date generated: 2022-05-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             metric
## PSMB8    -7.305627
## PPT2     -5.941684
## PSMB9    -8.456132
## PEG10    -6.426739
## SGCE     -6.469123
## KIAA1949 -5.842438
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 9840
duplicated_genes_present 0
num_profile_genes_in_sets 5255
num_profile_genes_not_in_sets 4585

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1377
num_genesets_included 1169

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Purine catabolism 10 0.009170 -0.476 0.1580
Meiotic recombination 19 0.000838 -0.443 0.0515
p75NTR signals via NF-kB 11 0.011800 -0.439 0.1640
Negative regulation of NMDA receptor-mediated neuronal transmission 11 0.012600 0.435 0.1730
Signaling by Leptin 10 0.018200 0.431 0.2090
Signaling by BMP 14 0.005530 0.428 0.1300
IKK complex recruitment mediated by RIP1 17 0.006630 -0.380 0.1380
Ras activation upon Ca2+ influx through NMDA receptor 10 0.039600 0.376 0.2790
Potassium Channels 23 0.001890 0.374 0.0919
SARS-CoV-2 modulates autophagy 10 0.046700 -0.363 0.3130
tRNA Aminoacylation 22 0.003210 -0.363 0.1170
Processing of Intronless Pre-mRNAs 15 0.015300 -0.362 0.1970
Mitochondrial tRNA aminoacylation 17 0.010200 -0.360 0.1600
Mucopolysaccharidoses 10 0.053200 0.353 0.3310
HDMs demethylate histones 15 0.019900 -0.347 0.2190
Collagen degradation 10 0.059400 0.344 0.3420
Erythropoietin activates RAS 10 0.059400 0.344 0.3420
Interleukin-20 family signaling 13 0.036200 0.336 0.2720
RIPK1-mediated regulated necrosis 24 0.004580 -0.334 0.1170
Regulation of necroptotic cell death 24 0.004580 -0.334 0.1170
Activation of G protein gated Potassium channels 10 0.070900 0.330 0.3610
G protein gated Potassium channels 10 0.070900 0.330 0.3610
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 10 0.070900 0.330 0.3610
Caspase activation via Death Receptors in the presence of ligand 10 0.071100 -0.330 0.3610
Activation of kainate receptors upon glutamate binding 15 0.027200 0.329 0.2480
Signaling by Erythropoietin 18 0.015800 0.329 0.1970
Translesion Synthesis by POLH 16 0.023500 -0.327 0.2290
Impaired BRCA2 binding to RAD51 30 0.001960 -0.327 0.0919
Mitochondrial calcium ion transport 14 0.034700 0.326 0.2680
Golgi Cisternae Pericentriolar Stack Reorganization 14 0.035800 -0.324 0.2720
Interleukin-10 signaling 12 0.052100 0.324 0.3270
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 0.030800 -0.322 0.2610
Chaperone Mediated Autophagy 12 0.054400 -0.321 0.3360
Downregulation of ERBB2 signaling 17 0.022200 -0.320 0.2230
TICAM1, RIP1-mediated IKK complex recruitment 17 0.022500 -0.320 0.2230
RHO GTPases activate CIT 14 0.038700 -0.319 0.2760
Glycogen synthesis 11 0.066900 -0.319 0.3600
Signaling by WNT in cancer 22 0.010400 0.316 0.1600
Cytosolic sulfonation of small molecules 10 0.084700 0.315 0.3900
Negative regulation of FLT3 10 0.084800 -0.315 0.3900
Cell-cell junction organization 12 0.059300 0.315 0.3420
Generation of second messenger molecules 12 0.060600 0.313 0.3430
Meiosis 39 0.000785 -0.311 0.0510
Prostacyclin signalling through prostacyclin receptor 10 0.089200 0.310 0.3940
Assembly and cell surface presentation of NMDA receptors 12 0.063700 0.309 0.3500
Resolution of D-loop Structures through Holliday Junction Intermediates 24 0.009010 -0.308 0.1580
mRNA 3’-end processing 30 0.004180 -0.302 0.1170
Long-term potentiation 10 0.098900 0.301 0.4100
Myogenesis 13 0.061000 -0.300 0.3430
Presynaptic phase of homologous DNA pairing and strand exchange 32 0.003670 -0.297 0.1170


