date generated: 2024-01-11

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
A1BG -0.1281221
A1BG-AS1 -0.1265037
A1CF -0.2257970
A2M -0.0016135
A2M-AS1 1.3166603
A2ML1 -0.3595390

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2656
num_genes_in_profile 21625
duplicated_genes_present 0
num_profile_genes_in_sets 10357
num_profile_genes_not_in_sets 11268

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways.gmt
Gene set metrics
Gene sets metrics
num_genesets 2656
num_genesets_excluded 1052
num_genesets_included 1604

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 5 1.76e-03 0.808 1.71e-02
Regulation of gene expression in early pancreatic precursor cells 8 1.42e-04 0.777 2.93e-03
Formation of lateral plate mesoderm 5 3.27e-03 0.760 2.70e-02
Free fatty acid receptors 5 4.13e-03 0.740 3.18e-02
Formation of intermediate mesoderm 8 1.73e-03 0.639 1.69e-02
Formation of the ureteric bud 21 5.43e-07 0.631 1.96e-05
Thyroxine biosynthesis 10 5.98e-04 0.627 8.25e-03
Transcriptional regulation of testis differentiation 12 2.05e-04 0.619 3.97e-03
Acrosome Reaction and Sperm:Oocyte Membrane Binding 6 1.17e-02 -0.594 7.01e-02
Electric Transmission Across Gap Junctions 5 2.16e-02 0.593 1.14e-01
Transmission across Electrical Synapses 5 2.16e-02 0.593 1.14e-01
Defective LFNG causes SCDO3 5 2.46e-02 0.580 1.25e-01
Formation of the anterior neural plate 10 1.79e-03 0.570 1.71e-02
Cobalamin (Cbl) metabolism 7 9.39e-03 -0.567 6.02e-02
Specification of the neural plate border 16 9.64e-05 0.563 2.10e-03
Hyaluronan biosynthesis and export 5 3.10e-02 0.557 1.47e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 9 4.40e-03 0.548 3.33e-02
Adrenoceptors 9 4.43e-03 0.548 3.34e-02
Vasopressin-like receptors 5 3.46e-02 0.546 1.59e-01
Kidney development 45 2.62e-10 0.544 2.52e-08
CREB3 factors activate genes 8 8.62e-03 -0.536 5.65e-02
Alpha-oxidation of phytanate 6 2.32e-02 -0.535 1.20e-01
Dopamine receptors 5 4.03e-02 0.530 1.74e-01
Nephron development 13 1.15e-03 0.521 1.24e-02
Neurotransmitter clearance 9 8.57e-03 0.506 5.65e-02
Erythropoietin activates STAT5 7 2.19e-02 0.500 1.14e-01
Metal sequestration by antimicrobial proteins 5 5.41e-02 -0.497 2.16e-01
Vitamins 6 3.52e-02 0.497 1.61e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 7.59e-03 0.487 5.12e-02
Prednisone ADME 9 1.24e-02 0.481 7.27e-02
Signaling by RNF43 mutants 8 1.96e-02 0.476 1.06e-01
Recycling of eIF2:GDP 7 2.93e-02 -0.476 1.42e-01
Sensing of DNA Double Strand Breaks 6 4.48e-02 -0.473 1.87e-01
Organic anion transport 5 6.93e-02 -0.469 2.55e-01
Ligand-receptor interactions 8 2.37e-02 0.462 1.22e-01
Defective F9 activation 5 7.82e-02 0.455 2.77e-01
Establishment of Sister Chromatid Cohesion 9 1.93e-02 -0.450 1.05e-01
Activation of TRKA receptors 6 5.80e-02 0.447 2.25e-01
Calcitonin-like ligand receptors 10 1.50e-02 0.444 8.59e-02
Folding of actin by CCT/TriC 10 1.57e-02 -0.441 8.82e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 8.92e-02 0.439 3.02e-01
Tandem pore domain potassium channels 12 1.01e-02 0.429 6.31e-02
CD22 mediated BCR regulation 5 9.81e-02 0.427 3.20e-01
Mitotic Telophase/Cytokinesis 11 1.58e-02 -0.420 8.82e-02
Phosphorylation of Emi1 6 7.61e-02 -0.418 2.72e-01
SRP-dependent cotranslational protein targeting to membrane 105 1.29e-13 -0.418 2.58e-11
Formation of the nephric duct 17 3.07e-03 0.415 2.60e-02
Cellular response to mitochondrial stress 8 4.24e-02 -0.414 1.80e-01
Formation of xylulose-5-phosphate 5 1.09e-01 -0.414 3.43e-01
Cohesin Loading onto Chromatin 8 4.44e-02 -0.410 1.87e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 5 1.76e-03 8.08e-01 1.71e-02
Regulation of gene expression in early pancreatic precursor cells 8 1.42e-04 7.77e-01 2.93e-03
Formation of lateral plate mesoderm 5 3.27e-03 7.60e-01 2.70e-02
Free fatty acid receptors 5 4.13e-03 7.40e-01 3.18e-02
Formation of intermediate mesoderm 8 1.73e-03 6.39e-01 1.69e-02
Formation of the ureteric bud 21 5.43e-07 6.31e-01 1.96e-05
Thyroxine biosynthesis 10 5.98e-04 6.27e-01 8.25e-03
Transcriptional regulation of testis differentiation 12 2.05e-04 6.19e-01 3.97e-03
Acrosome Reaction and Sperm:Oocyte Membrane Binding 6 1.17e-02 -5.94e-01 7.01e-02
Electric Transmission Across Gap Junctions 5 2.16e-02 5.93e-01 1.14e-01
Transmission across Electrical Synapses 5 2.16e-02 5.93e-01 1.14e-01
Defective LFNG causes SCDO3 5 2.46e-02 5.80e-01 1.25e-01
Formation of the anterior neural plate 10 1.79e-03 5.70e-01 1.71e-02
Cobalamin (Cbl) metabolism 7 9.39e-03 -5.67e-01 6.02e-02
Specification of the neural plate border 16 9.64e-05 5.63e-01 2.10e-03
Hyaluronan biosynthesis and export 5 3.10e-02 5.57e-01 1.47e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 9 4.40e-03 5.48e-01 3.33e-02
Adrenoceptors 9 4.43e-03 5.48e-01 3.34e-02
Vasopressin-like receptors 5 3.46e-02 5.46e-01 1.59e-01
Kidney development 45 2.62e-10 5.44e-01 2.52e-08
CREB3 factors activate genes 8 8.62e-03 -5.36e-01 5.65e-02
Alpha-oxidation of phytanate 6 2.32e-02 -5.35e-01 1.20e-01
Dopamine receptors 5 4.03e-02 5.30e-01 1.74e-01
Nephron development 13 1.15e-03 5.21e-01 1.24e-02
Neurotransmitter clearance 9 8.57e-03 5.06e-01 5.65e-02
Erythropoietin activates STAT5 7 2.19e-02 5.00e-01 1.14e-01
Metal sequestration by antimicrobial proteins 5 5.41e-02 -4.97e-01 2.16e-01
Vitamins 6 3.52e-02 4.97e-01 1.61e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 7.59e-03 4.87e-01 5.12e-02
Prednisone ADME 9 1.24e-02 4.81e-01 7.27e-02
Signaling by RNF43 mutants 8 1.96e-02 4.76e-01 1.06e-01
Recycling of eIF2:GDP 7 2.93e-02 -4.76e-01 1.42e-01
Sensing of DNA Double Strand Breaks 6 4.48e-02 -4.73e-01 1.87e-01
Organic anion transport 5 6.93e-02 -4.69e-01 2.55e-01
Ligand-receptor interactions 8 2.37e-02 4.62e-01 1.22e-01
Defective F9 activation 5 7.82e-02 4.55e-01 2.77e-01
Establishment of Sister Chromatid Cohesion 9 1.93e-02 -4.50e-01 1.05e-01
Activation of TRKA receptors 6 5.80e-02 4.47e-01 2.25e-01
Calcitonin-like ligand receptors 10 1.50e-02 4.44e-01 8.59e-02
Folding of actin by CCT/TriC 10 1.57e-02 -4.41e-01 8.82e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 8.92e-02 4.39e-01 3.02e-01
Tandem pore domain potassium channels 12 1.01e-02 4.29e-01 6.31e-02
CD22 mediated BCR regulation 5 9.81e-02 4.27e-01 3.20e-01
Mitotic Telophase/Cytokinesis 11 1.58e-02 -4.20e-01 8.82e-02
Phosphorylation of Emi1 6 7.61e-02 -4.18e-01 2.72e-01
SRP-dependent cotranslational protein targeting to membrane 105 1.29e-13 -4.18e-01 2.58e-11
Formation of the nephric duct 17 3.07e-03 4.15e-01 2.60e-02
Cellular response to mitochondrial stress 8 4.24e-02 -4.14e-01 1.80e-01
Formation of xylulose-5-phosphate 5 1.09e-01 -4.14e-01 3.43e-01
Cohesin Loading onto Chromatin 8 4.44e-02 -4.10e-01 1.87e-01
HDL clearance 5 1.12e-01 4.10e-01 3.46e-01
Regulation of gene expression in beta cells 21 1.22e-03 4.08e-01 1.29e-02
Activation of caspases through apoptosome-mediated cleavage 5 1.15e-01 -4.07e-01 3.51e-01
Terminal pathway of complement 8 4.75e-02 -4.05e-01 1.97e-01
Sema4D mediated inhibition of cell attachment and migration 8 4.82e-02 -4.03e-01 1.99e-01
Formation of the posterior neural plate 10 2.75e-02 4.03e-01 1.34e-01
Serotonin receptors 11 2.16e-02 4.00e-01 1.14e-01
FGFR3 mutant receptor activation 11 2.18e-02 3.99e-01 1.14e-01
Signaling by activated point mutants of FGFR3 11 2.18e-02 3.99e-01 1.14e-01
Activation of C3 and C5 6 9.23e-02 3.97e-01 3.08e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 6.96e-02 -3.96e-01 2.55e-01
SARS-CoV-1 modulates host translation machinery 33 8.22e-05 -3.96e-01 1.81e-03
Eukaryotic Translation Termination 86 2.32e-10 -3.95e-01 2.44e-08
G2/M DNA replication checkpoint 5 1.27e-01 -3.94e-01 3.77e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.13e-03 -3.92e-01 3.70e-02
Regulation of beta-cell development 41 1.53e-05 3.90e-01 4.37e-04
Activation of the TFAP2 (AP-2) family of transcription factors 11 2.53e-02 3.90e-01 1.27e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 7 7.44e-02 3.89e-01 2.68e-01
PINK1-PRKN Mediated Mitophagy 21 2.00e-03 -3.89e-01 1.86e-02
Amine ligand-binding receptors 40 2.03e-05 3.89e-01 5.42e-04
Phase 4 - resting membrane potential 19 3.33e-03 3.89e-01 2.73e-02
Viral mRNA Translation 83 9.29e-10 -3.89e-01 7.64e-08
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.55e-03 -3.88e-01 3.94e-02
Phospholipase C-mediated cascade; FGFR3 12 2.01e-02 3.88e-01 1.08e-01
Condensation of Prometaphase Chromosomes 11 2.74e-02 -3.84e-01 1.34e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 10 3.59e-02 3.83e-01 1.63e-01
Voltage gated Potassium channels 42 1.91e-05 3.81e-01 5.23e-04
Polo-like kinase mediated events 16 8.63e-03 -3.79e-01 5.65e-02
NGF-independant TRKA activation 5 1.42e-01 3.79e-01 3.99e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 1.10e-01 3.77e-01 3.45e-01
Signaling by MAPK mutants 6 1.11e-01 -3.76e-01 3.46e-01
IkBA variant leads to EDA-ID 6 1.12e-01 -3.75e-01 3.46e-01
AMPK inhibits chREBP transcriptional activation activity 8 6.63e-02 3.75e-01 2.47e-01
Peptide chain elongation 83 4.06e-09 -3.73e-01 2.90e-07
SMAC (DIABLO) binds to IAPs 6 1.14e-01 -3.72e-01 3.50e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 6 1.14e-01 -3.72e-01 3.50e-01
SMAC, XIAP-regulated apoptotic response 6 1.14e-01 -3.72e-01 3.50e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 2.57e-02 3.72e-01 1.28e-01
Transcriptional regulation of pluripotent stem cells 28 6.64e-04 3.72e-01 8.68e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 88 2.04e-09 -3.70e-01 1.57e-07
Selenocysteine synthesis 86 3.94e-09 -3.67e-01 2.90e-07
Regulation of TP53 Activity through Association with Co-factors 14 1.76e-02 3.66e-01 9.73e-02
RUNX1 regulates expression of components of tight junctions 5 1.57e-01 3.65e-01 4.27e-01
Hydrolysis of LPC 9 5.82e-02 -3.65e-01 2.25e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 4.00e-04 -3.62e-01 6.44e-03
Nuclear Pore Complex (NPC) Disassembly 36 1.75e-04 -3.61e-01 3.47e-03
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.30e-04 -3.60e-01 6.67e-03
p38MAPK events 13 2.49e-02 -3.59e-01 1.26e-01
Influenza Viral RNA Transcription and Replication 130 1.46e-12 -3.59e-01 2.43e-10
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 1.61e-02 3.59e-01 8.98e-02
Eukaryotic Translation Elongation 87 7.45e-09 -3.58e-01 4.52e-07
Formation of axial mesoderm 14 2.03e-02 3.58e-01 1.09e-01
Melanin biosynthesis 5 1.68e-01 3.56e-01 4.44e-01
Rev-mediated nuclear export of HIV RNA 35 2.73e-04 -3.55e-01 4.91e-03
Choline catabolism 6 1.32e-01 3.55e-01 3.82e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 5.44e-04 -3.53e-01 7.83e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 5.44e-04 -3.53e-01 7.83e-03
Vitamin C (ascorbate) metabolism 8 8.51e-02 -3.52e-01 2.91e-01
Synthesis of Ketone Bodies 8 8.63e-02 3.50e-01 2.95e-01
Interactions of Rev with host cellular proteins 37 2.32e-04 -3.50e-01 4.37e-03
Export of Viral Ribonucleoproteins from Nucleus 33 5.19e-04 -3.49e-01 7.65e-03
Metabolism of amine-derived hormones 17 1.32e-02 3.47e-01 7.64e-02
Tachykinin receptors bind tachykinins 5 1.80e-01 3.46e-01 4.66e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 3.80e-02 3.46e-01 1.68e-01
SUMOylation of SUMOylation proteins 35 3.98e-04 -3.46e-01 6.44e-03
Nuclear import of Rev protein 34 4.84e-04 -3.46e-01 7.39e-03
Expression and translocation of olfactory receptors 317 7.20e-26 3.43e-01 1.44e-22
Cation-coupled Chloride cotransporters 7 1.16e-01 3.43e-01 3.54e-01
GLI proteins bind promoters of Hh responsive genes to promote transcription 7 1.17e-01 3.42e-01 3.56e-01
Formation of ATP by chemiosmotic coupling 16 1.85e-02 -3.40e-01 1.02e-01
Regulation of CDH11 mRNA translation by microRNAs 11 5.09e-02 3.40e-01 2.07e-01
Creatine metabolism 8 9.69e-02 3.39e-01 3.19e-01
Maturation of hRSV A proteins 13 3.46e-02 -3.38e-01 1.59e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 94 1.47e-08 -3.38e-01 8.41e-07
HS-GAG biosynthesis 28 2.15e-03 3.35e-01 1.96e-02
Vpr-mediated nuclear import of PICs 34 7.37e-04 -3.34e-01 9.38e-03
Nuclear Envelope Breakdown 52 3.12e-05 -3.34e-01 7.90e-04
Ficolins bind to repetitive carbohydrate structures on the target cell surface 5 1.96e-01 -3.34e-01 4.90e-01
Formation of a pool of free 40S subunits 93 3.01e-08 -3.32e-01 1.47e-06
RUNX1 regulates estrogen receptor mediated transcription 6 1.59e-01 3.32e-01 4.31e-01
Olfactory Signaling Pathway 324 8.72e-25 3.32e-01 8.72e-22
FGFR2c ligand binding and activation 12 4.66e-02 3.32e-01 1.94e-01
Influenza Infection 149 2.71e-12 -3.32e-01 4.17e-10
RUNX2 regulates chondrocyte maturation 5 2.00e-01 3.31e-01 4.92e-01
Transport of the SLBP Dependant Mature mRNA 36 6.10e-04 -3.30e-01 8.34e-03
Transport of the SLBP independent Mature mRNA 35 7.35e-04 -3.30e-01 9.38e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 107 4.56e-09 -3.28e-01 2.95e-07
Nonsense-Mediated Decay (NMD) 107 4.56e-09 -3.28e-01 2.95e-07
RHO GTPases activate KTN1 11 5.97e-02 -3.28e-01 2.30e-01
Abacavir ADME 9 8.88e-02 3.28e-01 3.02e-01
Triglyceride biosynthesis 11 6.03e-02 -3.27e-01 2.31e-01
Mitophagy 27 3.28e-03 -3.27e-01 2.70e-02
PI3K events in ERBB4 signaling 10 7.46e-02 3.26e-01 2.69e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 2.42e-02 -3.25e-01 1.24e-01
Passive transport by Aquaporins 13 4.26e-02 -3.25e-01 1.81e-01
Respiratory electron transport 90 1.11e-07 -3.24e-01 4.63e-06
Cap-dependent Translation Initiation 110 4.72e-09 -3.23e-01 2.95e-07
Eukaryotic Translation Initiation 110 4.72e-09 -3.23e-01 2.95e-07
GTP hydrolysis and joining of the 60S ribosomal subunit 103 1.47e-08 -3.23e-01 8.41e-07
Hyaluronan uptake and degradation 12 5.32e-02 -3.22e-01 2.15e-01
ERBB2 Activates PTK6 Signaling 13 4.46e-02 3.22e-01 1.87e-01
RIP-mediated NFkB activation via ZBP1 16 2.59e-02 -3.22e-01 1.28e-01
L13a-mediated translational silencing of Ceruloplasmin expression 102 2.11e-08 -3.21e-01 1.11e-06
Purine ribonucleoside monophosphate biosynthesis 9 9.57e-02 -3.21e-01 3.16e-01
HDR through MMEJ (alt-NHEJ) 12 5.54e-02 -3.19e-01 2.19e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 6 1.76e-01 -3.19e-01 4.60e-01
Viral Messenger RNA Synthesis 44 2.53e-04 -3.19e-01 4.64e-03
Interactions of Vpr with host cellular proteins 35 1.10e-03 -3.19e-01 1.22e-02
mRNA decay by 3’ to 5’ exoribonuclease 16 2.75e-02 -3.18e-01 1.34e-01
Classical antibody-mediated complement activation 6 1.78e-01 -3.17e-01 4.64e-01
SARS-CoV-2 modulates host translation machinery 45 2.29e-04 -3.17e-01 4.36e-03
Regulation of CDH11 gene transcription 10 8.24e-02 3.17e-01 2.87e-01
CREB phosphorylation 6 1.79e-01 -3.17e-01 4.64e-01
Cardiogenesis 26 5.15e-03 3.17e-01 3.70e-02
Creation of C4 and C2 activators 14 4.02e-02 -3.17e-01 1.74e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 2.84e-02 -3.16e-01 1.38e-01
Lectin pathway of complement activation 8 1.22e-01 -3.16e-01 3.66e-01
Abacavir transmembrane transport 5 2.23e-01 3.15e-01 5.24e-01
FGFRL1 modulation of FGFR1 signaling 13 5.00e-02 3.14e-01 2.05e-01
Synthesis of GDP-mannose 5 2.24e-01 -3.14e-01 5.25e-01
PI-3K cascade:FGFR3 17 2.55e-02 3.13e-01 1.28e-01
Regulation of NPAS4 mRNA translation 9 1.04e-01 3.13e-01 3.33e-01
Release of apoptotic factors from the mitochondria 6 1.88e-01 -3.10e-01 4.78e-01
Release of Hh-Np from the secreting cell 8 1.29e-01 3.10e-01 3.80e-01
FGFR3 ligand binding and activation 12 6.38e-02 3.09e-01 2.42e-01
FGFR3c ligand binding and activation 12 6.38e-02 3.09e-01 2.42e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 4.92e-04 -3.07e-01 7.45e-03
Transport of Mature mRNA Derived from an Intronless Transcript 42 5.92e-04 -3.06e-01 8.22e-03
Defective factor IX causes hemophilia B 7 1.61e-01 3.06e-01 4.35e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 111 2.56e-08 -3.06e-01 1.31e-06
Depolymerization of the Nuclear Lamina 14 4.85e-02 -3.04e-01 2.00e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.03e-02 -3.04e-01 1.45e-01
Erythrocytes take up oxygen and release carbon dioxide 8 1.39e-01 -3.02e-01 3.95e-01
Crosslinking of collagen fibrils 16 3.70e-02 3.01e-01 1.65e-01
Activation of Matrix Metalloproteinases 30 4.35e-03 3.01e-01 3.31e-02
Activated point mutants of FGFR2 16 3.75e-02 3.00e-01 1.66e-01
Biosynthesis of maresin-like SPMs 6 2.03e-01 3.00e-01 4.95e-01
Sulfide oxidation to sulfate 5 2.46e-01 3.00e-01 5.50e-01
Synthesis of PIPs at the ER membrane 5 2.46e-01 -2.99e-01 5.50e-01
Translation 277 1.14e-17 -2.99e-01 3.81e-15
Transport of Mature mRNA derived from an Intron-Containing Transcript 69 1.83e-05 -2.98e-01 5.08e-04
Phospholipase C-mediated cascade; FGFR2 17 3.34e-02 2.98e-01 1.56e-01
NFE2L2 regulating inflammation associated genes 5 2.49e-01 2.98e-01 5.53e-01
Physiological factors 14 5.41e-02 2.97e-01 2.16e-01
RHOBTB3 ATPase cycle 8 1.46e-01 2.97e-01 4.08e-01
Transcription of E2F targets under negative control by DREAM complex 19 2.55e-02 -2.96e-01 1.28e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 38 1.61e-03 2.96e-01 1.61e-02
Defective factor VIII causes hemophilia A 5 2.52e-01 -2.96e-01 5.56e-01
Regulation of HMOX1 expression and activity 5 2.53e-01 -2.95e-01 5.56e-01
p75NTR negatively regulates cell cycle via SC1 6 2.13e-01 2.94e-01 5.10e-01
ERKs are inactivated 13 6.77e-02 -2.93e-01 2.51e-01
Activated NTRK2 signals through PI3K 7 1.80e-01 2.92e-01 4.67e-01
FGFR4 ligand binding and activation 13 6.93e-02 2.91e-01 2.55e-01
ZBP1(DAI) mediated induction of type I IFNs 20 2.43e-02 -2.91e-01 1.24e-01
Postmitotic nuclear pore complex (NPC) reformation 27 8.95e-03 -2.91e-01 5.76e-02
ERK/MAPK targets 20 2.46e-02 -2.90e-01 1.25e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 2.19e-01 2.90e-01 5.18e-01
Urea cycle 9 1.33e-01 -2.89e-01 3.84e-01
Formation of annular gap junctions 11 9.69e-02 -2.89e-01 3.19e-01
Activation of the AP-1 family of transcription factors 10 1.14e-01 -2.89e-01 3.49e-01
Phospholipase C-mediated cascade; FGFR4 14 6.14e-02 2.89e-01 2.35e-01
Transport of Mature Transcript to Cytoplasm 78 1.09e-05 -2.88e-01 3.19e-04
Diseases associated with visual transduction 11 9.83e-02 2.88e-01 3.20e-01
Diseases of the neuronal system 11 9.83e-02 2.88e-01 3.20e-01
Retinoid cycle disease events 11 9.83e-02 2.88e-01 3.20e-01
SARS-CoV-2 modulates autophagy 11 9.84e-02 -2.88e-01 3.20e-01
Vitamin B5 (pantothenate) metabolism 19 3.00e-02 -2.88e-01 1.44e-01
MAP2K and MAPK activation 38 2.19e-03 -2.87e-01 1.98e-02
NS1 Mediated Effects on Host Pathways 41 1.48e-03 -2.87e-01 1.49e-02
Endosomal/Vacuolar pathway 10 1.17e-01 2.86e-01 3.56e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 2.25e-01 -2.86e-01 5.25e-01
Lysosphingolipid and LPA receptors 14 6.44e-02 2.85e-01 2.43e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 8.23e-04 -2.85e-01 9.92e-03
IRF3 mediated activation of type 1 IFN 5 2.70e-01 -2.85e-01 5.74e-01
Phospholipase C-mediated cascade: FGFR1 16 4.91e-02 2.84e-01 2.01e-01
ChREBP activates metabolic gene expression 8 1.64e-01 2.84e-01 4.41e-01
Signalling to p38 via RIT and RIN 5 2.72e-01 2.83e-01 5.75e-01
SUMOylation of DNA replication proteins 46 8.81e-04 -2.83e-01 1.04e-02
Citric acid cycle (TCA cycle) 21 2.46e-02 -2.83e-01 1.25e-01
Resolution of D-Loop Structures 33 4.89e-03 -2.83e-01 3.58e-02
Formation of the ternary complex, and subsequently, the 43S complex 45 1.04e-03 -2.83e-01 1.17e-02
Mitochondrial translation elongation 87 5.19e-06 -2.83e-01 1.65e-04
Protein hydroxylation 17 4.40e-02 -2.82e-01 1.86e-01
Mitochondrial translation 93 2.56e-06 -2.82e-01 8.68e-05
Complex I biogenesis 49 6.40e-04 -2.82e-01 8.64e-03
Post-transcriptional silencing by small RNAs 7 1.97e-01 2.82e-01 4.90e-01
Mitochondrial translation initiation 87 5.67e-06 -2.81e-01 1.77e-04
CaMK IV-mediated phosphorylation of CREB 10 1.25e-01 -2.80e-01 3.73e-01
G0 and Early G1 27 1.17e-02 -2.80e-01 7.01e-02
Regulation of ornithine decarboxylase (ODC) 50 6.14e-04 -2.80e-01 8.34e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF 42 1.80e-03 -2.78e-01 1.71e-02
Signaling by RAS mutants 42 1.80e-03 -2.78e-01 1.71e-02
Signaling by moderate kinase activity BRAF mutants 42 1.80e-03 -2.78e-01 1.71e-02
Signaling downstream of RAS mutants 42 1.80e-03 -2.78e-01 1.71e-02
Defects in cobalamin (B12) metabolism 13 8.31e-02 -2.78e-01 2.88e-01
Vitamin B1 (thiamin) metabolism 5 2.84e-01 -2.77e-01 5.84e-01
Vpu mediated degradation of CD4 51 6.45e-04 -2.76e-01 8.66e-03
Metabolism of non-coding RNA 52 5.73e-04 -2.76e-01 8.06e-03
snRNP Assembly 52 5.73e-04 -2.76e-01 8.06e-03
Mitochondrial translation termination 87 8.73e-06 -2.76e-01 2.64e-04
Calcineurin activates NFAT 9 1.53e-01 -2.75e-01 4.19e-01
RA biosynthesis pathway 22 2.56e-02 2.75e-01 1.28e-01
MAPK targets/ Nuclear events mediated by MAP kinases 29 1.05e-02 -2.74e-01 6.51e-02
Metabolism of polyamines 56 3.81e-04 -2.74e-01 6.40e-03
Signaling by FGFR3 in disease 21 3.02e-02 2.73e-01 1.45e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 7.60e-03 -2.73e-01 5.12e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 33 6.72e-03 -2.73e-01 4.60e-02
rRNA processing in the nucleus and cytosol 181 2.65e-10 -2.72e-01 2.52e-08
Diseases associated with N-glycosylation of proteins 19 4.00e-02 -2.72e-01 1.74e-01
Coenzyme A biosynthesis 7 2.13e-01 -2.72e-01 5.10e-01
Autodegradation of the E3 ubiquitin ligase COP1 50 8.97e-04 -2.71e-01 1.05e-02
Signaling by high-kinase activity BRAF mutants 34 6.20e-03 -2.71e-01 4.29e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 51 8.24e-04 -2.71e-01 9.92e-03
Negative regulation of NOTCH4 signaling 53 6.59e-04 -2.70e-01 8.68e-03
Major pathway of rRNA processing in the nucleolus and cytosol 172 9.56e-10 -2.70e-01 7.64e-08
GPCR ligand binding 443 1.88e-22 2.70e-01 9.40e-20
Orexin and neuropeptides FF and QRFP bind to their respective receptors 8 1.87e-01 2.69e-01 4.78e-01
Dectin-1 mediated noncanonical NF-kB signaling 61 2.92e-04 -2.68e-01 5.12e-03
Class A/1 (Rhodopsin-like receptors) 312 3.68e-16 2.68e-01 1.05e-13
TNFR1-mediated ceramide production 6 2.56e-01 -2.68e-01 5.58e-01
Ciprofloxacin ADME 5 3.00e-01 2.68e-01 6.00e-01
SCF-beta-TrCP mediated degradation of Emi1 54 6.62e-04 -2.68e-01 8.68e-03
Sema4D induced cell migration and growth-cone collapse 20 3.82e-02 -2.68e-01 1.68e-01
RAF-independent MAPK1/3 activation 22 2.99e-02 -2.67e-01 1.44e-01
Sensory perception of salty taste 6 2.57e-01 2.67e-01 5.60e-01
Translation initiation complex formation 52 8.55e-04 -2.67e-01 1.02e-02
Eicosanoids 12 1.09e-01 -2.67e-01 3.43e-01
Synthesis of pyrophosphates in the cytosol 8 1.91e-01 2.67e-01 4.82e-01
Fibronectin matrix formation 6 2.58e-01 -2.67e-01 5.60e-01
Peptide ligand-binding receptors 187 3.16e-10 2.67e-01 2.88e-08
