date generated: 2020-10-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             human        mouse
## A4GALT -14.988939  0.273897484
## AAAS    -2.435804  0.006309781
## AACS    -1.581711  5.546469568
## AAED1   -1.286093 -0.325323373
## AAGAB   -1.722220 -2.514538390
## AAK1    14.833940  1.072727148

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 10654
duplicated_genes_present 0
num_profile_genes_in_sets 6218
num_profile_genes_not_in_sets 4436
profile_pearson_correl NaN
profile_spearman_correl 0.17692

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1175
num_genesets_included 1233

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 376

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.human s.mouse p.human p.mouse
Citric acid cycle (TCA cycle) 21 1.45e-09 3.64e-08 0.833 -0.24300 -0.797 5.39e-02 2.50e-10
Mitochondrial Fatty Acid Beta-Oxidation 30 2.13e-11 7.50e-10 0.783 -0.33600 -0.708 1.48e-03 1.94e-11
Complex I biogenesis 52 2.28e-19 1.65e-17 0.765 -0.19600 -0.739 1.45e-02 2.74e-20
Respiratory electron transport 92 1.87e-31 5.78e-29 0.737 -0.17800 -0.715 3.30e-03 1.81e-32
Pyruvate metabolism and Citric Acid (TCA) cycle 49 4.72e-16 2.91e-14 0.727 -0.26300 -0.678 1.45e-03 2.15e-16
Interleukin-10 signaling 11 4.62e-05 3.56e-04 0.725 -0.25200 0.680 1.48e-01 9.46e-05
The citric acid (TCA) cycle and respiratory electron transport 142 4.45e-45 2.75e-42 0.718 -0.20200 -0.689 3.49e-05 1.02e-45
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 96 4.84e-31 1.19e-28 0.717 -0.17600 -0.695 2.89e-03 4.96e-32
p130Cas linkage to MAPK signaling for integrins 10 2.69e-04 1.72e-03 0.705 -0.14100 0.690 4.39e-01 1.56e-04
Postmitotic nuclear pore complex (NPC) reformation 24 3.90e-07 6.59e-06 0.693 0.54300 0.430 4.11e-06 2.64e-04
Cristae formation 10 5.28e-04 3.09e-03 0.689 0.05040 -0.688 7.83e-01 1.66e-04
Mitochondrial translation 87 1.80e-30 3.54e-28 0.687 0.15800 -0.668 1.08e-02 4.11e-27
Gluconeogenesis 23 9.36e-07 1.36e-05 0.687 -0.53500 -0.430 8.82e-06 3.57e-04
Mitochondrial translation elongation 81 4.11e-28 6.33e-26 0.683 0.15800 -0.664 1.39e-02 4.54e-25
Mitochondrial translation initiation 81 1.72e-27 1.77e-25 0.676 0.15200 -0.659 1.86e-02 1.12e-24
Mitochondrial translation termination 81 2.71e-27 2.57e-25 0.673 0.15600 -0.654 1.54e-02 2.28e-24
Heme biosynthesis 12 4.57e-04 2.71e-03 0.666 -0.12800 -0.654 4.44e-01 8.80e-05
Transport of Ribonucleoproteins into the Host Nucleus 25 7.08e-07 1.08e-05 0.663 0.54100 0.383 2.84e-06 9.14e-04
Glyoxylate metabolism and glycine degradation 20 4.64e-06 4.57e-05 0.660 -0.17200 -0.637 1.83e-01 8.05e-07
Post-chaperonin tubulin folding pathway 15 7.81e-06 7.24e-05 0.656 -0.48300 0.444 1.21e-03 2.89e-03
Transport of the SLBP Dependant Mature mRNA 29 1.05e-07 1.96e-06 0.652 0.55600 0.341 2.20e-07 1.48e-03
Nuclear import of Rev protein 26 6.95e-07 1.07e-05 0.650 0.53300 0.372 2.52e-06 1.03e-03
Export of Viral Ribonucleoproteins from Nucleus 26 6.72e-07 1.05e-05 0.650 0.54200 0.358 1.69e-06 1.60e-03
rRNA modification in the nucleus and cytosol 52 1.37e-13 7.04e-12 0.649 0.60000 0.247 7.07e-14 2.09e-03
Transport of the SLBP independent Mature mRNA 28 2.57e-07 4.47e-06 0.644 0.55600 0.325 3.58e-07 2.96e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 10 8.36e-04 4.54e-03 0.644 -0.20200 0.611 2.69e-01 8.20e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23 5.26e-06 4.98e-05 0.638 0.53800 0.342 7.84e-06 4.54e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 23 5.26e-06 4.98e-05 0.638 0.53800 0.342 7.84e-06 4.54e-03
Interactions of Rev with host cellular proteins 29 2.81e-07 4.81e-06 0.638 0.49900 0.398 3.39e-06 2.13e-04
Formation of tubulin folding intermediates by CCT/TriC 17 1.31e-05 1.10e-04 0.637 -0.09520 0.630 4.97e-01 6.85e-06
Pyruvate metabolism 26 8.21e-07 1.20e-05 0.629 -0.22800 -0.586 4.43e-02 2.27e-07
SUMOylation of ubiquitinylation proteins 31 1.24e-07 2.25e-06 0.629 0.53000 0.339 3.33e-07 1.11e-03
Striated Muscle Contraction 30 6.56e-08 1.33e-06 0.627 -0.60300 -0.174 1.10e-08 9.88e-02
Mitochondrial tRNA aminoacylation 18 6.03e-06 5.63e-05 0.627 0.17800 -0.601 1.90e-01 9.99e-06
SUMOylation of SUMOylation proteins 27 1.07e-06 1.47e-05 0.623 0.54200 0.307 1.08e-06 5.86e-03
NEP/NS2 Interacts with the Cellular Export Machinery 25 3.62e-06 3.78e-05 0.621 0.52500 0.332 5.54e-06 4.09e-03
Rev-mediated nuclear export of HIV RNA 28 9.94e-07 1.41e-05 0.621 0.49000 0.381 7.25e-06 4.83e-04
Signal regulatory protein family interactions 10 1.00e-03 5.32e-03 0.616 -0.41200 0.458 2.41e-02 1.22e-02
Vpr-mediated nuclear import of PICs 27 2.78e-06 2.96e-05 0.607 0.49200 0.355 9.70e-06 1.40e-03
Phase 0 - rapid depolarisation 18 1.05e-04 7.49e-04 0.603 -0.57900 -0.167 2.11e-05 2.19e-01
Mitochondrial protein import 55 5.13e-14 2.87e-12 0.602 -0.00782 -0.602 9.20e-01 1.19e-14
SUMOylation of DNA replication proteins 35 9.54e-08 1.81e-06 0.597 0.49900 0.329 3.30e-07 7.68e-04
EGR2 and SOX10-mediated initiation of Schwann cell myelination 20 2.65e-06 2.84e-05 0.594 -0.42300 0.417 1.07e-03 1.25e-03
NS1 Mediated Effects on Host Pathways 31 1.07e-06 1.47e-05 0.590 0.45100 0.379 1.37e-05 2.60e-04
Metabolism of non-coding RNA 45 4.91e-10 1.38e-08 0.588 0.55600 0.192 1.10e-10 2.58e-02
snRNP Assembly 45 4.91e-10 1.38e-08 0.588 0.55600 0.192 1.10e-10 2.58e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 6.96e-04 3.86e-03 0.588 -0.16200 -0.565 2.77e-01 1.51e-04
Branched-chain amino acid catabolism 20 4.02e-05 3.13e-04 0.585 -0.07440 -0.581 5.65e-01 6.99e-06
Role of LAT2/NTAL/LAB on calcium mobilization 11 6.39e-03 2.53e-02 0.579 0.20000 0.543 2.50e-01 1.80e-03
GPVI-mediated activation cascade 18 2.17e-04 1.43e-03 0.578 0.15900 0.556 2.42e-01 4.47e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.human s.mouse p.human p.mouse
Citric acid cycle (TCA cycle) 21 1.45e-09 3.64e-08 0.83300 -0.243000 -0.797000 5.39e-02 2.50e-10
Mitochondrial Fatty Acid Beta-Oxidation 30 2.13e-11 7.50e-10 0.78300 -0.336000 -0.708000 1.48e-03 1.94e-11
Complex I biogenesis 52 2.28e-19 1.65e-17 0.76500 -0.196000 -0.739000 1.45e-02 2.74e-20
Respiratory electron transport 92 1.87e-31 5.78e-29 0.73700 -0.178000 -0.715000 3.30e-03 1.81e-32
Pyruvate metabolism and Citric Acid (TCA) cycle 49 4.72e-16 2.91e-14 0.72700 -0.263000 -0.678000 1.45e-03 2.15e-16
Interleukin-10 signaling 11 4.62e-05 3.56e-04 0.72500 -0.252000 0.680000 1.48e-01 9.46e-05
The citric acid (TCA) cycle and respiratory electron transport 142 4.45e-45 2.75e-42 0.71800 -0.202000 -0.689000 3.49e-05 1.02e-45
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 96 4.84e-31 1.19e-28 0.71700 -0.176000 -0.695000 2.89e-03 4.96e-32
p130Cas linkage to MAPK signaling for integrins 10 2.69e-04 1.72e-03 0.70500 -0.141000 0.690000 4.39e-01 1.56e-04
Postmitotic nuclear pore complex (NPC) reformation 24 3.90e-07 6.59e-06 0.69300 0.543000 0.430000 4.11e-06 2.64e-04
Cristae formation 10 5.28e-04 3.09e-03 0.68900 0.050400 -0.688000 7.83e-01 1.66e-04
Mitochondrial translation 87 1.80e-30 3.54e-28 0.68700 0.158000 -0.668000 1.08e-02 4.11e-27
Gluconeogenesis 23 9.36e-07 1.36e-05 0.68700 -0.535000 -0.430000 8.82e-06 3.57e-04
Mitochondrial translation elongation 81 4.11e-28 6.33e-26 0.68300 0.158000 -0.664000 1.39e-02 4.54e-25
Mitochondrial translation initiation 81 1.72e-27 1.77e-25 0.67600 0.152000 -0.659000 1.86e-02 1.12e-24
Mitochondrial translation termination 81 2.71e-27 2.57e-25 0.67300 0.156000 -0.654000 1.54e-02 2.28e-24
Heme biosynthesis 12 4.57e-04 2.71e-03 0.66600 -0.128000 -0.654000 4.44e-01 8.80e-05
Transport of Ribonucleoproteins into the Host Nucleus 25 7.08e-07 1.08e-05 0.66300 0.541000 0.383000 2.84e-06 9.14e-04
Glyoxylate metabolism and glycine degradation 20 4.64e-06 4.57e-05 0.66000 -0.172000 -0.637000 1.83e-01 8.05e-07
Post-chaperonin tubulin folding pathway 15 7.81e-06 7.24e-05 0.65600 -0.483000 0.444000 1.21e-03 2.89e-03
Transport of the SLBP Dependant Mature mRNA 29 1.05e-07 1.96e-06 0.65200 0.556000 0.341000 2.20e-07 1.48e-03
Nuclear import of Rev protein 26 6.95e-07 1.07e-05 0.65000 0.533000 0.372000 2.52e-06 1.03e-03
Export of Viral Ribonucleoproteins from Nucleus 26 6.72e-07 1.05e-05 0.65000 0.542000 0.358000 1.69e-06 1.60e-03
rRNA modification in the nucleus and cytosol 52 1.37e-13 7.04e-12 0.64900 0.600000 0.247000 7.07e-14 2.09e-03
Transport of the SLBP independent Mature mRNA 28 2.57e-07 4.47e-06 0.64400 0.556000 0.325000 3.58e-07 2.96e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 10 8.36e-04 4.54e-03 0.64400 -0.202000 0.611000 2.69e-01 8.20e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23 5.26e-06 4.98e-05 0.63800 0.538000 0.342000 7.84e-06 4.54e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 23 5.26e-06 4.98e-05 0.63800 0.538000 0.342000 7.84e-06 4.54e-03
Interactions of Rev with host cellular proteins 29 2.81e-07 4.81e-06 0.63800 0.499000 0.398000 3.39e-06 2.13e-04
Formation of tubulin folding intermediates by CCT/TriC 17 1.31e-05 1.10e-04 0.63700 -0.095200 0.630000 4.97e-01 6.85e-06
Pyruvate metabolism 26 8.21e-07 1.20e-05 0.62900 -0.228000 -0.586000 4.43e-02 2.27e-07
SUMOylation of ubiquitinylation proteins 31 1.24e-07 2.25e-06 0.62900 0.530000 0.339000 3.33e-07 1.11e-03
Striated Muscle Contraction 30 6.56e-08 1.33e-06 0.62700 -0.603000 -0.174000 1.10e-08 9.88e-02
Mitochondrial tRNA aminoacylation 18 6.03e-06 5.63e-05 0.62700 0.178000 -0.601000 1.90e-01 9.99e-06
SUMOylation of SUMOylation proteins 27 1.07e-06 1.47e-05 0.62300 0.542000 0.307000 1.08e-06 5.86e-03
NEP/NS2 Interacts with the Cellular Export Machinery 25 3.62e-06 3.78e-05 0.62100 0.525000 0.332000 5.54e-06 4.09e-03
Rev-mediated nuclear export of HIV RNA 28 9.94e-07 1.41e-05 0.62100 0.490000 0.381000 7.25e-06 4.83e-04
Signal regulatory protein family interactions 10 1.00e-03 5.32e-03 0.61600 -0.412000 0.458000 2.41e-02 1.22e-02
Vpr-mediated nuclear import of PICs 27 2.78e-06 2.96e-05 0.60700 0.492000 0.355000 9.70e-06 1.40e-03
Phase 0 - rapid depolarisation 18 1.05e-04 7.49e-04 0.60300 -0.579000 -0.167000 2.11e-05 2.19e-01
Mitochondrial protein import 55 5.13e-14 2.87e-12 0.60200 -0.007820 -0.602000 9.20e-01 1.19e-14
SUMOylation of DNA replication proteins 35 9.54e-08 1.81e-06 0.59700 0.499000 0.329000 3.30e-07 7.68e-04
EGR2 and SOX10-mediated initiation of Schwann cell myelination 20 2.65e-06 2.84e-05 0.59400 -0.423000 0.417000 1.07e-03 1.25e-03
NS1 Mediated Effects on Host Pathways 31 1.07e-06 1.47e-05 0.59000 0.451000 0.379000 1.37e-05 2.60e-04
Metabolism of non-coding RNA 45 4.91e-10 1.38e-08 0.58800 0.556000 0.192000 1.10e-10 2.58e-02
snRNP Assembly 45 4.91e-10 1.38e-08 0.58800 0.556000 0.192000 1.10e-10 2.58e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 6.96e-04 3.86e-03 0.58800 -0.162000 -0.565000 2.77e-01 1.51e-04
Branched-chain amino acid catabolism 20 4.02e-05 3.13e-04 0.58500 -0.074400 -0.581000 5.65e-01 6.99e-06
Role of LAT2/NTAL/LAB on calcium mobilization 11 6.39e-03 2.53e-02 0.57900 0.200000 0.543000 2.50e-01 1.80e-03
GPVI-mediated activation cascade 18 2.17e-04 1.43e-03 0.57800 0.159000 0.556000 2.42e-01 4.47e-05
Interactions of Vpr with host cellular proteins 29 3.82e-06 3.93e-05 0.57700 0.476000 0.327000 9.21e-06 2.33e-03
Mitochondrial iron-sulfur cluster biogenesis 12 3.05e-03 1.37e-02 0.57200 -0.074800 -0.567000 6.54e-01 6.73e-04
Mitochondrial calcium ion transport 21 2.93e-05 2.35e-04 0.56900 -0.011200 -0.569000 9.29e-01 6.43e-06
Glycogen breakdown (glycogenolysis) 14 1.94e-03 9.55e-03 0.56900 -0.538000 -0.184000 4.92e-04 2.34e-01
Defective B3GAT3 causes JDSSDHD 14 3.52e-04 2.15e-03 0.56500 -0.495000 0.273000 1.35e-03 7.68e-02
MET activates RAP1 and RAC1 10 8.67e-03 3.22e-02 0.56200 0.045700 0.560000 8.03e-01 2.16e-03
Defective B3GALT6 causes EDSP2 and SEMDJL1 14 3.48e-04 2.13e-03 0.56100 -0.455000 0.329000 3.23e-03 3.32e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 36 5.04e-07 8.07e-06 0.55800 0.468000 0.302000 1.16e-06 1.70e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 60 1.03e-11 3.97e-10 0.55600 0.520000 0.197000 3.24e-12 8.32e-03
PECAM1 interactions 10 4.22e-03 1.79e-02 0.55600 -0.250000 0.497000 1.70e-01 6.54e-03
Defective B4GALT7 causes EDS, progeroid type 14 4.84e-04 2.84e-03 0.55500 -0.494000 0.254000 1.39e-03 1.00e-01
Voltage gated Potassium channels 11 9.47e-03 3.45e-02 0.54900 -0.529000 -0.150000 2.41e-03 3.89e-01
rRNA processing in the mitochondrion 11 6.65e-03 2.59e-02 0.54900 -0.037300 -0.548000 8.30e-01 1.65e-03
Transport of Mature mRNA Derived from an Intronless Transcript 35 1.18e-06 1.60e-05 0.54800 0.466000 0.288000 1.87e-06 3.20e-03
Nuclear Pore Complex (NPC) Disassembly 27 3.53e-05 2.77e-04 0.54500 0.427000 0.338000 1.24e-04 2.35e-03
SUMOylation of RNA binding proteins 38 4.94e-07 8.01e-06 0.54400 0.452000 0.303000 1.46e-06 1.24e-03
Integrin signaling 20 7.37e-05 5.48e-04 0.54200 -0.074700 0.537000 5.63e-01 3.28e-05
Viral Messenger RNA Synthesis 35 1.86e-06 2.22e-05 0.53700 0.466000 0.266000 1.85e-06 6.51e-03
Defects in cobalamin (B12) metabolism 10 7.90e-03 2.95e-02 0.53600 0.138000 -0.518000 4.49e-01 4.56e-03
Carnitine metabolism 11 1.80e-02 5.57e-02 0.53200 -0.434000 -0.308000 1.27e-02 7.69e-02
Reduction of cytosolic Ca++ levels 10 1.27e-02 4.40e-02 0.53200 -0.532000 -0.002630 3.59e-03 9.89e-01
Processing of SMDT1 15 9.53e-04 5.11e-03 0.52300 0.149000 -0.501000 3.18e-01 7.79e-04
Transport of Mature Transcript to Cytoplasm 69 1.06e-11 3.97e-10 0.52200 0.480000 0.204000 5.44e-12 3.45e-03
mRNA Splicing - Major Pathway 161 1.37e-27 1.54e-25 0.51900 0.508000 0.104000 1.02e-28 2.36e-02
Degradation of cysteine and homocysteine 12 1.65e-02 5.28e-02 0.51600 -0.303000 -0.417000 6.93e-02 1.23e-02
Processing of Capped Intron-Containing Pre-mRNA 212 5.85e-35 2.40e-32 0.51400 0.500000 0.121000 5.18e-36 2.56e-03
mRNA Splicing 169 4.96e-28 6.79e-26 0.50900 0.501000 0.092600 3.50e-29 3.86e-02
Defects in vitamin and cofactor metabolism 17 6.94e-04 3.86e-03 0.50800 0.105000 -0.497000 4.53e-01 3.89e-04
Long-term potentiation 10 1.91e-02 5.81e-02 0.50800 -0.508000 -0.010700 5.46e-03 9.53e-01
Muscle contraction 120 1.32e-19 1.02e-17 0.50200 -0.493000 -0.093400 1.12e-20 7.81e-02
CRMPs in Sema3A signaling 13 2.97e-03 1.34e-02 0.50100 -0.253000 0.432000 1.14e-01 7.02e-03
Triglyceride catabolism 13 1.47e-02 4.86e-02 0.50000 -0.275000 -0.418000 8.66e-02 9.04e-03
Regulation of KIT signaling 14 2.09e-03 1.01e-02 0.50000 -0.224000 0.446000 1.46e-01 3.85e-03
RNA Polymerase II Pre-transcription Events 69 2.02e-10 6.09e-09 0.49800 0.432000 0.247000 5.54e-10 4.05e-04
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 4.40e-02 1.10e-01 0.49400 -0.379000 -0.317000 3.79e-02 8.24e-02
HIV Transcription Initiation 40 2.16e-06 2.38e-05 0.49200 0.452000 0.194000 7.48e-07 3.39e-02
RNA Polymerase II HIV Promoter Escape 40 2.16e-06 2.38e-05 0.49200 0.452000 0.194000 7.48e-07 3.39e-02
RNA Polymerase II Promoter Escape 40 2.16e-06 2.38e-05 0.49200 0.452000 0.194000 7.48e-07 3.39e-02
RNA Polymerase II Transcription Initiation 40 2.16e-06 2.38e-05 0.49200 0.452000 0.194000 7.48e-07 3.39e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 40 2.16e-06 2.38e-05 0.49200 0.452000 0.194000 7.48e-07 3.39e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 40 2.16e-06 2.38e-05 0.49200 0.452000 0.194000 7.48e-07 3.39e-02
NCAM1 interactions 21 2.94e-04 1.85e-03 0.49000 -0.487000 0.059100 1.14e-04 6.39e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 8.83e-03 3.26e-02 0.48600 -0.360000 0.326000 3.86e-02 6.10e-02
Defective EXT2 causes exostoses 2 11 8.83e-03 3.26e-02 0.48600 -0.360000 0.326000 3.86e-02 6.10e-02
Smooth Muscle Contraction 32 4.03e-06 4.11e-05 0.48400 -0.474000 0.101000 3.58e-06 3.25e-01
Transcription of the HIV genome 59 1.08e-08 2.43e-07 0.48400 0.436000 0.210000 7.27e-09 5.32e-03
tRNA processing in the mitochondrion 11 1.77e-02 5.55e-02 0.48300 0.021200 -0.483000 9.03e-01 5.58e-03
Interaction between L1 and Ankyrins 15 7.21e-03 2.74e-02 0.48100 -0.467000 -0.115000 1.73e-03 4.40e-01
Ion homeostasis 37 1.01e-05 8.93e-05 0.48000 -0.442000 -0.188000 3.30e-06 4.85e-02
A tetrasaccharide linker sequence is required for GAG synthesis 18 6.25e-04 3.55e-03 0.47900 -0.413000 0.242000 2.41e-03 7.51e-02
Activation of Matrix Metalloproteinases 11 1.02e-02 3.65e-02 0.47900 -0.307000 0.368000 7.79e-02 3.47e-02
MET activates PTK2 signaling 15 2.25e-03 1.07e-02 0.47800 -0.419000 0.231000 5.02e-03 1.21e-01
Cyclin A/B1/B2 associated events during G2/M transition 17 6.64e-03 2.59e-02 0.47800 0.395000 0.269000 4.83e-03 5.49e-02
Response of Mtb to phagocytosis 18 5.00e-03 2.06e-02 0.47800 0.273000 0.392000 4.50e-02 4.00e-03
tRNA Aminoacylation 24 7.84e-05 5.75e-04 0.47600 0.184000 -0.438000 1.18e-01 2.01e-04
Cardiac conduction 63 3.41e-09 8.08e-08 0.47400 -0.449000 -0.152000 7.15e-10 3.75e-02
Syndecan interactions 17 2.24e-03 1.07e-02 0.47300 -0.048400 0.471000 7.30e-01 7.78e-04
Regulation of signaling by CBL 13 1.28e-02 4.42e-02 0.47200 0.033600 0.470000 8.34e-01 3.33e-03
Transcriptional regulation by small RNAs 39 1.25e-05 1.07e-04 0.47100 0.406000 0.240000 1.19e-05 9.64e-03
Sema3A PAK dependent Axon repulsion 15 3.08e-03 1.37e-02 0.47000 -0.183000 0.433000 2.20e-01 3.68e-03
Negative regulation of NMDA receptor-mediated neuronal transmission 12 1.96e-02 5.91e-02 0.47000 -0.467000 -0.055400 5.11e-03 7.40e-01
PRC2 methylates histones and DNA 14 1.82e-02 5.60e-02 0.47000 0.258000 0.393000 9.44e-02 1.09e-02
tRNA processing in the nucleus 48 4.82e-07 7.92e-06 0.46900 0.445000 0.149000 1.00e-07 7.53e-02
HS-GAG degradation 16 2.34e-03 1.10e-02 0.46700 -0.435000 0.171000 2.59e-03 2.37e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 1.73e-02 5.43e-02 0.46400 0.149000 -0.439000 3.92e-01 1.16e-02
Glycogen metabolism 23 1.41e-03 7.21e-03 0.46400 -0.415000 -0.208000 5.81e-04 8.46e-02
Attenuation phase 20 4.26e-03 1.81e-02 0.46300 0.329000 0.326000 1.09e-02 1.16e-02
Platelet Aggregation (Plug Formation) 22 3.70e-04 2.24e-03 0.46200 -0.121000 0.446000 3.26e-01 2.98e-04
Prefoldin mediated transfer of substrate to CCT/TriC 22 1.45e-03 7.34e-03 0.46000 0.124000 0.443000 3.16e-01 3.22e-04
Effects of PIP2 hydrolysis 19 6.23e-03 2.50e-02 0.45800 -0.324000 -0.324000 1.44e-02 1.46e-02
Formation of the cornified envelope 10 2.69e-02 7.61e-02 0.45700 -0.427000 0.164000 1.95e-02 3.70e-01
Peroxisomal lipid metabolism 22 1.41e-03 7.19e-03 0.45600 -0.095500 -0.446000 4.39e-01 2.93e-04
Listeria monocytogenes entry into host cells 15 1.41e-02 4.72e-02 0.45600 0.162000 0.426000 2.78e-01 4.25e-03
HS-GAG biosynthesis 18 1.14e-03 5.98e-03 0.45500 -0.292000 0.349000 3.18e-02 1.04e-02
Protein localization 136 1.08e-18 7.39e-17 0.45300 -0.045800 -0.451000 3.58e-01 1.19e-19
NGF-stimulated transcription 32 3.21e-05 2.53e-04 0.44900 -0.050900 0.446000 6.19e-01 1.29e-05
Sema4D in semaphorin signaling 23 2.48e-04 1.62e-03 0.44800 -0.246000 0.375000 4.10e-02 1.88e-03
Glycogen storage diseases 11 5.25e-02 1.26e-01 0.44700 -0.407000 -0.185000 1.94e-02 2.89e-01
Unblocking of NMDA receptors, glutamate binding and activation 10 5.50e-02 1.31e-01 0.44600 -0.440000 -0.074100 1.60e-02 6.85e-01
N-Glycan antennae elongation 12 1.38e-02 4.64e-02 0.44400 -0.261000 0.360000 1.18e-01 3.09e-02
Prolactin receptor signaling 10 7.78e-02 1.66e-01 0.44400 -0.247000 -0.369000 1.77e-01 4.31e-02
MET promotes cell motility 25 1.42e-04 9.75e-04 0.44400 -0.247000 0.369000 3.25e-02 1.42e-03
HCMV Early Events 50 3.27e-06 3.45e-05 0.44300 0.363000 0.255000 9.30e-06 1.85e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 24 1.03e-03 5.45e-03 0.44300 0.067500 0.437000 5.67e-01 2.09e-04
PKA activation 15 1.32e-02 4.47e-02 0.44200 -0.439000 -0.058200 3.28e-03 6.96e-01
Negative regulation of MET activity 16 1.56e-02 5.09e-02 0.44000 0.182000 0.401000 2.09e-01 5.47e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 57 7.44e-07 1.10e-05 0.44000 0.353000 0.262000 4.05e-06 6.41e-04
Amplification of signal from the kinetochores 57 7.44e-07 1.10e-05 0.44000 0.353000 0.262000 4.05e-06 6.41e-04
mRNA 3'-end processing 49 2.16e-06 2.38e-05 0.43900 0.417000 0.139000 4.52e-07 9.37e-02
Late Phase of HIV Life Cycle 112 9.97e-13 4.55e-11 0.43900 0.359000 0.253000 5.75e-11 3.97e-06
ATF6 (ATF6-alpha) activates chaperone genes 10 6.66e-02 1.52e-01 0.43900 0.117000 0.423000 5.21e-01 2.06e-02
SUMOylation of chromatin organization proteins 46 1.28e-05 1.08e-04 0.43900 0.333000 0.286000 9.66e-05 8.03e-04
Peroxisomal protein import 49 2.33e-06 2.55e-05 0.43500 -0.117000 -0.419000 1.59e-01 4.06e-07
Infection with Mycobacterium tuberculosis 19 1.00e-02 3.62e-02 0.43400 0.255000 0.351000 5.49e-02 8.02e-03
Collagen biosynthesis and modifying enzymes 48 7.91e-08 1.55e-06 0.43300 -0.330000 0.282000 7.91e-05 7.48e-04
Resolution of Sister Chromatid Cohesion 66 1.13e-07 2.08e-06 0.43300 0.362000 0.237000 3.63e-07 8.69e-04
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 10 8.36e-02 1.72e-01 0.43300 0.198000 0.385000 2.78e-01 3.52e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 8.36e-02 1.72e-01 0.43300 0.198000 0.385000 2.78e-01 3.52e-02
TNFR1-induced proapoptotic signaling 11 2.38e-02 6.92e-02 0.43200 -0.322000 0.288000 6.44e-02 9.82e-02
CS/DS degradation 10 3.44e-02 9.26e-02 0.43100 -0.265000 0.340000 1.47e-01 6.24e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 9.27e-03 3.40e-02 0.43100 0.191000 0.386000 1.50e-01 3.59e-03
FCGR3A-mediated phagocytosis 47 1.34e-06 1.72e-05 0.43000 -0.012200 0.429000 8.86e-01 3.57e-07
Leishmania phagocytosis 47 1.34e-06 1.72e-05 0.43000 -0.012200 0.429000 8.86e-01 3.57e-07
Parasite infection 47 1.34e-06 1.72e-05 0.43000 -0.012200 0.429000 8.86e-01 3.57e-07
Synthesis of IP3 and IP4 in the cytosol 19 2.89e-03 1.32e-02 0.42900 -0.416000 0.104000 1.70e-03 4.34e-01
Beta-catenin phosphorylation cascade 15 2.96e-02 8.25e-02 0.42700 0.248000 0.347000 9.67e-02 1.98e-02
ABC transporters in lipid homeostasis 11 6.25e-02 1.45e-01 0.42500 -0.123000 -0.407000 4.80e-01 1.95e-02
HIV Life Cycle 122 6.45e-13 3.06e-11 0.42400 0.349000 0.240000 2.98e-11 4.84e-06
EML4 and NUDC in mitotic spindle formation 61 9.90e-07 1.41e-05 0.42200 0.326000 0.268000 1.10e-05 3.01e-04
Mucopolysaccharidoses 11 2.90e-02 8.12e-02 0.42200 -0.335000 0.255000 5.41e-02 1.43e-01
RNA Polymerase II Transcription Termination 57 6.40e-07 1.01e-05 0.42100 0.408000 0.105000 1.02e-07 1.73e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 8.38e-02 1.72e-01 0.42000 0.114000 0.404000 5.31e-01 2.68e-02
Assembly Of The HIV Virion 12 2.58e-02 7.36e-02 0.42000 -0.147000 0.394000 3.79e-01 1.82e-02
GAB1 signalosome 12 2.19e-02 6.51e-02 0.42000 -0.243000 0.342000 1.45e-01 4.00e-02
RHO GTPases Activate WASPs and WAVEs 31 4.07e-04 2.43e-03 0.42000 0.090300 0.410000 3.85e-01 7.88e-05
Formation of RNA Pol II elongation complex 50 9.50e-06 8.60e-05 0.41900 0.371000 0.195000 5.81e-06 1.73e-02
RNA Polymerase II Transcription Elongation 50 9.50e-06 8.60e-05 0.41900 0.371000 0.195000 5.81e-06 1.73e-02
Condensation of Prophase Chromosomes 11 7.79e-02 1.66e-01 0.41800 0.373000 0.190000 3.24e-02 2.75e-01
Elastic fibre formation 34 7.69e-05 5.67e-04 0.41800 -0.040700 0.416000 6.81e-01 2.76e-05
Regulation of actin dynamics for phagocytic cup formation 49 1.62e-06 1.97e-05 0.41600 -0.022700 0.415000 7.84e-01 4.98e-07
PI-3K cascade:FGFR2 10 5.47e-02 1.30e-01 0.41500 -0.108000 0.401000 5.56e-01 2.81e-02
SHC-mediated cascade:FGFR3 10 8.33e-02 1.72e-01 0.41500 0.081400 0.407000 6.56e-01 2.58e-02
Regulation of HSF1-mediated heat shock response 65 4.55e-07 7.58e-06 0.41500 0.361000 0.204000 4.99e-07 4.50e-03
Biotin transport and metabolism 10 7.34e-02 1.62e-01 0.41400 -0.020100 -0.414000 9.12e-01 2.34e-02
Cell-extracellular matrix interactions 16 6.99e-03 2.69e-02 0.41400 -0.258000 0.323000 7.37e-02 2.54e-02
Mitotic Telophase/Cytokinesis 10 9.08e-02 1.82e-01 0.41300 0.398000 0.111000 2.93e-02 5.45e-01
PI-3K cascade:FGFR3 10 8.29e-02 1.72e-01 0.41300 0.065300 0.408000 7.21e-01 2.57e-02
SHC-mediated cascade:FGFR2 10 5.98e-02 1.39e-01 0.41100 -0.091500 0.401000 6.16e-01 2.82e-02
BBSome-mediated cargo-targeting to cilium 18 1.30e-02 4.45e-02 0.41100 0.401000 0.088600 3.25e-03 5.15e-01
FGFR2 alternative splicing 22 5.85e-03 2.37e-02 0.41100 0.391000 0.125000 1.51e-03 3.09e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 2.20e-02 6.53e-02 0.41000 -0.167000 0.374000 2.98e-01 1.96e-02
RNA polymerase II transcribes snRNA genes 67 2.12e-07 3.73e-06 0.40900 0.386000 0.135000 4.77e-08 5.59e-02
Negative epigenetic regulation of rRNA expression 43 4.89e-05 3.75e-04 0.40900 0.388000 0.127000 1.06e-05 1.50e-01
Inwardly rectifying K+ channels 17 2.51e-02 7.19e-02 0.40800 -0.212000 -0.349000 1.31e-01 1.28e-02
Metabolism of porphyrins 18 1.67e-02 5.32e-02 0.40800 -0.143000 -0.382000 2.93e-01 5.06e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.55e-02 5.08e-02 0.40700 -0.216000 0.346000 1.63e-01 2.52e-02
PKA activation in glucagon signalling 14 3.65e-02 9.70e-02 0.40700 -0.397000 -0.090500 1.02e-02 5.58e-01
Chondroitin sulfate biosynthesis 14 1.78e-02 5.56e-02 0.40700 -0.155000 0.376000 3.14e-01 1.49e-02
Pre-NOTCH Processing in Golgi 14 2.23e-02 6.54e-02 0.40600 -0.398000 0.078400 9.92e-03 6.12e-01
Sema4D induced cell migration and growth-cone collapse 19 3.79e-03 1.65e-02 0.40500 -0.206000 0.349000 1.20e-01 8.49e-03
Synthesis of PIPs at the Golgi membrane 15 4.29e-02 1.09e-01 0.40400 0.326000 0.239000 2.88e-02 1.10e-01
ECM proteoglycans 37 1.78e-05 1.45e-04 0.40300 -0.270000 0.300000 4.56e-03 1.60e-03
p75NTR signals via NF-kB 13 3.82e-02 9.95e-02 0.40300 0.001700 0.403000 9.92e-01 1.19e-02
Interleukin-4 and Interleukin-13 signaling 64 1.92e-08 4.11e-07 0.40300 -0.130000 0.382000 7.24e-02 1.33e-07
p75NTR recruits signalling complexes 10 1.03e-01 1.98e-01 0.40300 0.111000 0.387000 5.42e-01 3.40e-02
Prolonged ERK activation events 12 8.17e-02 1.70e-01 0.40100 0.220000 0.336000 1.88e-01 4.40e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 3.14e-02 8.60e-02 0.40100 -0.079400 0.393000 6.20e-01 1.41e-02
Metabolism of cofactors 16 3.06e-02 8.40e-02 0.40100 -0.152000 -0.371000 2.94e-01 1.02e-02
Fatty acid metabolism 102 7.30e-10 2.00e-08 0.40100 -0.222000 -0.333000 1.08e-04 6.44e-09
mRNA Splicing - Minor Pathway 47 1.28e-05 1.08e-04 0.40000 0.398000 0.029900 2.33e-06 7.23e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 9.39e-02 1.86e-01 0.39800 0.151000 0.369000 3.85e-01 3.43e-02
