Mitch Report

date generated: 2021-05-25

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                t
## A1BG   0.0412627
## AAAS   0.2317684
## AACS   0.4461738
## AAGAB -0.8398882
## AAK1   1.5132512
## AAMP  -0.6831837

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	2484
num_genes_in_profile	9869
duplicated_genes_present	0
num_profile_genes_in_sets	5319
num_profile_genes_not_in_sets	4550

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	2484
num_genesets_excluded	1343
num_genesets_included	1141

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 20 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Metabolism of RNA	498	1.38e-06	0.128	0.00158
Mitotic Metaphase and Anaphase	186	8.41e-05	0.168	0.03800
Mitotic Anaphase	185	1.13e-04	0.165	0.03800
Translation	225	1.33e-04	0.149	0.03800
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	2.42e-04	0.547	0.04490
PLC beta mediated events	29	2.92e-04	-0.389	0.04490
DAG and IP3 signaling	26	3.63e-04	-0.404	0.04490
Regulation of expression of SLITs and ROBOs	117	4.73e-04	0.188	0.04490
Selenocysteine synthesis	65	4.77e-04	0.251	0.04490
Signaling by GPCR	195	5.88e-04	-0.144	0.04490
Mitochondrial translation elongation	81	6.64e-04	0.219	0.04490
Integrin cell surface interactions	23	7.16e-04	-0.408	0.04490
Peptide chain elongation	64	7.50e-04	0.244	0.04490
rRNA processing	149	7.96e-04	0.160	0.04490
L13a-mediated translational silencing of Ceruloplasmin expression	82	8.39e-04	0.214	0.04490
GTP hydrolysis and joining of the 60S ribosomal subunit	83	9.39e-04	0.211	0.04490
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	9.67e-04	0.550	0.04490
Signaling by ROBO receptors	146	9.79e-04	0.159	0.04490
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	69	9.92e-04	0.230	0.04490
rRNA processing in the nucleus and cytosol	145	9.99e-04	0.159	0.04490