Type I hemidesmosome assembly 11 1.26e-01 -2.67e-01 3.75e-01
Fructose metabolism 7 2.22e-01 -2.66e-01 5.24e-01
p130Cas linkage to MAPK signaling for integrins 15 7.43e-02 -2.66e-01 2.68e-01
Defective binding of VWF variant to GPIb:IX:V 7 2.23e-01 2.66e-01 5.24e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 2.23e-01 2.66e-01 5.24e-01
Selenoamino acid metabolism 109 1.74e-06 -2.65e-01 6.00e-05
Potassium Channels 102 3.83e-06 2.65e-01 1.24e-04
Telomere C-strand synthesis initiation 12 1.12e-01 -2.65e-01 3.46e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 1.48e-01 2.65e-01 4.10e-01
Initiation of Nuclear Envelope (NE) Reformation 18 5.24e-02 -2.64e-01 2.12e-01
Intestinal absorption 5 3.07e-01 2.64e-01 6.07e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 49 1.39e-03 -2.64e-01 1.44e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 51 1.12e-03 -2.64e-01 1.22e-02
p53-Independent DNA Damage Response 51 1.12e-03 -2.64e-01 1.22e-02
p53-Independent G1/S DNA damage checkpoint 51 1.12e-03 -2.64e-01 1.22e-02
mRNA Splicing - Minor Pathway 52 1.01e-03 -2.64e-01 1.16e-02
GRB2 events in ERBB2 signaling 16 6.81e-02 2.63e-01 2.52e-01
Ribosomal scanning and start codon recognition 52 1.02e-03 -2.63e-01 1.16e-02
O-glycosylation of TSR domain-containing proteins 38 5.09e-03 2.63e-01 3.69e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 54 8.48e-04 -2.62e-01 1.02e-02
rRNA processing 190 4.55e-10 -2.62e-01 3.96e-08
FRS-mediated FGFR3 signaling 19 4.81e-02 2.62e-01 1.99e-01
PI3K events in ERBB2 signaling 16 6.98e-02 2.62e-01 2.55e-01
Autodegradation of Cdh1 by Cdh1:APC/C 63 3.38e-04 -2.61e-01 5.79e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.04e-01 -2.61e-01 3.33e-01
PI-3K cascade:FGFR2 22 3.44e-02 2.61e-01 1.58e-01
Negative regulation of MAPK pathway 41 3.92e-03 -2.60e-01 3.09e-02
SCF(Skp2)-mediated degradation of p27/p21 59 5.44e-04 -2.60e-01 7.83e-03
DNA Damage Reversal 8 2.03e-01 2.60e-01 4.95e-01
EPHB-mediated forward signaling 41 3.99e-03 -2.60e-01 3.11e-02
SUMO is conjugated to E1 (UBA2:SAE1) 5 3.15e-01 -2.60e-01 6.16e-01
SHC-mediated cascade:FGFR3 17 6.43e-02 2.59e-01 2.42e-01
Signaling by RAF1 mutants 39 5.10e-03 -2.59e-01 3.69e-02
TRAF6 mediated NF-kB activation 24 2.80e-02 -2.59e-01 1.36e-01
RNA Polymerase III Chain Elongation 18 5.70e-02 -2.59e-01 2.22e-01
PI3K Cascade 43 3.35e-03 2.59e-01 2.73e-02
Linoleic acid (LA) metabolism 7 2.36e-01 2.59e-01 5.42e-01
Na+/Cl- dependent neurotransmitter transporters 18 5.80e-02 2.58e-01 2.25e-01
Receptor-type tyrosine-protein phosphatases 16 7.42e-02 2.58e-01 2.68e-01
IRS-related events triggered by IGF1R 50 1.64e-03 2.57e-01 1.63e-02
Regulation of innate immune responses to cytosolic DNA 15 8.43e-02 -2.57e-01 2.90e-01
Ubiquitin-dependent degradation of Cyclin D 51 1.48e-03 -2.57e-01 1.49e-02
XBP1(S) activates chaperone genes 43 3.52e-03 -2.57e-01 2.83e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 73 1.47e-04 -2.57e-01 2.98e-03
SUMOylation of ubiquitinylation proteins 39 5.61e-03 -2.56e-01 3.94e-02
CDH11 homotypic and heterotypic interactions 7 2.41e-01 2.56e-01 5.46e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 8 2.10e-01 -2.56e-01 5.07e-01
Degradation of GLI2 by the proteasome 59 6.73e-04 -2.56e-01 8.74e-03
Impaired BRCA2 binding to RAD51 35 8.93e-03 -2.55e-01 5.76e-02
NIK–>noncanonical NF-kB signaling 58 7.70e-04 -2.55e-01 9.54e-03
AURKA Activation by TPX2 69 2.52e-04 -2.55e-01 4.64e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 53 1.38e-03 -2.54e-01 1.43e-02
Regulation of expression of SLITs and ROBOs 161 2.72e-08 -2.54e-01 1.36e-06
DNA replication initiation 7 2.45e-01 -2.54e-01 5.50e-01
Class B/2 (Secretin family receptors) 93 2.41e-05 2.53e-01 6.34e-04
APC/C:Cdc20 mediated degradation of Securin 67 3.39e-04 -2.53e-01 5.79e-03
Fructose catabolism 5 3.27e-01 -2.53e-01 6.29e-01
IRE1alpha activates chaperones 45 3.47e-03 -2.52e-01 2.81e-02
Scavenging of heme from plasma 12 1.32e-01 -2.51e-01 3.83e-01
IGF1R signaling cascade 51 1.95e-03 2.51e-01 1.82e-02
Cellular response to starvation 145 1.92e-07 -2.50e-01 7.68e-06
Attachment and Entry 9694614 16 8.36e-02 2.50e-01 2.89e-01
Vif-mediated degradation of APOBEC3G 53 1.66e-03 -2.50e-01 1.63e-02
Sema4D in semaphorin signaling 24 3.42e-02 -2.50e-01 1.58e-01
FGFR3b ligand binding and activation 7 2.53e-01 2.50e-01 5.56e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 72 2.56e-04 -2.49e-01 4.65e-03
Defective B3GALTL causes PpS 37 8.79e-03 2.49e-01 5.71e-02
PI-3K cascade:FGFR1 21 4.89e-02 2.48e-01 2.01e-01
Specification of primordial germ cells 11 1.54e-01 2.48e-01 4.23e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.08e-01 -2.48e-01 3.42e-01
PI-3K cascade:FGFR4 19 6.14e-02 2.48e-01 2.35e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.56e-02 -2.48e-01 1.62e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 88 6.04e-05 -2.47e-01 1.39e-03
Diseases of Mismatch Repair (MMR) 5 3.39e-01 -2.47e-01 6.44e-01
Activation of NF-kappaB in B cells 65 5.69e-04 -2.47e-01 8.06e-03
Presynaptic phase of homologous DNA pairing and strand exchange 40 6.96e-03 -2.47e-01 4.73e-02
Regulation of PTEN mRNA translation 24 3.65e-02 2.47e-01 1.64e-01
The citric acid (TCA) cycle and respiratory electron transport 159 8.58e-08 -2.46e-01 3.65e-06
FGFR1 ligand binding and activation 17 7.92e-02 2.46e-01 2.78e-01
WNT ligand biogenesis and trafficking 25 3.34e-02 2.46e-01 1.56e-01
Defective CFTR causes cystic fibrosis 60 1.02e-03 -2.45e-01 1.16e-02
Trafficking and processing of endosomal TLR 11 1.60e-01 2.45e-01 4.32e-01
Downstream signaling events of B Cell Receptor (BCR) 79 1.69e-04 -2.45e-01 3.38e-03
Anchoring of the basal body to the plasma membrane 93 4.55e-05 -2.45e-01 1.11e-03
GLI3 is processed to GLI3R by the proteasome 59 1.16e-03 -2.45e-01 1.24e-02
Sensory perception of taste 45 4.54e-03 2.45e-01 3.40e-02
Formyl peptide receptors bind formyl peptides and many other ligands 8 2.31e-01 2.44e-01 5.34e-01
Formation of definitive endoderm 16 9.11e-02 2.44e-01 3.06e-01
Aryl hydrocarbon receptor signalling 7 2.64e-01 -2.44e-01 5.65e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 2.65e-01 -2.43e-01 5.66e-01
Degradation of GLI1 by the proteasome 59 1.24e-03 -2.43e-01 1.30e-02
Regulation of CDH11 Expression and Function 29 2.37e-02 2.43e-01 1.22e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 7 2.67e-01 2.43e-01 5.67e-01
Hh mutants are degraded by ERAD 55 1.92e-03 -2.42e-01 1.81e-02
MASTL Facilitates Mitotic Progression 10 1.86e-01 -2.41e-01 4.78e-01
Regulation of FZD by ubiquitination 21 5.62e-02 2.41e-01 2.20e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.52e-02 -2.41e-01 8.69e-02
Phosphorylation of the APC/C 20 6.28e-02 -2.40e-01 2.39e-01
HDR through Homologous Recombination (HRR) 66 7.63e-04 -2.40e-01 9.54e-03
Loss of Nlp from mitotic centrosomes 66 7.73e-04 -2.39e-01 9.54e-03
Loss of proteins required for interphase microtubule organization from the centrosome 66 7.73e-04 -2.39e-01 9.54e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 73 4.29e-04 -2.38e-01 6.67e-03
Unfolded Protein Response (UPR) 86 1.37e-04 -2.38e-01 2.86e-03
VLDL clearance 6 3.13e-01 2.38e-01 6.15e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 54 2.53e-03 -2.38e-01 2.23e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 3.58e-01 -2.37e-01 6.66e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 1.11e-01 2.37e-01 3.46e-01
IRS-mediated signalling 47 4.91e-03 2.37e-01 3.58e-02
Class I peroxisomal membrane protein import 19 7.35e-02 -2.37e-01 2.67e-01
Zinc efflux and compartmentalization by the SLC30 family 5 3.59e-01 -2.37e-01 6.66e-01
Processing of Capped Intron-Containing Pre-mRNA 265 3.07e-11 -2.37e-01 4.10e-09
Sensory perception of sweet, bitter, and umami (glutamate) taste 40 9.61e-03 2.37e-01 6.10e-02
The activation of arylsulfatases 8 2.47e-01 -2.36e-01 5.50e-01
Ketone body metabolism 9 2.19e-01 2.36e-01 5.18e-01
CDK-mediated phosphorylation and removal of Cdc6 72 5.20e-04 -2.36e-01 7.65e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 8.80e-03 -2.36e-01 5.71e-02
Diseases of DNA Double-Strand Break Repair 41 8.80e-03 -2.36e-01 5.71e-02
Cyclin E associated events during G1/S transition 82 2.15e-04 -2.36e-01 4.13e-03
Peptide hormone biosynthesis 11 1.75e-01 2.36e-01 4.60e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 52 3.25e-03 2.36e-01 2.70e-02
Downstream signaling of activated FGFR1 31 2.31e-02 2.36e-01 1.19e-01
Defective GALNT3 causes HFTC 18 8.36e-02 -2.36e-01 2.89e-01
Phosphate bond hydrolysis by NUDT proteins 7 2.81e-01 -2.36e-01 5.82e-01
Josephin domain DUBs 10 1.97e-01 -2.35e-01 4.90e-01
SHC1 events in ERBB4 signaling 14 1.27e-01 2.35e-01 3.77e-01
MET interacts with TNS proteins 5 3.62e-01 -2.35e-01 6.67e-01
Regulation of APC/C activators between G1/S and early anaphase 80 2.81e-04 -2.35e-01 5.02e-03
Interleukin-20 family signaling 24 4.64e-02 2.35e-01 1.93e-01
Regulation of Apoptosis 52 3.45e-03 -2.34e-01 2.80e-02
Regulation of RUNX3 expression and activity 54 2.88e-03 -2.34e-01 2.45e-02
SUMOylation of RNA binding proteins 47 5.49e-03 -2.34e-01 3.92e-02
Interleukin-9 signaling 7 2.84e-01 2.34e-01 5.84e-01
Inflammasomes 21 6.36e-02 -2.34e-01 2.42e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 76 4.30e-04 -2.34e-01 6.67e-03
Downstream signaling of activated FGFR3 24 4.77e-02 2.33e-01 1.98e-01
Acetylcholine Neurotransmitter Release Cycle 17 9.57e-02 2.33e-01 3.16e-01
tRNA processing in the nucleus 58 2.14e-03 -2.33e-01 1.96e-02
Homologous DNA Pairing and Strand Exchange 43 8.30e-03 -2.33e-01 5.53e-02
Surfactant metabolism 26 4.01e-02 2.33e-01 1.74e-01
Platelet Adhesion to exposed collagen 16 1.07e-01 2.32e-01 3.40e-01
SARS-CoV-1-host interactions 91 1.28e-04 -2.32e-01 2.70e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 3.69e-02 -2.32e-01 1.65e-01
Biosynthesis of EPA-derived SPMs 6 3.25e-01 2.32e-01 6.27e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.65e-01 -2.32e-01 4.41e-01
Role of ABL in ROBO-SLIT signaling 8 2.58e-01 2.31e-01 5.60e-01
Cyclin A:Cdk2-associated events at S phase entry 84 2.52e-04 -2.31e-01 4.64e-03
TFAP2 (AP-2) family regulates transcription of cell cycle factors 5 3.72e-01 2.31e-01 6.77e-01
Nef Mediated CD8 Down-regulation 7 2.92e-01 2.30e-01 5.92e-01
The NLRP3 inflammasome 16 1.11e-01 -2.30e-01 3.46e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 75 5.79e-04 -2.30e-01 8.09e-03
Nicotinamide salvaging 19 8.39e-02 2.29e-01 2.89e-01
Biosynthesis of maresins 8 2.62e-01 2.29e-01 5.65e-01
HDR through Single Strand Annealing (SSA) 37 1.61e-02 -2.29e-01 8.97e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 1.25e-01 -2.29e-01 3.74e-01
RNA polymerase II transcribes snRNA genes 74 6.94e-04 -2.28e-01 8.95e-03
Early Phase of HIV Life Cycle 14 1.41e-01 -2.27e-01 3.97e-01
Centrosome maturation 78 5.16e-04 -2.27e-01 7.65e-03
Recruitment of mitotic centrosome proteins and complexes 78 5.16e-04 -2.27e-01 7.65e-03
Fatty acids 14 1.41e-01 -2.27e-01 3.97e-01
Sensory Perception 526 4.65e-19 2.27e-01 1.86e-16
Lewis blood group biosynthesis 18 9.52e-02 2.27e-01 3.16e-01
Impaired BRCA2 binding to PALB2 24 5.43e-02 -2.27e-01 2.16e-01
VEGF binds to VEGFR leading to receptor dimerization 7 2.99e-01 2.27e-01 5.99e-01
VEGF ligand-receptor interactions 7 2.99e-01 2.27e-01 5.99e-01
Regulation of PLK1 Activity at G2/M Transition 84 3.34e-04 -2.26e-01 5.79e-03
Stabilization of p53 55 3.70e-03 -2.26e-01 2.96e-02
Intrinsic Pathway of Fibrin Clot Formation 21 7.29e-02 2.26e-01 2.65e-01
Trafficking of GluR2-containing AMPA receptors 15 1.30e-01 2.26e-01 3.81e-01
RHO GTPases Activate ROCKs 19 8.93e-02 -2.25e-01 3.02e-01
mRNA Splicing 200 4.14e-08 -2.25e-01 1.88e-06
FRS-mediated FGFR2 signaling 24 5.69e-02 2.25e-01 2.22e-01
Peroxisomal lipid metabolism 28 3.99e-02 -2.24e-01 1.74e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 2.46e-01 -2.23e-01 5.50e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 8 2.76e-01 2.22e-01 5.77e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 4.18e-02 -2.22e-01 1.79e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 5.45e-02 -2.22e-01 2.16e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 5.45e-02 -2.22e-01 2.16e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 5.45e-02 -2.22e-01 2.16e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 5.45e-02 -2.22e-01 2.16e-01
Degradation of DVL 56 4.02e-03 -2.22e-01 3.13e-02
Heparan sulfate/heparin (HS-GAG) metabolism 52 5.60e-03 2.22e-01 3.94e-02
CLEC7A/inflammasome pathway 6 3.46e-01 -2.22e-01 6.53e-01
mRNA Splicing - Major Pathway 190 1.31e-07 -2.22e-01 5.36e-06
Metabolism of RNA 689 4.75e-23 -2.21e-01 3.16e-20
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 1.53e-01 2.20e-01 4.21e-01
Germ layer formation at gastrulation 16 1.27e-01 2.20e-01 3.77e-01
rRNA modification in the nucleus and cytosol 57 4.13e-03 -2.20e-01 3.18e-02
Mitotic Prophase 104 1.09e-04 -2.20e-01 2.34e-03
APC/C-mediated degradation of cell cycle proteins 87 4.03e-04 -2.19e-01 6.44e-03
Regulation of mitotic cell cycle 87 4.03e-04 -2.19e-01 6.44e-03
RNA Polymerase III Transcription Termination 23 6.88e-02 -2.19e-01 2.54e-01
SHC-mediated cascade:FGFR2 22 7.52e-02 2.19e-01 2.70e-01
Diseases of DNA repair 51 6.85e-03 -2.19e-01 4.68e-02
Butyrophilin (BTN) family interactions 12 1.90e-01 2.18e-01 4.81e-01
Cristae formation 26 5.41e-02 -2.18e-01 2.16e-01
Apoptotic factor-mediated response 18 1.09e-01 -2.18e-01 3.43e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 5.47e-02 -2.18e-01 2.17e-01
Receptor Mediated Mitophagy 10 2.35e-01 -2.17e-01 5.41e-01
Gap junction degradation 12 1.94e-01 -2.16e-01 4.88e-01
Rap1 signalling 16 1.35e-01 -2.16e-01 3.86e-01
Glycolysis 72 1.55e-03 -2.16e-01 1.56e-02
Separation of Sister Chromatids 182 5.22e-07 -2.16e-01 1.93e-05
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 3.92e-04 -2.15e-01 6.44e-03
Amplification of signal from the kinetochores 91 3.92e-04 -2.15e-01 6.44e-03
Regulation of PTEN localization 8 2.92e-01 -2.15e-01 5.93e-01
Mitotic Prometaphase 192 2.91e-07 -2.15e-01 1.12e-05
Regulation of RAS by GAPs 66 2.58e-03 -2.14e-01 2.26e-02
Fanconi Anemia Pathway 34 3.05e-02 -2.14e-01 1.45e-01
Interleukin-12 signaling 41 1.78e-02 -2.14e-01 9.80e-02
Synaptic adhesion-like molecules 19 1.07e-01 2.14e-01 3.38e-01
PI5P Regulates TP53 Acetylation 8 2.97e-01 -2.13e-01 5.97e-01
Mitotic Metaphase and Anaphase 226 3.37e-08 -2.13e-01 1.60e-06
Mitotic Anaphase 225 3.62e-08 -2.13e-01 1.68e-06
Host Interactions of HIV factors 126 3.63e-05 -2.13e-01 8.99e-04
Acyl chain remodeling of CL 5 4.11e-01 -2.12e-01 7.09e-01
G1/S Transition 127 3.64e-05 -2.12e-01 8.99e-04
Mitotic Spindle Checkpoint 108 1.43e-04 -2.12e-01 2.93e-03
M Phase 366 3.44e-12 -2.12e-01 4.91e-10
FRS-mediated FGFR1 signaling 23 7.88e-02 2.12e-01 2.78e-01
Metabolism of folate and pterines 17 1.32e-01 -2.11e-01 3.82e-01
Norepinephrine Neurotransmitter Release Cycle 17 1.33e-01 2.11e-01 3.84e-01
Transcriptional regulation by small RNAs 70 2.34e-03 -2.10e-01 2.08e-02
G1/S DNA Damage Checkpoints 66 3.20e-03 -2.10e-01 2.68e-02
Integrin signaling 27 5.99e-02 -2.09e-01 2.31e-01
p53-Dependent G1 DNA Damage Response 64 3.88e-03 -2.09e-01 3.07e-02
p53-Dependent G1/S DNA damage checkpoint 64 3.88e-03 -2.09e-01 3.07e-02
Displacement of DNA glycosylase by APEX1 9 2.79e-01 -2.09e-01 5.79e-01
FRS-mediated FGFR4 signaling 21 9.91e-02 2.08e-01 3.22e-01
Regulation of Expression and Function of Type II Classical Cadherins 32 4.20e-02 2.08e-01 1.79e-01
Regulation of Homotypic Cell-Cell Adhesion 32 4.20e-02 2.08e-01 1.79e-01
Downstream signaling of activated FGFR2 29 5.31e-02 2.07e-01 2.15e-01
Interleukin-12 family signaling 51 1.06e-02 -2.07e-01 6.52e-02
EGFR interacts with phospholipase C-gamma 8 3.11e-01 2.07e-01 6.13e-01
Resolution of Sister Chromatid Cohesion 118 1.10e-04 -2.06e-01 2.34e-03
Frs2-mediated activation 12 2.18e-01 -2.05e-01 5.18e-01
Glucose metabolism 92 6.62e-04 -2.05e-01 8.68e-03
SHC-mediated cascade:FGFR1 21 1.04e-01 2.05e-01 3.33e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 2.87e-01 -2.05e-01 5.88e-01
Defective GALNT12 causes CRCS1 18 1.34e-01 -2.04e-01 3.86e-01
Hormone ligand-binding receptors 13 2.03e-01 2.04e-01 4.95e-01
AKT phosphorylates targets in the cytosol 14 1.87e-01 -2.04e-01 4.78e-01
ISG15 antiviral mechanism 74 2.47e-03 -2.04e-01 2.18e-02
Methionine salvage pathway 6 3.88e-01 -2.03e-01 6.89e-01
RHO GTPases Activate Formins 134 4.99e-05 -2.03e-01 1.18e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 76 2.33e-03 -2.02e-01 2.08e-02
mRNA 3’-end processing 53 1.10e-02 -2.02e-01 6.73e-02
CASP8 activity is inhibited 11 2.47e-01 -2.02e-01 5.50e-01
Dimerization of procaspase-8 11 2.47e-01 -2.02e-01 5.50e-01
Regulation by c-FLIP 11 2.47e-01 -2.02e-01 5.50e-01
Synthesis of PG 8 3.24e-01 -2.01e-01 6.26e-01
GABA receptor activation 57 8.54e-03 2.01e-01 5.65e-02
Defective C1GALT1C1 causes TNPS 18 1.39e-01 -2.01e-01 3.96e-01
UCH proteinases 93 7.93e-04 -2.01e-01 9.72e-03
mRNA decay by 5’ to 3’ exoribonuclease 15 1.78e-01 -2.01e-01 4.64e-01
NR1H2 and NR1H3-mediated signaling 53 1.14e-02 2.01e-01 6.94e-02
Regulation of CDH11 function 10 2.72e-01 2.01e-01 5.75e-01
Hh mutants abrogate ligand secretion 58 8.26e-03 -2.00e-01 5.52e-02
SARS-CoV-1 activates/modulates innate immune responses 39 3.03e-02 -2.00e-01 1.45e-01
Mitotic G1 phase and G1/S transition 145 3.12e-05 -2.00e-01 7.90e-04
RHO GTPases Activate WASPs and WAVEs 34 4.34e-02 -2.00e-01 1.84e-01
SHC-mediated cascade:FGFR4 19 1.32e-01 2.00e-01 3.82e-01
Signaling by ROBO receptors 206 7.70e-07 -2.00e-01 2.70e-05
FGFR2 alternative splicing 26 7.83e-02 -1.99e-01 2.77e-01
Inhibition of Signaling by Overexpressed EGFR 7 3.61e-01 1.99e-01 6.67e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 7 3.61e-01 1.99e-01 6.67e-01
Switching of origins to a post-replicative state 91 1.01e-03 -1.99e-01 1.16e-02
Degradation of AXIN 54 1.13e-02 -1.99e-01 6.88e-02
Signaling by activated point mutants of FGFR1 11 2.53e-01 1.99e-01 5.56e-01
Nucleotide biosynthesis 12 2.34e-01 -1.98e-01 5.39e-01
Propionyl-CoA catabolism 5 4.43e-01 -1.98e-01 7.36e-01
Uptake of dietary cobalamins into enterocytes 9 3.03e-01 1.98e-01 6.03e-01
Insulin receptor signalling cascade 53 1.29e-02 1.97e-01 7.50e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 9 3.06e-01 1.97e-01 6.07e-01
Wax and plasmalogen biosynthesis 5 4.46e-01 -1.97e-01 7.38e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.19e-01 -1.97e-01 3.59e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.19e-01 -1.97e-01 3.59e-01
Orc1 removal from chromatin 70 4.44e-03 -1.97e-01 3.34e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 53 1.33e-02 -1.97e-01 7.69e-02
Formation of apoptosome 10 2.82e-01 -1.97e-01 5.82e-01
Regulation of the apoptosome activity 10 2.82e-01 -1.97e-01 5.82e-01
Cytochrome c-mediated apoptotic response 12 2.39e-01 -1.96e-01 5.45e-01
Cell-extracellular matrix interactions 16 1.74e-01 -1.96e-01 4.58e-01
Cytoprotection by HMOX1 58 9.80e-03 -1.96e-01 6.20e-02
GDP-fucose biosynthesis 6 4.06e-01 1.96e-01 7.05e-01
WNT mediated activation of DVL 8 3.37e-01 -1.96e-01 6.43e-01
Mitotic G2-G2/M phases 193 2.82e-06 -1.95e-01 9.40e-05
RAF activation 32 5.57e-02 -1.95e-01 2.19e-01
Cell Cycle Checkpoints 264 4.56e-08 -1.95e-01 2.03e-06
G2/M Checkpoints 144 5.25e-05 -1.95e-01 1.22e-03
NOTCH4 Intracellular Domain Regulates Transcription 19 1.42e-01 1.95e-01 3.99e-01
Mineralocorticoid biosynthesis 5 4.51e-01 1.95e-01 7.40e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 4.09e-01 -1.94e-01 7.07e-01
G2/M Transition 191 3.72e-06 -1.94e-01 1.22e-04
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 5 4.52e-01 -1.94e-01 7.41e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 1.34e-01 -1.94e-01 3.86e-01
Erythrocytes take up carbon dioxide and release oxygen 12 2.46e-01 -1.94e-01 5.50e-01
O2/CO2 exchange in erythrocytes 12 2.46e-01 -1.94e-01 5.50e-01
ABC transporter disorders 76 3.65e-03 -1.93e-01 2.93e-02
SHC-related events triggered by IGF1R 9 3.17e-01 1.93e-01 6.20e-01
ERBB2 Regulates Cell Motility 15 1.97e-01 1.92e-01 4.90e-01
Nicotinate metabolism 31 6.41e-02 1.92e-01 2.42e-01
Downstream signaling of activated FGFR4 26 9.01e-02 1.92e-01 3.03e-01
Activated NTRK2 signals through FRS2 and FRS3 11 2.71e-01 1.92e-01 5.74e-01
Signaling by BRAF and RAF1 fusions 63 8.62e-03 -1.91e-01 5.65e-02
Ribavirin ADME 11 2.72e-01 -1.91e-01 5.75e-01
Opsins 7 3.82e-01 1.91e-01 6.85e-01
Blood group systems biosynthesis 21 1.30e-01 1.91e-01 3.81e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 1.30e-01 -1.91e-01 3.81e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 1.06e-01 -1.91e-01 3.38e-01
RNA Polymerase II Transcription Termination 62 9.46e-03 -1.91e-01 6.04e-02
MAP kinase activation 58 1.24e-02 -1.90e-01 7.27e-02
Negative feedback regulation of MAPK pathway 6 4.23e-01 -1.89e-01 7.18e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 3.01e-01 -1.89e-01 6.01e-01
Mitochondrial biogenesis 84 2.82e-03 -1.88e-01 2.41e-02
CLEC7A (Dectin-1) signaling 97 1.34e-03 -1.88e-01 1.39e-02
DNA Replication Pre-Initiation 120 3.69e-04 -1.88e-01 6.25e-03
G alpha (i) signalling events 304 1.69e-08 1.88e-01 9.16e-07
Transcriptional Regulation by MECP2 60 1.18e-02 1.88e-01 7.04e-02
Post-translational protein phosphorylation 100 1.18e-03 1.88e-01 1.26e-02
Transcriptional activation of mitochondrial biogenesis 50 2.17e-02 -1.88e-01 1.14e-01
Axonal growth inhibition (RHOA activation) 8 3.58e-01 -1.88e-01 6.66e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 43 3.34e-02 1.87e-01 1.56e-01
Assembly of the pre-replicative complex 105 9.04e-04 -1.87e-01 1.05e-02
Activation of RAC1 12 2.61e-01 1.87e-01 5.65e-01
Glycoprotein hormones 9 3.33e-01 1.86e-01 6.37e-01
Cell Cycle, Mitotic 507 7.68e-13 -1.86e-01 1.40e-10
FCERI mediated NF-kB activation 78 4.57e-03 -1.86e-01 3.41e-02
Mitochondrial protein import 57 1.54e-02 -1.86e-01 8.73e-02
Downregulation of ERBB4 signaling 9 3.35e-01 -1.86e-01 6.40e-01
Oncogenic MAPK signaling 78 4.63e-03 -1.85e-01 3.43e-02
G1/S-Specific Transcription 28 8.98e-02 -1.85e-01 3.03e-01
Signal transduction by L1 20 1.52e-01 -1.85e-01 4.19e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.88e-01 -1.85e-01 5.89e-01
tRNA processing 105 1.12e-03 -1.84e-01 1.22e-02
Reversible hydration of carbon dioxide 11 2.91e-01 1.84e-01 5.91e-01
Arachidonate production from DAG 5 4.77e-01 -1.83e-01 7.61e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.15e-02 -1.83e-01 6.96e-02
Methylation 14 2.37e-01 -1.83e-01 5.43e-01
S Phase 159 7.19e-05 -1.82e-01 1.63e-03
Recruitment of NuMA to mitotic centrosomes 90 2.81e-03 -1.82e-01 2.41e-02