PERK regulates gene expression 28 2.85e-03 1.31e-02 0.39700 0.355000 0.178000 1.14e-03 1.04e-01
FRS-mediated FGFR3 signaling 12 6.70e-02 1.53e-01 0.39700 0.085500 0.387000 6.08e-01 2.02e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 10 1.11e-01 2.11e-01 0.39600 0.109000 0.381000 5.49e-01 3.71e-02
Interleukin-37 signaling 16 2.32e-02 6.77e-02 0.39500 0.027200 0.394000 8.51e-01 6.38e-03
Pausing and recovery of Tat-mediated HIV elongation 25 7.07e-03 2.70e-02 0.39400 0.300000 0.256000 9.46e-03 2.70e-02
Tat-mediated HIV elongation arrest and recovery 25 7.07e-03 2.70e-02 0.39400 0.300000 0.256000 9.46e-03 2.70e-02
Frs2-mediated activation 10 1.21e-01 2.19e-01 0.39300 0.138000 0.368000 4.49e-01 4.38e-02
SUMOylation of DNA damage response and repair proteins 62 4.82e-06 4.68e-05 0.39200 0.318000 0.230000 1.51e-05 1.77e-03
Collagen formation 64 1.90e-08 4.11e-07 0.39200 -0.293000 0.260000 5.24e-05 3.28e-04
Platelet calcium homeostasis 18 1.61e-02 5.20e-02 0.39000 -0.389000 -0.030100 4.26e-03 8.25e-01
Neurexins and neuroligins 26 1.27e-03 6.57e-03 0.39000 -0.105000 0.376000 3.54e-01 9.23e-04
HIV elongation arrest and recovery 27 4.82e-03 2.02e-02 0.38900 0.334000 0.199000 2.64e-03 7.36e-02
Pausing and recovery of HIV elongation 27 4.82e-03 2.02e-02 0.38900 0.334000 0.199000 2.64e-03 7.36e-02
SUMOylation of transcription factors 14 5.66e-02 1.33e-01 0.38700 0.134000 0.363000 3.86e-01 1.86e-02
The NLRP3 inflammasome 10 8.21e-02 1.71e-01 0.38700 -0.089300 0.376000 6.25e-01 3.93e-02
FRS-mediated FGFR2 signaling 12 5.39e-02 1.29e-01 0.38700 -0.058600 0.382000 7.25e-01 2.19e-02
Gene Silencing by RNA 54 2.08e-05 1.69e-04 0.38600 0.352000 0.159000 7.67e-06 4.41e-02
Heparan sulfate/heparin (HS-GAG) metabolism 34 9.86e-05 7.07e-04 0.38600 -0.273000 0.274000 5.94e-03 5.81e-03
NoRC negatively regulates rRNA expression 40 2.68e-04 1.72e-03 0.38600 0.366000 0.120000 6.13e-05 1.88e-01
Antiviral mechanism by IFN-stimulated genes 64 5.97e-06 5.62e-05 0.38500 0.282000 0.262000 9.80e-05 2.93e-04
Keratinization 12 4.39e-02 1.10e-01 0.38400 -0.345000 0.170000 3.86e-02 3.09e-01
Activation of G protein gated Potassium channels 14 6.83e-02 1.54e-01 0.38400 -0.201000 -0.327000 1.94e-01 3.42e-02
G protein gated Potassium channels 14 6.83e-02 1.54e-01 0.38400 -0.201000 -0.327000 1.94e-01 3.42e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 14 6.83e-02 1.54e-01 0.38400 -0.201000 -0.327000 1.94e-01 3.42e-02
Nuclear Receptor transcription pathway 38 5.40e-04 3.14e-03 0.38300 -0.353000 -0.150000 1.70e-04 1.09e-01
Degradation of the extracellular matrix 58 2.07e-07 3.71e-06 0.38300 -0.301000 0.237000 7.56e-05 1.79e-03
Interleukin-6 signaling 10 7.20e-02 1.59e-01 0.38300 -0.202000 0.325000 2.68e-01 7.49e-02
AKT phosphorylates targets in the nucleus 10 1.12e-01 2.12e-01 0.38300 -0.381000 -0.039500 3.70e-02 8.29e-01
RNA Pol II CTD phosphorylation and interaction with CE 24 6.14e-03 2.47e-02 0.38300 0.376000 0.068300 1.42e-03 5.63e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 6.14e-03 2.47e-02 0.38300 0.376000 0.068300 1.42e-03 5.63e-01
CaM pathway 27 2.02e-03 9.85e-03 0.38200 -0.381000 0.021000 6.07e-04 8.50e-01
Calmodulin induced events 27 2.02e-03 9.85e-03 0.38200 -0.381000 0.021000 6.07e-04 8.50e-01
Erythropoietin activates RAS 11 9.17e-02 1.82e-01 0.38100 0.037000 0.379000 8.32e-01 2.93e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 33 2.17e-03 1.04e-02 0.38000 0.222000 0.308000 2.71e-02 2.18e-03
Metabolism of RNA 567 3.29e-49 4.05e-46 0.38000 0.370000 0.088300 2.72e-50 3.91e-04
Potassium Channels 34 1.57e-03 7.87e-03 0.38000 -0.334000 -0.181000 7.53e-04 6.80e-02
rRNA processing in the nucleus and cytosol 143 3.08e-13 1.52e-11 0.38000 0.367000 0.097600 4.03e-14 4.47e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 20 5.38e-03 2.19e-02 0.37900 -0.279000 0.256000 3.06e-02 4.74e-02
Nephrin family interactions 17 3.61e-02 9.63e-02 0.37900 0.137000 0.353000 3.30e-01 1.17e-02
Deposition of new CENPA-containing nucleosomes at the centromere 14 7.56e-02 1.65e-01 0.37800 0.308000 0.219000 4.58e-02 1.55e-01
Nucleosome assembly 14 7.56e-02 1.65e-01 0.37800 0.308000 0.219000 4.58e-02 1.55e-01
Signalling to RAS 16 1.69e-02 5.35e-02 0.37800 -0.328000 0.189000 2.34e-02 1.90e-01
mRNA Capping 26 4.88e-03 2.02e-02 0.37700 0.370000 0.075900 1.11e-03 5.03e-01
EPHA-mediated growth cone collapse 13 4.40e-02 1.10e-01 0.37700 -0.103000 0.363000 5.20e-01 2.36e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 4.76e-02 1.17e-01 0.37700 0.368000 0.081000 1.37e-02 5.87e-01
Signaling by MET 53 1.01e-05 8.93e-05 0.37600 0.007420 0.376000 9.26e-01 2.18e-06
Class I peroxisomal membrane protein import 20 1.07e-02 3.79e-02 0.37600 0.040200 -0.374000 7.56e-01 3.78e-03
Amino acid transport across the plasma membrane 20 6.08e-03 2.46e-02 0.37600 -0.303000 0.223000 1.91e-02 8.49e-02
Ephrin signaling 18 1.07e-02 3.79e-02 0.37600 -0.192000 0.323000 1.58e-01 1.78e-02
Misspliced GSK3beta mutants stabilize beta-catenin 14 7.76e-02 1.66e-01 0.37500 0.203000 0.316000 1.89e-01 4.10e-02
S33 mutants of beta-catenin aren't phosphorylated 14 7.76e-02 1.66e-01 0.37500 0.203000 0.316000 1.89e-01 4.10e-02
S37 mutants of beta-catenin aren't phosphorylated 14 7.76e-02 1.66e-01 0.37500 0.203000 0.316000 1.89e-01 4.10e-02
S45 mutants of beta-catenin aren't phosphorylated 14 7.76e-02 1.66e-01 0.37500 0.203000 0.316000 1.89e-01 4.10e-02
T41 mutants of beta-catenin aren't phosphorylated 14 7.76e-02 1.66e-01 0.37500 0.203000 0.316000 1.89e-01 4.10e-02
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 7.76e-02 1.66e-01 0.37500 0.203000 0.316000 1.89e-01 4.10e-02
NF-kB is activated and signals survival 10 8.82e-02 1.79e-01 0.37400 -0.142000 0.346000 4.38e-01 5.84e-02
Semaphorin interactions 54 1.55e-06 1.91e-05 0.37300 -0.186000 0.324000 1.81e-02 3.99e-05
PKA-mediated phosphorylation of CREB 17 2.76e-02 7.78e-02 0.37300 -0.372000 -0.019300 7.86e-03 8.90e-01
Signaling by FGFR2 IIIa TM 16 5.87e-02 1.37e-01 0.37100 0.305000 0.210000 3.46e-02 1.46e-01
Major pathway of rRNA processing in the nucleolus and cytosol 134 6.73e-12 2.77e-10 0.37000 0.358000 0.092700 8.79e-13 6.47e-02
B-WICH complex positively regulates rRNA expression 28 7.39e-03 2.80e-02 0.37000 0.226000 0.293000 3.83e-02 7.38e-03
Triglyceride metabolism 20 2.63e-02 7.48e-02 0.37000 -0.163000 -0.332000 2.07e-01 1.02e-02
p38MAPK events 12 7.03e-02 1.57e-01 0.36900 -0.366000 0.052200 2.84e-02 7.55e-01
Non-integrin membrane-ECM interactions 36 1.45e-04 9.90e-04 0.36800 -0.280000 0.239000 3.71e-03 1.31e-02
Deadenylation of mRNA 24 1.48e-02 4.86e-02 0.36600 0.317000 0.184000 7.24e-03 1.18e-01
ISG15 antiviral mechanism 59 4.49e-05 3.49e-04 0.36600 0.271000 0.246000 3.29e-04 1.11e-03
Extracellular matrix organization 194 6.78e-21 5.97e-19 0.36500 -0.253000 0.263000 1.41e-09 3.11e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 7.17e-02 1.59e-01 0.36500 -0.300000 0.208000 8.53e-02 2.33e-01
NCAM signaling for neurite out-growth 38 2.17e-04 1.43e-03 0.36300 -0.350000 0.095900 1.88e-04 3.07e-01
RHO GTPases Activate Formins 80 1.50e-06 1.87e-05 0.36300 0.222000 0.287000 6.01e-04 9.70e-06
Interleukin receptor SHC signaling 15 4.19e-02 1.07e-01 0.36200 -0.044200 0.359000 7.67e-01 1.60e-02
Chondroitin sulfate/dermatan sulfate metabolism 38 1.25e-04 8.72e-04 0.36100 -0.242000 0.268000 1.00e-02 4.27e-03
RHO GTPases activate PAKs 19 1.21e-02 4.24e-02 0.35900 -0.293000 0.207000 2.72e-02 1.18e-01
Zinc transporters 11 1.59e-01 2.70e-01 0.35900 0.304000 0.190000 8.12e-02 2.74e-01
Transcriptional regulation of pluripotent stem cells 11 8.92e-02 1.79e-01 0.35700 -0.120000 0.337000 4.92e-01 5.32e-02
PINK1-PRKN Mediated Mitophagy 17 2.33e-02 6.80e-02 0.35700 0.133000 -0.331000 3.42e-01 1.81e-02
Laminin interactions 20 1.29e-02 4.44e-02 0.35700 -0.339000 0.111000 8.67e-03 3.91e-01
Calnexin/calreticulin cycle 23 1.86e-02 5.70e-02 0.35600 0.124000 0.334000 3.02e-01 5.61e-03
AMER1 mutants destabilize the destruction complex 13 1.19e-01 2.18e-01 0.35500 0.189000 0.300000 2.38e-01 6.10e-02
APC truncation mutants have impaired AXIN binding 13 1.19e-01 2.18e-01 0.35500 0.189000 0.300000 2.38e-01 6.10e-02
AXIN missense mutants destabilize the destruction complex 13 1.19e-01 2.18e-01 0.35500 0.189000 0.300000 2.38e-01 6.10e-02
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 1.19e-01 2.18e-01 0.35500 0.189000 0.300000 2.38e-01 6.10e-02
Truncations of AMER1 destabilize the destruction complex 13 1.19e-01 2.18e-01 0.35500 0.189000 0.300000 2.38e-01 6.10e-02
truncated APC mutants destabilize the destruction complex 13 1.19e-01 2.18e-01 0.35500 0.189000 0.300000 2.38e-01 6.10e-02
Nuclear Envelope Breakdown 42 1.05e-03 5.51e-03 0.35500 0.303000 0.184000 6.93e-04 3.89e-02
Formation of HIV elongation complex in the absence of HIV Tat 38 1.50e-03 7.60e-03 0.35400 0.331000 0.127000 4.16e-04 1.77e-01
DAG and IP3 signaling 33 1.63e-03 8.13e-03 0.35400 -0.354000 0.005300 4.36e-04 9.58e-01
Regulation of TP53 Activity through Methylation 14 7.81e-02 1.66e-01 0.35400 0.349000 0.060700 2.39e-02 6.94e-01
Synthesis of PIPs at the early endosome membrane 16 7.08e-02 1.58e-01 0.35200 0.152000 0.318000 2.92e-01 2.78e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 10 1.92e-01 3.12e-01 0.35000 -0.141000 -0.321000 4.41e-01 7.90e-02
Translesion Synthesis by POLH 16 5.62e-02 1.33e-01 0.35000 0.347000 0.051700 1.64e-02 7.20e-01
Diseases associated with glycosaminoglycan metabolism 31 9.99e-04 5.32e-03 0.35000 -0.236000 0.259000 2.31e-02 1.27e-02
Epigenetic regulation of gene expression 79 4.38e-06 4.39e-05 0.35000 0.279000 0.212000 1.92e-05 1.17e-03
tRNA processing 98 1.94e-08 4.11e-07 0.34700 0.347000 0.021400 3.23e-09 7.14e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 21 3.83e-02 9.95e-02 0.34700 0.285000 0.198000 2.36e-02 1.17e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 3.30e-03 1.46e-02 0.34700 0.307000 0.162000 1.45e-03 9.31e-02
HIV Transcription Elongation 36 3.30e-03 1.46e-02 0.34700 0.307000 0.162000 1.45e-03 9.31e-02
Tat-mediated elongation of the HIV-1 transcript 36 3.30e-03 1.46e-02 0.34700 0.307000 0.162000 1.45e-03 9.31e-02
Fcgamma receptor (FCGR) dependent phagocytosis 67 1.81e-06 2.19e-05 0.34700 -0.065200 0.341000 3.57e-01 1.46e-06
NRAGE signals death through JNK 43 1.06e-04 7.50e-04 0.34600 -0.300000 0.172000 6.63e-04 5.15e-02
EPHB-mediated forward signaling 32 3.06e-03 1.37e-02 0.34600 0.019700 0.345000 8.47e-01 7.31e-04
Mitotic Spindle Checkpoint 74 9.54e-06 8.60e-05 0.34600 0.302000 0.169000 7.42e-06 1.22e-02
RHO GTPases Activate ROCKs 18 2.10e-02 6.28e-02 0.34500 -0.194000 0.286000 1.54e-01 3.60e-02
Synaptic adhesion-like molecules 12 1.03e-01 1.99e-01 0.34500 -0.344000 0.027400 3.92e-02 8.70e-01
Inflammasomes 12 7.49e-02 1.64e-01 0.34500 -0.219000 0.267000 1.90e-01 1.10e-01
Negative regulation of FGFR3 signaling 19 4.05e-02 1.04e-01 0.34400 0.079500 0.335000 5.49e-01 1.15e-02
TP53 Regulates Transcription of DNA Repair Genes 51 2.64e-04 1.71e-03 0.34400 0.322000 0.121000 6.89e-05 1.36e-01
Sulfur amino acid metabolism 21 4.15e-02 1.06e-01 0.34300 -0.196000 -0.281000 1.19e-01 2.58e-02
Diseases associated with the TLR signaling cascade 16 3.49e-02 9.36e-02 0.34300 -0.174000 0.295000 2.28e-01 4.11e-02
Diseases of Immune System 16 3.49e-02 9.36e-02 0.34300 -0.174000 0.295000 2.28e-01 4.11e-02
rRNA processing 154 4.37e-12 1.86e-10 0.34200 0.338000 0.051000 4.82e-13 2.76e-01
Caspase-mediated cleavage of cytoskeletal proteins 11 9.61e-02 1.88e-01 0.34200 -0.257000 0.225000 1.39e-01 1.96e-01
Translation 222 3.12e-20 2.56e-18 0.34200 0.144000 -0.310000 2.27e-04 2.14e-15
IKK complex recruitment mediated by RIP1 14 1.09e-01 2.08e-01 0.34200 0.130000 0.316000 4.00e-01 4.05e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 1.51e-01 2.61e-01 0.34100 0.337000 -0.050100 6.49e-02 7.84e-01
Caspase activation via extrinsic apoptotic signalling pathway 20 1.47e-02 4.85e-02 0.34100 -0.255000 0.226000 4.83e-02 8.05e-02
Protein-protein interactions at synapses 41 1.95e-04 1.31e-03 0.34000 -0.198000 0.276000 2.81e-02 2.24e-03
Retinoid metabolism and transport 19 1.87e-02 5.71e-02 0.34000 -0.263000 0.216000 4.76e-02 1.04e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 1.06e-02 3.79e-02 0.33800 0.335000 0.044500 2.60e-03 6.89e-01
Ca-dependent events 29 4.95e-03 2.05e-02 0.33700 -0.334000 0.041700 1.84e-03 6.98e-01
Regulation of IFNG signaling 13 1.38e-01 2.44e-01 0.33700 0.136000 0.308000 3.98e-01 5.44e-02
Signaling by FGFR3 fusions in cancer 10 2.34e-01 3.61e-01 0.33600 0.192000 0.275000 2.93e-01 1.32e-01
Constitutive Signaling by Overexpressed ERBB2 10 2.06e-01 3.29e-01 0.33600 0.092200 0.323000 6.14e-01 7.74e-02
Collagen chain trimerization 32 1.57e-03 7.87e-03 0.33500 -0.274000 0.193000 7.45e-03 5.91e-02
Stimuli-sensing channels 43 2.11e-03 1.02e-02 0.33400 -0.270000 -0.197000 2.23e-03 2.54e-02
Cholesterol biosynthesis 23 1.00e-02 3.61e-02 0.33400 -0.275000 0.188000 2.24e-02 1.18e-01
tRNA modification in the nucleus and cytosol 38 2.67e-03 1.24e-02 0.33200 0.322000 0.081500 5.97e-04 3.85e-01
Negative regulation of FGFR2 signaling 19 3.77e-02 9.92e-02 0.33200 -0.011600 0.332000 9.30e-01 1.23e-02
Assembly of collagen fibrils and other multimeric structures 43 1.96e-04 1.31e-03 0.33100 -0.260000 0.205000 3.16e-03 2.01e-02
KSRP (KHSRP) binds and destabilizes mRNA 16 8.72e-02 1.78e-01 0.33100 0.316000 0.100000 2.87e-02 4.89e-01
CLEC7A (Dectin-1) induces NFAT activation 10 1.93e-01 3.12e-01 0.33100 -0.330000 -0.027800 7.09e-02 8.79e-01
Activation of ATR in response to replication stress 28 1.60e-02 5.18e-02 0.33100 0.305000 0.127000 5.22e-03 2.43e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 11 1.12e-01 2.12e-01 0.33100 0.238000 -0.229000 1.71e-01 1.88e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 4.01e-02 1.04e-01 0.33000 -0.124000 0.306000 3.76e-01 2.91e-02
RHO GTPases activate CIT 17 3.84e-02 9.96e-02 0.32900 -0.151000 0.292000 2.80e-01 3.70e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 28 6.35e-03 2.53e-02 0.32900 -0.078600 0.319000 4.72e-01 3.48e-03
Downstream signaling of activated FGFR3 17 7.74e-02 1.66e-01 0.32800 0.092900 0.315000 5.07e-01 2.47e-02
Telomere Extension By Telomerase 19 4.95e-02 1.21e-01 0.32800 0.325000 0.045400 1.43e-02 7.32e-01
Processing of DNA double-strand break ends 50 8.17e-04 4.46e-03 0.32700 0.295000 0.142000 3.18e-04 8.19e-02
Interleukin-20 family signaling 12 1.17e-01 2.18e-01 0.32600 -0.315000 0.084300 5.90e-02 6.13e-01
Cellular response to heat stress 82 1.72e-05 1.41e-04 0.32500 0.231000 0.229000 3.15e-04 3.40e-04
Meiotic recombination 17 5.27e-02 1.27e-01 0.32500 0.320000 -0.056800 2.25e-02 6.85e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 25 2.98e-02 8.27e-02 0.32500 0.294000 0.138000 1.10e-02 2.33e-01
Chromosome Maintenance 68 6.35e-05 4.77e-04 0.32400 0.301000 0.122000 1.85e-05 8.25e-02
Basigin interactions 17 5.16e-02 1.26e-01 0.32400 -0.317000 0.068500 2.37e-02 6.25e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 56 5.94e-05 4.52e-04 0.32400 -0.315000 0.072200 4.54e-05 3.51e-01
G0 and Early G1 23 4.25e-02 1.08e-01 0.32300 0.285000 0.152000 1.82e-02 2.07e-01
Signaling by Leptin 10 1.86e-01 3.04e-01 0.32200 -0.320000 0.042600 8.02e-02 8.15e-01
Plasma lipoprotein remodeling 11 2.23e-01 3.48e-01 0.32200 -0.282000 -0.155000 1.05e-01 3.74e-01
Visual phototransduction 38 8.57e-04 4.63e-03 0.32000 -0.223000 0.229000 1.73e-02 1.47e-02
Mitotic Prophase 70 9.49e-05 6.89e-04 0.31900 0.273000 0.165000 7.92e-05 1.70e-02
Collagen degradation 20 2.63e-02 7.48e-02 0.31900 -0.275000 0.163000 3.35e-02 2.08e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 1.85e-01 3.02e-01 0.31900 -0.312000 0.066500 8.75e-02 7.16e-01
Activated NTRK2 signals through FRS2 and FRS3 10 2.25e-01 3.49e-01 0.31900 0.047400 0.316000 7.95e-01 8.41e-02
Translesion synthesis by POLK 15 8.90e-02 1.79e-01 0.31900 0.318000 -0.023400 3.30e-02 8.75e-01
Synthesis of bile acids and bile salts 18 8.07e-02 1.70e-01 0.31800 -0.099000 -0.302000 4.67e-01 2.66e-02
Formation of the Early Elongation Complex 30 1.58e-02 5.12e-02 0.31800 0.299000 0.108000 4.65e-03 3.05e-01
Formation of the HIV-1 Early Elongation Complex 30 1.58e-02 5.12e-02 0.31800 0.299000 0.108000 4.65e-03 3.05e-01
Leading Strand Synthesis 14 1.66e-01 2.78e-01 0.31800 0.227000 0.222000 1.41e-01 1.51e-01
Polymerase switching 14 1.66e-01 2.78e-01 0.31800 0.227000 0.222000 1.41e-01 1.51e-01
PI-3K cascade:FGFR4 10 1.79e-01 2.94e-01 0.31600 -0.105000 0.299000 5.65e-01 1.02e-01
Regulation of IFNA signaling 12 1.45e-01 2.54e-01 0.31600 -0.037800 0.314000 8.21e-01 6.00e-02
HDMs demethylate histones 19 8.75e-02 1.78e-01 0.31300 0.160000 0.269000 2.27e-01 4.21e-02
ATF6 (ATF6-alpha) activates chaperones 12 1.99e-01 3.19e-01 0.31300 0.106000 0.294000 5.23e-01 7.76e-02
Cell surface interactions at the vascular wall 72 3.68e-06 3.82e-05 0.31200 -0.264000 0.167000 1.11e-04 1.47e-02
Molecules associated with elastic fibres 25 2.73e-02 7.70e-02 0.31100 0.033300 0.309000 7.74e-01 7.43e-03
Downstream signaling of activated FGFR2 17 7.65e-02 1.66e-01 0.31100 -0.008850 0.311000 9.50e-01 2.64e-02
SHC-mediated cascade:FGFR4 10 1.93e-01 3.13e-01 0.31100 -0.089000 0.298000 6.26e-01 1.03e-01
Membrane binding and targetting of GAG proteins 10 2.12e-01 3.34e-01 0.31100 -0.032400 0.309000 8.59e-01 9.04e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 10 2.12e-01 3.34e-01 0.31100 -0.032400 0.309000 8.59e-01 9.04e-02
Telomere Maintenance 56 6.05e-04 3.46e-03 0.31100 0.293000 0.103000 1.51e-04 1.82e-01
ATF4 activates genes in response to endoplasmic reticulum stress 24 4.01e-02 1.04e-01 0.31100 0.296000 0.093600 1.20e-02 4.28e-01
Glutathione conjugation 21 7.40e-02 1.63e-01 0.31000 -0.253000 -0.180000 4.50e-02 1.53e-01
Nuclear Envelope (NE) Reassembly 59 6.86e-04 3.84e-03 0.31000 0.173000 0.257000 2.15e-02 6.60e-04
Activation of the pre-replicative complex 27 3.31e-02 8.98e-02 0.30900 0.273000 0.145000 1.40e-02 1.92e-01
Acyl chain remodelling of PS 10 2.96e-01 4.26e-01 0.30900 0.217000 0.220000 2.34e-01 2.28e-01
Caspase activation via Death Receptors in the presence of ligand 11 1.49e-01 2.58e-01 0.30900 -0.239000 0.196000 1.70e-01 2.61e-01
Transcriptional Regulation by E2F6 29 2.67e-02 7.58e-02 0.30900 0.268000 0.154000 1.26e-02 1.51e-01
Translesion synthesis by POLI 15 1.12e-01 2.12e-01 0.30900 0.309000 0.009320 3.84e-02 9.50e-01
Estrogen-dependent gene expression 75 1.17e-04 8.20e-04 0.30900 0.227000 0.210000 7.09e-04 1.72e-03
Downstream signaling of activated FGFR1 19 6.82e-02 1.54e-01 0.30900 0.035200 0.307000 7.91e-01 2.07e-02
Nucleotide salvage 18 6.74e-02 1.53e-01 0.30800 -0.307000 0.019500 2.40e-02 8.86e-01
RNA Polymerase I Promoter Escape 25 3.81e-02 9.95e-02 0.30800 0.292000 0.096700 1.15e-02 4.03e-01
Glycosaminoglycan metabolism 81 1.42e-06 1.79e-05 0.30600 -0.153000 0.265000 1.77e-02 3.76e-05
Diseases of carbohydrate metabolism 26 2.92e-02 8.15e-02 0.30600 -0.301000 -0.053000 7.85e-03 6.40e-01
Class B/2 (Secretin family receptors) 33 1.96e-02 5.91e-02 0.30600 -0.236000 -0.194000 1.91e-02 5.35e-02
RHO GTPases activate PKNs 29 1.28e-02 4.42e-02 0.30500 -0.042400 0.302000 6.93e-01 4.94e-03
Synthesis of PIPs at the late endosome membrane 10 3.03e-01 4.32e-01 0.30300 0.257000 0.159000 1.59e-01 3.83e-01
Association of TriC/CCT with target proteins during biosynthesis 36 1.52e-02 4.99e-02 0.30300 0.210000 0.217000 2.91e-02 2.41e-02
Sialic acid metabolism 23 4.21e-02 1.07e-01 0.30200 -0.302000 -0.021400 1.23e-02 8.59e-01
RNA Polymerase III Chain Elongation 17 7.81e-02 1.66e-01 0.30200 0.297000 -0.053800 3.38e-02 7.01e-01
Mitochondrial biogenesis 66 2.01e-04 1.34e-03 0.30200 -0.071200 -0.293000 3.18e-01 3.83e-05
FRS-mediated FGFR4 signaling 12 1.65e-01 2.78e-01 0.30200 -0.056500 0.296000 7.35e-01 7.54e-02
Signaling by high-kinase activity BRAF mutants 27 1.61e-02 5.20e-02 0.30000 -0.088200 0.287000 4.28e-01 9.94e-03
Extension of Telomeres 43 5.11e-03 2.09e-02 0.30000 0.281000 0.104000 1.43e-03 2.40e-01
Glucagon signaling in metabolic regulation 23 6.33e-02 1.46e-01 0.29900 -0.274000 -0.119000 2.30e-02 3.25e-01
Myogenesis 26 1.82e-02 5.61e-02 0.29900 -0.279000 0.107000 1.39e-02 3.47e-01
HCMV Infection 68 4.67e-04 2.76e-03 0.29700 0.239000 0.176000 6.59e-04 1.23e-02
Mitophagy 24 2.40e-02 6.93e-02 0.29700 0.134000 -0.265000 2.56e-01 2.49e-02
HIV Infection 187 8.19e-10 2.15e-08 0.29700 0.243000 0.170000 1.09e-08 6.69e-05
Signaling by PDGF 46 7.00e-04 3.87e-03 0.29600 -0.181000 0.234000 3.36e-02 6.19e-03
Activation of BAD and translocation to mitochondria 13 1.27e-01 2.27e-01 0.29500 -0.221000 0.196000 1.69e-01 2.21e-01
PI-3K cascade:FGFR1 10 2.47e-01 3.74e-01 0.29500 -0.033500 0.293000 8.54e-01 1.09e-01
RHO GTPase Effectors 173 7.60e-10 2.04e-08 0.29500 0.071600 0.286000 1.06e-01 1.03e-10
Detoxification of Reactive Oxygen Species 26 3.74e-02 9.84e-02 0.29500 -0.291000 -0.047900 1.04e-02 6.72e-01
Interleukin-6 family signaling 16 8.26e-02 1.72e-01 0.29400 -0.246000 0.162000 8.88e-02 2.62e-01
Chaperone Mediated Autophagy 14 1.37e-01 2.42e-01 0.29400 -0.055000 0.288000 7.22e-01 6.17e-02
SHC-mediated cascade:FGFR1 10 2.57e-01 3.84e-01 0.29300 -0.017400 0.293000 9.24e-01 1.09e-01
FRS-mediated FGFR1 signaling 12 2.07e-01 3.29e-01 0.29200 0.003190 0.292000 9.85e-01 8.00e-02
Keratan sulfate biosynthesis 17 7.17e-02 1.59e-01 0.29200 -0.198000 0.215000 1.59e-01 1.25e-01
Translesion synthesis by REV1 14 1.55e-01 2.66e-01 0.29100 0.291000 -0.014400 5.96e-02 9.26e-01
Assembly and cell surface presentation of NMDA receptors 13 1.55e-01 2.66e-01 0.29100 -0.280000 0.080500 8.08e-02 6.16e-01
Scavenging by Class A Receptors 13 1.36e-01 2.41e-01 0.29000 -0.196000 0.215000 2.22e-01 1.80e-01
Inhibition of DNA recombination at telomere 19 8.89e-02 1.79e-01 0.29000 0.290000 0.017100 2.89e-02 8.97e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 62 3.09e-04 1.93e-03 0.29000 -0.005260 0.290000 9.43e-01 8.01e-05
FCGR3A-mediated IL10 synthesis 25 3.23e-02 8.80e-02 0.28900 -0.284000 0.052000 1.39e-02 6.53e-01
Signaling by FGFR3 29 3.67e-02 9.73e-02 0.28900 0.099200 0.271000 3.56e-01 1.16e-02
Signaling by PDGFRA extracellular domain mutants 11 2.85e-01 4.13e-01 0.28800 0.098600 0.271000 5.72e-01 1.20e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 11 2.85e-01 4.13e-01 0.28800 0.098600 0.271000 5.72e-01 1.20e-01
Metabolism of fat-soluble vitamins 22 3.71e-02 9.80e-02 0.28800 -0.235000 0.167000 5.64e-02 1.76e-01
Processing of Intronless Pre-mRNAs 17 1.66e-01 2.78e-01 0.28800 0.223000 0.182000 1.12e-01 1.94e-01
VEGFA-VEGFR2 Pathway 77 1.43e-05 1.19e-04 0.28700 -0.128000 0.257000 5.26e-02 9.79e-05
Signaling by SCF-KIT 32 1.38e-02 4.64e-02 0.28700 -0.044100 0.284000 6.66e-01 5.54e-03
Aquaporin-mediated transport 29 4.79e-02 1.18e-01 0.28700 -0.216000 -0.189000 4.46e-02 7.81e-02
Purine ribonucleoside monophosphate biosynthesis 12 2.09e-01 3.32e-01 0.28600 0.024000 -0.285000 8.86e-01 8.74e-02
EPH-Ephrin signaling 75 3.13e-05 2.49e-04 0.28600 -0.083500 0.274000 2.12e-01 4.32e-05
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 28 5.32e-02 1.28e-01 0.28600 0.173000 0.228000 1.13e-01 3.72e-02
TP53 Regulates Transcription of Cell Cycle Genes 43 6.77e-03 2.63e-02 0.28600 0.063300 0.278000 4.73e-01 1.60e-03
Signaling by FGFR2 52 4.64e-03 1.96e-02 0.28500 0.200000 0.203000 1.26e-02 1.13e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 22 4.73e-02 1.17e-01 0.28500 -0.089800 0.270000 4.66e-01 2.82e-02
Activation of AMPK downstream of NMDARs 10 3.04e-01 4.32e-01 0.28400 -0.282000 -0.039000 1.23e-01 8.31e-01
Polymerase switching on the C-strand of the telomere 22 9.56e-02 1.88e-01 0.28400 0.252000 0.132000 4.11e-02 2.83e-01
Signaling by FGFR 60 2.17e-03 1.04e-02 0.28400 0.186000 0.214000 1.29e-02 4.14e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17 1.75e-01 2.90e-01 0.28200 0.229000 0.166000 1.03e-01 2.37e-01
Golgi Associated Vesicle Biogenesis 49 6.98e-03 2.69e-02 0.28200 0.210000 0.189000 1.13e-02 2.20e-02
Signaling by PDGFR in disease 17 1.56e-01 2.67e-01 0.28200 0.092700 0.266000 5.08e-01 5.74e-02
RHO GTPases activate KTN1 10 3.41e-01 4.68e-01 0.28200 0.107000 0.261000 5.60e-01 1.53e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 19 1.44e-01 2.53e-01 0.28200 0.171000 0.224000 1.97e-01 9.08e-02
MECP2 regulates neuronal receptors and channels 10 3.58e-01 4.84e-01 0.28100 0.154000 0.236000 4.01e-01 1.97e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 1.66e-01 2.79e-01 0.28100 0.112000 -0.258000 4.84e-01 1.08e-01
Signaling by Hippo 18 1.47e-01 2.57e-01 0.28000 0.106000 0.259000 4.35e-01 5.69e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 2.11e-01 3.34e-01 0.28000 0.008550 0.280000 9.57e-01 8.09e-02
SUMOylation of transcription cofactors 38 2.21e-02 6.53e-02 0.27900 0.228000 0.161000 1.50e-02 8.63e-02
Downstream signal transduction 27 2.22e-02 6.54e-02 0.27900 -0.176000 0.217000 1.14e-01 5.14e-02
IRE1alpha activates chaperones 47 3.88e-03 1.68e-02 0.27900 0.012300 0.279000 8.84e-01 9.59e-04
Processing of Capped Intronless Pre-mRNA 25 6.91e-02 1.55e-01 0.27900 0.264000 0.090600 2.26e-02 4.33e-01
RNA Polymerase III Transcription Initiation 34 2.30e-02 6.74e-02 0.27800 0.272000 0.059000 6.07e-03 5.52e-01
Signaling by RAF1 mutants 32 1.12e-02 3.96e-02 0.27800 -0.176000 0.216000 8.58e-02 3.47e-02
Negative regulation of FGFR4 signaling 19 1.01e-01 1.95e-01 0.27800 -0.010300 0.278000 9.38e-01 3.62e-02
Platelet sensitization by LDL 13 2.63e-01 3.90e-01 0.27700 0.118000 0.251000 4.61e-01 1.17e-01
Negative regulation of the PI3K/AKT network 69 3.31e-04 2.05e-03 0.27700 0.014800 0.277000 8.32e-01 7.12e-05
Diseases associated with O-glycosylation of proteins 33 1.02e-02 3.65e-02 0.27700 -0.187000 0.204000 6.34e-02 4.26e-02
Pre-NOTCH Transcription and Translation 31 3.03e-02 8.33e-02 0.27600 0.034000 0.274000 7.43e-01 8.26e-03
Negative regulation of FGFR1 signaling 19 1.15e-01 2.15e-01 0.27600 0.027500 0.275000 8.36e-01 3.81e-02
G-protein mediated events 40 6.38e-03 2.53e-02 0.27600 -0.268000 0.062800 3.35e-03 4.92e-01
Mitotic Prometaphase 137 1.32e-06 1.72e-05 0.27500 0.242000 0.132000 1.09e-06 7.97e-03
Regulation of TP53 Activity through Phosphorylation 74 5.93e-04 3.40e-03 0.27500 0.248000 0.121000 2.37e-04 7.31e-02
