date generated: 2022-05-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##            metric
## PCDHGA3 -18.78633
## PCDHGA1 -17.90155
## PCDHGA2 -17.82102
## PCDHGB1 -19.03550
## PCDHGA4 -18.61454
## PCDHGB2 -18.19514
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 20094
duplicated_genes_present 0
num_profile_genes_in_sets 9720
num_profile_genes_not_in_sets 10374

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1026
num_genesets_included 1520

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.82e-04 -0.591 2.39e-03
SLBP independent Processing of Histone Pre-mRNAs 10 1.28e-03 -0.588 4.10e-03
Resolution of D-Loop Structures 26 7.45e-07 -0.561 7.30e-06
Pexophagy 11 1.34e-03 -0.558 4.23e-03
Resolution of D-loop Structures through Holliday Junction Intermediates 25 1.35e-06 -0.558 1.17e-05
Activation of the phototransduction cascade 11 1.41e-03 0.556 4.42e-03
Expression and translocation of olfactory receptors 331 3.74e-65 0.543 1.89e-62
Creation of C4 and C2 activators 14 4.40e-04 0.542 1.62e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 20 2.72e-05 -0.542 1.44e-04
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 20 2.72e-05 -0.542 1.44e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 20 2.72e-05 -0.542 1.44e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 20 2.72e-05 -0.542 1.44e-04
Impaired BRCA2 binding to PALB2 20 2.72e-05 -0.542 1.44e-04
Condensation of Prometaphase Chromosomes 11 1.94e-03 -0.539 5.79e-03
Olfactory Signaling Pathway 338 2.95e-65 0.538 1.89e-62
SARS-CoV-2 modulates autophagy 11 2.33e-03 -0.530 6.80e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 22 1.79e-05 -0.528 1.02e-04
Fatty acids 15 4.56e-04 0.523 1.66e-03
RNA Polymerase II Transcription Termination 50 3.09e-10 -0.514 6.90e-09
Impaired BRCA2 binding to RAD51 31 8.02e-07 -0.512 7.77e-06
mRNA 3’-end processing 41 1.71e-08 -0.509 2.55e-07
ALK mutants bind TKIs 12 2.48e-03 -0.504 7.11e-03
Reversible hydration of carbon dioxide 11 3.79e-03 0.504 1.03e-02
Sodium/Calcium exchangers 10 6.09e-03 0.501 1.55e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.58e-04 -0.500 1.38e-03
HDR through MMEJ (alt-NHEJ) 11 4.10e-03 -0.500 1.10e-02
Aspirin ADME 41 3.31e-08 0.498 4.75e-07
TICAM1, RIP1-mediated IKK complex recruitment 18 2.67e-04 -0.496 1.05e-03
Miscellaneous substrates 12 2.95e-03 0.495 8.25e-03
Transport of the SLBP Dependant Mature mRNA 32 1.29e-06 -0.494 1.12e-05
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.48e-03 -0.491 4.61e-03
Transport of the SLBP independent Mature mRNA 31 2.31e-06 -0.490 1.85e-05
Class C/3 (Metabotropic glutamate/pheromone receptors) 35 5.32e-07 0.490 5.72e-06
Spry regulation of FGF signaling 16 6.97e-04 -0.490 2.42e-03
Processing of Capped Intronless Pre-mRNA 28 7.71e-06 -0.488 4.97e-05
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 5.36e-10 -0.488 1.16e-08
TICAM1-dependent activation of IRF3/IRF7 12 3.85e-03 -0.482 1.04e-02
Export of Viral Ribonucleoproteins from Nucleus 30 5.31e-06 -0.480 3.60e-05
Initial triggering of complement 21 1.41e-04 0.480 5.86e-04
Folding of actin by CCT/TriC 10 8.94e-03 -0.477 2.20e-02
Nuclear Pore Complex (NPC) Disassembly 33 2.18e-06 -0.476 1.75e-05
Metabolism of non-coding RNA 48 1.54e-08 -0.472 2.32e-07
snRNP Assembly 48 1.54e-08 -0.472 2.32e-07
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 32 3.92e-06 -0.471 2.85e-05
Transport of Mature Transcript to Cytoplasm 63 9.94e-11 -0.471 2.65e-09
mRNA decay by 5’ to 3’ exoribonuclease 15 1.67e-03 -0.469 5.11e-03
FGFR2 alternative splicing 25 5.24e-05 -0.467 2.49e-04
Processing of Intronless Pre-mRNAs 19 4.54e-04 -0.465 1.66e-03
p75NTR recruits signalling complexes 12 5.36e-03 -0.464 1.39e-02
Removal of the Flap Intermediate from the C-strand 17 9.40e-04 -0.463 3.15e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.82e-04 -0.591000 2.39e-03
SLBP independent Processing of Histone Pre-mRNAs 10 1.28e-03 -0.588000 4.10e-03
Resolution of D-Loop Structures 26 7.45e-07 -0.561000 7.30e-06
Pexophagy 11 1.34e-03 -0.558000 4.23e-03
Resolution of D-loop Structures through Holliday Junction Intermediates 25 1.35e-06 -0.558000 1.17e-05
Activation of the phototransduction cascade 11 1.41e-03 0.556000 4.42e-03
Expression and translocation of olfactory receptors 331 3.74e-65 0.543000 1.89e-62
Creation of C4 and C2 activators 14 4.40e-04 0.542000 1.62e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 20 2.72e-05 -0.542000 1.44e-04
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 20 2.72e-05 -0.542000 1.44e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 20 2.72e-05 -0.542000 1.44e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 20 2.72e-05 -0.542000 1.44e-04
Impaired BRCA2 binding to PALB2 20 2.72e-05 -0.542000 1.44e-04
Condensation of Prometaphase Chromosomes 11 1.94e-03 -0.539000 5.79e-03
Olfactory Signaling Pathway 338 2.95e-65 0.538000 1.89e-62
SARS-CoV-2 modulates autophagy 11 2.33e-03 -0.530000 6.80e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 22 1.79e-05 -0.528000 1.02e-04
Fatty acids 15 4.56e-04 0.523000 1.66e-03
RNA Polymerase II Transcription Termination 50 3.09e-10 -0.514000 6.90e-09
Impaired BRCA2 binding to RAD51 31 8.02e-07 -0.512000 7.77e-06
mRNA 3’-end processing 41 1.71e-08 -0.509000 2.55e-07
ALK mutants bind TKIs 12 2.48e-03 -0.504000 7.11e-03
Reversible hydration of carbon dioxide 11 3.79e-03 0.504000 1.03e-02
Sodium/Calcium exchangers 10 6.09e-03 0.501000 1.55e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.58e-04 -0.500000 1.38e-03
HDR through MMEJ (alt-NHEJ) 11 4.10e-03 -0.500000 1.10e-02
Aspirin ADME 41 3.31e-08 0.498000 4.75e-07
TICAM1, RIP1-mediated IKK complex recruitment 18 2.67e-04 -0.496000 1.05e-03
Miscellaneous substrates 12 2.95e-03 0.495000 8.25e-03
Transport of the SLBP Dependant Mature mRNA 32 1.29e-06 -0.494000 1.12e-05
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.48e-03 -0.491000 4.61e-03
Transport of the SLBP independent Mature mRNA 31 2.31e-06 -0.490000 1.85e-05
Class C/3 (Metabotropic glutamate/pheromone receptors) 35 5.32e-07 0.490000 5.72e-06
Spry regulation of FGF signaling 16 6.97e-04 -0.490000 2.42e-03
Processing of Capped Intronless Pre-mRNA 28 7.71e-06 -0.488000 4.97e-05
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 5.36e-10 -0.488000 1.16e-08
TICAM1-dependent activation of IRF3/IRF7 12 3.85e-03 -0.482000 1.04e-02
Export of Viral Ribonucleoproteins from Nucleus 30 5.31e-06 -0.480000 3.60e-05
Initial triggering of complement 21 1.41e-04 0.480000 5.86e-04
Folding of actin by CCT/TriC 10 8.94e-03 -0.477000 2.20e-02
Nuclear Pore Complex (NPC) Disassembly 33 2.18e-06 -0.476000 1.75e-05
Metabolism of non-coding RNA 48 1.54e-08 -0.472000 2.32e-07
snRNP Assembly 48 1.54e-08 -0.472000 2.32e-07
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 32 3.92e-06 -0.471000 2.85e-05
Transport of Mature Transcript to Cytoplasm 63 9.94e-11 -0.471000 2.65e-09
mRNA decay by 5’ to 3’ exoribonuclease 15 1.67e-03 -0.469000 5.11e-03
FGFR2 alternative splicing 25 5.24e-05 -0.467000 2.49e-04
Processing of Intronless Pre-mRNAs 19 4.54e-04 -0.465000 1.66e-03
p75NTR recruits signalling complexes 12 5.36e-03 -0.464000 1.39e-02
Removal of the Flap Intermediate from the C-strand 17 9.40e-04 -0.463000 3.15e-03
NEP/NS2 Interacts with the Cellular Export Machinery 29 1.64e-05 -0.462000 9.53e-05
Digestion 20 3.66e-04 0.460000 1.39e-03
HDR through Homologous Recombination (HRR) 58 1.34e-09 -0.460000 2.58e-08
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.04e-03 -0.459000 3.47e-03
NRIF signals cell death from the nucleus 16 1.50e-03 -0.458000 4.64e-03
Mitochondrial tRNA aminoacylation 18 7.62e-04 -0.458000 2.64e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 39 7.82e-07 -0.457000 7.62e-06
Keratinization 201 5.58e-29 0.457000 8.48e-27
ERKs are inactivated 13 4.48e-03 -0.455000 1.19e-02
Recycling of bile acids and salts 16 1.71e-03 0.453000 5.21e-03
Transport of Mature mRNA Derived from an Intronless Transcript 38 1.37e-06 -0.453000 1.18e-05
Deadenylation of mRNA 24 1.29e-04 -0.451000 5.41e-04
Citric acid cycle (TCA cycle) 21 3.64e-04 -0.449000 1.39e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 35 4.24e-06 -0.449000 3.01e-05
Diseases of DNA Double-Strand Break Repair 35 4.24e-06 -0.449000 3.01e-05
Cleavage of the damaged purine 11 1.00e-02 -0.448000 2.42e-02
Depurination 11 1.00e-02 -0.448000 2.42e-02
Recognition and association of DNA glycosylase with site containing an affected purine 11 1.00e-02 -0.448000 2.42e-02
tRNA Aminoacylation 24 1.50e-04 -0.447000 6.16e-04
MAPK targets/ Nuclear events mediated by MAP kinases 29 3.34e-05 -0.445000 1.70e-04
Deposition of new CENPA-containing nucleosomes at the centromere 21 4.19e-04 -0.445000 1.56e-03
Nucleosome assembly 21 4.19e-04 -0.445000 1.56e-03
ISG15 antiviral mechanism 70 1.24e-10 -0.445000 3.18e-09
Sensory Perception 534 9.23e-69 0.442000 1.40e-65
Nuclear import of Rev protein 31 2.29e-05 -0.439000 1.26e-04
Presynaptic phase of homologous DNA pairing and strand exchange 34 9.95e-06 -0.438000 6.17e-05
NF-kB is activated and signals survival 12 8.74e-03 -0.437000 2.16e-02
Interleukin-6 signaling 11 1.21e-02 -0.437000 2.86e-02
Regulation of TP53 Activity through Methylation 16 2.50e-03 -0.436000 7.13e-03
CYP2E1 reactions 11 1.23e-02 0.436000 2.89e-02
Metabolism of amine-derived hormones 17 1.88e-03 0.435000 5.64e-03
Diseases associated with visual transduction 11 1.29e-02 0.433000 3.00e-02
Diseases of the neuronal system 11 1.29e-02 0.433000 3.00e-02
Retinoid cycle disease events 11 1.29e-02 0.433000 3.00e-02
Antiviral mechanism by IFN-stimulated genes 77 5.43e-11 -0.432000 1.53e-09
Vpr-mediated nuclear import of PICs 31 3.82e-05 -0.427000 1.91e-04
RUNX3 regulates p14-ARF 10 1.95e-02 -0.427000 4.34e-02
Interactions of Rev with host cellular proteins 34 1.67e-05 -0.426000 9.61e-05
Deadenylation-dependent mRNA decay 54 6.00e-08 -0.426000 8.44e-07
Xenobiotics 24 3.03e-04 0.426000 1.18e-03
Transport of Ribonucleoproteins into the Host Nucleus 29 7.24e-05 -0.426000 3.28e-04
Interactions of Vpr with host cellular proteins 32 3.36e-05 -0.424000 1.71e-04
Common Pathway of Fibrin Clot Formation 21 8.01e-04 0.422000 2.73e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste 39 4.97e-06 0.422000 3.45e-05
Signaling by CSF3 (G-CSF) 28 1.12e-04 -0.422000 4.83e-04
Antimicrobial peptides 70 1.06e-09 0.421000 2.10e-08
SUMOylation of ubiquitinylation proteins 36 1.22e-05 -0.421000 7.38e-05
Rev-mediated nuclear export of HIV RNA 32 3.87e-05 -0.420000 1.91e-04
Transcriptional regulation by small RNAs 43 1.89e-06 -0.420000 1.58e-05
SARS-CoV-2 modulates host translation machinery 45 1.10e-06 -0.420000 9.98e-06
Regulation of innate immune responses to cytosolic DNA 14 6.56e-03 -0.420000 1.66e-02
ERK/MAPK targets 20 1.16e-03 -0.419000 3.82e-03
Processive synthesis on the C-strand of the telomere 19 1.58e-03 -0.419000 4.87e-03
Viral Messenger RNA Synthesis 41 3.53e-06 -0.418000 2.62e-05
p75NTR signals via NF-kB 15 5.02e-03 -0.418000 1.32e-02
HDR through Single Strand Annealing (SSA) 34 2.71e-05 -0.416000 1.44e-04
Processing of Capped Intron-Containing Pre-mRNA 209 5.98e-25 -0.414000 6.99e-23
Initiation of Nuclear Envelope (NE) Reformation 18 2.43e-03 -0.413000 7.00e-03
Inhibition of DNA recombination at telomere 20 1.44e-03 -0.412000 4.50e-03
Intrinsic Pathway of Fibrin Clot Formation 21 1.11e-03 0.411000 3.68e-03
Homologous DNA Pairing and Strand Exchange 37 1.51e-05 -0.411000 8.91e-05
SUMOylation of SUMOylation proteins 32 5.89e-05 -0.410000 2.71e-04
The canonical retinoid cycle in rods (twilight vision) 23 6.60e-04 0.410000 2.33e-03
tRNA processing in the nucleus 53 2.78e-07 -0.408000 3.24e-06
Hormone ligand-binding receptors 13 1.09e-02 0.408000 2.61e-02
mRNA Splicing - Major Pathway 155 3.31e-18 -0.405000 2.19e-16
Metalloprotease DUBs 18 2.98e-03 -0.404000 8.30e-03
Translesion Synthesis by POLH 18 3.09e-03 -0.403000 8.56e-03
Inactivation of CSF3 (G-CSF) signaling 23 8.56e-04 -0.401000 2.91e-03
Synthesis of glycosylphosphatidylinositol (GPI) 17 4.25e-03 -0.400000 1.13e-02
E3 ubiquitin ligases ubiquitinate target proteins 42 7.13e-06 -0.400000 4.69e-05
Scavenging of heme from plasma 11 2.20e-02 0.399000 4.82e-02
Hh mutants abrogate ligand secretion 57 1.91e-07 -0.399000 2.32e-06
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.22e-02 -0.398000 4.83e-02
Diseases of DNA repair 45 3.84e-06 -0.398000 2.82e-05
Biotin transport and metabolism 10 2.95e-02 -0.397000 6.06e-02
ER Quality Control Compartment (ERQC) 20 2.15e-03 -0.396000 6.32e-03
Stabilization of p53 55 3.98e-07 -0.395000 4.44e-06
Abortive elongation of HIV-1 transcript in the absence of Tat 19 2.93e-03 -0.394000 8.21e-03
Nonhomologous End-Joining (NHEJ) 30 1.88e-04 -0.394000 7.57e-04
mRNA Splicing - Minor Pathway 48 2.40e-06 -0.393000 1.90e-05
Beta defensins 28 3.15e-04 0.393000 1.22e-03
mRNA Splicing 165 2.73e-18 -0.393000 1.89e-16
Mitochondrial translation 92 6.99e-11 -0.393000 1.90e-09
Sensory perception of taste 45 5.28e-06 0.392000 3.60e-05
Glycogen synthesis 15 8.57e-03 -0.392000 2.12e-02
Defensins 36 4.72e-05 0.392000 2.28e-04
RIPK1-mediated regulated necrosis 27 4.26e-04 -0.392000 1.58e-03
Regulation of necroptotic cell death 27 4.26e-04 -0.392000 1.58e-03
Defects in vitamin and cofactor metabolism 20 2.42e-03 -0.392000 6.99e-03
Zinc influx into cells by the SLC39 gene family 10 3.20e-02 -0.392000 6.47e-02
Formation of the cornified envelope 69 2.01e-08 0.390000 2.95e-07
IKK complex recruitment mediated by RIP1 22 1.56e-03 -0.390000 4.81e-03
Serotonin receptors 11 2.55e-02 0.389000 5.37e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 3.42e-03 -0.388000 9.36e-03
Respiratory electron transport 81 1.58e-09 -0.388000 2.97e-08
NS1 Mediated Effects on Host Pathways 38 3.68e-05 -0.387000 1.85e-04
Eicosanoids 12 2.04e-02 0.387000 4.50e-02
SUMOylation of RNA binding proteins 44 9.08e-06 -0.387000 5.75e-05
Hh mutants are degraded by ERAD 54 8.88e-07 -0.387000 8.38e-06
Thyroxine biosynthesis 10 3.44e-02 0.386000 6.85e-02
HCMV Early Events 54 9.25e-07 -0.386000 8.68e-06
Degradation of cysteine and homocysteine 14 1.24e-02 -0.386000 2.92e-02
Mitochondrial translation termination 86 6.96e-10 -0.385000 1.49e-08
Negative regulation of NOTCH4 signaling 52 1.72e-06 -0.383000 1.45e-05
Formation of Fibrin Clot (Clotting Cascade) 37 5.46e-05 0.383000 2.58e-04
Mitochondrial translation initiation 86 8.34e-10 -0.383000 1.76e-08
HDACs deacetylate histones 29 3.71e-04 -0.382000 1.41e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 29 3.83e-04 -0.381000 1.44e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 29 3.83e-04 -0.381000 1.44e-03
Translation 262 2.42e-26 -0.381000 3.07e-24
ZBP1(DAI) mediated induction of type I IFNs 20 3.27e-03 -0.380000 8.99e-03
Josephin domain DUBs 11 2.92e-02 -0.380000 6.02e-02
G2/M DNA damage checkpoint 55 1.11e-06 -0.380000 1.00e-05
tRNA processing 90 4.92e-10 -0.379000 1.08e-08
Nitric oxide stimulates guanylate cyclase 22 2.11e-03 0.379000 6.19e-03
Resolution of Sister Chromatid Cohesion 95 1.87e-10 -0.378000 4.52e-09
Condensation of Prophase Chromosomes 12 2.34e-02 -0.378000 5.02e-02
Base-Excision Repair, AP Site Formation 18 5.51e-03 -0.378000 1.42e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 50 4.04e-06 -0.377000 2.90e-05
TNF signaling 37 7.44e-05 -0.376000 3.35e-04
Formation of RNA Pol II elongation complex 49 5.41e-06 -0.375000 3.62e-05
RNA Polymerase II Transcription Elongation 49 5.41e-06 -0.375000 3.62e-05
HATs acetylate histones 59 6.06e-07 -0.375000 6.21e-06
Mitochondrial translation elongation 86 1.85e-09 -0.375000 3.37e-08
Diseases associated with N-glycosylation of proteins 19 4.70e-03 -0.375000 1.24e-02
Mitotic Prophase 75 2.02e-08 -0.375000 2.95e-07
Activation of the AP-1 family of transcription factors 10 4.05e-02 -0.374000 7.84e-02
Autodegradation of the E3 ubiquitin ligase COP1 50 5.18e-06 -0.372000 3.58e-05
Transcription of E2F targets under negative control by DREAM complex 19 4.94e-03 -0.372000 1.30e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 1.61e-02 0.372000 3.65e-02
Diseases of hemostasis 14 1.61e-02 0.372000 3.65e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 8.00e-03 -0.371000 2.00e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.79e-04 -0.371000 2.38e-03
Cleavage of the damaged pyrimidine 16 1.03e-02 -0.371000 2.47e-02
Depyrimidination 16 1.03e-02 -0.371000 2.47e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 1.03e-02 -0.371000 2.47e-02
DNA Damage Recognition in GG-NER 36 1.21e-04 -0.370000 5.13e-04
HDMs demethylate histones 17 8.28e-03 -0.370000 2.05e-02
RNA Polymerase II Pre-transcription Events 69 1.07e-07 -0.370000 1.40e-06
Regulation of TNFR1 signaling 31 3.64e-04 -0.370000 1.39e-03
Homology Directed Repair 92 9.04e-10 -0.369000 1.88e-08
DNA Double-Strand Break Repair 121 2.30e-12 -0.369000 7.77e-11
Association of TriC/CCT with target proteins during biosynthesis 38 8.53e-05 -0.368000 3.80e-04
Nucleotide-like (purinergic) receptors 13 2.15e-02 0.368000 4.74e-02
O-glycosylation of TSR domain-containing proteins 35 1.66e-04 0.368000 6.73e-04
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.49e-03 -0.367000 4.64e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 44 2.57e-05 -0.367000 1.39e-04
EML4 and NUDC in mitotic spindle formation 90 1.86e-09 -0.366000 3.37e-08
Leading Strand Synthesis 13 2.23e-02 -0.366000 4.83e-02
Polymerase switching 13 2.23e-02 -0.366000 4.83e-02
Paracetamol ADME 29 6.44e-04 0.366000 2.28e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 1.19e-04 -0.366000 5.06e-04
Pausing and recovery of Tat-mediated HIV elongation 23 2.41e-03 -0.366000 6.96e-03
Tat-mediated HIV elongation arrest and recovery 23 2.41e-03 -0.366000 6.96e-03
RIP-mediated NFkB activation via ZBP1 16 1.14e-02 -0.365000 2.71e-02
Hedgehog ligand biogenesis 63 5.82e-07 -0.364000 6.06e-06
Acetylcholine binding and downstream events 14 1.84e-02 0.364000 4.14e-02
Postsynaptic nicotinic acetylcholine receptors 14 1.84e-02 0.364000 4.14e-02
Negative regulation of FLT3 15 1.47e-02 -0.364000 3.39e-02
CASP8 activity is inhibited 11 3.69e-02 -0.363000 7.26e-02
Dimerization of procaspase-8 11 3.69e-02 -0.363000 7.26e-02
Regulation by c-FLIP 11 3.69e-02 -0.363000 7.26e-02
Signaling by Activin 15 1.50e-02 -0.362000 3.45e-02
Regulation of TP53 Degradation 36 1.68e-04 -0.362000 6.83e-04
Host Interactions of HIV factors 121 6.36e-12 -0.361000 2.01e-10
mTORC1-mediated signalling 18 7.94e-03 -0.361000 1.99e-02
Processing of DNA double-strand break ends 58 1.93e-06 -0.361000 1.60e-05
SUMOylation of DNA replication proteins 43 4.14e-05 -0.361000 2.02e-04
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 86 7.03e-09 -0.361000 1.12e-07
Amplification of signal from the kinetochores 86 7.03e-09 -0.361000 1.12e-07
Metabolism of RNA 600 1.32e-51 -0.361000 5.03e-49
G2/M Checkpoints 119 1.12e-11 -0.360000 3.39e-10
Tandem pore domain potassium channels 12 3.08e-02 0.360000 6.31e-02
Digestion and absorption 25 1.84e-03 0.360000 5.55e-03
Defects in cobalamin (B12) metabolism 12 3.09e-02 -0.360000 6.31e-02
Regulation of TP53 Expression and Degradation 37 1.52e-04 -0.360000 6.21e-04
Base Excision Repair 45 2.97e-05 -0.360000 1.56e-04
Autodegradation of Cdh1 by Cdh1:APC/C 60 1.44e-06 -0.360000 1.23e-05
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 12 3.11e-02 -0.359000 6.32e-02
Glucuronidation 23 2.86e-03 0.359000 8.03e-03
Defective B3GALTL causes PpS 34 2.95e-04 0.359000 1.15e-03
Reduction of cytosolic Ca++ levels 11 3.95e-02 0.358000 7.71e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 87 7.44e-09 -0.358000 1.18e-07
The role of GTSE1 in G2/M progression after G2 checkpoint 58 2.38e-06 -0.358000 1.90e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.77e-05 -0.358000 1.01e-04
Termination of translesion DNA synthesis 31 5.66e-04 -0.358000 2.03e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 86 9.77e-09 -0.358000 1.53e-07
Gap junction assembly 18 8.64e-03 0.357000 2.14e-02
DNA Double Strand Break Response 41 7.49e-05 -0.357000 3.37e-04
SRP-dependent cotranslational protein targeting to membrane 105 2.73e-10 -0.356000 6.19e-09
Aggrephagy 23 3.08e-03 -0.356000 8.56e-03
Ubiquitin-dependent degradation of Cyclin D 50 1.30e-05 -0.356000 7.83e-05
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 86 1.11e-08 -0.356000 1.72e-07
Mitotic Prometaphase 163 4.16e-15 -0.356000 2.18e-13
Cell Cycle Checkpoints 233 7.26e-21 -0.356000 6.49e-19
Interaction between L1 and Ankyrins 28 1.11e-03 0.356000 3.68e-03
Separation of Sister Chromatids 156 1.65e-14 -0.356000 8.09e-13
SCF(Skp2)-mediated degradation of p27/p21 58 2.91e-06 -0.355000 2.26e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 106 2.70e-10 -0.355000 6.19e-09
Nonsense-Mediated Decay (NMD) 106 2.70e-10 -0.355000 6.19e-09
Cyclin A/B1/B2 associated events during G2/M transition 24 2.61e-03 -0.355000 7.40e-03