Heme biosynthesis 13 2.56e-01 -1.82e-01 5.59e-01
Signaling by the B Cell Receptor (BCR) 106 1.27e-03 -1.81e-01 1.33e-02
Interleukin-1 signaling 110 1.04e-03 -1.81e-01 1.17e-02
Removal of the Flap Intermediate from the C-strand 17 1.98e-01 -1.81e-01 4.90e-01
Chylomicron assembly 10 3.24e-01 1.80e-01 6.26e-01
Keratinization 198 1.24e-05 1.80e-01 3.61e-04
Signaling by ERBB2 TMD/JMD mutants 22 1.44e-01 1.80e-01 4.02e-01
Mitochondrial protein degradation 84 4.34e-03 -1.80e-01 3.31e-02
Activation of BAD and translocation to mitochondria 15 2.27e-01 -1.80e-01 5.28e-01
Cholesterol biosynthesis 25 1.20e-01 -1.79e-01 3.63e-01
ER-Phagosome pathway 86 4.05e-03 -1.79e-01 3.14e-02
Deadenylation-dependent mRNA decay 53 2.42e-02 -1.79e-01 1.24e-01
Adherens junctions interactions 58 1.87e-02 1.78e-01 1.03e-01
RUNX3 regulates CDKN1A transcription 7 4.14e-01 -1.78e-01 7.11e-01
ABC-family proteins mediated transport 99 2.16e-03 -1.78e-01 1.96e-02
Prolonged ERK activation events 14 2.49e-01 -1.78e-01 5.53e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 3.84e-01 -1.78e-01 6.87e-01
Reversal of alkylation damage by DNA dioxygenases 7 4.16e-01 1.78e-01 7.13e-01
Nuclear events mediated by NFE2L2 92 3.25e-03 -1.78e-01 2.70e-02
Triglyceride catabolism 23 1.41e-01 1.77e-01 3.97e-01
RIPK1-mediated regulated necrosis 29 9.82e-02 -1.77e-01 3.20e-01
Regulation of necroptotic cell death 29 9.82e-02 -1.77e-01 3.20e-01
EML4 and NUDC in mitotic spindle formation 112 1.19e-03 -1.77e-01 1.26e-02
Signaling by ERBB2 KD Mutants 25 1.27e-01 1.76e-01 3.77e-01
HIV elongation arrest and recovery 33 8.01e-02 -1.76e-01 2.81e-01
Pausing and recovery of HIV elongation 33 8.01e-02 -1.76e-01 2.81e-01
Cell Cycle 631 4.81e-14 -1.76e-01 1.07e-11
Anchoring fibril formation 13 2.73e-01 1.76e-01 5.75e-01
Deposition of new CENPA-containing nucleosomes at the centromere 46 3.99e-02 -1.75e-01 1.74e-01
Nucleosome assembly 46 3.99e-02 -1.75e-01 1.74e-01
Zygotic genome activation (ZGA) 13 2.74e-01 1.75e-01 5.76e-01
Signalling to RAS 20 1.75e-01 -1.75e-01 4.60e-01
TNF signaling 54 2.66e-02 -1.74e-01 1.30e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 2.43e-01 -1.74e-01 5.49e-01
Sensory processing of sound by outer hair cells of the cochlea 49 3.49e-02 -1.74e-01 1.60e-01
Acyl chain remodeling of DAG and TAG 5 5.00e-01 -1.74e-01 7.65e-01
SARS-CoV-2-host interactions 183 4.90e-05 -1.74e-01 1.18e-03
Activation of SMO 18 2.02e-01 1.74e-01 4.94e-01
Signaling by GPCR 672 1.49e-14 1.74e-01 3.72e-12
Hedgehog ligand biogenesis 64 1.62e-02 -1.74e-01 8.98e-02
E3 ubiquitin ligases ubiquitinate target proteins 54 2.73e-02 -1.74e-01 1.34e-01
CHL1 interactions 9 3.69e-01 1.73e-01 6.74e-01
FGFR2 ligand binding and activation 19 1.92e-01 1.73e-01 4.84e-01
Fertilization 26 1.28e-01 -1.73e-01 3.77e-01
Downstream TCR signaling 89 4.91e-03 -1.73e-01 3.58e-02
Interleukin-35 Signalling 12 3.01e-01 -1.72e-01 6.01e-01
Gap junction assembly 35 7.78e-02 1.72e-01 2.76e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 7 4.30e-01 1.72e-01 7.25e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 7 4.30e-01 1.72e-01 7.25e-01
Translocation of ZAP-70 to Immunological synapse 13 2.84e-01 1.72e-01 5.84e-01
Regulation of TNFR1 signaling 46 4.41e-02 -1.72e-01 1.86e-01
Incretin synthesis, secretion, and inactivation 23 1.55e-01 1.71e-01 4.23e-01
Activated NTRK2 signals through RAS 9 3.74e-01 1.71e-01 6.79e-01
Tyrosine catabolism 5 5.08e-01 -1.71e-01 7.70e-01
GABA synthesis, release, reuptake and degradation 19 2.00e-01 1.70e-01 4.92e-01
Nuclear Envelope (NE) Reassembly 73 1.23e-02 -1.69e-01 7.27e-02
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 5 5.12e-01 1.69e-01 7.71e-01
Lipid particle organization 6 4.73e-01 1.69e-01 7.61e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 4.39e-01 -1.69e-01 7.32e-01
DNA Double-Strand Break Repair 144 4.70e-04 -1.69e-01 7.23e-03
Cell-cell junction organization 88 6.24e-03 1.69e-01 4.30e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 117 1.65e-03 1.68e-01 1.63e-02
Signalling to ERKs 34 8.94e-02 -1.68e-01 3.02e-01
Integration of provirus 9 3.82e-01 -1.68e-01 6.85e-01
APC-Cdc20 mediated degradation of Nek2A 26 1.38e-01 -1.68e-01 3.95e-01
G2/M DNA damage checkpoint 72 1.38e-02 -1.68e-01 7.95e-02
Pausing and recovery of Tat-mediated HIV elongation 31 1.06e-01 -1.68e-01 3.38e-01
Tat-mediated HIV elongation arrest and recovery 31 1.06e-01 -1.68e-01 3.38e-01
FasL/ CD95L signaling 5 5.18e-01 -1.67e-01 7.76e-01
HCMV Late Events 81 9.60e-03 -1.66e-01 6.10e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 1.98e-01 -1.66e-01 4.90e-01
DNA Damage Recognition in GG-NER 36 8.46e-02 -1.66e-01 2.90e-01
TRAF3-dependent IRF activation pathway 15 2.65e-01 -1.66e-01 5.66e-01
Protein localization 152 4.19e-04 -1.66e-01 6.64e-03
LTC4-CYSLTR mediated IL4 production 6 4.82e-01 -1.66e-01 7.61e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 1.52e-01 -1.66e-01 4.19e-01
Synthesis of 12-eicosatetraenoic acid derivatives 7 4.49e-01 -1.65e-01 7.38e-01
Assembly of active LPL and LIPC lipase complexes 18 2.25e-01 -1.65e-01 5.25e-01
RHO GTPases Activate NADPH Oxidases 21 1.90e-01 -1.65e-01 4.81e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 2.26e-01 -1.65e-01 5.27e-01
Cargo concentration in the ER 31 1.13e-01 -1.65e-01 3.46e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 1.40e-01 -1.64e-01 3.96e-01
Metabolism of cofactors 19 2.16e-01 -1.64e-01 5.15e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 1.65e-01 1.64e-01 4.41e-01
Synthesis of DNA 119 2.03e-03 -1.64e-01 1.88e-02
CYP2E1 reactions 9 3.98e-01 1.63e-01 6.99e-01
ABC transporters in lipid homeostasis 17 2.46e-01 -1.63e-01 5.50e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 5 5.29e-01 1.62e-01 7.85e-01
Nuclear signaling by ERBB4 32 1.12e-01 1.62e-01 3.46e-01
Regulation of HSF1-mediated heat shock response 79 1.27e-02 -1.62e-01 7.45e-02
RAS processing 22 1.88e-01 -1.62e-01 4.78e-01
Attachment of GPI anchor to uPAR 7 4.58e-01 -1.62e-01 7.44e-01
Tight junction interactions 28 1.39e-01 1.62e-01 3.96e-01
Assembly of collagen fibrils and other multimeric structures 59 3.21e-02 1.61e-01 1.51e-01
Degradation of beta-catenin by the destruction complex 83 1.15e-02 -1.61e-01 6.95e-02
Antiviral mechanism by IFN-stimulated genes 144 8.95e-04 -1.60e-01 1.05e-02
Acyl chain remodelling of PI 17 2.53e-01 -1.60e-01 5.56e-01
FGFR1c ligand binding and activation 13 3.17e-01 1.60e-01 6.20e-01
Homology Directed Repair 114 3.19e-03 -1.60e-01 2.68e-02
Defective Intrinsic Pathway for Apoptosis 25 1.66e-01 -1.60e-01 4.43e-01
DSCAM interactions 11 3.59e-01 -1.60e-01 6.66e-01
Protein ubiquitination 72 1.92e-02 -1.60e-01 1.05e-01
Association of TriC/CCT with target proteins during biosynthesis 38 8.88e-02 -1.60e-01 3.02e-01
Neuronal System 389 6.63e-08 1.59e-01 2.88e-06
SOS-mediated signalling 7 4.65e-01 1.59e-01 7.52e-01
DNA Replication 148 8.22e-04 -1.59e-01 9.92e-03
Activation of ATR in response to replication stress 37 9.52e-02 -1.59e-01 3.16e-01
SHC1 events in ERBB2 signaling 22 1.98e-01 1.58e-01 4.90e-01
Unblocking of NMDA receptors, glutamate binding and activation 19 2.33e-01 1.58e-01 5.36e-01
Somitogenesis 54 4.45e-02 -1.58e-01 1.87e-01
GPCR downstream signalling 602 3.56e-11 1.58e-01 4.45e-09
Miscellaneous transport and binding events 24 1.81e-01 1.58e-01 4.67e-01
Removal of the Flap Intermediate 13 3.26e-01 -1.57e-01 6.28e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 1.13e-01 1.57e-01 3.46e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.04e-01 -1.57e-01 3.33e-01
NCAM1 interactions 41 8.29e-02 1.57e-01 2.88e-01
Interferon alpha/beta signaling 68 2.60e-02 1.56e-01 1.28e-01
Defects in vitamin and cofactor metabolism 21 2.16e-01 -1.56e-01 5.15e-01
Peroxisomal protein import 62 3.41e-02 -1.56e-01 1.58e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 1.40e-01 -1.55e-01 3.97e-01
The canonical retinoid cycle in rods (twilight vision) 23 1.97e-01 1.55e-01 4.90e-01
MyD88 cascade initiated on plasma membrane 91 1.05e-02 -1.55e-01 6.50e-02
Toll Like Receptor 10 (TLR10) Cascade 91 1.05e-02 -1.55e-01 6.50e-02
Toll Like Receptor 5 (TLR5) Cascade 91 1.05e-02 -1.55e-01 6.50e-02
WNT5A-dependent internalization of FZD4 15 2.98e-01 1.55e-01 5.99e-01
MET activates RAS signaling 11 3.73e-01 -1.55e-01 6.79e-01
Activation of PUMA and translocation to mitochondria 9 4.21e-01 1.55e-01 7.16e-01
Biosynthesis of DHA-derived SPMs 17 2.71e-01 1.54e-01 5.74e-01
Cytosolic sensors of pathogen-associated DNA 63 3.42e-02 -1.54e-01 1.58e-01
Activation of RAS in B cells 5 5.51e-01 -1.54e-01 8.00e-01
Antigen processing-Cross presentation 97 8.88e-03 -1.54e-01 5.74e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 108 5.79e-03 -1.54e-01 4.05e-02
Metallothioneins bind metals 11 3.78e-01 1.54e-01 6.83e-01
MECP2 regulates neuronal receptors and channels 17 2.74e-01 1.53e-01 5.76e-01
C-type lectin receptors (CLRs) 138 1.91e-03 -1.53e-01 1.80e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 95 1.00e-02 -1.53e-01 6.31e-02
Eicosanoid ligand-binding receptors 14 3.23e-01 1.53e-01 6.26e-01
Degradation of the extracellular matrix 134 2.29e-03 1.53e-01 2.05e-02
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 5 5.55e-01 1.52e-01 8.02e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 3.60e-01 1.52e-01 6.67e-01
Defective EXT2 causes exostoses 2 12 3.60e-01 1.52e-01 6.67e-01
SUMOylation of intracellular receptors 29 1.55e-01 1.52e-01 4.24e-01
Transport of organic anions 10 4.05e-01 1.52e-01 7.04e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 2.64e-01 -1.52e-01 5.65e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 31 1.43e-01 -1.52e-01 4.02e-01
Metabolism of fat-soluble vitamins 46 7.48e-02 1.52e-01 2.69e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 5.58e-01 -1.51e-01 8.04e-01
Cellular response to heat stress 96 1.06e-02 -1.51e-01 6.52e-02
Purine salvage 12 3.66e-01 -1.51e-01 6.71e-01
Cytosolic tRNA aminoacylation 22 2.22e-01 -1.50e-01 5.24e-01
RHO GTPase Effectors 272 1.98e-05 -1.50e-01 5.35e-04
Suppression of phagosomal maturation 13 3.48e-01 -1.50e-01 6.54e-01
Gastrulation 125 3.76e-03 1.50e-01 3.00e-02
Processing and activation of SUMO 10 4.11e-01 -1.50e-01 7.09e-01
Signaling by BMP 30 1.55e-01 1.50e-01 4.24e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 3.69e-01 1.50e-01 6.74e-01
alpha-linolenic acid (ALA) metabolism 12 3.69e-01 1.50e-01 6.74e-01
CRMPs in Sema3A signaling 15 3.16e-01 1.50e-01 6.18e-01
Retinoid metabolism and transport 42 9.36e-02 1.50e-01 3.12e-01
Synthesis of 5-eicosatetraenoic acids 9 4.38e-01 -1.49e-01 7.32e-01
TCR signaling 108 7.37e-03 -1.49e-01 4.99e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 3.34e-01 1.49e-01 6.38e-01
IRS activation 5 5.64e-01 1.49e-01 8.08e-01
activated TAK1 mediates p38 MAPK activation 20 2.50e-01 -1.49e-01 5.54e-01
Signaling by ERBB2 in Cancer 26 1.91e-01 1.48e-01 4.81e-01
Translesion synthesis by POLK 17 2.91e-01 -1.48e-01 5.91e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 3.76e-01 -1.48e-01 6.82e-01
Regulation of NPAS4 gene expression 13 3.57e-01 1.48e-01 6.66e-01
TYSND1 cleaves peroxisomal proteins 7 4.99e-01 -1.47e-01 7.65e-01
Myogenesis 29 1.70e-01 1.47e-01 4.48e-01
HIV Life Cycle 145 2.21e-03 -1.47e-01 1.99e-02
Pre-NOTCH Transcription and Translation 67 3.73e-02 1.47e-01 1.66e-01
DAP12 signaling 27 1.87e-01 -1.47e-01 4.78e-01
Polymerase switching on the C-strand of the telomere 25 2.04e-01 -1.47e-01 4.95e-01
Diseases of mitotic cell cycle 37 1.23e-01 -1.47e-01 3.69e-01
Prevention of phagosomal-lysosomal fusion 9 4.47e-01 -1.46e-01 7.38e-01
Induction of Cell-Cell Fusion 12 3.80e-01 1.46e-01 6.85e-01
Gene Silencing by RNA 104 9.97e-03 -1.46e-01 6.29e-02
Regulation of PTEN stability and activity 67 3.86e-02 -1.46e-01 1.70e-01
Synthesis of PE 13 3.62e-01 -1.46e-01 6.67e-01
Toll Like Receptor 3 (TLR3) Cascade 99 1.20e-02 -1.46e-01 7.12e-02
HIV Infection 222 1.80e-04 -1.46e-01 3.54e-03
ROS and RNS production in phagocytes 33 1.47e-01 -1.46e-01 4.10e-01
Serine biosynthesis 9 4.49e-01 1.46e-01 7.39e-01
Processive synthesis on the C-strand of the telomere 19 2.72e-01 -1.46e-01 5.75e-01
Repression of WNT target genes 14 3.46e-01 1.45e-01 6.53e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 2.39e-01 -1.45e-01 5.44e-01
Neurodegenerative Diseases 22 2.39e-01 -1.45e-01 5.44e-01
NFE2L2 regulating tumorigenic genes 10 4.29e-01 1.44e-01 7.25e-01
2-LTR circle formation 7 5.10e-01 -1.44e-01 7.70e-01
RUNX1 regulates transcription of genes involved in interleukin signaling 5 5.78e-01 1.44e-01 8.15e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 4.55e-01 -1.44e-01 7.42e-01
TNFR2 non-canonical NF-kB pathway 95 1.57e-02 -1.43e-01 8.82e-02
Loss of Function of SMAD2/3 in Cancer 7 5.13e-01 -1.43e-01 7.71e-01
MyD88 dependent cascade initiated on endosome 96 1.56e-02 -1.43e-01 8.79e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 96 1.56e-02 -1.43e-01 8.79e-02
Regulation of KIT signaling 16 3.23e-01 1.43e-01 6.26e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 7.51e-02 -1.43e-01 2.70e-01
NOD1/2 Signaling Pathway 33 1.56e-01 -1.43e-01 4.26e-01
DARPP-32 events 24 2.27e-01 -1.42e-01 5.28e-01
Interleukin receptor SHC signaling 23 2.38e-01 -1.42e-01 5.44e-01
Constitutive Signaling by Aberrant PI3K in Cancer 76 3.22e-02 1.42e-01 1.51e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 8 4.86e-01 1.42e-01 7.63e-01
Cellular responses to stress 740 4.96e-11 -1.42e-01 5.83e-09
Relaxin receptors 8 4.88e-01 1.42e-01 7.63e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.96e-01 1.41e-01 6.98e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 2.12e-01 -1.41e-01 5.10e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 2.12e-01 -1.41e-01 5.10e-01
Senescence-Associated Secretory Phenotype (SASP) 74 3.57e-02 -1.41e-01 1.62e-01
Arachidonic acid metabolism 57 6.52e-02 -1.41e-01 2.45e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 2.04e-01 -1.41e-01 4.95e-01
Inactivation of CDC42 and RAC1 8 4.90e-01 1.41e-01 7.63e-01
Formation of RNA Pol II elongation complex 57 6.58e-02 -1.41e-01 2.46e-01
RNA Polymerase II Transcription Elongation 57 6.58e-02 -1.41e-01 2.46e-01
Neurotransmitter release cycle 48 9.16e-02 1.41e-01 3.07e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 20 2.77e-01 1.40e-01 5.78e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 2.25e-01 -1.40e-01 5.25e-01
SUMOylation of DNA damage response and repair proteins 74 3.74e-02 -1.40e-01 1.66e-01
Late Phase of HIV Life Cycle 132 5.52e-03 -1.40e-01 3.92e-02
Transcriptional regulation by RUNX3 93 1.97e-02 -1.40e-01 1.06e-01
Transport of fatty acids 8 4.94e-01 1.40e-01 7.64e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 1.47e-01 -1.40e-01 4.09e-01
Regulation of RUNX2 expression and activity 72 4.08e-02 -1.39e-01 1.76e-01
PERK regulates gene expression 31 1.80e-01 -1.39e-01 4.66e-01
Conjugation of salicylate with glycine 7 5.23e-01 1.39e-01 7.79e-01
Chromosome Maintenance 109 1.21e-02 -1.39e-01 7.13e-02
RUNX3 regulates p14-ARF 10 4.47e-01 1.39e-01 7.38e-01
Platelet sensitization by LDL 17 3.22e-01 -1.39e-01 6.25e-01
Organelle biogenesis and maintenance 274 7.69e-05 -1.39e-01 1.71e-03
SARS-CoV-1 Infection 135 5.58e-03 -1.38e-01 3.94e-02
Caspase activation via Death Receptors in the presence of ligand 16 3.39e-01 -1.38e-01 6.44e-01
Non-integrin membrane-ECM interactions 55 7.65e-02 1.38e-01 2.73e-01
Termination of O-glycan biosynthesis 25 2.32e-01 -1.38e-01 5.36e-01
Erythropoietin activates RAS 14 3.72e-01 1.38e-01 6.77e-01
Response of Mtb to phagocytosis 22 2.63e-01 -1.38e-01 5.65e-01
Signaling by FGFR4 in disease 11 4.29e-01 1.38e-01 7.25e-01
Signaling by NOTCH4 80 3.36e-02 -1.37e-01 1.56e-01
HDMs demethylate histones 18 3.13e-01 -1.37e-01 6.15e-01
RHOBTB GTPase Cycle 34 1.67e-01 -1.37e-01 4.44e-01
Cellular responses to stimuli 754 1.59e-10 -1.37e-01 1.77e-08
Signaling by Retinoic Acid 41 1.30e-01 1.37e-01 3.81e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.19e-01 -1.37e-01 5.18e-01
G alpha (q) signalling events 206 7.50e-04 1.36e-01 9.49e-03
mRNA Editing 10 4.56e-01 -1.36e-01 7.42e-01
IRAK1 recruits IKK complex 12 4.14e-01 -1.36e-01 7.11e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 12 4.14e-01 -1.36e-01 7.11e-01
DAP12 interactions 37 1.52e-01 -1.36e-01 4.19e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 112 1.29e-02 -1.36e-01 7.50e-02
Apoptosis 172 2.11e-03 -1.36e-01 1.95e-02
Defects of platelet adhesion to exposed collagen 8 5.07e-01 1.35e-01 7.69e-01
Infection with Mycobacterium tuberculosis 25 2.41e-01 -1.35e-01 5.48e-01
Processive synthesis on the lagging strand 14 3.81e-01 -1.35e-01 6.85e-01
Interleukin-17 signaling 66 5.79e-02 -1.35e-01 2.25e-01
Nucleotide Excision Repair 107 1.64e-02 -1.34e-01 9.06e-02
Acyl chain remodelling of PS 22 2.76e-01 -1.34e-01 5.77e-01
Collagen degradation 61 7.02e-02 1.34e-01 2.56e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 3.12e-01 1.34e-01 6.15e-01
Synthesis of IP3 and IP4 in the cytosol 25 2.47e-01 -1.34e-01 5.50e-01
MyD88-independent TLR4 cascade 103 1.95e-02 -1.33e-01 1.05e-01
TRIF(TICAM1)-mediated TLR4 signaling 103 1.95e-02 -1.33e-01 1.05e-01
DNA Repair 298 7.71e-05 -1.33e-01 1.71e-03
Acetylcholine inhibits contraction of outer hair cells 5 6.06e-01 1.33e-01 8.27e-01
RNA Polymerase III Transcription Initiation 36 1.67e-01 -1.33e-01 4.44e-01
Sodium/Calcium exchangers 11 4.45e-01 1.33e-01 7.38e-01
TNFR1-induced NF-kappa-B signaling pathway 30 2.09e-01 -1.33e-01 5.05e-01
Attenuation phase 24 2.61e-01 1.32e-01 5.65e-01
Mitochondrial Uncoupling 5 6.09e-01 1.32e-01 8.27e-01
Activated NTRK3 signals through RAS 8 5.18e-01 1.32e-01 7.76e-01
PP2A-mediated dephosphorylation of key metabolic factors 6 5.76e-01 -1.32e-01 8.15e-01
Toll Like Receptor 9 (TLR9) Cascade 100 2.29e-02 -1.32e-01 1.19e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 9 4.94e-01 1.32e-01 7.64e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.94e-01 -1.32e-01 6.95e-01
Signaling by Erythropoietin 25 2.55e-01 1.31e-01 5.58e-01
Protein repair 6 5.78e-01 -1.31e-01 8.15e-01
Inwardly rectifying K+ channels 35 1.80e-01 1.31e-01 4.66e-01
NTRK2 activates RAC1 5 6.12e-01 1.31e-01 8.30e-01
Interleukin-27 signaling 11 4.53e-01 -1.31e-01 7.42e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 3.98e-01 -1.30e-01 6.99e-01
Fc epsilon receptor (FCERI) signaling 127 1.14e-02 -1.30e-01 6.94e-02
Response to metal ions 14 4.00e-01 1.30e-01 7.00e-01
Signaling by Leptin 11 4.56e-01 1.30e-01 7.42e-01
Glutamate and glutamine metabolism 12 4.36e-01 -1.30e-01 7.32e-01
ER to Golgi Anterograde Transport 150 6.10e-03 -1.30e-01 4.24e-02
Bicarbonate transporters 10 4.78e-01 -1.30e-01 7.61e-01
Cellular response to hypoxia 73 5.56e-02 -1.30e-01 2.19e-01
Telomere C-strand (Lagging Strand) Synthesis 33 2.01e-01 -1.29e-01 4.92e-01
Nectin/Necl trans heterodimerization 7 5.56e-01 1.29e-01 8.02e-01
Ca2+ pathway 62 8.04e-02 1.28e-01 2.81e-01
Diseases associated with O-glycosylation of proteins 68 6.76e-02 1.28e-01 2.51e-01
CTLA4 inhibitory signaling 21 3.09e-01 -1.28e-01 6.11e-01
Disorders of transmembrane transporters 170 3.97e-03 -1.28e-01 3.11e-02
MAPK3 (ERK1) activation 10 4.83e-01 -1.28e-01 7.61e-01
Notch-HLH transcription pathway 24 2.78e-01 1.28e-01 5.78e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 4.84e-01 1.28e-01 7.62e-01
Regulation of signaling by NODAL 9 5.07e-01 -1.28e-01 7.69e-01
Acyl chain remodelling of PC 27 2.51e-01 -1.28e-01 5.55e-01
Laminin interactions 28 2.42e-01 1.28e-01 5.49e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 8 5.32e-01 -1.28e-01 7.87e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 20 3.24e-01 -1.27e-01 6.26e-01
Chemokine receptors bind chemokines 53 1.09e-01 1.27e-01 3.43e-01
FCGR3A-mediated phagocytosis 56 1.01e-01 -1.27e-01 3.24e-01
Leishmania phagocytosis 56 1.01e-01 -1.27e-01 3.24e-01
Parasite infection 56 1.01e-01 -1.27e-01 3.24e-01
Processing of Intronless Pre-mRNAs 19 3.40e-01 -1.26e-01 6.45e-01
Inhibition of DNA recombination at telomere 43 1.52e-01 -1.26e-01 4.19e-01
RNA Polymerase III Abortive And Retractive Initiation 41 1.63e-01 -1.26e-01 4.38e-01
RNA Polymerase III Transcription 41 1.63e-01 -1.26e-01 4.38e-01
EGFR Transactivation by Gastrin 9 5.13e-01 1.26e-01 7.71e-01
MAPK6/MAPK4 signaling 90 3.92e-02 -1.26e-01 1.72e-01
Degradation of cysteine and homocysteine 14 4.15e-01 1.26e-01 7.13e-01
Processing of Capped Intronless Pre-mRNA 28 2.51e-01 -1.25e-01 5.56e-01
Regulation of TP53 Activity through Phosphorylation 89 4.14e-02 -1.25e-01 1.78e-01
Signaling by CSF3 (G-CSF) 30 2.36e-01 -1.25e-01 5.42e-01
Aspartate and asparagine metabolism 11 4.74e-01 1.25e-01 7.61e-01
GRB2 events in EGFR signaling 12 4.56e-01 1.24e-01 7.42e-01
Dissolution of Fibrin Clot 13 4.38e-01 1.24e-01 7.32e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 91 4.12e-02 -1.24e-01 1.77e-01
tRNA Aminoacylation 40 1.75e-01 -1.24e-01 4.60e-01
COPI-mediated anterograde transport 100 3.27e-02 -1.24e-01 1.53e-01
Formation of tubulin folding intermediates by CCT/TriC 25 2.85e-01 -1.23e-01 5.85e-01
RSK activation 5 6.33e-01 -1.23e-01 8.42e-01
mRNA Capping 28 2.58e-01 -1.23e-01 5.61e-01
Chondroitin sulfate biosynthesis 18 3.65e-01 1.23e-01 6.71e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 5.47e-01 -1.23e-01 7.97e-01
Early SARS-CoV-2 Infection Events 34 2.15e-01 1.23e-01 5.14e-01
Transport and synthesis of PAPS 6 6.03e-01 1.23e-01 8.27e-01
Cellular response to chemical stress 202 2.66e-03 -1.23e-01 2.32e-02
Sensory processing of sound by inner hair cells of the cochlea 62 9.52e-02 -1.23e-01 3.16e-01
Disorders of Developmental Biology 11 4.82e-01 1.22e-01 7.61e-01
Disorders of Nervous System Development 11 4.82e-01 1.22e-01 7.61e-01
Loss of function of MECP2 in Rett syndrome 11 4.82e-01 1.22e-01 7.61e-01
Pervasive developmental disorders 11 4.82e-01 1.22e-01 7.61e-01
Formation of Incision Complex in GG-NER 40 1.81e-01 -1.22e-01 4.68e-01
Translesion synthesis by REV1 16 3.98e-01 -1.22e-01 6.99e-01
Glycosaminoglycan metabolism 120 2.11e-02 1.22e-01 1.13e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.00e-01 -1.22e-01 3.24e-01
Signaling by ERBB4 57 1.12e-01 1.22e-01 3.46e-01
Scavenging by Class F Receptors 6 6.06e-01 -1.22e-01 8.27e-01
Processing of DNA double-strand break ends 75 7.04e-02 -1.21e-01 2.56e-01
Global Genome Nucleotide Excision Repair (GG-NER) 81 6.02e-02 -1.21e-01 2.31e-01
Interleukin-1 family signaling 146 1.18e-02 -1.21e-01 7.01e-02
SUMOylation of DNA methylation proteins 16 4.03e-01 1.21e-01 7.02e-01
Translesion synthesis by POLI 17 3.90e-01 -1.20e-01 6.90e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 72 7.76e-02 -1.20e-01 2.76e-01