HATs acetylate histones 72 9.46e-04 5.09e-03 0.27400 0.229000 0.151000 8.12e-04 2.69e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 25 6.57e-02 1.51e-01 0.27300 0.270000 0.045100 1.96e-02 6.97e-01
SUMOylation 137 2.47e-06 2.68e-05 0.27300 0.203000 0.184000 4.46e-05 2.17e-04
G alpha (12/13) signalling events 54 7.44e-04 4.08e-03 0.27300 -0.232000 0.145000 3.25e-03 6.61e-02
RAF-independent MAPK1/3 activation 21 5.98e-02 1.39e-01 0.27300 -0.157000 0.223000 2.13e-01 7.70e-02
Constitutive Signaling by Aberrant PI3K in Cancer 38 6.93e-03 2.69e-02 0.27200 -0.122000 0.244000 1.93e-01 9.42e-03
Nonhomologous End-Joining (NHEJ) 30 3.60e-02 9.63e-02 0.27200 0.271000 0.025000 1.02e-02 8.13e-01
Positive epigenetic regulation of rRNA expression 41 1.99e-02 5.98e-02 0.27100 0.144000 0.230000 1.11e-01 1.09e-02
Amyloid fiber formation 29 2.08e-02 6.23e-02 0.27100 -0.185000 0.199000 8.54e-02 6.45e-02
FGFR2 mutant receptor activation 18 1.84e-01 3.01e-01 0.27100 0.165000 0.215000 2.25e-01 1.15e-01
Interleukin-15 signaling 11 2.45e-01 3.73e-01 0.27000 -0.247000 0.109000 1.56e-01 5.30e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 31 4.77e-02 1.18e-01 0.27000 0.108000 0.248000 2.99e-01 1.71e-02
Integrin cell surface interactions 45 2.89e-03 1.32e-02 0.27000 -0.232000 0.139000 7.26e-03 1.08e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 40 2.43e-02 6.99e-02 0.27000 0.169000 0.210000 6.43e-02 2.16e-02
SHC1 events in ERBB2 signaling 15 1.39e-01 2.45e-01 0.27000 -0.163000 0.215000 2.75e-01 1.50e-01
O-linked glycosylation of mucins 21 6.60e-02 1.51e-01 0.26900 -0.140000 0.230000 2.66e-01 6.88e-02
DNA Damage/Telomere Stress Induced Senescence 26 8.78e-02 1.79e-01 0.26900 0.225000 0.147000 4.72e-02 1.94e-01
Signaling by FGFR1 34 3.43e-02 9.25e-02 0.26900 0.089000 0.254000 3.70e-01 1.05e-02
Keratan sulfate/keratin metabolism 22 5.64e-02 1.33e-01 0.26900 -0.169000 0.209000 1.70e-01 9.06e-02
Unfolded Protein Response (UPR) 82 4.53e-04 2.70e-03 0.26800 0.127000 0.236000 4.74e-02 2.30e-04
Notch-HLH transcription pathway 24 4.45e-02 1.11e-01 0.26700 -0.206000 0.171000 8.10e-02 1.48e-01
Signaling by FGFR3 in disease 14 2.36e-01 3.63e-01 0.26700 0.049600 0.262000 7.48e-01 8.91e-02
Signaling by FGFR3 point mutants in cancer 14 2.36e-01 3.63e-01 0.26700 0.049600 0.262000 7.48e-01 8.91e-02
Formation of TC-NER Pre-Incision Complex 48 4.87e-03 2.02e-02 0.26700 0.267000 -0.006600 1.39e-03 9.37e-01
FCERI mediated Ca+2 mobilization 18 1.00e-01 1.95e-01 0.26700 -0.223000 0.146000 1.01e-01 2.84e-01
ER Quality Control Compartment (ERQC) 18 1.77e-01 2.92e-01 0.26700 0.101000 0.247000 4.58e-01 6.99e-02
Vasopressin regulates renal water homeostasis via Aquaporins 27 8.59e-02 1.76e-01 0.26700 -0.209000 -0.166000 6.04e-02 1.36e-01
Transcriptional regulation of granulopoiesis 23 7.82e-02 1.66e-01 0.26600 -0.007540 0.266000 9.50e-01 2.71e-02
Metabolism of folate and pterines 13 2.51e-01 3.79e-01 0.26600 -0.265000 -0.021000 9.82e-02 8.96e-01
RIP-mediated NFkB activation via ZBP1 14 2.53e-01 3.80e-01 0.26500 0.076300 0.254000 6.21e-01 1.00e-01
activated TAK1 mediates p38 MAPK activation 17 1.15e-01 2.15e-01 0.26500 -0.171000 0.202000 2.23e-01 1.48e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 8.68e-03 3.22e-02 0.26500 -0.134000 0.228000 1.53e-01 1.49e-02
PLC beta mediated events 39 1.13e-02 3.96e-02 0.26500 -0.260000 0.048400 4.95e-03 6.01e-01
Signaling by Non-Receptor Tyrosine Kinases 42 7.88e-03 2.95e-02 0.26500 -0.050700 0.260000 5.70e-01 3.60e-03
Signaling by PTK6 42 7.88e-03 2.95e-02 0.26500 -0.050700 0.260000 5.70e-01 3.60e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 2.96e-01 4.26e-01 0.26500 -0.245000 0.099800 1.80e-01 5.85e-01
SUMOylation of intracellular receptors 23 1.12e-01 2.12e-01 0.26400 -0.247000 -0.091700 4.02e-02 4.47e-01
Methylation 10 3.66e-01 4.91e-01 0.26400 -0.048600 -0.259000 7.90e-01 1.56e-01
GABA receptor activation 27 8.81e-02 1.79e-01 0.26300 -0.222000 -0.141000 4.57e-02 2.05e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 1.02e-01 1.98e-01 0.26300 -0.096200 0.245000 4.68e-01 6.47e-02
Telomere C-strand synthesis initiation 11 2.93e-01 4.23e-01 0.26300 0.261000 -0.032600 1.34e-01 8.51e-01
Recognition of DNA damage by PCNA-containing replication complex 28 6.75e-02 1.53e-01 0.26300 0.252000 0.075700 2.12e-02 4.88e-01
Presynaptic phase of homologous DNA pairing and strand exchange 29 5.17e-02 1.26e-01 0.26300 0.261000 0.029800 1.51e-02 7.81e-01
Other interleukin signaling 13 2.03e-01 3.25e-01 0.26200 -0.132000 0.226000 4.10e-01 1.58e-01
Cell recruitment (pro-inflammatory response) 12 2.70e-01 3.96e-01 0.26200 -0.020900 0.261000 9.00e-01 1.17e-01
Purinergic signaling in leishmaniasis infection 12 2.70e-01 3.96e-01 0.26200 -0.020900 0.261000 9.00e-01 1.17e-01
Bile acid and bile salt metabolism 20 1.65e-01 2.78e-01 0.26100 -0.116000 -0.233000 3.69e-01 7.08e-02
Meiosis 38 1.87e-02 5.71e-02 0.26100 0.261000 0.000451 5.47e-03 9.96e-01
G2/M DNA damage checkpoint 49 1.39e-02 4.67e-02 0.26100 0.212000 0.151000 1.02e-02 6.72e-02
Signalling to ERKs 29 3.81e-02 9.95e-02 0.26000 -0.059000 0.253000 5.82e-01 1.83e-02
Metabolism of water-soluble vitamins and cofactors 89 1.28e-04 8.87e-04 0.26000 -0.021800 -0.259000 7.23e-01 2.49e-05
DARPP-32 events 21 1.63e-01 2.77e-01 0.26000 -0.202000 -0.163000 1.09e-01 1.96e-01
Signaling by Retinoic Acid 29 8.34e-02 1.72e-01 0.26000 -0.177000 -0.190000 1.00e-01 7.64e-02
SUMO E3 ligases SUMOylate target proteins 131 1.51e-05 1.25e-04 0.25900 0.193000 0.174000 1.48e-04 6.27e-04
Neurotransmitter release cycle 22 1.04e-01 2.00e-01 0.25900 0.005280 0.259000 9.66e-01 3.57e-02
Pentose phosphate pathway 12 3.59e-01 4.84e-01 0.25900 0.167000 0.197000 3.16e-01 2.37e-01
Separation of Sister Chromatids 125 1.25e-05 1.07e-04 0.25800 0.242000 0.091500 3.23e-06 7.80e-02
Regulation of localization of FOXO transcription factors 11 2.68e-01 3.95e-01 0.25800 -0.140000 0.217000 4.23e-01 2.12e-01
HCMV Late Events 43 2.42e-02 6.98e-02 0.25800 0.220000 0.134000 1.24e-02 1.29e-01
Sphingolipid de novo biosynthesis 32 4.40e-02 1.10e-01 0.25800 0.036100 0.255000 7.24e-01 1.25e-02
Signaling by VEGF 83 6.00e-05 4.54e-04 0.25800 -0.120000 0.228000 5.87e-02 3.37e-04
Cell-Cell communication 72 1.82e-04 1.23e-03 0.25800 -0.154000 0.206000 2.37e-02 2.49e-03
Cell Cycle Checkpoints 191 8.95e-08 1.72e-06 0.25800 0.219000 0.136000 2.07e-07 1.27e-03
Activation of GABAB receptors 25 1.19e-01 2.18e-01 0.25700 -0.213000 -0.143000 6.54e-02 2.15e-01
GABA B receptor activation 25 1.19e-01 2.18e-01 0.25700 -0.213000 -0.143000 6.54e-02 2.15e-01
Spry regulation of FGF signaling 14 2.53e-01 3.80e-01 0.25600 0.024900 0.255000 8.72e-01 9.85e-02
Regulation of TP53 Activity 134 9.70e-06 8.67e-05 0.25600 0.229000 0.115000 5.16e-06 2.14e-02
TNFR1-induced NFkappaB signaling pathway 21 9.15e-02 1.82e-01 0.25500 -0.233000 0.105000 6.51e-02 4.06e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 15 2.31e-01 3.58e-01 0.25500 0.254000 0.019100 8.85e-02 8.98e-01
XBP1(S) activates chaperone genes 45 1.09e-02 3.85e-02 0.25500 -0.003590 0.255000 9.67e-01 3.16e-03
Homologous DNA Pairing and Strand Exchange 30 5.51e-02 1.31e-01 0.25500 0.253000 0.024700 1.64e-02 8.15e-01
Mismatch Repair 14 1.92e-01 3.12e-01 0.25400 0.169000 -0.190000 2.74e-01 2.18e-01
TICAM1, RIP1-mediated IKK complex recruitment 14 3.00e-01 4.30e-01 0.25400 0.112000 0.229000 4.70e-01 1.39e-01
Deadenylation-dependent mRNA decay 53 7.71e-03 2.91e-02 0.25400 0.248000 0.055100 1.83e-03 4.88e-01
IL-6-type cytokine receptor ligand interactions 10 3.59e-01 4.84e-01 0.25400 -0.253000 0.020900 1.67e-01 9.09e-01
O-linked glycosylation 51 2.65e-03 1.24e-02 0.25300 -0.163000 0.195000 4.49e-02 1.64e-02
RNA Polymerase I Transcription Termination 25 1.01e-01 1.95e-01 0.25300 0.248000 0.052600 3.22e-02 6.49e-01
Signaling by NTRK1 (TRKA) 97 2.60e-05 2.09e-04 0.25300 -0.080800 0.240000 1.70e-01 4.64e-05
DAP12 interactions 15 2.40e-01 3.67e-01 0.25300 0.026200 0.251000 8.60e-01 9.18e-02
DAP12 signaling 15 2.40e-01 3.67e-01 0.25300 0.026200 0.251000 8.60e-01 9.18e-02
Signaling by NTRKs 113 4.16e-06 4.20e-05 0.25300 -0.091600 0.236000 9.34e-02 1.60e-05
Telomere C-strand (Lagging Strand) Synthesis 30 7.29e-02 1.61e-01 0.25300 0.237000 0.086900 2.46e-02 4.11e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 20 1.97e-01 3.17e-01 0.25200 -0.168000 -0.188000 1.93e-01 1.46e-01
Nuclear Events (kinase and transcription factor activation) 54 2.30e-03 1.09e-02 0.25200 -0.119000 0.223000 1.31e-01 4.72e-03
SLC transporter disorders 51 1.32e-02 4.47e-02 0.25200 0.103000 0.230000 2.03e-01 4.58e-03
Activation of the AP-1 family of transcription factors 10 3.74e-01 4.95e-01 0.25100 -0.007420 0.251000 9.68e-01 1.70e-01
Downstream signaling of activated FGFR4 17 1.88e-01 3.07e-01 0.25100 -0.007380 0.251000 9.58e-01 7.37e-02
Signaling by Rho GTPases 269 7.98e-12 3.17e-10 0.25100 0.000260 0.251000 9.94e-01 1.96e-12
trans-Golgi Network Vesicle Budding 63 6.55e-03 2.58e-02 0.25000 0.157000 0.195000 3.10e-02 7.60e-03
Phase I - Functionalization of compounds 39 3.86e-02 1.00e-01 0.25000 -0.226000 -0.106000 1.45e-02 2.50e-01
Dual incision in TC-NER 60 3.54e-03 1.55e-02 0.25000 0.249000 0.015500 8.46e-04 8.36e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 26 9.49e-02 1.87e-01 0.24900 0.246000 0.040100 3.00e-02 7.24e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 16 2.51e-01 3.78e-01 0.24900 0.239000 0.070700 9.86e-02 6.24e-01
Intrinsic Pathway for Apoptosis 42 1.07e-02 3.79e-02 0.24800 -0.108000 0.223000 2.26e-01 1.23e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF 36 1.80e-02 5.57e-02 0.24800 -0.167000 0.184000 8.40e-02 5.68e-02
Signaling by RAS mutants 36 1.80e-02 5.57e-02 0.24800 -0.167000 0.184000 8.40e-02 5.68e-02
Signaling by moderate kinase activity BRAF mutants 36 1.80e-02 5.57e-02 0.24800 -0.167000 0.184000 8.40e-02 5.68e-02
Signaling downstream of RAS mutants 36 1.80e-02 5.57e-02 0.24800 -0.167000 0.184000 8.40e-02 5.68e-02
Ovarian tumor domain proteases 31 7.29e-02 1.61e-01 0.24800 0.080000 0.234000 4.41e-01 2.40e-02
Formation of the beta-catenin:TCF transactivating complex 28 1.12e-01 2.12e-01 0.24800 0.158000 0.190000 1.47e-01 8.15e-02
Unwinding of DNA 10 3.70e-01 4.93e-01 0.24700 -0.035100 0.245000 8.47e-01 1.80e-01
Activation of gene expression by SREBF (SREBP) 40 1.30e-02 4.44e-02 0.24700 -0.215000 0.122000 1.87e-02 1.82e-01
Metal ion SLC transporters 17 2.46e-01 3.74e-01 0.24700 0.096100 0.228000 4.93e-01 1.04e-01
Interferon Signaling 120 9.18e-05 6.70e-04 0.24600 0.140000 0.203000 8.42e-03 1.31e-04
PIWI-interacting RNA (piRNA) biogenesis 13 2.99e-01 4.30e-01 0.24600 0.246000 0.005300 1.25e-01 9.74e-01
SLC-mediated transmembrane transport 120 4.81e-06 4.68e-05 0.24600 -0.234000 0.074100 9.69e-06 1.62e-01
Adenylate cyclase inhibitory pathway 11 3.16e-01 4.45e-01 0.24600 -0.228000 0.090700 1.90e-01 6.03e-01
Netrin-1 signaling 38 1.66e-02 5.29e-02 0.24500 -0.206000 0.133000 2.78e-02 1.57e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 3.85e-01 5.06e-01 0.24500 0.220000 0.108000 1.88e-01 5.17e-01
Mitotic Anaphase 171 2.16e-06 2.38e-05 0.24500 0.203000 0.136000 4.97e-06 2.23e-03
Mitotic Metaphase and Anaphase 171 2.16e-06 2.38e-05 0.24500 0.203000 0.136000 4.97e-06 2.23e-03
Regulation of TNFR1 signaling 26 8.17e-02 1.70e-01 0.24400 -0.243000 0.030100 3.23e-02 7.90e-01
DCC mediated attractive signaling 13 2.45e-01 3.73e-01 0.24400 -0.157000 0.187000 3.28e-01 2.43e-01
E2F mediated regulation of DNA replication 19 1.93e-01 3.12e-01 0.24300 0.240000 0.035400 6.97e-02 7.89e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 1.59e-01 2.70e-01 0.24300 0.206000 0.129000 8.08e-02 2.76e-01
Ion transport by P-type ATPases 34 5.14e-02 1.26e-01 0.24200 -0.241000 -0.026400 1.51e-02 7.90e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 4.71e-01 5.70e-01 0.24200 -0.197000 -0.140000 2.80e-01 4.44e-01
alpha-linolenic acid (ALA) metabolism 10 4.71e-01 5.70e-01 0.24200 -0.197000 -0.140000 2.80e-01 4.44e-01
Dopamine Neurotransmitter Release Cycle 11 3.62e-01 4.88e-01 0.24200 -0.015100 0.241000 9.31e-01 1.66e-01
Host Interactions of HIV factors 102 5.44e-04 3.15e-03 0.24100 0.178000 0.163000 1.91e-03 4.59e-03
Meiotic synapsis 22 1.75e-01 2.90e-01 0.24100 0.225000 0.087200 6.79e-02 4.79e-01
Hyaluronan metabolism 11 3.37e-01 4.64e-01 0.24100 -0.072400 0.230000 6.78e-01 1.87e-01
ERK/MAPK targets 22 1.71e-01 2.87e-01 0.24100 -0.229000 -0.076700 6.37e-02 5.34e-01
Cell death signalling via NRAGE, NRIF and NADE 57 2.65e-03 1.24e-02 0.24100 -0.199000 0.135000 9.38e-03 7.73e-02
Nucleobase biosynthesis 15 2.45e-01 3.73e-01 0.24100 0.031700 -0.239000 8.32e-01 1.10e-01
eNOS activation 10 3.51e-01 4.77e-01 0.24000 -0.183000 0.156000 3.17e-01 3.94e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 59 6.59e-03 2.59e-02 0.24000 0.238000 0.026100 1.57e-03 7.29e-01
HSF1-dependent transactivation 30 8.04e-02 1.70e-01 0.24000 0.035400 0.237000 7.37e-01 2.48e-02
Adherens junctions interactions 11 3.31e-01 4.58e-01 0.23800 -0.213000 0.107000 2.21e-01 5.41e-01
G alpha (i) signalling events 127 5.21e-06 4.98e-05 0.23800 -0.228000 0.071200 1.01e-05 1.67e-01
Glucagon-type ligand receptors 11 4.32e-01 5.44e-01 0.23800 -0.096200 -0.218000 5.81e-01 2.11e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 3.69e-01 4.93e-01 0.23700 0.031400 0.235000 8.50e-01 1.58e-01
Vitamin B5 (pantothenate) metabolism 15 2.21e-01 3.47e-01 0.23700 0.120000 -0.205000 4.21e-01 1.70e-01
Glycerophospholipid biosynthesis 82 2.71e-03 1.25e-02 0.23700 -0.136000 -0.194000 3.37e-02 2.40e-03
Signaling by FGFR4 29 9.41e-02 1.86e-01 0.23700 0.040300 0.233000 7.07e-01 2.97e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 76 4.22e-03 1.79e-02 0.23700 0.195000 0.135000 3.41e-03 4.23e-02
Uptake and function of anthrax toxins 11 3.47e-01 4.74e-01 0.23700 -0.224000 0.077500 1.99e-01 6.56e-01
Regulation of RUNX1 Expression and Activity 17 2.67e-01 3.95e-01 0.23500 0.063400 0.226000 6.51e-01 1.06e-01
G alpha (z) signalling events 29 9.33e-02 1.85e-01 0.23400 -0.233000 -0.020300 3.01e-02 8.50e-01
RET signaling 28 6.36e-02 1.47e-01 0.23300 -0.138000 0.188000 2.07e-01 8.47e-02
Transcription of E2F targets under negative control by DREAM complex 17 2.58e-01 3.84e-01 0.23300 0.231000 0.034700 9.99e-02 8.04e-01
mRNA decay by 3' to 5' exoribonuclease 15 2.95e-01 4.25e-01 0.23300 0.232000 0.020100 1.20e-01 8.93e-01
Activation of SMO 12 3.10e-01 4.38e-01 0.23300 -0.189000 0.135000 2.57e-01 4.17e-01
Lagging Strand Synthesis 20 2.24e-01 3.48e-01 0.23300 0.221000 0.072300 8.72e-02 5.76e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 1.48e-01 2.57e-01 0.23200 0.056500 0.225000 6.25e-01 5.12e-02
Translation of structural proteins 25 8.87e-02 1.79e-01 0.23200 -0.194000 0.128000 9.41e-02 2.67e-01
CTLA4 inhibitory signaling 17 2.29e-01 3.55e-01 0.23200 -0.028100 0.230000 8.41e-01 1.00e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 3.51e-01 4.77e-01 0.23200 0.068200 0.222000 6.59e-01 1.51e-01
Ras activation upon Ca2+ influx through NMDA receptor 13 3.95e-01 5.14e-01 0.23100 -0.209000 -0.098600 1.92e-01 5.39e-01
E3 ubiquitin ligases ubiquitinate target proteins 39 6.69e-02 1.53e-01 0.23100 0.198000 0.119000 3.26e-02 2.00e-01
Regulation of TP53 Activity through Acetylation 28 1.50e-01 2.60e-01 0.23100 0.162000 0.165000 1.39e-01 1.32e-01
Cell junction organization 46 1.32e-02 4.47e-02 0.23100 -0.203000 0.109000 1.71e-02 2.02e-01
NOD1/2 Signaling Pathway 27 8.06e-02 1.70e-01 0.23100 -0.097900 0.209000 3.79e-01 6.07e-02
Binding and Uptake of Ligands by Scavenger Receptors 23 1.11e-01 2.11e-01 0.22900 -0.152000 0.171000 2.06e-01 1.55e-01
Nicotinate metabolism 20 2.57e-01 3.84e-01 0.22900 -0.128000 -0.190000 3.22e-01 1.41e-01
Rho GTPase cycle 104 6.75e-05 5.04e-04 0.22900 -0.107000 0.203000 6.03e-02 3.65e-04
O-glycosylation of TSR domain-containing proteins 25 9.41e-02 1.86e-01 0.22800 -0.144000 0.177000 2.12e-01 1.26e-01
Signaling by FGFR2 in disease 28 1.51e-01 2.61e-01 0.22800 0.123000 0.192000 2.60e-01 7.85e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 31 9.17e-02 1.82e-01 0.22800 0.026200 0.227000 8.01e-01 2.91e-02
EPH-ephrin mediated repulsion of cells 37 3.23e-02 8.80e-02 0.22700 -0.125000 0.190000 1.88e-01 4.58e-02
PI3K/AKT Signaling in Cancer 65 2.42e-03 1.13e-02 0.22700 -0.134000 0.184000 6.31e-02 1.06e-02
G beta:gamma signalling through PLC beta 12 4.48e-01 5.52e-01 0.22700 -0.119000 -0.193000 4.75e-01 2.47e-01
Presynaptic function of Kainate receptors 12 4.48e-01 5.52e-01 0.22700 -0.119000 -0.193000 4.75e-01 2.47e-01
Regulation of TP53 Activity through Association with Co-factors 12 3.96e-01 5.14e-01 0.22700 0.017600 0.226000 9.16e-01 1.75e-01
Receptor Mediated Mitophagy 11 3.71e-01 4.93e-01 0.22700 0.205000 -0.097200 2.40e-01 5.77e-01
Metalloprotease DUBs 15 3.28e-01 4.55e-01 0.22500 0.223000 0.033800 1.36e-01 8.21e-01
Signaling by GPCR 270 9.23e-11 2.99e-09 0.22500 -0.211000 0.078500 2.92e-09 2.74e-02
Regulation of Complement cascade 13 3.35e-01 4.62e-01 0.22500 0.047700 -0.220000 7.66e-01 1.70e-01
Intra-Golgi traffic 38 8.38e-02 1.72e-01 0.22500 0.128000 0.185000 1.72e-01 4.85e-02
Homology Directed Repair 82 4.87e-03 2.02e-02 0.22500 0.186000 0.126000 3.66e-03 4.83e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 16 2.50e-01 3.78e-01 0.22500 -0.074700 0.212000 6.05e-01 1.43e-01
p75 NTR receptor-mediated signalling 73 1.29e-03 6.68e-03 0.22400 -0.155000 0.162000 2.24e-02 1.67e-02
ESR-mediated signaling 126 3.40e-04 2.10e-03 0.22400 0.148000 0.169000 4.34e-03 1.12e-03
Signaling by EGFR 41 5.18e-02 1.26e-01 0.22400 0.043400 0.220000 6.31e-01 1.50e-02
Regulation of PTEN mRNA translation 11 4.77e-01 5.75e-01 0.22400 0.090400 0.205000 6.04e-01 2.40e-01
GPCR downstream signalling 245 8.93e-10 2.29e-08 0.22400 -0.207000 0.083400 2.64e-08 2.55e-02
HSF1 activation 22 2.45e-01 3.73e-01 0.22300 0.179000 0.134000 1.47e-01 2.77e-01
Transcriptional activation of mitochondrial biogenesis 47 3.62e-02 9.63e-02 0.22200 -0.045300 -0.217000 5.91e-01 1.00e-02
Lysosome Vesicle Biogenesis 27 1.75e-01 2.91e-01 0.22200 0.108000 0.194000 3.32e-01 8.18e-02
Cell Cycle 484 1.10e-13 5.87e-12 0.22200 0.193000 0.110000 7.18e-13 4.51e-05
Nucleotide Excision Repair 102 7.22e-04 3.98e-03 0.22100 0.218000 0.034900 1.43e-04 5.44e-01
Retrograde transport at the Trans-Golgi-Network 43 2.38e-02 6.92e-02 0.22100 0.191000 -0.111000 3.05e-02 2.07e-01
Tie2 Signaling 13 4.46e-01 5.52e-01 0.22100 0.158000 0.154000 3.24e-01 3.36e-01
Interleukin-2 family signaling 22 1.43e-01 2.51e-01 0.22100 -0.168000 0.143000 1.73e-01 2.44e-01
Neuronal System 174 1.02e-06 1.44e-05 0.22100 -0.216000 0.043100 9.32e-07 3.29e-01
Metabolic disorders of biological oxidation enzymes 13 4.44e-01 5.52e-01 0.22000 -0.180000 -0.127000 2.62e-01 4.28e-01
Cargo concentration in the ER 21 2.45e-01 3.73e-01 0.22000 0.209000 0.067900 9.73e-02 5.90e-01
M Phase 275 3.46e-08 7.24e-07 0.22000 0.195000 0.101000 3.05e-08 4.17e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66 3.67e-03 1.60e-02 0.22000 -0.101000 0.195000 1.56e-01 6.25e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.09e-01 5.96e-01 0.21900 -0.140000 -0.168000 4.20e-01 3.33e-01
Regulation of TP53 Degradation 32 1.17e-01 2.18e-01 0.21900 0.210000 0.063000 3.99e-02 5.38e-01
Inactivation, recovery and regulation of the phototransduction cascade 13 3.31e-01 4.58e-01 0.21900 -0.102000 0.194000 5.26e-01 2.26e-01
The phototransduction cascade 13 3.31e-01 4.58e-01 0.21900 -0.102000 0.194000 5.26e-01 2.26e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 10 5.30e-01 6.15e-01 0.21900 0.194000 0.102000 2.88e-01 5.78e-01
PCNA-Dependent Long Patch Base Excision Repair 21 2.68e-01 3.95e-01 0.21900 0.189000 0.111000 1.34e-01 3.80e-01
Regulation of PTEN gene transcription 58 1.96e-02 5.91e-02 0.21800 0.048500 0.213000 5.24e-01 5.08e-03
Metabolism of vitamins and cofactors 126 2.87e-04 1.82e-03 0.21800 -0.071400 -0.206000 1.68e-01 6.88e-05
Post-translational protein phosphorylation 63 5.57e-03 2.27e-02 0.21800 -0.086400 0.200000 2.37e-01 6.15e-03
WNT5A-dependent internalization of FZD4 13 3.38e-01 4.65e-01 0.21800 -0.196000 0.095200 2.22e-01 5.53e-01
Uptake and actions of bacterial toxins 21 1.66e-01 2.79e-01 0.21800 -0.127000 0.177000 3.15e-01 1.61e-01
Ion channel transport 91 3.52e-03 1.54e-02 0.21700 -0.193000 -0.099600 1.48e-03 1.01e-01
MAP2K and MAPK activation 31 8.09e-02 1.70e-01 0.21700 -0.074100 0.204000 4.76e-01 4.93e-02
Activation of BH3-only proteins 25 1.27e-01 2.26e-01 0.21700 -0.090900 0.197000 4.32e-01 8.80e-02
COPI-dependent Golgi-to-ER retrograde traffic 62 2.42e-02 6.98e-02 0.21700 0.137000 0.169000 6.32e-02 2.18e-02
APC-Cdc20 mediated degradation of Nek2A 21 1.73e-01 2.89e-01 0.21700 0.192000 -0.102000 1.29e-01 4.18e-01
Cell Cycle, Mitotic 397 7.59e-11 2.53e-09 0.21600 0.182000 0.116000 6.23e-10 8.34e-05
RUNX3 regulates NOTCH signaling 13 4.39e-01 5.50e-01 0.21600 0.080200 0.201000 6.17e-01 2.11e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 24 1.33e-01 2.36e-01 0.21500 -0.143000 0.161000 2.26e-01 1.72e-01
EGFR downregulation 22 2.74e-01 4.00e-01 0.21500 0.154000 0.151000 2.12e-01 2.21e-01
Plasma lipoprotein assembly, remodeling, and clearance 39 7.90e-02 1.67e-01 0.21500 -0.208000 -0.053000 2.47e-02 5.67e-01
Early Phase of HIV Life Cycle 11 5.25e-01 6.11e-01 0.21400 0.149000 0.155000 3.93e-01 3.75e-01
Signaling by BRAF and RAF fusions 52 1.42e-02 4.73e-02 0.21300 -0.173000 0.124000 3.07e-02 1.22e-01
Death Receptor Signalling 106 1.78e-04 1.21e-03 0.21300 -0.171000 0.127000 2.36e-03 2.45e-02
Oxidative Stress Induced Senescence 59 2.53e-02 7.24e-02 0.21300 0.068800 0.202000 3.61e-01 7.48e-03
Chaperonin-mediated protein folding 69 1.69e-02 5.35e-02 0.21300 0.106000 0.185000 1.29e-01 8.07e-03
Golgi Cisternae Pericentriolar Stack Reorganization 11 5.18e-01 6.04e-01 0.21300 0.189000 0.098500 2.79e-01 5.72e-01
Signaling by NTRK3 (TRKC) 16 2.68e-01 3.95e-01 0.21300 -0.155000 0.145000 2.82e-01 3.15e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 2.12e-01 3.34e-01 0.21300 0.171000 -0.126000 1.96e-01 3.43e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 2.12e-01 3.34e-01 0.21300 0.171000 -0.126000 1.96e-01 3.43e-01
Reproduction 44 4.49e-02 1.12e-01 0.21200 0.212000 -0.007790 1.49e-02 9.29e-01
DNA Double-Strand Break Repair 109 1.73e-03 8.58e-03 0.21200 0.183000 0.107000 9.98e-04 5.33e-02
Cytosolic sensors of pathogen-associated DNA 52 4.60e-02 1.14e-01 0.21100 0.190000 0.091500 1.77e-02 2.54e-01
Arachidonic acid metabolism 19 3.43e-01 4.70e-01 0.21000 -0.153000 -0.144000 2.47e-01 2.78e-01
ZBP1(DAI) mediated induction of type I IFNs 17 3.70e-01 4.93e-01 0.21000 0.094900 0.188000 4.99e-01 1.81e-01
Insulin receptor signalling cascade 32 1.30e-01 2.31e-01 0.21000 0.037300 0.207000 7.15e-01 4.32e-02
Pre-NOTCH Expression and Processing 45 3.10e-02 8.49e-02 0.21000 -0.090400 0.189000 2.94e-01 2.82e-02
Transport of vitamins, nucleosides, and related molecules 24 1.75e-01 2.90e-01 0.21000 -0.205000 0.042200 8.17e-02 7.20e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 15 3.03e-01 4.32e-01 0.21000 -0.125000 0.169000 4.03e-01 2.59e-01
G beta:gamma signalling through BTK 10 5.37e-01 6.21e-01 0.21000 -0.052000 -0.203000 7.76e-01 2.66e-01
Interleukin-7 signaling 12 3.85e-01 5.06e-01 0.21000 -0.168000 0.126000 3.15e-01 4.51e-01
Metabolism 1377 2.01e-30 3.54e-28 0.20900 -0.115000 -0.175000 4.70e-12 9.42e-26
Platelet degranulation 86 1.14e-03 5.98e-03 0.20900 -0.142000 0.153000 2.28e-02 1.46e-02
Diseases of glycosylation 97 5.48e-04 3.16e-03 0.20900 -0.110000 0.178000 6.25e-02 2.57e-03
FOXO-mediated transcription of cell cycle genes 16 2.83e-01 4.12e-01 0.20900 -0.163000 0.130000 2.58e-01 3.69e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 16 4.05e-01 5.23e-01 0.20800 -0.177000 -0.110000 2.21e-01 4.45e-01
Regulation of TP53 Expression and Degradation 33 1.25e-01 2.26e-01 0.20800 0.205000 0.036000 4.16e-02 7.21e-01
Signaling by Receptor Tyrosine Kinases 357 1.47e-11 5.32e-10 0.20800 -0.046200 0.203000 1.37e-01 6.49e-11
IGF1R signaling cascade 30 1.48e-01 2.57e-01 0.20800 0.027800 0.206000 7.92e-01 5.09e-02
Purine salvage 13 4.30e-01 5.42e-01 0.20800 -0.207000 -0.015500 1.96e-01 9.23e-01
Cytosolic sulfonation of small molecules 11 4.64e-01 5.65e-01 0.20700 0.029400 -0.205000 8.66e-01 2.38e-01
VEGFR2 mediated vascular permeability 23 1.80e-01 2.96e-01 0.20700 -0.078900 0.192000 5.13e-01 1.12e-01
Opioid Signalling 64 2.13e-02 6.33e-02 0.20700 -0.200000 -0.051000 5.66e-03 4.81e-01
Signaling by NODAL 10 4.63e-01 5.65e-01 0.20700 -0.168000 0.120000 3.58e-01 5.11e-01
Influenza Infection 107 2.93e-03 1.33e-02 0.20700 0.169000 0.118000 2.56e-03 3.47e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 73 9.66e-03 3.51e-02 0.20600 0.206000 0.017200 2.42e-03 7.99e-01
Signaling by EGFR in Cancer 18 3.72e-01 4.93e-01 0.20600 0.112000 0.173000 4.13e-01 2.04e-01
Signaling by BMP 23 1.97e-01 3.17e-01 0.20600 -0.046600 0.200000 6.99e-01 9.62e-02
Cytochrome P450 - arranged by substrate type 18 3.56e-01 4.82e-01 0.20600 -0.191000 -0.077300 1.62e-01 5.70e-01
Interconversion of nucleotide di- and triphosphates 21 3.10e-01 4.38e-01 0.20600 -0.096500 -0.182000 4.44e-01 1.50e-01
RAB geranylgeranylation 41 6.84e-02 1.54e-01 0.20600 0.206000 -0.002180 2.29e-02 9.81e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.22e-01 2.20e-01 0.20500 0.060100 0.196000 5.33e-01 4.19e-02
Synthesis of PC 21 3.13e-01 4.41e-01 0.20500 -0.095500 -0.181000 4.49e-01 1.51e-01
SUMOylation of DNA methylation proteins 15 4.42e-01 5.52e-01 0.20400 0.105000 0.175000 4.83e-01 2.40e-01
LDL clearance 14 4.21e-01 5.37e-01 0.20400 0.022900 0.203000 8.82e-01 1.89e-01
Signaling by Interleukins 278 5.65e-09 1.29e-07 0.20400 -0.054200 0.196000 1.23e-01 2.17e-08
Constitutive Signaling by NOTCH1 HD Domain Mutants 11 5.09e-01 5.96e-01 0.20300 -0.202000 -0.024300 2.46e-01 8.89e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 11 5.09e-01 5.96e-01 0.20300 -0.202000 -0.024300 2.46e-01 8.89e-01
Complement cascade 14 4.14e-01 5.31e-01 0.20300 -0.008390 -0.203000 9.57e-01 1.88e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 13 4.99e-01 5.90e-01 0.20300 0.113000 0.169000 4.82e-01 2.91e-01
Leishmania infection 118 2.31e-04 1.51e-03 0.20300 -0.079100 0.187000 1.39e-01 4.77e-04
RUNX2 regulates bone development 26 1.82e-01 2.98e-01 0.20300 -0.019000 0.202000 8.67e-01 7.51e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 2.65e-01 3.92e-01 0.20100 -0.189000 0.068800 1.53e-01 6.04e-01
Trafficking of AMPA receptors 19 2.65e-01 3.92e-01 0.20100 -0.189000 0.068800 1.53e-01 6.04e-01
G2/M Checkpoints 106 4.03e-03 1.73e-02 0.20100 0.171000 0.105000 2.38e-03 6.34e-02
Transport of bile salts and organic acids, metal ions and amine compounds 32 1.02e-01 1.97e-01 0.20000 -0.099100 0.174000 3.32e-01 8.83e-02
Activation of HOX genes during differentiation 50 7.79e-02 1.66e-01 0.20000 0.154000 0.128000 5.95e-02 1.19e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 50 7.79e-02 1.66e-01 0.20000 0.154000 0.128000 5.95e-02 1.19e-01
Synthesis of PA 21 3.42e-01 4.70e-01 0.20000 -0.132000 -0.150000 2.95e-01 2.33e-01
RNA Polymerase III Abortive And Retractive Initiation 39 1.09e-01 2.08e-01 0.20000 0.195000 0.045300 3.56e-02 6.25e-01
RNA Polymerase III Transcription 39 1.09e-01 2.08e-01 0.20000 0.195000 0.045300 3.56e-02 6.25e-01
HDR through Homologous Recombination (HRR) 49 8.09e-02 1.70e-01 0.19900 0.170000 0.102000 3.95e-02 2.16e-01
Activation of NMDA receptors and postsynaptic events 52 2.82e-02 7.90e-02 0.19800 -0.180000 0.082500 2.48e-02 3.04e-01
Fanconi Anemia Pathway 25 1.95e-01 3.15e-01 0.19800 0.193000 -0.044800 9.50e-02 6.99e-01
HDR through Single Strand Annealing (SSA) 30 1.74e-01 2.90e-01 0.19800 0.197000 0.020000 6.21e-02 8.50e-01
Platelet activation, signaling and aggregation 169 9.56e-06 8.60e-05 0.19800 -0.093600 0.174000 3.65e-02 1.00e-04
L1CAM interactions 70 7.25e-03 2.75e-02 0.19700 -0.145000 0.134000 3.68e-02 5.28e-02
TBC/RABGAPs 39 1.22e-01 2.20e-01 0.19700 0.056800 0.189000 5.40e-01 4.17e-02
Initiation of Nuclear Envelope (NE) Reformation 17 3.74e-01 4.95e-01 0.19700 0.196000 0.018400 1.62e-01 8.95e-01
Metabolism of nitric oxide: NOS3 activation and regulation 13 4.01e-01 5.19e-01 0.19700 -0.141000 0.137000 3.77e-01 3.94e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 4.49e-01 5.52e-01 0.19600 0.061000 0.187000 6.83e-01 2.11e-01
Protein ubiquitination 56 5.19e-02 1.26e-01 0.19600 0.185000 0.064500 1.65e-02 4.04e-01
Inositol phosphate metabolism 39 7.84e-02 1.66e-01 0.19600 -0.187000 0.058200 4.32e-02 5.30e-01
Protein folding 75 2.23e-02 6.54e-02 0.19600 0.084000 0.177000 2.09e-01 8.30e-03
Biological oxidations 85 1.64e-02 5.28e-02 0.19500 -0.141000 -0.135000 2.49e-02 3.13e-02
Integration of energy metabolism 72 1.71e-02 5.38e-02 0.19500 -0.194000 -0.021000 4.42e-03 7.59e-01
VEGFR2 mediated cell proliferation 16 3.34e-01 4.62e-01 0.19500 -0.159000 0.113000 2.72e-01 4.35e-01
COPII-mediated vesicle transport 56 5.68e-02 1.33e-01 0.19500 0.181000 0.072700 1.96e-02 3.47e-01
Metabolism of amino acids and derivatives 226 1.18e-05 1.02e-04 0.19500 -0.075100 -0.180000 5.32e-02 3.70e-06
Neurotransmitter receptors and postsynaptic signal transmission 96 3.38e-03 1.49e-02 0.19500 -0.194000 0.010700 1.03e-03 8.57e-01
Apoptotic cleavage of cellular proteins 27 1.56e-01 2.68e-01 0.19500 -0.126000 0.148000 2.56e-01 1.84e-01
Global Genome Nucleotide Excision Repair (GG-NER) 78 1.30e-02 4.44e-02 0.19400 0.193000 0.023100 3.25e-03 7.24e-01
Response to elevated platelet cytosolic Ca2+ 89 2.30e-03 1.09e-02 0.19400 -0.138000 0.136000 2.42e-02 2.66e-02
Other semaphorin interactions 14 4.03e-01 5.21e-01 0.19400 -0.183000 0.065900 2.37e-01 6.70e-01
Signaling by NTRK2 (TRKB) 21 3.01e-01 4.30e-01 0.19400 0.009540 0.194000 9.40e-01 1.24e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 4.13e-01 5.30e-01 0.19400 0.116000 -0.155000 4.69e-01 3.32e-01
Thrombin signalling through proteinase activated receptors (PARs) 20 2.84e-01 4.13e-01 0.19300 -0.049800 0.187000 7.00e-01 1.48e-01
Activation of kainate receptors upon glutamate binding 17 4.21e-01 5.37e-01 0.19300 -0.180000 -0.068400 1.98e-01 6.25e-01
DNA Repair 242 4.63e-06 4.57e-05 0.19300 0.184000 0.057400 9.08e-07 1.26e-01
Metabolism of nucleotides 74 3.02e-02 8.33e-02 0.19300 -0.151000 -0.119000 2.45e-02 7.68e-02
Carboxyterminal post-translational modifications of tubulin 21 2.44e-01 3.73e-01 0.19300 -0.153000 0.117000 2.24e-01 3.55e-01
mRNA decay by 5' to 3' exoribonuclease 14 3.89e-01 5.10e-01 0.19300 0.143000 -0.129000 3.55e-01 4.03e-01
Synthesis of PIPs at the plasma membrane 44 1.20e-01 2.18e-01 0.19200 0.095500 0.167000 2.73e-01 5.58e-02
Signaling by KIT in disease 17 3.21e-01 4.47e-01 0.19200 -0.139000 0.132000 3.21e-01 3.47e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 3.21e-01 4.47e-01 0.19200 -0.139000 0.132000 3.21e-01 3.47e-01
Hemostasis 349 1.51e-10 4.65e-09 0.19200 -0.141000 0.130000 7.12e-06 3.65e-05
TRAF6 mediated IRF7 activation 14 4.76e-01 5.75e-01 0.19200 0.036700 0.188000 8.12e-01 2.23e-01
Miscellaneous transport and binding events 16 3.46e-01 4.74e-01 0.19100 0.150000 -0.119000 2.99e-01 4.11e-01
Interferon alpha/beta signaling 36 1.27e-01 2.27e-01 0.19100 -0.008140 0.191000 9.33e-01 4.75e-02
Post NMDA receptor activation events 44 7.17e-02 1.59e-01 0.19100 -0.188000 0.034700 3.12e-02 6.91e-01
Diseases associated with N-glycosylation of proteins 16 4.76e-01 5.75e-01 0.19100 0.130000 0.140000 3.68e-01 3.33e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.99e-01 3.19e-01 0.18900 -0.177000 0.068400 1.19e-01 5.47e-01
Clathrin-mediated endocytosis 109 6.39e-03 2.53e-02 0.18900 0.098700 0.162000 7.59e-02 3.62e-03
Synthesis of glycosylphosphatidylinositol (GPI) 15 3.81e-01 5.03e-01 0.18800 0.131000 -0.135000 3.80e-01 3.66e-01
DNA strand elongation 30 2.60e-01 3.87e-01 0.18800 0.136000 0.130000 1.98e-01 2.18e-01
NOTCH4 Intracellular Domain Regulates Transcription 15 4.44e-01 5.52e-01 0.18700 0.001610 0.187000 9.91e-01 2.09e-01
Acyl chain remodelling of PC 12 4.67e-01 5.67e-01 0.18700 0.111000 -0.151000 5.05e-01 3.66e-01
Signal transduction by L1 20 2.81e-01 4.09e-01 0.18700 -0.130000 0.134000 3.13e-01 3.01e-01
Class A/1 (Rhodopsin-like receptors) 39 9.04e-02 1.81e-01 0.18700 -0.088900 0.164000 3.37e-01 7.66e-02
Formation of Incision Complex in GG-NER 39 9.59e-02 1.88e-01 0.18600 0.173000 -0.068700 6.14e-02 4.58e-01
RNA Polymerase I Promoter Clearance 43 1.43e-01 2.51e-01 0.18600 0.161000 0.093200 6.78e-02 2.91e-01
Neutrophil degranulation 292 4.53e-08 9.32e-07 0.18600 -0.060700 0.176000 7.65e-02 2.79e-07
Transmission across Chemical Synapses 124 1.36e-03 6.98e-03 0.18400 -0.183000 0.014000 4.33e-04 7.88e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 30 2.65e-01 3.92e-01 0.18400 0.161000 0.088700 1.28e-01 4.01e-01
Acyl chain remodelling of PE 11 5.39e-01 6.23e-01 0.18400 0.179000 -0.040700 3.04e-01 8.15e-01
IRS-related events triggered by IGF1R 29 2.23e-01 3.47e-01 0.18300 0.000983 0.183000 9.93e-01 8.77e-02
Golgi-to-ER retrograde transport 89 2.12e-02 6.33e-02 0.18300 0.099000 0.154000 1.07e-01 1.21e-02
APC/C:Cdc20 mediated degradation of Cyclin B 20 3.09e-01 4.38e-01 0.18200 0.163000 -0.081500 2.07e-01 5.29e-01
G1/S-Specific Transcription 21 4.11e-01 5.28e-01 0.18200 0.138000 0.119000 2.75e-01 3.44e-01
Recycling pathway of L1 23 2.81e-01 4.09e-01 0.18200 -0.041700 0.177000 7.29e-01 1.42e-01
PI3K Cascade 23 3.21e-01 4.47e-01 0.18200 0.015100 0.181000 9.01e-01 1.33e-01
Cytokine Signaling in Immune system 518 2.97e-12 1.31e-10 0.18200 -0.027500 0.179000 2.91e-01 4.94e-12
NOTCH3 Activation and Transmission of Signal to the Nucleus 21 3.69e-01 4.93e-01 0.18100 -0.178000 -0.034300 1.58e-01 7.86e-01
Rap1 signalling 14 5.43e-01 6.26e-01 0.18100 0.078500 0.163000 6.11e-01 2.91e-01
Chromatin modifying enzymes 180 6.66e-04 3.75e-03 0.18000 0.136000 0.118000 1.71e-03 6.77e-03
Chromatin organization 180 6.66e-04 3.75e-03 0.18000 0.136000 0.118000 1.71e-03 6.77e-03
Signaling by ERBB2 37 1.25e-01 2.26e-01 0.18000 -0.070900 0.165000 4.56e-01 8.25e-02
Trafficking of GluR2-containing AMPA receptors 10 5.69e-01 6.47e-01 0.17900 -0.162000 0.075900 3.75e-01 6.78e-01
PI Metabolism 69 5.62e-02 1.33e-01 0.17900 0.090200 0.155000 1.96e-01 2.66e-02
Signaling by ERBB2 TMD/JMD mutants 14 4.51e-01 5.53e-01 0.17700 -0.106000 0.142000 4.91e-01 3.58e-01
Gene expression (Transcription) 997 1.17e-17 7.57e-16 0.17700 0.166000 0.062500 4.98e-18 1.13e-03
FCERI mediated MAPK activation 23 3.23e-01 4.50e-01 0.17700 -0.005820 0.177000 9.61e-01 1.42e-01
G alpha (s) signalling events 51 1.18e-01 2.18e-01 0.17700 -0.161000 -0.073100 4.66e-02 3.67e-01
Nervous system development 395 4.08e-10 1.20e-08 0.17700 -0.117000 0.132000 7.65e-05 7.97e-06
IRS-mediated signalling 27 2.97e-01 4.27e-01 0.17600 0.031000 0.173000 7.81e-01 1.19e-01
Glycogen synthesis 12 6.20e-01 6.93e-01 0.17600 -0.144000 -0.099900 3.87e-01 5.49e-01
Signaling by ERBB2 in Cancer 18 4.18e-01 5.34e-01 0.17500 -0.012200 0.175000 9.28e-01 2.00e-01
Interleukin-1 family signaling 102 1.24e-02 4.34e-02 0.17400 0.040000 0.170000 4.86e-01 3.11e-03
Signaling by Erythropoietin 19 3.59e-01 4.84e-01 0.17400 -0.085800 0.152000 5.17e-01 2.53e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 3.99e-01 5.17e-01 0.17400 0.155000 0.079100 1.99e-01 5.12e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 52 6.89e-02 1.55e-01 0.17400 -0.054400 0.165000 4.98e-01 3.97e-02
Phosphorylation of the APC/C 18 3.76e-01 4.97e-01 0.17300 0.139000 -0.104000 3.08e-01 4.45e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 14 5.09e-01 5.96e-01 0.17300 0.172000 -0.019200 2.65e-01 9.01e-01
Aggrephagy 16 5.09e-01 5.96e-01 0.17300 0.046900 0.167000 7.45e-01 2.48e-01
RNA Polymerase I Transcription 44 1.82e-01 2.98e-01 0.17300 0.144000 0.095600 9.77e-02 2.73e-01
Infectious disease 533 2.47e-09 6.08e-08 0.17300 0.091300 0.147000 3.74e-04 9.46e-09
Costimulation by the CD28 family 39 1.59e-01 2.70e-01 0.17300 -0.009620 0.173000 9.17e-01 6.20e-02
Signaling by TGF-beta Receptor Complex 66 8.16e-02 1.70e-01 0.17300 0.119000 0.126000 9.64e-02 7.68e-02
Phase II - Conjugation of compounds 46 1.58e-01 2.70e-01 0.17300 -0.067500 -0.159000 4.29e-01 6.24e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 75 5.44e-02 1.30e-01 0.17300 0.150000 0.085700 2.51e-02 2.00e-01
Regulation of beta-cell development 17 4.08e-01 5.25e-01 0.17200 -0.087000 0.148000 5.35e-01 2.90e-01
DNA Damage Recognition in GG-NER 34 1.99e-01 3.19e-01 0.17100 0.170000 -0.023400 8.69e-02 8.13e-01
Role of phospholipids in phagocytosis 14 5.00e-01 5.91e-01 0.17100 -0.165000 0.046000 2.85e-01 7.66e-01
VLDLR internalisation and degradation 11 6.22e-01 6.94e-01 0.17100 -0.170000 -0.023000 3.30e-01 8.95e-01
Signal Transduction 1401 1.02e-27 1.25e-25 0.17100 -0.064200 0.158000 1.03e-04 9.04e-22
MAP3K8 (TPL2)-dependent MAPK1/3 activation 13 5.57e-01 6.37e-01 0.17000 -0.002050 0.170000 9.90e-01 2.88e-01
Prostacyclin signalling through prostacyclin receptor 12 6.37e-01 7.06e-01 0.17000 -0.089200 -0.145000 5.93e-01 3.86e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 5.65e-01 6.44e-01 0.17000 -0.033100 0.166000 8.43e-01 3.18e-01
GPCR ligand binding 74 4.16e-02 1.06e-01 0.16900 -0.169000 -0.009760 1.23e-02 8.85e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 148 5.03e-03 2.07e-02 0.16800 0.129000 0.108000 6.87e-03 2.38e-02
Removal of the Flap Intermediate 14 5.55e-01 6.36e-01 0.16800 0.167000 0.019300 2.79e-01 9.00e-01
PIP3 activates AKT signaling 212 2.52e-04 1.64e-03 0.16800 0.044500 0.162000 2.66e-01 5.10e-05
Sphingolipid metabolism 64 5.04e-02 1.23e-01 0.16800 -0.036000 0.164000 6.19e-01 2.33e-02
Signaling by Insulin receptor 48 1.48e-01 2.57e-01 0.16800 0.041700 0.163000 6.18e-01 5.15e-02
Downregulation of TGF-beta receptor signaling 24 4.24e-01 5.39e-01 0.16800 0.115000 0.122000 3.29e-01 3.01e-01
DNA Damage Bypass 43 1.96e-01 3.16e-01 0.16800 0.155000 0.063900 7.92e-02 4.69e-01
Gap junction trafficking 11 6.70e-01 7.31e-01 0.16700 0.089000 0.142000 6.09e-01 4.16e-01
TRAF3-dependent IRF activation pathway 12 5.47e-01 6.29e-01 0.16600 -0.114000 0.121000 4.95e-01 4.68e-01
Toll Like Receptor 4 (TLR4) Cascade 102 9.32e-03 3.41e-02 0.16500 -0.046700 0.158000 4.17e-01 5.82e-03
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 19 3.92e-01 5.11e-01 0.16500 -0.101000 0.130000 4.44e-01 3.27e-01
Regulation of FZD by ubiquitination 11 5.83e-01 6.60e-01 0.16500 -0.101000 0.130000 5.61e-01 4.56e-01
Potential therapeutics for SARS 66 5.53e-02 1.31e-01 0.16400 -0.026600 0.162000 7.09e-01 2.30e-02
Gastrin-CREB signalling pathway via PKC and MAPK 15 5.36e-01 6.20e-01 0.16400 -0.000157 0.164000 9.99e-01 2.72e-01
Influenza Viral RNA Transcription and Replication 91 3.40e-02 9.20e-02 0.16400 0.157000 0.048600 9.98e-03 4.24e-01
RNA Polymerase III Transcription Termination 22 3.68e-01 4.93e-01 0.16300 0.154000 -0.052600 2.11e-01 6.70e-01
Transport of small molecules 410 1.26e-06 1.69e-05 0.16300 -0.136000 -0.090100 2.99e-06 1.94e-03
Resolution of D-Loop Structures 21 4.93e-01 5.84e-01 0.16300 0.118000 0.112000 3.50e-01 3.73e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 21 4.93e-01 5.84e-01 0.16300 0.118000 0.112000 3.50e-01 3.73e-01
Metabolism of carbohydrates 205 1.17e-04 8.20e-04 0.16200 -0.154000 0.050100 1.49e-04 2.19e-01
MicroRNA (miRNA) biogenesis 22 4.24e-01 5.39e-01 0.16200 0.161000 0.015500 1.92e-01 9.00e-01
DNA Replication 111 1.90e-02 5.78e-02 0.16200 0.153000 0.051300 5.43e-03 3.52e-01
Gap junction trafficking and regulation 13 6.19e-01 6.93e-01 0.16000 0.033400 0.157000 8.35e-01 3.28e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 16 5.59e-01 6.39e-01 0.16000 0.040600 0.155000 7.79e-01 2.83e-01
Extra-nuclear estrogen signaling 53 1.48e-01 2.57e-01 0.16000 0.041600 0.155000 6.01e-01 5.16e-02
Dual Incision in GG-NER 38 2.08e-01 3.30e-01 0.16000 0.159000 -0.021500 9.10e-02 8.19e-01
AKT phosphorylates targets in the cytosol 14 5.38e-01 6.22e-01 0.16000 -0.148000 0.060500 3.39e-01 6.95e-01
Retrograde neurotrophin signalling 11 6.63e-01 7.24e-01 0.16000 0.022800 0.158000 8.96e-01 3.65e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 19 4.15e-01 5.31e-01 0.16000 0.116000 -0.109000 3.81e-01 4.09e-01
PKMTs methylate histone lysines 37 2.71e-01 3.97e-01 0.16000 0.152000 0.047400 1.09e-01 6.18e-01
Oncogenic MAPK signaling 68 4.38e-02 1.10e-01 0.15900 -0.111000 0.115000 1.15e-01 1.03e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 3.17e-01 4.46e-01 0.15900 0.114000 -0.111000 3.26e-01 3.36e-01
Apoptotic execution phase 35 2.29e-01 3.56e-01 0.15800 -0.039600 0.153000 6.85e-01 1.17e-01
Eukaryotic Translation Elongation 56 1.64e-01 2.78e-01 0.15800 -0.088300 -0.131000 2.54e-01 8.95e-02
Interleukin-12 family signaling 36 2.49e-01 3.77e-01 0.15800 0.000371 0.158000 9.97e-01 1.01e-01
Transcriptional regulation of white adipocyte differentiation 71 9.17e-02 1.82e-01 0.15800 0.147000 0.058300 3.29e-02 3.97e-01
Anti-inflammatory response favouring Leishmania parasite infection 56 1.05e-01 2.01e-01 0.15800 -0.156000 0.022800 4.35e-02 7.69e-01
Leishmania parasite growth and survival 56 1.05e-01 2.01e-01 0.15800 -0.156000 0.022800 4.35e-02 7.69e-01
TRAF6 mediated NF-kB activation 19 4.29e-01 5.42e-01 0.15800 -0.134000 0.082700 3.11e-01 5.33e-01
MHC class II antigen presentation 71 1.04e-01 2.00e-01 0.15800 0.090400 0.129000 1.89e-01 6.04e-02
Axon guidance 378 7.35e-08 1.46e-06 0.15700 -0.103000 0.119000 6.49e-04 8.57e-05
Apoptotic factor-mediated response 13 6.00e-01 6.74e-01 0.15700 -0.014800 0.156000 9.27e-01 3.30e-01
RUNX2 regulates osteoblast differentiation 20 4.37e-01 5.49e-01 0.15700 -0.041200 0.151000 7.50e-01 2.42e-01
TGF-beta receptor signaling activates SMADs 29 4.02e-01 5.19e-01 0.15700 0.095000 0.125000 3.76e-01 2.46e-01
ADORA2B mediated anti-inflammatory cytokines production 38 2.95e-01 4.25e-01 0.15600 -0.139000 -0.070900 1.39e-01 4.50e-01
G2/M Transition 153 6.97e-03 2.69e-02 0.15600 0.144000 0.059200 2.17e-03 2.08e-01
RAS processing 18 5.07e-01 5.96e-01 0.15600 -0.156000 0.002350 2.53e-01 9.86e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 18 4.58e-01 5.60e-01 0.15500 -0.084400 0.130000 5.36e-01 3.38e-01
Neurodegenerative Diseases 18 4.58e-01 5.60e-01 0.15500 -0.084400 0.130000 5.36e-01 3.38e-01
MyD88-independent TLR4 cascade 83 2.99e-02 8.28e-02 0.15500 -0.070600 0.138000 2.67e-01 2.99e-02
TRIF(TICAM1)-mediated TLR4 signaling 83 2.99e-02 8.28e-02 0.15500 -0.070600 0.138000 2.67e-01 2.99e-02
G beta:gamma signalling through CDC42 13 6.32e-01 7.01e-01 0.15400 -0.016200 -0.153000 9.20e-01 3.39e-01
Signaling by WNT in cancer 28 3.90e-01 5.10e-01 0.15400 0.036300 0.150000 7.40e-01 1.71e-01
Signaling by FGFR in disease 47 2.36e-01 3.63e-01 0.15400 0.078800 0.132000 3.50e-01 1.18e-01
Signal amplification 20 5.29e-01 6.14e-01 0.15400 0.058800 0.142000 6.49e-01 2.72e-01
Cargo recognition for clathrin-mediated endocytosis 73 1.14e-01 2.14e-01 0.15300 0.116000 0.101000 8.84e-02 1.38e-01
RNA Polymerase I Transcription Initiation 40 2.77e-01 4.05e-01 0.15300 0.144000 0.052300 1.16e-01 5.67e-01
Innate Immune System 608 1.37e-10 4.33e-09 0.15300 -0.043100 0.146000 7.38e-02 1.22e-09
Mitotic G2-G2/M phases 155 8.94e-03 3.29e-02 0.15200 0.137000 0.067200 3.44e-03 1.50e-01
Transcriptional Regulation by MECP2 42 2.20e-01 3.45e-01 0.15200 -0.152000 0.005810 8.90e-02 9.48e-01
Nucleobase catabolism 21 5.08e-01 5.96e-01 0.15200 -0.146000 -0.040300 2.47e-01 7.49e-01
DNA Replication Pre-Initiation 70 1.16e-01 2.17e-01 0.15100 0.139000 0.058600 4.40e-02 3.97e-01
Removal of the Flap Intermediate from the C-strand 17 5.10e-01 5.96e-01 0.15100 0.138000 -0.060600 3.25e-01 6.66e-01
Factors involved in megakaryocyte development and platelet production 80 3.79e-02 9.94e-02 0.15100 -0.114000 0.098100 7.82e-02 1.30e-01
Synthesis of DNA 106 3.38e-02 9.15e-02 0.15000 0.147000 0.033400 9.33e-03 5.54e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 28 4.43e-01 5.52e-01 0.15000 -0.084100 -0.124000 4.42e-01 2.55e-01
Toll-like Receptor Cascades 115 1.44e-02 4.78e-02 0.15000 -0.029600 0.147000 5.84e-01 6.55e-03
STING mediated induction of host immune responses 11 6.94e-01 7.53e-01 0.15000 0.149000 0.018300 3.93e-01 9.17e-01
S Phase 144 1.19e-02 4.15e-02 0.15000 0.143000 0.044500 3.17e-03 3.58e-01
Regulation of PLK1 Activity at G2/M Transition 74 1.20e-01 2.18e-01 0.14900 0.125000 0.080600 6.24e-02 2.31e-01
CD28 co-stimulation 25 3.82e-01 5.04e-01 0.14800 -0.060300 0.136000 6.02e-01 2.41e-01
AURKA Activation by TPX2 62 1.75e-01 2.90e-01 0.14800 0.121000 0.085900 1.01e-01 2.43e-01
Post-translational modification: synthesis of GPI-anchored proteins 36 2.87e-01 4.15e-01 0.14800 0.013500 -0.147000 8.89e-01 1.27e-01
Peptide ligand-binding receptors 22 4.27e-01 5.42e-01 0.14700 -0.071500 0.129000 5.62e-01 2.95e-01
Cyclin D associated events in G1 41 3.20e-01 4.47e-01 0.14600 0.078100 0.124000 3.87e-01 1.71e-01
G1 Phase 41 3.20e-01 4.47e-01 0.14600 0.078100 0.124000 3.87e-01 1.71e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 17 6.23e-01 6.94e-01 0.14600 0.076200 0.125000 5.86e-01 3.74e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 17 6.23e-01 6.94e-01 0.14600 0.076200 0.125000 5.86e-01 3.74e-01
RNA Polymerase II Transcription 889 3.86e-11 1.32e-09 0.14600 0.138000 0.046900 8.38e-12 2.04e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 63 9.98e-02 1.95e-01 0.14500 0.134000 -0.055900 6.60e-02 4.43e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 63 9.98e-02 1.95e-01 0.14500 0.134000 -0.055900 6.60e-02 4.43e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 5.84e-01 6.60e-01 0.14500 -0.013800 0.144000 9.24e-01 3.17e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 5.84e-01 6.60e-01 0.14500 -0.013800 0.144000 9.24e-01 3.17e-01
Interleukin-17 signaling 62 9.45e-02 1.86e-01 0.14500 -0.102000 0.103000 1.64e-01 1.63e-01
Intracellular signaling by second messengers 244 3.65e-04 2.22e-03 0.14400 -0.012000 0.144000 7.48e-01 1.20e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 7.48e-01 7.92e-01 0.14400 0.041200 0.138000 8.22e-01 4.49e-01
RIPK1-mediated regulated necrosis 22 4.49e-01 5.52e-01 0.14400 -0.131000 0.061000 2.90e-01 6.21e-01
Regulated Necrosis 22 4.49e-01 5.52e-01 0.14400 -0.131000 0.061000 2.90e-01 6.21e-01
Regulation of necroptotic cell death 22 4.49e-01 5.52e-01 0.14400 -0.131000 0.061000 2.90e-01 6.21e-01
RMTs methylate histone arginines 28 3.48e-01 4.76e-01 0.14400 -0.103000 0.101000 3.46e-01 3.57e-01
Signaling by ERBB2 KD Mutants 17 5.40e-01 6.23e-01 0.14400 -0.062100 0.129000 6.58e-01 3.56e-01
Transcriptional Regulation by TP53 307 3.20e-04 1.99e-03 0.14300 0.125000 0.069600 1.81e-04 3.74e-02
Cargo trafficking to the periciliary membrane 42 3.01e-01 4.30e-01 0.14300 0.137000 0.039900 1.23e-01 6.55e-01
APC/C-mediated degradation of cell cycle proteins 72 8.29e-02 1.72e-01 0.14200 0.135000 -0.046200 4.85e-02 4.98e-01
Regulation of mitotic cell cycle 72 8.29e-02 1.72e-01 0.14200 0.135000 -0.046200 4.85e-02 4.98e-01
Anchoring of the basal body to the plasma membrane 83 1.15e-01 2.15e-01 0.14200 0.121000 0.073600 5.66e-02 2.47e-01
G1/S Transition 112 5.25e-02 1.26e-01 0.14100 0.127000 0.062200 2.07e-02 2.56e-01
G alpha (q) signalling events 78 8.85e-02 1.79e-01 0.14100 -0.141000 0.006140 3.16e-02 9.25e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 7.08e-01 7.63e-01 0.14100 -0.008090 0.141000 9.63e-01 4.19e-01
Late endosomal microautophagy 23 4.49e-01 5.52e-01 0.14100 -0.127000 0.061400 2.94e-01 6.10e-01
Metabolism of steroid hormones 12 6.55e-01 7.19e-01 0.14000 -0.117000 0.077200 4.84e-01 6.43e-01
Synthesis of substrates in N-glycan biosythesis 52 1.60e-01 2.71e-01 0.14000 -0.107000 0.089600 1.82e-01 2.64e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 4.28e-01 5.42e-01 0.14000 0.112000 0.082900 2.58e-01 4.03e-01
Developmental Biology 588 3.93e-09 9.13e-08 0.14000 -0.070600 0.120000 3.97e-03 8.86e-07
Synthesis of very long-chain fatty acyl-CoAs 10 7.43e-01 7.90e-01 0.13900 0.002870 0.139000 9.87e-01 4.47e-01
Diseases of programmed cell death 24 4.48e-01 5.52e-01 0.13900 -0.051800 0.129000 6.61e-01 2.75e-01
Viral mRNA Translation 53 2.57e-01 3.84e-01 0.13800 -0.055000 -0.127000 4.89e-01 1.11e-01
Toll Like Receptor 3 (TLR3) Cascade 82 6.21e-02 1.44e-01 0.13800 -0.071700 0.118000 2.63e-01 6.52e-02
Protein methylation 10 7.43e-01 7.90e-01 0.13800 -0.004400 0.138000 9.81e-01 4.51e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 19 5.69e-01 6.47e-01 0.13800 -0.005170 0.138000 9.69e-01 3.00e-01
Regulation of insulin secretion 47 2.22e-01 3.47e-01 0.13800 -0.132000 0.039600 1.19e-01 6.39e-01
RORA activates gene expression 17 5.58e-01 6.38e-01 0.13700 -0.106000 0.087800 4.50e-01 5.31e-01
PTEN Regulation 128 4.67e-02 1.16e-01 0.13700 0.082200 0.110000 1.09e-01 3.22e-02
Immune System 1225 2.42e-15 1.42e-13 0.13700 -0.024100 0.135000 1.69e-01 1.21e-14
Cellular Senescence 117 6.04e-02 1.40e-01 0.13700 0.075000 0.114000 1.63e-01 3.31e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 48 3.20e-01 4.47e-01 0.13600 0.107000 0.084200 1.99e-01 3.13e-01
Signaling by TGFB family members 86 1.14e-01 2.14e-01 0.13600 0.047000 0.128000 4.52e-01 4.06e-02
Fatty acyl-CoA biosynthesis 18 5.54e-01 6.35e-01 0.13600 -0.062100 0.121000 6.49e-01 3.73e-01
NOTCH1 Intracellular Domain Regulates Transcription 42 2.64e-01 3.92e-01 0.13600 -0.042800 0.129000 6.31e-01 1.47e-01
MAPK1/MAPK3 signaling 193 1.83e-03 9.05e-03 0.13600 -0.071700 0.116000 8.73e-02 5.80e-03
Circadian Clock 63 1.22e-01 2.20e-01 0.13600 -0.092300 0.099800 2.06e-01 1.71e-01
MAP kinase activation 59 1.39e-01 2.45e-01 0.13600 -0.091500 0.101000 2.25e-01 1.82e-01
CDT1 association with the CDC6:ORC:origin complex 48 2.13e-01 3.34e-01 0.13500 0.120000 -0.062900 1.52e-01 4.51e-01
TCR signaling 79 1.48e-01 2.57e-01 0.13500 0.056900 0.122000 3.83e-01 6.08e-02
MyD88 dependent cascade initiated on endosome 77 9.06e-02 1.81e-01 0.13500 -0.048000 0.126000 4.68e-01 5.66e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 77 9.06e-02 1.81e-01 0.13500 -0.048000 0.126000 4.68e-01 5.66e-02
Deactivation of the beta-catenin transactivating complex 32 3.69e-01 4.93e-01 0.13500 -0.044900 0.127000 6.60e-01 2.14e-01
Interleukin-12 signaling 31 4.20e-01 5.36e-01 0.13500 -0.000325 0.135000 9.98e-01 1.95e-01
Switching of origins to a post-replicative state 79 1.16e-01 2.16e-01 0.13400 0.134000 0.004230 3.98e-02 9.48e-01
Loss of Nlp from mitotic centrosomes 60 2.57e-01 3.84e-01 0.13400 0.099900 0.088700 1.81e-01 2.35e-01
Loss of proteins required for interphase microtubule organization from the centrosome 60 2.57e-01 3.84e-01 0.13400 0.099900 0.088700 1.81e-01 2.35e-01
Asparagine N-linked glycosylation 237 3.91e-03 1.69e-02 0.13400 0.055700 0.121000 1.42e-01 1.37e-03
Glutamate Neurotransmitter Release Cycle 12 7.04e-01 7.59e-01 0.13300 -0.024800 0.131000 8.82e-01 4.32e-01
Transcriptional regulation by RUNX1 139 4.43e-02 1.11e-01 0.13300 0.082000 0.105000 9.63e-02 3.34e-02
Oncogene Induced Senescence 29 5.13e-01 5.99e-01 0.13300 0.113000 0.070100 2.92e-01 5.14e-01
Transport to the Golgi and subsequent modification 136 4.48e-02 1.11e-01 0.13300 0.066600 0.115000 1.81e-01 2.11e-02
Selective autophagy 51 2.22e-01 3.47e-01 0.13300 0.033000 -0.129000 6.84e-01 1.12e-01
APC/C:Cdc20 mediated degradation of Securin 59 1.57e-01 2.69e-01 0.13200 0.107000 -0.076800 1.54e-01 3.08e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 76 1.01e-01 1.96e-01 0.13200 -0.051300 0.122000 4.40e-01 6.75e-02
Peptide chain elongation 53 3.06e-01 4.35e-01 0.13100 -0.068600 -0.112000 3.88e-01 1.60e-01
MAPK family signaling cascades 224 1.21e-03 6.27e-03 0.13100 -0.066700 0.113000 8.70e-02 3.88e-03
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 5.52e-01 6.34e-01 0.13100 0.121000 -0.050300 3.50e-01 6.97e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 63 1.53e-01 2.63e-01 0.13000 0.117000 -0.057200 1.08e-01 4.33e-01
TNF signaling 34 3.71e-01 4.93e-01 0.13000 -0.123000 0.043700 2.15e-01 6.60e-01
Termination of translesion DNA synthesis 28 5.47e-01 6.29e-01 0.13000 0.091800 0.092400 4.01e-01 3.98e-01
Constitutive Signaling by EGFRvIII 15 7.01e-01 7.57e-01 0.13000 0.035500 0.125000 8.12e-01 4.02e-01
Signaling by EGFRvIII in Cancer 15 7.01e-01 7.57e-01 0.13000 0.035500 0.125000 8.12e-01 4.02e-01
TP53 Regulates Metabolic Genes 79 1.78e-01 2.93e-01 0.13000 -0.068700 -0.110000 2.92e-01 9.06e-02
Glycosphingolipid metabolism 32 3.81e-01 5.03e-01 0.13000 -0.108000 0.072000 2.92e-01 4.81e-01
Diseases of metabolism 154 1.44e-02 4.79e-02 0.13000 -0.126000 0.028000 6.97e-03 5.50e-01
Mitotic G1 phase and G1/S transition 127 6.94e-02 1.55e-01 0.12900 0.099800 0.081600 5.29e-02 1.13e-01
RAF/MAP kinase cascade 188 4.16e-03 1.78e-02 0.12800 -0.069500 0.108000 1.02e-01 1.10e-02
FOXO-mediated transcription of cell death genes 14 6.97e-01 7.55e-01 0.12800 -0.128000 0.004700 4.06e-01 9.76e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 2.07e-01 3.29e-01 0.12800 -0.089500 0.091500 2.61e-01 2.50e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 62 1.78e-01 2.93e-01 0.12800 0.121000 -0.042000 1.01e-01 5.68e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 1.78e-01 2.93e-01 0.12800 0.121000 -0.042000 1.01e-01 5.68e-01
CDK-mediated phosphorylation and removal of Cdc6 63 1.87e-01 3.04e-01 0.12700 0.125000 -0.024800 8.68e-02 7.34e-01
Downstream TCR signaling 67 2.53e-01 3.80e-01 0.12700 0.086600 0.093100 2.21e-01 1.88e-01
MTOR signalling 40 4.39e-01 5.50e-01 0.12700 -0.079200 -0.099300 3.86e-01 2.78e-01
Ribosomal scanning and start codon recognition 45 3.49e-01 4.76e-01 0.12700 0.125000 0.019200 1.47e-01 8.24e-01
DNA Double Strand Break Response 37 4.62e-01 5.64e-01 0.12600 0.110000 0.061700 2.47e-01 5.16e-01
SARS-CoV Infections 121 5.24e-02 1.26e-01 0.12600 -0.001960 0.126000 9.70e-01 1.71e-02
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.58e-01 5.60e-01 0.12600 -0.125000 0.011000 2.28e-01 9.16e-01
Macroautophagy 98 6.32e-02 1.46e-01 0.12500 0.076300 -0.099300 1.93e-01 9.00e-02
Eukaryotic Translation Termination 55 3.14e-01 4.42e-01 0.12500 -0.048000 -0.115000 5.39e-01 1.39e-01
Interleukin-1 signaling 84 1.64e-01 2.78e-01 0.12500 0.036700 0.119000 5.62e-01 5.95e-02
Signaling by ERBB2 ECD mutants 15 6.63e-01 7.24e-01 0.12500 -0.055300 0.112000 7.11e-01 4.54e-01
Signaling by FGFR4 in disease 11 7.45e-01 7.90e-01 0.12500 -0.042900 0.117000 8.06e-01 5.02e-01
MyD88 cascade initiated on plasma membrane 75 1.26e-01 2.26e-01 0.12400 -0.067600 0.104000 3.12e-01 1.19e-01
Toll Like Receptor 10 (TLR10) Cascade 75 1.26e-01 2.26e-01 0.12400 -0.067600 0.104000 3.12e-01 1.19e-01
Toll Like Receptor 5 (TLR5) Cascade 75 1.26e-01 2.26e-01 0.12400 -0.067600 0.104000 3.12e-01 1.19e-01
Growth hormone receptor signaling 17 6.21e-01 6.94e-01 0.12400 -0.083600 0.091800 5.51e-01 5.13e-01
ABC-family proteins mediated transport 76 1.31e-01 2.34e-01 0.12400 0.050800 -0.113000 4.44e-01 8.94e-02
Processive synthesis on the lagging strand 15 7.21e-01 7.75e-01 0.12400 0.121000 0.026700 4.19e-01 8.58e-01
Cilium Assembly 158 4.06e-02 1.04e-01 0.12300 0.114000 0.047500 1.39e-02 3.05e-01
Budding and maturation of HIV virion 22 6.38e-01 7.06e-01 0.12300 0.047300 0.114000 7.01e-01 3.57e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 24 6.31e-01 7.01e-01 0.12300 0.080700 0.092300 4.94e-01 4.34e-01
Intraflagellar transport 35 4.35e-01 5.47e-01 0.12200 0.122000 -0.011400 2.13e-01 9.07e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 81 1.20e-01 2.18e-01 0.12200 -0.054900 0.109000 3.94e-01 9.03e-02
Toll Like Receptor 2 (TLR2) Cascade 81 1.20e-01 2.18e-01 0.12200 -0.054900 0.109000 3.94e-01 9.03e-02
Toll Like Receptor TLR1:TLR2 Cascade 81 1.20e-01 2.18e-01 0.12200 -0.054900 0.109000 3.94e-01 9.03e-02
Toll Like Receptor TLR6:TLR2 Cascade 81 1.20e-01 2.18e-01 0.12200 -0.054900 0.109000 3.94e-01 9.03e-02
Platelet homeostasis 51 3.08e-01 4.37e-01 0.12200 -0.122000 0.003680 1.33e-01 9.64e-01
Plasma lipoprotein clearance 21 5.80e-01 6.58e-01 0.12200 -0.110000 0.051700 3.83e-01 6.82e-01
Stabilization of p53 48 3.23e-01 4.49e-01 0.12200 0.121000 -0.012200 1.48e-01 8.84e-01
Ub-specific processing proteases 145 6.57e-02 1.51e-01 0.12200 0.098800 0.070700 4.06e-02 1.43e-01
FOXO-mediated transcription 51 3.07e-01 4.36e-01 0.12100 -0.121000 0.007350 1.35e-01 9.28e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 3.92e-01 5.11e-01 0.12100 -0.096300 -0.073400 2.39e-01 3.70e-01
Degradation of beta-catenin by the destruction complex 72 2.51e-01 3.78e-01 0.12100 0.108000 0.054800 1.15e-01 4.23e-01
Repression of WNT target genes 11 8.11e-01 8.49e-01 0.12000 0.057900 0.105000 7.40e-01 5.45e-01
Depolymerisation of the Nuclear Lamina 13 7.87e-01 8.27e-01 0.12000 0.091300 0.078100 5.69e-01 6.26e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 20 6.86e-01 7.46e-01 0.12000 -0.104000 -0.060500 4.22e-01 6.40e-01
Formation of Fibrin Clot (Clotting Cascade) 13 7.86e-01 8.27e-01 0.12000 0.073300 0.095200 6.47e-01 5.52e-01
ER to Golgi Anterograde Transport 114 1.26e-01 2.26e-01 0.12000 0.090800 0.078300 9.51e-02 1.50e-01
Purine catabolism 14 7.43e-01 7.90e-01 0.12000 -0.119000 -0.016000 4.42e-01 9.18e-01
COPI-independent Golgi-to-ER retrograde traffic 27 5.62e-01 6.41e-01 0.12000 0.011800 0.119000 9.15e-01 2.84e-01
Toll Like Receptor 9 (TLR9) Cascade 80 1.53e-01 2.63e-01 0.12000 -0.023600 0.117000 7.16e-01 7.03e-02
CD28 dependent PI3K/Akt signaling 17 6.50e-01 7.17e-01 0.12000 -0.055600 0.106000 6.92e-01 4.50e-01
Regulated proteolysis of p75NTR 11 8.14e-01 8.51e-01 0.11900 0.058300 0.104000 7.38e-01 5.50e-01
Interferon gamma signaling 44 3.29e-01 4.57e-01 0.11900 -0.059700 0.103000 4.94e-01 2.37e-01
Disease 1013 2.76e-09 6.67e-08 0.11900 0.007550 0.119000 6.92e-01 4.46e-10
Translation initiation complex formation 44 3.83e-01 5.05e-01 0.11900 0.119000 -0.001860 1.74e-01 9.83e-01
ROS and RNS production in phagocytes 20 6.19e-01 6.93e-01 0.11900 -0.036600 0.113000 7.77e-01 3.83e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 5.98e-01 6.72e-01 0.11800 -0.077500 -0.089100 4.70e-01 4.07e-01
Orc1 removal from chromatin 59 3.13e-01 4.41e-01 0.11800 0.115000 0.027700 1.28e-01 7.14e-01
Negative regulators of DDX58/IFIH1 signaling 29 5.10e-01 5.96e-01 0.11700 -0.113000 0.032200 2.94e-01 7.64e-01
Signaling by NOTCH3 38 4.29e-01 5.42e-01 0.11700 -0.116000 0.018300 2.18e-01 8.46e-01
Adrenaline,noradrenaline inhibits insulin secretion 17 7.45e-01 7.90e-01 0.11700 -0.082900 -0.082300 5.54e-01 5.57e-01
Deubiquitination 212 2.77e-02 7.78e-02 0.11600 0.084500 0.080000 3.49e-02 4.58e-02
Apoptosis 135 4.33e-02 1.10e-01 0.11600 -0.047500 0.106000 3.43e-01 3.45e-02
Base Excision Repair 43 4.53e-01 5.55e-01 0.11600 0.109000 0.038200 2.15e-01 6.65e-01
Regulation of APC/C activators between G1/S and early anaphase 67 2.20e-01 3.45e-01 0.11500 0.108000 -0.038500 1.26e-01 5.86e-01
Membrane Trafficking 486 4.02e-04 2.42e-03 0.11500 0.070200 0.090600 8.87e-03 7.24e-04
NR1H2 and NR1H3-mediated signaling 34 4.51e-01 5.53e-01 0.11500 -0.098100 0.059100 3.23e-01 5.51e-01
FLT3 Signaling 199 9.85e-03 3.57e-02 0.11400 -0.068700 0.091300 9.63e-02 2.71e-02
Programmed Cell Death 145 3.73e-02 9.84e-02 0.11400 -0.052200 0.101000 2.80e-01 3.60e-02
Diseases of signal transduction by growth factor receptors and second messengers 304 1.68e-03 8.37e-03 0.11400 -0.026400 0.111000 4.33e-01 9.92e-04
Vesicle-mediated transport 508 2.91e-04 1.84e-03 0.11400 0.060600 0.096200 2.09e-02 2.48e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 45 4.09e-01 5.26e-01 0.11300 0.113000 -0.003760 1.91e-01 9.65e-01
Hh mutants abrogate ligand secretion 47 4.01e-01 5.19e-01 0.11300 0.113000 0.002940 1.81e-01 9.72e-01
RA biosynthesis pathway 11 7.78e-01 8.21e-01 0.11200 -0.068000 0.089400 6.96e-01 6.08e-01
SCF(Skp2)-mediated degradation of p27/p21 52 4.11e-01 5.28e-01 0.11100 0.106000 0.035000 1.87e-01 6.62e-01
FGFR1 mutant receptor activation 23 6.43e-01 7.10e-01 0.11100 -0.003790 0.111000 9.75e-01 3.58e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 27 6.44e-01 7.10e-01 0.11000 -0.100000 -0.045600 3.66e-01 6.82e-01
G1/S DNA Damage Checkpoints 57 3.85e-01 5.06e-01 0.11000 0.105000 0.034800 1.72e-01 6.50e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 3.68e-01 4.93e-01 0.11000 0.090700 -0.062200 2.88e-01 4.66e-01
NOTCH3 Intracellular Domain Regulates Transcription 18 6.84e-01 7.45e-01 0.11000 -0.045600 0.099800 7.38e-01 4.64e-01
Processive synthesis on the C-strand of the telomere 19 7.01e-01 7.57e-01 0.10900 0.109000 -0.003370 4.09e-01 9.80e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 26 6.59e-01 7.22e-01 0.10900 0.044500 0.100000 6.95e-01 3.78e-01
Degradation of AXIN 47 4.70e-01 5.69e-01 0.10900 0.101000 0.040800 2.31e-01 6.29e-01
Signaling by NOTCH1 63 2.73e-01 4.00e-01 0.10900 -0.044900 0.098900 5.38e-01 1.75e-01
Regulation of RUNX3 expression and activity 47 4.67e-01 5.67e-01 0.10800 0.104000 0.029800 2.20e-01 7.24e-01
Signaling by Nuclear Receptors 175 7.48e-02 1.64e-01 0.10800 0.058200 0.090600 1.86e-01 3.95e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 4.93e-01 5.84e-01 0.10800 0.096700 0.047300 2.57e-01 5.79e-01
Regulation of PTEN stability and activity 59 3.52e-01 4.79e-01 0.10700 0.107000 0.001910 1.54e-01 9.80e-01
Senescence-Associated Secretory Phenotype (SASP) 45 5.01e-01 5.91e-01 0.10700 0.046200 0.097000 5.92e-01 2.61e-01
Kinesins 24 7.03e-01 7.59e-01 0.10700 0.077000 0.074900 5.14e-01 5.26e-01
Post-translational protein modification 1001 1.35e-06 1.72e-05 0.10700 0.059700 0.089000 1.84e-03 3.38e-06
CD209 (DC-SIGN) signaling 17 7.10e-01 7.64e-01 0.10700 -0.048700 0.094900 7.28e-01 4.98e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 46 4.45e-01 5.52e-01 0.10500 0.104000 -0.012800 2.24e-01 8.81e-01
Formation of the ternary complex, and subsequently, the 43S complex 38 4.92e-01 5.84e-01 0.10400 0.096900 -0.037700 3.02e-01 6.87e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 75 2.33e-01 3.60e-01 0.10400 0.065700 -0.080400 3.26e-01 2.30e-01
Nonsense-Mediated Decay (NMD) 75 2.33e-01 3.60e-01 0.10400 0.065700 -0.080400 3.26e-01 2.30e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 14 8.21e-01 8.56e-01 0.10300 0.047600 0.091700 7.58e-01 5.52e-01
WNT ligand biogenesis and trafficking 12 8.22e-01 8.57e-01 0.10300 -0.103000 -0.002260 5.37e-01 9.89e-01
Disorders of transmembrane transporters 107 2.38e-01 3.65e-01 0.10300 0.067800 0.077600 2.27e-01 1.67e-01
Selenocysteine synthesis 56 4.39e-01 5.50e-01 0.10300 -0.030100 -0.098500 6.97e-01 2.03e-01
Nicotinamide salvaging 12 8.52e-01 8.81e-01 0.10300 -0.069900 -0.075000 6.75e-01 6.53e-01
HDACs deacetylate histones 30 6.56e-01 7.20e-01 0.10200 0.094300 0.038600 3.72e-01 7.14e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 4.90e-01 5.84e-01 0.10200 0.101000 -0.011800 2.52e-01 8.94e-01
p53-Independent DNA Damage Response 43 4.90e-01 5.84e-01 0.10200 0.101000 -0.011800 2.52e-01 8.94e-01
p53-Independent G1/S DNA damage checkpoint 43 4.90e-01 5.84e-01 0.10200 0.101000 -0.011800 2.52e-01 8.94e-01
Autodegradation of Cdh1 by Cdh1:APC/C 58 3.42e-01 4.69e-01 0.10100 0.082100 -0.059500 2.80e-01 4.34e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 55 4.66e-01 5.67e-01 0.10100 0.094600 0.035000 2.26e-01 6.54e-01
VxPx cargo-targeting to cilium 17 7.39e-01 7.88e-01 0.10100 -0.041500 0.091900 7.67e-01 5.12e-01
Glycolysis 55 4.33e-01 5.45e-01 0.10100 0.101000 0.007330 1.98e-01 9.25e-01
Formation of a pool of free 40S subunits 63 3.55e-01 4.81e-01 0.10000 0.016800 -0.099000 8.18e-01 1.75e-01
Transcriptional regulation by RUNX3 86 2.71e-01 3.97e-01 0.10000 0.005620 0.100000 9.28e-01 1.09e-01
Defective CFTR causes cystic fibrosis 50 4.44e-01 5.52e-01 0.10000 0.099400 -0.013500 2.25e-01 8.69e-01
Cytochrome c-mediated apoptotic response 10 8.52e-01 8.81e-01 0.09990 -0.010300 0.099400 9.55e-01 5.86e-01
Signaling by FGFR1 in disease 30 6.42e-01 7.10e-01 0.09990 0.012000 0.099200 9.09e-01 3.47e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 57 4.41e-01 5.51e-01 0.09990 -0.018700 -0.098100 8.08e-01 2.01e-01
Hedgehog ligand biogenesis 50 5.03e-01 5.92e-01 0.09990 0.094900 0.031200 2.46e-01 7.03e-01
Assembly of the pre-replicative complex 56 4.66e-01 5.67e-01 0.09910 0.094900 0.028800 2.20e-01 7.10e-01
Centrosome maturation 71 3.92e-01 5.11e-01 0.09900 0.091400 0.037900 1.84e-01 5.81e-01
Recruitment of mitotic centrosome proteins and complexes 71 3.92e-01 5.11e-01 0.09900 0.091400 0.037900 1.84e-01 5.81e-01
SRP-dependent cotranslational protein targeting to membrane 74 3.03e-01 4.32e-01 0.09900 0.096800 -0.020500 1.51e-01 7.60e-01
Regulation of RAS by GAPs 57 4.77e-01 5.75e-01 0.09900 0.088800 0.043600 2.47e-01 5.70e-01
Metabolism of lipids 494 2.80e-03 1.29e-02 0.09890 -0.067100 -0.072600 1.16e-02 6.34e-03
Regulation of MECP2 expression and activity 26 7.22e-01 7.76e-01 0.09880 -0.078400 -0.060300 4.89e-01 5.95e-01
Autodegradation of the E3 ubiquitin ligase COP1 44 4.84e-01 5.80e-01 0.09880 0.094800 -0.027700 2.77e-01 7.51e-01
Cyclin A:Cdk2-associated events at S phase entry 77 3.54e-01 4.80e-01 0.09850 0.094600 0.027700 1.52e-01 6.75e-01
Insulin processing 19 7.80e-01 8.22e-01 0.09850 0.090200 0.039600 4.96e-01 7.65e-01
Vif-mediated degradation of APOBEC3G 43 4.78e-01 5.75e-01 0.09830 0.085500 -0.048600 3.33e-01 5.82e-01
Cell-cell junction organization 23 6.93e-01 7.53e-01 0.09730 -0.093800 0.025500 4.36e-01 8.32e-01
Regulation of lipid metabolism by PPARalpha 103 2.06e-01 3.28e-01 0.09670 0.094700 -0.019600 9.76e-02 7.31e-01
SARS-CoV-2 Infection 56 4.69e-01 5.69e-01 0.09610 0.013900 0.095100 8.57e-01 2.19e-01
Generic Transcription Pathway 780 9.55e-05 6.89e-04 0.09600 0.091400 0.029100 2.06e-05 1.75e-01
TCF dependent signaling in response to WNT 134 1.92e-01 3.12e-01 0.09530 0.032400 0.089700 5.19e-01 7.41e-02
Resolution of Abasic Sites (AP sites) 36 6.52e-01 7.18e-01 0.09520 0.082900 0.047000 3.90e-01 6.26e-01
p53-Dependent G1 DNA Damage Response 56 4.93e-01 5.84e-01 0.09450 0.091700 0.022700 2.36e-01 7.69e-01
p53-Dependent G1/S DNA damage checkpoint 56 4.93e-01 5.84e-01 0.09450 0.091700 0.022700 2.36e-01 7.69e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 36 6.53e-01 7.18e-01 0.09430 0.085300 0.040200 3.76e-01 6.77e-01
Regulation of Apoptosis 45 4.89e-01 5.84e-01 0.09420 0.078200 -0.052400 3.64e-01 5.43e-01
Vpu mediated degradation of CD4 43 5.12e-01 5.98e-01 0.09350 0.081000 -0.046700 3.59e-01 5.96e-01
Glutathione synthesis and recycling 10 8.53e-01 8.82e-01 0.09340 -0.061800 0.069900 7.35e-01 7.02e-01
Cellular responses to external stimuli 410 1.32e-02 4.47e-02 0.09190 0.049900 0.077200 8.62e-02 7.94e-03
Negative regulation of MAPK pathway 39 6.60e-01 7.23e-01 0.09140 0.057900 0.070800 5.32e-01 4.45e-01
Tight junction interactions 11 8.47e-01 8.78e-01 0.09110 0.071900 -0.055900 6.80e-01 7.48e-01
PPARA activates gene expression 101 2.48e-01 3.76e-01 0.09070 0.087100 -0.025300 1.31e-01 6.62e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 7.92e-01 8.32e-01 0.09030 -0.006640 0.090100 9.61e-01 5.09e-01
Metabolism of polyamines 50 5.44e-01 6.27e-01 0.09000 0.089700 0.006350 2.73e-01 9.38e-01
Cellular responses to stress 406 1.66e-02 5.30e-02 0.08990 0.049000 0.075400 9.36e-02 9.90e-03
NRIF signals cell death from the nucleus 13 8.73e-01 8.96e-01 0.08970 0.075400 0.048500 6.38e-01 7.62e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 73 3.51e-01 4.78e-01 0.08970 0.076100 -0.047400 2.62e-01 4.85e-01
G-protein beta:gamma signalling 20 8.12e-01 8.49e-01 0.08950 -0.076400 -0.046500 5.54e-01 7.19e-01
Dectin-1 mediated noncanonical NF-kB signaling 51 5.76e-01 6.54e-01 0.08880 0.083900 0.029200 3.01e-01 7.19e-01
Recruitment of NuMA to mitotic centrosomes 70 4.91e-01 5.84e-01 0.08870 0.075000 0.047200 2.78e-01 4.95e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 55 4.79e-01 5.76e-01 0.08810 0.031600 -0.082200 6.86e-01 2.92e-01
Cyclin E associated events during G1/S transition 75 4.29e-01 5.42e-01 0.08760 0.086900 0.010800 1.94e-01 8.72e-01
Ubiquitin-dependent degradation of Cyclin D 44 6.07e-01 6.80e-01 0.08740 0.086900 0.009040 3.19e-01 9.17e-01
Regulation of RUNX2 expression and activity 61 4.41e-01 5.51e-01 0.08720 0.041100 -0.076900 5.79e-01 3.00e-01
Glucose metabolism 69 4.80e-01 5.77e-01 0.08720 -0.023400 -0.084000 7.38e-01 2.28e-01
Fc epsilon receptor (FCERI) signaling 104 3.20e-01 4.47e-01 0.08720 0.015100 0.085900 7.91e-01 1.31e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 11 9.01e-01 9.19e-01 0.08640 0.059300 0.062900 7.34e-01 7.18e-01
Signaling by NOTCH 149 1.38e-01 2.44e-01 0.08600 -0.063900 0.057600 1.79e-01 2.27e-01
Nuclear signaling by ERBB4 20 7.68e-01 8.11e-01 0.08580 -0.072800 0.045400 5.73e-01 7.25e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 6.22e-01 6.94e-01 0.08480 0.084600 -0.004810 3.43e-01 9.57e-01
Cap-dependent Translation Initiation 79 3.63e-01 4.88e-01 0.08450 0.068100 -0.050000 2.96e-01 4.44e-01
Eukaryotic Translation Initiation 79 3.63e-01 4.88e-01 0.08450 0.068100 -0.050000 2.96e-01 4.44e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 66 4.45e-01 5.52e-01 0.08360 -0.037900 0.074500 5.95e-01 2.96e-01
COPI-mediated anterograde transport 73 5.01e-01 5.91e-01 0.08330 0.027800 0.078500 6.82e-01 2.47e-01
Amino acids regulate mTORC1 45 5.75e-01 6.53e-01 0.08290 -0.044700 0.069900 6.04e-01 4.18e-01
Hedgehog 'on' state 71 5.36e-01 6.20e-01 0.08290 0.048200 0.067400 4.84e-01 3.27e-01
Downregulation of ERBB2 signaling 18 8.10e-01 8.48e-01 0.08270 -0.027100 0.078200 8.43e-01 5.66e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 7.43e-01 7.90e-01 0.08260 -0.064100 0.052100 5.87e-01 6.59e-01
Metabolism of proteins 1402 1.03e-05 9.03e-05 0.08240 0.078400 0.025200 2.12e-06 1.28e-01
ERKs are inactivated 13 8.66e-01 8.90e-01 0.08240 -0.081400 0.012500 6.12e-01 9.38e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 35 7.32e-01 7.83e-01 0.08170 0.074300 0.034100 4.47e-01 7.27e-01
Diseases of mitotic cell cycle 35 7.32e-01 7.83e-01 0.08170 0.074300 0.034100 4.47e-01 7.27e-01
L13a-mediated translational silencing of Ceruloplasmin expression 71 4.25e-01 5.39e-01 0.08160 0.059200 -0.056200 3.90e-01 4.13e-01
UCH proteinases 74 5.26e-01 6.11e-01 0.08140 0.071700 0.038700 2.87e-01 5.66e-01
Cellular response to hypoxia 62 4.91e-01 5.84e-01 0.08090 0.034500 -0.073200 6.39e-01 3.19e-01
CLEC7A (Dectin-1) signaling 80 4.22e-01 5.38e-01 0.08060 -0.018200 0.078600 7.78e-01 2.25e-01
Organelle biogenesis and maintenance 224 7.58e-02 1.65e-01 0.08040 0.059500 -0.054100 1.27e-01 1.66e-01
RHO GTPases Activate NADPH Oxidases 13 8.63e-01 8.88e-01 0.07910 -0.059500 0.052100 7.10e-01 7.45e-01
NIK-->noncanonical NF-kB signaling 50 6.37e-01 7.06e-01 0.07890 0.077700 0.013700 3.42e-01 8.67e-01
Regulation of expression of SLITs and ROBOs 114 3.03e-01 4.32e-01 0.07850 0.025900 -0.074100 6.33e-01 1.73e-01
Transcriptional regulation by RUNX2 99 3.89e-01 5.10e-01 0.07850 -0.002400 0.078400 9.67e-01 1.79e-01
Activation of NF-kappaB in B cells 56 6.44e-01 7.10e-01 0.07840 0.062800 0.047000 4.17e-01 5.43e-01
Transferrin endocytosis and recycling 21 7.94e-01 8.34e-01 0.07800 0.044400 -0.064100 7.25e-01 6.11e-01
Cleavage of the damaged pyrimidine 14 8.57e-01 8.83e-01 0.07790 0.053600 -0.056600 7.29e-01 7.14e-01
Depyrimidination 14 8.57e-01 8.83e-01 0.07790 0.053600 -0.056600 7.29e-01 7.14e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 8.57e-01 8.83e-01 0.07790 0.053600 -0.056600 7.29e-01 7.14e-01
TNFR2 non-canonical NF-kB pathway 63 5.22e-01 6.08e-01 0.07790 -0.024300 0.074000 7.39e-01 3.10e-01
Cleavage of the damaged purine 10 9.18e-01 9.33e-01 0.07730 0.075700 0.016000 6.79e-01 9.30e-01
Depurination 10 9.18e-01 9.33e-01 0.07730 0.075700 0.016000 6.79e-01 9.30e-01
Recognition and association of DNA glycosylase with site containing an affected purine 10 9.18e-01 9.33e-01 0.07730 0.075700 0.016000 6.79e-01 9.30e-01
G beta:gamma signalling through PI3Kgamma 15 8.92e-01 9.14e-01 0.07700 -0.062000 -0.045700 6.78e-01 7.59e-01
mTORC1-mediated signalling 23 8.27e-01 8.60e-01 0.07690 -0.021700 -0.073800 8.57e-01 5.40e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 50 5.94e-01 6.69e-01 0.07680 -0.067900 0.035700 4.07e-01 6.63e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 50 5.94e-01 6.69e-01 0.07680 -0.067900 0.035700 4.07e-01 6.63e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 50 5.94e-01 6.69e-01 0.07680 -0.067900 0.035700 4.07e-01 6.63e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 50 5.94e-01 6.69e-01 0.07680 -0.067900 0.035700 4.07e-01 6.63e-01
Signaling by NOTCH1 in Cancer 50 5.94e-01 6.69e-01 0.07680 -0.067900 0.035700 4.07e-01 6.63e-01
Metabolism of steroids 93 3.91e-01 5.11e-01 0.07670 -0.071600 0.027600 2.34e-01 6.46e-01
Degradation of GLI1 by the proteasome 51 5.91e-01 6.68e-01 0.07580 0.062000 -0.043500 4.44e-01 5.91e-01
Signaling by WNT 202 2.01e-01 3.22e-01 0.07490 0.014600 0.073400 7.22e-01 7.34e-02
Peptide hormone metabolism 39 7.28e-01 7.81e-01 0.07450 0.011200 0.073700 9.04e-01 4.26e-01
Transcriptional Regulation by VENTX 34 7.31e-01 7.83e-01 0.07440 0.072400 -0.017300 4.65e-01 8.61e-01
Rab regulation of trafficking 110 4.37e-01 5.49e-01 0.07360 0.020500 0.070700 7.11e-01 2.01e-01
SCF-beta-TrCP mediated degradation of Emi1 45 6.62e-01 7.24e-01 0.07170 0.061700 -0.036700 4.75e-01 6.71e-01
ABC transporter disorders 56 6.07e-01 6.80e-01 0.07090 0.034800 -0.061800 6.52e-01 4.25e-01
Regulation of ornithine decarboxylase (ODC) 44 6.95e-01 7.54e-01 0.07020 0.067700 -0.018300 4.37e-01 8.33e-01
TP53 Regulates Transcription of Cell Death Genes 34 7.60e-01 8.04e-01 0.06950 -0.067400 0.017000 4.97e-01 8.64e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 23 8.70e-01 8.93e-01 0.06900 0.045800 0.051600 7.04e-01 6.69e-01
Autophagy 108 3.96e-01 5.14e-01 0.06900 0.047100 -0.050300 3.99e-01 3.67e-01
C-type lectin receptors (CLRs) 94 4.83e-01 5.79e-01 0.06830 -0.016700 0.066200 7.81e-01 2.68e-01
Adaptive Immune System 477 5.53e-02 1.31e-01 0.06820 0.024200 0.063800 3.72e-01 1.84e-02
ADP signalling through P2Y purinoceptor 12 13 8.97e-01 9.17e-01 0.06780 0.048300 -0.047500 7.63e-01 7.67e-01
G-protein activation 13 8.97e-01 9.17e-01 0.06780 0.048300 -0.047500 7.63e-01 7.67e-01
Insulin receptor recycling 17 8.99e-01 9.19e-01 0.06680 0.018100 0.064300 8.97e-01 6.47e-01
Maturation of nucleoprotein 10 9.37e-01 9.48e-01 0.06600 -0.005810 -0.065700 9.75e-01 7.19e-01
Endogenous sterols 13 9.32e-01 9.44e-01 0.06490 -0.054300 -0.035400 7.35e-01 8.25e-01
Activated NOTCH1 Transmits Signal to the Nucleus 24 8.34e-01 8.66e-01 0.06480 -0.051300 0.039600 6.64e-01 7.37e-01
Thromboxane signalling through TP receptor 14 9.27e-01 9.40e-01 0.06420 0.055100 0.032900 7.21e-01 8.31e-01
ER-Phagosome pathway 61 6.91e-01 7.51e-01 0.06390 0.063600 0.006460 3.91e-01 9.31e-01
Antigen processing-Cross presentation 69 7.10e-01 7.64e-01 0.06240 0.048600 0.039100 4.86e-01 5.75e-01
Cross-presentation of soluble exogenous antigens (endosomes) 40 7.68e-01 8.11e-01 0.06190 0.058000 -0.021700 5.26e-01 8.12e-01
GLI3 is processed to GLI3R by the proteasome 50 7.39e-01 7.88e-01 0.05820 0.049000 -0.031400 5.50e-01 7.02e-01
Signaling by ERBB4 37 8.38e-01 8.69e-01 0.05750 0.010700 0.056500 9.10e-01 5.52e-01
Iron uptake and transport 43 8.36e-01 8.68e-01 0.05630 -0.049400 -0.027000 5.76e-01 7.60e-01
RAB GEFs exchange GTP for GDP on RABs 81 7.25e-01 7.78e-01 0.05580 0.033700 0.044500 6.01e-01 4.90e-01
Phospholipid metabolism 150 5.59e-01 6.39e-01 0.05560 -0.038400 -0.040200 4.19e-01 3.98e-01
Asymmetric localization of PCP proteins 55 7.41e-01 7.90e-01 0.05500 0.044200 -0.032800 5.72e-01 6.75e-01
Signaling by the B Cell Receptor (BCR) 85 6.79e-01 7.40e-01 0.05460 0.000958 0.054600 9.88e-01 3.85e-01
FCERI mediated NF-kB activation 65 7.79e-01 8.22e-01 0.05460 0.045300 0.030500 5.29e-01 6.71e-01
Base-Excision Repair, AP Site Formation 16 9.19e-01 9.33e-01 0.05410 0.030900 -0.044500 8.31e-01 7.58e-01
Selenoamino acid metabolism 68 7.84e-01 8.26e-01 0.05060 -0.013500 -0.048700 8.48e-01 4.88e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 63 8.15e-01 8.51e-01 0.05050 -0.031200 -0.039700 6.69e-01 5.86e-01
Disorders of Developmental Biology 10 9.71e-01 9.75e-01 0.04730 -0.041200 -0.023100 8.21e-01 8.99e-01
Disorders of Nervous System Development 10 9.71e-01 9.75e-01 0.04730 -0.041200 -0.023100 8.21e-01 8.99e-01
Loss of function of MECP2 in Rett syndrome 10 9.71e-01 9.75e-01 0.04730 -0.041200 -0.023100 8.21e-01 8.99e-01
Pervasive developmental disorders 10 9.71e-01 9.75e-01 0.04730 -0.041200 -0.023100 8.21e-01 8.99e-01
MAPK6/MAPK4 signaling 73 8.25e-01 8.59e-01 0.04560 0.034600 0.029800 6.10e-01 6.60e-01
Degradation of GLI2 by the proteasome 50 8.32e-01 8.65e-01 0.04510 0.030400 -0.033300 7.10e-01 6.84e-01
Signaling by Hedgehog 114 7.33e-01 7.84e-01 0.04290 0.004180 0.042700 9.39e-01 4.33e-01
Negative regulation of NOTCH4 signaling 47 8.64e-01 8.89e-01 0.04250 0.039400 -0.015800 6.41e-01 8.51e-01
Degradation of DVL 48 8.65e-01 8.90e-01 0.04170 0.016200 -0.038400 8.46e-01 6.46e-01
Neddylation 200 6.26e-01 6.96e-01 0.04020 -0.005470 -0.039800 8.94e-01 3.34e-01
Ca2+ pathway 45 9.17e-01 9.33e-01 0.03880 -0.022700 -0.031400 7.92e-01 7.16e-01
ADP signalling through P2Y purinoceptor 1 15 9.67e-01 9.74e-01 0.03710 -0.036500 0.006950 8.07e-01 9.63e-01
Diseases associated with glycosylation precursor biosynthesis 18 9.67e-01 9.74e-01 0.03590 0.035100 0.007180 7.96e-01 9.58e-01
Downstream signaling events of B Cell Receptor (BCR) 67 8.80e-01 9.02e-01 0.03360 -0.009050 0.032400 8.98e-01 6.47e-01
Class I MHC mediated antigen processing & presentation 303 6.54e-01 7.19e-01 0.03210 0.030800 0.009310 3.61e-01 7.82e-01
Signaling by NOTCH2 24 9.61e-01 9.71e-01 0.03040 -0.026100 0.015600 8.25e-01 8.95e-01
Signaling by NOTCH4 70 9.25e-01 9.39e-01 0.02930 0.025100 0.015100 7.17e-01 8.28e-01
SARS-CoV-1 Infection 40 9.66e-01 9.74e-01 0.02590 -0.022000 -0.013600 8.10e-01 8.82e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 29 9.77e-01 9.80e-01 0.02460 0.021200 0.012600 8.44e-01 9.06e-01
Antigen processing: Ubiquitination & Proteasome degradation 265 8.04e-01 8.43e-01 0.02160 0.017600 -0.012500 6.24e-01 7.28e-01
Signaling by ROBO receptors 151 9.06e-01 9.24e-01 0.02150 -0.021000 -0.004770 6.58e-01 9.20e-01
Hedgehog 'off' state 87 9.48e-01 9.59e-01 0.02120 0.020000 0.006920 7.47e-01 9.11e-01
RAF activation 34 9.82e-01 9.84e-01 0.02070 -0.016700 -0.012200 8.66e-01 9.02e-01
Synthesis of pyrophosphates in the cytosol 10 9.93e-01 9.94e-01 0.01970 0.007670 -0.018200 9.67e-01 9.21e-01
PCP/CE pathway 79 9.50e-01 9.60e-01 0.01900 -0.013200 0.013600 8.39e-01 8.34e-01
Signaling by cytosolic FGFR1 fusion mutants 17 9.95e-01 9.95e-01 0.01370 -0.003780 0.013200 9.79e-01 9.25e-01
Beta-catenin independent WNT signaling 117 9.88e-01 9.89e-01 0.00825 -0.008240 0.000487 8.78e-01 9.93e-01