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Purine catabolism 10 9.17e-03 -0.476000 0.158000
Meiotic recombination 19 8.38e-04 -0.443000 0.051500
p75NTR signals via NF-kB 11 1.18e-02 -0.439000 0.164000
Negative regulation of NMDA receptor-mediated neuronal transmission 11 1.26e-02 0.435000 0.173000
Signaling by Leptin 10 1.82e-02 0.431000 0.209000
Signaling by BMP 14 5.53e-03 0.428000 0.130000
IKK complex recruitment mediated by RIP1 17 6.63e-03 -0.380000 0.138000
Ras activation upon Ca2+ influx through NMDA receptor 10 3.96e-02 0.376000 0.279000
Potassium Channels 23 1.89e-03 0.374000 0.091900
SARS-CoV-2 modulates autophagy 10 4.67e-02 -0.363000 0.313000
tRNA Aminoacylation 22 3.21e-03 -0.363000 0.117000
Processing of Intronless Pre-mRNAs 15 1.53e-02 -0.362000 0.197000
Mitochondrial tRNA aminoacylation 17 1.02e-02 -0.360000 0.160000
Mucopolysaccharidoses 10 5.32e-02 0.353000 0.331000
HDMs demethylate histones 15 1.99e-02 -0.347000 0.219000
Collagen degradation 10 5.94e-02 0.344000 0.342000
Erythropoietin activates RAS 10 5.94e-02 0.344000 0.342000
Interleukin-20 family signaling 13 3.62e-02 0.336000 0.272000
RIPK1-mediated regulated necrosis 24 4.58e-03 -0.334000 0.117000
Regulation of necroptotic cell death 24 4.58e-03 -0.334000 0.117000
Activation of G protein gated Potassium channels 10 7.09e-02 0.330000 0.361000
G protein gated Potassium channels 10 7.09e-02 0.330000 0.361000
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 10 7.09e-02 0.330000 0.361000
Caspase activation via Death Receptors in the presence of ligand 10 7.11e-02 -0.330000 0.361000
Activation of kainate receptors upon glutamate binding 15 2.72e-02 0.329000 0.248000
Signaling by Erythropoietin 18 1.58e-02 0.329000 0.197000
Translesion Synthesis by POLH 16 2.35e-02 -0.327000 0.229000
Impaired BRCA2 binding to RAD51 30 1.96e-03 -0.327000 0.091900
Mitochondrial calcium ion transport 14 3.47e-02 0.326000 0.268000
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.58e-02 -0.324000 0.272000
Interleukin-10 signaling 12 5.21e-02 0.324000 0.327000
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 3.08e-02 -0.322000 0.261000
Chaperone Mediated Autophagy 12 5.44e-02 -0.321000 0.336000
Downregulation of ERBB2 signaling 17 2.22e-02 -0.320000 0.223000
TICAM1, RIP1-mediated IKK complex recruitment 17 2.25e-02 -0.320000 0.223000
RHO GTPases activate CIT 14 3.87e-02 -0.319000 0.276000
Glycogen synthesis 11 6.69e-02 -0.319000 0.360000
Signaling by WNT in cancer 22 1.04e-02 0.316000 0.160000
Cytosolic sulfonation of small molecules 10 8.47e-02 0.315000 0.390000
Negative regulation of FLT3 10 8.48e-02 -0.315000 0.390000
Cell-cell junction organization 12 5.93e-02 0.315000 0.342000
Generation of second messenger molecules 12 6.06e-02 0.313000 0.343000
Meiosis 39 7.85e-04 -0.311000 0.051000
Prostacyclin signalling through prostacyclin receptor 10 8.92e-02 0.310000 0.394000
Assembly and cell surface presentation of NMDA receptors 12 6.37e-02 0.309000 0.350000
Resolution of D-loop Structures through Holliday Junction Intermediates 24 9.01e-03 -0.308000 0.158000
mRNA 3’-end processing 30 4.18e-03 -0.302000 0.117000
Long-term potentiation 10 9.89e-02 0.301000 0.410000
Myogenesis 13 6.10e-02 -0.300000 0.343000
Presynaptic phase of homologous DNA pairing and strand exchange 32 3.67e-03 -0.297000 0.117000
Resolution of D-Loop Structures 25 1.05e-02 -0.296000 0.160000
FOXO-mediated transcription of cell death genes 14 5.65e-02 0.294000 0.338000
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 21 2.09e-02 -0.291000 0.219000
Miscellaneous transport and binding events 13 6.90e-02 -0.291000 0.361000
Processing of Capped Intronless Pre-mRNA 23 1.58e-02 -0.291000 0.197000
Inwardly rectifying K+ channels 11 1.00e-01 0.286000 0.413000
Class B/2 (Secretin family receptors) 26 1.15e-02 0.286000 0.163000
Leading Strand Synthesis 12 8.86e-02 -0.284000 0.394000
Polymerase switching 12 8.86e-02 -0.284000 0.394000
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 19 3.36e-02 -0.282000 0.264000
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 19 3.36e-02 -0.282000 0.264000
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 19 3.36e-02 -0.282000 0.264000
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 19 3.36e-02 -0.282000 0.264000
Impaired BRCA2 binding to PALB2 19 3.36e-02 -0.282000 0.264000
Cell junction organization 21 2.56e-02 0.281000 0.241000
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 25 1.51e-02 -0.281000 0.197000
HDR through Homologous Recombination (HRR) 55 3.38e-04 -0.280000 0.029600
LDL clearance 11 1.09e-01 -0.279000 0.428000
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 33 5.66e-03 -0.278000 0.130000
Diseases of DNA Double-Strand Break Repair 33 5.66e-03 -0.278000 0.130000
Pexophagy 11 1.12e-01 -0.277000 0.434000
HDR through Single Strand Annealing (SSA) 33 6.23e-03 -0.275000 0.133000
Homologous DNA Pairing and Strand Exchange 35 4.97e-03 -0.275000 0.124000
Caspase activation via extrinsic apoptotic signalling pathway 15 6.64e-02 -0.274000 0.360000
A tetrasaccharide linker sequence is required for GAG synthesis 10 1.35e-01 0.273000 0.463000
Removal of the Flap Intermediate 12 1.02e-01 -0.273000 0.418000
RNA Polymerase II Transcription Termination 38 3.72e-03 -0.272000 0.117000
Condensation of Prophase Chromosomes 12 1.03e-01 -0.272000 0.418000
GPCR ligand binding 68 1.15e-04 0.271000 0.019200
Removal of the Flap Intermediate from the C-strand 15 7.46e-02 -0.266000 0.368000
Synthesis of very long-chain fatty acyl-CoAs 10 1.50e-01 0.263000 0.485000
EGFR downregulation 20 4.36e-02 -0.261000 0.303000
Deposition of new CENPA-containing nucleosomes at the centromere 20 4.40e-02 -0.260000 0.303000
Nucleosome assembly 20 4.40e-02 -0.260000 0.303000
CD209 (DC-SIGN) signaling 15 8.12e-02 0.260000 0.384000
Gap-filling DNA repair synthesis and ligation in GG-NER 23 3.10e-02 -0.260000 0.261000
Collagen formation 18 5.70e-02 0.259000 0.338000
Stabilization of p53 46 2.48e-03 -0.258000 0.103000
RUNX2 regulates osteoblast differentiation 12 1.23e-01 0.258000 0.448000
Citric acid cycle (TCA cycle) 18 5.92e-02 -0.257000 0.342000
Rap1 signalling 11 1.40e-01 -0.257000 0.474000
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 15 8.69e-02 -0.255000 0.394000
Nucleotide catabolism 20 4.85e-02 -0.255000 0.321000
Translesion synthesis by POLK 15 8.80e-02 -0.255000 0.394000
Regulation of IFNG signaling 12 1.28e-01 0.254000 0.452000
VxPx cargo-targeting to cilium 16 7.87e-02 0.254000 0.380000
Recognition of DNA damage by PCNA-containing replication complex 26 2.55e-02 -0.253000 0.241000
SARS-CoV-2 modulates host translation machinery 38 7.44e-03 -0.251000 0.141000
RAC3 GTPase cycle 54 1.44e-03 0.251000 0.076300
Reproduction 43 4.45e-03 -0.251000 0.117000
Defects in vitamin and cofactor metabolism 16 8.33e-02 -0.250000 0.386000
STING mediated induction of host immune responses 10 1.71e-01 0.250000 0.516000
Processing of DNA double-strand break ends 51 2.15e-03 -0.249000 0.093200
DARPP-32 events 18 6.84e-02 0.248000 0.361000
Regulation of TP53 Activity through Phosphorylation 74 2.41e-04 -0.247000 0.024200
Plasma lipoprotein clearance 21 5.03e-02 -0.247000 0.321000
Regulation of TP53 Activity through Methylation 16 8.76e-02 -0.247000 0.394000
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 1.12e-01 0.245000 0.434000
AKT phosphorylates targets in the cytosol 13 1.26e-01 -0.245000 0.452000
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 77 2.29e-04 -0.243000 0.024200
Molecules associated with elastic fibres 10 1.84e-01 -0.243000 0.530000
VLDLR internalisation and degradation 11 1.64e-01 -0.242000 0.513000
Detoxification of Reactive Oxygen Species 22 4.99e-02 0.242000 0.321000
Hh mutants are degraded by ERAD 44 6.09e-03 -0.239000 0.133000
Hedgehog ligand biogenesis 48 4.21e-03 -0.239000 0.117000
Homology Directed Repair 83 1.84e-04 -0.238000 0.023900
Hh mutants abrogate ligand secretion 45 5.91e-03 -0.237000 0.133000
Integrin signaling 14 1.24e-01 -0.237000 0.450000
Platelet Aggregation (Plug Formation) 14 1.24e-01 -0.237000 0.450000
Autodegradation of the E3 ubiquitin ligase COP1 41 8.68e-03 -0.237000 0.156000
N-Glycan antennae elongation 11 1.75e-01 0.236000 0.519000
Negative regulation of FGFR1 signaling 17 9.27e-02 -0.236000 0.394000
Negative regulation of FGFR2 signaling 17 9.27e-02 -0.236000 0.394000
Negative regulation of FGFR3 signaling 17 9.27e-02 -0.236000 0.394000
Negative regulation of FGFR4 signaling 17 9.27e-02 -0.236000 0.394000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 1.98e-01 -0.235000 0.537000
alpha-linolenic acid (ALA) metabolism 10 1.98e-01 -0.235000 0.537000
G2/M DNA damage checkpoint 51 3.98e-03 -0.233000 0.117000
ER-Phagosome pathway 63 1.50e-03 -0.232000 0.076500
Class A/1 (Rhodopsin-like receptors) 40 1.14e-02 0.232000 0.162000
Cobalamin (Cbl, vitamin B12) transport and metabolism 10 2.06e-01 -0.231000 0.548000
mRNA decay by 3’ to 5’ exoribonuclease 14 1.38e-01 -0.229000 0.470000
Synthesis of PA 15 1.25e-01 0.229000 0.452000
Processive synthesis on the C-strand of the telomere 17 1.04e-01 -0.228000 0.421000
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 1.57e-01 -0.227000 0.496000
Nucleotide biosynthesis 12 1.75e-01 0.226000 0.519000
NOD1/2 Signaling Pathway 22 6.72e-02 -0.226000 0.360000
Regulation of pyruvate dehydrogenase (PDH) complex 10 2.18e-01 0.225000 0.553000
Signaling by KIT in disease 16 1.20e-01 0.225000 0.444000
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 1.20e-01 0.225000 0.444000
Regulation of TP53 Degradation 33 2.61e-02 -0.224000 0.241000
Regulation of TP53 Expression and Degradation 33 2.61e-02 -0.224000 0.241000
Lagging Strand Synthesis 17 1.10e-01 -0.224000 0.431000
Phase I - Functionalization of compounds 29 3.74e-02 0.223000 0.275000
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 6.55e-02 -0.222000 0.356000
RIP-mediated NFkB activation via ZBP1 13 1.67e-01 -0.222000 0.514000
Diseases associated with O-glycosylation of proteins 17 1.14e-01 0.221000 0.434000
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 31 3.31e-02 0.221000 0.264000
Translesion synthesis by REV1 14 1.53e-01 -0.221000 0.489000
Cardiac conduction 40 1.61e-02 0.220000 0.198000
Defective CFTR causes cystic fibrosis 49 7.90e-03 -0.220000 0.144000
Regulation of FZD by ubiquitination 12 1.92e-01 0.218000 0.534000
Formation of the ternary complex, and subsequently, the 43S complex 39 1.91e-02 -0.217000 0.215000
HDR through MMEJ (alt-NHEJ) 11 2.15e-01 -0.216000 0.551000
Glucagon-type ligand receptors 12 1.96e-01 0.216000 0.537000
G beta:gamma signalling through PLC beta 11 2.16e-01 0.216000 0.551000
Presynaptic function of Kainate receptors 11 2.16e-01 0.216000 0.551000
COPII-mediated vesicle transport 47 1.08e-02 -0.215000 0.160000
ER Quality Control Compartment (ERQC) 18 1.16e-01 -0.214000 0.437000
Hyaluronan metabolism 10 2.41e-01 -0.214000 0.579000
Diseases of DNA repair 41 1.80e-02 -0.214000 0.209000
p53-Dependent G1 DNA Damage Response 53 7.56e-03 -0.212000 0.141000
p53-Dependent G1/S DNA damage checkpoint 53 7.56e-03 -0.212000 0.141000
PCNA-Dependent Long Patch Base Excision Repair 18 1.20e-01 -0.212000 0.444000
Vif-mediated degradation of APOBEC3G 40 2.09e-02 -0.211000 0.219000
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 33 3.67e-02 -0.210000 0.273000
Peptide ligand-binding receptors 17 1.34e-01 0.210000 0.461000
Neurotransmitter release cycle 17 1.34e-01 0.210000 0.461000
DNA Double-Strand Break Repair 108 1.70e-04 -0.210000 0.023900
ZBP1(DAI) mediated induction of type I IFNs 16 1.46e-01 -0.210000 0.478000
Sensory processing of sound 23 8.21e-02 0.210000 0.384000
Sensory processing of sound by inner hair cells of the cochlea 23 8.21e-02 0.210000 0.384000
mRNA Splicing - Major Pathway 130 4.07e-05 -0.209000 0.011900
Spry regulation of FGF signaling 15 1.62e-01 -0.209000 0.508000
Chondroitin sulfate/dermatan sulfate metabolism 24 7.70e-02 0.209000 0.378000
ABC transporter disorders 55 7.59e-03 -0.208000 0.141000
G alpha (i) signalling events 81 1.25e-03 0.208000 0.069500
Signaling by PDGFR in disease 15 1.64e-01 0.208000 0.513000
Carboxyterminal post-translational modifications of tubulin 19 1.18e-01 0.207000 0.443000
Meiotic synapsis 22 9.30e-02 -0.207000 0.394000
G beta:gamma signalling through CDC42 11 2.39e-01 0.205000 0.579000
Purine salvage 10 2.64e-01 -0.204000 0.600000
Activation of NMDA receptors and postsynaptic events 42 2.23e-02 0.204000 0.223000
Downregulation of ERBB2:ERBB3 signaling 10 2.65e-01 -0.204000 0.600000
Translation initiation complex formation 45 1.82e-02 -0.204000 0.209000
Ephrin signaling 11 2.46e-01 0.202000 0.582000
PKMTs methylate histone lysines 23 9.41e-02 0.202000 0.397000
DNA Damage Bypass 40 2.75e-02 -0.202000 0.249000
Signaling by Retinoic Acid 17 1.51e-01 0.201000 0.486000
Telomere Extension By Telomerase 18 1.43e-01 -0.200000 0.474000
RAC2 GTPase cycle 52 1.29e-02 0.199000 0.176000
Nicotinamide salvaging 10 2.75e-01 0.199000 0.614000
Aggrephagy 19 1.33e-01 -0.199000 0.461000
AUF1 (hnRNP D0) binds and destabilizes mRNA 43 2.50e-02 -0.198000 0.239000
Ubiquitin-dependent degradation of Cyclin D 41 2.86e-02 -0.198000 0.257000
Constitutive Signaling by AKT1 E17K in Cancer 23 1.01e-01 -0.198000 0.415000
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 1.28e-01 -0.197000 0.452000
Disorders of Developmental Biology 10 2.84e-01 0.196000 0.614000
Disorders of Nervous System Development 10 2.84e-01 0.196000 0.614000
Loss of function of MECP2 in Rett syndrome 10 2.84e-01 0.196000 0.614000
Pervasive developmental disorders 10 2.84e-01 0.196000 0.614000
Signaling by Hippo 10 2.85e-01 0.195000 0.614000
Regulation of mRNA stability by proteins that bind AU-rich elements 72 4.22e-03 -0.195000 0.117000
RORA activates gene expression 11 2.62e-01 0.195000 0.599000
Degradation of cysteine and homocysteine 10 2.89e-01 -0.194000 0.614000
TRAF3-dependent IRF activation pathway 14 2.11e-01 0.193000 0.551000
Interleukin-35 Signalling 11 2.68e-01 0.193000 0.605000
Ion homeostasis 25 9.52e-02 0.193000 0.400000
HSF1 activation 21 1.27e-01 -0.192000 0.452000
Signaling by cytosolic FGFR1 fusion mutants 16 1.84e-01 0.192000 0.530000
Processing of Capped Intron-Containing Pre-mRNA 177 1.21e-05 -0.192000 0.004710
Neurexins and neuroligins 20 1.38e-01 0.191000 0.470000
Regulation of activated PAK-2p34 by proteasome mediated degradation 39 3.87e-02 -0.191000 0.276000
mRNA Splicing 138 1.12e-04 -0.191000 0.019200
Cleavage of the damaged pyrimidine 14 2.16e-01 -0.191000 0.551000
Depyrimidination 14 2.16e-01 -0.191000 0.551000
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 2.16e-01 -0.191000 0.551000
SUMOylation of immune response proteins 10 2.96e-01 0.191000 0.616000
ROS and RNS production in phagocytes 22 1.21e-01 0.191000 0.445000
Transport of Mature mRNA Derived from an Intronless Transcript 37 4.53e-02 -0.190000 0.308000
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 1.88e-01 0.190000 0.531000
Post NMDA receptor activation events 36 4.88e-02 0.190000 0.321000
Resolution of Sister Chromatid Cohesion 88 2.14e-03 -0.190000 0.093200
The role of GTSE1 in G2/M progression after G2 checkpoint 49 2.17e-02 -0.190000 0.223000
Resolution of Abasic Sites (AP sites) 32 6.35e-02 -0.190000 0.350000
RUNX2 regulates bone development 16 1.90e-01 0.189000 0.534000
Purine ribonucleoside monophosphate biosynthesis 10 3.00e-01 0.189000 0.619000
Processive synthesis on the lagging strand 13 2.40e-01 -0.188000 0.579000
Termination of translesion DNA synthesis 27 9.09e-02 -0.188000 0.394000
Sensory processing of sound by outer hair cells of the cochlea 14 2.24e-01 0.188000 0.558000
Regulation of HSF1-mediated heat shock response 63 1.01e-02 -0.188000 0.160000
NRIF signals cell death from the nucleus 13 2.44e-01 -0.187000 0.582000
DNA Double Strand Break Response 34 6.13e-02 -0.186000 0.343000
Signaling by NODAL 11 2.88e-01 0.185000 0.614000
Ion transport by P-type ATPases 27 9.67e-02 0.185000 0.404000
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 46 3.04e-02 -0.185000 0.261000
Chromosome Maintenance 71 7.28e-03 -0.185000 0.141000
Methylation 10 3.13e-01 -0.184000 0.630000
Transport of Mature Transcript to Cytoplasm 55 1.86e-02 -0.184000 0.211000
COPI-mediated anterograde transport 65 1.06e-02 -0.184000 0.160000
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 2.71e-01 -0.183000 0.610000
Antigen processing-Cross presentation 68 9.16e-03 -0.183000 0.158000
KSRP (KHSRP) binds and destabilizes mRNA 15 2.21e-01 -0.183000 0.557000
Attenuation phase 19 1.69e-01 -0.182000 0.514000
Inhibition of DNA recombination at telomere 18 1.81e-01 -0.182000 0.526000
Regulation of ornithine decarboxylase (ODC) 40 4.66e-02 -0.182000 0.313000
G1/S DNA Damage Checkpoints 55 2.02e-02 -0.181000 0.219000
BBSome-mediated cargo-targeting to cilium 16 2.15e-01 -0.179000 0.551000
Ribosomal scanning and start codon recognition 45 3.78e-02 -0.179000 0.276000
GABA receptor activation 16 2.17e-01 0.178000 0.553000
MicroRNA (miRNA) biogenesis 18 1.92e-01 -0.178000 0.534000
Platelet homeostasis 44 4.19e-02 0.177000 0.293000
TBC/RABGAPs 39 5.56e-02 -0.177000 0.337000
Other interleukin signaling 12 2.89e-01 0.177000 0.614000
Neurotransmitter receptors and postsynaptic signal transmission 72 9.58e-03 0.177000 0.160000
Glutamate Neurotransmitter Release Cycle 10 3.33e-01 0.177000 0.645000
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 16 2.22e-01 -0.176000 0.557000
Transport of Mature mRNAs Derived from Intronless Transcripts 38 6.03e-02 -0.176000 0.343000
Regulation of RUNX1 Expression and Activity 14 2.55e-01 -0.176000 0.589000
Pyruvate metabolism 18 1.97e-01 0.176000 0.537000
RUNX3 regulates p14-ARF 10 3.40e-01 -0.174000 0.649000
InlB-mediated entry of Listeria monocytogenes into host cell 11 3.18e-01 -0.174000 0.637000
Diseases associated with N-glycosylation of proteins 18 2.03e-01 -0.173000 0.543000
Netrin-1 signaling 24 1.43e-01 0.173000 0.474000
Vitamin B5 (pantothenate) metabolism 11 3.25e-01 -0.171000 0.643000
PRC2 methylates histones and DNA 11 3.26e-01 -0.171000 0.644000
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 33 8.96e-02 -0.171000 0.394000
Mitotic Prometaphase 147 3.83e-04 -0.170000 0.029800
RHO GTPases Activate Formins 97 3.84e-03 -0.170000 0.117000
Glycogen metabolism 17 2.25e-01 -0.170000 0.560000
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 3.08e-01 -0.170000 0.630000
Transmission across Chemical Synapses 91 5.31e-03 0.169000 0.129000
ADP signalling through P2Y purinoceptor 12 11 3.31e-01 0.169000 0.645000
Separation of Sister Chromatids 136 7.02e-04 -0.169000 0.048300
Neuronal System 124 1.22e-03 0.169000 0.069500
Downregulation of TGF-beta receptor signaling 25 1.44e-01 0.169000 0.477000
G2/M Checkpoints 106 2.77e-03 -0.169000 0.112000
activated TAK1 mediates p38 MAPK activation 12 3.12e-01 -0.168000 0.630000
Base Excision Repair 39 6.92e-02 -0.168000 0.361000
Translesion synthesis by POLI 15 2.59e-01 -0.168000 0.597000
Transport of Mature mRNA derived from an Intron-Containing Transcript 46 4.95e-02 -0.168000 0.321000
Degradation of DVL 45 5.25e-02 -0.167000 0.328000
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 31 1.08e-01 -0.167000 0.428000
rRNA modification in the nucleus and cytosol 44 5.56e-02 -0.167000 0.337000
Diseases of carbohydrate metabolism 23 1.67e-01 0.167000 0.514000
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 79 1.07e-02 -0.167000 0.160000
Amplification of signal from the kinetochores 79 1.07e-02 -0.167000 0.160000
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 2.51e-01 -0.166000 0.583000
ER to Golgi Anterograde Transport 99 4.62e-03 -0.165000 0.117000
Extension of Telomeres 40 7.17e-02 -0.165000 0.363000
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 43 6.21e-02 -0.165000 0.346000
RHOG GTPase cycle 44 5.92e-02 0.165000 0.342000
Telomere Maintenance 53 3.85e-02 -0.165000 0.276000
Nuclear Pore Complex (NPC) Disassembly 32 1.09e-01 -0.164000 0.428000
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 41 6.98e-02 -0.164000 0.361000
p53-Independent DNA Damage Response 41 6.98e-02 -0.164000 0.361000
p53-Independent G1/S DNA damage checkpoint 41 6.98e-02 -0.164000 0.361000
ADP signalling through P2Y purinoceptor 1 12 3.27e-01 0.163000 0.644000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 21 1.97e-01 0.163000 0.537000
Interleukin-1 signaling 72 1.74e-02 -0.162000 0.208000
Pausing and recovery of Tat-mediated HIV elongation 22 1.88e-01 -0.162000 0.531000
Tat-mediated HIV elongation arrest and recovery 22 1.88e-01 -0.162000 0.531000
Synthesis of glycosylphosphatidylinositol (GPI) 14 2.93e-01 -0.162000 0.616000
EML4 and NUDC in mitotic spindle formation 83 1.08e-02 -0.162000 0.160000
Defective pyroptosis 10 3.75e-01 -0.162000 0.664000
SCF(Skp2)-mediated degradation of p27/p21 49 5.07e-02 -0.162000 0.321000
Vpu mediated degradation of CD4 40 7.78e-02 -0.161000 0.380000
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 1.55e-01 0.161000 0.493000
Cytochrome P450 - arranged by substrate type 14 2.99e-01 0.160000 0.618000
Aquaporin-mediated transport 19 2.29e-01 0.160000 0.565000
Oncogene Induced Senescence 27 1.54e-01 -0.159000 0.491000
PI3K/AKT Signaling in Cancer 51 5.05e-02 -0.159000 0.321000
Complex I biogenesis 38 9.15e-02 -0.158000 0.394000
G beta:gamma signalling through PI3Kgamma 14 3.06e-01 0.158000 0.629000
TAK1-dependent IKK and NF-kappa-B activation 17 2.61e-01 -0.158000 0.598000
Cellular response to heat stress 76 1.80e-02 -0.157000 0.209000
HCMV Early Events 48 6.09e-02 -0.157000 0.343000
APC truncation mutants have impaired AXIN binding 12 3.48e-01 0.156000 0.652000
AXIN missense mutants destabilize the destruction complex 12 3.48e-01 0.156000 0.652000
Signaling by AMER1 mutants 12 3.48e-01 0.156000 0.652000
Signaling by APC mutants 12 3.48e-01 0.156000 0.652000
Signaling by AXIN mutants 12 3.48e-01 0.156000 0.652000
Truncations of AMER1 destabilize the destruction complex 12 3.48e-01 0.156000 0.652000
RAF activation 28 1.53e-01 0.156000 0.488000
Negative regulation of NOTCH4 signaling 45 7.00e-02 -0.156000 0.361000
Cell Cycle Checkpoints 208 1.12e-04 -0.156000 0.019200
Regulation of TNFR1 signaling 30 1.41e-01 -0.156000 0.474000
RHO GTPases Activate ROCKs 13 3.32e-01 -0.155000 0.645000
Heme signaling 25 1.79e-01 0.155000 0.523000
Calnexin/calreticulin cycle 23 1.97e-01 -0.155000 0.537000
HSF1-dependent transactivation 25 1.79e-01 -0.155000 0.523000
RAS processing 13 3.34e-01 0.155000 0.645000
Signaling by Activin 11 3.76e-01 0.154000 0.664000
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 49 6.30e-02 -0.154000 0.349000
Telomere C-strand (Lagging Strand) Synthesis 27 1.67e-01 -0.154000 0.514000
Viral Messenger RNA Synthesis 39 9.87e-02 -0.153000 0.410000
tRNA modification in the nucleus and cytosol 30 1.48e-01 -0.153000 0.482000
Export of Viral Ribonucleoproteins from Nucleus 29 1.56e-01 -0.152000 0.495000
Polymerase switching on the C-strand of the telomere 20 2.39e-01 -0.152000 0.579000
Arachidonic acid metabolism 19 2.51e-01 0.152000 0.583000
TNF signaling 35 1.20e-01 -0.152000 0.444000
Apoptotic factor-mediated response 14 3.25e-01 0.152000 0.643000
ISG15 antiviral mechanism 66 3.33e-02 -0.152000 0.264000
Nonhomologous End-Joining (NHEJ) 27 1.73e-01 -0.152000 0.517000
Degradation of GLI2 by the proteasome 47 7.35e-02 -0.151000 0.366000
GLI3 is processed to GLI3R by the proteasome 47 7.35e-02 -0.151000 0.366000
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 37 1.13e-01 -0.151000 0.434000
ABC-family proteins mediated transport 69 3.09e-02 -0.151000 0.261000
Class I peroxisomal membrane protein import 17 2.83e-01 -0.150000 0.614000
RND3 GTPase cycle 29 1.61e-01 0.150000 0.508000
NS1 Mediated Effects on Host Pathways 36 1.19e-01 -0.150000 0.444000
Degradation of GLI1 by the proteasome 48 7.31e-02 -0.150000 0.366000
AURKA Activation by TPX2 55 5.56e-02 -0.149000 0.337000
Metalloprotease DUBs 16 3.01e-01 -0.149000 0.620000
RAC1 GTPase cycle 99 1.07e-02 0.149000 0.160000
Cell-Cell communication 41 1.00e-01 0.148000 0.413000
Antiviral mechanism by IFN-stimulated genes 72 3.00e-02 -0.148000 0.261000
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 26 1.92e-01 -0.148000 0.534000
Regulation of Glucokinase by Glucokinase Regulatory Protein 26 1.92e-01 -0.148000 0.534000
Signaling by GPCR 187 5.27e-04 0.148000 0.038500
CDC42 GTPase cycle 88 1.69e-02 0.148000 0.203000
HIV elongation arrest and recovery 23 2.23e-01 -0.147000 0.557000
Pausing and recovery of HIV elongation 23 2.23e-01 -0.147000 0.557000
Basigin interactions 13 3.62e-01 0.146000 0.661000
Regulated Necrosis 41 1.06e-01 -0.146000 0.426000
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 74 3.03e-02 -0.146000 0.261000
tRNA processing in the nucleus 52 6.90e-02 -0.146000 0.361000
Interleukin-7 signaling 14 3.46e-01 0.146000 0.652000
Anchoring of the basal body to the plasma membrane 72 3.30e-02 -0.146000 0.264000
Interconversion of nucleotide di- and triphosphates 18 2.86e-01 0.145000 0.614000
Mitotic Prophase 70 3.63e-02 -0.145000 0.272000
Metabolism of non-coding RNA 45 9.29e-02 -0.145000 0.394000
snRNP Assembly 45 9.29e-02 -0.145000 0.394000
NIK–>noncanonical NF-kB signaling 46 9.02e-02 -0.145000 0.394000
Adrenaline,noradrenaline inhibits insulin secretion 12 3.86e-01 0.144000 0.673000
Signaling by NTRK3 (TRKC) 10 4.29e-01 0.144000 0.714000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 33 1.52e-01 0.144000 0.487000
SUMOylation of ubiquitinylation proteins 35 1.40e-01 -0.144000 0.474000
tRNA processing 86 2.12e-02 -0.144000 0.219000
Regulation of RUNX3 expression and activity 46 9.21e-02 -0.144000 0.394000
Respiratory electron transport 73 3.48e-02 -0.143000 0.268000
Beta-catenin phosphorylation cascade 15 3.39e-01 0.143000 0.649000
Intraflagellar transport 30 1.77e-01 -0.143000 0.521000
Transport of the SLBP independent Mature mRNA 30 1.78e-01 -0.142000 0.522000
Sensory Perception 61 5.55e-02 0.142000 0.337000
Metabolism of folate and pterines 11 4.16e-01 -0.142000 0.699000
Signaling by SCF-KIT 31 1.73e-01 0.141000 0.518000
SUMOylation of transcription cofactors 35 1.49e-01 0.141000 0.483000
Activation of GABAB receptors 15 3.45e-01 0.141000 0.652000
GABA B receptor activation 15 3.45e-01 0.141000 0.652000
Mitotic Spindle Checkpoint 91 2.06e-02 -0.141000 0.219000
Kinesins 31 1.77e-01 -0.140000 0.521000
Regulation of PLK1 Activity at G2/M Transition 67 4.73e-02 -0.140000 0.316000
TP53 Regulates Transcription of Cell Death Genes 29 1.91e-01 0.140000 0.534000
Regulation of PTEN stability and activity 52 8.06e-02 -0.140000 0.383000
SARS-CoV-2-host interactions 142 4.06e-03 -0.140000 0.117000
Infection with Mycobacterium tuberculosis 20 2.80e-01 -0.140000 0.614000
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 43 1.14e-01 -0.140000 0.434000
COPI-dependent Golgi-to-ER retrograde traffic 62 5.94e-02 -0.139000 0.342000
Regulation of TP53 Activity 128 6.96e-03 -0.139000 0.140000
DNA strand elongation 27 2.14e-01 -0.138000 0.551000
Disorders of transmembrane transporters 103 1.59e-02 -0.138000 0.197000
Uptake and actions of bacterial toxins 18 3.13e-01 0.137000 0.630000
Triglyceride catabolism 11 4.30e-01 0.137000 0.714000
Metabolism of RNA 509 1.78e-07 -0.137000 0.000208
E3 ubiquitin ligases ubiquitinate target proteins 40 1.36e-01 -0.136000 0.466000
Drug ADME 25 2.41e-01 0.136000 0.579000
RMTs methylate histone arginines 24 2.51e-01 0.135000 0.583000
XBP1(S) activates chaperone genes 39 1.45e-01 -0.135000 0.477000
HATs acetylate histones 53 9.02e-02 -0.135000 0.394000
Signaling by EGFR in Cancer 16 3.51e-01 -0.135000 0.654000
Synthesis of IP3 and IP4 in the cytosol 16 3.53e-01 0.134000 0.655000
Signaling by EGFR 35 1.70e-01 -0.134000 0.514000
APC/C:Cdc20 mediated degradation of mitotic proteins 58 7.85e-02 -0.134000 0.380000
Vpr-mediated nuclear import of PICs 30 2.05e-01 -0.134000 0.548000
GPCR downstream signalling 170 2.91e-03 0.133000 0.113000
UCH proteinases 69 5.66e-02 -0.133000 0.338000
Golgi-to-ER retrograde transport 90 3.00e-02 -0.133000 0.261000
Biological oxidations 73 5.07e-02 0.132000 0.321000
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 59 7.90e-02 -0.132000 0.380000
G alpha (z) signalling events 22 2.85e-01 0.132000 0.614000
Autodegradation of Cdh1 by Cdh1:APC/C 50 1.09e-01 -0.131000 0.428000
Signaling by FLT3 ITD and TKD mutants 12 4.32e-01 0.131000 0.716000
Intra-Golgi traffic 37 1.69e-01 -0.131000 0.514000
Transport of Ribonucleoproteins into the Host Nucleus 28 2.33e-01 -0.130000 0.572000
Intra-Golgi and retrograde Golgi-to-ER traffic 150 6.26e-03 -0.130000 0.133000
M Phase 273 2.48e-04 -0.130000 0.024200
Interleukin-1 family signaling 89 3.51e-02 -0.130000 0.268000
FGFR2 mutant receptor activation 16 3.71e-01 -0.129000 0.662000
Interleukin-2 family signaling 27 2.46e-01 0.129000 0.582000
Signaling by FGFR2 IIIa TM 15 3.87e-01 -0.129000 0.673000
DNA Damage Recognition in GG-NER 35 1.88e-01 -0.129000 0.531000
MAPK6/MAPK4 signaling 63 7.79e-02 -0.129000 0.380000
RHOQ GTPase cycle 36 1.83e-01 0.128000 0.529000
Interactions of Vpr with host cellular proteins 31 2.18e-01 -0.128000 0.553000
Signaling by FGFR2 47 1.29e-01 -0.128000 0.456000
Cross-presentation of soluble exogenous antigens (endosomes) 35 1.91e-01 -0.128000 0.534000
Cell Cycle 483 2.25e-06 -0.127000 0.001320
Regulation of IFNA/IFNB signaling 11 4.65e-01 0.127000 0.741000
Signaling by FGFR3 24 2.81e-01 -0.127000 0.614000
Signaling by FGFR4 24 2.81e-01 -0.127000 0.614000
Insulin processing 15 3.95e-01 0.127000 0.682000
Transport of the SLBP Dependant Mature mRNA 31 2.23e-01 -0.127000 0.557000
Glucagon signaling in metabolic regulation 14 4.13e-01 0.126000 0.699000
Ca2+ pathway 34 2.03e-01 0.126000 0.543000
Peroxisomal lipid metabolism 18 3.61e-01 -0.124000 0.661000
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.38e-01 -0.124000 0.718000
G alpha (q) signalling events 67 7.99e-02 0.124000 0.383000
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 57 1.06e-01 -0.124000 0.426000
RHO GTPase Effectors 182 4.27e-03 -0.123000 0.117000
Negative regulation of MET activity 14 4.24e-01 -0.123000 0.707000
RNA Polymerase II Pre-transcription Events 61 9.67e-02 -0.123000 0.404000
Retrograde transport at the Trans-Golgi-Network 42 1.68e-01 -0.123000 0.514000
Post-translational protein phosphorylation 32 2.28e-01 0.123000 0.565000
Vasopressin regulates renal water homeostasis via Aquaporins 18 3.67e-01 0.123000 0.661000
APC/C:Cdc20 mediated degradation of Securin 51 1.30e-01 -0.123000 0.456000
Heparan sulfate/heparin (HS-GAG) metabolism 22 3.20e-01 0.122000 0.640000
Dectin-1 mediated noncanonical NF-kB signaling 47 1.47e-01 -0.122000 0.480000
SUMOylation of SUMOylation proteins 30 2.46e-01 -0.122000 0.582000
Transport to the Golgi and subsequent modification 122 2.02e-02 -0.122000 0.219000
Recruitment of NuMA to mitotic centrosomes 59 1.05e-01 -0.122000 0.426000
NEP/NS2 Interacts with the Cellular Export Machinery 28 2.65e-01 -0.122000 0.600000
Interleukin receptor SHC signaling 15 4.15e-01 0.122000 0.699000
TICAM1-dependent activation of IRF3/IRF7 12 4.67e-01 -0.121000 0.741000
Transcriptional regulation by RUNX3 70 8.06e-02 -0.121000 0.383000
Cholesterol biosynthesis 20 3.50e-01 -0.121000 0.653000
O-linked glycosylation 36 2.10e-01 0.121000 0.551000
Fatty acyl-CoA biosynthesis 19 3.64e-01 0.120000 0.661000
Pyroptosis 17 3.91e-01 0.120000 0.677000
FOXO-mediated transcription 45 1.65e-01 0.120000 0.513000
Transport of bile salts and organic acids, metal ions and amine compounds 31 2.50e-01 0.119000 0.583000
Orc1 removal from chromatin 53 1.34e-01 -0.119000 0.461000
Regulation of Apoptosis 42 1.82e-01 -0.119000 0.527000
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 2.86e-01 -0.119000 0.614000
Clathrin-mediated endocytosis 82 6.44e-02 -0.118000 0.352000
Centrosome maturation 60 1.14e-01 -0.118000 0.434000
Recruitment of mitotic centrosome proteins and complexes 60 1.14e-01 -0.118000 0.434000
Protein-protein interactions at synapses 31 2.56e-01 0.118000 0.590000
Signaling by FGFR1 in disease 23 3.28e-01 0.118000 0.644000
Regulation of RUNX2 expression and activity 54 1.35e-01 -0.118000 0.463000
COPI-independent Golgi-to-ER retrograde traffic 28 2.81e-01 -0.118000 0.614000
Loss of Nlp from mitotic centrosomes 52 1.43e-01 -0.118000 0.474000
Loss of proteins required for interphase microtubule organization from the centrosome 52 1.43e-01 -0.118000 0.474000
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 56 1.29e-01 -0.118000 0.454000
Regulation of MECP2 expression and activity 20 3.64e-01 0.117000 0.661000
IRE1alpha activates chaperones 40 2.00e-01 -0.117000 0.539000
Smooth Muscle Contraction 19 3.77e-01 -0.117000 0.664000
mRNA Splicing - Minor Pathway 43 1.85e-01 -0.117000 0.530000
Maturation of nucleoprotein 11 5.05e-01 0.116000 0.758000
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 57 1.30e-01 -0.116000 0.456000
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 3.69e-01 0.116000 0.661000
Neurodegenerative Diseases 20 3.69e-01 0.116000 0.661000
Cilium Assembly 135 2.06e-02 -0.116000 0.219000
Cargo recognition for clathrin-mediated endocytosis 57 1.31e-01 -0.116000 0.457000
Rab regulation of trafficking 81 7.27e-02 -0.116000 0.366000
Synthesis of PIPs at the early endosome membrane 12 4.89e-01 -0.115000 0.751000
Regulation of expression of SLITs and ROBOs 118 3.18e-02 -0.115000 0.264000
rRNA processing 155 1.47e-02 -0.114000 0.195000
HCMV Late Events 47 1.77e-01 -0.114000 0.521000
Opioid Signalling 49 1.70e-01 0.114000 0.514000
SUMOylation of DNA methylation proteins 14 4.63e-01 0.113000 0.741000
mRNA decay by 5’ to 3’ exoribonuclease 14 4.64e-01 -0.113000 0.741000
DNA Repair 234 3.08e-03 -0.113000 0.116000
Major pathway of rRNA processing in the nucleolus and cytosol 145 2.06e-02 -0.112000 0.219000
G alpha (s) signalling events 38 2.33e-01 0.112000 0.572000
APC/C-mediated degradation of cell cycle proteins 70 1.07e-01 -0.112000 0.426000
Regulation of mitotic cell cycle 70 1.07e-01 -0.112000 0.426000
DNA Damage/Telomere Stress Induced Senescence 24 3.45e-01 -0.111000 0.652000
FGFR2 alternative splicing 22 3.66e-01 -0.111000 0.661000
Azathioprine ADME 15 4.55e-01 0.111000 0.736000
SCF-beta-TrCP mediated degradation of Emi1 44 2.03e-01 -0.111000 0.543000
Translation 228 4.14e-03 -0.111000 0.117000
Cell recruitment (pro-inflammatory response) 15 4.57e-01 0.111000 0.737000
Purinergic signaling in leishmaniasis infection 15 4.57e-01 0.111000 0.737000
Transcriptional regulation by small RNAs 41 2.20e-01 -0.111000 0.557000
HCMV Infection 67 1.18e-01 -0.111000 0.443000
CTNNB1 S33 mutants aren’t phosphorylated 13 4.91e-01 0.110000 0.751000
CTNNB1 S37 mutants aren’t phosphorylated 13 4.91e-01 0.110000 0.751000
CTNNB1 S45 mutants aren’t phosphorylated 13 4.91e-01 0.110000 0.751000
CTNNB1 T41 mutants aren’t phosphorylated 13 4.91e-01 0.110000 0.751000
Signaling by CTNNB1 phospho-site mutants 13 4.91e-01 0.110000 0.751000
Signaling by GSK3beta mutants 13 4.91e-01 0.110000 0.751000
RAB geranylgeranylation 37 2.47e-01 -0.110000 0.582000
Mitotic Metaphase and Anaphase 181 1.11e-02 -0.110000 0.161000
Peptide hormone metabolism 27 3.23e-01 0.110000 0.643000
G2/M Transition 145 2.30e-02 -0.110000 0.226000
PINK1-PRKN Mediated Mitophagy 19 4.09e-01 0.109000 0.697000
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 10 5.50e-01 -0.109000 0.793000
TP53 Regulates Transcription of DNA Repair Genes 45 2.07e-01 -0.109000 0.548000
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 4.82e-01 -0.109000 0.749000
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 4.82e-01 -0.109000 0.749000
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 5.52e-01 -0.109000 0.795000
RHOD GTPase cycle 32 2.89e-01 0.108000 0.614000
SUMOylation of RNA binding proteins 40 2.37e-01 -0.108000 0.579000
rRNA processing in the nucleus and cytosol 151 2.24e-02 -0.108000 0.223000
RHOJ GTPase cycle 34 2.76e-01 0.108000 0.614000
Mitotic G2-G2/M phases 147 2.44e-02 -0.108000 0.236000
Asparagine N-linked glycosylation 214 6.85e-03 -0.108000 0.140000
Lysosome Vesicle Biogenesis 24 3.62e-01 0.108000 0.661000
Mitotic Anaphase 180 1.34e-02 -0.107000 0.180000
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 3.44e-01 -0.107000 0.652000
FCERI mediated MAPK activation 21 3.96e-01 0.107000 0.682000
Pre-NOTCH Transcription and Translation 27 3.36e-01 -0.107000 0.647000
Metabolism of water-soluble vitamins and cofactors 76 1.08e-01 -0.107000 0.428000
Cell Cycle, Mitotic 390 3.55e-04 -0.107000 0.029600
Mismatch Repair 13 5.07e-01 -0.106000 0.760000
Unfolded Protein Response (UPR) 72 1.20e-01 -0.106000 0.444000
Signaling by FLT3 fusion proteins 15 4.78e-01 0.106000 0.748000
G1/S-Specific Transcription 23 3.80e-01 0.106000 0.667000
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 4.79e-01 -0.106000 0.748000
Fanconi Anemia Pathway 28 3.34e-01 -0.106000 0.645000
Activation of BH3-only proteins 25 3.61e-01 0.106000 0.661000
VEGFR2 mediated vascular permeability 21 4.05e-01 0.105000 0.693000
SUMOylation of intracellular receptors 19 4.29e-01 0.105000 0.714000
Signaling by NOTCH4 65 1.45e-01 -0.105000 0.477000
G-protein beta:gamma signalling 18 4.43e-01 0.105000 0.725000
TGF-beta receptor signaling activates SMADs 36 2.81e-01 0.104000 0.614000
Transport of vitamins, nucleosides, and related molecules 19 4.34e-01 0.104000 0.716000
Signaling by ROBO receptors 146 3.13e-02 -0.104000 0.261000
N-glycan antennae elongation in the medial/trans-Golgi 18 4.48e-01 0.103000 0.729000
Thrombin signalling through proteinase activated receptors (PARs) 16 4.74e-01 0.103000 0.748000
Dual Incision in GG-NER 34 2.98e-01 -0.103000 0.618000
Response of Mtb to phagocytosis 19 4.37e-01 -0.103000 0.718000
FGFR1 mutant receptor activation 19 4.38e-01 0.103000 0.718000
Signaling by FGFR 50 2.09e-01 -0.103000 0.550000
Cap-dependent Translation Initiation 91 9.16e-02 -0.103000 0.394000
Eukaryotic Translation Initiation 91 9.16e-02 -0.103000 0.394000
Cell surface interactions at the vascular wall 54 1.93e-01 0.102000 0.535000
Gap-filling DNA repair synthesis and ligation in TC-NER 54 1.95e-01 -0.102000 0.537000
Degradation of AXIN 44 2.42e-01 -0.102000 0.579000
Transcription of the HIV genome 50 2.13e-01 -0.102000 0.551000
Activation of NF-kappaB in B cells 53 2.01e-01 -0.102000 0.541000
Platelet calcium homeostasis 16 4.81e-01 0.102000 0.749000
Heme biosynthesis 10 5.78e-01 -0.102000 0.816000
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 3.55e-01 -0.101000 0.656000
Host Interactions of HIV factors 100 8.16e-02 -0.101000 0.384000
HIV Transcription Initiation 36 2.95e-01 -0.101000 0.616000
RNA Polymerase II HIV Promoter Escape 36 2.95e-01 -0.101000 0.616000
RNA Polymerase II Promoter Escape 36 2.95e-01 -0.101000 0.616000
RNA Polymerase II Transcription Initiation 36 2.95e-01 -0.101000 0.616000
RNA Polymerase II Transcription Initiation And Promoter Clearance 36 2.95e-01 -0.101000 0.616000
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 36 2.95e-01 -0.101000 0.616000
Diseases associated with the TLR signaling cascade 15 5.00e-01 -0.101000 0.755000
Diseases of Immune System 15 5.00e-01 -0.101000 0.755000
Signaling by BRAF and RAF1 fusions 41 2.65e-01 0.101000 0.600000
Visual phototransduction 31 3.34e-01 0.100000 0.645000
Retinoid metabolism and transport 10 5.83e-01 0.100000 0.817000
Formation of Incision Complex in GG-NER 35 3.06e-01 0.100000 0.628000
Deadenylation-dependent mRNA decay 50 2.23e-01 -0.099700 0.557000
ADORA2B mediated anti-inflammatory cytokines production 28 3.63e-01 0.099400 0.661000
CDK-mediated phosphorylation and removal of Cdc6 56 1.99e-01 -0.099300 0.539000
Assembly of the pre-replicative complex 64 1.70e-01 -0.099300 0.514000
Plasma lipoprotein assembly, remodeling, and clearance 35 3.10e-01 -0.099300 0.630000
Base-Excision Repair, AP Site Formation 16 4.92e-01 -0.099200 0.751000
SARS-CoV-2 Infection 203 1.57e-02 -0.098900 0.197000
MAP3K8 (TPL2)-dependent MAPK1/3 activation 13 5.38e-01 -0.098700 0.789000
Diseases associated with glycosaminoglycan metabolism 16 4.95e-01 0.098500 0.755000
ERK/MAPK targets 16 4.96e-01 -0.098300 0.755000
Degradation of the extracellular matrix 28 3.70e-01 0.098000 0.661000
Signaling by ERBB2 33 3.31e-01 -0.097800 0.645000
Interferon Signaling 130 5.59e-02 -0.097500 0.337000
Downstream signal transduction 20 4.51e-01 0.097400 0.733000
Abortive elongation of HIV-1 transcript in the absence of Tat 18 4.75e-01 -0.097200 0.748000
RNA Polymerase III Transcription Initiation 35 3.21e-01 -0.097000 0.640000
Collagen biosynthesis and modifying enzymes 13 5.46e-01 0.096800 0.791000
Thromboxane signalling through TP receptor 11 5.79e-01 0.096700 0.816000
PIP3 activates AKT signaling 172 2.97e-02 -0.096600 0.261000
Listeria monocytogenes entry into host cells 14 5.32e-01 -0.096500 0.784000
Interleukin-15 signaling 11 5.82e-01 0.095800 0.817000
SRP-dependent cotranslational protein targeting to membrane 86 1.26e-01 -0.095600 0.452000
Signaling by NOTCH1 51 2.39e-01 0.095400 0.579000
Activation of ATR in response to replication stress 29 3.76e-01 -0.095100 0.664000
Metabolism of polyamines 44 2.76e-01 -0.095000 0.614000
FCERI mediated NF-kB activation 59 2.08e-01 -0.094900 0.550000
CLEC7A (Dectin-1) signaling 77 1.52e-01 -0.094700 0.487000
The citric acid (TCA) cycle and respiratory electron transport 109 8.90e-02 -0.094600 0.394000
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 37 3.20e-01 -0.094500 0.640000
Inactivation of APC/C via direct inhibition of the APC/C complex 16 5.16e-01 0.093800 0.769000
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 16 5.16e-01 0.093800 0.769000
L13a-mediated translational silencing of Ceruloplasmin expression 83 1.41e-01 -0.093600 0.474000
SLC-mediated transmembrane transport 91 1.24e-01 0.093600 0.450000
Constitutive Signaling by Aberrant PI3K in Cancer 27 4.02e-01 -0.093300 0.690000
Nicotinate metabolism 16 5.20e-01 0.092900 0.774000
Oxidative Stress Induced Senescence 51 2.52e-01 -0.092800 0.584000
RHOBTB1 GTPase cycle 18 4.99e-01 0.092200 0.755000
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 5.81e-01 -0.092100 0.816000
Ca-dependent events 18 4.99e-01 0.092100 0.755000
Hedgehog ‘off’ state 70 1.84e-01 -0.091900 0.530000
Metabolism of cofactors 16 5.25e-01 0.091900 0.779000
RHO GTPases activate PKNs 26 4.20e-01 -0.091400 0.702000
NOTCH4 Intracellular Domain Regulates Transcription 14 5.54e-01 -0.091300 0.796000
Oncogenic MAPK signaling 54 2.48e-01 0.091100 0.583000
Gene Silencing by RNA 56 2.40e-01 -0.091000 0.579000
CaM pathway 17 5.16e-01 0.090900 0.769000
Calmodulin induced events 17 5.16e-01 0.090900 0.769000
Cellular response to hypoxia 56 2.42e-01 -0.090500 0.579000
Triglyceride metabolism 15 5.44e-01 0.090500 0.791000
Mitophagy 23 4.53e-01 0.090400 0.734000
PTEN Regulation 104 1.12e-01 -0.090400 0.434000
Formation of a pool of free 40S subunits 75 1.79e-01 -0.089900 0.523000
Suppression of phagosomal maturation 11 6.06e-01 -0.089900 0.828000
Influenza Infection 126 8.28e-02 -0.089800 0.386000
Nuclear Envelope Breakdown 45 2.99e-01 -0.089600 0.618000
Regulation of RAS by GAPs 52 2.65e-01 -0.089400 0.600000
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 15 5.50e-01 -0.089200 0.793000
Depolymerisation of the Nuclear Lamina 11 6.10e-01 0.088800 0.830000
RAF-independent MAPK1/3 activation 19 5.03e-01 0.088800 0.758000
Early Phase of HIV Life Cycle 12 5.97e-01 -0.088300 0.825000
Nuclear import of Rev protein 29 4.11e-01 -0.088200 0.698000
Synthesis of DNA 93 1.43e-01 -0.088100 0.474000
FLT3 signaling in disease 23 4.65e-01 -0.088100 0.741000
Organelle biogenesis and maintenance 187 3.94e-02 -0.087800 0.279000
Influenza Viral RNA Transcription and Replication 109 1.14e-01 -0.087800 0.434000
RND1 GTPase cycle 29 4.14e-01 0.087700 0.699000
DNA Replication Pre-Initiation 77 1.86e-01 -0.087400 0.530000
Downstream TCR signaling 64 2.28e-01 -0.087200 0.565000
TRAF6 mediated IRF7 activation 16 5.47e-01 0.087100 0.791000
Transport of inorganic cations/anions and amino acids/oligopeptides 38 3.54e-01 0.086900 0.656000
RHOV GTPase cycle 25 4.53e-01 0.086700 0.734000
SUMOylation of DNA damage response and repair proteins 64 2.31e-01 -0.086600 0.571000
Metabolic disorders of biological oxidation enzymes 13 5.89e-01 0.086600 0.819000
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 6.04e-01 -0.086400 0.828000
GTP hydrolysis and joining of the 60S ribosomal subunit 84 1.73e-01 -0.086300 0.517000
Toll Like Receptor 4 (TLR4) Cascade 86 1.68e-01 -0.086200 0.514000
MyD88-independent TLR4 cascade 71 2.13e-01 -0.085700 0.551000
TRIF(TICAM1)-mediated TLR4 signaling 71 2.13e-01 -0.085700 0.551000
Anti-inflammatory response favouring Leishmania parasite infection 47 3.10e-01 0.085600 0.630000
Leishmania parasite growth and survival 47 3.10e-01 0.085600 0.630000
RET signaling 22 4.87e-01 0.085600 0.751000
CTLA4 inhibitory signaling 15 5.66e-01 0.085600 0.807000
Regulation of APC/C activators between G1/S and early anaphase 64 2.38e-01 -0.085400 0.579000
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 61 2.51e-01 -0.085200 0.583000
Death Receptor Signalling 86 1.74e-01 -0.085000 0.518000
Muscle contraction 63 2.47e-01 0.084400 0.583000
Ovarian tumor domain proteases 29 4.32e-01 -0.084300 0.716000
Signaling by RAF1 mutants 25 4.68e-01 0.084000 0.741000
SUMOylation of DNA replication proteins 41 3.53e-01 -0.083900 0.655000
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 13 6.01e-01 0.083900 0.827000
TP53 Regulates Metabolic Genes 61 2.60e-01 -0.083500 0.597000
Mitochondrial protein import 40 3.65e-01 -0.082900 0.661000
Cyclin A/B1/B2 associated events during G2/M transition 22 5.04e-01 -0.082400 0.758000
Metabolism of steroid hormones 13 6.07e-01 -0.082400 0.828000
Formation of RNA Pol II elongation complex 45 3.40e-01 -0.082300 0.649000
RNA Polymerase II Transcription Elongation 45 3.40e-01 -0.082300 0.649000
RNA Polymerase III Abortive And Retractive Initiation 38 3.83e-01 -0.081900 0.669000
RNA Polymerase III Transcription 38 3.83e-01 -0.081900 0.669000
Nuclear signaling by ERBB4 14 5.96e-01 0.081900 0.825000
L1CAM interactions 34 4.11e-01 0.081500 0.698000
APC/C:Cdc20 mediated degradation of Cyclin B 19 5.40e-01 -0.081300 0.791000
SARS-CoV Infections 257 2.62e-02 -0.081100 0.241000
MAP kinase activation 46 3.42e-01 -0.081100 0.651000
Signaling by NOTCH2 18 5.53e-01 -0.080900 0.795000
Bile acid and bile salt metabolism 13 6.14e-01 0.080800 0.833000
Signaling by FGFR1 27 4.68e-01 -0.080800 0.741000
RHOBTB2 GTPase cycle 19 5.44e-01 -0.080400 0.791000
DNA Replication 100 1.66e-01 -0.080400 0.514000
Gap junction trafficking and regulation 10 6.62e-01 0.079900 0.863000
RUNX1 regulates transcription of genes involved in differentiation of HSCs 53 3.16e-01 -0.079700 0.635000
NOTCH1 Intracellular Domain Regulates Transcription 37 4.03e-01 0.079500 0.691000
Extracellular matrix organization 73 2.44e-01 0.079000 0.582000
Intracellular signaling by second messengers 194 5.97e-02 -0.078800 0.342000
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 6.67e-01 -0.078600 0.863000
Intrinsic Pathway for Apoptosis 43 3.73e-01 0.078600 0.664000
TNFR1-induced NFkappaB signaling pathway 19 5.56e-01 -0.078000 0.797000
Costimulation by the CD28 family 41 3.88e-01 0.077900 0.674000
Aberrant regulation of mitotic exit in cancer due to RB1 defects 15 6.02e-01 0.077800 0.827000
Non-integrin membrane-ECM interactions 11 6.56e-01 0.077500 0.858000
Activation of HOX genes during differentiation 37 4.17e-01 -0.077300 0.699000
Activation of anterior HOX genes in hindbrain development during early embryogenesis 37 4.17e-01 -0.077300 0.699000
Mitochondrial iron-sulfur cluster biogenesis 12 6.44e-01 -0.077200 0.855000
Nuclear Events (kinase and transcription factor activation) 42 3.88e-01 -0.077100 0.673000
Transcriptional Regulation by TP53 272 3.00e-02 -0.077000 0.261000
Pre-NOTCH Processing in Golgi 15 6.06e-01 0.076900 0.828000
Glucose metabolism 68 2.77e-01 -0.076400 0.614000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 59 3.12e-01 -0.076200 0.630000
Signaling by ERBB4 29 4.78e-01 0.076100 0.748000
RHOBTB GTPase Cycle 28 4.87e-01 -0.075900 0.751000
Gluconeogenesis 23 5.30e-01 -0.075700 0.784000
Polo-like kinase mediated events 16 6.01e-01 0.075600 0.827000
Regulation of innate immune responses to cytosolic DNA 11 6.64e-01 -0.075600 0.863000
Apoptotic execution phase 30 4.76e-01 -0.075300 0.748000
Ion channel transport 76 2.62e-01 0.074500 0.599000
Translocation of SLC2A4 (GLUT4) to the plasma membrane 44 3.95e-01 0.074100 0.682000
Signaling by ERBB2 KD Mutants 12 6.58e-01 0.073900 0.859000
Protein methylation 10 6.86e-01 -0.073700 0.877000
SARS-CoV-2 activates/modulates innate and adaptive immune responses 82 2.50e-01 -0.073600 0.583000
Circadian Clock 51 3.64e-01 0.073500 0.661000
Toll Like Receptor 9 (TLR9) Cascade 64 3.10e-01 -0.073500 0.630000
Zinc transporters 11 6.73e-01 -0.073500 0.867000
Growth hormone receptor signaling 16 6.11e-01 0.073500 0.831000
Vesicle-mediated transport 416 1.12e-02 -0.073400 0.161000
Regulation of BACH1 activity 11 6.74e-01 0.073300 0.867000
NR1H2 and NR1H3-mediated signaling 24 5.35e-01 0.073300 0.786000
Protein localization 110 1.86e-01 -0.073200 0.530000
Fatty acid metabolism 90 2.33e-01 0.072900 0.572000
Peroxisomal protein import 44 4.07e-01 -0.072300 0.695000
Toll Like Receptor 3 (TLR3) Cascade 71 2.94e-01 -0.072100 0.616000
MyD88 dependent cascade initiated on endosome 62 3.28e-01 -0.071900 0.644000
Toll Like Receptor 7/8 (TLR7/8) Cascade 62 3.28e-01 -0.071900 0.644000
Signaling by PDGF 24 5.43e-01 0.071800 0.791000
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 18 5.99e-01 0.071700 0.827000
Regulation of PTEN gene transcription 44 4.11e-01 -0.071600 0.698000
TP53 Regulates Transcription of Cell Cycle Genes 40 4.34e-01 -0.071600 0.716000
Josephin domain DUBs 11 6.83e-01 -0.071100 0.875000
Amino acids regulate mTORC1 35 4.68e-01 -0.070900 0.741000
Deactivation of the beta-catenin transactivating complex 26 5.32e-01 -0.070900 0.784000
PPARA activates gene expression 79 2.78e-01 0.070700 0.614000
SARS-CoV-1 Infection 44 4.19e-01 -0.070500 0.701000
Metabolism of fat-soluble vitamins 12 6.73e-01 0.070400 0.867000
Integration of energy metabolism 52 3.82e-01 0.070100 0.669000
RNA polymerase II transcribes snRNA genes 65 3.31e-01 -0.069900 0.645000
DCC mediated attractive signaling 11 6.89e-01 0.069800 0.877000
Membrane Trafficking 409 1.68e-02 -0.069700 0.203000
MAPK targets/ Nuclear events mediated by MAP kinases 22 5.72e-01 -0.069600 0.813000
MET promotes cell motility 11 6.89e-01 0.069600 0.877000
PERK regulates gene expression 26 5.42e-01 -0.069200 0.791000
GPVI-mediated activation cascade 21 5.84e-01 -0.069000 0.817000
Switching of origins to a post-replicative state 69 3.24e-01 -0.068800 0.643000
Peptide chain elongation 67 3.32e-01 -0.068700 0.645000
Signaling by CSF3 (G-CSF) 23 5.71e-01 -0.068300 0.813000
Interactions of Rev with host cellular proteins 32 5.05e-01 -0.068200 0.758000
HIV Infection 175 1.22e-01 -0.068200 0.446000
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 84 2.83e-01 -0.067900 0.614000
Nonsense-Mediated Decay (NMD) 84 2.83e-01 -0.067900 0.614000
The role of Nef in HIV-1 replication and disease pathogenesis 18 6.22e-01 0.067200 0.840000
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 5.47e-01 -0.067100 0.791000
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 7.01e-01 0.066900 0.881000
FOXO-mediated transcription of cell cycle genes 12 6.90e-01 0.066600 0.877000
Interferon alpha/beta signaling 46 4.36e-01 -0.066400 0.718000
Cyclin A:Cdk2-associated events at S phase entry 70 3.39e-01 -0.066200 0.649000
MyD88 cascade initiated on plasma membrane 61 3.74e-01 -0.065900 0.664000
Toll Like Receptor 10 (TLR10) Cascade 61 3.74e-01 -0.065900 0.664000
Toll Like Receptor 5 (TLR5) Cascade 61 3.74e-01 -0.065900 0.664000
Response of EIF2AK1 (HRI) to heme deficiency 13 6.81e-01 0.065800 0.874000
Nucleotide salvage 17 6.39e-01 -0.065700 0.854000
Metabolism of steroids 80 3.12e-01 -0.065600 0.630000
RNA Polymerase I Promoter Escape 26 5.63e-01 0.065500 0.804000
RND2 GTPase cycle 33 5.15e-01 0.065500 0.769000
Cyclin E associated events during G1/S transition 68 3.52e-01 -0.065400 0.655000
S Phase 127 2.07e-01 -0.065100 0.548000
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 21 6.06e-01 0.065000 0.828000
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 64 3.69e-01 -0.065000 0.661000
Toll Like Receptor 2 (TLR2) Cascade 64 3.69e-01 -0.065000 0.661000
Toll Like Receptor TLR1:TLR2 Cascade 64 3.69e-01 -0.065000 0.661000
Toll Like Receptor TLR6:TLR2 Cascade 64 3.69e-01 -0.065000 0.661000
Dual incision in TC-NER 55 4.06e-01 -0.064900 0.694000
Apoptosis 124 2.15e-01 -0.064700 0.551000
Toll-like Receptor Cascades 96 2.77e-01 -0.064400 0.614000
Metabolism of nitric oxide: NOS3 activation and regulation 12 7.01e-01 0.064000 0.881000
Signaling by Hedgehog 93 2.90e-01 -0.063700 0.614000
Signaling by ALK 17 6.51e-01 0.063400 0.856000
Synthesis of substrates in N-glycan biosythesis 46 4.58e-01 -0.063300 0.737000
G1/S Transition 103 2.68e-01 -0.063300 0.605000
Signaling by ALK fusions and activated point mutants 42 4.79e-01 -0.063200 0.748000
Signaling by ALK in cancer 42 4.79e-01 -0.063200 0.748000
Programmed Cell Death 144 1.94e-01 -0.063000 0.535000
Metabolism of vitamins and cofactors 103 2.72e-01 -0.062800 0.611000
Insulin receptor signalling cascade 23 6.03e-01 -0.062800 0.827000
RNA Polymerase I Transcription Termination 24 5.96e-01 0.062600 0.825000
Nucleotide Excision Repair 98 2.86e-01 -0.062600 0.614000
Regulation of lipid metabolism by PPARalpha 81 3.31e-01 0.062600 0.645000
B-WICH complex positively regulates rRNA expression 27 5.79e-01 0.061700 0.816000
Regulation of KIT signaling 10 7.36e-01 0.061500 0.898000
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 49 4.58e-01 -0.061400 0.737000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 19 6.44e-01 0.061200 0.855000
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 14 6.92e-01 0.061100 0.877000
PI3K Cascade 17 6.63e-01 -0.061000 0.863000
Diseases associated with glycosylation precursor biosynthesis 15 6.83e-01 -0.061000 0.875000
p75 NTR receptor-mediated signalling 53 4.45e-01 -0.060800 0.726000
Cellular Senescence 99 3.00e-01 -0.060400 0.619000
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 20 6.40e-01 0.060400 0.855000
SUMO E3 ligases SUMOylate target proteins 127 2.42e-01 -0.060300 0.579000
Eukaryotic Translation Elongation 70 3.84e-01 -0.060300 0.670000
NGF-stimulated transcription 25 6.02e-01 -0.060200 0.827000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 23 6.17e-01 0.060200 0.835000
RHOF GTPase cycle 22 6.30e-01 0.059300 0.848000
Global Genome Nucleotide Excision Repair (GG-NER) 75 3.76e-01 -0.059200 0.664000
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 5.87e-01 0.058400 0.817000
Signaling by RAS mutants 29 5.87e-01 0.058400 0.817000
Signaling by moderate kinase activity BRAF mutants 29 5.87e-01 0.058400 0.817000
Signaling downstream of RAS mutants 29 5.87e-01 0.058400 0.817000
RHO GTPases Activate WASPs and WAVEs 28 5.95e-01 -0.058100 0.825000
trans-Golgi Network Vesicle Budding 50 4.78e-01 -0.058100 0.748000
Recycling pathway of L1 15 6.98e-01 0.057900 0.880000
Eukaryotic Translation Termination 70 4.03e-01 -0.057900 0.691000
EPHB-mediated forward signaling 25 6.17e-01 -0.057800 0.835000
RHO GTPases activate PAKs 13 7.19e-01 -0.057700 0.897000
Late Phase of HIV Life Cycle 106 3.08e-01 -0.057500 0.630000
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 18 6.75e-01 -0.057100 0.867000
Integrin cell surface interactions 22 6.43e-01 0.057100 0.855000
Nephrin family interactions 12 7.33e-01 0.056900 0.898000
HIV Life Cycle 117 2.90e-01 -0.056800 0.614000
C-type lectin receptors (CLRs) 92 3.55e-01 -0.055900 0.656000
RHOH GTPase cycle 25 6.29e-01 0.055800 0.848000
GPER1 signaling 20 6.66e-01 0.055700 0.863000
SLC transporter disorders 48 5.05e-01 -0.055700 0.758000
Synthesis of PIPs at the plasma membrane 34 5.77e-01 0.055300 0.816000
mTORC1-mediated signalling 17 6.93e-01 -0.055300 0.877000
Cellular response to starvation 110 3.21e-01 -0.054900 0.640000
Fcgamma receptor (FCGR) dependent phagocytosis 59 4.67e-01 -0.054800 0.741000
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 7.45e-01 0.054300 0.898000
Trafficking of AMPA receptors 12 7.45e-01 0.054300 0.898000
Cellular responses to stimuli 513 3.83e-02 -0.054200 0.276000
Negative regulation of the PI3K/AKT network 54 4.92e-01 -0.054200 0.751000
Gamma carboxylation, hypusine formation and arylsulfatase activation 21 6.68e-01 0.054100 0.863000
Protein ubiquitination 56 4.91e-01 -0.053300 0.751000
Viral mRNA Translation 67 4.53e-01 -0.053100 0.734000
Cargo concentration in the ER 18 6.97e-01 -0.053100 0.879000
G0 and Early G1 24 6.54e-01 0.052900 0.856000
NOTCH3 Intracellular Domain Regulates Transcription 15 7.23e-01 0.052800 0.897000
Cellular responses to stress 509 4.46e-02 -0.052800 0.305000
Glycosaminoglycan metabolism 60 4.82e-01 0.052500 0.749000
Amino acid transport across the plasma membrane 15 7.26e-01 0.052300 0.897000
DAG and IP3 signaling 23 6.65e-01 0.052100 0.863000
Role of phospholipids in phagocytosis 14 7.37e-01 -0.051900 0.898000
Branched-chain amino acid catabolism 20 6.89e-01 -0.051800 0.877000
SUMOylation of transcription factors 13 7.47e-01 0.051800 0.898000
Signaling by TGFB family members 81 4.22e-01 0.051700 0.705000
Transcriptional regulation of granulopoiesis 23 6.68e-01 0.051700 0.863000
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 68 4.64e-01 -0.051500 0.741000
Regulation of cholesterol biosynthesis by SREBP (SREBF) 46 5.48e-01 -0.051200 0.792000
Infectious disease 591 3.70e-02 -0.051100 0.274000
Sealing of the nuclear envelope (NE) by ESCRT-III 16 7.25e-01 0.050800 0.897000
TNFR1-induced proapoptotic signaling 12 7.62e-01 -0.050600 0.905000
Rev-mediated nuclear export of HIV RNA 31 6.29e-01 -0.050200 0.848000
Sema3A PAK dependent Axon repulsion 10 7.84e-01 -0.050100 0.917000
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 12 7.64e-01 -0.050000 0.905000
Phase II - Conjugation of compounds 41 5.81e-01 0.049900 0.816000
Selenocysteine synthesis 68 4.79e-01 -0.049800 0.748000
RHO GTPase cycle 269 1.67e-01 0.049400 0.514000
Translation of Replicase and Assembly of the Replication Transcription Complex 10 7.87e-01 0.049300 0.919000
Degradation of beta-catenin by the destruction complex 64 4.96e-01 -0.049300 0.755000
Estrogen-dependent gene expression 67 4.91e-01 -0.048700 0.751000
Mitotic G1 phase and G1/S transition 118 3.64e-01 -0.048500 0.661000
Aberrant regulation of mitotic cell cycle due to RB1 defects 29 6.52e-01 0.048300 0.856000
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 15 7.47e-01 0.048200 0.898000
Prefoldin mediated transfer of substrate to CCT/TriC 16 7.41e-01 -0.047700 0.898000
Defective Intrinsic Pathway for Apoptosis 23 6.92e-01 0.047700 0.877000
Interleukin-12 signaling 35 6.30e-01 -0.047100 0.848000
RAB GEFs exchange GTP for GDP on RABs 52 5.58e-01 -0.047100 0.798000
Response of EIF2AK4 (GCN2) to amino acid deficiency 75 4.83e-01 -0.047000 0.749000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 31 6.53e-01 -0.046700 0.856000
Translation of Structural Proteins 27 6.85e-01 -0.045200 0.876000
Energy dependent regulation of mTOR by LKB1-AMPK 21 7.21e-01 0.045000 0.897000
PCP/CE pathway 68 5.30e-01 -0.044200 0.784000
RNA Polymerase I Transcription Initiation 39 6.34e-01 0.044100 0.851000
Downstream signaling events of B Cell Receptor (BCR) 66 5.37e-01 -0.044000 0.789000
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 7.16e-01 -0.043800 0.896000
DAP12 interactions 19 7.42e-01 -0.043700 0.898000
EGR2 and SOX10-mediated initiation of Schwann cell myelination 11 8.03e-01 0.043600 0.929000
Formation of tubulin folding intermediates by CCT/TriC 13 7.87e-01 -0.043200 0.919000
Regulation of signaling by CBL 13 7.89e-01 0.042900 0.920000
IGF1R signaling cascade 21 7.34e-01 -0.042900 0.898000
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 21 7.34e-01 -0.042900 0.898000
Cyclin D associated events in G1 40 6.42e-01 0.042500 0.855000
G1 Phase 40 6.42e-01 0.042500 0.855000
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 5.34e-01 -0.042500 0.786000
Signaling by ERBB2 TMD/JMD mutants 10 8.16e-01 0.042400 0.934000
Interleukin-3, Interleukin-5 and GM-CSF signaling 28 6.99e-01 0.042300 0.880000
Regulation of actin dynamics for phagocytic cup formation 42 6.36e-01 -0.042300 0.851000
Activation of gene expression by SREBF (SREBP) 34 6.70e-01 -0.042200 0.865000
Asymmetric localization of PCP proteins 49 6.10e-01 -0.042200 0.830000
Regulation of beta-cell development 15 7.77e-01 0.042200 0.913000
Gene expression (Transcription) 941 3.40e-02 -0.042000 0.265000
TRAF6 mediated NF-kB activation 19 7.55e-01 -0.041400 0.903000
Antigen processing: Ubiquitination & Proteasome degradation 224 2.90e-01 0.041300 0.614000
Transcriptional regulation by RUNX2 78 5.30e-01 -0.041200 0.784000
ERKs are inactivated 11 8.14e-01 0.041000 0.933000
Transcription of E2F targets under negative control by DREAM complex 17 7.71e-01 0.040800 0.909000
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 6.54e-01 0.040500 0.856000
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 6.54e-01 0.040500 0.856000
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 6.54e-01 0.040500 0.856000
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 6.54e-01 0.040500 0.856000
Signaling by NOTCH1 in Cancer 41 6.54e-01 0.040500 0.856000
ATF4 activates genes in response to endoplasmic reticulum stress 23 7.40e-01 -0.040000 0.898000
Signaling by ERBB2 ECD mutants 10 8.27e-01 0.039900 0.935000
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 19 7.64e-01 0.039800 0.905000
RNA Polymerase III Chain Elongation 17 7.77e-01 -0.039700 0.913000
Transcriptional regulation by RUNX1 118 4.68e-01 0.038800 0.741000
SUMOylation 132 4.44e-01 -0.038700 0.726000
Cytoprotection by HMOX1 42 6.65e-01 0.038700 0.863000
CLEC7A (Dectin-1) induces NFAT activation 11 8.24e-01 -0.038600 0.935000
Cytokine Signaling in Immune system 392 1.96e-01 -0.038500 0.537000
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 7.40e-01 -0.038300 0.898000
APC-Cdc20 mediated degradation of Nek2A 21 7.62e-01 -0.038200 0.905000
Amyloid fiber formation 25 7.42e-01 -0.038000 0.898000
CD28 dependent PI3K/Akt signaling 18 7.82e-01 -0.037700 0.916000
FCERI mediated Ca+2 mobilization 22 7.60e-01 0.037600 0.905000
Disease 1022 5.03e-02 -0.037300 0.321000
Association of TriC/CCT with target proteins during biosynthesis 29 7.28e-01 -0.037300 0.897000
RNA Polymerase II Transcription 835 7.47e-02 -0.037200 0.368000
Signaling by WNT 165 4.13e-01 0.037100 0.699000
Sema4D induced cell migration and growth-cone collapse 11 8.33e-01 0.036700 0.938000
Glyoxylate metabolism and glycine degradation 19 7.82e-01 -0.036700 0.916000
Macroautophagy 85 5.62e-01 0.036400 0.804000
Cleavage of the damaged purine 10 8.42e-01 0.036300 0.938000
Depurination 10 8.42e-01 0.036300 0.938000
Recognition and association of DNA glycosylase with site containing an affected purine 10 8.42e-01 0.036300 0.938000
Diseases of signal transduction by growth factor receptors and second messengers 284 2.97e-01 -0.036300 0.617000
Formation of HIV-1 elongation complex containing HIV-1 Tat 31 7.27e-01 -0.036300 0.897000
HIV Transcription Elongation 31 7.27e-01 -0.036300 0.897000
Tat-mediated elongation of the HIV-1 transcript 31 7.27e-01 -0.036300 0.897000
Autophagy 93 5.47e-01 0.036200 0.791000
Platelet sensitization by LDL 13 8.22e-01 0.036100 0.935000
Nuclear Receptor transcription pathway 26 7.51e-01 -0.036000 0.900000
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 8.16e-01 0.036000 0.934000
HDACs deacetylate histones 28 7.43e-01 -0.035800 0.898000
Mitochondrial translation 84 5.72e-01 -0.035700 0.813000
PIWI-interacting RNA (piRNA) biogenesis 15 8.11e-01 -0.035600 0.933000
RNA Pol II CTD phosphorylation and interaction with CE 23 7.68e-01 -0.035500 0.907000
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 23 7.68e-01 -0.035500 0.907000
Adaptive Immune System 439 2.08e-01 0.035500 0.550000
G alpha (12/13) signalling events 33 7.25e-01 0.035500 0.897000
Nuclear events stimulated by ALK signaling in cancer 13 8.25e-01 0.035400 0.935000
Inactivation, recovery and regulation of the phototransduction cascade 16 8.08e-01 0.035200 0.931000
The phototransduction cascade 16 8.08e-01 0.035200 0.931000
Metabolism of amino acids and derivatives 214 3.79e-01 -0.035100 0.666000
Signalling to ERKs 25 7.64e-01 0.034700 0.905000
Frs2-mediated activation 11 8.42e-01 -0.034700 0.938000
FCGR3A-mediated phagocytosis 40 7.06e-01 -0.034500 0.884000
Leishmania phagocytosis 40 7.06e-01 -0.034500 0.884000
Parasite infection 40 7.06e-01 -0.034500 0.884000
Signal Transduction 1254 5.04e-02 0.034100 0.321000
Cargo trafficking to the periciliary membrane 37 7.20e-01 -0.034000 0.897000
Membrane binding and targetting of GAG proteins 11 8.45e-01 -0.034000 0.938000
Synthesis And Processing Of GAG, GAGPOL Polyproteins 11 8.45e-01 -0.034000 0.938000
RHOC GTPase cycle 45 6.95e-01 0.033800 0.879000
Endosomal Sorting Complex Required For Transport (ESCRT) 25 7.72e-01 -0.033500 0.910000
Platelet activation, signaling and aggregation 120 5.29e-01 -0.033400 0.784000
Positive epigenetic regulation of rRNA expression 40 7.19e-01 0.032900 0.897000
Diseases of programmed cell death 37 7.29e-01 -0.032900 0.897000
G-protein mediated events 27 7.68e-01 -0.032900 0.907000
Insulin receptor recycling 17 8.16e-01 0.032700 0.934000
Sialic acid metabolism 22 7.92e-01 0.032500 0.922000
Signaling by Receptor Tyrosine Kinases 279 3.59e-01 0.032100 0.661000
Hemostasis 279 3.61e-01 0.032100 0.661000
Epigenetic regulation of gene expression 73 6.38e-01 0.031900 0.853000
Metabolism of lipids 401 2.79e-01 0.031900 0.614000
TCR signaling 77 6.36e-01 -0.031300 0.851000
Constitutive Signaling by EGFRvIII 10 8.65e-01 0.031200 0.948000
Signaling by EGFRvIII in Cancer 10 8.65e-01 0.031200 0.948000
Fc epsilon receptor (FCERI) signaling 100 5.92e-01 -0.031100 0.823000
MAP2K and MAPK activation 22 8.03e-01 0.030700 0.929000
Signaling by high-kinase activity BRAF mutants 22 8.03e-01 0.030700 0.929000
Negative epigenetic regulation of rRNA expression 43 7.29e-01 0.030600 0.897000
EPH-ephrin mediated repulsion of cells 24 7.96e-01 0.030500 0.926000
Semaphorin interactions 34 7.59e-01 0.030500 0.905000
TCF dependent signaling in response to WNT 112 5.79e-01 0.030400 0.816000
Signaling by Interleukins 248 4.16e-01 -0.030200 0.699000
ECM proteoglycans 10 8.70e-01 -0.029900 0.949000
Chromatin modifying enzymes 139 5.46e-01 -0.029800 0.791000
Chromatin organization 139 5.46e-01 -0.029800 0.791000
CD28 co-stimulation 27 7.90e-01 0.029700 0.921000
Interleukin-17 signaling 49 7.22e-01 -0.029500 0.897000
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 15 8.45e-01 0.029200 0.938000
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 15 8.45e-01 0.029200 0.938000
Formation of HIV elongation complex in the absence of HIV Tat 32 7.76e-01 -0.029100 0.913000
RNA Polymerase I Promoter Clearance 43 7.42e-01 0.029100 0.898000
RNA Polymerase I Transcription 43 7.42e-01 0.029100 0.898000
Keratan sulfate/keratin metabolism 18 8.33e-01 0.028800 0.938000
Signaling by the B Cell Receptor (BCR) 84 6.52e-01 -0.028500 0.856000
Sphingolipid de novo biosynthesis 18 8.38e-01 -0.027900 0.938000
Transport of small molecules 320 3.96e-01 0.027800 0.682000
Signaling by FGFR2 in disease 23 8.17e-01 -0.027800 0.934000
Phosphorylation of the APC/C 15 8.53e-01 -0.027600 0.945000
Neutrophil degranulation 275 4.34e-01 -0.027600 0.716000
Metabolism of proteins 1162 1.27e-01 -0.027600 0.452000
Signaling by Nuclear Receptors 145 5.74e-01 0.027200 0.814000
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 8.77e-01 0.026900 0.950000
VEGFR2 mediated cell proliferation 16 8.54e-01 0.026600 0.946000
Signaling by NOTCH3 30 8.02e-01 -0.026400 0.929000
Transcriptional regulation of white adipocyte differentiation 55 7.35e-01 0.026400 0.898000
Selenoamino acid metabolism 76 6.92e-01 -0.026300 0.877000
Neddylation 175 5.56e-01 -0.025900 0.797000
Interleukin-6 family signaling 13 8.72e-01 0.025800 0.950000
The NLRP3 inflammasome 12 8.78e-01 0.025700 0.950000
mRNA Capping 25 8.25e-01 -0.025600 0.935000
Hedgehog ‘on’ state 60 7.32e-01 -0.025600 0.898000
Mitochondrial Fatty Acid Beta-Oxidation 25 8.26e-01 0.025400 0.935000
Generic Transcription Pathway 746 2.48e-01 -0.025400 0.583000
Notch-HLH transcription pathway 21 8.41e-01 0.025300 0.938000
Signaling by VEGF 72 7.15e-01 0.024900 0.895000
Transcriptional Regulation by MECP2 27 8.23e-01 0.024900 0.935000
Initiation of Nuclear Envelope (NE) Reformation 17 8.62e-01 -0.024300 0.948000
Diseases of metabolism 120 6.48e-01 0.024200 0.856000
Signaling by NOTCH 127 6.52e-01 -0.023300 0.856000
RHOB GTPase cycle 40 8.01e-01 -0.023000 0.929000
FCGR3A-mediated IL10 synthesis 19 8.63e-01 -0.022900 0.948000
VEGFA-VEGFR2 Pathway 70 7.42e-01 0.022800 0.898000
MTOR signalling 32 8.23e-01 0.022800 0.935000
Glycogen storage diseases 10 9.01e-01 0.022800 0.969000
Sulfur amino acid metabolism 17 8.73e-01 -0.022400 0.950000
Signaling by Rho GTPases 407 4.46e-01 -0.022300 0.727000
Iron uptake and transport 36 8.22e-01 -0.021700 0.935000
Budding and maturation of HIV virion 22 8.64e-01 0.021100 0.948000
Formation of the Early Elongation Complex 25 8.57e-01 0.020900 0.946000
Formation of the HIV-1 Early Elongation Complex 25 8.57e-01 0.020900 0.946000
TNFR2 non-canonical NF-kB pathway 62 7.78e-01 -0.020800 0.913000
Transferrin endocytosis and recycling 19 8.76e-01 0.020700 0.950000
Signaling by FGFR in disease 38 8.27e-01 0.020500 0.935000
Mitochondrial translation termination 78 7.56e-01 -0.020400 0.904000
Platelet degranulation 45 8.13e-01 0.020400 0.933000
Signaling by Non-Receptor Tyrosine Kinases 33 8.43e-01 -0.019900 0.938000
Signaling by PTK6 33 8.43e-01 -0.019900 0.938000
RNA Polymerase III Transcription Termination 20 8.80e-01 -0.019500 0.951000
EPH-Ephrin signaling 53 8.06e-01 -0.019500 0.931000
Signaling by NTRKs 86 7.58e-01 0.019300 0.905000
Axon guidance 275 6.00e-01 -0.018500 0.827000
NoRC negatively regulates rRNA expression 41 8.39e-01 0.018400 0.938000
Diseases of glycosylation 65 7.99e-01 0.018300 0.928000
Immune System 1056 3.35e-01 0.018100 0.645000
Metabolism of carbohydrates 171 6.92e-01 -0.017600 0.877000
Leishmania infection 103 7.64e-01 0.017200 0.905000
Glycerophospholipid biosynthesis 66 8.11e-01 0.017100 0.933000
Phospholipid metabolism 123 7.45e-01 0.017000 0.898000
Keratan sulfate biosynthesis 14 9.15e-01 0.016400 0.974000
Metabolism of nucleotides 64 8.22e-01 -0.016300 0.935000
Cell death signalling via NRAGE, NRIF and NADE 39 8.61e-01 -0.016200 0.948000
Chaperonin-mediated protein folding 51 8.42e-01 0.016100 0.938000
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 419 5.78e-01 -0.016000 0.816000
Transcriptional Regulation by VENTX 24 8.92e-01 -0.016000 0.961000
Cellular response to chemical stress 137 7.50e-01 0.015800 0.900000
Synthesis of PIPs at the Golgi membrane 12 9.25e-01 -0.015600 0.975000
Gastrin-CREB signalling pathway via PKC and MAPK 11 9.29e-01 -0.015600 0.975000
KEAP1-NFE2L2 pathway 81 8.09e-01 -0.015500 0.932000
Downstream signaling of activated FGFR1 11 9.31e-01 -0.015100 0.975000
Downstream signaling of activated FGFR2 11 9.31e-01 -0.015100 0.975000
Downstream signaling of activated FGFR3 11 9.31e-01 -0.015100 0.975000
Downstream signaling of activated FGFR4 11 9.31e-01 -0.015100 0.975000
Nervous system development 285 6.68e-01 -0.014900 0.863000
Post-chaperonin tubulin folding pathway 12 9.30e-01 0.014700 0.975000
Golgi Associated Vesicle Biogenesis 37 8.78e-01 -0.014600 0.950000
Nuclear events mediated by NFE2L2 63 8.42e-01 -0.014500 0.938000
Glycosphingolipid metabolism 25 9.02e-01 0.014200 0.970000
NCAM signaling for neurite out-growth 21 9.11e-01 0.014000 0.973000
MAPK family signaling cascades 176 7.51e-01 -0.013900 0.900000
Selective autophagy 48 8.68e-01 -0.013900 0.948000
Apoptotic cleavage of cellular proteins 22 9.11e-01 -0.013800 0.973000
Post-translational protein modification 855 5.05e-01 -0.013800 0.758000
Signaling by Insulin receptor 39 8.83e-01 -0.013700 0.953000
Developmental Biology 429 6.32e-01 -0.013600 0.850000
Activation of BAD and translocation to mitochondria 14 9.30e-01 0.013500 0.975000
Negative regulation of MAPK pathway 35 8.91e-01 0.013400 0.961000
Signaling by NTRK1 (TRKA) 79 8.38e-01 0.013400 0.938000
Diseases of mitotic cell cycle 30 8.99e-01 0.013300 0.968000
Mitochondrial biogenesis 52 8.68e-01 -0.013300 0.948000
O-linked glycosylation of mucins 24 9.11e-01 0.013300 0.973000
Glycolysis 54 8.68e-01 -0.013100 0.948000
Protein folding 57 8.65e-01 0.013000 0.948000
PI Metabolism 58 8.65e-01 0.013000 0.948000
Interleukin-4 and Interleukin-13 signaling 48 8.77e-01 -0.012900 0.950000
Mitochondrial translation initiation 79 8.46e-01 -0.012700 0.938000
Inactivation of CSF3 (G-CSF) signaling 18 9.26e-01 -0.012700 0.975000
Activation of the pre-replicative complex 23 9.17e-01 0.012600 0.974000
Class I MHC mediated antigen processing & presentation 265 7.35e-01 0.012200 0.898000
DAP12 signaling 17 9.31e-01 -0.012100 0.975000
Metal ion SLC transporters 15 9.35e-01 -0.012100 0.979000
Negative regulators of DDX58/IFIH1 signaling 32 9.06e-01 0.012100 0.972000
Signaling by TGF-beta Receptor Complex 68 8.65e-01 0.012000 0.948000
Nuclear Envelope (NE) Reassembly 56 8.81e-01 0.011600 0.951000
Regulation of insulin secretion 33 9.09e-01 0.011500 0.973000
RHOU GTPase cycle 28 9.16e-01 -0.011500 0.974000
Regulation of TP53 Activity through Acetylation 26 9.20e-01 -0.011400 0.975000
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 9.41e-01 -0.011000 0.983000
Post-translational modification: synthesis of GPI-anchored proteins 29 9.19e-01 -0.011000 0.974000
MAPK1/MAPK3 signaling 152 8.19e-01 -0.010800 0.935000
Transcriptional activation of mitochondrial biogenesis 39 9.09e-01 -0.010600 0.973000
Signaling by NTRK2 (TRKB) 15 9.47e-01 0.009960 0.987000
Factors involved in megakaryocyte development and platelet production 82 8.77e-01 -0.009940 0.950000
Interleukin-12 family signaling 41 9.14e-01 -0.009750 0.974000
RUNX3 regulates NOTCH signaling 11 9.57e-01 -0.009500 0.988000
Prolonged ERK activation events 13 9.53e-01 -0.009450 0.988000
Synthesis of bile acids and bile salts 12 9.55e-01 0.009320 0.988000
ESR-mediated signaling 110 8.67e-01 -0.009240 0.948000
Signaling by MET 37 9.23e-01 -0.009180 0.975000
Metabolism 1153 6.17e-01 -0.009060 0.835000
Cytosolic sensors of pathogen-associated DNA 52 9.12e-01 -0.008830 0.973000
GAB1 signalosome 10 9.62e-01 0.008720 0.990000
PLC beta mediated events 24 9.42e-01 -0.008600 0.983000
Effects of PIP2 hydrolysis 18 9.51e-01 -0.008410 0.988000
Formation of TC-NER Pre-Incision Complex 45 9.23e-01 -0.008320 0.975000
Formation of the beta-catenin:TCF transactivating complex 22 9.47e-01 0.008180 0.987000
Deadenylation of mRNA 22 9.48e-01 -0.008000 0.987000
Unwinding of DNA 10 9.65e-01 0.007950 0.991000
Innate Immune System 563 7.52e-01 -0.007920 0.901000
Extra-nuclear estrogen signaling 47 9.27e-01 0.007780 0.975000
Interleukin-6 signaling 10 9.66e-01 0.007680 0.991000
Stimuli-sensing channels 35 9.38e-01 0.007550 0.981000
IRS-related events triggered by IGF1R 20 9.54e-01 -0.007380 0.988000
Metabolism of porphyrins 15 9.62e-01 0.007090 0.990000
IRS-mediated signalling 19 9.59e-01 -0.006800 0.989000
E2F mediated regulation of DNA replication 12 9.70e-01 0.006300 0.992000
Transcriptional Regulation by E2F6 26 9.56e-01 -0.006260 0.988000
Ub-specific processing proteases 128 9.06e-01 0.006030 0.972000
Senescence-Associated Secretory Phenotype (SASP) 39 9.49e-01 -0.005970 0.987000
Pyruvate metabolism and Citric Acid (TCA) cycle 38 9.54e-01 -0.005460 0.988000
SHC1 events in ERBB2 signaling 11 9.75e-01 0.005430 0.994000
Assembly Of The HIV Virion 13 9.73e-01 -0.005320 0.994000
Response to elevated platelet cytosolic Ca2+ 49 9.55e-01 0.004710 0.988000
Signal amplification 16 9.75e-01 -0.004540 0.994000
Deubiquitination 189 9.17e-01 -0.004420 0.974000
Glutathione conjugation 18 9.75e-01 -0.004340 0.994000
FLT3 Signaling 27 9.69e-01 -0.004310 0.992000
RHO GTPases Activate NADPH Oxidases 14 9.80e-01 0.003920 0.997000
Potential therapeutics for SARS 63 9.58e-01 -0.003800 0.989000
Signaling by ERBB2 in Cancer 13 9.82e-01 -0.003550 0.998000
Sphingolipid metabolism 43 9.69e-01 -0.003440 0.992000
RHOA GTPase cycle 83 9.65e-01 -0.002780 0.991000
Beta-catenin independent WNT signaling 97 9.64e-01 0.002670 0.991000
Elastic fibre formation 13 9.87e-01 0.002630 0.998000
Inflammasomes 16 9.86e-01 0.002510 0.998000
DDX58/IFIH1-mediated induction of interferon-alpha/beta 55 9.76e-01 -0.002380 0.994000
Inositol phosphate metabolism 29 9.85e-01 -0.002050 0.998000
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 9.90e-01 0.001860 0.998000
Pre-NOTCH Expression and Processing 41 9.86e-01 -0.001610 0.998000
Mitochondrial translation elongation 79 9.83e-01 -0.001400 0.998000
Signalling to RAS 12 9.95e-01 0.001090 0.998000
NRAGE signals death through JNK 24 9.94e-01 -0.000925 0.998000
RAF/MAP kinase cascade 147 9.85e-01 -0.000900 0.998000
Sema4D in semaphorin signaling 13 9.96e-01 0.000838 0.998000
Late endosomal microautophagy 21 9.95e-01 -0.000834 0.998000
Interferon gamma signaling 50 9.93e-01 0.000764 0.998000
Synthesis of PC 21 9.95e-01 0.000723 0.998000
Interleukin-37 signaling 15 9.97e-01 0.000604 0.998000
Postmitotic nuclear pore complex (NPC) reformation 25 9.97e-01 -0.000477 0.998000
SUMOylation of chromatin organization proteins 45 9.96e-01 -0.000427 0.998000
Activated NOTCH1 Transmits Signal to the Nucleus 19 9.98e-01 -0.000407 0.998000
BMAL1:CLOCK,NPAS2 activates circadian gene expression 15 9.98e-01 -0.000373 0.998000
MHC class II antigen presentation 66 9.98e-01 -0.000212 0.998000


Detailed Gene set reports



Purine catabolism

Purine catabolism
723
set Purine catabolism
setSize 10
pANOVA 0.00917
s.dist -0.476
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
NT5C -8902.0
PNP -8273.0
NUDT15 -8164.0
NUDT16 -7893.0
ITPA -7113.0
NT5C2 -6272.0
NUDT9 -5480.0
NUDT5 -4949.0
NUDT1 -3852.5
NUDT18 -2807.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NT5C -8902.0
PNP -8273.0
NUDT15 -8164.0
NUDT16 -7893.0
ITPA -7113.0
NT5C2 -6272.0
NUDT9 -5480.0
NUDT5 -4949.0
NUDT1 -3852.5
NUDT18 -2807.0


Meiotic recombination

Meiotic recombination
519
set Meiotic recombination
setSize 19
pANOVA 0.000838
s.dist -0.443
p.adjustANOVA 0.0515



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
MSH5 -8789.0
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
PSMC3IP -8067.0
MND1 -7741.0
BLM -7501.0
TOP3A -7020.5
RPA3 -6328.0
CDK4 -6073.0
MLH3 -5573.0
DMC1 -4318.0
H2AFX -3494.0
RPA1 -3377.5
CDK2 -3323.5
RAD50 -1967.0
NBN -1658.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
MSH5 -8789.0
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
PSMC3IP -8067.0
MND1 -7741.0
BLM -7501.0
TOP3A -7020.5
RPA3 -6328.0
CDK4 -6073.0
MLH3 -5573.0
DMC1 -4318.0
H2AFX -3494.0
RPA1 -3377.5
CDK2 -3323.5
RAD50 -1967.0
NBN -1658.0


p75NTR signals via NF-kB

p75NTR signals via NF-kB
1160
set p75NTR signals via NF-kB
setSize 11
pANOVA 0.0118
s.dist -0.439
p.adjustANOVA 0.164



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
NFKBIA -8516.0
MYD88 -8048.0
IKBKB -7351.0
TRAF6 -7283.0
UBB -7240.0
SQSTM1 -6839.0
PRKCI -5240.0
UBA52 -634.0
RELA 353.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
NFKBIA -8516.0
MYD88 -8048.0
IKBKB -7351.0
TRAF6 -7283.0
UBB -7240.0
SQSTM1 -6839.0
PRKCI -5240.0
UBA52 -634.0
RELA 353.0


Negative regulation of NMDA receptor-mediated neuronal transmission

Negative regulation of NMDA receptor-mediated neuronal transmission
605
set Negative regulation of NMDA receptor-mediated neuronal transmission
setSize 11
pANOVA 0.0126
s.dist 0.435
p.adjustANOVA 0.173



Top enriched genes

Top 20 genes
GeneID Gene Rank
CAMK1 855.0
DLG1 633.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
CAMK4 -481.0
CALM1 -817.0
PPM1F -2994.0
DLG4 -3314.0
CAMK2D -6176.0
DLG2 -8562.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAMK1 855.0
DLG1 633.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
CAMK4 -481.0
CALM1 -817.0
PPM1F -2994.0
DLG4 -3314.0
CAMK2D -6176.0
DLG2 -8562.0


Signaling by Leptin

Signaling by Leptin
961
set Signaling by Leptin
setSize 10
pANOVA 0.0182
s.dist 0.431
p.adjustANOVA 0.209



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRS2 875.0
SOCS3 652.0
JAK2 0.5
LEPR -443.5
STAT5A -929.0
STAT5B -1073.0
SH2B1 -1515.0
STAT3 -2825.0
PTPN11 -6287.0
IRS1 -7564.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 875.0
SOCS3 652.0
JAK2 0.5
LEPR -443.5
STAT5A -929.0
STAT5B -1073.0
SH2B1 -1515.0
STAT3 -2825.0
PTPN11 -6287.0
IRS1 -7564.0


Signaling by BMP

Signaling by BMP
929
set Signaling by BMP
setSize 14
pANOVA 0.00553
s.dist 0.428
p.adjustANOVA 0.13



Top enriched genes

Top 20 genes
GeneID Gene Rank
SMURF2 883.0
ACVR2A 0.5
BMPR2 0.5
BMPR1A 0.5
SMAD7 0.5
ACVR2B -908.5
SKI -1033.0
SMAD1 -1553.0
UBE2D3 -1554.5
SMURF1 -2491.0
UBE2D1 -4090.0
SMAD6 -4422.0
SMAD5 -5681.5
ZFYVE16 -6129.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMURF2 883.0
ACVR2A 0.5
BMPR2 0.5
BMPR1A 0.5
SMAD7 0.5
ACVR2B -908.5
SKI -1033.0
SMAD1 -1553.0
UBE2D3 -1554.5
SMURF1 -2491.0
UBE2D1 -4090.0
SMAD6 -4422.0
SMAD5 -5681.5
ZFYVE16 -6129.0


IKK complex recruitment mediated by RIP1

IKK complex recruitment mediated by RIP1
417
set IKK complex recruitment mediated by RIP1
setSize 17
pANOVA 0.00663
s.dist -0.38
p.adjustANOVA 0.138



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
CHUK -8055.0
RIPK3 -7627.0
IKBKB -7351.0
TRAF6 -7283.0
UBB -7240.0
UBE2D2 -6859.0
TICAM1 -6700.0
SARM1 -6652.0
BIRC2 -5780.0
UBE2V1 -5429.0
UBE2D1 -4090.0
UBE2N -4053.0
BIRC3 -3734.0
UBE2D3 -1554.5
UBA52 -634.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
CHUK -8055.0
RIPK3 -7627.0
IKBKB -7351.0
TRAF6 -7283.0
UBB -7240.0
UBE2D2 -6859.0
TICAM1 -6700.0
SARM1 -6652.0
BIRC2 -5780.0
UBE2V1 -5429.0
UBE2D1 -4090.0
UBE2N -4053.0
BIRC3 -3734.0
UBE2D3 -1554.5
UBA52 -634.0


Ras activation upon Ca2+ influx through NMDA receptor

Ras activation upon Ca2+ influx through NMDA receptor
805
set Ras activation upon Ca2+ influx through NMDA receptor
setSize 10
pANOVA 0.0396
s.dist 0.376
p.adjustANOVA 0.279



Top enriched genes

Top 20 genes
GeneID Gene Rank
DLG1 633.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
HRAS -508.0
CALM1 -817.0
KRAS -3095.0
DLG4 -3314.0
CAMK2D -6176.0
DLG2 -8562.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLG1 633.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
HRAS -508.0
CALM1 -817.0
KRAS -3095.0
DLG4 -3314.0
CAMK2D -6176.0
DLG2 -8562.0


Potassium Channels

Potassium Channels
701
set Potassium Channels
setSize 23
pANOVA 0.00189
s.dist 0.374
p.adjustANOVA 0.0919



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNG4 869.0
KCNQ1 848.5
GNG2 620.0
KCNA3 592.0
GNG12 0.5
GABBR1 0.5
KCNC4 0.5
KCNG3 0.5
GNGT2 0.5
KCNQ5 -497.0
KCNK6 -664.0
KCNH4 -876.0
KCNMB4 -1430.0
GNG5 -3127.5
GNB1 -4107.0
KCNQ4 -4242.0
KCNAB2 -4418.0
GNB5 -4674.0
KCNJ11 -4765.0
GNG3 -5234.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNG4 869.0
KCNQ1 848.5
GNG2 620.0
KCNA3 592.0
GNG12 0.5
GABBR1 0.5
KCNC4 0.5
KCNG3 0.5
GNGT2 0.5
KCNQ5 -497.0
KCNK6 -664.0
KCNH4 -876.0
KCNMB4 -1430.0
GNG5 -3127.5
GNB1 -4107.0
KCNQ4 -4242.0
KCNAB2 -4418.0
GNB5 -4674.0
KCNJ11 -4765.0
GNG3 -5234.0
KCNN4 -5352.0
HCN3 -5548.0
GNB2 -8449.0


SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy
879
set SARS-CoV-2 modulates autophagy
setSize 10
pANOVA 0.0467
s.dist -0.363
p.adjustANOVA 0.313



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS39 -8119.0
UVRAG -7478.0
VPS18 -7033.0
VPS16 -6035.5
VPS41 -5652.0
VPS45 -5497.0
VPS33A -5185.0
VPS11 -5056.0
MAP1LC3B -4785.0
TUFM -3334.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS39 -8119.0
UVRAG -7478.0
VPS18 -7033.0
VPS16 -6035.5
VPS41 -5652.0
VPS45 -5497.0
VPS33A -5185.0
VPS11 -5056.0
MAP1LC3B -4785.0
TUFM -3334.0


tRNA Aminoacylation

tRNA Aminoacylation
1165
set tRNA Aminoacylation
setSize 22
pANOVA 0.00321
s.dist -0.363
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
NARS2 -8388.0
DARS2 -8101.5
HARS2 -7957.5
MARS2 -7890.0
FARSB -7844.0
AIMP2 -7587.5
EARS2 -7568.5
CARS2 -7259.0
RARS2 -7219.5
IARS2 -7183.0
AARS2 -6759.0
FARS2 -6024.5
PARS2 -5702.0
SARS2 -5543.5
EEF1E1 -5514.0
YARS2 -4648.0
FARSA -4442.0
PPA1 -3935.0
PPA2 -3617.0
WARS2 -1872.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NARS2 -8388.0
DARS2 -8101.5
HARS2 -7957.5
MARS2 -7890.0
FARSB -7844.0
AIMP2 -7587.5
EARS2 -7568.5
CARS2 -7259.0
RARS2 -7219.5
IARS2 -7183.0
AARS2 -6759.0
FARS2 -6024.5
PARS2 -5702.0
SARS2 -5543.5
EEF1E1 -5514.0
YARS2 -4648.0
FARSA -4442.0
PPA1 -3935.0
PPA2 -3617.0
WARS2 -1872.0
VARS2 -1656.0
TARS2 -1190.0


Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs
712
set Processing of Intronless Pre-mRNAs
setSize 15
pANOVA 0.0153
s.dist -0.362
p.adjustANOVA 0.197



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLP1 -8773.0
NUDT21 -8451.5
CSTF1 -8202.5
CPSF2 -7963.5
PAPOLA -7720.0
CPSF1 -7599.0
SYMPK -7355.0
NCBP1 -6163.5
CPSF3 -5893.5
FIP1L1 -5106.0
PABPN1 -4971.0
CPSF4 -4246.5
WDR33 -3644.0
NCBP2 -1030.5
CPSF6 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLP1 -8773.0
NUDT21 -8451.5
CSTF1 -8202.5
CPSF2 -7963.5
PAPOLA -7720.0
CPSF1 -7599.0
SYMPK -7355.0
NCBP1 -6163.5
CPSF3 -5893.5
FIP1L1 -5106.0
PABPN1 -4971.0
CPSF4 -4246.5
WDR33 -3644.0
NCBP2 -1030.5
CPSF6 0.5


Mitochondrial tRNA aminoacylation

Mitochondrial tRNA aminoacylation
555
set Mitochondrial tRNA aminoacylation
setSize 17
pANOVA 0.0102
s.dist -0.36
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
NARS2 -8388.0
DARS2 -8101.5
HARS2 -7957.5
MARS2 -7890.0
EARS2 -7568.5
CARS2 -7259.0
RARS2 -7219.5
IARS2 -7183.0
AARS2 -6759.0
FARS2 -6024.5
PARS2 -5702.0
SARS2 -5543.5
YARS2 -4648.0
PPA2 -3617.0
WARS2 -1872.0
VARS2 -1656.0
TARS2 -1190.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NARS2 -8388.0
DARS2 -8101.5
HARS2 -7957.5
MARS2 -7890.0
EARS2 -7568.5
CARS2 -7259.0
RARS2 -7219.5
IARS2 -7183.0
AARS2 -6759.0
FARS2 -6024.5
PARS2 -5702.0
SARS2 -5543.5
YARS2 -4648.0
PPA2 -3617.0
WARS2 -1872.0
VARS2 -1656.0
TARS2 -1190.0