Phenylalanine and tyrosine metabolism 11 4.90e-01 -1.20e-01 7.63e-01
Aspirin ADME 38 2.00e-01 1.20e-01 4.92e-01
Inactivation of CSF3 (G-CSF) signaling 25 2.99e-01 -1.20e-01 5.99e-01
Digestion and absorption 22 3.30e-01 1.20e-01 6.33e-01
TICAM1-dependent activation of IRF3/IRF7 12 4.73e-01 -1.20e-01 7.61e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 15 4.23e-01 -1.20e-01 7.18e-01
Muscarinic acetylcholine receptors 5 6.44e-01 1.19e-01 8.52e-01
Hedgehog ‘off’ state 110 3.08e-02 -1.19e-01 1.46e-01
TAK1-dependent IKK and NF-kappa-B activation 41 1.87e-01 -1.19e-01 4.78e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 3.58e-01 1.19e-01 6.66e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 6.46e-01 1.19e-01 8.53e-01
Glycogen storage diseases 15 4.26e-01 -1.19e-01 7.21e-01
Deubiquitination 244 1.42e-03 -1.19e-01 1.46e-02
Regulation of actin dynamics for phagocytic cup formation 57 1.22e-01 -1.19e-01 3.66e-01
Defective CHST14 causes EDS, musculocontractural type 7 5.87e-01 -1.19e-01 8.20e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 7 5.87e-01 1.19e-01 8.20e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 5.62e-01 1.18e-01 8.08e-01
Condensation of Prophase Chromosomes 36 2.19e-01 -1.18e-01 5.18e-01
AKT phosphorylates targets in the nucleus 9 5.39e-01 -1.18e-01 7.92e-01
STAT3 nuclear events downstream of ALK signaling 10 5.18e-01 -1.18e-01 7.76e-01
HS-GAG degradation 21 3.49e-01 1.18e-01 6.55e-01
Interleukin-18 signaling 8 5.64e-01 1.18e-01 8.08e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 106 3.64e-02 -1.18e-01 1.64e-01
Toll Like Receptor TLR6:TLR2 Cascade 106 3.64e-02 -1.18e-01 1.64e-01
COPII-mediated vesicle transport 65 1.02e-01 -1.17e-01 3.27e-01
Formation of the Editosome 8 5.66e-01 -1.17e-01 8.08e-01
mRNA Editing: C to U Conversion 8 5.66e-01 -1.17e-01 8.08e-01
Dual Incision in GG-NER 39 2.06e-01 -1.17e-01 4.99e-01
Programmed Cell Death 202 4.17e-03 -1.17e-01 3.19e-02
Insulin receptor recycling 28 2.85e-01 -1.17e-01 5.85e-01
RHO GTPases activate CIT 19 3.79e-01 -1.17e-01 6.83e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 7 5.93e-01 -1.17e-01 8.20e-01
Ub-specific processing proteases 175 7.80e-03 -1.17e-01 5.23e-02
Nucleotide salvage 21 3.55e-01 -1.17e-01 6.63e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 5.23e-01 -1.17e-01 7.79e-01
Formation of the cornified envelope 123 2.58e-02 1.16e-01 1.28e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 2.27e-01 -1.16e-01 5.28e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 5.05e-01 -1.16e-01 7.68e-01
Biosynthesis of specialized proresolving mediators (SPMs) 19 3.82e-01 1.16e-01 6.85e-01
DNA Double Strand Break Response 56 1.34e-01 -1.16e-01 3.86e-01
Cilium Assembly 190 6.00e-03 -1.16e-01 4.18e-02
Intrinsic Pathway for Apoptosis 53 1.46e-01 -1.16e-01 4.07e-01
Interleukin-37 signaling 20 3.72e-01 1.15e-01 6.77e-01
Pentose phosphate pathway 12 4.89e-01 -1.15e-01 7.63e-01
Protein-protein interactions at synapses 78 7.90e-02 1.15e-01 2.78e-01
Tryptophan catabolism 14 4.57e-01 1.15e-01 7.43e-01
Nef mediated downregulation of MHC class I complex cell surface expression 8 5.74e-01 1.15e-01 8.15e-01
Regulation of TLR by endogenous ligand 21 3.63e-01 1.15e-01 6.68e-01
Cytosolic iron-sulfur cluster assembly 12 4.93e-01 -1.14e-01 7.63e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 4.43e-01 1.14e-01 7.36e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 1.66e-01 -1.14e-01 4.43e-01
Calnexin/calreticulin cycle 26 3.14e-01 -1.14e-01 6.15e-01
Interleukin-7 signaling 21 3.65e-01 1.14e-01 6.71e-01
COPI-dependent Golgi-to-ER retrograde traffic 98 5.10e-02 -1.14e-01 2.07e-01
FGFR1b ligand binding and activation 8 5.77e-01 1.14e-01 8.15e-01
RHOT2 GTPase cycle 7 6.02e-01 -1.14e-01 8.26e-01
Leading Strand Synthesis 13 4.78e-01 -1.14e-01 7.61e-01
Polymerase switching 13 4.78e-01 -1.14e-01 7.61e-01
Disinhibition of SNARE formation 5 6.60e-01 1.14e-01 8.59e-01
Diseases of hemostasis 17 4.18e-01 1.13e-01 7.15e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.46e-01 -1.13e-01 5.50e-01
FLT3 signaling by CBL mutants 7 6.04e-01 -1.13e-01 8.27e-01
Signal regulatory protein family interactions 15 4.49e-01 -1.13e-01 7.38e-01
KEAP1-NFE2L2 pathway 123 3.05e-02 -1.13e-01 1.45e-01
Fcgamma receptor (FCGR) dependent phagocytosis 82 7.71e-02 -1.13e-01 2.75e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 4.81e-01 -1.13e-01 7.61e-01
Gluconeogenesis 34 2.55e-01 -1.13e-01 5.58e-01
eNOS activation 10 5.38e-01 1.13e-01 7.92e-01
Estrogen biosynthesis 6 6.33e-01 -1.12e-01 8.42e-01
Negative regulation of FGFR3 signaling 28 3.04e-01 1.12e-01 6.04e-01
IFNG signaling activates MAPKs 8 5.83e-01 1.12e-01 8.18e-01
Spry regulation of FGF signaling 16 4.38e-01 -1.12e-01 7.32e-01
mTORC1-mediated signalling 23 3.53e-01 -1.12e-01 6.61e-01
MET activates RAP1 and RAC1 11 5.21e-01 -1.12e-01 7.78e-01
Nuclear events stimulated by ALK signaling in cancer 34 2.60e-01 1.12e-01 5.63e-01
Recognition of DNA damage by PCNA-containing replication complex 29 2.99e-01 -1.12e-01 5.99e-01
RHO GTPases activate IQGAPs 30 2.90e-01 -1.12e-01 5.91e-01
Sodium-coupled sulphate, di- and tri-carboxylate transporters 5 6.67e-01 -1.11e-01 8.63e-01
Lipophagy 9 5.64e-01 -1.11e-01 8.08e-01
Viral Infection Pathways 749 2.27e-07 -1.11e-01 8.89e-06
Nonhomologous End-Joining (NHEJ) 46 1.92e-01 -1.11e-01 4.84e-01
Interaction between L1 and Ankyrins 30 2.93e-01 -1.11e-01 5.93e-01
Lagging Strand Synthesis 19 4.02e-01 -1.11e-01 7.02e-01
Sensory processing of sound 69 1.11e-01 -1.11e-01 3.46e-01
Acyl chain remodelling of PE 29 3.01e-01 -1.11e-01 6.01e-01
Signaling by FGFR1 51 1.71e-01 1.11e-01 4.52e-01
POLB-Dependent Long Patch Base Excision Repair 8 5.88e-01 -1.11e-01 8.20e-01
Asparagine N-linked glycosylation 297 1.05e-03 -1.11e-01 1.17e-02
Regulation of signaling by CBL 22 3.70e-01 -1.10e-01 6.77e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 5.47e-01 -1.10e-01 7.97e-01
Aflatoxin activation and detoxification 19 4.06e-01 -1.10e-01 7.05e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 27 3.23e-01 1.10e-01 6.26e-01
Peptide hormone metabolism 81 8.77e-02 1.10e-01 2.99e-01
Cyclin D associated events in G1 46 1.98e-01 -1.10e-01 4.90e-01
G1 Phase 46 1.98e-01 -1.10e-01 4.90e-01
Gamma-carboxylation of protein precursors 8 5.91e-01 1.10e-01 8.20e-01
RUNX2 regulates genes involved in cell migration 8 5.91e-01 1.10e-01 8.20e-01
Signaling by FGFR2 IIIa TM 19 4.09e-01 -1.09e-01 7.07e-01
ER Quality Control Compartment (ERQC) 21 3.86e-01 -1.09e-01 6.89e-01
Transmission across Chemical Synapses 255 2.72e-03 1.09e-01 2.36e-02
HCMV Infection 123 3.68e-02 -1.09e-01 1.65e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 2.11e-01 -1.09e-01 5.08e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 51 1.78e-01 -1.09e-01 4.64e-01
Glucocorticoid biosynthesis 9 5.71e-01 1.09e-01 8.14e-01
Glyoxylate metabolism and glycine degradation 30 3.02e-01 -1.09e-01 6.02e-01
Activation of the pre-replicative complex 31 2.94e-01 -1.09e-01 5.95e-01
Ubiquinol biosynthesis 8 5.94e-01 -1.09e-01 8.20e-01
Translesion Synthesis by POLH 18 4.25e-01 -1.09e-01 7.19e-01
tRNA modification in the nucleus and cytosol 41 2.29e-01 -1.09e-01 5.30e-01
SHC1 events in EGFR signaling 13 4.98e-01 1.08e-01 7.65e-01
Apoptosis induced DNA fragmentation 13 4.99e-01 -1.08e-01 7.65e-01
Ephrin signaling 17 4.39e-01 -1.08e-01 7.32e-01
Toll Like Receptor 2 (TLR2) Cascade 109 5.07e-02 -1.08e-01 2.07e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 5.07e-02 -1.08e-01 2.07e-01
Apoptotic cleavage of cell adhesion proteins 11 5.35e-01 1.08e-01 7.90e-01
Signaling by WNT in cancer 32 2.91e-01 1.08e-01 5.91e-01
Transport of nucleotide sugars 8 5.97e-01 1.08e-01 8.22e-01
MAPK1 (ERK2) activation 9 5.75e-01 -1.08e-01 8.15e-01
APC truncation mutants have impaired AXIN binding 13 5.01e-01 -1.08e-01 7.65e-01
AXIN missense mutants destabilize the destruction complex 13 5.01e-01 -1.08e-01 7.65e-01
Signaling by AMER1 mutants 13 5.01e-01 -1.08e-01 7.65e-01
Signaling by APC mutants 13 5.01e-01 -1.08e-01 7.65e-01
Signaling by AXIN mutants 13 5.01e-01 -1.08e-01 7.65e-01
Truncations of AMER1 destabilize the destruction complex 13 5.01e-01 -1.08e-01 7.65e-01
Negative regulation of FGFR2 signaling 33 2.84e-01 1.08e-01 5.84e-01
RHO GTPases activate PKNs 56 1.65e-01 -1.07e-01 4.42e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 9 5.78e-01 1.07e-01 8.15e-01
Scavenging by Class B Receptors 6 6.50e-01 1.07e-01 8.53e-01
Interleukin-6 signaling 11 5.40e-01 -1.07e-01 7.93e-01
RHO GTPases activate PAKs 19 4.21e-01 -1.07e-01 7.16e-01
Telomere Extension By Telomerase 22 3.87e-01 -1.07e-01 6.89e-01
HCMV Early Events 99 6.70e-02 -1.07e-01 2.49e-01
Innate Immune System 987 1.52e-08 -1.06e-01 8.42e-07
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 4.48e-01 -1.06e-01 7.38e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 4.48e-01 -1.06e-01 7.38e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 2.23e-01 -1.06e-01 5.24e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.78e-01 -1.06e-01 6.83e-01
CTNNB1 S33 mutants aren’t phosphorylated 14 4.92e-01 -1.06e-01 7.63e-01
CTNNB1 S37 mutants aren’t phosphorylated 14 4.92e-01 -1.06e-01 7.63e-01
CTNNB1 S45 mutants aren’t phosphorylated 14 4.92e-01 -1.06e-01 7.63e-01
CTNNB1 T41 mutants aren’t phosphorylated 14 4.92e-01 -1.06e-01 7.63e-01
Signaling by CTNNB1 phospho-site mutants 14 4.92e-01 -1.06e-01 7.63e-01
Signaling by GSK3beta mutants 14 4.92e-01 -1.06e-01 7.63e-01
Interleukin-2 signaling 11 5.44e-01 -1.06e-01 7.95e-01
O-linked glycosylation 110 5.57e-02 1.06e-01 2.19e-01
N-Glycan antennae elongation 15 4.79e-01 1.06e-01 7.61e-01
Dual incision in TC-NER 63 1.48e-01 -1.05e-01 4.10e-01
DCC mediated attractive signaling 14 4.95e-01 -1.05e-01 7.64e-01
Pexophagy 10 5.64e-01 -1.05e-01 8.08e-01
Glycogen breakdown (glycogenolysis) 11 5.46e-01 1.05e-01 7.97e-01
PTK6 promotes HIF1A stabilization 7 6.30e-01 1.05e-01 8.40e-01
RHOJ GTPase cycle 50 1.98e-01 1.05e-01 4.90e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 2.62e-01 -1.05e-01 5.65e-01
Organic cation/anion/zwitterion transport 15 4.83e-01 -1.05e-01 7.61e-01
Transport to the Golgi and subsequent modification 181 1.53e-02 -1.04e-01 8.73e-02
RHOBTB1 GTPase cycle 22 3.97e-01 -1.04e-01 6.98e-01
Interconversion of nucleotide di- and triphosphates 29 3.31e-01 -1.04e-01 6.34e-01
ARMS-mediated activation 7 6.33e-01 -1.04e-01 8.42e-01
Mitochondrial tRNA aminoacylation 20 4.20e-01 -1.04e-01 7.15e-01
Plasma lipoprotein assembly 19 4.33e-01 1.04e-01 7.28e-01
RHOBTB2 GTPase cycle 22 4.00e-01 -1.04e-01 7.00e-01
RHOF GTPase cycle 40 2.58e-01 1.03e-01 5.60e-01
Meiotic recombination 50 2.06e-01 -1.03e-01 4.99e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 29 3.36e-01 -1.03e-01 6.41e-01
PCNA-Dependent Long Patch Base Excision Repair 21 4.14e-01 -1.03e-01 7.11e-01
SUMOylation of immune response proteins 11 5.55e-01 -1.03e-01 8.02e-01
Recycling pathway of L1 42 2.49e-01 -1.03e-01 5.53e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 3.47e-01 -1.03e-01 6.53e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 55 1.88e-01 -1.03e-01 4.78e-01
PKR-mediated signaling 70 1.38e-01 -1.03e-01 3.95e-01
PIWI-interacting RNA (piRNA) biogenesis 29 3.41e-01 -1.02e-01 6.46e-01
Long-term potentiation 22 4.06e-01 1.02e-01 7.05e-01
Phosphorylation of CD3 and TCR zeta chains 16 4.80e-01 1.02e-01 7.61e-01
Selective autophagy 76 1.25e-01 -1.02e-01 3.73e-01
Nef Mediated CD4 Down-regulation 9 5.98e-01 1.02e-01 8.22e-01
Activation of RAC1 downstream of NMDARs 7 6.42e-01 -1.02e-01 8.51e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 76 1.27e-01 -1.01e-01 3.77e-01
Prolactin receptor signaling 13 5.28e-01 1.01e-01 7.82e-01
Deactivation of the beta-catenin transactivating complex 39 2.76e-01 1.01e-01 5.77e-01
Synthesis, secretion, and deacylation of Ghrelin 18 4.59e-01 1.01e-01 7.45e-01
SUMOylation of chromatin organization proteins 57 1.89e-01 -1.01e-01 4.79e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 198 1.51e-02 -1.00e-01 8.63e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.31e-01 -1.00e-01 3.82e-01
Signal attenuation 10 5.85e-01 9.98e-02 8.19e-01
Intraflagellar transport 51 2.18e-01 -9.97e-02 5.18e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.64e-01 -9.95e-02 5.65e-01
HIV Transcription Elongation 42 2.64e-01 -9.95e-02 5.65e-01
Tat-mediated elongation of the HIV-1 transcript 42 2.64e-01 -9.95e-02 5.65e-01
IL-6-type cytokine receptor ligand interactions 17 4.77e-01 9.95e-02 7.61e-01
TBC/RABGAPs 41 2.71e-01 -9.94e-02 5.74e-01
Neutrophil degranulation 453 2.86e-04 -9.94e-02 5.06e-03
Formation of Fibrin Clot (Clotting Cascade) 37 2.96e-01 9.93e-02 5.96e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 6.06e-01 -9.93e-02 8.27e-01
Post-translational modification: synthesis of GPI-anchored proteins 90 1.04e-01 9.92e-02 3.33e-01
Biotin transport and metabolism 10 5.88e-01 9.88e-02 8.20e-01
Interleukin-2 family signaling 39 2.86e-01 -9.87e-02 5.86e-01
Signaling by ERBB2 ECD mutants 16 4.95e-01 9.85e-02 7.64e-01
Diseases associated with surfactant metabolism 9 6.09e-01 9.85e-02 8.27e-01
Activation of the phototransduction cascade 11 5.72e-01 9.83e-02 8.14e-01
Sodium-coupled phosphate cotransporters 5 7.03e-01 -9.83e-02 8.88e-01
TNFR1-induced proapoptotic signaling 24 4.05e-01 -9.83e-02 7.04e-01
RHOQ GTPase cycle 57 2.00e-01 9.82e-02 4.92e-01
Mucopolysaccharidoses 10 5.91e-01 9.81e-02 8.20e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 10 5.92e-01 -9.78e-02 8.20e-01
Serotonin Neurotransmitter Release Cycle 17 4.85e-01 9.77e-02 7.62e-01
Metabolism of porphyrins 26 3.88e-01 -9.77e-02 6.89e-01
ECM proteoglycans 73 1.50e-01 9.75e-02 4.14e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 2.81e-01 -9.73e-02 5.82e-01
Infectious disease 931 4.94e-07 -9.72e-02 1.86e-05
Atorvastatin ADME 9 6.14e-01 9.70e-02 8.30e-01
Synthesis of PIPs at the Golgi membrane 17 4.90e-01 9.68e-02 7.63e-01
Meiosis 80 1.35e-01 -9.67e-02 3.87e-01
Formation of WDR5-containing histone-modifying complexes 38 3.02e-01 -9.67e-02 6.02e-01
Extracellular matrix organization 291 4.63e-03 9.65e-02 3.43e-02
Collagen formation 88 1.19e-01 9.61e-02 3.60e-01
TRIF-mediated programmed cell death 9 6.18e-01 9.60e-02 8.30e-01
Golgi-to-ER retrograde transport 132 5.69e-02 -9.60e-02 2.22e-01
Androgen biosynthesis 11 5.82e-01 -9.57e-02 8.18e-01
SARS-CoV-2 Infection 273 6.48e-03 -9.57e-02 4.45e-02
Cellular hexose transport 22 4.38e-01 -9.56e-02 7.32e-01
VEGFR2 mediated cell proliferation 19 4.71e-01 9.56e-02 7.59e-01
RUNX3 regulates WNT signaling 8 6.40e-01 9.55e-02 8.50e-01
Neurotransmitter receptors and postsynaptic signal transmission 192 2.26e-02 9.54e-02 1.18e-01
Recycling of bile acids and salts 18 4.85e-01 -9.51e-02 7.62e-01
DNA Damage Bypass 46 2.65e-01 -9.49e-02 5.66e-01
Asymmetric localization of PCP proteins 63 1.93e-01 -9.49e-02 4.84e-01
Negative regulation of FGFR1 signaling 32 3.53e-01 9.48e-02 6.61e-01
RNA Polymerase II Pre-transcription Events 77 1.52e-01 -9.45e-02 4.19e-01
Beta-catenin phosphorylation cascade 16 5.13e-01 -9.44e-02 7.71e-01
Activation of G protein gated Potassium channels 29 3.79e-01 9.44e-02 6.83e-01
G protein gated Potassium channels 29 3.79e-01 9.44e-02 6.83e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 3.79e-01 9.44e-02 6.83e-01
HSF1 activation 26 4.08e-01 9.37e-02 7.06e-01
B-WICH complex positively regulates rRNA expression 54 2.34e-01 -9.36e-02 5.39e-01
Defective RIPK1-mediated regulated necrosis 7 6.68e-01 9.36e-02 8.63e-01
Pre-NOTCH Expression and Processing 83 1.43e-01 9.31e-02 4.00e-01
NFE2L2 regulating ER-stress associated genes 5 7.19e-01 9.30e-02 8.96e-01
Negative regulation of MET activity 20 4.72e-01 -9.30e-02 7.60e-01
Extension of Telomeres 49 2.60e-01 -9.29e-02 5.64e-01
VLDL assembly 5 7.19e-01 9.28e-02 8.96e-01
Metabolism of amino acids and derivatives 351 2.82e-03 -9.28e-02 2.41e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 6.94e-01 -9.27e-02 8.83e-01
Retrograde neurotrophin signalling 14 5.49e-01 9.26e-02 7.98e-01
Protein folding 95 1.19e-01 -9.25e-02 3.60e-01
IRAK4 deficiency (TLR2/4) 17 5.09e-01 9.25e-02 7.70e-01
Cell junction organization 113 8.95e-02 9.25e-02 3.02e-01
Telomere Maintenance 86 1.38e-01 -9.24e-02 3.95e-01
Collagen chain trimerization 42 3.03e-01 9.19e-02 6.02e-01
Activated NTRK2 signals through FYN 7 6.74e-01 9.19e-02 8.65e-01
Neurotoxicity of clostridium toxins 10 6.16e-01 9.17e-02 8.30e-01
Nuclear Events (kinase and transcription factor activation) 59 2.24e-01 -9.15e-02 5.25e-01
Loss of Function of TGFBR1 in Cancer 7 6.75e-01 -9.14e-02 8.65e-01
Formation of paraxial mesoderm 67 1.96e-01 -9.13e-02 4.90e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 5.54e-01 -9.12e-02 8.02e-01
Interleukin-10 signaling 41 3.14e-01 -9.08e-02 6.16e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 2.76e-01 -9.08e-02 5.77e-01
Toxicity of botulinum toxin type D (botD) 5 7.25e-01 9.07e-02 9.01e-01
Toxicity of botulinum toxin type F (botF) 5 7.25e-01 9.07e-02 9.01e-01
Formation of TC-NER Pre-Incision Complex 51 2.63e-01 -9.06e-02 5.65e-01
Retrograde transport at the Trans-Golgi-Network 47 2.83e-01 -9.05e-02 5.84e-01
Signaling by Insulin receptor 79 1.64e-01 9.05e-02 4.41e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 5.59e-01 -9.01e-02 8.06e-01
Regulated Necrosis 56 2.45e-01 -8.98e-02 5.50e-01
Pregnenolone biosynthesis 12 5.90e-01 8.98e-02 8.20e-01
TRP channels 27 4.19e-01 8.98e-02 7.15e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 5.76e-01 8.95e-02 8.15e-01
Downregulation of ERBB2:ERBB3 signaling 13 5.77e-01 -8.93e-02 8.15e-01
VEGFR2 mediated vascular permeability 26 4.32e-01 8.90e-02 7.27e-01
Branched-chain amino acid catabolism 20 4.92e-01 8.89e-02 7.63e-01
p75NTR signals via NF-kB 15 5.51e-01 -8.89e-02 8.01e-01
Metabolism of nucleotides 93 1.40e-01 -8.86e-02 3.96e-01
Signaling by Interleukins 429 1.68e-03 -8.84e-02 1.65e-02
Regulation of IFNA/IFNB signaling 18 5.19e-01 8.79e-02 7.76e-01
VxPx cargo-targeting to cilium 20 4.97e-01 8.78e-02 7.65e-01
Mismatch Repair 15 5.57e-01 -8.76e-02 8.03e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.50e-01 -8.73e-02 7.39e-01
Amino acids regulate mTORC1 51 2.81e-01 -8.72e-02 5.82e-01
Biosynthesis of E-series 18(S)-resolvins 5 7.36e-01 8.71e-02 9.04e-01
NADE modulates death signalling 5 7.36e-01 -8.71e-02 9.04e-01
Regulation of NF-kappa B signaling 17 5.35e-01 -8.70e-02 7.90e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 6.18e-01 8.69e-02 8.30e-01
NRAGE signals death through JNK 53 2.75e-01 8.67e-02 5.76e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 8 6.71e-01 8.67e-02 8.64e-01
The role of Nef in HIV-1 replication and disease pathogenesis 26 4.44e-01 8.66e-02 7.37e-01
Packaging Of Telomere Ends 29 4.20e-01 -8.66e-02 7.15e-01
Chaperonin-mediated protein folding 89 1.58e-01 -8.66e-02 4.29e-01
Role of second messengers in netrin-1 signaling 9 6.53e-01 8.65e-02 8.54e-01
CS/DS degradation 12 6.04e-01 -8.64e-02 8.27e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 8 6.73e-01 8.63e-02 8.65e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 2.77e-01 -8.63e-02 5.78e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 70 2.13e-01 -8.61e-02 5.10e-01
Activation of gene expression by SREBF (SREBP) 41 3.41e-01 -8.59e-02 6.46e-01
Downregulation of TGF-beta receptor signaling 26 4.49e-01 -8.59e-02 7.38e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 3.20e-01 8.57e-02 6.22e-01
Diseases of programmed cell death 66 2.29e-01 -8.56e-02 5.30e-01
Glucuronidation 20 5.08e-01 8.55e-02 7.70e-01
G alpha (s) signalling events 155 6.70e-02 8.52e-02 2.49e-01
MyD88 deficiency (TLR2/4) 16 5.55e-01 8.52e-02 8.02e-01
Apoptotic cleavage of cellular proteins 35 3.84e-01 -8.50e-02 6.87e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 9 6.60e-01 -8.48e-02 8.59e-01
SUMOylation of transcription factors 20 5.13e-01 8.44e-02 7.71e-01
Negative regulation of FGFR4 signaling 30 4.24e-01 8.44e-02 7.19e-01
Negative regulation of the PI3K/AKT network 110 1.26e-01 8.43e-02 3.77e-01
Cleavage of the damaged purine 33 4.03e-01 -8.41e-02 7.02e-01
Depurination 33 4.03e-01 -8.41e-02 7.02e-01
Recognition and association of DNA glycosylase with site containing an affected purine 33 4.03e-01 -8.41e-02 7.02e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 29 4.35e-01 -8.38e-02 7.30e-01
N-glycan trimming and elongation in the cis-Golgi 5 7.46e-01 -8.36e-02 9.10e-01
Cardiac conduction 125 1.07e-01 8.35e-02 3.39e-01
Assembly and cell surface presentation of NMDA receptors 40 3.61e-01 8.34e-02 6.67e-01
Signaling by TGF-beta Receptor Complex 92 1.68e-01 -8.32e-02 4.44e-01
Molecules associated with elastic fibres 37 3.81e-01 8.32e-02 6.85e-01
trans-Golgi Network Vesicle Budding 67 2.40e-01 -8.31e-02 5.45e-01
SARS-CoV Infections 384 5.26e-03 -8.30e-02 3.77e-02
Membrane binding and targetting of GAG proteins 14 5.92e-01 -8.28e-02 8.20e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 5.92e-01 -8.28e-02 8.20e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 7.49e-01 8.27e-02 9.10e-01
Hedgehog ‘on’ state 85 1.89e-01 -8.25e-02 4.78e-01
Fatty acid metabolism 171 6.28e-02 -8.25e-02 2.39e-01
MECP2 regulates transcription of neuronal ligands 7 7.06e-01 8.23e-02 8.91e-01
Carnitine metabolism 13 6.07e-01 8.23e-02 8.27e-01
Defective HLCS causes multiple carboxylase deficiency 7 7.07e-01 8.22e-02 8.91e-01
RHOD GTPase cycle 49 3.20e-01 8.20e-02 6.23e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 3.88e-01 8.20e-02 6.89e-01
Signaling by FGFR3 39 3.77e-01 8.18e-02 6.83e-01
Signaling by FGFR4 40 3.72e-01 8.16e-02 6.77e-01
Beta defensins 24 4.90e-01 8.15e-02 7.63e-01
Reproduction 117 1.29e-01 -8.13e-02 3.79e-01
HATs acetylate histones 97 1.66e-01 -8.13e-02 4.43e-01
Signaling by NTRK2 (TRKB) 25 4.82e-01 8.13e-02 7.61e-01
FOXO-mediated transcription of cell death genes 15 5.86e-01 8.12e-02 8.20e-01
Toll Like Receptor 4 (TLR4) Cascade 138 1.00e-01 -8.11e-02 3.24e-01
Signaling by PDGF 57 2.90e-01 8.11e-02 5.91e-01
Axon guidance 527 1.47e-03 -8.10e-02 1.49e-02
Cleavage of the damaged pyrimidine 38 3.89e-01 -8.08e-02 6.89e-01
Depyrimidination 38 3.89e-01 -8.08e-02 6.89e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 38 3.89e-01 -8.08e-02 6.89e-01
Mitochondrial calcium ion transport 21 5.22e-01 -8.07e-02 7.78e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 4.52e-01 8.07e-02 7.41e-01
Trafficking of AMPA receptors 29 4.52e-01 8.07e-02 7.41e-01
Drug ADME 97 1.70e-01 8.07e-02 4.48e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.44e-01 -8.05e-02 8.52e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 103 1.59e-01 8.04e-02 4.30e-01
Uptake and function of anthrax toxins 11 6.44e-01 -8.04e-02 8.52e-01
RAB GEFs exchange GTP for GDP on RABs 81 2.11e-01 -8.03e-02 5.09e-01
CLEC7A (Dectin-1) induces NFAT activation 11 6.45e-01 -8.03e-02 8.52e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 2.75e-01 -8.02e-02 5.76e-01
Endogenous sterols 26 4.81e-01 -7.99e-02 7.61e-01
Initial triggering of complement 21 5.26e-01 -7.98e-02 7.81e-01
Rab regulation of trafficking 111 1.48e-01 -7.95e-02 4.10e-01
p75NTR regulates axonogenesis 9 6.80e-01 -7.95e-02 8.70e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 6.08e-01 -7.91e-02 8.27e-01
MAPK1/MAPK3 signaling 269 2.60e-02 -7.89e-02 1.28e-01
Digestion of dietary lipid 7 7.18e-01 7.87e-02 8.96e-01
Elastic fibre formation 44 3.67e-01 7.87e-02 6.72e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 45 3.62e-01 -7.86e-02 6.67e-01
Defective CSF2RA causes SMDP4 7 7.20e-01 -7.84e-02 8.96e-01
Defective CSF2RB causes SMDP5 7 7.20e-01 -7.84e-02 8.96e-01
Transcriptional Regulation by TP53 351 1.17e-02 -7.84e-02 7.01e-02
Vitamin B2 (riboflavin) metabolism 7 7.20e-01 7.82e-02 8.96e-01
Neurexins and neuroligins 52 3.30e-01 7.81e-02 6.33e-01
Base-Excision Repair, AP Site Formation 40 3.93e-01 -7.80e-02 6.95e-01
Phenylalanine metabolism 6 7.41e-01 -7.80e-02 9.07e-01
Interleukin-23 signaling 9 6.86e-01 7.79e-02 8.75e-01
Organic cation transport 10 6.70e-01 7.78e-02 8.64e-01
EPH-Ephrin signaling 90 2.02e-01 -7.78e-02 4.95e-01
Digestion 17 5.80e-01 7.75e-02 8.17e-01
Cellular Senescence 159 9.19e-02 -7.75e-02 3.08e-01
Amyloid fiber formation 73 2.53e-01 7.74e-02 5.56e-01
Extra-nuclear estrogen signaling 73 2.55e-01 7.70e-02 5.58e-01
Glycosphingolipid biosynthesis 19 5.61e-01 7.70e-02 8.08e-01
Regulation of TP53 Activity through Acetylation 28 4.81e-01 -7.69e-02 7.61e-01
Sema3A PAK dependent Axon repulsion 14 6.18e-01 -7.69e-02 8.30e-01
DNA Damage/Telomere Stress Induced Senescence 57 3.19e-01 -7.64e-02 6.21e-01
G alpha (z) signalling events 48 3.60e-01 7.63e-02 6.67e-01
Sodium/Proton exchangers 7 7.27e-01 7.62e-02 9.02e-01
RET signaling 41 4.00e-01 7.60e-02 7.00e-01
MicroRNA (miRNA) biogenesis 26 5.02e-01 -7.60e-02 7.66e-01
Activation of GABAB receptors 43 3.89e-01 7.60e-02 6.89e-01
GABA B receptor activation 43 3.89e-01 7.60e-02 6.89e-01
DNA strand elongation 31 4.64e-01 -7.59e-02 7.52e-01
Proton-coupled monocarboxylate transport 6 7.48e-01 7.56e-02 9.10e-01
Downregulation of ERBB2 signaling 29 4.82e-01 7.53e-02 7.61e-01
Adenylate cyclase activating pathway 10 6.81e-01 7.51e-02 8.70e-01
RAF/MAP kinase cascade 263 3.63e-02 -7.50e-02 1.64e-01
SLC transporter disorders 94 2.11e-01 -7.47e-02 5.08e-01
Dopamine Neurotransmitter Release Cycle 21 5.54e-01 7.46e-02 8.02e-01
Nef and signal transduction 8 7.15e-01 -7.46e-02 8.96e-01
Elevation of cytosolic Ca2+ levels 16 6.06e-01 7.45e-02 8.27e-01
G beta:gamma signalling through PLC beta 20 5.64e-01 7.45e-02 8.08e-01
Nervous system development 551 2.81e-03 -7.45e-02 2.41e-02
Protein methylation 15 6.18e-01 -7.44e-02 8.30e-01
Glycosphingolipid transport 8 7.16e-01 -7.43e-02 8.96e-01
Resolution of Abasic Sites (AP sites) 38 4.29e-01 -7.41e-02 7.25e-01
Developmental Biology 1194 1.68e-05 7.40e-02 4.74e-04
Assembly Of The HIV Virion 16 6.09e-01 -7.39e-02 8.27e-01
Molybdenum cofactor biosynthesis 6 7.54e-01 -7.38e-02 9.11e-01
Signaling by FGFR2 in disease 42 4.08e-01 7.37e-02 7.06e-01
Defective CHST6 causes MCDC1 8 7.18e-01 7.36e-02 8.96e-01
Base Excision Repair 68 2.94e-01 -7.36e-02 5.94e-01
Maturation of spike protein 9683686 5 7.76e-01 -7.36e-02 9.22e-01
CDC42 GTPase cycle 142 1.30e-01 7.36e-02 3.81e-01
Collagen biosynthesis and modifying enzymes 65 3.07e-01 7.32e-02 6.08e-01
Downstream signal transduction 29 4.96e-01 -7.31e-02 7.64e-01
Dectin-2 family 28 5.04e-01 -7.30e-02 7.68e-01
PKA activation 18 5.93e-01 7.28e-02 8.20e-01
Muscle contraction 196 7.90e-02 7.28e-02 2.78e-01
Transcriptional Regulation by E2F6 32 4.77e-01 -7.27e-02 7.61e-01
Semaphorin interactions 61 3.27e-01 -7.26e-02 6.29e-01
Respiratory syncytial virus (RSV) attachment and entry 21 5.65e-01 7.26e-02 8.08e-01
SUMO is proteolytically processed 6 7.60e-01 -7.22e-02 9.12e-01
Smooth Muscle Contraction 42 4.19e-01 7.21e-02 7.15e-01
RAB geranylgeranylation 57 3.48e-01 -7.19e-02 6.54e-01
TGF-beta receptor signaling activates SMADs 47 3.94e-01 -7.19e-02 6.95e-01
Integration of energy metabolism 105 2.03e-01 7.18e-02 4.95e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 4.44e-01 -7.18e-02 7.36e-01
Regulation of CDH19 Expression and Function 7 7.43e-01 -7.16e-02 9.09e-01
G beta:gamma signalling through CDC42 19 5.89e-01 7.16e-02 8.20e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 4.91e-01 -7.15e-02 7.63e-01
Nitric oxide stimulates guanylate cyclase 21 5.71e-01 7.15e-02 8.13e-01
RUNX3 regulates NOTCH signaling 13 6.56e-01 7.14e-02 8.56e-01
Platelet calcium homeostasis 27 5.21e-01 7.13e-02 7.78e-01
Striated Muscle Contraction 35 4.66e-01 7.12e-02 7.52e-01
Signaling by MET 78 2.78e-01 -7.11e-02 5.78e-01
Transcriptional regulation by RUNX2 117 1.85e-01 -7.10e-02 4.76e-01
Listeria monocytogenes entry into host cells 19 5.94e-01 -7.07e-02 8.20e-01
Advanced glycosylation endproduct receptor signaling 13 6.60e-01 -7.04e-02 8.59e-01
Budding and maturation of HIV virion 28 5.19e-01 -7.04e-02 7.76e-01
VEGFA-VEGFR2 Pathway 94 2.38e-01 -7.04e-02 5.44e-01
Other semaphorin interactions 18 6.07e-01 -7.00e-02 8.27e-01
Acyl chain remodelling of PG 18 6.07e-01 -7.00e-02 8.27e-01
Positive epigenetic regulation of rRNA expression 68 3.19e-01 -6.99e-02 6.21e-01
Role of LAT2/NTAL/LAB on calcium mobilization 16 6.30e-01 6.95e-02 8.40e-01
E2F mediated regulation of DNA replication 20 5.91e-01 -6.95e-02 8.20e-01
Metabolism of proteins 1899 5.50e-07 -6.95e-02 1.96e-05
Transcriptional Regulation by NPAS4 32 4.98e-01 6.92e-02 7.65e-01
Gain-of-function MRAS complexes activate RAF signaling 7 7.51e-01 -6.92e-02 9.10e-01
SHOC2 M1731 mutant abolishes MRAS complex function 7 7.51e-01 -6.92e-02 9.10e-01
Signaling by MRAS-complex mutants 7 7.51e-01 -6.92e-02 9.10e-01
Bacterial Infection Pathways 67 3.28e-01 -6.91e-02 6.31e-01
NOTCH2 intracellular domain regulates transcription 11 6.93e-01 6.89e-02 8.82e-01
FCGR activation 10 7.07e-01 -6.87e-02 8.91e-01
Generation of second messenger molecules 25 5.53e-01 6.86e-02 8.02e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 5.53e-01 -6.85e-02 8.02e-01
Pyruvate metabolism 29 5.24e-01 -6.83e-02 7.80e-01
Intra-Golgi traffic 43 4.39e-01 -6.82e-02 7.32e-01
EGFR downregulation 29 5.26e-01 6.81e-02 7.81e-01
Transport of RCbl within the body 8 7.39e-01 6.81e-02 9.05e-01
NOSTRIN mediated eNOS trafficking 5 7.92e-01 -6.80e-02 9.32e-01
G alpha (12/13) signalling events 74 3.12e-01 6.79e-02 6.15e-01
Thrombin signalling through proteinase activated receptors (PARs) 32 5.07e-01 -6.77e-02 7.69e-01
Defective pyroptosis 34 4.95e-01 -6.76e-02 7.64e-01
Termination of translesion DNA synthesis 32 5.09e-01 -6.74e-02 7.70e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 7.94e-01 6.73e-02 9.33e-01
Death Receptor Signaling 144 1.64e-01 -6.72e-02 4.41e-01
Transcription of the HIV genome 66 3.45e-01 -6.72e-02 6.53e-01
Apoptotic execution phase 49 4.19e-01 -6.67e-02 7.15e-01
NrCAM interactions 6 7.77e-01 -6.67e-02 9.23e-01
Reduction of cytosolic Ca++ levels 11 7.02e-01 6.65e-02 8.88e-01
Acetylcholine regulates insulin secretion 10 7.17e-01 6.63e-02 8.96e-01
L1CAM interactions 111 2.28e-01 -6.62e-02 5.29e-01
MET promotes cell motility 41 4.65e-01 -6.60e-02 7.52e-01
Digestion of dietary carbohydrate 6 7.80e-01 6.58e-02 9.23e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 5.49e-01 6.55e-02 7.98e-01
EPHA-mediated growth cone collapse 29 5.42e-01 6.54e-02 7.94e-01
Autophagy 142 1.79e-01 -6.54e-02 4.64e-01
Synthesis of diphthamide-EEF2 8 7.49e-01 -6.54e-02 9.10e-01
CD209 (DC-SIGN) signaling 20 6.13e-01 -6.53e-02 8.30e-01
Signaling by VEGF 102 2.55e-01 -6.52e-02 5.58e-01
Amino Acid conjugation 8 7.50e-01 6.51e-02 9.10e-01
Conjugation of carboxylic acids 8 7.50e-01 6.51e-02 9.10e-01
Activation of BH3-only proteins 30 5.37e-01 -6.51e-02 7.92e-01
Macroautophagy 128 2.04e-01 -6.50e-02 4.95e-01
Cytokine Signaling in Immune system 713 3.19e-03 -6.48e-02 2.68e-02
Regulation of RUNX1 Expression and Activity 25 5.75e-01 6.48e-02 8.15e-01
Constitutive Signaling by EGFRvIII 15 6.64e-01 6.47e-02 8.61e-01
Signaling by EGFRvIII in Cancer 15 6.64e-01 6.47e-02 8.61e-01
Phase 2 - plateau phase 14 6.75e-01 -6.46e-02 8.65e-01
ALK mutants bind TKIs 12 6.98e-01 -6.46e-02 8.86e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 17 6.47e-01 6.42e-02 8.53e-01
TP53 Regulates Metabolic Genes 83 3.13e-01 -6.41e-02 6.15e-01
Neddylation 233 9.28e-02 -6.39e-02 3.10e-01
Highly calcium permeable nicotinic acetylcholine receptors 9 7.40e-01 6.39e-02 9.06e-01
G-protein beta:gamma signalling 30 5.46e-01 6.37e-02 7.97e-01
Regulation of TP53 Activity 155 1.71e-01 -6.37e-02 4.52e-01
Hyaluronan metabolism 17 6.50e-01 -6.36e-02 8.53e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 21 6.14e-01 -6.36e-02 8.30e-01
Visual phototransduction 93 2.91e-01 6.34e-02 5.91e-01
Transport of connexons to the plasma membrane 19 6.32e-01 6.34e-02 8.42e-01
Regulation of NPAS4 gene transcription 5 8.06e-01 -6.33e-02 9.42e-01
Regulation of insulin secretion 77 3.38e-01 6.31e-02 6.44e-01
Aquaporin-mediated transport 51 4.37e-01 -6.28e-02 7.32e-01
Miro GTPase Cycle 8 7.58e-01 -6.28e-02 9.12e-01
Regulation of BACH1 activity 15 6.75e-01 6.26e-02 8.65e-01
Immune System 1894 6.63e-06 -6.26e-02 2.04e-04
Metabolic disorders of biological oxidation enzymes 32 5.41e-01 6.25e-02 7.93e-01
Signaling by NOTCH3 48 4.54e-01 6.25e-02 7.42e-01
Presynaptic function of Kainate receptors 21 6.21e-01 6.23e-02 8.32e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 6.67e-01 6.21e-02 8.63e-01
Deadenylation of mRNA 22 6.15e-01 -6.20e-02 8.30e-01
FLT3 signaling in disease 28 5.72e-01 -6.17e-02 8.14e-01
HDL remodeling 10 7.35e-01 6.17e-02 9.04e-01
Respiratory Syncytial Virus Infection Pathway 106 2.73e-01 -6.16e-02 5.76e-01
Glycosphingolipid catabolism 33 5.41e-01 -6.15e-02 7.93e-01
Complement cascade 54 4.35e-01 -6.14e-02 7.30e-01
Evasion by RSV of host interferon responses 27 5.81e-01 -6.13e-02 8.17e-01
Organic anion transporters 10 7.37e-01 6.12e-02 9.04e-01
Pyrimidine catabolism 12 7.14e-01 -6.12e-02 8.96e-01
Disease 1689 3.00e-05 -6.11e-02 7.80e-04
Synthesis of IP2, IP, and Ins in the cytosol 13 7.03e-01 -6.10e-02 8.88e-01
Gap junction trafficking 46 4.75e-01 6.09e-02 7.61e-01
Glycerophospholipid catabolism 7 7.81e-01 6.08e-02 9.23e-01
G beta:gamma signalling through BTK 17 6.65e-01 6.07e-02 8.61e-01
Azathioprine ADME 19 6.48e-01 -6.06e-02 8.53e-01
CDC6 association with the ORC:origin complex 8 7.67e-01 6.05e-02 9.16e-01
IKK complex recruitment mediated by RIP1 22 6.24e-01 -6.04e-02 8.34e-01
RNA Polymerase I Transcription Initiation 45 4.84e-01 6.03e-02 7.62e-01
Processing of SMDT1 14 6.97e-01 -6.02e-02 8.85e-01
Antimicrobial peptides 73 3.75e-01 -6.01e-02 6.81e-01
MET activates PI3K/AKT signaling 6 7.99e-01 6.00e-02 9.37e-01
PI3K/AKT Signaling in Cancer 102 2.95e-01 6.00e-02 5.96e-01
MAPK family signaling cascades 310 7.02e-02 -5.98e-02 2.56e-01
Synthesis of PA 37 5.30e-01 5.96e-02 7.85e-01
Phase 3 - rapid repolarisation 8 7.71e-01 5.96e-02 9.18e-01
RHOG GTPase cycle 71 3.87e-01 5.94e-02 6.89e-01
Antigen processing: Ubiquitination & Proteasome degradation 295 8.14e-02 -5.90e-02 2.84e-01
Cell-Cell communication 148 2.16e-01 5.89e-02 5.15e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 101 3.07e-01 5.89e-02 6.07e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 7.88e-01 -5.88e-02 9.29e-01
Glucagon signaling in metabolic regulation 32 5.65e-01 5.88e-02 8.08e-01
Vitamin D (calciferol) metabolism 12 7.25e-01 5.88e-02 9.01e-01
Synthesis of PIPs at the late endosome membrane 10 7.48e-01 -5.86e-02 9.10e-01
Negative epigenetic regulation of rRNA expression 70 3.99e-01 -5.82e-02 7.00e-01
rRNA processing in the mitochondrion 9 7.62e-01 -5.82e-02 9.14e-01
NoRC negatively regulates rRNA expression 68 4.08e-01 -5.80e-02 7.06e-01
Plasma lipoprotein clearance 37 5.43e-01 5.78e-02 7.94e-01
Signaling by NODAL 20 6.55e-01 -5.76e-02 8.56e-01
Signaling by Nuclear Receptors 259 1.11e-01 5.75e-02 3.46e-01
Golgi Associated Vesicle Biogenesis 51 4.77e-01 -5.75e-02 7.61e-01
Inositol phosphate metabolism 45 5.07e-01 -5.72e-02 7.69e-01
Alpha-defensins 8 7.81e-01 -5.68e-02 9.23e-01
RMTs methylate histone arginines 43 5.19e-01 5.68e-02 7.76e-01
Mitochondrial RNA degradation 10 7.56e-01 5.67e-02 9.11e-01
Gap junction trafficking and regulation 48 4.97e-01 5.66e-02 7.65e-01
PKMTs methylate histone lysines 42 5.26e-01 5.66e-02 7.81e-01
PCP/CE pathway 91 3.52e-01 -5.65e-02 6.59e-01
SIRT1 negatively regulates rRNA expression 30 5.94e-01 -5.63e-02 8.20e-01
RORA activates gene expression 17 6.88e-01 5.62e-02 8.77e-01
NF-kB is activated and signals survival 12 7.36e-01 -5.61e-02 9.04e-01
Activated NTRK2 signals through CDK5 6 8.12e-01 5.61e-02 9.44e-01
Mitochondrial iron-sulfur cluster biogenesis 13 7.27e-01 -5.60e-02 9.02e-01
Formation of the beta-catenin:TCF transactivating complex 55 4.75e-01 5.56e-02 7.61e-01
Sulfur amino acid metabolism 27 6.18e-01 5.55e-02 8.30e-01
Cargo recognition for clathrin-mediated endocytosis 99 3.41e-01 5.54e-02 6.46e-01
Signaling by LRP5 mutants 6 8.15e-01 5.53e-02 9.46e-01
Bile acid and bile salt metabolism 45 5.21e-01 -5.53e-02 7.78e-01
Metabolism 2001 5.01e-05 -5.49e-02 1.18e-03
Regulation of TP53 Expression and Degradation 37 5.64e-01 -5.49e-02 8.08e-01
FGFR2 mutant receptor activation 32 5.92e-01 5.48e-02 8.20e-01
Ion homeostasis 52 4.95e-01 -5.47e-02 7.64e-01
SLBP independent Processing of Histone Pre-mRNAs 10 7.65e-01 -5.45e-02 9.16e-01
Signal Transduction 2466 1.01e-05 5.45e-02 3.01e-04
Interferon gamma signaling 86 3.83e-01 5.45e-02 6.85e-01
Metabolism of water-soluble vitamins and cofactors 125 2.95e-01 -5.42e-02 5.96e-01
Interaction With Cumulus Cells And The Zona Pellucida 11 7.56e-01 -5.41e-02 9.11e-01
Epigenetic regulation of gene expression 144 2.62e-01 -5.41e-02 5.65e-01
Defective CHST3 causes SEDCJD 7 8.04e-01 -5.40e-02 9.41e-01
Modulation by Mtb of host immune system 6 8.19e-01 -5.39e-02 9.47e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 18 6.93e-01 -5.38e-02 8.82e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 59 4.75e-01 5.37e-02 7.61e-01
Class I MHC mediated antigen processing & presentation 359 8.23e-02 -5.34e-02 2.87e-01
FCERI mediated MAPK activation 32 6.01e-01 5.34e-02 8.26e-01
Basigin interactions 24 6.51e-01 5.34e-02 8.53e-01
RHOU GTPase cycle 37 5.75e-01 -5.33e-02 8.15e-01
RHOB GTPase cycle 66 4.54e-01 5.33e-02 7.42e-01
Fatty acyl-CoA biosynthesis 37 5.78e-01 5.28e-02 8.15e-01
Paracetamol ADME 26 6.41e-01 5.28e-02 8.50e-01
Signaling by EGFR in Cancer 24 6.54e-01 5.28e-02 8.55e-01
Regulation of TP53 Degradation 36 5.87e-01 -5.23e-02 8.20e-01
Synthesis of PIPs at the plasma membrane 48 5.32e-01 -5.22e-02 7.87e-01
Signaling by Rho GTPases 627 2.64e-02 -5.19e-02 1.30e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 7.55e-01 5.19e-02 9.11e-01
Chromatin modifying enzymes 216 1.88e-01 -5.19e-02 4.78e-01
Chromatin organization 216 1.88e-01 -5.19e-02 4.78e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 119 3.29e-01 -5.19e-02 6.31e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 8.41e-01 -5.17e-02 9.53e-01
Chylomicron clearance 5 8.41e-01 5.17e-02 9.53e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 6.36e-01 5.17e-02 8.45e-01
Meiotic synapsis 54 5.12e-01 -5.15e-02 7.71e-01
Netrin-1 signaling 48 5.37e-01 5.15e-02 7.92e-01
Signaling by Hedgehog 147 2.81e-01 -5.15e-02 5.82e-01
HDACs deacetylate histones 54 5.13e-01 -5.15e-02 7.71e-01
Diseases of carbohydrate metabolism 31 6.20e-01 -5.14e-02 8.31e-01
Formation of the Early Elongation Complex 32 6.15e-01 -5.14e-02 8.30e-01
Formation of the HIV-1 Early Elongation Complex 32 6.15e-01 -5.14e-02 8.30e-01
MET activates PTPN11 5 8.44e-01 5.08e-02 9.53e-01
LDL remodeling 6 8.29e-01 5.08e-02 9.53e-01
Signaling by NTRK1 (TRKA) 113 3.51e-01 -5.08e-02 6.59e-01
PKA activation in glucagon signalling 17 7.18e-01 5.05e-02 8.96e-01
Adaptive Immune System 721 2.09e-02 -5.05e-02 1.12e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 7.27e-01 -5.05e-02 9.02e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 7.44e-01 -5.05e-02 9.09e-01
Neurofascin interactions 6 8.32e-01 5.01e-02 9.53e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 7.55e-01 5.01e-02 9.11e-01
Tie2 Signaling 18 7.13e-01 -5.00e-02 8.96e-01
RNA Polymerase I Promoter Opening 26 6.59e-01 -5.00e-02 8.59e-01
A tetrasaccharide linker sequence is required for GAG synthesis 23 6.78e-01 4.99e-02 8.69e-01
HSF1-dependent transactivation 34 6.16e-01 4.97e-02 8.30e-01
OAS antiviral response 8 8.09e-01 -4.94e-02 9.42e-01
Regulation of localization of FOXO transcription factors 11 7.78e-01 4.92e-02 9.23e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 7.78e-01 -4.91e-02 9.23e-01
Generic Transcription Pathway 1181 4.69e-03 4.89e-02 3.46e-02
Signaling by cytosolic FGFR1 fusion mutants 18 7.20e-01 -4.88e-02 8.96e-01
Lysine catabolism 12 7.70e-01 -4.88e-02 9.18e-01
Interleukin-36 pathway 7 8.23e-01 -4.87e-02 9.50e-01
MET Receptor Activation 6 8.37e-01 4.85e-02 9.53e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 641 3.63e-02 -4.85e-02 1.64e-01
Maturation of nucleoprotein 9683610 11 7.81e-01 4.84e-02 9.23e-01
BBSome-mediated cargo-targeting to cilium 23 6.88e-01 -4.84e-02 8.77e-01
Zinc transporters 15 7.46e-01 -4.83e-02 9.10e-01
Activated NTRK3 signals through PI3K 6 8.39e-01 4.79e-02 9.53e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.56e-01 -4.79e-02 9.11e-01
Diseases of signal transduction by growth factor receptors and second messengers 442 8.49e-02 -4.78e-02 2.91e-01
Transport of vitamins, nucleosides, and related molecules 38 6.10e-01 4.78e-02 8.29e-01
Signaling by NTRK3 (TRKC) 17 7.35e-01 4.75e-02 9.04e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 8.41e-01 4.74e-02 9.53e-01
Replacement of protamines by nucleosomes in the male pronucleus 22 7.00e-01 -4.74e-02 8.87e-01
Cytosolic sulfonation of small molecules 22 7.02e-01 4.71e-02 8.88e-01
Interferon Signaling 246 2.04e-01 -4.70e-02 4.95e-01
Defensins 32 6.46e-01 4.69e-02 8.53e-01
Vesicle-mediated transport 641 4.46e-02 -4.65e-02 1.87e-01
Platelet degranulation 115 3.93e-01 -4.61e-02 6.95e-01
Zinc influx into cells by the SLC39 gene family 10 8.01e-01 4.61e-02 9.38e-01
Signaling by FGFR1 in disease 38 6.25e-01 4.59e-02 8.34e-01
Negative regulation of FLT3 15 7.61e-01 -4.54e-02 9.12e-01
Estrogen-stimulated signaling through PRKCZ 6 8.48e-01 4.53e-02 9.53e-01
Regulated proteolysis of p75NTR 11 7.95e-01 -4.53e-02 9.33e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 54 5.66e-01 -4.52e-02 8.08e-01
Signaling by ERBB2 50 5.81e-01 4.51e-02 8.17e-01
G beta:gamma signalling through PI3Kgamma 25 6.97e-01 4.50e-02 8.85e-01
RND2 GTPase cycle 41 6.19e-01 4.49e-02 8.30e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 8.06e-01 4.49e-02 9.41e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 6.15e-01 4.49e-02 8.30e-01
Oxidative Stress Induced Senescence 88 4.68e-01 -4.48e-02 7.54e-01
Diseases of Base Excision Repair 5 8.62e-01 -4.48e-02 9.60e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 8.17e-01 -4.45e-02 9.47e-01
Keratan sulfate degradation 15 7.66e-01 4.43e-02 9.16e-01
MET receptor recycling 10 8.09e-01 4.41e-02 9.42e-01
Membrane Trafficking 603 6.47e-02 -4.41e-02 2.43e-01
Insulin processing 24 7.10e-01 4.38e-02 8.94e-01
NPAS4 regulates expression of target genes 20 7.35e-01 4.37e-02 9.04e-01
Transferrin endocytosis and recycling 29 6.84e-01 4.37e-02 8.74e-01
RAS signaling downstream of NF1 loss-of-function variants 7 8.42e-01 -4.36e-02 9.53e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 6.80e-01 4.35e-02 8.70e-01
Toll-like Receptor Cascades 158 3.46e-01 -4.34e-02 6.53e-01
Regulation of Complement cascade 43 6.24e-01 -4.32e-02 8.34e-01
Activation of NOXA and translocation to mitochondria 5 8.67e-01 4.31e-02 9.63e-01
STING mediated induction of host immune responses 16 7.68e-01 -4.27e-02 9.16e-01
Signal amplification 33 6.72e-01 -4.27e-02 8.64e-01
Defects in biotin (Btn) metabolism 8 8.36e-01 4.22e-02 9.53e-01
Pre-NOTCH Processing in Golgi 18 7.57e-01 4.21e-02 9.12e-01
Kinesins 59 5.79e-01 -4.18e-02 8.16e-01
TRAF6 mediated IRF7 activation 22 7.35e-01 -4.17e-02 9.04e-01
FCERI mediated Ca+2 mobilization 30 6.95e-01 4.14e-02 8.84e-01
Nuclear Receptor transcription pathway 51 6.11e-01 4.12e-02 8.29e-01
Glycerophospholipid biosynthesis 122 4.32e-01 -4.12e-02 7.27e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 7.51e-01 -4.09e-02 9.10e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 6.99e-01 4.08e-02 8.86e-01
Sphingolipid de novo biosynthesis 37 6.69e-01 -4.06e-02 8.64e-01
Activation of Ca-permeable Kainate Receptor 9 8.33e-01 -4.06e-02 9.53e-01
Ionotropic activity of kainate receptors 9 8.33e-01 -4.06e-02 9.53e-01
FOXO-mediated transcription of cell cycle genes 16 7.79e-01 -4.05e-02 9.23e-01
Potential therapeutics for SARS 92 5.04e-01 -4.03e-02 7.68e-01
Interleukin-1 processing 9 8.34e-01 4.02e-02 9.53e-01
HIV Transcription Initiation 43 6.51e-01 -3.99e-02 8.53e-01
RNA Polymerase II HIV Promoter Escape 43 6.51e-01 -3.99e-02 8.53e-01
RNA Polymerase II Promoter Escape 43 6.51e-01 -3.99e-02 8.53e-01
RNA Polymerase II Transcription Initiation 43 6.51e-01 -3.99e-02 8.53e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 6.51e-01 -3.99e-02 8.53e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 6.51e-01 -3.99e-02 8.53e-01
tRNA modification in the mitochondrion 8 8.46e-01 -3.98e-02 9.53e-01
Chylomicron remodeling 10 8.28e-01 3.97e-02 9.53e-01
Response to elevated platelet cytosolic Ca2+ 120 4.55e-01 -3.94e-02 7.42e-01
Diseases associated with glycosylation precursor biosynthesis 15 7.92e-01 -3.94e-02 9.32e-01
Signaling by WNT 288 2.50e-01 3.94e-02 5.55e-01
PKA-mediated phosphorylation of CREB 19 7.67e-01 3.93e-02 9.16e-01
Activation of HOX genes during differentiation 83 5.39e-01 3.90e-02 7.92e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 83 5.39e-01 3.90e-02 7.92e-01
NCAM signaling for neurite out-growth 62 5.97e-01 3.88e-02 8.22e-01
Activation of kainate receptors upon glutamate binding 29 7.18e-01 3.88e-02 8.96e-01
RND3 GTPase cycle 41 6.68e-01 3.88e-02 8.63e-01
RNA Polymerase I Transcription Termination 29 7.19e-01 3.86e-02 8.96e-01
Ca2+ activated K+ channels 9 8.42e-01 -3.84e-02 9.53e-01
Regulation of FOXO transcriptional activity by acetylation 9 8.42e-01 3.83e-02 9.53e-01
Noncanonical activation of NOTCH3 8 8.52e-01 -3.81e-02 9.56e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 18 7.80e-01 3.81e-02 9.23e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 7.37e-01 3.81e-02 9.04e-01
FLT3 signaling through SRC family kinases 6 8.72e-01 -3.79e-02 9.63e-01
Metal ion SLC transporters 23 7.53e-01 -3.79e-02 9.11e-01
Leishmania infection 155 4.16e-01 -3.78e-02 7.13e-01
Parasitic Infection Pathways 155 4.16e-01 -3.78e-02 7.13e-01
Beta-oxidation of very long chain fatty acids 10 8.37e-01 -3.77e-02 9.53e-01
Small interfering RNA (siRNA) biogenesis 9 8.45e-01 3.77e-02 9.53e-01
ADP signalling through P2Y purinoceptor 1 25 7.45e-01 -3.76e-02 9.10e-01
CD163 mediating an anti-inflammatory response 9 8.45e-01 -3.75e-02 9.53e-01
Adenylate cyclase inhibitory pathway 14 8.08e-01 3.75e-02 9.42e-01
Keratan sulfate/keratin metabolism 36 6.98e-01 3.73e-02 8.86e-01
Pyrimidine salvage 10 8.39e-01 -3.72e-02 9.53e-01
Post-translational protein modification 1341 2.28e-02 -3.71e-02 1.18e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 8.77e-01 -3.66e-02 9.63e-01
TGFBR1 KD Mutants in Cancer 6 8.77e-01 -3.66e-02 9.63e-01
Opioid Signalling 89 5.52e-01 -3.64e-02 8.02e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 15 8.07e-01 3.64e-02 9.42e-01
PTK6 Regulates Proteins Involved in RNA Processing 5 8.89e-01 3.62e-02 9.67e-01
Sperm Motility And Taxes 9 8.52e-01 -3.58e-02 9.56e-01
Regulation of MECP2 expression and activity 30 7.35e-01 3.57e-02 9.04e-01
Phase I - Functionalization of compounds 100 5.41e-01 -3.54e-02 7.93e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 38 7.07e-01 -3.52e-02 8.91e-01
Metabolism of steroids 149 4.59e-01 -3.52e-02 7.44e-01
p75NTR recruits signalling complexes 12 8.33e-01 -3.51e-02 9.53e-01
IRF3-mediated induction of type I IFN 13 8.27e-01 -3.50e-02 9.53e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 8.08e-01 -3.50e-02 9.42e-01
STAT5 activation downstream of FLT3 ITD mutants 10 8.48e-01 -3.49e-02 9.54e-01
Integrin cell surface interactions 83 5.83e-01 3.48e-02 8.18e-01
Assembly of the ORC complex at the origin of replication 32 7.33e-01 -3.48e-02 9.04e-01
GP1b-IX-V activation signalling 11 8.42e-01 3.48e-02 9.53e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 8.94e-01 3.44e-02 9.67e-01
Interleukin-4 and Interleukin-13 signaling 103 5.46e-01 -3.44e-02 7.97e-01
SUMOylation 170 4.40e-01 -3.43e-02 7.32e-01
Signaling by Non-Receptor Tyrosine Kinases 54 6.64e-01 -3.41e-02 8.61e-01
Signaling by PTK6 54 6.64e-01 -3.41e-02 8.61e-01
Synthesis of bile acids and bile salts 34 7.31e-01 -3.40e-02 9.04e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 8.26e-01 -3.39e-02 9.53e-01
cGMP effects 16 8.15e-01 3.38e-02 9.46e-01
Signaling by FGFR2 72 6.20e-01 -3.38e-02 8.31e-01
Sphingolipid catabolism 12 8.40e-01 -3.37e-02 9.53e-01
DAG and IP3 signaling 40 7.12e-01 3.37e-02 8.96e-01
Killing mechanisms 11 8.47e-01 3.35e-02 9.53e-01
WNT5:FZD7-mediated leishmania damping 11 8.47e-01 3.35e-02 9.53e-01
Free fatty acids regulate insulin secretion 10 8.55e-01 3.34e-02 9.56e-01
Histidine catabolism 8 8.71e-01 -3.31e-02 9.63e-01
RND1 GTPase cycle 41 7.14e-01 3.31e-02 8.96e-01
Signaling by NOTCH1 69 6.35e-01 3.30e-02 8.44e-01
Xenobiotics 22 7.89e-01 3.30e-02 9.30e-01
Keratan sulfate biosynthesis 28 7.63e-01 3.29e-02 9.14e-01
Phosphate bond hydrolysis by NTPDase proteins 8 8.73e-01 -3.28e-02 9.63e-01
PTEN Regulation 150 4.90e-01 -3.27e-02 7.63e-01
Regulation of NFE2L2 gene expression 8 8.73e-01 3.26e-02 9.63e-01
Synthesis of substrates in N-glycan biosythesis 62 6.59e-01 -3.24e-02 8.59e-01
CD28 dependent Vav1 pathway 11 8.53e-01 3.22e-02 9.56e-01
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 7 8.83e-01 3.21e-02 9.65e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 7.82e-01 -3.20e-02 9.23e-01
G2 Phase 5 9.01e-01 -3.20e-02 9.72e-01
RAC1 GTPase cycle 171 4.74e-01 3.17e-02 7.61e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 8.93e-01 -3.16e-02 9.67e-01
MTOR signalling 40 7.31e-01 -3.14e-02 9.04e-01
Synthesis of PI 5 9.04e-01 -3.10e-02 9.73e-01
Glutathione synthesis and recycling 12 8.54e-01 -3.06e-02 9.56e-01
HDL assembly 8 8.82e-01 3.03e-02 9.65e-01
Chaperone Mediated Autophagy 20 8.15e-01 -3.03e-02 9.46e-01
Phospholipid metabolism 199 4.63e-01 -3.02e-02 7.50e-01
Purine catabolism 17 8.32e-01 2.97e-02 9.53e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 8 8.85e-01 -2.95e-02 9.66e-01
RHOV GTPase cycle 36 7.61e-01 2.93e-02 9.12e-01
RHOC GTPase cycle 70 6.72e-01 -2.92e-02 8.65e-01
FLT3 Signaling 38 7.57e-01 -2.90e-02 9.12e-01
Nucleotide catabolism 35 7.67e-01 -2.89e-02 9.16e-01
Metabolism of lipids 723 1.86e-01 -2.89e-02 4.78e-01
Post-chaperonin tubulin folding pathway 22 8.17e-01 -2.85e-02 9.47e-01
PECAM1 interactions 12 8.66e-01 -2.82e-02 9.62e-01
Platelet activation, signaling and aggregation 247 4.45e-01 -2.82e-02 7.38e-01
Glutamate Neurotransmitter Release Cycle 24 8.11e-01 2.82e-02 9.44e-01
Amino acid transport across the plasma membrane 30 7.91e-01 2.80e-02 9.31e-01
Effects of PIP2 hydrolysis 26 8.05e-01 -2.79e-02 9.41e-01
Miscellaneous substrates 12 8.68e-01 -2.78e-02 9.63e-01
FGFR2b ligand binding and activation 10 8.80e-01 2.77e-02 9.64e-01
COPI-independent Golgi-to-ER retrograde traffic 51 7.33e-01 -2.76e-02 9.04e-01
Phase 1 - inactivation of fast Na+ channels 6 9.07e-01 2.76e-02 9.73e-01
RAC3 GTPase cycle 85 6.63e-01 2.74e-02 8.61e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 8.70e-01 -2.73e-02 9.63e-01
Phase 0 - rapid depolarisation 31 7.93e-01 -2.72e-02 9.32e-01
Acetylcholine binding and downstream events 14 8.60e-01 2.72e-02 9.58e-01
Postsynaptic nicotinic acetylcholine receptors 14 8.60e-01 2.72e-02 9.58e-01
Regulation of IFNG signaling 14 8.61e-01 2.71e-02 9.58e-01
VLDLR internalisation and degradation 16 8.51e-01 2.71e-02 9.55e-01
Signaling by PDGFRA extracellular domain mutants 12 8.72e-01 2.69e-02 9.63e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 8.72e-01 2.69e-02 9.63e-01
PD-1 signaling 17 8.48e-01 2.69e-02 9.53e-01
Lysosome Vesicle Biogenesis 33 7.89e-01 -2.69e-02 9.30e-01
Presynaptic depolarization and calcium channel opening 12 8.72e-01 -2.68e-02 9.63e-01
RHOA GTPase cycle 139 5.89e-01 2.65e-02 8.20e-01
Metalloprotease DUBs 27 8.12e-01 -2.64e-02 9.44e-01
Regulation of TP53 Activity through Methylation 19 8.42e-01 -2.63e-02 9.53e-01
Signaling by NTRKs 132 6.01e-01 -2.63e-02 8.26e-01
NFE2L2 regulates pentose phosphate pathway genes 7 9.04e-01 2.63e-02 9.73e-01
Cell surface interactions at the vascular wall 123 6.16e-01 -2.62e-02 8.30e-01
Regulation of PTEN gene transcription 59 7.28e-01 -2.61e-02 9.02e-01
Syndecan interactions 26 8.18e-01 2.61e-02 9.47e-01
Glycogen metabolism 22 8.32e-01 2.61e-02 9.53e-01
APOBEC3G mediated resistance to HIV-1 infection 5 9.20e-01 2.60e-02 9.78e-01
Diseases of glycosylation 139 5.97e-01 2.60e-02 8.22e-01
Dermatan sulfate biosynthesis 10 8.87e-01 2.60e-02 9.67e-01
Stimuli-sensing channels 101 6.53e-01 2.59e-02 8.54e-01
IRAK2 mediated activation of TAK1 complex 9 8.93e-01 -2.58e-02 9.67e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 9.21e-01 2.56e-02 9.79e-01
Signaling by FGFR in disease 62 7.29e-01 2.55e-02 9.02e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 8.75e-01 -2.53e-02 9.63e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 8.57e-01 -2.53e-02 9.57e-01
SUMO E3 ligases SUMOylate target proteins 164 5.82e-01 -2.49e-02 8.18e-01
RNA Polymerase II Transcription 1299 1.34e-01 2.48e-02 3.86e-01
SLC-mediated transmembrane transport 237 5.13e-01 2.47e-02 7.71e-01
Sphingolipid metabolism 101 6.70e-01 -2.46e-02 8.64e-01
Signaling by Receptor Tyrosine Kinases 510 3.46e-01 2.44e-02 6.53e-01
Cell death signalling via NRAGE, NRIF and NADE 69 7.30e-01 2.40e-02 9.04e-01
Aggrephagy 40 7.94e-01 2.39e-02 9.32e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 29 8.26e-01 -2.36e-02 9.52e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 8.93e-01 -2.35e-02 9.67e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 8.75e-01 2.34e-02 9.63e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 8.75e-01 2.34e-02 9.63e-01
The phototransduction cascade 32 8.19e-01 -2.33e-02 9.47e-01
Synthesis of PC 27 8.34e-01 -2.33e-02 9.53e-01
Growth hormone receptor signaling 22 8.50e-01 2.32e-02 9.55e-01
Plasma lipoprotein assembly, remodeling, and clearance 74 7.31e-01 2.31e-02 9.04e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 9.29e-01 2.29e-02 9.80e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 9.29e-01 2.29e-02 9.80e-01
Signaling by FLT3 fusion proteins 19 8.63e-01 -2.29e-02 9.60e-01
Multifunctional anion exchangers 9 9.06e-01 2.28e-02 9.73e-01
Regulation of lipid metabolism by PPARalpha 115 6.74e-01 -2.27e-02 8.65e-01
Ion transport by P-type ATPases 51 7.81e-01 -2.25e-02 9.23e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 8.01e-01 2.19e-02 9.39e-01
Prostanoid ligand receptors 9 9.09e-01 -2.19e-02 9.74e-01
Signaling by FLT3 ITD and TKD mutants 16 8.81e-01 -2.17e-02 9.65e-01
RNA Polymerase I Promoter Escape 53 7.86e-01 -2.15e-02 9.28e-01
Alpha-protein kinase 1 signaling pathway 10 9.09e-01 -2.10e-02 9.74e-01
Metabolism of steroid hormones 34 8.33e-01 2.09e-02 9.53e-01
Synthesis of Dolichyl-phosphate 6 9.30e-01 -2.07e-02 9.80e-01
Translation of Structural Proteins 9683701 29 8.47e-01 -2.07e-02 9.53e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 9.10e-01 2.06e-02 9.74e-01
Late SARS-CoV-2 Infection Events 67 7.71e-01 2.06e-02 9.18e-01
Unwinding of DNA 12 9.03e-01 -2.04e-02 9.73e-01
Signaling by PDGFR in disease 20 8.76e-01 2.02e-02 9.63e-01
Ovarian tumor domain proteases 36 8.34e-01 -2.02e-02 9.53e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 8.79e-01 2.01e-02 9.64e-01
Biological oxidations 202 6.24e-01 -2.00e-02 8.34e-01
Platelet homeostasis 84 7.56e-01 1.96e-02 9.11e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 8.99e-01 -1.95e-02 9.71e-01
Anti-inflammatory response favouring Leishmania parasite infection 73 7.73e-01 -1.95e-02 9.20e-01
Leishmania parasite growth and survival 73 7.73e-01 -1.95e-02 9.20e-01
Beta-oxidation of pristanoyl-CoA 9 9.20e-01 -1.94e-02 9.78e-01
Interleukin-6 family signaling 24 8.69e-01 1.94e-02 9.63e-01
RSV-host interactions 84 7.59e-01 -1.94e-02 9.12e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 9.40e-01 -1.94e-02 9.84e-01
Clathrin-mediated endocytosis 138 7.00e-01 1.90e-02 8.87e-01
NGF-stimulated transcription 38 8.40e-01 1.89e-02 9.53e-01
ADP signalling through P2Y purinoceptor 12 22 8.79e-01 1.87e-02 9.64e-01
ESR-mediated signaling 182 6.67e-01 1.85e-02 8.63e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 9.12e-01 -1.84e-02 9.75e-01
Activation of NMDA receptors and postsynaptic events 86 7.69e-01 1.83e-02 9.17e-01
PTK6 Regulates Cell Cycle 6 9.38e-01 1.83e-02 9.83e-01
Metabolism of carbohydrates 283 5.98e-01 -1.82e-02 8.23e-01
Signaling by NOTCH 205 6.58e-01 -1.80e-02 8.58e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 9.18e-01 1.80e-02 9.78e-01
MET activates PTK2 signaling 30 8.66e-01 -1.78e-02 9.63e-01
Ca-dependent events 36 8.54e-01 -1.77e-02 9.56e-01
RUNX2 regulates bone development 29 8.70e-01 -1.76e-02 9.63e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 8.83e-01 -1.74e-02 9.65e-01
Heme signaling 45 8.44e-01 -1.69e-02 9.53e-01
G-protein mediated events 53 8.32e-01 -1.68e-02 9.53e-01
Signaling by TGFB family members 121 7.52e-01 -1.67e-02 9.10e-01
Activation of AMPK downstream of NMDARs 27 8.81e-01 -1.66e-02 9.65e-01
Signaling by EGFR 51 8.38e-01 1.65e-02 9.53e-01
Conjugation of benzoate with glycine 6 9.44e-01 1.65e-02 9.84e-01
FOXO-mediated transcription 65 8.19e-01 -1.64e-02 9.47e-01
TRAIL signaling 8 9.36e-01 1.64e-02 9.83e-01
PI Metabolism 78 8.04e-01 -1.63e-02 9.41e-01
GRB7 events in ERBB2 signaling 5 9.50e-01 -1.62e-02 9.85e-01
Synthesis of PIPs at the early endosome membrane 15 9.14e-01 -1.61e-02 9.76e-01
Signaling by Hippo 19 9.04e-01 1.61e-02 9.73e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 8.97e-01 1.60e-02 9.69e-01
RHOH GTPase cycle 36 8.69e-01 1.59e-02 9.63e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 14 9.18e-01 -1.59e-02 9.78e-01
Cell recruitment (pro-inflammatory response) 26 8.89e-01 -1.59e-02 9.67e-01
Purinergic signaling in leishmaniasis infection 26 8.89e-01 -1.59e-02 9.67e-01
TNFs bind their physiological receptors 25 8.91e-01 1.59e-02 9.67e-01
Iron uptake and transport 56 8.39e-01 -1.57e-02 9.53e-01
GPVI-mediated activation cascade 34 8.74e-01 -1.57e-02 9.63e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 19 9.06e-01 1.57e-02 9.73e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 27 8.89e-01 1.55e-02 9.67e-01
Platelet Aggregation (Plug Formation) 39 8.70e-01 -1.52e-02 9.63e-01
Late endosomal microautophagy 33 8.84e-01 -1.47e-02 9.65e-01
Defective CHSY1 causes TPBS 7 9.47e-01 -1.46e-02 9.84e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 9.07e-01 -1.44e-02 9.73e-01
FGFR1 mutant receptor activation 31 8.90e-01 1.44e-02 9.67e-01
Inactivation, recovery and regulation of the phototransduction cascade 31 8.90e-01 -1.43e-02 9.67e-01
Triglyceride metabolism 34 8.86e-01 1.42e-02 9.67e-01
Costimulation by the CD28 family 61 8.49e-01 -1.41e-02 9.54e-01
p75 NTR receptor-mediated signalling 90 8.19e-01 -1.39e-02 9.47e-01
LGI-ADAM interactions 14 9.29e-01 1.38e-02 9.80e-01
PI3K/AKT activation 9 9.43e-01 1.38e-02 9.84e-01
Uptake and actions of bacterial toxins 28 8.99e-01 -1.38e-02 9.71e-01
Maturation of spike protein 9694548 35 8.88e-01 1.38e-02 9.67e-01
Defective ST3GAL3 causes MCT12 and EIEE15 8 9.46e-01 -1.37e-02 9.84e-01
Nephrin family interactions 21 9.14e-01 1.36e-02 9.76e-01
Other interleukin signaling 24 9.09e-01 -1.35e-02 9.74e-01
CD28 co-stimulation 32 8.95e-01 -1.34e-02 9.68e-01
Synthesis of UDP-N-acetyl-glucosamine 7 9.51e-01 1.34e-02 9.85e-01
Metabolism of vitamins and cofactors 188 7.51e-01 -1.34e-02 9.10e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.39e-01 1.33e-02 9.83e-01
ROBO receptors bind AKAP5 9 9.46e-01 1.30e-02 9.84e-01
RUNX2 regulates osteoblast differentiation 22 9.17e-01 -1.29e-02 9.78e-01
TCF dependent signaling in response to WNT 192 7.60e-01 1.28e-02 9.12e-01
PLC beta mediated events 48 8.78e-01 -1.28e-02 9.64e-01
Signaling by KIT in disease 20 9.22e-01 -1.26e-02 9.79e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 9.22e-01 -1.26e-02 9.79e-01
NFE2L2 regulating MDR associated enzymes 8 9.51e-01 1.25e-02 9.85e-01
Transport of small molecules 704 5.73e-01 -1.25e-02 8.15e-01
E2F-enabled inhibition of pre-replication complex formation 9 9.49e-01 -1.24e-02 9.84e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 9.30e-01 1.23e-02 9.80e-01
MHC class II antigen presentation 117 8.21e-01 1.21e-02 9.48e-01
Nucleotide-like (purinergic) receptors 13 9.40e-01 1.20e-02 9.84e-01
Ethanol oxidation 12 9.43e-01 1.18e-02 9.84e-01
Scavenging by Class A Receptors 19 9.29e-01 1.18e-02 9.80e-01
Signaling by Activin 17 9.34e-01 -1.17e-02 9.83e-01
RAC2 GTPase cycle 81 8.56e-01 1.16e-02 9.57e-01
Transport of bile salts and organic acids, metal ions and amine compounds 82 8.58e-01 1.14e-02 9.58e-01
PPARA activates gene expression 113 8.35e-01 -1.14e-02 9.53e-01
Myoclonic epilepsy of Lafora 9 9.53e-01 -1.12e-02 9.86e-01
FCGR3A-mediated IL10 synthesis 35 9.10e-01 1.11e-02 9.74e-01
Glycosphingolipid metabolism 52 8.92e-01 -1.09e-02 9.67e-01
Sialic acid metabolism 33 9.16e-01 1.07e-02 9.77e-01
Signaling by ALK 27 9.24e-01 -1.06e-02 9.80e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 9.37e-01 1.04e-02 9.83e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 9.37e-01 1.04e-02 9.83e-01
GAB1 signalosome 16 9.44e-01 1.01e-02 9.84e-01
P2Y receptors 9 9.60e-01 9.57e-03 9.89e-01
Diseases associated with glycosaminoglycan metabolism 38 9.19e-01 9.48e-03 9.78e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 9.51e-01 9.44e-03 9.85e-01
Signaling by NOTCH2 32 9.28e-01 9.26e-03 9.80e-01
Reactions specific to the complex N-glycan synthesis pathway 10 9.60e-01 -9.25e-03 9.89e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 9.37e-01 -9.15e-03 9.83e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 9.60e-01 -9.15e-03 9.89e-01
EPH-ephrin mediated repulsion of cells 50 9.12e-01 9.03e-03 9.75e-01
Diseases associated with the TLR signaling cascade 29 9.36e-01 8.59e-03 9.83e-01
Diseases of Immune System 29 9.36e-01 8.59e-03 9.83e-01
G-protein activation 24 9.43e-01 -8.50e-03 9.84e-01
Transcriptional regulation of white adipocyte differentiation 81 8.95e-01 8.45e-03 9.68e-01
TP53 Regulates Transcription of Cell Death Genes 43 9.25e-01 -8.33e-03 9.80e-01
Phase II - Conjugation of compounds 95 8.90e-01 8.24e-03 9.67e-01
RNA Polymerase I Promoter Clearance 71 9.05e-01 8.17e-03 9.73e-01
RNA Polymerase I Transcription 71 9.05e-01 8.17e-03 9.73e-01
RHOT1 GTPase cycle 5 9.75e-01 8.07e-03 9.99e-01
Glucagon-type ligand receptors 32 9.37e-01 -8.02e-03 9.83e-01
Hemostasis 564 7.45e-01 -8.02e-03 9.10e-01
Synthesis of very long-chain fatty acyl-CoAs 23 9.48e-01 -7.87e-03 9.84e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 32 9.39e-01 7.84e-03 9.83e-01
LDL clearance 19 9.53e-01 7.76e-03 9.86e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 9.43e-01 -7.74e-03 9.84e-01
SUMOylation of transcription cofactors 44 9.30e-01 7.64e-03 9.80e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 15 9.59e-01 -7.59e-03 9.89e-01
RUNX3 Regulates Immune Response and Cell Migration 6 9.74e-01 -7.59e-03 9.98e-01
Defective B4GALT7 causes EDS, progeroid type 17 9.57e-01 7.52e-03 9.89e-01
Glutathione conjugation 30 9.43e-01 -7.50e-03 9.84e-01
Defective B3GAT3 causes JDSSDHD 17 9.59e-01 -7.19e-03 9.89e-01
Transcriptional regulation by RUNX1 204 8.60e-01 7.19e-03 9.58e-01
Gene expression (Transcription) 1463 6.49e-01 7.12e-03 8.53e-01
Translation of Structural Proteins 9694635 55 9.29e-01 -6.92e-03 9.80e-01
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 8 9.73e-01 -6.80e-03 9.98e-01
CaM pathway 34 9.45e-01 6.78e-03 9.84e-01
Calmodulin induced events 34 9.45e-01 6.78e-03 9.84e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 9.54e-01 -6.74e-03 9.87e-01
Signaling by FGFR 87 9.16e-01 6.56e-03 9.77e-01
Intracellular signaling by second messengers 314 8.45e-01 6.44e-03 9.53e-01
Cytochrome P450 - arranged by substrate type 62 9.36e-01 -5.90e-03 9.83e-01
Synthesis of Lipoxins (LX) 6 9.80e-01 5.81e-03 9.99e-01
Uptake and function of diphtheria toxin 6 9.81e-01 5.63e-03 9.99e-01
ATF6 (ATF6-alpha) activates chaperones 11 9.74e-01 5.61e-03 9.98e-01
Common Pathway of Fibrin Clot Formation 21 9.65e-01 5.55e-03 9.92e-01
RHO GTPase cycle 418 8.54e-01 -5.25e-03 9.56e-01
STAT5 Activation 7 9.81e-01 5.18e-03 9.99e-01
Transcriptional Regulation by VENTX 41 9.59e-01 -4.68e-03 9.89e-01
Beta-catenin independent WNT signaling 145 9.24e-01 -4.58e-03 9.80e-01
Thromboxane signalling through TP receptor 24 9.70e-01 4.50e-03 9.96e-01
Pyroptosis 27 9.68e-01 4.49e-03 9.95e-01
CD28 dependent PI3K/Akt signaling 22 9.71e-01 4.42e-03 9.97e-01
Oncogene Induced Senescence 35 9.64e-01 -4.40e-03 9.92e-01
Carboxyterminal post-translational modifications of tubulin 43 9.60e-01 -4.38e-03 9.89e-01
Factors involved in megakaryocyte development and platelet production 143 9.28e-01 -4.36e-03 9.80e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 9.76e-01 4.20e-03 9.99e-01
Ion channel transport 172 9.27e-01 -4.03e-03 9.80e-01
Maternal to zygotic transition (MZT) 96 9.49e-01 -3.77e-03 9.85e-01
Estrogen-dependent gene expression 113 9.46e-01 -3.68e-03 9.84e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 20 9.82e-01 2.92e-03 9.99e-01
Cargo trafficking to the periciliary membrane 49 9.73e-01 -2.78e-03 9.98e-01
Netrin mediated repulsion signals 8 9.89e-01 2.69e-03 9.99e-01
Heme degradation 15 9.88e-01 2.22e-03 9.99e-01
NRIF signals cell death from the nucleus 16 9.89e-01 2.07e-03 9.99e-01
Interleukin-15 signaling 13 9.90e-01 -1.92e-03 9.99e-01
Prostacyclin signalling through prostacyclin receptor 19 9.88e-01 1.91e-03 9.99e-01
Circadian Clock 66 9.80e-01 1.80e-03 9.99e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 9.95e-01 1.74e-03 9.99e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 30 9.87e-01 -1.67e-03 9.99e-01
Post NMDA receptor activation events 75 9.81e-01 1.62e-03 9.99e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.93e-01 -1.55e-03 9.99e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 9.85e-01 1.51e-03 9.99e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 9.85e-01 1.51e-03 9.99e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 9.85e-01 1.51e-03 9.99e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 9.85e-01 1.51e-03 9.99e-01
Signaling by NOTCH1 in Cancer 54 9.85e-01 1.51e-03 9.99e-01
Suppression of apoptosis 7 9.95e-01 -1.45e-03 9.99e-01
ADORA2B mediated anti-inflammatory cytokines production 42 9.87e-01 1.45e-03 9.99e-01
GPER1 signaling 45 9.87e-01 -1.41e-03 9.99e-01
Signaling by ALK fusions and activated point mutants 91 9.82e-01 -1.36e-03 9.99e-01
Signaling by ALK in cancer 91 9.82e-01 -1.36e-03 9.99e-01
PRC2 methylates histones and DNA 35 9.90e-01 -1.27e-03 9.99e-01
DNA methylation 28 9.91e-01 -1.25e-03 9.99e-01
Role of phospholipids in phagocytosis 23 9.92e-01 -1.24e-03 9.99e-01
Metabolism of Angiotensinogen to Angiotensins 16 9.94e-01 -1.13e-03 9.99e-01
O-linked glycosylation of mucins 62 9.89e-01 -1.03e-03 9.99e-01
Maturation of protein 3a 9683673 9 9.96e-01 9.56e-04 9.99e-01
Maturation of protein 3a 9694719 9 9.96e-01 9.56e-04 9.99e-01
Plasma lipoprotein remodeling 33 9.93e-01 -9.15e-04 9.99e-01
Diseases of metabolism 238 9.81e-01 8.99e-04 9.99e-01
Transcriptional regulation of granulopoiesis 53 9.91e-01 8.91e-04 9.99e-01
Interleukin-21 signaling 9 9.96e-01 -8.84e-04 9.99e-01
RUNX3 regulates YAP1-mediated transcription 7 9.97e-01 7.27e-04 9.99e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 9.98e-01 -6.78e-04 9.99e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 9.96e-01 6.59e-04 9.99e-01
Vasopressin regulates renal water homeostasis via Aquaporins 42 9.95e-01 5.82e-04 9.99e-01
Detoxification of Reactive Oxygen Species 33 9.96e-01 4.77e-04 9.99e-01
Maturation of nucleoprotein 9694631 15 9.98e-01 4.20e-04 9.99e-01
PIP3 activates AKT signaling 275 9.93e-01 3.02e-04 9.99e-01
Glycogen synthesis 13 9.99e-01 2.99e-04 1.00e+00
Signaling by SCF-KIT 42 9.97e-01 2.87e-04 9.99e-01
rRNA modification in the mitochondrion 6 1.00e+00 -1.39e-04 1.00e+00
Presynaptic nicotinic acetylcholine receptors 12 1.00e+00 2.31e-05 1.00e+00


