.096000 | 8.99e-06 | 1.49e-03 | 2.23e-01 | 2.75e-02 |
| Chromatin organization | 179 | 4.83e-07 | 4.16e-06 | 0.2620 | -0.193000 | 0.138000 | 0.053000 | -0.096000 | 8.99e-06 | 1.49e-03 | 2.23e-01 | 2.75e-02 |
| Synthesis of IP2, IP, and Ins in the cytosol | 12 | 5.14e-01 | 5.95e-01 | 0.2610 | -0.112000 | -0.032500 | 0.186000 | 0.141000 | 5.00e-01 | 8.46e-01 | 2.66e-01 | 3.98e-01 |
| SHC-mediated cascade:FGFR1 | 10 | 8.62e-01 | 8.91e-01 | 0.2600 | 0.201000 | -0.016800 | 0.100000 | 0.130000 | 2.70e-01 | 9.27e-01 | 5.84e-01 | 4.75e-01 |
| Interleukin-1 signaling | 84 | 4.01e-05 | 1.99e-04 | 0.2600 | -0.118000 | 0.036900 | 0.227000 | -0.027700 | 6.13e-02 | 5.59e-01 | 3.26e-04 | 6.61e-01 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 66 | 7.60e-02 | 1.27e-01 | 0.2600 | 0.196000 | -0.037400 | 0.116000 | 0.120000 | 5.99e-03 | 6.00e-01 | 1.05e-01 | 9.12e-02 |
| Reproduction | 44 | 3.17e-02 | 6.22e-02 | 0.2590 | 0.019600 | 0.213000 | -0.004110 | 0.147000 | 8.22e-01 | 1.48e-02 | 9.62e-01 | 9.16e-02 |
| Cell Cycle | 484 | 1.92e-17 | 9.43e-16 | 0.2590 | -0.069700 | 0.193000 | 0.134000 | 0.084200 | 9.45e-03 | 6.31e-13 | 6.21e-07 | 1.73e-03 |
| Signaling by RAF1 mutants | 32 | 1.45e-01 | 2.09e-01 | 0.2590 | 0.147000 | -0.175000 | 0.121000 | 0.010600 | 1.50e-01 | 8.67e-02 | 2.38e-01 | 9.17e-01 |
| Cytochrome P450 - arranged by substrate type | 18 | 5.57e-01 | 6.36e-01 | 0.2590 | 0.020800 | -0.190000 | -0.159000 | -0.069800 | 8.78e-01 | 1.62e-01 | 2.42e-01 | 6.08e-01 |
| Meiotic synapsis | 22 | 3.05e-01 | 3.88e-01 | 0.2580 | -0.032200 | 0.226000 | 0.019900 | 0.119000 | 7.94e-01 | 6.72e-02 | 8.72e-01 | 3.34e-01 |
| Regulation of RAS by GAPs | 57 | 6.03e-03 | 1.55e-02 | 0.2560 | -0.139000 | 0.089100 | 0.196000 | 0.004400 | 7.00e-02 | 2.45e-01 | 1.05e-02 | 9.54e-01 |
| Tie2 Signaling | 13 | 5.13e-01 | 5.95e-01 | 0.2560 | -0.164000 | 0.159000 | 0.036400 | 0.110000 | 3.06e-01 | 3.21e-01 | 8.20e-01 | 4.92e-01 |
| Signaling by NOTCH3 | 38 | 2.18e-01 | 2.98e-01 | 0.2560 | 0.185000 | -0.115000 | 0.023200 | 0.132000 | 4.86e-02 | 2.20e-01 | 8.04e-01 | 1.58e-01 |
| Trafficking of GluR2-containing AMPA receptors | 10 | 6.62e-01 | 7.27e-01 | 0.2560 | 0.000931 | -0.162000 | 0.184000 | 0.072500 | 9.96e-01 | 3.75e-01 | 3.14e-01 | 6.91e-01 |
| Signaling by ROBO receptors | 151 | 2.05e-09 | 2.65e-08 | 0.2550 | -0.084100 | -0.020900 | 0.240000 | -0.016200 | 7.57e-02 | 6.59e-01 | 4.09e-07 | 7.32e-01 |
| SUMOylation | 137 | 4.25e-05 | 2.08e-04 | 0.2550 | -0.127000 | 0.203000 | 0.086500 | -0.011500 | 1.02e-02 | 4.25e-05 | 8.15e-02 | 8.17e-01 |
| eNOS activation | 10 | 7.07e-01 | 7.65e-01 | 0.2550 | 0.062300 | -0.182000 | 0.159000 | 0.051600 | 7.33e-01 | 3.18e-01 | 3.84e-01 | 7.78e-01 |
| PPARA activates gene expression | 101 | 6.55e-03 | 1.66e-02 | 0.2550 | -0.204000 | 0.087700 | -0.055500 | -0.112000 | 4.18e-04 | 1.29e-01 | 3.37e-01 | 5.16e-02 |
| Immune System | 1219 | 4.56e-25 | 5.09e-23 | 0.2550 | 0.128000 | -0.022900 | 0.133000 | 0.174000 | 3.20e-13 | 1.92e-01 | 4.49e-14 | 3.03e-23 |
| Axon guidance | 375 | 2.09e-10 | 3.21e-09 | 0.2540 | 0.124000 | -0.101000 | 0.163000 | 0.112000 | 4.45e-05 | 8.27e-04 | 7.98e-08 | 2.27e-04 |
| TGF-beta receptor signaling activates SMADs | 29 | 8.49e-02 | 1.38e-01 | 0.2540 | -0.109000 | 0.095500 | 0.179000 | -0.108000 | 3.12e-01 | 3.74e-01 | 9.58e-02 | 3.13e-01 |
| Regulation of TP53 Activity | 134 | 8.50e-05 | 3.97e-04 | 0.2540 | -0.052600 | 0.229000 | 0.094700 | -0.010100 | 2.94e-01 | 4.92e-06 | 5.92e-02 | 8.40e-01 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 14 | 4.57e-01 | 5.42e-01 | 0.2540 | -0.083000 | 0.047800 | 0.086600 | 0.218000 | 5.91e-01 | 7.57e-01 | 5.75e-01 | 1.58e-01 |
| Mismatch Repair | 14 | 4.58e-01 | 5.42e-01 | 0.2530 | -0.160000 | 0.170000 | -0.031200 | 0.094600 | 3.01e-01 | 2.72e-01 | 8.40e-01 | 5.40e-01 |
| ER Quality Control Compartment (ERQC) | 18 | 6.30e-01 | 6.98e-01 | 0.2530 | 0.003950 | 0.101000 | 0.182000 | 0.143000 | 9.77e-01 | 4.58e-01 | 1.80e-01 | 2.95e-01 |
| Tight junction interactions | 10 | 4.29e-01 | 5.12e-01 | 0.2520 | 0.138000 | -0.011700 | 0.076700 | -0.197000 | 4.51e-01 | 9.49e-01 | 6.74e-01 | 2.81e-01 |
| Kinesins | 24 | 2.47e-01 | 3.28e-01 | 0.2520 | 0.225000 | 0.077700 | -0.022900 | 0.080700 | 5.66e-02 | 5.10e-01 | 8.46e-01 | 4.94e-01 |
| Potential therapeutics for SARS | 66 | 8.06e-02 | 1.33e-01 | 0.2520 | 0.081800 | -0.026300 | 0.189000 | 0.143000 | 2.52e-01 | 7.12e-01 | 7.93e-03 | 4.53e-02 |
| RAB geranylgeranylation | 41 | 7.92e-02 | 1.31e-01 | 0.2510 | 0.126000 | 0.206000 | 0.021900 | 0.066900 | 1.63e-01 | 2.27e-02 | 8.08e-01 | 4.59e-01 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 19 | 6.00e-01 | 6.76e-01 | 0.2510 | 0.204000 | -0.004710 | 0.040200 | 0.141000 | 1.23e-01 | 9.72e-01 | 7.61e-01 | 2.89e-01 |
| TNFR2 non-canonical NF-kB pathway | 63 | 3.48e-03 | 9.88e-03 | 0.2510 | -0.063900 | -0.024100 | 0.234000 | 0.059900 | 3.81e-01 | 7.42e-01 | 1.34e-03 | 4.12e-01 |
| Cell death signalling via NRAGE, NRIF and NADE | 57 | 5.32e-02 | 9.54e-02 | 0.2510 | 0.130000 | -0.199000 | -0.005470 | 0.081300 | 9.11e-02 | 9.49e-03 | 9.43e-01 | 2.89e-01 |
| Inositol phosphate metabolism | 38 | 1.44e-01 | 2.08e-01 | 0.2510 | 0.108000 | -0.216000 | -0.060900 | -0.029800 | 2.49e-01 | 2.15e-02 | 5.16e-01 | 7.51e-01 |
| p75 NTR receptor-mediated signalling | 73 | 3.56e-02 | 6.91e-02 | 0.2510 | 0.149000 | -0.155000 | 0.053600 | 0.117000 | 2.79e-02 | 2.27e-02 | 4.29e-01 | 8.32e-02 |
| Termination of translesion DNA synthesis | 28 | 3.43e-01 | 4.29e-01 | 0.2500 | -0.028400 | 0.092300 | 0.170000 | 0.157000 | 7.95e-01 | 3.98e-01 | 1.21e-01 | 1.51e-01 |
| Oncogene Induced Senescence | 29 | 2.26e-01 | 3.06e-01 | 0.2500 | 0.210000 | 0.113000 | 0.058600 | 0.048200 | 5.05e-02 | 2.91e-01 | 5.85e-01 | 6.53e-01 |
| COPII-mediated vesicle transport | 56 | 2.82e-02 | 5.58e-02 | 0.2500 | -0.156000 | 0.181000 | 0.066300 | 0.032200 | 4.32e-02 | 1.94e-02 | 3.91e-01 | 6.78e-01 |
| Signaling by ERBB2 TMD/JMD mutants | 14 | 7.72e-01 | 8.19e-01 | 0.2500 | 0.118000 | -0.106000 | 0.096700 | 0.168000 | 4.46e-01 | 4.94e-01 | 5.31e-01 | 2.77e-01 |
| Cyclin A:Cdk2-associated events at S phase entry | 77 | 1.92e-03 | 5.88e-03 | 0.2500 | -0.097100 | 0.094800 | 0.208000 | 0.029800 | 1.41e-01 | 1.51e-01 | 1.66e-03 | 6.52e-01 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | 19 | 4.81e-01 | 5.62e-01 | 0.2500 | -0.176000 | 0.172000 | -0.042700 | -0.012100 | 1.85e-01 | 1.95e-01 | 7.47e-01 | 9.28e-01 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 19 | 4.81e-01 | 5.62e-01 | 0.2500 | -0.176000 | 0.172000 | -0.042700 | -0.012100 | 1.85e-01 | 1.95e-01 | 7.47e-01 | 9.28e-01 |
| Fanconi Anemia Pathway | 24 | 3.73e-01 | 4.58e-01 | 0.2490 | -0.165000 | 0.176000 | 0.050900 | -0.037600 | 1.62e-01 | 1.37e-01 | 6.66e-01 | 7.50e-01 |
| Antigen processing: Ubiquitination & Proteasome degradation | 264 | 6.59e-09 | 7.86e-08 | 0.2490 | -0.223000 | 0.019000 | -0.004210 | -0.109000 | 5.80e-10 | 5.98e-01 | 9.07e-01 | 2.42e-03 |
| CLEC7A (Dectin-1) signaling | 80 | 8.44e-05 | 3.96e-04 | 0.2490 | -0.166000 | -0.017900 | 0.174000 | -0.063300 | 1.06e-02 | 7.83e-01 | 7.37e-03 | 3.29e-01 |
| Opioid Signalling | 64 | 2.37e-02 | 4.81e-02 | 0.2480 | 0.119000 | -0.200000 | -0.087800 | 0.004290 | 1.01e-01 | 5.80e-03 | 2.25e-01 | 9.53e-01 |
| Regulation of lipid metabolism by PPARalpha | 103 | 7.56e-03 | 1.87e-02 | 0.2480 | -0.195000 | 0.095200 | -0.048700 | -0.109000 | 6.34e-04 | 9.57e-02 | 3.94e-01 | 5.67e-02 |
| ERK/MAPK targets | 22 | 4.48e-01 | 5.33e-01 | 0.2460 | 0.020000 | -0.228000 | -0.090900 | -0.002650 | 8.71e-01 | 6.41e-02 | 4.61e-01 | 9.83e-01 |
| Nuclear signaling by ERBB4 | 20 | 5.22e-01 | 6.03e-01 | 0.2460 | 0.217000 | -0.072500 | 0.005570 | 0.089700 | 9.28e-02 | 5.75e-01 | 9.66e-01 | 4.88e-01 |
| Negative regulators of DDX58/IFIH1 signaling | 29 | 3.42e-01 | 4.29e-01 | 0.2460 | 0.043600 | -0.112000 | 0.148000 | 0.155000 | 6.85e-01 | 2.96e-01 | 1.69e-01 | 1.49e-01 |
| Ion channel transport | 89 | 8.12e-04 | 2.83e-03 | 0.2450 | 0.031400 | -0.190000 | -0.119000 | 0.095000 | 6.10e-01 | 1.98e-03 | 5.31e-02 | 1.22e-01 |
| SUMO E3 ligases SUMOylate target proteins | 131 | 1.59e-04 | 6.78e-04 | 0.2450 | -0.126000 | 0.193000 | 0.083000 | -0.010800 | 1.30e-02 | 1.41e-04 | 1.02e-01 | 8.32e-01 |
| Cyclin E associated events during G1/S transition | 75 | 2.03e-03 | 6.15e-03 | 0.2450 | -0.117000 | 0.087200 | 0.197000 | 0.015600 | 8.11e-02 | 1.93e-01 | 3.27e-03 | 8.16e-01 |
| Activation of HOX genes during differentiation | 48 | 6.31e-02 | 1.09e-01 | 0.2450 | -0.166000 | 0.156000 | 0.088100 | -0.023800 | 4.68e-02 | 6.25e-02 | 2.92e-01 | 7.76e-01 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 48 | 6.31e-02 | 1.09e-01 | 0.2450 | -0.166000 | 0.156000 | 0.088100 | -0.023800 | 4.68e-02 | 6.25e-02 | 2.92e-01 | 7.76e-01 |
| MECP2 regulates neuronal receptors and channels | 10 | 7.48e-01 | 7.98e-01 | 0.2450 | -0.141000 | 0.154000 | 0.113000 | -0.059600 | 4.39e-01 | 3.99e-01 | 5.37e-01 | 7.44e-01 |
| APC-Cdc20 mediated degradation of Nek2A | 21 | 4.75e-01 | 5.57e-01 | 0.2440 | -0.149000 | 0.192000 | 0.018800 | -0.020000 | 2.37e-01 | 1.28e-01 | 8.81e-01 | 8.74e-01 |
| EGFR downregulation | 22 | 5.40e-01 | 6.19e-01 | 0.2440 | 0.104000 | 0.154000 | 0.148000 | 0.057500 | 3.98e-01 | 2.11e-01 | 2.31e-01 | 6.41e-01 |
| PI-3K cascade:FGFR2 | 10 | 5.81e-01 | 6.59e-01 | 0.2440 | -0.120000 | -0.107000 | 0.105000 | -0.150000 | 5.12e-01 | 5.56e-01 | 5.67e-01 | 4.11e-01 |
| Late endosomal microautophagy | 23 | 1.72e-01 | 2.45e-01 | 0.2430 | -0.190000 | -0.126000 | 0.082100 | 0.014700 | 1.15e-01 | 2.95e-01 | 4.96e-01 | 9.03e-01 |
| mRNA decay by 5' to 3' exoribonuclease | 14 | 6.91e-01 | 7.51e-01 | 0.2410 | -0.187000 | 0.143000 | -0.036000 | -0.034000 | 2.25e-01 | 3.53e-01 | 8.16e-01 | 8.26e-01 |
| Regulation of PTEN mRNA translation | 11 | 4.56e-01 | 5.40e-01 | 0.2410 | 0.017000 | 0.091200 | -0.198000 | 0.102000 | 9.22e-01 | 6.00e-01 | 2.56e-01 | 5.60e-01 |
| Diseases of metabolism | 152 | 1.38e-04 | 6.07e-04 | 0.2400 | 0.181000 | -0.128000 | -0.015300 | 0.091800 | 1.26e-04 | 6.51e-03 | 7.46e-01 | 5.18e-02 |
| Ub-specific processing proteases | 145 | 1.30e-05 | 7.43e-05 | 0.2400 | -0.188000 | 0.099200 | 0.088600 | -0.068200 | 9.82e-05 | 3.99e-02 | 6.66e-02 | 1.58e-01 |
| Regulation of RUNX2 expression and activity | 61 | 8.65e-03 | 2.09e-02 | 0.2400 | -0.188000 | 0.041300 | 0.105000 | -0.096400 | 1.10e-02 | 5.78e-01 | 1.56e-01 | 1.93e-01 |
| Asymmetric localization of PCP proteins | 55 | 7.20e-03 | 1.80e-02 | 0.2390 | -0.145000 | 0.044300 | 0.176000 | -0.057200 | 6.39e-02 | 5.70e-01 | 2.38e-02 | 4.64e-01 |
| Ion transport by P-type ATPases | 33 | 2.46e-01 | 3.28e-01 | 0.2380 | 0.044000 | -0.225000 | -0.052300 | 0.042100 | 6.62e-01 | 2.57e-02 | 6.03e-01 | 6.76e-01 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 13 | 5.05e-01 | 5.87e-01 | 0.2380 | -0.123000 | 0.117000 | 0.021300 | 0.166000 | 4.44e-01 | 4.66e-01 | 8.94e-01 | 2.99e-01 |
| Miscellaneous transport and binding events | 16 | 3.46e-01 | 4.32e-01 | 0.2380 | -0.105000 | 0.150000 | -0.092400 | 0.121000 | 4.68e-01 | 2.98e-01 | 5.22e-01 | 4.04e-01 |
| Death Receptor Signalling | 106 | 6.20e-03 | 1.58e-02 | 0.2370 | 0.117000 | -0.171000 | 0.039000 | 0.109000 | 3.86e-02 | 2.41e-03 | 4.89e-01 | 5.40e-02 |
| Signaling by TGF-beta Receptor Complex | 66 | 5.90e-03 | 1.52e-02 | 0.2360 | -0.095100 | 0.119000 | 0.160000 | -0.082400 | 1.82e-01 | 9.52e-02 | 2.48e-02 | 2.48e-01 |
| PI-3K cascade:FGFR4 | 10 | 7.96e-01 | 8.36e-01 | 0.2360 | -0.143000 | -0.105000 | -0.007770 | -0.154000 | 4.32e-01 | 5.66e-01 | 9.66e-01 | 3.98e-01 |
| Factors involved in megakaryocyte development and platelet production | 80 | 2.41e-02 | 4.87e-02 | 0.2350 | 0.193000 | -0.114000 | 0.040200 | 0.058600 | 2.86e-03 | 7.98e-02 | 5.35e-01 | 3.66e-01 |
| Signaling by KIT in disease | 17 | 6.28e-01 | 6.98e-01 | 0.2350 | 0.110000 | -0.139000 | -0.004830 | 0.155000 | 4.32e-01 | 3.23e-01 | 9.73e-01 | 2.70e-01 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 17 | 6.28e-01 | 6.98e-01 | 0.2350 | 0.110000 | -0.139000 | -0.004830 | 0.155000 | 4.32e-01 | 3.23e-01 | 9.73e-01 | 2.70e-01 |
| Growth hormone receptor signaling | 17 | 6.87e-01 | 7.48e-01 | 0.2350 | 0.187000 | -0.083400 | 0.097600 | 0.060600 | 1.82e-01 | 5.52e-01 | 4.86e-01 | 6.65e-01 |
| RHO GTPases Activate NADPH Oxidases | 13 | 7.97e-01 | 8.36e-01 | 0.2350 | 0.141000 | -0.059100 | 0.163000 | 0.072500 | 3.80e-01 | 7.12e-01 | 3.09e-01 | 6.51e-01 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 50 | 1.19e-02 | 2.73e-02 | 0.2350 | -0.066600 | -0.095700 | -0.184000 | 0.086700 | 4.16e-01 | 2.43e-01 | 2.43e-02 | 2.89e-01 |
| Cyclin D associated events in G1 | 41 | 3.68e-01 | 4.53e-01 | 0.2340 | 0.088900 | 0.078400 | 0.175000 | 0.101000 | 3.25e-01 | 3.86e-01 | 5.30e-02 | 2.63e-01 |
| G1 Phase | 41 | 3.68e-01 | 4.53e-01 | 0.2340 | 0.088900 | 0.078400 | 0.175000 | 0.101000 | 3.25e-01 | 3.86e-01 | 5.30e-02 | 2.63e-01 |
| Glycolysis | 53 | 8.94e-02 | 1.44e-01 | 0.2340 | -0.198000 | 0.117000 | -0.016500 | -0.041400 | 1.28e-02 | 1.41e-01 | 8.35e-01 | 6.03e-01 |
| Glycerophospholipid biosynthesis | 80 | 4.43e-03 | 1.21e-02 | 0.2340 | 0.080000 | -0.146000 | -0.159000 | 0.042700 | 2.17e-01 | 2.39e-02 | 1.43e-02 | 5.10e-01 |
| Metabolism of amino acids and derivatives | 223 | 9.82e-09 | 1.12e-07 | 0.2330 | -0.162000 | -0.071100 | 0.039700 | -0.147000 | 3.37e-05 | 6.89e-02 | 3.10e-01 | 1.69e-04 |
| Netrin-1 signaling | 37 | 2.27e-01 | 3.07e-01 | 0.2330 | 0.098500 | -0.209000 | -0.029400 | 0.004580 | 3.00e-01 | 2.78e-02 | 7.58e-01 | 9.62e-01 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 36 | 1.25e-01 | 1.88e-01 | 0.2330 | -0.196000 | 0.085500 | 0.092200 | 0.001590 | 4.18e-02 | 3.75e-01 | 3.39e-01 | 9.87e-01 |
| AURKA Activation by TPX2 | 62 | 1.54e-02 | 3.34e-02 | 0.2320 | 0.007660 | 0.121000 | 0.022700 | 0.197000 | 9.17e-01 | 9.93e-02 | 7.57e-01 | 7.45e-03 |
| ABC transporter disorders | 56 | 1.39e-02 | 3.08e-02 | 0.2320 | -0.196000 | 0.035000 | 0.119000 | -0.011700 | 1.13e-02 | 6.51e-01 | 1.25e-01 | 8.80e-01 |
| DNA Damage Bypass | 43 | 1.35e-01 | 1.97e-01 | 0.2310 | -0.094700 | 0.155000 | 0.101000 | 0.099400 | 2.83e-01 | 7.83e-02 | 2.53e-01 | 2.60e-01 |
| Pre-NOTCH Transcription and Translation | 31 | 5.33e-01 | 6.13e-01 | 0.2300 | 0.101000 | 0.034500 | 0.096400 | 0.180000 | 3.30e-01 | 7.40e-01 | 3.53e-01 | 8.35e-02 |
| DNA Repair | 241 | 2.81e-07 | 2.54e-06 | 0.2290 | -0.117000 | 0.183000 | 0.071800 | 0.016700 | 1.91e-03 | 1.16e-06 | 5.65e-02 | 6.57e-01 |
| Transmission across Chemical Synapses | 123 | 2.22e-03 | 6.67e-03 | 0.2290 | 0.114000 | -0.184000 | -0.004960 | 0.074500 | 2.96e-02 | 4.52e-04 | 9.24e-01 | 1.55e-01 |
| Ca2+ pathway | 45 | 3.54e-02 | 6.87e-02 | 0.2290 | 0.168000 | -0.022300 | -0.153000 | -0.002630 | 5.09e-02 | 7.96e-01 | 7.61e-02 | 9.76e-01 |
| VLDLR internalisation and degradation | 11 | 7.75e-01 | 8.21e-01 | 0.2280 | 0.019900 | -0.169000 | 0.077200 | 0.131000 | 9.09e-01 | 3.31e-01 | 6.58e-01 | 4.53e-01 |
| HDR through Single Strand Annealing (SSA) | 30 | 2.76e-01 | 3.57e-01 | 0.2280 | -0.055300 | 0.197000 | 0.024000 | 0.097200 | 6.00e-01 | 6.18e-02 | 8.20e-01 | 3.57e-01 |
| RNA Polymerase I Promoter Clearance | 43 | 1.49e-01 | 2.15e-01 | 0.2280 | -0.041000 | 0.162000 | 0.155000 | -0.006470 | 6.42e-01 | 6.69e-02 | 7.95e-02 | 9.42e-01 |
| Signaling by PDGFR in disease | 17 | 6.15e-01 | 6.91e-01 | 0.2270 | -0.061400 | 0.093400 | 0.185000 | 0.068000 | 6.61e-01 | 5.05e-01 | 1.86e-01 | 6.27e-01 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 24 | 3.24e-01 | 4.07e-01 | 0.2260 | -0.183000 | 0.081100 | 0.105000 | 0.013500 | 1.21e-01 | 4.92e-01 | 3.72e-01 | 9.09e-01 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | 25 | 2.66e-01 | 3.46e-01 | 0.2260 | -0.161000 | 0.056900 | 0.148000 | 0.006840 | 1.63e-01 | 6.23e-01 | 2.00e-01 | 9.53e-01 |
| DNA Double Strand Break Response | 37 | 1.55e-01 | 2.22e-01 | 0.2260 | -0.164000 | 0.110000 | 0.108000 | 0.018900 | 8.45e-02 | 2.46e-01 | 2.55e-01 | 8.42e-01 |
| Regulation of TP53 Activity through Association with Co-factors | 12 | 9.06e-01 | 9.23e-01 | 0.2260 | 0.125000 | 0.018100 | 0.112000 | 0.150000 | 4.52e-01 | 9.14e-01 | 5.01e-01 | 3.70e-01 |
| Notch-HLH transcription pathway | 24 | 3.63e-01 | 4.49e-01 | 0.2260 | -0.073400 | -0.205000 | 0.014100 | -0.056900 | 5.34e-01 | 8.18e-02 | 9.05e-01 | 6.30e-01 |
| SLC transporter disorders | 51 | 1.15e-01 | 1.77e-01 | 0.2260 | -0.058600 | 0.104000 | 0.141000 | 0.129000 | 4.70e-01 | 2.01e-01 | 8.12e-02 | 1.11e-01 |
| TP53 Regulates Metabolic Genes | 79 | 2.25e-02 | 4.63e-02 | 0.2250 | -0.197000 | -0.068400 | -0.069300 | -0.049900 | 2.54e-03 | 2.95e-01 | 2.88e-01 | 4.44e-01 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 15 | 8.05e-01 | 8.43e-01 | 0.2250 | 0.055100 | 0.061500 | 0.187000 | 0.091800 | 7.12e-01 | 6.80e-01 | 2.09e-01 | 5.39e-01 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 34 | 2.50e-01 | 3.32e-01 | 0.2240 | -0.077500 | 0.113000 | 0.117000 | 0.134000 | 4.34e-01 | 2.56e-01 | 2.40e-01 | 1.76e-01 |
| VEGFR2 mediated vascular permeability | 23 | 6.59e-01 | 7.24e-01 | 0.2240 | 0.077900 | -0.078700 | 0.119000 | 0.154000 | 5.18e-01 | 5.14e-01 | 3.23e-01 | 2.01e-01 |
| Diseases associated with glycosylation precursor biosynthesis | 18 | 6.34e-01 | 7.00e-01 | 0.2240 | 0.199000 | 0.035800 | 0.087900 | 0.039200 | 1.44e-01 | 7.92e-01 | 5.19e-01 | 7.73e-01 |
| Metabolism of carbohydrates | 202 | 1.04e-04 | 4.73e-04 | 0.2240 | 0.122000 | -0.149000 | 0.036300 | 0.108000 | 2.96e-03 | 2.81e-04 | 3.76e-01 | 8.25e-03 |
| ABC-family proteins mediated transport | 76 | 4.90e-02 | 8.95e-02 | 0.2240 | -0.193000 | 0.051100 | -0.012600 | -0.100000 | 3.72e-03 | 4.42e-01 | 8.49e-01 | 1.31e-01 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 36 | 1.34e-01 | 1.97e-01 | 0.2230 | 0.082000 | -0.166000 | 0.122000 | -0.024300 | 3.95e-01 | 8.49e-02 | 2.05e-01 | 8.01e-01 |
| Signaling by RAS mutants | 36 | 1.34e-01 | 1.97e-01 | 0.2230 | 0.082000 | -0.166000 | 0.122000 | -0.024300 | 3.95e-01 | 8.49e-02 | 2.05e-01 | 8.01e-01 |
| Signaling by moderate kinase activity BRAF mutants | 36 | 1.34e-01 | 1.97e-01 | 0.2230 | 0.082000 | -0.166000 | 0.122000 | -0.024300 | 3.95e-01 | 8.49e-02 | 2.05e-01 | 8.01e-01 |
| Signaling downstream of RAS mutants | 36 | 1.34e-01 | 1.97e-01 | 0.2230 | 0.082000 | -0.166000 | 0.122000 | -0.024300 | 3.95e-01 | 8.49e-02 | 2.05e-01 | 8.01e-01 |
| Synthesis of PA | 21 | 4.83e-01 | 5.64e-01 | 0.2230 | 0.096000 | -0.132000 | -0.152000 | 0.004940 | 4.47e-01 | 2.95e-01 | 2.28e-01 | 9.69e-01 |
| Integration of energy metabolism | 71 | 3.66e-02 | 7.07e-02 | 0.2230 | 0.111000 | -0.185000 | -0.052800 | -0.021300 | 1.07e-01 | 7.09e-03 | 4.43e-01 | 7.56e-01 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 13 | 6.18e-01 | 6.94e-01 | 0.2230 | -0.159000 | 0.113000 | -0.096400 | 0.050000 | 3.22e-01 | 4.81e-01 | 5.47e-01 | 7.55e-01 |
| Phosphorylation of the APC/C | 18 | 5.85e-01 | 6.62e-01 | 0.2230 | -0.161000 | 0.139000 | -0.066000 | 0.002330 | 2.36e-01 | 3.07e-01 | 6.28e-01 | 9.86e-01 |
| RNA Polymerase I Transcription | 44 | 1.30e-01 | 1.92e-01 | 0.2230 | -0.022000 | 0.145000 | 0.167000 | -0.017900 | 8.01e-01 | 9.64e-02 | 5.57e-02 | 8.38e-01 |
| Regulation of TP53 Degradation | 32 | 3.50e-01 | 4.36e-01 | 0.2220 | -0.061600 | 0.210000 | 0.037200 | -0.000708 | 5.47e-01 | 3.96e-02 | 7.16e-01 | 9.94e-01 |
| Post NMDA receptor activation events | 44 | 1.16e-01 | 1.77e-01 | 0.2220 | 0.096100 | -0.187000 | -0.003140 | -0.071000 | 2.71e-01 | 3.18e-02 | 9.71e-01 | 4.16e-01 |
| Protein methylation | 10 | 6.94e-01 | 7.53e-01 | 0.2220 | -0.185000 | -0.003720 | 0.123000 | 0.007660 | 3.12e-01 | 9.84e-01 | 5.01e-01 | 9.67e-01 |
| RAS processing | 18 | 5.33e-01 | 6.13e-01 | 0.2210 | 0.112000 | -0.155000 | 0.109000 | -0.013600 | 4.12e-01 | 2.54e-01 | 4.23e-01 | 9.20e-01 |
| Purine salvage | 13 | 7.17e-01 | 7.72e-01 | 0.2190 | 0.054400 | -0.207000 | 0.040100 | -0.025800 | 7.34e-01 | 1.96e-01 | 8.02e-01 | 8.72e-01 |
| Signaling by ERBB2 | 37 | 3.75e-01 | 4.59e-01 | 0.2190 | 0.045800 | -0.070200 | 0.116000 | 0.166000 | 6.30e-01 | 4.60e-01 | 2.24e-01 | 8.14e-02 |
| Regulation of TP53 Activity through Acetylation | 28 | 4.72e-01 | 5.55e-01 | 0.2180 | -0.030900 | 0.162000 | 0.138000 | 0.034200 | 7.77e-01 | 1.38e-01 | 2.08e-01 | 7.54e-01 |
| Glucose metabolism | 67 | 1.83e-01 | 2.55e-01 | 0.2170 | -0.171000 | -0.013800 | -0.082300 | -0.105000 | 1.59e-02 | 8.46e-01 | 2.45e-01 | 1.37e-01 |
| Signaling by FGFR4 in disease | 11 | 7.49e-01 | 7.99e-01 | 0.2170 | -0.188000 | -0.042000 | -0.098700 | 0.016200 | 2.81e-01 | 8.09e-01 | 5.71e-01 | 9.26e-01 |
| Purine catabolism | 14 | 5.85e-01 | 6.62e-01 | 0.2160 | 0.041600 | -0.118000 | -0.129000 | 0.119000 | 7.88e-01 | 4.44e-01 | 4.02e-01 | 4.41e-01 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 10 | 8.46e-01 | 8.78e-01 | 0.2150 | -0.062700 | -0.197000 | -0.034200 | -0.050900 | 7.32e-01 | 2.82e-01 | 8.51e-01 | 7.80e-01 |
| alpha-linolenic acid (ALA) metabolism | 10 | 8.46e-01 | 8.78e-01 | 0.2150 | -0.062700 | -0.197000 | -0.034200 | -0.050900 | 7.32e-01 | 2.82e-01 | 8.51e-01 | 7.80e-01 |
| Activated NTRK2 signals through FRS2 and FRS3 | 10 | 7.85e-01 | 8.28e-01 | 0.2150 | -0.101000 | 0.048200 | 0.174000 | 0.060300 | 5.80e-01 | 7.92e-01 | 3.42e-01 | 7.41e-01 |
| Signaling by FGFR1 | 34 | 4.07e-01 | 4.89e-01 | 0.2140 | 0.108000 | 0.089500 | 0.158000 | 0.036200 | 2.76e-01 | 3.67e-01 | 1.12e-01 | 7.15e-01 |
| Cellular responses to external stimuli | 410 | 9.01e-15 | 2.91e-13 | 0.2140 | -0.080800 | 0.050200 | 0.191000 | 0.012100 | 5.46e-03 | 8.46e-02 | 4.61e-11 | 6.78e-01 |
| Cellular responses to stress | 406 | 8.22e-15 | 2.73e-13 | 0.2140 | -0.082700 | 0.049300 | 0.191000 | 0.007360 | 4.65e-03 | 9.18e-02 | 6.61e-11 | 8.01e-01 |
| Budding and maturation of HIV virion | 22 | 4.32e-01 | 5.15e-01 | 0.2130 | -0.115000 | 0.047600 | 0.137000 | 0.106000 | 3.52e-01 | 6.99e-01 | 2.66e-01 | 3.88e-01 |
| Activation of NMDA receptors and postsynaptic events | 52 | 1.26e-01 | 1.89e-01 | 0.2130 | 0.112000 | -0.180000 | 0.022700 | -0.009840 | 1.63e-01 | 2.53e-02 | 7.78e-01 | 9.02e-01 |
| ERKs are inactivated | 13 | 8.53e-01 | 8.85e-01 | 0.2130 | 0.145000 | -0.081000 | 0.115000 | 0.065800 | 3.64e-01 | 6.13e-01 | 4.74e-01 | 6.82e-01 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | 19 | 5.01e-01 | 5.82e-01 | 0.2120 | 0.039100 | -0.189000 | 0.054100 | -0.068500 | 7.68e-01 | 1.54e-01 | 6.83e-01 | 6.06e-01 |
| Trafficking of AMPA receptors | 19 | 5.01e-01 | 5.82e-01 | 0.2120 | 0.039100 | -0.189000 | 0.054100 | -0.068500 | 7.68e-01 | 1.54e-01 | 6.83e-01 | 6.06e-01 |
| APC/C:Cdc20 mediated degradation of Cyclin B | 20 | 6.29e-01 | 6.98e-01 | 0.2120 | -0.135000 | 0.163000 | 0.000970 | -0.007480 | 2.98e-01 | 2.06e-01 | 9.94e-01 | 9.54e-01 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 29 | 4.00e-01 | 4.84e-01 | 0.2120 | -0.121000 | 0.021500 | -0.171000 | -0.019700 | 2.60e-01 | 8.41e-01 | 1.11e-01 | 8.54e-01 |
| Interleukin-2 family signaling | 22 | 5.91e-01 | 6.67e-01 | 0.2110 | 0.078300 | -0.167000 | 0.087800 | 0.052000 | 5.25e-01 | 1.74e-01 | 4.76e-01 | 6.73e-01 |
| WNT ligand biogenesis and trafficking | 12 | 8.22e-01 | 8.57e-01 | 0.2110 | -0.157000 | -0.103000 | -0.026000 | -0.093100 | 3.48e-01 | 5.38e-01 | 8.76e-01 | 5.77e-01 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | 28 | 1.39e-01 | 2.02e-01 | 0.2110 | -0.070500 | -0.083800 | -0.082100 | 0.160000 | 5.19e-01 | 4.43e-01 | 4.52e-01 | 1.43e-01 |
| Metabolism of vitamins and cofactors | 126 | 7.04e-03 | 1.76e-02 | 0.2100 | -0.025600 | -0.071000 | -0.186000 | -0.061800 | 6.21e-01 | 1.70e-01 | 3.17e-04 | 2.32e-01 |
| FGFR1 mutant receptor activation | 23 | 6.73e-01 | 7.36e-01 | 0.2100 | -0.065400 | -0.003300 | -0.079200 | -0.183000 | 5.88e-01 | 9.78e-01 | 5.11e-01 | 1.28e-01 |
| Deubiquitination | 211 | 2.62e-06 | 1.81e-05 | 0.2100 | -0.167000 | 0.085400 | 0.079500 | -0.050800 | 3.06e-05 | 3.35e-02 | 4.76e-02 | 2.06e-01 |
| Transcriptional regulation by RUNX3 | 86 | 1.52e-02 | 3.29e-02 | 0.2100 | -0.001530 | 0.005910 | 0.203000 | 0.055100 | 9.80e-01 | 9.25e-01 | 1.19e-03 | 3.78e-01 |
| Resolution of Abasic Sites (AP sites) | 36 | 2.55e-01 | 3.37e-01 | 0.2090 | -0.095500 | 0.083500 | 0.130000 | 0.104000 | 3.22e-01 | 3.86e-01 | 1.77e-01 | 2.80e-01 |
| Regulation of TP53 Expression and Degradation | 33 | 3.72e-01 | 4.57e-01 | 0.2090 | -0.038400 | 0.205000 | 0.009130 | 0.001060 | 7.03e-01 | 4.13e-02 | 9.28e-01 | 9.92e-01 |
| Programmed Cell Death | 143 | 1.57e-03 | 4.96e-03 | 0.2090 | 0.011700 | -0.046800 | 0.174000 | 0.105000 | 8.09e-01 | 3.36e-01 | 3.31e-04 | 3.13e-02 |
| Negative regulation of MAPK pathway | 39 | 7.68e-02 | 1.28e-01 | 0.2090 | -0.057600 | 0.058500 | 0.158000 | -0.109000 | 5.34e-01 | 5.27e-01 | 8.78e-02 | 2.41e-01 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | 35 | 3.55e-01 | 4.41e-01 | 0.2090 | 0.035300 | 0.074500 | 0.056100 | 0.183000 | 7.18e-01 | 4.46e-01 | 5.66e-01 | 6.08e-02 |
| Diseases of mitotic cell cycle | 35 | 3.55e-01 | 4.41e-01 | 0.2090 | 0.035300 | 0.074500 | 0.056100 | 0.183000 | 7.18e-01 | 4.46e-01 | 5.66e-01 | 6.08e-02 |
| Signaling by NOTCH4 | 70 | 1.38e-02 | 3.07e-02 | 0.2080 | -0.096700 | 0.025300 | 0.181000 | 0.024600 | 1.63e-01 | 7.15e-01 | 8.98e-03 | 7.23e-01 |
| Cilium Assembly | 158 | 1.49e-05 | 8.41e-05 | 0.2080 | 0.082500 | 0.114000 | -0.038800 | 0.148000 | 7.47e-02 | 1.35e-02 | 4.02e-01 | 1.38e-03 |
| Anchoring of the basal body to the plasma membrane | 83 | 2.72e-02 | 5.42e-02 | 0.2080 | 0.085300 | 0.122000 | 0.016300 | 0.144000 | 1.80e-01 | 5.55e-02 | 7.98e-01 | 2.32e-02 |
| FRS-mediated FGFR3 signaling | 12 | 7.13e-01 | 7.70e-01 | 0.2080 | -0.043000 | 0.086200 | 0.179000 | -0.042000 | 7.96e-01 | 6.05e-01 | 2.83e-01 | 8.01e-01 |
| PKMTs methylate histone lysines | 37 | 3.58e-01 | 4.44e-01 | 0.2070 | -0.124000 | 0.153000 | -0.057200 | -0.030600 | 1.91e-01 | 1.08e-01 | 5.47e-01 | 7.48e-01 |
| Signalling to ERKs | 29 | 1.76e-01 | 2.49e-01 | 0.2070 | 0.084500 | -0.058400 | 0.167000 | -0.065700 | 4.31e-01 | 5.87e-01 | 1.19e-01 | 5.40e-01 |
| Gene expression (Transcription) | 991 | 2.62e-23 | 2.30e-21 | 0.2070 | -0.086500 | 0.168000 | 0.068900 | -0.047700 | 7.04e-06 | 2.71e-18 | 3.45e-04 | 1.33e-02 |
| Clathrin-mediated endocytosis | 108 | 8.07e-02 | 1.33e-01 | 0.2060 | 0.079300 | 0.095300 | 0.121000 | 0.112000 | 1.56e-01 | 8.78e-02 | 3.03e-02 | 4.57e-02 |
| Extra-nuclear estrogen signaling | 53 | 2.42e-01 | 3.22e-01 | 0.2060 | 0.171000 | 0.041900 | 0.039900 | 0.097700 | 3.11e-02 | 5.98e-01 | 6.15e-01 | 2.19e-01 |
| Loss of Nlp from mitotic centrosomes | 60 | 4.56e-02 | 8.43e-02 | 0.2050 | 0.000986 | 0.100000 | 0.014700 | 0.178000 | 9.89e-01 | 1.79e-01 | 8.44e-01 | 1.72e-02 |
| Loss of proteins required for interphase microtubule organization from the centrosome | 60 | 4.56e-02 | 8.43e-02 | 0.2050 | 0.000986 | 0.100000 | 0.014700 | 0.178000 | 9.89e-01 | 1.79e-01 | 8.44e-01 | 1.72e-02 |
| Disorders of transmembrane transporters | 107 | 2.01e-03 | 6.11e-03 | 0.2050 | -0.131000 | 0.068100 | 0.130000 | 0.055800 | 1.94e-02 | 2.25e-01 | 2.04e-02 | 3.20e-01 |
| Glutamate Neurotransmitter Release Cycle | 12 | 8.35e-01 | 8.68e-01 | 0.2040 | -0.015100 | -0.024700 | 0.150000 | 0.136000 | 9.28e-01 | 8.82e-01 | 3.70e-01 | 4.14e-01 |
| Apoptosis | 133 | 1.74e-03 | 5.37e-03 | 0.2040 | -0.008730 | -0.041600 | 0.177000 | 0.092800 | 8.63e-01 | 4.09e-01 | 4.52e-04 | 6.56e-02 |
| Base Excision Repair | 43 | 3.24e-01 | 4.07e-01 | 0.2040 | -0.033900 | 0.110000 | 0.122000 | 0.115000 | 7.01e-01 | 2.13e-01 | 1.66e-01 | 1.91e-01 |
| G2/M Transition | 153 | 1.14e-03 | 3.78e-03 | 0.2040 | -0.080800 | 0.145000 | 0.111000 | 0.041500 | 8.56e-02 | 2.10e-03 | 1.85e-02 | 3.77e-01 |
| Uptake and actions of bacterial toxins | 21 | 5.00e-01 | 5.82e-01 | 0.2030 | 0.105000 | -0.127000 | 0.118000 | -0.021500 | 4.05e-01 | 3.15e-01 | 3.50e-01 | 8.65e-01 |
| Cytochrome c-mediated apoptotic response | 10 | 9.17e-01 | 9.32e-01 | 0.2020 | 0.083800 | -0.009820 | 0.170000 | 0.071000 | 6.47e-01 | 9.57e-01 | 3.53e-01 | 6.98e-01 |
| Signal Transduction | 1391 | 1.67e-19 | 1.02e-17 | 0.2020 | 0.131000 | -0.061600 | 0.103000 | 0.097200 | 3.38e-15 | 2.07e-04 | 6.46e-10 | 4.75e-09 |
| RNA Polymerase I Transcription Initiation | 40 | 2.62e-01 | 3.44e-01 | 0.2020 | -0.065500 | 0.145000 | 0.119000 | -0.037000 | 4.74e-01 | 1.14e-01 | 1.94e-01 | 6.86e-01 |
| C-type lectin receptors (CLRs) | 94 | 1.17e-03 | 3.86e-03 | 0.2010 | -0.140000 | -0.016300 | 0.141000 | -0.026200 | 1.92e-02 | 7.86e-01 | 1.81e-02 | 6.61e-01 |
| Biological oxidations | 85 | 9.24e-02 | 1.47e-01 | 0.2010 | 0.002580 | -0.141000 | -0.118000 | -0.081000 | 9.67e-01 | 2.52e-02 | 5.96e-02 | 1.98e-01 |
| Amino acids regulate mTORC1 | 45 | 1.03e-01 | 1.61e-01 | 0.2010 | -0.094600 | -0.044400 | 0.125000 | 0.117000 | 2.73e-01 | 6.07e-01 | 1.47e-01 | 1.74e-01 |
| Developmental Biology | 582 | 1.14e-09 | 1.50e-08 | 0.2000 | 0.082000 | -0.070400 | 0.136000 | 0.100000 | 8.67e-04 | 4.27e-03 | 3.32e-08 | 4.81e-05 |
| Signaling by FGFR3 | 29 | 3.85e-01 | 4.68e-01 | 0.2000 | 0.036100 | 0.099800 | 0.168000 | -0.021500 | 7.37e-01 | 3.53e-01 | 1.17e-01 | 8.41e-01 |
| Interleukin-7 signaling | 12 | 8.55e-01 | 8.86e-01 | 0.2000 | 0.087500 | -0.167000 | -0.042600 | 0.050800 | 6.00e-01 | 3.17e-01 | 7.99e-01 | 7.61e-01 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 20 | 7.25e-01 | 7.79e-01 | 0.2000 | 0.026000 | -0.103000 | -0.116000 | -0.122000 | 8.41e-01 | 4.25e-01 | 3.69e-01 | 3.43e-01 |
| Downstream signal transduction | 27 | 4.29e-01 | 5.12e-01 | 0.1990 | 0.048500 | -0.175000 | 0.080900 | -0.006370 | 6.63e-01 | 1.15e-01 | 4.67e-01 | 9.54e-01 |
| PI3K Cascade | 23 | 5.69e-01 | 6.47e-01 | 0.1990 | -0.158000 | 0.015700 | 0.036000 | -0.115000 | 1.91e-01 | 8.97e-01 | 7.65e-01 | 3.42e-01 |
| Apoptotic execution phase | 35 | 6.34e-01 | 7.00e-01 | 0.1990 | 0.083600 | -0.039200 | 0.105000 | 0.141000 | 3.93e-01 | 6.88e-01 | 2.84e-01 | 1.49e-01 |
| Signaling by FGFR1 in disease | 30 | 7.34e-01 | 7.84e-01 | 0.1990 | -0.099100 | 0.012700 | -0.103000 | -0.137000 | 3.48e-01 | 9.04e-01 | 3.29e-01 | 1.94e-01 |
| COPI-independent Golgi-to-ER retrograde traffic | 27 | 2.93e-01 | 3.76e-01 | 0.1980 | -0.187000 | 0.012000 | 0.006170 | 0.064400 | 9.32e-02 | 9.14e-01 | 9.56e-01 | 5.63e-01 |
| Mitotic G2-G2/M phases | 155 | 1.61e-03 | 5.04e-03 | 0.1980 | -0.075900 | 0.137000 | 0.113000 | 0.042800 | 1.04e-01 | 3.34e-03 | 1.54e-02 | 3.60e-01 |
| Cargo trafficking to the periciliary membrane | 42 | 1.18e-01 | 1.80e-01 | 0.1960 | 0.043000 | 0.138000 | -0.059600 | 0.118000 | 6.30e-01 | 1.22e-01 | 5.04e-01 | 1.85e-01 |
| Asparagine N-linked glycosylation | 237 | 1.90e-03 | 5.83e-03 | 0.1960 | 0.049600 | 0.056000 | 0.114000 | 0.141000 | 1.91e-01 | 1.40e-01 | 2.66e-03 | 2.10e-04 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | 20 | 5.48e-01 | 6.27e-01 | 0.1960 | -0.133000 | 0.121000 | -0.000105 | 0.076900 | 3.03e-01 | 3.49e-01 | 9.99e-01 | 5.52e-01 |