Mucopolysaccharidoses

Mucopolysaccharidoses
569
set Mucopolysaccharidoses
setSize 10
pANOVA 0.0532
s.dist 0.353
p.adjustANOVA 0.331



Top enriched genes

Top 20 genes
GeneID Gene Rank
HYAL1 0.5
GALNS -739.5
SGSH -971.5
IDUA -1665.5
HGSNAT -1808.0
GLB1 -2090.5
ARSB -2116.0
GUSB -3581.0
GNS -4037.0
NAGLU -5949.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HYAL1 0.5
GALNS -739.5
SGSH -971.5
IDUA -1665.5
HGSNAT -1808.0
GLB1 -2090.5
ARSB -2116.0
GUSB -3581.0
GNS -4037.0
NAGLU -5949.0


HDMs demethylate histones

HDMs demethylate histones
390
set HDMs demethylate histones
setSize 15
pANOVA 0.0199
s.dist -0.347
p.adjustANOVA 0.219



Top enriched genes

Top 20 genes
GeneID Gene Rank
KDM4A -8848.0
KDM6B -8725.0
KDM2A -8711.0
KDM1A -7955.0
KDM3A -7939.0
KDM5A -7913.0
KDM2B -7640.0
KDM4C -7422.0
KDM1B -7228.5
JMJD6 -4024.5
ARID5B -3611.0
MINA -2120.0
KDM4D -2052.5
KDM4B -1273.0
KDM3B -602.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KDM4A -8848.0
KDM6B -8725.0
KDM2A -8711.0
KDM1A -7955.0
KDM3A -7939.0
KDM5A -7913.0
KDM2B -7640.0
KDM4C -7422.0
KDM1B -7228.5
JMJD6 -4024.5
ARID5B -3611.0
MINA -2120.0
KDM4D -2052.5
KDM4B -1273.0
KDM3B -602.0


Collagen degradation

Collagen degradation
156
set Collagen degradation
setSize 10
pANOVA 0.0594
s.dist 0.344
p.adjustANOVA 0.342



Top enriched genes

Top 20 genes
GeneID Gene Rank
FURIN 0.5
COL9A2 -603.0
ADAM9 -822.5
CTSD -860.5
ADAM10 -1021.0
CTSB -2370.0
COL23A1 -2745.0
COL19A1 -3064.0
MMP15 -4235.0
ADAM17 -7668.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FURIN 0.5
COL9A2 -603.0
ADAM9 -822.5
CTSD -860.5
ADAM10 -1021.0
CTSB -2370.0
COL23A1 -2745.0
COL19A1 -3064.0
MMP15 -4235.0
ADAM17 -7668.0


Erythropoietin activates RAS

Erythropoietin activates RAS
282
set Erythropoietin activates RAS
setSize 10
pANOVA 0.0594
s.dist 0.344
p.adjustANOVA 0.342



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRS2 875.0
EPOR 757.0
JAK2 0.5
HRAS -508.0
RAPGEF1 -665.0
GRB2 -2995.0
KRAS -3095.0
CRKL -4536.0
VAV1 -5496.0
SHC1 -7728.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 875.0
EPOR 757.0
JAK2 0.5
HRAS -508.0
RAPGEF1 -665.0
GRB2 -2995.0
KRAS -3095.0
CRKL -4536.0
VAV1 -5496.0
SHC1 -7728.5


Interleukin-20 family signaling

Interleukin-20 family signaling
463
set Interleukin-20 family signaling
setSize 13
pANOVA 0.0362
s.dist 0.336
p.adjustANOVA 0.272



Top enriched genes

Top 20 genes
GeneID Gene Rank
SOCS3 652.0
IL19 0.5
JAK2 0.5
JAK1 -838.0
STAT2 -877.0
STAT5A -929.0
STAT5B -1073.0
STAT3 -2825.0
IL10RB -3086.0
STAT4 -3326.0
TYK2 -3971.0
PTPN11 -6287.0
STAT1 -8416.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SOCS3 652.0
IL19 0.5
JAK2 0.5
JAK1 -838.0
STAT2 -877.0
STAT5A -929.0
STAT5B -1073.0
STAT3 -2825.0
IL10RB -3086.0
STAT4 -3326.0
TYK2 -3971.0
PTPN11 -6287.0
STAT1 -8416.0


RIPK1-mediated regulated necrosis

RIPK1-mediated regulated necrosis
764
set RIPK1-mediated regulated necrosis
setSize 24
pANOVA 0.00458
s.dist -0.334
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
FAS -8683.5
UBC -8547.0
FLOT1 -7796.0
CFLAR -7775.0
RIPK3 -7627.0
UBB -7240.0
FLOT2 -7092.0
HSP90AA1 -6691.0
TRADD -6427.5
PELI1 -6415.0
CASP8 -6169.0
TNFRSF10A -6070.0
BIRC2 -5780.0
CDC37 -5647.5
TNFRSF10B -5205.0
TRAF2 -4778.0
PDCD6IP -4136.0
STUB1 -3895.0
BIRC3 -3734.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
FAS -8683.5
UBC -8547.0
FLOT1 -7796.0
CFLAR -7775.0
RIPK3 -7627.0
UBB -7240.0
FLOT2 -7092.0
HSP90AA1 -6691.0
TRADD -6427.5
PELI1 -6415.0
CASP8 -6169.0
TNFRSF10A -6070.0
BIRC2 -5780.0
CDC37 -5647.5
TNFRSF10B -5205.0
TRAF2 -4778.0
PDCD6IP -4136.0
STUB1 -3895.0
BIRC3 -3734.0
TNFSF10 -2568.0
MLKL -2389.0
FADD -2144.0
UBA52 -634.0


Regulation of necroptotic cell death

Regulation of necroptotic cell death
850
set Regulation of necroptotic cell death
setSize 24
pANOVA 0.00458
s.dist -0.334
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
FAS -8683.5
UBC -8547.0
FLOT1 -7796.0
CFLAR -7775.0
RIPK3 -7627.0
UBB -7240.0
FLOT2 -7092.0
HSP90AA1 -6691.0
TRADD -6427.5
PELI1 -6415.0
CASP8 -6169.0
TNFRSF10A -6070.0
BIRC2 -5780.0
CDC37 -5647.5
TNFRSF10B -5205.0
TRAF2 -4778.0
PDCD6IP -4136.0
STUB1 -3895.0
BIRC3 -3734.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
FAS -8683.5
UBC -8547.0
FLOT1 -7796.0
CFLAR -7775.0
RIPK3 -7627.0
UBB -7240.0
FLOT2 -7092.0
HSP90AA1 -6691.0
TRADD -6427.5
PELI1 -6415.0
CASP8 -6169.0
TNFRSF10A -6070.0
BIRC2 -5780.0
CDC37 -5647.5
TNFRSF10B -5205.0
TRAF2 -4778.0
PDCD6IP -4136.0
STUB1 -3895.0
BIRC3 -3734.0
TNFSF10 -2568.0
MLKL -2389.0
FADD -2144.0
UBA52 -634.0


Activation of G protein gated Potassium channels

Activation of G protein gated Potassium channels
29
set Activation of G protein gated Potassium channels
setSize 10
pANOVA 0.0709
s.dist 0.33
p.adjustANOVA 0.361



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GABBR1 0.5
GNGT2 0.5
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GABBR1 0.5
GNGT2 0.5
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0


G protein gated Potassium channels

G protein gated Potassium channels
333
set G protein gated Potassium channels
setSize 10
pANOVA 0.0709
s.dist 0.33
p.adjustANOVA 0.361



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GABBR1 0.5
GNGT2 0.5
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GABBR1 0.5
GNGT2 0.5
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0


Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
434
set Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
setSize 10
pANOVA 0.0709
s.dist 0.33
p.adjustANOVA 0.361



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GABBR1 0.5
GNGT2 0.5
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GABBR1 0.5
GNGT2 0.5
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0


Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand
116
set Caspase activation via Death Receptors in the presence of ligand
setSize 10
pANOVA 0.0711
s.dist -0.33
p.adjustANOVA 0.361



Top enriched genes

Top 20 genes
GeneID Gene Rank
FAS -8683.5
CFLAR -7775.0
TICAM1 -6700.0
TRADD -6427.5
CASP8 -6169.0
TNFRSF10A -6070.0
TNFRSF10B -5205.0
TRAF2 -4778.0
TNFSF10 -2568.0
FADD -2144.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FAS -8683.5
CFLAR -7775.0
TICAM1 -6700.0
TRADD -6427.5
CASP8 -6169.0
TNFRSF10A -6070.0
TNFRSF10B -5205.0
TRAF2 -4778.0
TNFSF10 -2568.0
FADD -2144.0


Activation of kainate receptors upon glutamate binding

Activation of kainate receptors upon glutamate binding
37
set Activation of kainate receptors upon glutamate binding
setSize 15
pANOVA 0.0272
s.dist 0.329
p.adjustANOVA 0.248



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNG4 869.0
DLG1 633.0
GNG2 620.0
GNG12 0.5
NCALD 0.5
GNGT2 0.5
CALM1 -817.0
PLCB3 -933.0
GNG5 -3127.5
DLG4 -3314.0
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
PLCB2 -7661.0
GNB2 -8449.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNG4 869.0
DLG1 633.0
GNG2 620.0
GNG12 0.5
NCALD 0.5
GNGT2 0.5
CALM1 -817.0
PLCB3 -933.0
GNG5 -3127.5
DLG4 -3314.0
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
PLCB2 -7661.0
GNB2 -8449.0


Signaling by Erythropoietin

Signaling by Erythropoietin
942
set Signaling by Erythropoietin
setSize 18
pANOVA 0.0158
s.dist 0.329
p.adjustANOVA 0.197



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRS2 875.0
EPOR 757.0
JAK2 0.5
HRAS -508.0
RAPGEF1 -665.0
STAT5A -929.0
STAT5B -1073.0
PLCG1 -1151.0
PIK3CA -1214.0
PIK3CD -2551.0
PIK3R5 -2838.0
GRB2 -2995.0
KRAS -3095.0
CRKL -4536.0
PIK3R1 -4577.0
VAV1 -5496.0
PLCG2 -5781.0
SHC1 -7728.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 875.0
EPOR 757.0
JAK2 0.5
HRAS -508.0
RAPGEF1 -665.0
STAT5A -929.0
STAT5B -1073.0
PLCG1 -1151.0
PIK3CA -1214.0
PIK3CD -2551.0
PIK3R5 -2838.0
GRB2 -2995.0
KRAS -3095.0
CRKL -4536.0
PIK3R1 -4577.0
VAV1 -5496.0
PLCG2 -5781.0
SHC1 -7728.5


Translesion Synthesis by POLH

Translesion Synthesis by POLH
1097
set Translesion Synthesis by POLH
setSize 16
pANOVA 0.0235
s.dist -0.327
p.adjustANOVA 0.229



Top enriched genes

Top 20 genes
GeneID Gene Rank
UFD1L -8911.5
RPS27A -8712.5
RFC5 -8619.0
UBC -8547.0
RFC3 -8030.0
UBB -7240.0
RPA3 -6328.0
RFC2 -5672.0
NPLOC4 -5447.0
PCNA -5027.0
VCP -4870.0
RCHY1 -4515.5
POLH -3833.5
RPA1 -3377.5
UBA52 -634.0
RFC4 -456.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UFD1L -8911.5
RPS27A -8712.5
RFC5 -8619.0
UBC -8547.0
RFC3 -8030.0
UBB -7240.0
RPA3 -6328.0
RFC2 -5672.0
NPLOC4 -5447.0
PCNA -5027.0
VCP -4870.0
RCHY1 -4515.5
POLH -3833.5
RPA1 -3377.5
UBA52 -634.0
RFC4 -456.0


Impaired BRCA2 binding to RAD51

Impaired BRCA2 binding to RAD51
425
set Impaired BRCA2 binding to RAD51
setSize 30
pANOVA 0.00196
s.dist -0.327
p.adjustANOVA 0.0919



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
ATR -8697.0
RFC5 -8619.0
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
KAT5 -8198.0
RFC3 -8030.0
RAD9B -7770.5
BLM -7501.0
RMI1 -7389.5
DNA2 -7266.0
TOP3A -7020.5
RAD1 -6683.5
RPA3 -6328.0
EXO1 -6078.0
RFC2 -5672.0
HUS1 -5490.0
RAD17 -5393.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
ATR -8697.0
RFC5 -8619.0
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
KAT5 -8198.0
RFC3 -8030.0
RAD9B -7770.5
BLM -7501.0
RMI1 -7389.5
DNA2 -7266.0
TOP3A -7020.5
RAD1 -6683.5
RPA3 -6328.0
EXO1 -6078.0
RFC2 -5672.0
HUS1 -5490.0
RAD17 -5393.5
WRN -4029.5
RPA1 -3377.5
RAD9A -3132.0
TOPBP1 -3108.0
ATRIP -2471.0
RAD50 -1967.0
NBN -1658.0
RFC4 -456.0
BARD1 -363.0
BRIP1 349.0


Mitochondrial calcium ion transport

Mitochondrial calcium ion transport
552
set Mitochondrial calcium ion transport
setSize 14
pANOVA 0.0347
s.dist 0.326
p.adjustANOVA 0.268



Top enriched genes

Top 20 genes
GeneID Gene Rank
VDAC1 369.0
PHB 0.5
SLC8A3 -327.0
PMPCB -418.0
PARL -539.0
LETM1 -558.0
AFG3L2 -965.0
STOML2 -1249.0
AKAP1 -2965.0
C2orf47 -3718.5
YME1L1 -3986.5
SPG7 -5019.0
VDAC3 -6667.0
PHB2 -7976.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VDAC1 369.0
PHB 0.5
SLC8A3 -327.0
PMPCB -418.0
PARL -539.0
LETM1 -558.0
AFG3L2 -965.0
STOML2 -1249.0
AKAP1 -2965.0
C2orf47 -3718.5
YME1L1 -3986.5
SPG7 -5019.0
VDAC3 -6667.0
PHB2 -7976.5


Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization
382
set Golgi Cisternae Pericentriolar Stack Reorganization
setSize 14
pANOVA 0.0358
s.dist -0.324
p.adjustANOVA 0.272



Top enriched genes

Top 20 genes
GeneID Gene Rank
BLZF1 -8775.5
RAB1B -8437.0
USO1 -8317.0
CCNB1 -7466.0
RAB2A -7141.0
RAB1A -5713.0
MAPK3 -5593.0
CCNB2 -5187.0
GOLGA2 -4449.5
PLK1 -4291.0
CDK1 -4141.5
GORASP1 -3687.5
MAPK1 -3485.0
GORASP2 -2051.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BLZF1 -8775.5
RAB1B -8437.0
USO1 -8317.0
CCNB1 -7466.0
RAB2A -7141.0
RAB1A -5713.0
MAPK3 -5593.0
CCNB2 -5187.0
GOLGA2 -4449.5
PLK1 -4291.0
CDK1 -4141.5
GORASP1 -3687.5
MAPK1 -3485.0
GORASP2 -2051.0


Interleukin-10 signaling

Interleukin-10 signaling
457
set Interleukin-10 signaling
setSize 12
pANOVA 0.0521
s.dist 0.324
p.adjustANOVA 0.327



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCR1 768.0
TNFRSF1A 0.5
IL10RA -775.0
JAK1 -838.0
TNF -1324.0
STAT3 -2825.0
IL10RB -3086.0
CSF1 -3126.0
IL12A -3564.0
TNFRSF1B -3794.0
TYK2 -3971.0
ICAM1 -6745.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCR1 768.0
TNFRSF1A 0.5
IL10RA -775.0
JAK1 -838.0
TNF -1324.0
STAT3 -2825.0
IL10RB -3086.0
CSF1 -3126.0
IL12A -3564.0
TNFRSF1B -3794.0
TYK2 -3971.0
ICAM1 -6745.0


Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
1118
set Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
setSize 15
pANOVA 0.0308
s.dist -0.322
p.adjustANOVA 0.261



Top enriched genes

Top 20 genes
GeneID Gene Rank
YWHAB -8384.0
EXOSC8 -7726.0
DCP2 -7526.0
EXOSC7 -7156.5
DIS3 -7121.5
EXOSC2 -7070.0
ZFP36 -7042.0
DCP1A -6234.0
EXOSC4 -5984.0
EXOSC5 -5558.5
EXOSC1 -5102.5
MAPKAPK2 -4780.0
TNPO1 -2833.0
EXOSC6 -1100.0
EXOSC3 -598.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YWHAB -8384.0
EXOSC8 -7726.0
DCP2 -7526.0
EXOSC7 -7156.5
DIS3 -7121.5
EXOSC2 -7070.0
ZFP36 -7042.0
DCP1A -6234.0
EXOSC4 -5984.0
EXOSC5 -5558.5
EXOSC1 -5102.5
MAPKAPK2 -4780.0
TNPO1 -2833.0
EXOSC6 -1100.0
EXOSC3 -598.0


Chaperone Mediated Autophagy

Chaperone Mediated Autophagy
136
set Chaperone Mediated Autophagy
setSize 12
pANOVA 0.0544
s.dist -0.321
p.adjustANOVA 0.336



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
ARL13B -7442.0
PARK7 -7246.0
UBB -7240.0
HSP90AA1 -6691.0
EEF1A1 -6367.0
HSP90AB1 -6165.0
PLIN3 -4399.0
PCNT -2266.0
PLIN2 -1586.0
UBA52 -634.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
ARL13B -7442.0
PARK7 -7246.0
UBB -7240.0
HSP90AA1 -6691.0
EEF1A1 -6367.0
HSP90AB1 -6165.0
PLIN3 -4399.0
PCNT -2266.0
PLIN2 -1586.0
UBA52 -634.0


Downregulation of ERBB2 signaling

Downregulation of ERBB2 signaling
245
set Downregulation of ERBB2 signaling
setSize 17
pANOVA 0.0222
s.dist -0.32
p.adjustANOVA 0.223



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
RNF41 -8704.0
PTPN12 -8616.0
UBC -8547.0
PTPN18 -7656.0
UBB -7240.0
CUL5 -6794.0
HSP90AA1 -6691.0
USP8 -6334.0
HBEGF -5667.0
CDC37 -5647.5
ERBB2 -4746.5
STUB1 -3895.0
AKT2 -3115.0
AKT1 -2293.0
UBA52 -634.0
ERBB3 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
RNF41 -8704.0
PTPN12 -8616.0
UBC -8547.0
PTPN18 -7656.0
UBB -7240.0
CUL5 -6794.0
HSP90AA1 -6691.0
USP8 -6334.0
HBEGF -5667.0
CDC37 -5647.5
ERBB2 -4746.5
STUB1 -3895.0
AKT2 -3115.0
AKT1 -2293.0
UBA52 -634.0
ERBB3 0.5