Detailed Gene set reports


Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
metric value
setSize 21
pMANOVA 1.45e-09
p.adjustMANOVA 3.64e-08
s.dist 0.833
s.human -0.243
s.mouse -0.797
p.human 0.0539
p.mouse 2.5e-10




Top 20 genes
Gene human mouse
IDH2 -5216 -4835
SDHA -4773 -4748
OGDH -5268 -4106
MDH2 -4361 -4332
ACO2 -3822 -4534
SDHC -3712 -4323
IDH3G -4178 -3714
NNT -3325 -4200
IDH3B -2881 -4194
IDH3A -2155 -4265
FAHD1 -1771 -4836
SUCLG2 -1167 -4765
DLST -323 -4762
SUCLG1 -31 -4434

Click HERE to show all gene set members

All member genes
human mouse
ACO2 -3822 -4534
CS 3653 -4328
DLD 1187 -4834
DLST -323 -4762
FAHD1 -1771 -4836
FH 287 -4146
IDH2 -5216 -4835
IDH3A -2155 -4265
IDH3B -2881 -4194
IDH3G -4178 -3714
MDH2 -4361 -4332
ME2 -1789 3649
ME3 4207 -3631
NNT -3325 -4200
OGDH -5268 -4106
SDHA -4773 -4748
SDHB 431 -4408
SDHC -3712 -4323
SUCLA2 1517 -4804
SUCLG1 -31 -4434
SUCLG2 -1167 -4765



Mitochondrial Fatty Acid Beta-Oxidation

Mitochondrial Fatty Acid Beta-Oxidation
metric value
setSize 30
pMANOVA 2.13e-11
p.adjustMANOVA 7.5e-10
s.dist 0.783
s.human -0.336
s.mouse -0.708
p.human 0.00148
p.mouse 1.94e-11




Top 20 genes
Gene human mouse
ACOT11 -5260 -4722.0
ACADVL -4952 -4770.0
ACAD10 -4565 -4492.0
ACADS -4663 -4266.0
ECHS1 -3895 -4648.0
ECI1 -3975 -4524.0
ACOT2 -2912 -4940.5
HADHA -3202 -4418.0
HADH -2786 -5075.0
ACOT13 -2994 -4635.0
DECR1 -2617 -4927.0
PCCA -2597 -4409.0
ACAA2 -2330 -4889.0
THEM4 -3616 -2987.0
MECR -3190 -3135.0
HADHB -2035 -4747.0
ACADM -1714 -4943.0
ACADL -1021 -4991.0
MCEE -816 -4855.0
MCAT -628 -4342.0

Click HERE to show all gene set members

All member genes
human mouse
ACAA2 -2330 -4889.0
ACAD10 -4565 -4492.0
ACAD11 421 -5042.0
ACADL -1021 -4991.0
ACADM -1714 -4943.0
ACADS -4663 -4266.0
ACADVL -4952 -4770.0
ACOT1 1587 -4940.5
ACOT11 -5260 -4722.0
ACOT13 -2994 -4635.0
ACOT2 -2912 -4940.5
ACOT7 -716 4137.0
ACOT9 478 5113.0
ACSF2 -5148 1368.0
DBI -2859 -619.0
DECR1 -2617 -4927.0
ECHS1 -3895 -4648.0
ECI1 -3975 -4524.0
HADH -2786 -5075.0
HADHA -3202 -4418.0
HADHB -2035 -4747.0
MCAT -628 -4342.0
MCEE -816 -4855.0
MECR -3190 -3135.0
MMAA 2798 -4294.0
NDUFAB1 1151 -3286.0
PCCA -2597 -4409.0
PCCB -165 -4900.0
PCTP -322 -3225.0
THEM4 -3616 -2987.0



Complex I biogenesis

Complex I biogenesis
metric value
setSize 52
pMANOVA 2.28e-19
p.adjustMANOVA 1.65e-17
s.dist 0.765
s.human -0.196
s.mouse -0.739
p.human 0.0145
p.mouse 2.74e-20




Top 20 genes
Gene human mouse
ACAD9 -4578 -4327
NDUFB7 -4222 -4592
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
NDUFB8 -3020 -4892
NDUFA3 -3805 -3788
NDUFB10 -3373 -4176
NDUFS3 -3567 -3762
NDUFAF3 -3581 -3648
MT-ND5 -3244 -3936
NDUFB2 -3732 -3330
NDUFS2 -3026 -4010
NDUFV3 -2378 -4769
NDUFA9 -2868 -3934
NDUFAF6 -2555 -4169
ECSIT -2655 -4003
NDUFA13 -2253 -4458
NDUFB11 -2103 -4410
NDUFA10 -1955 -4567

Click HERE to show all gene set members

All member genes
human mouse
ACAD9 -4578 -4327
ECSIT -2655 -4003
MT-ND1 -353 -4097
MT-ND2 -1120 -4098
MT-ND4 -2086 -3521
MT-ND5 -3244 -3936
MT-ND6 816 -5003
NDUFA1 -737 -4064
NDUFA10 -1955 -4567
NDUFA11 -1033 -3018
NDUFA12 -1315 -3437
NDUFA13 -2253 -4458
NDUFA2 -1290 -3394
NDUFA3 -3805 -3788
NDUFA5 534 -4100
NDUFA6 -77 -4563
NDUFA7 -465 -4072
NDUFA8 -602 -3874
NDUFA9 -2868 -3934
NDUFAB1 1151 -3286
NDUFAF1 1175 -4667
NDUFAF2 3504 -3035
NDUFAF3 -3581 -3648
NDUFAF4 3740 -1490
NDUFAF5 29 -2432
NDUFAF6 -2555 -4169
NDUFAF7 2971 -1191
NDUFB10 -3373 -4176
NDUFB11 -2103 -4410
NDUFB2 -3732 -3330
NDUFB3 852 -4452
NDUFB4 -311 -2945
NDUFB5 -2039 -3251
NDUFB6 928 -2670
NDUFB7 -4222 -4592
NDUFB8 -3020 -4892
NDUFB9 -996 -4847
NDUFC1 -664 -3623
NDUFC2 34 -4249
NDUFS1 -1544 -4861
NDUFS2 -3026 -4010
NDUFS3 -3567 -3762
NDUFS4 -1690 -4308
NDUFS5 -1235 -4521
NDUFS6 -1332 -4239
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
NDUFV3 -2378 -4769
NUBPL -1541 -1280
TIMMDC1 213 -2918
TMEM126B 1024 1865



Respiratory electron transport

Respiratory electron transport
metric value
setSize 92
pMANOVA 1.87e-31
p.adjustMANOVA 5.78e-29
s.dist 0.737
s.human -0.178
s.mouse -0.715
p.human 0.0033
p.mouse 1.81e-32




Top 20 genes
Gene human mouse
SDHA -4773 -4748
ACAD9 -4578 -4327
NDUFB7 -4222 -4592
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
CYC1 -4147 -4292
SDHC -3712 -4323
COX8A -4337 -3691
TRAP1 -5265 -2862
NDUFB8 -3020 -4892
UQCRC1 -3333 -4403
NDUFA3 -3805 -3788
NDUFB10 -3373 -4176
MT-CO1 -3167 -4401
COQ10A -3553 -3807
NDUFS3 -3567 -3762
NDUFAF3 -3581 -3648
COX14 -2772 -4676
MT-ND5 -3244 -3936

Click HERE to show all gene set members

All member genes
human mouse
ACAD9 -4578 -4327
COQ10A -3553 -3807
COQ10B 4344 1577
COX11 -2860 -2700
COX14 -2772 -4676
COX16 -2259 -2674
COX18 -554 -2459
COX19 3053 2889
COX20 1104 -3676
COX4I1 -2357 -3606
COX5A -2511 -4214
COX5B -2559 -4822
COX6A1 2259 -1583
COX6B1 -2231 -3407
COX6C -18 -3754
COX7B 144 -2853
COX7C -1495 -3356
COX8A -4337 -3691
CYC1 -4147 -4292
ECSIT -2655 -4003
ETFA 3160 -4491
ETFB -3614 -1903
ETFDH 1884 -4980
LRPPRC 1656 -4711
MT-CO1 -3167 -4401
MT-CYB -1355 -4115
MT-ND1 -353 -4097
MT-ND2 -1120 -4098
MT-ND4 -2086 -3521
MT-ND5 -3244 -3936
MT-ND6 816 -5003
NDUFA1 -737 -4064
NDUFA10 -1955 -4567
NDUFA11 -1033 -3018
NDUFA12 -1315 -3437
NDUFA13 -2253 -4458
NDUFA2 -1290 -3394
NDUFA3 -3805 -3788
NDUFA4 -393 -2605
NDUFA5 534 -4100
NDUFA6 -77 -4563
NDUFA7 -465 -4072
NDUFA8 -602 -3874
NDUFA9 -2868 -3934
NDUFAB1 1151 -3286
NDUFAF1 1175 -4667
NDUFAF2 3504 -3035
NDUFAF3 -3581 -3648
NDUFAF4 3740 -1490
NDUFAF5 29 -2432
NDUFAF6 -2555 -4169
NDUFAF7 2971 -1191
NDUFB10 -3373 -4176
NDUFB11 -2103 -4410
NDUFB2 -3732 -3330
NDUFB3 852 -4452
NDUFB4 -311 -2945
NDUFB5 -2039 -3251
NDUFB6 928 -2670
NDUFB7 -4222 -4592
NDUFB8 -3020 -4892
NDUFB9 -996 -4847
NDUFC1 -664 -3623
NDUFC2 34 -4249
NDUFS1 -1544 -4861
NDUFS2 -3026 -4010
NDUFS3 -3567 -3762
NDUFS4 -1690 -4308
NDUFS5 -1235 -4521
NDUFS6 -1332 -4239
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
NDUFV3 -2378 -4769
NUBPL -1541 -1280
SCO1 3577 -27
SCO2 -1941 -3526
SDHA -4773 -4748
SDHB 431 -4408
SDHC -3712 -4323
SURF1 -1748 -3290
TACO1 651 -4903
TIMMDC1 213 -2918
TMEM126B 1024 1865
TRAP1 -5265 -2862
UQCR10 -3139 -3068
UQCRB 403 -4257
UQCRC1 -3333 -4403
UQCRC2 551 -4650
UQCRFS1 -151 -4321
UQCRH -1532 -4546
UQCRQ -1767 -3443



Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
metric value
setSize 49
pMANOVA 4.72e-16
p.adjustMANOVA 2.91e-14
s.dist 0.727
s.human -0.263
s.mouse -0.678
p.human 0.00145
p.mouse 2.15e-16




Top 20 genes
Gene human mouse
IDH2 -5216 -4835
D2HGDH -4890 -5104
PDK2 -5450 -4464
SDHA -4773 -4748
OGDH -5268 -4106
SLC16A3 -4751 -4193
MDH2 -4361 -4332
ACO2 -3822 -4534
MPC1 -3681 -4360
SDHC -3712 -4323
IDH3G -4178 -3714
NNT -3325 -4200
VDAC1 -2909 -4782
ADHFE1 -4039 -3168
HAGH -4509 -2740
IDH3B -2881 -4194
PDHA1 -2405 -4692
GSTZ1 -2068 -5077
LDHA -3251 -3213
IDH3A -2155 -4265

Click HERE to show all gene set members

All member genes
human mouse
ACO2 -3822 -4534
ADHFE1 -4039 -3168
BSG -2248 -3662
CS 3653 -4328
D2HGDH -4890 -5104
DLAT -1960 -4426
DLD 1187 -4834
DLST -323 -4762
FAHD1 -1771 -4836
FH 287 -4146
GLO1 -678 -4289
GSTZ1 -2068 -5077
HAGH -4509 -2740
IDH2 -5216 -4835
IDH3A -2155 -4265
IDH3B -2881 -4194
IDH3G -4178 -3714
L2HGDH -262 -2260
LDHA -3251 -3213
LDHB -1491 -4379
MDH2 -4361 -4332
ME1 1789 -534
ME2 -1789 3649
ME3 4207 -3631
MPC1 -3681 -4360
MPC2 829 -3712
NNT -3325 -4200
OGDH -5268 -4106
PDHA1 -2405 -4692
PDHB -133 -4587
PDHX -126 -4448
PDK1 4600 -3535
PDK2 -5450 -4464
PDK3 4747 5315
PDK4 -712 -4300
PDP1 -2175 -3641
PDP2 -2619 -3350
PDPR -632 -3822
PPARD -4213 2330
RXRA -5519 1619
SDHA -4773 -4748
SDHB 431 -4408
SDHC -3712 -4323
SLC16A1 -987 2280
SLC16A3 -4751 -4193
SUCLA2 1517 -4804
SUCLG1 -31 -4434
SUCLG2 -1167 -4765
VDAC1 -2909 -4782



Interleukin-10 signaling

Interleukin-10 signaling
metric value
setSize 11
pMANOVA 4.62e-05
p.adjustMANOVA 0.000356
s.dist 0.725
s.human -0.252
s.mouse 0.68
p.human 0.148
p.mouse 9.46e-05




Top 20 genes
Gene human mouse
CSF1 -4242 4888
STAT3 -3885 5276
TNFRSF1A -4666 3341
IL1R1 -3018 4729
JAK1 -1869 4962
TIMP1 -1317 5467
TNFRSF1B -874 4531
TYK2 -3123 725

Click HERE to show all gene set members

All member genes
human mouse
CCL2 2620 5213
CSF1 -4242 4888
ICAM1 1056 41
IL10RB 1239 2957
IL1R1 -3018 4729
JAK1 -1869 4962
STAT3 -3885 5276
TIMP1 -1317 5467
TNFRSF1A -4666 3341
TNFRSF1B -874 4531
TYK2 -3123 725



The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport
metric value
setSize 142
pMANOVA 4.45e-45
p.adjustMANOVA 2.75e-42
s.dist 0.718
s.human -0.202
s.mouse -0.689
p.human 3.49e-05
p.mouse 1.02e-45




Top 20 genes
Gene human mouse
IDH2 -5216 -4835
D2HGDH -4890 -5104
PDK2 -5450 -4464
SDHA -4773 -4748
OGDH -5268 -4106
SLC16A3 -4751 -4193
ACAD9 -4578 -4327
NDUFB7 -4222 -4592
MDH2 -4361 -4332
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
CYC1 -4147 -4292
ACO2 -3822 -4534
MPC1 -3681 -4360
SDHC -3712 -4323
COX8A -4337 -3691
IDH3G -4178 -3714
TRAP1 -5265 -2862
NDUFB8 -3020 -4892

Click HERE to show all gene set members

All member genes
human mouse
ACAD9 -4578 -4327
ACO2 -3822 -4534
ADHFE1 -4039 -3168
BSG -2248 -3662
COQ10A -3553 -3807
COQ10B 4344 1577
COX11 -2860 -2700
COX14 -2772 -4676
COX16 -2259 -2674
COX18 -554 -2459
COX19 3053 2889
COX20 1104 -3676
COX4I1 -2357 -3606
COX5A -2511 -4214
COX5B -2559 -4822
COX6A1 2259 -1583
COX6B1 -2231 -3407
COX6C -18 -3754
COX7B 144 -2853
COX7C -1495 -3356
COX8A -4337 -3691
CS 3653 -4328
CYC1 -4147 -4292
D2HGDH -4890 -5104
DLAT -1960 -4426
DLD 1187 -4834
DLST -323 -4762
ECSIT -2655 -4003
ETFA 3160 -4491
ETFB -3614 -1903
ETFDH 1884 -4980
FAHD1 -1771 -4836
FH 287 -4146
GLO1 -678 -4289
GSTZ1 -2068 -5077
HAGH -4509 -2740
IDH2 -5216 -4835
IDH3A -2155 -4265
IDH3B -2881 -4194
IDH3G -4178 -3714
L2HGDH -262 -2260
LDHA -3251 -3213
LDHB -1491 -4379
LRPPRC 1656 -4711
MDH2 -4361 -4332
ME1 1789 -534
ME2 -1789 3649
ME3 4207 -3631
MPC1 -3681 -4360
MPC2 829 -3712
MT-CO1 -3167 -4401
MT-CYB -1355 -4115
MT-ND1 -353 -4097
MT-ND2 -1120 -4098
MT-ND4 -2086 -3521
MT-ND5 -3244 -3936
MT-ND6 816 -5003
NDUFA1 -737 -4064
NDUFA10 -1955 -4567
NDUFA11 -1033 -3018
NDUFA12 -1315 -3437
NDUFA13 -2253 -4458
NDUFA2 -1290 -3394
NDUFA3 -3805 -3788
NDUFA4 -393 -2605
NDUFA5 534 -4100
NDUFA6 -77 -4563
NDUFA7 -465 -4072
NDUFA8 -602 -3874
NDUFA9 -2868 -3934
NDUFAB1 1151 -3286
NDUFAF1 1175 -4667
NDUFAF2 3504 -3035
NDUFAF3 -3581 -3648
NDUFAF4 3740 -1490
NDUFAF5 29 -2432
NDUFAF6 -2555 -4169
NDUFAF7 2971 -1191
NDUFB10 -3373 -4176
NDUFB11 -2103 -4410
NDUFB2 -3732 -3330
NDUFB3 852 -4452
NDUFB4 -311 -2945
NDUFB5 -2039 -3251
NDUFB6 928 -2670
NDUFB7 -4222 -4592
NDUFB8 -3020 -4892
NDUFB9 -996 -4847
NDUFC1 -664 -3623
NDUFC2 34 -4249
NDUFS1 -1544 -4861
NDUFS2 -3026 -4010
NDUFS3 -3567 -3762
NDUFS4 -1690 -4308
NDUFS5 -1235 -4521
NDUFS6 -1332 -4239
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
NDUFV3 -2378 -4769
NNT -3325 -4200
NUBPL -1541 -1280
OGDH -5268 -4106
PDHA1 -2405 -4692
PDHB -133 -4587
PDHX -126 -4448
PDK1 4600 -3535
PDK2 -5450 -4464
PDK3 4747 5315
PDK4 -712 -4300
PDP1 -2175 -3641
PDP2 -2619 -3350
PDPR -632 -3822
PPARD -4213 2330
RXRA -5519 1619
SCO1 3577 -27
SCO2 -1941 -3526
SDHA -4773 -4748
SDHB 431 -4408
SDHC -3712 -4323
SLC16A1 -987 2280
SLC16A3 -4751 -4193
SLC25A14 3834 1677
SLC25A27 -2478 -5079
SUCLA2 1517 -4804
SUCLG1 -31 -4434
SUCLG2 -1167 -4765
SURF1 -1748 -3290
TACO1 651 -4903
TIMMDC1 213 -2918
TMEM126B 1024 1865
TRAP1 -5265 -2862
UCP2 -4949 4253
UCP3 -684 -4891
UQCR10 -3139 -3068
UQCRB 403 -4257
UQCRC1 -3333 -4403
UQCRC2 551 -4650
UQCRFS1 -151 -4321
UQCRH -1532 -4546
UQCRQ -1767 -3443
VDAC1 -2909 -4782



Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
metric value
setSize 96
pMANOVA 4.84e-31
p.adjustMANOVA 1.19e-28
s.dist 0.717
s.human -0.176
s.mouse -0.695
p.human 0.00289
p.mouse 4.96e-32




Top 20 genes
Gene human mouse
SDHA -4773 -4748
ACAD9 -4578 -4327
NDUFB7 -4222 -4592
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
CYC1 -4147 -4292
SDHC -3712 -4323
COX8A -4337 -3691
TRAP1 -5265 -2862
NDUFB8 -3020 -4892
UQCRC1 -3333 -4403
NDUFA3 -3805 -3788
NDUFB10 -3373 -4176
MT-CO1 -3167 -4401
COQ10A -3553 -3807
NDUFS3 -3567 -3762
NDUFAF3 -3581 -3648
COX14 -2772 -4676
MT-ND5 -3244 -3936

Click HERE to show all gene set members

All member genes
human mouse
ACAD9 -4578 -4327
COQ10A -3553 -3807
COQ10B 4344 1577
COX11 -2860 -2700
COX14 -2772 -4676
COX16 -2259 -2674
COX18 -554 -2459
COX19 3053 2889
COX20 1104 -3676
COX4I1 -2357 -3606
COX5A -2511 -4214
COX5B -2559 -4822
COX6A1 2259 -1583
COX6B1 -2231 -3407
COX6C -18 -3754
COX7B 144 -2853
COX7C -1495 -3356
COX8A -4337 -3691
CYC1 -4147 -4292
ECSIT -2655 -4003
ETFA 3160 -4491
ETFB -3614 -1903
ETFDH 1884 -4980
LRPPRC 1656 -4711
MT-CO1 -3167 -4401
MT-CYB -1355 -4115
MT-ND1 -353 -4097
MT-ND2 -1120 -4098
MT-ND4 -2086 -3521
MT-ND5 -3244 -3936
MT-ND6 816 -5003
NDUFA1 -737 -4064
NDUFA10 -1955 -4567
NDUFA11 -1033 -3018
NDUFA12 -1315 -3437
NDUFA13 -2253 -4458
NDUFA2 -1290 -3394
NDUFA3 -3805 -3788
NDUFA4 -393 -2605
NDUFA5 534 -4100
NDUFA6 -77 -4563
NDUFA7 -465 -4072
NDUFA8 -602 -3874
NDUFA9 -2868 -3934
NDUFAB1 1151 -3286
NDUFAF1 1175 -4667
NDUFAF2 3504 -3035
NDUFAF3 -3581 -3648
NDUFAF4 3740 -1490
NDUFAF5 29 -2432
NDUFAF6 -2555 -4169
NDUFAF7 2971 -1191
NDUFB10 -3373 -4176
NDUFB11 -2103 -4410
NDUFB2 -3732 -3330
NDUFB3 852 -4452
NDUFB4 -311 -2945
NDUFB5 -2039 -3251
NDUFB6 928 -2670
NDUFB7 -4222 -4592
NDUFB8 -3020 -4892
NDUFB9 -996 -4847
NDUFC1 -664 -3623
NDUFC2 34 -4249
NDUFS1 -1544 -4861
NDUFS2 -3026 -4010
NDUFS3 -3567 -3762
NDUFS4 -1690 -4308
NDUFS5 -1235 -4521
NDUFS6 -1332 -4239
NDUFS7 -4871 -3791
NDUFS8 -4325 -4250
NDUFV1 -4226 -4284
NDUFV3 -2378 -4769
NUBPL -1541 -1280
SCO1 3577 -27
SCO2 -1941 -3526
SDHA -4773 -4748
SDHB 431 -4408
SDHC -3712 -4323
SLC25A14 3834 1677
SLC25A27 -2478 -5079
SURF1 -1748 -3290
TACO1 651 -4903
TIMMDC1 213 -2918
TMEM126B 1024 1865
TRAP1 -5265 -2862
UCP2 -4949 4253
UCP3 -684 -4891
UQCR10 -3139 -3068
UQCRB 403 -4257
UQCRC1 -3333 -4403
UQCRC2 551 -4650
UQCRFS1 -151 -4321
UQCRH -1532 -4546
UQCRQ -1767 -3443



p130Cas linkage to MAPK signaling for integrins

p130Cas linkage to MAPK signaling for integrins
metric value
setSize 10
pMANOVA 0.000269
p.adjustMANOVA 0.00172
s.dist 0.705
s.human -0.141
s.mouse 0.69
p.human 0.439
p.mouse 0.000156




Top 20 genes
Gene human mouse
BCAR1 -4922 5371
SRC -3910 3763
TLN1 -3918 3071
PTK2 -2497 2145
RAP1A -689 3944
ITGB3 -488 5180
VWF -779 1730

Click HERE to show all gene set members

All member genes
human mouse
BCAR1 -4922 5371
CRK 2145 4206
FN1 35 4381
ITGB3 -488 5180
PTK2 -2497 2145
RAP1A -689 3944
RAP1B 4479 5079
SRC -3910 3763
TLN1 -3918 3071
VWF -779 1730



Postmitotic nuclear pore complex (NPC) reformation

Postmitotic nuclear pore complex (NPC) reformation
metric value
setSize 24
pMANOVA 3.9e-07
p.adjustMANOVA 6.59e-06
s.dist 0.693
s.human 0.543
s.mouse 0.43
p.human 4.11e-06
p.mouse 0.000264




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
TNPO1 3184 5474
NUP205 4438 3917
KPNB1 3619 4744
AHCTF1 4662 2760
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
RCC1 997 4917
SEH1L 1085 4110
RANGAP1 483 4468
RAN 2329 575
UBE2I 1246 733
NUP43 4562 193
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AHCTF1 4662 2760
KPNB1 3619 4744
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP93 -1503 5229
NUP98 4235 5486
RAN 2329 575
RANGAP1 483 4468
RCC1 997 4917
SEC13 730 938
SEH1L 1085 4110
SUMO1 4213 -262
TNPO1 3184 5474
UBE2I 1246 733



Cristae formation

Cristae formation
metric value
setSize 10
pMANOVA 0.000528
p.adjustMANOVA 0.00309
s.dist 0.689
s.human 0.0504
s.mouse -0.688
p.human 0.783
p.mouse 0.000166




Top 20 genes
Gene human mouse
HSPA9 2342 -3484
SAMM50 1141 -4536
MTX1 2018 -1987
CHCHD3 123 -3496
MTX2 52 -2397

Click HERE to show all gene set members

All member genes
human mouse
APOOL -69 -4059
CHCHD3 123 -3496
CHCHD6 -2177 -2974
DNAJC11 -2149 -3913
HSPA9 2342 -3484
IMMT -290 -5007
MTX1 2018 -1987
MTX2 52 -2397
SAMM50 1141 -4536
TMEM11 -1334 -2616



Mitochondrial translation

Mitochondrial translation
metric value
setSize 87
pMANOVA 1.8e-30
p.adjustMANOVA 3.54e-28
s.dist 0.687
s.human 0.158
s.mouse -0.668
p.human 0.0108
p.mouse 4.11e-27




Top 20 genes
Gene human mouse
MRPL49 4766 -4287.0
GFM1 4202 -4858.0
GFM2 3817 -5108.0
MRPL44 4401 -4096.0
PTCD3 3483 -5093.0
MRPS22 4380 -3998.0
MRPL9 3433 -4876.0
MRPL16 3084 -4785.0
MRPL18 2996 -4773.0
MRPS35 3107 -4493.0
MRPL3 2973 -4380.0
MRPS31 3506 -3633.0
MRPL19 4079 -3047.0
MRPL15 2470 -4290.0
MRPL22 3353 -2865.0
MRPL30 3497 -2718.5
ERAL1 2608 -3520.0
MRPL11 2096 -4254.0
MRPL42 2106 -4149.0
TSFM 1964 -4406.0

Click HERE to show all gene set members

All member genes
human mouse
AURKAIP1 -2308 -3467.0
CHCHD1 -543 -4442.0
DAP3 -463 354.0
ERAL1 2608 -3520.0
GADD45GIP1 -2418 -4820.0
GFM1 4202 -4858.0
GFM2 3817 -5108.0
MRPL1 -1296 -3497.0
MRPL10 -2406 -4655.0
MRPL11 2096 -4254.0
MRPL12 -2657 -3987.0
MRPL13 346 -1087.0
MRPL14 -1702 -2175.0
MRPL15 2470 -4290.0
MRPL16 3084 -4785.0
MRPL17 1930 1614.0
MRPL18 2996 -4773.0
MRPL19 4079 -3047.0
MRPL2 -437 -3027.0
MRPL20 538 -2975.0
MRPL21 1691 -1652.0
MRPL22 3353 -2865.0
MRPL23 -3221 -3820.0
MRPL24 -1884 -4451.0
MRPL27 -1616 -4786.0
MRPL28 -272 -3004.0
MRPL3 2973 -4380.0
MRPL30 3497 -2718.5
MRPL32 3068 3537.0
MRPL34 -2189 -4967.0
MRPL35 810 -3808.0
MRPL36 -560 -3281.0
MRPL37 1607 -4204.0
MRPL38 371 -3781.0
MRPL39 2592 -2566.0
MRPL4 2953 -2793.0
MRPL40 -250 -1725.0
MRPL41 -4898 -4188.0
MRPL42 2106 -4149.0
MRPL43 -1445 -3568.0
MRPL44 4401 -4096.0
MRPL46 1007 -2535.0
MRPL47 3173 -2238.0
MRPL48 -80 -1016.0
MRPL49 4766 -4287.0
MRPL50 3101 -1953.0
MRPL51 -389 -3858.0
MRPL52 -2314 -3091.0
MRPL54 -1999 -2160.0
MRPL55 1089 -4347.0
MRPL9 3433 -4876.0
MRPS10 -3085 -1917.0
MRPS11 283 -4954.0
MRPS12 -146 -4182.0
MRPS14 1795 -4725.0
MRPS15 1875 -4474.0
MRPS16 1205 -3440.0
MRPS17 -131 -2695.0
MRPS18A 469 -4626.0
MRPS18B -1874 1045.0
MRPS18C 4378 -565.0
MRPS2 1441 -2634.0
MRPS22 4380 -3998.0
MRPS23 1674 -4542.0
MRPS25 -3561 -4702.0
MRPS26 -613 -4421.0
MRPS27 563 -4117.0
MRPS28 1356 -3864.0
MRPS30 3469 -2182.0
MRPS31 3506 -3633.0
MRPS33 152 -2442.0
MRPS34 -3846 -4787.0
MRPS35 3107 -4493.0
MRPS36 -2713 -3917.0
MRPS5 -1175 -4430.0
MRPS6 -4466 1321.0
MRPS7 -1337 -1519.0
MRPS9 1405 -4915.0
MRRF -2794 77.0
MTFMT -1455 -3600.0
MTIF2 1804 -3460.0
MTIF3 279 -4638.0
MTRF1L 1519 -4781.0
OXA1L -2621 -3854.0
PTCD3 3483 -5093.0
TSFM 1964 -4406.0
TUFM -2588 -4806.0



Gluconeogenesis

Gluconeogenesis
metric value
setSize 23
pMANOVA 9.36e-07
p.adjustMANOVA 1.36e-05
s.dist 0.687
s.human -0.535
s.mouse -0.43
p.human 8.82e-06
p.mouse 0.000357




Top 20 genes
Gene human mouse
SLC25A12 -5347 -4761
GPI -5210 -4750
PGAM2 -5379 -4444
SLC37A4 -4766 -4864
ALDOA -5575 -3960
MDH2 -4361 -4332
SLC25A11 -4108 -4483
ENO3 -4671 -3886
GOT2 -3704 -4606
FBP2 -3323 -4689
TPI1 -3377 -4322
GOT1 -3758 -3482
SLC37A1 -2590 -1968
PGK1 -1414 -3278
MDH1 -1091 -4150
G6PC3 -3066 -1440

Click HERE to show all gene set members

All member genes
human mouse
ALDOA -5575 -3960
ALDOC 1379 4069
ENO1 -4083 2108
ENO2 -2024 606
ENO3 -4671 -3886
FBP2 -3323 -4689
G6PC3 -3066 -1440
GOT1 -3758 -3482
GOT2 -3704 -4606
GPI -5210 -4750
MDH1 -1091 -4150
MDH2 -4361 -4332
PC -5226 851
PCK2 -2317 969
PGAM2 -5379 -4444
PGK1 -1414 -3278
SLC25A1 -2688 4605
SLC25A11 -4108 -4483
SLC25A12 -5347 -4761
SLC25A13 4283 2507
SLC37A1 -2590 -1968
SLC37A4 -4766 -4864
TPI1 -3377 -4322



Mitochondrial translation elongation

Mitochondrial translation elongation
metric value
setSize 81
pMANOVA 4.11e-28
p.adjustMANOVA 6.33e-26
s.dist 0.683
s.human 0.158
s.mouse -0.664
p.human 0.0139
p.mouse 4.54e-25




Top 20 genes
Gene human mouse
MRPL49 4766 -4287.0
GFM1 4202 -4858.0
MRPL44 4401 -4096.0
PTCD3 3483 -5093.0
MRPS22 4380 -3998.0
MRPL9 3433 -4876.0
MRPL16 3084 -4785.0
MRPL18 2996 -4773.0
MRPS35 3107 -4493.0
MRPL3 2973 -4380.0
MRPS31 3506 -3633.0
MRPL19 4079 -3047.0
MRPL15 2470 -4290.0
MRPL22 3353 -2865.0
MRPL30 3497 -2718.5
ERAL1 2608 -3520.0
MRPL11 2096 -4254.0
MRPL42 2106 -4149.0
TSFM 1964 -4406.0
MRPS14 1795 -4725.0

Click HERE to show all gene set members

All member genes
human mouse
AURKAIP1 -2308 -3467.0
CHCHD1 -543 -4442.0
DAP3 -463 354.0
ERAL1 2608 -3520.0
GADD45GIP1 -2418 -4820.0
GFM1 4202 -4858.0
MRPL1 -1296 -3497.0
MRPL10 -2406 -4655.0
MRPL11 2096 -4254.0
MRPL12 -2657 -3987.0
MRPL13 346 -1087.0
MRPL14 -1702 -2175.0
MRPL15 2470 -4290.0
MRPL16 3084 -4785.0
MRPL17 1930 1614.0
MRPL18 2996 -4773.0
MRPL19 4079 -3047.0
MRPL2 -437 -3027.0
MRPL20 538 -2975.0
MRPL21 1691 -1652.0
MRPL22 3353 -2865.0
MRPL23 -3221 -3820.0
MRPL24 -1884 -4451.0
MRPL27 -1616 -4786.0
MRPL28 -272 -3004.0
MRPL3 2973 -4380.0
MRPL30 3497 -2718.5
MRPL32 3068 3537.0
MRPL34 -2189 -4967.0
MRPL35 810 -3808.0
MRPL36 -560 -3281.0
MRPL37 1607 -4204.0
MRPL38 371 -3781.0
MRPL39 2592 -2566.0
MRPL4 2953 -2793.0
MRPL40 -250 -1725.0
MRPL41 -4898 -4188.0
MRPL42 2106 -4149.0
MRPL43 -1445 -3568.0
MRPL44 4401 -4096.0
MRPL46 1007 -2535.0
MRPL47 3173 -2238.0
MRPL48 -80 -1016.0
MRPL49 4766 -4287.0
MRPL50 3101 -1953.0
MRPL51 -389 -3858.0
MRPL52 -2314 -3091.0
MRPL54 -1999 -2160.0
MRPL55 1089 -4347.0
MRPL9 3433 -4876.0
MRPS10 -3085 -1917.0
MRPS11 283 -4954.0
MRPS12 -146 -4182.0
MRPS14 1795 -4725.0
MRPS15 1875 -4474.0
MRPS16 1205 -3440.0
MRPS17 -131 -2695.0
MRPS18A 469 -4626.0
MRPS18B -1874 1045.0
MRPS18C 4378 -565.0
MRPS2 1441 -2634.0
MRPS22 4380 -3998.0
MRPS23 1674 -4542.0
MRPS25 -3561 -4702.0
MRPS26 -613 -4421.0
MRPS27 563 -4117.0
MRPS28 1356 -3864.0
MRPS30 3469 -2182.0
MRPS31 3506 -3633.0
MRPS33 152 -2442.0
MRPS34 -3846 -4787.0
MRPS35 3107 -4493.0
MRPS36 -2713 -3917.0
MRPS5 -1175 -4430.0
MRPS6 -4466 1321.0
MRPS7 -1337 -1519.0
MRPS9 1405 -4915.0
OXA1L -2621 -3854.0
PTCD3 3483 -5093.0
TSFM 1964 -4406.0
TUFM -2588 -4806.0



Mitochondrial translation initiation

Mitochondrial translation initiation
metric value
setSize 81
pMANOVA 1.72e-27
p.adjustMANOVA 1.77e-25
s.dist 0.676
s.human 0.152
s.mouse -0.659
p.human 0.0186
p.mouse 1.12e-24




Top 20 genes
Gene human mouse
MRPL49 4766 -4287.0
MRPL44 4401 -4096.0
PTCD3 3483 -5093.0
MRPS22 4380 -3998.0
MRPL9 3433 -4876.0
MRPL16 3084 -4785.0
MRPL18 2996 -4773.0
MRPS35 3107 -4493.0
MRPL3 2973 -4380.0
MRPS31 3506 -3633.0
MRPL19 4079 -3047.0
MRPL15 2470 -4290.0
MRPL22 3353 -2865.0
MRPL30 3497 -2718.5
ERAL1 2608 -3520.0
MRPL11 2096 -4254.0
MRPL42 2106 -4149.0
MRPS14 1795 -4725.0
MRPS15 1875 -4474.0
MRPL4 2953 -2793.0

Click HERE to show all gene set members

All member genes
human mouse
AURKAIP1 -2308 -3467.0
CHCHD1 -543 -4442.0
DAP3 -463 354.0
ERAL1 2608 -3520.0
GADD45GIP1 -2418 -4820.0
MRPL1 -1296 -3497.0
MRPL10 -2406 -4655.0
MRPL11 2096 -4254.0
MRPL12 -2657 -3987.0
MRPL13 346 -1087.0
MRPL14 -1702 -2175.0
MRPL15 2470 -4290.0
MRPL16 3084 -4785.0
MRPL17 1930 1614.0
MRPL18 2996 -4773.0
MRPL19 4079 -3047.0
MRPL2 -437 -3027.0
MRPL20 538 -2975.0
MRPL21 1691 -1652.0
MRPL22 3353 -2865.0
MRPL23 -3221 -3820.0
MRPL24 -1884 -4451.0
MRPL27 -1616 -4786.0
MRPL28 -272 -3004.0
MRPL3 2973 -4380.0
MRPL30 3497 -2718.5
MRPL32 3068 3537.0
MRPL34 -2189 -4967.0
MRPL35 810 -3808.0
MRPL36 -560 -3281.0
MRPL37 1607 -4204.0
MRPL38 371 -3781.0
MRPL39 2592 -2566.0
MRPL4 2953 -2793.0
MRPL40 -250 -1725.0
MRPL41 -4898 -4188.0
MRPL42 2106 -4149.0
MRPL43 -1445 -3568.0
MRPL44 4401 -4096.0
MRPL46 1007 -2535.0
MRPL47 3173 -2238.0
MRPL48 -80 -1016.0
MRPL49 4766 -4287.0
MRPL50 3101 -1953.0
MRPL51 -389 -3858.0
MRPL52 -2314 -3091.0
MRPL54 -1999 -2160.0
MRPL55 1089 -4347.0
MRPL9 3433 -4876.0
MRPS10 -3085 -1917.0
MRPS11 283 -4954.0
MRPS12 -146 -4182.0
MRPS14 1795 -4725.0
MRPS15 1875 -4474.0
MRPS16 1205 -3440.0
MRPS17 -131 -2695.0
MRPS18A 469 -4626.0
MRPS18B -1874 1045.0
MRPS18C 4378 -565.0
MRPS2 1441 -2634.0
MRPS22 4380 -3998.0
MRPS23 1674 -4542.0
MRPS25 -3561 -4702.0
MRPS26 -613 -4421.0
MRPS27 563 -4117.0
MRPS28 1356 -3864.0
MRPS30 3469 -2182.0
MRPS31 3506 -3633.0
MRPS33 152 -2442.0
MRPS34 -3846 -4787.0
MRPS35 3107 -4493.0
MRPS36 -2713 -3917.0
MRPS5 -1175 -4430.0
MRPS6 -4466 1321.0
MRPS7 -1337 -1519.0
MRPS9 1405 -4915.0
MTFMT -1455 -3600.0
MTIF2 1804 -3460.0
MTIF3 279 -4638.0
OXA1L -2621 -3854.0
PTCD3 3483 -5093.0



Mitochondrial translation termination

Mitochondrial translation termination
metric value
setSize 81
pMANOVA 2.71e-27
p.adjustMANOVA 2.57e-25
s.dist 0.673
s.human 0.156
s.mouse -0.654
p.human 0.0154
p.mouse 2.28e-24




Top 20 genes
Gene human mouse
MRPL49 4766 -4287.0
GFM2 3817 -5108.0
MRPL44 4401 -4096.0
PTCD3 3483 -5093.0
MRPS22 4380 -3998.0
MRPL9 3433 -4876.0
MRPL16 3084 -4785.0
MRPL18 2996 -4773.0
MRPS35 3107 -4493.0
MRPL3 2973 -4380.0
MRPS31 3506 -3633.0
MRPL19 4079 -3047.0
MRPL15 2470 -4290.0
MRPL22 3353 -2865.0
MRPL30 3497 -2718.5
ERAL1 2608 -3520.0
MRPL11 2096 -4254.0
MRPL42 2106 -4149.0
MRPS14 1795 -4725.0
MRPS15 1875 -4474.0

Click HERE to show all gene set members

All member genes
human mouse
AURKAIP1 -2308 -3467.0
CHCHD1 -543 -4442.0
DAP3 -463 354.0
ERAL1 2608 -3520.0
GADD45GIP1 -2418 -4820.0
GFM2 3817 -5108.0
MRPL1 -1296 -3497.0
MRPL10 -2406 -4655.0
MRPL11 2096 -4254.0
MRPL12 -2657 -3987.0
MRPL13 346 -1087.0
MRPL14 -1702 -2175.0
MRPL15 2470 -4290.0
MRPL16 3084 -4785.0
MRPL17 1930 1614.0
MRPL18 2996 -4773.0
MRPL19 4079 -3047.0
MRPL2 -437 -3027.0
MRPL20 538 -2975.0
MRPL21 1691 -1652.0
MRPL22 3353 -2865.0
MRPL23 -3221 -3820.0
MRPL24 -1884 -4451.0
MRPL27 -1616 -4786.0
MRPL28 -272 -3004.0
MRPL3 2973 -4380.0
MRPL30 3497 -2718.5
MRPL32 3068 3537.0
MRPL34 -2189 -4967.0
MRPL35 810 -3808.0
MRPL36 -560 -3281.0
MRPL37 1607 -4204.0
MRPL38 371 -3781.0
MRPL39 2592 -2566.0
MRPL4 2953 -2793.0
MRPL40 -250 -1725.0
MRPL41 -4898 -4188.0
MRPL42 2106 -4149.0
MRPL43 -1445 -3568.0
MRPL44 4401 -4096.0
MRPL46 1007 -2535.0
MRPL47 3173 -2238.0
MRPL48 -80 -1016.0
MRPL49 4766 -4287.0
MRPL50 3101 -1953.0
MRPL51 -389 -3858.0
MRPL52 -2314 -3091.0
MRPL54 -1999 -2160.0
MRPL55 1089 -4347.0
MRPL9 3433 -4876.0
MRPS10 -3085 -1917.0
MRPS11 283 -4954.0
MRPS12 -146 -4182.0
MRPS14 1795 -4725.0
MRPS15 1875 -4474.0
MRPS16 1205 -3440.0
MRPS17 -131 -2695.0
MRPS18A 469 -4626.0
MRPS18B -1874 1045.0
MRPS18C 4378 -565.0
MRPS2 1441 -2634.0
MRPS22 4380 -3998.0
MRPS23 1674 -4542.0
MRPS25 -3561 -4702.0
MRPS26 -613 -4421.0
MRPS27 563 -4117.0
MRPS28 1356 -3864.0
MRPS30 3469 -2182.0
MRPS31 3506 -3633.0
MRPS33 152 -2442.0
MRPS34 -3846 -4787.0
MRPS35 3107 -4493.0
MRPS36 -2713 -3917.0
MRPS5 -1175 -4430.0
MRPS6 -4466 1321.0
MRPS7 -1337 -1519.0
MRPS9 1405 -4915.0
MRRF -2794 77.0
MTRF1L 1519 -4781.0
OXA1L -2621 -3854.0
PTCD3 3483 -5093.0



Heme biosynthesis

Heme biosynthesis
metric value
setSize 12
pMANOVA 0.000457
p.adjustMANOVA 0.00271
s.dist 0.666
s.human -0.128
s.mouse -0.654
p.human 0.444
p.mouse 8.8e-05




Top 20 genes
Gene human mouse
ALAD -3855 -4632
FECH -3768 -4627
HMBS -3958 -3897
PPOX -3785 -3297
UROS -1848 -3787
CPOX -865 -3501

Click HERE to show all gene set members

All member genes
human mouse
ABCG2 -2465 5301
ALAD -3855 -4632
ALAS1 3230 -4733
COX10 2735 -4631
COX15 571 -5005
CPOX -865 -3501
FECH -3768 -4627
FLVCR1 1431 -2760
HMBS -3958 -3897
PPOX -3785 -3297
UROD 795 -3628
UROS -1848 -3787



Transport of Ribonucleoproteins into the Host Nucleus

Transport of Ribonucleoproteins into the Host Nucleus
metric value
setSize 25
pMANOVA 7.08e-07
p.adjustMANOVA 1.08e-05
s.dist 0.663
s.human 0.541
s.mouse 0.383
p.human 2.84e-06
p.mouse 0.000914




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
KPNB1 3619 4744
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
KPNA1 1833 4786
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
KPNA1 1833 4786
KPNB1 3619 4744
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation
metric value
setSize 20
pMANOVA 4.64e-06
p.adjustMANOVA 4.57e-05
s.dist 0.66
s.human -0.172
s.mouse -0.637
p.human 0.183
p.mouse 8.05e-07




Top 20 genes
Gene human mouse
GRHPR -4730 -4938
OGDH -5268 -4106
DDO -3779 -4874
GOT2 -3704 -4606
BCKDHB -4241 -2970
PDHA1 -2405 -4692
ALDH4A1 -2303 -3918
PXMP2 -1741 -4990
DLAT -1960 -4426
LIAS -1131 -4063
DLST -323 -4762
DHTKD1 -419 -3519
PDHB -133 -4587
PDHX -126 -4448
GCSH -140 -2869

Click HERE to show all gene set members

All member genes
human mouse
ALDH4A1 -2303 -3918
BCKDHB -4241 -2970
DBT 2001 5426
DDO -3779 -4874
DHTKD1 -419 -3519
DLAT -1960 -4426
DLD 1187 -4834
DLST -323 -4762
GCSH -140 -2869
GOT2 -3704 -4606
GRHPR -4730 -4938
LIAS -1131 -4063
LIPT1 3416 5104
LIPT2 299 -2164
NDUFAB1 1151 -3286
OGDH -5268 -4106
PDHA1 -2405 -4692
PDHB -133 -4587
PDHX -126 -4448
PXMP2 -1741 -4990



Post-chaperonin tubulin folding pathway

Post-chaperonin tubulin folding pathway
metric value
setSize 15
pMANOVA 7.81e-06
p.adjustMANOVA 7.24e-05
s.dist 0.656
s.human -0.483
s.mouse 0.444
p.human 0.00121
p.mouse 0.00289




Top 20 genes
Gene human mouse
TUBA1B -5324 5343
TUBB6 -5060 5524
TUBA1C -4883 5415
TUBB2B -4704 5335
TUBB2A -4676 5002
TUBA1A -5228 4221
TBCD -4133 1170
TUBA4A -5342 240
TBCE -454 2191
TBCA -2582 292

Click HERE to show all gene set members

All member genes
human mouse
ARL2 -4142 -2108
TBCA -2582 292
TBCB 1115 -91
TBCC 3030 2416
TBCD -4133 1170
TBCE -454 2191
TUBA1A -5228 4221
TUBA1B -5324 5343
TUBA1C -4883 5415
TUBA4A -5342 240
TUBA8 -1116 -946
TUBB2A -4676 5002
TUBB2B -4704 5335
TUBB4B 430 4642
TUBB6 -5060 5524



Transport of the SLBP Dependant Mature mRNA

Transport of the SLBP Dependant Mature mRNA
metric value
setSize 29
pMANOVA 1.05e-07
p.adjustMANOVA 1.96e-06
s.dist 0.652
s.human 0.556
s.mouse 0.341
p.human 2.2e-07
p.mouse 0.00148




Top 20 genes
Gene human mouse
NUP98 4235 5486
ALYREF 5008 4414
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
SLBP 2666 4469
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
EIF4E 2892 2481
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
ALYREF 5008 4414
EIF4E 2892 2481
NCBP1 -1736 4720
NCBP2 4188 -2519
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
NXF1 4992 -1556
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
SLBP 2666 4469
TPR 2984 275



Nuclear import of Rev protein

Nuclear import of Rev protein
metric value
setSize 26
pMANOVA 6.95e-07
p.adjustMANOVA 1.07e-05
s.dist 0.65
s.human 0.533
s.mouse 0.372
p.human 2.52e-06
p.mouse 0.00103




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
KPNB1 3619 4744
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
RCC1 997 4917
SEH1L 1085 4110
NUP88 1244 1407
RAN 2329 575
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
KPNB1 3619 4744
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RAN 2329 575
RANBP2 4470 -562
RCC1 997 4917
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



Export of Viral Ribonucleoproteins from Nucleus

Export of Viral Ribonucleoproteins from Nucleus
metric value
setSize 26
pMANOVA 6.72e-07
p.adjustMANOVA 1.05e-05
s.dist 0.65
s.human 0.542
s.mouse 0.358
p.human 1.69e-06
p.mouse 0.0016




Top 20 genes
Gene human mouse
HSPA1A 4887 5534.5
NUP98 4235 5486.0
NUP54 4508 4751.0
NUP153 4762 4031.0
NUP205 4438 3917.0
RAE1 4471 3078.0
NUP155 4306 2897.0
NUP35 4571 2515.0
NUP107 3232 3195.0
NUP188 2117 4593.0
NUP160 3998 2314.0
NUP214 3124 1845.0
SEH1L 1085 4110.0
XPO1 990 2133.0
NUP88 1244 1407.0
RAN 2329 575.0
NUP43 4562 193.0
TPR 2984 275.0
NUP85 3181 227.0
SEC13 730 938.0

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40.0
HSPA1A 4887 5534.5
NDC1 1273 -322.0
NUP107 3232 3195.0
NUP133 889 -2580.0
NUP153 4762 4031.0
NUP155 4306 2897.0
NUP160 3998 2314.0
NUP188 2117 4593.0
NUP205 4438 3917.0
NUP214 3124 1845.0
NUP35 4571 2515.0
NUP37 -327 -873.0
NUP43 4562 193.0
NUP54 4508 4751.0
NUP85 3181 227.0
NUP88 1244 1407.0
NUP93 -1503 5229.0
NUP98 4235 5486.0
RAE1 4471 3078.0
RAN 2329 575.0
RANBP2 4470 -562.0
SEC13 730 938.0
SEH1L 1085 4110.0
TPR 2984 275.0
XPO1 990 2133.0



rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
metric value
setSize 52
pMANOVA 1.37e-13
p.adjustMANOVA 7.04e-12
s.dist 0.649
s.human 0.6
s.mouse 0.247
p.human 7.07e-14
p.mouse 0.00209




Top 20 genes
Gene human mouse
HEATR1 4911 5214.0
UTP14A 4777 5328.5
WDR43 4883 4985.0
DCAF13 4800 4904.0
WDR3 4838 4572.0
NOP58 4891 3903.0
NOL6 3819 4849.0
NOP2 3472 5052.0
GAR1 4132 4232.0
WDR75 3743 3744.0
UTP3 4917 2335.0
IMP4 2805 4037.0
NOP56 3099 3605.0
MPHOSPH10 3928 2821.0
WDR36 4542 2424.0
WDR46 3335 3009.0
NAT10 3642 2679.0
NOL11 4916 1935.0
DDX49 2178 4308.0
RRP7A 2138 4236.0

Click HERE to show all gene set members

All member genes
human mouse
BMS1 3511 -3149.0
DCAF13 4800 4904.0
DDX47 3735 -2506.0
DDX49 2178 4308.0
DHX37 2105 3594.0
DIEXF 4877 -510.0
DIMT1 2537 42.0
DKC1 3629 1648.0
FBL 4233 -132.0
FCF1 3303 1429.0
GAR1 4132 4232.0
HEATR1 4911 5214.0
IMP3 4536 -4210.0
IMP4 2805 4037.0
KRR1 3921 -1381.0
MPHOSPH10 3928 2821.0
NAT10 3642 2679.0
NHP2 694 1773.0
NOC4L 1763 -2682.0
NOL11 4916 1935.0
NOL6 3819 4849.0
NOP10 1336 -894.0
NOP14 1590 4297.0
NOP2 3472 5052.0
NOP56 3099 3605.0
NOP58 4891 3903.0
PDCD11 -1465 862.0
PNO1 4623 -406.0
PWP2 2462 1711.0
RCL1 3257 237.0
RPS14 -1412 122.0
RPS6 -245 1237.0
RPS9 -1107 -2477.0
RRP36 1532 29.0
RRP7A 2138 4236.0
RRP9 771 1609.0
TBL3 -1551 3495.0
THUMPD1 4666 -558.0
TSR3 -3611 -4069.0
UTP14A 4777 5328.5
UTP14C 1565 5328.5
UTP15 4137 -396.0
UTP18 3851 2069.0
UTP20 4174 832.0
UTP3 4917 2335.0
UTP6 4779 -1773.0
WBSCR22 1741 -4222.0
WDR3 4838 4572.0
WDR36 4542 2424.0
WDR43 4883 4985.0
WDR46 3335 3009.0
WDR75 3743 3744.0