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
Metabolism of RNA	498	1.38e-06	1.28e-01	0.00158
Mitotic Metaphase and Anaphase	186	8.41e-05	1.68e-01	0.03800
Mitotic Anaphase	185	1.13e-04	1.65e-01	0.03800
Translation	225	1.33e-04	1.49e-01	0.03800
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	2.42e-04	5.47e-01	0.04490
PLC beta mediated events	29	2.92e-04	-3.89e-01	0.04490
DAG and IP3 signaling	26	3.63e-04	-4.04e-01	0.04490
Regulation of expression of SLITs and ROBOs	117	4.73e-04	1.88e-01	0.04490
Selenocysteine synthesis	65	4.77e-04	2.51e-01	0.04490
Signaling by GPCR	195	5.88e-04	-1.44e-01	0.04490
Mitochondrial translation elongation	81	6.64e-04	2.19e-01	0.04490
Integrin cell surface interactions	23	7.16e-04	-4.08e-01	0.04490
Peptide chain elongation	64	7.50e-04	2.44e-01	0.04490
rRNA processing	149	7.96e-04	1.60e-01	0.04490
L13a-mediated translational silencing of Ceruloplasmin expression	82	8.39e-04	2.14e-01	0.04490
GTP hydrolysis and joining of the 60S ribosomal subunit	83	9.39e-04	2.11e-01	0.04490
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	9.67e-04	5.50e-01	0.04490
Signaling by ROBO receptors	146	9.79e-04	1.59e-01	0.04490
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	69	9.92e-04	2.30e-01	0.04490
rRNA processing in the nucleus and cytosol	145	9.99e-04	1.59e-01	0.04490
GPCR downstream signalling	178	1.01e-03	-1.44e-01	0.04490
Activated NOTCH1 Transmits Signal to the Nucleus	19	1.01e-03	4.36e-01	0.04490
Separation of Sister Chromatids	141	1.01e-03	1.61e-01	0.04490
Mitochondrial translation	86	1.04e-03	2.05e-01	0.04490
Inositol phosphate metabolism	29	1.09e-03	-3.51e-01	0.04490
Translesion Synthesis by POLH	16	1.09e-03	4.72e-01	0.04490
SRP-dependent cotranslational protein targeting to membrane	81	1.13e-03	2.10e-01	0.04490
DNA Repair	232	1.18e-03	1.24e-01	0.04490
Mitochondrial translation termination	80	1.20e-03	2.10e-01	0.04490
Major pathway of rRNA processing in the nucleolus and cytosol	140	1.27e-03	1.58e-01	0.04490
Selenoamino acid metabolism	73	1.38e-03	2.17e-01	0.04490
Eukaryotic Translation Elongation	67	1.46e-03	2.25e-01	0.04490
CaM pathway	20	1.49e-03	-4.10e-01	0.04490
Calmodulin induced events	20	1.49e-03	-4.10e-01	0.04490
APC/C-mediated degradation of cell cycle proteins	73	1.55e-03	2.15e-01	0.04490
Regulation of mitotic cell cycle	73	1.55e-03	2.15e-01	0.04490
Mitochondrial translation initiation	81	1.57e-03	2.04e-01	0.04490
Signal Transduction	1263	1.58e-03	-5.50e-02	0.04490
PI3K/AKT Signaling in Cancer	50	1.58e-03	-2.59e-01	0.04490
Metabolism of proteins	1217	1.64e-03	5.57e-02	0.04490
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	81	1.70e-03	2.02e-01	0.04490
Nonsense-Mediated Decay (NMD)	81	1.70e-03	2.02e-01	0.04490
Eukaryotic Translation Termination	66	1.79e-03	2.23e-01	0.04490
Ca-dependent events	21	1.80e-03	-3.94e-01	0.04490
Anti-inflammatory response favouring Leishmania parasite infection	51	1.85e-03	-2.52e-01	0.04490
Leishmania parasite growth and survival	51	1.85e-03	-2.52e-01	0.04490
APC-Cdc20 mediated degradation of Nek2A	21	1.86e-03	3.92e-01	0.04490
Extracellular matrix organization	75	1.90e-03	-2.08e-01	0.04490
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	59	1.96e-03	2.33e-01	0.04490
G-protein mediated events	32	2.02e-03	-3.16e-01	0.04490
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	58	2.03e-03	2.35e-01	0.04490
Muscle contraction	64	2.05e-03	-2.23e-01	0.04490
Signaling by NOTCH2	18	2.08e-03	4.19e-01	0.04490
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	60	2.15e-03	2.29e-01	0.04540
Formation of a pool of free 40S subunits	73	2.21e-03	2.08e-01	0.04590
DNA Damage Recognition in GG-NER	35	2.38e-03	2.97e-01	0.04860
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	2.45e-03	3.10e-01	0.04900
Intracellular signaling by second messengers	197	2.55e-03	-1.25e-01	0.04910
APC/C:Cdc20 mediated degradation of Securin	54	2.58e-03	2.37e-01	0.04910
APC/C:Cdc20 mediated degradation of mitotic proteins	61	2.58e-03	2.23e-01	0.04910
M Phase	272	2.64e-03	1.07e-01	0.04930
Viral mRNA Translation	65	2.70e-03	2.16e-01	0.04970
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	62	3.07e-03	2.18e-01	0.05550
Defective CFTR causes cystic fibrosis	51	3.16e-03	2.39e-01	0.05630
CDT1 association with the CDC6:ORC:origin complex	44	3.27e-03	2.57e-01	0.05740
DNA Replication Pre-Initiation	66	3.35e-03	2.09e-01	0.05790
TICAM1-dependent activation of IRF3/IRF7	12	3.51e-03	4.87e-01	0.05890
SUMOylation of DNA methylation proteins	14	3.56e-03	-4.50e-01	0.05890
G alpha (i) signalling events	85	3.58e-03	-1.83e-01	0.05890
FCGR3A-mediated IL10 synthesis	22	3.61e-03	-3.59e-01	0.05890
Cell Cycle, Mitotic	390	3.71e-03	8.65e-02	0.05890
Regulation of APC/C activators between G1/S and early anaphase	66	3.72e-03	2.07e-01	0.05890
Assembly of the pre-replicative complex	53	3.90e-03	2.29e-01	0.06050
Hh mutants are degraded by ERAD	46	3.97e-03	2.46e-01	0.06050
Prefoldin mediated transfer of substrate to CCT/TriC	16	4.16e-03	4.14e-01	0.06050
Late Phase of HIV Life Cycle	105	4.16e-03	1.62e-01	0.06050
Platelet calcium homeostasis	17	4.18e-03	-4.01e-01	0.06050
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	43	4.29e-03	2.52e-01	0.06050
p53-Independent DNA Damage Response	43	4.29e-03	2.52e-01	0.06050
p53-Independent G1/S DNA damage checkpoint	43	4.29e-03	2.52e-01	0.06050
Diseases associated with glycosaminoglycan metabolism	15	4.35e-03	-4.25e-01	0.06050
Cap-dependent Translation Initiation	90	4.40e-03	1.74e-01	0.06050
Eukaryotic Translation Initiation	90	4.40e-03	1.74e-01	0.06050
Hemostasis	292	4.57e-03	-9.73e-02	0.06210
Processing of Capped Intron-Containing Pre-mRNA	175	4.92e-03	1.24e-01	0.06540
Orc1 removal from chromatin	55	4.93e-03	2.19e-01	0.06540
Regulation of TP53 Activity through Methylation	16	5.13e-03	4.04e-01	0.06730
Response of EIF2AK4 (GCN2) to amino acid deficiency	72	5.25e-03	1.91e-01	0.06740
Influenza Viral RNA Transcription and Replication	106	5.26e-03	1.57e-01	0.06740
UCH proteinases	69	5.49e-03	1.94e-01	0.06970
NRIF signals cell death from the nucleus	13	6.04e-03	4.40e-01	0.07570
HIV Life Cycle	117	6.17e-03	1.47e-01	0.07660
Cellular responses to stress	425	6.31e-03	7.82e-02	0.07740
Elevation of cytosolic Ca2+ levels	10	6.63e-03	-4.96e-01	0.07940
Branched-chain amino acid catabolism	19	6.67e-03	3.60e-01	0.07940
Autodegradation of Cdh1 by Cdh1:APC/C	52	6.68e-03	2.18e-01	0.07940
Influenza Infection	123	6.79e-03	1.42e-01	0.07990
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	47	6.99e-03	2.28e-01	0.08130
mRNA Splicing - Major Pathway	129	7.05e-03	1.38e-01	0.08130
Switching of origins to a post-replicative state	70	7.23e-03	1.86e-01	0.08250
mRNA Splicing	137	7.35e-03	1.33e-01	0.08300
Neurotransmitter receptors and postsynaptic signal transmission	73	7.49e-03	-1.81e-01	0.08330
Cardiac conduction	40	7.58e-03	-2.44e-01	0.08330
Metabolism of amino acids and derivatives	210	7.68e-03	1.07e-01	0.08330
Cell Cycle Checkpoints	212	7.72e-03	1.07e-01	0.08330
Cytosolic sensors of pathogen-associated DNA	48	7.85e-03	2.22e-01	0.08330
Metabolism of non-coding RNA	43	7.88e-03	2.34e-01	0.08330
snRNP Assembly	43	7.88e-03	2.34e-01	0.08330
Calnexin/calreticulin cycle	23	8.25e-03	3.18e-01	0.08630
Cellular response to starvation	107	8.44e-03	1.48e-01	0.08750
Translation initiation complex formation	46	9.37e-03	2.22e-01	0.09630
Cellular responses to external stimuli	430	9.65e-03	7.37e-02	0.09790
Activation of NMDA receptors and postsynaptic events	43	9.70e-03	-2.28e-01	0.09790
HIV Infection	177	1.01e-02	1.13e-01	0.10100
Opioid Signalling	52	1.04e-02	-2.06e-01	0.10300
Netrin-1 signaling	24	1.05e-02	-3.02e-01	0.10300
RUNX1 regulates transcription of genes involved in differentiation of HSCs	55	1.10e-02	1.98e-01	0.10700
Regulation of PTEN gene transcription	43	1.12e-02	-2.24e-01	0.10700
Integrin signaling	16	1.13e-02	-3.66e-01	0.10700
Platelet Aggregation (Plug Formation)	16	1.13e-02	-3.66e-01	0.10700
ADORA2B mediated anti-inflammatory cytokines production	30	1.14e-02	-2.67e-01	0.10800
Cytokine Signaling in Immune system	411	1.21e-02	-7.30e-02	0.11200
ER Quality Control Compartment (ERQC)	18	1.21e-02	3.42e-01	0.11200
Autodegradation of the E3 ubiquitin ligase COP1	43	1.27e-02	2.20e-01	0.11700
CDK-mediated phosphorylation and removal of Cdc6	58	1.28e-02	1.89e-01	0.11700
PKA-mediated phosphorylation of CREB	11	1.38e-02	-4.29e-01	0.12500
Post NMDA receptor activation events	37	1.39e-02	-2.34e-01	0.12500
Ribosomal scanning and start codon recognition	46	1.41e-02	2.09e-01	0.12600
Constitutive Signaling by AKT1 E17K in Cancer	23	1.42e-02	-2.95e-01	0.12600
Asymmetric localization of PCP proteins	51	1.43e-02	1.99e-01	0.12600
Hh mutants abrogate ligand secretion	48	1.45e-02	2.04e-01	0.12600
Regulation of lipid metabolism by PPARalpha	83	1.52e-02	1.54e-01	0.13200
Interferon gamma signaling	53	1.56e-02	-1.92e-01	0.13400
Signaling by NOTCH3	30	1.58e-02	2.55e-01	0.13500
Regulation of activated PAK-2p34 by proteasome mediated degradation	41	1.61e-02	2.17e-01	0.13500
Cellular response to chemical stress	111	1.61e-02	1.33e-01	0.13500
Formation of the ternary complex, and subsequently, the 43S complex	39	1.62e-02	2.23e-01	0.13500
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	22	1.65e-02	2.95e-01	0.13600
Glycosaminoglycan metabolism	59	1.65e-02	-1.81e-01	0.13600
Degradation of AXIN	46	1.69e-02	2.04e-01	0.13800
DCC mediated attractive signaling	11	1.70e-02	-4.16e-01	0.13800
SCF-beta-TrCP mediated degradation of Emi1	46	1.73e-02	2.03e-01	0.13900
Signaling by NOTCH4	67	1.75e-02	1.68e-01	0.13900
Hedgehog ligand biogenesis	51	1.76e-02	1.92e-01	0.13900
Mitotic G2-G2/M phases	145	1.79e-02	1.14e-01	0.14100
Inactivation of APC/C via direct inhibition of the APC/C complex	16	1.82e-02	3.41e-01	0.14100
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	16	1.82e-02	3.41e-01	0.14100
Interleukin-4 and Interleukin-13 signaling	47	1.82e-02	-1.99e-01	0.14100
RHO GTPases activate PKNs	26	1.85e-02	-2.67e-01	0.14100
Costimulation by the CD28 family	44	1.86e-02	-2.05e-01	0.14100
Cellular response to hypoxia	58	1.88e-02	1.79e-01	0.14200
The role of GTSE1 in G2/M progression after G2 checkpoint	51	1.91e-02	1.90e-01	0.14300
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	18	1.94e-02	3.19e-01	0.14400
Regulation of RUNX3 expression and activity	48	1.95e-02	1.95e-01	0.14500
G2/M Transition	143	1.97e-02	1.13e-01	0.14500
RAS processing	13	2.00e-02	-3.73e-01	0.14700
HDACs deacetylate histones	26	2.13e-02	-2.61e-01	0.15400
G2/M Checkpoints	108	2.13e-02	1.29e-01	0.15400
Heparan sulfate/heparin (HS-GAG) metabolism	19	2.25e-02	-3.02e-01	0.16200
DNA Replication	101	2.28e-02	1.32e-01	0.16200
Ubiquitin-dependent degradation of Cyclin D	43	2.29e-02	2.01e-01	0.16200
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	2.32e-02	-4.15e-01	0.16400
PPARA activates gene expression	81	2.37e-02	1.46e-01	0.16600
Interferon alpha/beta signaling	50	2.41e-02	-1.85e-01	0.16600
ECM proteoglycans	10	2.42e-02	-4.12e-01	0.16600
Deactivation of the beta-catenin transactivating complex	27	2.42e-02	2.51e-01	0.16600
Mitotic Spindle Checkpoint	93	2.42e-02	1.36e-01	0.16600
Nuclear Envelope (NE) Reassembly	56	2.48e-02	1.74e-01	0.16800
PKMTs methylate histone lysines	24	2.53e-02	2.64e-01	0.17100
Regulation of Apoptosis	44	2.66e-02	1.93e-01	0.17800
Synthesis of IP3 and IP4 in the cytosol	16	2.68e-02	-3.20e-01	0.17900
Neuronal System	127	2.83e-02	-1.13e-01	0.18700
Transport of small molecules	322	2.85e-02	7.17e-02	0.18700
Membrane binding and targetting of GAG proteins	11	2.90e-02	3.80e-01	0.18700
Synthesis And Processing Of GAG, GAGPOL Polyproteins	11	2.90e-02	3.80e-01	0.18700
Vpu mediated degradation of CD4	43	2.90e-02	1.93e-01	0.18700
Stabilization of p53	48	2.90e-02	1.82e-01	0.18700
Purine catabolism	10	2.95e-02	-3.98e-01	0.18900
PKA activation	10	3.04e-02	-3.95e-01	0.19400
Synthesis of DNA	94	3.08e-02	1.29e-01	0.19600
ABC transporter disorders	56	3.15e-02	1.66e-01	0.19800
rRNA modification in the nucleus and cytosol	42	3.19e-02	1.92e-01	0.19800
Nucleotide Excision Repair	98	3.20e-02	1.26e-01	0.19800
Formation of TC-NER Pre-Incision Complex	45	3.20e-02	1.85e-01	0.19800
Signaling by FLT3 ITD and TKD mutants	12	3.21e-02	-3.57e-01	0.19800
Cytoprotection by HMOX1	90	3.24e-02	1.31e-01	0.19900
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	30	3.30e-02	-2.25e-01	0.20100
G alpha (s) signalling events	35	3.32e-02	-2.08e-01	0.20200
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	51	3.43e-02	1.72e-01	0.20700
G1/S Transition	106	3.45e-02	1.19e-01	0.20700
Fanconi Anemia Pathway	29	3.52e-02	2.26e-01	0.20900
Ion homeostasis	25	3.52e-02	-2.43e-01	0.20900
Negative regulation of NOTCH4 signaling	47	3.54e-02	1.78e-01	0.20900
CD28 dependent PI3K/Akt signaling	18	3.55e-02	-2.86e-01	0.20900
Activation of BAD and translocation to mitochondria	14	3.82e-02	-3.20e-01	0.22300
AUF1 (hnRNP D0) binds and destabilizes mRNA	45	3.86e-02	1.78e-01	0.22300
Disorders of transmembrane transporters	102	3.88e-02	1.19e-01	0.22300
Asparagine N-linked glycosylation	214	3.88e-02	8.24e-02	0.22300
Dectin-1 mediated noncanonical NF-kB signaling	50	3.89e-02	1.69e-01	0.22300
SCF(Skp2)-mediated degradation of p27/p21	51	3.96e-02	1.67e-01	0.22600
Constitutive Signaling by Aberrant PI3K in Cancer	26	4.07e-02	-2.32e-01	0.23100
Cell Cycle	482	4.09e-02	5.51e-02	0.23100
Mitotic G1 phase and G1/S transition	121	4.14e-02	1.08e-01	0.23300
Signaling by VEGF	71	4.17e-02	-1.40e-01	0.23300
MET promotes cell motility	12	4.20e-02	-3.39e-01	0.23300
G1/S DNA Damage Checkpoints	57	4.20e-02	1.56e-01	0.23300
Negative regulation of the PI3K/AKT network	53	4.26e-02	-1.61e-01	0.23500
Regulation of innate immune responses to cytosolic DNA	11	4.29e-02	3.53e-01	0.23500
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	48	4.48e-02	-1.68e-01	0.24400
Global Genome Nucleotide Excision Repair (GG-NER)	76	4.57e-02	1.33e-01	0.24800
Deadenylation-dependent mRNA decay	49	4.61e-02	1.65e-01	0.24800
Transport of Mature mRNA derived from an Intron-Containing Transcript	45	4.61e-02	1.72e-01	0.24800
GAB1 signalosome	10	4.64e-02	-3.64e-01	0.24800
SARS-CoV-2 Infection	54	4.65e-02	1.57e-01	0.24800
Inflammasomes	16	4.83e-02	2.85e-01	0.25700
Formation of Incision Complex in GG-NER	36	4.86e-02	1.90e-01	0.25700
EML4 and NUDC in mitotic spindle formation	85	4.91e-02	1.24e-01	0.25800
APC/C:Cdc20 mediated degradation of Cyclin B	19	4.94e-02	2.61e-01	0.25800
ABC-family proteins mediated transport	71	4.99e-02	1.35e-01	0.26000
The NLRP3 inflammasome	12	5.02e-02	3.27e-01	0.26000
DNA Damage Bypass	40	5.06e-02	1.79e-01	0.26100
Integration of energy metabolism	56	5.14e-02	-1.51e-01	0.26400
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	10	5.19e-02	-3.55e-01	0.26600
VEGFA-VEGFR2 Pathway	69	5.23e-02	-1.35e-01	0.26600
Chaperonin-mediated protein folding	52	5.28e-02	1.55e-01	0.26700
S Phase	128	5.30e-02	9.94e-02	0.26700
SUMOylation of DNA replication proteins	41	5.31e-02	1.75e-01	0.26700
Vif-mediated degradation of APOBEC3G	42	5.34e-02	1.72e-01	0.26700
PIP3 activates AKT signaling	172	5.36e-02	-8.57e-02	0.26700
Transmission across Chemical Synapses	93	5.38e-02	-1.16e-01	0.26700
Late endosomal microautophagy	21	5.42e-02	2.43e-01	0.26800
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	34	5.46e-02	-1.91e-01	0.26800
Activation of ATR in response to replication stress	29	5.48e-02	2.06e-01	0.26800
Semaphorin interactions	36	5.68e-02	-1.84e-01	0.27600
Transcriptional regulation of white adipocyte differentiation	55	5.68e-02	1.49e-01	0.27600
Cyclin E associated events during G1/S transition	70	5.74e-02	1.32e-01	0.27700
Regulation of PTEN stability and activity	55	5.76e-02	1.48e-01	0.27700
MHC class II antigen presentation	64	5.79e-02	1.37e-01	0.27800
Neurexins and neuroligins	20	5.86e-02	-2.44e-01	0.28000
Activation of BH3-only proteins	25	5.91e-02	-2.18e-01	0.28000
Budding and maturation of HIV virion	21	5.91e-02	2.38e-01	0.28000
Interleukin-37 signaling	16	5.93e-02	-2.72e-01	0.28000
Metalloprotease DUBs	16	5.97e-02	2.72e-01	0.28100
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	81	6.14e-02	1.20e-01	0.28600
Amplification of signal from the kinetochores	81	6.14e-02	1.20e-01	0.28600
NIK–>noncanonical NF-kB signaling	49	6.20e-02	1.54e-01	0.28600
Metal ion SLC transporters	13	6.20e-02	2.99e-01	0.28600
Degradation of beta-catenin by the destruction complex	67	6.32e-02	1.31e-01	0.29000
DAP12 interactions	21	6.34e-02	-2.34e-01	0.29000
Post-translational protein phosphorylation	33	6.35e-02	-1.87e-01	0.29000
Translesion synthesis by POLI	15	6.45e-02	2.76e-01	0.29300
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	6.55e-02	-3.37e-01	0.29300
alpha-linolenic acid (ALA) metabolism	10	6.55e-02	-3.37e-01	0.29300
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	68	6.58e-02	1.29e-01	0.29300
ROS and RNS production in phagocytes	22	6.59e-02	2.27e-01	0.29300
Iron uptake and transport	37	6.60e-02	1.75e-01	0.29300
Cell surface interactions at the vascular wall	56	6.61e-02	-1.42e-01	0.29300
Assembly Of The HIV Virion	13	6.69e-02	2.94e-01	0.29600
Leishmania infection	107	6.74e-02	-1.03e-01	0.29700
CD28 co-stimulation	27	6.77e-02	-2.03e-01	0.29700
Smooth Muscle Contraction	19	6.79e-02	-2.42e-01	0.29700
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	45	6.91e-02	1.57e-01	0.30100
Non-integrin membrane-ECM interactions	12	7.04e-02	-3.02e-01	0.30500
TNF signaling	35	7.06e-02	1.77e-01	0.30500
Cell recruitment (pro-inflammatory response)	15	7.12e-02	2.69e-01	0.30500
Purinergic signaling in leishmaniasis infection	15	7.12e-02	2.69e-01	0.30500
SHC1 events in ERBB2 signaling	10	7.14e-02	-3.29e-01	0.30500
Post-translational protein modification	860	7.16e-02	3.71e-02	0.30500
Regulation of RUNX2 expression and activity	56	7.28e-02	1.39e-01	0.30800
Formation of tubulin folding intermediates by CCT/TriC	13	7.29e-02	2.87e-01	0.30800
VEGFR2 mediated cell proliferation	16	7.36e-02	-2.58e-01	0.31000
Citric acid cycle (TCA cycle)	19	7.41e-02	-2.37e-01	0.31100
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	7.47e-02	2.86e-01	0.31200
Activation of the pre-replicative complex	23	7.51e-02	2.15e-01	0.31300
Sialic acid metabolism	22	7.64e-02	2.18e-01	0.31600
Protein-protein interactions at synapses	31	7.66e-02	-1.84e-01	0.31600
Transcriptional regulation by RUNX1	122	7.69e-02	9.31e-02	0.31600
Resolution of Sister Chromatid Cohesion	90	7.77e-02	1.08e-01	0.31600
Senescence-Associated Secretory Phenotype (SASP)	39	7.78e-02	1.63e-01	0.31600
Pyruvate metabolism and Citric Acid (TCA) cycle	40	7.79e-02	-1.61e-01	0.31600
Pyroptosis	17	7.79e-02	2.47e-01	0.31600
Signaling by Interleukins	256	7.87e-02	-6.43e-02	0.31700
Regulation of insulin secretion	36	7.87e-02	-1.70e-01	0.31700
Signaling by ERBB4	28	7.92e-02	1.92e-01	0.31800
Regulation of IFNA signaling	12	7.98e-02	-2.92e-01	0.31900