TICAM1, RIP1-mediated IKK complex recruitment

TICAM1, RIP1-mediated IKK complex recruitment
1032
set TICAM1, RIP1-mediated IKK complex recruitment
setSize 17
pANOVA 0.0225
s.dist -0.32
p.adjustANOVA 0.223



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
CHUK -8055.0
RIPK3 -7627.0
IKBKB -7351.0
TRAF6 -7283.0
UBB -7240.0
UBE2D2 -6859.0
TICAM1 -6700.0
BIRC2 -5780.0
UBE2V1 -5429.0
UBE2D1 -4090.0
UBE2N -4053.0
BIRC3 -3734.0
TLR3 -1577.0
UBE2D3 -1554.5
UBA52 -634.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
CHUK -8055.0
RIPK3 -7627.0
IKBKB -7351.0
TRAF6 -7283.0
UBB -7240.0
UBE2D2 -6859.0
TICAM1 -6700.0
BIRC2 -5780.0
UBE2V1 -5429.0
UBE2D1 -4090.0
UBE2N -4053.0
BIRC3 -3734.0
TLR3 -1577.0
UBE2D3 -1554.5
UBA52 -634.0


RHO GTPases activate CIT

RHO GTPases activate CIT
746
set RHO GTPases activate CIT
setSize 14
pANOVA 0.0387
s.dist -0.319
p.adjustANOVA 0.276



Top enriched genes

Top 20 genes
GeneID Gene Rank
RHOA -8845.5
PPP1R12A -8747.0
KIF14 -8455.0
PPP1R12B -8133.0
CIT -7187.0
MYL6 -7079.0
CDKN1B -6833.0
MYH10 -5399.0
RHOB -4872.0
MYH9 -3866.0
DLG4 -3314.0
RAC1 -2453.0
PPP1CB -1680.0
PRC1 -1532.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RHOA -8845.5
PPP1R12A -8747.0
KIF14 -8455.0
PPP1R12B -8133.0
CIT -7187.0
MYL6 -7079.0
CDKN1B -6833.0
MYH10 -5399.0
RHOB -4872.0
MYH9 -3866.0
DLG4 -3314.0
RAC1 -2453.0
PPP1CB -1680.0
PRC1 -1532.0


Glycogen synthesis

Glycogen synthesis
376
set Glycogen synthesis
setSize 11
pANOVA 0.0669
s.dist -0.319
p.adjustANOVA 0.36



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
UGP2 -8608.0
UBC -8547.0
PGM2 -8095.0
PGM1 -7755.0
UBB -7240.0
GYS1 -5628.5
PGM2L1 -4508.0
GYG1 -2723.0
UBA52 -634.0
NHLRC1 856.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
UGP2 -8608.0
UBC -8547.0
PGM2 -8095.0
PGM1 -7755.0
UBB -7240.0
GYS1 -5628.5
PGM2L1 -4508.0
GYG1 -2723.0
UBA52 -634.0
NHLRC1 856.0


Signaling by WNT in cancer

Signaling by WNT in cancer
995
set Signaling by WNT in cancer
setSize 22
pANOVA 0.0104
s.dist 0.316
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
WNT3A 823.0
FZD8 717.0
CTBP1 0.5
LRP5 0.5
FZD5 -735.0
LRP6 -954.0
PPP2R5E -1172.0
PPP2R1B -1211.0
GSK3B -1568.0
PPP2CB -1685.0
AXIN1 -2143.0
CSNK1A1 -2210.0
TNKS2 -2298.0
TNKS -2848.0
PPP2R5D -3194.0
FZD6 -3925.0
PPP2R5C -3931.0
APC -4548.0
PPP2R5A -5091.0
PPP2R5B -6090.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT3A 823.0
FZD8 717.0
CTBP1 0.5
LRP5 0.5
FZD5 -735.0
LRP6 -954.0
PPP2R5E -1172.0
PPP2R1B -1211.0
GSK3B -1568.0
PPP2CB -1685.0
AXIN1 -2143.0
CSNK1A1 -2210.0
TNKS2 -2298.0
TNKS -2848.0
PPP2R5D -3194.0
FZD6 -3925.0
PPP2R5C -3931.0
APC -4548.0
PPP2R5A -5091.0
PPP2R5B -6090.0
CTNNB1 -6204.0
PPP2CA -6314.0


Cytosolic sulfonation of small molecules

Cytosolic sulfonation of small molecules
179
set Cytosolic sulfonation of small molecules
setSize 10
pANOVA 0.0847
s.dist 0.315
p.adjustANOVA 0.39



Top enriched genes

Top 20 genes
GeneID Gene Rank
TPST1 405.0
PODXL2 0.5
SLC35B2 -1288.0
TPST2 -1422.0
SLC26A1 -1665.5
BPNT1 -3219.0
SLC35B3 -3318.0
ABHD14B -4039.5
PAPSS1 -4204.0
SLC26A2 -6087.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPST1 405.0
PODXL2 0.5
SLC35B2 -1288.0
TPST2 -1422.0
SLC26A1 -1665.5
BPNT1 -3219.0
SLC35B3 -3318.0
ABHD14B -4039.5
PAPSS1 -4204.0
SLC26A2 -6087.0


Negative regulation of FLT3

Negative regulation of FLT3
602
set Negative regulation of FLT3
setSize 10
pANOVA 0.0848
s.dist -0.315
p.adjustANOVA 0.39



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
FLT3LG -8264.0
UBB -7240.0
CSK -6881.0
CBL -5176.0
SOCS2 -4505.0
ABL2 -3394.0
SH2B3 -2434.0
UBA52 -634.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -8712.5
UBC -8547.0
FLT3LG -8264.0
UBB -7240.0
CSK -6881.0
CBL -5176.0
SOCS2 -4505.0
ABL2 -3394.0
SH2B3 -2434.0
UBA52 -634.0


Cell-cell junction organization

Cell-cell junction organization
127
set Cell-cell junction organization
setSize 12
pANOVA 0.0593
s.dist 0.315
p.adjustANOVA 0.342



Top enriched genes

Top 20 genes
GeneID Gene Rank
CTNND1 797.0
PARD6A 556.5
SDK2 0.5
PARD6B -546.0
CDH24 -613.0
CLDN1 -1469.0
CLDN12 -1949.0
ANG -3052.5
F11R -4158.0
PRKCI -5240.0
CTNNB1 -6204.0
MPP5 -7953.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTNND1 797.0
PARD6A 556.5
SDK2 0.5
PARD6B -546.0
CDH24 -613.0
CLDN1 -1469.0
CLDN12 -1949.0
ANG -3052.5
F11R -4158.0
PRKCI -5240.0
CTNNB1 -6204.0
MPP5 -7953.0


Generation of second messenger molecules

Generation of second messenger molecules
362
set Generation of second messenger molecules
setSize 12
pANOVA 0.0606
s.dist 0.313
p.adjustANOVA 0.343



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD247 729.0
GRAP2 0.5
ITK 0.5
PAK1 -1126.0
PLCG1 -1151.0
LCK -1992.0
EVL -2347.0
VASP -3111.0
NCK1 -3899.0
PAK2 -5011.0
PLCG2 -5781.0
LCP2 -6236.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD247 729.0
GRAP2 0.5
ITK 0.5
PAK1 -1126.0
PLCG1 -1151.0
LCK -1992.0
EVL -2347.0
VASP -3111.0
NCK1 -3899.0
PAK2 -5011.0
PLCG2 -5781.0
LCP2 -6236.0


Meiosis

Meiosis
518
set Meiosis
setSize 39
pANOVA 0.000785
s.dist -0.311
p.adjustANOVA 0.051



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATM -8945.5
TINF2 -8852.0
BRCA1 -8797.5
MSH5 -8789.0
ATR -8697.0
TERF2 -8593.0
DIDO1 -8591.0
BRCA2 -8433.0
HSPA2 -8393.0
RBBP8 -8270.0
RAD51 -8226.0
RAD21 -8077.0
PSMC3IP -8067.0
SMC3 -8017.0
MND1 -7741.0
BLM -7501.0
REC8 -7385.0
TOP3A -7020.5
LMNB1 -6686.0
RPA3 -6328.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATM -8945.5
TINF2 -8852.0
BRCA1 -8797.5
MSH5 -8789.0
ATR -8697.0
TERF2 -8593.0
DIDO1 -8591.0
BRCA2 -8433.0
HSPA2 -8393.0
RBBP8 -8270.0
RAD51 -8226.0
RAD21 -8077.0
PSMC3IP -8067.0
SMC3 -8017.0
MND1 -7741.0
BLM -7501.0
REC8 -7385.0
TOP3A -7020.5
LMNB1 -6686.0
RPA3 -6328.0
CDK4 -6073.0
UBE2I -5674.0
MLH3 -5573.0
TERF2IP -5172.5
DMC1 -4318.0
STAG1 -4295.0
TERF1 -3820.0
H2AFX -3494.0
RPA1 -3377.5
CDK2 -3323.5
SYCE2 -2919.0
SYNE1 -2672.0
RAD50 -1967.0
NBN -1658.0
SYNE2 -1193.0
STAG3 -675.5
LMNA 0.5
SMC1B 396.5
ACD 556.5


Prostacyclin signalling through prostacyclin receptor

Prostacyclin signalling through prostacyclin receptor
717
set Prostacyclin signalling through prostacyclin receptor
setSize 10
pANOVA 0.0892
s.dist 0.31
p.adjustANOVA 0.394



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GNGT2 0.5
GNAS -956.0
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNG4 869.0
GNG2 620.0
GNG12 0.5
GNGT2 0.5
GNAS -956.0
GNG5 -3127.5
GNB1 -4107.0
GNB5 -4674.0
GNG3 -5234.0
GNB2 -8449.0


Assembly and cell surface presentation of NMDA receptors

Assembly and cell surface presentation of NMDA receptors
63
set Assembly and cell surface presentation of NMDA receptors
setSize 12
pANOVA 0.0637
s.dist 0.309
p.adjustANOVA 0.35



Top enriched genes

Top 20 genes
GeneID Gene Rank
DLG1 633.0
NBEA 346.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
APBA1 -992.0
KIF17 -1599.0
DLG4 -3314.0
LIN7B -4774.0
LIN7C -5707.5
CAMK2D -6176.0
DLG2 -8562.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLG1 633.0
NBEA 346.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
APBA1 -992.0
KIF17 -1599.0
DLG4 -3314.0
LIN7B -4774.0
LIN7C -5707.5
CAMK2D -6176.0
DLG2 -8562.0


Resolution of D-loop Structures through Holliday Junction Intermediates

Resolution of D-loop Structures through Holliday Junction Intermediates
860
set Resolution of D-loop Structures through Holliday Junction Intermediates
setSize 24
pANOVA 0.00901
s.dist -0.308
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
MUS81 -8759.0
GEN1 -8523.5
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
KAT5 -8198.0
XRCC3 -7805.5
BLM -7501.0
RMI1 -7389.5
DNA2 -7266.0
TOP3A -7020.5
EXO1 -6078.0
XRCC2 -4285.0
WRN -4029.5
RAD51AP1 -3956.5
EME2 -2554.5
EME1 -2531.5
RAD50 -1967.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
MUS81 -8759.0
GEN1 -8523.5
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
KAT5 -8198.0
XRCC3 -7805.5
BLM -7501.0
RMI1 -7389.5
DNA2 -7266.0
TOP3A -7020.5
EXO1 -6078.0
XRCC2 -4285.0
WRN -4029.5
RAD51AP1 -3956.5
EME2 -2554.5
EME1 -2531.5
RAD50 -1967.0
NBN -1658.0
PALB2 -839.5
BARD1 -363.0
BRIP1 349.0


mRNA 3’-end processing

mRNA 3’-end processing
1147
set mRNA 3’-end processing
setSize 30
pANOVA 0.00418
s.dist -0.302
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLP1 -8773.0
NUDT21 -8451.5
CSTF1 -8202.5
RNPS1 -8181.0
CPSF2 -7963.5
PAPOLA -7720.0
CPSF1 -7599.0
SYMPK -7355.0
CASC3 -7256.0
U2AF1 -7242.0
SLU7 -6879.0
THOC1 -6676.0
THOC7 -6528.0
U2AF1L4 -6394.5
NCBP1 -6163.5
FYTTD1 -5944.0
CPSF3 -5893.5
THOC6 -5502.5
FIP1L1 -5106.0
PABPN1 -4971.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLP1 -8773.0
NUDT21 -8451.5
CSTF1 -8202.5
RNPS1 -8181.0
CPSF2 -7963.5
PAPOLA -7720.0
CPSF1 -7599.0
SYMPK -7355.0
CASC3 -7256.0
U2AF1 -7242.0
SLU7 -6879.0
THOC1 -6676.0
THOC7 -6528.0
U2AF1L4 -6394.5
NCBP1 -6163.5
FYTTD1 -5944.0
CPSF3 -5893.5
THOC6 -5502.5
FIP1L1 -5106.0
PABPN1 -4971.0
THOC5 -4789.0
POLDIP3 -4636.0
CPSF4 -4246.5
SRRM1 -3818.0
WDR33 -3644.0
EIF4A3 -2552.0
CDC40 -1427.5
NCBP2 -1030.5
U2AF2 -492.0
CPSF6 0.5


Long-term potentiation

Long-term potentiation
499
set Long-term potentiation
setSize 10
pANOVA 0.0989
s.dist 0.301
p.adjustANOVA 0.41



Top enriched genes

Top 20 genes
GeneID Gene Rank
DLG1 633.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
CALM1 -817.0
DLG4 -3314.0
NRGN -3353.0
SRC -3915.0
CAMK2D -6176.0
DLG2 -8562.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLG1 633.0
CAMK2G 0.5
GRIN1 0.5
GRIN2D 0.5
CALM1 -817.0
DLG4 -3314.0
NRGN -3353.0
SRC -3915.0
CAMK2D -6176.0
DLG2 -8562.0


Myogenesis

Myogenesis
575
set Myogenesis
setSize 13
pANOVA 0.061
s.dist -0.3
p.adjustANOVA 0.343



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK14 -8225.0
CDC42 -8026.0
MEF2D -7214.0
ABL1 -6532.0
CTNNB1 -6204.0
BNIP2 -6168.0
MAP2K6 -5905.0
MEF2A -5468.0
TCF12 -5416.0
NEO1 -4706.0
SPAG9 -4461.0
CDON -3260.0
TCF3 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK14 -8225.0
CDC42 -8026.0
MEF2D -7214.0
ABL1 -6532.0
CTNNB1 -6204.0
BNIP2 -6168.0
MAP2K6 -5905.0
MEF2A -5468.0
TCF12 -5416.0
NEO1 -4706.0
SPAG9 -4461.0
CDON -3260.0
TCF3 0.5


Presynaptic phase of homologous DNA pairing and strand exchange

Presynaptic phase of homologous DNA pairing and strand exchange
708
set Presynaptic phase of homologous DNA pairing and strand exchange
setSize 32
pANOVA 0.00367
s.dist -0.297
p.adjustANOVA 0.117



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
ATR -8697.0
RFC5 -8619.0
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
KAT5 -8198.0
RFC3 -8030.0
RAD9B -7770.5
BLM -7501.0
RMI1 -7389.5
DNA2 -7266.0
TOP3A -7020.5
RAD1 -6683.5
RPA3 -6328.0
EXO1 -6078.0
RFC2 -5672.0
HUS1 -5490.0
RAD17 -5393.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATM -8945.5
BRCA1 -8797.5
ATR -8697.0
RFC5 -8619.0
BRCA2 -8433.0
RBBP8 -8270.0
RAD51 -8226.0
KAT5 -8198.0
RFC3 -8030.0
RAD9B -7770.5
BLM -7501.0
RMI1 -7389.5
DNA2 -7266.0
TOP3A -7020.5
RAD1 -6683.5
RPA3 -6328.0
EXO1 -6078.0
RFC2 -5672.0
HUS1 -5490.0
RAD17 -5393.5
XRCC2 -4285.0
WRN -4029.5
RPA1 -3377.5
RAD9A -3132.0
TOPBP1 -3108.0
ATRIP -2471.0
CHEK1 -2304.0
RAD50 -1967.0
NBN -1658.0
RFC4 -456.0
BARD1 -363.0
BRIP1 349.0


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.2.4    GGally_2.1.2     ggplot2_3.3.6    reshape2_1.4.4  
##  [5] beeswarm_0.4.0   gplots_3.1.3     gtools_3.9.2     tibble_3.1.7    
##  [9] echarts4r_0.4.3  mitch_1.4.1      eulerr_6.1.1     kableExtra_1.3.4
## [13] dplyr_1.0.9     
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.8.3       svglite_2.1.0      rprojroot_2.0.3    assertthat_0.2.1  
##  [5] digest_0.6.29      utf8_1.2.2         mime_0.12          R6_2.5.1          
##  [9] plyr_1.8.7         evaluate_0.15      httr_1.4.3         highr_0.9         
## [13] pillar_1.7.0       rlang_1.0.2        rstudioapi_0.13    jquerylib_0.1.4   
## [17] rmarkdown_2.14     desc_1.4.1         webshot_0.5.3      stringr_1.4.0     
## [21] htmlwidgets_1.5.4  munsell_0.5.0      shiny_1.7.1        compiler_4.2.0    
## [25] httpuv_1.6.5       xfun_0.30          pkgconfig_2.0.3    systemfonts_1.0.4 
## [29] htmltools_0.5.2    tidyselect_1.1.2   gridExtra_2.3      reshape_0.8.9     
## [33] fansi_1.0.3        viridisLite_0.4.0  withr_2.5.0        crayon_1.5.1      
## [37] later_1.3.0        brio_1.1.3         bitops_1.0-7       MASS_7.3-57       
## [41] grid_4.2.0         jsonlite_1.8.0     xtable_1.8-4       gtable_0.3.0      
## [45] lifecycle_1.0.1    DBI_1.1.2          magrittr_2.0.3     scales_1.2.0      
## [49] KernSmooth_2.23-20 cli_3.3.0          stringi_1.7.6      promises_1.2.0.1  
## [53] testthat_3.1.4     xml2_1.3.3         bslib_0.3.1        ellipsis_0.3.2    
## [57] generics_0.1.2     vctrs_0.4.1        RColorBrewer_1.1-3 tools_4.2.0       
## [61] glue_1.6.2         purrr_0.3.4        fastmap_1.1.0      yaml_2.3.5        
## [65] colorspace_2.0-3   caTools_1.18.2     rvest_1.0.2        knitr_1.39        
## [69] sass_0.4.1

END of report