Detailed Gene set reports



Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
1454
set Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
setSize 5
pANOVA 0.00176
s.dist 0.808
p.adjustANOVA 0.0171



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEUROD1 7085
NKX2-2 6613
INSM1 6141
PAX4 5984
NEUROG3 2756

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEUROD1 7085
NKX2-2 6613
INSM1 6141
PAX4 5984
NEUROG3 2756


Regulation of gene expression in early pancreatic precursor cells

Regulation of gene expression in early pancreatic precursor cells
1453
set Regulation of gene expression in early pancreatic precursor cells
setSize 8
pANOVA 0.000142
s.dist 0.777
p.adjustANOVA 0.00293



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTF1A 7682
NKX6-1 7535
PDX1 6909
FGF10 6458
ONECUT1 5952
ONECUT3 4366
HNF1B 3754
NR5A2 361

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTF1A 7682
NKX6-1 7535
PDX1 6909
FGF10 6458
ONECUT1 5952
ONECUT3 4366
HNF1B 3754
NR5A2 361


Formation of lateral plate mesoderm

Formation of lateral plate mesoderm
594
set Formation of lateral plate mesoderm
setSize 5
pANOVA 0.00327
s.dist 0.76
p.adjustANOVA 0.027



Top enriched genes

Top 20 genes
GeneID Gene Rank
BMP4 6828
SHH 5995
IHH 5840
GATA4 5120
FOXF1 2191

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BMP4 6828
SHH 5995
IHH 5840
GATA4 5120
FOXF1 2191


Free fatty acid receptors

Free fatty acid receptors
609
set Free fatty acid receptors
setSize 5
pANOVA 0.00413
s.dist 0.74
p.adjustANOVA 0.0318



Top enriched genes

Top 20 genes
GeneID Gene Rank
GPR31 6524
FFAR2 5963
FFAR3 5673
FFAR4 5654
FFAR1 1130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPR31 6524
FFAR2 5963
FFAR3 5673
FFAR4 5654
FFAR1 1130


Formation of intermediate mesoderm

Formation of intermediate mesoderm
593
set Formation of intermediate mesoderm
setSize 8
pANOVA 0.00173
s.dist 0.639
p.adjustANOVA 0.0169



Top enriched genes

Top 20 genes
GeneID Gene Rank
FOXC1 7512
FOXC2 7449
LHX1 6834
BMP4 6828
OSR1 5694
FGF2 4461
PAX2 1106
PAX8 -8720

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXC1 7512
FOXC2 7449
LHX1 6834
BMP4 6828
OSR1 5694
FGF2 4461
PAX2 1106
PAX8 -8720


Formation of the ureteric bud

Formation of the ureteric bud
605
set Formation of the ureteric bud
setSize 21
pANOVA 5.43e-07
s.dist 0.631
p.adjustANOVA 1.96e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
HOXD11 7607
SALL1 7543
FOXC1 7512
FOXC2 7449
GDNF 7241
SIX1 7238
SIX2 7095
GREM1 6900
BMP4 6828
HOXC11 6682
SLIT2 5699
GFRA1 5556
NPNT 4933
HOXA11 4629
EYA1 2632
PAX2 1106
ROBO2 -559
WNT11 -857
ITGB1 -2169
ITGA8 -2572

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HOXD11 7607
SALL1 7543
FOXC1 7512
FOXC2 7449
GDNF 7241
SIX1 7238
SIX2 7095
GREM1 6900
BMP4 6828
HOXC11 6682
SLIT2 5699
GFRA1 5556
NPNT 4933
HOXA11 4629
EYA1 2632
PAX2 1106
ROBO2 -559
WNT11 -857
ITGB1 -2169
ITGA8 -2572
RET -10592


Thyroxine biosynthesis

Thyroxine biosynthesis
1824
set Thyroxine biosynthesis
setSize 10
pANOVA 0.000598
s.dist 0.627
p.adjustANOVA 0.00825



Top enriched genes

Top 20 genes
GeneID Gene Rank
DIO3 7712
IYD 7427
TSHB 6843
TPO 3986
DUOX2 3967
DIO1 3853
SLC5A5 3741
DUOX1 3573
DIO2 26
CGA -3551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DIO3 7712
IYD 7427
TSHB 6843
TPO 3986
DUOX2 3967
DIO1 3853
SLC5A5 3741
DUOX1 3573
DIO2 26
CGA -3551


Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation
1860
set Transcriptional regulation of testis differentiation
setSize 12
pANOVA 0.000205
s.dist 0.619
p.adjustANOVA 0.00397



Top enriched genes

Top 20 genes
GeneID Gene Rank
FOXL2 7169
SOX9 7018
WT1 6994
AMH 5643
ZFPM2 5392
DHH 5296
GATA4 5120
NR5A1 3821
WNT4 2387
DMRT1 598
FGF9 -758
PTGDS -4602

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXL2 7169
SOX9 7018
WT1 6994
AMH 5643
ZFPM2 5392
DHH 5296
GATA4 5120
NR5A1 3821
WNT4 2387
DMRT1 598
FGF9 -758
PTGDS -4602


Acrosome Reaction and Sperm:Oocyte Membrane Binding

Acrosome Reaction and Sperm:Oocyte Membrane Binding
40
set Acrosome Reaction and Sperm:Oocyte Membrane Binding
setSize 6
pANOVA 0.0117
s.dist -0.594
p.adjustANOVA 0.0701



Top enriched genes

Top 20 genes
GeneID Gene Rank
IZUMO3 -12485
IZUMO4 -12313
CD9 -12176
ACR -11794
IZUMO2 -8015
IZUMO1 139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IZUMO3 -12485
IZUMO4 -12313
CD9 -12176
ACR -11794
IZUMO2 -8015
IZUMO1 139


Electric Transmission Across Gap Junctions

Electric Transmission Across Gap Junctions
500
set Electric Transmission Across Gap Junctions
setSize 5
pANOVA 0.0216
s.dist 0.593
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
GJD2 7756
PANX2 3732
GJA10 2319
PANX1 1878
GJC1 1289

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GJD2 7756
PANX2 3732
GJA10 2319
PANX1 1878
GJC1 1289


Transmission across Electrical Synapses

Transmission across Electrical Synapses
1877
set Transmission across Electrical Synapses
setSize 5
pANOVA 0.0216
s.dist 0.593
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
GJD2 7756
PANX2 3732
GJA10 2319
PANX1 1878
GJC1 1289

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GJD2 7756
PANX2 3732
GJA10 2319
PANX1 1878
GJC1 1289


Defective LFNG causes SCDO3

Defective LFNG causes SCDO3
387
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0246
s.dist 0.58
p.adjustANOVA 0.125



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH2 5766
NOTCH3 4610
NOTCH1 4408
NOTCH4 964
LFNG 535

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH2 5766
NOTCH3 4610
NOTCH1 4408
NOTCH4 964
LFNG 535


Formation of the anterior neural plate

Formation of the anterior neural plate
599
set Formation of the anterior neural plate
setSize 10
pANOVA 0.00179
s.dist 0.57
p.adjustANOVA 0.0171



Top enriched genes

Top 20 genes
GeneID Gene Rank
GBX2 7640
SOX1 7384
PAX6 6300
OTX2 5859
SOX2 5767
ZIC2 5259
NANOG -15
POU3F1 -1529
ZNF521 -1750
ZEB2 -3454

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GBX2 7640
SOX1 7384
PAX6 6300
OTX2 5859
SOX2 5767
ZIC2 5259
NANOG -15
POU3F1 -1529
ZNF521 -1750
ZEB2 -3454


Cobalamin (Cbl) metabolism

Cobalamin (Cbl) metabolism
291
set Cobalamin (Cbl) metabolism
setSize 7
pANOVA 0.00939
s.dist -0.567
p.adjustANOVA 0.0602



Top enriched genes

Top 20 genes
GeneID Gene Rank
MMAB -13141
MMACHC -11705
MMADHC -9728
MTR -8606
MTRR -8265
MMAA -7323
MMUT -5236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMAB -13141
MMACHC -11705
MMADHC -9728
MTR -8606
MTRR -8265
MMAA -7323
MMUT -5236


Specification of the neural plate border

Specification of the neural plate border
1703
set Specification of the neural plate border
setSize 16
pANOVA 9.64e-05
s.dist 0.563
p.adjustANOVA 0.0021



Top enriched genes

Top 20 genes
GeneID Gene Rank
GBX2 7640
TFAP2C 7521
ZIC1 7144
PAX3 7062
BMP4 6828
TFAP2A 6066
SOX2 5767
DLX5 5470
MSX1 5403
FGF4 4269
TFAP2B 4229
PAX7 -480
WNT3A -2308
CTNNB1 -3925
MYB -4149
TCF7L1 -7472

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GBX2 7640
TFAP2C 7521
ZIC1 7144
PAX3 7062
BMP4 6828
TFAP2A 6066
SOX2 5767
DLX5 5470
MSX1 5403
FGF4 4269
TFAP2B 4229
PAX7 -480
WNT3A -2308
CTNNB1 -3925
MYB -4149
TCF7L1 -7472


Hyaluronan biosynthesis and export

Hyaluronan biosynthesis and export
746
set Hyaluronan biosynthesis and export
setSize 5
pANOVA 0.031
s.dist 0.557
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
HAS3 6591
HAS2 5547
HAS1 2881
CEMIP 846
ABCC5 -840

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HAS3 6591
HAS2 5547
HAS1 2881
CEMIP 846
ABCC5 -840


POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
1166
set POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
setSize 9
pANOVA 0.0044
s.dist 0.548
p.adjustANOVA 0.0333



Top enriched genes

Top 20 genes
GeneID Gene Rank
GSC 7539
HHEX 7424
DKK1 7070
GATA6 6502
CDX2 6281
SOX2 5767
NANOG -15
TSC22D1 -3977
EOMES -10410

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GSC 7539
HHEX 7424
DKK1 7070
GATA6 6502
CDX2 6281
SOX2 5767
NANOG -15
TSC22D1 -3977
EOMES -10410


Adrenoceptors

Adrenoceptors
95
set Adrenoceptors
setSize 9
pANOVA 0.00443
s.dist 0.548
p.adjustANOVA 0.0334



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADRA2C 7213
ADRB1 6159
ADRA1A 6076
ADRA2B 5991
ADRA1B 4915
ADRA2A 4291
ADRB3 3583
ADRA1D -1153
ADRB2 -10943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADRA2C 7213
ADRB1 6159
ADRA1A 6076
ADRA2B 5991
ADRA1B 4915
ADRA2A 4291
ADRB3 3583
ADRA1D -1153
ADRB2 -10943


Vasopressin-like receptors

Vasopressin-like receptors
1928
set Vasopressin-like receptors
setSize 5
pANOVA 0.0346
s.dist 0.546
p.adjustANOVA 0.159



Top enriched genes

Top 20 genes
GeneID Gene Rank
AVPR1A 7672
AVPR1B 6807
AVP 4139
OXT 1164
OXTR -5369

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AVPR1A 7672
AVPR1B 6807
AVP 4139
OXT 1164
OXTR -5369


Kidney development

Kidney development
857
set Kidney development
setSize 45
pANOVA 2.62e-10
s.dist 0.544
p.adjustANOVA 2.52e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRX2 7751
POU3F3 7673
HOXD11 7607
SALL1 7543
IRX1 7534
FOXC1 7512
FOXC2 7449
ID4 7372
GDNF 7241
SIX1 7238
SIX2 7095
WT1 6994
GREM1 6900
EMX2 6889
LHX1 6834
BMP4 6828
HOXC11 6682
HOXA6 6608
WNT9B 6351
SLIT2 5699

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRX2 7751
POU3F3 7673
HOXD11 7607
SALL1 7543
IRX1 7534
FOXC1 7512
FOXC2 7449
ID4 7372
GDNF 7241
SIX1 7238
SIX2 7095
WT1 6994
GREM1 6900
EMX2 6889
LHX1 6834
BMP4 6828
HOXC11 6682
HOXA6 6608
WNT9B 6351
SLIT2 5699
OSR1 5694
GFRA1 5556
NPNT 4933
WFDC2 4815
HOXA11 4629
FGF2 4461
HNF1B 3754
EYA1 2632
WNT4 2387
HOXB4 2134
PAX2 1106
LFNG 535
ROBO2 -559
PLAC8 -593
WNT11 -857
ITGB1 -2169
ITGA8 -2572
MECOM -3193
CTNNB1 -3925
DLL1 -4687
JAG1 -5327
GATA3 -5746
HNF4A -6961
PAX8 -8720
RET -10592


CREB3 factors activate genes

CREB3 factors activate genes
210
set CREB3 factors activate genes
setSize 8
pANOVA 0.00862
s.dist -0.536
p.adjustANOVA 0.0565



Top enriched genes

Top 20 genes
GeneID Gene Rank
CREB3L1 -11728
CREB3L4 -11262
CREB3 -10940
CREBRF -9733
CREB3L3 -8729
DCSTAMP -7935
MBTPS1 -7201
CREB3L2 -2969

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CREB3L1 -11728
CREB3L4 -11262
CREB3 -10940
CREBRF -9733
CREB3L3 -8729
DCSTAMP -7935
MBTPS1 -7201
CREB3L2 -2969


Alpha-oxidation of phytanate

Alpha-oxidation of phytanate
100
set Alpha-oxidation of phytanate
setSize 6
pANOVA 0.0232
s.dist -0.535
p.adjustANOVA 0.12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PECR -12033
SLC27A2 -12018
SLC25A17 -8858
PHYH -8684
HACL1 -7794
ALDH3A2 -3419

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PECR -12033
SLC27A2 -12018
SLC25A17 -8858
PHYH -8684
HACL1 -7794
ALDH3A2 -3419


Dopamine receptors

Dopamine receptors
455
set Dopamine receptors
setSize 5
pANOVA 0.0403
s.dist 0.53
p.adjustANOVA 0.174



Top enriched genes

Top 20 genes
GeneID Gene Rank
DRD5 7401
DRD3 3753
DRD1 2554
DRD4 1745
DRD2 -1906

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DRD5 7401
DRD3 3753
DRD1 2554
DRD4 1745
DRD2 -1906


Nephron development

Nephron development
1073
set Nephron development
setSize 13
pANOVA 0.00115
s.dist 0.521
p.adjustANOVA 0.0124



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRX2 7751
POU3F3 7673
IRX1 7534
WT1 6994
LHX1 6834
WNT9B 6351
HNF1B 3754
WNT4 2387
PAX2 1106
LFNG 535
DLL1 -4687
JAG1 -5327
HNF4A -6961

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRX2 7751
POU3F3 7673
IRX1 7534
WT1 6994
LHX1 6834
WNT9B 6351
HNF1B 3754
WNT4 2387
PAX2 1106
LFNG 535
DLL1 -4687
JAG1 -5327
HNF4A -6961


Neurotransmitter clearance

Neurotransmitter clearance
1082
set Neurotransmitter clearance
setSize 9
pANOVA 0.00857
s.dist 0.506
p.adjustANOVA 0.0565



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC22A1 6648
ALDH2 5090
SLC22A2 4871
ACHE 3665
SLC6A3 3394
COMT 1884
LRTOMT 1086
BCHE 194
SLC6A4 -4755

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC22A1 6648
ALDH2 5090
SLC22A2 4871
ACHE 3665
SLC6A3 3394
COMT 1884
LRTOMT 1086
BCHE 194
SLC6A4 -4755


Erythropoietin activates STAT5

Erythropoietin activates STAT5
515
set Erythropoietin activates STAT5
setSize 7
pANOVA 0.0219
s.dist 0.5
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRS2 7205
EPO 6777
EPOR 4419
STAT5A -39
JAK2 -279
STAT5B -648
LYN -687

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 7205
EPO 6777
EPOR 4419
STAT5A -39
JAK2 -279
STAT5B -648
LYN -687


Metal sequestration by antimicrobial proteins

Metal sequestration by antimicrobial proteins
958
set Metal sequestration by antimicrobial proteins
setSize 5
pANOVA 0.0541
s.dist -0.497
p.adjustANOVA 0.216



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A7 -13661
LCN2 -12365
LTF -11687
S100A8 -9998
S100A9 5753

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A7 -13661
LCN2 -12365
LTF -11687
S100A8 -9998
S100A9 5753


Vitamins

Vitamins
1940
set Vitamins
setSize 6
pANOVA 0.0352
s.dist 0.497
p.adjustANOVA 0.161



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP26A1 6181
CYP26B1 6122
CYP26C1 5370
CYP24A1 4765
CYP27B1 4674
CYP2R1 -13006

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP26A1 6181
CYP26B1 6122
CYP26C1 5370
CYP24A1 4765
CYP27B1 4674
CYP2R1 -13006


Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Negative regulation of activity of TFAP2 (AP-2) family transcription factors
1069
set Negative regulation of activity of TFAP2 (AP-2) family transcription factors
setSize 10
pANOVA 0.00759
s.dist 0.487
p.adjustANOVA 0.0512



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFAP2C 7521
TFAP2D 6094
TFAP2A 6066
TFAP2B 4229
KCTD15 4180
TFAP2E 2219
UBE2I 839
WWOX -407
KCTD1 -3032
SUMO1 -5183

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFAP2C 7521
TFAP2D 6094
TFAP2A 6066
TFAP2B 4229
KCTD15 4180
TFAP2E 2219
UBE2I 839
WWOX -407
KCTD1 -3032
SUMO1 -5183


Prednisone ADME

Prednisone ADME
1242
set Prednisone ADME
setSize 9
pANOVA 0.0124
s.dist 0.481
p.adjustANOVA 0.0727



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKR1C1 6441
CYP3A4 4425
ABCB1 4148
UGT2B7 2887
HSD11B1 2702
ALB 2367
SERPINA6 1971
HSD11B2 -1399
UGT1A3 -3863

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKR1C1 6441
CYP3A4 4425
ABCB1 4148
UGT2B7 2887
HSD11B1 2702
ALB 2367
SERPINA6 1971
HSD11B2 -1399
UGT1A3 -3863


Signaling by RNF43 mutants

Signaling by RNF43 mutants
1669
set Signaling by RNF43 mutants
setSize 8
pANOVA 0.0196
s.dist 0.476
p.adjustANOVA 0.106



Top enriched genes

Top 20 genes
GeneID Gene Rank
FZD8 7698
FZD6 6503
FZD4 1915
LRP5 1122
LRP6 1052
RNF43 929
FZD5 163
WNT3A -2308

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FZD8 7698
FZD6 6503
FZD4 1915
LRP5 1122
LRP6 1052
RNF43 929
FZD5 163
WNT3A -2308


Recycling of eIF2:GDP

Recycling of eIF2:GDP
1394
set Recycling of eIF2:GDP
setSize 7
pANOVA 0.0293
s.dist -0.476
p.adjustANOVA 0.142



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2B4 -12225
EIF2B1 -11315
EIF2S2 -9683
EIF2B5 -9281
EIF2B2 -7948
EIF2B3 -3448
EIF2S1 -3192

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2B4 -12225
EIF2B1 -11315
EIF2S2 -9683
EIF2B5 -9281
EIF2B2 -7948
EIF2B3 -3448
EIF2S1 -3192


Sensing of DNA Double Strand Breaks

Sensing of DNA Double Strand Breaks
1578
set Sensing of DNA Double Strand Breaks
setSize 6
pANOVA 0.0448
s.dist -0.473
p.adjustANOVA 0.187



Top enriched genes

Top 20 genes
GeneID Gene Rank
KPNA2 -12010
KAT5 -9796
NBN -8681
RAD50 -8372
ATM -5027
MRE11 -4883

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KPNA2 -12010
KAT5 -9796
NBN -8681
RAD50 -8372
ATM -5027
MRE11 -4883


Organic anion transport

Organic anion transport
1128
set Organic anion transport
setSize 5
pANOVA 0.0693
s.dist -0.469
p.adjustANOVA 0.255



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC22A7 -11885
SLC22A6 -11455
SLC22A8 -10549
SLC22A12 -3638
SLC22A11 -2902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC22A7 -11885
SLC22A6 -11455
SLC22A8 -10549
SLC22A12 -3638
SLC22A11 -2902


Ligand-receptor interactions

Ligand-receptor interactions
878
set Ligand-receptor interactions
setSize 8
pANOVA 0.0237
s.dist 0.462
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
SHH 5995
IHH 5840
DHH 5296
HHIP 3520
GAS1 2312
PTCH1 1814
BOC 103
CDON -9075

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SHH 5995
IHH 5840
DHH 5296
HHIP 3520
GAS1 2312
PTCH1 1814
BOC 103
CDON -9075


Defective F9 activation

Defective F9 activation
380
set Defective F9 activation
setSize 5
pANOVA 0.0782
s.dist 0.455
p.adjustANOVA 0.277



Top enriched genes

Top 20 genes
GeneID Gene Rank
GP1BA 5489
GP1BB 4989
GP5 4726
F11 -195
GP9 -5510

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA 5489
GP1BB 4989
GP5 4726
F11 -195
GP9 -5510


Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion
516
set Establishment of Sister Chromatid Cohesion
setSize 9
pANOVA 0.0193
s.dist -0.45
p.adjustANOVA 0.105



Top enriched genes

Top 20 genes
GeneID Gene Rank
SMC3 -12847
CDCA5 -11540
ESCO1 -9473
PDS5B -9133
RAD21 -8276
WAPL -6014
ESCO2 -5754
PDS5A -4655
STAG1 -3268

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMC3 -12847
CDCA5 -11540
ESCO1 -9473
PDS5B -9133
RAD21 -8276
WAPL -6014
ESCO2 -5754
PDS5A -4655
STAG1 -3268


Activation of TRKA receptors

Activation of TRKA receptors
73
set Activation of TRKA receptors
setSize 6
pANOVA 0.058
s.dist 0.447
p.adjustANOVA 0.225



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADCYAP1 6673
NGF 5472
NTRK2 4541
ADCYAP1R1 1920
ADORA2A -1611
NTRK1 -6109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADCYAP1 6673
NGF 5472
NTRK2 4541
ADCYAP1R1 1920
ADORA2A -1611
NTRK1 -6109


Calcitonin-like ligand receptors

Calcitonin-like ligand receptors
225
set Calcitonin-like ligand receptors
setSize 10
pANOVA 0.015
s.dist 0.444
p.adjustANOVA 0.0859



Top enriched genes

Top 20 genes
GeneID Gene Rank
IAPP 7097
CALCB 4835
RAMP2 4816
CALCR 2692
CALCA 2540
RAMP1 1570
ADM 827
CALCRL 411
ADM2 -2571
RAMP3 -4348

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IAPP 7097
CALCB 4835
RAMP2 4816
CALCR 2692
CALCA 2540
RAMP1 1570
ADM 827
CALCRL 411
ADM2 -2571
RAMP3 -4348


Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
578
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.0157
s.dist -0.441
p.adjustANOVA 0.0882



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACTB -12523.0
CCT6A -12153.0
CCT5 -10296.0
CCT3 -9342.0
CCT7 -8556.0
CCT8 -8305.0
CCT6B -8181.5
CCT2 -6944.0
CCT4 -1631.0
TCP1 75.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACTB -12523.0
CCT6A -12153.0
CCT5 -10296.0
CCT3 -9342.0
CCT7 -8556.0
CCT8 -8305.0
CCT6B -8181.5
CCT2 -6944.0
CCT4 -1631.0
TCP1 75.0


RUNX1 regulates transcription of genes involved in WNT signaling

RUNX1 regulates transcription of genes involved in WNT signaling
1365
set RUNX1 regulates transcription of genes involved in WNT signaling
setSize 5
pANOVA 0.0892
s.dist 0.439
p.adjustANOVA 0.302



Top enriched genes

Top 20 genes
GeneID Gene Rank
RSPO3 5684
ESR1 3251
AXIN1 3158
CBFB -493
RUNX1 -2954

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RSPO3 5684
ESR1 3251
AXIN1 3158
CBFB -493
RUNX1 -2954


Tandem pore domain potassium channels

Tandem pore domain potassium channels
1804
set Tandem pore domain potassium channels
setSize 12
pANOVA 0.0101
s.dist 0.429
p.adjustANOVA 0.0631



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK1 7359
KCNK17 6912
KCNK2 5866
KCNK10 4130
KCNK4 4051
KCNK3 3012
KCNK16 2436
KCNK6 -390
KCNK7 -2031
KCNK9 -3113
KCNK13 -3985
KCNK18 -4809

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK1 7359
KCNK17 6912
KCNK2 5866
KCNK10 4130
KCNK4 4051
KCNK3 3012
KCNK16 2436
KCNK6 -390
KCNK7 -2031
KCNK9 -3113
KCNK13 -3985
KCNK18 -4809


CD22 mediated BCR regulation

CD22 mediated BCR regulation
190
set CD22 mediated BCR regulation
setSize 5
pANOVA 0.0981
s.dist 0.427
p.adjustANOVA 0.32



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD79B 5404
CD79A 5204
PTPN6 2317
LYN -687
CD22 -4233

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD79B 5404
CD79A 5204
PTPN6 2317
LYN -687
CD22 -4233


Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis
993
set Mitotic Telophase/Cytokinesis
setSize 11
pANOVA 0.0158
s.dist -0.42
p.adjustANOVA 0.0882



Top enriched genes

Top 20 genes
GeneID Gene Rank
SMC3 -12847
PDS5B -9133
PLK1 -8560
RAD21 -8276
MAU2 -7982
KIF23 -7928
NIPBL -7444
KIF20A -7046
WAPL -6014
PDS5A -4655
STAG1 -3268

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMC3 -12847
PDS5B -9133
PLK1 -8560
RAD21 -8276
MAU2 -7982
KIF23 -7928
NIPBL -7444
KIF20A -7046
WAPL -6014
PDS5A -4655
STAG1 -3268


Phosphorylation of Emi1

Phosphorylation of Emi1
1210
set Phosphorylation of Emi1
setSize 6
pANOVA 0.0761
s.dist -0.418
p.adjustANOVA 0.272



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC20 -12514
CDK1 -11603
PLK1 -8560
CCNB1 -5456
FBXO5 -5339
FZR1 -1747

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC20 -12514
CDK1 -11603
PLK1 -8560
CCNB1 -5456
FBXO5 -5339
FZR1 -1747


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1543
set SRP-dependent cotranslational protein targeting to membrane
setSize 105
pANOVA 1.29e-13
s.dist -0.418
p.adjustANOVA 2.58e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS28 -13541
RPS11 -13428
SEC61G -13400
SPCS2 -12999
SPCS1 -12994
RPLP1 -12918
RPS14 -12770
RPL13 -12670
RPL12 -12650
RPL10A -12605
RPS6 -12572
FAU -12534
SRP9 -12498
SEC11C -12481
RPL29 -12480
RPL6 -12413
RPS21 -12316
RPL39L -11987
RPL27A -11974
RPS7 -11943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS28 -13541.0
RPS11 -13428.0
SEC61G -13400.0
SPCS2 -12999.0
SPCS1 -12994.0
RPLP1 -12918.0
RPS14 -12770.0
RPL13 -12670.0
RPL12 -12650.0
RPL10A -12605.0
RPS6 -12572.0
FAU -12534.0
SRP9 -12498.0
SEC11C -12481.0
RPL29 -12480.0
RPL6 -12413.0
RPS21 -12316.0
RPL39L -11987.0
RPL27A -11974.0
RPS7 -11943.0
SEC61B -11605.0
RPL8 -11489.0
RPS8 -11311.0
RPL37 -11305.0
SPCS3 -11213.0
RPLP0 -11116.0
RPL26 -10923.0
RPL7A -10757.0
RPL15 -10752.0
SRP72 -10600.0
RPS15A -10582.0
SRP19 -10542.0
SRPRB -10480.0
RPS29 -10460.0
UBA52 -10435.0
RPS10 -10322.0
RPLP2 -10184.0
RPL35 -10155.0
RPS25 -10059.0
RPN1 -9916.0
RPL11 -9397.0
RPS13 -9323.0
RPL28 -9178.0
RPL24 -9053.0
RPS12 -8926.0
SSR1 -8917.0
SRPRA -8469.0
RPS15 -8457.0
SRP54 -8306.0
RPS19 -8292.0
RPS20 -8288.0
RPL14 -8223.0
RPL36 -8172.0
RPL23A -8167.0
RPL38 -7923.0
DDOST -7877.0
RPL36AL -7843.5
RPL22L1 -7745.0
RPL7 -7726.0
RPL5 -7632.0
RPL37A -7492.0
RPS27L -7459.0
RPN2 -7281.0
RPL3L -7129.0
RPL3 -6892.0
SEC61A1 -6817.0
RPL18 -6805.0
RPL13A -6656.5
SSR3 -6411.0
SEC61A2 -6408.0
RPS5 -6402.0
SEC11A -6169.0
SRP68 -6160.0
SRP14 -5864.0
RPS2 -5663.0
RPSA -5606.0
RPL30 -5110.0
RPS18 -4888.0
RPL32 -4258.0
RPL23 -4078.0
RPS3A -3946.0
RPL9 -3912.0
RPL17 -3404.0
RPS24 -3309.0
RPL35A -3266.0
RPS3 -2565.0
RPL4 -2514.0
RPS23 -2118.0
RPL34 -2114.0
RPL27 -1911.0
RPS27 -1878.0
TRAM1 -1798.0
RPL21 -1456.0
RPL26L1 -1390.0
RPL31 -1289.0
RPS26 -979.0
SSR2 -967.0
RPL22 -935.0
RPL18A -912.0
RPS27A -676.0
RPL41 -432.0
RPS9 351.0
RPL19 638.0
RPS16 4527.0
RPL10L 6016.0


Formation of the nephric duct

Formation of the nephric duct
602
set Formation of the nephric duct
setSize 17
pANOVA 0.00307
s.dist 0.415
p.adjustANOVA 0.026



Top enriched genes

Top 20 genes
GeneID Gene Rank
ID4 7372
EMX2 6889
LHX1 6834
BMP4 6828
HOXA6 6608
OSR1 5694
NPNT 4933
WFDC2 4815
FGF2 4461
HOXB4 2134
PAX2 1106
PLAC8 -593
MECOM -3193
CTNNB1 -3925
GATA3 -5746
PAX8 -8720
RET -10592

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ID4 7372
EMX2 6889
LHX1 6834
BMP4 6828
HOXA6 6608
OSR1 5694
NPNT 4933
WFDC2 4815
FGF2 4461
HOXB4 2134
PAX2 1106
PLAC8 -593
MECOM -3193
CTNNB1 -3925
GATA3 -5746
PAX8 -8720
RET -10592


Cellular response to mitochondrial stress

Cellular response to mitochondrial stress
257
set Cellular response to mitochondrial stress
setSize 8
pANOVA 0.0424
s.dist -0.414
p.adjustANOVA 0.18



Top enriched genes

Top 20 genes
GeneID Gene Rank
DELE1 -11224
EIF2S2 -9683
YME1L1 -9495
PHB2 -8690
EIF2AK1 -7118
STOML2 -6184
OMA1 -4374
EIF2S1 -3192

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DELE1 -11224
EIF2S2 -9683
YME1L1 -9495
PHB2 -8690
EIF2AK1 -7118
STOML2 -6184
OMA1 -4374
EIF2S1 -3192


Formation of xylulose-5-phosphate

Formation of xylulose-5-phosphate
607
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.109
s.dist -0.414
p.adjustANOVA 0.343



Top enriched genes

Top 20 genes
GeneID Gene Rank
DCXR -12435
AKR1A1 -10988
SORD -10276
CRYL1 -3142
XYLB -598

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DCXR -12435
AKR1A1 -10988
SORD -10276
CRYL1 -3142
XYLB -598


Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin
294
set Cohesin Loading onto Chromatin
setSize 8
pANOVA 0.0444
s.dist -0.41
p.adjustANOVA 0.187



Top enriched genes

Top 20 genes
GeneID Gene Rank
SMC3 -12847
PDS5B -9133
RAD21 -8276
MAU2 -7982
NIPBL -7444
WAPL -6014
PDS5A -4655
STAG1 -3268

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMC3 -12847
PDS5B -9133
RAD21 -8276
MAU2 -7982
NIPBL -7444
WAPL -6014
PDS5A -4655
STAG1 -3268


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.2.0                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gplots_3.1.3                                       
##  [6] gtools_3.9.5                                       
##  [7] tibble_3.2.1                                       
##  [8] dplyr_1.1.4                                        
##  [9] echarts4r_0.4.5                                    
## [10] png_0.1-8                                          
## [11] gridExtra_2.3                                      
## [12] missMethyl_1.36.0                                  
## [13] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [14] beeswarm_0.4.0                                     
## [15] kableExtra_1.3.4                                   
## [16] mitch_1.15.0                                       
## [17] tictoc_1.2                                         
## [18] HGNChelper_0.8.1                                   
## [19] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [20] IlluminaHumanMethylation450kmanifest_0.4.0         
## [21] minfi_1.48.0                                       
## [22] bumphunter_1.44.0                                  
## [23] locfit_1.5-9.8                                     
## [24] iterators_1.0.14                                   
## [25] foreach_1.5.2                                      
## [26] Biostrings_2.70.1                                  
## [27] XVector_0.42.0                                     
## [28] SummarizedExperiment_1.32.0                        
## [29] Biobase_2.62.0                                     
## [30] MatrixGenerics_1.14.0                              
## [31] matrixStats_1.2.0                                  
## [32] GenomicRanges_1.54.1                               
## [33] GenomeInfoDb_1.38.1                                
## [34] IRanges_2.36.0                                     
## [35] S4Vectors_0.40.1                                   
## [36] BiocGenerics_0.48.1                                
## [37] eulerr_7.0.0                                       
## [38] limma_3.58.1                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.2              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.3            preprocessCore_1.64.0    
##   [7] XML_3.99-0.16             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.8               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.8                httpuv_1.6.13            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.2.0                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.3             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.6                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] webshot_0.5.5             illuminaio_0.44.0        
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.8           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.3           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] SparseArray_1.2.2         xfun_0.41                
##  [55] HDF5Array_1.30.0          withr_2.5.2              
##  [57] fastmap_1.1.1             rhdf5filters_1.14.1      
##  [59] fansi_1.0.6               openssl_2.1.1            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.58.0           
##  [67] RSQLite_2.3.4             utf8_1.2.4               
##  [69] tidyr_1.3.0               generics_0.1.3           
##  [71] data.table_1.14.10        rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.4         S4Arrays_1.2.0           
##  [77] ggstats_0.5.1             pkgconfig_2.0.3          
##  [79] gtable_0.3.4              blob_1.2.4               
##  [81] siggenes_1.76.0           htmltools_0.5.7          
##  [83] scales_1.3.0              rstudioapi_0.15.0        
##  [85] knitr_1.45                tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-164             
##  [89] curl_5.2.0                org.Hs.eg.db_3.18.0      
##  [91] cachem_1.0.8              rhdf5_2.46.0             
##  [93] stringr_1.5.1             KernSmooth_2.23-22       
##  [95] AnnotationDbi_1.64.1      restfulr_0.0.15          
##  [97] GEOquery_2.70.0           pillar_1.9.0             
##  [99] grid_4.3.2                reshape_0.8.9            
## [101] vctrs_0.6.5               promises_1.2.1           
## [103] dbplyr_2.4.0              xtable_1.8-4             
## [105] evaluate_0.23             readr_2.1.4              
## [107] GenomicFeatures_1.54.1    cli_3.6.2                
## [109] compiler_4.3.2            Rsamtools_2.18.0         
## [111] rlang_1.1.2               crayon_1.5.2             
## [113] rngtools_1.5.2            nor1mix_1.3-2            
## [115] mclust_6.0.1              plyr_1.8.9               
## [117] stringi_1.8.3             viridisLite_0.4.2        
## [119] BiocParallel_1.36.0       munsell_0.5.0            
## [121] Matrix_1.6-4              hms_1.1.3                
## [123] sparseMatrixStats_1.14.0  bit64_4.0.5              
## [125] Rhdf5lib_1.24.0           KEGGREST_1.42.0          
## [127] statmod_1.5.0             shiny_1.8.0              
## [129] highr_0.10                memoise_2.0.1.9000       
## [131] bslib_0.6.1               bit_4.0.5

END of report