Signaling by FLT3 fusion proteins	16	8.03e-02	-2.53e-01	0.31900
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	21	8.04e-02	-2.21e-01	0.31900
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	34	8.05e-02	1.73e-01	0.31900
Signaling by NTRK2 (TRKB)	15	8.09e-02	-2.60e-01	0.31900
Regulation of TNFR1 signaling	30	8.13e-02	1.84e-01	0.32000
Deadenylation of mRNA	22	8.21e-02	2.14e-01	0.32200
Ub-specific processing proteases	130	8.23e-02	8.86e-02	0.32200
Stimuli-sensing channels	35	8.32e-02	1.69e-01	0.32400
SUMO E3 ligases SUMOylate target proteins	130	8.45e-02	8.79e-02	0.32700
Basigin interactions	14	8.46e-02	-2.66e-01	0.32700
Activation of NF-kappaB in B cells	54	8.62e-02	1.35e-01	0.33200
Cargo concentration in the ER	19	8.66e-02	2.27e-01	0.33300
ROS sensing by NFE2L2	47	8.72e-02	1.44e-01	0.33400
Translesion synthesis by REV1	14	8.80e-02	2.63e-01	0.33600
Degradation of GLI1 by the proteasome	50	8.89e-02	1.39e-01	0.33800
Degradation of GLI2 by the proteasome	49	8.98e-02	1.40e-01	0.33900
GLI3 is processed to GLI3R by the proteasome	49	8.98e-02	1.40e-01	0.33900
SUMOylation	135	8.99e-02	8.49e-02	0.33900
Transcriptional regulation by RUNX3	73	9.05e-02	1.15e-01	0.34000
Sulfur amino acid metabolism	15	9.16e-02	-2.52e-01	0.34100
Chondroitin sulfate/dermatan sulfate metabolism	26	9.16e-02	-1.91e-01	0.34100
Immune System	1091	9.20e-02	-3.12e-02	0.34100
Molecules associated with elastic fibres	10	9.24e-02	-3.07e-01	0.34100
G alpha (q) signalling events	70	9.25e-02	-1.17e-01	0.34100
Degradation of DVL	47	9.31e-02	1.42e-01	0.34300
Endosomal Sorting Complex Required For Transport (ESCRT)	24	9.40e-02	1.98e-01	0.34500
Signaling by EGFR	35	9.45e-02	-1.63e-01	0.34600
InlB-mediated entry of Listeria monocytogenes into host cell	11	9.56e-02	2.90e-01	0.34800
p53-Dependent G1 DNA Damage Response	55	9.64e-02	1.30e-01	0.34900
p53-Dependent G1/S DNA damage checkpoint	55	9.64e-02	1.30e-01	0.34900
Regulated Necrosis	41	9.67e-02	1.50e-01	0.34900
DAP12 signaling	19	9.77e-02	-2.20e-01	0.35200
Ephrin signaling	12	9.86e-02	-2.75e-01	0.35200
mRNA Splicing - Minor Pathway	42	9.93e-02	1.47e-01	0.35200
RHOG GTPase cycle	45	9.93e-02	1.42e-01	0.35200
Protein folding	58	9.94e-02	1.25e-01	0.35200
RNA polymerase II transcribes snRNA genes	62	9.95e-02	1.21e-01	0.35200
Polo-like kinase mediated events	16	1.01e-01	2.37e-01	0.35800
RHOB GTPase cycle	40	1.03e-01	-1.49e-01	0.36100
Synthesis of PIPs at the early endosome membrane	11	1.03e-01	2.84e-01	0.36100
RMTs methylate histone arginines	23	1.03e-01	1.96e-01	0.36100
Platelet activation, signaling and aggregation	125	1.03e-01	-8.46e-02	0.36100
TP53 Regulates Transcription of DNA Repair Genes	45	1.04e-01	1.40e-01	0.36300
Regulation of HMOX1 expression and activity	54	1.05e-01	1.28e-01	0.36300
SARS-CoV-1 Infection	41	1.07e-01	1.46e-01	0.37100
Mitotic Prometaphase	146	1.08e-01	7.74e-02	0.37300
Signaling by Receptor Tyrosine Kinases	273	1.09e-01	-5.69e-02	0.37300
Regulation of TP53 Activity through Acetylation	27	1.09e-01	-1.78e-01	0.37400
Nicotinamide salvaging	10	1.10e-01	-2.92e-01	0.37500
NCAM signaling for neurite out-growth	23	1.10e-01	-1.92e-01	0.37500
Cyclin A:Cdk2-associated events at S phase entry	72	1.10e-01	1.09e-01	0.37500
Regulation of TP53 Activity through Phosphorylation	74	1.15e-01	1.06e-01	0.39000
Rev-mediated nuclear export of HIV RNA	31	1.16e-01	1.63e-01	0.39200
Insulin receptor recycling	16	1.16e-01	2.27e-01	0.39200
Carboxyterminal post-translational modifications of tubulin	19	1.17e-01	2.08e-01	0.39300
Nucleobase catabolism	20	1.17e-01	-2.02e-01	0.39300
Generation of second messenger molecules	16	1.18e-01	-2.26e-01	0.39300
Cross-presentation of soluble exogenous antigens (endosomes)	37	1.19e-01	1.48e-01	0.39600
Potential therapeutics for SARS	56	1.19e-01	-1.21e-01	0.39600
Mitochondrial calcium ion transport	13	1.20e-01	2.49e-01	0.39600
MAPK6/MAPK4 signaling	64	1.20e-01	1.12e-01	0.39600
EPHB-mediated forward signaling	25	1.20e-01	-1.80e-01	0.39600
RHOH GTPase cycle	27	1.21e-01	1.72e-01	0.39800
Postmitotic nuclear pore complex (NPC) reformation	25	1.22e-01	1.79e-01	0.39800
mRNA decay by 5’ to 3’ exoribonuclease	14	1.22e-01	2.39e-01	0.39800
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	1.22e-01	-2.30e-01	0.39800
RHO GTPases activate PAKs	13	1.23e-01	-2.47e-01	0.40000
Zinc transporters	10	1.25e-01	2.81e-01	0.40300
CLEC7A (Dectin-1) induces NFAT activation	11	1.25e-01	-2.67e-01	0.40400
Phase II - Conjugation of compounds	42	1.27e-01	1.36e-01	0.40900
Translesion synthesis by POLK	15	1.30e-01	2.26e-01	0.41600
Antigen processing-Cross presentation	71	1.31e-01	1.04e-01	0.41600
Peroxisomal lipid metabolism	20	1.31e-01	-1.95e-01	0.41600
Sealing of the nuclear envelope (NE) by ESCRT-III	16	1.31e-01	2.18e-01	0.41600
Metabolism of nitric oxide: NOS3 activation and regulation	12	1.33e-01	-2.51e-01	0.42000
Transport of the SLBP Dependant Mature mRNA	31	1.33e-01	1.56e-01	0.42000
Cytochrome P450 - arranged by substrate type	14	1.33e-01	-2.32e-01	0.42000
Cellular response to heat stress	75	1.34e-01	1.00e-01	0.42000
Deubiquitination	188	1.34e-01	6.37e-02	0.42100
PCP/CE pathway	70	1.35e-01	1.04e-01	0.42200
Transport of bile salts and organic acids, metal ions and amine compounds	29	1.37e-01	1.60e-01	0.42700
Elastic fibre formation	15	1.38e-01	-2.21e-01	0.43000
DNA Double-Strand Break Repair	106	1.40e-01	8.33e-02	0.43300
Transcriptional Regulation by VENTX	25	1.40e-01	1.71e-01	0.43300
Mitochondrial biogenesis	50	1.44e-01	-1.19e-01	0.44400
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	1.45e-01	-2.66e-01	0.44400
Phase I - Functionalization of compounds	29	1.45e-01	-1.56e-01	0.44400
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	1.45e-01	-2.66e-01	0.44400
BBSome-mediated cargo-targeting to cilium	18	1.47e-01	1.97e-01	0.45000
Glycogen synthesis	11	1.49e-01	2.51e-01	0.45400
Other interleukin signaling	16	1.49e-01	-2.08e-01	0.45400
Effects of PIP2 hydrolysis	18	1.51e-01	-1.95e-01	0.45800
p75NTR signals via NF-kB	11	1.52e-01	2.50e-01	0.45800
HDR through Homologous Recombination (HRR)	54	1.52e-01	1.13e-01	0.45800
NGF-stimulated transcription	25	1.53e-01	-1.65e-01	0.45900
Condensation of Prophase Chromosomes	12	1.53e-01	-2.38e-01	0.45900
Host Interactions of HIV factors	103	1.55e-01	8.14e-02	0.46100
TCF dependent signaling in response to WNT	117	1.55e-01	7.64e-02	0.46100
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	56	1.57e-01	1.10e-01	0.46600
TICAM1, RIP1-mediated IKK complex recruitment	17	1.57e-01	1.98e-01	0.46600
Regulation of BACH1 activity	11	1.58e-01	2.46e-01	0.46600
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	15	1.58e-01	2.11e-01	0.46600
Pexophagy	11	1.59e-01	2.46e-01	0.46700
DDX58/IFIH1-mediated induction of interferon-alpha/beta	56	1.61e-01	1.08e-01	0.47300
Aberrant regulation of mitotic exit in cancer due to RB1 defects	15	1.66e-01	2.07e-01	0.48500
Metabolism of polyamines	46	1.68e-01	1.18e-01	0.48900
Platelet homeostasis	45	1.68e-01	-1.19e-01	0.49000
SUMOylation of immune response proteins	10	1.69e-01	2.51e-01	0.49200
Chaperone Mediated Autophagy	12	1.70e-01	2.29e-01	0.49300
Cytochrome c-mediated apoptotic response	10	1.71e-01	2.50e-01	0.49500
Cyclin A/B1/B2 associated events during G2/M transition	22	1.76e-01	1.67e-01	0.50300
Regulation of KIT signaling	10	1.76e-01	-2.47e-01	0.50300
Interactions of Rev with host cellular proteins	32	1.76e-01	1.38e-01	0.50300
Cleavage of the damaged purine	10	1.77e-01	-2.47e-01	0.50300
Depurination	10	1.77e-01	-2.47e-01	0.50300
Recognition and association of DNA glycosylase with site containing an affected purine	10	1.77e-01	-2.47e-01	0.50300
Suppression of phagosomal maturation	12	1.78e-01	2.25e-01	0.50300
RHOV GTPase cycle	22	1.78e-01	-1.66e-01	0.50300
RHO GTPases Activate Formins	100	1.78e-01	7.82e-02	0.50300
Recognition of DNA damage by PCNA-containing replication complex	25	1.79e-01	1.55e-01	0.50500
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	15	1.81e-01	-1.99e-01	0.50900
Listeria monocytogenes entry into host cells	14	1.82e-01	2.06e-01	0.50900
activated TAK1 mediates p38 MAPK activation	12	1.82e-01	-2.23e-01	0.50900
Association of TriC/CCT with target proteins during biosynthesis	28	1.83e-01	1.45e-01	0.51100
Homology Directed Repair	84	1.84e-01	8.40e-02	0.51200
Transport of the SLBP independent Mature mRNA	30	1.84e-01	1.40e-01	0.51200
Nuclear signaling by ERBB4	14	1.86e-01	2.04e-01	0.51600
Resolution of D-loop Structures through Holliday Junction Intermediates	23	1.87e-01	1.59e-01	0.51800
Retrograde transport at the Trans-Golgi-Network	42	1.88e-01	1.18e-01	0.51800
TRAF6 mediated IRF7 activation	15	1.88e-01	1.96e-01	0.51800
Cholesterol biosynthesis	17	1.89e-01	1.84e-01	0.51900
Response of Mtb to phagocytosis	20	1.90e-01	1.69e-01	0.52100
RNA Polymerase II Transcription Termination	35	1.91e-01	1.28e-01	0.52100
Erythropoietin activates RAS	10	1.92e-01	2.38e-01	0.52100
Inhibition of DNA recombination at telomere	17	1.92e-01	-1.83e-01	0.52100
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	1.92e-01	2.09e-01	0.52100
Translation of Replicase and Assembly of the Replication Transcription Complex	10	1.93e-01	2.38e-01	0.52100
Dual Incision in GG-NER	35	1.94e-01	1.27e-01	0.52300
ER-Phagosome pathway	66	1.94e-01	9.25e-02	0.52300
FOXO-mediated transcription of cell cycle genes	12	1.95e-01	-2.16e-01	0.52300
Hyaluronan metabolism	10	1.96e-01	-2.36e-01	0.52400
Signaling by PDGF	24	1.97e-01	-1.52e-01	0.52600
Triglyceride metabolism	16	1.97e-01	-1.86e-01	0.52600
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	14	1.98e-01	-1.99e-01	0.52700
GPCR ligand binding	71	2.00e-01	-8.82e-02	0.52800
TNFR2 non-canonical NF-kB pathway	65	2.00e-01	9.21e-02	0.52800
Regulation of IFNG signaling	13	2.00e-01	-2.05e-01	0.52800
FCERI mediated Ca+2 mobilization	23	2.02e-01	-1.54e-01	0.53300
Dual incision in TC-NER	55	2.05e-01	9.90e-02	0.53600
Fatty acid metabolism	96	2.05e-01	-7.50e-02	0.53600
Glucagon signaling in metabolic regulation	16	2.05e-01	-1.83e-01	0.53600
Role of phospholipids in phagocytosis	16	2.05e-01	-1.83e-01	0.53600
Glyoxylate metabolism and glycine degradation	19	2.06e-01	1.68e-01	0.53700
Role of LAT2/NTAL/LAB on calcium mobilization	10	2.07e-01	-2.31e-01	0.53700
IRS-related events triggered by IGF1R	21	2.07e-01	-1.59e-01	0.53700
Neddylation	172	2.08e-01	5.60e-02	0.53700
Signaling by MET	39	2.08e-01	-1.17e-01	0.53800
Signaling by SCF-KIT	32	2.09e-01	-1.28e-01	0.53800
Defective pyroptosis	10	2.11e-01	-2.28e-01	0.54300
Plasma lipoprotein clearance	19	2.12e-01	1.65e-01	0.54400
Regulation of RAS by GAPs	55	2.14e-01	9.71e-02	0.54600
Regulation of HSF1-mediated heat shock response	62	2.14e-01	9.14e-02	0.54600
Regulation of ornithine decarboxylase (ODC)	42	2.15e-01	1.11e-01	0.54900
G-protein beta:gamma signalling	18	2.16e-01	-1.68e-01	0.54900
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	20	2.17e-01	1.60e-01	0.55000
Glutathione conjugation	20	2.18e-01	1.59e-01	0.55100
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14	2.20e-01	-1.89e-01	0.55500
Diseases associated with glycosylation precursor biosynthesis	18	2.21e-01	1.67e-01	0.55600
Synthesis of glycosylphosphatidylinositol (GPI)	14	2.22e-01	-1.89e-01	0.55600
Termination of translesion DNA synthesis	28	2.22e-01	1.33e-01	0.55600
HSF1 activation	21	2.23e-01	1.54e-01	0.55600
Infectious disease	507	2.23e-01	3.21e-02	0.55600
Ion channel transport	74	2.24e-01	8.19e-02	0.55800
Transcription of the HIV genome	50	2.25e-01	9.92e-02	0.56000
Factors involved in megakaryocyte development and platelet production	83	2.26e-01	-7.71e-02	0.56000
Pre-NOTCH Transcription and Translation	26	2.27e-01	1.37e-01	0.56100
Innate Immune System	582	2.29e-01	-2.97e-02	0.56600
NEP/NS2 Interacts with the Cellular Export Machinery	28	2.31e-01	1.31e-01	0.57000
Glycogen storage diseases	10	2.33e-01	2.18e-01	0.57200
Signaling by NTRK1 (TRKA)	79	2.33e-01	-7.78e-02	0.57200
ZBP1(DAI) mediated induction of type I IFNs	15	2.35e-01	1.77e-01	0.57400
RHOBTB1 GTPase cycle	18	2.36e-01	1.61e-01	0.57600
LDL clearance	12	2.37e-01	1.97e-01	0.57600
Collagen formation	19	2.37e-01	-1.57e-01	0.57600
Arachidonic acid metabolism	21	2.38e-01	-1.49e-01	0.57700
DARPP-32 events	18	2.39e-01	-1.61e-01	0.57800
RNA Polymerase II Pre-transcription Events	60	2.41e-01	8.76e-02	0.58300
Degradation of the extracellular matrix	26	2.43e-01	-1.32e-01	0.58500
Export of Viral Ribonucleoproteins from Nucleus	29	2.45e-01	1.25e-01	0.59100
Metabolism of carbohydrates	172	2.47e-01	-5.14e-02	0.59300
Hedgehog ‘on’ state	61	2.47e-01	8.58e-02	0.59300
TRAF3-dependent IRF activation pathway	13	2.48e-01	1.85e-01	0.59300
ERKs are inactivated	11	2.49e-01	2.01e-01	0.59400
Signaling by NOTCH	128	2.50e-01	5.92e-02	0.59400
IGF1R signaling cascade	22	2.53e-01	-1.41e-01	0.59800
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	22	2.53e-01	-1.41e-01	0.59800
HDMs demethylate histones	15	2.53e-01	-1.71e-01	0.59800
Rap1 signalling	11	2.53e-01	-1.99e-01	0.59800
Nephrin family interactions	14	2.54e-01	-1.76e-01	0.59900
Energy dependent regulation of mTOR by LKB1-AMPK	21	2.56e-01	-1.43e-01	0.60200
FLT3 Signaling	32	2.56e-01	-1.16e-01	0.60200
Signalling to RAS	12	2.59e-01	-1.88e-01	0.60800
RHOD GTPase cycle	33	2.62e-01	1.13e-01	0.61100
Termination of O-glycan biosynthesis	10	2.62e-01	2.05e-01	0.61100
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	78	2.65e-01	7.32e-02	0.61600
Resolution of D-Loop Structures	24	2.69e-01	1.30e-01	0.62500
Class A/1 (Rhodopsin-like receptors)	44	2.70e-01	-9.63e-02	0.62500
Diseases of programmed cell death	36	2.70e-01	-1.06e-01	0.62500
Depolymerisation of the Nuclear Lamina	11	2.72e-01	-1.91e-01	0.62900
Nuclear Envelope Breakdown	45	2.73e-01	9.45e-02	0.62900
Neutrophil degranulation	288	2.74e-01	-3.78e-02	0.62900
Mitochondrial iron-sulfur cluster biogenesis	10	2.76e-01	1.99e-01	0.63400
Signaling by ERBB2 in Cancer	11	2.78e-01	-1.89e-01	0.63800
Signaling by NTRKs	86	2.79e-01	-6.77e-02	0.63800
Synthesis of very long-chain fatty acyl-CoAs	12	2.80e-01	-1.80e-01	0.64000
Hedgehog ‘off’ state	74	2.82e-01	7.25e-02	0.64200
RHOC GTPase cycle	45	2.83e-01	-9.25e-02	0.64400
Beta-catenin independent WNT signaling	99	2.84e-01	6.25e-02	0.64400
Regulation of cholesterol biosynthesis by SREBP (SREBF)	45	2.86e-01	9.20e-02	0.64800
HCMV Late Events	47	2.88e-01	8.97e-02	0.64800
RUNX3 regulates NOTCH signaling	11	2.89e-01	1.85e-01	0.64800
Interferon Signaling	136	2.90e-01	-5.27e-02	0.64800
SLC-mediated transmembrane transport	90	2.90e-01	6.46e-02	0.64800
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	15	2.91e-01	-1.58e-01	0.64800
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	15	2.91e-01	-1.58e-01	0.64800
G alpha (z) signalling events	22	2.91e-01	-1.30e-01	0.64800
Transport of Mature Transcript to Cytoplasm	54	2.92e-01	8.31e-02	0.64800
COPII-mediated vesicle transport	47	2.92e-01	8.90e-02	0.64800
MicroRNA (miRNA) biogenesis	17	2.92e-01	-1.48e-01	0.64800
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	2.94e-01	1.92e-01	0.64900
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	41	2.96e-01	9.45e-02	0.64900
Constitutive Signaling by NOTCH1 PEST Domain Mutants	41	2.96e-01	9.45e-02	0.64900
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	41	2.96e-01	9.45e-02	0.64900
Signaling by NOTCH1 PEST Domain Mutants in Cancer	41	2.96e-01	9.45e-02	0.64900
Signaling by NOTCH1 in Cancer	41	2.96e-01	9.45e-02	0.64900
Gap junction trafficking and regulation	10	2.96e-01	-1.91e-01	0.64900
Regulation of PLK1 Activity at G2/M Transition	63	2.98e-01	7.59e-02	0.65200
Diseases associated with O-glycosylation of proteins	20	2.99e-01	1.34e-01	0.65200
Collagen biosynthesis and modifying enzymes	13	3.00e-01	-1.66e-01	0.65200
Synthesis of substrates in N-glycan biosythesis	43	3.00e-01	9.14e-02	0.65200
FCERI mediated NF-kB activation	61	3.00e-01	7.68e-02	0.65200
Signaling by NOTCH1	51	3.03e-01	8.34e-02	0.65400
Sphingolipid de novo biosynthesis	18	3.04e-01	1.40e-01	0.65400
Interconversion of nucleotide di- and triphosphates	21	3.04e-01	1.30e-01	0.65400
Translation of structural proteins	26	3.04e-01	1.17e-01	0.65400
FLT3 signaling in disease	24	3.05e-01	-1.21e-01	0.65400
Sema3A PAK dependent Axon repulsion	11	3.08e-01	-1.77e-01	0.66100
KSRP (KHSRP) binds and destabilizes mRNA	14	3.09e-01	-1.57e-01	0.66100
The role of Nef in HIV-1 replication and disease pathogenesis	19	3.09e-01	-1.35e-01	0.66100
Detoxification of Reactive Oxygen Species	22	3.10e-01	1.25e-01	0.66100
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	3.12e-01	1.69e-01	0.66300
MTOR signalling	32	3.12e-01	-1.03e-01	0.66300
Ion transport by P-type ATPases	26	3.13e-01	-1.14e-01	0.66400
BMAL1:CLOCK,NPAS2 activates circadian gene expression	14	3.14e-01	-1.55e-01	0.66500
Cilium Assembly	134	3.15e-01	5.05e-02	0.66500
Nuclear import of Rev protein	29	3.15e-01	1.08e-01	0.66500
Negative regulation of NMDA receptor-mediated neuronal transmission	11	3.17e-01	-1.74e-01	0.66800
Processing of Capped Intronless Pre-mRNA	21	3.18e-01	1.26e-01	0.66800
Fcgamma receptor (FCGR) dependent phagocytosis	61	3.19e-01	-7.39e-02	0.66800
Aquaporin-mediated transport	19	3.19e-01	-1.32e-01	0.66800
RHO GTPases Activate WASPs and WAVEs	28	3.21e-01	-1.09e-01	0.66900
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	3.21e-01	-1.43e-01	0.66900
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	14	3.22e-01	-1.53e-01	0.66900
Extra-nuclear estrogen signaling	46	3.22e-01	-8.44e-02	0.66900
IRS-mediated signalling	20	3.23e-01	-1.28e-01	0.66900
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	23	3.23e-01	-1.19e-01	0.66900
RAC3 GTPase cycle	55	3.26e-01	7.66e-02	0.67100
Interleukin-6 family signaling	13	3.27e-01	-1.57e-01	0.67100
Gene expression (Transcription)	958	3.27e-01	1.92e-02	0.67100
Vpr-mediated nuclear import of PICs	30	3.28e-01	1.03e-01	0.67100
Signaling by WNT	168	3.29e-01	4.39e-02	0.67100
VxPx cargo-targeting to cilium	15	3.29e-01	1.46e-01	0.67100
Oncogene Induced Senescence	27	3.29e-01	1.09e-01	0.67100
Negative regulators of DDX58/IFIH1 signaling	33	3.29e-01	9.83e-02	0.67100
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	3.29e-01	-1.11e-01	0.67100
Cargo recognition for clathrin-mediated endocytosis	64	3.31e-01	7.04e-02	0.67200
tRNA processing in the nucleus	50	3.31e-01	7.96e-02	0.67200
Glycerophospholipid biosynthesis	69	3.37e-01	-6.69e-02	0.68300
Axon guidance	283	3.37e-01	3.34e-02	0.68300
Cell-Cell communication	44	3.39e-01	-8.34e-02	0.68500
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	14	3.40e-01	-1.47e-01	0.68500
GPVI-mediated activation cascade	23	3.41e-01	-1.15e-01	0.68700
Sema4D in semaphorin signaling	13	3.43e-01	-1.52e-01	0.68700
NOD1/2 Signaling Pathway	22	3.43e-01	-1.17e-01	0.68700
Activation of gene expression by SREBF (SREBP)	33	3.45e-01	9.51e-02	0.69000