| Signaling by Insulin receptor | 48 | 2.01e-01 | 2.77e-01 | 0.1950 | -0.044700 | 0.042300 | 0.102000 | 0.155000 | 5.92e-01 | 6.13e-01 | 2.20e-01 | 6.42e-02 |
| Downregulation of ERBB2 signaling | 18 | 7.54e-01 | 8.04e-01 | 0.1940 | -0.003720 | -0.026500 | 0.121000 | 0.149000 | 9.78e-01 | 8.46e-01 | 3.73e-01 | 2.73e-01 |
| Regulation of PTEN gene transcription | 57 | 9.16e-02 | 1.47e-01 | 0.1940 | 0.080800 | 0.052300 | 0.168000 | -0.017300 | 2.92e-01 | 4.95e-01 | 2.88e-02 | 8.22e-01 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 19 | 7.87e-01 | 8.29e-01 | 0.1920 | -0.108000 | 0.116000 | -0.090300 | -0.059900 | 4.16e-01 | 3.80e-01 | 4.96e-01 | 6.52e-01 |
| PCP/CE pathway | 79 | 1.38e-02 | 3.07e-02 | 0.1920 | -0.037400 | -0.013100 | 0.187000 | 0.008030 | 5.67e-01 | 8.41e-01 | 4.09e-03 | 9.02e-01 |
| Signaling by BRAF and RAF fusions | 52 | 1.92e-01 | 2.66e-01 | 0.1910 | 0.046400 | -0.173000 | 0.063500 | 0.019900 | 5.63e-01 | 3.12e-02 | 4.29e-01 | 8.05e-01 |
| Intra-Golgi traffic | 38 | 3.60e-01 | 4.46e-01 | 0.1910 | -0.119000 | 0.128000 | 0.073200 | 0.022400 | 2.05e-01 | 1.71e-01 | 4.35e-01 | 8.12e-01 |
| Fc epsilon receptor (FCERI) signaling | 104 | 2.24e-03 | 6.72e-03 | 0.1910 | -0.143000 | 0.015500 | 0.119000 | -0.039100 | 1.17e-02 | 7.86e-01 | 3.67e-02 | 4.91e-01 |
| Signaling by TGFB family members | 84 | 3.79e-03 | 1.07e-02 | 0.1910 | -0.042100 | 0.053600 | 0.111000 | -0.139000 | 5.05e-01 | 3.97e-01 | 7.83e-02 | 2.81e-02 |
| VxPx cargo-targeting to cilium | 17 | 4.61e-01 | 5.44e-01 | 0.1900 | -0.027800 | -0.040700 | -0.118000 | 0.141000 | 8.43e-01 | 7.72e-01 | 3.99e-01 | 3.16e-01 |
| Interconversion of nucleotide di- and triphosphates | 21 | 7.82e-01 | 8.26e-01 | 0.1900 | 0.112000 | -0.096000 | 0.099800 | 0.066500 | 3.75e-01 | 4.46e-01 | 4.29e-01 | 5.98e-01 |
| NR1H2 and NR1H3-mediated signaling | 34 | 6.63e-01 | 7.27e-01 | 0.1900 | -0.086500 | -0.097800 | -0.112000 | -0.080600 | 3.83e-01 | 3.24e-01 | 2.60e-01 | 4.17e-01 |
| Platelet homeostasis | 50 | 2.42e-01 | 3.23e-01 | 0.1900 | 0.155000 | -0.108000 | -0.004730 | 0.009030 | 5.75e-02 | 1.86e-01 | 9.54e-01 | 9.12e-01 |
| Regulation of FZD by ubiquitination | 11 | 7.07e-01 | 7.65e-01 | 0.1880 | -0.030300 | -0.101000 | 0.118000 | -0.101000 | 8.62e-01 | 5.62e-01 | 4.97e-01 | 5.63e-01 |
| Regulation of localization of FOXO transcription factors | 11 | 8.31e-01 | 8.64e-01 | 0.1870 | -0.100000 | -0.139000 | -0.063200 | 0.037100 | 5.65e-01 | 4.24e-01 | 7.17e-01 | 8.31e-01 |
| PI Metabolism | 68 | 1.18e-01 | 1.80e-01 | 0.1870 | 0.022000 | 0.098900 | 0.037600 | 0.152000 | 7.54e-01 | 1.59e-01 | 5.93e-01 | 3.04e-02 |
| Nucleobase catabolism | 21 | 6.29e-01 | 6.98e-01 | 0.1860 | 0.017000 | -0.146000 | -0.091700 | 0.068900 | 8.93e-01 | 2.49e-01 | 4.67e-01 | 5.85e-01 |
| Signaling by WNT in cancer | 28 | 6.63e-01 | 7.27e-01 | 0.1860 | -0.167000 | 0.036600 | -0.038400 | -0.060300 | 1.26e-01 | 7.38e-01 | 7.25e-01 | 5.81e-01 |
| NRIF signals cell death from the nucleus | 13 | 8.21e-01 | 8.57e-01 | 0.1850 | 0.131000 | 0.075700 | 0.106000 | -0.006480 | 4.12e-01 | 6.37e-01 | 5.06e-01 | 9.68e-01 |
| Signaling by EGFR in Cancer | 18 | 7.87e-01 | 8.28e-01 | 0.1850 | -0.033100 | 0.112000 | 0.138000 | 0.038500 | 8.08e-01 | 4.10e-01 | 3.09e-01 | 7.77e-01 |
| NOTCH3 Intracellular Domain Regulates Transcription | 18 | 8.64e-01 | 8.92e-01 | 0.1850 | 0.096500 | -0.045000 | 0.053900 | 0.142000 | 4.79e-01 | 7.41e-01 | 6.92e-01 | 2.99e-01 |
| Transcriptional regulation of white adipocyte differentiation | 71 | 1.26e-01 | 1.89e-01 | 0.1850 | -0.105000 | 0.147000 | 0.034700 | 0.015600 | 1.25e-01 | 3.22e-02 | 6.14e-01 | 8.20e-01 |
| Signaling by EGFR | 41 | 6.58e-01 | 7.24e-01 | 0.1850 | 0.073400 | 0.044000 | 0.129000 | 0.102000 | 4.17e-01 | 6.26e-01 | 1.55e-01 | 2.59e-01 |
| CTLA4 inhibitory signaling | 17 | 8.07e-01 | 8.44e-01 | 0.1840 | -0.002820 | -0.027600 | 0.144000 | 0.112000 | 9.84e-01 | 8.44e-01 | 3.04e-01 | 4.25e-01 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 30 | 4.16e-01 | 5.00e-01 | 0.1840 | 0.007940 | 0.162000 | -0.026400 | 0.084600 | 9.40e-01 | 1.26e-01 | 8.02e-01 | 4.23e-01 |
| Synthesis of glycosylphosphatidylinositol (GPI) | 15 | 6.74e-01 | 7.37e-01 | 0.1840 | -0.072900 | 0.131000 | -0.048700 | 0.095400 | 6.25e-01 | 3.80e-01 | 7.44e-01 | 5.22e-01 |
| Glutathione synthesis and recycling | 10 | 7.77e-01 | 8.22e-01 | 0.1830 | -0.087900 | -0.061500 | 0.113000 | -0.096300 | 6.30e-01 | 7.36e-01 | 5.36e-01 | 5.98e-01 |
| Golgi-to-ER retrograde transport | 89 | 2.07e-01 | 2.83e-01 | 0.1830 | 0.038300 | 0.099400 | 0.105000 | 0.104000 | 5.34e-01 | 1.06e-01 | 8.62e-02 | 8.95e-02 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 23 | 6.97e-01 | 7.56e-01 | 0.1830 | -0.017200 | 0.046300 | 0.164000 | 0.063400 | 8.86e-01 | 7.01e-01 | 1.74e-01 | 5.99e-01 |
| Signaling by the B Cell Receptor (BCR) | 85 | 1.19e-02 | 2.72e-02 | 0.1820 | -0.102000 | 0.001340 | 0.151000 | 0.001180 | 1.05e-01 | 9.83e-01 | 1.63e-02 | 9.85e-01 |
| TBC/RABGAPs | 39 | 2.00e-01 | 2.75e-01 | 0.1820 | -0.074200 | 0.057000 | 0.123000 | -0.096200 | 4.23e-01 | 5.38e-01 | 1.83e-01 | 2.99e-01 |
| MAPK6/MAPK4 signaling | 73 | 3.48e-02 | 6.79e-02 | 0.1820 | -0.103000 | 0.034800 | 0.146000 | -0.009410 | 1.29e-01 | 6.08e-01 | 3.17e-02 | 8.90e-01 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 12 | 8.90e-01 | 9.13e-01 | 0.1810 | -0.026500 | 0.032000 | 0.151000 | 0.090600 | 8.74e-01 | 8.48e-01 | 3.64e-01 | 5.87e-01 |
| Disease | 1011 | 2.13e-11 | 3.80e-10 | 0.1810 | 0.058400 | 0.007850 | 0.134000 | 0.107000 | 2.21e-03 | 6.81e-01 | 2.51e-12 | 1.85e-08 |
| CD28 co-stimulation | 25 | 8.18e-01 | 8.54e-01 | 0.1810 | 0.094600 | -0.060000 | 0.077600 | 0.119000 | 4.13e-01 | 6.04e-01 | 5.02e-01 | 3.03e-01 |
| Post-translational modification: synthesis of GPI-anchored proteins | 35 | 3.19e-01 | 4.03e-01 | 0.1800 | 0.152000 | 0.041500 | -0.061300 | 0.062100 | 1.21e-01 | 6.71e-01 | 5.31e-01 | 5.26e-01 |
| Toll-like Receptor Cascades | 115 | 9.43e-02 | 1.50e-01 | 0.1800 | 0.063000 | -0.029300 | 0.141000 | 0.086700 | 2.45e-01 | 5.88e-01 | 8.99e-03 | 1.09e-01 |
| Metabolism | 1363 | 2.20e-16 | 9.65e-15 | 0.1780 | -0.071400 | -0.113000 | -0.091000 | -0.073600 | 2.00e-05 | 1.40e-11 | 5.59e-08 | 1.11e-05 |
| Transport to the Golgi and subsequent modification | 136 | 1.40e-02 | 3.08e-02 | 0.1770 | -0.025700 | 0.066900 | 0.086000 | 0.137000 | 6.06e-01 | 1.79e-01 | 8.44e-02 | 5.93e-03 |
| RNA Polymerase II Transcription | 883 | 1.17e-15 | 4.66e-14 | 0.1760 | -0.067700 | 0.140000 | 0.064700 | -0.051600 | 8.47e-04 | 5.38e-12 | 1.44e-03 | 1.10e-02 |
| Class I MHC mediated antigen processing & presentation | 302 | 6.46e-06 | 4.09e-05 | 0.1760 | -0.164000 | 0.032000 | 0.024700 | -0.048600 | 1.13e-06 | 3.42e-01 | 4.65e-01 | 1.49e-01 |
| MAP kinase activation | 59 | 1.55e-01 | 2.23e-01 | 0.1760 | -0.105000 | -0.091100 | 0.023400 | -0.104000 | 1.62e-01 | 2.27e-01 | 7.56e-01 | 1.66e-01 |
| Signaling by FGFR3 in disease | 14 | 8.59e-01 | 8.89e-01 | 0.1740 | -0.147000 | 0.050300 | 0.033900 | -0.069700 | 3.40e-01 | 7.45e-01 | 8.26e-01 | 6.52e-01 |
| Signaling by FGFR3 point mutants in cancer | 14 | 8.59e-01 | 8.89e-01 | 0.1740 | -0.147000 | 0.050300 | 0.033900 | -0.069700 | 3.40e-01 | 7.45e-01 | 8.26e-01 | 6.52e-01 |
| Regulation of PLK1 Activity at G2/M Transition | 74 | 9.22e-02 | 1.47e-01 | 0.1740 | -0.043500 | 0.126000 | 0.024300 | 0.109000 | 5.19e-01 | 6.13e-02 | 7.18e-01 | 1.06e-01 |
| Costimulation by the CD28 family | 39 | 6.26e-01 | 6.98e-01 | 0.1730 | 0.032500 | -0.009130 | 0.140000 | 0.095700 | 7.25e-01 | 9.22e-01 | 1.31e-01 | 3.02e-01 |
| IRS-mediated signalling | 27 | 6.29e-01 | 6.98e-01 | 0.1730 | -0.157000 | 0.031700 | 0.028600 | -0.057500 | 1.58e-01 | 7.76e-01 | 7.97e-01 | 6.05e-01 |
| Cleavage of the damaged pyrimidine | 14 | 9.02e-01 | 9.19e-01 | 0.1720 | 0.101000 | 0.054100 | 0.026900 | 0.125000 | 5.11e-01 | 7.26e-01 | 8.62e-01 | 4.17e-01 |
| Depyrimidination | 14 | 9.02e-01 | 9.19e-01 | 0.1720 | 0.101000 | 0.054100 | 0.026900 | 0.125000 | 5.11e-01 | 7.26e-01 | 8.62e-01 | 4.17e-01 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 14 | 9.02e-01 | 9.19e-01 | 0.1720 | 0.101000 | 0.054100 | 0.026900 | 0.125000 | 5.11e-01 | 7.26e-01 | 8.62e-01 | 4.17e-01 |
| Downstream signaling of activated FGFR3 | 17 | 7.87e-01 | 8.28e-01 | 0.1720 | -0.104000 | 0.093600 | 0.083800 | -0.054200 | 4.58e-01 | 5.04e-01 | 5.50e-01 | 6.99e-01 |
| Depolymerisation of the Nuclear Lamina | 13 | 8.75e-01 | 9.01e-01 | 0.1720 | 0.038200 | 0.091700 | 0.140000 | -0.002110 | 8.12e-01 | 5.67e-01 | 3.83e-01 | 9.89e-01 |
| FRS-mediated FGFR2 signaling | 12 | 8.66e-01 | 8.94e-01 | 0.1720 | 0.036300 | -0.058100 | 0.155000 | 0.025200 | 8.28e-01 | 7.28e-01 | 3.52e-01 | 8.80e-01 |
| SUMOylation of DNA methylation proteins | 15 | 7.67e-01 | 8.16e-01 | 0.1710 | 0.084900 | 0.105000 | 0.093400 | -0.049200 | 5.69e-01 | 4.81e-01 | 5.32e-01 | 7.42e-01 |
| TCF dependent signaling in response to WNT | 134 | 2.20e-03 | 6.61e-03 | 0.1700 | -0.107000 | 0.032700 | 0.096900 | -0.084700 | 3.32e-02 | 5.15e-01 | 5.36e-02 | 9.16e-02 |
| Recruitment of NuMA to mitotic centrosomes | 70 | 5.61e-02 | 9.97e-02 | 0.1700 | 0.013300 | 0.075600 | -0.023600 | 0.150000 | 8.48e-01 | 2.75e-01 | 7.34e-01 | 3.00e-02 |
| ESR-mediated signaling | 126 | 4.16e-02 | 7.82e-02 | 0.1690 | -0.011900 | 0.148000 | 0.080900 | 0.000338 | 8.19e-01 | 4.22e-03 | 1.18e-01 | 9.95e-01 |
| Signaling by Erythropoietin | 19 | 7.67e-01 | 8.16e-01 | 0.1690 | -0.111000 | -0.085100 | 0.010200 | -0.094400 | 4.05e-01 | 5.21e-01 | 9.38e-01 | 4.77e-01 |
| PTEN Regulation | 127 | 9.07e-03 | 2.18e-02 | 0.1680 | -0.070800 | 0.084400 | 0.123000 | -0.034200 | 1.69e-01 | 1.02e-01 | 1.74e-02 | 5.07e-01 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 148 | 1.78e-02 | 3.80e-02 | 0.1670 | -0.045500 | 0.130000 | 0.057200 | 0.075200 | 3.41e-01 | 6.68e-03 | 2.32e-01 | 1.15e-01 |
| RUNX3 regulates NOTCH signaling | 13 | 9.49e-01 | 9.53e-01 | 0.1660 | 0.027300 | 0.080800 | 0.110000 | 0.091000 | 8.65e-01 | 6.14e-01 | 4.92e-01 | 5.70e-01 |
| Cellular Senescence | 117 | 2.00e-01 | 2.75e-01 | 0.1660 | 0.073200 | 0.075200 | 0.104000 | 0.074600 | 1.72e-01 | 1.61e-01 | 5.16e-02 | 1.64e-01 |
| Centrosome maturation | 71 | 7.94e-02 | 1.31e-01 | 0.1650 | 0.010600 | 0.092000 | -0.018900 | 0.135000 | 8.77e-01 | 1.81e-01 | 7.84e-01 | 4.99e-02 |
| Recruitment of mitotic centrosome proteins and complexes | 71 | 7.94e-02 | 1.31e-01 | 0.1650 | 0.010600 | 0.092000 | -0.018900 | 0.135000 | 8.77e-01 | 1.81e-01 | 7.84e-01 | 4.99e-02 |
| Pre-NOTCH Expression and Processing | 45 | 6.29e-01 | 6.98e-01 | 0.1640 | 0.085100 | -0.089900 | 0.063900 | 0.087200 | 3.24e-01 | 2.97e-01 | 4.59e-01 | 3.12e-01 |
| Transcriptional Regulation by TP53 | 304 | 1.26e-04 | 5.65e-04 | 0.1630 | -0.059000 | 0.128000 | 0.081400 | -0.008030 | 7.90e-02 | 1.38e-04 | 1.54e-02 | 8.11e-01 |
| Transport of small molecules | 406 | 4.07e-07 | 3.57e-06 | 0.1630 | 0.005860 | -0.136000 | -0.072700 | 0.051500 | 8.41e-01 | 3.24e-06 | 1.28e-02 | 7.79e-02 |
| Interleukin-17 signaling | 61 | 1.62e-01 | 2.31e-01 | 0.1610 | -0.094600 | -0.098800 | 0.041100 | -0.074800 | 2.02e-01 | 1.83e-01 | 5.79e-01 | 3.13e-01 |
| Metabolism of nucleotides | 74 | 2.64e-01 | 3.45e-01 | 0.1580 | 0.026600 | -0.151000 | -0.035500 | 0.013400 | 6.93e-01 | 2.49e-02 | 5.98e-01 | 8.43e-01 |
| Organelle biogenesis and maintenance | 224 | 4.20e-04 | 1.61e-03 | 0.1580 | -0.051700 | 0.060000 | -0.136000 | -0.009180 | 1.85e-01 | 1.24e-01 | 4.83e-04 | 8.14e-01 |
| RET signaling | 28 | 6.85e-01 | 7.47e-01 | 0.1570 | 0.070700 | -0.137000 | 0.016900 | -0.025200 | 5.18e-01 | 2.09e-01 | 8.77e-01 | 8.17e-01 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 36 | 2.87e-01 | 3.69e-01 | 0.1570 | 0.066500 | 0.060600 | 0.070000 | -0.108000 | 4.90e-01 | 5.30e-01 | 4.68e-01 | 2.61e-01 |
| Aggrephagy | 16 | 8.24e-01 | 8.58e-01 | 0.1560 | -0.086100 | 0.047100 | 0.121000 | 0.015900 | 5.51e-01 | 7.44e-01 | 4.04e-01 | 9.12e-01 |
| Synthesis of PIPs at the plasma membrane | 44 | 4.76e-01 | 5.57e-01 | 0.1560 | 0.032700 | 0.096000 | 0.014900 | 0.118000 | 7.08e-01 | 2.71e-01 | 8.64e-01 | 1.76e-01 |
| RAF/MAP kinase cascade | 188 | 1.09e-04 | 4.92e-04 | 0.1560 | 0.028600 | -0.069100 | 0.130000 | -0.044400 | 5.01e-01 | 1.04e-01 | 2.30e-03 | 2.96e-01 |
| MAPK1/MAPK3 signaling | 193 | 1.48e-04 | 6.48e-04 | 0.1550 | 0.030800 | -0.071300 | 0.130000 | -0.034500 | 4.63e-01 | 8.91e-02 | 1.96e-03 | 4.11e-01 |
| RA biosynthesis pathway | 11 | 9.01e-01 | 9.19e-01 | 0.1550 | -0.037400 | -0.068100 | 0.061200 | 0.119000 | 8.30e-01 | 6.96e-01 | 7.25e-01 | 4.95e-01 |
| RMTs methylate histone arginines | 28 | 5.72e-01 | 6.50e-01 | 0.1550 | -0.079300 | -0.103000 | 0.048200 | -0.068800 | 4.68e-01 | 3.48e-01 | 6.59e-01 | 5.29e-01 |
| Toll Like Receptor 4 (TLR4) Cascade | 102 | 7.17e-02 | 1.21e-01 | 0.1530 | 0.039100 | -0.046400 | 0.139000 | 0.016200 | 4.97e-01 | 4.20e-01 | 1.54e-02 | 7.78e-01 |
| Signaling by ERBB2 ECD mutants | 15 | 7.74e-01 | 8.20e-01 | 0.1530 | -0.121000 | -0.054500 | 0.025200 | 0.071100 | 4.18e-01 | 7.15e-01 | 8.66e-01 | 6.34e-01 |
| ER to Golgi Anterograde Transport | 114 | 4.67e-02 | 8.61e-02 | 0.1520 | -0.092400 | 0.091000 | 0.041400 | 0.068000 | 8.91e-02 | 9.41e-02 | 4.47e-01 | 2.11e-01 |
| MyD88-independent TLR4 cascade | 83 | 4.31e-02 | 8.04e-02 | 0.1520 | -0.041100 | -0.070200 | 0.126000 | -0.023000 | 5.18e-01 | 2.70e-01 | 4.73e-02 | 7.18e-01 |
| TRIF(TICAM1)-mediated TLR4 signaling | 83 | 4.31e-02 | 8.04e-02 | 0.1520 | -0.041100 | -0.070200 | 0.126000 | -0.023000 | 5.18e-01 | 2.70e-01 | 4.73e-02 | 7.18e-01 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 31 | 7.07e-01 | 7.65e-01 | 0.1510 | -0.004840 | -0.125000 | -0.024700 | -0.081300 | 9.63e-01 | 2.29e-01 | 8.12e-01 | 4.34e-01 |
| SARS-CoV-1 Infection | 40 | 4.49e-01 | 5.33e-01 | 0.1510 | -0.062000 | -0.021600 | 0.085300 | 0.105000 | 4.98e-01 | 8.14e-01 | 3.51e-01 | 2.50e-01 |
| Signaling by FGFR in disease | 47 | 4.72e-01 | 5.55e-01 | 0.1500 | -0.101000 | 0.079500 | 0.071100 | -0.027500 | 2.31e-01 | 3.46e-01 | 3.99e-01 | 7.45e-01 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 17 | 8.91e-01 | 9.13e-01 | 0.1480 | -0.050000 | 0.076900 | 0.087800 | 0.076500 | 7.21e-01 | 5.83e-01 | 5.31e-01 | 5.85e-01 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | 17 | 8.91e-01 | 9.13e-01 | 0.1480 | -0.050000 | 0.076900 | 0.087800 | 0.076500 | 7.21e-01 | 5.83e-01 | 5.31e-01 | 5.85e-01 |
| Hedgehog 'on' state | 71 | 1.84e-01 | 2.56e-01 | 0.1480 | -0.001990 | 0.048400 | 0.138000 | -0.018200 | 9.77e-01 | 4.81e-01 | 4.40e-02 | 7.92e-01 |
| TNF signaling | 34 | 5.59e-01 | 6.37e-01 | 0.1480 | -0.036600 | -0.123000 | -0.000790 | 0.073900 | 7.12e-01 | 2.16e-01 | 9.94e-01 | 4.56e-01 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 19 | 8.68e-01 | 8.95e-01 | 0.1480 | -0.009410 | -0.101000 | -0.030800 | -0.103000 | 9.43e-01 | 4.46e-01 | 8.16e-01 | 4.39e-01 |
| PI3K/AKT Signaling in Cancer | 65 | 3.11e-01 | 3.93e-01 | 0.1470 | 0.047700 | -0.133000 | 0.033200 | -0.019800 | 5.07e-01 | 6.39e-02 | 6.44e-01 | 7.83e-01 |
| Transcriptional regulation by RUNX2 | 99 | 1.82e-01 | 2.55e-01 | 0.1460 | 0.012300 | -0.002200 | 0.138000 | 0.047100 | 8.33e-01 | 9.70e-01 | 1.80e-02 | 4.20e-01 |
| Synthesis of PC | 21 | 9.02e-01 | 9.19e-01 | 0.1450 | 0.004070 | -0.095300 | -0.096000 | -0.053200 | 9.74e-01 | 4.50e-01 | 4.47e-01 | 6.73e-01 |
| Oncogenic MAPK signaling | 68 | 2.51e-01 | 3.33e-01 | 0.1440 | 0.036200 | -0.110000 | 0.085200 | -0.001470 | 6.06e-01 | 1.16e-01 | 2.25e-01 | 9.83e-01 |
| IRS-related events triggered by IGF1R | 29 | 7.13e-01 | 7.70e-01 | 0.1420 | -0.139000 | 0.001660 | 0.018300 | -0.023500 | 1.95e-01 | 9.88e-01 | 8.65e-01 | 8.27e-01 |
| Transcriptional regulation by RUNX1 | 139 | 6.78e-02 | 1.15e-01 | 0.1420 | -0.015600 | 0.082300 | 0.114000 | 0.002200 | 7.51e-01 | 9.51e-02 | 2.04e-02 | 9.64e-01 |
| Base-Excision Repair, AP Site Formation | 16 | 9.20e-01 | 9.34e-01 | 0.1410 | 0.099000 | 0.031500 | -0.000309 | 0.095500 | 4.93e-01 | 8.27e-01 | 9.98e-01 | 5.09e-01 |
| FLT3 Signaling | 199 | 2.29e-04 | 9.31e-04 | 0.1410 | 0.005000 | -0.068300 | 0.109000 | -0.057800 | 9.04e-01 | 9.84e-02 | 8.39e-03 | 1.62e-01 |
| Signaling by FGFR4 | 29 | 7.68e-01 | 8.16e-01 | 0.1400 | 0.060800 | 0.040800 | 0.120000 | 0.004900 | 5.71e-01 | 7.04e-01 | 2.65e-01 | 9.64e-01 |
| Phase II - Conjugation of compounds | 46 | 7.16e-01 | 7.72e-01 | 0.1400 | -0.038100 | -0.067000 | -0.111000 | -0.037500 | 6.55e-01 | 4.32e-01 | 1.93e-01 | 6.61e-01 |
| Metabolism of steroids | 93 | 2.66e-01 | 3.47e-01 | 0.1400 | -0.091200 | -0.071200 | -0.011600 | -0.077300 | 1.30e-01 | 2.37e-01 | 8.47e-01 | 1.99e-01 |
| Toll Like Receptor 3 (TLR3) Cascade | 82 | 8.31e-02 | 1.36e-01 | 0.1390 | -0.042400 | -0.071300 | 0.109000 | -0.024900 | 5.08e-01 | 2.65e-01 | 8.79e-02 | 6.97e-01 |
| MAPK family signaling cascades | 224 | 5.87e-04 | 2.11e-03 | 0.1380 | 0.037300 | -0.066300 | 0.113000 | -0.023900 | 3.39e-01 | 8.89e-02 | 3.75e-03 | 5.41e-01 |
| PIP3 activates AKT signaling | 211 | 4.77e-03 | 1.29e-02 | 0.1370 | -0.008250 | 0.045900 | 0.129000 | -0.008350 | 8.37e-01 | 2.53e-01 | 1.34e-03 | 8.35e-01 |
| Insulin receptor signalling cascade | 32 | 6.91e-01 | 7.51e-01 | 0.1360 | -0.120000 | 0.038000 | 0.050000 | -0.001800 | 2.40e-01 | 7.10e-01 | 6.25e-01 | 9.86e-01 |
| Transcriptional Regulation by VENTX | 34 | 5.34e-01 | 6.13e-01 | 0.1350 | 0.050900 | 0.072600 | -0.068000 | 0.074900 | 6.07e-01 | 4.64e-01 | 4.93e-01 | 4.50e-01 |
| Oxidative Stress Induced Senescence | 59 | 4.59e-01 | 5.43e-01 | 0.1340 | 0.062300 | 0.069200 | 0.095900 | -0.010600 | 4.09e-01 | 3.59e-01 | 2.03e-01 | 8.88e-01 |
| Signaling by ERBB2 in Cancer | 18 | 9.28e-01 | 9.42e-01 | 0.1340 | -0.003380 | -0.011300 | 0.101000 | 0.087100 | 9.80e-01 | 9.34e-01 | 4.59e-01 | 5.23e-01 |
| Gastrin-CREB signalling pathway via PKC and MAPK | 15 | 9.39e-01 | 9.48e-01 | 0.1340 | 0.109000 | 0.000310 | 0.076100 | 0.012900 | 4.64e-01 | 9.98e-01 | 6.10e-01 | 9.31e-01 |
| Phospholipid metabolism | 147 | 1.63e-02 | 3.50e-02 | 0.1340 | 0.049500 | -0.039600 | -0.074500 | 0.091100 | 3.02e-01 | 4.09e-01 | 1.20e-01 | 5.76e-02 |
| HDACs deacetylate histones | 30 | 7.95e-01 | 8.36e-01 | 0.1330 | -0.034600 | 0.094700 | 0.006780 | -0.086500 | 7.43e-01 | 3.70e-01 | 9.49e-01 | 4.12e-01 |
| Cargo recognition for clathrin-mediated endocytosis | 72 | 5.21e-01 | 6.02e-01 | 0.1320 | 0.028100 | 0.111000 | 0.063400 | 0.022700 | 6.81e-01 | 1.05e-01 | 3.53e-01 | 7.39e-01 |
| Signaling by NTRK2 (TRKB) | 21 | 9.47e-01 | 9.53e-01 | 0.1320 | 0.034100 | 0.010200 | 0.073200 | 0.104000 | 7.87e-01 | 9.36e-01 | 5.62e-01 | 4.11e-01 |
| Constitutive Signaling by EGFRvIII | 15 | 8.78e-01 | 9.02e-01 | 0.1290 | -0.070900 | 0.036300 | 0.019000 | 0.099500 | 6.35e-01 | 8.08e-01 | 8.99e-01 | 5.05e-01 |
| Signaling by EGFRvIII in Cancer | 15 | 8.78e-01 | 9.02e-01 | 0.1290 | -0.070900 | 0.036300 | 0.019000 | 0.099500 | 6.35e-01 | 8.08e-01 | 8.99e-01 | 5.05e-01 |
| Metabolism of proteins | 1396 | 4.95e-13 | 1.27e-11 | 0.1280 | -0.074200 | 0.080700 | 0.064300 | 0.015600 | 7.77e-06 | 1.15e-06 | 1.06e-04 | 3.46e-01 |
| NOTCH4 Intracellular Domain Regulates Transcription | 15 | 9.62e-01 | 9.65e-01 | 0.1280 | 0.008660 | 0.002240 | 0.108000 | 0.068400 | 9.54e-01 | 9.88e-01 | 4.70e-01 | 6.46e-01 |
| Regulation of beta-cell development | 17 | 8.78e-01 | 9.02e-01 | 0.1240 | -0.068600 | -0.086600 | 0.044600 | 0.033300 | 6.24e-01 | 5.37e-01 | 7.51e-01 | 8.12e-01 |
| IGF1R signaling cascade | 30 | 7.70e-01 | 8.17e-01 | 0.1230 | -0.112000 | 0.028500 | 0.040600 | 0.010300 | 2.88e-01 | 7.87e-01 | 7.01e-01 | 9.22e-01 |
| Generic Transcription Pathway | 775 | 1.42e-06 | 1.06e-05 | 0.1220 | -0.050700 | 0.093100 | 0.034900 | -0.050300 | 1.87e-02 | 1.56e-05 | 1.06e-01 | 1.96e-02 |
| COPI-mediated anterograde transport | 73 | 3.57e-01 | 4.43e-01 | 0.1200 | -0.050500 | 0.028000 | 0.039800 | 0.097100 | 4.56e-01 | 6.80e-01 | 5.57e-01 | 1.52e-01 |
| NOTCH1 Intracellular Domain Regulates Transcription | 42 | 5.56e-01 | 6.35e-01 | 0.1200 | -0.078200 | -0.042300 | 0.077800 | -0.018800 | 3.81e-01 | 6.36e-01 | 3.84e-01 | 8.33e-01 |
| MyD88 dependent cascade initiated on endosome | 77 | 2.62e-01 | 3.44e-01 | 0.1140 | -0.004450 | -0.047600 | 0.099000 | -0.029200 | 9.46e-01 | 4.71e-01 | 1.34e-01 | 6.59e-01 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 77 | 2.62e-01 | 3.44e-01 | 0.1140 | -0.004450 | -0.047600 | 0.099000 | -0.029200 | 9.46e-01 | 4.71e-01 | 1.34e-01 | 6.59e-01 |
| Vesicle-mediated transport | 506 | 7.89e-04 | 2.76e-03 | 0.1140 | -0.002220 | 0.059700 | 0.034800 | 0.090200 | 9.33e-01 | 2.32e-02 | 1.85e-01 | 6.06e-04 |
| Signaling by ERBB4 | 37 | 7.99e-01 | 8.38e-01 | 0.1130 | 0.096700 | 0.011200 | -0.022100 | 0.053400 | 3.09e-01 | 9.06e-01 | 8.16e-01 | 5.74e-01 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 76 | 2.76e-01 | 3.57e-01 | 0.1110 | -0.017500 | -0.050900 | 0.090100 | -0.036200 | 7.93e-01 | 4.44e-01 | 1.75e-01 | 5.86e-01 |
| MyD88 cascade initiated on plasma membrane | 75 | 3.00e-01 | 3.83e-01 | 0.1110 | -0.027600 | -0.067200 | 0.070100 | -0.045900 | 6.80e-01 | 3.15e-01 | 2.95e-01 | 4.93e-01 |
| Toll Like Receptor 10 (TLR10) Cascade | 75 | 3.00e-01 | 3.83e-01 | 0.1110 | -0.027600 | -0.067200 | 0.070100 | -0.045900 | 6.80e-01 | 3.15e-01 | 2.95e-01 | 4.93e-01 |
| Toll Like Receptor 5 (TLR5) Cascade | 75 | 3.00e-01 | 3.83e-01 | 0.1110 | -0.027600 | -0.067200 | 0.070100 | -0.045900 | 6.80e-01 | 3.15e-01 | 2.95e-01 | 4.93e-01 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 31 | 8.17e-01 | 8.54e-01 | 0.1110 | -0.076800 | 0.026900 | 0.062400 | 0.042200 | 4.60e-01 | 7.96e-01 | 5.48e-01 | 6.85e-01 |
| Membrane Trafficking | 484 | 7.76e-04 | 2.73e-03 | 0.1090 | -0.031000 | 0.069200 | 0.028500 | 0.072800 | 2.48e-01 | 1.00e-02 | 2.89e-01 | 6.76e-03 |
| FRS-mediated FGFR1 signaling | 12 | 9.38e-01 | 9.48e-01 | 0.1060 | 0.054300 | 0.003670 | 0.060900 | -0.067200 | 7.45e-01 | 9.82e-01 | 7.15e-01 | 6.87e-01 |
| Signaling by NOTCH | 148 | 2.65e-01 | 3.46e-01 | 0.1040 | 0.007420 | -0.060700 | 0.074400 | 0.039300 | 8.77e-01 | 2.04e-01 | 1.19e-01 | 4.11e-01 |
| Signaling by ERBB2 KD Mutants | 17 | 9.39e-01 | 9.48e-01 | 0.1040 | -0.040400 | -0.061300 | 0.050700 | 0.052800 | 7.73e-01 | 6.62e-01 | 7.18e-01 | 7.06e-01 |
| NOD1/2 Signaling Pathway | 27 | 8.97e-01 | 9.18e-01 | 0.1030 | -0.011700 | -0.097200 | 0.031000 | 0.000116 | 9.16e-01 | 3.82e-01 | 7.81e-01 | 9.99e-01 |
| Post-translational protein modification | 996 | 4.14e-05 | 2.04e-04 | 0.1010 | -0.026200 | 0.061500 | 0.061200 | 0.045300 | 1.73e-01 | 1.38e-03 | 1.45e-03 | 1.85e-02 |
| Intracellular signaling by second messengers | 243 | 3.97e-02 | 7.51e-02 | 0.0998 | 0.013400 | -0.011000 | 0.098200 | -0.003550 | 7.21e-01 | 7.70e-01 | 8.76e-03 | 9.25e-01 |
| Toll Like Receptor 9 (TLR9) Cascade | 80 | 3.92e-01 | 4.74e-01 | 0.0987 | -0.032200 | -0.023200 | 0.087200 | -0.023500 | 6.20e-01 | 7.21e-01 | 1.78e-01 | 7.17e-01 |
| Signaling by NOTCH1 | 62 | 8.86e-01 | 9.10e-01 | 0.0983 | 0.060900 | -0.037500 | 0.034700 | 0.057800 | 4.08e-01 | 6.11e-01 | 6.37e-01 | 4.32e-01 |
| Downstream signaling of activated FGFR1 | 19 | 9.42e-01 | 9.48e-01 | 0.0977 | -0.004830 | 0.035800 | 0.088000 | -0.022200 | 9.71e-01 | 7.87e-01 | 5.07e-01 | 8.67e-01 |
| Metabolism of lipids | 489 | 8.64e-03 | 2.09e-02 | 0.0957 | -0.018200 | -0.066400 | -0.066100 | 0.007150 | 4.97e-01 | 1.30e-02 | 1.35e-02 | 7.89e-01 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 81 | 4.21e-01 | 5.04e-01 | 0.0954 | 0.009180 | -0.054600 | 0.069900 | -0.034000 | 8.87e-01 | 3.97e-01 | 2.78e-01 | 5.98e-01 |
| Toll Like Receptor 2 (TLR2) Cascade | 81 | 4.21e-01 | 5.04e-01 | 0.0954 | 0.009180 | -0.054600 | 0.069900 | -0.034000 | 8.87e-01 | 3.97e-01 | 2.78e-01 | 5.98e-01 |
| Toll Like Receptor TLR1:TLR2 Cascade | 81 | 4.21e-01 | 5.04e-01 | 0.0954 | 0.009180 | -0.054600 | 0.069900 | -0.034000 | 8.87e-01 | 3.97e-01 | 2.78e-01 | 5.98e-01 |
| Toll Like Receptor TLR6:TLR2 Cascade | 81 | 4.21e-01 | 5.04e-01 | 0.0954 | 0.009180 | -0.054600 | 0.069900 | -0.034000 | 8.87e-01 | 3.97e-01 | 2.78e-01 | 5.98e-01 |
| Adaptive Immune System | 476 | 1.06e-02 | 2.49e-02 | 0.0935 | -0.034600 | 0.025200 | 0.068800 | 0.046800 | 2.02e-01 | 3.53e-01 | 1.11e-02 | 8.40e-02 |
| Deactivation of the beta-catenin transactivating complex | 32 | 9.50e-01 | 9.54e-01 | 0.0933 | 0.018600 | -0.044600 | 0.047000 | 0.064500 | 8.56e-01 | 6.63e-01 | 6.46e-01 | 5.28e-01 |
| Diseases of signal transduction by growth factor receptors and second messengers | 304 | 1.87e-02 | 3.95e-02 | 0.0887 | -0.034600 | -0.025900 | 0.077000 | -0.008660 | 3.04e-01 | 4.40e-01 | 2.20e-02 | 7.97e-01 |
| Hedgehog 'off' state | 87 | 5.23e-01 | 6.04e-01 | 0.0878 | -0.031300 | 0.020300 | 0.072100 | -0.033500 | 6.14e-01 | 7.44e-01 | 2.46e-01 | 5.90e-01 |
| Beta-catenin independent WNT signaling | 117 | 6.20e-01 | 6.95e-01 | 0.0877 | 0.038700 | -0.008010 | 0.076900 | 0.015000 | 4.71e-01 | 8.81e-01 | 1.52e-01 | 7.80e-01 |
| FRS-mediated FGFR4 signaling | 12 | 9.89e-01 | 9.91e-01 | 0.0876 | 0.016500 | -0.056000 | 0.061600 | 0.021700 | 9.21e-01 | 7.37e-01 | 7.12e-01 | 8.96e-01 |
| Downstream signaling of activated FGFR2 | 17 | 9.66e-01 | 9.69e-01 | 0.0830 | -0.047900 | -0.008300 | 0.067000 | -0.006740 | 7.33e-01 | 9.53e-01 | 6.33e-01 | 9.62e-01 |
| Signaling by WNT | 202 | 2.27e-01 | 3.07e-01 | 0.0784 | -0.042400 | 0.014900 | 0.057100 | -0.029400 | 3.01e-01 | 7.17e-01 | 1.64e-01 | 4.73e-01 |
| Signaling by Hedgehog | 114 | 7.17e-01 | 7.72e-01 | 0.0765 | 0.041500 | 0.004510 | 0.063900 | 0.004820 | 4.45e-01 | 9.34e-01 | 2.40e-01 | 9.29e-01 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 50 | 9.41e-01 | 9.48e-01 | 0.0741 | 0.030200 | -0.067500 | -0.005640 | 0.000637 | 7.13e-01 | 4.10e-01 | 9.45e-01 | 9.94e-01 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | 50 | 9.41e-01 | 9.48e-01 | 0.0741 | 0.030200 | -0.067500 | -0.005640 | 0.000637 | 7.13e-01 | 4.10e-01 | 9.45e-01 | 9.94e-01 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 50 | 9.41e-01 | 9.48e-01 | 0.0741 | 0.030200 | -0.067500 | -0.005640 | 0.000637 | 7.13e-01 | 4.10e-01 | 9.45e-01 | 9.94e-01 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | 50 | 9.41e-01 | 9.48e-01 | 0.0741 | 0.030200 | -0.067500 | -0.005640 | 0.000637 | 7.13e-01 | 4.10e-01 | 9.45e-01 | 9.94e-01 |
| Signaling by NOTCH1 in Cancer | 50 | 9.41e-01 | 9.48e-01 | 0.0741 | 0.030200 | -0.067500 | -0.005640 | 0.000637 | 7.13e-01 | 4.10e-01 | 9.45e-01 | 9.94e-01 |
| Signaling by Nuclear Receptors | 175 | 6.11e-01 | 6.88e-01 | 0.0707 | -0.019400 | 0.058500 | 0.022000 | -0.026700 | 6.60e-01 | 1.83e-01 | 6.17e-01 | 5.44e-01 |
| CD28 dependent PI3K/Akt signaling | 17 | 9.92e-01 | 9.93e-01 | 0.0636 | -0.021900 | -0.055200 | 0.009660 | -0.020700 | 8.76e-01 | 6.94e-01 | 9.45e-01 | 8.83e-01 |
| Downstream signaling of activated FGFR4 | 17 | 9.93e-01 | 9.93e-01 | 0.0629 | -0.061900 | -0.006840 | 0.000800 | -0.009200 | 6.59e-01 | 9.61e-01 | 9.95e-01 | 9.48e-01 |
| RAB GEFs exchange GTP for GDP on RABs | 81 | 9.16e-01 | 9.32e-01 | 0.0628 | 0.016600 | 0.034000 | 0.009840 | 0.049200 | 7.96e-01 | 5.98e-01 | 8.79e-01 | 4.45e-01 |
| Rab regulation of trafficking | 110 | 9.37e-01 | 9.48e-01 | 0.0454 | -0.032000 | 0.020700 | 0.023200 | 0.008320 | 5.64e-01 | 7.08e-01 | 6.75e-01 | 8.81e-01 |
Detailed Gene set reports
Interleukin-10 signaling
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 1.12e-06 |
| p.adjustMANOVA | 8.69e-06 |
| s.dist | 1.31 |
| s.FSHD | 0.736 |
| s.hu_model | -0.252 |
| s.Watt_m | 0.748 |
| s.Jones_m | 0.742 |
| p.FSHD | 2.34e-05 |
| p.hu_model | 0.148 |
| p.Watt_m | 1.74e-05 |
| p.Jones_m | 2.03e-05 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| TIMP1 | 5188 | 4988 |
| TNFRSF1B | 4548 | 5115 |
| STAT3 | 5013 | 4348 |
| CCL2 | 5061 | 3964 |
| ICAM1 | 4128 | 4600 |
| CSF1 | 4312 | 3814 |
| TNFRSF1A | 3322 | 4778 |
| IL1R1 | 3866 | 4015 |
| IL10RB | 3206 | 4242 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CCL2 | 4787 | 2597 | 5061 | 3964 |
| CSF1 | 4653 | -4188 | 4312 | 3814 |
| ICAM1 | 4641 | 1044 | 4128 | 4600 |
| IL10RB | 4957 | 1225 | 3206 | 4242 |
| IL1R1 | 4382 | -2979 | 3866 | 4015 |
| JAK1 | 1002 | -1843 | 4184 | -1810 |
| STAT3 | 850 | -3836 | 5013 | 4348 |
| TIMP1 | 4933 | -1301 | 5188 | 4988 |
| TNFRSF1A | 3907 | -4606 | 3322 | 4778 |
| TNFRSF1B | 4174 | -866 | 4548 | 5115 |
| TYK2 | 2357 | -3081 | -49 | 4512 |
Citric acid cycle (TCA cycle)
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 6.96e-09 |
| p.adjustMANOVA | 8.14e-08 |
| s.dist | 1.1 |
| s.FSHD | -0.669 |
| s.hu_model | -0.243 |
| s.Watt_m | -0.597 |
| s.Jones_m | -0.585 |
| p.FSHD | 1.09e-07 |
| p.hu_model | 0.0543 |
| p.Watt_m | 2.21e-06 |
| p.Jones_m | 3.42e-06 |
| Gene | FSHD | Watt_m |
|---|---|---|
| DLD | -4923 | -4683 |
| IDH3A | -5238 | -3782 |
| SUCLA2 | -4446 | -4329 |
| CS | -5372 | -3526 |
| FAHD1 | -4055 | -4256 |
| ACO2 | -3871 | -4378 |
| SUCLG2 | -3363 | -4245 |
| SDHA | -3097 | -4539 |
| SDHC | -4613 | -2969 |
| FH | -4577 | -2865 |
| DLST | -3558 | -3488 |
| SDHB | -3231 | -3667 |
| NNT | -4770 | -2350 |
| OGDH | -3051 | -3610 |
| IDH2 | -2867 | -3813 |
| IDH3B | -4107 | -2153 |
| SUCLG1 | -3825 | -2116 |
| ME3 | -2144 | -3679 |
| MDH2 | -2694 | -2826 |
| IDH3G | -896 | -3096 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACO2 | -3871 | -3773 | -4378 | -3916 |
| CS | -5372 | 3624 | -3526 | -4669 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| DLST | -3558 | -322 | -3488 | -1773 |
| FAHD1 | -4055 | -1748 | -4256 | -2464 |
| FH | -4577 | 284 | -2865 | -3264 |
| IDH2 | -2867 | -5154 | -3813 | -2755 |
| IDH3A | -5238 | -2126 | -3782 | -4519 |
| IDH3B | -4107 | -2843 | -2153 | -4270 |
| IDH3G | -896 | -4125 | -3096 | -3697 |
| MDH2 | -2694 | -4307 | -2826 | -2711 |
| ME2 | -3037 | -1766 | 3484 | 4800 |
| ME3 | -2144 | 4173 | -3679 | -5302 |
| NNT | -4770 | -3281 | -2350 | -261 |
| OGDH | -3051 | -5206 | -3610 | -3542 |
| SDHA | -3097 | -4713 | -4539 | -4393 |
| SDHB | -3231 | 427 | -3667 | -3677 |
| SDHC | -4613 | -3665 | -2969 | -3035 |
| SUCLA2 | -4446 | 1500 | -4329 | -3679 |
| SUCLG1 | -3825 | -31 | -2116 | -5153 |
| SUCLG2 | -3363 | -1153 | -4245 | -4203 |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 1.14e-05 |
| p.adjustMANOVA | 6.63e-05 |
| s.dist | 1.05 |
| s.FSHD | 0.767 |
| s.hu_model | 0.113 |
| s.Watt_m | 0.324 |
| s.Jones_m | 0.622 |
| p.FSHD | 1.66e-06 |
| p.hu_model | 0.481 |
| p.Watt_m | 0.043 |
| p.Jones_m | 0.000102 |
| Gene | FSHD | Jones_m |
|---|---|---|
| IFITM1 | 5068 | 5021 |
| ITGB2 | 4906 | 5102 |
| VCAM1 | 4924 | 4588 |
| ICAM1 | 4641 | 4600 |
| C3 | 4737 | 4049 |
| CD81 | 4123 | 4155 |
| COLEC12 | 4753 | 3221 |
| B2M | 3754 | 3232 |
| NPDC1 | 4308 | 1392 |
| ITGB1 | 891 | 4783 |
| CD34 | 3598 | 1165 |