Transport of the SLBP independent Mature mRNA

Transport of the SLBP independent Mature mRNA
metric value
setSize 28
pMANOVA 2.57e-07
p.adjustMANOVA 4.47e-06
s.dist 0.644
s.human 0.556
s.mouse 0.325
p.human 3.58e-07
p.mouse 0.00296




Top 20 genes
Gene human mouse
NUP98 4235 5486
ALYREF 5008 4414
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
EIF4E 2892 2481
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
ALYREF 5008 4414
EIF4E 2892 2481
NCBP1 -1736 4720
NCBP2 4188 -2519
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
NXF1 4992 -1556
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



GRB2:SOS provides linkage to MAPK signaling for Integrins

GRB2:SOS provides linkage to MAPK signaling for Integrins
metric value
setSize 10
pMANOVA 0.000836
p.adjustMANOVA 0.00454
s.dist 0.644
s.human -0.202
s.mouse 0.611
p.human 0.269
p.mouse 0.00082




Top 20 genes
Gene human mouse
SRC -3910 3763
GRB2 -4050 3027
TLN1 -3918 3071
PTK2 -2497 2145
SOS1 -1962 2326
RAP1A -689 3944
ITGB3 -488 5180
VWF -779 1730

Click HERE to show all gene set members

All member genes
human mouse
FN1 35 4381
GRB2 -4050 3027
ITGB3 -488 5180
PTK2 -2497 2145
RAP1A -689 3944
RAP1B 4479 5079
SOS1 -1962 2326
SRC -3910 3763
TLN1 -3918 3071
VWF -779 1730



Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
metric value
setSize 23
pMANOVA 5.26e-06
p.adjustMANOVA 4.98e-05
s.dist 0.638
s.human 0.538
s.mouse 0.342
p.human 7.84e-06
p.mouse 0.00454




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



Regulation of Glucokinase by Glucokinase Regulatory Protein

Regulation of Glucokinase by Glucokinase Regulatory Protein
metric value
setSize 23
pMANOVA 5.26e-06
p.adjustMANOVA 4.98e-05
s.dist 0.638
s.human 0.538
s.mouse 0.342
p.human 7.84e-06
p.mouse 0.00454




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



Interactions of Rev with host cellular proteins

Interactions of Rev with host cellular proteins
metric value
setSize 29
pMANOVA 2.81e-07
p.adjustMANOVA 4.81e-06
s.dist 0.638
s.human 0.499
s.mouse 0.398
p.human 3.39e-06
p.mouse 0.000213




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
KPNB1 3619 4744
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
RCC1 997 4917
SEH1L 1085 4110
RANBP1 745 3863
RANGAP1 483 4468
XPO1 990 2133
NUP88 1244 1407
RAN 2329 575
NUP43 4562 193

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
KPNB1 3619 4744
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RAN 2329 575
RANBP1 745 3863
RANBP2 4470 -562
RANGAP1 483 4468
RCC1 997 4917
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275
XPO1 990 2133



Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
metric value
setSize 17
pMANOVA 1.31e-05
p.adjustMANOVA 0.00011
s.dist 0.637
s.human -0.0952
s.mouse 0.63
p.human 0.497
p.mouse 6.85e-06




Top 20 genes
Gene human mouse
TUBA1B -5324 5343
TUBB6 -5060 5524
TUBA1C -4883 5415
TUBB2B -4704 5335
TUBB2A -4676 5002
TUBA1A -5228 4221
TUBA4A -5342 240

Click HERE to show all gene set members

All member genes
human mouse
CCT2 3805 5006
CCT3 2328 5268
CCT4 950 3312
CCT5 3075 2497
CCT6A 2932 4488
CCT7 436 913
CCT8 4149 3936
TCP1 4480 394
TUBA1A -5228 4221
TUBA1B -5324 5343
TUBA1C -4883 5415
TUBA4A -5342 240
TUBA8 -1116 -946
TUBB2A -4676 5002
TUBB2B -4704 5335
TUBB4B 430 4642
TUBB6 -5060 5524



Pyruvate metabolism

Pyruvate metabolism
metric value
setSize 26
pMANOVA 8.21e-07
p.adjustMANOVA 1.2e-05
s.dist 0.629
s.human -0.228
s.mouse -0.586
p.human 0.0443
p.mouse 2.27e-07




Top 20 genes
Gene human mouse
PDK2 -5450 -4464
SLC16A3 -4751 -4193
MPC1 -3681 -4360
VDAC1 -2909 -4782
HAGH -4509 -2740
PDHA1 -2405 -4692
GSTZ1 -2068 -5077
LDHA -3251 -3213
PDP2 -2619 -3350
DLAT -1960 -4426
BSG -2248 -3662
PDP1 -2175 -3641
LDHB -1491 -4379
PDK4 -712 -4300
GLO1 -678 -4289
PDPR -632 -3822
PDHB -133 -4587
PDHX -126 -4448

Click HERE to show all gene set members

All member genes
human mouse
BSG -2248 -3662
DLAT -1960 -4426
DLD 1187 -4834
GLO1 -678 -4289
GSTZ1 -2068 -5077
HAGH -4509 -2740
LDHA -3251 -3213
LDHB -1491 -4379
ME1 1789 -534
MPC1 -3681 -4360
MPC2 829 -3712
PDHA1 -2405 -4692
PDHB -133 -4587
PDHX -126 -4448
PDK1 4600 -3535
PDK2 -5450 -4464
PDK3 4747 5315
PDK4 -712 -4300
PDP1 -2175 -3641
PDP2 -2619 -3350
PDPR -632 -3822
PPARD -4213 2330
RXRA -5519 1619
SLC16A1 -987 2280
SLC16A3 -4751 -4193
VDAC1 -2909 -4782



SUMOylation of ubiquitinylation proteins

SUMOylation of ubiquitinylation proteins
metric value
setSize 31
pMANOVA 1.24e-07
p.adjustMANOVA 2.25e-06
s.dist 0.629
s.human 0.53
s.mouse 0.339
p.human 3.33e-07
p.mouse 0.00111




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
MDM2 3253 5156
RAE1 4471 3078
NUP155 4306 2897
TRIM27 4120 2963
NUP35 4571 2515
PML 3338 3242
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
PIAS2 2406 3815
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
UBE2I 1246 733
NUP43 4562 193
TPR 2984 275

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
MDM2 3253 5156
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
PIAS1 57 627
PIAS2 2406 3815
PIAS4 342 -629
PML 3338 3242
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
SUMO1 4213 -262
TPR 2984 275
TRIM27 4120 2963
UBE2I 1246 733



Striated Muscle Contraction

Striated Muscle Contraction
metric value
setSize 30
pMANOVA 6.56e-08
p.adjustMANOVA 1.33e-06
s.dist 0.627
s.human -0.603
s.mouse -0.174
p.human 1.1e-08
p.mouse 0.0988




Top 20 genes
Gene human mouse
TNNI2 -4910 -4080
MYL3 -3976 -4930
TPM1 -4592 -3836
TNNT3 -4247 -4046
TCAP -5032 -3354
MYBPC2 -5048 -3336
MYL2 -4849 -3472
TNNC2 -4220 -3878
TPM2 -3443 -4155
TMOD1 -5339 -2629
MYBPC1 -4465 -2024
TNNT1 -4248 -1804
NEB -2805 -2418
TNNC1 -4638 -1320
ACTN2 -3104 -1086
DMD -2970 -997
MYL1 -1989 -784

Click HERE to show all gene set members

All member genes
human mouse
ACTN2 -3104 -1086
DES -4740 4011
DMD -2970 -997
MYBPC1 -4465 -2024
MYBPC2 -5048 -3336
MYH3 -4216 2204
MYH6 -4746 1464
MYH8 -4002 4637
MYL1 -1989 -784
MYL2 -4849 -3472
MYL3 -3976 -4930
MYL4 -4626 2885
NEB -2805 -2418
TCAP -5032 -3354
TMOD1 -5339 -2629
TMOD2 -2848 1289
TMOD3 376 681
TNNC1 -4638 -1320
TNNC2 -4220 -3878
TNNI1 -3744 162
TNNI2 -4910 -4080
TNNT1 -4248 -1804
TNNT2 -3984 1022
TNNT3 -4247 -4046
TPM1 -4592 -3836
TPM2 -3443 -4155
TPM3 -3868 727
TPM4 191 4980
TTN 3968 -2380
VIM -3027 5076



Mitochondrial tRNA aminoacylation

Mitochondrial tRNA aminoacylation
metric value
setSize 18
pMANOVA 6.03e-06
p.adjustMANOVA 5.63e-05
s.dist 0.627
s.human 0.178
s.mouse -0.601
p.human 0.19
p.mouse 9.99e-06




Top 20 genes
Gene human mouse
MARS2 4685 -3490
YARS2 4860 -3192
HARS2 4723 -3250
FARS2 2754 -3851
IARS2 1951 -5054
NARS2 2046 -3967
DARS2 1640 -4113
LARS2 2120 -2275

Click HERE to show all gene set members

All member genes
human mouse
AARS2 -2670 -4760
CARS2 -2768 -2892
DARS2 1640 -4113
EARS2 -2493 -453
FARS2 2754 -3851
HARS2 4723 -3250
IARS2 1951 -5054
LARS2 2120 -2275
MARS2 4685 -3490
NARS2 2046 -3967
PARS2 2650 514
PPA2 -163 -3735
RARS2 -56 -1764
SARS2 -3583 -4897
TARS2 -526 -3362
VARS2 -2639 -4749
WARS2 -890 1542
YARS2 4860 -3192



SUMOylation of SUMOylation proteins

SUMOylation of SUMOylation proteins
metric value
setSize 27
pMANOVA 1.07e-06
p.adjustMANOVA 1.47e-05
s.dist 0.623
s.human 0.542
s.mouse 0.307
p.human 1.08e-06
p.mouse 0.00586




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
TOPORS 4963 3173
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
SEH1L 1085 4110
NUP88 1244 1407
UBE2I 1246 733
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
PIAS4 342 -629
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
SUMO1 4213 -262
TOPORS 4963 3173
TPR 2984 275
UBE2I 1246 733



NEP/NS2 Interacts with the Cellular Export Machinery

NEP/NS2 Interacts with the Cellular Export Machinery
metric value
setSize 25
pMANOVA 3.62e-06
p.adjustMANOVA 3.78e-05
s.dist 0.621
s.human 0.525
s.mouse 0.332
p.human 5.54e-06
p.mouse 0.00409




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
SEH1L 1085 4110
XPO1 990 2133
NUP88 1244 1407
RAN 2329 575
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RAN 2329 575
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275
XPO1 990 2133



Rev-mediated nuclear export of HIV RNA

Rev-mediated nuclear export of HIV RNA
metric value
setSize 28
pMANOVA 9.94e-07
p.adjustMANOVA 1.41e-05
s.dist 0.621
s.human 0.49
s.mouse 0.381
p.human 7.25e-06
p.mouse 0.000483




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
NUP214 3124 1845
RCC1 997 4917
SEH1L 1085 4110
RANBP1 745 3863
RANGAP1 483 4468
XPO1 990 2133
NUP88 1244 1407
RAN 2329 575
NUP43 4562 193
TPR 2984 275

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RAN 2329 575
RANBP1 745 3863
RANBP2 4470 -562
RANGAP1 483 4468
RCC1 997 4917
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275
XPO1 990 2133



Signal regulatory protein family interactions

Signal regulatory protein family interactions
metric value
setSize 10
pMANOVA 0.001
p.adjustMANOVA 0.00532
s.dist 0.616
s.human -0.412
s.mouse 0.458
p.human 0.0241
p.mouse 0.0122




Top 20 genes
Gene human mouse
SIRPA -5627 4799
SRC -3910 3763
GRB2 -4050 3027
PTK2B -2461 2430
PTK2 -2497 2145
PTPN11 -1575 3105
PTPN6 -931 4180
CD47 -2184 997

Click HERE to show all gene set members

All member genes
human mouse
CD47 -2184 997
FYB -2235 -89
GRB2 -4050 3027
PTK2 -2497 2145
PTK2B -2461 2430
PTPN11 -1575 3105
PTPN6 -931 4180
SIRPA -5627 4799
SKAP2 518 2144
SRC -3910 3763



Vpr-mediated nuclear import of PICs

Vpr-mediated nuclear import of PICs
metric value
setSize 27
pMANOVA 2.78e-06
p.adjustMANOVA 2.96e-05
s.dist 0.607
s.human 0.492
s.mouse 0.355
p.human 9.7e-06
p.mouse 0.0014




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
KPNA1 1833 4786
NUP214 3124 1845
PSIP1 3390 1448
SEH1L 1085 4110
HMGA1 598 5468
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275
NUP85 3181 227
SEC13 730 938

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
BANF1 -2281 -1690
HMGA1 598 5468
KPNA1 1833 4786
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
PSIP1 3390 1448
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation
metric value
setSize 18
pMANOVA 0.000105
p.adjustMANOVA 0.000749
s.dist 0.603
s.human -0.579
s.mouse -0.167
p.human 2.11e-05
p.mouse 0.219




Top 20 genes
Gene human mouse
CACNB1 -5285 -4156
CAMK2A -5527 -3819
SCN4A -5601 -3596
CACNG6 -5276 -3813
CAMK2B -5497 -2856
SCN1B -4899 -3023
SCN2B -4268 -3399
RANGRF -4019 -2978
CAMK2G -2097 -4184
FGF11 -3896 -1457

Click HERE to show all gene set members

All member genes
human mouse
CACNA1C -762 1596
CACNB1 -5285 -4156
CACNG6 -5276 -3813
CALM1 -4464 1071
CAMK2A -5527 -3819
CAMK2B -5497 -2856
CAMK2D -2223 5094
CAMK2G -2097 -4184
FGF11 -3896 -1457
FGF13 -844 801
RANGRF -4019 -2978
SCN1B -4899 -3023
SCN2A 544 1112
SCN2B -4268 -3399
SCN3A 2439 4272
SCN3B -3892 3499
SCN4A -5601 -3596
SCN5A -5309 3639



Mitochondrial protein import

Mitochondrial protein import
metric value
setSize 55
pMANOVA 5.13e-14
p.adjustMANOVA 2.87e-12
s.dist 0.602
s.human -0.00782
s.mouse -0.602
p.human 0.92
p.mouse 1.19e-14




Top 20 genes
Gene human mouse
SLC25A12 -5347 -4761
CHCHD10 -4902 -3931
TAZ -3604 -4956
CYC1 -4147 -4292
ACO2 -3822 -4534
IDH3G -4178 -3714
NDUFB8 -3020 -4892
VDAC1 -2909 -4782
LDHD -5163 -2192
TIMM17B -3141 -2749
TIMM13 -3591 -2117
PAM16 -2464 -2969
FXN -2179 -3293
TOMM7 -1885 -3378
SLC25A4 -1327 -4427
TIMM44 -1151 -5068
COQ2 -1700 -3133
CHCHD4 -2167 -2361
GRPEL1 -2346 -2045
BCS1L -1023 -4605

Click HERE to show all gene set members

All member genes
human mouse
ACO2 -3822 -4534
BCS1L -1023 -4605
CHCHD10 -4902 -3931
CHCHD2 446 -3053
CHCHD3 123 -3496
CHCHD4 -2167 -2361
CHCHD5 -2111 -2033
CHCHD7 2643 -1066
CMC2 3597 -4660
COA4 -3800 -973
COA6 4111 -3650
COQ2 -1700 -3133
COX17 -2094 -1938
COX19 3053 2889
CS 3653 -4328
CYC1 -4147 -4292
DNAJC19 1118 -4186
FXN -2179 -3293
GFER -3119 -1243
GRPEL1 -2346 -2045
GRPEL2 1127 1067
HSCB -134 -1814
HSPA9 2342 -3484
HSPD1 -855 -3145
IDH3G -4178 -3714
LDHD -5163 -2192
MTX1 2018 -1987
MTX2 52 -2397
NDUFB8 -3020 -4892
PAM16 -2464 -2969
PITRM1 582 -1790
PMPCA -92 -3017
PMPCB -832 -4741
SAMM50 1141 -4536
SLC25A12 -5347 -4761
SLC25A13 4283 2507
SLC25A4 -1327 -4427
TAZ -3604 -4956
TIMM10 179 -2702
TIMM10B 4307 -4902
TIMM13 -3591 -2117
TIMM17A 2548 -4167
TIMM17B -3141 -2749
TIMM21 1825 -4898
TIMM22 1561 -3223
TIMM44 -1151 -5068
TIMM50 987 -2561
TIMM8B -658 -3816
TIMM9 690 -3965
TOMM20 2711 101
TOMM22 2828 -2447
TOMM40 4211 -1560
TOMM5 2707 -4232
TOMM7 -1885 -3378
VDAC1 -2909 -4782



SUMOylation of DNA replication proteins

SUMOylation of DNA replication proteins
metric value
setSize 35
pMANOVA 9.54e-08
p.adjustMANOVA 1.81e-06
s.dist 0.597
s.human 0.499
s.mouse 0.329
p.human 3.3e-07
p.mouse 0.000768




Top 20 genes
Gene human mouse
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
TOP1 4805 3104
TOP2A 4691 3074
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
PCNA 1329 5271
NUP214 3124 1845
INCENP 3676 1455
SEH1L 1085 4110
RANGAP1 483 4468
NUP88 1244 1407
PIAS3 640 1976
UBE2I 1246 733

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
AURKA 3811 -2443
INCENP 3676 1455
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
PCNA 1329 5271
PIAS3 640 1976
PIAS4 342 -629
RAE1 4471 3078
RANBP2 4470 -562
RANGAP1 483 4468
SEC13 730 938
SEH1L 1085 4110
SUMO1 4213 -262
SUMO3 -2496 5007
TOP1 4805 3104
TOP2A 4691 3074
TOP2B 494 79
TPR 2984 275
UBE2I 1246 733



EGR2 and SOX10-mediated initiation of Schwann cell myelination

EGR2 and SOX10-mediated initiation of Schwann cell myelination
metric value
setSize 20
pMANOVA 2.65e-06
p.adjustMANOVA 2.84e-05
s.dist 0.594
s.human -0.423
s.mouse 0.417
p.human 0.00107
p.mouse 0.00125




Top 20 genes
Gene human mouse
NAB2 -5323 4380
SREBF2 -4703 4606
EGR2 -3746 5163
DAG1 -5236 3304
LAMC1 -3224 3688
TEAD1 -4292 2647
CYP51A1 -1716 5305
WWTR1 -2503 3401
NAB1 -3099 2676
DRP2 -4004 1540
LAMA2 -3799 1005
SMARCA4 -3874 863
YAP1 -476 5038
PMP22 -1291 940
PRX -2568 288
LAMB1 -457 829

Click HERE to show all gene set members

All member genes
human mouse
CYP51A1 -1716 5305
DAG1 -5236 3304
DRP2 -4004 1540
EGR2 -3746 5163
HDAC2 4386 -579
HMGCR 971 4993
LAMA2 -3799 1005
LAMB1 -457 829
LAMC1 -3224 3688
MBP -2415 -1118
NAB1 -3099 2676
NAB2 -5323 4380
PMP22 -1291 940
PRX -2568 288
SMARCA4 -3874 863
SREBF2 -4703 4606
TEAD1 -4292 2647
UTRN -3639 -373
WWTR1 -2503 3401
YAP1 -476 5038



NS1 Mediated Effects on Host Pathways

NS1 Mediated Effects on Host Pathways
metric value
setSize 31
pMANOVA 1.07e-06
p.adjustMANOVA 1.47e-05
s.dist 0.59
s.human 0.451
s.mouse 0.379
p.human 1.37e-05
p.mouse 0.00026




Top 20 genes
Gene human mouse
KPNA2 5007 4653
NUP98 4235 5486
NUP54 4508 4751
NUP153 4762 4031
NUP205 4438 3917
KPNB1 3619 4744
RAE1 4471 3078
NUP155 4306 2897
NUP35 4571 2515
NUP107 3232 3195
NUP188 2117 4593
NUP160 3998 2314
KPNA1 1833 4786
KPNA4 1501 5379
NUP214 3124 1845
SEH1L 1085 4110
CPSF4 862 4202
NUP88 1244 1407
NUP43 4562 193
TPR 2984 275

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40
CPSF4 862 4202
EIF2AK2 -486 -129
ISG15 -3928 -331
KPNA1 1833 4786
KPNA2 5007 4653
KPNA3 -2337 -979
KPNA4 1501 5379
KPNB1 3619 4744
NDC1 1273 -322
NUP107 3232 3195
NUP133 889 -2580
NUP153 4762 4031
NUP155 4306 2897
NUP160 3998 2314
NUP188 2117 4593
NUP205 4438 3917
NUP214 3124 1845
NUP35 4571 2515
NUP37 -327 -873
NUP43 4562 193
NUP54 4508 4751
NUP85 3181 227
NUP88 1244 1407
NUP93 -1503 5229
NUP98 4235 5486
RAE1 4471 3078
RANBP2 4470 -562
SEC13 730 938
SEH1L 1085 4110
TPR 2984 275



Metabolism of non-coding RNA

Metabolism of non-coding RNA
metric value
setSize 45
pMANOVA 4.91e-10
p.adjustMANOVA 1.38e-08
s.dist 0.588
s.human 0.556
s.mouse 0.192
p.human 1.1e-10
p.mouse 0.0258




Top 20 genes
Gene human mouse
NUP98 4235 5486.0
NUP54 4508 4751.0
NUP153 4762 4031.0
NUP205 4438 3917.0
RAE1 4471 3078.0
TGS1 4576 2855.0
NUP155 4306 2897.0
NUP35 4571 2515.0
NUP107 3232 3195.0
SNRPG 3179 3068.0
NUP188 2117 4593.0
GEMIN5 4699 2018.0
NUP160 3998 2314.0
DDX20 4951 1841.0
SMN1 4028 2156.5
SNRPD1 3996 1707.0
GEMIN7 2344 2502.0
NUP214 3124 1845.0
SNUPN 2836 1926.0
SEH1L 1085 4110.0

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40.0
CLNS1A 155 1480.0
DDX20 4951 1841.0
GEMIN2 3264 -1925.0
GEMIN5 4699 2018.0
GEMIN6 3429 314.0
GEMIN7 2344 2502.0
GEMIN8 94 1167.0
NCBP1 -1736 4720.0
NCBP2 4188 -2519.0
NDC1 1273 -322.0
NUP107 3232 3195.0
NUP133 889 -2580.0
NUP153 4762 4031.0
NUP155 4306 2897.0
NUP160 3998 2314.0
NUP188 2117 4593.0
NUP205 4438 3917.0
NUP214 3124 1845.0
NUP35 4571 2515.0
NUP37 -327 -873.0
NUP43 4562 193.0
NUP54 4508 4751.0
NUP85 3181 227.0
NUP88 1244 1407.0
NUP93 -1503 5229.0
NUP98 4235 5486.0
PHAX 4729 -485.0
PRMT5 933 2092.0
RAE1 4471 3078.0
RANBP2 4470 -562.0
SEC13 730 938.0
SEH1L 1085 4110.0
SMN1 4028 2156.5
SNRPB 3761 -2577.0
SNRPD1 3996 1707.0
SNRPD2 2043 -2933.0
SNRPD3 2384 -3590.0
SNRPE 3421 -1387.0
SNRPF 3777 -2345.0
SNRPG 3179 3068.0
SNUPN 2836 1926.0
TGS1 4576 2855.0
TPR 2984 275.0
WDR77 -799 -1323.0



snRNP Assembly

snRNP Assembly
metric value
setSize 45
pMANOVA 4.91e-10
p.adjustMANOVA 1.38e-08
s.dist 0.588
s.human 0.556
s.mouse 0.192
p.human 1.1e-10
p.mouse 0.0258




Top 20 genes
Gene human mouse
NUP98 4235 5486.0
NUP54 4508 4751.0
NUP153 4762 4031.0
NUP205 4438 3917.0
RAE1 4471 3078.0
TGS1 4576 2855.0
NUP155 4306 2897.0
NUP35 4571 2515.0
NUP107 3232 3195.0
SNRPG 3179 3068.0
NUP188 2117 4593.0
GEMIN5 4699 2018.0
NUP160 3998 2314.0
DDX20 4951 1841.0
SMN1 4028 2156.5
SNRPD1 3996 1707.0
GEMIN7 2344 2502.0
NUP214 3124 1845.0
SNUPN 2836 1926.0
SEH1L 1085 4110.0

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 40.0
CLNS1A 155 1480.0
DDX20 4951 1841.0
GEMIN2 3264 -1925.0
GEMIN5 4699 2018.0
GEMIN6 3429 314.0
GEMIN7 2344 2502.0
GEMIN8 94 1167.0
NCBP1 -1736 4720.0
NCBP2 4188 -2519.0
NDC1 1273 -322.0
NUP107 3232 3195.0
NUP133 889 -2580.0
NUP153 4762 4031.0
NUP155 4306 2897.0
NUP160 3998 2314.0
NUP188 2117 4593.0
NUP205 4438 3917.0
NUP214 3124 1845.0
NUP35 4571 2515.0
NUP37 -327 -873.0
NUP43 4562 193.0
NUP54 4508 4751.0
NUP85 3181 227.0
NUP88 1244 1407.0
NUP93 -1503 5229.0
NUP98 4235 5486.0
PHAX 4729 -485.0
PRMT5 933 2092.0
RAE1 4471 3078.0
RANBP2 4470 -562.0
SEC13 730 938.0
SEH1L 1085 4110.0
SMN1 4028 2156.5
SNRPB 3761 -2577.0
SNRPD1 3996 1707.0
SNRPD2 2043 -2933.0
SNRPD3 2384 -3590.0
SNRPE 3421 -1387.0
SNRPF 3777 -2345.0
SNRPG 3179 3068.0
SNUPN 2836 1926.0
TGS1 4576 2855.0
TPR 2984 275.0
WDR77 -799 -1323.0



Regulation of pyruvate dehydrogenase (PDH) complex

Regulation of pyruvate dehydrogenase (PDH) complex
metric value
setSize 15
pMANOVA 0.000696
p.adjustMANOVA 0.00386
s.dist 0.588
s.human -0.162
s.mouse -0.565
p.human 0.277
p.mouse 0.000151




Top 20 genes
Gene human mouse
PDK2 -5450 -4464
PDHA1 -2405 -4692
GSTZ1 -2068 -5077
PDP2 -2619 -3350
DLAT -1960 -4426
PDP1 -2175 -3641
PDK4 -712 -4300
PDPR -632 -3822
PDHB -133 -4587
PDHX -126 -4448

Click HERE to show all gene set members

All member genes
human mouse
DLAT -1960 -4426
DLD 1187 -4834
GSTZ1 -2068 -5077
PDHA1 -2405 -4692
PDHB -133 -4587
PDHX -126 -4448
PDK1 4600 -3535
PDK2 -5450 -4464
PDK3 4747 5315
PDK4 -712 -4300
PDP1 -2175 -3641
PDP2 -2619 -3350
PDPR -632 -3822
PPARD -4213 2330
RXRA -5519 1619



Branched-chain amino acid catabolism

Branched-chain amino acid catabolism
metric value
setSize 20
pMANOVA 4.02e-05
p.adjustMANOVA 0.000313
s.dist 0.585
s.human -0.0744
s.mouse -0.581
p.human 0.565
p.mouse 6.99e-06




Top 20 genes
Gene human mouse
BCKDK -4693 -4582
IVD -4805 -4233
ECHS1 -3895 -4648
HIBADH -4032 -4229
BCKDHB -4241 -2970
BCAT2 -4182 -2507
ALDH6A1 -1396 -4986
ACAD8 -1259 -4572
AUH -1294 -4152
HSD17B10 -1193 -1970

Click HERE to show all gene set members

All member genes
human mouse
ACAD8 -1259 -4572
ACADSB 3088 -4198
ACAT1 470 -4325
ALDH6A1 -1396 -4986
AUH -1294 -4152
BCAT1 -3549 4562
BCAT2 -4182 -2507
BCKDHB -4241 -2970
BCKDK -4693 -4582
DBT 2001 5426
DLD 1187 -4834
ECHS1 -3895 -4648
HIBADH -4032 -4229
HIBCH 488 -4841
HSD17B10 -1193 -1970
IVD -4805 -4233
MCCC1 4013 -4623
MCCC2 2204 -4951
PPM1K 2278 -4721
SLC25A44 4847 3872



Role of LAT2/NTAL/LAB on calcium mobilization

Role of LAT2/NTAL/LAB on calcium mobilization
metric value
setSize 11
pMANOVA 0.00639
p.adjustMANOVA 0.0253
s.dist 0.579
s.human 0.2
s.mouse 0.543
p.human 0.25
p.mouse 0.0018




Top 20 genes
Gene human mouse
SHC1 3976 4815
PIK3CB 2760 5125
PDPK1 3443 3947
GAB2 4053 2415
LYN 785 2842
PIK3CA 365 4218

Click HERE to show all gene set members

All member genes
human mouse
FYN -2850 4537
GAB2 4053 2415
GRB2 -4050 3027
LAT2 -1020 1710
LYN 785 2842
PDPK1 3443 3947
PIK3CA 365 4218
PIK3CB 2760 5125
PIK3R1 2896 -813
SHC1 3976 4815
SOS1 -1962 2326



GPVI-mediated activation cascade

GPVI-mediated activation cascade
metric value
setSize 18
pMANOVA 0.000217
p.adjustMANOVA 0.00143
s.dist 0.578
s.human 0.159
s.mouse 0.556
p.human 0.242
p.mouse 4.47e-05




Top 20 genes
Gene human mouse
RHOB 4609 4443
PIK3CB 2760 5125
PDPK1 3443 3947
PIK3R3 3188 3545
CDC42 3308 965
LYN 785 2842
RHOA 539 4106
PIK3CA 365 4218
RAC2 41 4138

Click HERE to show all gene set members

All member genes
human mouse
CDC42 3308 965
FYN -2850 4537
LYN 785 2842
PDPK1 3443 3947
PDPN -3304 5189
PIK3CA 365 4218
PIK3CB 2760 5125
PIK3R1 2896 -813
PIK3R3 3188 3545
PTPN11 -1575 3105
PTPN6 -931 4180
RAC1 2525 -240
RAC2 41 4138
RHOA 539 4106
RHOB 4609 4443
RHOG -1207 5167
VAV2 -4959 2847
VAV3 187 -276



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] ggplot2_3.3.2               reshape2_1.4.4             
##  [5] beeswarm_0.2.3              gplots_3.1.0               
##  [7] gtools_3.8.2                tibble_3.0.4               
##  [9] dplyr_1.0.2                 echarts4r_0.3.3            
## [11] DESeq2_1.28.1               SummarizedExperiment_1.18.2
## [13] DelayedArray_0.14.1         matrixStats_0.57.0         
## [15] Biobase_2.48.0              GenomicRanges_1.40.0       
## [17] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [19] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [21] mitch_1.0.10               
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_4.0.5            RColorBrewer_1.1-2    
##  [4] rprojroot_1.3-2        tools_4.0.2            backports_1.1.10      
##  [7] R6_2.4.1               KernSmooth_2.23-17     DBI_1.1.0             
## [10] colorspace_1.4-1       withr_2.3.0            tidyselect_1.1.0      
## [13] gridExtra_2.3          bit_4.0.4              compiler_4.0.2        
## [16] desc_1.2.0             labeling_0.4.2         caTools_1.18.0        
## [19] scales_1.1.1           genefilter_1.70.0      stringr_1.4.0         
## [22] digest_0.6.26          rmarkdown_2.5          XVector_0.28.0        
## [25] pkgconfig_2.0.3        htmltools_0.5.0        highr_0.8             
## [28] fastmap_1.0.1          htmlwidgets_1.5.2      rlang_0.4.8           
## [31] RSQLite_2.2.1          shiny_1.5.0            generics_0.0.2        
## [34] farver_2.0.3           jsonlite_1.7.1         BiocParallel_1.22.0   
## [37] RCurl_1.98-1.2         magrittr_1.5           GenomeInfoDbData_1.2.3
## [40] Matrix_1.2-18          Rcpp_1.0.5             munsell_0.5.0         
## [43] lifecycle_0.2.0        stringi_1.5.3          yaml_2.2.1            
## [46] MASS_7.3-53            zlibbioc_1.34.0        plyr_1.8.6            
## [49] grid_4.0.2             blob_1.2.1             promises_1.1.1        
## [52] crayon_1.3.4           lattice_0.20-41        splines_4.0.2         
## [55] annotate_1.66.0        locfit_1.5-9.4         knitr_1.30            
## [58] pillar_1.4.6           geneplotter_1.66.0     XML_3.99-0.5          
## [61] glue_1.4.2             evaluate_0.14          vctrs_0.3.4           
## [64] httpuv_1.5.4           testthat_2.3.2         gtable_0.3.0          
## [67] purrr_0.3.4            reshape_0.8.8          assertthat_0.2.1      
## [70] xfun_0.18              mime_0.9               xtable_1.8-4          
## [73] later_1.1.0.1          survival_3.2-7         AnnotationDbi_1.50.3  
## [76] memoise_1.1.0          ellipsis_0.3.1

END of report