Diseases of signal transduction by growth factor receptors and second messengers	261	3.46e-01	-3.41e-02	0.69000
Toll Like Receptor 3 (TLR3) Cascade	70	3.46e-01	6.53e-02	0.69000
EGR2 and SOX10-mediated initiation of Schwann cell myelination	12	3.47e-01	-1.57e-01	0.69000
SUMOylation of SUMOylation proteins	30	3.51e-01	9.85e-02	0.69500
Vitamin B5 (pantothenate) metabolism	11	3.51e-01	-1.62e-01	0.69500
Glycolysis	54	3.53e-01	7.32e-02	0.69500
Death Receptor Signalling	88	3.53e-01	5.74e-02	0.69500
Apoptotic cleavage of cellular proteins	24	3.54e-01	-1.09e-01	0.69500
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	65	3.55e-01	-6.65e-02	0.69500
Toll Like Receptor 2 (TLR2) Cascade	65	3.55e-01	-6.65e-02	0.69500
Toll Like Receptor TLR1:TLR2 Cascade	65	3.55e-01	-6.65e-02	0.69500
Toll Like Receptor TLR6:TLR2 Cascade	65	3.55e-01	-6.65e-02	0.69500
Nuclear Pore Complex (NPC) Disassembly	32	3.56e-01	9.45e-02	0.69500
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	26	3.56e-01	1.05e-01	0.69500
Regulation of Glucokinase by Glucokinase Regulatory Protein	26	3.56e-01	1.05e-01	0.69500
Signaling by TGFB family members	71	3.60e-01	-6.29e-02	0.70100
RND2 GTPase cycle	32	3.61e-01	-9.34e-02	0.70200
Sema4D induced cell migration and growth-cone collapse	11	3.64e-01	-1.58e-01	0.70600
Cell death signalling via NRAGE, NRIF and NADE	40	3.64e-01	8.30e-02	0.70600
Processing of DNA double-strand break ends	52	3.66e-01	7.25e-02	0.70700
Signaling by Erythropoietin	19	3.66e-01	1.20e-01	0.70700
Downstream signaling events of B Cell Receptor (BCR)	67	3.68e-01	6.37e-02	0.71000
Infection with Mycobacterium tuberculosis	22	3.71e-01	1.10e-01	0.71200
RAB geranylgeranylation	39	3.71e-01	8.29e-02	0.71200
Polymerase switching on the C-strand of the telomere	20	3.72e-01	-1.15e-01	0.71200
Plasma lipoprotein assembly, remodeling, and clearance	33	3.73e-01	8.98e-02	0.71200
RIP-mediated NFkB activation via ZBP1	12	3.73e-01	1.49e-01	0.71200
Gastrin-CREB signalling pathway via PKC and MAPK	11	3.75e-01	-1.54e-01	0.71500
L1CAM interactions	39	3.75e-01	-8.21e-02	0.71500
Nuclear Events (kinase and transcription factor activation)	42	3.77e-01	-7.89e-02	0.71600
MAP3K8 (TPL2)-dependent MAPK1/3 activation	13	3.78e-01	1.41e-01	0.71600
Spry regulation of FGF signaling	15	3.78e-01	1.31e-01	0.71600
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	15	3.80e-01	1.31e-01	0.71600
Disorders of Developmental Biology	10	3.81e-01	-1.60e-01	0.71600
Disorders of Nervous System Development	10	3.81e-01	-1.60e-01	0.71600
Loss of function of MECP2 in Rett syndrome	10	3.81e-01	-1.60e-01	0.71600
Pervasive developmental disorders	10	3.81e-01	-1.60e-01	0.71600
p75 NTR receptor-mediated signalling	54	3.83e-01	6.88e-02	0.71700
Interleukin-1 signaling	74	3.83e-01	5.88e-02	0.71700
SUMOylation of chromatin organization proteins	47	3.84e-01	-7.35e-02	0.71800
Mitochondrial protein import	42	3.87e-01	-7.73e-02	0.72200
Signaling by KIT in disease	16	3.88e-01	-1.25e-01	0.72200
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	3.88e-01	-1.25e-01	0.72200
Developmental Biology	438	3.89e-01	2.43e-02	0.72300
Regulation of mRNA stability by proteins that bind AU-rich elements	73	3.91e-01	5.82e-02	0.72300
Negative regulation of FLT3	13	3.92e-01	1.37e-01	0.72300
Interactions of Vpr with host cellular proteins	31	3.92e-01	8.90e-02	0.72300
Metabolism of steroid hormones	13	3.92e-01	-1.37e-01	0.72300
Unwinding of DNA	10	3.95e-01	1.55e-01	0.72800
Selective autophagy	50	3.96e-01	-6.94e-02	0.72900
Glycogen metabolism	17	3.97e-01	1.19e-01	0.73000
CTLA4 inhibitory signaling	15	3.99e-01	-1.26e-01	0.73100
RNA Polymerase I Transcription Initiation	38	3.99e-01	-7.92e-02	0.73100
COPI-independent Golgi-to-ER retrograde traffic	28	4.00e-01	-9.19e-02	0.73200
Apoptotic factor-mediated response	15	4.02e-01	1.25e-01	0.73300
RNA Polymerase I Promoter Escape	25	4.02e-01	9.69e-02	0.73300
Nonhomologous End-Joining (NHEJ)	27	4.03e-01	9.30e-02	0.73300
Gluconeogenesis	24	4.04e-01	-9.86e-02	0.73300
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	4.05e-01	-1.34e-01	0.73400
IKK complex recruitment mediated by RIP1	17	4.06e-01	1.16e-01	0.73500
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	13	4.10e-01	1.32e-01	0.73700
Signaling by Ligand-Responsive EGFR Variants in Cancer	13	4.10e-01	1.32e-01	0.73700
Transcriptional regulation of granulopoiesis	24	4.10e-01	-9.71e-02	0.73700
Removal of the Flap Intermediate	12	4.11e-01	1.37e-01	0.73700
Signaling by Hedgehog	97	4.14e-01	4.82e-02	0.73700
Protein localization	113	4.14e-01	-4.46e-02	0.73700
Nicotinate metabolism	16	4.15e-01	-1.18e-01	0.73700
Downstream signaling of activated FGFR1	11	4.16e-01	-1.42e-01	0.73700
Downstream signaling of activated FGFR2	11	4.16e-01	-1.42e-01	0.73700
Downstream signaling of activated FGFR3	11	4.16e-01	-1.42e-01	0.73700
Downstream signaling of activated FGFR4	11	4.16e-01	-1.42e-01	0.73700
FCGR3A-mediated phagocytosis	41	4.16e-01	-7.35e-02	0.73700
Leishmania phagocytosis	41	4.16e-01	-7.35e-02	0.73700
Parasite infection	41	4.16e-01	-7.35e-02	0.73700
Telomere C-strand (Lagging Strand) Synthesis	27	4.17e-01	-9.03e-02	0.73800
Mitotic Prophase	69	4.18e-01	5.65e-02	0.73800
Formation of the beta-catenin:TCF transactivating complex	24	4.20e-01	9.52e-02	0.73800
N-glycan antennae elongation in the medial/trans-Golgi	18	4.20e-01	-1.10e-01	0.73800
Apoptotic execution phase	32	4.21e-01	-8.22e-02	0.73800
AKT phosphorylates targets in the cytosol	13	4.23e-01	-1.28e-01	0.73800
Response to elevated platelet cytosolic Ca2+	50	4.23e-01	-6.56e-02	0.73800
Class B/2 (Secretin family receptors)	25	4.24e-01	-9.25e-02	0.73800
Nervous system development	294	4.25e-01	2.73e-02	0.73800
Mismatch Repair	13	4.25e-01	1.28e-01	0.73800
Downstream signal transduction	20	4.26e-01	-1.03e-01	0.73800
Rab regulation of trafficking	85	4.26e-01	-5.01e-02	0.73800
MAPK family signaling cascades	176	4.26e-01	-3.49e-02	0.73800
tRNA processing	82	4.26e-01	5.09e-02	0.73800
E2F mediated regulation of DNA replication	12	4.26e-01	-1.33e-01	0.73800
Interleukin-7 signaling	14	4.31e-01	-1.22e-01	0.74500
EPH-ephrin mediated repulsion of cells	24	4.34e-01	9.24e-02	0.74900
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	4.35e-01	1.30e-01	0.75000
RHOQ GTPase cycle	36	4.36e-01	7.50e-02	0.75100
RHOU GTPase cycle	24	4.37e-01	-9.17e-02	0.75100
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	4.40e-01	1.24e-01	0.75400
Resolution of Abasic Sites (AP sites)	31	4.41e-01	8.01e-02	0.75400
RND3 GTPase cycle	28	4.41e-01	-8.42e-02	0.75400
Metabolism of water-soluble vitamins and cofactors	76	4.42e-01	-5.11e-02	0.75400
Cargo trafficking to the periciliary membrane	38	4.42e-01	7.21e-02	0.75400
Josephin domain DUBs	11	4.43e-01	1.34e-01	0.75500
Antiviral mechanism by IFN-stimulated genes	73	4.44e-01	5.19e-02	0.75500
Assembly and cell surface presentation of NMDA receptors	12	4.45e-01	-1.27e-01	0.75500
Signaling by BMP	13	4.48e-01	-1.22e-01	0.75900
Attenuation phase	19	4.48e-01	1.01e-01	0.75900
RHOA GTPase cycle	86	4.49e-01	-4.73e-02	0.75900
ADP signalling through P2Y purinoceptor 12	10	4.50e-01	1.38e-01	0.75900
Striated Muscle Contraction	10	4.52e-01	-1.37e-01	0.76100
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	19	4.52e-01	-9.96e-02	0.76100
Signaling by NTRK3 (TRKC)	10	4.54e-01	-1.37e-01	0.76200
Gamma carboxylation, hypusine formation and arylsulfatase activation	21	4.57e-01	9.39e-02	0.76600
COPI-dependent Golgi-to-ER retrograde traffic	63	4.58e-01	5.42e-02	0.76700
PRC2 methylates histones and DNA	11	4.58e-01	-1.29e-01	0.76700
Initiation of Nuclear Envelope (NE) Reformation	17	4.59e-01	1.04e-01	0.76700
Vasopressin regulates renal water homeostasis via Aquaporins	18	4.60e-01	-1.01e-01	0.76700
Signaling by FGFR1 in disease	23	4.62e-01	-8.86e-02	0.77000
G beta:gamma signalling through PLC beta	10	4.64e-01	-1.34e-01	0.77100
Presynaptic function of Kainate receptors	10	4.64e-01	-1.34e-01	0.77100
Signaling by ERBB2 KD Mutants	10	4.69e-01	-1.32e-01	0.77700
AURKA Activation by TPX2	51	4.70e-01	5.86e-02	0.77800
Triglyceride catabolism	11	4.70e-01	-1.26e-01	0.77800
VEGFR2 mediated vascular permeability	21	4.72e-01	-9.07e-02	0.77900
RHO GTPases activate CIT	14	4.73e-01	-1.11e-01	0.77900
Metabolism of folate and pterines	11	4.73e-01	-1.25e-01	0.77900
Condensation of Prometaphase Chromosomes	10	4.74e-01	-1.31e-01	0.77900
Adaptive Immune System	451	4.74e-01	-1.99e-02	0.77900
Long-term potentiation	10	4.75e-01	-1.30e-01	0.77900
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	4.76e-01	-1.06e-01	0.77900
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	4.77e-01	-1.19e-01	0.77900
Signalling to ERKs	25	4.77e-01	-8.22e-02	0.77900
ER to Golgi Anterograde Transport	101	4.78e-01	4.10e-02	0.77900
Antigen processing: Ubiquitination & Proteasome degradation	226	4.80e-01	2.74e-02	0.78200
FOXO-mediated transcription	45	4.84e-01	-6.04e-02	0.78600
Phosphorylation of the APC/C	15	4.84e-01	1.04e-01	0.78600
Nucleobase biosynthesis	12	4.85e-01	1.16e-01	0.78600
SLC transporter disorders	46	4.87e-01	5.94e-02	0.78700
HIV Transcription Initiation	37	4.90e-01	6.56e-02	0.78700
RNA Polymerase II HIV Promoter Escape	37	4.90e-01	6.56e-02	0.78700
RNA Polymerase II Promoter Escape	37	4.90e-01	6.56e-02	0.78700
RNA Polymerase II Transcription Initiation	37	4.90e-01	6.56e-02	0.78700
RNA Polymerase II Transcription Initiation And Promoter Clearance	37	4.90e-01	6.56e-02	0.78700
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	37	4.90e-01	6.56e-02	0.78700
MAPK1/MAPK3 signaling	153	4.93e-01	-3.23e-02	0.78800
RIPK1-mediated regulated necrosis	24	4.93e-01	8.09e-02	0.78800
Regulation of necroptotic cell death	24	4.93e-01	8.09e-02	0.78800
Signaling by Nuclear Receptors	142	4.95e-01	-3.33e-02	0.78800
Downregulation of SMAD2/3:SMAD4 transcriptional activity	21	4.95e-01	8.60e-02	0.78800
Transcription of E2F targets under negative control by DREAM complex	17	4.96e-01	9.54e-02	0.78800
Deposition of new CENPA-containing nucleosomes at the centromere	20	4.96e-01	8.79e-02	0.78800
Nucleosome assembly	20	4.96e-01	8.79e-02	0.78800
HDR through Single Strand Annealing (SSA)	32	5.00e-01	6.90e-02	0.78900
NRAGE signals death through JNK	25	5.01e-01	-7.79e-02	0.78900
Homologous DNA Pairing and Strand Exchange	34	5.01e-01	6.67e-02	0.78900
Formation of RNA Pol II elongation complex	43	5.01e-01	5.93e-02	0.78900
RNA Polymerase II Transcription Elongation	43	5.01e-01	5.93e-02	0.78900
HSF1-dependent transactivation	25	5.02e-01	7.77e-02	0.78900
Meiotic recombination	19	5.04e-01	8.87e-02	0.78900
tRNA Aminoacylation	21	5.04e-01	-8.42e-02	0.78900
Transcriptional regulation by RUNX2	82	5.05e-01	4.27e-02	0.78900
Intrinsic Pathway for Apoptosis	44	5.08e-01	-5.78e-02	0.78900
MyD88-independent TLR4 cascade	70	5.09e-01	4.57e-02	0.78900
TRIF(TICAM1)-mediated TLR4 signaling	70	5.09e-01	4.57e-02	0.78900
Heme biosynthesis	10	5.14e-01	1.19e-01	0.78900
Telomere Maintenance	53	5.15e-01	-5.18e-02	0.78900
ISG15 antiviral mechanism	67	5.16e-01	4.60e-02	0.78900
RET signaling	22	5.17e-01	-7.99e-02	0.78900
Negative regulation of FGFR1 signaling	17	5.17e-01	9.09e-02	0.78900
Negative regulation of FGFR2 signaling	17	5.17e-01	9.09e-02	0.78900
Negative regulation of FGFR3 signaling	17	5.17e-01	9.09e-02	0.78900
Negative regulation of FGFR4 signaling	17	5.17e-01	9.09e-02	0.78900
Gap-filling DNA repair synthesis and ligation in TC-NER	54	5.17e-01	5.10e-02	0.78900
Complex I biogenesis	38	5.18e-01	6.06e-02	0.78900
Signaling by Insulin receptor	40	5.20e-01	5.89e-02	0.78900
Class I MHC mediated antigen processing & presentation	267	5.20e-01	2.30e-02	0.78900
S33 mutants of beta-catenin aren’t phosphorylated	13	5.21e-01	1.03e-01	0.78900
S37 mutants of beta-catenin aren’t phosphorylated	13	5.21e-01	1.03e-01	0.78900
S45 mutants of beta-catenin aren’t phosphorylated	13	5.21e-01	1.03e-01	0.78900
Signaling by CTNNB1 phospho-site mutants	13	5.21e-01	1.03e-01	0.78900
Signaling by GSK3beta mutants	13	5.21e-01	1.03e-01	0.78900
T41 mutants of beta-catenin aren’t phosphorylated	13	5.21e-01	1.03e-01	0.78900
RHOF GTPase cycle	23	5.21e-01	7.73e-02	0.78900
Signaling by RAF1 mutants	25	5.21e-01	-7.41e-02	0.78900
Signaling by CSF3 (G-CSF)	25	5.22e-01	-7.40e-02	0.78900
Pyruvate metabolism	19	5.22e-01	-8.49e-02	0.78900
Signaling by Retinoic Acid	17	5.23e-01	8.95e-02	0.78900
Diseases of DNA repair	10	5.24e-01	1.16e-01	0.78900
Signaling by Non-Receptor Tyrosine Kinases	33	5.24e-01	6.42e-02	0.78900
Signaling by PTK6	33	5.24e-01	6.42e-02	0.78900
Intraflagellar transport	30	5.25e-01	6.72e-02	0.78900
Caspase activation via Death Receptors in the presence of ligand	10	5.26e-01	1.16e-01	0.78900
Autophagy	95	5.27e-01	3.77e-02	0.78900
Metabolic disorders of biological oxidation enzymes	14	5.27e-01	9.76e-02	0.78900
Presynaptic phase of homologous DNA pairing and strand exchange	31	5.27e-01	6.57e-02	0.78900
Maturation of nucleoprotein	10	5.28e-01	-1.15e-01	0.78900
SUMOylation of DNA damage response and repair proteins	65	5.28e-01	4.53e-02	0.78900
DNA Double Strand Break Response	33	5.29e-01	6.34e-02	0.78900
Fatty acyl-CoA biosynthesis	22	5.29e-01	-7.75e-02	0.78900
mRNA Capping	25	5.33e-01	7.20e-02	0.79300
Mitochondrial Fatty Acid Beta-Oxidation	24	5.35e-01	7.31e-02	0.79300
Formation of HIV elongation complex in the absence of HIV Tat	31	5.37e-01	6.42e-02	0.79300
Formation of HIV-1 elongation complex containing HIV-1 Tat	31	5.37e-01	6.42e-02	0.79300
HIV Transcription Elongation	31	5.37e-01	6.42e-02	0.79300
Tat-mediated elongation of the HIV-1 transcript	31	5.37e-01	6.42e-02	0.79300
Anchoring of the basal body to the plasma membrane	70	5.37e-01	4.27e-02	0.79300
Dopamine Neurotransmitter Release Cycle	10	5.39e-01	-1.12e-01	0.79400
Pre-NOTCH Processing in Golgi	15	5.40e-01	-9.15e-02	0.79400
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	32	5.40e-01	6.27e-02	0.79400
Class I peroxisomal membrane protein import	18	5.40e-01	-8.34e-02	0.79400
Transport of vitamins, nucleosides, and related molecules	21	5.42e-01	7.68e-02	0.79600
Clathrin-mediated endocytosis	89	5.44e-01	3.73e-02	0.79600
Platelet degranulation	46	5.45e-01	-5.17e-02	0.79600
ESR-mediated signaling	106	5.45e-01	-3.42e-02	0.79600
RNA Polymerase II Transcription	856	5.45e-01	1.25e-02	0.79600
TBC/RABGAPs	39	5.47e-01	-5.59e-02	0.79700
Regulation of actin dynamics for phagocytic cup formation	43	5.48e-01	-5.30e-02	0.79800
Membrane Trafficking	419	5.50e-01	1.73e-02	0.79900
Sensory Perception	63	5.51e-01	-4.35e-02	0.79900
RUNX2 regulates bone development	17	5.51e-01	-8.36e-02	0.79900
Processive synthesis on the C-strand of the telomere	17	5.52e-01	-8.34e-02	0.79900
Amino acids regulate mTORC1	35	5.53e-01	5.80e-02	0.80000
SUMOylation of ubiquitinylation proteins	35	5.56e-01	5.76e-02	0.80200
Transferrin endocytosis and recycling	18	5.56e-01	8.01e-02	0.80300
Golgi Cisternae Pericentriolar Stack Reorganization	13	5.59e-01	9.37e-02	0.80300
Loss of Nlp from mitotic centrosomes	48	5.60e-01	4.87e-02	0.80300
Loss of proteins required for interphase microtubule organization from the centrosome	48	5.60e-01	4.87e-02	0.80300
PI3K Cascade	18	5.60e-01	-7.95e-02	0.80300
O-linked glycosylation of mucins	26	5.63e-01	-6.57e-02	0.80600
Transcriptional regulation by small RNAs	40	5.64e-01	5.28e-02	0.80700
G1/S-Specific Transcription	24	5.64e-01	6.80e-02	0.80700
MAP2K and MAPK activation	22	5.66e-01	-7.07e-02	0.80700
Signaling by high-kinase activity BRAF mutants	22	5.66e-01	-7.07e-02	0.80700
The citric acid (TCA) cycle and respiratory electron transport	109	5.66e-01	-3.19e-02	0.80700
Glycosphingolipid metabolism	25	5.69e-01	-6.59e-02	0.80900
Miscellaneous transport and binding events	14	5.70e-01	-8.78e-02	0.80900
COPI-mediated anterograde transport	67	5.76e-01	3.96e-02	0.81800
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	20	5.78e-01	7.20e-02	0.81900
ATF4 activates genes in response to endoplasmic reticulum stress	22	5.80e-01	-6.83e-02	0.82100
RHO GTPases Activate NADPH Oxidases	14	5.82e-01	-8.51e-02	0.82200
Heme signaling	25	5.83e-01	-6.35e-02	0.82300
Regulation of TP53 Degradation	33	5.84e-01	5.51e-02	0.82400
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	16	5.85e-01	7.89e-02	0.82400
SUMOylation of transcription factors	13	5.86e-01	8.73e-02	0.82400
Gene Silencing by RNA	54	5.90e-01	4.25e-02	0.82800
NoRC negatively regulates rRNA expression	39	5.90e-01	4.99e-02	0.82800
Amino acid transport across the plasma membrane	16	5.94e-01	-7.70e-02	0.83300
Unfolded Protein Response (UPR)	67	5.96e-01	3.75e-02	0.83500
Growth hormone receptor signaling	17	5.97e-01	-7.40e-02	0.83500
Metabolism of vitamins and cofactors	105	6.01e-01	-2.97e-02	0.83900
HCMV Early Events	48	6.02e-01	-4.36e-02	0.83900
Glutamate Neurotransmitter Release Cycle	11	6.03e-01	9.07e-02	0.83900
Meiotic synapsis	22	6.04e-01	-6.38e-02	0.84000
Toll Like Receptor 4 (TLR4) Cascade	87	6.05e-01	-3.22e-02	0.84000
Interleukin-2 family signaling	28	6.06e-01	-5.64e-02	0.84000
TNFR1-induced proapoptotic signaling	12	6.06e-01	8.60e-02	0.84000
Toll-like Receptor Cascades	97	6.07e-01	-3.03e-02	0.84000
Transport of Ribonucleoproteins into the Host Nucleus	28	6.11e-01	5.56e-02	0.84500
DNA strand elongation	27	6.12e-01	5.64e-02	0.84600
Synthesis of PC	21	6.13e-01	6.37e-02	0.84600
Phospholipid metabolism	127	6.14e-01	-2.60e-02	0.84600
Intra-Golgi and retrograde Golgi-to-ER traffic	151	6.16e-01	2.38e-02	0.84600
Signaling by WNT in cancer	23	6.17e-01	-6.03e-02	0.84600
Transport of Mature mRNAs Derived from Intronless Transcripts	38	6.18e-01	4.69e-02	0.84600
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	6.19e-01	-5.34e-02	0.84600
Signaling by RAS mutants	29	6.19e-01	-5.34e-02	0.84600
Signaling by moderate kinase activity BRAF mutants	29	6.19e-01	-5.34e-02	0.84600
Signaling downstream of RAS mutants	29	6.19e-01	-5.34e-02	0.84600
RHO GTPases Activate ROCKs	13	6.21e-01	-7.92e-02	0.84800
Vesicle-mediated transport	426	6.22e-01	1.41e-02	0.84800
Cleavage of the damaged pyrimidine	13	6.24e-01	-7.85e-02	0.84800
Depyrimidination	13	6.24e-01	-7.85e-02	0.84800
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	13	6.24e-01	-7.85e-02	0.84800
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	6.28e-01	8.44e-02	0.85200
Removal of the Flap Intermediate from the C-strand	15	6.29e-01	-7.22e-02	0.85200
Metabolism	1168	6.33e-01	8.58e-03	0.85600
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	6.34e-01	8.70e-02	0.85600
Oxidative Stress Induced Senescence	51	6.34e-01	-3.86e-02	0.85600
Viral Messenger RNA Synthesis	38	6.40e-01	4.39e-02	0.86300
ADP signalling through P2Y purinoceptor 1	13	6.41e-01	-7.47e-02	0.86400
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	37	6.44e-01	4.39e-02	0.86500
Myogenesis	13	6.44e-01	-7.40e-02	0.86500
Peptide ligand-binding receptors	19	6.45e-01	-6.10e-02	0.86500
Regulation of TP53 Expression and Degradation	34	6.46e-01	4.56e-02	0.86500