| ITGA4 | 2431 | 1443 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| B2M | 3754 | -727 | 1576 | 3232 |
| C3 | 4737 | 4276 | 1818 | 4049 |
| CD34 | 3598 | 847 | 882 | 1165 |
| CD81 | 4123 | -4615 | 886 | 4155 |
| COLEC12 | 4753 | 4226 | 45 | 3221 |
| ICAM1 | 4641 | 1044 | 4128 | 4600 |
| ICAM2 | 1999 | -1485 | -3439 | -639 |
| IFITM1 | 5068 | 1557 | 4767 | 5021 |
| ITGA4 | 2431 | -2840 | -5085 | 1443 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB2 | 4906 | -107 | 4945 | 5102 |
| NPDC1 | 4308 | -2095 | 1815 | 1392 |
| VCAM1 | 4924 | 2842 | 4665 | 4588 |
Branched-chain amino acid catabolism
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 9.57e-07 |
| p.adjustMANOVA | 7.69e-06 |
| s.dist | 1 |
| s.FSHD | -0.612 |
| s.hu_model | -0.074 |
| s.Watt_m | -0.531 |
| s.Jones_m | -0.586 |
| p.FSHD | 2.18e-06 |
| p.hu_model | 0.567 |
| p.Watt_m | 3.92e-05 |
| p.Jones_m | 5.68e-06 |
| Gene | FSHD | Jones_m |
|---|---|---|
| ALDH6A1 | -5168 | -5042 |
| BCKDHB | -4880 | -5232 |
| MCCC2 | -4989 | -4935 |
| HIBADH | -5132 | -4793 |
| BCKDK | -4926 | -4871 |
| AUH | -4887 | -4708 |
| DBT | -4678 | -4844 |
| MCCC1 | -4819 | -4559 |
| ACADSB | -5075 | -4291 |
| BCAT2 | -3351 | -5043 |
| DLD | -4923 | -2906 |
| HIBCH | -4290 | -3311 |
| IVD | -2675 | -5071 |
| ACAT1 | -3241 | -3742 |
| SLC25A44 | -2647 | -2544 |
| ECHS1 | -1230 | -2015 |
| PPM1K | -849 | -2608 |
| ACAD8 | -3612 | -184 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACAD8 | -3612 | -1244 | -4983 | -184 |
| ACADSB | -5075 | 3061 | -4881 | -4291 |
| ACAT1 | -3241 | 466 | -1915 | -3742 |
| ALDH6A1 | -5168 | -1380 | -5181 | -5042 |
| AUH | -4887 | -1278 | -3145 | -4708 |
| BCAT1 | 3603 | -3502 | 4012 | 4365 |
| BCAT2 | -3351 | -4129 | -4904 | -5043 |
| BCKDHB | -4880 | -4187 | -2605 | -5232 |
| BCKDK | -4926 | -4633 | -3584 | -4871 |
| DBT | -4678 | 1983 | 5157 | -4844 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| ECHS1 | -1230 | -3845 | -4723 | -2015 |
| HIBADH | -5132 | -3981 | -2535 | -4793 |
| HIBCH | -4290 | 483 | -5021 | -3311 |
| HSD17B10 | -201 | -1178 | -480 | 3967 |
| IVD | -2675 | -4745 | -5058 | -5071 |
| MCCC1 | -4819 | 3980 | -4638 | -4559 |
| MCCC2 | -4989 | 2184 | -4913 | -4935 |
| PPM1K | -849 | 2258 | -5158 | -2608 |
| SLC25A44 | -2647 | 4803 | 2415 | -2544 |
Pyruvate metabolism and Citric Acid (TCA) cycle
| metric | value |
|---|---|
| setSize | 49 |
| pMANOVA | 3.58e-17 |
| p.adjustMANOVA | 1.69e-15 |
| s.dist | 0.99 |
| s.FSHD | -0.571 |
| s.hu_model | -0.263 |
| s.Watt_m | -0.559 |
| s.Jones_m | -0.522 |
| p.FSHD | 4.77e-12 |
| p.hu_model | 0.00146 |
| p.Watt_m | 1.28e-11 |
| p.Jones_m | 2.63e-10 |
| Gene | FSHD | Watt_m |
|---|---|---|
| PDP1 | -5181 | -4550 |
| DLD | -4923 | -4683 |
| IDH3A | -5238 | -3782 |
| SUCLA2 | -4446 | -4329 |
| ME1 | -4907 | -3918 |
| CS | -5372 | -3526 |
| VDAC1 | -3918 | -4553 |
| RXRA | -4228 | -4147 |
| FAHD1 | -4055 | -4256 |
| GLO1 | -4424 | -3844 |
| ACO2 | -3871 | -4378 |
| DLAT | -4452 | -3783 |
| PDK1 | -5017 | -3198 |
| L2HGDH | -4395 | -3601 |
| SLC16A3 | -3677 | -4114 |
| SUCLG2 | -3363 | -4245 |
| SDHA | -3097 | -4539 |
| SDHC | -4613 | -2969 |
| MPC1 | -4270 | -3199 |
| FH | -4577 | -2865 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACO2 | -3871 | -3773 | -4378 | -3916 |
| ADHFE1 | -5136 | -3988 | -2451 | -4869 |
| BSG | -1369 | -2217 | -2093 | -5147 |
| CS | -5372 | 3624 | -3526 | -4669 |
| D2HGDH | -1446 | -4830 | -5276 | -4528 |
| DLAT | -4452 | -1933 | -3783 | -2572 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| DLST | -3558 | -322 | -3488 | -1773 |
| FAHD1 | -4055 | -1748 | -4256 | -2464 |
| FH | -4577 | 284 | -2865 | -3264 |
| GLO1 | -4424 | -675 | -3844 | -4433 |
| GSTZ1 | -2505 | -2039 | -4578 | -3972 |
| HAGH | -2311 | -4451 | 1234 | -3032 |
| IDH2 | -2867 | -5154 | -3813 | -2755 |
| IDH3A | -5238 | -2126 | -3782 | -4519 |
| IDH3B | -4107 | -2843 | -2153 | -4270 |
| IDH3G | -896 | -4125 | -3096 | -3697 |
| L2HGDH | -4395 | -261 | -3601 | -5228 |
| LDHA | -341 | -3208 | -2881 | -3674 |
| LDHB | -1357 | -1472 | -1954 | -1554 |
| MDH2 | -2694 | -4307 | -2826 | -2711 |
| ME1 | -4907 | 1772 | -3918 | -4943 |
| ME2 | -3037 | -1766 | 3484 | 4800 |
| ME3 | -2144 | 4173 | -3679 | -5302 |
| MPC1 | -4270 | -3634 | -3199 | 4240 |
| MPC2 | -2780 | 819 | -1719 | -3784 |
| NNT | -4770 | -3281 | -2350 | -261 |
| OGDH | -3051 | -5206 | -3610 | -3542 |
| PDHA1 | -2764 | -2373 | -4403 | -777 |
| PDHB | -3237 | -133 | -3954 | -943 |
| PDHX | -2958 | -126 | -3831 | -4229 |
| PDK1 | -5017 | 4559 | -3198 | -4230 |
| PDK2 | -3728 | -5386 | -3496 | -5057 |
| PDK3 | 3897 | 4705 | 4816 | 4812 |
| PDK4 | 2105 | -708 | -5180 | -789 |
| PDP1 | -5181 | -2146 | -4550 | -4820 |
| PDP2 | -4664 | -2585 | -2415 | -2584 |
| PDPR | -614 | -629 | -4776 | 2790 |
| PPARD | -1449 | -4159 | -2316 | -2644 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
| SDHA | -3097 | -4713 | -4539 | -4393 |
| SDHB | -3231 | 427 | -3667 | -3677 |
| SDHC | -4613 | -3665 | -2969 | -3035 |
| SLC16A1 | -2731 | -975 | 5026 | 1675 |
| SLC16A3 | -3677 | -4691 | -4114 | 22 |
| SUCLA2 | -4446 | 1500 | -4329 | -3679 |
| SUCLG1 | -3825 | -31 | -2116 | -5153 |
| SUCLG2 | -3363 | -1153 | -4245 | -4203 |
| VDAC1 | -3918 | -2871 | -4553 | -5178 |
Signal regulatory protein family interactions
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.000638 |
| p.adjustMANOVA | 0.00226 |
| s.dist | 0.988 |
| s.FSHD | 0.544 |
| s.hu_model | -0.412 |
| s.Watt_m | 0.507 |
| s.Jones_m | 0.504 |
| p.FSHD | 0.00292 |
| p.hu_model | 0.0242 |
| p.Watt_m | 0.00547 |
| p.Jones_m | 0.00577 |
| Gene | FSHD | Watt_m |
|---|---|---|
| SIRPA | 5077 | 4178 |
| PTPN6 | 3645 | 4751 |
| PTK2B | 3738 | 3819 |
| FYB | 3409 | 3446 |
| GRB2 | 2101 | 4449 |
| CD47 | 3471 | 2654 |
| SRC | 5021 | 1364 |
| SKAP2 | 1349 | 3730 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CD47 | 3471 | -2154 | 2654 | 4552 |
| FYB | 3409 | -2205 | 3446 | 5133 |
| GRB2 | 2101 | -3999 | 4449 | 3 |
| PTK2 | 692 | -2465 | -1494 | -4001 |
| PTK2B | 3738 | -2429 | 3819 | 4345 |
| PTPN11 | -1703 | -1554 | -660 | -1108 |
| PTPN6 | 3645 | -920 | 4751 | 5055 |
| SIRPA | 5077 | -5563 | 4178 | 5226 |
| SKAP2 | 1349 | 511 | 3730 | 4714 |
| SRC | 5021 | -3860 | 1364 | 2269 |
Glyoxylate metabolism and glycine degradation
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 4.39e-07 |
| p.adjustMANOVA | 3.83e-06 |
| s.dist | 0.985 |
| s.FSHD | -0.669 |
| s.hu_model | -0.172 |
| s.Watt_m | -0.511 |
| s.Jones_m | -0.481 |
| p.FSHD | 2.24e-07 |
| p.hu_model | 0.183 |
| p.Watt_m | 7.56e-05 |
| p.Jones_m | 0.000198 |
| Gene | FSHD | Watt_m |
|---|---|---|
| DLD | -4923 | -4683 |
| LIAS | -4836 | -4645 |
| DHTKD1 | -5034 | -4064 |
| GRHPR | -4445 | -3989 |
| DLAT | -4452 | -3783 |
| PXMP2 | -4332 | -3793 |
| PDHB | -3237 | -3954 |
| BCKDHB | -4880 | -2605 |
| DLST | -3558 | -3488 |
| ALDH4A1 | -3609 | -3426 |
| PDHA1 | -2764 | -4403 |
| LIPT2 | -4571 | -2613 |
| PDHX | -2958 | -3831 |
| OGDH | -3051 | -3610 |
| NDUFAB1 | -3229 | -3221 |
| GOT2 | -3182 | -3058 |
| DDO | -1496 | -4307 |
| GCSH | -2911 | -1027 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ALDH4A1 | -3609 | -2272 | -3426 | -5036 |
| BCKDHB | -4880 | -4187 | -2605 | -5232 |
| DBT | -4678 | 1983 | 5157 | -4844 |
| DDO | -1496 | -3730 | -4307 | -2212 |
| DHTKD1 | -5034 | -417 | -4064 | -3053 |
| DLAT | -4452 | -1933 | -3783 | -2572 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| DLST | -3558 | -322 | -3488 | -1773 |
| GCSH | -2911 | -140 | -1027 | 3384 |
| GOT2 | -3182 | -3657 | -3058 | -2419 |
| GRHPR | -4445 | -4670 | -3989 | -5011 |
| LIAS | -4836 | -1118 | -4645 | -3638 |
| LIPT1 | -1830 | 3389 | 4611 | 3565 |
| LIPT2 | -4571 | 296 | -2613 | -2943 |
| NDUFAB1 | -3229 | 1139 | -3221 | -1911 |
| OGDH | -3051 | -5206 | -3610 | -3542 |
| PDHA1 | -2764 | -2373 | -4403 | -777 |
| PDHB | -3237 | -133 | -3954 | -943 |
| PDHX | -2958 | -126 | -3831 | -4229 |
| PXMP2 | -4332 | -1718 | -3793 | -5187 |
The NLRP3 inflammasome
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00277 |
| p.adjustMANOVA | 0.00804 |
| s.dist | 0.978 |
| s.FSHD | 0.541 |
| s.hu_model | -0.0891 |
| s.Watt_m | 0.49 |
| s.Jones_m | 0.645 |
| p.FSHD | 0.00304 |
| p.hu_model | 0.626 |
| p.Watt_m | 0.00731 |
| p.Jones_m | 0.000411 |
| Gene | Jones_m | FSHD |
|---|---|---|
| NFKB2 | 5030 | 5031 |
| PYCARD | 4818 | 4190 |
| APP | 4891 | 3990 |
| CASP1 | 4113 | 3545 |
| NFKB1 | 3086 | 4613 |
| TXN | 4226 | 3016 |
| RELA | 1891 | 3940 |
| PANX1 | 1607 | 1524 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| APP | 3990 | -2756 | 574 | 4891 |
| CASP1 | 3545 | -1282 | 3136 | 4113 |
| HSP90AB1 | -1913 | -636 | 4582 | 723 |
| NFKB1 | 4613 | -4179 | 3276 | 3086 |
| NFKB2 | 5031 | -3876 | 3297 | 5030 |
| PANX1 | 1524 | 1130 | 1051 | 1607 |
| PYCARD | 4190 | -2774 | 4656 | 4818 |
| RELA | 3940 | 1766 | 4484 | 1891 |
| SUGT1 | -1257 | 3113 | -4483 | 3225 |
| TXN | 3016 | 1838 | 4743 | 4226 |
Prolactin receptor signaling
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00391 |
| p.adjustMANOVA | 0.0109 |
| s.dist | 0.957 |
| s.FSHD | -0.469 |
| s.hu_model | -0.246 |
| s.Watt_m | -0.536 |
| s.Jones_m | -0.591 |
| p.FSHD | 0.0103 |
| p.hu_model | 0.178 |
| p.Watt_m | 0.00334 |
| p.Jones_m | 0.00122 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| STAT5B | -5297 | -5248 |
| GHR | -5231 | -4592 |
| JAK2 | -4773 | -5002 |
| SKP1 | -4257 | -2481 |
| STAT5A | -2292 | -4522 |
| BTRC | -2884 | -2731 |
| RBX1 | -4220 | -962 |
| CUL1 | -1576 | -1522 |
| PTPN11 | -1108 | -660 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| BTRC | -4959 | -1172 | -2731 | -2884 |
| CUL1 | -4085 | -3079 | -1522 | -1576 |
| GHR | -4796 | 3964 | -4592 | -5231 |
| JAK2 | -732 | -2536 | -5002 | -4773 |
| PTPN11 | -1703 | -1554 | -660 | -1108 |
| RBX1 | -1602 | -729 | -962 | -4220 |
| SH2B1 | -2444 | -3792 | -965 | 196 |
| SKP1 | -3134 | 2010 | -2481 | -4257 |
| STAT5A | 2168 | -4072 | -4522 | -2292 |
| STAT5B | -5194 | -4960 | -5248 | -5297 |
Post-chaperonin tubulin folding pathway
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 3.49e-06 |
| p.adjustMANOVA | 2.34e-05 |
| s.dist | 0.923 |
| s.FSHD | 0.315 |
| s.hu_model | -0.483 |
| s.Watt_m | 0.556 |
| s.Jones_m | 0.459 |
| p.FSHD | 0.0348 |
| p.hu_model | 0.00122 |
| p.Watt_m | 0.000194 |
| p.Jones_m | 0.0021 |
| Gene | Watt_m | hu_model |
|---|---|---|
| TUBB6 | 5153 | -4998 |
| TUBA1B | 4866 | -5262 |
| TUBA1C | 5075 | -4823 |
| TUBB2B | 4912 | -4644 |
| TUBB2A | 4401 | -4616 |
| TUBA1A | 3672 | -5166 |
| TUBA4A | 2049 | -5280 |
| TBCA | 1786 | -2549 |
| TBCE | 492 | -452 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ARL2 | 714 | -4089 | -518 | -3571 |
| TBCA | 375 | -2549 | 1786 | 3693 |
| TBCB | 4295 | 1103 | 3212 | 3467 |
| TBCC | 706 | 3004 | 4671 | 2735 |
| TBCD | 1482 | -4080 | -590 | 3505 |
| TBCE | -4318 | -452 | 492 | 781 |
| TUBA1A | 4948 | -5166 | 3672 | 3786 |
| TUBA1B | 4448 | -5262 | 4866 | 4967 |
| TUBA1C | 3088 | -4823 | 5075 | 5010 |
| TUBA4A | -2112 | -5280 | 2049 | -3253 |
| TUBA8 | -2556 | -1103 | -882 | -2976 |
| TUBB2A | 2970 | -4616 | 4401 | 4710 |
| TUBB2B | 2381 | -4644 | 4912 | 4788 |
| TUBB4B | 776 | 426 | 4848 | 2861 |
| TUBB6 | 4937 | -4998 | 5153 | 5168 |
Inflammasomes
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00105 |
| p.adjustMANOVA | 0.00354 |
| s.dist | 0.922 |
| s.FSHD | 0.476 |
| s.hu_model | -0.218 |
| s.Watt_m | 0.446 |
| s.Jones_m | 0.614 |
| p.FSHD | 0.00432 |
| p.hu_model | 0.19 |
| p.Watt_m | 0.00746 |
| p.Jones_m | 0.00023 |
| Gene | Jones_m | FSHD |
|---|---|---|
| NFKB2 | 5030 | 5031 |
| PYCARD | 4818 | 4190 |
| APP | 4891 | 3990 |
| CASP1 | 4113 | 3545 |
| NFKB1 | 3086 | 4613 |
| TXN | 4226 | 3016 |
| BCL2L1 | 1941 | 4359 |
| RELA | 1891 | 3940 |
| PANX1 | 1607 | 1524 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| APP | 3990 | -2756 | 574 | 4891 |
| BCL2 | -3161 | -4574 | -1100 | 2806 |
| BCL2L1 | 4359 | -5119 | 3393 | 1941 |
| CASP1 | 3545 | -1282 | 3136 | 4113 |
| HSP90AB1 | -1913 | -636 | 4582 | 723 |
| NFKB1 | 4613 | -4179 | 3276 | 3086 |
| NFKB2 | 5031 | -3876 | 3297 | 5030 |
| PANX1 | 1524 | 1130 | 1051 | 1607 |
| PYCARD | 4190 | -2774 | 4656 | 4818 |
| RELA | 3940 | 1766 | 4484 | 1891 |
| SUGT1 | -1257 | 3113 | -4483 | 3225 |
| TXN | 3016 | 1838 | 4743 | 4226 |
Mitochondrial tRNA aminoacylation
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 2.69e-06 |
| p.adjustMANOVA | 1.84e-05 |
| s.dist | 0.913 |
| s.FSHD | -0.609 |
| s.hu_model | 0.179 |
| s.Watt_m | -0.565 |
| s.Jones_m | -0.334 |
| p.FSHD | 7.59e-06 |
| p.hu_model | 0.189 |
| p.Watt_m | 3.36e-05 |
| p.Jones_m | 0.0142 |
| Gene | FSHD | Watt_m |
|---|---|---|
| IARS2 | -4937 | -5169 |
| SARS2 | -4125 | -4633 |
| LARS2 | -4758 | -4016 |
| DARS2 | -5377 | -3100 |
| CARS2 | -4742 | -3294 |
| NARS2 | -4447 | -3318 |
| VARS2 | -2948 | -4902 |
| HARS2 | -4878 | -2721 |
| TARS2 | -2811 | -4285 |
| FARS2 | -3653 | -2932 |
| AARS2 | -1823 | -4573 |
| MARS2 | -3770 | -2080 |
| EARS2 | -4338 | -1492 |
| YARS2 | -2279 | -2282 |
| PPA2 | -4060 | -958 |
| RARS2 | -891 | -2276 |
| PARS2 | -1167 | -205 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AARS2 | -1823 | -2636 | -4573 | -3348 |
| CARS2 | -4742 | -2732 | -3294 | -89 |
| DARS2 | -5377 | 1623 | -3100 | -2855 |
| EARS2 | -4338 | -2461 | -1492 | -3698 |
| FARS2 | -3653 | 2730 | -2932 | 707 |
| HARS2 | -4878 | 4682 | -2721 | -4375 |
| IARS2 | -4937 | 1933 | -5169 | -2267 |
| LARS2 | -4758 | 2101 | -4016 | -678 |
| MARS2 | -3770 | 4644 | -2080 | -2858 |
| NARS2 | -4447 | 2027 | -3318 | -1778 |
| PARS2 | -1167 | 2627 | -205 | -727 |
| PPA2 | -4060 | -162 | -958 | -194 |
| RARS2 | -891 | -56 | -2276 | 163 |
| SARS2 | -4125 | -3536 | -4633 | -3521 |
| TARS2 | -2811 | -523 | -4285 | -2628 |
| VARS2 | -2948 | -2605 | -4902 | -2295 |
| WARS2 | 33 | -880 | -2086 | 425 |
| YARS2 | -2279 | 4816 | -2282 | -2242 |
Complex I biogenesis
| metric | value |
|---|---|
| setSize | 52 |
| pMANOVA | 8.57e-16 |
| p.adjustMANOVA | 3.51e-14 |
| s.dist | 0.913 |
| s.FSHD | -0.551 |
| s.hu_model | -0.196 |
| s.Watt_m | -0.401 |
| s.Jones_m | -0.575 |
| p.FSHD | 6.54e-12 |
| p.hu_model | 0.0146 |
| p.Watt_m | 5.92e-07 |
| p.Jones_m | 7.4e-13 |
| Gene | Jones_m | FSHD |
|---|---|---|
| NDUFB8 | -5016 | -5381 |
| NDUFA5 | -4652 | -4522 |
| ECSIT | -5076 | -4087 |
| NDUFC1 | -4731 | -3946 |
| NDUFB4 | -5024 | -3689 |
| NDUFAF5 | -4659 | -3655 |
| NDUFS1 | -3922 | -4162 |
| NDUFA12 | -5025 | -3042 |
| NDUFAF6 | -5247 | -2865 |
| NDUFS3 | -5085 | -2951 |
| NDUFB6 | -4176 | -3531 |
| TIMMDC1 | -4130 | -3514 |
| NDUFA2 | -4015 | -3321 |
| NDUFA10 | -2953 | -4377 |
| NDUFA9 | -3839 | -3316 |
| MT-ND5 | -2299 | -5424 |
| NDUFS2 | -4544 | -2719 |
| NDUFV1 | -4349 | -2739 |
| NDUFAF4 | -3101 | -3816 |
| NDUFS5 | -4714 | -2493 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACAD9 | -1110 | -4519 | -4508 | -3752 |
| ECSIT | -4087 | -2621 | -2817 | -5076 |
| MT-ND1 | -3295 | -352 | -2191 | -3418 |
| MT-ND2 | -4198 | -1107 | -2067 | -2726 |
| MT-ND4 | -4132 | -2057 | -1579 | -2517 |
| MT-ND5 | -5424 | -3201 | -2302 | -2299 |
| MT-ND6 | -4175 | 806 | -4540 | -2336 |
| NDUFA1 | -2847 | -733 | 306 | -3258 |
| NDUFA10 | -4377 | -1928 | -3087 | -2953 |
| NDUFA11 | -332 | -1021 | -1127 | -4129 |
| NDUFA12 | -3042 | -1299 | -653 | -5025 |
| NDUFA13 | 527 | -2222 | -2529 | -4498 |
| NDUFA2 | -3321 | -1274 | -1958 | -4015 |
| NDUFA3 | -2414 | -3756 | -587 | -3680 |
| NDUFA5 | -4522 | 527 | -1654 | -4652 |
| NDUFA6 | -3995 | -77 | -3352 | 2209 |
| NDUFA7 | -635 | -463 | -1807 | -4700 |
| NDUFA8 | -3418 | -599 | -2482 | -3118 |
| NDUFA9 | -3316 | -2830 | -2055 | -3839 |
| NDUFAB1 | -3229 | 1139 | -3221 | -1911 |
| NDUFAF1 | 159 | 1163 | -4219 | -4277 |
| NDUFAF2 | -2538 | 3477 | -3212 | 1596 |
| NDUFAF3 | -940 | -3534 | -1253 | -805 |
| NDUFAF4 | -3816 | 3710 | -2000 | -3101 |
| NDUFAF5 | -3655 | 28 | -971 | -4659 |
| NDUFAF6 | -2865 | -2523 | -4052 | -5247 |
| NDUFAF7 | -4823 | 2947 | -452 | -803 |
| NDUFB10 | -2966 | -3327 | -2076 | -3543 |
| NDUFB11 | -4516 | -2074 | -2831 | 2192 |
| NDUFB2 | -1608 | -3685 | -956 | -3647 |
| NDUFB3 | -3864 | 841 | -1914 | -2545 |
| NDUFB4 | -3689 | -310 | -1508 | -5024 |
| NDUFB5 | -4024 | -2010 | -1167 | -1274 |
| NDUFB6 | -3531 | 917 | -305 | -4176 |
| NDUFB7 | -2656 | -4168 | -1974 | -3224 |
| NDUFB8 | -5381 | -2981 | -2887 | -5016 |
| NDUFB9 | -1933 | -984 | -3396 | -4313 |
| NDUFC1 | -3946 | -661 | -2874 | -4731 |
| NDUFC2 | -3783 | 32 | -2407 | -2927 |
| NDUFS1 | -4162 | -1524 | -4327 | -3922 |
| NDUFS2 | -2719 | -2987 | -2787 | -4544 |
| NDUFS3 | -2951 | -3520 | -2726 | -5085 |
| NDUFS4 | -2602 | -1667 | -2421 | 914 |
| NDUFS5 | -2493 | -1220 | -1904 | -4714 |
| NDUFS6 | -1709 | -1316 | -973 | -5106 |
| NDUFS7 | -2104 | -4811 | -1886 | -5006 |
| NDUFS8 | -2071 | -4271 | -1979 | -3515 |
| NDUFV1 | -2739 | -4172 | -2709 | -4349 |
| NDUFV3 | -3600 | -2346 | -2565 | -1926 |
| NUBPL | -4866 | -1521 | -3506 | 1659 |
| TIMMDC1 | -3514 | 210 | -1099 | -4130 |
| TMEM126B | -2313 | 1013 | 1849 | 2331 |
Mitochondrial Fatty Acid Beta-Oxidation
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 2.61e-09 |
| p.adjustMANOVA | 3.31e-08 |
| s.dist | 0.903 |
| s.FSHD | -0.516 |
| s.hu_model | -0.351 |
| s.Watt_m | -0.537 |
| s.Jones_m | -0.37 |
| p.FSHD | 1.55e-06 |
| p.hu_model | 0.00106 |
| p.Watt_m | 5.49e-07 |
| p.Jones_m | 0.000568 |
| Gene | Watt_m | FSHD |
|---|---|---|
| ACOT2 | -5094.5 | -5376 |
| ACAD10 | -4840.0 | -5223 |
| PCCA | -5148.0 | -4767 |
| ACOT11 | -5262.0 | -4614 |
| DECR1 | -4729.0 | -4711 |
| ACADM | -4490.0 | -4808 |
| MCEE | -4700.0 | -4437 |
| ACADL | -3889.0 | -4476 |
| PCCB | -4099.0 | -3972 |
| ACADVL | -4253.0 | -3225 |
| HADHB | -3570.0 | -3639 |
| ACOT1 | -5094.5 | -2456 |
| ACOT13 | -3068.0 | -4036 |
| HADH | -5130.0 | -2398 |
| NDUFAB1 | -3221.0 | -3229 |
| ACAA2 | -4939.0 | -2008 |
| ECI1 | -3376.0 | -2823 |
| ACADS | -3951.0 | -2371 |
| HADHA | -2474.0 | -2458 |
| ECHS1 | -4723.0 | -1230 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACAA2 | -2008 | -2298 | -4939.0 | -2039.0 |
| ACAD10 | -5223 | -4506 | -4840.0 | -3561.0 |
| ACADL | -4476 | -1009 | -3889.0 | 477.0 |
| ACADM | -4808 | -1691 | -4490.0 | -853.0 |
| ACADS | -2371 | -4603 | -3951.0 | -299.0 |
| ACADVL | -3225 | -4891 | -4253.0 | -2940.0 |
| ACOT1 | -2456 | 1570 | -5094.5 | -2933.5 |
| ACOT11 | -4614 | -5198 | -5262.0 | -2557.0 |
| ACOT13 | -4036 | -2955 | -3068.0 | -3439.0 |
| ACOT2 | -5376 | -2874 | -5094.5 | -2933.5 |
| ACOT7 | 4896 | -712 | 3007.0 | -929.0 |
| ACOT9 | 2563 | 473 | 4922.0 | 3476.0 |
| ACSF2 | -4841 | -5086 | 1447.0 | 496.0 |
| DBI | -3650 | -2822 | 4352.0 | -2011.0 |
| DECR1 | -4711 | -2583 | -4729.0 | -3467.0 |
| ECHS1 | -1230 | -3845 | -4723.0 | -2015.0 |
| ECI1 | -2823 | -3924 | -3376.0 | -4661.0 |
| HADH | -2398 | -2750 | -5130.0 | -3996.0 |
| HADHA | -2458 | -3160 | -2474.0 | -2529.0 |
| HADHB | -3639 | -2006 | -3570.0 | -3514.0 |
| MCAT | -1336 | -625 | -2788.0 | -3968.0 |
| MCEE | -4437 | -809 | -4700.0 | -253.0 |
| MECR | -1664 | -3148 | -1704.0 | -577.0 |
| MMAA | -1319 | 2774 | -4281.0 | -833.0 |
| NDUFAB1 | -3229 | 1139 | -3221.0 | -1911.0 |
| PCCA | -4767 | -2564 | -5148.0 | -4743.0 |
| PCCB | -3972 | -164 | -4099.0 | -5276.0 |
| PCTP | -1922 | -321 | -1684.0 | 1390.0 |
| THEM4 | -4300 | -3569 | -495.0 | -1003.0 |
Degradation of cysteine and homocysteine
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000519 |
| p.adjustMANOVA | 0.00193 |
| s.dist | 0.902 |
| s.FSHD | -0.289 |
| s.hu_model | -0.302 |
| s.Watt_m | -0.407 |
| s.Jones_m | -0.688 |
| p.FSHD | 0.0833 |
| p.hu_model | 0.07 |
| p.Watt_m | 0.0147 |
| p.Jones_m | 3.64e-05 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| TST | -4978 | -5185 |
| SUOX | -5294 | -4875 |
| MPST | -5097 | -4337 |
| SQRDL | -4169 | -4832 |
| ADO | -4832 | -2693 |
| GADL1 | -2788 | -4111 |
| GOT2 | -2419 | -3058 |
| CSAD | -349 | -2596 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADO | -1946 | 3176 | -2693 | -4832 |
| CDO1 | 4487 | 2019 | 2545 | -3150 |
| CSAD | 2625 | -2112 | -2596 | -349 |
| CTH | -3203 | 4066 | 1061 | -4612 |
| ETHE1 | -1297 | -1826 | 1186 | -3004 |
| GADL1 | -1355 | -5065 | -4111 | -2788 |
| GOT2 | -3182 | -3657 | -3058 | -2419 |
| MPST | -4276 | -5135 | -4337 | -5097 |
| SQRDL | -756 | -3997 | -4832 | -4169 |
| SUOX | -5153 | -2856 | -4875 | -5294 |
| TST | -2901 | -4455 | -5185 | -4978 |
| TXN2 | -3464 | -2801 | 633 | -3212 |
Regulation of pyruvate dehydrogenase (PDH) complex
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.000196 |
| p.adjustMANOVA | 0.000814 |
| s.dist | 0.901 |
| s.FSHD | -0.469 |
| s.hu_model | -0.162 |
| s.Watt_m | -0.631 |
| s.Jones_m | -0.411 |
| p.FSHD | 0.00167 |
| p.hu_model | 0.278 |
| p.Watt_m | 2.34e-05 |
| p.Jones_m | 0.00588 |
| Gene | Watt_m | FSHD |
|---|---|---|
| PDP1 | -4550 | -5181 |
| DLD | -4683 | -4923 |
| RXRA | -4147 | -4228 |
| DLAT | -3783 | -4452 |
| PDK1 | -3198 | -5017 |
| PDK2 | -3496 | -3728 |
| PDHB | -3954 | -3237 |
| PDHA1 | -4403 | -2764 |
| GSTZ1 | -4578 | -2505 |
| PDHX | -3831 | -2958 |
| PDP2 | -2415 | -4664 |
| PPARD | -2316 | -1449 |
| PDPR | -4776 | -614 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| DLAT | -4452 | -1933 | -3783 | -2572 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| GSTZ1 | -2505 | -2039 | -4578 | -3972 |
| PDHA1 | -2764 | -2373 | -4403 | -777 |
| PDHB | -3237 | -133 | -3954 | -943 |
| PDHX | -2958 | -126 | -3831 | -4229 |
| PDK1 | -5017 | 4559 | -3198 | -4230 |
| PDK2 | -3728 | -5386 | -3496 | -5057 |
| PDK3 | 3897 | 4705 | 4816 | 4812 |
| PDK4 | 2105 | -708 | -5180 | -789 |
| PDP1 | -5181 | -2146 | -4550 | -4820 |
| PDP2 | -4664 | -2585 | -2415 | -2584 |
| PDPR | -614 | -629 | -4776 | 2790 |
| PPARD | -1449 | -4159 | -2316 | -2644 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
Interferon alpha/beta signaling
| metric | value |
|---|---|
| setSize | 36 |
| pMANOVA | 3.95e-10 |
| p.adjustMANOVA | 5.72e-09 |
| s.dist | 0.883 |
| s.FSHD | 0.595 |
| s.hu_model | -0.00808 |
| s.Watt_m | 0.35 |
| s.Jones_m | 0.551 |
| p.FSHD | 6.56e-10 |
| p.hu_model | 0.933 |
| p.Watt_m | 0.000278 |
| p.Jones_m | 1.05e-08 |
| Gene | FSHD | Jones_m |
|---|---|---|
| IFITM3 | 5070 | 5021 |
| IFITM1 | 5068 | 5021 |
| IFITM2 | 5066 | 5021 |
| IFI35 | 4092 | 4715 |
| PTPN6 | 3645 | 5055 |
| SOCS3 | 5006 | 3580 |
| EGR1 | 4895 | 3599 |
| MX1 | 4230 | 3968 |
| IRF4 | 4366 | 3509 |
| OAS2 | 3638 | 3785 |
| IRF7 | 4967 | 2598 |
| PSMB8 | 4574 | 2736 |
| IFI27 | 2940 | 4016 |
| STAT2 | 2887 | 3818 |
| ADAR | 2648 | 4124 |
| TYK2 | 2357 | 4512 |
| RNASEL | 2323 | 4286 |
| IRF3 | 4486 | 2206 |
| IRF9 | 3867 | 2491 |
| IP6K2 | 2629 | 3621 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABCE1 | -871 | 4666 | 564 | -3086 |
| ADAR | 2648 | -2975 | 414 | 4124 |
| EGR1 | 4895 | 4131 | 5187 | 3599 |
| IFI27 | 2940 | -1088 | -397 | 4016 |
| IFI35 | 4092 | -3266 | 172 | 4715 |
| IFIT2 | 2444 | -1322 | 794 | 3114 |
| IFIT3 | 3294 | -785 | 1406 | 1365 |
| IFITM1 | 5068 | 1557 | 4767 | 5021 |
| IFITM2 | 5066 | -315 | 4767 | 5021 |
| IFITM3 | 5070 | 377 | 4767 | 5021 |
| IFNAR1 | -1724 | 3617 | 1074 | 4092 |
| IFNAR2 | 1842 | -1300 | 2336 | 3705 |
| IP6K2 | 2629 | 3377 | -655 | 3621 |
| IRF1 | 4221 | -1544 | 974 | -68 |
| IRF2 | 1399 | -3341 | 2237 | 2345 |
| IRF3 | 4486 | -3021 | -113 | 2206 |
| IRF4 | 4366 | -1152 | 2559 | 3509 |
| IRF7 | 4967 | 765 | 3986 | 2598 |
| IRF9 | 3867 | 1253 | 131 | 2491 |
| ISG15 | 3286 | -3878 | 1717 | 1948 |
| JAK1 | 1002 | -1843 | 4184 | -1810 |
| MX1 | 4230 | -1841 | 3181 | 3968 |
| OAS2 | 3638 | 209 | 2041 | 3785 |
| PSMB8 | 4574 | -672 | 2043 | 2736 |
| PTPN1 | 739 | 1514 | 4538 | 4669 |
| PTPN11 | -1703 | -1554 | -660 | -1108 |
| PTPN6 | 3645 | -920 | 4751 | 5055 |
| RNASEL | 2323 | 2882 | 869 | 4286 |
| SAMHD1 | 2145 | 46 | 3023 | 4231 |
| SOCS1 | 4531 | 196 | 3989 | -56 |
| SOCS3 | 5006 | -282 | 5053 | 3580 |
| STAT1 | 2094 | 233 | -1721 | 2082 |
| STAT2 | 2887 | -2568 | 275 | 3818 |
| TYK2 | 2357 | -3081 | -49 | 4512 |
| USP18 | 3625 | 43 | -2543 | 1934 |
| XAF1 | 838 | -319 | -1145 | 1883 |
Chondroitin sulfate biosynthesis
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00038 |
| p.adjustMANOVA | 0.00147 |
| s.dist | 0.875 |
| s.FSHD | 0.718 |
| s.hu_model | -0.106 |
| s.Watt_m | 0.286 |
| s.Jones_m | 0.396 |
| p.FSHD | 7.36e-06 |
| p.hu_model | 0.507 |
| p.Watt_m | 0.0743 |
| p.Jones_m | 0.0133 |
| Gene | FSHD | Jones_m |
|---|---|---|
| BGN | 4348 | 5088 |
| VCAN | 4971 | 4285 |
| CHSY1 | 4080 | 3666 |
| CHST11 | 4013 | 3364 |
| CHPF2 | 4430 | 2836 |
| CSGALNACT1 | 3780 | 3223 |
| CHPF | 4271 | 2760 |
| CHST15 | 4124 | 1275 |
| CSGALNACT2 | 561 | 480 |
| CHST12 | 125 | 1673 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| BGN | 4348 | -1456 | 3875 | 5088 |
| CHPF | 4271 | -4389 | 1240 | 2760 |
| CHPF2 | 4430 | -2038 | 2362 | 2836 |
| CHST11 | 4013 | -183 | 2253 | 3364 |
| CHST12 | 125 | -1250 | 1266 | 1673 |
| CHST15 | 4124 | -4640 | -3177 | 1275 |
| CHST7 | 3877 | 2707 | -1313 | -269 |
| CHSY1 | 4080 | 3773 | 1890 | 3666 |
| CSGALNACT1 | 3780 | -204 | 2536 | 3223 |
| CSGALNACT2 | 561 | 1490 | 3991 | 480 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
PECAM1 interactions
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00525 |
| p.adjustMANOVA | 0.0139 |
| s.dist | 0.873 |
| s.FSHD | 0.516 |
| s.hu_model | -0.25 |
| s.Watt_m | 0.283 |
| s.Jones_m | 0.594 |
| p.FSHD | 0.00472 |
| p.hu_model | 0.17 |
| p.Watt_m | 0.121 |
| p.Jones_m | 0.00115 |
| Gene | Jones_m | FSHD |
|---|---|---|
| PTPN6 | 5055 | 3645 |
| FYN | 4010 | 4466 |
| INPP5D | 5167 | 2998 |
| LYN | 4433 | 3429 |
| SRC | 2269 | 5021 |
| ITGB3 | 2921 | 3693 |
| ITGAV | 4981 | 801 |
| YES1 | 2958 | 1006 |
| PLCG1 | 210 | 1995 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| FYN | 4466 | -2813 | 3642 | 4010 |
| INPP5D | 2998 | -2401 | 4281 | 5167 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGB3 | 3693 | -485 | 4867 | 2921 |
| LYN | 3429 | 775 | 3940 | 4433 |
| PLCG1 | 1995 | -3905 | -4884 | 210 |
| PTPN11 | -1703 | -1554 | -660 | -1108 |
| PTPN6 | 3645 | -920 | 4751 | 5055 |
| SRC | 5021 | -3860 | 1364 | 2269 |
| YES1 | 1006 | -175 | -2910 | 2958 |
Defective B3GALT6 causes EDSP2 and SEMDJL1
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.000106 |
| p.adjustMANOVA | 0.000481 |
| s.dist | 0.865 |
| s.FSHD | 0.615 |
| s.hu_model | -0.454 |
| s.Watt_m | 0.212 |
| s.Jones_m | 0.344 |
| p.FSHD | 6.71e-05 |
| p.hu_model | 0.00325 |
| p.Watt_m | 0.17 |
| p.Jones_m | 0.0261 |
| Gene | FSHD | hu_model |
|---|---|---|
| CSPG4 | 3730 | -5557 |
| AGRN | 3889 | -4843 |
| SDC3 | 3721 | -4560 |
| GPC6 | 4618 | -2353 |
| HSPG2 | 2035 | -5289 |
| SDC1 | 3944 | -2017 |
| BGN | 4348 | -1456 |
| B3GALT6 | 3823 | -1236 |
| DCN | 4452 | -1036 |
| SDC4 | 1095 | -2361 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| B3GALT6 | 3823 | -1236 | 4092 | 3103 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Pyruvate metabolism
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 7.39e-07 |
| p.adjustMANOVA | 6.05e-06 |
| s.dist | 0.863 |
| s.FSHD | -0.491 |
| s.hu_model | -0.228 |
| s.Watt_m | -0.522 |
| s.Jones_m | -0.423 |
| p.FSHD | 1.48e-05 |
| p.hu_model | 0.0445 |
| p.Watt_m | 4.18e-06 |
| p.Jones_m | 0.000188 |
| Gene | Watt_m | FSHD |
|---|---|---|
| PDP1 | -4550 | -5181 |
| DLD | -4683 | -4923 |
| ME1 | -3918 | -4907 |
| VDAC1 | -4553 | -3918 |
| RXRA | -4147 | -4228 |
| GLO1 | -3844 | -4424 |
| DLAT | -3783 | -4452 |
| PDK1 | -3198 | -5017 |
| SLC16A3 | -4114 | -3677 |
| MPC1 | -3199 | -4270 |
| PDK2 | -3496 | -3728 |
| PDHB | -3954 | -3237 |
| PDHA1 | -4403 | -2764 |
| GSTZ1 | -4578 | -2505 |
| PDHX | -3831 | -2958 |
| PDP2 | -2415 | -4664 |
| MPC2 | -1719 | -2780 |
| PPARD | -2316 | -1449 |
| PDPR | -4776 | -614 |
| BSG | -2093 | -1369 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| BSG | -1369 | -2217 | -2093 | -5147 |
| DLAT | -4452 | -1933 | -3783 | -2572 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| GLO1 | -4424 | -675 | -3844 | -4433 |
| GSTZ1 | -2505 | -2039 | -4578 | -3972 |
| HAGH | -2311 | -4451 | 1234 | -3032 |
| LDHA | -341 | -3208 | -2881 | -3674 |
| LDHB | -1357 | -1472 | -1954 | -1554 |
| ME1 | -4907 | 1772 | -3918 | -4943 |
| MPC1 | -4270 | -3634 | -3199 | 4240 |
| MPC2 | -2780 | 819 | -1719 | -3784 |
| PDHA1 | -2764 | -2373 | -4403 | -777 |
| PDHB | -3237 | -133 | -3954 | -943 |
| PDHX | -2958 | -126 | -3831 | -4229 |
| PDK1 | -5017 | 4559 | -3198 | -4230 |
| PDK2 | -3728 | -5386 | -3496 | -5057 |
| PDK3 | 3897 | 4705 | 4816 | 4812 |
| PDK4 | 2105 | -708 | -5180 | -789 |
| PDP1 | -5181 | -2146 | -4550 | -4820 |
| PDP2 | -4664 | -2585 | -2415 | -2584 |
| PDPR | -614 | -629 | -4776 | 2790 |
| PPARD | -1449 | -4159 | -2316 | -2644 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
| SLC16A1 | -2731 | -975 | 5026 | 1675 |
| SLC16A3 | -3677 | -4691 | -4114 | 22 |
| VDAC1 | -3918 | -2871 | -4553 | -5178 |
HS-GAG degradation
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 5.14e-06 |
| p.adjustMANOVA | 3.39e-05 |
| s.dist | 0.86 |
| s.FSHD | 0.573 |
| s.hu_model | -0.435 |
| s.Watt_m | -0.0136 |
| s.Jones_m | 0.471 |
| p.FSHD | 7.2e-05 |
| p.hu_model | 0.00262 |
| p.Watt_m | 0.925 |
| p.Jones_m | 0.0011 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SDC2 | 4456 | 5008 |
| GUSB | 4047 | 5097 |
| SDC3 | 3721 | 4191 |
| GLB1L | 4309 | 3448 |
| GLB1 | 3757 | 3737 |
| NAGLU | 3005 | 4335 |
| SGSH | 3076 | 3931 |
| SDC1 | 3944 | 2683 |
| IDS | 1662 | 4417 |
| HSPG2 | 2035 | 2942 |
| GPC6 | 4618 | 804 |
| AGRN | 3889 | 760 |
| SDC4 | 1095 | 946 |
| IDUA | 4027 | 75 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| GLB1 | 3757 | -2214 | 915 | 3737 |
| GLB1L | 4309 | -1803 | -412 | 3448 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| GUSB | 4047 | 1905 | 4109 | 5097 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| IDS | 1662 | -2441 | -3581 | 4417 |
| IDUA | 4027 | -3817 | -4684 | 75 |
| NAGLU | 3005 | -3661 | -707 | 4335 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| SGSH | 3076 | 701 | -507 | 3931 |
Defective B3GAT3 causes JDSSDHD
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 6.44e-05 |
| p.adjustMANOVA | 0.00031 |
| s.dist | 0.86 |
| s.FSHD | 0.619 |
| s.hu_model | -0.494 |
| s.Watt_m | 0.175 |
| s.Jones_m | 0.285 |
| p.FSHD | 6.16e-05 |
| p.hu_model | 0.00137 |
| p.Watt_m | 0.258 |
| p.Jones_m | 0.0646 |
| Gene | FSHD | hu_model |
|---|---|---|
| CSPG4 | 3730 | -5557 |
| AGRN | 3889 | -4843 |
| SDC3 | 3721 | -4560 |
| B3GAT3 | 4055 | -4180 |
| GPC6 | 4618 | -2353 |
| HSPG2 | 2035 | -5289 |
| SDC1 | 3944 | -2017 |
| BGN | 4348 | -1456 |
| DCN | 4452 | -1036 |
| SDC4 | 1095 | -2361 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| B3GAT3 | 4055 | -4180 | 1326 | -1191 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00186 |
| p.adjustMANOVA | 0.00571 |
| s.dist | 0.857 |
| s.FSHD | 0.102 |
| s.hu_model | 0.115 |
| s.Watt_m | 0.475 |
| s.Jones_m | 0.697 |
| p.FSHD | 0.576 |
| p.hu_model | 0.531 |
| p.Watt_m | 0.00926 |
| p.Jones_m | 0.000136 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| HMGA1 | 5094 | 5049 |
| CDKN1A | 4230 | 5043 |
| UBN1 | 3549 | 3626 |
| TP53 | 2810 | 3708 |
| LMNB1 | 3270 | 2914 |
| ASF1A | 2994 | 2526 |
| RB1 | 5214 | 1448 |
| HIRA | 1964 | 678 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ASF1A | -4236 | 2494 | 2526 | 2994 |
| CABIN1 | 1225 | -2008 | -280 | 4525 |
| CDKN1A | 5043 | -4867 | 5043 | 4230 |
| EP400 | 989 | 2456 | -165 | 2669 |
| HIRA | 2024 | 821 | 678 | 1964 |
| HMGA1 | -3434 | 589 | 5049 | 5094 |
| LMNB1 | 3424 | 3365 | 2914 | 3270 |
| RB1 | -2663 | -2417 | 1448 | 5214 |
| TP53 | 4943 | 566 | 3708 | 2810 |
| UBN1 | -3751 | 2067 | 3626 | 3549 |
The citric acid (TCA) cycle and respiratory electron transport
| metric | value |
|---|---|
| setSize | 142 |
| pMANOVA | 4.04e-38 |
| p.adjustMANOVA | 1.24e-35 |
| s.dist | 0.856 |
| s.FSHD | -0.529 |
| s.hu_model | -0.202 |
| s.Watt_m | -0.423 |
| s.Jones_m | -0.482 |
| p.FSHD | 1.42e-27 |
| p.hu_model | 3.56e-05 |
| p.Watt_m | 3.8e-18 |
| p.Jones_m | 3.89e-23 |
| Gene | FSHD | Jones_m |
|---|---|---|
| NDUFB8 | -5381 | -5016 |
| CS | -5372 | -4669 |
| ADHFE1 | -5136 | -4869 |
| PDP1 | -5181 | -4820 |
| ME1 | -4907 | -4943 |
| IDH3A | -5238 | -4519 |
| L2HGDH | -4395 | -5228 |
| TRAP1 | -4514 | -4770 |
| RXRA | -4228 | -5038 |
| PDK1 | -5017 | -4230 |
| NDUFA5 | -4522 | -4652 |
| COX11 | -4859 | -4306 |
| ECSIT | -4087 | -5076 |
| VDAC1 | -3918 | -5178 |
| SUCLG1 | -3825 | -5153 |
| GLO1 | -4424 | -4433 |
| PDK2 | -3728 | -5057 |
| NDUFC1 | -3946 | -4731 |
| NDUFB4 | -3689 | -5024 |
| IDH3B | -4107 | -4270 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACAD9 | -1110 | -4519 | -4508 | -3752 |
| ACO2 | -3871 | -3773 | -4378 | -3916 |
| ADHFE1 | -5136 | -3988 | -2451 | -4869 |
| BSG | -1369 | -2217 | -2093 | -5147 |
| COQ10A | -4639 | -3506 | -2628 | -3276 |
| COQ10B | 1437 | 4309 | 4211 | -578 |
| COX11 | -4859 | -2823 | -1157 | -4306 |
| COX14 | -4487 | -2736 | -4322 | -2319 |
| COX16 | -1762 | -2228 | -1923 | -3012 |
| COX18 | -3092 | -551 | 627 | -1582 |
| COX19 | -4943 | 3027 | 3451 | -1012 |
| COX20 | -868 | 1092 | -2255 | -2823 |
| COX4I1 | -2361 | -2325 | -1278 | -2561 |
| COX5A | -3222 | -2479 | -2526 | -3071 |
| COX5B | -4740 | -2527 | 452 | -2519 |
| COX6A1 | 3593 | 2239 | 2217 | 2153 |
| COX6B1 | -2721 | -2201 | -849 | -1772 |
| COX6C | -3899 | -18 | -839 | -1015 |
| COX7B | -3033 | 141 | -723 | -359 |
| COX7C | -5186 | -1476 | -175 | -1747 |
| COX8A | -2248 | -4283 | 2616 | 2136 |
| CS | -5372 | 3624 | -3526 | -4669 |
| CYC1 | -2742 | -4094 | -3987 | -3200 |
| D2HGDH | -1446 | -4830 | -5276 | -4528 |
| DLAT | -4452 | -1933 | -3783 | -2572 |
| DLD | -4923 | 1175 | -4683 | -2906 |
| DLST | -3558 | -322 | -3488 | -1773 |
| ECSIT | -4087 | -2621 | -2817 | -5076 |
| ETFA | -3503 | 3133 | -2734 | -460 |
| ETFB | -1680 | -3567 | -2713 | -4113 |
| ETFDH | -4280 | 1866 | -4534 | -2682 |
| FAHD1 | -4055 | -1748 | -4256 | -2464 |
| FH | -4577 | 284 | -2865 | -3264 |
| GLO1 | -4424 | -675 | -3844 | -4433 |
| GSTZ1 | -2505 | -2039 | -4578 | -3972 |
| HAGH | -2311 | -4451 | 1234 | -3032 |
| IDH2 | -2867 | -5154 | -3813 | -2755 |
| IDH3A | -5238 | -2126 | -3782 | -4519 |
| IDH3B | -4107 | -2843 | -2153 | -4270 |
| IDH3G | -896 | -4125 | -3096 | -3697 |
| L2HGDH | -4395 | -261 | -3601 | -5228 |
| LDHA | -341 | -3208 | -2881 | -3674 |
| LDHB | -1357 | -1472 | -1954 | -1554 |
| LRPPRC | -4980 | 1639 | -4343 | -3018 |
| MDH2 | -2694 | -4307 | -2826 | -2711 |
| ME1 | -4907 | 1772 | -3918 | -4943 |
| ME2 | -3037 | -1766 | 3484 | 4800 |
| ME3 | -2144 | 4173 | -3679 | -5302 |
| MPC1 | -4270 | -3634 | -3199 | 4240 |
| MPC2 | -2780 | 819 | -1719 | -3784 |
| MT-CO1 | -4597 | -3125 | -4070 | -3652 |
| MT-CYB | -4704 | -1339 | -2332 | -2471 |
| MT-ND1 | -3295 | -352 | -2191 | -3418 |
| MT-ND2 | -4198 | -1107 | -2067 | -2726 |
| MT-ND4 | -4132 | -2057 | -1579 | -2517 |
| MT-ND5 | -5424 | -3201 | -2302 | -2299 |
| MT-ND6 | -4175 | 806 | -4540 | -2336 |
| NDUFA1 | -2847 | -733 | 306 | -3258 |
| NDUFA10 | -4377 | -1928 | -3087 | -2953 |
| NDUFA11 | -332 | -1021 | -1127 | -4129 |
| NDUFA12 | -3042 | -1299 | -653 | -5025 |
| NDUFA13 | 527 | -2222 | -2529 | -4498 |
| NDUFA2 | -3321 | -1274 | -1958 | -4015 |
| NDUFA3 | -2414 | -3756 | -587 | -3680 |
| NDUFA4 | -2936 | -391 | -676 | -3194 |
| NDUFA5 | -4522 | 527 | -1654 | -4652 |
| NDUFA6 | -3995 | -77 | -3352 | 2209 |
| NDUFA7 | -635 | -463 | -1807 | -4700 |
| NDUFA8 | -3418 | -599 | -2482 | -3118 |
| NDUFA9 | -3316 | -2830 | -2055 | -3839 |
| NDUFAB1 | -3229 | 1139 | -3221 | -1911 |
| NDUFAF1 | 159 | 1163 | -4219 | -4277 |
| NDUFAF2 | -2538 | 3477 | -3212 | 1596 |
| NDUFAF3 | -940 | -3534 | -1253 | -805 |
| NDUFAF4 | -3816 | 3710 | -2000 | -3101 |
| NDUFAF5 | -3655 | 28 | -971 | -4659 |
| NDUFAF6 | -2865 | -2523 | -4052 | -5247 |
| NDUFAF7 | -4823 | 2947 | -452 | -803 |
| NDUFB10 | -2966 | -3327 | -2076 | -3543 |
| NDUFB11 | -4516 | -2074 | -2831 | 2192 |
| NDUFB2 | -1608 | -3685 | -956 | -3647 |
| NDUFB3 | -3864 | 841 | -1914 | -2545 |
| NDUFB4 | -3689 | -310 | -1508 | -5024 |
| NDUFB5 | -4024 | -2010 | -1167 | -1274 |
| NDUFB6 | -3531 | 917 | -305 | -4176 |
| NDUFB7 | -2656 | -4168 | -1974 | -3224 |
| NDUFB8 | -5381 | -2981 | -2887 | -5016 |
| NDUFB9 | -1933 | -984 | -3396 | -4313 |
| NDUFC1 | -3946 | -661 | -2874 | -4731 |
| NDUFC2 | -3783 | 32 | -2407 | -2927 |
| NDUFS1 | -4162 | -1524 | -4327 | -3922 |
| NDUFS2 | -2719 | -2987 | -2787 | -4544 |
| NDUFS3 | -2951 | -3520 | -2726 | -5085 |
| NDUFS4 | -2602 | -1667 | -2421 | 914 |
| NDUFS5 | -2493 | -1220 | -1904 | -4714 |
| NDUFS6 | -1709 | -1316 | -973 | -5106 |
| NDUFS7 | -2104 | -4811 | -1886 | -5006 |
| NDUFS8 | -2071 | -4271 | -1979 | -3515 |
| NDUFV1 | -2739 | -4172 | -2709 | -4349 |
| NDUFV3 | -3600 | -2346 | -2565 | -1926 |
| NNT | -4770 | -3281 | -2350 | -261 |
| NUBPL | -4866 | -1521 | -3506 | 1659 |
| OGDH | -3051 | -5206 | -3610 | -3542 |
| PDHA1 | -2764 | -2373 | -4403 | -777 |
| PDHB | -3237 | -133 | -3954 | -943 |
| PDHX | -2958 | -126 | -3831 | -4229 |
| PDK1 | -5017 | 4559 | -3198 | -4230 |
| PDK2 | -3728 | -5386 | -3496 | -5057 |
| PDK3 | 3897 | 4705 | 4816 | 4812 |
| PDK4 | 2105 | -708 | -5180 | -789 |
| PDP1 | -5181 | -2146 | -4550 | -4820 |
| PDP2 | -4664 | -2585 | -2415 | -2584 |
| PDPR | -614 | -629 | -4776 | 2790 |
| PPARD | -1449 | -4159 | -2316 | -2644 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
| SCO1 | -4774 | 3550 | 1689 | 2341 |
| SCO2 | 1818 | -1915 | -766 | 740 |
| SDHA | -3097 | -4713 | -4539 | -4393 |
| SDHB | -3231 | 427 | -3667 | -3677 |
| SDHC | -4613 | -3665 | -2969 | -3035 |
| SLC16A1 | -2731 | -975 | 5026 | 1675 |
| SLC16A3 | -3677 | -4691 | -4114 | 22 |
| SLC25A14 | 4243 | 3803 | 1851 | 2411 |
| SLC25A27 | -336 | -2446 | -4809 | -4546 |
| SUCLA2 | -4446 | 1500 | -4329 | -3679 |
| SUCLG1 | -3825 | -31 | -2116 | -5153 |
| SUCLG2 | -3363 | -1153 | -4245 | -4203 |
| SURF1 | -696 | -1725 | -4055 | -1565 |
| TACO1 | -3389 | 642 | -4216 | -4383 |
| TIMMDC1 | -3514 | 210 | -1099 | -4130 |
| TMEM126B | -2313 | 1013 | 1849 | 2331 |
| TRAP1 | -4514 | -5203 | -2043 | -4770 |
| UCP2 | 4768 | -4888 | 4991 | 5018 |
| UCP3 | 65 | -681 | -5302 | -499 |
| UQCR10 | -2766 | -3097 | -257 | 2827 |
| UQCRB | -4203 | 400 | -3675 | -1445 |
| UQCRC1 | -2421 | -3288 | -3627 | -4053 |
| UQCRC2 | -4768 | 543 | -3866 | -3335 |
| UQCRFS1 | -2561 | -150 | -3030 | -2834 |
| UQCRH | -3396 | -1512 | -1736 | -1917 |
| UQCRQ | -1949 | -1744 | -1837 | 0 |
| VDAC1 | -3918 | -2871 | -4553 | -5178 |
Respiratory electron transport
| metric | value |
|---|---|
| setSize | 92 |
| pMANOVA | 2.25e-24 |
| p.adjustMANOVA | 2.31e-22 |
| s.dist | 0.841 |
| s.FSHD | -0.549 |
| s.hu_model | -0.177 |
| s.Watt_m | -0.367 |
| s.Jones_m | -0.49 |
| p.FSHD | 9.03e-20 |
| p.hu_model | 0.00334 |
| p.Watt_m | 1.22e-09 |
| p.Jones_m | 5.01e-16 |
| Gene | FSHD | Jones_m |
|---|---|---|
| NDUFB8 | -5381 | -5016 |
| TRAP1 | -4514 | -4770 |
| NDUFA5 | -4522 | -4652 |
| COX11 | -4859 | -4306 |
| ECSIT | -4087 | -5076 |
| NDUFC1 | -3946 | -4731 |
| NDUFB4 | -3689 | -5024 |
| NDUFAF5 | -3655 | -4659 |
| MT-CO1 | -4597 | -3652 |
| NDUFS1 | -4162 | -3922 |
| UQCRC2 | -4768 | -3335 |
| NDUFA12 | -3042 | -5025 |
| COQ10A | -4639 | -3276 |
| NDUFAF6 | -2865 | -5247 |
| LRPPRC | -4980 | -3018 |
| NDUFS3 | -2951 | -5085 |
| TACO1 | -3389 | -4383 |
| NDUFB6 | -3531 | -4176 |
| TIMMDC1 | -3514 | -4130 |
| SDHC | -4613 | -3035 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACAD9 | -1110 | -4519 | -4508 | -3752 |
| COQ10A | -4639 | -3506 | -2628 | -3276 |
| COQ10B | 1437 | 4309 | 4211 | -578 |
| COX11 | -4859 | -2823 | -1157 | -4306 |
| COX14 | -4487 | -2736 | -4322 | -2319 |
| COX16 | -1762 | -2228 | -1923 | -3012 |
| COX18 | -3092 | -551 | 627 | -1582 |
| COX19 | -4943 | 3027 | 3451 | -1012 |
| COX20 | -868 | 1092 | -2255 | -2823 |
| COX4I1 | -2361 | -2325 | -1278 | -2561 |
| COX5A | -3222 | -2479 | -2526 | -3071 |
| COX5B | -4740 | -2527 | 452 | -2519 |
| COX6A1 | 3593 | 2239 | 2217 | 2153 |
| COX6B1 | -2721 | -2201 | -849 | -1772 |
| COX6C | -3899 | -18 | -839 | -1015 |
| COX7B | -3033 | 141 | -723 | -359 |
| COX7C | -5186 | -1476 | -175 | -1747 |
| COX8A | -2248 | -4283 | 2616 | 2136 |
| CYC1 | -2742 | -4094 | -3987 | -3200 |
| ECSIT | -4087 | -2621 | -2817 | -5076 |
| ETFA | -3503 | 3133 | -2734 | -460 |
| ETFB | -1680 | -3567 | -2713 | -4113 |
| ETFDH | -4280 | 1866 | -4534 | -2682 |
| LRPPRC | -4980 | 1639 | -4343 | -3018 |
| MT-CO1 | -4597 | -3125 | -4070 | -3652 |
| MT-CYB | -4704 | -1339 | -2332 | -2471 |
| MT-ND1 | -3295 | -352 | -2191 | -3418 |
| MT-ND2 | -4198 | -1107 | -2067 | -2726 |
| MT-ND4 | -4132 | -2057 | -1579 | -2517 |
| MT-ND5 | -5424 | -3201 | -2302 | -2299 |
| MT-ND6 | -4175 | 806 | -4540 | -2336 |
| NDUFA1 | -2847 | -733 | 306 | -3258 |
| NDUFA10 | -4377 | -1928 | -3087 | -2953 |
| NDUFA11 | -332 | -1021 | -1127 | -4129 |
| NDUFA12 | -3042 | -1299 | -653 | -5025 |
| NDUFA13 | 527 | -2222 | -2529 | -4498 |
| NDUFA2 | -3321 | -1274 | -1958 | -4015 |
| NDUFA3 | -2414 | -3756 | -587 | -3680 |
| NDUFA4 | -2936 | -391 | -676 | -3194 |
| NDUFA5 | -4522 | 527 | -1654 | -4652 |
| NDUFA6 | -3995 | -77 | -3352 | 2209 |
| NDUFA7 | -635 | -463 | -1807 | -4700 |
| NDUFA8 | -3418 | -599 | -2482 | -3118 |
| NDUFA9 | -3316 | -2830 | -2055 | -3839 |
| NDUFAB1 | -3229 | 1139 | -3221 | -1911 |
| NDUFAF1 | 159 | 1163 | -4219 | -4277 |
| NDUFAF2 | -2538 | 3477 | -3212 | 1596 |
| NDUFAF3 | -940 | -3534 | -1253 | -805 |
| NDUFAF4 | -3816 | 3710 | -2000 | -3101 |
| NDUFAF5 | -3655 | 28 | -971 | -4659 |
| NDUFAF6 | -2865 | -2523 | -4052 | -5247 |
| NDUFAF7 | -4823 | 2947 | -452 | -803 |
| NDUFB10 | -2966 | -3327 | -2076 | -3543 |
| NDUFB11 | -4516 | -2074 | -2831 | 2192 |
| NDUFB2 | -1608 | -3685 | -956 | -3647 |
| NDUFB3 | -3864 | 841 | -1914 | -2545 |
| NDUFB4 | -3689 | -310 | -1508 | -5024 |
| NDUFB5 | -4024 | -2010 | -1167 | -1274 |
| NDUFB6 | -3531 | 917 | -305 | -4176 |
| NDUFB7 | -2656 | -4168 | -1974 | -3224 |
| NDUFB8 | -5381 | -2981 | -2887 | -5016 |
| NDUFB9 | -1933 | -984 | -3396 | -4313 |
| NDUFC1 | -3946 | -661 | -2874 | -4731 |
| NDUFC2 | -3783 | 32 | -2407 | -2927 |
| NDUFS1 | -4162 | -1524 | -4327 | -3922 |
| NDUFS2 | -2719 | -2987 | -2787 | -4544 |
| NDUFS3 | -2951 | -3520 | -2726 | -5085 |
| NDUFS4 | -2602 | -1667 | -2421 | 914 |
| NDUFS5 | -2493 | -1220 | -1904 | -4714 |
| NDUFS6 | -1709 | -1316 | -973 | -5106 |
| NDUFS7 | -2104 | -4811 | -1886 | -5006 |
| NDUFS8 | -2071 | -4271 | -1979 | -3515 |
| NDUFV1 | -2739 | -4172 | -2709 | -4349 |
| NDUFV3 | -3600 | -2346 | -2565 | -1926 |
| NUBPL | -4866 | -1521 | -3506 | 1659 |
| SCO1 | -4774 | 3550 | 1689 | 2341 |
| SCO2 | 1818 | -1915 | -766 | 740 |
| SDHA | -3097 | -4713 | -4539 | -4393 |
| SDHB | -3231 | 427 | -3667 | -3677 |
| SDHC | -4613 | -3665 | -2969 | -3035 |
| SURF1 | -696 | -1725 | -4055 | -1565 |
| TACO1 | -3389 | 642 | -4216 | -4383 |
| TIMMDC1 | -3514 | 210 | -1099 | -4130 |
| TMEM126B | -2313 | 1013 | 1849 | 2331 |
| TRAP1 | -4514 | -5203 | -2043 | -4770 |
| UQCR10 | -2766 | -3097 | -257 | 2827 |
| UQCRB | -4203 | 400 | -3675 | -1445 |
| UQCRC1 | -2421 | -3288 | -3627 | -4053 |
| UQCRC2 | -4768 | 543 | -3866 | -3335 |
| UQCRFS1 | -2561 | -150 | -3030 | -2834 |
| UQCRH | -3396 | -1512 | -1736 | -1917 |
| UQCRQ | -1949 | -1744 | -1837 | 0 |
tRNA Aminoacylation
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 2.34e-06 |
| p.adjustMANOVA | 1.63e-05 |
| s.dist | 0.84 |
| s.FSHD | -0.588 |
| s.hu_model | 0.185 |
| s.Watt_m | -0.405 |
| s.Jones_m | -0.402 |
| p.FSHD | 6.22e-07 |
| p.hu_model | 0.118 |
| p.Watt_m | 0.000597 |
| p.Jones_m | 0.000665 |
| Gene | FSHD | Watt_m |
|---|---|---|
| IARS2 | -4937 | -5169 |
| SARS2 | -4125 | -4633 |
| LARS2 | -4758 | -4016 |
| DARS2 | -5377 | -3100 |
| CARS2 | -4742 | -3294 |
| NARS2 | -4447 | -3318 |
| VARS2 | -2948 | -4902 |
| HARS2 | -4878 | -2721 |
| TARS2 | -2811 | -4285 |
| FARS2 | -3653 | -2932 |
| AIMP2 | -3584 | -2586 |
| AARS2 | -1823 | -4573 |
| MARS2 | -3770 | -2080 |
| EARS2 | -4338 | -1492 |
| YARS2 | -2279 | -2282 |
| AIMP1 | -4862 | -866 |
| PPA2 | -4060 | -958 |
| RARS2 | -891 | -2276 |
| PARS2 | -1167 | -205 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AARS2 | -1823 | -2636 | -4573 | -3348 |
| AIMP1 | -4862 | 1405 | -866 | -4104 |
| AIMP2 | -3584 | -2692 | -2586 | -5021 |
| CARS2 | -4742 | -2732 | -3294 | -89 |
| DARS2 | -5377 | 1623 | -3100 | -2855 |
| EARS2 | -4338 | -2461 | -1492 | -3698 |
| EEF1E1 | 42 | 2819 | 2913 | -2589 |
| FARS2 | -3653 | 2730 | -2932 | 707 |
| FARSA | 126 | -1780 | -861 | -1287 |
| FARSB | -4646 | 3318 | 2662 | -3177 |
| HARS2 | -4878 | 4682 | -2721 | -4375 |
| IARS2 | -4937 | 1933 | -5169 | -2267 |
| LARS2 | -4758 | 2101 | -4016 | -678 |
| MARS2 | -3770 | 4644 | -2080 | -2858 |
| NARS2 | -4447 | 2027 | -3318 | -1778 |
| PARS2 | -1167 | 2627 | -205 | -727 |
| PPA1 | -4622 | 1505 | 822 | -3074 |
| PPA2 | -4060 | -162 | -958 | -194 |
| RARS2 | -891 | -56 | -2276 | 163 |
| SARS2 | -4125 | -3536 | -4633 | -3521 |
| TARS2 | -2811 | -523 | -4285 | -2628 |
| VARS2 | -2948 | -2605 | -4902 | -2295 |
| WARS2 | 33 | -880 | -2086 | 425 |
| YARS2 | -2279 | 4816 | -2282 | -2242 |
Mucopolysaccharidoses
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000404 |
| p.adjustMANOVA | 0.00156 |
| s.dist | 0.834 |
| s.FSHD | 0.463 |
| s.hu_model | -0.335 |
| s.Watt_m | 0.00854 |
| s.Jones_m | 0.607 |
| p.FSHD | 0.00783 |
| p.hu_model | 0.0544 |
| p.Watt_m | 0.961 |
| p.Jones_m | 0.000486 |
| Gene | Jones_m | FSHD |
|---|---|---|
| GALNS | 4953 | 4194 |
| GUSB | 5097 | 4047 |
| GLB1 | 3737 | 3757 |
| NAGLU | 4335 | 3005 |
| SGSH | 3931 | 3076 |
| GNS | 4550 | 2638 |
| IDS | 4417 | 1662 |
| ARSB | 3584 | 471 |
| IDUA | 75 | 4027 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ARSB | 471 | -989 | 2803 | 3584 |
| GALNS | 4194 | -3909 | 4498 | 4953 |
| GLB1 | 3757 | -2214 | 915 | 3737 |
| GNS | 2638 | 98 | -972 | 4550 |
| GUSB | 4047 | 1905 | 4109 | 5097 |
| HGSNAT | 3140 | -4541 | -3490 | -30 |
| HYAL1 | -5197 | -3796 | 1588 | 129 |
| IDS | 1662 | -2441 | -3581 | 4417 |
| IDUA | 4027 | -3817 | -4684 | 75 |
| NAGLU | 3005 | -3661 | -707 | 4335 |
| SGSH | 3076 | 701 | -507 | 3931 |
Defective B4GALT7 causes EDS, progeroid type
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.000158 |
| p.adjustMANOVA | 0.000678 |
| s.dist | 0.828 |
| s.FSHD | 0.574 |
| s.hu_model | -0.493 |
| s.Watt_m | 0.136 |
| s.Jones_m | 0.308 |
| p.FSHD | 0.000203 |
| p.hu_model | 0.0014 |
| p.Watt_m | 0.379 |
| p.Jones_m | 0.0458 |
| Gene | FSHD | hu_model |
|---|---|---|
| CSPG4 | 3730 | -5557 |
| AGRN | 3889 | -4843 |
| SDC3 | 3721 | -4560 |
| GPC6 | 4618 | -2353 |
| HSPG2 | 2035 | -5289 |
| SDC1 | 3944 | -2017 |
| BGN | 4348 | -1456 |
| DCN | 4452 | -1036 |
| B4GALT7 | 746 | -4099 |
| SDC4 | 1095 | -2361 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| B4GALT7 | 746 | -4099 | -1523 | 513 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Activation of Matrix Metalloproteinases
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00243 |
| p.adjustMANOVA | 0.00724 |
| s.dist | 0.826 |
| s.FSHD | 0.655 |
| s.hu_model | -0.307 |
| s.Watt_m | 0.193 |
| s.Jones_m | 0.349 |
| p.FSHD | 0.000169 |
| p.hu_model | 0.0782 |
| p.Watt_m | 0.268 |
| p.Jones_m | 0.0448 |
| Gene | FSHD | Jones_m |
|---|---|---|
| TIMP1 | 4933 | 4988 |
| CTSK | 4644 | 4241 |
| MMP17 | 2906 | 5161 |
| COL18A1 | 4351 | 3090 |
| MMP14 | 4687 | 2675 |
| MMP2 | 4410 | 2240 |
| TIMP2 | 4689 | 1606 |
| MMP11 | 2889 | 1218 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| CTSK | 4644 | 2 | 259 | 4241 |
| CTSV | -84 | 2189 | 34 | 331 |
| FURIN | 1239 | -4167 | 4073 | -1204 |
| MMP11 | 2889 | -3240 | -393 | 1218 |
| MMP14 | 4687 | -1668 | 1618 | 2675 |
| MMP15 | 1264 | -5090 | -5214 | -4505 |
| MMP17 | 2906 | -2335 | 5119 | 5161 |
| MMP2 | 4410 | -689 | -1983 | 2240 |
| TIMP1 | 4933 | -1301 | 5188 | 4988 |
| TIMP2 | 4689 | -1860 | -732 | 1606 |
Scavenging by Class A Receptors
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00156 |
| p.adjustMANOVA | 0.00493 |
| s.dist | 0.817 |
| s.FSHD | 0.6 |
| s.hu_model | -0.195 |
| s.Watt_m | 0.204 |
| s.Jones_m | 0.478 |
| p.FSHD | 0.00018 |
| p.hu_model | 0.223 |
| p.Watt_m | 0.204 |
| p.Jones_m | 0.00284 |
| Gene | FSHD | Jones_m |
|---|---|---|
| MSR1 | 5020 | 4999 |
| APOE | 3947 | 4717 |
| CALR | 3782 | 4356 |
| COL3A1 | 4565 | 3575 |
| HSP90B1 | 3464 | 4544 |
| COLEC12 | 4753 | 3221 |
| COL4A2 | 3851 | 3295 |
| COL4A1 | 3805 | 3236 |
| COL1A2 | 4681 | 1250 |
| COL1A1 | 4847 | 676 |
| SCARA5 | 4409 | 415 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| APOE | 3947 | -1411 | -88 | 4717 |
| CALR | 3782 | 1517 | 4947 | 4356 |
| COL1A1 | 4847 | -1617 | 7 | 676 |
| COL1A2 | 4681 | -1689 | -375 | 1250 |
| COL3A1 | 4565 | 2950 | 2503 | 3575 |
| COL4A1 | 3805 | -4695 | 688 | 3236 |
| COL4A2 | 3851 | -4973 | 861 | 3295 |
| COLEC12 | 4753 | 4226 | 45 | 3221 |
| FTH1 | -3005 | -1864 | -126 | 409 |
| HSP90B1 | 3464 | 456 | 4896 | 4544 |
| MASP1 | -5427 | -4170 | -1574 | -2446 |
| MSR1 | 5020 | -3413 | 5009 | 4999 |
| SCARA5 | 4409 | -2526 | -3487 | 415 |
rRNA processing in the mitochondrion
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0103 |
| p.adjustMANOVA | 0.0243 |
| s.dist | 0.814 |
| s.FSHD | -0.589 |
| s.hu_model | -0.0373 |
| s.Watt_m | -0.367 |
| s.Jones_m | -0.423 |
| p.FSHD | 0.000714 |
| p.hu_model | 0.83 |
| p.Watt_m | 0.035 |
| p.Jones_m | 0.0152 |
| Gene | FSHD | Jones_m |
|---|---|---|
| MT-CO1 | -4597 | -3652 |
| TRMT10C | -4316 | -3659 |
| MT-ND5 | -5424 | -2299 |
| MT-CYB | -4704 | -2471 |
| MT-ND2 | -4198 | -2726 |
| MT-ND1 | -3295 | -3418 |
| MT-ND4 | -4132 | -2517 |
| NSUN4 | -1691 | -4928 |
| TFB1M | -1773 | -3272 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ELAC2 | -1785 | 1503 | 1552 | 116 |
| HSD17B10 | -201 | -1178 | -480 | 3967 |
| MT-CO1 | -4597 | -3125 | -4070 | -3652 |
| MT-CYB | -4704 | -1339 | -2332 | -2471 |
| MT-ND1 | -3295 | -352 | -2191 | -3418 |
| MT-ND2 | -4198 | -1107 | -2067 | -2726 |
| MT-ND4 | -4132 | -2057 | -1579 | -2517 |
| MT-ND5 | -5424 | -3201 | -2302 | -2299 |
| NSUN4 | -1691 | -822 | -4973 | -4928 |
| TFB1M | -1773 | 1520 | -3331 | -3272 |
| TRMT10C | -4316 | 4737 | -8 | -3659 |
Carnitine metabolism
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00397 |
| p.adjustMANOVA | 0.0111 |
| s.dist | 0.813 |
| s.FSHD | -0.275 |
| s.hu_model | -0.434 |
| s.Watt_m | -0.568 |
| s.Jones_m | -0.272 |
| p.FSHD | 0.114 |
| p.hu_model | 0.0128 |
| p.Watt_m | 0.00112 |
| p.Jones_m | 0.118 |
| Gene | Watt_m | hu_model |
|---|---|---|
| RXRA | -4147 | -5455 |
| THRSP | -4589 | -4254 |
| PRKAA2 | -5106 | -3176 |
| SLC22A5 | -2909 | -4594 |
| PRKAG2 | -3494 | -3194 |
| PPARD | -2316 | -4159 |
| PRKAB2 | -2793 | -2300 |
| SLC25A20 | -1424 | -3464 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CPT1A | 3750 | -356 | 324 | 4495 |
| CPT2 | -3090 | 547 | -5234 | -3083 |
| MID1IP1 | -5004 | 2039 | -1702 | 2896 |
| PPARD | -1449 | -4159 | -2316 | -2644 |
| PRKAA2 | -3931 | -3176 | -5106 | -4407 |
| PRKAB2 | -2523 | -2300 | -2793 | -5257 |
| PRKAG2 | -382 | -3194 | -3494 | 2548 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
| SLC22A5 | -3713 | -4594 | -2909 | -2085 |
| SLC25A20 | -683 | -3464 | -1424 | -2559 |
| THRSP | 3306 | -4254 | -4589 | -1021 |
Cell recruitment (pro-inflammatory response)
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00863 |
| p.adjustMANOVA | 0.0209 |
| s.dist | 0.81 |
| s.FSHD | 0.518 |
| s.hu_model | -0.0205 |
| s.Watt_m | 0.347 |
| s.Jones_m | 0.517 |
| p.FSHD | 0.00189 |
| p.hu_model | 0.902 |
| p.Watt_m | 0.0372 |
| p.Jones_m | 0.00194 |
| Gene | FSHD | Jones_m |
|---|---|---|
| NFKB2 | 5031 | 5030 |
| P2RX4 | 4810 | 4918 |
| PYCARD | 4190 | 4818 |
| C3 | 4737 | 4049 |
| CASP1 | 3545 | 4113 |
| NFKB1 | 4613 | 3086 |
| TXN | 3016 | 4226 |
| RELA | 3940 | 1891 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| C3 | 4737 | 4276 | 1818 | 4049 |
| CASP1 | 3545 | -1282 | 3136 | 4113 |
| ENTPD5 | -4867 | -3984 | -3379 | -1327 |
| HSP90AB1 | -1913 | -636 | 4582 | 723 |
| NFKB1 | 4613 | -4179 | 3276 | 3086 |
| NFKB2 | 5031 | -3876 | 3297 | 5030 |
| NT5E | 4703 | 1980 | -3594 | -2534 |
| P2RX4 | 4810 | -1095 | 2834 | 4918 |
| PYCARD | 4190 | -2774 | 4656 | 4818 |
| RELA | 3940 | 1766 | 4484 | 1891 |
| SUGT1 | -1257 | 3113 | -4483 | 3225 |
| TXN | 3016 | 1838 | 4743 | 4226 |
Purinergic signaling in leishmaniasis infection
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00863 |
| p.adjustMANOVA | 0.0209 |
| s.dist | 0.81 |
| s.FSHD | 0.518 |
| s.hu_model | -0.0205 |
| s.Watt_m | 0.347 |
| s.Jones_m | 0.517 |
| p.FSHD | 0.00189 |
| p.hu_model | 0.902 |
| p.Watt_m | 0.0372 |
| p.Jones_m | 0.00194 |
| Gene | FSHD | Jones_m |
|---|---|---|
| NFKB2 | 5031 | 5030 |
| P2RX4 | 4810 | 4918 |
| PYCARD | 4190 | 4818 |
| C3 | 4737 | 4049 |
| CASP1 | 3545 | 4113 |
| NFKB1 | 4613 | 3086 |
| TXN | 3016 | 4226 |
| RELA | 3940 | 1891 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| C3 | 4737 | 4276 | 1818 | 4049 |
| CASP1 | 3545 | -1282 | 3136 | 4113 |
| ENTPD5 | -4867 | -3984 | -3379 | -1327 |
| HSP90AB1 | -1913 | -636 | 4582 | 723 |
| NFKB1 | 4613 | -4179 | 3276 | 3086 |
| NFKB2 | 5031 | -3876 | 3297 | 5030 |
| NT5E | 4703 | 1980 | -3594 | -2534 |
| P2RX4 | 4810 | -1095 | 2834 | 4918 |
| PYCARD | 4190 | -2774 | 4656 | 4818 |
| RELA | 3940 | 1766 | 4484 | 1891 |
| SUGT1 | -1257 | 3113 | -4483 | 3225 |
| TXN | 3016 | 1838 | 4743 | 4226 |
A tetrasaccharide linker sequence is required for GAG synthesis
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 1.98e-05 |
| p.adjustMANOVA | 0.000107 |
| s.dist | 0.797 |
| s.FSHD | 0.6 |
| s.hu_model | -0.413 |
| s.Watt_m | 0.21 |
| s.Jones_m | 0.246 |
| p.FSHD | 1.06e-05 |
| p.hu_model | 0.00243 |
| p.Watt_m | 0.124 |
| p.Jones_m | 0.0704 |
| Gene | FSHD | hu_model |
|---|---|---|
| CSPG4 | 3730 | -5557 |
| AGRN | 3889 | -4843 |
| SDC3 | 3721 | -4560 |
| B3GAT3 | 4055 | -4180 |
| GPC6 | 4618 | -2353 |
| HSPG2 | 2035 | -5289 |
| SDC1 | 3944 | -2017 |
| BGN | 4348 | -1456 |
| B3GALT6 | 3823 | -1236 |
| DCN | 4452 | -1036 |
| B4GALT7 | 746 | -4099 |
| SDC4 | 1095 | -2361 |
| XYLT2 | 2228 | -1124 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| B3GALT6 | 3823 | -1236 | 4092 | 3103 |
| B3GAT3 | 4055 | -4180 | 1326 | -1191 |
| B4GALT7 | 746 | -4099 | -1523 | 513 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
| XYLT1 | 3695 | 2589 | 2917 | -2537 |
| XYLT2 | 2228 | -1124 | 1315 | 1093 |
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
| metric | value |
|---|---|
| setSize | 96 |
| pMANOVA | 1.91e-22 |
| p.adjustMANOVA | 1.47e-20 |
| s.dist | 0.795 |
| s.FSHD | -0.508 |
| s.hu_model | -0.176 |
| s.Watt_m | -0.358 |
| s.Jones_m | -0.464 |
| p.FSHD | 8.8e-18 |
| p.hu_model | 0.00292 |
| p.Watt_m | 1.41e-09 |
| p.Jones_m | 3.97e-15 |
| Gene | FSHD | Jones_m |
|---|---|---|
| NDUFB8 | -5381 | -5016 |
| TRAP1 | -4514 | -4770 |
| NDUFA5 | -4522 | -4652 |
| COX11 | -4859 | -4306 |
| ECSIT | -4087 | -5076 |
| NDUFC1 | -3946 | -4731 |
| NDUFB4 | -3689 | -5024 |
| NDUFAF5 | -3655 | -4659 |
| MT-CO1 | -4597 | -3652 |
| NDUFS1 | -4162 | -3922 |
| UQCRC2 | -4768 | -3335 |
| NDUFA12 | -3042 | -5025 |
| COQ10A | -4639 | -3276 |
| NDUFAF6 | -2865 | -5247 |
| LRPPRC | -4980 | -3018 |
| NDUFS3 | -2951 | -5085 |
| TACO1 | -3389 | -4383 |
| NDUFB6 | -3531 | -4176 |
| TIMMDC1 | -3514 | -4130 |
| SDHC | -4613 | -3035 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACAD9 | -1110 | -4519 | -4508 | -3752 |
| COQ10A | -4639 | -3506 | -2628 | -3276 |
| COQ10B | 1437 | 4309 | 4211 | -578 |
| COX11 | -4859 | -2823 | -1157 | -4306 |
| COX14 | -4487 | -2736 | -4322 | -2319 |
| COX16 | -1762 | -2228 | -1923 | -3012 |
| COX18 | -3092 | -551 | 627 | -1582 |
| COX19 | -4943 | 3027 | 3451 | -1012 |
| COX20 | -868 | 1092 | -2255 | -2823 |
| COX4I1 | -2361 | -2325 | -1278 | -2561 |
| COX5A | -3222 | -2479 | -2526 | -3071 |
| COX5B | -4740 | -2527 | 452 | -2519 |
| COX6A1 | 3593 | 2239 | 2217 | 2153 |
| COX6B1 | -2721 | -2201 | -849 | -1772 |
| COX6C | -3899 | -18 | -839 | -1015 |
| COX7B | -3033 | 141 | -723 | -359 |
| COX7C | -5186 | -1476 | -175 | -1747 |
| COX8A | -2248 | -4283 | 2616 | 2136 |
| CYC1 | -2742 | -4094 | -3987 | -3200 |
| ECSIT | -4087 | -2621 | -2817 | -5076 |
| ETFA | -3503 | 3133 | -2734 | -460 |
| ETFB | -1680 | -3567 | -2713 | -4113 |
| ETFDH | -4280 | 1866 | -4534 | -2682 |
| LRPPRC | -4980 | 1639 | -4343 | -3018 |
| MT-CO1 | -4597 | -3125 | -4070 | -3652 |
| MT-CYB | -4704 | -1339 | -2332 | -2471 |
| MT-ND1 | -3295 | -352 | -2191 | -3418 |
| MT-ND2 | -4198 | -1107 | -2067 | -2726 |
| MT-ND4 | -4132 | -2057 | -1579 | -2517 |
| MT-ND5 | -5424 | -3201 | -2302 | -2299 |
| MT-ND6 | -4175 | 806 | -4540 | -2336 |
| NDUFA1 | -2847 | -733 | 306 | -3258 |
| NDUFA10 | -4377 | -1928 | -3087 | -2953 |
| NDUFA11 | -332 | -1021 | -1127 | -4129 |
| NDUFA12 | -3042 | -1299 | -653 | -5025 |
| NDUFA13 | 527 | -2222 | -2529 | -4498 |
| NDUFA2 | -3321 | -1274 | -1958 | -4015 |
| NDUFA3 | -2414 | -3756 | -587 | -3680 |
| NDUFA4 | -2936 | -391 | -676 | -3194 |
| NDUFA5 | -4522 | 527 | -1654 | -4652 |
| NDUFA6 | -3995 | -77 | -3352 | 2209 |
| NDUFA7 | -635 | -463 | -1807 | -4700 |
| NDUFA8 | -3418 | -599 | -2482 | -3118 |
| NDUFA9 | -3316 | -2830 | -2055 | -3839 |
| NDUFAB1 | -3229 | 1139 | -3221 | -1911 |
| NDUFAF1 | 159 | 1163 | -4219 | -4277 |
| NDUFAF2 | -2538 | 3477 | -3212 | 1596 |
| NDUFAF3 | -940 | -3534 | -1253 | -805 |
| NDUFAF4 | -3816 | 3710 | -2000 | -3101 |
| NDUFAF5 | -3655 | 28 | -971 | -4659 |
| NDUFAF6 | -2865 | -2523 | -4052 | -5247 |
| NDUFAF7 | -4823 | 2947 | -452 | -803 |
| NDUFB10 | -2966 | -3327 | -2076 | -3543 |
| NDUFB11 | -4516 | -2074 | -2831 | 2192 |
| NDUFB2 | -1608 | -3685 | -956 | -3647 |
| NDUFB3 | -3864 | 841 | -1914 | -2545 |
| NDUFB4 | -3689 | -310 | -1508 | -5024 |
| NDUFB5 | -4024 | -2010 | -1167 | -1274 |
| NDUFB6 | -3531 | 917 | -305 | -4176 |
| NDUFB7 | -2656 | -4168 | -1974 | -3224 |
| NDUFB8 | -5381 | -2981 | -2887 | -5016 |
| NDUFB9 | -1933 | -984 | -3396 | -4313 |
| NDUFC1 | -3946 | -661 | -2874 | -4731 |
| NDUFC2 | -3783 | 32 | -2407 | -2927 |
| NDUFS1 | -4162 | -1524 | -4327 | -3922 |
| NDUFS2 | -2719 | -2987 | -2787 | -4544 |
| NDUFS3 | -2951 | -3520 | -2726 | -5085 |
| NDUFS4 | -2602 | -1667 | -2421 | 914 |
| NDUFS5 | -2493 | -1220 | -1904 | -4714 |
| NDUFS6 | -1709 | -1316 | -973 | -5106 |
| NDUFS7 | -2104 | -4811 | -1886 | -5006 |
| NDUFS8 | -2071 | -4271 | -1979 | -3515 |
| NDUFV1 | -2739 | -4172 | -2709 | -4349 |
| NDUFV3 | -3600 | -2346 | -2565 | -1926 |
| NUBPL | -4866 | -1521 | -3506 | 1659 |
| SCO1 | -4774 | 3550 | 1689 | 2341 |
| SCO2 | 1818 | -1915 | -766 | 740 |
| SDHA | -3097 | -4713 | -4539 | -4393 |
| SDHB | -3231 | 427 | -3667 | -3677 |
| SDHC | -4613 | -3665 | -2969 | -3035 |
| SLC25A14 | 4243 | 3803 | 1851 | 2411 |
| SLC25A27 | -336 | -2446 | -4809 | -4546 |
| SURF1 | -696 | -1725 | -4055 | -1565 |
| TACO1 | -3389 | 642 | -4216 | -4383 |
| TIMMDC1 | -3514 | 210 | -1099 | -4130 |
| TMEM126B | -2313 | 1013 | 1849 | 2331 |
| TRAP1 | -4514 | -5203 | -2043 | -4770 |
| UCP2 | 4768 | -4888 | 4991 | 5018 |
| UCP3 | 65 | -681 | -5302 | -499 |
| UQCR10 | -2766 | -3097 | -257 | 2827 |
| UQCRB | -4203 | 400 | -3675 | -1445 |
| UQCRC1 | -2421 | -3288 | -3627 | -4053 |
| UQCRC2 | -4768 | 543 | -3866 | -3335 |
| UQCRFS1 | -2561 | -150 | -3030 | -2834 |
| UQCRH | -3396 | -1512 | -1736 | -1917 |
| UQCRQ | -1949 | -1744 | -1837 | 0 |
Caspase activation via Death Receptors in the presence of ligand
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0137 |
| p.adjustMANOVA | 0.0306 |
| s.dist | 0.789 |
| s.FSHD | 0.489 |
| s.hu_model | -0.239 |
| s.Watt_m | 0.339 |
| s.Jones_m | 0.458 |
| p.FSHD | 0.00496 |
| p.hu_model | 0.17 |
| p.Watt_m | 0.0515 |
| p.Jones_m | 0.0085 |
| Gene | FSHD | Jones_m |
|---|---|---|
| CASP8 | 4576 | 4108.0 |
| TLR4 | 3937 | 4750.0 |
| TRADD | 4253 | 4079.0 |
| FAS | 3526 | 3480.0 |
| RIPK1 | 2917 | 2881.0 |
| TICAM1 | 1746 | 3735.0 |
| TNFRSF10B | 4919 | 1242.5 |
| TNFRSF10A | 3009 | 1242.5 |
| FADD | 588 | 4118.0 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CASP8 | 4576 | -1624 | 3056.0 | 4108.0 |
| CFLAR | -5410 | -5487 | -3552.0 | -2793.0 |
| FADD | 588 | -568 | 4829.0 | 4118.0 |
| FAS | 3526 | -4711 | 2867.0 | 3480.0 |
| RIPK1 | 2917 | 322 | 711.0 | 2881.0 |
| TICAM1 | 1746 | 1607 | 4325.0 | 3735.0 |
| TLR4 | 3937 | 1053 | 4868.0 | 4750.0 |
| TNFRSF10A | 3009 | -3886 | 1248.5 | 1242.5 |
| TNFRSF10B | 4919 | -1590 | 1248.5 | 1242.5 |
| TRADD | 4253 | -702 | -1459.0 | 4079.0 |
| TRAF2 | 2276 | -1526 | 970.0 | -697.0 |
Collagen degradation
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 5.57e-06 |
| p.adjustMANOVA | 3.58e-05 |
| s.dist | 0.775 |
| s.FSHD | 0.602 |
| s.hu_model | -0.274 |
| s.Watt_m | 0.015 |
| s.Jones_m | 0.403 |
| p.FSHD | 3.18e-06 |
| p.hu_model | 0.0337 |
| p.Watt_m | 0.907 |
| p.Jones_m | 0.00179 |
| Gene | FSHD | Jones_m |
|---|---|---|
| MMP19 | 4747 | 5126 |
| COL14A1 | 4785 | 4769 |
| CTSK | 4644 | 4241 |
| COL18A1 | 4351 | 3090 |
| CTSB | 2843 | 4639 |
| MMP14 | 4687 | 2675 |
| MMP2 | 4410 | 2240 |
| COL16A1 | 3846 | 2475 |
| ADAM10 | 2507 | 3455 |
| COL12A1 | 5001 | 1626 |
| COL23A1 | 3199 | 2418 |
| MMP11 | 2889 | 1218 |
| CTSD | 1329 | 2582 |
| COL15A1 | 2478 | 1179 |
| ADAM17 | 411 | 2726 |
| ADAM9 | 261 | 3770 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADAM10 | 2507 | -1489 | -1018 | 3455 |
| ADAM17 | 411 | 2385 | 2056 | 2726 |
| ADAM9 | 261 | 342 | 148 | 3770 |
| COL12A1 | 5001 | 1907 | 511 | 1626 |
| COL13A1 | -180 | -2295 | -1942 | 1914 |
| COL14A1 | 4785 | 831 | 1493 | 4769 |
| COL15A1 | 2478 | -169 | 1436 | 1179 |
| COL16A1 | 3846 | -2915 | 1643 | 2475 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL23A1 | 3199 | -4585 | -845 | 2418 |
| CTSB | 2843 | -1183 | -789 | 4639 |
| CTSD | 1329 | -4757 | -3993 | 2582 |
| CTSK | 4644 | 2 | 259 | 4241 |
| FURIN | 1239 | -4167 | 4073 | -1204 |
| MMP11 | 2889 | -3240 | -393 | 1218 |
| MMP14 | 4687 | -1668 | 1618 | 2675 |
| MMP15 | 1264 | -5090 | -5214 | -4505 |
| MMP19 | 4747 | -167 | 4806 | 5126 |
| MMP2 | 4410 | -689 | -1983 | 2240 |
| PHYKPL | 4956 | -4988 | -3912 | -2713 |
Diseases associated with the TLR signaling cascade
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.000963 |
| p.adjustMANOVA | 0.00329 |
| s.dist | 0.772 |
| s.FSHD | 0.358 |
| s.hu_model | -0.174 |
| s.Watt_m | 0.318 |
| s.Jones_m | 0.58 |
| p.FSHD | 0.0133 |
| p.hu_model | 0.228 |
| p.Watt_m | 0.0278 |
| p.Jones_m | 5.89e-05 |
| Gene | Jones_m | FSHD |
|---|---|---|
| NFKB2 | 5030 | 5031 |
| TLR4 | 4750 | 3937 |
| MYD88 | 3583 | 4634 |
| NFKB1 | 3086 | 4613 |
| IRAK4 | 3193 | 3956 |
| TLR6 | 4168 | 2753 |
| TLR5 | 4899 | 1981 |
| RELA | 1891 | 3940 |
| TRAF3 | 2668 | 2612 |
| TICAM1 | 3735 | 1746 |
| TLR3 | 2981 | 2103 |
| NFKBIA | 1289 | 204 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CD36 | -653 | -579 | -3797 | 1232 |
| CHUK | -5003 | 213 | 946 | 4752 |
| IKBKB | -4380 | -4041 | 570 | 3732 |
| IRAK4 | 3956 | -566 | 1954 | 3193 |
| MYD88 | 4634 | 2702 | 4632 | 3583 |
| NFKB1 | 4613 | -4179 | 3276 | 3086 |
| NFKB2 | 5031 | -3876 | 3297 | 5030 |
| NFKBIA | 204 | -4209 | 4052 | 1289 |
| RELA | 3940 | 1766 | 4484 | 1891 |
| TICAM1 | 1746 | 1607 | 4325 | 3735 |
| TIRAP | -273 | -2904 | -3591 | -2727 |
| TLR3 | 2103 | -309 | -3670 | 2981 |
| TLR4 | 3937 | 1053 | 4868 | 4750 |
| TLR5 | 1981 | -3191 | 918 | 4899 |
| TLR6 | 2753 | 877 | 1284 | 4168 |
| TRAF3 | 2612 | -3766 | 2438 | 2668 |
Diseases of Immune System
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.000963 |
| p.adjustMANOVA | 0.00329 |
| s.dist | 0.772 |
| s.FSHD | 0.358 |
| s.hu_model | -0.174 |
| s.Watt_m | 0.318 |
| s.Jones_m | 0.58 |
| p.FSHD | 0.0133 |
| p.hu_model | 0.228 |
| p.Watt_m | 0.0278 |
| p.Jones_m | 5.89e-05 |
| Gene | Jones_m | FSHD |
|---|---|---|
| NFKB2 | 5030 | 5031 |
| TLR4 | 4750 | 3937 |
| MYD88 | 3583 | 4634 |
| NFKB1 | 3086 | 4613 |
| IRAK4 | 3193 | 3956 |
| TLR6 | 4168 | 2753 |
| TLR5 | 4899 | 1981 |
| RELA | 1891 | 3940 |
| TRAF3 | 2668 | 2612 |
| TICAM1 | 3735 | 1746 |
| TLR3 | 2981 | 2103 |
| NFKBIA | 1289 | 204 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CD36 | -653 | -579 | -3797 | 1232 |
| CHUK | -5003 | 213 | 946 | 4752 |
| IKBKB | -4380 | -4041 | 570 | 3732 |
| IRAK4 | 3956 | -566 | 1954 | 3193 |
| MYD88 | 4634 | 2702 | 4632 | 3583 |
| NFKB1 | 4613 | -4179 | 3276 | 3086 |
| NFKB2 | 5031 | -3876 | 3297 | 5030 |
| NFKBIA | 204 | -4209 | 4052 | 1289 |
| RELA | 3940 | 1766 | 4484 | 1891 |
| TICAM1 | 1746 | 1607 | 4325 | 3735 |
| TIRAP | -273 | -2904 | -3591 | -2727 |
| TLR3 | 2103 | -309 | -3670 | 2981 |
| TLR4 | 3937 | 1053 | 4868 | 4750 |
| TLR5 | 1981 | -3191 | 918 | 4899 |
| TLR6 | 2753 | 877 | 1284 | 4168 |
| TRAF3 | 2612 | -3766 | 2438 | 2668 |
Mitochondrial calcium ion transport
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 7.14e-05 |
| p.adjustMANOVA | 0.000339 |
| s.dist | 0.772 |
| s.FSHD | -0.598 |
| s.hu_model | -0.0111 |
| s.Watt_m | -0.338 |
| s.Jones_m | -0.351 |
| p.FSHD | 2.12e-06 |
| p.hu_model | 0.93 |
| p.Watt_m | 0.00732 |
| p.Jones_m | 0.00533 |
| Gene | FSHD | Jones_m |
|---|---|---|
| VDAC3 | -5295 | -4968 |
| MICU3 | -4344 | -4758 |
| VDAC1 | -3918 | -5178 |
| PMPCA | -3040 | -4811 |
| SPG7 | -3269 | -4377 |
| PHB | -3242 | -4330 |
| YME1L1 | -5076 | -2146 |
| C2orf47 | -4691 | -2251 |
| VDAC2 | -2987 | -3338 |
| STOML2 | -2788 | -3383 |
| SLC8A3 | -1730 | -4578 |
| AFG3L2 | -4583 | -1568 |
| AKAP1 | -4443 | -1523 |
| PMPCB | -5065 | -1223 |
| PHB2 | -3483 | -1389 |
| LETM1 | -2627 | -145 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AFG3L2 | -4583 | -1974 | -3074 | -1568 |
| AKAP1 | -4443 | -5031 | -4236 | -1523 |
| C2orf47 | -4691 | 4125 | -472 | -2251 |
| LETM1 | -2627 | -552 | -4525 | -145 |
| MCU | -820 | 416 | 1521 | 4976 |
| MICU1 | -1998 | 4883 | 2372 | 3567 |
| MICU2 | -4462 | -606 | 1264 | 3704 |
| MICU3 | -4344 | 2577 | -2525 | -4758 |
| PARL | 220 | 762 | -4126 | -2890 |
| PHB | -3242 | -583 | -2096 | -4330 |
| PHB2 | -3483 | 584 | -889 | -1389 |
| PMPCA | -3040 | -92 | -4554 | -4811 |
| PMPCB | -5065 | -824 | -3599 | -1223 |
| SLC8A3 | -1730 | -5413 | -3845 | -4578 |
| SMDT1 | -2173 | -3739 | -157 | 1060 |
| SPG7 | -3269 | -4482 | -3652 | -4377 |
| STOML2 | -2788 | 1967 | 314 | -3383 |
| VDAC1 | -3918 | -2871 | -4553 | -5178 |
| VDAC2 | -2987 | -1424 | -2473 | -3338 |
| VDAC3 | -5295 | 524 | 3115 | -4968 |
| YME1L1 | -5076 | 4303 | -2155 | -2146 |
MET activates PTK2 signaling
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.000331 |
| p.adjustMANOVA | 0.00131 |
| s.dist | 0.769 |
| s.FSHD | 0.587 |
| s.hu_model | -0.431 |
| s.Watt_m | 0.0361 |
| s.Jones_m | 0.244 |
| p.FSHD | 0.000144 |
| p.hu_model | 0.00524 |
| p.Watt_m | 0.815 |
| p.Jones_m | 0.114 |
| Gene | FSHD | hu_model |
|---|---|---|
| ITGA3 | 4809 | -5450 |
| LAMA5 | 3521 | -5520 |
| SRC | 5021 | -3860 |
| LAMB2 | 3450 | -4834 |
| LAMC1 | 4113 | -3181 |
| LAMA2 | 3038 | -3750 |
| LAMB3 | 2231 | -4929 |
| LAMA3 | 3451 | -999 |
| PTK2 | 692 | -2465 |
| LAMB1 | 2539 | -455 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ITGA3 | 4809 | -5450 | 2976 | 557 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| LAMA2 | 3038 | -3750 | -756 | 2040 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMA4 | 4388 | 736 | -121 | 2343 |
| LAMA5 | 3521 | -5520 | -2717 | -2028 |
| LAMB1 | 2539 | -455 | -385 | 3101 |
| LAMB2 | 3450 | -4834 | -3037 | -2486 |
| LAMB3 | 2231 | -4929 | -4569 | 386 |
| LAMC1 | 4113 | -3181 | 2501 | 4089 |
| LAMC2 | 4587 | 1336 | 5102 | 4436 |
| MET | -2044 | -3482 | 2897 | 4177 |
| PTK2 | 692 | -2465 | -1494 | -4001 |
| SRC | 5021 | -3860 | 1364 | 2269 |
Acyl chain remodelling of PS
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0123 |
| p.adjustMANOVA | 0.0279 |
| s.dist | 0.767 |
| s.FSHD | 0.414 |
| s.hu_model | 0.218 |
| s.Watt_m | 0.215 |
| s.Jones_m | 0.568 |
| p.FSHD | 0.0233 |
| p.hu_model | 0.234 |
| p.Watt_m | 0.238 |
| p.Jones_m | 0.00186 |
| Gene | Jones_m | FSHD |
|---|---|---|
| PLA2R1 | 4946 | 4029 |
| OSBPL10 | 4344 | 4129 |
| OSBPL8 | 4794 | 2879 |
| PLA2G4A | 3078 | 4275 |
| LPCAT4 | 2121 | 4462 |
| PLA1A | 3458 | 1853 |
| OSBPL5 | 2260 | 2610 |
| MBOAT1 | 4267 | 1080 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| LPCAT3 | -672 | 4190 | -2687 | -1766 |
| LPCAT4 | 4462 | -1170 | 3757 | 2121 |
| MBOAT1 | 1080 | 3887 | 4795 | 4267 |
| OSBPL10 | 4129 | 4 | 914 | 4344 |
| OSBPL5 | 2610 | -4800 | -552 | 2260 |
| OSBPL8 | 2879 | 4837 | 4358 | 4794 |
| PLA1A | 1853 | -1363 | 2239 | 3458 |
| PLA2G12A | -4644 | 2245 | -2020 | 2064 |
| PLA2G4A | 4275 | 594 | 3662 | 3078 |
| PLA2R1 | 4029 | 63 | -3602 | 4946 |
Voltage gated Potassium channels
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00104 |
| p.adjustMANOVA | 0.00354 |
| s.dist | 0.767 |
| s.FSHD | 0.212 |
| s.hu_model | -0.528 |
| s.Watt_m | -0.361 |
| s.Jones_m | -0.365 |
| p.FSHD | 0.223 |
| p.hu_model | 0.00243 |
| p.Watt_m | 0.038 |
| p.Jones_m | 0.0359 |
| Gene | hu_model | Jones_m |
|---|---|---|
| KCNC4 | -4849 | -5210 |
| KCNA7 | -5080 | -4397 |
| KCNB1 | -5055 | -4312 |
| KCNQ5 | -3706 | -4990 |
| KCNQ4 | -5558 | -1338 |
| KCNC1 | -3294 | -2070 |
| KCNC3 | -364 | -3280 |
| KCNH2 | -3484 | -248 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| KCNA1 | 3484 | 4556 | 2104 | -2224 |
| KCNA7 | -3572 | -5080 | -3447 | -4397 |
| KCNAB2 | 3225 | -3156 | 4972 | 4840 |
| KCNB1 | 484 | -5055 | -5008 | -4312 |
| KCNC1 | -4268 | -3294 | -5258 | -2070 |
| KCNC3 | 3323 | -364 | 1008 | -3280 |
| KCNC4 | 3670 | -4849 | -5217 | -5210 |
| KCNH2 | 982 | -3484 | -1469 | -248 |
| KCNQ1 | 3848 | -3838 | 557 | 1681 |
| KCNQ4 | 2223 | -5558 | -4977 | -1338 |
| KCNQ5 | -3117 | -3706 | -4711 | -4990 |
Mitochondrial translation
| metric | value |
|---|---|
| setSize | 87 |
| pMANOVA | 1.59e-19 |
| p.adjustMANOVA | 1.02e-17 |
| s.dist | 0.764 |
| s.FSHD | -0.554 |
| s.hu_model | 0.159 |
| s.Watt_m | -0.315 |
| s.Jones_m | -0.389 |
| p.FSHD | 4.1e-19 |
| p.hu_model | 0.0107 |
| p.Watt_m | 4.08e-07 |
| p.Jones_m | 3.59e-10 |
| Gene | FSHD | Jones_m |
|---|---|---|
| GFM1 | -5327 | -4196 |
| PTCD3 | -5161 | -4052 |
| DAP3 | -4837 | -4034 |
| MRPL30 | -4564 | -4158 |
| GFM2 | -3662 | -5127 |
| MRPL42 | -3577 | -5202 |
| MRPS36 | -5429 | -3208 |
| MRPL32 | -4818 | -3602 |
| MTRF1L | -5397 | -3157 |
| MTIF2 | -4920 | -3415 |
| MRPS18B | -4367 | -3831 |
| MRPS5 | -3273 | -5089 |
| CHCHD1 | -3980 | -3974 |
| MRPL16 | -4392 | -3597 |
| MRPL11 | -3720 | -4218 |
| TUFM | -3802 | -4101 |
| MRPS16 | -4590 | -3231 |
| MRPS15 | -3628 | -4018 |
| MRPS23 | -4659 | -3082 |
| OXA1L | -4632 | -3044 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AURKAIP1 | -3378 | -2276 | -1747 | -3524 |
| CHCHD1 | -3980 | -540 | -1809 | -3974 |
| DAP3 | -4837 | -461 | 2611 | -4034 |
| ERAL1 | -3167 | 2585 | -858 | -3141 |
| GADD45GIP1 | -1089 | -2386 | -3149 | -2950 |
| GFM1 | -5327 | 4168 | -4357 | -4196 |
| GFM2 | -3662 | 3786 | -5236 | -5127 |
| MRPL1 | -3901 | -1280 | -4021 | -2985 |
| MRPL10 | -2288 | -2374 | -4353 | -2443 |
| MRPL11 | -3720 | 2077 | -2512 | -4218 |
| MRPL12 | -1963 | -2623 | -2727 | -2667 |
| MRPL13 | -3539 | 343 | 285 | -3672 |
| MRPL14 | -1974 | -1679 | -1052 | 1359 |
| MRPL15 | -3132 | 2448 | -2949 | -4325 |
| MRPL16 | -4392 | 3057 | -3392 | -3597 |
| MRPL17 | 595 | 1912 | 2816 | 4209 |
| MRPL18 | -2407 | 2971 | -4191 | -3349 |
| MRPL19 | -4475 | 4046 | -3671 | -1186 |
| MRPL2 | -2747 | -435 | -1567 | -4868 |
| MRPL20 | -3024 | 531 | 207 | -510 |
| MRPL21 | -3086 | 1674 | -768 | -3347 |
| MRPL22 | -2171 | 3326 | -2754 | -3733 |
| MRPL23 | -3087 | -3178 | -776 | -1241 |
| MRPL24 | -1464 | -1858 | -2181 | -1722 |
| MRPL27 | -2722 | -1594 | -1652 | -1044 |
| MRPL28 | -7 | -271 | -990 | -2552 |
| MRPL3 | -3854 | 2949 | -3937 | -192 |
| MRPL30 | -4564 | 3470 | -1084 | -4158 |
| MRPL32 | -4818 | 3042 | 2692 | -3602 |
| MRPL34 | -3944 | -2159 | -3284 | -2255 |
| MRPL35 | -5028 | 800 | -2563 | -2768 |
| MRPL36 | -2568 | -557 | -2264 | 625 |
| MRPL37 | -2913 | 1590 | -2744 | -3921 |
| MRPL38 | -490 | 368 | -1753 | -3644 |
| MRPL39 | -3867 | 2569 | -947 | -1196 |
| MRPL4 | -1740 | 2929 | -505 | -2748 |
| MRPL40 | -2857 | -249 | 796 | 637 |
| MRPL41 | -4483 | -4838 | -1856 | 1777 |
| MRPL42 | -3577 | 2087 | -1650 | -5202 |
| MRPL43 | -1019 | -1428 | -663 | 1286 |
| MRPL44 | -3543 | 4365 | -2069 | -3706 |
| MRPL46 | -2332 | 996 | -440 | 1568 |
| MRPL47 | -1558 | 3146 | -1887 | -1504 |
| MRPL48 | -3651 | -80 | 163 | -1871 |
| MRPL49 | -468 | 4723 | -3219 | -2978 |
| MRPL50 | -3974 | 3074 | -150 | -1267 |
| MRPL51 | -2492 | -387 | -1581 | -4128 |
| MRPL52 | -1075 | -2282 | 1466 | -1004 |
| MRPL54 | 445 | -1970 | 2366 | -2983 |
| MRPL55 | -932 | 1077 | -3210 | -3400 |
| MRPL9 | -2162 | 3406 | -3593 | -1971 |
| MRPS10 | -2227 | -3045 | -784 | -2392 |
| MRPS11 | -3081 | 280 | -2798 | -1751 |
| MRPS12 | -2364 | -146 | 616 | 1122 |
| MRPS14 | -1834 | 1778 | -4387 | -4044 |
| MRPS15 | -3628 | 1857 | -1464 | -4018 |
| MRPS16 | -4590 | 1192 | -2229 | -3231 |
| MRPS17 | -3181 | -131 | -1389 | 4388 |
| MRPS18A | -2481 | 465 | -4081 | -4980 |
| MRPS18B | -4367 | -1848 | 1877 | -3831 |
| MRPS18C | -3506 | 4342 | -675 | -570 |
| MRPS2 | -2046 | 1425 | 2175 | -19 |
| MRPS22 | -4388 | 4344 | -1949 | -275 |
| MRPS23 | -4659 | 1657 | -4044 | -3082 |
| MRPS25 | -3226 | -3514 | -3925 | 431 |
| MRPS26 | -646 | -610 | -1343 | -2703 |
| MRPS27 | -4915 | 555 | -2134 | -2848 |
| MRPS28 | -2816 | 1341 | -1288 | -4916 |
| MRPS30 | -3672 | 3442 | 761 | -2570 |
| MRPS31 | -4207 | 3479 | -1758 | -2995 |
| MRPS33 | -4017 | 149 | -530 | -1199 |
| MRPS34 | -2775 | -3797 | -2222 | -3830 |
| MRPS35 | -4450 | 3080 | -2647 | 954 |
| MRPS36 | -5429 | -2678 | 682 | -3208 |
| MRPS5 | -3273 | -1161 | -2766 | -5089 |
| MRPS6 | 1135 | -4408 | 2857 | -486 |
| MRPS7 | -3579 | -1321 | 849 | 138 |
| MRPS9 | -3785 | 1389 | -4076 | -1007 |
| MRRF | -2365 | -2758 | -206 | -1218 |
| MTFMT | -3046 | -1437 | -1940 | 1267 |
| MTIF2 | -4920 | 1787 | -4751 | -3415 |
| MTIF3 | -4258 | 276 | -1404 | 3305 |
| MTRF1L | -5397 | 1502 | -3819 | -3157 |
| OXA1L | -4632 | -2587 | -3906 | -3044 |
| PTCD3 | -5161 | 3456 | -5112 | -4052 |
| TSFM | -3801 | 1946 | -2884 | 3728 |
| TUFM | -3802 | -2555 | -3791 | -4101 |
Syndecan interactions
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.00145 |
| p.adjustMANOVA | 0.00464 |
| s.dist | 0.761 |
| s.FSHD | 0.544 |
| s.hu_model | -0.0484 |
| s.Watt_m | 0.357 |
| s.Jones_m | 0.392 |
| p.FSHD | 0.000104 |
| p.hu_model | 0.73 |
| p.Watt_m | 0.0108 |
| p.Jones_m | 0.00521 |
| Gene | FSHD | Jones_m |
|---|---|---|
| ACTN1 | 4991 | 4955 |
| SDC2 | 4456 | 5008 |
| THBS1 | 4954 | 3647 |
| TNC | 5019 | 3460 |
| TGFB1 | 4177 | 4099 |
| SDC3 | 3721 | 4191 |
| ITGB3 | 3693 | 2921 |
| SDC1 | 3944 | 2683 |
| CASK | 1599 | 3957 |
| ITGB1 | 891 | 4783 |
| ITGAV | 801 | 4981 |
| SDC4 | 1095 | 946 |
| TRAPPC4 | 41 | 1401 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACTN1 | 4991 | -673 | 3653 | 4955 |
| CASK | 1599 | 2860 | 3171 | 3957 |
| FGF2 | 1476 | 741 | -1087 | -3508 |
| ITGA6 | 1799 | -990 | -5243 | -114 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB3 | 3693 | -485 | 4867 | 2921 |
| ITGB5 | 3604 | -2545 | -4743 | -4839 |
| PRKCA | -720 | -2900 | -2894 | -4160 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| TGFB1 | 4177 | -3070 | 4895 | 4099 |
| THBS1 | 4954 | 752 | 4384 | 3647 |
| TNC | 5019 | 793 | 4283 | 3460 |
| TRAPPC4 | 41 | 3212 | 2700 | 1401 |
N-Glycan antennae elongation
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00608 |
| p.adjustMANOVA | 0.0156 |
| s.dist | 0.759 |
| s.FSHD | 0.262 |
| s.hu_model | -0.26 |
| s.Watt_m | 0.429 |
| s.Jones_m | 0.505 |
| p.FSHD | 0.116 |
| p.hu_model | 0.118 |
| p.Watt_m | 0.01 |
| p.Jones_m | 0.00247 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| B4GALT5 | 5074 | 4122 |
| ST8SIA2 | 4293 | 3919 |
| B4GALT6 | 5160 | 3047 |
| ST3GAL4 | 3256 | 3728 |
| MGAT5 | 3834 | 2701 |
| ST6GAL1 | 3388 | 1734 |
| B4GALT2 | 2616 | 2193 |
| B4GALT1 | 1643 | 2563 |
| MGAT4A | 943 | 3278 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| B4GALT1 | 1688 | -1298 | 2563 | 1643 |
| B4GALT2 | -256 | -4979 | 2193 | 2616 |
| B4GALT3 | 624 | 963 | 1156 | -435 |
| B4GALT4 | 140 | 1624 | -695 | 2909 |
| B4GALT5 | -3265 | -4015 | 4122 | 5074 |
| B4GALT6 | -3537 | 2681 | 3047 | 5160 |
| MGAT4A | 2876 | 265 | 3278 | 943 |
| MGAT4B | 3709 | -4647 | -1197 | -1234 |
| MGAT5 | 4691 | 2988 | 2701 | 3834 |
| ST3GAL4 | 3433 | -2907 | 3728 | 3256 |
| ST6GAL1 | 72 | -5325 | 1734 | 3388 |
| ST8SIA2 | 4218 | -5360 | 3919 | 4293 |
Other interleukin signaling
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00741 |
| p.adjustMANOVA | 0.0184 |
| s.dist | 0.757 |
| s.FSHD | 0.554 |
| s.hu_model | -0.131 |
| s.Watt_m | 0.267 |
| s.Jones_m | 0.421 |
| p.FSHD | 0.000543 |
| p.hu_model | 0.412 |
| p.Watt_m | 0.0955 |
| p.Jones_m | 0.0086 |
| Gene | FSHD | Jones_m |
|---|---|---|
| IL10RB | 4957 | 4242 |
| CSF1 | 4653 | 3814 |
| IL16 | 3962 | 2759 |
| TYK2 | 2357 | 4512 |
| SDC1 | 3944 | 2683 |
| STX4 | 2959 | 3083 |
| CASP3 | 1918 | 4110 |
| STX1A | 2700 | 1638 |
| IL34 | 3608 | 1009 |
| TXLNA | 525 | 1982 |
| VAMP2 | 835 | 1196 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CASP3 | 1918 | 419 | 4968 | 4110 |
| CSF1 | 4653 | -4188 | 4312 | 3814 |
| IL10RB | 4957 | 1225 | 3206 | 4242 |
| IL16 | 3962 | -1591 | -1353 | 2759 |
| IL34 | 3608 | 3034 | -1526 | 1009 |
| JAK1 | 1002 | -1843 | 4184 | -1810 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| STX1A | 2700 | -409 | 1596 | 1638 |
| STX3 | 2125 | 4340 | -2442 | -877 |
| STX4 | 2959 | -2315 | 77 | 3083 |
| TXLNA | 525 | -3173 | 2681 | 1982 |
| TYK2 | 2357 | -3081 | -49 | 4512 |
| VAMP2 | 835 | -3250 | 1792 | 1196 |
Biotin transport and metabolism
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0396 |
| p.adjustMANOVA | 0.075 |
| s.dist | 0.757 |
| s.FSHD | -0.323 |
| s.hu_model | -0.0201 |
| s.Watt_m | -0.535 |
| s.Jones_m | -0.426 |
| p.FSHD | 0.0766 |
| p.hu_model | 0.912 |
| p.Watt_m | 0.00339 |
| p.Jones_m | 0.0198 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| PCCA | -5148 | -4743 |
| MCCC2 | -4913 | -4935 |
| ACACB | -4941 | -4435 |
| PCCB | -4099 | -5276 |
| MCCC1 | -4638 | -4559 |
| PC | -3656 | -4683 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACACB | -2494 | -5314 | -4941 | -4435 |
| BTD | 2964 | 2543 | 2171 | -688 |
| HLCS | -4775 | -754 | -3859 | 1637 |
| MCCC1 | -4819 | 3980 | -4638 | -4559 |
| MCCC2 | -4989 | 2184 | -4913 | -4935 |
| PC | 929 | -5164 | -3656 | -4683 |
| PCCA | -4767 | -2564 | -5148 | -4743 |
| PCCB | -3972 | -164 | -4099 | -5276 |
| PDZD11 | 1299 | 1661 | 484 | 4847 |
| SLC5A6 | 1784 | -431 | -42 | 72 |
Mitochondrial translation termination
| metric | value |
|---|---|
| setSize | 81 |
| pMANOVA | 1.65e-17 |
| p.adjustMANOVA | 8.47e-16 |
| s.dist | 0.754 |
| s.FSHD | -0.538 |
| s.hu_model | 0.156 |
| s.Watt_m | -0.293 |
| s.Jones_m | -0.411 |
| p.FSHD | 5.73e-17 |
| p.hu_model | 0.0152 |
| p.Watt_m | 5.2e-06 |
| p.Jones_m | 1.77e-10 |
| Gene | FSHD | Jones_m |
|---|---|---|
| PTCD3 | -5161 | -4052 |
| DAP3 | -4837 | -4034 |
| MRPL30 | -4564 | -4158 |
| GFM2 | -3662 | -5127 |
| MRPL42 | -3577 | -5202 |
| MRPS36 | -5429 | -3208 |
| MRPL32 | -4818 | -3602 |
| MTRF1L | -5397 | -3157 |
| MRPS18B | -4367 | -3831 |
| MRPS5 | -3273 | -5089 |
| CHCHD1 | -3980 | -3974 |
| MRPL16 | -4392 | -3597 |
| MRPL11 | -3720 | -4218 |
| MRPS16 | -4590 | -3231 |
| MRPS15 | -3628 | -4018 |
| MRPS23 | -4659 | -3082 |
| OXA1L | -4632 | -3044 |
| MRPS27 | -4915 | -2848 |
| MRPL35 | -5028 | -2768 |
| MRPS28 | -2816 | -4916 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AURKAIP1 | -3378 | -2276 | -1747 | -3524 |
| CHCHD1 | -3980 | -540 | -1809 | -3974 |
| DAP3 | -4837 | -461 | 2611 | -4034 |
| ERAL1 | -3167 | 2585 | -858 | -3141 |
| GADD45GIP1 | -1089 | -2386 | -3149 | -2950 |
| GFM2 | -3662 | 3786 | -5236 | -5127 |
| MRPL1 | -3901 | -1280 | -4021 | -2985 |
| MRPL10 | -2288 | -2374 | -4353 | -2443 |
| MRPL11 | -3720 | 2077 | -2512 | -4218 |
| MRPL12 | -1963 | -2623 | -2727 | -2667 |
| MRPL13 | -3539 | 343 | 285 | -3672 |
| MRPL14 | -1974 | -1679 | -1052 | 1359 |
| MRPL15 | -3132 | 2448 | -2949 | -4325 |
| MRPL16 | -4392 | 3057 | -3392 | -3597 |
| MRPL17 | 595 | 1912 | 2816 | 4209 |
| MRPL18 | -2407 | 2971 | -4191 | -3349 |
| MRPL19 | -4475 | 4046 | -3671 | -1186 |
| MRPL2 | -2747 | -435 | -1567 | -4868 |
| MRPL20 | -3024 | 531 | 207 | -510 |
| MRPL21 | -3086 | 1674 | -768 | -3347 |
| MRPL22 | -2171 | 3326 | -2754 | -3733 |
| MRPL23 | -3087 | -3178 | -776 | -1241 |
| MRPL24 | -1464 | -1858 | -2181 | -1722 |
| MRPL27 | -2722 | -1594 | -1652 | -1044 |
| MRPL28 | -7 | -271 | -990 | -2552 |
| MRPL3 | -3854 | 2949 | -3937 | -192 |
| MRPL30 | -4564 | 3470 | -1084 | -4158 |
| MRPL32 | -4818 | 3042 | 2692 | -3602 |
| MRPL34 | -3944 | -2159 | -3284 | -2255 |
| MRPL35 | -5028 | 800 | -2563 | -2768 |
| MRPL36 | -2568 | -557 | -2264 | 625 |
| MRPL37 | -2913 | 1590 | -2744 | -3921 |
| MRPL38 | -490 | 368 | -1753 | -3644 |
| MRPL39 | -3867 | 2569 | -947 | -1196 |
| MRPL4 | -1740 | 2929 | -505 | -2748 |
| MRPL40 | -2857 | -249 | 796 | 637 |
| MRPL41 | -4483 | -4838 | -1856 | 1777 |
| MRPL42 | -3577 | 2087 | -1650 | -5202 |
| MRPL43 | -1019 | -1428 | -663 | 1286 |
| MRPL44 | -3543 | 4365 | -2069 | -3706 |
| MRPL46 | -2332 | 996 | -440 | 1568 |
| MRPL47 | -1558 | 3146 | -1887 | -1504 |
| MRPL48 | -3651 | -80 | 163 | -1871 |
| MRPL49 | -468 | 4723 | -3219 | -2978 |
| MRPL50 | -3974 | 3074 | -150 | -1267 |
| MRPL51 | -2492 | -387 | -1581 | -4128 |
| MRPL52 | -1075 | -2282 | 1466 | -1004 |
| MRPL54 | 445 | -1970 | 2366 | -2983 |
| MRPL55 | -932 | 1077 | -3210 | -3400 |
| MRPL9 | -2162 | 3406 | -3593 | -1971 |
| MRPS10 | -2227 | -3045 | -784 | -2392 |
| MRPS11 | -3081 | 280 | -2798 | -1751 |
| MRPS12 | -2364 | -146 | 616 | 1122 |
| MRPS14 | -1834 | 1778 | -4387 | -4044 |
| MRPS15 | -3628 | 1857 | -1464 | -4018 |
| MRPS16 | -4590 | 1192 | -2229 | -3231 |
| MRPS17 | -3181 | -131 | -1389 | 4388 |
| MRPS18A | -2481 | 465 | -4081 | -4980 |
| MRPS18B | -4367 | -1848 | 1877 | -3831 |
| MRPS18C | -3506 | 4342 | -675 | -570 |
| MRPS2 | -2046 | 1425 | 2175 | -19 |
| MRPS22 | -4388 | 4344 | -1949 | -275 |
| MRPS23 | -4659 | 1657 | -4044 | -3082 |
| MRPS25 | -3226 | -3514 | -3925 | 431 |
| MRPS26 | -646 | -610 | -1343 | -2703 |
| MRPS27 | -4915 | 555 | -2134 | -2848 |
| MRPS28 | -2816 | 1341 | -1288 | -4916 |
| MRPS30 | -3672 | 3442 | 761 | -2570 |
| MRPS31 | -4207 | 3479 | -1758 | -2995 |
| MRPS33 | -4017 | 149 | -530 | -1199 |
| MRPS34 | -2775 | -3797 | -2222 | -3830 |
| MRPS35 | -4450 | 3080 | -2647 | 954 |
| MRPS36 | -5429 | -2678 | 682 | -3208 |
| MRPS5 | -3273 | -1161 | -2766 | -5089 |
| MRPS6 | 1135 | -4408 | 2857 | -486 |
| MRPS7 | -3579 | -1321 | 849 | 138 |
| MRPS9 | -3785 | 1389 | -4076 | -1007 |
| MRRF | -2365 | -2758 | -206 | -1218 |
| MTRF1L | -5397 | 1502 | -3819 | -3157 |
| OXA1L | -4632 | -2587 | -3906 | -3044 |
| PTCD3 | -5161 | 3456 | -5112 | -4052 |
Mitochondrial translation elongation
| metric | value |
|---|---|
| setSize | 81 |
| pMANOVA | 1.59e-17 |
| p.adjustMANOVA | 8.47e-16 |
| s.dist | 0.753 |
| s.FSHD | -0.542 |
| s.hu_model | 0.159 |
| s.Watt_m | -0.297 |
| s.Jones_m | -0.399 |
| p.FSHD | 3.57e-17 |
| p.hu_model | 0.0137 |
| p.Watt_m | 3.81e-06 |
| p.Jones_m | 5.7e-10 |
| Gene | FSHD | Jones_m |
|---|---|---|
| GFM1 | -5327 | -4196 |
| PTCD3 | -5161 | -4052 |
| DAP3 | -4837 | -4034 |
| MRPL30 | -4564 | -4158 |
| MRPL42 | -3577 | -5202 |
| MRPS36 | -5429 | -3208 |
| MRPL32 | -4818 | -3602 |
| MRPS18B | -4367 | -3831 |
| MRPS5 | -3273 | -5089 |
| CHCHD1 | -3980 | -3974 |
| MRPL16 | -4392 | -3597 |
| MRPL11 | -3720 | -4218 |
| TUFM | -3802 | -4101 |
| MRPS16 | -4590 | -3231 |
| MRPS15 | -3628 | -4018 |
| MRPS23 | -4659 | -3082 |
| OXA1L | -4632 | -3044 |
| MRPS27 | -4915 | -2848 |
| MRPL35 | -5028 | -2768 |
| MRPS28 | -2816 | -4916 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AURKAIP1 | -3378 | -2276 | -1747 | -3524 |
| CHCHD1 | -3980 | -540 | -1809 | -3974 |
| DAP3 | -4837 | -461 | 2611 | -4034 |
| ERAL1 | -3167 | 2585 | -858 | -3141 |
| GADD45GIP1 | -1089 | -2386 | -3149 | -2950 |
| GFM1 | -5327 | 4168 | -4357 | -4196 |
| MRPL1 | -3901 | -1280 | -4021 | -2985 |
| MRPL10 | -2288 | -2374 | -4353 | -2443 |
| MRPL11 | -3720 | 2077 | -2512 | -4218 |
| MRPL12 | -1963 | -2623 | -2727 | -2667 |
| MRPL13 | -3539 | 343 | 285 | -3672 |
| MRPL14 | -1974 | -1679 | -1052 | 1359 |
| MRPL15 | -3132 | 2448 | -2949 | -4325 |
| MRPL16 | -4392 | 3057 | -3392 | -3597 |
| MRPL17 | 595 | 1912 | 2816 | 4209 |
| MRPL18 | -2407 | 2971 | -4191 | -3349 |
| MRPL19 | -4475 | 4046 | -3671 | -1186 |
| MRPL2 | -2747 | -435 | -1567 | -4868 |
| MRPL20 | -3024 | 531 | 207 | -510 |
| MRPL21 | -3086 | 1674 | -768 | -3347 |
| MRPL22 | -2171 | 3326 | -2754 | -3733 |
| MRPL23 | -3087 | -3178 | -776 | -1241 |
| MRPL24 | -1464 | -1858 | -2181 | -1722 |
| MRPL27 | -2722 | -1594 | -1652 | -1044 |
| MRPL28 | -7 | -271 | -990 | -2552 |
| MRPL3 | -3854 | 2949 | -3937 | -192 |
| MRPL30 | -4564 | 3470 | -1084 | -4158 |
| MRPL32 | -4818 | 3042 | 2692 | -3602 |
| MRPL34 | -3944 | -2159 | -3284 | -2255 |
| MRPL35 | -5028 | 800 | -2563 | -2768 |
| MRPL36 | -2568 | -557 | -2264 | 625 |
| MRPL37 | -2913 | 1590 | -2744 | -3921 |
| MRPL38 | -490 | 368 | -1753 | -3644 |
| MRPL39 | -3867 | 2569 | -947 | -1196 |
| MRPL4 | -1740 | 2929 | -505 | -2748 |
| MRPL40 | -2857 | -249 | 796 | 637 |
| MRPL41 | -4483 | -4838 | -1856 | 1777 |
| MRPL42 | -3577 | 2087 | -1650 | -5202 |
| MRPL43 | -1019 | -1428 | -663 | 1286 |
| MRPL44 | -3543 | 4365 | -2069 | -3706 |
| MRPL46 | -2332 | 996 | -440 | 1568 |
| MRPL47 | -1558 | 3146 | -1887 | -1504 |
| MRPL48 | -3651 | -80 | 163 | -1871 |
| MRPL49 | -468 | 4723 | -3219 | -2978 |
| MRPL50 | -3974 | 3074 | -150 | -1267 |
| MRPL51 | -2492 | -387 | -1581 | -4128 |
| MRPL52 | -1075 | -2282 | 1466 | -1004 |
| MRPL54 | 445 | -1970 | 2366 | -2983 |
| MRPL55 | -932 | 1077 | -3210 | -3400 |
| MRPL9 | -2162 | 3406 | -3593 | -1971 |
| MRPS10 | -2227 | -3045 | -784 | -2392 |
| MRPS11 | -3081 | 280 | -2798 | -1751 |
| MRPS12 | -2364 | -146 | 616 | 1122 |
| MRPS14 | -1834 | 1778 | -4387 | -4044 |
| MRPS15 | -3628 | 1857 | -1464 | -4018 |
| MRPS16 | -4590 | 1192 | -2229 | -3231 |
| MRPS17 | -3181 | -131 | -1389 | 4388 |
| MRPS18A | -2481 | 465 | -4081 | -4980 |
| MRPS18B | -4367 | -1848 | 1877 | -3831 |
| MRPS18C | -3506 | 4342 | -675 | -570 |
| MRPS2 | -2046 | 1425 | 2175 | -19 |
| MRPS22 | -4388 | 4344 | -1949 | -275 |
| MRPS23 | -4659 | 1657 | -4044 | -3082 |
| MRPS25 | -3226 | -3514 | -3925 | 431 |
| MRPS26 | -646 | -610 | -1343 | -2703 |
| MRPS27 | -4915 | 555 | -2134 | -2848 |
| MRPS28 | -2816 | 1341 | -1288 | -4916 |
| MRPS30 | -3672 | 3442 | 761 | -2570 |
| MRPS31 | -4207 | 3479 | -1758 | -2995 |
| MRPS33 | -4017 | 149 | -530 | -1199 |
| MRPS34 | -2775 | -3797 | -2222 | -3830 |
| MRPS35 | -4450 | 3080 | -2647 | 954 |
| MRPS36 | -5429 | -2678 | 682 | -3208 |
| MRPS5 | -3273 | -1161 | -2766 | -5089 |
| MRPS6 | 1135 | -4408 | 2857 | -486 |
| MRPS7 | -3579 | -1321 | 849 | 138 |
| MRPS9 | -3785 | 1389 | -4076 | -1007 |
| OXA1L | -4632 | -2587 | -3906 | -3044 |
| PTCD3 | -5161 | 3456 | -5112 | -4052 |
| TSFM | -3801 | 1946 | -2884 | 3728 |
| TUFM | -3802 | -2555 | -3791 | -4101 |
Gluconeogenesis
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 1.67e-05 |
| p.adjustMANOVA | 9.17e-05 |
| s.dist | 0.749 |
| s.FSHD | -0.0701 |
| s.hu_model | -0.555 |
| s.Watt_m | -0.352 |
| s.Jones_m | -0.352 |
| p.FSHD | 0.578 |
| p.hu_model | 1.06e-05 |
| p.Watt_m | 0.00528 |
| p.Jones_m | 0.00523 |
| Gene | hu_model | Watt_m |
|---|---|---|
| SLC25A12 | -5285 | -4498 |
| SLC37A4 | -4706 | -4997 |
| GPI | -5148 | -4088 |
| ALDOA | -5511 | -3443 |
| PC | -5164 | -3656 |
| SLC25A11 | -4056 | -3802 |
| TPI1 | -3331 | -4427 |
| ENO3 | -4611 | -2827 |
| MDH2 | -4307 | -2826 |
| GOT2 | -3657 | -3058 |
| FBP2 | -3279 | -3190 |
| PGK1 | -1397 | -3476 |
| GOT1 | -3709 | -1241 |
| G6PC3 | -3026 | -1478 |
| MDH1 | -1078 | -3603 |
| SLC37A1 | -2557 | -200 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ALDOA | -3976 | -5511 | -3443 | -5047 |
| ENO1 | 5029 | -4031 | 2449 | 4819 |
| ENO2 | 4873 | -1995 | 892 | 3627 |
| ENO3 | -2016 | -4611 | -2827 | -4496 |
| FBP2 | -598 | -3279 | -3190 | -5287 |
| G6PC3 | 1060 | -3026 | -1478 | -3910 |
| GOT1 | -2290 | -3709 | -1241 | -66 |
| GOT2 | -3182 | -3657 | -3058 | -2419 |
| GPI | -4196 | -5148 | -4088 | -3489 |
| MDH1 | -3312 | -1078 | -3603 | -1356 |
| MDH2 | -2694 | -4307 | -2826 | -2711 |
| PC | 929 | -5164 | -3656 | -4683 |
| PCK2 | 4447 | -2285 | 369 | 3424 |
| PGK1 | -2419 | -1397 | -3476 | -4681 |
| SLC25A1 | 4153 | -2654 | 3689 | -1464 |
| SLC25A11 | -3036 | -4056 | -3802 | -2638 |
| SLC25A12 | -3491 | -5285 | -4498 | -4932 |
| SLC25A13 | 1610 | 4248 | 3565 | 3923 |
| SLC37A1 | 1964 | -2557 | -200 | 1128 |
| SLC37A4 | -3004 | -4706 | -4997 | -4920 |
| TPI1 | -1402 | -3331 | -4427 | -4455 |
Integrin cell surface interactions
| metric | value |
|---|---|
| setSize | 45 |
| pMANOVA | 1.02e-11 |
| p.adjustMANOVA | 1.98e-10 |
| s.dist | 0.748 |
| s.FSHD | 0.599 |
| s.hu_model | -0.231 |
| s.Watt_m | 0.0965 |
| s.Jones_m | 0.372 |
| p.FSHD | 3.67e-12 |
| p.hu_model | 0.00731 |
| p.Watt_m | 0.263 |
| p.Jones_m | 1.63e-05 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SPP1 | 4998 | 5215 |
| ITGB2 | 4906 | 5102 |
| CD44 | 4845 | 5080 |
| ITGAM | 4572 | 5107 |
| VCAM1 | 4924 | 4588 |
| ICAM1 | 4641 | 4600 |
| LUM | 4580 | 4537 |
| FN1 | 4783 | 4002 |
| ITGA5 | 4033 | 4594 |
| THBS1 | 4954 | 3647 |
| TNC | 5019 | 3460 |
| ITGA9 | 4154 | 3909 |
| CD47 | 3471 | 4552 |
| FBN1 | 4504 | 2988 |
| COL18A1 | 4351 | 3090 |
| COL4A2 | 3851 | 3295 |
| COL4A1 | 3805 | 3236 |
| ITGB3 | 3693 | 2921 |
| ITGAX | 1897 | 5125 |
| COL16A1 | 3846 | 2475 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| BSG | -1369 | -2217 | -2093 | -5147 |
| CD44 | 4845 | 826 | 4939 | 5080 |
| CD47 | 3471 | -2154 | 2654 | 4552 |
| COL13A1 | -180 | -2295 | -1942 | 1914 |
| COL16A1 | 3846 | -2915 | 1643 | 2475 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL23A1 | 3199 | -4585 | -845 | 2418 |
| COL4A1 | 3805 | -4695 | 688 | 3236 |
| COL4A2 | 3851 | -4973 | 861 | 3295 |
| COL4A3 | -2253 | -3782 | -4833 | -1934 |
| COL4A4 | -2804 | -2983 | -3940 | -28 |
| COMP | 5024 | 275 | -1007 | -884 |
| F11R | 3414 | -2271 | -667 | -1517 |
| FBN1 | 4504 | 636 | 3601 | 2988 |
| FN1 | 4783 | 33 | 3978 | 4002 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| ICAM1 | 4641 | 1044 | 4128 | 4600 |
| ICAM2 | 1999 | -1485 | -3439 | -639 |
| ITGA1 | 1435 | 1740 | -4092 | -3028 |
| ITGA10 | 4023 | -1852 | -979 | -1086 |
| ITGA11 | 4615 | -1000 | -2691 | 1284 |
| ITGA3 | 4809 | -5450 | 2976 | 557 |
| ITGA4 | 2431 | -2840 | -5085 | 1443 |
| ITGA5 | 4033 | -4692 | 5127 | 4594 |
| ITGA6 | 1799 | -990 | -5243 | -114 |
| ITGA7 | 580 | -4661 | 2121 | -4020 |
| ITGA8 | 1156 | 4577 | 93 | 2702 |
| ITGA9 | 4154 | -5185 | 3041 | 3909 |
| ITGAM | 4572 | -2599 | 4997 | 5107 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGAX | 1897 | -886 | 3808 | 5125 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB2 | 4906 | -107 | 4945 | 5102 |
| ITGB3 | 3693 | -485 | 4867 | 2921 |
| ITGB5 | 3604 | -2545 | -4743 | -4839 |
| ITGB6 | -3832 | 471 | -3693 | 4890 |
| ITGB8 | 4079 | 3217 | -2411 | 711 |
| JAM2 | 3444 | -5266 | -4961 | -2840 |
| JAM3 | 4578 | 1269 | -3928 | 1313 |
| LUM | 4580 | -1815 | 2455 | 4537 |
| SPP1 | 4998 | 1150 | 3009 | 5215 |
| THBS1 | 4954 | 752 | 4384 | 3647 |
| TNC | 5019 | 793 | 4283 | 3460 |
| VCAM1 | 4924 | 2842 | 4665 | 4588 |
CS/DS degradation
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.02 |
| p.adjustMANOVA | 0.0418 |
| s.dist | 0.746 |
| s.FSHD | 0.474 |
| s.hu_model | -0.265 |
| s.Watt_m | 0.163 |
| s.Jones_m | 0.485 |
| p.FSHD | 0.00943 |
| p.hu_model | 0.147 |
| p.Watt_m | 0.372 |
| p.Jones_m | 0.00789 |
| Gene | Jones_m | FSHD |
|---|---|---|
| BGN | 5088 | 4348 |
| VCAN | 4285 | 4971 |
| HEXB | 4889 | 2661 |
| HEXA | 4440 | 2020 |
| IDS | 4417 | 1662 |
| ARSB | 3584 | 471 |
| IDUA | 75 | 4027 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ARSB | 471 | -989 | 2803 | 3584 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| HEXA | 2020 | -220 | 1726 | 4440 |
| HEXB | 2661 | 743 | 2355 | 4889 |
| HYAL1 | -5197 | -3796 | 1588 | 129 |
| IDS | 1662 | -2441 | -3581 | 4417 |
| IDUA | 4027 | -3817 | -4684 | 75 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Sema3A PAK dependent Axon repulsion
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00333 |
| p.adjustMANOVA | 0.00954 |
| s.dist | 0.746 |
| s.FSHD | 0.315 |
| s.hu_model | -0.183 |
| s.Watt_m | 0.392 |
| s.Jones_m | 0.52 |
| p.FSHD | 0.0346 |
| p.hu_model | 0.22 |
| p.Watt_m | 0.00857 |
| p.Jones_m | 0.000495 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| CFL1 | 4792 | 4672 |
| HSP90AA1 | 4248 | 5204 |
| FES | 4746 | 4465 |
| PAK2 | 3813 | 4757 |
| LIMK1 | 3639 | 4130 |
| FYN | 4010 | 3642 |
| PLXNA3 | 2143 | 3020 |
| SEMA3A | 4313 | 1054 |
| HSP90AB1 | 723 | 4582 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CFL1 | 3939 | -898 | 4672 | 4792 |
| FES | 4554 | 551 | 4465 | 4746 |
| FYN | 4466 | -2813 | 3642 | 4010 |
| HSP90AA1 | -961 | 3627 | 5204 | 4248 |
| HSP90AB1 | -1913 | -636 | 4582 | 723 |
| LIMK1 | 260 | -4797 | 4130 | 3639 |
| NRP1 | 3290 | -112 | -4213 | 1660 |
| PAK1 | 181 | -5356 | -4830 | 1730 |
| PAK2 | 648 | 1508 | 4757 | 3813 |
| PLXNA1 | 1173 | -4429 | -533 | 4647 |
| PLXNA2 | 1233 | -5329 | 3681 | -1661 |
| PLXNA3 | 3786 | -5050 | 3020 | 2143 |
| PLXNA4 | -1934 | -318 | -836 | 2286 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| SEMA3A | 3892 | 2659 | 1054 | 4313 |
Phase 0 - rapid depolarisation
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 7.93e-05 |
| p.adjustMANOVA | 0.000375 |
| s.dist | 0.746 |
| s.FSHD | -0.074 |
| s.hu_model | -0.622 |
| s.Watt_m | -0.26 |
| s.Jones_m | -0.31 |
| p.FSHD | 0.598 |
| p.hu_model | 8.98e-06 |
| p.Watt_m | 0.0635 |
| p.Jones_m | 0.0269 |
| Gene | hu_model | Jones_m |
|---|---|---|
| CACNG6 | -5214 | -5152 |
| CAMK2B | -5433 | -4601 |
| SCN1B | -4839 | -5072 |
| SCN4A | -5537 | -4415 |
| CACNB1 | -5223 | -4634 |
| CAMK2A | -5463 | -4357 |
| CALM1 | -4406 | -3365 |
| RANGRF | -3968 | -3463 |
| CAMK2G | -2068 | -5073 |
| SCN3B | -3842 | -1746 |
| SCN2B | -4214 | -656 |
| CACNA1C | -758 | -673 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CACNA1C | 2297 | -758 | -662 | -673 |
| CACNB1 | -227 | -5223 | -5290 | -4634 |
| CACNG6 | -798 | -5214 | -4502 | -5152 |
| CALM1 | 591 | -4406 | 95 | -3365 |
| CAMK2A | -839 | -5463 | -4382 | -4357 |
| CAMK2B | -1020 | -5433 | -4185 | -4601 |
| CAMK2D | 210 | -2193 | 4093 | 4423 |
| CAMK2G | -5165 | -2068 | -4907 | -5073 |
| FGF11 | 805 | -3846 | -3695 | 1142 |
| FGF13 | -3421 | -836 | 608 | 3908 |
| RANGRF | 2572 | -3968 | 155 | -3463 |
| SCN1B | -2988 | -4839 | -5256 | -5072 |
| SCN2B | -2156 | -4214 | -1901 | -656 |
| SCN3A | 406 | 2417 | 4375 | 661 |
| SCN3B | 889 | -3842 | 2946 | -1746 |
| SCN4A | -3428 | -5537 | -5031 | -4415 |
| SCN5A | 2570 | -5247 | 3478 | 4731 |
Chondroitin sulfate/dermatan sulfate metabolism
| metric | value |
|---|---|
| setSize | 37 |
| pMANOVA | 1.73e-08 |
| p.adjustMANOVA | 1.82e-07 |
| s.dist | 0.744 |
| s.FSHD | 0.566 |
| s.hu_model | -0.226 |
| s.Watt_m | 0.194 |
| s.Jones_m | 0.38 |
| p.FSHD | 2.58e-09 |
| p.hu_model | 0.0173 |
| p.Watt_m | 0.0415 |
| p.Jones_m | 6.48e-05 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SDC2 | 4456 | 5008 |
| BGN | 4348 | 5088 |
| VCAN | 4971 | 4285 |
| SDC3 | 3721 | 4191 |
| CHSY1 | 4080 | 3666 |
| DSEL | 4639 | 3188 |
| CHST11 | 4013 | 3364 |
| HEXB | 2661 | 4889 |
| CHPF2 | 4430 | 2836 |
| CSGALNACT1 | 3780 | 3223 |
| B3GALT6 | 3823 | 3103 |
| CHPF | 4271 | 2760 |
| DSE | 2330 | 4865 |
| CHST14 | 3538 | 3049 |
| SDC1 | 3944 | 2683 |
| UST | 4297 | 2114 |
| HEXA | 2020 | 4440 |
| IDS | 1662 | 4417 |
| HSPG2 | 2035 | 2942 |
| CHST15 | 4124 | 1275 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| ARSB | 471 | -989 | 2803 | 3584 |
| B3GALT6 | 3823 | -1236 | 4092 | 3103 |
| B3GAT3 | 4055 | -4180 | 1326 | -1191 |
| B4GALT7 | 746 | -4099 | -1523 | 513 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CHPF | 4271 | -4389 | 1240 | 2760 |
| CHPF2 | 4430 | -2038 | 2362 | 2836 |
| CHST11 | 4013 | -183 | 2253 | 3364 |
| CHST12 | 125 | -1250 | 1266 | 1673 |
| CHST14 | 3538 | -3780 | 1229 | 3049 |
| CHST15 | 4124 | -4640 | -3177 | 1275 |
| CHST7 | 3877 | 2707 | -1313 | -269 |
| CHSY1 | 4080 | 3773 | 1890 | 3666 |
| CSGALNACT1 | 3780 | -204 | 2536 | 3223 |
| CSGALNACT2 | 561 | 1490 | 3991 | 480 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| DSE | 2330 | 3355 | 2098 | 4865 |
| DSEL | 4639 | 4198 | 923 | 3188 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HEXA | 2020 | -220 | 1726 | 4440 |
| HEXB | 2661 | 743 | 2355 | 4889 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| HYAL1 | -5197 | -3796 | 1588 | 129 |
| IDS | 1662 | -2441 | -3581 | 4417 |
| IDUA | 4027 | -3817 | -4684 | 75 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| UST | 4297 | 988 | 1404 | 2114 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
| XYLT1 | 3695 | 2589 | 2917 | -2537 |
| XYLT2 | 2228 | -1124 | 1315 | 1093 |
Elastic fibre formation
| metric | value |
|---|---|
| setSize | 34 |
| pMANOVA | 1.94e-07 |
| p.adjustMANOVA | 1.82e-06 |
| s.dist | 0.743 |
| s.FSHD | 0.588 |
| s.hu_model | -0.0405 |
| s.Watt_m | 0.28 |
| s.Jones_m | 0.356 |
| p.FSHD | 2.98e-09 |
| p.hu_model | 0.683 |
| p.Watt_m | 0.00482 |
| p.Jones_m | 0.000336 |
| Gene | FSHD | Jones_m |
|---|---|---|
| LOXL3 | 4563 | 4925 |
| MFAP5 | 4668 | 4499 |
| LOXL1 | 4187 | 4524 |
| ITGA5 | 4033 | 4594 |
| LOXL2 | 5054 | 3520 |
| LOX | 4606 | 3765 |
| TGFB1 | 4177 | 4099 |
| FBLN2 | 3856 | 4216 |
| FBN1 | 4504 | 2988 |
| LOXL4 | 3456 | 3757 |
| MFAP4 | 4643 | 2564 |
| ITGB3 | 3693 | 2921 |
| MFAP2 | 4871 | 2158 |
| ELN | 4832 | 1614 |
| EFEMP2 | 1698 | 4207 |
| ITGB1 | 891 | 4783 |
| ITGAV | 801 | 4981 |
| ITGA8 | 1156 | 2702 |
| ITGB8 | 4079 | 711 |
| LTBP1 | 555 | 4963 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| BMP2 | 3157 | -4202 | 820 | -1673 |
| BMP4 | 2116 | 329 | 908 | 307 |
| EFEMP1 | 4878 | 1197 | 2548 | -562 |
| EFEMP2 | 1698 | -4478 | 2866 | 4207 |
| ELN | 4832 | -4996 | -384 | 1614 |
| FBLN1 | 4502 | -1609 | 1591 | -376 |
| FBLN2 | 3856 | -641 | 3313 | 4216 |
| FBLN5 | 3811 | 1519 | -1289 | -1272 |
| FBN1 | 4504 | 636 | 3601 | 2988 |
| FURIN | 1239 | -4167 | 4073 | -1204 |
| ITGA5 | 4033 | -4692 | 5127 | 4594 |
| ITGA8 | 1156 | 4577 | 93 | 2702 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB3 | 3693 | -485 | 4867 | 2921 |
| ITGB5 | 3604 | -2545 | -4743 | -4839 |
| ITGB6 | -3832 | 471 | -3693 | 4890 |
| ITGB8 | 4079 | 3217 | -2411 | 711 |
| LOX | 4606 | 4062 | 3160 | 3765 |
| LOXL1 | 4187 | -1569 | 3956 | 4524 |
| LOXL2 | 5054 | -3017 | 2997 | 3520 |
| LOXL3 | 4563 | -1100 | 1944 | 4925 |
| LOXL4 | 3456 | 552 | 27 | 3757 |
| LTBP1 | 555 | -67 | -1267 | 4963 |
| LTBP3 | 2480 | -3134 | -2528 | -990 |
| LTBP4 | 3682 | -1659 | 2214 | 400 |
| MFAP1 | -2124 | 4892 | 3769 | -1986 |
| MFAP2 | 4871 | 78 | 422 | 2158 |
| MFAP3 | -1951 | 4029 | 2831 | 3634 |
| MFAP4 | 4643 | -755 | -329 | 2564 |
| MFAP5 | 4668 | -121 | 4486 | 4499 |
| TGFB1 | 4177 | -3070 | 4895 | 4099 |
| TGFB2 | 3078 | 4561 | 1841 | -2330 |
| TGFB3 | 3860 | -5264 | -2015 | -4211 |
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00536 |
| p.adjustMANOVA | 0.0141 |
| s.dist | 0.743 |
| s.FSHD | 0.441 |
| s.hu_model | -0.215 |
| s.Watt_m | 0.257 |
| s.Jones_m | 0.495 |
| p.FSHD | 0.00432 |
| p.hu_model | 0.163 |
| p.Watt_m | 0.0967 |
| p.Jones_m | 0.00134 |
| Gene | Jones_m | FSHD |
|---|---|---|
| FES | 4746 | 4554 |
| FYN | 4010 | 4466 |
| SEMA3A | 4313 | 3892 |
| RRAS | 4281 | 3554 |
| TLN1 | 4067 | 2279 |
| PLXNA3 | 2143 | 3786 |
| RND1 | 4014 | 2013 |
| NRP1 | 1660 | 3290 |
| PLXNA1 | 4647 | 1173 |
| PIP5K1C | 2520 | 1931 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| FARP2 | 137 | -1317 | -3360 | -426 |
| FES | 4554 | 551 | 4465 | 4746 |
| FYN | 4466 | -2813 | 3642 | 4010 |
| NRP1 | 3290 | -112 | -4213 | 1660 |
| PIP5K1C | 1931 | -1891 | 384 | 2520 |
| PLXNA1 | 1173 | -4429 | -533 | 4647 |
| PLXNA2 | 1233 | -5329 | 3681 | -1661 |
| PLXNA3 | 3786 | -5050 | 3020 | 2143 |
| PLXNA4 | -1934 | -318 | -836 | 2286 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| RND1 | 2013 | 3850 | 5209 | 4014 |
| RRAS | 3554 | -4446 | 1337 | 4281 |
| SEMA3A | 3892 | 2659 | 1054 | 4313 |
| TLN1 | 2279 | -3868 | 2941 | 4067 |
Regulation of Complement cascade
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.000347 |
| p.adjustMANOVA | 0.00136 |
| s.dist | 0.741 |
| s.FSHD | 0.652 |
| s.hu_model | 0.0474 |
| s.Watt_m | -0.00954 |
| s.Jones_m | 0.348 |
| p.FSHD | 4.68e-05 |
| p.hu_model | 0.767 |
| p.Watt_m | 0.953 |
| p.Jones_m | 0.0297 |
| Gene | FSHD | Jones_m |
|---|---|---|
| C1S | 5050 | 4323 |
| C1R | 4829 | 4496 |
| CFH | 5027 | 4077 |
| SERPING1 | 4526 | 4253 |
| C3 | 4737 | 4049 |
| CD81 | 4123 | 4155 |
| PROS1 | 3701 | 4200 |
| C2 | 5030 | 2346 |
| C7 | 4661 | 832 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| C1R | 4829 | -806 | -1012 | 4496 |
| C1S | 5050 | -2395 | -2030 | 4323 |
| C2 | 5030 | -555 | -1347 | 2346 |
| C3 | 4737 | 4276 | 1818 | 4049 |
| C7 | 4661 | -1115 | 1322 | 832 |
| CD46 | 540 | 1526 | -3448 | -2924 |
| CD55 | 1172 | 217 | -321 | -3953 |
| CD59 | -5248 | 1620 | -4331 | 1749 |
| CD81 | 4123 | -4615 | 886 | 4155 |
| CFH | 5027 | -553 | -114 | 4077 |
| CLU | 4108 | 1612 | 4120 | -4236 |
| PROS1 | 3701 | 100 | 2906 | 4200 |
| SERPING1 | 4526 | 75 | 281 | 4253 |
Mitochondrial translation initiation
| metric | value |
|---|---|
| setSize | 81 |
| pMANOVA | 4.72e-17 |
| p.adjustMANOVA | 2.15e-15 |
| s.dist | 0.74 |
| s.FSHD | -0.54 |
| s.hu_model | 0.152 |
| s.Watt_m | -0.291 |
| s.Jones_m | -0.385 |
| p.FSHD | 4.46e-17 |
| p.hu_model | 0.0184 |
| p.Watt_m | 6.38e-06 |
| p.Jones_m | 2.12e-09 |
| Gene | FSHD | Jones_m |
|---|---|---|
| PTCD3 | -5161 | -4052 |
| DAP3 | -4837 | -4034 |
| MRPL30 | -4564 | -4158 |
| MRPL42 | -3577 | -5202 |
| MRPS36 | -5429 | -3208 |
| MRPL32 | -4818 | -3602 |
| MTIF2 | -4920 | -3415 |
| MRPS18B | -4367 | -3831 |
| MRPS5 | -3273 | -5089 |
| CHCHD1 | -3980 | -3974 |
| MRPL16 | -4392 | -3597 |
| MRPL11 | -3720 | -4218 |
| MRPS16 | -4590 | -3231 |
| MRPS15 | -3628 | -4018 |
| MRPS23 | -4659 | -3082 |
| OXA1L | -4632 | -3044 |
| MRPS27 | -4915 | -2848 |
| MRPL35 | -5028 | -2768 |
| MRPS28 | -2816 | -4916 |
| MRPL15 | -3132 | -4325 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AURKAIP1 | -3378 | -2276 | -1747 | -3524 |
| CHCHD1 | -3980 | -540 | -1809 | -3974 |
| DAP3 | -4837 | -461 | 2611 | -4034 |
| ERAL1 | -3167 | 2585 | -858 | -3141 |
| GADD45GIP1 | -1089 | -2386 | -3149 | -2950 |
| MRPL1 | -3901 | -1280 | -4021 | -2985 |
| MRPL10 | -2288 | -2374 | -4353 | -2443 |
| MRPL11 | -3720 | 2077 | -2512 | -4218 |
| MRPL12 | -1963 | -2623 | -2727 | -2667 |
| MRPL13 | -3539 | 343 | 285 | -3672 |
| MRPL14 | -1974 | -1679 | -1052 | 1359 |
| MRPL15 | -3132 | 2448 | -2949 | -4325 |
| MRPL16 | -4392 | 3057 | -3392 | -3597 |
| MRPL17 | 595 | 1912 | 2816 | 4209 |
| MRPL18 | -2407 | 2971 | -4191 | -3349 |
| MRPL19 | -4475 | 4046 | -3671 | -1186 |
| MRPL2 | -2747 | -435 | -1567 | -4868 |
| MRPL20 | -3024 | 531 | 207 | -510 |
| MRPL21 | -3086 | 1674 | -768 | -3347 |
| MRPL22 | -2171 | 3326 | -2754 | -3733 |
| MRPL23 | -3087 | -3178 | -776 | -1241 |
| MRPL24 | -1464 | -1858 | -2181 | -1722 |
| MRPL27 | -2722 | -1594 | -1652 | -1044 |
| MRPL28 | -7 | -271 | -990 | -2552 |
| MRPL3 | -3854 | 2949 | -3937 | -192 |
| MRPL30 | -4564 | 3470 | -1084 | -4158 |
| MRPL32 | -4818 | 3042 | 2692 | -3602 |
| MRPL34 | -3944 | -2159 | -3284 | -2255 |
| MRPL35 | -5028 | 800 | -2563 | -2768 |
| MRPL36 | -2568 | -557 | -2264 | 625 |
| MRPL37 | -2913 | 1590 | -2744 | -3921 |
| MRPL38 | -490 | 368 | -1753 | -3644 |
| MRPL39 | -3867 | 2569 | -947 | -1196 |
| MRPL4 | -1740 | 2929 | -505 | -2748 |
| MRPL40 | -2857 | -249 | 796 | 637 |
| MRPL41 | -4483 | -4838 | -1856 | 1777 |
| MRPL42 | -3577 | 2087 | -1650 | -5202 |
| MRPL43 | -1019 | -1428 | -663 | 1286 |
| MRPL44 | -3543 | 4365 | -2069 | -3706 |
| MRPL46 | -2332 | 996 | -440 | 1568 |
| MRPL47 | -1558 | 3146 | -1887 | -1504 |
| MRPL48 | -3651 | -80 | 163 | -1871 |
| MRPL49 | -468 | 4723 | -3219 | -2978 |
| MRPL50 | -3974 | 3074 | -150 | -1267 |
| MRPL51 | -2492 | -387 | -1581 | -4128 |
| MRPL52 | -1075 | -2282 | 1466 | -1004 |
| MRPL54 | 445 | -1970 | 2366 | -2983 |
| MRPL55 | -932 | 1077 | -3210 | -3400 |
| MRPL9 | -2162 | 3406 | -3593 | -1971 |
| MRPS10 | -2227 | -3045 | -784 | -2392 |
| MRPS11 | -3081 | 280 | -2798 | -1751 |
| MRPS12 | -2364 | -146 | 616 | 1122 |
| MRPS14 | -1834 | 1778 | -4387 | -4044 |
| MRPS15 | -3628 | 1857 | -1464 | -4018 |
| MRPS16 | -4590 | 1192 | -2229 | -3231 |
| MRPS17 | -3181 | -131 | -1389 | 4388 |
| MRPS18A | -2481 | 465 | -4081 | -4980 |
| MRPS18B | -4367 | -1848 | 1877 | -3831 |
| MRPS18C | -3506 | 4342 | -675 | -570 |
| MRPS2 | -2046 | 1425 | 2175 | -19 |
| MRPS22 | -4388 | 4344 | -1949 | -275 |
| MRPS23 | -4659 | 1657 | -4044 | -3082 |
| MRPS25 | -3226 | -3514 | -3925 | 431 |
| MRPS26 | -646 | -610 | -1343 | -2703 |
| MRPS27 | -4915 | 555 | -2134 | -2848 |
| MRPS28 | -2816 | 1341 | -1288 | -4916 |
| MRPS30 | -3672 | 3442 | 761 | -2570 |
| MRPS31 | -4207 | 3479 | -1758 | -2995 |
| MRPS33 | -4017 | 149 | -530 | -1199 |
| MRPS34 | -2775 | -3797 | -2222 | -3830 |
| MRPS35 | -4450 | 3080 | -2647 | 954 |
| MRPS36 | -5429 | -2678 | 682 | -3208 |
| MRPS5 | -3273 | -1161 | -2766 | -5089 |
| MRPS6 | 1135 | -4408 | 2857 | -486 |
| MRPS7 | -3579 | -1321 | 849 | 138 |
| MRPS9 | -3785 | 1389 | -4076 | -1007 |
| MTFMT | -3046 | -1437 | -1940 | 1267 |
| MTIF2 | -4920 | 1787 | -4751 | -3415 |
| MTIF3 | -4258 | 276 | -1404 | 3305 |
| OXA1L | -4632 | -2587 | -3906 | -3044 |
| PTCD3 | -5161 | 3456 | -5112 | -4052 |
Formation of tubulin folding intermediates by CCT/TriC
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 1.34e-05 |
| p.adjustMANOVA | 7.63e-05 |
| s.dist | 0.739 |
| s.FSHD | 0.0756 |
| s.hu_model | -0.0946 |
| s.Watt_m | 0.683 |
| s.Jones_m | 0.255 |
| p.FSHD | 0.589 |
| p.hu_model | 0.5 |
| p.Watt_m | 1.07e-06 |
| p.Jones_m | 0.0691 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| TUBB6 | 5153 | 5168 |
| TUBA1C | 5075 | 5010 |
| TUBA1B | 4866 | 4967 |
| TUBB2B | 4912 | 4788 |
| TUBB2A | 4401 | 4710 |
| TUBA1A | 3672 | 3786 |
| TUBB4B | 4848 | 2861 |
| CCT4 | 3292 | 2174 |
| CCT3 | 4860 | 1411 |
| CCT8 | 3753 | 1167 |
| CCT2 | 4163 | 506 |
| TCP1 | 1199 | 59 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CCT2 | -566 | 3774 | 4163 | 506 |
| CCT3 | -62 | 2307 | 4860 | 1411 |
| CCT4 | -1655 | 939 | 3292 | 2174 |
| CCT5 | -813 | 3048 | 2610 | -2806 |
| CCT6A | -3336 | 2908 | 3000 | -3352 |
| CCT7 | -2416 | 432 | 3340 | -2045 |
| CCT8 | -2093 | 4116 | 3753 | 1167 |
| TCP1 | -4260 | 4443 | 1199 | 59 |
| TUBA1A | 4948 | -5166 | 3672 | 3786 |
| TUBA1B | 4448 | -5262 | 4866 | 4967 |
| TUBA1C | 3088 | -4823 | 5075 | 5010 |
| TUBA4A | -2112 | -5280 | 2049 | -3253 |
| TUBA8 | -2556 | -1103 | -882 | -2976 |
| TUBB2A | 2970 | -4616 | 4401 | 4710 |
| TUBB2B | 2381 | -4644 | 4912 | 4788 |
| TUBB4B | 776 | 426 | 4848 | 2861 |
| TUBB6 | 4937 | -4998 | 5153 | 5168 |
Binding and Uptake of Ligands by Scavenger Receptors
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 3.26e-05 |
| p.adjustMANOVA | 0.000167 |
| s.dist | 0.737 |
| s.FSHD | 0.555 |
| s.hu_model | -0.152 |
| s.Watt_m | 0.157 |
| s.Jones_m | 0.433 |
| p.FSHD | 4.15e-06 |
| p.hu_model | 0.208 |
| p.Watt_m | 0.192 |
| p.Jones_m | 0.00033 |
| Gene | FSHD | Jones_m |
|---|---|---|
| MSR1 | 5020 | 4999 |
| APOE | 3947 | 4717 |
| CALR | 3782 | 4356 |
| COL3A1 | 4565 | 3575 |
| LRP1 | 4481 | 3531 |
| HSP90B1 | 3464 | 4544 |
| COLEC12 | 4753 | 3221 |
| COL4A2 | 3851 | 3295 |
| COL4A1 | 3805 | 3236 |
| SSC5D | 4794 | 2492 |
| HYOU1 | 2212 | 4376 |
| SPARC | 3820 | 1957 |
| SCARB1 | 2518 | 2858 |
| COL1A2 | 4681 | 1250 |
| COL1A1 | 4847 | 676 |
| SCARA5 | 4409 | 415 |
| HSPH1 | 303 | 4044 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| APOE | 3947 | -1411 | -88.0 | 4717.0 |
| APOL1 | 5079 | 1818 | -2495.5 | -690.5 |
| CALR | 3782 | 1517 | 4947.0 | 4356.0 |
| CD36 | -653 | -579 | -3797.0 | 1232.0 |
| COL1A1 | 4847 | -1617 | 7.0 | 676.0 |
| COL1A2 | 4681 | -1689 | -375.0 | 1250.0 |
| COL3A1 | 4565 | 2950 | 2503.0 | 3575.0 |
| COL4A1 | 3805 | -4695 | 688.0 | 3236.0 |
| COL4A2 | 3851 | -4973 | 861.0 | 3295.0 |
| COLEC12 | 4753 | 4226 | 45.0 | 3221.0 |
| FTH1 | -3005 | -1864 | -126.0 | 409.0 |
| HSP90AA1 | -961 | 3627 | 5204.0 | 4248.0 |
| HSP90B1 | 3464 | 456 | 4896.0 | 4544.0 |
| HSPH1 | 303 | 4110 | 5024.0 | 4044.0 |
| HYOU1 | 2212 | -1426 | 4981.0 | 4376.0 |
| LRP1 | 4481 | -3605 | 1744.0 | 3531.0 |
| MASP1 | -5427 | -4170 | -1574.0 | -2446.0 |
| MSR1 | 5020 | -3413 | 5009.0 | 4999.0 |
| SCARA5 | 4409 | -2526 | -3487.0 | 415.0 |
| SCARB1 | 2518 | -4393 | -1712.0 | 2858.0 |
| SPARC | 3820 | -2638 | -565.0 | 1957.0 |
| SSC5D | 4794 | -1669 | 13.0 | 2492.0 |
| STAB2 | 2605 | -3211 | -3761.0 | -4791.0 |
tRNA processing in the mitochondrion
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0128 |
| p.adjustMANOVA | 0.0288 |
| s.dist | 0.736 |
| s.FSHD | -0.616 |
| s.hu_model | 0.0214 |
| s.Watt_m | -0.259 |
| s.Jones_m | -0.307 |
| p.FSHD | 4e-04 |
| p.hu_model | 0.902 |
| p.Watt_m | 0.137 |
| p.Jones_m | 0.078 |
| Gene | FSHD | Jones_m |
|---|---|---|
| MT-CO1 | -4597 | -3652 |
| TRMT10C | -4316 | -3659 |
| MT-ND5 | -5424 | -2299 |
| MT-CYB | -4704 | -2471 |
| MT-ND2 | -4198 | -2726 |
| MT-ND1 | -3295 | -3418 |
| MT-ND4 | -4132 | -2517 |
| MT-ND6 | -4175 | -2336 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ELAC2 | -1785 | 1503 | 1552 | 116 |
| HSD17B10 | -201 | -1178 | -480 | 3967 |
| MT-CO1 | -4597 | -3125 | -4070 | -3652 |
| MT-CYB | -4704 | -1339 | -2332 | -2471 |
| MT-ND1 | -3295 | -352 | -2191 | -3418 |
| MT-ND2 | -4198 | -1107 | -2067 | -2726 |
| MT-ND4 | -4132 | -2057 | -1579 | -2517 |
| MT-ND5 | -5424 | -3201 | -2302 | -2299 |
| MT-ND6 | -4175 | 806 | -4540 | -2336 |
| TRMT10C | -4316 | 4737 | -8 | -3659 |
| TRNT1 | -861 | 3291 | 2491 | 831 |
Defects in vitamin and cofactor metabolism
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.00155 |
| p.adjustMANOVA | 0.00492 |
| s.dist | 0.735 |
| s.FSHD | -0.346 |
| s.hu_model | 0.105 |
| s.Watt_m | -0.523 |
| s.Jones_m | -0.368 |
| p.FSHD | 0.0135 |
| p.hu_model | 0.452 |
| p.Watt_m | 0.000189 |
| p.Jones_m | 0.00864 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| MMAB | -5284 | -5244 |
| PCCA | -5148 | -4743 |
| MCCC2 | -4913 | -4935 |
| PCCB | -4099 | -5276 |
| MCCC1 | -4638 | -4559 |
| PC | -3656 | -4683 |
| MMACHC | -3319 | -3475 |
| LMBRD1 | -1893 | -1908 |
| MMAA | -4281 | -833 |
| MMADHC | -1031 | -3128 |
| CD320 | -720 | -2647 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABCD4 | 1546 | 472 | -3534 | 2703 |
| BTD | 2964 | 2543 | 2171 | -688 |
| CD320 | 2152 | -2400 | -720 | -2647 |
| HLCS | -4775 | -754 | -3859 | 1637 |
| LMBRD1 | -2102 | 307 | -1893 | -1908 |
| MCCC1 | -4819 | 3980 | -4638 | -4559 |
| MCCC2 | -4989 | 2184 | -4913 | -4935 |
| MMAA | -1319 | 2774 | -4281 | -833 |
| MMAB | -3438 | -5316 | -5284 | -5244 |
| MMACHC | -3367 | 1913 | -3319 | -3475 |
| MMADHC | -2916 | 3215 | -1031 | -3128 |
| MTR | -4381 | 2915 | -4450 | 5095 |
| MTRR | -4955 | 2157 | 3226 | -5080 |
| PC | 929 | -5164 | -3656 | -4683 |
| PCCA | -4767 | -2564 | -5148 | -4743 |
| PCCB | -3972 | -164 | -4099 | -5276 |
| TCN2 | 4160 | -1706 | -2150 | 4250 |
Degradation of the extracellular matrix
| metric | value |
|---|---|
| setSize | 58 |
| pMANOVA | 8.33e-14 |
| p.adjustMANOVA | 2.38e-12 |
| s.dist | 0.734 |
| s.FSHD | 0.54 |
| s.hu_model | -0.301 |
| s.Watt_m | 0.141 |
| s.Jones_m | 0.37 |
| p.FSHD | 1.11e-12 |
| p.hu_model | 7.64e-05 |
| p.Watt_m | 0.0628 |
| p.Jones_m | 1.15e-06 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SPP1 | 4998 | 5215 |
| CD44 | 4845 | 5080 |
| TIMP1 | 4933 | 4988 |
| MMP19 | 4747 | 5126 |
| COL14A1 | 4785 | 4769 |
| LAMC2 | 4587 | 4436 |
| CTSK | 4644 | 4241 |
| CTSS | 3773 | 5148 |
| CAPN2 | 3440 | 5001 |
| LAMC1 | 4113 | 4089 |
| MMP17 | 2906 | 5161 |
| CAPNS1 | 2784 | 5062 |
| BMP1 | 3427 | 4072 |
| ADAM15 | 3824 | 3617 |
| COL18A1 | 4351 | 3090 |
| CTSB | 2843 | 4639 |
| ADAM8 | 2510 | 5134 |
| MMP14 | 4687 | 2675 |
| ADAMTS1 | 4378 | 2787 |
| NID1 | 3391 | 3576 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADAM10 | 2507 | -1489 | -1018 | 3455 |
| ADAM15 | 3824 | -3547 | 4576 | 3617 |
| ADAM17 | 411 | 2385 | 2056 | 2726 |
| ADAM8 | 2510 | -2559 | 5057 | 5134 |
| ADAM9 | 261 | 342 | 148 | 3770 |
| ADAMTS1 | 4378 | -4528 | 4660 | 2787 |
| ADAMTS4 | 4986 | -3118 | 4239 | 2378 |
| ADAMTS5 | 3999 | 3508 | -591 | 939 |
| ADAMTS9 | 2574 | -777 | -1141 | 3604 |
| BMP1 | 3427 | -4914 | 43 | 4072 |
| BSG | -1369 | -2217 | -2093 | -5147 |
| CAPN1 | 338 | -5104 | -4377 | -1115 |
| CAPN10 | 3254 | -2153 | -2849 | 237 |
| CAPN15 | 1471 | -4608 | 1808 | 695 |
| CAPN2 | 3440 | -3365 | 4883 | 5001 |
| CAPN3 | -3909 | -4761 | -2650 | -4046 |
| CAPN5 | 3967 | -2597 | -276 | 764 |
| CAPN6 | 1229 | -4866 | 3231 | 4668 |
| CAPN7 | -4421 | -522 | -4909 | -4965 |
| CAPNS1 | 2784 | -1330 | 1730 | 5062 |
| CASP3 | 1918 | 419 | 4968 | 4110 |
| CAST | -2581 | -749 | 4823 | -93 |
| CD44 | 4845 | 826 | 4939 | 5080 |
| COL12A1 | 5001 | 1907 | 511 | 1626 |
| COL13A1 | -180 | -2295 | -1942 | 1914 |
| COL14A1 | 4785 | 831 | 1493 | 4769 |
| COL15A1 | 2478 | -169 | 1436 | 1179 |
| COL16A1 | 3846 | -2915 | 1643 | 2475 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL23A1 | 3199 | -4585 | -845 | 2418 |
| CTSB | 2843 | -1183 | -789 | 4639 |
| CTSD | 1329 | -4757 | -3993 | 2582 |
| CTSK | 4644 | 2 | 259 | 4241 |
| CTSS | 3773 | -338 | 5035 | 5148 |
| CTSV | -84 | 2189 | 34 | 331 |
| DCN | 4452 | -1036 | -890 | -1620 |
| FURIN | 1239 | -4167 | 4073 | -1204 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| HTRA1 | 4656 | -2558 | -2428 | -3749 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMA5 | 3521 | -5520 | -2717 | -2028 |
| LAMB1 | 2539 | -455 | -385 | 3101 |
| LAMB3 | 2231 | -4929 | -4569 | 386 |
| LAMC1 | 4113 | -3181 | 2501 | 4089 |
| LAMC2 | 4587 | 1336 | 5102 | 4436 |
| MMP11 | 2889 | -3240 | -393 | 1218 |
| MMP14 | 4687 | -1668 | 1618 | 2675 |
| MMP15 | 1264 | -5090 | -5214 | -4505 |
| MMP17 | 2906 | -2335 | 5119 | 5161 |
| MMP19 | 4747 | -167 | 4806 | 5126 |
| MMP2 | 4410 | -689 | -1983 | 2240 |
| NCSTN | -1401 | -2472 | 1251 | 2905 |
| NID1 | 3391 | -1249 | 709 | 3576 |
| PHYKPL | 4956 | -4988 | -3912 | -2713 |
| PSEN1 | 2583 | 2051 | 2038 | 1484 |
| SPP1 | 4998 | 1150 | 3009 | 5215 |
| TIMP1 | 4933 | -1301 | 5188 | 4988 |
| TIMP2 | 4689 | -1860 | -732 | 1606 |
Regulation of IFNA signaling
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0277 |
| p.adjustMANOVA | 0.0551 |
| s.dist | 0.732 |
| s.FSHD | 0.419 |
| s.hu_model | -0.0378 |
| s.Watt_m | 0.345 |
| s.Jones_m | 0.489 |
| p.FSHD | 0.0119 |
| p.hu_model | 0.821 |
| p.Watt_m | 0.0385 |
| p.Jones_m | 0.00335 |
| Gene | Jones_m | FSHD |
|---|---|---|
| PTPN6 | 5055 | 3645 |
| SOCS3 | 3580 | 5006 |
| STAT2 | 3818 | 2887 |
| TYK2 | 4512 | 2357 |
| USP18 | 1934 | 3625 |
| IFNAR2 | 3705 | 1842 |
| STAT1 | 2082 | 2094 |
| PTPN1 | 4669 | 739 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| IFNAR1 | -1724 | 3617 | 1074 | 4092 |
| IFNAR2 | 1842 | -1300 | 2336 | 3705 |
| JAK1 | 1002 | -1843 | 4184 | -1810 |
| PTPN1 | 739 | 1514 | 4538 | 4669 |
| PTPN11 | -1703 | -1554 | -660 | -1108 |
| PTPN6 | 3645 | -920 | 4751 | 5055 |
| SOCS1 | 4531 | 196 | 3989 | -56 |
| SOCS3 | 5006 | -282 | 5053 | 3580 |
| STAT1 | 2094 | 233 | -1721 | 2082 |
| STAT2 | 2887 | -2568 | 275 | 3818 |
| TYK2 | 2357 | -3081 | -49 | 4512 |
| USP18 | 3625 | 43 | -2543 | 1934 |
Metabolism of steroid hormones
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00982 |
| p.adjustMANOVA | 0.0232 |
| s.dist | 0.732 |
| s.FSHD | 0.218 |
| s.hu_model | -0.117 |
| s.Watt_m | 0.387 |
| s.Jones_m | 0.569 |
| p.FSHD | 0.19 |
| p.hu_model | 0.485 |
| p.Watt_m | 0.0202 |
| p.Jones_m | 0.000642 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| AKR1B1 | 5216.0 | 4722.0 |
| TSPO | 5024.0 | 4058.0 |
| HSD17B12 | 3986.0 | 5012.0 |
| AKR1B15 | 4916.5 | 3817.5 |
| STARD3NL | 3036.0 | 4478.0 |
| SRD5A3 | 4314.0 | 2905.0 |
| FDX1 | 2577.0 | 3995.0 |
| STARD4 | 357.0 | 3522.0 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AKR1B1 | -2349 | -3237 | 4722.0 | 5216.0 |
| AKR1B15 | -564 | -4434 | 3817.5 | 4916.5 |
| FDX1 | -4748 | 2316 | 3995.0 | 2577.0 |
| FDXR | 4489 | -4083 | -3246.0 | 2748.0 |
| HSD11B1 | 2224 | -1937 | -3005.0 | 1249.0 |
| HSD17B11 | 3281 | 1287 | -621.0 | 3260.0 |
| HSD17B12 | -799 | 2099 | 5012.0 | 3986.0 |
| SRD5A3 | 3626 | 3434 | 2905.0 | 4314.0 |
| STARD3 | 2626 | -137 | -1739.0 | -1167.0 |
| STARD3NL | -319 | -860 | 4478.0 | 3036.0 |
| STARD4 | 1850 | -287 | 3522.0 | 357.0 |
| TSPO | 2295 | -5082 | 4058.0 | 5024.0 |
Interleukin-4 and Interleukin-13 signaling
| metric | value |
|---|---|
| setSize | 64 |
| pMANOVA | 4.2e-12 |
| p.adjustMANOVA | 9.07e-11 |
| s.dist | 0.731 |
| s.FSHD | 0.428 |
| s.hu_model | -0.13 |
| s.Watt_m | 0.401 |
| s.Jones_m | 0.416 |
| p.FSHD | 3.24e-09 |
| p.hu_model | 0.0728 |
| p.Watt_m | 2.88e-08 |
| p.Jones_m | 8.56e-09 |
| Gene | FSHD | Jones_m |
|---|---|---|
| F13A1 | 4992 | 5143 |
| ITGB2 | 4906 | 5102 |
| TIMP1 | 4933 | 4988 |
| IL4R | 4964 | 4939 |
| VIM | 4833 | 5069 |
| ANXA1 | 4781 | 4954 |
| ITGAM | 4572 | 5107 |
| HMOX1 | 4609 | 5052 |
| VCAM1 | 4924 | 4588 |
| TNFRSF1B | 4174 | 5115 |
| ICAM1 | 4641 | 4600 |
| CDKN1A | 5043 | 4230 |
| FN1 | 4783 | 4002 |
| CCL2 | 4787 | 3964 |
| IL2RG | 4862 | 3754 |
| SOCS3 | 5006 | 3580 |
| TGFB1 | 4177 | 4099 |
| CCND1 | 3783 | 4327 |
| HSP90B1 | 3464 | 4544 |
| JUNB | 4433 | 3511 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AKT1 | -463 | -4893 | 336 | 4183 |
| ANXA1 | 4781 | 530 | 4497 | 4954 |
| BCL2 | -3161 | -4574 | -1100 | 2806 |
| BCL2L1 | 4359 | -5119 | 3393 | 1941 |
| BCL6 | -884 | -4956 | -4761 | -1050 |
| CCL2 | 4787 | 2597 | 5061 | 3964 |
| CCND1 | 3783 | 747 | 522 | 4327 |
| CD36 | -653 | -579 | -3797 | 1232 |
| CDKN1A | 5043 | -4867 | 5043 | 4230 |
| COL1A2 | 4681 | -1689 | -375 | 1250 |
| F13A1 | 4992 | -2030 | 3600 | 5143 |
| FGF2 | 1476 | 741 | -1087 | -3508 |
| FN1 | 4783 | 33 | 3978 | 4002 |
| FOS | 4091 | 1847 | 5216 | 3111 |
| FOXO1 | -5116 | -430 | 1290 | 69 |
| FOXO3 | -5444 | -42 | -1123 | 140 |
| FSCN1 | 3079 | 1688 | -926 | 3701 |
| HIF1A | 3477 | -1004 | 4959 | 2917 |
| HMOX1 | 4609 | -2806 | 5022 | 5052 |
| HSP90AA1 | -961 | 3627 | 5204 | 4248 |
| HSP90B1 | 3464 | 456 | 4896 | 4544 |
| HSPA8 | -3074 | 3645 | 5039 | 1622 |
| ICAM1 | 4641 | 1044 | 4128 | 4600 |
| IL13RA1 | 1037 | -1823 | 4469 | 4910 |
| IL2RG | 4862 | -1917 | 3687 | 3754 |
| IL4R | 4964 | -3290 | 4887 | 4939 |
| IL6R | 1481 | -5451 | 3229 | 3550 |
| IRF4 | 4366 | -1152 | 2559 | 3509 |
| ITGAM | 4572 | -2599 | 4997 | 5107 |
| ITGAX | 1897 | -886 | 3808 | 5125 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB2 | 4906 | -107 | 4945 | 5102 |
| JAK1 | 1002 | -1843 | 4184 | -1810 |
| JAK2 | -732 | -2536 | -5002 | -4773 |
| JUNB | 4433 | -2560 | 5170 | 3511 |
| LAMA5 | 3521 | -5520 | -2717 | -2028 |
| MAOA | 235 | -96 | 3883 | -4296 |
| MCL1 | -1416 | 2813 | 4778 | 185 |
| MMP2 | 4410 | -689 | -1983 | 2240 |
| MYC | 4902 | 3961 | 4838 | 1869 |
| NDN | 3836 | 1134 | 1857 | 3469 |
| PIK3R1 | -5317 | 2872 | -3114 | 468 |
| PIM1 | 4265 | -227 | 4249 | -1858 |
| POU2F1 | 1218 | 2993 | -3297 | -1284 |
| RHOU | -4158 | -4175 | -323 | -3781 |
| RORA | -3256 | -4994 | -2672 | -2510 |
| RORC | -2179 | -5186 | -4271 | 1876 |
| S1PR1 | 3355 | 2666 | 1535 | 53 |
| SOCS1 | 4531 | 196 | 3989 | -56 |
| SOCS3 | 5006 | -282 | 5053 | 3580 |
| SOCS5 | -2651 | 4112 | 1866 | 3851 |
| STAT1 | 2094 | 233 | -1721 | 2082 |
| STAT3 | 850 | -3836 | 5013 | 4348 |
| STAT6 | 4720 | -5255 | -1252 | 3190 |
| TGFB1 | 4177 | -3070 | 4895 | 4099 |
| TIMP1 | 4933 | -1301 | 5188 | 4988 |
| TNFRSF1B | 4174 | -866 | 4548 | 5115 |
| TP53 | 4943 | 566 | 3708 | 2810 |
| TWIST1 | 4751 | 2601 | 2929 | 89 |
| TYK2 | 2357 | -3081 | -49 | 4512 |
| VCAM1 | 4924 | 2842 | 4665 | 4588 |
| VEGFA | -901 | -4512 | -5139 | -3096 |
| VIM | 4833 | -2988 | 4724 | 5069 |
| ZEB1 | -2231 | -4169 | -194 | -3440 |
ECM proteoglycans
| metric | value |
|---|---|
| setSize | 37 |
| pMANOVA | 9.76e-09 |
| p.adjustMANOVA | 1.12e-07 |
| s.dist | 0.73 |
| s.FSHD | 0.569 |
| s.hu_model | -0.27 |
| s.Watt_m | 0.143 |
| s.Jones_m | 0.341 |
| p.FSHD | 2.08e-09 |
| p.hu_model | 0.00458 |
| p.Watt_m | 0.133 |
| p.Jones_m | 0.00034 |
| Gene | FSHD | Jones_m |
|---|---|---|
| BGN | 4348 | 5088 |
| VCAN | 4971 | 4285 |
| LUM | 4580 | 4537 |
| ASPN | 4403 | 3985 |
| TNC | 5019 | 3460 |
| TGFB1 | 4177 | 4099 |
| LAMC1 | 4113 | 4089 |
| ITGA9 | 4154 | 3909 |
| SERPINE1 | 4636 | 3333 |
| TNXB | 4386 | 3472 |
| NCAM1 | 3566 | 3898 |
| ITGB3 | 3693 | 2921 |
| LAMA4 | 4388 | 2343 |
| ITGAX | 1897 | 5125 |
| MUSK | 2918 | 3328 |
| LAMB1 | 2539 | 3101 |
| SPARC | 3820 | 1957 |
| LAMA2 | 3038 | 2040 |
| HSPG2 | 2035 | 2942 |
| PTPRS | 1732 | 2695 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| ASPN | 4403 | 4376 | 2320 | 3985 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| COMP | 5024 | 275 | -1007 | -884 |
| DAG1 | -4941 | -5174 | 2661 | 4271 |
| DCN | 4452 | -1036 | -890 | -1620 |
| FMOD | 4377 | -328 | -1283 | -1405 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| ITGA7 | 580 | -4661 | 2121 | -4020 |
| ITGA8 | 1156 | 4577 | 93 | 2702 |
| ITGA9 | 4154 | -5185 | 3041 | 3909 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGAX | 1897 | -886 | 3808 | 5125 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB3 | 3693 | -485 | 4867 | 2921 |
| ITGB5 | 3604 | -2545 | -4743 | -4839 |
| ITGB6 | -3832 | 471 | -3693 | 4890 |
| LAMA2 | 3038 | -3750 | -756 | 2040 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMA4 | 4388 | 736 | -121 | 2343 |
| LAMA5 | 3521 | -5520 | -2717 | -2028 |
| LAMB1 | 2539 | -455 | -385 | 3101 |
| LAMB2 | 3450 | -4834 | -3037 | -2486 |
| LAMC1 | 4113 | -3181 | 2501 | 4089 |
| LRP4 | -3904 | -5103 | -4823 | -2122 |
| LUM | 4580 | -1815 | 2455 | 4537 |
| MUSK | 2918 | -3675 | 4380 | 3328 |
| NCAM1 | 3566 | -3904 | 4088 | 3898 |
| PTPRS | 1732 | -4554 | -4143 | 2695 |
| SERPINE1 | 4636 | -210 | 5117 | 3333 |
| SPARC | 3820 | -2638 | -565 | 1957 |
| TGFB1 | 4177 | -3070 | 4895 | 4099 |
| TGFB2 | 3078 | 4561 | 1841 | -2330 |
| TGFB3 | 3860 | -5264 | -2015 | -4211 |
| TNC | 5019 | 793 | 4283 | 3460 |
| TNXB | 4386 | -65 | 2484 | 3472 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Collagen biosynthesis and modifying enzymes
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 3.12e-11 |
| p.adjustMANOVA | 5.48e-10 |
| s.dist | 0.729 |
| s.FSHD | 0.5 |
| s.hu_model | -0.352 |
| s.Watt_m | 0.117 |
| s.Jones_m | 0.379 |
| p.FSHD | 3.16e-09 |
| p.hu_model | 3.02e-05 |
| p.Watt_m | 0.167 |
| p.Jones_m | 7.07e-06 |
| Gene | FSHD | Jones_m |
|---|---|---|
| COL14A1 | 4785 | 4769 |
| COL8A1 | 4315 | 5058 |
| PLOD3 | 4888 | 4301 |
| PCOLCE2 | 4527 | 4379 |
| PPIB | 4256 | 4403 |
| COL5A2 | 4413 | 4122 |
| PCOLCE | 4784 | 3588 |
| ADAMTS2 | 4952 | 3395 |
| COL3A1 | 4565 | 3575 |
| COL6A3 | 4171 | 3393 |
| BMP1 | 3427 | 4072 |
| COL6A2 | 4692 | 2927 |
| COL6A1 | 4823 | 2788 |
| COL18A1 | 4351 | 3090 |
| CRTAP | 3334 | 3958 |
| COL5A1 | 4323 | 2999 |
| PLOD2 | 3184 | 4022 |
| COL4A2 | 3851 | 3295 |
| COL4A1 | 3805 | 3236 |
| SERPINH1 | 4694 | 2554 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADAMTS14 | 1835 | -4629 | 2211 | 2819 |
| ADAMTS2 | 4952 | -2722 | 53 | 3395 |
| BMP1 | 3427 | -4914 | 43 | 4072 |
| COL11A1 | 4414 | 2113 | -2198 | -116 |
| COL11A2 | -2800 | -2814 | -4013 | -1603 |
| COL12A1 | 5001 | 1907 | 511 | 1626 |
| COL13A1 | -180 | -2295 | -1942 | 1914 |
| COL14A1 | 4785 | 831 | 1493 | 4769 |
| COL15A1 | 2478 | -169 | 1436 | 1179 |
| COL16A1 | 3846 | -2915 | 1643 | 2475 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL1A1 | 4847 | -1617 | 7 | 676 |
| COL1A2 | 4681 | -1689 | -375 | 1250 |
| COL22A1 | 2071 | -4805 | -3249 | -3090 |
| COL23A1 | 3199 | -4585 | -845 | 2418 |
| COL24A1 | -3035 | -5069 | -4749 | 5120 |
| COL27A1 | 1066 | -5022 | 3972 | 2845 |
| COL28A1 | -3227 | 2507 | -192 | 4214 |
| COL3A1 | 4565 | 2950 | 2503 | 3575 |
| COL4A1 | 3805 | -4695 | 688 | 3236 |
| COL4A2 | 3851 | -4973 | 861 | 3295 |
| COL4A3 | -2253 | -3782 | -4833 | -1934 |
| COL4A4 | -2804 | -2983 | -3940 | -28 |
| COL4A5 | -4216 | -4266 | -3428 | -289 |
| COL5A1 | 4323 | -1537 | 2338 | 2999 |
| COL5A2 | 4413 | -2991 | 3064 | 4122 |
| COL5A3 | 3094 | -1534 | 3807 | 1554 |
| COL6A1 | 4823 | -1919 | 2015 | 2788 |
| COL6A2 | 4692 | -1812 | 2344 | 2927 |
| COL6A3 | 4171 | -119 | 2648 | 3393 |
| COL6A6 | 1139 | -2109 | -3933 | 45 |
| COL7A1 | -425 | -3189 | -3985 | -2664 |
| COL8A1 | 4315 | 881 | 4752 | 5058 |
| COL8A2 | 4912 | -457 | -2292 | -563 |
| COLGALT1 | 4647 | -3703 | -1269 | 2044 |
| COLGALT2 | -1497 | -4412 | -1435 | -792 |
| CRTAP | 3334 | -3815 | 1832 | 3958 |
| P4HA1 | -1548 | -2913 | 4840 | -4372 |
| P4HA2 | 2577 | -3906 | 2007 | -2091 |
| P4HB | -184 | -2493 | 4004 | 3152 |
| PCOLCE | 4784 | -618 | 2120 | 3588 |
| PCOLCE2 | 4527 | 1723 | -52 | 4379 |
| PLOD1 | 860 | -4628 | 381 | 2050 |
| PLOD2 | 3184 | 3503 | 4833 | 4022 |
| PLOD3 | 4888 | -4263 | 3018 | 4301 |
| PPIB | 4256 | -428 | 3462 | 4403 |
| SERPINH1 | 4694 | -3479 | 3725 | 2554 |
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0116 |
| p.adjustMANOVA | 0.0266 |
| s.dist | 0.726 |
| s.FSHD | 0.274 |
| s.hu_model | -0.193 |
| s.Watt_m | 0.503 |
| s.Jones_m | 0.403 |
| p.FSHD | 0.1 |
| p.hu_model | 0.247 |
| p.Watt_m | 0.00257 |
| p.Jones_m | 0.0158 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| CCNE1 | 4705 | 4959 |
| E2F8 | 5076 | 4501 |
| E2F1 | 4616 | 4809 |
| CCNA2 | 4247 | 5048 |
| CDKN1A | 5043 | 4230 |
| ZNF385A | 3961 | 4690 |
| CDK2 | 2660 | 4566 |
| TP53 | 3708 | 2810 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ARID3A | 4083 | -4363 | 1298 | -318 |
| CCNA2 | 2177 | 3035 | 4247 | 5048 |
| CCNE1 | 2834 | 4352 | 4705 | 4959 |
| CCNE2 | 1263 | 4626 | 145 | -2482 |
| CDK2 | 2466 | 838 | 2660 | 4566 |
| CDKN1A | 5043 | -4867 | 5043 | 4230 |
| CDKN1B | -3557 | -3241 | -2427 | -5070 |
| E2F1 | 2820 | -526 | 4616 | 4809 |
| E2F8 | 319 | -5556 | 5076 | 4501 |
| PCBP4 | -3178 | -5459 | -1853 | -2745 |
| TP53 | 4943 | 566 | 3708 | 2810 |
| ZNF385A | -4082 | -5149 | 3961 | 4690 |
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0613 |
| p.adjustMANOVA | 0.106 |
| s.dist | 0.725 |
| s.FSHD | -0.386 |
| s.hu_model | -0.141 |
| s.Watt_m | -0.468 |
| s.Jones_m | -0.371 |
| p.FSHD | 0.0344 |
| p.hu_model | 0.442 |
| p.Watt_m | 0.0105 |
| p.Jones_m | 0.042 |
| Gene | Watt_m | FSHD |
|---|---|---|
| CYP27A1 | -5277 | -5269 |
| SCP2 | -4882 | -5322 |
| RXRA | -4147 | -4228 |
| AMACR | -4008 | -3399 |
| HSD17B4 | -3004 | -4299 |
| NCOA2 | -4995 | -2521 |
| NCOA1 | -1158 | -2128 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACOT8 | -2551 | -946 | 417 | 820 |
| AMACR | -3399 | 4127 | -4008 | 40 |
| CYP27A1 | -5269 | -4450 | -5277 | -5087 |
| HSD17B4 | -4299 | 680 | -3004 | -3754 |
| HSD3B7 | 4131 | -4317 | 1041 | 2290 |
| NCOA1 | -2128 | 2605 | -1158 | -3029 |
| NCOA2 | -2521 | 143 | -4995 | -4281 |
| PTGIS | 3434 | -1895 | 927 | 1214 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
| SCP2 | -5322 | -854 | -4882 | -3079 |
Laminin interactions
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 1.99e-05 |
| p.adjustMANOVA | 0.000107 |
| s.dist | 0.724 |
| s.FSHD | 0.575 |
| s.hu_model | -0.344 |
| s.Watt_m | -0.0603 |
| s.Jones_m | 0.268 |
| p.FSHD | 1.44e-05 |
| p.hu_model | 0.00938 |
| p.Watt_m | 0.649 |
| p.Jones_m | 0.0434 |
| Gene | FSHD | hu_model |
|---|---|---|
| ITGA3 | 4809 | -5450 |
| LAMA5 | 3521 | -5520 |
| LAMB2 | 3450 | -4834 |
| LAMC1 | 4113 | -3181 |
| COL18A1 | 4351 | -2864 |
| LAMA2 | 3038 | -3750 |
| LAMB3 | 2231 | -4929 |
| HSPG2 | 2035 | -5289 |
| NID1 | 3391 | -1249 |
| LAMA3 | 3451 | -999 |
| ITGA7 | 580 | -4661 |
| ITGA6 | 1799 | -990 |
| LAMB1 | 2539 | -455 |
| ITGAV | 801 | -812 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| ITGA1 | 1435 | 1740 | -4092 | -3028 |
| ITGA3 | 4809 | -5450 | 2976 | 557 |
| ITGA6 | 1799 | -990 | -5243 | -114 |
| ITGA7 | 580 | -4661 | 2121 | -4020 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| LAMA2 | 3038 | -3750 | -756 | 2040 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMA4 | 4388 | 736 | -121 | 2343 |
| LAMA5 | 3521 | -5520 | -2717 | -2028 |
| LAMB1 | 2539 | -455 | -385 | 3101 |
| LAMB2 | 3450 | -4834 | -3037 | -2486 |
| LAMB3 | 2231 | -4929 | -4569 | 386 |
| LAMC1 | 4113 | -3181 | 2501 | 4089 |
| LAMC2 | 4587 | 1336 | 5102 | 4436 |
| NID1 | 3391 | -1249 | 709 | 3576 |
| NID2 | 2587 | 177 | -1976 | 3644 |
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0114 |
| p.adjustMANOVA | 0.0264 |
| s.dist | 0.723 |
| s.FSHD | 0.537 |
| s.hu_model | -0.36 |
| s.Watt_m | 0.162 |
| s.Jones_m | 0.28 |
| p.FSHD | 0.00204 |
| p.hu_model | 0.0389 |
| p.Watt_m | 0.352 |
| p.Jones_m | 0.108 |
| Gene | FSHD | hu_model |
|---|---|---|
| AGRN | 3889 | -4843 |
| SDC3 | 3721 | -4560 |
| GPC6 | 4618 | -2353 |
| HSPG2 | 2035 | -5289 |
| SDC1 | 3944 | -2017 |
| SDC4 | 1095 | -2361 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| EXT1 | 4706 | 3854 | 4979 | 3717 |
| EXT2 | 2935 | 2055 | 910 | -1968 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
Defective EXT2 causes exostoses 2
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0114 |
| p.adjustMANOVA | 0.0264 |
| s.dist | 0.723 |
| s.FSHD | 0.537 |
| s.hu_model | -0.36 |
| s.Watt_m | 0.162 |
| s.Jones_m | 0.28 |
| p.FSHD | 0.00204 |
| p.hu_model | 0.0389 |
| p.Watt_m | 0.352 |
| p.Jones_m | 0.108 |
| Gene | FSHD | hu_model |
|---|---|---|
| AGRN | 3889 | -4843 |
| SDC3 | 3721 | -4560 |
| GPC6 | 4618 | -2353 |
| HSPG2 | 2035 | -5289 |
| SDC1 | 3944 | -2017 |
| SDC4 | 1095 | -2361 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| EXT1 | 4706 | 3854 | 4979 | 3717 |
| EXT2 | 2935 | 2055 | 910 | -1968 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
rRNA modification in the nucleus and cytosol
| metric | value |
|---|---|
| setSize | 52 |
| pMANOVA | 1.28e-15 |
| p.adjustMANOVA | 4.91e-14 |
| s.dist | 0.722 |
| s.FSHD | -0.181 |
| s.hu_model | 0.601 |
| s.Watt_m | 0.357 |
| s.Jones_m | 0.011 |
| p.FSHD | 0.0244 |
| p.hu_model | 6.53e-14 |
| p.Watt_m | 8.81e-06 |
| p.Jones_m | 0.891 |
| Gene | hu_model | Watt_m |
|---|---|---|
| UTP14A | 4734 | 4989.5 |
| NOP58 | 4847 | 4297.0 |
| DCAF13 | 4757 | 4119.0 |
| GAR1 | 4099 | 4715.0 |
| HEATR1 | 4867 | 3812.0 |
| WDR3 | 4794 | 3504.0 |
| WDR43 | 4839 | 3438.0 |
| NOP2 | 3445 | 4776.0 |
| WDR36 | 4503 | 3463.0 |
| UTP3 | 4873 | 2896.0 |
| UTP18 | 3820 | 3693.0 |
| IMP4 | 2781 | 4269.0 |
| NOP56 | 3072 | 3816.0 |
| UTP15 | 4104 | 2746.0 |
| MPHOSPH10 | 3895 | 2797.0 |
| NOL6 | 3788 | 2734.0 |
| FBL | 4199 | 2189.0 |
| WDR75 | 3713 | 2350.0 |
| WDR46 | 3308 | 2620.0 |
| DDX49 | 2158 | 3982.0 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| BMS1 | -3925 | 3484 | -4173.0 | 2837.0 |
| DCAF13 | 2329 | 4757 | 4119.0 | 2732.0 |
| DDX47 | -2373 | 3705 | 1420.0 | -2733.0 |
| DDX49 | -365 | 2158 | 3982.0 | 971.0 |
| DHX37 | -764 | 2086 | 2942.0 | 1278.0 |
| DIEXF | 1711 | 4833 | 1136.0 | -1945.0 |
| DIMT1 | 892 | 2514 | 1435.0 | -1291.0 |
| DKC1 | -2792 | 3601 | -170.0 | -5125.0 |
| FBL | 2415 | 4199 | 2189.0 | 2712.0 |
| FCF1 | -221 | 3276 | 2030.0 | 2653.0 |
| GAR1 | 1686 | 4099 | 4715.0 | 1513.0 |
| HEATR1 | 1655 | 4867 | 3812.0 | 2362.0 |
| IMP3 | -1650 | 4497 | -955.0 | -1140.0 |
| IMP4 | -1870 | 2781 | 4269.0 | 2864.0 |
| KRR1 | -5216 | 3888 | 1101.0 | -3181.0 |
| MPHOSPH10 | -5196 | 3895 | 2797.0 | 246.0 |
| NAT10 | -2447 | 3614 | -1149.0 | 3217.0 |
| NHP2 | 919 | 685 | 2650.0 | 2538.0 |
| NOC4L | 683 | 1746 | 1992.0 | 588.0 |
| NOL11 | -4496 | 4872 | -390.0 | -2059.0 |
| NOL6 | -1455 | 3788 | 2734.0 | 3169.0 |
| NOP10 | -89 | 1321 | 902.0 | -4543.0 |
| NOP14 | -4062 | 1573 | 4346.0 | 95.0 |
| NOP2 | 304 | 3445 | 4776.0 | -617.0 |
| NOP56 | 1503 | 3072 | 3816.0 | -3435.0 |
| NOP58 | 23 | 4847 | 4297.0 | 1374.0 |
| PDCD11 | -714 | -1447 | 807.0 | 586.0 |
| PNO1 | -1122 | 4582 | 326.0 | -4540.0 |
| PWP2 | -2511 | 2440 | 737.0 | -4460.0 |
| RCL1 | -4680 | 3230 | -47.0 | -3988.0 |
| RPS14 | -996 | -1395 | 1309.0 | -278.0 |
| RPS6 | -549 | -244 | 3507.0 | -947.0 |
| RPS9 | 1112 | -1094 | 1563.0 | 1857.0 |
| RRP36 | -3795 | 1515 | 1834.0 | 1655.0 |
| RRP7A | 133 | 2118 | 3584.0 | 2547.0 |
| RRP9 | -593 | 761 | 2301.0 | -3087.0 |
| TBL3 | -369 | -1531 | 1052.0 | -1653.0 |
| THUMPD1 | -5026 | 4625 | -2539.0 | -2560.0 |
| TSR3 | -967 | -3564 | -3243.0 | -3970.0 |
| UTP14A | -1437 | 4734 | 4989.5 | 4165.5 |
| UTP14C | -5428 | 1548 | 4989.5 | 4165.5 |
| UTP15 | -1506 | 4104 | 2746.0 | -667.0 |
| UTP18 | -4246 | 3820 | 3693.0 | 4299.0 |
| UTP20 | -3726 | 4140 | 236.0 | 3401.0 |
| UTP3 | 2107 | 4873 | 2896.0 | 1100.0 |
| UTP6 | 1200 | 4736 | -4463.0 | -4013.0 |
| WBSCR22 | -478 | 1724 | -1524.0 | -2587.0 |
| WDR3 | -1677 | 4794 | 3504.0 | 1578.0 |
| WDR36 | -2967 | 4503 | 3463.0 | 5191.0 |
| WDR43 | -2876 | 4839 | 3438.0 | -2273.0 |
| WDR46 | 3761 | 3308 | 2620.0 | 1772.0 |
| WDR75 | 1462 | 3713 | 2350.0 | -1228.0 |
RHO GTPases Activate WASPs and WAVEs
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 2.9e-05 |
| p.adjustMANOVA | 0.000149 |
| s.dist | 0.718 |
| s.FSHD | 0.362 |
| s.hu_model | 0.0906 |
| s.Watt_m | 0.428 |
| s.Jones_m | 0.44 |
| p.FSHD | 0.000485 |
| p.hu_model | 0.383 |
| p.Watt_m | 3.82e-05 |
| p.Jones_m | 2.24e-05 |
| Gene | Jones_m | Watt_m |
|---|---|---|
| ABI2 | 5112 | 5000 |
| ACTR3 | 4879 | 5086 |
| ARPC5 | 4898 | 4796 |
| ARPC1B | 4719 | 4808 |
| ACTB | 4471 | 4929 |
| BAIAP2 | 4353 | 4993 |
| ARPC2 | 4615 | 4570 |
| ACTR2 | 4894 | 3889 |
| ARPC3 | 4579 | 3719 |
| ACTG1 | 3342 | 4938 |
| BRK1 | 4085 | 3060 |
| ARPC4 | 4316 | 2543 |
| NCKAP1 | 2872 | 3543 |
| ABI1 | 3901 | 2528 |
| WIPF1 | 3677 | 1663 |
| WASF2 | 3899 | 1495 |
| ARPC1A | 2218 | 2622 |
| MAPK3 | 1133 | 3682 |
| NCK1 | 3133 | 1276 |
| WASL | 1120 | 3230 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABI1 | 2432 | 3761 | 2528 | 3901 |
| ABI2 | 2698 | -307 | 5000 | 5112 |
| ABL1 | 2719 | -4474 | -3505 | -1534 |
| ACTB | 4268 | 929 | 4929 | 4471 |
| ACTG1 | 4406 | -3035 | 4938 | 3342 |
| ACTR2 | 290 | 3520 | 3889 | 4894 |
| ACTR3 | 2481 | 1361 | 5086 | 4879 |
| ARPC1A | 2458 | -120 | 2622 | 2218 |
| ARPC1B | 4929 | 660 | 4808 | 4719 |
| ARPC2 | 493 | 1342 | 4570 | 4615 |
| ARPC3 | 2801 | 2849 | 3719 | 4579 |
| ARPC4 | 4280 | 1681 | 2543 | 4316 |
| ARPC5 | 4326 | 2275 | 4796 | 4898 |
| BAIAP2 | 3612 | -638 | 4993 | 4353 |
| BRK1 | -453 | 2008 | 3060 | 4085 |
| CDC42 | 1017 | 3281 | 746 | 2621 |
| CYFIP2 | 2025 | -3726 | -1121 | 722 |
| GRB2 | 2101 | -3999 | 4449 | 3 |
| MAPK1 | 2000 | 1970 | -642 | -2044 |
| MAPK3 | 2715 | -1012 | 3682 | 1133 |
| NCK1 | -2442 | 3688 | 1276 | 3133 |
| NCKAP1 | -5051 | 3536 | 3543 | 2872 |
| NCKIPSD | 1603 | -2784 | 696 | -791 |
| PTK2 | 692 | -2465 | -1494 | -4001 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| WASF2 | 3489 | -4597 | 1495 | 3899 |
| WASF3 | -651 | -1003 | 710 | -451 |
| WASL | -3955 | 2660 | 3230 | 1120 |
| WIPF1 | 4205 | -2520 | 1663 | 3677 |
| WIPF2 | 2810 | 3272 | -497 | -676 |
| WIPF3 | 1526 | -5045 | -5000 | 1136 |
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.000989 |
| p.adjustMANOVA | 0.00337 |
| s.dist | 0.717 |
| s.FSHD | 0.114 |
| s.hu_model | -0.245 |
| s.Watt_m | 0.0504 |
| s.Jones_m | 0.662 |
| p.FSHD | 0.532 |
| p.hu_model | 0.18 |
| p.Watt_m | 0.782 |
| p.Jones_m | 0.000288 |
| Gene | Jones_m | hu_model |
|---|---|---|
| IKBKB | 3732 | -4041 |
| TRIM25 | 4120 | -3200 |
| RNF135 | 2448 | -3630 |
| CASP8 | 4108 | -1624 |
| FADD | 4118 | -568 |
| MAVS | 423 | -4708 |
| IFIH1 | 4801 | -203 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CASP8 | 4576 | -1624 | 3056 | 4108 |
| CHUK | -5003 | 213 | 946 | 4752 |
| DDX58 | 909 | 1576 | -903 | 3117 |
| FADD | 588 | -568 | 4829 | 4118 |
| IFIH1 | 3035 | -203 | -3084 | 4801 |
| IKBKB | -4380 | -4041 | 570 | 3732 |
| MAVS | -4398 | -4708 | -4806 | 423 |
| RIPK1 | 2917 | 322 | 711 | 2881 |
| RNF135 | 3350 | -3630 | 979 | 2448 |
| TRIM25 | 2601 | -3200 | -118 | 4120 |
FCGR3A-mediated phagocytosis
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 5.38e-08 |
| p.adjustMANOVA | 5.42e-07 |
| s.dist | 0.713 |
| s.FSHD | 0.384 |
| s.hu_model | -0.0119 |
| s.Watt_m | 0.377 |
| s.Jones_m | 0.467 |
| p.FSHD | 5.2e-06 |
| p.hu_model | 0.888 |
| p.Watt_m | 8.09e-06 |
| p.Jones_m | 3.05e-08 |
| Gene | Jones_m | FSHD |
|---|---|---|
| ARPC1B | 4719 | 4929 |
| ELMO1 | 4983 | 4381 |
| ARPC5 | 4898 | 4326 |
| MYH9 | 4498 | 4535 |
| ACTB | 4471 | 4268 |
| ARPC4 | 4316 | 4280 |
| VAV2 | 3870 | 4713 |
| MYO9B | 4853 | 3722 |
| FYN | 4010 | 4466 |
| BAIAP2 | 4353 | 3612 |
| WIPF1 | 3677 | 4205 |
| LYN | 4433 | 3429 |
| ACTG1 | 3342 | 4406 |
| VAV3 | 5070 | 2792 |
| ABI2 | 5112 | 2698 |
| WASF2 | 3899 | 3489 |
| ARPC3 | 4579 | 2801 |
| ACTR3 | 4879 | 2481 |
| DOCK1 | 3013 | 3791 |
| SRC | 2269 | 5021 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABI1 | 2432 | 3761 | 2528 | 3901 |
| ABI2 | 2698 | -307 | 5000 | 5112 |
| ABL1 | 2719 | -4474 | -3505 | -1534 |
| ACTB | 4268 | 929 | 4929 | 4471 |
| ACTG1 | 4406 | -3035 | 4938 | 3342 |
| ACTR2 | 290 | 3520 | 3889 | 4894 |
| ACTR3 | 2481 | 1361 | 5086 | 4879 |
| ARPC1A | 2458 | -120 | 2622 | 2218 |
| ARPC1B | 4929 | 660 | 4808 | 4719 |
| ARPC2 | 493 | 1342 | 4570 | 4615 |
| ARPC3 | 2801 | 2849 | 3719 | 4579 |
| ARPC4 | 4280 | 1681 | 2543 | 4316 |
| ARPC5 | 4326 | 2275 | 4796 | 4898 |
| BAIAP2 | 3612 | -638 | 4993 | 4353 |
| BRK1 | -453 | 2008 | 3060 | 4085 |
| CDC42 | 1017 | 3281 | 746 | 2621 |
| CRK | -421 | 2125 | 2238 | -3653 |
| CYFIP2 | 2025 | -3726 | -1121 | 722 |
| DOCK1 | 3791 | -225 | -40 | 3013 |
| ELMO1 | 4381 | -2137 | 1433 | 4983 |
| ELMO2 | -2210 | -353 | 410 | -2080 |
| FYN | 4466 | -2813 | 3642 | 4010 |
| GRB2 | 2101 | -3999 | 4449 | 3 |
| LYN | 3429 | 775 | 3940 | 4433 |
| MAPK1 | 2000 | 1970 | -642 | -2044 |
| MAPK3 | 2715 | -1012 | 3682 | 1133 |
| MYH2 | -3590 | -3040 | -851 | -2213 |
| MYH9 | 4535 | -1853 | 4150 | 4498 |
| MYO10 | -1902 | 1365 | 289 | 2204 |
| MYO1C | 2172 | -4782 | 3479 | 3687 |
| MYO5A | 981 | -875 | 3241 | 5027 |
| MYO9B | 3722 | -1875 | 4011 | 4853 |
| NCK1 | -2442 | 3688 | 1276 | 3133 |
| NCKAP1 | -5051 | 3536 | 3543 | 2872 |
| NCKIPSD | 1603 | -2784 | 696 | -791 |
| PTK2 | 692 | -2465 | -1494 | -4001 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| SRC | 5021 | -3860 | 1364 | 2269 |
| VAV2 | 4713 | -4898 | -893 | 3870 |
| VAV3 | 2792 | 184 | -1056 | 5070 |
| WASF2 | 3489 | -4597 | 1495 | 3899 |
| WASF3 | -651 | -1003 | 710 | -451 |
| WASL | -3955 | 2660 | 3230 | 1120 |
| WIPF1 | 4205 | -2520 | 1663 | 3677 |
| WIPF2 | 2810 | 3272 | -497 | -676 |
| WIPF3 | 1526 | -5045 | -5000 | 1136 |
| YES1 | 1006 | -175 | -2910 | 2958 |
Leishmania phagocytosis
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 5.38e-08 |
| p.adjustMANOVA | 5.42e-07 |
| s.dist | 0.713 |
| s.FSHD | 0.384 |
| s.hu_model | -0.0119 |
| s.Watt_m | 0.377 |
| s.Jones_m | 0.467 |
| p.FSHD | 5.2e-06 |
| p.hu_model | 0.888 |
| p.Watt_m | 8.09e-06 |
| p.Jones_m | 3.05e-08 |
| Gene | Jones_m | FSHD |
|---|---|---|
| ARPC1B | 4719 | 4929 |
| ELMO1 | 4983 | 4381 |
| ARPC5 | 4898 | 4326 |
| MYH9 | 4498 | 4535 |
| ACTB | 4471 | 4268 |
| ARPC4 | 4316 | 4280 |
| VAV2 | 3870 | 4713 |
| MYO9B | 4853 | 3722 |
| FYN | 4010 | 4466 |
| BAIAP2 | 4353 | 3612 |
| WIPF1 | 3677 | 4205 |
| LYN | 4433 | 3429 |
| ACTG1 | 3342 | 4406 |
| VAV3 | 5070 | 2792 |
| ABI2 | 5112 | 2698 |
| WASF2 | 3899 | 3489 |
| ARPC3 | 4579 | 2801 |
| ACTR3 | 4879 | 2481 |
| DOCK1 | 3013 | 3791 |
| SRC | 2269 | 5021 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABI1 | 2432 | 3761 | 2528 | 3901 |
| ABI2 | 2698 | -307 | 5000 | 5112 |
| ABL1 | 2719 | -4474 | -3505 | -1534 |
| ACTB | 4268 | 929 | 4929 | 4471 |
| ACTG1 | 4406 | -3035 | 4938 | 3342 |
| ACTR2 | 290 | 3520 | 3889 | 4894 |
| ACTR3 | 2481 | 1361 | 5086 | 4879 |
| ARPC1A | 2458 | -120 | 2622 | 2218 |
| ARPC1B | 4929 | 660 | 4808 | 4719 |
| ARPC2 | 493 | 1342 | 4570 | 4615 |
| ARPC3 | 2801 | 2849 | 3719 | 4579 |
| ARPC4 | 4280 | 1681 | 2543 | 4316 |
| ARPC5 | 4326 | 2275 | 4796 | 4898 |
| BAIAP2 | 3612 | -638 | 4993 | 4353 |
| BRK1 | -453 | 2008 | 3060 | 4085 |
| CDC42 | 1017 | 3281 | 746 | 2621 |
| CRK | -421 | 2125 | 2238 | -3653 |
| CYFIP2 | 2025 | -3726 | -1121 | 722 |
| DOCK1 | 3791 | -225 | -40 | 3013 |
| ELMO1 | 4381 | -2137 | 1433 | 4983 |
| ELMO2 | -2210 | -353 | 410 | -2080 |
| FYN | 4466 | -2813 | 3642 | 4010 |
| GRB2 | 2101 | -3999 | 4449 | 3 |
| LYN | 3429 | 775 | 3940 | 4433 |
| MAPK1 | 2000 | 1970 | -642 | -2044 |
| MAPK3 | 2715 | -1012 | 3682 | 1133 |
| MYH2 | -3590 | -3040 | -851 | -2213 |
| MYH9 | 4535 | -1853 | 4150 | 4498 |
| MYO10 | -1902 | 1365 | 289 | 2204 |
| MYO1C | 2172 | -4782 | 3479 | 3687 |
| MYO5A | 981 | -875 | 3241 | 5027 |
| MYO9B | 3722 | -1875 | 4011 | 4853 |
| NCK1 | -2442 | 3688 | 1276 | 3133 |
| NCKAP1 | -5051 | 3536 | 3543 | 2872 |
| NCKIPSD | 1603 | -2784 | 696 | -791 |
| PTK2 | 692 | -2465 | -1494 | -4001 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| SRC | 5021 | -3860 | 1364 | 2269 |
| VAV2 | 4713 | -4898 | -893 | 3870 |
| VAV3 | 2792 | 184 | -1056 | 5070 |
| WASF2 | 3489 | -4597 | 1495 | 3899 |
| WASF3 | -651 | -1003 | 710 | -451 |
| WASL | -3955 | 2660 | 3230 | 1120 |
| WIPF1 | 4205 | -2520 | 1663 | 3677 |
| WIPF2 | 2810 | 3272 | -497 | -676 |
| WIPF3 | 1526 | -5045 | -5000 | 1136 |
| YES1 | 1006 | -175 | -2910 | 2958 |
Parasite infection
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 5.38e-08 |
| p.adjustMANOVA | 5.42e-07 |
| s.dist | 0.713 |
| s.FSHD | 0.384 |
| s.hu_model | -0.0119 |
| s.Watt_m | 0.377 |
| s.Jones_m | 0.467 |
| p.FSHD | 5.2e-06 |
| p.hu_model | 0.888 |
| p.Watt_m | 8.09e-06 |
| p.Jones_m | 3.05e-08 |
| Gene | Jones_m | FSHD |
|---|---|---|
| ARPC1B | 4719 | 4929 |
| ELMO1 | 4983 | 4381 |
| ARPC5 | 4898 | 4326 |
| MYH9 | 4498 | 4535 |
| ACTB | 4471 | 4268 |
| ARPC4 | 4316 | 4280 |
| VAV2 | 3870 | 4713 |
| MYO9B | 4853 | 3722 |
| FYN | 4010 | 4466 |
| BAIAP2 | 4353 | 3612 |
| WIPF1 | 3677 | 4205 |
| LYN | 4433 | 3429 |
| ACTG1 | 3342 | 4406 |
| VAV3 | 5070 | 2792 |
| ABI2 | 5112 | 2698 |
| WASF2 | 3899 | 3489 |
| ARPC3 | 4579 | 2801 |
| ACTR3 | 4879 | 2481 |
| DOCK1 | 3013 | 3791 |
| SRC | 2269 | 5021 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABI1 | 2432 | 3761 | 2528 | 3901 |
| ABI2 | 2698 | -307 | 5000 | 5112 |
| ABL1 | 2719 | -4474 | -3505 | -1534 |
| ACTB | 4268 | 929 | 4929 | 4471 |
| ACTG1 | 4406 | -3035 | 4938 | 3342 |
| ACTR2 | 290 | 3520 | 3889 | 4894 |
| ACTR3 | 2481 | 1361 | 5086 | 4879 |
| ARPC1A | 2458 | -120 | 2622 | 2218 |
| ARPC1B | 4929 | 660 | 4808 | 4719 |
| ARPC2 | 493 | 1342 | 4570 | 4615 |
| ARPC3 | 2801 | 2849 | 3719 | 4579 |
| ARPC4 | 4280 | 1681 | 2543 | 4316 |
| ARPC5 | 4326 | 2275 | 4796 | 4898 |
| BAIAP2 | 3612 | -638 | 4993 | 4353 |
| BRK1 | -453 | 2008 | 3060 | 4085 |
| CDC42 | 1017 | 3281 | 746 | 2621 |
| CRK | -421 | 2125 | 2238 | -3653 |
| CYFIP2 | 2025 | -3726 | -1121 | 722 |
| DOCK1 | 3791 | -225 | -40 | 3013 |
| ELMO1 | 4381 | -2137 | 1433 | 4983 |
| ELMO2 | -2210 | -353 | 410 | -2080 |
| FYN | 4466 | -2813 | 3642 | 4010 |
| GRB2 | 2101 | -3999 | 4449 | 3 |
| LYN | 3429 | 775 | 3940 | 4433 |
| MAPK1 | 2000 | 1970 | -642 | -2044 |
| MAPK3 | 2715 | -1012 | 3682 | 1133 |
| MYH2 | -3590 | -3040 | -851 | -2213 |
| MYH9 | 4535 | -1853 | 4150 | 4498 |
| MYO10 | -1902 | 1365 | 289 | 2204 |
| MYO1C | 2172 | -4782 | 3479 | 3687 |
| MYO5A | 981 | -875 | 3241 | 5027 |
| MYO9B | 3722 | -1875 | 4011 | 4853 |
| NCK1 | -2442 | 3688 | 1276 | 3133 |
| NCKAP1 | -5051 | 3536 | 3543 | 2872 |
| NCKIPSD | 1603 | -2784 | 696 | -791 |
| PTK2 | 692 | -2465 | -1494 | -4001 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| SRC | 5021 | -3860 | 1364 | 2269 |
| VAV2 | 4713 | -4898 | -893 | 3870 |
| VAV3 | 2792 | 184 | -1056 | 5070 |
| WASF2 | 3489 | -4597 | 1495 | 3899 |
| WASF3 | -651 | -1003 | 710 | -451 |
| WASL | -3955 | 2660 | 3230 | 1120 |
| WIPF1 | 4205 | -2520 | 1663 | 3677 |
| WIPF2 | 2810 | 3272 | -497 | -676 |
| WIPF3 | 1526 | -5045 | -5000 | 1136 |
| YES1 | 1006 | -175 | -2910 | 2958 |
Cristae formation
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0576 |
| p.adjustMANOVA | 0.102 |
| s.dist | 0.712 |
| s.FSHD | -0.512 |
| s.hu_model | 0.0502 |
| s.Watt_m | -0.293 |
| s.Jones_m | -0.395 |
| p.FSHD | 0.00503 |
| p.hu_model | 0.784 |
| p.Watt_m | 0.109 |
| p.Jones_m | 0.0304 |
| Gene | FSHD | Jones_m |
|---|---|---|
| APOOL | -5041 | -4307 |
| HSPA9 | -4467 | -4245 |
| IMMT | -4687 | -3966 |
| CHCHD3 | -4596 | -3379 |
| DNAJC11 | -4805 | -2021 |
| TMEM11 | -1792 | -3773 |
| SAMM50 | -2462 | -2001 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| APOOL | -5041 | -69 | -606 | -4307 |
| CHCHD3 | -4596 | 120 | -1967 | -3379 |
| CHCHD6 | 2185 | -2148 | -1823 | 2590 |
| DNAJC11 | -4805 | -2120 | -2786 | -2021 |
| HSPA9 | -4467 | 2321 | -1418 | -4245 |
| IMMT | -4687 | -289 | -5001 | -3966 |
| MTX1 | 781 | 2000 | 245 | -2260 |
| MTX2 | -3900 | 50 | 193 | 2197 |
| SAMM50 | -2462 | 1129 | -3622 | -2001 |
| TMEM11 | -1792 | -1318 | 877 | -3773 |
Collagen formation
| metric | value |
|---|---|
| setSize | 63 |
| pMANOVA | 7.69e-15 |
| p.adjustMANOVA | 2.62e-13 |
| s.dist | 0.711 |
| s.FSHD | 0.507 |
| s.hu_model | -0.309 |
| s.Watt_m | 0.0807 |
| s.Jones_m | 0.383 |
| p.FSHD | 3.43e-12 |
| p.hu_model | 2.29e-05 |
| p.Watt_m | 0.269 |
| p.Jones_m | 1.45e-07 |
| Gene | FSHD | Jones_m |
|---|---|---|
| COL14A1 | 4785 | 4769 |
| LOXL3 | 4563 | 4925 |
| COL8A1 | 4315 | 5058 |
| PLOD3 | 4888 | 4301 |
| LAMC2 | 4587 | 4436 |
| PCOLCE2 | 4527 | 4379 |
| CTSS | 3773 | 5148 |
| LOXL1 | 4187 | 4524 |
| PPIB | 4256 | 4403 |
| COL5A2 | 4413 | 4122 |
| CD151 | 4172 | 4305 |
| LOXL2 | 5054 | 3520 |
| LOX | 4606 | 3765 |
| PCOLCE | 4784 | 3588 |
| ADAMTS2 | 4952 | 3395 |
| COL3A1 | 4565 | 3575 |
| COL6A3 | 4171 | 3393 |
| BMP1 | 3427 | 4072 |
| COL6A2 | 4692 | 2927 |
| COL6A1 | 4823 | 2788 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADAMTS14 | 1835 | -4629 | 2211 | 2819 |
| ADAMTS2 | 4952 | -2722 | 53 | 3395 |
| BMP1 | 3427 | -4914 | 43 | 4072 |
| CD151 | 4172 | -5328 | -921 | 4305 |
| COL11A1 | 4414 | 2113 | -2198 | -116 |
| COL11A2 | -2800 | -2814 | -4013 | -1603 |
| COL12A1 | 5001 | 1907 | 511 | 1626 |
| COL13A1 | -180 | -2295 | -1942 | 1914 |
| COL14A1 | 4785 | 831 | 1493 | 4769 |
| COL15A1 | 2478 | -169 | 1436 | 1179 |
| COL16A1 | 3846 | -2915 | 1643 | 2475 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL1A1 | 4847 | -1617 | 7 | 676 |
| COL1A2 | 4681 | -1689 | -375 | 1250 |
| COL22A1 | 2071 | -4805 | -3249 | -3090 |
| COL23A1 | 3199 | -4585 | -845 | 2418 |
| COL24A1 | -3035 | -5069 | -4749 | 5120 |
| COL27A1 | 1066 | -5022 | 3972 | 2845 |
| COL28A1 | -3227 | 2507 | -192 | 4214 |
| COL3A1 | 4565 | 2950 | 2503 | 3575 |
| COL4A1 | 3805 | -4695 | 688 | 3236 |
| COL4A2 | 3851 | -4973 | 861 | 3295 |
| COL4A3 | -2253 | -3782 | -4833 | -1934 |
| COL4A4 | -2804 | -2983 | -3940 | -28 |
| COL4A5 | -4216 | -4266 | -3428 | -289 |
| COL5A1 | 4323 | -1537 | 2338 | 2999 |
| COL5A2 | 4413 | -2991 | 3064 | 4122 |
| COL5A3 | 3094 | -1534 | 3807 | 1554 |
| COL6A1 | 4823 | -1919 | 2015 | 2788 |
| COL6A2 | 4692 | -1812 | 2344 | 2927 |
| COL6A3 | 4171 | -119 | 2648 | 3393 |
| COL6A6 | 1139 | -2109 | -3933 | 45 |
| COL7A1 | -425 | -3189 | -3985 | -2664 |
| COL8A1 | 4315 | 881 | 4752 | 5058 |
| COL8A2 | 4912 | -457 | -2292 | -563 |
| COLGALT1 | 4647 | -3703 | -1269 | 2044 |
| COLGALT2 | -1497 | -4412 | -1435 | -792 |
| CRTAP | 3334 | -3815 | 1832 | 3958 |
| CTSB | 2843 | -1183 | -789 | 4639 |
| CTSS | 3773 | -338 | 5035 | 5148 |
| CTSV | -84 | 2189 | 34 | 331 |
| DST | -3834 | -1727 | -4289 | -4863 |
| ITGA6 | 1799 | -990 | -5243 | -114 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMB3 | 2231 | -4929 | -4569 | 386 |
| LAMC2 | 4587 | 1336 | 5102 | 4436 |
| LOX | 4606 | 4062 | 3160 | 3765 |
| LOXL1 | 4187 | -1569 | 3956 | 4524 |
| LOXL2 | 5054 | -3017 | 2997 | 3520 |
| LOXL3 | 4563 | -1100 | 1944 | 4925 |
| LOXL4 | 3456 | 552 | 27 | 3757 |
| P4HA1 | -1548 | -2913 | 4840 | -4372 |
| P4HA2 | 2577 | -3906 | 2007 | -2091 |
| P4HB | -184 | -2493 | 4004 | 3152 |
| PCOLCE | 4784 | -618 | 2120 | 3588 |
| PCOLCE2 | 4527 | 1723 | -52 | 4379 |
| PLEC | -3017 | -5409 | -1604 | -3459 |
| PLOD1 | 860 | -4628 | 381 | 2050 |
| PLOD2 | 3184 | 3503 | 4833 | 4022 |
| PLOD3 | 4888 | -4263 | 3018 | 4301 |
| PPIB | 4256 | -428 | 3462 | 4403 |
| PXDN | 3490 | -1421 | -3444 | 3436 |
| SERPINH1 | 4694 | -3479 | 3725 | 2554 |
Extracellular matrix organization
| metric | value |
|---|---|
| setSize | 192 |
| pMANOVA | 7.97e-44 |
| p.adjustMANOVA | 3.27e-41 |
| s.dist | 0.711 |
| s.FSHD | 0.545 |
| s.hu_model | -0.258 |
| s.Watt_m | 0.142 |
| s.Jones_m | 0.348 |
| p.FSHD | 9.51e-39 |
| p.hu_model | 8.04e-10 |
| p.Watt_m | 0.000716 |
| p.Jones_m | 1.07e-16 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SPP1 | 4998 | 5215 |
| ADAM12 | 5018 | 5038 |
| ITGB2 | 4906 | 5102 |
| ACTN1 | 4991 | 4955 |
| CD44 | 4845 | 5080 |
| TIMP1 | 4933 | 4988 |
| MMP19 | 4747 | 5126 |
| ITGAM | 4572 | 5107 |
| COL14A1 | 4785 | 4769 |
| VCAM1 | 4924 | 4588 |
| LOXL3 | 4563 | 4925 |
| SDC2 | 4456 | 5008 |
| BGN | 4348 | 5088 |
| COL8A1 | 4315 | 5058 |
| ICAM1 | 4641 | 4600 |
| VCAN | 4971 | 4285 |
| PLOD3 | 4888 | 4301 |
| MFAP5 | 4668 | 4499 |
| LUM | 4580 | 4537 |
| LAMC2 | 4587 | 4436 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACTN1 | 4991 | -673 | 3653 | 4955 |
| ADAM10 | 2507 | -1489 | -1018 | 3455 |
| ADAM12 | 5018 | 643 | 5019 | 5038 |
| ADAM15 | 3824 | -3547 | 4576 | 3617 |
| ADAM17 | 411 | 2385 | 2056 | 2726 |
| ADAM19 | -535 | -4618 | -2690 | 2501 |
| ADAM8 | 2510 | -2559 | 5057 | 5134 |
| ADAM9 | 261 | 342 | 148 | 3770 |
| ADAMTS1 | 4378 | -4528 | 4660 | 2787 |
| ADAMTS14 | 1835 | -4629 | 2211 | 2819 |
| ADAMTS2 | 4952 | -2722 | 53 | 3395 |
| ADAMTS4 | 4986 | -3118 | 4239 | 2378 |
| ADAMTS5 | 3999 | 3508 | -591 | 939 |
| ADAMTS9 | 2574 | -777 | -1141 | 3604 |
| AGRN | 3889 | -4843 | -2922 | 760 |
| ASPN | 4403 | 4376 | 2320 | 3985 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| BMP1 | 3427 | -4914 | 43 | 4072 |
| BMP2 | 3157 | -4202 | 820 | -1673 |
| BMP4 | 2116 | 329 | 908 | 307 |
| BSG | -1369 | -2217 | -2093 | -5147 |
| CAPN1 | 338 | -5104 | -4377 | -1115 |
| CAPN10 | 3254 | -2153 | -2849 | 237 |
| CAPN15 | 1471 | -4608 | 1808 | 695 |
| CAPN2 | 3440 | -3365 | 4883 | 5001 |
| CAPN3 | -3909 | -4761 | -2650 | -4046 |
| CAPN5 | 3967 | -2597 | -276 | 764 |
| CAPN6 | 1229 | -4866 | 3231 | 4668 |
| CAPN7 | -4421 | -522 | -4909 | -4965 |
| CAPNS1 | 2784 | -1330 | 1730 | 5062 |
| CASK | 1599 | 2860 | 3171 | 3957 |
| CASP3 | 1918 | 419 | 4968 | 4110 |
| CAST | -2581 | -749 | 4823 | -93 |
| CD151 | 4172 | -5328 | -921 | 4305 |
| CD44 | 4845 | 826 | 4939 | 5080 |
| CD47 | 3471 | -2154 | 2654 | 4552 |
| COL11A1 | 4414 | 2113 | -2198 | -116 |
| COL11A2 | -2800 | -2814 | -4013 | -1603 |
| COL12A1 | 5001 | 1907 | 511 | 1626 |
| COL13A1 | -180 | -2295 | -1942 | 1914 |
| COL14A1 | 4785 | 831 | 1493 | 4769 |
| COL15A1 | 2478 | -169 | 1436 | 1179 |
| COL16A1 | 3846 | -2915 | 1643 | 2475 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL1A1 | 4847 | -1617 | 7 | 676 |
| COL1A2 | 4681 | -1689 | -375 | 1250 |
| COL22A1 | 2071 | -4805 | -3249 | -3090 |
| COL23A1 | 3199 | -4585 | -845 | 2418 |
| COL24A1 | -3035 | -5069 | -4749 | 5120 |
| COL27A1 | 1066 | -5022 | 3972 | 2845 |
| COL28A1 | -3227 | 2507 | -192 | 4214 |
| COL3A1 | 4565 | 2950 | 2503 | 3575 |
| COL4A1 | 3805 | -4695 | 688 | 3236 |
| COL4A2 | 3851 | -4973 | 861 | 3295 |
| COL4A3 | -2253 | -3782 | -4833 | -1934 |
| COL4A4 | -2804 | -2983 | -3940 | -28 |
| COL4A5 | -4216 | -4266 | -3428 | -289 |
| COL5A1 | 4323 | -1537 | 2338 | 2999 |
| COL5A2 | 4413 | -2991 | 3064 | 4122 |
| COL5A3 | 3094 | -1534 | 3807 | 1554 |
| COL6A1 | 4823 | -1919 | 2015 | 2788 |
| COL6A2 | 4692 | -1812 | 2344 | 2927 |
| COL6A3 | 4171 | -119 | 2648 | 3393 |
| COL6A6 | 1139 | -2109 | -3933 | 45 |
| COL7A1 | -425 | -3189 | -3985 | -2664 |
| COL8A1 | 4315 | 881 | 4752 | 5058 |
| COL8A2 | 4912 | -457 | -2292 | -563 |
| COLGALT1 | 4647 | -3703 | -1269 | 2044 |
| COLGALT2 | -1497 | -4412 | -1435 | -792 |
| COMP | 5024 | 275 | -1007 | -884 |
| CRTAP | 3334 | -3815 | 1832 | 3958 |
| CTSB | 2843 | -1183 | -789 | 4639 |
| CTSD | 1329 | -4757 | -3993 | 2582 |
| CTSK | 4644 | 2 | 259 | 4241 |
| CTSS | 3773 | -338 | 5035 | 5148 |
| CTSV | -84 | 2189 | 34 | 331 |
| DAG1 | -4941 | -5174 | 2661 | 4271 |
| DCN | 4452 | -1036 | -890 | -1620 |
| DDR1 | -292 | -4722 | -249 | -4038 |
| DDR2 | 3328 | -1929 | 164 | 2397 |
| DMD | -4135 | -2931 | -4460 | -5048 |
| DST | -3834 | -1727 | -4289 | -4863 |
| EFEMP1 | 4878 | 1197 | 2548 | -562 |
| EFEMP2 | 1698 | -4478 | 2866 | 4207 |
| ELN | 4832 | -4996 | -384 | 1614 |
| F11R | 3414 | -2271 | -667 | -1517 |
| FBLN1 | 4502 | -1609 | 1591 | -376 |
| FBLN2 | 3856 | -641 | 3313 | 4216 |
| FBLN5 | 3811 | 1519 | -1289 | -1272 |
| FBN1 | 4504 | 636 | 3601 | 2988 |
| FGF2 | 1476 | 741 | -1087 | -3508 |
| FMOD | 4377 | -328 | -1283 | -1405 |
| FN1 | 4783 | 33 | 3978 | 4002 |
| FURIN | 1239 | -4167 | 4073 | -1204 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| HTRA1 | 4656 | -2558 | -2428 | -3749 |
| ICAM1 | 4641 | 1044 | 4128 | 4600 |
| ICAM2 | 1999 | -1485 | -3439 | -639 |
| ITGA1 | 1435 | 1740 | -4092 | -3028 |
| ITGA10 | 4023 | -1852 | -979 | -1086 |
| ITGA11 | 4615 | -1000 | -2691 | 1284 |
| ITGA3 | 4809 | -5450 | 2976 | 557 |
| ITGA4 | 2431 | -2840 | -5085 | 1443 |
| ITGA5 | 4033 | -4692 | 5127 | 4594 |
| ITGA6 | 1799 | -990 | -5243 | -114 |
| ITGA7 | 580 | -4661 | 2121 | -4020 |
| ITGA8 | 1156 | 4577 | 93 | 2702 |
| ITGA9 | 4154 | -5185 | 3041 | 3909 |
| ITGAM | 4572 | -2599 | 4997 | 5107 |
| ITGAV | 801 | -812 | 49 | 4981 |
| ITGAX | 1897 | -886 | 3808 | 5125 |
| ITGB1 | 891 | 945 | 4567 | 4783 |
| ITGB2 | 4906 | -107 | 4945 | 5102 |
| ITGB3 | 3693 | -485 | 4867 | 2921 |
| ITGB5 | 3604 | -2545 | -4743 | -4839 |
| ITGB6 | -3832 | 471 | -3693 | 4890 |
| ITGB8 | 4079 | 3217 | -2411 | 711 |
| JAM2 | 3444 | -5266 | -4961 | -2840 |
| JAM3 | 4578 | 1269 | -3928 | 1313 |
| LAMA2 | 3038 | -3750 | -756 | 2040 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMA4 | 4388 | 736 | -121 | 2343 |
| LAMA5 | 3521 | -5520 | -2717 | -2028 |
| LAMB1 | 2539 | -455 | -385 | 3101 |
| LAMB2 | 3450 | -4834 | -3037 | -2486 |
| LAMB3 | 2231 | -4929 | -4569 | 386 |
| LAMC1 | 4113 | -3181 | 2501 | 4089 |
| LAMC2 | 4587 | 1336 | 5102 | 4436 |
| LOX | 4606 | 4062 | 3160 | 3765 |
| LOXL1 | 4187 | -1569 | 3956 | 4524 |
| LOXL2 | 5054 | -3017 | 2997 | 3520 |
| LOXL3 | 4563 | -1100 | 1944 | 4925 |
| LOXL4 | 3456 | 552 | 27 | 3757 |
| LRP4 | -3904 | -5103 | -4823 | -2122 |
| LTBP1 | 555 | -67 | -1267 | 4963 |
| LTBP3 | 2480 | -3134 | -2528 | -990 |
| LTBP4 | 3682 | -1659 | 2214 | 400 |
| LUM | 4580 | -1815 | 2455 | 4537 |
| MFAP1 | -2124 | 4892 | 3769 | -1986 |
| MFAP2 | 4871 | 78 | 422 | 2158 |
| MFAP3 | -1951 | 4029 | 2831 | 3634 |
| MFAP4 | 4643 | -755 | -329 | 2564 |
| MFAP5 | 4668 | -121 | 4486 | 4499 |
| MMP11 | 2889 | -3240 | -393 | 1218 |
| MMP14 | 4687 | -1668 | 1618 | 2675 |
| MMP15 | 1264 | -5090 | -5214 | -4505 |
| MMP17 | 2906 | -2335 | 5119 | 5161 |
| MMP19 | 4747 | -167 | 4806 | 5126 |
| MMP2 | 4410 | -689 | -1983 | 2240 |
| MUSK | 2918 | -3675 | 4380 | 3328 |
| NCAM1 | 3566 | -3904 | 4088 | 3898 |
| NCSTN | -1401 | -2472 | 1251 | 2905 |
| NID1 | 3391 | -1249 | 709 | 3576 |
| NID2 | 2587 | 177 | -1976 | 3644 |
| NTN4 | 4620 | -1246 | -942 | 2808 |
| P4HA1 | -1548 | -2913 | 4840 | -4372 |
| P4HA2 | 2577 | -3906 | 2007 | -2091 |
| P4HB | -184 | -2493 | 4004 | 3152 |
| PCOLCE | 4784 | -618 | 2120 | 3588 |
| PCOLCE2 | 4527 | 1723 | -52 | 4379 |
| PDGFA | 1632 | -4274 | -4407 | -2948 |
| PDGFB | 3143 | -603 | 3307 | -1238 |
| PHYKPL | 4956 | -4988 | -3912 | -2713 |
| PLEC | -3017 | -5409 | -1604 | -3459 |
| PLOD1 | 860 | -4628 | 381 | 2050 |
| PLOD2 | 3184 | 3503 | 4833 | 4022 |
| PLOD3 | 4888 | -4263 | 3018 | 4301 |
| PPIB | 4256 | -428 | 3462 | 4403 |
| PRKCA | -720 | -2900 | -2894 | -4160 |
| PSEN1 | 2583 | 2051 | 2038 | 1484 |
| PTPRS | 1732 | -4554 | -4143 | 2695 |
| PXDN | 3490 | -1421 | -3444 | 3436 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| SERPINE1 | 4636 | -210 | 5117 | 3333 |
| SERPINH1 | 4694 | -3479 | 3725 | 2554 |
| SH3PXD2A | -126 | -5007 | -3424 | 2652 |
| SPARC | 3820 | -2638 | -565 | 1957 |
| SPP1 | 4998 | 1150 | 3009 | 5215 |
| TGFB1 | 4177 | -3070 | 4895 | 4099 |
| TGFB2 | 3078 | 4561 | 1841 | -2330 |
| TGFB3 | 3860 | -5264 | -2015 | -4211 |
| THBS1 | 4954 | 752 | 4384 | 3647 |
| TIMP1 | 4933 | -1301 | 5188 | 4988 |
| TIMP2 | 4689 | -1860 | -732 | 1606 |
| TNC | 5019 | 793 | 4283 | 3460 |
| TNXB | 4386 | -65 | 2484 | 3472 |
| TRAPPC4 | 41 | 3212 | 2700 | 1401 |
| VCAM1 | 4924 | 2842 | 4665 | 4588 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Glycogen storage diseases
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00264 |
| p.adjustMANOVA | 0.00775 |
| s.dist | 0.709 |
| s.FSHD | -0.37 |
| s.hu_model | -0.407 |
| s.Watt_m | -0.0607 |
| s.Jones_m | -0.443 |
| p.FSHD | 0.0338 |
| p.hu_model | 0.0195 |
| p.Watt_m | 0.727 |
| p.Jones_m | 0.0109 |
| Gene | Jones_m | hu_model |
|---|---|---|
| SLC37A4 | -4920 | -4706 |
| GAA | -4456 | -4939 |
| GYS1 | -3594 | -5321 |
| G6PC3 | -3910 | -3026 |
| PPP1R3C | -1008 | -4953 |
| NHLRC1 | -1269 | -3408 |
| EPM2A | -5218 | -576 |
| GYG1 | -86 | -3826 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| EPM2A | -4545 | -576 | -4739 | -5218 |
| G6PC3 | 1060 | -3026 | -1478 | -3910 |
| GAA | 28 | -4939 | -3333 | -4456 |
| GBE1 | -4951 | 525 | -3398 | -528 |
| GYG1 | -3160 | -3826 | 4388 | -86 |
| GYS1 | -2080 | -5321 | -4613 | -3594 |
| NHLRC1 | -3337 | -3408 | 3873 | -1269 |
| PPP1R3C | -4164 | -4953 | 4005 | -1008 |
| RPS27A | 1292 | 773 | 1820 | 1913 |
| SLC37A4 | -3004 | -4706 | -4997 | -4920 |
| UBC | -537 | 2649 | 4433 | -2992 |
Diseases associated with glycosaminoglycan metabolism
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 1.97e-06 |
| p.adjustMANOVA | 1.41e-05 |
| s.dist | 0.708 |
| s.FSHD | 0.565 |
| s.hu_model | -0.217 |
| s.Watt_m | 0.193 |
| s.Jones_m | 0.311 |
| p.FSHD | 8.36e-08 |
| p.hu_model | 0.0397 |
| p.Watt_m | 0.067 |
| p.Jones_m | 0.00326 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SDC2 | 4456 | 5008 |
| BGN | 4348 | 5088 |
| VCAN | 4971 | 4285 |
| LUM | 4580 | 4537 |
| EXT1 | 4706 | 3717 |
| SDC3 | 3721 | 4191 |
| CHSY1 | 4080 | 3666 |
| HEXB | 2661 | 4889 |
| B3GALT6 | 3823 | 3103 |
| CHST14 | 3538 | 3049 |
| SDC1 | 3944 | 2683 |
| HEXA | 2020 | 4440 |
| OGN | 3168 | 2569 |
| HSPG2 | 2035 | 2942 |
| GPC6 | 4618 | 804 |
| AGRN | 3889 | 760 |
| B4GALT1 | 1688 | 1643 |
| SLC26A2 | 826 | 1507 |
| SDC4 | 1095 | 946 |
| B4GALT7 | 746 | 513 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| B3GALT6 | 3823 | -1236 | 4092 | 3103 |
| B3GAT3 | 4055 | -4180 | 1326 | -1191 |
| B4GALT1 | 1688 | -1298 | 2563 | 1643 |
| B4GALT7 | 746 | -4099 | -1523 | 513 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CHST14 | 3538 | -3780 | 1229 | 3049 |
| CHSY1 | 4080 | 3773 | 1890 | 3666 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| EXT1 | 4706 | 3854 | 4979 | 3717 |
| EXT2 | 2935 | 2055 | 910 | -1968 |
| FMOD | 4377 | -328 | -1283 | -1405 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| HEXA | 2020 | -220 | 1726 | 4440 |
| HEXB | 2661 | 743 | 2355 | 4889 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| KERA | 4979 | 519 | -844 | -956 |
| LUM | 4580 | -1815 | 2455 | 4537 |
| OGN | 3168 | 993 | -1826 | 2569 |
| PAPSS2 | 951 | 1700 | 378 | 208 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| SLC26A2 | 826 | 1373 | 2008 | 1507 |
| ST3GAL3 | -4430 | -4784 | -2254 | -2153 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
Condensation of Prophase Chromosomes
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000632 |
| p.adjustMANOVA | 0.00224 |
| s.dist | 0.706 |
| s.FSHD | -0.153 |
| s.hu_model | 0.373 |
| s.Watt_m | 0.188 |
| s.Jones_m | 0.548 |
| p.FSHD | 0.38 |
| p.hu_model | 0.0321 |
| p.Watt_m | 0.279 |
| p.Jones_m | 0.00167 |
| Gene | Jones_m | hu_model |
|---|---|---|
| SMC4 | 3733 | 4094 |
| NCAPD3 | 4711 | 2977 |
| SMC2 | 5025 | 2455 |
| H2AFX | 4862 | 2335 |
| CDK1 | 4727 | 1563 |
| MCPH1 | 1875 | 2156 |
| PHF8 | 435 | 3366 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CDK1 | 346 | 1563 | 3225 | 4727 |
| H2AFX | 1120 | 2335 | 5014 | 4862 |
| MCPH1 | -5201 | 2156 | -1835 | 1875 |
| NCAPD3 | 847 | 2977 | -4842 | 4711 |
| NCAPG2 | 349 | -13 | 1143 | 4767 |
| NCAPH2 | -561 | -1821 | -2801 | -1811 |
| PHF8 | 526 | 3366 | 2113 | 435 |
| RB1 | -2663 | -2417 | 1448 | 5214 |
| SET | -1958 | 3653 | 2107 | -2226 |
| SMC2 | -371 | 2455 | 3726 | 5025 |
| SMC4 | -3282 | 4094 | 1087 | 3733 |
Postmitotic nuclear pore complex (NPC) reformation
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 1.7e-06 |
| p.adjustMANOVA | 1.23e-05 |
| s.dist | 0.705 |
| s.FSHD | -0.187 |
| s.hu_model | 0.544 |
| s.Watt_m | 0.351 |
| s.Jones_m | 0.208 |
| p.FSHD | 0.114 |
| p.hu_model | 4.01e-06 |
| p.Watt_m | 0.00297 |
| p.Jones_m | 0.0772 |
| Gene | hu_model | Watt_m |
|---|---|---|
| NUP98 | 4201 | 5018 |
| NUP54 | 4471 | 3788 |
| TNPO1 | 3157 | 5079 |
| NUP205 | 4401 | 3546 |
| KPNB1 | 3591 | 3475 |
| NUP43 | 4522 | 2192 |
| NUP107 | 3205 | 2916 |
| NUP188 | 2098 | 3787 |
| SUMO1 | 4179 | 1384 |
| SEH1L | 1073 | 4219 |
| RAN | 2308 | 1918 |
| NUP160 | 3965 | 1024 |
| RCC1 | 986 | 3577 |
| NUP35 | 4530 | 641 |
| RANGAP1 | 478 | 4294 |
| UBE2I | 1232 | 1203 |
| SEC13 | 721 | 1683 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AHCTF1 | -5298 | 4621 | -1774 | -4269 |
| KPNB1 | -3838 | 3591 | 3475 | 1881 |
| NDC1 | 618 | 1259 | -2329 | 470 |
| NUP107 | 900 | 3205 | 2916 | 3187 |
| NUP133 | -5319 | 878 | -4004 | -4497 |
| NUP155 | -4100 | 4271 | -2213 | -1602 |
| NUP160 | 571 | 3965 | 1024 | -107 |
| NUP188 | 2427 | 2098 | 3787 | 3045 |
| NUP205 | -4103 | 4401 | 3546 | 3230 |
| NUP35 | -4243 | 4530 | 641 | 2545 |
| NUP37 | -5311 | -326 | 189 | -1501 |
| NUP43 | -1288 | 4522 | 2192 | 118 |
| NUP54 | -3175 | 4471 | 3788 | 1839 |
| NUP85 | 2367 | 3154 | -391 | -1193 |
| NUP93 | 3230 | -1483 | 3860 | 4885 |
| NUP98 | -2852 | 4201 | 5018 | 2583 |
| RAN | 166 | 2308 | 1918 | 385 |
| RANGAP1 | 2817 | 478 | 4294 | 3126 |
| RCC1 | 2015 | 986 | 3577 | 2530 |
| SEC13 | -607 | 721 | 1683 | 165 |
| SEH1L | -254 | 1073 | 4219 | 2743 |
| SUMO1 | -3179 | 4179 | 1384 | -466 |
| TNPO1 | 296 | 3157 | 5079 | 3196 |
| UBE2I | 253 | 1232 | 1203 | 3159 |
Processing of SMDT1
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00249 |
| p.adjustMANOVA | 0.00738 |
| s.dist | 0.703 |
| s.FSHD | -0.584 |
| s.hu_model | 0.149 |
| s.Watt_m | -0.268 |
| s.Jones_m | -0.244 |
| p.FSHD | 9.01e-05 |
| p.hu_model | 0.318 |
| p.Watt_m | 0.0729 |
| p.Jones_m | 0.101 |
| Gene | FSHD | Watt_m |
|---|---|---|
| PMPCB | -5065 | -3599 |
| AFG3L2 | -4583 | -3074 |
| PMPCA | -3040 | -4554 |
| SPG7 | -3269 | -3652 |
| MICU3 | -4344 | -2525 |
| YME1L1 | -5076 | -2155 |
| PHB | -3242 | -2096 |
| PHB2 | -3483 | -889 |
| C2orf47 | -4691 | -472 |
| SMDT1 | -2173 | -157 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AFG3L2 | -4583 | -1974 | -3074 | -1568 |
| C2orf47 | -4691 | 4125 | -472 | -2251 |
| MCU | -820 | 416 | 1521 | 4976 |
| MICU1 | -1998 | 4883 | 2372 | 3567 |
| MICU2 | -4462 | -606 | 1264 | 3704 |
| MICU3 | -4344 | 2577 | -2525 | -4758 |
| PARL | 220 | 762 | -4126 | -2890 |
| PHB | -3242 | -583 | -2096 | -4330 |
| PHB2 | -3483 | 584 | -889 | -1389 |
| PMPCA | -3040 | -92 | -4554 | -4811 |
| PMPCB | -5065 | -824 | -3599 | -1223 |
| SMDT1 | -2173 | -3739 | -157 | 1060 |
| SPG7 | -3269 | -4482 | -3652 | -4377 |
| STOML2 | -2788 | 1967 | 314 | -3383 |
| YME1L1 | -5076 | 4303 | -2155 | -2146 |
GPVI-mediated activation cascade
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.00388 |
| p.adjustMANOVA | 0.0109 |
| s.dist | 0.701 |
| s.FSHD | 0.235 |
| s.hu_model | 0.16 |
| s.Watt_m | 0.461 |
| s.Jones_m | 0.444 |
| p.FSHD | 0.084 |
| p.hu_model | 0.241 |
| p.Watt_m | 0.000703 |
| p.Jones_m | 0.00111 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| PTPN6 | 4751 | 5055 |
| RAC2 | 4898 | 4759 |
| PDPN | 4537 | 4445 |
| RHOG | 4878 | 3843 |
| LYN | 3940 | 4433 |
| RHOA | 4149 | 3875 |
| FYN | 3642 | 4010 |
| RHOB | 5078 | 2440 |
| CDC42 | 746 | 2621 |
| PIK3R3 | 569 | 3244 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CDC42 | 1017 | 3281 | 746 | 2621 |
| FYN | 4466 | -2813 | 3642 | 4010 |
| LYN | 3429 | 775 | 3940 | 4433 |
| PDPK1 | -3714 | 3416 | 2198 | -1065 |
| PDPN | -52 | -3260 | 4537 | 4445 |
| PIK3CA | -2357 | 362 | 2782 | -3797 |
| PIK3CB | -3283 | 2736 | 4946 | -128 |
| PIK3R1 | -5317 | 2872 | -3114 | 468 |
| PIK3R3 | 3206 | 3161 | 569 | 3244 |
| PTPN11 | -1703 | -1554 | -660 | -1108 |
| PTPN6 | 3645 | -920 | 4751 | 5055 |
| RAC1 | -458 | 2502 | 1441 | -618 |
| RAC2 | 2914 | 39 | 4898 | 4759 |
| RHOA | 2232 | 532 | 4149 | 3875 |
| RHOB | 3771 | 4568 | 5078 | 2440 |
| RHOG | 3718 | -1192 | 4878 | 3843 |
| VAV2 | 4713 | -4898 | -893 | 3870 |
| VAV3 | 2792 | 184 | -1056 | 5070 |
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0497 |
| p.adjustMANOVA | 0.0906 |
| s.dist | 0.7 |
| s.FSHD | -0.198 |
| s.hu_model | -0.379 |
| s.Watt_m | -0.426 |
| s.Jones_m | -0.356 |
| p.FSHD | 0.278 |
| p.hu_model | 0.0382 |
| p.Watt_m | 0.0198 |
| p.Jones_m | 0.0512 |
| Gene | Watt_m | hu_model |
|---|---|---|
| PRKAG3 | -5227 | -5473 |
| PPARGC1A | -4951 | -4158 |
| PRKAA2 | -5106 | -3176 |
| PRKAG2 | -3494 | -3194 |
| PRKAB2 | -2793 | -2300 |
| MAPK14 | -1619 | -1541 |
| MAPK11 | -331 | -3339 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| MAPK11 | 4482 | -3339 | -331 | 383 |
| MAPK12 | -2405 | -5202 | 636 | -4819 |
| MAPK14 | -3218 | -1541 | -1619 | -4979 |
| PPARGC1A | -2174 | -4158 | -4951 | 1255 |
| PRKAA2 | -3931 | -3176 | -5106 | -4407 |
| PRKAB1 | 2454 | 3409 | 1794 | 2829 |
| PRKAB2 | -2523 | -2300 | -2793 | -5257 |
| PRKAG1 | -3078 | 2084 | -1788 | -2783 |
| PRKAG2 | -382 | -3194 | -3494 | 2548 |
| PRKAG3 | -1474 | -5473 | -5227 | -3870 |
Heparan sulfate/heparin (HS-GAG) metabolism
| metric | value |
|---|---|
| setSize | 34 |
| pMANOVA | 3.73e-07 |
| p.adjustMANOVA | 3.32e-06 |
| s.dist | 0.695 |
| s.FSHD | 0.537 |
| s.hu_model | -0.272 |
| s.Watt_m | 0.173 |
| s.Jones_m | 0.3 |
| p.FSHD | 5.94e-08 |
| p.hu_model | 0.00601 |
| p.Watt_m | 0.0804 |
| p.Jones_m | 0.00248 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SDC2 | 4456 | 5008 |
| BGN | 4348 | 5088 |
| VCAN | 4971 | 4285 |
| GUSB | 4047 | 5097 |
| EXT1 | 4706 | 3717 |
| SDC3 | 3721 | 4191 |
| GLB1L | 4309 | 3448 |
| GLB1 | 3757 | 3737 |
| NAGLU | 3005 | 4335 |
| SGSH | 3076 | 3931 |
| B3GALT6 | 3823 | 3103 |
| HS6ST2 | 2263 | 5065 |
| SLC35D2 | 4063 | 2705 |
| SDC1 | 3944 | 2683 |
| IDS | 1662 | 4417 |
| HSPG2 | 2035 | 2942 |
| GPC6 | 4618 | 804 |
| AGRN | 3889 | 760 |
| XYLT2 | 2228 | 1093 |
| GLCE | 611 | 2011 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| AGRN | 3889 | -4843 | -2922 | 760 |
| B3GALT6 | 3823 | -1236 | 4092 | 3103 |
| B3GAT3 | 4055 | -4180 | 1326 | -1191 |
| B4GALT7 | 746 | -4099 | -1523 | 513 |
| BGN | 4348 | -1456 | 3875 | 5088 |
| CSPG4 | 3730 | -5557 | 531 | -99 |
| DCN | 4452 | -1036 | -890 | -1620 |
| EXT1 | 4706 | 3854 | 4979 | 3717 |
| EXT2 | 2935 | 2055 | 910 | -1968 |
| GLB1 | 3757 | -2214 | 915 | 3737 |
| GLB1L | 4309 | -1803 | -412 | 3448 |
| GLCE | 611 | 3934 | 3950 | 2011 |
| GPC1 | -1704 | -5207 | -2934 | -1700 |
| GPC4 | -587 | -5108 | -3461 | -1575 |
| GPC6 | 4618 | -2353 | 156 | 804 |
| GUSB | 4047 | 1905 | 4109 | 5097 |
| HS2ST1 | 1636 | 1665 | 2475 | -1244 |
| HS3ST5 | -3043 | -1621 | -1199 | -5303 |
| HS6ST1 | -1736 | -2492 | 5088 | 2340 |
| HS6ST2 | 2263 | -4491 | 273 | 5065 |
| HSPG2 | 2035 | -5289 | -401 | 2942 |
| IDS | 1662 | -2441 | -3581 | 4417 |
| IDUA | 4027 | -3817 | -4684 | 75 |
| NAGLU | 3005 | -3661 | -707 | 4335 |
| NDST1 | 936 | -3038 | -3033 | -2695 |
| SDC1 | 3944 | -2017 | 209 | 2683 |
| SDC2 | 4456 | 1739 | 4436 | 5008 |
| SDC3 | 3721 | -4560 | 2780 | 4191 |
| SDC4 | 1095 | -2361 | 5103 | 946 |
| SGSH | 3076 | 701 | -507 | 3931 |
| SLC35D2 | 4063 | -2826 | 1777 | 2705 |
| VCAN | 4971 | 1662 | 4386 | 4285 |
| XYLT1 | 3695 | 2589 | 2917 | -2537 |
| XYLT2 | 2228 | -1124 | 1315 | 1093 |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
| metric | value |
|---|---|
| setSize | 65 |
| pMANOVA | 2.15e-13 |
| p.adjustMANOVA | 5.63e-12 |
| s.dist | 0.694 |
| s.FSHD | 0.557 |
| s.hu_model | -0.0937 |
| s.Watt_m | 0.169 |
| s.Jones_m | 0.367 |
| p.FSHD | 8.07e-15 |
| p.hu_model | 0.192 |
| p.Watt_m | 0.0188 |
| p.Jones_m | 3.29e-07 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SPP1 | 4998 | 5215 |
| TIMP1 | 4933 | 4988 |
| FAM20A | 4935 | 4942 |
| SDC2 | 4456 | 5008 |
| SHISA5 | 4734 | 4670 |
| VCAN | 4971 | 4285 |
| CKAP4 | 4586 | 4360 |
| IGFBP4 | 4241 | 4649 |
| APP | 3990 | 4891 |
| C3 | 4737 | 4049 |
| FN1 | 4783 | 4002 |
| FSTL1 | 4592 | 4104 |
| APOE | 3947 | 4717 |
| LGALS1 | 3933 | 4634 |
| CSF1 | 4653 | 3814 |
| IGF2 | 3751 | 4708 |
| TNC | 5019 | 3460 |
| LAMC1 | 4113 | 4089 |
| FUCA2 | 3762 | 4218 |
| HSP90B1 | 3464 | 4544 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADAM10 | 2507 | -1489 | -1018.0 | 3455.0 |
| ANO8 | -2885 | -2337 | -5040.0 | -3537.0 |
| APLP2 | 3574 | 1301 | -569.0 | -816.0 |
| APOE | 3947 | -1411 | -88.0 | 4717.0 |
| APOL1 | 5079 | 1818 | -2495.5 | -690.5 |
| APP | 3990 | -2756 | 574.0 | 4891.0 |
| BMP4 | 2116 | 329 | 908.0 | 307.0 |
| C3 | 4737 | 4276 | 1818.0 | 4049.0 |
| CALU | -927 | 3219 | 4824.0 | 4008.0 |
| CDH2 | 2915 | 599 | -268.0 | 4575.0 |
| CKAP4 | 4586 | -3769 | 4592.0 | 4360.0 |
| CSF1 | 4653 | -4188 | 4312.0 | 3814.0 |
| CYR61 | 2129 | 1076 | 4962.0 | 3481.0 |
| DNAJC3 | 2002 | 1932 | 1321.0 | 729.0 |
| EVA1A | 1031 | 654 | 2986.0 | -1047.0 |
| FAM20A | 4935 | -1723 | 1537.0 | 4942.0 |
| FAM20C | 2832 | -5416 | 1698.0 | 2083.0 |
| FBN1 | 4504 | 636 | 3601.0 | 2988.0 |
| FN1 | 4783 | 33 | 3978.0 | 4002.0 |
| FSTL1 | 4592 | 1443 | 3660.0 | 4104.0 |
| FUCA2 | 3762 | -2131 | -4136.0 | 4218.0 |
| GAS6 | 1347 | -4951 | -3118.0 | 4035.0 |
| GOLM1 | 3066 | 1461 | -1602.0 | -3332.0 |
| HRC | -1857 | -4700 | -4971.0 | -4363.0 |
| HSP90B1 | 3464 | 456 | 4896.0 | 4544.0 |
| IGF2 | 3751 | -4694 | -2998.0 | 4708.0 |
| IGFBP3 | 2320 | 2898 | -4792.0 | -2376.0 |
| IGFBP4 | 4241 | -308 | 2374.0 | 4649.0 |
| IGFBP5 | 759 | -5367 | -5313.0 | 1564.0 |
| IGFBP6 | 4675 | -1958 | 1566.0 | -1497.0 |
| IGFBP7 | 3664 | 500 | 1346.0 | 3683.0 |
| KTN1 | -4560 | 1411 | -1533.0 | 2648.0 |
| LAMB1 | 2539 | -455 | -385.0 | 3101.0 |
| LAMB2 | 3450 | -4834 | -3037.0 | -2486.0 |
| LAMC1 | 4113 | -3181 | 2501.0 | 4089.0 |
| LGALS1 | 3933 | -4021 | 1865.0 | 4634.0 |
| LTBP1 | 555 | -67 | -1267.0 | 4963.0 |
| MBTPS1 | 1045 | -3785 | -2964.0 | 358.0 |
| MEN1 | 3596 | 1333 | 2467.0 | 1939.0 |
| MFGE8 | 2123 | -2870 | 4847.0 | -1422.0 |
| MGAT4A | 2876 | 265 | 3278.0 | 943.0 |
| MIA3 | -3311 | 2906 | -3524.0 | -2382.0 |
| MMP2 | 4410 | -689 | -1983.0 | 2240.0 |
| MXRA8 | 4710 | -3829 | -1251.0 | 801.0 |
| NUCB1 | 1327 | -4026 | 1564.0 | 4017.0 |
| P4HB | -184 | -2493 | 4004.0 | 3152.0 |
| PDIA6 | 1211 | -110 | 5042.0 | 4192.0 |
| PENK | 4673 | 625 | -2141.0 | -1988.0 |
| PNPLA2 | 1605 | -4949 | -4831.0 | -2696.0 |
| PRKCSH | 3145 | -267 | 532.0 | 4720.0 |
| PRSS23 | 2962 | 3908 | 864.0 | -4834.0 |
| QSOX1 | 678 | 2026 | 2964.0 | 4617.0 |
| RCN1 | 3972 | 1882 | 3387.0 | 3797.0 |
| SDC2 | 4456 | 1739 | 4436.0 | 5008.0 |
| SHISA5 | 4734 | -1707 | 4521.0 | 4670.0 |
| SPARCL1 | 2798 | -800 | -4717.0 | -3494.0 |
| SPP1 | 4998 | 1150 | 3009.0 | 5215.0 |
| STC2 | 2900 | -4655 | 3143.0 | -4693.0 |
| TGOLN2 | 1572 | 2925 | 1277.0 | 2519.0 |
| TIMP1 | 4933 | -1301 | 5188.0 | 4988.0 |
| TMEM132A | -971 | 1292 | 593.0 | 4220.0 |
| TNC | 5019 | 793 | 4283.0 | 3460.0 |
| VCAN | 4971 | 1662 | 4386.0 | 4285.0 |
| VWA1 | 4411 | -3948 | 775.0 | -2565.0 |
| WFS1 | 2862 | -2541 | 2538.0 | -1791.0 |
EGR2 and SOX10-mediated initiation of Schwann cell myelination
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 6.74e-05 |
| p.adjustMANOVA | 0.000322 |
| s.dist | 0.689 |
| s.FSHD | 0.179 |
| s.hu_model | -0.422 |
| s.Watt_m | 0.311 |
| s.Jones_m | 0.409 |
| p.FSHD | 0.167 |
| p.hu_model | 0.00108 |
| p.Watt_m | 0.0162 |
| p.Jones_m | 0.00155 |
| Gene | hu_model | Jones_m |
|---|---|---|
| DAG1 | -5174 | 4271 |
| NAB2 | -5261 | 2780 |
| NAB1 | -3059 | 4493 |
| LAMC1 | -3181 | 4089 |
| DRP2 | -3953 | 3025 |
| WWTR1 | -2471 | 4765 |
| EGR2 | -3698 | 3020 |
| SMARCA4 | -3825 | 2758 |
| TEAD1 | -4238 | 2380 |
| LAMA2 | -3750 | 2040 |
| SREBF2 | -4643 | 1416 |
| MBP | -2383 | 1599 |
| CYP51A1 | -1693 | 1505 |
| UTRN | -3592 | 700 |
| PMP22 | -1275 | 1539 |
| PRX | -2535 | 663 |
| LAMB1 | -455 | 3101 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| CYP51A1 | 1436 | -1693 | 4999 | 1505 |
| DAG1 | -4941 | -5174 | 2661 | 4271 |
| DRP2 | 885 | -3953 | 504 | 3025 |
| EGR2 | 5000 | -3698 | 5027 | 3020 |
| HDAC2 | -2232 | 4350 | -1093 | -2901 |
| HMGCR | -1171 | 960 | 4584 | 3959 |
| LAMA2 | 3038 | -3750 | -756 | 2040 |
| LAMB1 | 2539 | -455 | -385 | 3101 |
| LAMC1 | 4113 | -3181 | 2501 | 4089 |
| MBP | -4293 | -2383 | 1140 | 1599 |
| NAB1 | 3443 | -3059 | 2596 | 4493 |
| NAB2 | 4732 | -5261 | 4372 | 2780 |
| PMP22 | 2803 | -1275 | 1627 | 1539 |
| PRX | -860 | -2535 | 1467 | 663 |
| SMARCA4 | 634 | -3825 | -1390 | 2758 |
| SREBF2 | -496 | -4643 | 4470 | 1416 |
| TEAD1 | -4942 | -4238 | -1861 | 2380 |
| UTRN | 1484 | -3592 | -3351 | 700 |
| WWTR1 | 3398 | -2471 | 801 | 4765 |
| YAP1 | 602 | -474 | 3820 | -2892 |
Assembly of collagen fibrils and other multimeric structures
| metric | value |
|---|---|
| setSize | 42 |
| pMANOVA | 4.73e-10 |
| p.adjustMANOVA | 6.68e-09 |
| s.dist | 0.688 |
| s.FSHD | 0.506 |
| s.hu_model | -0.284 |
| s.Watt_m | 0.00267 |
| s.Jones_m | 0.37 |
| p.FSHD | 1.42e-08 |
| p.hu_model | 0.00146 |
| p.Watt_m | 0.976 |
| p.Jones_m | 3.32e-05 |
| Gene | FSHD | Jones_m |
|---|---|---|
| LOXL3 | 4563 | 4925 |
| COL8A1 | 4315 | 5058 |
| LAMC2 | 4587 | 4436 |
| CTSS | 3773 | 5148 |
| LOXL1 | 4187 | 4524 |
| COL5A2 | 4413 | 4122 |
| CD151 | 4172 | 4305 |
| LOXL2 | 5054 | 3520 |
| LOX | 4606 | 3765 |
| PCOLCE | 4784 | 3588 |
| COL3A1 | 4565 | 3575 |
| COL6A3 | 4171 | 3393 |
| BMP1 | 3427 | 4072 |
| COL6A2 | 4692 | 2927 |
| COL6A1 | 4823 | 2788 |
| COL18A1 | 4351 | 3090 |
| CTSB | 2843 | 4639 |
| LOXL4 | 3456 | 3757 |
| COL5A1 | 4323 | 2999 |
| COL4A2 | 3851 | 3295 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| BMP1 | 3427 | -4914 | 43 | 4072 |
| CD151 | 4172 | -5328 | -921 | 4305 |
| COL11A1 | 4414 | 2113 | -2198 | -116 |
| COL11A2 | -2800 | -2814 | -4013 | -1603 |
| COL15A1 | 2478 | -169 | 1436 | 1179 |
| COL18A1 | 4351 | -2864 | 2677 | 3090 |
| COL1A1 | 4847 | -1617 | 7 | 676 |
| COL1A2 | 4681 | -1689 | -375 | 1250 |
| COL24A1 | -3035 | -5069 | -4749 | 5120 |
| COL27A1 | 1066 | -5022 | 3972 | 2845 |
| COL3A1 | 4565 | 2950 | 2503 | 3575 |
| COL4A1 | 3805 | -4695 | 688 | 3236 |
| COL4A2 | 3851 | -4973 | 861 | 3295 |
| COL4A3 | -2253 | -3782 | -4833 | -1934 |
| COL4A4 | -2804 | -2983 | -3940 | -28 |
| COL4A5 | -4216 | -4266 | -3428 | -289 |
| COL5A1 | 4323 | -1537 | 2338 | 2999 |
| COL5A2 | 4413 | -2991 | 3064 | 4122 |
| COL5A3 | 3094 | -1534 | 3807 | 1554 |
| COL6A1 | 4823 | -1919 | 2015 | 2788 |
| COL6A2 | 4692 | -1812 | 2344 | 2927 |
| COL6A3 | 4171 | -119 | 2648 | 3393 |
| COL6A6 | 1139 | -2109 | -3933 | 45 |
| COL7A1 | -425 | -3189 | -3985 | -2664 |
| COL8A1 | 4315 | 881 | 4752 | 5058 |
| COL8A2 | 4912 | -457 | -2292 | -563 |
| CTSB | 2843 | -1183 | -789 | 4639 |
| CTSS | 3773 | -338 | 5035 | 5148 |
| CTSV | -84 | 2189 | 34 | 331 |
| DST | -3834 | -1727 | -4289 | -4863 |
| ITGA6 | 1799 | -990 | -5243 | -114 |
| LAMA3 | 3451 | -999 | -4332 | -2201 |
| LAMB3 | 2231 | -4929 | -4569 | 386 |
| LAMC2 | 4587 | 1336 | 5102 | 4436 |
| LOX | 4606 | 4062 | 3160 | 3765 |
| LOXL1 | 4187 | -1569 | 3956 | 4524 |
| LOXL2 | 5054 | -3017 | 2997 | 3520 |
| LOXL3 | 4563 | -1100 | 1944 | 4925 |
| LOXL4 | 3456 | 552 | 27 | 3757 |
| PCOLCE | 4784 | -618 | 2120 | 3588 |
| PLEC | -3017 | -5409 | -1604 | -3459 |
| PXDN | 3490 | -1421 | -3444 | 3436 |
Synthesis of bile acids and bile salts
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.007 |
| p.adjustMANOVA | 0.0176 |
| s.dist | 0.687 |
| s.FSHD | -0.392 |
| s.hu_model | -0.0986 |
| s.Watt_m | -0.395 |
| s.Jones_m | -0.391 |
| p.FSHD | 0.004 |
| p.hu_model | 0.469 |
| p.Watt_m | 0.0037 |
| p.Jones_m | 0.00413 |
| Gene | Watt_m | FSHD |
|---|---|---|
| CYP27A1 | -5277 | -5269 |
| SCP2 | -4882 | -5322 |
| OSBPL1A | -4753 | -4645 |
| RXRA | -4147 | -4228 |
| OSBPL9 | -4648 | -3420 |
| AMACR | -4008 | -3399 |
| HSD17B4 | -3004 | -4299 |
| NCOA2 | -4995 | -2521 |
| OSBPL6 | -5101 | -1996 |
| OSBP | -1243 | -4893 |
| NCOA1 | -1158 | -2128 |
| CYP39A1 | -1247 | -1308 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ACOT8 | -2551 | -946 | 417 | 820 |
| AMACR | -3399 | 4127 | -4008 | 40 |
| CYP27A1 | -5269 | -4450 | -5277 | -5087 |
| CYP39A1 | -1308 | 1651 | -1247 | -2478 |
| HSD17B4 | -4299 | 680 | -3004 | -3754 |
| HSD3B7 | 4131 | -4317 | 1041 | 2290 |
| NCOA1 | -2128 | 2605 | -1158 | -3029 |
| NCOA2 | -2521 | 143 | -4995 | -4281 |
| OSBP | -4893 | 2376 | -1243 | -4260 |
| OSBPL1A | -4645 | -2922 | -4753 | -3878 |
| OSBPL2 | 1819 | -4677 | -3391 | -1830 |
| OSBPL3 | -4049 | -3458 | 4659 | 5209 |
| OSBPL6 | -1996 | 4551 | -5101 | -4902 |
| OSBPL7 | 269 | -5523 | 2530 | -583 |
| OSBPL9 | -3420 | 3692 | -4648 | -4997 |
| PTGIS | 3434 | -1895 | 927 | 1214 |
| RXRA | -4228 | -5455 | -4147 | -5038 |
| SCP2 | -5322 | -854 | -4882 | -3079 |
Heme biosynthesis
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0148 |
| p.adjustMANOVA | 0.0323 |
| s.dist | 0.686 |
| s.FSHD | -0.132 |
| s.hu_model | -0.127 |
| s.Watt_m | -0.58 |
| s.Jones_m | -0.317 |
| p.FSHD | 0.429 |
| p.hu_model | 0.445 |
| p.Watt_m | 0.000499 |
| p.Jones_m | 0.0577 |
| Gene | Watt_m | Jones_m |
|---|---|---|
| ALAS1 | -4662 | -3557 |
| UROS | -4368 | -3793 |
| CPOX | -3532 | -3818 |
| UROD | -3208 | -3454 |
| ALAD | -3590 | -2479 |
| FLVCR1 | -4625 | -1867 |
| COX15 | -5153 | -1164 |
| FECH | -4097 | -1024 |
| HMBS | -1585 | -2365 |
| COX10 | -3678 | -199 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ABCG2 | 4473 | -2433 | 4905 | 2385 |
| ALAD | 58 | -3806 | -3590 | -2479 |
| ALAS1 | -3427 | 3203 | -4662 | -3557 |
| COX10 | -3212 | 2711 | -3678 | -199 |
| COX15 | -2709 | 562 | -5153 | -1164 |
| CPOX | -3627 | -857 | -3532 | -3818 |
| FECH | -3784 | -3719 | -4097 | -1024 |
| FLVCR1 | 4000 | 1415 | -4625 | -1867 |
| HMBS | -3597 | -3907 | -1585 | -2365 |
| PPOX | 2819 | -3736 | -3635 | 915 |
| UROD | -94 | 785 | -3208 | -3454 |
| UROS | -1409 | -1824 | -4368 | -3793 |
Post-translational protein phosphorylation
| metric | value |
|---|---|
| setSize | 62 |
| pMANOVA | 4.3e-12 |
| p.adjustMANOVA | 9.12e-11 |
| s.dist | 0.686 |
| s.FSHD | 0.543 |
| s.hu_model | -0.0784 |
| s.Watt_m | 0.187 |
| s.Jones_m | 0.367 |
| p.FSHD | 1.48e-13 |
| p.hu_model | 0.287 |
| p.Watt_m | 0.011 |
| p.Jones_m | 5.9e-07 |
| Gene | FSHD | Jones_m |
|---|---|---|
| SPP1 | 4998 | 5215 |
| TIMP1 | 4933 | 4988 |
| FAM20A | 4935 | 4942 |
| SDC2 | 4456 | 5008 |
| SHISA5 | 4734 | 4670 |
| VCAN | 4971 | 4285 |
| CKAP4 | 4586 | 4360 |
| IGFBP4 | 4241 | 4649 |
| APP | 3990 | 4891 |
| C3 | 4737 | 4049 |
| FN1 | 4783 | 4002 |
| FSTL1 | 4592 | 4104 |
| APOE | 3947 | 4717 |
| LGALS1 | 3933 | 4634 |
| CSF1 | 4653 | 3814 |
| TNC | 5019 | 3460 |
| LAMC1 | 4113 | 4089 |
| FUCA2 | 3762 | 4218 |
| HSP90B1 | 3464 | 4544 |
| RCN1 | 3972 | 3797 |
Click HERE to show all gene set members
| FSHD | hu_model | Watt_m | Jones_m | |
|---|---|---|---|---|
| ADAM10 | 2507 | -1489 | -1018.0 | 3455.0 |
| ANO8 | -2885 | -2337 | -5040.0 | -3537.0 |
| APLP2 | 3574 | 1301 | -569.0 | -816.0 |
| APOE | 3947 | -1411 | -88.0 | 4717.0 |
| APOL1 | 5079 | 1818 | -2495.5 | -690.5 |
| APP | 3990 | -2756 | 574.0 | 4891.0 |
| BMP4 | 2116 | 329 | 908.0 | 307.0 |
| C3 | 4737 | 4276 | 1818.0 | 4049.0 |
| CALU | -927 | 3219 | 4824.0 | 4008.0 |
| CDH2 | 2915 | 599 | -268.0 | 4575.0 |
| CKAP4 | 4586 | -3769 | 4592.0 | 4360.0 |
| CSF1 | 4653 | -4188 | 4312.0 | 3814.0 |
| CYR61 | 2129 | 1076 | 4962.0 | 3481.0 |
| DNAJC3 | 2002 | 1932 | 1321.0 | 729.0 |
| EVA1A | 1031 | 654 | 2986.0 | -1047.0 |
| FAM20A | 4935 | -1723 | 1537.0 | 4942.0 |
| FAM20C | 2832 | -5416 | 1698.0 | 2083.0 |
| FBN1 | 4504 | 636 | 3601.0 | 2988.0 |
| FN1 | 4783 | 33 | 3978.0 | 4002.0 |
| FSTL1 | 4592 | 1443 | 3660.0 | 4104.0 |
| FUCA2 | 3762 | -2131 | -4136.0 | 4218.0 |
| GAS6 | 1347 | -4951 | -3118.0 | 4035.0 |
| GOLM1 | 3066 | 1461 | -1602.0 | -3332.0 |
| HRC | -1857 | -4700 | -4971.0 | -4363.0 |
| HSP90B1 | 3464 | 456 | 4896.0 | 4544.0 |
| IGFBP3 | 2320 | 2898 | -4792.0 | -2376.0 |
| IGFBP4 | 4241 | -308 | 2374.0 | 4649.0 |
| IGFBP5 | 759 | -5367 | -5313.0 | 1564.0 |
| IGFBP7 | 3664 | 500 | 1346.0 | 3683.0 |
| KTN1 | -4560 | 1411 | -1533.0 | 2648.0 |
| LAMB1 | 2539 | -455 | -385.0 | 3101.0 |
| LAMB2 | 3450 | -4834 | -3037.0 | -2486.0 |
| LAMC1 | 4113 | -3181 | 2501.0 | 4089.0 |
| LGALS1 | 3933 | -4021 | 1865.0 | 4634.0 |
| LTBP1 | 555 | -67 | -1267.0 | 4963.0 |
| MBTPS1 | 1045 | -3785 | -2964.0 | 358.0 |
| MEN1 | 3596 | 1333 | 2467.0 | 1939.0 |
| MFGE8 | 2123 | -2870 | 4847.0 | -1422.0 |
| MGAT4A | 2876 | 265 | 3278.0 | 943.0 |
| MIA3 | -3311 | 2906 | -3524.0 | -2382.0 |
| MXRA8 | 4710 | -3829 | -1251.0 | 801.0 |
| NUCB1 | 1327 | -4026 | 1564.0 | 4017.0 |
| P4HB | -184 | -2493 | 4004.0 | 3152.0 |
| PDIA6 | 1211 | -110 | 5042.0 | 4192.0 |
| PENK | 4673 | 625 | -2141.0 | -1988.0 |
| PNPLA2 | 1605 | -4949 | -4831.0 | -2696.0 |
| PRKCSH | 3145 | -267 | 532.0 | 4720.0 |
| PRSS23 | 2962 | 3908 | 864.0 | -4834.0 |
| QSOX1 | 678 | 2026 | 2964.0 | 4617.0 |
| RCN1 | 3972 | 1882 | 3387.0 | 3797.0 |
| SDC2 | 4456 | 1739 | 4436.0 | 5008.0 |
| SHISA5 | 4734 | -1707 | 4521.0 | 4670.0 |
| SPARCL1 | 2798 | -800 | -4717.0 | -3494.0 |
| SPP1 | 4998 | 1150 | 3009.0 | 5215.0 |
| STC2 | 2900 | -4655 | 3143.0 | -4693.0 |
| TGOLN2 | 1572 | 2925 | 1277.0 | 2519.0 |
| TIMP1 | 4933 | -1301 | 5188.0 | 4988.0 |
| TMEM132A | -971 | 1292 | 593.0 | 4220.0 |
| TNC | 5019 | 793 | 4283.0 | 3460.0 |
| VCAN | 4971 | 1662 | 4386.0 | 4285.0 |
| VWA1 | 4411 | -3948 | 775.0 | -2565.0 |
| WFS1 | 2862 | -2541 | 2538.0 | -1791.0 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0
## [3] ggplot2_3.3.2 reshape2_1.4.4
## [5] beeswarm_0.2.3 gtools_3.8.2
## [7] tibble_3.0.4 dplyr_1.0.2
## [9] echarts4r_0.3.3 gplots_3.1.0
## [11] UpSetR_1.4.0 eulerr_6.1.0
## [13] getDEE2_1.0.0 edgeR_3.32.0
## [15] limma_3.46.0 DESeq2_1.30.0
## [17] SummarizedExperiment_1.20.0 Biobase_2.50.0
## [19] MatrixGenerics_1.2.0 matrixStats_0.57.0
## [21] GenomicRanges_1.42.0 GenomeInfoDb_1.26.0
## [23] IRanges_2.24.0 S4Vectors_0.28.0
## [25] BiocGenerics_0.36.0 mitch_1.2.2
##
## loaded via a namespace (and not attached):
## [1] bitops_1.0-6 bit64_4.0.5 progress_1.2.2
## [4] RColorBrewer_1.1-2 httr_1.4.2 rprojroot_1.3-2
## [7] backports_1.2.0 tools_4.0.3 R6_2.5.0
## [10] KernSmooth_2.23-18 DBI_1.1.0 colorspace_2.0-0
## [13] withr_2.3.0 htm2txt_2.1.1 prettyunits_1.1.1
## [16] tidyselect_1.1.0 gridExtra_2.3 bit_4.0.4
## [19] compiler_4.0.3 desc_1.2.0 DelayedArray_0.16.0
## [22] labeling_0.4.2 caTools_1.18.0 scales_1.1.1
## [25] genefilter_1.72.0 stringr_1.4.0 digest_0.6.27
## [28] rmarkdown_2.5 XVector_0.30.0 pkgconfig_2.0.3
## [31] htmltools_0.5.0 highr_0.8 fastmap_1.0.1
## [34] htmlwidgets_1.5.2 rlang_0.4.8 RSQLite_2.2.1
## [37] shiny_1.5.0 generics_0.1.0 farver_2.0.3
## [40] jsonlite_1.7.1 BiocParallel_1.24.1 RCurl_1.98-1.2
## [43] magrittr_1.5 GenomeInfoDbData_1.2.4 Matrix_1.2-18
## [46] Rcpp_1.0.5 munsell_0.5.0 lifecycle_0.2.0
## [49] yaml_2.2.1 stringi_1.5.3 MASS_7.3-53
## [52] zlibbioc_1.36.0 plyr_1.8.6 grid_4.0.3
## [55] blob_1.2.1 promises_1.1.1 crayon_1.3.4
## [58] lattice_0.20-41 splines_4.0.3 annotate_1.68.0
## [61] hms_0.5.3 polylabelr_0.2.0 locfit_1.5-9.4
## [64] knitr_1.30 pillar_1.4.6 geneplotter_1.68.0
## [67] XML_3.99-0.5 glue_1.4.2 evaluate_0.14
## [70] vctrs_0.3.4 httpuv_1.5.4 testthat_3.0.0
## [73] gtable_0.3.0 purrr_0.3.4 polyclip_1.10-0
## [76] assertthat_0.2.1 reshape_0.8.8 xfun_0.19
## [79] mime_0.9 xtable_1.8-4 later_1.1.0.1
## [82] survival_3.2-7 AnnotationDbi_1.52.0 memoise_1.1.0
## [85] ellipsis_0.3.1END of report