Endosomal/Vacuolar pathway 10 5.20e-02 -0.355000 9.68e-02
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 4.17e-02 0.355000 8.04e-02
MASTL Facilitates Mitotic Progression 10 5.25e-02 -0.354000 9.72e-02
tRNA modification in the nucleus and cytosol 33 4.34e-04 -0.354000 1.60e-03
Regulated proteolysis of p75NTR 11 4.25e-02 -0.353000 8.18e-02
Polymerase switching on the C-strand of the telomere 22 4.14e-03 -0.353000 1.11e-02
Complex I biogenesis 44 5.16e-05 -0.353000 2.46e-04
COPI-dependent Golgi-to-ER retrograde traffic 80 4.95e-08 -0.353000 7.03e-07
KSRP (KHSRP) binds and destabilizes mRNA 17 1.19e-02 -0.352000 2.83e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 1.48e-02 -0.352000 3.40e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 9.65e-06 -0.351000 6.02e-05
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.59e-03 -0.351000 4.87e-03
Mitotic Spindle Checkpoint 101 1.08e-09 -0.351000 2.10e-08
Regulation of HSF1-mediated heat shock response 76 1.25e-07 -0.351000 1.61e-06
Defective CFTR causes cystic fibrosis 59 3.27e-06 -0.350000 2.50e-05
Downregulation of SMAD2/3:SMAD4 transcriptional activity 26 2.02e-03 -0.350000 6.00e-03
TBC/RABGAPs 42 8.86e-05 -0.349000 3.91e-04
Signaling by ALK fusions and activated point mutants 51 1.59e-05 -0.349000 9.26e-05
Signaling by ALK in cancer 51 1.59e-05 -0.349000 9.26e-05
Cytosolic iron-sulfur cluster assembly 10 5.60e-02 -0.349000 1.03e-01
HIV elongation arrest and recovery 25 2.53e-03 -0.349000 7.18e-03
Pausing and recovery of HIV elongation 25 2.53e-03 -0.349000 7.18e-03
Interaction With Cumulus Cells And The Zona Pellucida 11 4.52e-02 0.349000 8.63e-02
Vif-mediated degradation of APOBEC3G 50 2.01e-05 -0.348000 1.11e-04
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 40 1.37e-04 -0.348000 5.69e-04
APC/C:Cdc20 mediated degradation of Cyclin B 22 4.75e-03 -0.348000 1.26e-02
Degradation of GLI1 by the proteasome 58 4.63e-06 -0.348000 3.26e-05
TP53 Regulates Transcription of DNA Repair Genes 52 1.47e-05 -0.347000 8.71e-05
Influenza Viral RNA Transcription and Replication 128 1.25e-11 -0.347000 3.74e-10
Constitutive Signaling by AKT1 E17K in Cancer 24 3.44e-03 -0.345000 9.39e-03
Influenza Infection 147 5.39e-13 -0.345000 2.16e-11
Vpu mediated degradation of CD4 50 2.50e-05 -0.344000 1.35e-04
Nuclear Envelope Breakdown 47 4.37e-05 -0.344000 2.13e-04
Nuclear Events (kinase and transcription factor activation) 60 4.31e-06 -0.343000 3.05e-05
p53-Dependent G1 DNA Damage Response 64 2.14e-06 -0.342000 1.73e-05
p53-Dependent G1/S DNA damage checkpoint 64 2.14e-06 -0.342000 1.73e-05
cGMP effects 15 2.16e-02 0.342000 4.75e-02
MAP kinase activation 56 9.48e-06 -0.342000 5.98e-05
Complement cascade 55 1.16e-05 0.342000 7.12e-05
RNA Polymerase III Transcription Initiation 36 3.92e-04 -0.341000 1.46e-03
Calnexin/calreticulin cycle 25 3.18e-03 -0.341000 8.76e-03
mRNA decay by 3’ to 5’ exoribonuclease 15 2.23e-02 -0.341000 4.83e-02
Diseases associated with glycosylation precursor biosynthesis 15 2.27e-02 -0.340000 4.91e-02
Regulation of expression of SLITs and ROBOs 158 1.82e-13 -0.339000 7.69e-12
Regulation of RUNX3 expression and activity 53 1.94e-05 -0.339000 1.08e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 61 4.74e-06 -0.339000 3.32e-05
Chromosome Maintenance 78 2.36e-07 -0.338000 2.85e-06
Intraflagellar transport 32 9.31e-04 -0.338000 3.13e-03
GLI3 is processed to GLI3R by the proteasome 58 8.93e-06 -0.337000 5.68e-05
Metabolism of polyamines 54 1.82e-05 -0.337000 1.03e-04
Resolution of Abasic Sites (AP sites) 37 3.92e-04 -0.337000 1.46e-03
FLT3 signaling in disease 28 2.08e-03 -0.336000 6.12e-03
RHO GTPases Activate Formins 111 9.43e-10 -0.336000 1.94e-08
RNA polymerase II transcribes snRNA genes 71 9.75e-07 -0.336000 8.99e-06
Phase 2 - plateau phase 14 2.95e-02 0.336000 6.06e-02
HCMV Late Events 50 4.02e-05 -0.336000 1.98e-04
MicroRNA (miRNA) biogenesis 21 8.14e-03 -0.333000 2.03e-02
Assembly of the pre-replicative complex 74 7.13e-07 -0.333000 7.04e-06
BBSome-mediated cargo-targeting to cilium 22 6.85e-03 -0.333000 1.73e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 28 2.29e-03 -0.333000 6.69e-03
Regulation of ornithine decarboxylase (ODC) 49 5.61e-05 -0.333000 2.61e-04
Signaling by FGFR2 71 1.26e-06 -0.332000 1.10e-05
RNA Polymerase III Abortive And Retractive Initiation 41 2.42e-04 -0.331000 9.57e-04
RNA Polymerase III Transcription 41 2.42e-04 -0.331000 9.57e-04
MET receptor recycling 10 7.01e-02 -0.331000 1.26e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 55 2.21e-05 -0.331000 1.21e-04
MyD88 cascade initiated on plasma membrane 77 5.38e-07 -0.330000 5.72e-06
Toll Like Receptor 10 (TLR10) Cascade 77 5.38e-07 -0.330000 5.72e-06
Toll Like Receptor 5 (TLR5) Cascade 77 5.38e-07 -0.330000 5.72e-06
Activation of NF-kappaB in B cells 64 4.88e-06 -0.330000 3.40e-05
M Phase 316 5.81e-24 -0.330000 6.31e-22
DNA Damage Bypass 45 1.28e-04 -0.330000 5.37e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 3.24e-05 -0.330000 1.67e-04
The citric acid (TCA) cycle and respiratory electron transport 132 6.11e-11 -0.330000 1.69e-09
UCH proteinases 81 2.93e-07 -0.329000 3.37e-06
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 5.58e-05 -0.329000 2.61e-04
p53-Independent DNA Damage Response 50 5.58e-05 -0.329000 2.61e-04
p53-Independent G1/S DNA damage checkpoint 50 5.58e-05 -0.329000 2.61e-04
Mitotic Metaphase and Anaphase 212 1.48e-16 -0.329000 8.64e-15
Negative regulation of FGFR3 signaling 28 2.62e-03 -0.329000 7.40e-03
Eukaryotic Translation Elongation 88 9.91e-08 -0.329000 1.31e-06
Telomere C-strand (Lagging Strand) Synthesis 30 1.85e-03 -0.328000 5.58e-03
Regulation of PTEN gene transcription 54 3.03e-05 -0.328000 1.58e-04
SUMOylation of DNA damage response and repair proteins 70 2.12e-06 -0.328000 1.73e-05
Frs2-mediated activation 12 4.99e-02 -0.327000 9.36e-02
Translation initiation complex formation 54 3.26e-05 -0.327000 1.67e-04
Removal of the Flap Intermediate 13 4.14e-02 -0.327000 7.99e-02
Glucocorticoid biosynthesis 10 7.36e-02 0.327000 1.30e-01
Calcitonin-like ligand receptors 10 7.37e-02 0.327000 1.30e-01
Mitotic Anaphase 211 2.85e-16 -0.327000 1.60e-14
SARS-CoV-2-host interactions 171 1.80e-13 -0.326000 7.69e-12
RAB geranylgeranylation 54 3.37e-05 -0.326000 1.71e-04
Signaling by NOTCH4 79 5.52e-07 -0.326000 5.83e-06
InlB-mediated entry of Listeria monocytogenes into host cell 14 3.48e-02 -0.326000 6.90e-02
APC-Cdc20 mediated degradation of Nek2A 24 5.78e-03 -0.325000 1.48e-02
EPHB-mediated forward signaling 33 1.21e-03 -0.325000 3.94e-03
AURKA Activation by TPX2 62 9.66e-06 -0.325000 6.02e-05
G2/M Transition 165 5.96e-13 -0.325000 2.32e-11
Regulation of PLK1 Activity at G2/M Transition 75 1.16e-06 -0.325000 1.02e-05
APC/C:Cdc20 mediated degradation of Securin 64 7.49e-06 -0.324000 4.85e-05
Eukaryotic Translation Termination 87 1.85e-07 -0.323000 2.27e-06
Peptide chain elongation 84 3.07e-07 -0.323000 3.51e-06
Toll Like Receptor 9 (TLR9) Cascade 85 2.65e-07 -0.323000 3.15e-06
rRNA processing in the nucleus and cytosol 176 1.50e-13 -0.323000 6.70e-12
G1/S DNA Damage Checkpoints 66 5.78e-06 -0.323000 3.85e-05
RHO GTPases activate CIT 19 1.49e-02 -0.323000 3.42e-02
Cap-dependent Translation Initiation 112 3.95e-09 -0.322000 6.66e-08
Eukaryotic Translation Initiation 112 3.95e-09 -0.322000 6.66e-08
Voltage gated Potassium channels 42 3.07e-04 0.322000 1.19e-03
Degradation of DVL 55 3.64e-05 -0.322000 1.84e-04
VLDLR internalisation and degradation 16 2.58e-02 -0.322000 5.43e-02
Platelet sensitization by LDL 17 2.16e-02 -0.322000 4.75e-02
Late Phase of HIV Life Cycle 118 1.73e-09 -0.321000 3.20e-08
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 1.68e-07 -0.321000 2.11e-06
Major pathway of rRNA processing in the nucleolus and cytosol 169 6.44e-13 -0.320000 2.45e-11
Golgi-to-ER retrograde transport 114 3.37e-09 -0.320000 5.89e-08
Negative regulation of FGFR4 signaling 30 2.41e-03 -0.320000 6.98e-03
rRNA processing 180 1.35e-13 -0.320000 6.21e-12
SUMOylation of chromatin organization proteins 53 5.72e-05 -0.319000 2.66e-04
Formation of HIV-1 elongation complex containing HIV-1 Tat 34 1.28e-03 -0.319000 4.10e-03
HIV Transcription Elongation 34 1.28e-03 -0.319000 4.10e-03
Tat-mediated elongation of the HIV-1 transcript 34 1.28e-03 -0.319000 4.10e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 3.92e-06 -0.319000 2.85e-05
NOD1/2 Signaling Pathway 27 4.21e-03 -0.318000 1.13e-02
MyD88 dependent cascade initiated on endosome 82 6.30e-07 -0.318000 6.30e-06
Toll Like Receptor 7/8 (TLR7/8) Cascade 82 6.30e-07 -0.318000 6.30e-06
Transcription of the HIV genome 58 2.82e-05 -0.318000 1.48e-04
HCMV Infection 75 1.96e-06 -0.318000 1.62e-05
Regulation of TP53 Activity through Phosphorylation 86 3.52e-07 -0.318000 3.97e-06
Cell Cycle, Mitotic 448 9.97e-31 -0.317000 1.68e-28
Apoptotic factor-mediated response 17 2.35e-02 -0.317000 5.03e-02
Signaling by ALK 26 5.15e-03 -0.317000 1.34e-02
Intra-Golgi traffic 41 4.50e-04 -0.317000 1.65e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 72 3.37e-06 -0.317000 2.53e-05
Telomere Extension By Telomerase 21 1.20e-02 -0.317000 2.85e-02
Recognition of DNA damage by PCNA-containing replication complex 29 3.16e-03 -0.317000 8.73e-03
PRC2 methylates histones and DNA 13 4.85e-02 -0.316000 9.11e-02
Mitotic G2-G2/M phases 167 1.86e-12 -0.316000 6.43e-11
Postmitotic nuclear pore complex (NPC) reformation 25 6.31e-03 -0.316000 1.61e-02
Viral mRNA Translation 84 5.78e-07 -0.315000 6.06e-06
Activation of Matrix Metalloproteinases 30 2.79e-03 0.315000 7.85e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 7.49e-03 -0.315000 1.88e-02
Synthesis of PIPs at the late endosome membrane 10 8.43e-02 -0.315000 1.45e-01
NIK–>noncanonical NF-kB signaling 57 3.83e-05 -0.315000 1.91e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 69 6.21e-06 -0.315000 4.12e-05
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 3.37e-06 -0.314000 2.53e-05
Centrosome maturation 68 7.48e-06 -0.314000 4.85e-05
Recruitment of mitotic centrosome proteins and complexes 68 7.48e-06 -0.314000 4.85e-05
Formation of the ternary complex, and subsequently, the 43S complex 47 1.95e-04 -0.314000 7.81e-04
Regulation of Apoptosis 51 1.06e-04 -0.314000 4.61e-04
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 81 1.04e-06 -0.314000 9.49e-06
Ribosomal scanning and start codon recognition 54 6.65e-05 -0.314000 3.05e-04
Carnitine metabolism 11 7.16e-02 0.314000 1.28e-01
TNFR1-induced NFkappaB signaling pathway 20 1.54e-02 -0.313000 3.51e-02
HIV Infection 208 7.50e-15 -0.313000 3.80e-13
Chylomicron remodeling 10 8.72e-02 0.312000 1.49e-01
Nuclear events mediated by NFE2L2 76 2.52e-06 -0.312000 1.96e-05
COPII-mediated vesicle transport 63 1.84e-05 -0.312000 1.03e-04
Apoptotic cleavage of cell adhesion proteins 11 7.32e-02 0.312000 1.30e-01
Assembly of active LPL and LIPC lipase complexes 17 2.60e-02 0.312000 5.46e-02
DNA Replication Pre-Initiation 88 4.25e-07 -0.312000 4.72e-06
Metabolism of folate and pterines 16 3.09e-02 -0.312000 6.31e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 13 5.18e-02 -0.311000 9.66e-02
Cell Cycle 561 1.70e-36 -0.311000 4.31e-34
Zinc transporters 17 2.64e-02 -0.311000 5.53e-02
Anchoring of the basal body to the plasma membrane 83 9.83e-07 -0.311000 9.00e-06
XBP1(S) activates chaperone genes 47 2.28e-04 -0.311000 9.06e-04
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.42e-02 -0.311000 8.47e-02
Acyl chain remodelling of PG 17 2.66e-02 0.311000 5.57e-02
Heme degradation 16 3.15e-02 0.310000 6.40e-02
Surfactant metabolism 28 4.47e-03 0.310000 1.19e-02
SCF-beta-TrCP mediated degradation of Emi1 53 9.27e-05 -0.310000 4.08e-04
Formation of HIV elongation complex in the absence of HIV Tat 36 1.28e-03 -0.310000 4.10e-03
FCERI mediated NF-kB activation 72 5.40e-06 -0.310000 3.62e-05
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 70 7.33e-06 -0.310000 4.80e-05
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.47e-02 -0.310000 8.54e-02
Telomere Maintenance 59 3.85e-05 -0.310000 1.91e-04
Cellular response to heat stress 93 2.42e-07 -0.310000 2.90e-06
Selenocysteine synthesis 87 6.09e-07 -0.309000 6.21e-06
Degradation of GLI2 by the proteasome 58 4.78e-05 -0.309000 2.30e-04
HIV Life Cycle 131 1.07e-09 -0.308000 2.10e-08
Pyruvate metabolism and Citric Acid (TCA) cycle 50 1.61e-04 -0.308000 6.55e-04
Chaperone Mediated Autophagy 19 1.99e-02 -0.308000 4.42e-02
Formation of apoptosome 10 9.12e-02 -0.308000 1.55e-01
Regulation of the apoptosome activity 10 9.12e-02 -0.308000 1.55e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.88e-03 -0.308000 5.64e-03
G1/S Transition 119 6.46e-09 -0.308000 1.06e-07
Regulation of signaling by CBL 18 2.38e-02 -0.308000 5.07e-02
Recruitment of NuMA to mitotic centrosomes 67 1.33e-05 -0.308000 7.98e-05
Cyclin E associated events during G1/S transition 81 1.85e-06 -0.306000 1.55e-05
PCNA-Dependent Long Patch Base Excision Repair 21 1.51e-02 -0.306000 3.45e-02
Long-term potentiation 22 1.29e-02 0.306000 3.00e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 94 2.88e-07 -0.306000 3.35e-06
RHO GTPases Activate WASPs and WAVEs 33 2.39e-03 -0.305000 6.96e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 3.83e-03 -0.305000 1.04e-02
Protein ubiquitination 59 5.09e-05 -0.305000 2.43e-04
L13a-mediated translational silencing of Ceruloplasmin expression 104 8.07e-08 -0.304000 1.09e-06
rRNA modification in the nucleus and cytosol 51 1.71e-04 -0.304000 6.91e-04
Signaling by FGFR2 IIIa TM 19 2.17e-02 -0.304000 4.76e-02
Downstream signaling events of B Cell Receptor (BCR) 78 3.53e-06 -0.304000 2.62e-05
Toll Like Receptor 3 (TLR3) Cascade 86 1.16e-06 -0.303000 1.02e-05
MAPK3 (ERK1) activation 10 9.70e-02 -0.303000 1.62e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 105 8.24e-08 -0.303000 1.10e-06
Formation of a pool of free 40S subunits 95 3.51e-07 -0.302000 3.97e-06
DNA Repair 262 3.76e-17 -0.302000 2.29e-15
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 5.69e-03 -0.302000 1.46e-02
Mitotic G1 phase and G1/S transition 137 1.05e-09 -0.302000 2.10e-08
ER-Phagosome pathway 87 1.16e-06 -0.302000 1.02e-05
Cyclin A:Cdk2-associated events at S phase entry 83 2.05e-06 -0.301000 1.68e-05
Intra-Golgi and retrograde Golgi-to-ER traffic 177 5.40e-12 -0.300000 1.75e-10
Negative regulation of NMDA receptor-mediated neuronal transmission 20 2.01e-02 0.300000 4.45e-02
Phase 4 - resting membrane potential 19 2.37e-02 0.300000 5.07e-02
Loss of Nlp from mitotic centrosomes 59 6.84e-05 -0.300000 3.11e-04
Loss of proteins required for interphase microtubule organization from the centrosome 59 6.84e-05 -0.300000 3.11e-04
Presynaptic nicotinic acetylcholine receptors 12 7.28e-02 0.299000 1.30e-01
Gap junction degradation 10 1.01e-01 -0.299000 1.68e-01
Fertilization 22 1.52e-02 0.299000 3.47e-02
Amine ligand-binding receptors 41 9.25e-04 0.299000 3.12e-03
MyD88-independent TLR4 cascade 90 9.58e-07 -0.299000 8.88e-06
TRIF(TICAM1)-mediated TLR4 signaling 90 9.58e-07 -0.299000 8.88e-06
RUNX1 regulates transcription of genes involved in differentiation of HSCs 67 2.36e-05 -0.299000 1.29e-04
APC/C-mediated degradation of cell cycle proteins 84 2.45e-06 -0.297000 1.92e-05
Regulation of mitotic cell cycle 84 2.45e-06 -0.297000 1.92e-05
Blood group systems biosynthesis 22 1.59e-02 0.297000 3.61e-02
Polo-like kinase mediated events 16 3.96e-02 -0.297000 7.72e-02
COPI-mediated anterograde transport 82 3.33e-06 -0.297000 2.53e-05
Purine salvage 12 7.58e-02 -0.296000 1.33e-01
Downregulation of ERBB2:ERBB3 signaling 13 6.46e-02 -0.296000 1.17e-01
HIV Transcription Initiation 43 7.92e-04 -0.296000 2.70e-03
RNA Polymerase II HIV Promoter Escape 43 7.92e-04 -0.296000 2.70e-03
RNA Polymerase II Promoter Escape 43 7.92e-04 -0.296000 2.70e-03
RNA Polymerase II Transcription Initiation 43 7.92e-04 -0.296000 2.70e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 7.92e-04 -0.296000 2.70e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 7.92e-04 -0.296000 2.70e-03
Prefoldin mediated transfer of substrate to CCT/TriC 25 1.05e-02 -0.296000 2.51e-02
Protein methylation 11 8.95e-02 -0.296000 1.52e-01
Formation of the Early Elongation Complex 28 6.89e-03 -0.295000 1.73e-02
Formation of the HIV-1 Early Elongation Complex 28 6.89e-03 -0.295000 1.73e-02
Extension of Telomeres 45 6.21e-04 -0.295000 2.21e-03
Cytosolic sensors of pathogen-associated DNA 60 7.89e-05 -0.295000 3.53e-04
AKT phosphorylates targets in the cytosol 14 5.65e-02 -0.294000 1.04e-01
G0 and Early G1 27 8.11e-03 -0.294000 2.03e-02
Negative regulation of MET activity 20 2.28e-02 -0.294000 4.91e-02
Synthesis of PE 11 9.18e-02 -0.294000 1.55e-01
Orc1 removal from chromatin 63 5.75e-05 -0.293000 2.66e-04
Signaling by ROBO receptors 201 8.23e-13 -0.293000 2.98e-11
Nuclear events stimulated by ALK signaling in cancer 18 3.20e-02 -0.292000 6.47e-02
mRNA Capping 28 7.56e-03 -0.292000 1.90e-02
Class I peroxisomal membrane protein import 18 3.27e-02 -0.291000 6.59e-02
CD28 dependent Vav1 pathway 11 9.52e-02 -0.291000 1.60e-01
Phase 0 - rapid depolarisation 31 5.14e-03 0.290000 1.34e-02
NGF-stimulated transcription 39 1.70e-03 -0.290000 5.18e-03
CDK-mediated phosphorylation and removal of Cdc6 69 3.09e-05 -0.290000 1.60e-04
Purine ribonucleoside monophosphate biosynthesis 11 9.58e-02 -0.290000 1.61e-01
Phosphorylation of the APC/C 18 3.33e-02 -0.290000 6.65e-02
Mismatch Repair 15 5.24e-02 -0.289000 9.72e-02
DNA Replication 116 7.66e-08 -0.289000 1.06e-06
Regulation of IFNG signaling 14 6.14e-02 -0.289000 1.12e-01
Response of Mtb to phagocytosis 22 1.92e-02 -0.288000 4.28e-02
Nuclear Envelope (NE) Reassembly 68 4.05e-05 -0.288000 1.99e-04
Chromatin modifying enzymes 167 1.47e-10 -0.287000 3.61e-09
Chromatin organization 167 1.47e-10 -0.287000 3.61e-09
Rab regulation of trafficking 103 4.69e-07 -0.287000 5.13e-06
SARS-CoV-2 activates/modulates innate and adaptive immune responses 99 8.47e-07 -0.286000 8.10e-06
Signaling by the B Cell Receptor (BCR) 105 4.53e-07 -0.285000 4.99e-06
Visual phototransduction 90 2.98e-06 0.285000 2.30e-05
Transcriptional Regulation by TP53 321 2.41e-18 -0.283000 1.75e-16
Signaling by FGFR3 39 2.19e-03 -0.283000 6.41e-03
Glycogen metabolism 24 1.63e-02 -0.283000 3.69e-02
Regulation of TP53 Activity 149 2.44e-09 -0.283000 4.35e-08
Negative regulation of FGFR1 signaling 32 5.59e-03 -0.283000 1.44e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.68e-02 -0.283000 1.21e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.68e-02 -0.283000 1.21e-01
Regulation of APC/C activators between G1/S and early anaphase 77 1.80e-05 -0.283000 1.02e-04
Regulation of Complement cascade 44 1.23e-03 0.282000 3.98e-03
Global Genome Nucleotide Excision Repair (GG-NER) 81 1.18e-05 -0.281000 7.22e-05
MET activates RAP1 and RAC1 11 1.06e-01 -0.281000 1.74e-01
Signaling by cytosolic FGFR1 fusion mutants 16 5.19e-02 -0.281000 9.68e-02
RNA Polymerase III Chain Elongation 18 3.95e-02 -0.280000 7.71e-02
SARS-CoV-2 Infection 249 2.93e-14 -0.280000 1.39e-12
Branched-chain amino acid catabolism 20 3.09e-02 -0.279000 6.31e-02
PINK1-PRKN Mediated Mitophagy 20 3.10e-02 -0.279000 6.32e-02
RHO GTPases activate KTN1 11 1.10e-01 -0.278000 1.80e-01
IRE1alpha activates chaperones 49 7.49e-04 -0.278000 2.60e-03
Cytosolic sulfonation of small molecules 22 2.39e-02 0.278000 5.08e-02
Ketone body metabolism 10 1.28e-01 0.278000 2.00e-01
NoRC negatively regulates rRNA expression 43 1.61e-03 -0.278000 4.92e-03
Switching of origins to a post-replicative state 82 1.34e-05 -0.278000 8.01e-05
Gene Silencing by RNA 73 4.01e-05 -0.278000 1.98e-04
Cellular response to hypoxia 70 5.82e-05 -0.278000 2.69e-04
Cholesterol biosynthesis 22 2.43e-02 -0.277000 5.17e-02
Formation of tubulin folding intermediates by CCT/TriC 24 1.87e-02 -0.277000 4.19e-02
Translesion synthesis by POLK 17 4.80e-02 -0.277000 9.05e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 21 2.80e-02 -0.277000 5.78e-02
Synthesis of DNA 109 5.93e-07 -0.277000 6.13e-06
TNFR1-induced proapoptotic signaling 13 8.41e-02 -0.277000 1.45e-01
S Phase 148 6.32e-09 -0.277000 1.04e-07
Aflatoxin activation and detoxification 20 3.26e-02 0.276000 6.57e-02
TP53 Regulates Transcription of Death Receptors and Ligands 12 9.78e-02 -0.276000 1.63e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 34 5.43e-03 -0.275000 1.41e-02
RNA Polymerase III Transcription Termination 23 2.23e-02 -0.275000 4.83e-02
Glucose metabolism 85 1.19e-05 -0.275000 7.23e-05
Negative regulation of FGFR2 signaling 33 6.43e-03 -0.274000 1.64e-02
Attenuation phase 25 1.77e-02 -0.274000 4.00e-02
Defective pyroptosis 11 1.16e-01 -0.274000 1.86e-01
Activation of ATR in response to replication stress 30 9.44e-03 -0.274000 2.30e-02
SARS-CoV Infections 323 3.16e-17 -0.273000 2.00e-15
Caspase activation via Death Receptors in the presence of ligand 16 5.87e-02 -0.273000 1.07e-01
Transcriptional activation of mitochondrial biogenesis 48 1.08e-03 -0.273000 3.59e-03
RHO GTPases Activate ROCKs 19 3.97e-02 -0.273000 7.72e-02
Suppression of phagosomal maturation 13 8.90e-02 -0.272000 1.52e-01
Killing mechanisms 11 1.18e-01 -0.272000 1.90e-01
WNT5:FZD7-mediated leishmania damping 11 1.18e-01 -0.272000 1.90e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 4.09e-02 0.271000 7.92e-02
Kinesins 42 2.40e-03 -0.271000 6.96e-03
Signaling by NOTCH2 31 9.16e-03 -0.270000 2.25e-02
Oncogene Induced Senescence 32 8.17e-03 -0.270000 2.03e-02
Glycolysis 66 1.49e-04 -0.270000 6.13e-04
Degradation of AXIN 53 6.84e-04 -0.270000 2.39e-03
Unblocking of NMDA receptors, glutamate binding and activation 19 4.19e-02 0.270000 8.07e-02
Negative epigenetic regulation of rRNA expression 45 1.76e-03 -0.269000 5.33e-03
Signaling by FGFR 84 2.02e-05 -0.269000 1.12e-04
Purine catabolism 15 7.15e-02 -0.269000 1.28e-01
Signaling by FGFR4 40 3.27e-03 -0.269000 8.99e-03
RMTs methylate histone arginines 29 1.23e-02 -0.269000 2.90e-02
The phototransduction cascade 30 1.12e-02 0.268000 2.66e-02
Cilium Assembly 159 5.94e-09 -0.267000 9.91e-08
Dectin-1 mediated noncanonical NF-kB signaling 60 3.42e-04 -0.267000 1.31e-03
Regulation of PTEN mRNA translation 21 3.45e-02 0.267000 6.85e-02
Drug ADME 94 8.02e-06 0.266000 5.12e-05
Interleukin-17 signaling 64 2.33e-04 -0.266000 9.24e-04
CLEC7A (Dectin-1) induces NFAT activation 11 1.27e-01 -0.266000 1.99e-01
Defective C1GALT1C1 causes TNPS 15 7.47e-02 0.266000 1.32e-01
ER to Golgi Anterograde Transport 130 1.73e-07 -0.265000 2.13e-06
Bicarbonate transporters 10 1.46e-01 0.265000 2.25e-01
Cellular response to starvation 138 7.51e-08 -0.265000 1.05e-06
Transcriptional regulation by RUNX3 93 1.04e-05 -0.264000 6.44e-05
Mitochondrial iron-sulfur cluster biogenesis 12 1.14e-01 -0.264000 1.84e-01
Defective GALNT12 causes CRCS1 15 7.70e-02 0.264000 1.35e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 5.50e-03 -0.264000 1.42e-02
The role of Nef in HIV-1 replication and disease pathogenesis 27 1.78e-02 -0.263000 4.02e-02
Regulation of pyruvate dehydrogenase (PDH) complex 14 8.85e-02 -0.263000 1.51e-01
SARS-CoV-1 Infection 49 1.47e-03 -0.263000 4.58e-03
Transport of organic anions 10 1.50e-01 0.263000 2.29e-01
LDL clearance 19 4.76e-02 -0.262000 9.03e-02
Lagging Strand Synthesis 19 4.79e-02 -0.262000 9.05e-02
Regulation of RUNX2 expression and activity 71 1.36e-04 -0.262000 5.69e-04
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 47 1.91e-03 -0.262000 5.71e-03
MAPK6/MAPK4 signaling 85 3.09e-05 -0.261000 1.60e-04
Nucleotide Excision Repair 106 3.34e-06 -0.261000 2.53e-05
Degradation of beta-catenin by the destruction complex 81 4.81e-05 -0.261000 2.30e-04
Transcriptional regulation of granulopoiesis 30 1.34e-02 -0.261000 3.11e-02
Mitochondrial protein import 48 1.77e-03 -0.261000 5.36e-03
Interleukin-1 signaling 95 1.12e-05 -0.261000 6.88e-05
Rap1 signalling 16 7.10e-02 -0.261000 1.27e-01
RAF-independent MAPK1/3 activation 22 3.45e-02 -0.260000 6.85e-02
activated TAK1 mediates p38 MAPK activation 14 9.18e-02 -0.260000 1.55e-01
Chaperonin-mediated protein folding 88 2.47e-05 -0.260000 1.35e-04
TP53 Regulates Transcription of Cell Cycle Genes 47 2.04e-03 -0.260000 6.03e-03
DNA strand elongation 30 1.38e-02 -0.260000 3.20e-02
Unfolded Protein Response (UPR) 86 3.10e-05 -0.260000 1.60e-04
Interferon alpha/beta signaling 63 3.61e-04 -0.260000 1.38e-03
Negative regulation of MAPK pathway 41 4.05e-03 -0.259000 1.09e-02
Erythrocytes take up carbon dioxide and release oxygen 12 1.20e-01 0.259000 1.92e-01
O2/CO2 exchange in erythrocytes 12 1.20e-01 0.259000 1.92e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.21e-01 -0.258000 1.93e-01
Pentose phosphate pathway 11 1.38e-01 -0.258000 2.14e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 1.38e-01 -0.258000 2.15e-01
Dual Incision in GG-NER 39 5.35e-03 -0.258000 1.39e-02
Interleukin-2 signaling 10 1.59e-01 -0.257000 2.40e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 1.40e-01 -0.257000 2.16e-01
Protein folding 94 1.66e-05 -0.257000 9.57e-05
ABC transporter disorders 75 1.22e-04 -0.257000 5.18e-04
Activated NTRK2 signals through FRS2 and FRS3 11 1.41e-01 -0.256000 2.17e-01
CLEC7A (Dectin-1) signaling 94 1.75e-05 -0.256000 1.01e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF) 52 1.40e-03 -0.256000 4.42e-03
PECAM1 interactions 12 1.25e-01 -0.256000 1.98e-01
Acyl chain remodelling of PS 20 4.77e-02 0.256000 9.04e-02
Unwinding of DNA 11 1.42e-01 -0.255000 2.19e-01
DNA Damage/Telomere Stress Induced Senescence 28 1.95e-02 -0.255000 4.34e-02
Cytochrome c-mediated apoptotic response 12 1.27e-01 -0.255000 1.99e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 1.34e-03 -0.255000 4.23e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 1.34e-03 -0.255000 4.23e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 1.34e-03 -0.255000 4.23e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 1.34e-03 -0.255000 4.23e-03
Signaling by NOTCH1 in Cancer 53 1.34e-03 -0.255000 4.23e-03
NOTCH1 Intracellular Domain Regulates Transcription 44 3.55e-03 -0.254000 9.68e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.13e-01 -0.254000 1.84e-01
Diseases associated with O-glycosylation of proteins 60 6.76e-04 0.254000 2.38e-03
Selenoamino acid metabolism 103 9.64e-06 -0.252000 6.02e-05
Pyruvate metabolism 27 2.35e-02 -0.252000 5.03e-02
FCGR3A-mediated phagocytosis 56 1.13e-03 -0.252000 3.71e-03
Leishmania phagocytosis 56 1.13e-03 -0.252000 3.71e-03
Parasite infection 56 1.13e-03 -0.252000 3.71e-03
Activation of gene expression by SREBF (SREBP) 40 5.97e-03 -0.251000 1.53e-02
TRAF6 mediated NF-kB activation 24 3.32e-02 -0.251000 6.65e-02
Potential therapeutics for SARS 83 7.68e-05 -0.251000 3.44e-04
Methylation 14 1.04e-01 -0.251000 1.72e-01
STAT5 activation downstream of FLT3 ITD mutants 10 1.70e-01 -0.251000 2.53e-01
Regulation of RAS by GAPs 66 4.37e-04 -0.250000 1.61e-03
RNA Pol II CTD phosphorylation and interaction with CE 26 2.75e-02 -0.250000 5.71e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 2.75e-02 -0.250000 5.71e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 28 2.25e-02 -0.249000 4.86e-02
Translation of Structural Proteins 29 2.02e-02 -0.249000 4.47e-02
Oxidative Stress Induced Senescence 62 6.96e-04 -0.249000 2.42e-03
Organelle biogenesis and maintenance 225 1.25e-10 -0.249000 3.18e-09
Passive transport by Aquaporins 13 1.20e-01 0.249000 1.92e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 9.52e-02 -0.249000 1.60e-01
HSF1 activation 27 2.52e-02 -0.249000 5.33e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 6.78e-02 -0.249000 1.22e-01
SUMO E3 ligases SUMOylate target proteins 157 8.00e-08 -0.248000 1.09e-06
RHOV GTPase cycle 34 1.23e-02 -0.248000 2.89e-02
Regulated Necrosis 52 1.96e-03 -0.248000 5.84e-03
Activation of HOX genes during differentiation 57 1.19e-03 -0.248000 3.90e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis 57 1.19e-03 -0.248000 3.90e-03
Adherens junctions interactions 26 2.91e-02 0.247000 5.99e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 9.78e-02 0.247000 1.63e-01
Glycogen breakdown (glycogenolysis) 12 1.41e-01 -0.246000 2.17e-01
Retrograde transport at the Trans-Golgi-Network 45 4.40e-03 -0.245000 1.17e-02
KEAP1-NFE2L2 pathway 102 1.86e-05 -0.245000 1.04e-04
SUMOylation of transcription factors 20 5.77e-02 -0.245000 1.06e-01
Prolonged ERK activation events 14 1.12e-01 -0.245000 1.83e-01
Toll-like Receptor Cascades 138 6.73e-07 -0.245000 6.69e-06
Processive synthesis on the lagging strand 14 1.14e-01 -0.244000 1.84e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 26 3.14e-02 -0.244000 6.38e-02
Inactivation, recovery and regulation of the phototransduction cascade 29 2.37e-02 0.243000 5.07e-02
COPI-independent Golgi-to-ER retrograde traffic 34 1.44e-02 -0.243000 3.33e-02
Meiotic recombination 26 3.28e-02 -0.242000 6.59e-02
RHOBTB GTPase Cycle 33 1.62e-02 -0.242000 3.68e-02
Transcriptional Regulation by E2F6 32 1.79e-02 -0.242000 4.04e-02
Toll Like Receptor 4 (TLR4) Cascade 122 3.99e-06 -0.242000 2.88e-05
Translesion synthesis by REV1 16 9.47e-02 -0.241000 1.60e-01
Nucleotide salvage 21 5.57e-02 -0.241000 1.03e-01
Protein localization 137 1.16e-06 -0.241000 1.02e-05
ERBB2 Activates PTK6 Signaling 13 1.33e-01 0.240000 2.07e-01
RNA Polymerase I Promoter Escape 28 2.77e-02 -0.240000 5.73e-02
Caspase activation via extrinsic apoptotic signalling pathway 25 3.75e-02 -0.240000 7.36e-02
Senescence-Associated Secretory Phenotype (SASP) 49 3.65e-03 -0.240000 9.92e-03
SUMOylation 163 1.24e-07 -0.240000 1.60e-06
FGFR1 mutant receptor activation 29 2.53e-02 -0.240000 5.33e-02
RHOBTB2 GTPase cycle 21 5.70e-02 -0.240000 1.05e-01
Signaling by TGF-beta Receptor Complex 86 1.23e-04 -0.239000 5.20e-04
Estrogen-dependent gene expression 87 1.16e-04 -0.239000 4.94e-04
FCERI mediated MAPK activation 29 2.58e-02 -0.239000 5.43e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 12 1.52e-01 -0.239000 2.31e-01
RAB GEFs exchange GTP for GDP on RABs 72 4.58e-04 -0.239000 1.67e-03
Signaling by FGFR1 49 3.92e-03 -0.238000 1.06e-02
Lewis blood group biosynthesis 18 8.07e-02 0.238000 1.40e-01
Acyl chain remodelling of PI 15 1.11e-01 0.238000 1.81e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 61 1.32e-03 -0.238000 4.22e-03
Asymmetric localization of PCP proteins 62 1.21e-03 -0.238000 3.94e-03
CD28 co-stimulation 32 2.01e-02 -0.237000 4.45e-02
Asparagine N-linked glycosylation 273 1.55e-11 -0.237000 4.53e-10
Selective autophagy 58 1.81e-03 -0.237000 5.46e-03
Fc epsilon receptor (FCERI) signaling 124 5.24e-06 -0.237000 3.60e-05
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 4.76e-04 -0.236000 1.73e-03
Cytochrome P450 - arranged by substrate type 64 1.07e-03 0.236000 3.57e-03
Adenylate cyclase activating pathway 10 1.96e-01 0.236000 2.85e-01
Synthesis of PIPs at the early endosome membrane 15 1.14e-01 -0.236000 1.84e-01
Early Phase of HIV Life Cycle 14 1.27e-01 -0.236000 1.99e-01
RNA Polymerase I Transcription 47 5.19e-03 -0.236000 1.35e-02
Cyclin D associated events in G1 46 5.77e-03 -0.235000 1.48e-02
G1 Phase 46 5.77e-03 -0.235000 1.48e-02
Disorders of Developmental Biology 11 1.77e-01 -0.235000 2.60e-01
Disorders of Nervous System Development 11 1.77e-01 -0.235000 2.60e-01
Loss of function of MECP2 in Rett syndrome 11 1.77e-01 -0.235000 2.60e-01
Pervasive developmental disorders 11 1.77e-01 -0.235000 2.60e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 16 1.04e-01 -0.235000 1.71e-01
Budding and maturation of HIV virion 25 4.27e-02 -0.234000 8.20e-02
Signaling by NTRK1 (TRKA) 114 1.57e-05 -0.234000 9.23e-05
Constitutive Signaling by Overexpressed ERBB2 10 2.00e-01 -0.234000 2.90e-01
Growth hormone receptor signaling 24 4.76e-02 -0.234000 9.03e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 1.06e-01 -0.233000 1.74e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 1.10e-04 -0.233000 4.73e-04
Toll Like Receptor 2 (TLR2) Cascade 92 1.10e-04 -0.233000 4.73e-04
Toll Like Receptor TLR1:TLR2 Cascade 92 1.10e-04 -0.233000 4.73e-04
Toll Like Receptor TLR6:TLR2 Cascade 92 1.10e-04 -0.233000 4.73e-04
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 2.02e-01 -0.233000 2.92e-01
Mitophagy 26 3.98e-02 -0.233000 7.73e-02
RHO GTPase Effectors 228 1.38e-09 -0.233000 2.63e-08
Plasma lipoprotein clearance 36 1.60e-02 -0.232000 3.64e-02
Plasma lipoprotein remodeling 32 2.32e-02 0.232000 4.99e-02
Class A/1 (Rhodopsin-like receptors) 297 6.57e-12 0.232000 2.04e-10
Hedgehog ‘off’ state 97 8.67e-05 -0.231000 3.84e-04
Neddylation 225 2.62e-09 -0.230000 4.64e-08
Inactivation of APC/C via direct inhibition of the APC/C complex 19 8.24e-02 -0.230000 1.42e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 8.24e-02 -0.230000 1.42e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 16 1.11e-01 -0.230000 1.81e-01
RUNX2 regulates bone development 29 3.21e-02 -0.230000 6.49e-02
Striated Muscle Contraction 33 2.23e-02 0.230000 4.83e-02
Interferon Signaling 184 8.14e-08 -0.229000 1.09e-06
ATF4 activates genes in response to endoplasmic reticulum stress 26 4.34e-02 -0.229000 8.34e-02
Cellular Senescence 122 1.30e-05 -0.229000 7.83e-05
DDX58/IFIH1-mediated induction of interferon-alpha/beta 68 1.20e-03 -0.227000 3.91e-03
Peptide hormone biosynthesis 11 1.92e-01 0.227000 2.81e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 2.15e-01 -0.226000 3.07e-01
Regulation of actin dynamics for phagocytic cup formation 58 2.96e-03 -0.226000 8.27e-03
GPCR ligand binding 421 2.39e-15 0.225000 1.30e-13
RNA Polymerase I Promoter Clearance 46 8.28e-03 -0.225000 2.05e-02
Gene expression (Transcription) 1332 7.95e-43 -0.224000 2.42e-40
Regulation of RUNX1 Expression and Activity 19 9.10e-02 -0.224000 1.55e-01
Translesion synthesis by POLI 17 1.10e-01 -0.224000 1.80e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 30 3.41e-02 -0.223000 6.81e-02
Glutamate and glutamine metabolism 12 1.81e-01 -0.223000 2.65e-01
Macroautophagy 100 1.15e-04 -0.223000 4.92e-04
DARPP-32 events 24 5.95e-02 -0.222000 1.08e-01
Peptide ligand-binding receptors 180 2.77e-07 0.222000 3.24e-06
Androgen biosynthesis 11 2.04e-01 0.221000 2.94e-01
RUNX2 regulates osteoblast differentiation 22 7.31e-02 -0.221000 1.30e-01
Peroxisomal protein import 60 3.13e-03 -0.221000 8.65e-03
Phosphorylation of CD3 and TCR zeta chains 20 8.79e-02 0.220000 1.50e-01
Regulation of PTEN stability and activity 66 1.98e-03 -0.220000 5.88e-03
Deactivation of the beta-catenin transactivating complex 38 1.92e-02 -0.220000 4.28e-02
Acyl chain remodelling of PC 25 5.78e-02 0.219000 1.06e-01
Ub-specific processing proteases 150 3.61e-06 -0.219000 2.66e-05
Cellular responses to stress 655 1.19e-21 -0.219000 1.13e-19
Transcriptional regulation by RUNX2 116 4.63e-05 -0.219000 2.25e-04
Regulation of KIT signaling 16 1.30e-01 -0.219000 2.03e-01
TP53 Regulates Metabolic Genes 71 1.46e-03 -0.218000 4.58e-03
Cross-presentation of soluble exogenous antigens (endosomes) 48 9.02e-03 -0.218000 2.22e-02
RNA Polymerase I Transcription Termination 27 5.01e-02 -0.218000 9.38e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 1.10e-01 -0.218000 1.80e-01
Hedgehog ‘on’ state 83 6.06e-04 -0.218000 2.16e-03
Synthesis of PIPs at the Golgi membrane 17 1.20e-01 -0.218000 1.92e-01
CD28 dependent PI3K/Akt signaling 22 7.75e-02 -0.217000 1.36e-01
RHOC GTPase cycle 63 2.86e-03 -0.217000 8.02e-03
Cellular responses to stimuli 669 1.06e-21 -0.217000 1.08e-19
Interleukin-7 signaling 21 8.69e-02 -0.216000 1.49e-01
Deubiquitination 222 3.02e-08 -0.216000 4.36e-07
Downregulation of TGF-beta receptor signaling 26 5.68e-02 -0.216000 1.04e-01
Antigen processing-Cross presentation 100 1.93e-04 -0.216000 7.75e-04
Positive epigenetic regulation of rRNA expression 43 1.45e-02 -0.215000 3.35e-02
RHOU GTPase cycle 35 2.75e-02 -0.215000 5.71e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 75 1.27e-03 -0.215000 4.10e-03
Infection with Mycobacterium tuberculosis 26 5.80e-02 -0.215000 1.06e-01
RHOH GTPase cycle 35 2.79e-02 -0.215000 5.77e-02
WNT ligand biogenesis and trafficking 24 6.86e-02 -0.215000 1.23e-01
Peroxisomal lipid metabolism 27 5.38e-02 -0.214000 9.94e-02
Metabolism of nitric oxide: NOS3 activation and regulation 15 1.51e-01 -0.214000 2.30e-01
RNA Polymerase II Transcription 1200 1.12e-35 -0.214000 2.43e-33
Signaling by KIT in disease 20 9.81e-02 -0.214000 1.64e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 9.81e-02 -0.214000 1.64e-01
FGFR2 mutant receptor activation 32 3.67e-02 -0.213000 7.25e-02
Regulation of TP53 Activity through Acetylation 28 5.08e-02 -0.213000 9.49e-02
Sulfur amino acid metabolism 27 5.53e-02 -0.213000 1.02e-01
Formation of TC-NER Pre-Incision Complex 50 9.21e-03 -0.213000 2.26e-02
Defective GALNT3 causes HFTC 15 1.53e-01 0.213000 2.33e-01
Cell-extracellular matrix interactions 14 1.68e-01 -0.213000 2.51e-01
Epigenetic regulation of gene expression 83 8.17e-04 -0.212000 2.78e-03
Potassium Channels 102 2.10e-04 0.212000 8.38e-04
Fcgamma receptor (FCGR) dependent phagocytosis 81 9.53e-04 -0.212000 3.19e-03
Synthesis of substrates in N-glycan biosythesis 59 4.79e-03 -0.212000 1.26e-02
NOTCH2 intracellular domain regulates transcription 11 2.23e-01 -0.212000 3.17e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 12 2.04e-01 0.212000 2.94e-01
Activation of BAD and translocation to mitochondria 15 1.55e-01 -0.212000 2.35e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 5.24e-02 -0.212000 9.72e-02
Apoptosis 163 3.16e-06 -0.212000 2.43e-05
ATF6 (ATF6-alpha) activates chaperone genes 10 2.47e-01 -0.211000 3.40e-01
Cardiac conduction 119 7.23e-05 0.211000 3.28e-04
Transport to the Golgi and subsequent modification 161 4.00e-06 -0.211000 2.88e-05
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 12 2.08e-01 0.210000 2.98e-01
B-WICH complex positively regulates rRNA expression 29 5.06e-02 -0.210000 9.46e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 1.47e-01 -0.210000 2.25e-01
Sema3A PAK dependent Axon repulsion 14 1.75e-01 -0.209000 2.60e-01
Abacavir ADME 10 2.52e-01 -0.209000 3.47e-01
Downstream TCR signaling 91 5.76e-04 -0.209000 2.06e-03
Activated NOTCH1 Transmits Signal to the Nucleus 30 4.82e-02 -0.208000 9.08e-02
Intrinsic Pathway for Apoptosis 52 9.65e-03 -0.207000 2.35e-02
HSF1-dependent transactivation 35 3.43e-02 -0.207000 6.84e-02
Butyrophilin (BTN) family interactions 12 2.16e-01 0.206000 3.09e-01
Fanconi Anemia Pathway 31 4.71e-02 -0.206000 8.95e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 1.82e-01 0.206000 2.67e-01
Ion homeostasis 49 1.28e-02 0.205000 3.00e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 2.18e-01 0.205000 3.11e-01
Dual incision in TC-NER 62 5.21e-03 -0.205000 1.36e-02
Signaling by Hedgehog 133 4.64e-05 -0.205000 2.25e-04
Metal ion SLC transporters 25 7.71e-02 -0.204000 1.35e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 2.21e-01 -0.204000 3.15e-01
Thromboxane signalling through TP receptor 24 8.49e-02 -0.203000 1.46e-01
Programmed Cell Death 190 1.47e-06 -0.203000 1.25e-05
Transcriptional regulation of testis differentiation 12 2.27e-01 0.201000 3.19e-01
Death Receptor Signalling 120 1.44e-04 -0.201000 5.95e-04
CTLA4 inhibitory signaling 21 1.11e-01 -0.201000 1.81e-01
Mitochondrial biogenesis 66 4.84e-03 -0.201000 1.27e-02
TAK1-dependent IKK and NF-kappa-B activation 23 9.60e-02 -0.201000 1.61e-01
Diseases of signal transduction by growth factor receptors and second messengers 405 4.67e-12 -0.200000 1.54e-10
Pregnenolone biosynthesis 10 2.74e-01 -0.200000 3.68e-01
Organic cation transport 10 2.74e-01 -0.200000 3.68e-01
Signaling by FLT3 fusion proteins 19 1.32e-01 -0.199000 2.07e-01
Interleukin-1 family signaling 126 1.12e-04 -0.199000 4.83e-04
NOTCH4 Intracellular Domain Regulates Transcription 19 1.33e-01 -0.199000 2.07e-01
Signaling by NOTCH1 69 4.23e-03 -0.199000 1.13e-02
G1/S-Specific Transcription 26 7.89e-02 -0.199000 1.38e-01
Meiosis 53 1.22e-02 -0.199000 2.88e-02
Retinoid metabolism and transport 41 2.76e-02 0.199000 5.73e-02
Signaling by FGFR1 in disease 36 3.91e-02 -0.199000 7.65e-02
Degradation of the extracellular matrix 103 4.96e-04 0.199000 1.79e-03
GRB2 events in EGFR signaling 12 2.34e-01 0.199000 3.26e-01
ATF6 (ATF6-alpha) activates chaperones 11 2.57e-01 -0.198000 3.51e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 1.27e-01 -0.197000 2.00e-01
Glycosphingolipid metabolism 39 3.32e-02 -0.197000 6.65e-02
RNA Polymerase I Transcription Initiation 42 2.72e-02 -0.197000 5.67e-02
Signaling by NTRKs 132 9.69e-05 -0.196000 4.26e-04
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 3.20e-02 -0.196000 6.47e-02
Meiotic synapsis 29 6.81e-02 -0.196000 1.23e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 27 7.86e-02 -0.196000 1.37e-01
Diseases of mitotic cell cycle 35 4.53e-02 -0.195000 8.65e-02
SUMOylation of transcription cofactors 43 2.68e-02 -0.195000 5.60e-02
Vitamin B5 (pantothenate) metabolism 16 1.77e-01 -0.195000 2.60e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 3.74e-02 -0.195000 7.35e-02
Phase I - Functionalization of compounds 98 8.76e-04 0.195000 2.96e-03
Autophagy 112 3.81e-04 -0.194000 1.44e-03
Tryptophan catabolism 12 2.45e-01 0.194000 3.39e-01
Interleukin-35 Signalling 12 2.45e-01 -0.194000 3.39e-01
Metabolism of Angiotensinogen to Angiotensins 15 1.94e-01 0.194000 2.83e-01
Generic Transcription Pathway 1097 4.05e-27 -0.193000 5.59e-25
E2F mediated regulation of DNA replication 14 2.11e-01 -0.193000 3.03e-01
Post-chaperonin tubulin folding pathway 21 1.26e-01 -0.193000 1.99e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 4.85e-02 -0.193000 9.11e-02
Na+/Cl- dependent neurotransmitter transporters 18 1.58e-01 0.192000 2.39e-01
C-type lectin receptors (CLRs) 131 1.49e-04 -0.192000 6.12e-04
Ovarian tumor domain proteases 36 4.66e-02 -0.192000 8.87e-02
Binding and Uptake of Ligands by Scavenger Receptors 40 3.60e-02 0.192000 7.12e-02
Metabolism of water-soluble vitamins and cofactors 111 5.04e-04 -0.191000 1.82e-03
Signaling by FGFR in disease 60 1.13e-02 -0.189000 2.68e-02
Signaling by TGFB family members 114 4.85e-04 -0.189000 1.76e-03
eNOS activation 11 2.77e-01 -0.189000 3.70e-01
Activation of the pre-replicative complex 24 1.09e-01 -0.189000 1.79e-01
IRF3-mediated induction of type I IFN 11 2.79e-01 -0.188000 3.72e-01
Retrograde neurotrophin signalling 14 2.23e-01 -0.188000 3.16e-01
PERK regulates gene expression 30 7.44e-02 -0.188000 1.31e-01
PCP/CE pathway 90 2.04e-03 -0.188000 6.03e-03
Signaling by FGFR2 in disease 42 3.50e-02 -0.188000 6.92e-02
Collagen chain trimerization 40 3.97e-02 0.188000 7.72e-02
CTNNB1 S33 mutants aren’t phosphorylated 14 2.25e-01 -0.187000 3.18e-01
CTNNB1 S37 mutants aren’t phosphorylated 14 2.25e-01 -0.187000 3.18e-01
CTNNB1 S45 mutants aren’t phosphorylated 14 2.25e-01 -0.187000 3.18e-01
CTNNB1 T41 mutants aren’t phosphorylated 14 2.25e-01 -0.187000 3.18e-01
Signaling by CTNNB1 phospho-site mutants 14 2.25e-01 -0.187000 3.18e-01
Signaling by GSK3beta mutants 14 2.25e-01 -0.187000 3.18e-01
Cell-cell junction organization 56 1.54e-02 0.187000 3.53e-02
Acetylcholine Neurotransmitter Release Cycle 16 1.95e-01 0.187000 2.84e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 1.70e-01 -0.187000 2.54e-01
trans-Golgi Network Vesicle Budding 65 9.28e-03 -0.187000 2.27e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.64e-01 -0.186000 3.56e-01
alpha-linolenic acid (ALA) metabolism 12 2.64e-01 -0.186000 3.56e-01
TGF-beta receptor signaling activates SMADs 45 3.08e-02 -0.186000 6.31e-02
Listeria monocytogenes entry into host cells 19 1.61e-01 -0.186000 2.43e-01
STING mediated induction of host immune responses 13 2.47e-01 -0.185000 3.40e-01
ABC-family proteins mediated transport 98 1.52e-03 -0.185000 4.71e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 2.30e-01 -0.185000 3.22e-01
p38MAPK events 13 2.48e-01 -0.185000 3.41e-01
Elevation of cytosolic Ca2+ levels 16 2.02e-01 -0.184000 2.92e-01
PI-3K cascade:FGFR4 19 1.65e-01 -0.184000 2.47e-01
Chemokine receptors bind chemokines 52 2.17e-02 0.184000 4.76e-02
MTOR signalling 35 6.13e-02 -0.183000 1.12e-01
PI-3K cascade:FGFR3 17 1.94e-01 -0.182000 2.82e-01
ADORA2B mediated anti-inflammatory cytokines production 132 3.16e-04 0.182000 1.22e-03
HDL remodeling 10 3.20e-01 0.182000 4.17e-01
Membrane Trafficking 563 1.89e-13 -0.181000 7.77e-12
TRAF3-dependent IRF activation pathway 14 2.40e-01 -0.181000 3.34e-01
Bile acid and bile salt metabolism 43 3.98e-02 0.181000 7.73e-02
Glycogen storage diseases 14 2.41e-01 -0.181000 3.35e-01
Adenylate cyclase inhibitory pathway 14 2.42e-01 0.181000 3.36e-01
CD209 (DC-SIGN) signaling 20 1.62e-01 -0.181000 2.44e-01
Infectious disease 862 2.98e-19 -0.180000 2.38e-17
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 13 2.61e-01 -0.180000 3.55e-01
Synthesis of IP3 and IP4 in the cytosol 25 1.20e-01 0.180000 1.92e-01
APC truncation mutants have impaired AXIN binding 13 2.64e-01 -0.179000 3.56e-01
AXIN missense mutants destabilize the destruction complex 13 2.64e-01 -0.179000 3.56e-01
Signaling by AMER1 mutants 13 2.64e-01 -0.179000 3.56e-01
Signaling by APC mutants 13 2.64e-01 -0.179000 3.56e-01
Signaling by AXIN mutants 13 2.64e-01 -0.179000 3.56e-01
Truncations of AMER1 destabilize the destruction complex 13 2.64e-01 -0.179000 3.56e-01
G alpha (i) signalling events 293 1.39e-07 0.179000 1.77e-06
Biological oxidations 210 8.01e-06 0.179000 5.12e-05
Erythropoietin activates RAS 14 2.47e-01 -0.179000 3.40e-01
Signaling by Leptin 11 3.07e-01 -0.178000 4.03e-01
TNFR2 non-canonical NF-kB pathway 93 3.11e-03 -0.177000 8.61e-03
Cytoprotection by HMOX1 55 2.29e-02 -0.177000 4.93e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 34 7.35e-02 -0.177000 1.30e-01
Signaling by Rho GTPases 565 7.26e-13 -0.177000 2.69e-11
Synthesis of PA 34 7.56e-02 0.176000 1.33e-01
Glyoxylate metabolism and glycine degradation 29 1.02e-01 -0.176000 1.68e-01
Inflammasomes 21 1.64e-01 -0.175000 2.46e-01
Amino acids regulate mTORC1 44 4.42e-02 -0.175000 8.47e-02
EPH-Ephrin signaling 89 4.30e-03 -0.175000 1.15e-02
Transcriptional regulation by RUNX1 169 8.66e-05 -0.175000 3.84e-04
Acyl chain remodelling of PE 23 1.47e-01 0.175000 2.25e-01
PTEN Regulation 141 3.39e-04 -0.175000 1.31e-03
RUNX3 regulates NOTCH signaling 13 2.76e-01 -0.175000 3.69e-01
Metabolism of proteins 1717 4.67e-33 -0.174000 8.87e-31
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 579 1.00e-12 -0.173000 3.54e-11
ADP signalling through P2Y purinoceptor 1 25 1.34e-01 -0.173000 2.09e-01
Other semaphorin interactions 18 2.04e-01 0.173000 2.94e-01
RHOF GTPase cycle 37 6.92e-02 -0.173000 1.24e-01
Maturation of nucleoprotein 11 3.25e-01 -0.172000 4.22e-01
Activation of AMPK downstream of NMDARs 10 3.49e-01 0.171000 4.46e-01
Cargo trafficking to the periciliary membrane 48 4.07e-02 -0.171000 7.89e-02
RHOB GTPase cycle 60 2.23e-02 -0.171000 4.83e-02
Muscle contraction 185 6.36e-05 0.170000 2.92e-04
TCR signaling 111 1.94e-03 -0.170000 5.78e-03
ESR-mediated signaling 155 2.63e-04 -0.170000 1.04e-03
Advanced glycosylation endproduct receptor signaling 13 2.91e-01 -0.169000 3.85e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 1.79e-01 0.169000 2.63e-01
Antigen processing: Ubiquitination & Proteasome degradation 286 8.68e-07 -0.169000 8.25e-06
Regulation of IFNA/IFNB signaling 16 2.43e-01 -0.169000 3.37e-01
NCAM1 interactions 35 8.48e-02 0.168000 1.46e-01
Downstream signaling of activated FGFR4 26 1.39e-01 -0.168000 2.15e-01
Interleukin-37 signaling 19 2.06e-01 -0.167000 2.97e-01
Cellular response to chemical stress 182 9.97e-05 -0.167000 4.37e-04
Lysosome Vesicle Biogenesis 33 9.64e-02 -0.167000 1.62e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 3.64e-01 0.166000 4.63e-01
RHOBTB1 GTPase cycle 22 1.79e-01 -0.166000 2.62e-01
Downstream signaling of activated FGFR3 24 1.62e-01 -0.165000 2.43e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 3.23e-01 -0.165000 4.20e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 1.63e-01 0.165000 2.44e-01
Regulation of TLR by endogenous ligand 17 2.40e-01 0.164000 3.35e-01
Metabolism of cofactors 19 2.15e-01 -0.164000 3.07e-01
GRB2 events in ERBB2 signaling 16 2.56e-01 0.164000 3.50e-01
Golgi Associated Vesicle Biogenesis 49 4.82e-02 -0.163000 9.08e-02
TNFs bind their physiological receptors 24 1.67e-01 0.163000 2.49e-01
Formation of Incision Complex in GG-NER 40 7.46e-02 -0.163000 1.32e-01
RHOG GTPase cycle 64 2.45e-02 -0.163000 5.19e-02
Diseases of carbohydrate metabolism 30 1.23e-01 -0.162000 1.96e-01
Interconversion of nucleotide di- and triphosphates 24 1.69e-01 -0.162000 2.52e-01
Class I MHC mediated antigen processing & presentation 353 1.71e-07 -0.162000 2.13e-06
Beta-catenin phosphorylation cascade 16 2.62e-01 -0.162000 3.56e-01
FCERI mediated Ca+2 mobilization 27 1.46e-01 -0.162000 2.24e-01
Regulation of BACH1 activity 14 2.95e-01 -0.162000 3.90e-01
GPCR downstream signalling 581 2.95e-11 0.162000 8.46e-10
Thrombin signalling through proteinase activated receptors (PARs) 32 1.14e-01 -0.161000 1.84e-01
Signal attenuation 10 3.77e-01 -0.161000 4.77e-01
RHO GTPases activate PKNs 34 1.04e-01 -0.161000 1.72e-01
FLT3 Signaling 38 8.69e-02 -0.160000 1.49e-01
G beta:gamma signalling through CDC42 19 2.27e-01 -0.160000 3.19e-01
Factors involved in megakaryocyte development and platelet production 120 2.51e-03 -0.160000 7.14e-03
Neuronal System 371 1.30e-07 0.160000 1.66e-06
Regulation of MECP2 expression and activity 26 1.59e-01 -0.159000 2.41e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 2.29e-01 -0.159000 3.22e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 2.29e-01 -0.159000 3.22e-01
WNT5A-dependent internalization of FZD4 15 2.87e-01 -0.159000 3.80e-01
Recycling pathway of L1 22 1.97e-01 -0.159000 2.85e-01
Phase II - Conjugation of compounds 105 4.91e-03 0.159000 1.29e-02
Signaling by NOTCH 176 2.82e-04 -0.159000 1.10e-03
Gap junction trafficking and regulation 29 1.40e-01 0.158000 2.17e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 100 6.51e-03 0.157000 1.65e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 1.73e-01 0.157000 2.57e-01
Gluconeogenesis 32 1.24e-01 -0.157000 1.96e-01
Repression of WNT target genes 13 3.29e-01 -0.156000 4.25e-01
Signal amplification 33 1.21e-01 -0.156000 1.93e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 3.14e-01 -0.155000 4.11e-01
FRS-mediated FGFR4 signaling 21 2.18e-01 -0.155000 3.11e-01
Defective B4GALT7 causes EDS, progeroid type 17 2.70e-01 0.155000 3.63e-01
Vesicle-mediated transport 600 1.05e-10 -0.154000 2.76e-09
Gap junction trafficking 27 1.65e-01 0.154000 2.47e-01
Post-translational protein modification 1243 8.40e-20 -0.154000 7.10e-18
Translocation of ZAP-70 to Immunological synapse 17 2.72e-01 0.154000 3.66e-01
TCF dependent signaling in response to WNT 167 6.11e-04 -0.154000 2.17e-03
PIP3 activates AKT signaling 264 1.81e-05 -0.153000 1.02e-04
EPHA-mediated growth cone collapse 15 3.05e-01 -0.153000 4.02e-01
Notch-HLH transcription pathway 24 1.95e-01 -0.153000 2.84e-01
Platelet Aggregation (Plug Formation) 37 1.08e-01 0.153000 1.77e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 2.75e-01 0.153000 3.69e-01
O-linked glycosylation 96 9.77e-03 0.153000 2.38e-02
Downstream signal transduction 29 1.55e-01 -0.152000 2.35e-01
Interleukin-12 signaling 43 8.41e-02 -0.152000 1.45e-01
Organic cation/anion/zwitterion transport 15 3.07e-01 0.152000 4.04e-01
Metabolism of nucleotides 87 1.45e-02 -0.152000 3.35e-02
Post NMDA receptor activation events 58 4.60e-02 0.151000 8.77e-02
RAC2 GTPase cycle 74 2.44e-02 -0.151000 5.19e-02
SUMOylation of DNA methylation proteins 16 2.95e-01 -0.151000 3.90e-01
Nucleotide biosynthesis 14 3.29e-01 -0.151000 4.25e-01
FRS-mediated FGFR3 signaling 19 2.56e-01 -0.151000 3.50e-01
Signaling by SCF-KIT 43 8.81e-02 -0.150000 1.50e-01
RND3 GTPase cycle 40 1.01e-01 -0.150000 1.68e-01
Neurexins and neuroligins 52 6.25e-02 0.149000 1.13e-01
Ion transport by P-type ATPases 50 7.09e-02 0.148000 1.27e-01
The NLRP3 inflammasome 16 3.07e-01 -0.148000 4.03e-01
Signaling by GPCR 640 2.25e-10 0.147000 5.35e-09
Uptake and function of anthrax toxins 11 4.00e-01 0.147000 4.99e-01
G-protein activation 24 2.14e-01 -0.147000 3.06e-01
Late endosomal microautophagy 29 1.73e-01 -0.146000 2.56e-01
FOXO-mediated transcription of cell cycle genes 16 3.12e-01 -0.146000 4.09e-01
Extracellular matrix organization 276 3.06e-05 0.146000 1.59e-04
G alpha (q) signalling events 200 3.79e-04 0.146000 1.43e-03
EPH-ephrin mediated repulsion of cells 48 8.05e-02 -0.146000 1.40e-01
Metabolism of fat-soluble vitamins 45 9.15e-02 0.145000 1.55e-01
Sphingolipid metabolism 72 3.30e-02 -0.145000 6.62e-02
Heme biosynthesis 13 3.65e-01 -0.145000 4.64e-01
GABA receptor activation 57 5.85e-02 0.145000 1.07e-01
Prostacyclin signalling through prostacyclin receptor 19 2.77e-01 -0.144000 3.70e-01
TP53 Regulates Transcription of Cell Death Genes 41 1.12e-01 -0.143000 1.83e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 4.11e-01 0.143000 5.11e-01
RHOD GTPase cycle 45 9.68e-02 -0.143000 1.62e-01
Ethanol oxidation 11 4.12e-01 -0.143000 5.12e-01
Signaling by FLT3 ITD and TKD mutants 16 3.23e-01 -0.143000 4.20e-01
G alpha (s) signalling events 152 2.45e-03 0.142000 7.04e-03
RND1 GTPase cycle 40 1.20e-01 -0.142000 1.92e-01
p75 NTR receptor-mediated signalling 83 2.61e-02 -0.141000 5.47e-02
PI-3K cascade:FGFR1 21 2.65e-01 -0.140000 3.57e-01
Sensory processing of sound by outer hair cells of the cochlea 46 1.01e-01 0.140000 1.68e-01
Assembly of collagen fibrils and other multimeric structures 52 8.14e-02 0.140000 1.41e-01
Downstream signaling of activated FGFR1 31 1.80e-01 -0.139000 2.64e-01
Signalling to ERKs 34 1.61e-01 -0.139000 2.42e-01
RHOA GTPase cycle 128 6.71e-03 -0.139000 1.70e-02
Termination of O-glycan biosynthesis 22 2.60e-01 0.139000 3.54e-01
Signaling by Non-Receptor Tyrosine Kinases 53 8.13e-02 -0.138000 1.41e-01
Signaling by PTK6 53 8.13e-02 -0.138000 1.41e-01
Dermatan sulfate biosynthesis 10 4.49e-01 0.138000 5.43e-01
Sema4D induced cell migration and growth-cone collapse 20 2.84e-01 -0.138000 3.78e-01
RND2 GTPase cycle 40 1.30e-01 -0.138000 2.04e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 117 9.85e-03 0.138000 2.39e-02
G beta:gamma signalling through BTK 17 3.25e-01 -0.138000 4.22e-01
Neurotransmitter receptors and postsynaptic signal transmission 175 1.68e-03 0.138000 5.11e-03
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 1.49e-01 -0.137000 2.27e-01
Regulation of localization of FOXO transcription factors 10 4.53e-01 -0.137000 5.47e-01
Anti-inflammatory response favouring Leishmania parasite infection 164 2.50e-03 0.137000 7.13e-03
Leishmania parasite growth and survival 164 2.50e-03 0.137000 7.13e-03
Assembly Of The HIV Virion 14 3.77e-01 -0.136000 4.77e-01
Triglyceride biosynthesis 12 4.15e-01 0.136000 5.14e-01
Transcriptional Regulation by VENTX 36 1.60e-01 -0.135000 2.42e-01
Signalling to RAS 20 2.95e-01 -0.135000 3.90e-01
Fatty acyl-CoA biosynthesis 31 1.95e-01 -0.135000 2.83e-01
Assembly and cell surface presentation of NMDA receptors 23 2.64e-01 0.135000 3.56e-01
FGFR2c ligand binding and activation 12 4.20e-01 -0.134000 5.19e-01
Disease 1582 6.20e-19 -0.134000 4.72e-17
Sema4D in semaphorin signaling 23 2.65e-01 -0.134000 3.57e-01
Presynaptic depolarization and calcium channel opening 12 4.22e-01 0.134000 5.20e-01
Metabolism of carbohydrates 266 1.72e-04 -0.134000 6.94e-04
PI-3K cascade:FGFR2 22 2.78e-01 -0.134000 3.71e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 4.65e-01 0.133000 5.58e-01
Collagen degradation 36 1.66e-01 0.133000 2.49e-01
FOXO-mediated transcription of cell death genes 15 3.76e-01 -0.132000 4.76e-01
RHO GTPase cycle 399 6.26e-06 -0.132000 4.14e-05
Cytokine Signaling in Immune system 641 1.35e-08 -0.132000 2.08e-07
Downstream signaling of activated FGFR2 29 2.21e-01 -0.131000 3.15e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 4.13e-01 -0.131000 5.13e-01
Signaling by NTRK2 (TRKB) 25 2.56e-01 -0.131000 3.50e-01
Diseases of programmed cell death 41 1.46e-01 -0.131000 2.25e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 2.89e-01 -0.131000 3.83e-01
Cell recruitment (pro-inflammatory response) 25 2.58e-01 -0.131000 3.53e-01
Purinergic signaling in leishmaniasis infection 25 2.58e-01 -0.131000 3.53e-01
Transmission across Chemical Synapses 237 5.52e-04 0.130000 1.98e-03
Processing and activation of SUMO 10 4.76e-01 -0.130000 5.72e-01
RAF activation 33 1.96e-01 -0.130000 2.85e-01
Sensory processing of sound 66 6.92e-02 0.129000 1.24e-01
Axon guidance 497 8.15e-07 -0.129000 7.84e-06
Pyrimidine catabolism 11 4.60e-01 0.129000 5.54e-01
VEGFA-VEGFR2 Pathway 92 3.38e-02 -0.128000 6.75e-02
Nervous system development 519 6.13e-07 -0.128000 6.21e-06
Intracellular signaling by second messengers 302 1.34e-04 -0.128000 5.62e-04
Metabolism of amino acids and derivatives 339 5.34e-05 -0.128000 2.53e-04
Downregulation of ERBB2 signaling 28 2.43e-01 -0.127000 3.37e-01
Uptake and actions of bacterial toxins 29 2.36e-01 0.127000 3.30e-01
RA biosynthesis pathway 21 3.14e-01 0.127000 4.11e-01
Regulation of FZD by ubiquitination 21 3.16e-01 -0.126000 4.12e-01
Beta-catenin independent WNT signaling 140 9.79e-03 -0.126000 2.38e-02
Triglyceride metabolism 34 2.03e-01 0.126000 2.92e-01
Circadian Clock 67 7.42e-02 -0.126000 1.31e-01
Interleukin-12 family signaling 53 1.15e-01 -0.125000 1.86e-01
Signaling by MET 66 7.95e-02 -0.125000 1.39e-01
GPVI-mediated activation cascade 32 2.23e-01 -0.124000 3.16e-01
Signaling by WNT 257 6.44e-04 -0.124000 2.28e-03
Clathrin-mediated endocytosis 134 1.43e-02 -0.123000 3.31e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 4.13e-01 0.122000 5.13e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 3.45e-01 -0.122000 4.41e-01
Effects of PIP2 hydrolysis 26 2.83e-01 -0.122000 3.77e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 115 2.45e-02 0.121000 5.19e-02
Formation of the beta-catenin:TCF transactivating complex 31 2.43e-01 -0.121000 3.37e-01
Triglyceride catabolism 22 3.26e-01 0.121000 4.23e-01
Signaling by Receptor Tyrosine Kinases 485 5.28e-06 -0.121000 3.60e-05
ROS and RNS production in phagocytes 35 2.17e-01 0.121000 3.09e-01
PD-1 signaling 21 3.40e-01 0.120000 4.37e-01
ERBB2 Regulates Cell Motility 15 4.23e-01 0.119000 5.21e-01
FRS-mediated FGFR1 signaling 23 3.27e-01 -0.118000 4.24e-01
Extra-nuclear estrogen signaling 72 8.34e-02 -0.118000 1.44e-01
Synthesis of PC 27 2.90e-01 -0.118000 3.84e-01
Ion channel transport 157 1.11e-02 0.118000 2.64e-02
Membrane binding and targetting of GAG proteins 12 4.81e-01 -0.117000 5.76e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 4.81e-01 -0.117000 5.76e-01
Interleukin-27 signaling 11 5.01e-01 -0.117000 5.93e-01
Disorders of transmembrane transporters 166 9.22e-03 -0.117000 2.26e-02
TRAF6 mediated IRF7 activation 20 3.66e-01 -0.117000 4.65e-01
Stimuli-sensing channels 86 6.22e-02 0.116000 1.13e-01
Dectin-2 family 24 3.27e-01 0.115000 4.24e-01
RHO GTPases activate PAKs 19 3.84e-01 -0.115000 4.85e-01
Response to metal ions 14 4.59e-01 -0.114000 5.53e-01
Signaling by VEGF 100 4.85e-02 -0.114000 9.11e-02
GABA synthesis, release, reuptake and degradation 19 3.91e-01 0.114000 4.92e-01
SLC-mediated transmembrane transport 235 2.72e-03 0.114000 7.66e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 4.20e-01 -0.113000 5.18e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 4.20e-01 -0.113000 5.18e-01
SUMOylation of immune response proteins 10 5.36e-01 -0.113000 6.27e-01
FRS-mediated FGFR2 signaling 24 3.40e-01 -0.113000 4.37e-01
G beta:gamma signalling through PI3Kgamma 25 3.32e-01 -0.112000 4.28e-01
Signaling by Nuclear Receptors 231 3.39e-03 -0.112000 9.29e-03
IL-6-type cytokine receptor ligand interactions 17 4.25e-01 0.112000 5.21e-01
Energy dependent regulation of mTOR by LKB1-AMPK 23 3.57e-01 -0.111000 4.55e-01
FCGR activation 12 5.06e-01 -0.111000 5.98e-01
Detoxification of Reactive Oxygen Species 34 2.65e-01 0.111000 3.57e-01
Integrin cell surface interactions 66 1.21e-01 0.110000 1.93e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.46e-01 -0.110000 6.35e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 25 3.41e-01 -0.110000 4.37e-01
Costimulation by the CD28 family 65 1.26e-01 -0.110000 1.99e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 4.94e-01 -0.110000 5.87e-01
SHC1 events in EGFR signaling 13 4.94e-01 0.110000 5.87e-01
Activation of BH3-only proteins 30 3.00e-01 -0.109000 3.95e-01
Signaling by Interleukins 411 1.45e-04 -0.109000 5.97e-04
Tight junction interactions 28 3.18e-01 0.109000 4.15e-01
Interleukin-15 signaling 13 4.96e-01 -0.109000 5.89e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 5.36e-01 -0.108000 6.27e-01
Transcriptional regulation of white adipocyte differentiation 79 9.95e-02 -0.107000 1.66e-01
MHC class II antigen presentation 102 6.14e-02 -0.107000 1.12e-01
Sensory processing of sound by inner hair cells of the cochlea 61 1.48e-01 0.107000 2.26e-01
MyD88 deficiency (TLR2/4) 16 4.59e-01 0.107000 5.53e-01
Signaling by PDGFRA extracellular domain mutants 12 5.25e-01 -0.106000 6.16e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 5.25e-01 -0.106000 6.16e-01
ADP signalling through P2Y purinoceptor 12 22 3.90e-01 -0.106000 4.91e-01
Activation of NMDA receptors and postsynaptic events 69 1.28e-01 0.106000 2.01e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 4.53e-01 -0.105000 5.47e-01
FGFR2 ligand binding and activation 19 4.28e-01 -0.105000 5.24e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 3.74e-01 -0.105000 4.74e-01
Cargo concentration in the ER 31 3.18e-01 -0.104000 4.15e-01
Collagen biosynthesis and modifying enzymes 58 1.73e-01 0.103000 2.57e-01
Iron uptake and transport 57 1.77e-01 -0.103000 2.60e-01
Arachidonic acid metabolism 56 1.82e-01 0.103000 2.66e-01
Metabolism of vitamins and cofactors 173 1.93e-02 -0.103000 4.30e-02
RAC3 GTPase cycle 78 1.16e-01 -0.103000 1.86e-01
EGFR downregulation 29 3.39e-01 -0.103000 4.37e-01
Mitochondrial Fatty Acid Beta-Oxidation 33 3.10e-01 -0.102000 4.07e-01
PI3K/AKT Signaling in Cancer 101 7.77e-02 -0.102000 1.36e-01
Receptor-type tyrosine-protein phosphatases 16 4.82e-01 0.101000 5.76e-01
Signaling by NOTCH3 47 2.29e-01 -0.101000 3.22e-01
Pyrimidine salvage 10 5.82e-01 -0.101000 6.69e-01
RHOJ GTPase cycle 48 2.28e-01 -0.101000 3.20e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 3.41e-01 -0.100000 4.37e-01
Other interleukin signaling 22 4.16e-01 0.100000 5.14e-01
Signaling by EGFR 48 2.32e-01 -0.099700 3.25e-01
Collagen formation 78 1.30e-01 0.099300 2.03e-01
PI Metabolism 79 1.28e-01 -0.099100 2.01e-01
Class B/2 (Secretin family receptors) 90 1.05e-01 0.098800 1.73e-01
Keratan sulfate/keratin metabolism 30 3.50e-01 -0.098600 4.47e-01