EPH-Ephrin signaling	54	6.46e-01	-3.62e-02	0.86500
Signaling by BRAF and RAF fusions	42	6.52e-01	-4.02e-02	0.87100
Activation of HOX genes during differentiation	36	6.53e-01	4.34e-02	0.87100
Activation of anterior HOX genes in hindbrain development during early embryogenesis	36	6.53e-01	4.34e-02	0.87100
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	20	6.54e-01	-5.79e-02	0.87200
Interleukin-3, Interleukin-5 and GM-CSF signaling	29	6.57e-01	-4.77e-02	0.87400
RAF activation	27	6.60e-01	-4.90e-02	0.87700
Regulation of pyruvate dehydrogenase (PDH) complex	11	6.62e-01	-7.62e-02	0.87800
ERK/MAPK targets	16	6.62e-01	6.31e-02	0.87800
Protein ubiquitination	55	6.62e-01	-3.41e-02	0.87800
TP53 Regulates Metabolic Genes	60	6.64e-01	3.25e-02	0.87900
Regulation of RUNX1 Expression and Activity	12	6.65e-01	-7.22e-02	0.87900
FCERI mediated MAPK activation	22	6.69e-01	-5.26e-02	0.88300
B-WICH complex positively regulates rRNA expression	25	6.70e-01	4.93e-02	0.88300
Metabolism of lipids	411	6.71e-01	1.24e-02	0.88400
Thrombin signalling through proteinase activated receptors (PARs)	17	6.74e-01	5.90e-02	0.88500
Programmed Cell Death	148	6.74e-01	2.01e-02	0.88500
Purine salvage	11	6.74e-01	-7.32e-02	0.88500
Transcriptional activation of mitochondrial biogenesis	36	6.76e-01	-4.03e-02	0.88500
Downregulation of ERBB2 signaling	15	6.77e-01	6.21e-02	0.88500
Respiratory electron transport	71	6.78e-01	2.86e-02	0.88500
RAF/MAP kinase cascade	148	6.79e-01	-1.98e-02	0.88500
NS1 Mediated Effects on Host Pathways	36	6.80e-01	3.97e-02	0.88500
Metabolism of fat-soluble vitamins	13	6.83e-01	6.55e-02	0.88500
Formation of the Early Elongation Complex	25	6.83e-01	4.72e-02	0.88500
Formation of the HIV-1 Early Elongation Complex	25	6.83e-01	4.72e-02	0.88500
Signaling by FGFR4	24	6.83e-01	4.82e-02	0.88500
Signaling by FGFR in disease	37	6.84e-01	-3.88e-02	0.88500
TNFR1-induced NFkappaB signaling pathway	19	6.86e-01	5.37e-02	0.88500
Negative epigenetic regulation of rRNA expression	40	6.87e-01	3.68e-02	0.88500
Extension of Telomeres	41	6.87e-01	-3.64e-02	0.88500
Negative regulation of MAPK pathway	35	6.89e-01	3.91e-02	0.88500
APC truncation mutants have impaired AXIN binding	12	6.90e-01	6.66e-02	0.88500
AXIN missense mutants destabilize the destruction complex	12	6.90e-01	6.66e-02	0.88500
Signaling by AMER1 mutants	12	6.90e-01	6.66e-02	0.88500
Signaling by APC mutants	12	6.90e-01	6.66e-02	0.88500
Signaling by AXIN mutants	12	6.90e-01	6.66e-02	0.88500
Truncations of AMER1 destabilize the destruction complex	12	6.90e-01	6.66e-02	0.88500
Mitophagy	25	6.92e-01	-4.58e-02	0.88700
HATs acetylate histones	53	6.93e-01	-3.14e-02	0.88700
Cell-cell junction organization	12	6.93e-01	6.58e-02	0.88700
Biological oxidations	74	7.00e-01	2.60e-02	0.89400
Transcriptional Regulation by TP53	273	7.01e-01	1.36e-02	0.89500
Mitochondrial tRNA aminoacylation	16	7.10e-01	-5.37e-02	0.90100
Positive epigenetic regulation of rRNA expression	38	7.11e-01	-3.48e-02	0.90100
RNA Polymerase I Transcription Termination	23	7.11e-01	4.47e-02	0.90100
Processing of Intronless Pre-mRNAs	14	7.13e-01	-5.68e-02	0.90100
Retinoid metabolism and transport	11	7.13e-01	6.41e-02	0.90100
MyD88 cascade initiated on plasma membrane	60	7.13e-01	-2.75e-02	0.90100
Toll Like Receptor 10 (TLR10) Cascade	60	7.13e-01	-2.75e-02	0.90100
Toll Like Receptor 5 (TLR5) Cascade	60	7.13e-01	-2.75e-02	0.90100
Gap-filling DNA repair synthesis and ligation in GG-NER	23	7.13e-01	4.43e-02	0.90100
Regulation of beta-cell development	15	7.14e-01	5.47e-02	0.90100
Signaling by ERBB2	31	7.16e-01	-3.78e-02	0.90100
Response of EIF2AK1 (HRI) to heme deficiency	13	7.16e-01	-5.83e-02	0.90100
Processive synthesis on the lagging strand	13	7.17e-01	5.81e-02	0.90100
Telomere Extension By Telomerase	19	7.18e-01	-4.80e-02	0.90100
Signaling by FGFR2	46	7.18e-01	3.09e-02	0.90100
Base-Excision Repair, AP Site Formation	15	7.21e-01	-5.34e-02	0.90400
Signaling by Leptin	10	7.25e-01	6.42e-02	0.90600
RHO GTPase cycle	271	7.26e-01	-1.25e-02	0.90600
G0 and Early G1	24	7.26e-01	4.13e-02	0.90600
Signaling by EGFR in Cancer	15	7.26e-01	5.22e-02	0.90600
TGF-beta receptor signaling activates SMADs	30	7.28e-01	3.68e-02	0.90600
GABA receptor activation	16	7.28e-01	-5.03e-02	0.90600
Notch-HLH transcription pathway	21	7.30e-01	-4.35e-02	0.90900
Kinesins	30	7.32e-01	-3.61e-02	0.90900
Sensory processing of sound by outer hair cells of the cochlea	15	7.33e-01	-5.09e-02	0.90900
Signaling by FGFR2 in disease	22	7.33e-01	-4.20e-02	0.90900
RHOBTB GTPase Cycle	28	7.37e-01	3.67e-02	0.91200
mRNA 3’-end processing	28	7.37e-01	3.67e-02	0.91200
Lysosome Vesicle Biogenesis	24	7.42e-01	3.89e-02	0.91500
Golgi Associated Vesicle Biogenesis	37	7.42e-01	3.13e-02	0.91500
Metabolism of nucleotides	68	7.42e-01	-2.31e-02	0.91500
Synthesis of bile acids and bile salts	13	7.43e-01	-5.26e-02	0.91500
Transport of Mature mRNA Derived from an Intronless Transcript	37	7.45e-01	3.10e-02	0.91500
G beta:gamma signalling through CDC42	10	7.45e-01	-5.95e-02	0.91500
PI Metabolism	59	7.45e-01	2.45e-02	0.91500
Metabolism of steroids	80	7.47e-01	2.09e-02	0.91500
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	7.48e-01	-3.88e-02	0.91500
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	7.50e-01	5.31e-02	0.91500
Trafficking of AMPA receptors	12	7.50e-01	5.31e-02	0.91500
Diseases associated with the TLR signaling cascade	16	7.51e-01	-4.59e-02	0.91500
Diseases of Immune System	16	7.51e-01	-4.59e-02	0.91500
Synthesis of PIPs at the Golgi membrane	11	7.51e-01	5.53e-02	0.91500
Amyloid fiber formation	27	7.54e-01	3.49e-02	0.91700
Apoptosis	128	7.55e-01	1.60e-02	0.91700
Macroautophagy	87	7.55e-01	1.94e-02	0.91700
Regulation of FZD by ubiquitination	12	7.56e-01	-5.19e-02	0.91700
RAF-independent MAPK1/3 activation	19	7.56e-01	-4.12e-02	0.91700
Nucleotide salvage	18	7.57e-01	-4.22e-02	0.91700
Cell junction organization	22	7.59e-01	3.78e-02	0.91800
NR1H2 and NR1H3-mediated signaling	24	7.60e-01	-3.61e-02	0.91800
Uptake and actions of bacterial toxins	18	7.60e-01	4.16e-02	0.91800
Insulin receptor signalling cascade	25	7.65e-01	-3.45e-02	0.92300
Toll Like Receptor 9 (TLR9) Cascade	64	7.70e-01	2.12e-02	0.92800
Glucose metabolism	69	7.71e-01	2.03e-02	0.92800
Downstream TCR signaling	69	7.72e-01	2.02e-02	0.92800
PCNA-Dependent Long Patch Base Excision Repair	18	7.73e-01	-3.94e-02	0.92800
Signaling by FGFR3	25	7.74e-01	3.31e-02	0.92800
Oncogenic MAPK signaling	54	7.75e-01	-2.25e-02	0.92800
Ovarian tumor domain proteases	28	7.75e-01	3.12e-02	0.92800
Synaptic adhesion-like molecules	10	7.76e-01	-5.21e-02	0.92800
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	16	7.77e-01	-4.10e-02	0.92800
Signaling by FGFR2 IIIa TM	14	7.80e-01	4.32e-02	0.93100
Peptide hormone metabolism	23	7.82e-01	-3.34e-02	0.93100
Diseases of mitotic cell cycle	30	7.82e-01	2.92e-02	0.93100
Regulation of TP53 Activity	130	7.83e-01	1.40e-02	0.93200
NOTCH1 Intracellular Domain Regulates Transcription	37	7.84e-01	-2.61e-02	0.93200
SUMOylation of intracellular receptors	19	7.85e-01	3.62e-02	0.93200
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	21	7.87e-01	3.41e-02	0.93200
Defects in vitamin and cofactor metabolism	16	7.87e-01	3.91e-02	0.93200
RUNX2 regulates osteoblast differentiation	13	7.89e-01	4.30e-02	0.93300
Early Phase of HIV Life Cycle	13	7.89e-01	-4.29e-02	0.93300
RNA Polymerase III Transcription Initiation From Type 3 Promoter	25	7.91e-01	3.06e-02	0.93500
Peroxisomal protein import	45	7.93e-01	2.26e-02	0.93500
G2/M DNA damage checkpoint	51	7.94e-01	-2.11e-02	0.93500
RHOBTB2 GTPase cycle	19	7.95e-01	-3.45e-02	0.93500
RAC1 GTPase cycle	102	7.95e-01	1.49e-02	0.93500
NOTCH3 Intracellular Domain Regulates Transcription	15	7.95e-01	-3.87e-02	0.93500
FOXO-mediated transcription of cell death genes	14	7.97e-01	3.97e-02	0.93600
Diseases of metabolism	119	8.05e-01	1.32e-02	0.94200
RNA Polymerase III Transcription Initiation	32	8.05e-01	2.52e-02	0.94200
Epigenetic regulation of gene expression	70	8.08e-01	1.68e-02	0.94200
RNA Polymerase I Promoter Clearance	42	8.09e-01	-2.16e-02	0.94200
RNA Polymerase I Transcription	42	8.09e-01	-2.16e-02	0.94200
TP53 Regulates Transcription of Cell Cycle Genes	40	8.10e-01	2.20e-02	0.94200
Interleukin receptor SHC signaling	15	8.11e-01	-3.58e-02	0.94200
Regulation of signaling by CBL	14	8.11e-01	3.69e-02	0.94200
IRE1alpha activates chaperones	37	8.11e-01	2.27e-02	0.94200
Negative regulation of MET activity	16	8.11e-01	3.45e-02	0.94200
Recycling pathway of L1	15	8.12e-01	-3.56e-02	0.94200
mTORC1-mediated signalling	17	8.13e-01	-3.31e-02	0.94300
Circadian Clock	50	8.15e-01	-1.91e-02	0.94300
Sphingolipid metabolism	43	8.17e-01	2.04e-02	0.94300
SARS-CoV Infections	109	8.18e-01	1.28e-02	0.94300
Transcriptional Regulation by E2F6	28	8.18e-01	-2.52e-02	0.94300
FGFR2 alternative splicing	21	8.18e-01	2.90e-02	0.94300
Inactivation, recovery and regulation of the phototransduction cascade	16	8.20e-01	-3.28e-02	0.94300
The phototransduction cascade	16	8.20e-01	-3.28e-02	0.94300
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	72	8.21e-01	1.54e-02	0.94300
FGFR2 mutant receptor activation	15	8.22e-01	3.36e-02	0.94300
Pre-NOTCH Expression and Processing	40	8.23e-01	2.05e-02	0.94300
Post-chaperonin tubulin folding pathway	12	8.23e-01	3.74e-02	0.94300
Transcriptional Regulation by MECP2	28	8.25e-01	-2.42e-02	0.94400
TP53 Regulates Transcription of Cell Death Genes	29	8.25e-01	-2.38e-02	0.94400
Signaling by cytosolic FGFR1 fusion mutants	16	8.26e-01	-3.18e-02	0.94400
Aggrephagy	19	8.27e-01	2.90e-02	0.94400
RORA activates gene expression	10	8.29e-01	3.95e-02	0.94600
RNA Polymerase III Abortive And Retractive Initiation	36	8.32e-01	2.05e-02	0.94700
RNA Polymerase III Transcription	36	8.32e-01	2.05e-02	0.94700
Insulin processing	14	8.35e-01	-3.21e-02	0.94900
O-linked glycosylation	39	8.35e-01	1.93e-02	0.94900
Chromosome Maintenance	71	8.36e-01	-1.42e-02	0.94900
Transport of inorganic cations/anions and amino acids/oligopeptides	37	8.37e-01	-1.96e-02	0.94900
Beta-catenin phosphorylation cascade	15	8.37e-01	3.06e-02	0.94900
Platelet sensitization by LDL	13	8.40e-01	3.24e-02	0.95100
CLEC7A (Dectin-1) signaling	81	8.42e-01	-1.28e-02	0.95300
TCR signaling	84	8.43e-01	-1.25e-02	0.95300
Aberrant regulation of mitotic cell cycle due to RB1 defects	29	8.46e-01	2.09e-02	0.95400
RAC2 GTPase cycle	52	8.46e-01	1.56e-02	0.95400
Fc epsilon receptor (FCERI) signaling	103	8.50e-01	-1.08e-02	0.95700
Interleukin-6 signaling	10	8.51e-01	-3.43e-02	0.95800
Regulation of MECP2 expression and activity	20	8.53e-01	-2.40e-02	0.95900
C-type lectin receptors (CLRs)	97	8.54e-01	-1.08e-02	0.95900
NOTCH4 Intracellular Domain Regulates Transcription	14	8.55e-01	-2.82e-02	0.95900
Cellular Senescence	99	8.60e-01	-1.03e-02	0.96100
Caspase activation via extrinsic apoptotic signalling pathway	15	8.61e-01	-2.62e-02	0.96100
HIV elongation arrest and recovery	21	8.63e-01	-2.18e-02	0.96100
Pausing and recovery of HIV elongation	21	8.63e-01	-2.18e-02	0.96100
Pausing and recovery of Tat-mediated HIV elongation	21	8.63e-01	-2.18e-02	0.96100
Tat-mediated HIV elongation arrest and recovery	21	8.63e-01	-2.18e-02	0.96100
Signaling by Rho GTPases	413	8.64e-01	4.99e-03	0.96100
SUMOylation of RNA binding proteins	40	8.64e-01	-1.57e-02	0.96100
EGFR downregulation	20	8.65e-01	-2.20e-02	0.96200
Disease	900	8.68e-01	-3.35e-03	0.96200
SUMOylation of transcription cofactors	35	8.69e-01	-1.61e-02	0.96200
Abortive elongation of HIV-1 transcript in the absence of Tat	17	8.69e-01	2.31e-02	0.96200
Cyclin D associated events in G1	40	8.70e-01	1.50e-02	0.96200
G1 Phase	40	8.70e-01	1.50e-02	0.96200
Estrogen-dependent gene expression	64	8.70e-01	1.18e-02	0.96200
RNA Polymerase III Transcription Initiation From Type 2 Promoter	23	8.71e-01	1.95e-02	0.96300
Leading Strand Synthesis	12	8.74e-01	-2.65e-02	0.96300
Polymerase switching	12	8.74e-01	-2.65e-02	0.96300
Assembly of collagen fibrils and other multimeric structures	10	8.76e-01	-2.86e-02	0.96400
tRNA modification in the nucleus and cytosol	28	8.78e-01	-1.68e-02	0.96600
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	61	8.79e-01	-1.13e-02	0.96700
Golgi-to-ER retrograde transport	91	8.81e-01	9.14e-03	0.96700
Nuclear Receptor transcription pathway	26	8.82e-01	1.69e-02	0.96700
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	8.83e-01	1.91e-02	0.96800
Inwardly rectifying K+ channels	10	8.84e-01	-2.67e-02	0.96800
PINK1-PRKN Mediated Mitophagy	20	8.86e-01	-1.85e-02	0.96900
Interleukin-15 signaling	11	8.87e-01	-2.49e-02	0.96900
Interleukin-10 signaling	13	8.89e-01	-2.24e-02	0.96900
Interleukin-20 family signaling	13	8.89e-01	-2.24e-02	0.96900
PIWI-interacting RNA (piRNA) biogenesis	14	8.89e-01	-2.15e-02	0.96900
Diseases of carbohydrate metabolism	22	8.94e-01	1.64e-02	0.97300
Metabolism of porphyrins	15	8.96e-01	-1.96e-02	0.97300
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	32	8.96e-01	1.34e-02	0.97300
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	28	9.00e-01	1.38e-02	0.97600
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	25	9.00e-01	1.45e-02	0.97600
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	34	9.00e-01	-1.24e-02	0.97600
G-protein activation	10	9.02e-01	2.25e-02	0.97600
Signaling by PDGFR in disease	15	9.02e-01	-1.83e-02	0.97600
Generic Transcription Pathway	771	9.04e-01	-2.62e-03	0.97600
Sensory processing of sound	24	9.06e-01	1.40e-02	0.97700
Sensory processing of sound by inner hair cells of the cochlea	24	9.06e-01	1.40e-02	0.97700
Diseases associated with N-glycosylation of proteins	15	9.07e-01	-1.73e-02	0.97700
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	13	9.08e-01	1.85e-02	0.97700
Potassium Channels	23	9.09e-01	-1.38e-02	0.97700
RHOJ GTPase cycle	34	9.13e-01	-1.09e-02	0.97900
Recruitment of NuMA to mitotic centrosomes	55	9.13e-01	8.57e-03	0.97900
PERK regulates gene expression	25	9.13e-01	-1.26e-02	0.97900
Frs2-mediated activation	11	9.19e-01	-1.78e-02	0.98200
TRAF6 mediated NF-kB activation	17	9.19e-01	1.42e-02	0.98200
Glucagon-type ligand receptors	11	9.19e-01	-1.76e-02	0.98200
Chromatin modifying enzymes	137	9.20e-01	-4.96e-03	0.98200
Chromatin organization	137	9.20e-01	-4.96e-03	0.98200
E3 ubiquitin ligases ubiquitinate target proteins	39	9.21e-01	-9.19e-03	0.98200
DNA Damage/Telomere Stress Induced Senescence	24	9.25e-01	-1.11e-02	0.98400
Signal amplification	17	9.25e-01	-1.32e-02	0.98400
Organelle biogenesis and maintenance	184	9.25e-01	4.03e-03	0.98400
Prolonged ERK activation events	13	9.27e-01	1.47e-02	0.98500
MAP kinase activation	46	9.30e-01	-7.46e-03	0.98700
Ca2+ pathway	34	9.31e-01	-8.64e-03	0.98700
RUNX3 regulates p14-ARF	10	9.32e-01	1.57e-02	0.98700
Inactivation of CSF3 (G-CSF) signaling	20	9.33e-01	-1.09e-02	0.98700
Transport to the Golgi and subsequent modification	124	9.34e-01	4.30e-03	0.98800
Interleukin-12 signaling	35	9.36e-01	-7.87e-03	0.98800
Downregulation of TGF-beta receptor signaling	25	9.38e-01	9.05e-03	0.98800
Signaling by FGFR1	27	9.41e-01	-8.23e-03	0.98800
HSP90 chaperone cycle for steroid hormone receptors (SHR)	32	9.41e-01	7.54e-03	0.98800
G beta:gamma signalling through PI3Kgamma	14	9.42e-01	-1.13e-02	0.98800
Metabolism of cofactors	17	9.42e-01	-1.01e-02	0.98800
PTEN Regulation	105	9.43e-01	4.06e-03	0.98800
Signaling by FGFR	50	9.43e-01	-5.81e-03	0.98800
RHO GTPase Effectors	184	9.44e-01	3.02e-03	0.98800
Adrenaline,noradrenaline inhibits insulin secretion	11	9.44e-01	1.21e-02	0.98800
Bile acid and bile salt metabolism	14	9.44e-01	1.08e-02	0.98800
RNA Polymerase III Transcription Termination	20	9.46e-01	-8.76e-03	0.98800
Post-translational modification: synthesis of GPI-anchored proteins	30	9.46e-01	7.16e-03	0.98800
Interleukin-17 signaling	49	9.46e-01	5.60e-03	0.98800
Interleukin-1 family signaling	92	9.49e-01	-3.90e-03	0.98900
Meiosis	39	9.50e-01	-5.80e-03	0.98900
CDC42 GTPase cycle	91	9.52e-01	3.64e-03	0.98900
Intra-Golgi traffic	38	9.53e-01	-5.51e-03	0.98900
Activation of kainate receptors upon glutamate binding	14	9.59e-01	-8.03e-03	0.98900
RNA Pol II CTD phosphorylation and interaction with CE	23	9.60e-01	6.12e-03	0.98900
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	23	9.60e-01	6.12e-03	0.98900
Signal transduction by L1	11	9.60e-01	-8.65e-03	0.98900
Visual phototransduction	32	9.61e-01	-5.01e-03	0.98900
RNA Polymerase III Chain Elongation	16	9.64e-01	-6.60e-03	0.98900
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	9.65e-01	-5.73e-03	0.98900
Neurodegenerative Diseases	20	9.65e-01	-5.73e-03	0.98900
Signaling by TGF-beta Receptor Complex	59	9.66e-01	-3.23e-03	0.98900
Purine ribonucleoside monophosphate biosynthesis	10	9.67e-01	-7.61e-03	0.98900
trans-Golgi Network Vesicle Budding	50	9.67e-01	-3.38e-03	0.98900
N-Glycan antennae elongation	11	9.67e-01	7.12e-03	0.98900
MyD88 dependent cascade initiated on endosome	62	9.68e-01	2.99e-03	0.98900
Toll Like Receptor 7/8 (TLR7/8) Cascade	62	9.68e-01	2.99e-03	0.98900
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	425	9.68e-01	1.16e-03	0.98900
Translocation of SLC2A4 (GLUT4) to the plasma membrane	43	9.68e-01	-3.56e-03	0.98900
Synthesis of PA	17	9.68e-01	5.56e-03	0.98900
Activation of GABAB receptors	15	9.68e-01	-5.91e-03	0.98900
GABA B receptor activation	15	9.68e-01	-5.91e-03	0.98900
Diseases of glycosylation	67	9.69e-01	-2.79e-03	0.98900
Reproduction	43	9.69e-01	-3.45e-03	0.98900
Signaling by the B Cell Receptor (BCR)	87	9.71e-01	-2.26e-03	0.99000
MAPK targets/ Nuclear events mediated by MAP kinases	22	9.72e-01	4.34e-03	0.99000
RAB GEFs exchange GTP for GDP on RABs	56	9.75e-01	-2.39e-03	0.99200
Thromboxane signalling through TP receptor	12	9.76e-01	5.07e-03	0.99200
CD209 (DC-SIGN) signaling	15	9.77e-01	4.21e-03	0.99300
Centrosome maturation	56	9.80e-01	1.89e-03	0.99400
Recruitment of mitotic centrosome proteins and complexes	56	9.80e-01	1.89e-03	0.99400
Keratan sulfate biosynthesis	14	9.81e-01	3.71e-03	0.99400
G alpha (12/13) signalling events	33	9.82e-01	-2.26e-03	0.99400
FGFR1 mutant receptor activation	19	9.85e-01	-2.54e-03	0.99400
Interleukin-35 Signalling	11	9.86e-01	3.04e-03	0.99400
Synthesis of PIPs at the plasma membrane	36	9.87e-01	1.55e-03	0.99400
Signaling by Hippo	11	9.87e-01	-2.77e-03	0.99400
Lagging Strand Synthesis	17	9.89e-01	-2.02e-03	0.99400
Keratan sulfate/keratin metabolism	18	9.89e-01	-1.92e-03	0.99400
XBP1(S) activates chaperone genes	36	9.89e-01	1.32e-03	0.99400
RNA Polymerase III Transcription Initiation From Type 1 Promoter	24	9.89e-01	-1.62e-03	0.99400
Neurotransmitter release cycle	18	9.89e-01	1.83e-03	0.99400
Interleukin-12 family signaling	41	9.93e-01	8.49e-04	0.99600
HCMV Infection	67	9.96e-01	-3.35e-04	0.99900
Base Excision Repair	38	9.98e-01	2.62e-04	1.00000
RND1 GTPase cycle	29	9.99e-01	-1.40e-04	1.00000
mRNA decay by 3’ to 5’ exoribonuclease	13	1.00e+00	-9.37e-05	1.00000

Detailed Gene set reports

Metabolism of RNA

Metabolism of RNA
	504
set	Metabolism of RNA
setSize	498
pANOVA	1.38e-06
s.dist	0.128
p.adjustANOVA	0.00158

Top enriched genes

Top 20 genes
GeneID	Gene Rank
NCBP1	8402
SNRPC	8378
PES1	8341
RNU12	8329
SNRPN	8320
GLE1	8318
RPS25	8288
DDX47	8287
CWC22	8283
TSEN54	8251
RPS27A	8228
RCL1	8222
SNRPD3	8221
CNOT7	8204
CDK7	8195
PSMA3	8188
RPS3	8185
RPS6	8168
RPS28	8167
RNU11	8142

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
NCBP1	8402
SNRPC	8378
PES1	8341
RNU12	8329
SNRPN	8320
GLE1	8318
RPS25	8288
DDX47	8287
CWC22	8283
TSEN54	8251
RPS27A	8228
RCL1	8222
SNRPD3	8221
CNOT7	8204
CDK7	8195
PSMA3	8188
RPS3	8185
RPS6	8168
RPS28	8167
RNU11	8142
PUS3	8141
NUP35	8140
RPL4	8137
PRPF3	8106
RPSA	8071
NUP107	8020
EIF4A2	8016
RPS24	7985
CSNK1E	7983
SNRPD2	7972
GEMIN7	7971
RPL34	7954
GEMIN6	7934
DNAJC8	7931
RPL3	7916
CDKAL1	7908
NSUN6	7900
WBSCR22	7872
SF3A2	7866
SNRNP40	7841
EDC4	7800
PAN2	7799
FBL	7793
HNRNPC	7786
RPL15	7772
NUP98	7764
RIOK2	7755
MNAT1	7743
UTP20	7701
LSM10	7694
GAR1	7687
TFIP11	7655
PARN	7647
PPIL6	7640
RPL28	7634
RPP30	7603
PSMB5	7598
CHERP	7588
PRPF31	7586
C1D	7585
BYSL	7563
WDR75	7541
RPS20	7538
POLR2K	7535
ELAC2	7506
RPL38	7481
DDX42	7469
WDR18	7463
RPL9	7462
ZBTB8OS	7434
UBB	7418
UTP6	7403
DDX52	7367
HBS1L	7361
RAN	7323
ERCC2	7313
SMG5	7295
RPL41	7287
SRRM1	7240
CDC40	7236
PSMC1	7227
RPL26	7225
SNW1	7224
THUMPD1	7215
POLDIP3	7198
RPL26L1	7153
EXOSC10	7129
HNRNPH1	7063
PAIP1	7052
PSMA5	7049
TRMU	7048
PRCC	7046
NUP62	7023
DCP1B	7016
PSMD12	7015
RPP14	7012
SET	7004
SMG1	6991
PPIL3	6931
PCBP1	6928
TPR	6893
RPL32	6861
SYF2	6860
PSME2	6844
PSMB10	6829
U2AF1L4	6821
LSM6	6797
NCBP2	6756
PHAX	6753
NUP133	6710
POLR2G	6708
NXF1	6707
PABPN1	6672
PSMB7	6667
PAN3	6662
SLBP	6615
DCAF13	6595
RPL37A	6591
PSMB6	6558
TRIT1	6557
RPS23	6550
PSMD11	6544
RPL23	6505
LSM7	6494
FCF1	6479
TP53RK	6464
EDC3	6434
ZCCHC6	6428
SF3B4	6419
RPL37	6405
LTV1	6380
RPS16	6351
WBP11	6347
SNRPA	6333
C2orf49	6328
SNRPA1	6325
WDR77	6314
DDX23	6302
SNRPE	6300
TPRKB	6271
NUP205	6267
THOC5	6249
MPHOSPH6	6246
PDCD7	6212
SF3B5	6211
LSM2	6198
SMNDC1	6156
SART1	6130
PRMT5	6109
EXOSC6	6042
GTPBP3	6011
PSMC6	5996
RRP7A	5962
GTF2F2	5927
EIF4A1	5915
RPS10	5908
IGF2BP1	5883
POP4	5860
YWHAZ	5837
IMP4	5827
TBL3	5814
UBC	5810
CNOT8	5785
EIF4A3	5779
NUP160	5658
RPS18	5632
RPL27A	5614
PABPC1	5582
HNRNPUL1	5579
ZFP36L1	5570
CNOT6L	5569
RPS8	5562
NOP10	5553
PSMB3	5497
QTRT1	5490
PPP2R2A	5472
XPOT	5466
UBA52	5448
WDR12	5442
ALKBH8	5418
PPIL1	5396
PRPF19	5393
HNRNPK	5391
ISY1	5327
PSMD4	5325
TNKS1BP1	5298
POLR2B	5291
RPL29	5290
CTNNBL1	5289
DCPS	5228
THADA	5184
RPS29	5166
SNRNP70	5116
CWC15	5096
PSMD7	5075
POM121C	5072
PNO1	5053
WDR43	5052
RPL22	5041
HNRNPU	5008
UTP15	4993
PSMB1	4974
ZFP36	4950
PRPF6	4948
POP7	4929
ADAT1	4927
THOC1	4926
TRDMT1	4922
RANBP2	4903
CRNKL1	4891
SNRNP27	4890
SNRPB	4874
DCP1A	4837
NOL6	4802
DDX20	4703
SENP3	4693
PSMF1	4670
EXOSC7	4662
PSMD1	4661
RPS9	4648
RPL6	4621
RPL36	4617
RNGTT	4613
PSMD9	4605
SF3B2	4587
LSM3	4544
SYMPK	4534
USP39	4527
RPS3A	4514
CLP1	4503
TTC37	4449
RPL17	4433
SNRPG	4428
NOB1	4405
IMP3	4395
RPL11	4330
XPO1	4303
PELP1	4290
PPIH	4252
SF3B3	4250
PDCD11	4218
UTP3	4201
SUPT5H	4179
RPS27L	4151
FTSJ3	4146
PUS7	4126
PTBP1	4122
PPIE	4108
XAB2	4099
NOL12	4088
POM121	4069
CDC5L	4035
ERCC3	4023
CPSF2	4004
PSME3	3994
THG1L	3987
CSTF1	3962
HNRNPD	3947
HEATR1	3939
LSM4	3901
BMS1	3878
EBNA1BP2	3873
SKIV2L	3863
LSM5	3840
POLR2C	3775
FAM98B	3772
NUP54	3754
NSUN4	3736
PCBP2	3727
NUP188	3714
TRNT1	3712
PSMD14	3709
RNMT	3703
SNRPB2	3677
NUP85	3668
NUDT21	3640
PSMD2	3621
SNRNP48	3610
HNRNPM	3606
MRM1	3590
CLNS1A	3571
POP5	3562
RPL31	3555
TRMT61B	3550
UPF1	3538
EXOSC2	3525
PRKCA	3486
SNRNP200	3481
DDX21	3469
EXOSC8	3443
RPLP1	3408
WTAP	3380
METTL1	3365
RPS12	3328
SF1	3310
HSPA1A	3274
PSMA6	3273
LSM11	3268
SRRM2	3259
PSMC3	3247
NOL11	3213
PSMB9	3199
NUP93	3175
ENPP2	3135
CNOT1	3125
NUP155	3101
RPLP0	3049
DDX6	3031
RBM28	3026
PSMD8	3011
NXT1	2961
CCAR1	2954
U2AF2	2952
TSEN15	2949
DIS3	2928
PSMA7	2927
CTU1	2912
XRN2	2897
PPP2CA	2847
DHX9	2843
TFB1M	2841
HNRNPL	2831
RPS26	2822
IGF2BP3	2812
PPIL4	2797
SLU7	2793
U2AF1	2776
RNPC3	2772
POLR2E	2768
CASC3	2750
GEMIN5	2733
GTF2H4	2685
EIF4B	2671
RPS19	2666
PSMD13	2662
NOP14	2648
TRMT11	2642
WDR61	2635
NUP43	2582
MAPKAPK2	2575
PRPF38A	2573
PSMD3	2545
UPF2	2503
PSMC5	2470
TNPO1	2469
AQR	2428
SNRNP25	2423
PSMD6	2403
RIOK1	2384
LSM1	2373
RPS7	2356
HNRNPA2B1	2348
DHX16	2330
CD2BP2	2299
RAE1	2287
NUP214	2228
RPL14	2209
RPS11	2201
RNPS1	2173
UPF3A	2172
YBX1	2163
RPL18	2150
RPL7	2139
PSMC4	2130
WDR36	2073
SF3A3	2044
GSPT1	2009
NUP210	2001
ADAT2	1991
CNOT3	1955
NUP50	1921
ADAT3	1906
RPL35	1903
EIF4G1	1882
ZCCHC11	1872
PSMA1	1855
PRPF8	1852
GTF2F1	1836
AAAS	1828
RPP21	1823
CNOT4	1813
PLRG1	1766
DDX1	1753
NOP56	1724
LCMT2	1719
NUP153	1709
TRMT1	1695
MAPK14	1668
PAPOLA	1653
DCP2	1533
SMG7	1498
WDR33	1490
TRMT61A	1453
RPLP2	1447
WDR3	1443
NUP37	1438
PSMA2	1432
TSR1	1421
URM1	1362
SNRPD1	1350
NOP58	1322
EXOSC4	1277
RRP1	1248
RPS5	1210
RIOK3	1192
HNRNPF	1175
SNUPN	1170
ADAR	1168
TEX10	1160
BUD31	1158
RPS15	1135
POLR2A	1117
CSNK1D	1107
RPL23A	1098
MPHOSPH10	1092
CD44	1077
HNRNPA0	1046
RRP9	1022
GTF2H3	1021
POLR2H	1005
CNOT10	1000
ISG20L2	997
RPP25	991
NOP2	904
CCNH	888
NCL	872
SEH1L	844
RPP38	823
NIP7	820
DDX5	765
PSMB8	756
ADARB1	722
POLR2I	691
DHX37	689
NOC4L	665
ANP32A	658
FUS	646
CNOT6	634
NSUN2	618
PWP2	608
PATL1	604
FIP1L1	598
MTO1	594
KHSRP	558
TRMT12	551
YWHAB	506
EXOSC3	501
DDX46	489
RPL39L	485
EFTUD2	371
TNFSF13	367
RPL13	339
POLR2F	337
FYTTD1	314
NHP2	301
TYW1	284
TYW3	244
FAU	233
GNL3	216
PSME1	209
PSME4	207
HSPB1	159
PPWD1	143
PNRC2	96
RPS15A	72
CPSF4	65
METTL14	62
SNRNP35	-6
ETF1	-25
GTF2H5	-35
PUF60	-56
TXNL4A	-98
SF3A1	-202
HNRNPR	-218
POLR2D	-240
POP1	-251
CPSF1	-275
RPL8	-295
ACTB	-298
RBM17	-372
DDX49	-412
RPP40	-457
EXOSC5	-485
SEC13	-516
RPL10A	-562
EIF4E	-590
TSEN2	-657
WBP4	-845
ERI1	-851
PRKCD	-938
CPSF3	-995
SRRT	-999
AKT1	-1052
RPL36AL	-1188
PUS1	-1191
THOC7	-1303
CTU2	-1305
ZMAT5	-1367

Mitotic Metaphase and Anaphase

Mitotic Metaphase and Anaphase
	542
set	Mitotic Metaphase and Anaphase
setSize	186
pANOVA	8.41e-05
s.dist	0.168
p.adjustANOVA	0.038

Top enriched genes

Top 20 genes
GeneID	Gene Rank
ZWILCH	8324
CDC23	8244
RPS27A	8228
PSMA3	8188
NUP35	8140
SKA2	8095
SPC25	8021
NUP107	8020
VRK2	8002
TUBA1A	7982
ITGB3BP	7906
KIF2A	7884
PPP2R1B	7877
CCNB2	7856
NUP98	7764
CHMP6	7662
PSMB5	7598
TUBA4A	7569
BANF1	7554
UBB	7418

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
ZWILCH	8324
CDC23	8244
RPS27A	8228
PSMA3	8188
NUP35	8140
SKA2	8095
SPC25	8021
NUP107	8020
VRK2	8002
TUBA1A	7982
ITGB3BP	7906
KIF2A	7884
PPP2R1B	7877
CCNB2	7856
NUP98	7764
CHMP6	7662
PSMB5	7598
TUBA4A	7569
BANF1	7554
UBB	7418
PTTG1	7353
RAD21	7352
RANGAP1	7332
CENPK	7331
RAN	7323
ANAPC7	7272
PSMC1	7227
CDCA8	7190
KNTC1	7127
PSMA5	7049
NUP62	7023
PSMD12	7015
CENPH	7000
NUF2	6976
BUB1B	6952
PPP2R5E	6882
MAD2L1	6862
PSME2	6844
PSMB10	6829
LEMD2	6806
MAPRE1	6750
NUP133	6710
CHMP4B	6687
FBXO5	6669
PSMB7	6667
CDC20	6613
BUB3	6580
PSMB6	6558
PSMD11	6544
SMC3	6498
CHMP2A	6470
ANAPC10	6447
VRK1	6441
CLASP2	6396
PPP2R5D	6390
UBE2C	6275
NUP205	6267
NSL1	6255
CENPO	6228
SUMO1	6159
ANAPC5	6000
PSMC6	5996
KIF2C	5934
ZWINT	5868
UBC	5810
CENPE	5698
NUP160	5658
AHCTF1	5566
PSMB3	5497
PPP2R2A	5472
NDE1	5467
ESPL1	5459
UBA52	5448
PSMD4	5325
TUBA1C	5273
CLASP1	5253
BIRC5	5224
ANAPC1	5142
STAG1	5087
PSMD7	5075
PSMB1	4974
DYNLL2	4965
RANBP2	4903
AURKB	4882
CENPM	4808
RCC1	4803
LMNA	4679
ZW10	4675
PSMF1	4670
PSMD1	4661
CENPF	4636
VPS4A	4622
CENPQ	4612
PSMD9	4605
ANAPC4	4531
CHMP2B	4483
PPP2R5B	4371
XPO1	4303
ANAPC11	4297
SPC24	4230
TMPO	4115
POM121	4069
INCENP	4041
LMNB1	4000
PSME3	3994
NDC80	3903
SIRT2	3829
TUBB2A	3793
CENPL	3755
NUP54	3754
LEMD3	3740
NUP188	3714
PSMD14	3709
NUP85	3668
PSMD2	3621
PMF1	3508
CDCA5	3307
PSMA6	3273
PSMC3	3247
PSMB9	3199
TUBA1B	3184
NUP93	3175
BUB1	3149
PPP1CC	3143
NUP155	3101
PPP2R5A	3085
UBE2E1	3040
PSMD8	3011
PSMA7	2927
CC2D1B	2926
PLK1	2868
PPP2CA	2847
CDC16	2815
CHMP4A	2746
PSMD13	2662
CENPN	2589
NUP43	2582
DSN1	2568
CDK1	2546
PSMD3	2545
PSMC5	2470
TNPO1	2469
PSMD6	2403
DYNC1I2	2184
PSMC4	2130
B9D2	2128
PPP2R5C	2104
UBE2D1	1866
PSMA1	1855
TAOK1	1847
CHMP7	1840
LBR	1829
DYNC1LI1	1660
SPAST	1651
NUDC	1526
NUP37	1438
PSMA2	1432
CKAP5	1363
KIF18A	1274
MAD1L1	1233
RCC2	1194
DYNC1LI2	881
SEH1L	844
PSMB8	756
PAFAH1B1	687
DYNLL1	677
DYNC1H1	425
KPNB1	363
CENPT	313
PSME1	209
PSME4	207
PDS5A	166
MIS12	137
UBE2I	-28
NDEL1	-63
CENPA	-64
ANAPC2	-135
CLIP1	-399
CENPP	-475
SEC13	-516
TUBA4B	-578
PDS5B	-583
PPP2CB	-624
ANKLE2	-905
CCNB1	-1067
APITD1	-1142

Mitotic Anaphase

Mitotic Anaphase
	539
set	Mitotic Anaphase
setSize	185
pANOVA	0.000113
s.dist	0.165
p.adjustANOVA	0.038

Top enriched genes

Top 20 genes
GeneID	Gene Rank
ZWILCH	8324
CDC23	8244
RPS27A	8228
PSMA3	8188
NUP35	8140
SKA2	8095
SPC25	8021
NUP107	8020
VRK2	8002
TUBA1A	7982
ITGB3BP	7906
KIF2A	7884
PPP2R1B	7877
CCNB2	7856
NUP98	7764
CHMP6	7662
PSMB5	7598
TUBA4A	7569
BANF1	7554
UBB	7418

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
ZWILCH	8324
CDC23	8244
RPS27A	8228
PSMA3	8188
NUP35	8140
SKA2	8095
SPC25	8021
NUP107	8020
VRK2	8002
TUBA1A	7982
ITGB3BP	7906
KIF2A	7884
PPP2R1B	7877
CCNB2	7856
NUP98	7764
CHMP6	7662
PSMB5	7598
TUBA4A	7569
BANF1	7554
UBB	7418
PTTG1	7353
RAD21	7352
RANGAP1	7332
CENPK	7331
RAN	7323
ANAPC7	7272
PSMC1	7227
CDCA8	7190
KNTC1	7127
PSMA5	7049
NUP62	7023
PSMD12	7015
CENPH	7000
NUF2	6976
BUB1B	6952
PPP2R5E	6882
MAD2L1	6862
PSME2	6844
PSMB10	6829
LEMD2	6806
MAPRE1	6750
NUP133	6710
CHMP4B	6687
PSMB7	6667
CDC20	6613
BUB3	6580
PSMB6	6558
PSMD11	6544
SMC3	6498
CHMP2A	6470
ANAPC10	6447
VRK1	6441
CLASP2	6396
PPP2R5D	6390
UBE2C	6275
NUP205	6267
NSL1	6255
CENPO	6228
SUMO1	6159
ANAPC5	6000
PSMC6	5996
KIF2C	5934
ZWINT	5868
UBC	5810
CENPE	5698
NUP160	5658
AHCTF1	5566
PSMB3	5497
PPP2R2A	5472
NDE1	5467
ESPL1	5459
UBA52	5448
PSMD4	5325
TUBA1C	5273
CLASP1	5253
BIRC5	5224
ANAPC1	5142
STAG1	5087
PSMD7	5075
PSMB1	4974
DYNLL2	4965
RANBP2	4903
AURKB	4882
CENPM	4808
RCC1	4803
LMNA	4679
ZW10	4675
PSMF1	4670
PSMD1	4661
CENPF	4636
VPS4A	4622
CENPQ	4612
PSMD9	4605
ANAPC4	4531
CHMP2B	4483
PPP2R5B	4371
XPO1	4303
ANAPC11	4297
SPC24	4230
TMPO	4115
POM121	4069
INCENP	4041
LMNB1	4000
PSME3	3994
NDC80	3903
SIRT2	3829
TUBB2A	3793
CENPL	3755
NUP54	3754
LEMD3	3740
NUP188	3714
PSMD14	3709
NUP85	3668
PSMD2	3621
PMF1	3508
CDCA5	3307
PSMA6	3273
PSMC3	3247
PSMB9	3199
TUBA1B	3184
NUP93	3175
BUB1	3149
PPP1CC	3143
NUP155	3101
PPP2R5A	3085
UBE2E1	3040
PSMD8	3011
PSMA7	2927
CC2D1B	2926
PLK1	2868
PPP2CA	2847
CDC16	2815
CHMP4A	2746
PSMD13	2662
CENPN	2589
NUP43	2582
DSN1	2568
CDK1	2546
PSMD3	2545
PSMC5	2470
TNPO1	2469
PSMD6	2403
DYNC1I2	2184
PSMC4	2130
B9D2	2128
PPP2R5C	2104
UBE2D1	1866
PSMA1	1855
TAOK1	1847
CHMP7	1840
LBR	1829
DYNC1LI1	1660
SPAST	1651
NUDC	1526
NUP37	1438
PSMA2	1432
CKAP5	1363
KIF18A	1274
MAD1L1	1233
RCC2	1194
DYNC1LI2	881
SEH1L	844
PSMB8	756
PAFAH1B1	687
DYNLL1	677
DYNC1H1	425
KPNB1	363
CENPT	313
PSME1	209
PSME4	207
PDS5A	166
MIS12	137
UBE2I	-28
NDEL1	-63
CENPA	-64
ANAPC2	-135
CLIP1	-399
CENPP	-475
SEC13	-516
TUBA4B	-578
PDS5B	-583
PPP2CB	-624
ANKLE2	-905
CCNB1	-1067
APITD1	-1142

Translation

Translation
	1066
set	Translation
setSize	225
pANOVA	0.000133
s.dist	0.149
p.adjustANOVA	0.038

Top enriched genes

Top 20 genes
GeneID	Gene Rank
EIF4H	8386
TARS2	8362
RPS25	8288
RPS27A	8228
MRPL47	8226
AURKAIP1	8219
SSR2	8207
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
OXA1L	8131
MRPS21	8122
PTCD3	8109
RPSA	8071
MRPL30	8047
MRPL19	8025
EIF4A2	8016
MRPS33	7992
RPS24	7985