Regulation of gene expression in beta cells 21 4.35e-01 0.098400 5.29e-01
SUMOylation of intracellular receptors 29 3.60e-01 -0.098200 4.58e-01
Signaling by PDGFR in disease 20 4.47e-01 -0.098200 5.41e-01
PI3K events in ERBB2 signaling 16 4.98e-01 0.097900 5.90e-01
VEGFR2 mediated vascular permeability 26 3.88e-01 -0.097800 4.90e-01
FGFR3 ligand binding and activation 12 5.58e-01 -0.097600 6.48e-01
FGFR3c ligand binding and activation 12 5.58e-01 -0.097600 6.48e-01
PI3K events in ERBB4 signaling 10 5.93e-01 0.097600 6.78e-01
Post-translational protein phosphorylation 98 9.53e-02 0.097500 1.60e-01
SHC-mediated cascade:FGFR4 19 4.62e-01 -0.097400 5.56e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.99e-01 -0.097400 4.99e-01
Metabolic disorders of biological oxidation enzymes 32 3.40e-01 0.097400 4.37e-01
Chondroitin sulfate biosynthesis 18 4.78e-01 -0.096600 5.73e-01
Transport of bile salts and organic acids, metal ions and amine compounds 84 1.27e-01 0.096400 1.99e-01
RHOQ GTPase cycle 53 2.25e-01 -0.096300 3.18e-01
RHO GTPases activate IQGAPs 11 5.82e-01 -0.095800 6.69e-01
Signaling by ERBB2 49 2.47e-01 -0.095700 3.40e-01
FGFR1c ligand binding and activation 11 5.83e-01 -0.095600 6.69e-01
Signaling by activated point mutants of FGFR1 11 5.83e-01 -0.095600 6.69e-01
Hyaluronan uptake and degradation 11 5.84e-01 -0.095400 6.70e-01
Role of LAT2/NTAL/LAB on calcium mobilization 13 5.52e-01 -0.095300 6.41e-01
Cell death signalling via NRAGE, NRIF and NADE 63 1.91e-01 -0.095200 2.80e-01
p130Cas linkage to MAPK signaling for integrins 15 5.24e-01 0.094900 6.16e-01
Signaling by EGFR in Cancer 24 4.21e-01 -0.094900 5.19e-01
Insulin receptor signalling cascade 53 2.33e-01 -0.094800 3.25e-01
Cargo recognition for clathrin-mediated endocytosis 97 1.07e-01 -0.094600 1.76e-01
Interleukin-10 signaling 43 2.83e-01 0.094600 3.77e-01
Receptor Mediated Mitophagy 10 6.07e-01 -0.093900 6.90e-01
Cell junction organization 78 1.58e-01 0.092500 2.39e-01
Pyroptosis 25 4.24e-01 -0.092400 5.21e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 5.96e-01 -0.092300 6.80e-01
Adaptive Immune System 697 3.73e-05 -0.091800 1.87e-04
Diseases associated with the TLR signaling cascade 29 3.93e-01 -0.091600 4.94e-01
Diseases of Immune System 29 3.93e-01 -0.091600 4.94e-01
RAS processing 16 5.28e-01 -0.091200 6.19e-01
Synthesis, secretion, and deacylation of Ghrelin 19 4.93e-01 0.090900 5.86e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 6.19e-01 -0.090700 7.03e-01
Transport of vitamins, nucleosides, and related molecules 38 3.34e-01 0.090500 4.31e-01
Free fatty acids regulate insulin secretion 10 6.20e-01 -0.090500 7.04e-01
PI3K Cascade 43 3.06e-01 -0.090200 4.03e-01
PIWI-interacting RNA (piRNA) biogenesis 28 4.09e-01 -0.090200 5.09e-01
Platelet Adhesion to exposed collagen 13 5.77e-01 0.089300 6.65e-01
DCC mediated attractive signaling 14 5.63e-01 0.089300 6.52e-01
Protein-protein interactions at synapses 78 1.73e-01 0.089200 2.57e-01
ECM proteoglycans 55 2.53e-01 0.089200 3.47e-01
Interferon gamma signaling 89 1.48e-01 -0.088800 2.26e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 2.82e-01 -0.087900 3.76e-01
Neutrophil degranulation 443 1.57e-03 -0.087700 4.84e-03
Semaphorin interactions 60 2.42e-01 -0.087300 3.36e-01
Activation of the TFAP2 (AP-2) family of transcription factors 11 6.19e-01 -0.086600 7.03e-01
Platelet degranulation 114 1.13e-01 0.085900 1.84e-01
Transcriptional regulation of pluripotent stem cells 29 4.24e-01 0.085800 5.21e-01
Negative regulation of the PI3K/AKT network 110 1.20e-01 -0.085800 1.92e-01
Metallothioneins bind metals 11 6.23e-01 -0.085600 7.05e-01
SHC-mediated cascade:FGFR3 17 5.42e-01 -0.085400 6.32e-01
Glucagon-type ligand receptors 33 3.99e-01 0.084700 4.99e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 3.44e-01 -0.084400 4.40e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 103 1.40e-01 -0.084300 2.16e-01
IGF1R signaling cascade 51 2.99e-01 -0.084100 3.94e-01
Sphingolipid de novo biosynthesis 33 4.05e-01 -0.083700 5.05e-01
Scavenging by Class A Receptors 19 5.28e-01 0.083600 6.19e-01
Synthesis of bile acids and bile salts 34 3.99e-01 0.083600 4.99e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 24 4.83e-01 -0.082800 5.76e-01
Metabolism 1890 3.42e-09 -0.082400 5.91e-08
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 6.36e-01 -0.082300 7.15e-01
GAB1 signalosome 16 5.73e-01 0.081400 6.61e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 5.89e-01 0.080600 6.75e-01
Signaling by PDGF 51 3.25e-01 -0.079600 4.22e-01
MAPK family signaling cascades 300 1.85e-02 -0.079100 4.16e-02
Azathioprine ADME 22 5.22e-01 -0.078900 6.15e-01
Response to elevated platelet cytosolic Ca2+ 119 1.38e-01 0.078700 2.14e-01
G-protein beta:gamma signalling 30 4.58e-01 -0.078300 5.52e-01
mRNA Editing 10 6.69e-01 0.078100 7.42e-01
Regulation of beta-cell development 41 3.89e-01 0.077700 4.91e-01
Diseases associated with glycosaminoglycan metabolism 36 4.21e-01 0.077500 5.19e-01
Signal regulatory protein family interactions 13 6.29e-01 -0.077400 7.11e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 6.44e-01 0.077100 7.21e-01
Defective EXT2 causes exostoses 2 12 6.44e-01 0.077100 7.21e-01
Ca-dependent events 35 4.31e-01 0.077000 5.25e-01
CaM pathway 33 4.46e-01 0.076700 5.40e-01
Calmodulin induced events 33 4.46e-01 0.076700 5.40e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 6.34e-01 -0.076300 7.12e-01
CaMK IV-mediated phosphorylation of CREB 10 6.77e-01 0.076200 7.47e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 5.03e-01 0.075800 5.95e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 6.78e-01 0.075800 7.48e-01
Signaling by Erythropoietin 25 5.15e-01 -0.075300 6.06e-01
Interleukin-6 family signaling 24 5.24e-01 -0.075200 6.16e-01
PKMTs methylate histone lysines 32 4.65e-01 -0.074600 5.58e-01
Regulation of signaling by NODAL 11 6.68e-01 0.074600 7.42e-01
Molecules associated with elastic fibres 30 4.81e-01 0.074300 5.76e-01
Basigin interactions 24 5.30e-01 -0.074100 6.20e-01
A tetrasaccharide linker sequence is required for GAG synthesis 23 5.39e-01 0.074000 6.29e-01
VxPx cargo-targeting to cilium 20 5.67e-01 0.073900 6.55e-01
Interleukin-2 family signaling 39 4.25e-01 -0.073800 5.22e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 6.33e-01 0.073700 7.12e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 19 5.80e-01 -0.073300 6.68e-01
Signaling by FGFR3 in disease 21 5.63e-01 -0.072900 6.52e-01
CDC42 GTPase cycle 132 1.48e-01 -0.072900 2.26e-01
Generation of second messenger molecules 30 4.91e-01 0.072700 5.85e-01
Neurotoxicity of clostridium toxins 10 6.92e-01 0.072200 7.58e-01
Interleukin-4 and Interleukin-13 signaling 102 2.08e-01 -0.072200 2.98e-01
DAP12 signaling 28 5.09e-01 -0.072100 6.00e-01
Interleukin receptor SHC signaling 23 5.50e-01 -0.072100 6.39e-01
IRS-mediated signalling 47 3.99e-01 -0.071100 4.99e-01
Neurotransmitter release cycle 47 4.00e-01 0.070900 5.00e-01
FOXO-mediated transcription 64 3.29e-01 -0.070500 4.25e-01
Vasopressin regulates renal water homeostasis via Aquaporins 42 4.29e-01 -0.070500 5.24e-01
NCAM signaling for neurite out-growth 56 3.62e-01 0.070400 4.61e-01
Keratan sulfate biosynthesis 25 5.44e-01 -0.070100 6.33e-01
Apoptotic execution phase 42 4.32e-01 -0.070100 5.26e-01
Tie2 Signaling 18 6.07e-01 -0.070000 6.90e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 15 6.39e-01 0.069900 7.17e-01
GPER1 signaling 43 4.29e-01 -0.069700 5.24e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 6.64e-01 -0.069700 7.37e-01
NR1H2 and NR1H3-mediated signaling 49 3.99e-01 0.069600 4.99e-01
MAPK1/MAPK3 signaling 263 5.29e-02 -0.069400 9.79e-02
Nucleotide catabolism 32 4.98e-01 -0.069300 5.90e-01
Activation of GABAB receptors 43 4.33e-01 0.069100 5.27e-01
GABA B receptor activation 43 4.33e-01 0.069100 5.27e-01
Sialic acid metabolism 33 4.92e-01 -0.069000 5.86e-01
Miscellaneous transport and binding events 20 5.93e-01 -0.068900 6.78e-01
Metabolism of porphyrins 27 5.40e-01 0.068100 6.30e-01
Mucopolysaccharidoses 10 7.10e-01 -0.067900 7.75e-01
Carboxyterminal post-translational modifications of tubulin 35 4.90e-01 -0.067400 5.85e-01
Aspartate and asparagine metabolism 12 6.88e-01 -0.067000 7.56e-01
IRAK4 deficiency (TLR2/4) 17 6.33e-01 0.066900 7.12e-01
Reactions specific to the complex N-glycan synthesis pathway 10 7.15e-01 0.066700 7.80e-01
IRS-related events triggered by IGF1R 50 4.15e-01 -0.066600 5.14e-01
FGFR4 ligand binding and activation 13 6.78e-01 -0.066400 7.48e-01
RHO GTPases Activate NADPH Oxidases 22 5.90e-01 0.066400 6.75e-01
SHC1 events in ERBB2 signaling 22 5.97e-01 0.065000 6.81e-01
Phospholipid metabolism 189 1.26e-01 -0.064500 1.99e-01
Nuclear Receptor transcription pathway 51 4.30e-01 -0.063900 5.24e-01
Signaling by BMP 27 5.65e-01 0.063900 6.54e-01
Innate Immune System 952 8.65e-04 -0.063800 2.93e-03
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 52 4.27e-01 -0.063700 5.23e-01
Keratan sulfate degradation 10 7.28e-01 -0.063500 7.90e-01
Peptide hormone metabolism 80 3.33e-01 0.062600 4.30e-01
G alpha (z) signalling events 48 4.55e-01 0.062400 5.49e-01
SHC-mediated cascade:FGFR1 21 6.22e-01 -0.062200 7.05e-01
Immune System 1803 1.51e-05 -0.061600 8.91e-05
RORA activates gene expression 16 6.71e-01 0.061300 7.43e-01
Defective B3GAT3 causes JDSSDHD 17 6.62e-01 0.061300 7.36e-01
PKA activation 18 6.54e-01 0.061100 7.29e-01
Caspase-mediated cleavage of cytoskeletal proteins 11 7.28e-01 -0.060500 7.90e-01
Signaling by ERBB2 TMD/JMD mutants 21 6.31e-01 0.060500 7.12e-01
Mitochondrial calcium ion transport 16 6.76e-01 -0.060400 7.47e-01
G beta:gamma signalling through PLC beta 20 6.44e-01 -0.059700 7.21e-01
RAF/MAP kinase cascade 257 1.01e-01 -0.059400 1.68e-01
Signaling by NODAL 22 6.30e-01 -0.059200 7.11e-01
SHC-mediated cascade:FGFR2 22 6.33e-01 -0.058800 7.12e-01
Nephrin family interactions 21 6.51e-01 -0.057000 7.27e-01
Organic anion transporters 10 7.57e-01 -0.056600 8.14e-01
Regulation of insulin secretion 77 3.93e-01 -0.056300 4.94e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 5.71e-01 -0.056100 6.60e-01
Elastic fibre formation 41 5.35e-01 0.055900 6.26e-01
Cell surface interactions at the vascular wall 128 2.77e-01 0.055700 3.70e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 7.63e-01 0.055000 8.18e-01
Phenylalanine and tyrosine metabolism 10 7.67e-01 -0.054100 8.21e-01
Signal Transduction 2325 2.80e-05 -0.053300 1.48e-04
Syndecan interactions 19 6.89e-01 -0.053000 7.56e-01
RAC1 GTPase cycle 159 2.50e-01 -0.052900 3.44e-01
Reproduction 75 4.29e-01 -0.052900 5.24e-01
Opioid Signalling 88 3.93e-01 -0.052700 4.94e-01
Chylomicron assembly 10 7.74e-01 0.052500 8.25e-01
MET promotes cell motility 29 6.25e-01 -0.052400 7.07e-01
Phospholipase C-mediated cascade; FGFR4 14 7.36e-01 -0.052100 7.96e-01
Metabolism of steroid hormones 33 6.05e-01 0.052100 6.88e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 6.29e-01 -0.051800 7.11e-01
Trafficking of AMPA receptors 29 6.29e-01 -0.051800 7.11e-01
Inwardly rectifying K+ channels 35 5.97e-01 0.051700 6.80e-01
Signaling by Insulin receptor 76 4.39e-01 -0.051300 5.33e-01
Cell-Cell communication 111 3.56e-01 0.050800 4.54e-01
Signaling by Retinoic Acid 40 5.81e-01 -0.050400 6.69e-01
Incretin synthesis, secretion, and inactivation 22 6.89e-01 -0.049400 7.56e-01
Insulin receptor recycling 25 6.70e-01 0.049300 7.42e-01
Transferrin endocytosis and recycling 30 6.43e-01 0.048900 7.21e-01
MET activates RAS signaling 11 7.79e-01 -0.048700 8.29e-01
ABC transporters in lipid homeostasis 17 7.28e-01 0.048700 7.90e-01
PKA activation in glucagon signalling 17 7.44e-01 0.045700 8.02e-01
Regulation of TP53 Activity through Association with Co-factors 14 7.68e-01 -0.045400 8.22e-01
MAP2K and MAPK activation 33 6.52e-01 -0.045400 7.27e-01
Glycosaminoglycan metabolism 111 4.10e-01 -0.045300 5.10e-01
Diseases of glycosylation 129 3.77e-01 0.045100 4.77e-01
CRMPs in Sema3A signaling 15 7.63e-01 0.044900 8.18e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 28 6.86e-01 0.044200 7.54e-01
Serotonin Neurotransmitter Release Cycle 16 7.63e-01 0.043500 8.18e-01
Eicosanoid ligand-binding receptors 13 7.86e-01 0.043400 8.34e-01
Glutathione conjugation 37 6.51e-01 -0.043000 7.27e-01
Insulin processing 24 7.16e-01 -0.042900 7.80e-01
Glycerophospholipid biosynthesis 111 4.39e-01 -0.042600 5.33e-01
FGFR3 mutant receptor activation 11 8.08e-01 -0.042200 8.52e-01
Signaling by activated point mutants of FGFR3 11 8.08e-01 -0.042200 8.52e-01
Laminin interactions 23 7.26e-01 -0.042100 7.90e-01
VEGFR2 mediated cell proliferation 19 7.52e-01 -0.041900 8.10e-01
Biosynthesis of DHA-derived SPMs 17 7.67e-01 0.041500 8.21e-01
Signaling by ERBB2 KD Mutants 24 7.26e-01 0.041400 7.89e-01
Transport of small molecules 668 7.00e-02 0.041200 1.25e-01
O-linked glycosylation of mucins 56 5.94e-01 0.041100 6.79e-01
Nicotinate metabolism 25 7.22e-01 -0.041000 7.87e-01
Presynaptic function of Kainate receptors 21 7.45e-01 -0.040900 8.03e-01
L1CAM interactions 91 5.03e-01 0.040600 5.95e-01
Norepinephrine Neurotransmitter Release Cycle 16 7.79e-01 0.040600 8.28e-01
Glutamate Neurotransmitter Release Cycle 23 7.38e-01 0.040300 7.98e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 32 6.94e-01 -0.040100 7.60e-01
DAG and IP3 signaling 39 6.72e-01 0.039200 7.44e-01
Inositol phosphate metabolism 43 6.59e-01 0.038900 7.34e-01
Apoptotic cleavage of cellular proteins 34 6.97e-01 0.038600 7.62e-01
FCGR3A-mediated IL10 synthesis 37 6.89e-01 -0.038000 7.56e-01
Trafficking of GluR2-containing AMPA receptors 15 7.99e-01 -0.037900 8.45e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 7.59e-01 0.037800 8.15e-01
Neurodegenerative Diseases 22 7.59e-01 0.037800 8.15e-01
Lysine catabolism 10 8.36e-01 -0.037700 8.77e-01
Regulation of lipid metabolism by PPARalpha 115 4.92e-01 -0.037100 5.86e-01
Platelet calcium homeostasis 27 7.39e-01 0.037000 7.99e-01
PKA-mediated phosphorylation of CREB 19 7.82e-01 0.036700 8.31e-01
Activation of RAC1 11 8.33e-01 -0.036600 8.75e-01
Myogenesis 29 7.33e-01 -0.036500 7.94e-01
Netrin-1 signaling 49 6.58e-01 0.036500 7.34e-01
Signaling by FGFR4 in disease 11 8.36e-01 -0.036100 8.77e-01
Smooth Muscle Contraction 39 6.98e-01 -0.036000 7.62e-01
Signaling by Hippo 17 7.98e-01 0.035800 8.45e-01
Signaling by WNT in cancer 32 7.29e-01 -0.035400 7.91e-01
FGFR2b ligand binding and activation 10 8.47e-01 0.035300 8.86e-01
Heparan sulfate/heparin (HS-GAG) metabolism 49 6.73e-01 -0.034900 7.44e-01
HS-GAG degradation 18 8.02e-01 -0.034100 8.48e-01
Endogenous sterols 26 7.73e-01 0.032700 8.25e-01
Integrin signaling 27 7.74e-01 0.031900 8.25e-01
Signaling by ERBB4 55 6.84e-01 -0.031700 7.53e-01
Metabolism of steroids 143 5.13e-01 -0.031700 6.05e-01
Metabolism of lipids 669 1.64e-01 -0.031600 2.46e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 8.53e-01 0.030900 8.91e-01
G alpha (12/13) signalling events 68 6.60e-01 -0.030800 7.35e-01
Dopamine Neurotransmitter Release Cycle 20 8.12e-01 -0.030800 8.54e-01
DSCAM interactions 11 8.61e-01 -0.030500 8.97e-01
Glutathione synthesis and recycling 13 8.50e-01 0.030200 8.89e-01
Signaling by high-kinase activity BRAF mutants 32 7.69e-01 -0.030000 8.22e-01
PPARA activates gene expression 113 5.92e-01 -0.029200 6.78e-01
Defective Intrinsic Pathway for Apoptosis 25 8.08e-01 -0.028100 8.52e-01
PLC beta mediated events 47 7.40e-01 0.028000 7.99e-01
Phospholipase C-mediated cascade; FGFR3 12 8.69e-01 -0.027500 9.03e-01
Oncogenic MAPK signaling 75 6.82e-01 -0.027400 7.52e-01
Non-integrin membrane-ECM interactions 40 7.74e-01 0.026200 8.25e-01
Amyloid fiber formation 53 7.43e-01 -0.026000 8.02e-01
Activation of kainate receptors upon glutamate binding 29 8.11e-01 -0.025700 8.54e-01
Plasma lipoprotein assembly, remodeling, and clearance 72 7.08e-01 -0.025600 7.73e-01
Post-translational modification: synthesis of GPI-anchored proteins 86 6.83e-01 0.025400 7.53e-01
TRP channels 24 8.33e-01 0.024900 8.75e-01
Crosslinking of collagen fibrils 10 8.94e-01 -0.024400 9.20e-01
N-Glycan antennae elongation 15 8.73e-01 0.023800 9.06e-01
Cellular hexose transport 19 8.60e-01 0.023300 8.97e-01
G-protein mediated events 52 7.72e-01 0.023300 8.24e-01
Heme signaling 44 7.90e-01 -0.023200 8.37e-01
Acetylcholine regulates insulin secretion 10 9.00e-01 -0.023000 9.24e-01
LGI-ADAM interactions 14 8.85e-01 0.022400 9.16e-01
Glucagon signaling in metabolic regulation 33 8.25e-01 -0.022200 8.68e-01
Pre-NOTCH Expression and Processing 55 7.83e-01 0.021500 8.31e-01
SHC1 events in ERBB4 signaling 14 8.89e-01 0.021500 9.17e-01
FGFR1 ligand binding and activation 15 8.87e-01 -0.021300 9.17e-01
Processing of SMDT1 10 9.07e-01 -0.021300 9.29e-01
Fatty acid metabolism 160 6.49e-01 -0.020900 7.26e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 8.76e-01 0.020700 9.08e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 8.59e-01 -0.019400 8.96e-01
Activated point mutants of FGFR2 16 8.94e-01 -0.019200 9.20e-01
Signaling by BRAF and RAF1 fusions 59 8.02e-01 -0.018800 8.48e-01
Vitamin D (calciferol) metabolism 12 9.12e-01 -0.018400 9.33e-01
Physiological factors 12 9.13e-01 -0.018300 9.33e-01
Signaling by NTRK3 (TRKC) 16 9.00e-01 0.018200 9.24e-01
Synthesis of PIPs at the plasma membrane 48 8.32e-01 -0.017600 8.75e-01
RET signaling 41 8.46e-01 0.017500 8.86e-01
MECP2 regulates neuronal receptors and channels 17 9.03e-01 0.017100 9.26e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 39 8.56e-01 0.016800 8.93e-01
Ephrin signaling 17 9.07e-01 0.016300 9.29e-01
Amino acid transport across the plasma membrane 30 8.78e-01 -0.016200 9.10e-01
Integration of energy metabolism 106 7.78e-01 -0.015900 8.28e-01
Activation of G protein gated Potassium channels 29 8.89e-01 0.015000 9.17e-01
G protein gated Potassium channels 29 8.89e-01 0.015000 9.17e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 8.89e-01 0.015000 9.17e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 9.26e-01 0.014900 9.42e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 8.70e-01 -0.014800 9.03e-01
Signaling by RAS mutants 41 8.70e-01 -0.014800 9.03e-01
Signaling by moderate kinase activity BRAF mutants 41 8.70e-01 -0.014800 9.03e-01
Signaling downstream of RAS mutants 41 8.70e-01 -0.014800 9.03e-01
Leishmania infection 244 6.90e-01 0.014800 7.57e-01
Constitutive Signaling by EGFRvIII 15 9.25e-01 -0.014000 9.42e-01
Signaling by EGFRvIII in Cancer 15 9.25e-01 -0.014000 9.42e-01
Interleukin-20 family signaling 22 9.12e-01 0.013600 9.33e-01
Pre-NOTCH Processing in Golgi 18 9.22e-01 -0.013300 9.41e-01
Pre-NOTCH Transcription and Translation 40 8.86e-01 0.013100 9.17e-01
Nuclear signaling by ERBB4 30 9.02e-01 0.012900 9.26e-01
Activation of SMO 17 9.27e-01 0.012800 9.43e-01
Platelet activation, signaling and aggregation 244 7.30e-01 -0.012800 7.91e-01
Constitutive Signaling by Aberrant PI3K in Cancer 76 8.51e-01 -0.012500 8.89e-01
Synaptic adhesion-like molecules 19 9.25e-01 0.012500 9.42e-01
Nicotinamide salvaging 16 9.35e-01 0.011900 9.49e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 9.37e-01 0.011700 9.49e-01
Phospholipase C-mediated cascade: FGFR1 16 9.36e-01 -0.011500 9.49e-01
NRAGE signals death through JNK 47 8.97e-01 0.010900 9.23e-01
Developmental Biology 991 5.65e-01 0.010800 6.54e-01
Signal transduction by L1 20 9.36e-01 -0.010300 9.49e-01
Phospholipase C-mediated cascade; FGFR2 17 9.42e-01 -0.010100 9.52e-01
Synthesis of very long-chain fatty acyl-CoAs 19 9.42e-01 -0.009720 9.52e-01
CS/DS degradation 12 9.54e-01 -0.009590 9.60e-01
Signaling by RAF1 mutants 37 9.23e-01 0.009190 9.42e-01
Signaling by ERBB2 in Cancer 25 9.39e-01 0.008860 9.50e-01
MET activates PTK2 signaling 18 9.49e-01 -0.008630 9.57e-01
HS-GAG biosynthesis 28 9.40e-01 0.008240 9.50e-01
DAP12 interactions 40 9.31e-01 -0.007860 9.46e-01
Depolymerisation of the Nuclear Lamina 12 9.66e-01 -0.007160 9.70e-01
Hyaluronan metabolism 15 9.62e-01 -0.007070 9.67e-01
Hemostasis 547 7.83e-01 -0.006890 8.31e-01
Aquaporin-mediated transport 51 9.35e-01 0.006610 9.49e-01
Platelet homeostasis 85 9.21e-01 0.006260 9.40e-01
Role of phospholipids in phagocytosis 23 9.59e-01 0.006220 9.65e-01
Transcriptional Regulation by MECP2 55 9.43e-01 0.005590 9.52e-01
FGFRL1 modulation of FGFR1 signaling 13 9.72e-01 -0.005530 9.76e-01
Diseases of metabolism 226 8.90e-01 -0.005350 9.17e-01
Ca2+ pathway 58 9.46e-01 -0.005110 9.54e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 9.53e-01 -0.005050 9.60e-01
Signaling by ERBB2 ECD mutants 15 9.83e-01 -0.003170 9.85e-01
Plasma lipoprotein assembly 19 9.81e-01 -0.003130 9.84e-01
Biosynthesis of specialized proresolving mediators (SPMs) 19 9.83e-01 -0.002750 9.85e-01
SLC transporter disorders 91 9.83e-01 -0.001300 9.85e-01
Dissolution of Fibrin Clot 13 9.94e-01 0.001160 9.95e-01
Prolactin receptor signaling 15 9.95e-01 0.000953 9.95e-01