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
EIF4H	8386
TARS2	8362
RPS25	8288
RPS27A	8228
MRPL47	8226
AURKAIP1	8219
SSR2	8207
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
OXA1L	8131
MRPS21	8122
PTCD3	8109
RPSA	8071
MRPL30	8047
MRPL19	8025
EIF4A2	8016
MRPS33	7992
RPS24	7985
MRPS31	7966
EIF3K	7962
RPL34	7954
RPL3	7916
ERAL1	7911
MRPS10	7836
GADD45GIP1	7827
MRPL42	7815
RPL15	7772
MRPL27	7736
SRP14	7728
MRPL10	7697
MRPS11	7667
RPL28	7634
DAP3	7632
RPS20	7538
TUFM	7516
MRPL39	7494
RPL38	7481
RPL9	7462
MRPS27	7438
MRPL37	7358
MRPL55	7303
EARS2	7289
RPL41	7287
CHCHD1	7269
RPL26	7225
RPL26L1	7153
MRPL13	7092
MRPS16	7028
MRPL1	7006
EIF2S1	6910
MRPL35	6889
APEH	6876
RPL32	6861
MTIF2	6816
EEF1B2	6724
MRPL2	6617
RPL37A	6591
RPS23	6550
RPL23	6505
EIF3A	6467
MRPL46	6439
TSFM	6415
RPL37	6405
MRPS30	6402
MRPL54	6395
MRPS36	6353
RPS16	6351
EIF3E	6310
EIF3B	6240
MRPL20	6209
MRPS26	6194
SEC11A	5992
EIF5B	5991
EEF2	5988
EIF4EBP1	5966
EIF4A1	5915
RPS10	5908
MRPS23	5857
SPCS3	5750
SRP19	5734
RPS18	5632
SRP72	5621
RPL27A	5614
MRPL12	5591
PABPC1	5582
RPS8	5562
RPN2	5499
UBA52	5448
FARSB	5363
SRP54	5353
RPL29	5290
MRPS12	5286
MRPL22	5218
SEC61A2	5197
MRPL24	5181
MRPL52	5168
RPS29	5166
MRPS17	5154
EIF3H	5136
YARS2	5089
MRPL48	5073
RPL22	5041
EIF3F	4913
EEF1E1	4897
PPA2	4858
SPCS2	4754
SEC61G	4736
MRPL45	4727
MRPL44	4705
RPS9	4648
MRPS18B	4629
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
MRPS28	4382
RPL11	4330
EIF2S2	4264
MTRF1L	4244
MARS2	4188
NARS2	4161
RPS27L	4151
MRPL32	4062
MRPL49	4037
MRPS18A	3867
MRPL34	3831
MRPS18C	3802
EEF1A1	3605
RPL31	3555
MRPS9	3510
VARS2	3461
RPLP1	3408
WARS2	3396
RPS12	3328
FARSA	3204
N6AMT1	3174
GFM2	3148
HARS2	3147
PARS2	3144
RPLP0	3049
SRPRB	3037
RPS26	2822
EIF5	2798
MRPS2	2764
EIF4B	2671
RPS19	2666
MRPS5	2651
MRPL33	2630
MRPL18	2600
MRPS15	2580
SSR3	2528
MRPL15	2411
RPS7	2356
RPL14	2209
RPN1	2203
RPS11	2201
SEC11C	2181
RPL18	2150
RPL7	2139
MRPS22	2055
GSPT1	2009
EIF2B3	1983
LARS2	1908
RPL35	1903
EIF4G1	1882
MTIF3	1863
MRPS34	1675
GFM1	1669
MRPL51	1507
RPLP2	1447
MRPL23	1446
MRPS14	1431
AARS2	1413
SRP68	1381
RARS2	1340
EIF3J	1279
RPS5	1210
RPS15	1135
RPL23A	1098
MRPS25	1033
MRPL14	990
EEF1D	959
MRPS35	902
EIF3L	880
MRPL4	787
CARS2	782
MRPS6	774
EIF2B5	770
EIF2B2	753
PPA1	745
MTFMT	729
MRPL53	726
SEC61A1	663
RPL39L	485
MRPS7	442
EIF2B1	353
RPL13	339
FAU	233
EEF1G	186
EIF2B4	180
MRPL11	147
RPS15A	72
ETF1	-25
MRPL41	-27
MRPS24	-87
MRPL21	-102
EIF3M	-129
MRPL38	-142
EIF3G	-171
EIF3I	-201
IARS2	-241
RPL8	-295
SSR1	-313
MRPL36	-314
RPL10A	-562
EIF4E	-590
SARS2	-606
MRPL50	-611
TRAM1	-687
MRPL43	-1040
RPL36AL	-1188
AIMP2	-1212
MRPL16	-1346

NOTCH3 Activation and Transmission of Signal to the Nucleus

NOTCH3 Activation and Transmission of Signal to the Nucleus
	564
set	NOTCH3 Activation and Transmission of Signal to the Nucleus
setSize	15
pANOVA	0.000242
s.dist	0.547
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
NCSTN	8369
TACC3	8325
RPS27A	8228
WWP2	7914
UBB	7418
APH1A	6905
PSEN1	6541
APH1B	6499
PSENEN	6061
UBC	5810
MIB1	5480
UBA52	5448
ADAM10	5018
PSEN2	2706
YBX1	2163

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
NCSTN	8369
TACC3	8325
RPS27A	8228
WWP2	7914
UBB	7418
APH1A	6905
PSEN1	6541
APH1B	6499
PSENEN	6061
UBC	5810
MIB1	5480
UBA52	5448
ADAM10	5018
PSEN2	2706
YBX1	2163

PLC beta mediated events

PLC beta mediated events
	641
set	PLC beta mediated events
setSize	29
pANOVA	0.000292
s.dist	-0.389
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
GNA15	-1343
PLCB3	-1010
PRKCD	-938
PLCB2	-912
CAMK2D	-628
ADCY7	-609
CAMKK1	-336
PDE1B	-308
CREB1	-273
PRKAR1A	-147
ITPR2	190
AHCYL1	266
CAMKK2	293
ADCY4	377
PRKACA	480
PRKAR2A	771
NBEA	1043
PRKACB	1167
ITPR3	1758
CAMK4	1835

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
GNA15	-1343
PLCB3	-1010
PRKCD	-938
PLCB2	-912
CAMK2D	-628
ADCY7	-609
CAMKK1	-336
PDE1B	-308
CREB1	-273
PRKAR1A	-147
ITPR2	190
AHCYL1	266
CAMKK2	293
ADCY4	377
PRKACA	480
PRKAR2A	771
NBEA	1043
PRKACB	1167
ITPR3	1758
CAMK4	1835
CALM1	2569
ADCY9	2727
MAPK1	3217
PRKCA	3486
KPNA2	3922
CAMK2G	6968
PRKAR1B	7076
ITPR1	7110
GNAQ	7124

DAG and IP3 signaling

DAG and IP3 signaling
	174
set	DAG and IP3 signaling
setSize	26
pANOVA	0.000363
s.dist	-0.404
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
PRKCD	-938
CAMK2D	-628
ADCY7	-609
PRKCE	-493
CAMKK1	-336
PDE1B	-308
CREB1	-273
PRKAR1A	-147
ITPR2	190
AHCYL1	266
CAMKK2	293
ADCY4	377
PRKACA	480
PRKAR2A	771
PLCG1	848
NBEA	1043
PRKACB	1167
ITPR3	1758
CAMK4	1835
CALM1	2569

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
PRKCD	-938
CAMK2D	-628
ADCY7	-609
PRKCE	-493
CAMKK1	-336
PDE1B	-308
CREB1	-273
PRKAR1A	-147
ITPR2	190
AHCYL1	266
CAMKK2	293
ADCY4	377
PRKACA	480
PRKAR2A	771
PLCG1	848
NBEA	1043
PRKACB	1167
ITPR3	1758
CAMK4	1835
CALM1	2569
ADCY9	2727
PRKCA	3486
KPNA2	3922
CAMK2G	6968
PRKAR1B	7076
ITPR1	7110

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
	819
set	Regulation of expression of SLITs and ROBOs
setSize	117
pANOVA	0.000473
s.dist	0.188
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
NCBP1	8402
RPS25	8288
RPS27A	8228
PSMA3	8188
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
PSMB5	7598
RPS20	7538
RPL38	7481
RPL9	7462
UBB	7418
RPL41	7287

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
NCBP1	8402
RPS25	8288
RPS27A	8228
PSMA3	8188
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
PSMB5	7598
RPS20	7538
RPL38	7481
RPL9	7462
UBB	7418
RPL41	7287
PSMC1	7227
RPL26	7225
RPL26L1	7153
PSMA5	7049
PSMD12	7015
RPL32	6861
PSME2	6844
PSMB10	6829
NCBP2	6756
PSMB7	6667
RPL37A	6591
PSMB6	6558
RPS23	6550
PSMD11	6544
USP33	6511
RPL23	6505
RPL37	6405
RPS16	6351
PSMC6	5996
RPS10	5908
UBC	5810
EIF4A3	5779
RPS18	5632
RPL27A	5614
PABPC1	5582
RPS8	5562
PSMB3	5497
LDB1	5453
UBA52	5448
PSMD4	5325
RPL29	5290
RPS29	5166
PSMD7	5075
RPL22	5041
PSMB1	4974
PSMF1	4670
PSMD1	4661
RPS9	4648
RPL6	4621
RPL36	4617
PSMD9	4605
RPS3A	4514
RPL17	4433
RPL11	4330
RPS27L	4151
CUL2	4094
PSME3	3994
PSMD14	3709
PSMD2	3621
RPL31	3555
RPLP1	3408
RPS12	3328
PSMA6	3273
PSMC3	3247
PSMB9	3199
RPLP0	3049
PSMD8	3011
PSMA7	2927
RPS26	2822
CASC3	2750
RPS19	2666
PSMD13	2662
PSMD3	2545
UPF2	2503
PSMC5	2470
PSMD6	2403
RPS7	2356
RPL14	2209
RPS11	2201
RNPS1	2173
UPF3A	2172
RPL18	2150
RPL7	2139
PSMC4	2130
GSPT1	2009
RPL35	1903
EIF4G1	1882
PSMA1	1855
RPLP2	1447
PSMA2	1432
RPS5	1210
RPS15	1135
DAG1	1109
RPL23A	1098
PSMB8	756
RBX1	651
RPL39L	485
RPL13	339
FAU	233
PSME1	209
PSME4	207
RPS15A	72
ETF1	-25
RPL8	-295
RPL10A	-562
SLIT1	-672
RPL36AL	-1188

Selenocysteine synthesis

Selenocysteine synthesis
	882
set	Selenocysteine synthesis
setSize	65
pANOVA	0.000477
s.dist	0.251
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
EEFSEC	7576
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
RPL32	6861

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
EEFSEC	7576
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
RPL32	6861
RPL37A	6591
RPS23	6550
RPL23	6505
RPL37	6405
RPS16	6351
RPS10	5908
RPS18	5632
RPL27A	5614
RPS8	5562
UBA52	5448
RPL29	5290
RPS29	5166
RPL22	5041
SEPHS2	4943
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
RPL11	4330
RPS27L	4151
PSTK	3968
RPL31	3555
RPLP1	3408
RPS12	3328
RPLP0	3049
RPS26	2822
RPS19	2666
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
RPL35	1903
RPLP2	1447
RPS5	1210
RPS15	1135
RPL23A	1098
RPL39L	485
RPL13	339
FAU	233
RPS15A	72
RPL8	-295
RPL10A	-562
RPL36AL	-1188

Signaling by GPCR

Signaling by GPCR
	922
set	Signaling by GPCR
setSize	195
pANOVA	0.000588
s.dist	-0.144
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
RGS3	-1407
FZD8	-1349
GNA15	-1343
NLN	-1321
ADORA3	-1302
ADORA2A	-1279
RGS1	-1268
GNG12	-1213
HRH2	-1173
CDC42	-1172
PRKCB	-1153
AKT1	-1052
PLCB3	-1010
GNB1	-1002
PRKCD	-938
DHH	-921
LHB	-919
APP	-913
PLCB2	-912
CD55	-891

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
RGS3	-1407
FZD8	-1349
GNA15	-1343
NLN	-1321
ADORA3	-1302
ADORA2A	-1279
RGS1	-1268
GNG12	-1213
HRH2	-1173
CDC42	-1172
PRKCB	-1153
AKT1	-1052
PLCB3	-1010
GNB1	-1002
PRKCD	-938
DHH	-921
LHB	-919
APP	-913
PLCB2	-912
CD55	-891
RGS19	-788
KRAS	-784
OPRL1	-767
QRFP	-760
DGKH	-747
CAMK2D	-628
RPS6KA1	-627
PPP2CB	-624
DGKA	-610
ADCY7	-609
PREX1	-593
PPP3CA	-532
TRIO	-525
GIPR	-497
PRKCE	-493
PPP3CC	-471
LPAR5	-429
HCRT	-375
GPR176	-360
CAMKK1	-336
PDE1B	-308
CREB1	-273
GNAT1	-243
PDE2A	-173
PRKAR1A	-147
PPP3R1	-141
DRD3	-92
ARHGEF12	-72
SRC	-41
ADM	-8
NET1	5
ARHGEF3	95
ARHGEF19	110
ITPR2	190
PTGER4	218
PDE4B	256
AHCYL1	266
CAMKK2	293
ADCY4	377
PDPK1	444
S1PR4	462
PRKACA	480
RGS12	578
NMB	609
ARHGEF2	630
GRK6	674
PRKAR2A	771
PIK3R2	866
NBEA	1043
ARRB1	1072
PDE7A	1143
HEBP1	1145
FZD6	1146
PRKACB	1167
ABHD6	1184
ABR	1302
S1PR1	1379
GNB4	1400
PTCH1	1422
GNRHR2	1442
AKAP13	1475
RASGRP1	1725
ITPR3	1758
CAMK4	1835
OPN3	1925
ARHGEF1	1999
TIAM2	2047
WNT3A	2069
DGKZ	2151
WNT1	2206
PIK3R5	2231
HRAS	2241
LPAR2	2278
VIPR1	2293
RASGRP2	2303
CCR1	2327
PRKCQ	2375
PIK3R1	2531
CXCR4	2548
CALM1	2569
PSAP	2609
RHOA	2719
ADCY9	2727
PDE8A	2787
GNB2	2806
PPP2CA	2847
CDK5	2882
GABBR1	2909
PAK1	2913
P2RY1	2965
RPS6KA2	3010
S1PR2	3017
HBEGF	3061
DGKE	3157
MAPK1	3217
GNA12	3221
DGKD	3364
FZD7	3401
PTGER2	3427
GPSM3	3428
GRB2	3473
CXCL2	3477
PRKCA	3486
RHOB	3615
DAGLB	3624
GNAI2	3664
ARHGEF17	3784
KPNA2	3922
ECE1	4068
GPR65	4124
RGS2	4139
PIK3R3	4166
GPR68	4268
ROCK1	4490
FZD3	4702
GNAL	4827
LPAR6	4851
RGS16	4985
FGD3	4989
ADRB2	5003
P2RY2	5020
MAPK7	5187
ECE2	5214
ARRB2	5233
PPP1CA	5270
PPP3CB	5366
GNAS	5417
AKT2	5440
CCR7	5458
PDE3B	5481
FZD5	5557
CHRM3	5585
TAS1R1	5619
PRKCH	5663
PLEKHG2	5723
CCR10	5933
GNB5	6045
ABHD12	6068
VAV1	6303
WNT2B	6349
PPP2R5D	6390
FZD2	6411
C3AR1	6596
GRK5	6616
ITSN1	6622
ARHGEF7	6761
GNG4	6944
RGS10	6949
GPR132	6966
CAMK2G	6968
RGS14	7041
PRKAR1B	7076
ITPR1	7110
GNAQ	7124
PIK3CA	7235
SOS2	7347
OBSCN	7381
GNG5	7410
GNA13	7515
GPSM2	7557
PDE4C	7643
DGKQ	7702
VAV2	7749
GNAI3	7816
PPP2R1B	7877
GNG2	7887
LTB4R	8014
MAPK3	8081
PIK3CG	8093
PROK2	8148
LTB4R2	8255
CNR2	8263
NTSR1	8294
CCL27	8403
PTCH2	8406

Mitochondrial translation elongation

Mitochondrial translation elongation
	535
set	Mitochondrial translation elongation
setSize	81
pANOVA	0.000664
s.dist	0.219
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
MRPL47	8226
AURKAIP1	8219
OXA1L	8131
MRPS21	8122
PTCD3	8109
MRPL30	8047
MRPL19	8025
MRPS33	7992
MRPS31	7966
ERAL1	7911
MRPS10	7836
GADD45GIP1	7827
MRPL42	7815
MRPL27	7736
MRPL10	7697
MRPS11	7667
DAP3	7632
TUFM	7516
MRPL39	7494
MRPS27	7438

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
MRPL47	8226
AURKAIP1	8219
OXA1L	8131
MRPS21	8122
PTCD3	8109
MRPL30	8047
MRPL19	8025
MRPS33	7992
MRPS31	7966
ERAL1	7911
MRPS10	7836
GADD45GIP1	7827
MRPL42	7815
MRPL27	7736
MRPL10	7697
MRPS11	7667
DAP3	7632
TUFM	7516
MRPL39	7494
MRPS27	7438
MRPL37	7358
MRPL55	7303
CHCHD1	7269
MRPL13	7092
MRPS16	7028
MRPL1	7006
MRPL35	6889
MRPL2	6617
MRPL46	6439
TSFM	6415
MRPS30	6402
MRPL54	6395
MRPS36	6353
MRPL20	6209
MRPS26	6194
MRPS23	5857
MRPL12	5591
MRPS12	5286
MRPL22	5218
MRPL24	5181
MRPL52	5168
MRPS17	5154
MRPL48	5073
MRPL45	4727
MRPL44	4705
MRPS18B	4629
MRPS28	4382
MRPL32	4062
MRPL49	4037
MRPS18A	3867
MRPL34	3831
MRPS18C	3802
MRPS9	3510
MRPS2	2764
MRPS5	2651
MRPL33	2630
MRPL18	2600
MRPS15	2580
MRPL15	2411
MRPS22	2055
MRPS34	1675
GFM1	1669
MRPL51	1507
MRPL23	1446
MRPS14	1431
MRPS25	1033
MRPL14	990
MRPS35	902
MRPL4	787
MRPS6	774
MRPL53	726
MRPS7	442
MRPL11	147
MRPL41	-27
MRPS24	-87
MRPL21	-102
MRPL38	-142
MRPL36	-314
MRPL50	-611
MRPL43	-1040
MRPL16	-1346

Integrin cell surface interactions

Integrin cell surface interactions
	426
set	Integrin cell surface interactions
setSize	23
pANOVA	0.000716
s.dist	-0.408
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
CD47	-1421
BSG	-1060
AGRN	-920
ITGA6	-618
ITGA2	-602
ITGB2	-332
ITGA5	-224
ITGB8	-130
JAM2	126
COL23A1	225
ITGB7	716
COL9A2	965
CD44	1077
ITGAE	1222
ICAM1	1618
ITGA1	1650
F11R	1739
ICAM3	1824
ICAM5	3744
ITGAV	5171

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
CD47	-1421
BSG	-1060
AGRN	-920
ITGA6	-618
ITGA2	-602
ITGB2	-332
ITGA5	-224
ITGB8	-130
JAM2	126
COL23A1	225
ITGB7	716
COL9A2	965
CD44	1077
ITGAE	1222
ICAM1	1618
ITGA1	1650
F11R	1739
ICAM3	1824
ICAM5	3744
ITGAV	5171
ICAM2	6266
ITGA4	6534
ITGAL	6648

Peptide chain elongation

Peptide chain elongation
	649
set	Peptide chain elongation
setSize	64
pANOVA	0.00075
s.dist	0.244
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
RPL32	6861
RPL37A	6591

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
RPL32	6861
RPL37A	6591
RPS23	6550
RPL23	6505
RPL37	6405
RPS16	6351
EEF2	5988
RPS10	5908
RPS18	5632
RPL27A	5614
RPS8	5562
UBA52	5448
RPL29	5290
RPS29	5166
RPL22	5041
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
RPL11	4330
RPS27L	4151
EEF1A1	3605
RPL31	3555
RPLP1	3408
RPS12	3328
RPLP0	3049
RPS26	2822
RPS19	2666
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
RPL35	1903
RPLP2	1447
RPS5	1210
RPS15	1135
RPL23A	1098
RPL39L	485
RPL13	339
FAU	233
RPS15A	72
RPL8	-295
RPL10A	-562
RPL36AL	-1188

rRNA processing

rRNA processing
	1134
set	rRNA processing
setSize	149
pANOVA	0.000796
s.dist	0.16
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
PES1	8341
RPS25	8288
DDX47	8287
RPS27A	8228
RCL1	8222
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
CSNK1E	7983
RPL34	7954
RPL3	7916
WBSCR22	7872
FBL	7793
RPL15	7772
RIOK2	7755
UTP20	7701
GAR1	7687