Detailed Gene set reports



SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1162
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 11
pANOVA 0.000682
s.dist -0.591
p.adjustANOVA 0.00239



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -14270
SNRPF -14115
SNRPG -14046
SNRPD3 -13147
NCBP2 -12591
ZNF473 -11718
SLBP -11308
SNRPB -11084
SNRPE -11073
LSM10 -4980
LSM11 -2573

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -14270
SNRPF -14115
SNRPG -14046
SNRPD3 -13147
NCBP2 -12591
ZNF473 -11718
SLBP -11308
SNRPB -11084
SNRPE -11073
LSM10 -4980
LSM11 -2573


SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs
1163
set SLBP independent Processing of Histone Pre-mRNAs
setSize 10
pANOVA 0.00128
s.dist -0.588
p.adjustANOVA 0.0041



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -14270
SNRPF -14115
SNRPG -14046
SNRPD3 -13147
NCBP2 -12591
ZNF473 -11718
SNRPB -11084
SNRPE -11073
LSM10 -4980
LSM11 -2573

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -14270
SNRPF -14115
SNRPG -14046
SNRPD3 -13147
NCBP2 -12591
ZNF473 -11718
SNRPB -11084
SNRPE -11073
LSM10 -4980
LSM11 -2573


Resolution of D-Loop Structures

Resolution of D-Loop Structures
1123
set Resolution of D-Loop Structures
setSize 26
pANOVA 7.45e-07
s.dist -0.561
p.adjustANOVA 7.3e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
EME2 -14517
RBBP8 -14455
MUS81 -14431
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
GEN1 -13262
RTEL1 -11274
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
EME1 -7639

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
EME2 -14517
RBBP8 -14455
MUS81 -14431
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
GEN1 -13262
RTEL1 -11274
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
EME1 -7639
XRCC3 -6672
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Pexophagy

Pexophagy
898
set Pexophagy
setSize 11
pANOVA 0.00134
s.dist -0.558
p.adjustANOVA 0.00423



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATM -15058
UBC -15008
SQSTM1 -14793
RPS27A -13898
UBB -13480
NBR1 -12340
MAP1LC3B -9714
PEX5 -6212
UBA52 -6091
USP30 -5845
EPAS1 -4827

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATM -15058
UBC -15008
SQSTM1 -14793
RPS27A -13898
UBB -13480
NBR1 -12340
MAP1LC3B -9714
PEX5 -6212
UBA52 -6091
USP30 -5845
EPAS1 -4827


Resolution of D-loop Structures through Holliday Junction Intermediates

Resolution of D-loop Structures through Holliday Junction Intermediates
1124
set Resolution of D-loop Structures through Holliday Junction Intermediates
setSize 25
pANOVA 1.35e-06
s.dist -0.558
p.adjustANOVA 1.17e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
EME2 -14517
RBBP8 -14455
MUS81 -14431
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
GEN1 -13262
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
EME1 -7639
XRCC3 -6672

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
EME2 -14517
RBBP8 -14455
MUS81 -14431
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
GEN1 -13262
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
EME1 -7639
XRCC3 -6672
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Activation of the phototransduction cascade

Activation of the phototransduction cascade
56
set Activation of the phototransduction cascade
setSize 11
pANOVA 0.00141
s.dist 0.556
p.adjustANOVA 0.00442



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC24A1 4916
GNGT1 3711
PDE6A 3077
CNGA1 2939
PDE6G 2233
SAG 1064
PDE6B 869
CNGB1 -1353
RHO -1573
GNB1 -4312
GNAT1 -5758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC24A1 4916
GNGT1 3711
PDE6A 3077
CNGA1 2939
PDE6G 2233
SAG 1064
PDE6B 869
CNGB1 -1353
RHO -1573
GNB1 -4312
GNAT1 -5758


Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
395
set Expression and translocation of olfactory receptors
setSize 331
pANOVA 3.74e-65
s.dist 0.543
p.adjustANOVA 1.89e-62



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR10H1 4932
OR2L13 4909
OR6B3 4905
OR1G1 4895
OR5V1 4862
OR10J5 4845
OR12D2 4812
OR2AG2 4806
OR6A2 4800
OR4X1 4733
OR10A5 4701
OR10C1 4675
OR6V1 4640
OR8D1 4612
OR1S1 4606
OR4M2 4555
OR5H2 4542
OR2M5 4533
OR2M3 4531
OR10P1 4520

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR10H1 4932.0
OR2L13 4909.0
OR6B3 4905.0
OR1G1 4895.0
OR5V1 4862.0
OR10J5 4845.0
OR12D2 4812.0
OR2AG2 4806.0
OR6A2 4800.0
OR4X1 4733.0
OR10A5 4701.0
OR10C1 4675.0
OR6V1 4640.0
OR8D1 4612.0
OR1S1 4606.0
OR4M2 4555.0
OR5H2 4542.0
OR2M5 4533.0
OR2M3 4531.0
OR10P1 4520.0
OR2D3 4428.0
OR10A3 4427.0
OR5I1 4422.0
OR10J3 4408.0
OR2H1 4394.0
OR10H3 4381.0
OR1K1 4370.0
OR52J3 4367.0
OR51G1 4364.0
OR52H1 4344.0
OR8H2 4323.0
OR2B11 4317.0
OR51Q1 4293.0
OR51S1 4292.0
OR1A2 4278.0
OR4F5 4263.0
OR5D18 4248.0
OR6T1 4222.0
OR6Y1 4198.0
OR8B8 4183.0
OR2C1 4151.0
OR2AT4 4150.0
OR4D6 4143.0
OR2T8 4140.0
OR1Q1 4138.0
OR52R1 4123.0
OR6S1 4115.0
OR6C3 4111.0
OR6F1 4102.0
OR9Q2 4096.0
OR8H3 4090.0
OR8U8 4068.0
OR51D1 4047.0
OR8J3 4016.0
OR9I1 4013.0
OR14I1 4009.0
OR52I2 3983.0
OR8G5 3980.0
OR6K2 3958.0
OR51E1 3957.0
OR4K17 3950.0
OR8K3 3927.0
OR8G1 3881.0
OR52A1 3872.0
OR52E2 3799.0
OR11A1 3776.0
OR51V1 3751.0
OR2G3 3747.0
OR10W1 3737.0
OR10T2 3662.0
OR14A16 3652.0
OR51I2 3644.0
OR9Q1 3639.0
OR5AP2 3635.0
OR1M1 3618.0
OR51A7 3587.0
OR10K2 3571.0
OR51B5 3561.0
OR7D2 3529.0
OR9G4 3496.0
OR8B2 3460.0
OR51T1 3441.0
OR2T6 3389.0
OR6N1 3280.0
OR2T4 3261.0
OR2T1 3235.0
OR5P3 3175.0
OR5A2 3039.0
OR6X1 2703.0
OR2T33 2664.0
OR6P1 2564.0
OR8B12 2519.0
OR51E2 2388.0
OR2W5 2386.0
OR10J1 2364.0
OR1C1 2358.0
OR10V1 2320.0
OR7D4 2192.0
OR11L1 2020.0
OR5B21 1851.0
OR6K3 1526.0
OR2AG1 1101.0
OR4D1 972.0
OR13J1 910.0
OR7C2 713.0
OR1B1 0.5
OR2B3 0.5
OR5M10 0.5
OR4C15 0.5
OR2A4 0.5
OR5L1 0.5
OR10AG1 0.5
OR4Q3 0.5
RTP2 0.5
OR2J2 0.5
OR4K1 0.5
OR5D13 0.5
OR5A1 0.5
OR6C6 0.5
OR6B1 0.5
OR1J4 0.5
OR6C65 0.5
OR52D1 0.5
OR2T3 0.5
OR5M8 0.5
OR5AU1 0.5
OR10X1 0.5
OR5AC2 0.5
OR1N1 0.5
OR5AN1 0.5
OR11H6 0.5
OR10H5 0.5
OR7G3 0.5
OR4K15 0.5
OR5H1 0.5
OR51L1 0.5
OR4C3 0.5
OR5D14 0.5
OR4C13 0.5
OR2T12 0.5
OR5H15 0.5
OR2K2 0.5
OR5M9 0.5
OR52L1 0.5
OR5R1 0.5
OR52I1 0.5
OR4D9 0.5
OR10K1 0.5
OR2W1 0.5
OR52N2 0.5
OR1J1 0.5
OR8K1 0.5
OR7A10 0.5
OR9G9 0.5
OR9G1 0.5
OR52B2 0.5
OR56B4 0.5
OR13G1 0.5
OR5L2 0.5
OR5K4 0.5
OR5M11 0.5
OR10H4 0.5
OR2Z1 0.5
OR2T27 0.5
OR2W3 0.5
OR8D4 0.5
OR5D16 0.5
OR7E24 0.5
OR9A2 0.5
OR2L2 0.5
OR52K1 0.5
OR4L1 0.5
OR2D2 0.5
OR1J2 0.5
OR2M2 0.5
OR52A5 0.5
OR9A4 0.5
OR52K2 0.5
OR8J1 0.5
OR4C6 0.5
OR2Y1 0.5
OR6Q1 0.5
OR1E1 0.5
OR5AS1 0.5
OR4S1 0.5
OR10S1 0.5
OR6C1 0.5
OR4K14 0.5
OR10G9 0.5
OR6C70 0.5
OR51M1 0.5
OR10A2 0.5
OR51B4 0.5
OR13F1 0.5
OR11G2 0.5
OR10A4 0.5
OR2A2 0.5
OR8U1 0.5
OR52N5 0.5
OR10Z1 0.5
OR51B6 0.5
OR52M1 0.5
OR5AR1 0.5
OR51F1 0.5
OR6C74 0.5
OR51F2 0.5
OR6K6 0.5
OR13C4 0.5
OR8B3 0.5
OR3A1 0.5
OR9K2 0.5
OR10G8 0.5
OR2L8 0.5
OR4A15 0.5
OR56A1 0.5
OR2G6 0.5
OR10A7 0.5
OR4M1 0.5
OR5T2 0.5
OR4K13 0.5
OR6C76 0.5
OR1D2 0.5
OR4D10 0.5
OR2F2 0.5
OR5H6 0.5
OR2A12 0.5
OR14C36 0.5
OR8H1 0.5
OR2A25 0.5
OR8A1 0.5
OR2AK2 0.5
OR56B1 0.5
OR7G1 0.5
OR13C3 0.5
OR8G2 0.5
OR5B2 0.5
OR2A14 0.5
OR2A7 0.5
OR5T1 0.5
OR56A3 0.5
OR5K2 0.5
OR2T29 0.5
OR5B3 0.5
OR5M1 0.5
OR51G2 0.5
OR2T34 0.5
OR2B6 0.5
OR4C45 0.5
OR1L6 0.5
OR2S2 0.5
OR52E6 0.5
OR5AK2 0.5
OR5C1 0.5
OR8K5 0.5
OR4N2 0.5
OR2M7 0.5
OR1D5 0.5
OR1D4 0.5
OR4A5 0.5
OR51I1 0.5
OR56A4 0.5
OR51A2 0.5
OR4A16 0.5
OR5B17 0.5
OR4D11 0.5
OR6C4 0.5
OR4S2 0.5
OR4A47 0.5
OR4C46 0.5
OR8I2 0.5
OR2B2 0.5
EBF1 -700.0
OR5P2 -999.0
OR13A1 -1082.0
OR4F6 -1237.0
OR2H2 -1531.0
OR1F1 -1798.0
OR51B2 -2021.0
OR1L3 -2201.0
OR2J3 -2206.0
OR6B2 -2216.0
OR2A5 -2250.0
OR52B6 -2607.0
OR10G7 -2680.0
OR5B12 -2794.0
OR2V2 -2846.0
OR52W1 -2902.0
OR6M1 -2918.0
RTP1 -3072.0
OR12D3 -3202.0
OR8S1 -3323.0
OR2AE1 -3437.0
OR10G4 -3452.0
OR4C12 -3549.0
OR56A5 -3614.0
OR7C1 -3895.0
OR10G2 -3903.0
OR2C3 -3918.0
OR2F1 -4054.0
OR52N1 -4464.0
OR1I1 -4473.0
OR2L3 -4663.0
OR4D2 -4669.0
OR10AD1 -4695.0
OR4F15 -5000.0
OR3A2 -5062.0
REEP1 -5183.0
OR4N5 -5306.0
OR2G2 -5754.0
OR10G3 -5819.0
OR4C16 -5890.0
OR11H4 -5899.0
OR7A17 -6094.0
OR4E2 -6196.0
OR7G2 -6548.0
OR1A1 -6749.0
OR4D5 -6772.0
OR6N2 -6820.0
OR52E8 -6863.0
OR4K2 -7023.0
OR8B4 -7097.0
OR10H2 -7135.0
OR2T5 -7305.0
OR3A3 -7648.0
OR7A5 -7869.0
OR14J1 -7946.0
OR1S2 -8174.0
OR1E2 -8996.0
OR10Q1 -10260.0
LHX2 -12273.0
LDB1 -12479.0


Creation of C4 and C2 activators

Creation of C4 and C2 activators
238
set Creation of C4 and C2 activators
setSize 14
pANOVA 0.00044
s.dist 0.542
p.adjustANOVA 0.00162



Top enriched genes

Top 20 genes
GeneID Gene Rank
COLEC10 4746.0
CRP 4472.0
C1QA 2928.0
MASP2 2652.0
FCN3 1971.0
C1QB 1366.0
FCN1 1262.0
MASP1 1108.0
FCN2 0.5
COLEC11 -1811.0
C1S -1993.0
MBL2 -2140.0
C1R -4157.0
C1QC -4914.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COLEC10 4746.0
CRP 4472.0
C1QA 2928.0
MASP2 2652.0
FCN3 1971.0
C1QB 1366.0
FCN1 1262.0
MASP1 1108.0
FCN2 0.5
COLEC11 -1811.0
C1S -1993.0
MBL2 -2140.0
C1R -4157.0
C1QC -4914.0


Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function
284
set Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function
setSize 20
pANOVA 2.72e-05
s.dist -0.542
p.adjustANOVA 0.000144



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function
285
set Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function
setSize 20
pANOVA 2.72e-05
s.dist -0.542
p.adjustANOVA 0.000144



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
286
set Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
setSize 20
pANOVA 2.72e-05
s.dist -0.542
p.adjustANOVA 0.000144



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
287
set Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
setSize 20
pANOVA 2.72e-05
s.dist -0.542
p.adjustANOVA 0.000144



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Impaired BRCA2 binding to PALB2

Impaired BRCA2 binding to PALB2
580
set Impaired BRCA2 binding to PALB2
setSize 20
pANOVA 2.72e-05
s.dist -0.542
p.adjustANOVA 0.000144



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
224
set Condensation of Prometaphase Chromosomes
setSize 11
pANOVA 0.00194
s.dist -0.539
p.adjustANOVA 0.00579



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B -15030.0
SMC4 -14749.0
NCAPH -13862.0
NCAPG -13492.0
CCNB2 -12466.0
NCAPD2 -11750.0
SMC2 -10933.0
CDK1 -9233.5
CCNB1 -7956.0
CSNK2A2 -7226.0
CSNK2A1 1520.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B -15030.0
SMC4 -14749.0
NCAPH -13862.0
NCAPG -13492.0
CCNB2 -12466.0
NCAPD2 -11750.0
SMC2 -10933.0
CDK1 -9233.5
CCNB1 -7956.0
CSNK2A2 -7226.0
CSNK2A1 1520.0


Olfactory Signaling Pathway

Olfactory Signaling Pathway
841
set Olfactory Signaling Pathway
setSize 338
pANOVA 2.95e-65
s.dist 0.538
p.adjustANOVA 1.89e-62



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR10H1 4932
OR2L13 4909
OR6B3 4905
OR1G1 4895
OR5V1 4862
OR10J5 4845
OR12D2 4812
OR2AG2 4806
OR6A2 4800
OR4X1 4733
OR10A5 4701
OR10C1 4675
OR6V1 4640
OR8D1 4612
OR1S1 4606
OR4M2 4555
OR5H2 4542
OR2M5 4533
OR2M3 4531
OR10P1 4520

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR10H1 4932.0
OR2L13 4909.0
OR6B3 4905.0
OR1G1 4895.0
OR5V1 4862.0
OR10J5 4845.0
OR12D2 4812.0
OR2AG2 4806.0
OR6A2 4800.0
OR4X1 4733.0
OR10A5 4701.0
OR10C1 4675.0
OR6V1 4640.0
OR8D1 4612.0
OR1S1 4606.0
OR4M2 4555.0
OR5H2 4542.0
OR2M5 4533.0
OR2M3 4531.0
OR10P1 4520.0
OR2D3 4428.0
OR10A3 4427.0
OR5I1 4422.0
OR10J3 4408.0
OR2H1 4394.0
OR10H3 4381.0
OR1K1 4370.0
OR52J3 4367.0
OR51G1 4364.0
OR52H1 4344.0
OR8H2 4323.0
OR2B11 4317.0
OR51Q1 4293.0
OR51S1 4292.0
OR1A2 4278.0
OR4F5 4263.0
OR5D18 4248.0
OR6T1 4222.0
OR6Y1 4198.0
OR8B8 4183.0
OR2C1 4151.0
OR2AT4 4150.0
OR4D6 4143.0
OR2T8 4140.0
OR1Q1 4138.0
OR52R1 4123.0
OR6S1 4115.0
OR6C3 4111.0
OR6F1 4102.0
OR9Q2 4096.0
OR8H3 4090.0
OR8U8 4068.0
OR51D1 4047.0
OR8J3 4016.0
OR9I1 4013.0
OR14I1 4009.0
OR52I2 3983.0
OR8G5 3980.0
OR6K2 3958.0
OR51E1 3957.0
OR4K17 3950.0
OR8K3 3927.0
OR8G1 3881.0
OR52A1 3872.0
OR52E2 3799.0
OR11A1 3776.0
OR51V1 3751.0
OR2G3 3747.0
OR10W1 3737.0
OR10T2 3662.0
OR14A16 3652.0
OR51I2 3644.0
OR9Q1 3639.0
OR5AP2 3635.0
OR1M1 3618.0
OR51A7 3587.0
OR10K2 3571.0
OR51B5 3561.0
OR7D2 3529.0
OR9G4 3496.0
OR8B2 3460.0
OR51T1 3441.0
OR2T6 3389.0
OR6N1 3280.0
OR2T4 3261.0
OR2T1 3235.0
OR5P3 3175.0
OR5A2 3039.0
OR6X1 2703.0
OR2T33 2664.0
OR6P1 2564.0
OR8B12 2519.0
OR51E2 2388.0
OR2W5 2386.0
OR10J1 2364.0
OR1C1 2358.0
OR10V1 2320.0
OR7D4 2192.0
CNGA4 2133.0
OR11L1 2020.0
OR5B21 1851.0
OR6K3 1526.0
ANO2 1135.0
OR2AG1 1101.0
OR4D1 972.0
OR13J1 910.0
OR7C2 713.0
OR1B1 0.5
OR2B3 0.5
OR5M10 0.5
OR4C15 0.5
OR2A4 0.5
OR5L1 0.5
OR10AG1 0.5
OR4Q3 0.5
RTP2 0.5
OR2J2 0.5
OR4K1 0.5
OR5D13 0.5
OR5A1 0.5
OR6C6 0.5
OR6B1 0.5
OR1J4 0.5
OR6C65 0.5
OR52D1 0.5
OR2T3 0.5
OR5M8 0.5
OR5AU1 0.5
OR10X1 0.5
OR5AC2 0.5
OR1N1 0.5
OR5AN1 0.5
OR11H6 0.5
OR10H5 0.5
OR7G3 0.5
OR4K15 0.5
OR5H1 0.5
OR51L1 0.5
OR4C3 0.5
OR5D14 0.5
OR4C13 0.5
OR2T12 0.5
OR5H15 0.5
OR2K2 0.5
OR5M9 0.5
OR52L1 0.5
OR5R1 0.5
OR52I1 0.5
OR4D9 0.5
OR10K1 0.5
OR2W1 0.5
OR52N2 0.5
OR1J1 0.5
OR8K1 0.5
OR7A10 0.5
OR9G9 0.5
OR9G1 0.5
OR52B2 0.5
OR56B4 0.5
OR13G1 0.5
OR5L2 0.5
OR5K4 0.5
OR5M11 0.5
OR10H4 0.5
OR2Z1 0.5
OR2T27 0.5
OR2W3 0.5
OR8D4 0.5
OR5D16 0.5
OR7E24 0.5
OR9A2 0.5
OR2L2 0.5
OR52K1 0.5
OR4L1 0.5
OR2D2 0.5
OR1J2 0.5
OR2M2 0.5
OR52A5 0.5
OR9A4 0.5
OR52K2 0.5
OR8J1 0.5
OR4C6 0.5
OR2Y1 0.5
OR6Q1 0.5
OR1E1 0.5
OR5AS1 0.5
OR4S1 0.5
OR10S1 0.5
OR6C1 0.5
OR4K14 0.5
OR10G9 0.5
OR6C70 0.5
OR51M1 0.5
OR10A2 0.5
OR51B4 0.5
OR13F1 0.5
OR11G2 0.5
OR10A4 0.5
OR2A2 0.5
OR8U1 0.5
OR52N5 0.5
OR10Z1 0.5
OR51B6 0.5
OR52M1 0.5
OR5AR1 0.5
OR51F1 0.5
OR6C74 0.5
OR51F2 0.5
OR6K6 0.5
OR13C4 0.5
OR8B3 0.5
OR3A1 0.5
OR9K2 0.5
OR10G8 0.5
OR2L8 0.5
OR4A15 0.5
OR56A1 0.5
OR2G6 0.5
OR10A7 0.5
OR4M1 0.5
OR5T2 0.5
OR4K13 0.5
OR6C76 0.5
OR1D2 0.5
OR4D10 0.5
OR2F2 0.5
OR5H6 0.5
OR2A12 0.5
OR14C36 0.5
OR8H1 0.5
OR2A25 0.5
OR8A1 0.5
OR2AK2 0.5
OR56B1 0.5
OR7G1 0.5
OR13C3 0.5
OR8G2 0.5
OR5B2 0.5
OR2A14 0.5
OR2A7 0.5
OR5T1 0.5
OR56A3 0.5
OR5K2 0.5
OR2T29 0.5
OR5B3 0.5
OR5M1 0.5
OR51G2 0.5
OR2T34 0.5
OR2B6 0.5
OR4C45 0.5
OR1L6 0.5
OR2S2 0.5
OR52E6 0.5
OR5AK2 0.5
OR5C1 0.5
OR8K5 0.5
OR4N2 0.5
OR2M7 0.5
OR1D5 0.5
OR1D4 0.5
OR4A5 0.5
OR51I1 0.5
OR56A4 0.5
OR51A2 0.5
OR4A16 0.5
OR5B17 0.5
OR4D11 0.5
OR6C4 0.5
OR4S2 0.5
OR4A47 0.5
OR4C46 0.5
OR8I2 0.5
OR2B2 0.5
EBF1 -700.0
OR5P2 -999.0
OR13A1 -1082.0
OR4F6 -1237.0
CNGB1 -1353.0
ADCY3 -1489.0
OR2H2 -1531.0
OR1F1 -1798.0
OR51B2 -2021.0
OR1L3 -2201.0
OR2J3 -2206.0
OR6B2 -2216.0
OR2A5 -2250.0
OR52B6 -2607.0
OR10G7 -2680.0
OR5B12 -2794.0
OR2V2 -2846.0
OR52W1 -2902.0
OR6M1 -2918.0
RTP1 -3072.0
OR12D3 -3202.0
OR8S1 -3323.0
OR2AE1 -3437.0
OR10G4 -3452.0
OR4C12 -3549.0
OR56A5 -3614.0
GNG13 -3855.0
OR7C1 -3895.0
OR10G2 -3903.0
OR2C3 -3918.0
OR2F1 -4054.0
GNB1 -4312.0
OR52N1 -4464.0
OR1I1 -4473.0
OR2L3 -4663.0
OR4D2 -4669.0
OR10AD1 -4695.0
OR4F15 -5000.0
OR3A2 -5062.0
REEP1 -5183.0
OR4N5 -5306.0
OR2G2 -5754.0
OR10G3 -5819.0
OR4C16 -5890.0
OR11H4 -5899.0
OR7A17 -6094.0
OR4E2 -6196.0
OR7G2 -6548.0
OR1A1 -6749.0
OR4D5 -6772.0
OR6N2 -6820.0
OR52E8 -6863.0
OR4K2 -7023.0
OR8B4 -7097.0
OR10H2 -7135.0
OR2T5 -7305.0
OR3A3 -7648.0
GNAL -7804.0
OR7A5 -7869.0
OR14J1 -7946.0
OR1S2 -8174.0
OR1E2 -8996.0
OR10Q1 -10260.0
LHX2 -12273.0
LDB1 -12479.0


SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy
1148
set SARS-CoV-2 modulates autophagy
setSize 11
pANOVA 0.00233
s.dist -0.53
p.adjustANOVA 0.0068



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS39 -12190
VPS33A -12043
VPS41 -11940
UVRAG -11132
VPS16 -10759
TUFM -10415
VPS18 -10358
VPS11 -9763
MAP1LC3B -9714
VPS45 -8065
VPS33B -7751

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS39 -12190
VPS33A -12043
VPS41 -11940
UVRAG -11132
VPS16 -10759
TUFM -10415
VPS18 -10358
VPS11 -9763
MAP1LC3B -9714
VPS45 -8065
VPS33B -7751


Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
1125
set Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
setSize 22
pANOVA 1.79e-05
s.dist -0.528
p.adjustANOVA 0.000102



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RTEL1 -11274
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
XRCC3 -6672
RAD50 -5984
NBN -3216
PALB2 -1609

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
WRN -14575
RBBP8 -14455
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RTEL1 -11274
RAD51AP1 -10093
XRCC2 -8989
BARD1 -8927
XRCC3 -6672
RAD50 -5984
NBN -3216
PALB2 -1609
BRIP1 1804
RAD51C 2024


Fatty acids

Fatty acids
432
set Fatty acids
setSize 15
pANOVA 0.000456
s.dist 0.523
p.adjustANOVA 0.00166



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP4F3 4869
CYP2D6 4583
CYP4B1 4511
CYP2J2 3782
CYP4F22 2702
CYP2A13 2436
CYP4F8 1603
CYP2F1 709
CYP2A7 -782
CYP2B6 -1577
CYP4A22 -1714
CYP4F2 -2100
CYP4F11 -2760
CYP4A11 -6249
CYP4F12 -7108

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F3 4869
CYP2D6 4583
CYP4B1 4511
CYP2J2 3782
CYP4F22 2702
CYP2A13 2436
CYP4F8 1603
CYP2F1 709
CYP2A7 -782
CYP2B6 -1577
CYP4A22 -1714
CYP4F2 -2100
CYP4F11 -2760
CYP4A11 -6249
CYP4F12 -7108


RNA Polymerase II Transcription Termination

RNA Polymerase II Transcription Termination
1026
set RNA Polymerase II Transcription Termination
setSize 50
pANOVA 3.09e-10
s.dist -0.514
p.adjustANOVA 6.9e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLP1 -15018
RBM8A -15015
SYMPK -14876
CDC40 -14458
CSTF2T -14444
NCBP1 -14270
SNRPF -14115
SNRPG -14046
NUDT21 -13923
EIF4A3 -13510
CPSF2 -13226
CASC3 -13222
SNRPD3 -13147
MAGOH -13115
PCF11 -12858
THOC5 -12785
CSTF1 -12771
NCBP2 -12591
DHX38 -12301
RNPS1 -12222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLP1 -15018
RBM8A -15015
SYMPK -14876
CDC40 -14458
CSTF2T -14444
NCBP1 -14270
SNRPF -14115
SNRPG -14046
NUDT21 -13923
EIF4A3 -13510
CPSF2 -13226
CASC3 -13222
SNRPD3 -13147
MAGOH -13115
PCF11 -12858
THOC5 -12785
CSTF1 -12771
NCBP2 -12591
DHX38 -12301
RNPS1 -12222
ZC3H11A -11878
THOC6 -11814
FYTTD1 -11720
ZNF473 -11718
SLBP -11308
SLU7 -11159
U2AF1 -11111
SNRPB -11084
SNRPE -11073
MAGOHB -11071
POLDIP3 -11069
THOC1 -11000
THOC7 -10468
SARNP -10217
U2AF1L4 -8756
FIP1L1 -8308
PAPOLA -7468
CSTF3 -7076
CPSF3 -6879
PABPN1 -6875
CPSF6 -6012
CPSF7 -5895
WDR33 -5261
LSM10 -4980
CPSF4 -3669
U2AF2 -3247
CPSF1 -3188
THOC3 -2826
LSM11 -2573
SRRM1 1242


Impaired BRCA2 binding to RAD51

Impaired BRCA2 binding to RAD51
581
set Impaired BRCA2 binding to RAD51
setSize 31
pANOVA 8.02e-07
s.dist -0.512
p.adjustANOVA 7.77e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
ATR -14922
WRN -14575
RBBP8 -14455
RFC3 -14359
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD1 -13157
RFC2 -12876
RFC5 -12234
RAD17 -11011
RAD9B -9266
BARD1 -8927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 -15079
ATM -15058
RMI1 -14994
KAT5 -14982
DNA2 -14973
ATR -14922
WRN -14575
RBBP8 -14455
RFC3 -14359
EXO1 -14250
BRCA2 -14217
BLM -14169
RAD51 -14122
TOP3A -13966
RAD1 -13157
RFC2 -12876
RFC5 -12234
RAD17 -11011
RAD9B -9266
BARD1 -8927
RPA3 -8846
TOPBP1 -8273
HUS1 -8101
ATRIP -7558
RAD50 -5984
RAD9A -3226
NBN -3216
RPA2 -942
RFC4 -716
RPA1 800
BRIP1 1804


mRNA 3’-end processing

mRNA 3’-end processing
1493
set mRNA 3’-end processing
setSize 41
pANOVA 1.71e-08
s.dist -0.509
p.adjustANOVA 2.55e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLP1 -15018
RBM8A -15015
SYMPK -14876
CDC40 -14458
CSTF2T -14444
NCBP1 -14270
NUDT21 -13923
EIF4A3 -13510
CPSF2 -13226
CASC3 -13222
MAGOH -13115
PCF11 -12858
THOC5 -12785
CSTF1 -12771
NCBP2 -12591
DHX38 -12301
RNPS1 -12222
ZC3H11A -11878
THOC6 -11814
FYTTD1 -11720

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLP1 -15018
RBM8A -15015
SYMPK -14876
CDC40 -14458
CSTF2T -14444
NCBP1 -14270
NUDT21 -13923
EIF4A3 -13510
CPSF2 -13226
CASC3 -13222
MAGOH -13115
PCF11 -12858
THOC5 -12785
CSTF1 -12771
NCBP2 -12591
DHX38 -12301
RNPS1 -12222
ZC3H11A -11878
THOC6 -11814
FYTTD1 -11720
SLU7 -11159
U2AF1 -11111
MAGOHB -11071
POLDIP3 -11069
THOC1 -11000
THOC7 -10468
SARNP -10217
U2AF1L4 -8756
FIP1L1 -8308
PAPOLA -7468
CSTF3 -7076
CPSF3 -6879
PABPN1 -6875
CPSF6 -6012
CPSF7 -5895
WDR33 -5261
CPSF4 -3669
U2AF2 -3247
CPSF1 -3188
THOC3 -2826
SRRM1 1242


ALK mutants bind TKIs

ALK mutants bind TKIs
9
set ALK mutants bind TKIs
setSize 12
pANOVA 0.00248
s.dist -0.504
p.adjustANOVA 0.00711



Top enriched genes

Top 20 genes
GeneID Gene Rank
BIRC6 -14213
PRKAR1A -14148
STRN -13491
PPM1B -12946
HIP1 -12430
CLTC -12081
BCL11A -10748
EIF2AK3 -9548
NPM1 -8451
ALK -4945
EML4 -4408
FN1 -4000

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BIRC6 -14213
PRKAR1A -14148
STRN -13491
PPM1B -12946
HIP1 -12430
CLTC -12081
BCL11A -10748
EIF2AK3 -9548
NPM1 -8451
ALK -4945
EML4 -4408
FN1 -4000


Reversible hydration of carbon dioxide

Reversible hydration of carbon dioxide
1139
set Reversible hydration of carbon dioxide
setSize 11
pANOVA 0.00379
s.dist 0.504
p.adjustANOVA 0.0103



Top enriched genes

Top 20 genes
GeneID Gene Rank
CA1 4795.0
CA12 3566.0
CA14 3510.0
CA3 1780.0
CA9 1257.0
CA7 0.5
CA4 0.5
CA5A -1224.0
CA6 -1617.0
CA2 -4807.0
CA13 -7179.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CA1 4795.0
CA12 3566.0
CA14 3510.0
CA3 1780.0
CA9 1257.0
CA7 0.5
CA4 0.5
CA5A -1224.0
CA6 -1617.0
CA2 -4807.0
CA13 -7179.0


Sodium/Calcium exchangers

Sodium/Calcium exchangers
1299
set Sodium/Calcium exchangers
setSize 10
pANOVA 0.00609
s.dist 0.501
p.adjustANOVA 0.0155



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC24A1 4916
SLC8A2 4251
SLC24A4 3590
SLC24A5 2819
SLC8A1 2374
SLC8A3 872
SLC24A3 -1542
CALM1 -2593
SRI -6062
SLC24A2 -8867

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC24A1 4916
SLC8A2 4251
SLC24A4 3590
SLC24A5 2819
SLC8A1 2374
SLC8A3 872
SLC24A3 -1542
CALM1 -2593
SRI -6062
SLC24A2 -8867


Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
1450
set Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
setSize 17
pANOVA 0.000358
s.dist -0.5
p.adjustANOVA 0.00138



Top enriched genes

Top 20 genes
GeneID Gene Rank
EXOSC7 -14171
EXOSC8 -13934
XRN1 -13922
DCP2 -13634
MAPKAPK2 -13454
YWHAB -13231
DIS3 -13116
ZFP36 -11974
EXOSC5 -11442
EXOSC4 -9648
EXOSC1 -9383
EXOSC9 -9259
TNPO1 -9080
DCP1A -8275
EXOSC2 -5051
EXOSC6 -3793
EXOSC3 2155

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC7 -14171
EXOSC8 -13934
XRN1 -13922
DCP2 -13634
MAPKAPK2 -13454
YWHAB -13231
DIS3 -13116
ZFP36 -11974
EXOSC5 -11442
EXOSC4 -9648
EXOSC1 -9383
EXOSC9 -9259
TNPO1 -9080
DCP1A -8275
EXOSC2 -5051
EXOSC6 -3793
EXOSC3 2155


HDR through MMEJ (alt-NHEJ)

HDR through MMEJ (alt-NHEJ)
538
set HDR through MMEJ (alt-NHEJ)
setSize 11
pANOVA 0.0041
s.dist -0.5
p.adjustANOVA 0.011



Top enriched genes

Top 20 genes
GeneID Gene Rank
XRCC1 -14670
RBBP8 -14455
BRCA2 -14217
FEN1 -11872
PARP1 -10449
POLQ -9552
RAD52 -9267
PARP2 -8655
LIG3 -8445
RAD50 -5984
NBN -3216

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
XRCC1 -14670
RBBP8 -14455
BRCA2 -14217
FEN1 -11872
PARP1 -10449
POLQ -9552
RAD52 -9267
PARP2 -8655
LIG3 -8445
RAD50 -5984
NBN -3216


Aspirin ADME

Aspirin ADME
95
set Aspirin ADME
setSize 41
pANOVA 3.31e-08
s.dist 0.498
p.adjustANOVA 4.75e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALB 4865.0
CYP2D6 4583.0
GLYATL2 4532.0
UGT3A1 4332.0
SLCO2B1 4331.0
UGT1A1 4205.0
UGT2B7 4172.0
UGT1A8 3623.0
SLC22A7 3226.0
UGT1A9 2967.0
UGT1A4 2728.0
UGT1A3 2600.0
GLYAT 2546.0
GLYATL3 2179.0
UGT1A7 1490.0
ACSM5 1453.0
UGT1A5 1226.0
UGT1A6 1207.0
ACSM4 1179.0
CES2 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALB 4865.0
CYP2D6 4583.0
GLYATL2 4532.0
UGT3A1 4332.0
SLCO2B1 4331.0
UGT1A1 4205.0
UGT2B7 4172.0
UGT1A8 3623.0
SLC22A7 3226.0
UGT1A9 2967.0
UGT1A4 2728.0
UGT1A3 2600.0
GLYAT 2546.0
GLYATL3 2179.0
UGT1A7 1490.0
ACSM5 1453.0
UGT1A5 1226.0
UGT1A6 1207.0
ACSM4 1179.0
CES2 0.5
UGT2B11 0.5
UGT2A1 0.5
UGT2B4 0.5
GLYATL1 0.5
UGT2B10 0.5
CYP3A4 0.5
UGT2A3 0.5
CYP2C8 0.5
ACSM2A 0.5
BCHE 0.5
CES1 -1385.0
ABCC2 -1726.0
CYP2C19 -2668.0
SLC16A1 -3445.0
ABCC3 -4310.0
CYP2E1 -5724.0
UGT2B17 -6494.0
UGT2B15 -7633.0
UGT3A2 -8130.0
BSG -8961.0
CYP2C9 -9293.0


TICAM1, RIP1-mediated IKK complex recruitment

TICAM1, RIP1-mediated IKK complex recruitment
1343
set TICAM1, RIP1-mediated IKK complex recruitment
setSize 18
pANOVA 0.000267
s.dist -0.496
p.adjustANOVA 0.00105



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -15008
UBE2D2 -14346
RPS27A -13898
TRAF6 -13778
UBB -13480
TICAM1 -13200
UBE2V1 -12623
CHUK -12092
UBE2D3 -11646
RIPK3 -10187
IKBKB -9585
BIRC2 -8528
UBE2D1 -7931
UBA52 -6091
BIRC3 -5958
UBE2N -5801
RIPK1 -4852
TLR3 -1597

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -15008
UBE2D2 -14346
RPS27A -13898
TRAF6 -13778
UBB -13480
TICAM1 -13200
UBE2V1 -12623
CHUK -12092
UBE2D3 -11646
RIPK3 -10187
IKBKB -9585
BIRC2 -8528
UBE2D1 -7931
UBA52 -6091
BIRC3 -5958
UBE2N -5801
RIPK1 -4852
TLR3 -1597


Miscellaneous substrates

Miscellaneous substrates
728
set Miscellaneous substrates
setSize 12
pANOVA 0.00295
s.dist 0.495
p.adjustANOVA 0.00825



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP4F3 4869
CYP2D6 4583
CYP4B1 4511
CYP4F22 2702
CYP3A43 1711
CYP2S1 1516
CYP2W1 1484
CYP4A22 -1714
CYP4F2 -2100
CYP4F11 -2760
CYP4A11 -6249
CYP2U1 -9495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F3 4869
CYP2D6 4583
CYP4B1 4511
CYP4F22 2702
CYP3A43 1711
CYP2S1 1516
CYP2W1 1484
CYP4A22 -1714
CYP4F2 -2100
CYP4F11 -2760
CYP4A11 -6249
CYP2U1 -9495


Transport of the SLBP Dependant Mature mRNA

Transport of the SLBP Dependant Mature mRNA
1443
set Transport of the SLBP Dependant Mature mRNA
setSize 32
pANOVA 1.29e-06
s.dist -0.494
p.adjustANOVA 1.12e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NCBP2 -12591
NUP160 -11901
NUP214 -11818
EIF4E -11780
NUP107 -11483
SLBP -11308
NUP43 -10931
NXF1 -10633
NUP188 -10212
POM121 -9923

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NCBP2 -12591
NUP160 -11901
NUP214 -11818
EIF4E -11780
NUP107 -11483
SLBP -11308
NUP43 -10931
NXF1 -10633
NUP188 -10212
POM121 -9923
AAAS -9465
TPR -9227
NUP50 -8702
NUP54 -7718
NUP210 -7666
NUP88 -7229
RANBP2 -7111
NUP155 -6576
NUP133 -3417
NUP35 -2247
NUP62 -1745
NUP93 2098


Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization
526
set Golgi Cisternae Pericentriolar Stack Reorganization
setSize 14
pANOVA 0.00148
s.dist -0.491
p.adjustANOVA 0.00461



Top enriched genes

Top 20 genes
GeneID Gene Rank
BLZF1 -14926.5
USO1 -14791.0
RAB1B -14378.0
CCNB2 -12466.0
MAPK3 -11432.0
RAB1A -10196.0
CDK1 -9233.5
GORASP2 -8980.0
RAB2A -8853.0
CCNB1 -7956.0
MAPK1 -7045.0
PLK1 -6621.0
GOLGA2 -6540.0
GORASP1 -6276.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BLZF1 -14926.5
USO1 -14791.0
RAB1B -14378.0
CCNB2 -12466.0
MAPK3 -11432.0
RAB1A -10196.0
CDK1 -9233.5
GORASP2 -8980.0
RAB2A -8853.0
CCNB1 -7956.0
MAPK1 -7045.0
PLK1 -6621.0
GOLGA2 -6540.0
GORASP1 -6276.0


Transport of the SLBP independent Mature mRNA

Transport of the SLBP independent Mature mRNA
1444
set Transport of the SLBP independent Mature mRNA
setSize 31
pANOVA 2.31e-06
s.dist -0.49
p.adjustANOVA 1.85e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NCBP2 -12591
NUP160 -11901
NUP214 -11818
EIF4E -11780
NUP107 -11483
NUP43 -10931
NXF1 -10633
NUP188 -10212
POM121 -9923
AAAS -9465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NCBP2 -12591
NUP160 -11901
NUP214 -11818
EIF4E -11780
NUP107 -11483
NUP43 -10931
NXF1 -10633
NUP188 -10212
POM121 -9923
AAAS -9465
TPR -9227
NUP50 -8702
NUP54 -7718
NUP210 -7666
NUP88 -7229
RANBP2 -7111
NUP155 -6576
NUP133 -3417
NUP35 -2247
NUP62 -1745
NUP93 2098


Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)
209
set Class C/3 (Metabotropic glutamate/pheromone receptors)
setSize 35
pANOVA 5.32e-07
s.dist 0.49
p.adjustANOVA 5.72e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAS2R31 4666.0
TAS2R14 4308.0
TAS2R30 4126.0
TAS2R43 4029.0
TAS2R5 4028.0
GRM5 3454.0
GRM4 3368.0
GRM6 2946.0
GRM1 2661.0
GABBR2 2532.0
TAS2R3 2263.0
TAS1R2 2168.0
TAS2R38 1828.0
CASR 1624.0
TAS1R3 1099.0
TAS2R19 0.5
TAS2R7 0.5
TAS2R60 0.5
TAS2R41 0.5
TAS2R20 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAS2R31 4666.0
TAS2R14 4308.0
TAS2R30 4126.0
TAS2R43 4029.0
TAS2R5 4028.0
GRM5 3454.0
GRM4 3368.0
GRM6 2946.0
GRM1 2661.0
GABBR2 2532.0
TAS2R3 2263.0
TAS1R2 2168.0
TAS2R38 1828.0
CASR 1624.0
TAS1R3 1099.0
TAS2R19 0.5
TAS2R7 0.5
TAS2R60 0.5
TAS2R41 0.5
TAS2R20 0.5
TAS2R50 0.5
TAS2R1 0.5
TAS2R13 0.5
TAS2R9 0.5
TAS2R46 0.5
TAS1R1 -890.0
GRM3 -2461.0
TAS2R39 -2699.0
TAS2R4 -3176.0
TAS2R40 -4044.0
TAS2R16 -4918.0
GRM8 -5334.0
GABBR1 -8133.0
GRM2 -8988.0
GRM7 -9481.0


Spry regulation of FGF signaling

Spry regulation of FGF signaling
1302
set Spry regulation of FGF signaling
setSize 16
pANOVA 0.000697
s.dist -0.49
p.adjustANOVA 0.00242



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -15008
PTPN11 -14025
RPS27A -13898
SPRY2 -13878
PPP2CA -13481
UBB -13480
PPP2R1A -12937
MAPK3 -11432
GRB2 -10720
CBL -9643
BRAF -8774
PPP2CB -7504
MAPK1 -7045
UBA52 -6091
SRC -3580
MKNK1 2014

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -15008
PTPN11 -14025
RPS27A -13898
SPRY2 -13878
PPP2CA -13481
UBB -13480
PPP2R1A -12937
MAPK3 -11432
GRB2 -10720
CBL -9643
BRAF -8774
PPP2CB -7504
MAPK1 -7045
UBA52 -6091
SRC -3580
MKNK1 2014


Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA
948
set Processing of Capped Intronless Pre-mRNA
setSize 28
pANOVA 7.71e-06
s.dist -0.488
p.adjustANOVA 4.97e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLP1 -15018
SYMPK -14876
CSTF2T -14444
NCBP1 -14270
SNRPF -14115
SNRPG -14046
NUDT21 -13923
CPSF2 -13226
SNRPD3 -13147
PCF11 -12858
CSTF1 -12771
NCBP2 -12591
ZNF473 -11718
SLBP -11308
SNRPB -11084
SNRPE -11073
FIP1L1 -8308
PAPOLA -7468
CSTF3 -7076
CPSF3 -6879

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLP1 -15018
SYMPK -14876
CSTF2T -14444
NCBP1 -14270
SNRPF -14115
SNRPG -14046
NUDT21 -13923
CPSF2 -13226
SNRPD3 -13147
PCF11 -12858
CSTF1 -12771
NCBP2 -12591
ZNF473 -11718
SLBP -11308
SNRPB -11084
SNRPE -11073
FIP1L1 -8308
PAPOLA -7468
CSTF3 -7076
CPSF3 -6879
PABPN1 -6875
CPSF6 -6012
CPSF7 -5895
WDR33 -5261
LSM10 -4980
CPSF4 -3669
CPSF1 -3188
LSM11 -2573


Transport of Mature mRNA derived from an Intron-Containing Transcript

Transport of Mature mRNA derived from an Intron-Containing Transcript
1435
set Transport of Mature mRNA derived from an Intron-Containing Transcript
setSize 54
pANOVA 5.36e-10
s.dist -0.488
p.adjustANOVA 1.16e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBM8A -15015
NUP205 -14950
CDC40 -14458
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
EIF4A3 -13510
SEH1L -13390
CASC3 -13222
POM121C -13149
MAGOH -13115
THOC5 -12785
NXT1 -12751
NCBP2 -12591
DHX38 -12301
RNPS1 -12222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBM8A -15015
NUP205 -14950
CDC40 -14458
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
EIF4A3 -13510
SEH1L -13390
CASC3 -13222
POM121C -13149
MAGOH -13115
THOC5 -12785
NXT1 -12751
NCBP2 -12591
DHX38 -12301
RNPS1 -12222
NUP160 -11901
ZC3H11A -11878
NUP214 -11818
THOC6 -11814
FYTTD1 -11720
NUP107 -11483
SLU7 -11159
U2AF1 -11111
MAGOHB -11071
POLDIP3 -11069
THOC1 -11000
NUP43 -10931
NXF1 -10633
THOC7 -10468
SARNP -10217
NUP188 -10212
POM121 -9923
AAAS -9465
TPR -9227
U2AF1L4 -8756
NUP50 -8702
NUP54 -7718
NUP210 -7666
NUP88 -7229
RANBP2 -7111
NUP155 -6576
NUP133 -3417
U2AF2 -3247
THOC3 -2826
NUP35 -2247
NUP62 -1745
SRRM1 1242
NUP93 2098
GLE1 4747


TICAM1-dependent activation of IRF3/IRF7

TICAM1-dependent activation of IRF3/IRF7
1344
set TICAM1-dependent activation of IRF3/IRF7
setSize 12
pANOVA 0.00385
s.dist -0.482
p.adjustANOVA 0.0104



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -15008
RPS27A -13898
TBK1 -13651
UBB -13480
TICAM1 -13200
TANK -12388
IRF7 -11753
IRF3 -10423
TRAF3 -8404
UBA52 -6091
TLR3 -1597
IKBKE 1210

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -15008
RPS27A -13898
TBK1 -13651
UBB -13480
TICAM1 -13200
TANK -12388
IRF7 -11753
IRF3 -10423
TRAF3 -8404
UBA52 -6091
TLR3 -1597
IKBKE 1210


Export of Viral Ribonucleoproteins from Nucleus

Export of Viral Ribonucleoproteins from Nucleus
394
set Export of Viral Ribonucleoproteins from Nucleus
setSize 30
pANOVA 5.31e-06
s.dist -0.48
p.adjustANOVA 3.6e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPA1A -15075
NUP205 -14950
XPO1 -14554
NUP85 -14314
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NUP160 -11901
NUP214 -11818
NUP107 -11483
NUP43 -10931
NUP188 -10212
POM121 -9923
AAAS -9465
TPR -9227
NUP50 -8702

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA1A -15075
NUP205 -14950
XPO1 -14554
NUP85 -14314
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NUP160 -11901
NUP214 -11818
NUP107 -11483
NUP43 -10931
NUP188 -10212
POM121 -9923
AAAS -9465
TPR -9227
NUP50 -8702
NUP54 -7718
NUP210 -7666
NUP88 -7229
RANBP2 -7111
RAN -6650
NUP155 -6576
NUP133 -3417
NUP35 -2247
NUP62 -1745
NUP93 2098


Initial triggering of complement

Initial triggering of complement
595
set Initial triggering of complement
setSize 21
pANOVA 0.000141
s.dist 0.48
p.adjustANOVA 0.000586



Top enriched genes

Top 20 genes
GeneID Gene Rank
COLEC10 4746.0
CRP 4472.0
C2 3920.0
CFD 3696.0
C1QA 2928.0
MASP2 2652.0
FCN3 1971.0
C1QB 1366.0
FCN1 1262.0
MASP1 1108.0
FCN2 0.5
C4B -913.5
C4A -913.5
COLEC11 -1811.0
C1S -1993.0
MBL2 -2140.0
CFB -3064.0
C1R -4157.0
C1QC -4914.0
C3 -5779.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COLEC10 4746.0
CRP 4472.0
C2 3920.0
CFD 3696.0
C1QA 2928.0
MASP2 2652.0
FCN3 1971.0
C1QB 1366.0
FCN1 1262.0
MASP1 1108.0
FCN2 0.5
C4B -913.5
C4A -913.5
COLEC11 -1811.0
C1S -1993.0
MBL2 -2140.0
CFB -3064.0
C1R -4157.0
C1QC -4914.0
C3 -5779.0
GZMM -7461.0


Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
437
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.00894
s.dist -0.477
p.adjustANOVA 0.022



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCT8 -15002
CCT4 -14519
ACTB -14216
TCP1 -13080
CCT5 -12266
CCT6A -9523
CCT3 -9204
CCT6B -6665
CCT7 -5605
CCT2 1609

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -15002
CCT4 -14519
ACTB -14216
TCP1 -13080
CCT5 -12266
CCT6A -9523
CCT3 -9204
CCT6B -6665
CCT7 -5605
CCT2 1609


Nuclear Pore Complex (NPC) Disassembly

Nuclear Pore Complex (NPC) Disassembly
824
set Nuclear Pore Complex (NPC) Disassembly
setSize 33
pANOVA 2.18e-06
s.dist -0.476
p.adjustANOVA 1.75e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
SEH1L -13390
POM121C -13149
NEK7 -12718
CCNB2 -12466
NEK9 -11990
NUP160 -11901
NUP214 -11818
NUP107 -11483
NUP43 -10931
NEK6 -10228
NUP188 -10212
POM121 -9923
AAAS -9465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUP205 -14950.0
NUP85 -14314.0
SEC13 -14038.0
NUP153 -13814.0
NUP98 -13731.0
RAE1 -13578.0
NUP37 -13558.0
SEH1L -13390.0
POM121C -13149.0
NEK7 -12718.0
CCNB2 -12466.0
NEK9 -11990.0
NUP160 -11901.0
NUP214 -11818.0
NUP107 -11483.0
NUP43 -10931.0
NEK6 -10228.0
NUP188 -10212.0
POM121 -9923.0
AAAS -9465.0
CDK1 -9233.5
TPR -9227.0
NUP50 -8702.0
CCNB1 -7956.0
NUP54 -7718.0
NUP210 -7666.0
NUP88 -7229.0
RANBP2 -7111.0
NUP155 -6576.0
NUP133 -3417.0
NUP35 -2247.0
NUP62 -1745.0
NUP93 2098.0


Metabolism of non-coding RNA

Metabolism of non-coding RNA
714
set Metabolism of non-coding RNA
setSize 48
pANOVA 1.54e-08
s.dist -0.472
p.adjustANOVA 2.32e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
NCBP1 -14270
SNRPF -14115
SNRPG -14046
SEC13 -14038
PRMT5 -13913
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
DDX20 -13524
SEH1L -13390
SNRPD2 -13210
POM121C -13149
SNRPD3 -13147
NCBP2 -12591
NUP160 -11901
NUP214 -11818
NUP107 -11483

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUP205 -14950.0
NUP85 -14314.0
NCBP1 -14270.0
SNRPF -14115.0
SNRPG -14046.0
SEC13 -14038.0
PRMT5 -13913.0
NUP153 -13814.0
NUP98 -13731.0
RAE1 -13578.0
NUP37 -13558.0
DDX20 -13524.0
SEH1L -13390.0
SNRPD2 -13210.0
POM121C -13149.0
SNRPD3 -13147.0
NCBP2 -12591.0
NUP160 -11901.0
NUP214 -11818.0
NUP107 -11483.0
GEMIN5 -11136.0
SNRPB -11084.0
SNRPE -11073.0
NUP43 -10931.0
NUP188 -10212.0
GEMIN6 -10031.0
POM121 -9923.0
SNUPN -9647.0
GEMIN4 -9587.0
AAAS -9465.0
TGS1 -9344.0
TPR -9227.0
CLNS1A -8865.0
NUP50 -8702.0
NUP54 -7718.0
NUP210 -7666.0
WDR77 -7407.0
NUP88 -7229.0
RANBP2 -7111.0
NUP155 -6576.0
SMN1 -5115.5
GEMIN7 -4571.0
NUP133 -3417.0
SNRPD1 -2301.0
NUP35 -2247.0
NUP62 -1745.0
PHAX -744.0
NUP93 2098.0


snRNP Assembly

snRNP Assembly
1515
set snRNP Assembly
setSize 48
pANOVA 1.54e-08
s.dist -0.472
p.adjustANOVA 2.32e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUP205 -14950
NUP85 -14314
NCBP1 -14270
SNRPF -14115
SNRPG -14046
SEC13 -14038
PRMT5 -13913
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
DDX20 -13524
SEH1L -13390
SNRPD2 -13210
POM121C -13149
SNRPD3 -13147
NCBP2 -12591
NUP160 -11901
NUP214 -11818
NUP107 -11483

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUP205 -14950.0
NUP85 -14314.0
NCBP1 -14270.0
SNRPF -14115.0
SNRPG -14046.0
SEC13 -14038.0
PRMT5 -13913.0
NUP153 -13814.0
NUP98 -13731.0
RAE1 -13578.0
NUP37 -13558.0
DDX20 -13524.0
SEH1L -13390.0
SNRPD2 -13210.0
POM121C -13149.0
SNRPD3 -13147.0
NCBP2 -12591.0
NUP160 -11901.0
NUP214 -11818.0
NUP107 -11483.0
GEMIN5 -11136.0
SNRPB -11084.0
SNRPE -11073.0
NUP43 -10931.0
NUP188 -10212.0
GEMIN6 -10031.0
POM121 -9923.0
SNUPN -9647.0
GEMIN4 -9587.0
AAAS -9465.0
TGS1 -9344.0
TPR -9227.0
CLNS1A -8865.0
NUP50 -8702.0
NUP54 -7718.0
NUP210 -7666.0
WDR77 -7407.0
NUP88 -7229.0
RANBP2 -7111.0
NUP155 -6576.0
SMN1 -5115.5
GEMIN7 -4571.0
NUP133 -3417.0
SNRPD1 -2301.0
NUP35 -2247.0
NUP62 -1745.0
PHAX -744.0
NUP93 2098.0


SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1166
set SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
setSize 32
pANOVA 3.92e-06
s.dist -0.471
p.adjustANOVA 2.85e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYC -15041
UBC -15008
TGIF2 -14995
RNF111 -14592
TGIF1 -14546
SP1 -14421
RPS27A -13898
JUNB -13845
UBB -13480
CCNC -13406
HDAC1 -12668
CCNT1 -12652
CDK9 -12242
MAPK3 -11432
MEN1 -11234
RBL1 -10910
SMAD3 -10462
E2F5 -10092
SMAD4 -9638
CCNK -9256

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYC -15041.0
UBC -15008.0
TGIF2 -14995.0
RNF111 -14592.0
TGIF1 -14546.0
SP1 -14421.0
RPS27A -13898.0
JUNB -13845.0
UBB -13480.0
CCNC -13406.0
HDAC1 -12668.0
CCNT1 -12652.0
CDK9 -12242.0
MAPK3 -11432.0
MEN1 -11234.0
RBL1 -10910.0
SMAD3 -10462.0
E2F5 -10092.0
SMAD4 -9638.0
CCNK -9256.0
SMAD7 -8615.0
E2F4 -8119.0
WWTR1 -7357.0
MAPK1 -7045.0
SMAD2 -6515.0
UBA52 -6091.0
CDK8 -4025.0
CCNT2 -3985.0
SERPINE1 -3668.0
CDKN2B -2256.0
TFDP1 -1498.0
TFDP2 0.5


Transport of Mature Transcript to Cytoplasm

Transport of Mature Transcript to Cytoplasm
1433
set Transport of Mature Transcript to Cytoplasm
setSize 63
pANOVA 9.94e-11
s.dist -0.471
p.adjustANOVA 2.65e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBM8A -15015
NUP205 -14950
SYMPK -14876
CDC40 -14458
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
EIF4A3 -13510
SEH1L -13390
CPSF2 -13226
CASC3 -13222
POM121C -13149
MAGOH -13115
THOC5 -12785
NXT1 -12751
NCBP2 -12591

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBM8A -15015
NUP205 -14950
SYMPK -14876
CDC40 -14458
NUP85 -14314
NCBP1 -14270
SEC13 -14038
NUP153 -13814
NUP98 -13731
RAE1 -13578
NUP37 -13558
EIF4A3 -13510
SEH1L -13390
CPSF2 -13226
CASC3 -13222
POM121C -13149
MAGOH -13115
THOC5 -12785
NXT1 -12751
NCBP2 -12591
DHX38 -12301
RNPS1 -12222
NUP160 -11901
ZC3H11A -11878
NUP214 -11818
THOC6 -11814
EIF4E -11780
FYTTD1 -11720
NUP107 -11483
SLBP -11308
SLU7 -11159
U2AF1 -11111
MAGOHB -11071
POLDIP3 -11069
THOC1 -11000
NUP43 -10931
NXF1 -10633
THOC7 -10468
SARNP -10217
NUP188 -10212
POM121 -9923
AAAS -9465
TPR -9227
U2AF1L4 -8756
NUP50 -8702
FIP1L1 -8308
NUP54 -7718
NUP210 -7666
NUP88 -7229
RANBP2 -7111
CPSF3 -6879
NUP155 -6576
WDR33 -5261
CPSF4 -3669
NUP133 -3417
U2AF2 -3247
CPSF1 -3188
THOC3 -2826
NUP35 -2247
NUP62 -1745
SRRM1 1242
NUP93 2098
GLE1 4747


mRNA decay by 5’ to 3’ exoribonuclease

mRNA decay by 5’ to 3’ exoribonuclease
1500
set mRNA decay by 5’ to 3’ exoribonuclease
setSize 15
pANOVA 0.00167
s.dist -0.469
p.adjustANOVA 0.00511



Top enriched genes

Top 20 genes
GeneID Gene Rank
LSM4 -14573
LSM5 -14394
XRN1 -13922
DCP2 -13634
LSM1 -13610
PATL1 -12477
DDX6 -12447
LSM7 -11482
EDC4 -9547
DCP1A -8275
LSM6 -8241
LSM3 -6461
LSM2 -5787
EDC3 -5346
DCP1B 3832

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LSM4 -14573
LSM5 -14394
XRN1 -13922
DCP2 -13634
LSM1 -13610
PATL1 -12477
DDX6 -12447
LSM7 -11482
EDC4 -9547
DCP1A -8275
LSM6 -8241
LSM3 -6461
LSM2 -5787
EDC3 -5346
DCP1B 3832


FGFR2 alternative splicing

FGFR2 alternative splicing
409
set FGFR2 alternative splicing
setSize 25
pANOVA 5.24e-05
s.dist -0.467
p.adjustANOVA 0.000249



Top enriched genes

Top 20 genes
GeneID Gene Rank
HNRNPA1 -15026
POLR2I -14951
NCBP1 -14270
TIAL1 -13749
ESRP1 -13502
TIA1 -12704
NCBP2 -12591
POLR2E -12584
HNRNPF -12424
GTF2F2 -11380
HNRNPH1 -11007
POLR2G -10614
POLR2K -10264
GTF2F1 -9747
POLR2H -9644
POLR2D -9250
POLR2A -9247
POLR2B -8522
POLR2J -8239
HNRNPM -7727

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HNRNPA1 -15026
POLR2I -14951
NCBP1 -14270
TIAL1 -13749
ESRP1 -13502
TIA1 -12704
NCBP2 -12591
POLR2E -12584
HNRNPF -12424
GTF2F2 -11380
HNRNPH1 -11007
POLR2G -10614
POLR2K -10264
GTF2F1 -9747
POLR2H -9644
POLR2D -9250
POLR2A -9247
POLR2B -8522
POLR2J -8239
HNRNPM -7727
ESRP2 -7297
PTBP1 -3848
POLR2C -2029
POLR2L -1858
POLR2F -1062


Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs
950
set Processing of Intronless Pre-mRNAs
setSize 19
pANOVA 0.000454
s.dist -0.465
p.adjustANOVA 0.00166



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLP1 -15018
SYMPK -14876
CSTF2T -14444
NCBP1 -14270
NUDT21 -13923
CPSF2 -13226
PCF11 -12858
CSTF1 -12771
NCBP2 -12591
FIP1L1 -8308
PAPOLA -7468
CSTF3 -7076
CPSF3 -6879
PABPN1 -6875
CPSF6 -6012
CPSF7 -5895
WDR33 -5261
CPSF4 -3669
CPSF1 -3188

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLP1 -15018
SYMPK -14876
CSTF2T -14444
NCBP1 -14270
NUDT21 -13923
CPSF2 -13226
PCF11 -12858
CSTF1 -12771
NCBP2 -12591
FIP1L1 -8308
PAPOLA -7468
CSTF3 -7076
CPSF3 -6879
PABPN1 -6875
CPSF6 -6012
CPSF7 -5895
WDR33 -5261
CPSF4 -3669
CPSF1 -3188


p75NTR recruits signalling complexes

p75NTR recruits signalling complexes
1510
set p75NTR recruits signalling complexes
setSize 12
pANOVA 0.00536
s.dist -0.464
p.adjustANOVA 0.0139



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBC -15008
SQSTM1 -14793
MYD88 -14525
RPS27A -13898
TRAF6 -13778
UBB -13480
IKBKB -9585
PRKCI -9123
UBA52 -6091
NGFR -5453
RIPK2 -1846
NGF 1016

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBC -15008
SQSTM1 -14793
MYD88 -14525
RPS27A -13898
TRAF6 -13778
UBB -13480
IKBKB -9585
PRKCI -9123
UBA52 -6091
NGFR -5453
RIPK2 -1846
NGF 1016


Removal of the Flap Intermediate from the C-strand

Removal of the Flap Intermediate from the C-strand
1118
set Removal of the Flap Intermediate from the C-strand
setSize 17
pANOVA 0.00094
s.dist -0.463
p.adjustANOVA 0.00315



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNA2 -14973
TINF2 -14969
WRN -14575
TERF2 -13817
POLD1 -13196
POLD4 -13184
FEN1 -11872
POLD3 -11683
POT1 -10443
PCNA -9392
TERF2IP -9355
RPA3 -8846
TERF1 -7612
ACD -6671
POLD2 -4240
RPA2 -942
RPA1 800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNA2 -14973
TINF2 -14969
WRN -14575
TERF2 -13817
POLD1 -13196
POLD4 -13184
FEN1 -11872
POLD3 -11683
POT1 -10443
PCNA -9392
TERF2IP -9355
RPA3 -8846
TERF1 -7612
ACD -6671
POLD2 -4240
RPA2 -942
RPA1 800


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.2.4    GGally_2.1.2     ggplot2_3.3.6    reshape2_1.4.4  
##  [5] beeswarm_0.4.0   gplots_3.1.3     gtools_3.9.2     tibble_3.1.7    
##  [9] echarts4r_0.4.3  mitch_1.4.1      eulerr_6.1.1     kableExtra_1.3.4
## [13] dplyr_1.0.9     
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.8.3       svglite_2.1.0      rprojroot_2.0.3    assertthat_0.2.1  
##  [5] digest_0.6.29      utf8_1.2.2         mime_0.12          R6_2.5.1          
##  [9] plyr_1.8.7         evaluate_0.15      httr_1.4.3         highr_0.9         
## [13] pillar_1.7.0       rlang_1.0.2        rstudioapi_0.13    jquerylib_0.1.4   
## [17] rmarkdown_2.14     desc_1.4.1         webshot_0.5.3      stringr_1.4.0     
## [21] htmlwidgets_1.5.4  munsell_0.5.0      shiny_1.7.1        compiler_4.2.0    
## [25] httpuv_1.6.5       xfun_0.30          pkgconfig_2.0.3    systemfonts_1.0.4 
## [29] htmltools_0.5.2    tidyselect_1.1.2   gridExtra_2.3      reshape_0.8.9     
## [33] fansi_1.0.3        viridisLite_0.4.0  withr_2.5.0        crayon_1.5.1      
## [37] later_1.3.0        brio_1.1.3         bitops_1.0-7       MASS_7.3-57       
## [41] grid_4.2.0         jsonlite_1.8.0     xtable_1.8-4       gtable_0.3.0      
## [45] lifecycle_1.0.1    DBI_1.1.2          magrittr_2.0.3     scales_1.2.0      
## [49] KernSmooth_2.23-20 cli_3.3.0          stringi_1.7.6      promises_1.2.0.1  
## [53] testthat_3.1.4     xml2_1.3.3         bslib_0.3.1        ellipsis_0.3.2    
## [57] generics_0.1.2     vctrs_0.4.1        RColorBrewer_1.1-3 tools_4.2.0       
## [61] glue_1.6.2         purrr_0.3.4        fastmap_1.1.0      yaml_2.3.5        
## [65] colorspace_2.0-3   caTools_1.18.2     rvest_1.0.2        knitr_1.39        
## [69] sass_0.4.1

END of report