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
PES1	8341
RPS25	8288
DDX47	8287
RPS27A	8228
RCL1	8222
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
CSNK1E	7983
RPL34	7954
RPL3	7916
WBSCR22	7872
FBL	7793
RPL15	7772
RIOK2	7755
UTP20	7701
GAR1	7687
RPL28	7634
RPP30	7603
C1D	7585
BYSL	7563
WDR75	7541
RPS20	7538
ELAC2	7506
RPL38	7481
WDR18	7463
RPL9	7462
UTP6	7403
DDX52	7367
RPL41	7287
RPL26	7225
THUMPD1	7215
RPL26L1	7153
EXOSC10	7129
RPP14	7012
RPL32	6861
DCAF13	6595
RPL37A	6591
RPS23	6550
RPL23	6505
FCF1	6479
RPL37	6405
LTV1	6380
RPS16	6351
MPHOSPH6	6246
EXOSC6	6042
RRP7A	5962
RPS10	5908
IMP4	5827
TBL3	5814
RPS18	5632
RPL27A	5614
RPS8	5562
NOP10	5553
UBA52	5448
WDR12	5442
RPL29	5290
RPS29	5166
PNO1	5053
WDR43	5052
RPL22	5041
UTP15	4993
NOL6	4802
SENP3	4693
EXOSC7	4662
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
NOB1	4405
IMP3	4395
RPL11	4330
PELP1	4290
PDCD11	4218
UTP3	4201
RPS27L	4151
FTSJ3	4146
NOL12	4088
HEATR1	3939
BMS1	3878
EBNA1BP2	3873
NSUN4	3736
MRM1	3590
RPL31	3555
EXOSC2	3525
DDX21	3469
EXOSC8	3443
RPLP1	3408
RPS12	3328
NOL11	3213
RPLP0	3049
RBM28	3026
DIS3	2928
XRN2	2897
TFB1M	2841
RPS26	2822
RPS19	2666
NOP14	2648
RIOK1	2384
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
WDR36	2073
RPL35	1903
RPP21	1823
NOP56	1724
RPLP2	1447
WDR3	1443
TSR1	1421
NOP58	1322
EXOSC4	1277
RRP1	1248
RPS5	1210
RIOK3	1192
TEX10	1160
RPS15	1135
CSNK1D	1107
RPL23A	1098
MPHOSPH10	1092
RRP9	1022
ISG20L2	997
RPP25	991
NOP2	904
NCL	872
RPP38	823
NIP7	820
DHX37	689
NOC4L	665
PWP2	608
EXOSC3	501
RPL39L	485
RPL13	339
NHP2	301
FAU	233
GNL3	216
RPS15A	72
RPL8	-295
DDX49	-412
RPP40	-457
EXOSC5	-485
RPL10A	-562
ERI1	-851
RPL36AL	-1188

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
	467
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	82
pANOVA	0.000839
s.dist	0.214
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
EIF4H	8386
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
EIF4A2	8016
RPS24	7985
EIF3K	7962
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
EIF4H	8386
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
EIF4A2	8016
RPS24	7985
EIF3K	7962
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
EIF2S1	6910
RPL32	6861
RPL37A	6591
RPS23	6550
RPL23	6505
EIF3A	6467
RPL37	6405
RPS16	6351
EIF3E	6310
EIF3B	6240
EIF4A1	5915
RPS10	5908
RPS18	5632
RPL27A	5614
PABPC1	5582
RPS8	5562
UBA52	5448
RPL29	5290
RPS29	5166
EIF3H	5136
RPL22	5041
EIF3F	4913
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
RPL11	4330
EIF2S2	4264
RPS27L	4151
RPL31	3555
RPLP1	3408
RPS12	3328
RPLP0	3049
RPS26	2822
EIF4B	2671
RPS19	2666
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
RPL35	1903
EIF4G1	1882
RPLP2	1447
EIF3J	1279
RPS5	1210
RPS15	1135
RPL23A	1098
EIF3L	880
RPL39L	485
RPL13	339
FAU	233
RPS15A	72
EIF3M	-129
EIF3G	-171
EIF3I	-201
RPL8	-295
RPL10A	-562
EIF4E	-590
RPL36AL	-1188

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
	337
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	83
pANOVA	0.000939
s.dist	0.211
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
EIF4H	8386
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
EIF4A2	8016
RPS24	7985
EIF3K	7962
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
EIF4H	8386
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
EIF4A2	8016
RPS24	7985
EIF3K	7962
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
EIF2S1	6910
RPL32	6861
RPL37A	6591
RPS23	6550
RPL23	6505
EIF3A	6467
RPL37	6405
RPS16	6351
EIF3E	6310
EIF3B	6240
EIF5B	5991
EIF4A1	5915
RPS10	5908
RPS18	5632
RPL27A	5614
RPS8	5562
UBA52	5448
RPL29	5290
RPS29	5166
EIF3H	5136
RPL22	5041
EIF3F	4913
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
RPL11	4330
EIF2S2	4264
RPS27L	4151
RPL31	3555
RPLP1	3408
RPS12	3328
RPLP0	3049
RPS26	2822
EIF5	2798
EIF4B	2671
RPS19	2666
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
RPL35	1903
EIF4G1	1882
RPLP2	1447
EIF3J	1279
RPS5	1210
RPS15	1135
RPL23A	1098
EIF3L	880
RPL39L	485
RPL13	339
FAU	233
RPS15A	72
EIF3M	-129
EIF3G	-171
EIF3I	-201
RPL8	-295
RPL10A	-562
EIF4E	-590
RPL36AL	-1188

NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus
	563
set	NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize	12
pANOVA	0.000967
s.dist	0.55
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
NCSTN	8369
RPS27A	8228
UBB	7418
APH1A	6905
PSEN1	6541
APH1B	6499
PSENEN	6061
UBC	5810
MIB1	5480
UBA52	5448
ADAM10	5018
PSEN2	2706

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
NCSTN	8369
RPS27A	8228
UBB	7418
APH1A	6905
PSEN1	6541
APH1B	6499
PSENEN	6061
UBC	5810
MIB1	5480
UBA52	5448
ADAM10	5018
PSEN2	2706

Signaling by ROBO receptors

Signaling by ROBO receptors
	951
set	Signaling by ROBO receptors
setSize	146
pANOVA	0.000979
s.dist	0.159
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
NCBP1	8402
RPS25	8288
PFN2	8238
ABL2	8234
RPS27A	8228
PSMA3	8188
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
PAK4	7768
RPL28	7634
PSMB5	7598
RPS20	7538
RPL38	7481

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
NCBP1	8402
RPS25	8288
PFN2	8238
ABL2	8234
RPS27A	8228
PSMA3	8188
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
PAK4	7768
RPL28	7634
PSMB5	7598
RPS20	7538
RPL38	7481
RPL9	7462
UBB	7418
SOS2	7347
RPL41	7287
PSMC1	7227
RPL26	7225
RPL26L1	7153
PSMA5	7049
PSMD12	7015
RPL32	6861
PSME2	6844
PSMB10	6829
NCBP2	6756
PSMB7	6667
RPL37A	6591
PSMB6	6558
RPS23	6550
PSMD11	6544
USP33	6511
RPL23	6505
RPL37	6405
CLASP2	6396
RPS16	6351
CAP1	6176
PSMC6	5996
RPS10	5908
ABL1	5899
UBC	5810
EIF4A3	5779
NTN1	5763
RPS18	5632
RPL27A	5614
PABPC1	5582
RPS8	5562
PSMB3	5497
LDB1	5453
UBA52	5448
PPP3CB	5366
PSMD4	5325
RPL29	5290
CLASP1	5253
PAK2	5230
RPS29	5166
PSMD7	5075
RPL22	5041
PSMB1	4974
EVL	4872
PSMF1	4670
PSMD1	4661
RPS9	4648
RPL6	4621
RPL36	4617
PSMD9	4605
RPS3A	4514
RPL17	4433
RPL11	4330
RPS27L	4151
CUL2	4094
PSME3	3994
NCK1	3798
PSMD14	3709
PSMD2	3621
RPL31	3555
PRKCA	3486
SRGAP1	3456
RPLP1	3408
RPS12	3328
PSMA6	3273
PSMC3	3247
PSMB9	3199
VASP	3146
RPLP0	3049
PSMD8	3011
PSMA7	2927
PAK1	2913
RPS26	2822
CASC3	2750
RHOA	2719
RPS19	2666
PSMD13	2662
RAC1	2583
CXCR4	2548
PSMD3	2545
UPF2	2503
PSMC5	2470
PSMD6	2403
RPS7	2356
RPL14	2209
RPS11	2201
RNPS1	2173
UPF3A	2172
RPL18	2150
RPL7	2139
PSMC4	2130
GSPT1	2009
RPL35	1903
EIF4G1	1882
PSMA1	1855
PFN1	1516
RPLP2	1447
PSMA2	1432
NCK2	1297
RPS5	1210
PRKACB	1167
RPS15	1135
MYO9B	1112
DAG1	1109
RPL23A	1098
PRKAR2A	771
PSMB8	756
RBX1	651
SRGAP3	586
RPL39L	485
PRKACA	480
RPL13	339
FAU	233
PSME1	209
PSME4	207
RPS15A	72
ETF1	-25
SRC	-41
RPL8	-295
RPL10A	-562
SLIT1	-672
CDC42	-1172
RPL36AL	-1188

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	601
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	69
pANOVA	0.000992
s.dist	0.23
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
NCBP1	8402
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
RPL32	6861

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
NCBP1	8402
RPS25	8288
RPS27A	8228
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
RPL34	7954
RPL3	7916
RPL15	7772
RPL28	7634
RPS20	7538
RPL38	7481
RPL9	7462
RPL41	7287
RPL26	7225
RPL26L1	7153
RPL32	6861
NCBP2	6756
RPL37A	6591
RPS23	6550
RPL23	6505
RPL37	6405
RPS16	6351
RPS10	5908
RPS18	5632
RPL27A	5614
PABPC1	5582
RPS8	5562
UBA52	5448
RPL29	5290
RPS29	5166
RPL22	5041
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
RPL11	4330
RPS27L	4151
RPL31	3555
UPF1	3538
RPLP1	3408
RPS12	3328
RPLP0	3049
RPS26	2822
RPS19	2666
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
GSPT1	2009
RPL35	1903
EIF4G1	1882
RPLP2	1447
RPS5	1210
RPS15	1135
RPL23A	1098
RPL39L	485
RPL13	339
FAU	233
RPS15A	72
ETF1	-25
RPL8	-295
RPL10A	-562
RPL36AL	-1188

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
	1135
set	rRNA processing in the nucleus and cytosol
setSize	145
pANOVA	0.000999
s.dist	0.159
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
PES1	8341
RPS25	8288
DDX47	8287
RPS27A	8228
RCL1	8222
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
CSNK1E	7983
RPL34	7954
RPL3	7916
WBSCR22	7872
FBL	7793
RPL15	7772
RIOK2	7755
UTP20	7701
GAR1	7687

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
PES1	8341
RPS25	8288
DDX47	8287
RPS27A	8228
RCL1	8222
RPS3	8185
RPS6	8168
RPS28	8167
RPL4	8137
RPSA	8071
RPS24	7985
CSNK1E	7983
RPL34	7954
RPL3	7916
WBSCR22	7872
FBL	7793
RPL15	7772
RIOK2	7755
UTP20	7701
GAR1	7687
RPL28	7634
RPP30	7603
C1D	7585
BYSL	7563
WDR75	7541
RPS20	7538
RPL38	7481
WDR18	7463
RPL9	7462
UTP6	7403
DDX52	7367
RPL41	7287
RPL26	7225
THUMPD1	7215
RPL26L1	7153
EXOSC10	7129
RPP14	7012
RPL32	6861
DCAF13	6595
RPL37A	6591
RPS23	6550
RPL23	6505
FCF1	6479
RPL37	6405
LTV1	6380
RPS16	6351
MPHOSPH6	6246
EXOSC6	6042
RRP7A	5962
RPS10	5908
IMP4	5827
TBL3	5814
RPS18	5632
RPL27A	5614
RPS8	5562
NOP10	5553
UBA52	5448
WDR12	5442
RPL29	5290
RPS29	5166
PNO1	5053
WDR43	5052
RPL22	5041
UTP15	4993
NOL6	4802
SENP3	4693
EXOSC7	4662
RPS9	4648
RPL6	4621
RPL36	4617
RPS3A	4514
RPL17	4433
NOB1	4405
IMP3	4395
RPL11	4330
PELP1	4290
PDCD11	4218
UTP3	4201
RPS27L	4151
FTSJ3	4146
NOL12	4088
HEATR1	3939
BMS1	3878
EBNA1BP2	3873
RPL31	3555
EXOSC2	3525
DDX21	3469
EXOSC8	3443
RPLP1	3408
RPS12	3328
NOL11	3213
RPLP0	3049
RBM28	3026
DIS3	2928
XRN2	2897
RPS26	2822
RPS19	2666
NOP14	2648
RIOK1	2384
RPS7	2356
RPL14	2209
RPS11	2201
RPL18	2150
RPL7	2139
WDR36	2073
RPL35	1903
RPP21	1823
NOP56	1724
RPLP2	1447
WDR3	1443
TSR1	1421
NOP58	1322
EXOSC4	1277
RRP1	1248
RPS5	1210
RIOK3	1192
TEX10	1160
RPS15	1135
CSNK1D	1107
RPL23A	1098
MPHOSPH10	1092
RRP9	1022
ISG20L2	997
RPP25	991
NOP2	904
NCL	872
RPP38	823
NIP7	820
DHX37	689
NOC4L	665
PWP2	608
EXOSC3	501
RPL39L	485
RPL13	339
NHP2	301
FAU	233
GNL3	216
RPS15A	72
RPL8	-295
DDX49	-412
RPP40	-457
EXOSC5	-485
RPL10A	-562
ERI1	-851
RPL36AL	-1188

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.0 (2021-05-18)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/liblapack.so.3
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.1                                      
##  [2] GGally_2.1.1                                       
##  [3] ggplot2_3.3.3                                      
##  [4] gtools_3.8.2                                       
##  [5] tibble_3.1.2                                       
##  [6] dplyr_1.0.6                                        
##  [7] echarts4r_0.4.0                                    
##  [8] ENmix_1.25.1                                       
##  [9] doParallel_1.0.16                                  
## [10] qqman_0.1.8                                        
## [11] RCircos_1.2.1                                      
## [12] DMRcatedata_2.6.0                                  
## [13] ExperimentHub_1.14.2                               
## [14] AnnotationHub_2.20.2                               
## [15] BiocFileCache_1.12.1                               
## [16] dbplyr_2.1.1                                       
## [17] beeswarm_0.3.1                                     
## [18] reshape2_1.4.4                                     
## [19] gplots_3.1.1                                       
## [20] eulerr_6.1.0                                       
## [21] R.utils_2.10.1                                     
## [22] R.oo_1.24.0                                        
## [23] R.methodsS3_1.8.1                                  
## [24] plyr_1.8.6                                         
## [25] RColorBrewer_1.1-2                                 
## [26] forestplot_1.10.1                                  
## [27] checkmate_2.0.0                                    
## [28] magrittr_2.0.1                                     
## [29] kableExtra_1.3.4                                   
## [30] mitch_1.0.10                                       
## [31] DMRcate_2.2.3                                      
## [32] IlluminaHumanMethylation450kmanifest_0.4.0         
## [33] topconfects_1.4.0                                  
## [34] limma_3.44.3                                       
## [35] GEOquery_2.56.0                                    
## [36] missMethyl_1.22.0                                  
## [37] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [38] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.0 
## [39] minfi_1.34.0                                       
## [40] bumphunter_1.30.0                                  
## [41] locfit_1.5-9.4                                     
## [42] iterators_1.0.13                                   
## [43] foreach_1.5.1                                      
## [44] Biostrings_2.56.0                                  
## [45] XVector_0.28.0                                     
## [46] SummarizedExperiment_1.18.2                        
## [47] DelayedArray_0.14.1                                
## [48] matrixStats_0.58.0                                 
## [49] Biobase_2.48.0                                     
## [50] GenomicRanges_1.40.0                               
## [51] GenomeInfoDb_1.24.2                                
## [52] IRanges_2.22.2                                     
## [53] S4Vectors_0.26.1                                   
## [54] BiocGenerics_0.34.0                                
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.48.0           
##   [3] tidyr_1.1.3                   bit64_4.0.5                  
##   [5] knitr_1.33                    data.table_1.14.0            
##   [7] rpart_4.1-15                  RCurl_1.98-1.3               
##   [9] AnnotationFilter_1.12.0       generics_0.1.0               
##  [11] GenomicFeatures_1.40.1        preprocessCore_1.50.0        
##  [13] RSQLite_2.2.7                 bit_4.0.4                    
##  [15] webshot_0.5.2                 xml2_1.3.2                   
##  [17] httpuv_1.6.1                  assertthat_0.2.1             
##  [19] xfun_0.23                     hms_1.1.0                    
##  [21] jquerylib_0.1.4               evaluate_0.14                
##  [23] promises_1.2.0.1              fansi_0.4.2                  
##  [25] scrime_1.3.5                  progress_1.2.2               
##  [27] caTools_1.18.2                readxl_1.3.1                 
##  [29] DBI_1.1.1                     geneplotter_1.66.0           
##  [31] htmlwidgets_1.5.3             reshape_0.8.8                
##  [33] purrr_0.3.4                   ellipsis_0.3.2               
##  [35] backports_1.2.1               permute_0.9-5                
##  [37] calibrate_1.7.7               annotate_1.66.0              
##  [39] biomaRt_2.44.4                vctrs_0.3.8                  
##  [41] ensembldb_2.12.1              withr_2.4.2                  
##  [43] cachem_1.0.5                  Gviz_1.32.0                  
##  [45] BSgenome_1.56.0               GenomicAlignments_1.24.0     
##  [47] prettyunits_1.1.1             mclust_5.4.7                 
##  [49] svglite_2.0.0                 cluster_2.1.2                
##  [51] RPMM_1.25                     lazyeval_0.2.2               
##  [53] crayon_1.4.1                  genefilter_1.70.0            
##  [55] labeling_0.4.2                edgeR_3.30.3                 
##  [57] pkgconfig_2.0.3               nlme_3.1-152                 
##  [59] ProtGenerics_1.20.0           nnet_7.3-16                  
##  [61] rlang_0.4.11                  lifecycle_1.0.0              
##  [63] dichromat_2.0-0               rprojroot_2.0.2              
##  [65] cellranger_1.1.0              rngtools_1.5                 
##  [67] base64_2.0                    Matrix_1.3-3                 
##  [69] Rhdf5lib_1.10.1               base64enc_0.1-3              
##  [71] png_0.1-7                     viridisLite_0.4.0            
##  [73] bitops_1.0-7                  KernSmooth_2.23-20           
##  [75] blob_1.2.1                    DelayedMatrixStats_1.10.1    
##  [77] doRNG_1.8.2                   stringr_1.4.0                
##  [79] nor1mix_1.3-0                 readr_1.4.0                  
##  [81] jpeg_0.1-8.1                  scales_1.1.1                 
##  [83] lpSolve_5.6.15                memoise_2.0.0                
##  [85] zlibbioc_1.34.0               compiler_4.1.0               
##  [87] illuminaio_0.30.0             Rsamtools_2.4.0              
##  [89] DSS_2.36.0                    htmlTable_2.2.1              
##  [91] Formula_1.2-4                 MASS_7.3-54                  
##  [93] tidyselect_1.1.1              stringi_1.6.2                
##  [95] highr_0.9                     yaml_2.2.1                   
##  [97] askpass_1.1                   latticeExtra_0.6-29          
##  [99] sass_0.4.0                    VariantAnnotation_1.34.0     
## [101] tools_4.1.0                   rstudioapi_0.13              
## [103] foreign_0.8-81                bsseq_1.24.4                 
## [105] gridExtra_2.3                 farver_2.1.0                 
## [107] digest_0.6.27                 BiocManager_1.30.15          
## [109] shiny_1.6.0                   quadprog_1.5-8               
## [111] Rcpp_1.0.6                    siggenes_1.62.0              
## [113] BiocVersion_3.11.1            later_1.2.0                  
## [115] org.Hs.eg.db_3.11.4           httr_1.4.2                   
## [117] AnnotationDbi_1.50.3          biovizBase_1.36.0            
## [119] colorspace_2.0-1              rvest_1.0.0                  
## [121] XML_3.99-0.6                  splines_4.1.0                
## [123] statmod_1.4.36                multtest_2.44.0              
## [125] irr_0.84.1                    systemfonts_1.0.2            
## [127] xtable_1.8-4                  jsonlite_1.7.2               
## [129] dynamicTreeCut_1.63-1         testthat_3.0.2               
## [131] R6_2.5.0                      Hmisc_4.5-0                  
## [133] pillar_1.6.1                  htmltools_0.5.1.1            
## [135] mime_0.10                     glue_1.4.2                   
## [137] fastmap_1.1.0                 BiocParallel_1.22.0          
## [139] interactiveDisplayBase_1.26.3 beanplot_1.2                 
## [141] codetools_0.2-18              utf8_1.2.1                   
## [143] lattice_0.20-44               bslib_0.2.5.1                
## [145] curl_4.3.1                    openssl_1.4.4                
## [147] survival_3.2-11               rmarkdown_2.8                
## [149] desc_1.3.0                    munsell_0.5.0                
## [151] rhdf5_2.32.4                  GenomeInfoDbData_1.2.3       
## [153] HDF5Array_1.16.1              impute_1.62.0                
## [155] gtable_0.3.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports