date generated: 2021-05-25

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                 t
## A1BG  -0.73738014
## AAAS   0.26769161
## AACS  -0.05724519
## AAGAB  1.40287399
## AAK1  -0.23257636
## AAMP   1.76955365
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2484
num_genes_in_profile 9869
duplicated_genes_present 0
num_profile_genes_in_sets 5319
num_profile_genes_not_in_sets 4550

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2484
num_genesets_excluded 1343
num_genesets_included 1141

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 20 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Cell Cycle 482 0.000031 0.1120 0.0353
Transmission across Chemical Synapses 93 0.000130 -0.2300 0.0498
Neuronal System 127 0.000157 -0.1950 0.0498
Neurotransmitter release cycle 18 0.000175 -0.5110 0.0498
Cell Cycle, Mitotic 390 0.000277 0.1080 0.0589
Metabolism of RNA 498 0.000388 0.0942 0.0589
Cytokine Signaling in Immune system 411 0.000394 0.1030 0.0589
Immune System 1091 0.000415 0.0654 0.0589
Infectious disease 507 0.000465 0.0921 0.0589
M Phase 272 0.001140 0.1150 0.1290
Activation of NMDA receptors and postsynaptic events 43 0.001510 -0.2800 0.1290
SARS-CoV Infections 109 0.001570 0.1760 0.1290
Arachidonic acid metabolism 21 0.001610 -0.3980 0.1290
Integrin signaling 16 0.001690 0.4540 0.1290
Platelet Aggregation (Plug Formation) 16 0.001690 0.4540 0.1290
Regulation of FZD by ubiquitination 12 0.002600 -0.5020 0.1740
Maturation of nucleoprotein 10 0.002680 0.5480 0.1740
Chromatin modifying enzymes 137 0.003030 0.1470 0.1740
Chromatin organization 137 0.003030 0.1470 0.1740
G2/M Transition 143 0.003050 0.1440 0.1740


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Cell Cycle 482 0.000031 1.12e-01 0.0353
Transmission across Chemical Synapses 93 0.000130 -2.30e-01 0.0498
Neuronal System 127 0.000157 -1.95e-01 0.0498
Neurotransmitter release cycle 18 0.000175 -5.11e-01 0.0498
Cell Cycle, Mitotic 390 0.000277 1.08e-01 0.0589
Metabolism of RNA 498 0.000388 9.42e-02 0.0589
Cytokine Signaling in Immune system 411 0.000394 1.03e-01 0.0589
Immune System 1091 0.000415 6.54e-02 0.0589
Infectious disease 507 0.000465 9.21e-02 0.0589
M Phase 272 0.001140 1.15e-01 0.1290
Activation of NMDA receptors and postsynaptic events 43 0.001510 -2.80e-01 0.1290
SARS-CoV Infections 109 0.001570 1.76e-01 0.1290
Arachidonic acid metabolism 21 0.001610 -3.98e-01 0.1290
Integrin signaling 16 0.001690 4.54e-01 0.1290
Platelet Aggregation (Plug Formation) 16 0.001690 4.54e-01 0.1290
Regulation of FZD by ubiquitination 12 0.002600 -5.02e-01 0.1740
Maturation of nucleoprotein 10 0.002680 5.48e-01 0.1740
Chromatin modifying enzymes 137 0.003030 1.47e-01 0.1740
Chromatin organization 137 0.003030 1.47e-01 0.1740
G2/M Transition 143 0.003050 1.44e-01 0.1740
HATs acetylate histones 53 0.004160 2.28e-01 0.2210
Glutamate Neurotransmitter Release Cycle 11 0.004340 -4.97e-01 0.2210
Mitotic G2-G2/M phases 145 0.004460 1.37e-01 0.2210
Cellular responses to stress 425 0.005160 8.01e-02 0.2450
RNA Polymerase II Transcription Termination 35 0.005940 2.69e-01 0.2660
Cellular responses to external stimuli 430 0.006070 7.81e-02 0.2660
Neurotransmitter receptors and postsynaptic signal transmission 73 0.007150 -1.82e-01 0.2990
Transcriptional regulation of granulopoiesis 24 0.007340 -3.16e-01 0.2990
PIP3 activates AKT signaling 172 0.007890 1.18e-01 0.2990
HSP90 chaperone cycle for steroid hormone receptors (SHR) 32 0.007950 2.71e-01 0.2990
Post NMDA receptor activation events 37 0.008210 -2.51e-01 0.2990
Heparan sulfate/heparin (HS-GAG) metabolism 19 0.008390 -3.49e-01 0.2990
Mitotic Prometaphase 146 0.008720 1.26e-01 0.3010
Dopamine Neurotransmitter Release Cycle 10 0.009650 -4.73e-01 0.3240
PKA-mediated phosphorylation of CREB 11 0.010800 -4.44e-01 0.3270
mRNA 3’-end processing 28 0.011000 2.78e-01 0.3270
HDACs deacetylate histones 26 0.011100 2.88e-01 0.3270
Regulation of expression of SLITs and ROBOs 117 0.011300 1.36e-01 0.3270
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 0.011300 -4.63e-01 0.3270
PKA activation 10 0.011600 -4.61e-01 0.3270
Processing of Capped Intronless Pre-mRNA 21 0.011700 3.18e-01 0.3270
Processing of Capped Intron-Containing Pre-mRNA 175 0.012800 1.10e-01 0.3470
PTEN Regulation 105 0.013300 1.40e-01 0.3470
Stimuli-sensing channels 35 0.013400 -2.42e-01 0.3470
SARS-CoV-1 Infection 41 0.014200 2.22e-01 0.3610
HCMV Infection 67 0.016100 1.70e-01 0.3910
Signaling by Interleukins 256 0.016400 8.78e-02 0.3910
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 15 0.017600 -3.54e-01 0.3910
Disease 900 0.017800 4.78e-02 0.3910
Interleukin-4 and Interleukin-13 signaling 47 0.017900 2.00e-01 0.3910
Diseases of carbohydrate metabolism 22 0.017900 -2.92e-01 0.3910
Class I peroxisomal membrane protein import 18 0.018500 3.21e-01 0.3910
Negative regulation of NMDA receptor-mediated neuronal transmission 11 0.018500 -4.10e-01 0.3910
mRNA Splicing - Major Pathway 129 0.018800 1.20e-01 0.3910
RUNX2 regulates osteoblast differentiation 13 0.019100 -3.75e-01 0.3910
Regulation of mRNA stability by proteins that bind AU-rich elements 73 0.019200 1.59e-01 0.3910
Processing of Intronless Pre-mRNAs 14 0.019500 3.61e-01 0.3910
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 81 0.021000 1.49e-01 0.4010
Nonsense-Mediated Decay (NMD) 81 0.021000 1.49e-01 0.4010
Assembly and cell surface presentation of NMDA receptors 12 0.021100 -3.85e-01 0.4010
Signaling by ERBB4 28 0.021800 -2.51e-01 0.4070
Signaling by Retinoic Acid 17 0.022500 -3.20e-01 0.4140
Interferon alpha/beta signaling 50 0.023400 1.86e-01 0.4140
Translation of structural proteins 26 0.024300 2.55e-01 0.4140
SARS-CoV-2 Infection 54 0.024500 1.77e-01 0.4140
Nicotinamide salvaging 10 0.025000 4.09e-01 0.4140
Fatty acid metabolism 96 0.025300 -1.32e-01 0.4140
RNA Polymerase III Transcription Initiation From Type 1 Promoter 24 0.026500 2.62e-01 0.4140
Translation 225 0.026700 8.63e-02 0.4140
mRNA decay by 3’ to 5’ exoribonuclease 13 0.027600 3.53e-01 0.4140
Mitotic Anaphase 185 0.027800 9.43e-02 0.4140
Mitotic Metaphase and Anaphase 186 0.027900 9.40e-02 0.4140
Intracellular signaling by second messengers 197 0.028000 9.13e-02 0.4140
Glycogen storage diseases 10 0.028000 -4.01e-01 0.4140
HCMV Early Events 48 0.028100 1.83e-01 0.4140
mRNA Splicing 137 0.028200 1.09e-01 0.4140
Cap-dependent Translation Initiation 90 0.028300 1.34e-01 0.4140
Eukaryotic Translation Initiation 90 0.028300 1.34e-01 0.4140
Ion channel transport 74 0.029000 -1.47e-01 0.4190
Metabolism of proteins 1217 0.030700 3.82e-02 0.4370
Purine catabolism 10 0.033200 3.89e-01 0.4670
Glycosaminoglycan metabolism 59 0.034400 -1.59e-01 0.4730
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 72 0.034700 1.44e-01 0.4730
Extension of Telomeres 41 0.034800 1.91e-01 0.4730
Assembly of collagen fibrils and other multimeric structures 10 0.036400 -3.82e-01 0.4890
Cell Cycle Checkpoints 212 0.037300 8.35e-02 0.4940
Regulation of pyruvate dehydrogenase (PDH) complex 11 0.038500 -3.60e-01 0.4980
Influenza Viral RNA Transcription and Replication 106 0.038700 1.17e-01 0.4980
Transport of small molecules 322 0.038800 -6.76e-02 0.4980
Long-term potentiation 10 0.039400 -3.76e-01 0.4980
Mitotic Prophase 69 0.039700 1.43e-01 0.4980
Cyclin A/B1/B2 associated events during G2/M transition 22 0.040200 2.53e-01 0.4990
Signal Transduction 1263 0.040800 3.56e-02 0.5000
RHO GTPases activate PKNs 26 0.042900 2.30e-01 0.5030
Neddylation 172 0.043000 8.99e-02 0.5030
RNA Polymerase III Transcription Initiation From Type 2 Promoter 23 0.043700 2.43e-01 0.5030
Gene Silencing by RNA 54 0.044500 1.58e-01 0.5030
Interleukin-2 family signaling 28 0.044800 2.19e-01 0.5030
Resolution of Sister Chromatid Cohesion 90 0.044900 1.23e-01 0.5030
Viral mRNA Translation 65 0.045400 1.44e-01 0.5030
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 14 0.045700 3.09e-01 0.5030
Telomere Maintenance 53 0.045800 1.59e-01 0.5030
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 0.045900 3.65e-01 0.5030
Transport of Mature Transcript to Cytoplasm 54 0.046600 1.57e-01 0.5030
Innate Immune System 582 0.047200 4.90e-02 0.5030
Respiratory electron transport 71 0.047200 1.36e-01 0.5030
G1/S Transition 106 0.047200 1.12e-01 0.5030
Potential therapeutics for SARS 56 0.048900 1.52e-01 0.5130
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 14 0.049000 3.04e-01 0.5130
SUMO E3 ligases SUMOylate target proteins 130 0.050100 9.99e-02 0.5160
Regulation of TP53 Activity through Acetylation 27 0.050200 2.18e-01 0.5160
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 69 0.052000 1.36e-01 0.5250
Complex I biogenesis 38 0.052000 1.82e-01 0.5250
Regulation of ornithine decarboxylase (ODC) 42 0.053000 1.73e-01 0.5260
Mitotic G1 phase and G1/S transition 121 0.053100 1.02e-01 0.5260
GPVI-mediated activation cascade 23 0.053900 2.32e-01 0.5260
Nuclear Events (kinase and transcription factor activation) 42 0.054300 1.72e-01 0.5260
NOTCH4 Intracellular Domain Regulates Transcription 14 0.054400 2.97e-01 0.5260
Diseases of metabolism 119 0.054800 -1.02e-01 0.5260
SRP-dependent cotranslational protein targeting to membrane 81 0.056300 1.23e-01 0.5330
SUMOylation 135 0.058100 9.48e-02 0.5330
E2F mediated regulation of DNA replication 12 0.058200 3.16e-01 0.5330
Cell-cell junction organization 12 0.058300 -3.16e-01 0.5330
Regulation of PTEN gene transcription 43 0.059200 1.67e-01 0.5330
Influenza Infection 123 0.059800 9.86e-02 0.5330
Nuclear Envelope Breakdown 45 0.060000 1.62e-01 0.5330
Anchoring of the basal body to the plasma membrane 70 0.060100 1.30e-01 0.5330
Polymerase switching on the C-strand of the telomere 20 0.060500 2.43e-01 0.5330
Estrogen-dependent gene expression 64 0.060800 1.36e-01 0.5330
Metabolism of fat-soluble vitamins 13 0.060900 -3.00e-01 0.5330
Metabolism of polyamines 46 0.061200 1.60e-01 0.5330
NGF-stimulated transcription 25 0.063100 2.15e-01 0.5380
RHO GTPases activate CIT 14 0.063100 2.87e-01 0.5380
TCR signaling 84 0.063300 1.17e-01 0.5380
COPI-independent Golgi-to-ER retrograde traffic 28 0.063700 2.03e-01 0.5380
RUNX2 regulates bone development 17 0.064400 -2.59e-01 0.5390
Transport of Mature mRNAs Derived from Intronless Transcripts 38 0.064700 1.73e-01 0.5390
Signaling by NOTCH4 67 0.066200 1.30e-01 0.5440
Eukaryotic Translation Elongation 67 0.067000 1.30e-01 0.5440
Gastrin-CREB signalling pathway via PKC and MAPK 11 0.067000 -3.19e-01 0.5440
Chaperonin-mediated protein folding 52 0.067500 1.47e-01 0.5440
Protein folding 58 0.067700 1.39e-01 0.5440
Diseases associated with O-glycosylation of proteins 20 0.071000 -2.33e-01 0.5650
Cell junction organization 22 0.071300 -2.22e-01 0.5650
Golgi-to-ER retrograde transport 91 0.073800 1.09e-01 0.5730
ROS and RNS production in phagocytes 22 0.074200 -2.20e-01 0.5730
KSRP (KHSRP) binds and destabilizes mRNA 14 0.074500 2.75e-01 0.5730
Leading Strand Synthesis 12 0.074800 2.97e-01 0.5730
Polymerase switching 12 0.074800 2.97e-01 0.5730
Signaling by the B Cell Receptor (BCR) 87 0.075400 1.11e-01 0.5730
Signaling by ROBO receptors 146 0.076400 8.53e-02 0.5750
Eukaryotic Translation Termination 66 0.077500 1.26e-01 0.5750
Formation of a pool of free 40S subunits 73 0.078000 1.20e-01 0.5750
Signaling by WNT in cancer 23 0.078200 -2.12e-01 0.5750
L13a-mediated translational silencing of Ceruloplasmin expression 82 0.078200 1.13e-01 0.5750
MAPK family signaling cascades 176 0.079400 7.70e-02 0.5750
Meiosis 39 0.080600 1.62e-01 0.5750
Peptide chain elongation 64 0.080700 1.26e-01 0.5750
Host Interactions of HIV factors 103 0.080900 9.98e-02 0.5750
Activation of ATR in response to replication stress 29 0.081100 1.87e-01 0.5750
G2/M Checkpoints 108 0.081200 9.74e-02 0.5750
Telomere Extension By Telomerase 19 0.081800 2.31e-01 0.5750
Nuclear Envelope (NE) Reassembly 56 0.082500 1.34e-01 0.5750
AURKA Activation by TPX2 51 0.082900 1.41e-01 0.5750
NOD1/2 Signaling Pathway 22 0.083100 2.14e-01 0.5750
Depolymerisation of the Nuclear Lamina 11 0.084400 3.01e-01 0.5800
Association of TriC/CCT with target proteins during biosynthesis 28 0.085700 1.88e-01 0.5800
DNA Damage/Telomere Stress Induced Senescence 24 0.085800 2.03e-01 0.5800
Transport of Mature mRNA Derived from an Intronless Transcript 37 0.085800 1.63e-01 0.5800
Adaptive Immune System 451 0.087000 4.76e-02 0.5840
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 16 0.089500 2.45e-01 0.5940
HCMV Late Events 47 0.090600 1.43e-01 0.5940
NRIF signals cell death from the nucleus 13 0.091100 -2.71e-01 0.5940
FCERI mediated Ca+2 mobilization 23 0.091900 2.03e-01 0.5940
Synaptic adhesion-like molecules 10 0.092800 -3.07e-01 0.5940
Condensation of Prometaphase Chromosomes 10 0.092900 3.07e-01 0.5940
Interferon Signaling 136 0.093700 8.36e-02 0.5940
Protein-protein interactions at synapses 31 0.094000 -1.74e-01 0.5940
Regulation of PLK1 Activity at G2/M Transition 63 0.094400 1.22e-01 0.5940
Regulation of KIT signaling 10 0.094700 3.05e-01 0.5940
GTP hydrolysis and joining of the 60S ribosomal subunit 83 0.095500 1.06e-01 0.5940
O-linked glycosylation 39 0.095600 -1.54e-01 0.5940
Nuclear Pore Complex (NPC) Disassembly 32 0.095700 1.70e-01 0.5940
RHOC GTPase cycle 45 0.096100 1.44e-01 0.5940
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 51 0.096300 1.35e-01 0.5940
Response of EIF2AK4 (GCN2) to amino acid deficiency 72 0.097300 1.13e-01 0.5970
Interleukin-12 family signaling 41 0.098900 1.49e-01 0.6040
Transcriptional Regulation by MECP2 28 0.103000 1.78e-01 0.6230
XBP1(S) activates chaperone genes 36 0.103000 1.57e-01 0.6240
CLEC7A (Dectin-1) signaling 81 0.104000 1.05e-01 0.6240
Intra-Golgi and retrograde Golgi-to-ER traffic 151 0.105000 7.67e-02 0.6240
Telomere C-strand (Lagging Strand) Synthesis 27 0.106000 1.80e-01 0.6240
Nuclear signaling by ERBB4 14 0.108000 -2.48e-01 0.6240
Separation of Sister Chromatids 141 0.109000 7.86e-02 0.6240
Carboxyterminal post-translational modifications of tubulin 19 0.109000 -2.12e-01 0.6240
Cellular Senescence 99 0.109000 9.35e-02 0.6240
ER Quality Control Compartment (ERQC) 18 0.109000 -2.18e-01 0.6240
RHO GTPase Effectors 184 0.111000 6.85e-02 0.6240
SUMOylation of ubiquitinylation proteins 35 0.112000 1.55e-01 0.6240
tRNA processing 82 0.112000 1.02e-01 0.6240
Centrosome maturation 56 0.113000 1.22e-01 0.6240
Recruitment of mitotic centrosome proteins and complexes 56 0.113000 1.22e-01 0.6240
Initiation of Nuclear Envelope (NE) Reformation 17 0.114000 2.22e-01 0.6240
Retinoid metabolism and transport 11 0.114000 -2.75e-01 0.6240
Downstream TCR signaling 69 0.114000 1.10e-01 0.6240
TP53 Regulates Transcription of Cell Cycle Genes 40 0.115000 1.44e-01 0.6240
Metabolism of carbohydrates 172 0.116000 -6.99e-02 0.6240
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 0.117000 1.71e-01 0.6240
S Phase 128 0.117000 8.05e-02 0.6240
tRNA processing in the nucleus 50 0.117000 1.28e-01 0.6240
RHOQ GTPase cycle 36 0.118000 -1.51e-01 0.6240
Branched-chain amino acid catabolism 19 0.118000 -2.07e-01 0.6240
Constitutive Signaling by AKT1 E17K in Cancer 23 0.119000 1.88e-01 0.6240
The NLRP3 inflammasome 12 0.120000 -2.59e-01 0.6240
Negative regulation of FGFR1 signaling 17 0.120000 -2.18e-01 0.6240
Negative regulation of FGFR2 signaling 17 0.120000 -2.18e-01 0.6240
Negative regulation of FGFR3 signaling 17 0.120000 -2.18e-01 0.6240
Negative regulation of FGFR4 signaling 17 0.120000 -2.18e-01 0.6240
Regulation of RUNX2 expression and activity 56 0.120000 1.20e-01 0.6240
PI3K/AKT Signaling in Cancer 50 0.120000 1.27e-01 0.6240
Neurexins and neuroligins 20 0.122000 -2.00e-01 0.6240
Transport of inorganic cations/anions and amino acids/oligopeptides 37 0.123000 -1.47e-01 0.6240
Cell recruitment (pro-inflammatory response) 15 0.123000 -2.30e-01 0.6240
Purinergic signaling in leishmaniasis infection 15 0.123000 -2.30e-01 0.6240
Interleukin receptor SHC signaling 15 0.123000 2.30e-01 0.6240
Unfolded Protein Response (UPR) 67 0.124000 1.09e-01 0.6240
Polo-like kinase mediated events 16 0.125000 2.22e-01 0.6240
Ca-dependent events 21 0.125000 -1.93e-01 0.6240
Loss of Nlp from mitotic centrosomes 48 0.128000 1.27e-01 0.6240
Loss of proteins required for interphase microtubule organization from the centrosome 48 0.128000 1.27e-01 0.6240
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 20 0.128000 1.97e-01 0.6240
Fc epsilon receptor (FCERI) signaling 103 0.128000 8.70e-02 0.6240
The citric acid (TCA) cycle and respiratory electron transport 109 0.129000 8.45e-02 0.6240
Gene expression (Transcription) 958 0.129000 2.98e-02 0.6240
Diseases associated with N-glycosylation of proteins 15 0.129000 2.26e-01 0.6240
Recruitment of NuMA to mitotic centrosomes 55 0.129000 1.18e-01 0.6240
SUMOylation of DNA damage response and repair proteins 65 0.130000 1.09e-01 0.6240
ESR-mediated signaling 106 0.131000 8.53e-02 0.6250
RAF/MAP kinase cascade 148 0.131000 7.23e-02 0.6250
Interleukin-12 signaling 35 0.132000 1.47e-01 0.6250
Pyruvate metabolism 19 0.133000 -1.99e-01 0.6260
Negative regulation of NOTCH4 signaling 47 0.133000 1.27e-01 0.6260
RHO GTPases Activate Formins 100 0.135000 8.68e-02 0.6300
Rap1 signalling 11 0.136000 2.60e-01 0.6300
Major pathway of rRNA processing in the nucleolus and cytosol 140 0.136000 7.33e-02 0.6300
APC-Cdc20 mediated degradation of Nek2A 21 0.136000 -1.88e-01 0.6300
MAPK1/MAPK3 signaling 153 0.137000 6.99e-02 0.6300
Platelet degranulation 46 0.137000 -1.27e-01 0.6300
Transport of Mature mRNA derived from an Intron-Containing Transcript 45 0.139000 1.28e-01 0.6300
Triglyceride catabolism 11 0.139000 -2.58e-01 0.6300
Autodegradation of the E3 ubiquitin ligase COP1 43 0.140000 1.30e-01 0.6300
GPCR downstream signalling 178 0.141000 -6.44e-02 0.6300
p53-Dependent G1 DNA Damage Response 55 0.141000 1.15e-01 0.6300
p53-Dependent G1/S DNA damage checkpoint 55 0.141000 1.15e-01 0.6300
Meiotic recombination 19 0.142000 1.95e-01 0.6300
Spry regulation of FGF signaling 15 0.142000 -2.19e-01 0.6300
GPCR ligand binding 71 0.142000 -1.01e-01 0.6300
rRNA processing in the nucleus and cytosol 145 0.142000 7.09e-02 0.6300
Cellular response to hypoxia 58 0.144000 1.11e-01 0.6330
Listeria monocytogenes entry into host cells 14 0.145000 -2.25e-01 0.6340
RNA polymerase II transcribes snRNA genes 62 0.145000 1.07e-01 0.6350
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 0.146000 1.56e-01 0.6370
VxPx cargo-targeting to cilium 15 0.147000 -2.16e-01 0.6370
RNA Polymerase III Transcription Initiation 32 0.148000 1.48e-01 0.6380
IRE1alpha activates chaperones 37 0.151000 1.37e-01 0.6460
CLEC7A (Dectin-1) induces NFAT activation 11 0.151000 2.50e-01 0.6460
DNA Replication Pre-Initiation 66 0.151000 1.02e-01 0.6460
Downstream signaling events of B Cell Receptor (BCR) 67 0.154000 1.01e-01 0.6510
MAPK6/MAPK4 signaling 64 0.155000 1.03e-01 0.6510
PLC beta mediated events 29 0.155000 -1.53e-01 0.6510
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 0.156000 2.12e-01 0.6510
TNFR2 non-canonical NF-kB pathway 65 0.156000 1.02e-01 0.6510
G alpha (i) signalling events 85 0.156000 -8.91e-02 0.6510
Regulation of TP53 Activity 130 0.157000 7.22e-02 0.6510
SUMOylation of SUMOylation proteins 30 0.157000 1.49e-01 0.6510
SLC-mediated transmembrane transport 90 0.158000 -8.64e-02 0.6520
Cargo trafficking to the periciliary membrane 38 0.160000 -1.32e-01 0.6580
ATF4 activates genes in response to endoplasmic reticulum stress 22 0.162000 1.72e-01 0.6660
EML4 and NUDC in mitotic spindle formation 85 0.165000 8.74e-02 0.6730
Selenocysteine synthesis 65 0.165000 9.97e-02 0.6730
Regulation of IFNA signaling 12 0.166000 2.31e-01 0.6730
Negative regulation of FLT3 13 0.166000 2.22e-01 0.6730
FOXO-mediated transcription 45 0.168000 1.19e-01 0.6760
Selenoamino acid metabolism 73 0.169000 9.34e-02 0.6770
Cell death signalling via NRAGE, NRIF and NADE 40 0.170000 -1.26e-01 0.6780
ECM proteoglycans 10 0.170000 -2.51e-01 0.6780
PERK regulates gene expression 25 0.171000 1.58e-01 0.6780
Formation of the beta-catenin:TCF transactivating complex 24 0.171000 1.61e-01 0.6780
Regulation of TP53 Activity through Phosphorylation 74 0.172000 9.20e-02 0.6800
Miscellaneous transport and binding events 14 0.174000 -2.10e-01 0.6810
Protein localization 113 0.174000 7.43e-02 0.6810
Regulation of innate immune responses to cytosolic DNA 11 0.174000 -2.37e-01 0.6810
Chromosome Maintenance 71 0.177000 9.29e-02 0.6850
Vitamin B5 (pantothenate) metabolism 11 0.179000 2.34e-01 0.6850
Calnexin/calreticulin cycle 23 0.179000 -1.62e-01 0.6850
Cellular response to starvation 107 0.180000 7.52e-02 0.6850
Synthesis of PC 21 0.181000 1.69e-01 0.6850
CaM pathway 20 0.181000 -1.73e-01 0.6850
Calmodulin induced events 20 0.181000 -1.73e-01 0.6850
rRNA processing 149 0.181000 6.37e-02 0.6850
Stabilization of p53 48 0.182000 1.12e-01 0.6850
Cholesterol biosynthesis 17 0.182000 -1.87e-01 0.6850
RNA Polymerase I Transcription Initiation 38 0.183000 1.25e-01 0.6850
Positive epigenetic regulation of rRNA expression 38 0.183000 1.25e-01 0.6850
Adrenaline,noradrenaline inhibits insulin secretion 11 0.183000 2.32e-01 0.6850
G alpha (s) signalling events 35 0.184000 -1.30e-01 0.6850
Epigenetic regulation of gene expression 70 0.186000 9.16e-02 0.6900
Activation of gene expression by SREBF (SREBP) 33 0.186000 -1.33e-01 0.6900
HIV Infection 177 0.188000 5.77e-02 0.6940
Transport of the SLBP Dependant Mature mRNA 31 0.191000 1.36e-01 0.7030
Signaling by GPCR 195 0.192000 -5.44e-02 0.7050
Mitochondrial iron-sulfur cluster biogenesis 10 0.195000 2.37e-01 0.7050
NOTCH3 Intracellular Domain Regulates Transcription 15 0.196000 1.93e-01 0.7050
Costimulation by the CD28 family 44 0.196000 1.13e-01 0.7050
Inflammasomes 16 0.196000 -1.87e-01 0.7050
RNA Polymerase III Abortive And Retractive Initiation 36 0.197000 1.24e-01 0.7050
RNA Polymerase III Transcription 36 0.197000 1.24e-01 0.7050
Apoptotic cleavage of cellular proteins 24 0.199000 1.52e-01 0.7050
Reproduction 43 0.199000 1.13e-01 0.7050
Metabolism of cofactors 17 0.200000 1.79e-01 0.7050
Amyloid fiber formation 27 0.201000 -1.42e-01 0.7050
Assembly Of The HIV Virion 13 0.201000 -2.05e-01 0.7050
Diseases of signal transduction by growth factor receptors and second messengers 261 0.203000 4.61e-02 0.7050
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 81 0.203000 8.20e-02 0.7050
Amplification of signal from the kinetochores 81 0.203000 8.20e-02 0.7050
RNA Polymerase II Pre-transcription Events 60 0.204000 9.50e-02 0.7050
Peptide ligand-binding receptors 19 0.204000 -1.68e-01 0.7050
Iron uptake and transport 37 0.204000 -1.21e-01 0.7050
G-protein mediated events 32 0.205000 -1.30e-01 0.7050
Transcriptional regulation by RUNX1 122 0.205000 6.67e-02 0.7050
RHOB GTPase cycle 40 0.206000 1.16e-01 0.7050
Activation of the pre-replicative complex 23 0.206000 1.52e-01 0.7050
MicroRNA (miRNA) biogenesis 17 0.208000 1.76e-01 0.7050
FOXO-mediated transcription of cell cycle genes 12 0.209000 2.09e-01 0.7050
Signaling by NTRK1 (TRKA) 79 0.210000 8.17e-02 0.7050
Triglyceride metabolism 16 0.211000 -1.81e-01 0.7050
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 45 0.211000 1.08e-01 0.7050
Thromboxane signalling through TP receptor 12 0.212000 2.08e-01 0.7050
FCGR3A-mediated IL10 synthesis 22 0.212000 -1.54e-01 0.7050
Golgi Associated Vesicle Biogenesis 37 0.215000 -1.18e-01 0.7050
Metabolism of water-soluble vitamins and cofactors 76 0.215000 8.24e-02 0.7050
Inactivation of APC/C via direct inhibition of the APC/C complex 16 0.215000 -1.79e-01 0.7050
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 16 0.215000 -1.79e-01 0.7050
Regulation of PTEN stability and activity 55 0.216000 9.67e-02 0.7050
DAP12 signaling 19 0.216000 1.64e-01 0.7050
Nuclear import of Rev protein 29 0.216000 1.33e-01 0.7050
Metabolism of non-coding RNA 43 0.216000 1.09e-01 0.7050
snRNP Assembly 43 0.216000 1.09e-01 0.7050
Nicotinate metabolism 16 0.217000 1.78e-01 0.7050
Formation of RNA Pol II elongation complex 43 0.217000 1.09e-01 0.7050
RNA Polymerase II Transcription Elongation 43 0.217000 1.09e-01 0.7050
Signaling by Insulin receptor 40 0.217000 -1.13e-01 0.7050
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 23 0.220000 1.48e-01 0.7060
Anti-inflammatory response favouring Leishmania parasite infection 51 0.220000 -9.95e-02 0.7060
Leishmania parasite growth and survival 51 0.220000 -9.95e-02 0.7060
Activation of NF-kappaB in B cells 54 0.221000 9.64e-02 0.7060
ROS sensing by NFE2L2 47 0.222000 1.03e-01 0.7060
Mitochondrial Fatty Acid Beta-Oxidation 24 0.224000 -1.43e-01 0.7060
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 47 0.225000 1.02e-01 0.7060
Recycling pathway of L1 15 0.226000 -1.81e-01 0.7060
Potassium Channels 23 0.227000 -1.46e-01 0.7060
Gap-filling DNA repair synthesis and ligation in TC-NER 54 0.227000 9.52e-02 0.7060
Lagging Strand Synthesis 17 0.227000 1.69e-01 0.7060
TBC/RABGAPs 39 0.228000 1.12e-01 0.7060
Elastic fibre formation 15 0.228000 -1.80e-01 0.7060
Glucagon signaling in metabolic regulation 16 0.228000 -1.74e-01 0.7060
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 30 0.228000 1.27e-01 0.7060
Downregulation of SMAD2/3:SMAD4 transcriptional activity 21 0.229000 -1.52e-01 0.7060
Ovarian tumor domain proteases 28 0.229000 -1.32e-01 0.7060
Sphingolipid de novo biosynthesis 18 0.230000 1.64e-01 0.7060
Response to elevated platelet cytosolic Ca2+ 50 0.230000 -9.83e-02 0.7060
Nucleotide salvage 18 0.230000 -1.63e-01 0.7060
Diseases of glycosylation 67 0.231000 -8.47e-02 0.7080
RUNX3 regulates p14-ARF 10 0.233000 -2.18e-01 0.7080
Basigin interactions 14 0.233000 1.84e-01 0.7080
Signaling by Rho GTPases 413 0.234000 3.46e-02 0.7090
G1/S DNA Damage Checkpoints 57 0.235000 9.10e-02 0.7120
Mitochondrial protein import 42 0.236000 1.06e-01 0.7140
Removal of the Flap Intermediate 12 0.242000 1.95e-01 0.7240
Signaling by NOTCH 128 0.243000 5.99e-02 0.7240
Bile acid and bile salt metabolism 14 0.244000 -1.80e-01 0.7240
Apoptotic execution phase 32 0.244000 1.19e-01 0.7240
Membrane binding and targetting of GAG proteins 11 0.244000 -2.03e-01 0.7240
Synthesis And Processing Of GAG, GAGPOL Polyproteins 11 0.244000 -2.03e-01 0.7240
FOXO-mediated transcription of cell death genes 14 0.245000 1.80e-01 0.7240
FCERI mediated NF-kB activation 61 0.245000 8.61e-02 0.7240
Interactions of Vpr with host cellular proteins 31 0.246000 1.21e-01 0.7240
Activated NOTCH1 Transmits Signal to the Nucleus 19 0.246000 -1.54e-01 0.7240
Transport of the SLBP independent Mature mRNA 30 0.247000 1.22e-01 0.7240
MAPK targets/ Nuclear events mediated by MAP kinases 22 0.250000 1.42e-01 0.7300
Transcriptional regulation by small RNAs 40 0.250000 1.05e-01 0.7300
Cyclin A:Cdk2-associated events at S phase entry 72 0.251000 7.83e-02 0.7320
RND1 GTPase cycle 29 0.254000 1.22e-01 0.7350
Chondroitin sulfate/dermatan sulfate metabolism 26 0.255000 -1.29e-01 0.7350
Growth hormone receptor signaling 17 0.256000 1.59e-01 0.7350
N-Glycan antennae elongation 11 0.256000 -1.98e-01 0.7350
Cross-presentation of soluble exogenous antigens (endosomes) 37 0.256000 1.08e-01 0.7350
Hyaluronan metabolism 10 0.256000 -2.07e-01 0.7350
Signaling by WNT 168 0.257000 5.09e-02 0.7360
Nucleobase catabolism 20 0.260000 1.45e-01 0.7410
Aquaporin-mediated transport 19 0.260000 -1.49e-01 0.7410
Caspase activation via extrinsic apoptotic signalling pathway 15 0.262000 1.67e-01 0.7450
AUF1 (hnRNP D0) binds and destabilizes mRNA 45 0.263000 9.65e-02 0.7450
NS1 Mediated Effects on Host Pathways 36 0.267000 1.07e-01 0.7530
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 425 0.267000 3.18e-02 0.7530
Vif-mediated degradation of APOBEC3G 42 0.270000 9.84e-02 0.7540
Removal of the Flap Intermediate from the C-strand 15 0.272000 1.64e-01 0.7540
Interactions of Rev with host cellular proteins 32 0.272000 1.12e-01 0.7540
Role of LAT2/NTAL/LAB on calcium mobilization 10 0.274000 2.00e-01 0.7540
Diseases associated with glycosylation precursor biosynthesis 18 0.274000 -1.49e-01 0.7540
Regulation of BACH1 activity 11 0.275000 -1.90e-01 0.7540
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 0.275000 -1.41e-01 0.7540
Neurodegenerative Diseases 20 0.275000 -1.41e-01 0.7540
C-type lectin receptors (CLRs) 97 0.275000 6.43e-02 0.7540
Myogenesis 13 0.276000 1.74e-01 0.7540
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 0.277000 1.62e-01 0.7540
DNA strand elongation 27 0.277000 1.21e-01 0.7540
Degradation of GLI2 by the proteasome 49 0.278000 8.97e-02 0.7540
GLI3 is processed to GLI3R by the proteasome 49 0.278000 8.97e-02 0.7540
HSF1-dependent transactivation 25 0.279000 1.25e-01 0.7540
Signaling by FGFR1 in disease 23 0.279000 -1.31e-01 0.7540
Defective pyroptosis 10 0.279000 1.98e-01 0.7540
Cargo concentration in the ER 19 0.282000 -1.43e-01 0.7600
Translation initiation complex formation 46 0.282000 9.17e-02 0.7600
AKT phosphorylates targets in the cytosol 13 0.284000 1.72e-01 0.7600
RET signaling 22 0.285000 -1.32e-01 0.7600
TP53 Regulates Transcription of Cell Death Genes 29 0.285000 -1.15e-01 0.7600
ER-Phagosome pathway 66 0.285000 7.62e-02 0.7600
Oxidative Stress Induced Senescence 51 0.287000 8.64e-02 0.7620
Pre-NOTCH Processing in Golgi 15 0.288000 1.59e-01 0.7620
Sema3A PAK dependent Axon repulsion 11 0.289000 -1.85e-01 0.7620
COPI-mediated anterograde transport 67 0.290000 7.49e-02 0.7620
Signaling by NTRKs 86 0.290000 6.62e-02 0.7620
Glutathione conjugation 20 0.290000 -1.37e-01 0.7620
Signaling by FGFR3 25 0.290000 -1.22e-01 0.7620
SUMOylation of DNA replication proteins 41 0.292000 9.53e-02 0.7620
Keratan sulfate/keratin metabolism 18 0.292000 -1.44e-01 0.7620
Class A/1 (Rhodopsin-like receptors) 44 0.293000 -9.17e-02 0.7640
Signaling by FGFR4 24 0.295000 -1.24e-01 0.7660
Signaling by VEGF 71 0.296000 7.19e-02 0.7660
Erythropoietin activates RAS 10 0.296000 -1.91e-01 0.7670
APC/C:Cdc20 mediated degradation of Cyclin B 19 0.302000 -1.37e-01 0.7780
FLT3 Signaling 32 0.302000 1.06e-01 0.7780
FCGR3A-mediated phagocytosis 41 0.305000 9.28e-02 0.7790
Leishmania phagocytosis 41 0.305000 9.28e-02 0.7790
Parasite infection 41 0.305000 9.28e-02 0.7790
ADORA2B mediated anti-inflammatory cytokines production 30 0.307000 -1.08e-01 0.7810
Generation of second messenger molecules 16 0.307000 1.47e-01 0.7810
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 26 0.308000 1.16e-01 0.7810
Regulation of Glucokinase by Glucokinase Regulatory Protein 26 0.308000 1.16e-01 0.7810
CD209 (DC-SIGN) signaling 15 0.310000 -1.51e-01 0.7850
mRNA Splicing - Minor Pathway 42 0.311000 9.05e-02 0.7850
Lysosome Vesicle Biogenesis 24 0.313000 -1.19e-01 0.7860
Regulation of signaling by CBL 14 0.313000 1.56e-01 0.7860
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 13 0.314000 -1.61e-01 0.7860
Formation of Incision Complex in GG-NER 36 0.315000 -9.69e-02 0.7860
Golgi Cisternae Pericentriolar Stack Reorganization 13 0.315000 1.61e-01 0.7860
The role of GTSE1 in G2/M progression after G2 checkpoint 51 0.316000 8.12e-02 0.7870
Ubiquitin-dependent degradation of Cyclin D 43 0.317000 8.84e-02 0.7870
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 0.318000 -1.67e-01 0.7890
NEP/NS2 Interacts with the Cellular Export Machinery 28 0.322000 1.08e-01 0.7960
RUNX3 regulates NOTCH signaling 11 0.323000 1.72e-01 0.7960
HDMs demethylate histones 15 0.324000 1.47e-01 0.7960
DNA Replication 101 0.324000 5.69e-02 0.7960
Formation of the ternary complex, and subsequently, the 43S complex 39 0.326000 9.10e-02 0.7960
G beta:gamma signalling through PI3Kgamma 14 0.326000 1.52e-01 0.7960
DCC mediated attractive signaling 11 0.326000 1.71e-01 0.7960
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 0.327000 -1.79e-01 0.7960
alpha-linolenic acid (ALA) metabolism 10 0.327000 -1.79e-01 0.7960
Cobalamin (Cbl, vitamin B12) transport and metabolism 10 0.332000 1.77e-01 0.8030
Caspase activation via Death Receptors in the presence of ligand 10 0.333000 1.77e-01 0.8030
Viral Messenger RNA Synthesis 38 0.333000 9.09e-02 0.8030
Biological oxidations 74 0.334000 -6.51e-02 0.8030
Deadenylation-dependent mRNA decay 49 0.334000 7.98e-02 0.8030
Sealing of the nuclear envelope (NE) by ESCRT-III 16 0.334000 1.39e-01 0.8030
Orc1 removal from chromatin 55 0.336000 7.52e-02 0.8040
MTOR signalling 32 0.336000 9.84e-02 0.8040
LDL clearance 12 0.338000 -1.60e-01 0.8060
Rev-mediated nuclear export of HIV RNA 31 0.338000 9.94e-02 0.8060
Phase II - Conjugation of compounds 42 0.339000 -8.53e-02 0.8060
Cellular response to heat stress 75 0.340000 6.38e-02 0.8060
Beta-catenin independent WNT signaling 99 0.342000 5.54e-02 0.8060
NoRC negatively regulates rRNA expression 39 0.343000 8.79e-02 0.8060
RAB GEFs exchange GTP for GDP on RABs 56 0.343000 -7.34e-02 0.8060
RHOU GTPase cycle 24 0.344000 1.12e-01 0.8060
Ribosomal scanning and start codon recognition 46 0.344000 8.07e-02 0.8060
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 0.345000 1.58e-01 0.8060
Post-translational protein modification 860 0.345000 1.95e-02 0.8060
G2/M DNA damage checkpoint 51 0.345000 7.65e-02 0.8060
Platelet activation, signaling and aggregation 125 0.346000 4.89e-02 0.8060
Vpr-mediated nuclear import of PICs 30 0.348000 9.92e-02 0.8060
Signaling by Hippo 11 0.348000 -1.64e-01 0.8060
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 0.349000 -1.06e-01 0.8080
Keratan sulfate biosynthesis 14 0.350000 -1.44e-01 0.8080
Interleukin-10 signaling 13 0.355000 -1.48e-01 0.8170
G beta:gamma signalling through CDC42 10 0.356000 1.69e-01 0.8170
Cyclin E associated events during G1/S transition 70 0.356000 6.39e-02 0.8170
Programmed Cell Death 148 0.357000 4.40e-02 0.8170
Postmitotic nuclear pore complex (NPC) reformation 25 0.359000 1.06e-01 0.8170
DAP12 interactions 21 0.361000 1.15e-01 0.8170
Transcriptional Regulation by TP53 273 0.361000 3.24e-02 0.8170
Vasopressin regulates renal water homeostasis via Aquaporins 18 0.362000 -1.24e-01 0.8170
Regulation of actin dynamics for phagocytic cup formation 43 0.362000 8.04e-02 0.8170
Export of Viral Ribonucleoproteins from Nucleus 29 0.363000 9.76e-02 0.8170
NOTCH1 Intracellular Domain Regulates Transcription 37 0.364000 8.64e-02 0.8170
Insulin receptor recycling 16 0.364000 -1.31e-01 0.8170
Collagen formation 19 0.364000 -1.20e-01 0.8170
Cell-Cell communication 44 0.364000 -7.91e-02 0.8170
COPI-dependent Golgi-to-ER retrograde traffic 63 0.364000 6.62e-02 0.8170
Dual incision in TC-NER 55 0.366000 7.06e-02 0.8170
Regulation of activated PAK-2p34 by proteasome mediated degradation 41 0.366000 8.17e-02 0.8170
Insulin receptor signalling cascade 25 0.366000 -1.04e-01 0.8170
Senescence-Associated Secretory Phenotype (SASP) 39 0.367000 -8.35e-02 0.8170
Synthesis of bile acids and bile salts 13 0.370000 -1.44e-01 0.8200
L1CAM interactions 39 0.370000 -8.30e-02 0.8200
Organelle biogenesis and maintenance 184 0.372000 3.84e-02 0.8230
Mitochondrial tRNA aminoacylation 16 0.373000 1.29e-01 0.8240
Signaling by EGFR 35 0.376000 8.66e-02 0.8280
Plasma lipoprotein assembly, remodeling, and clearance 33 0.379000 -8.85e-02 0.8290
DAG and IP3 signaling 26 0.380000 -9.96e-02 0.8290
Degradation of DVL 47 0.380000 7.41e-02 0.8290
Processive synthesis on the C-strand of the telomere 17 0.381000 1.23e-01 0.8290
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 0.381000 1.10e-01 0.8290
Antiviral mechanism by IFN-stimulated genes 73 0.382000 5.93e-02 0.8290
Nervous system development 294 0.382000 2.99e-02 0.8290
Transport of Ribonucleoproteins into the Host Nucleus 28 0.382000 9.55e-02 0.8290
Antigen processing-Cross presentation 71 0.385000 5.97e-02 0.8340
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 61 0.386000 6.43e-02 0.8340
Downregulation of ERBB2 signaling 15 0.387000 -1.29e-01 0.8340
Synthesis of DNA 94 0.388000 5.17e-02 0.8340
RHO GTPase cycle 271 0.388000 3.07e-02 0.8340
SUMOylation of RNA binding proteins 40 0.389000 7.88e-02 0.8340
VEGFR2 mediated vascular permeability 21 0.390000 -1.09e-01 0.8340
NR1H2 and NR1H3-mediated signaling 24 0.391000 1.01e-01 0.8350
HDR through Single Strand Annealing (SSA) 32 0.392000 8.75e-02 0.8360
Mitotic Spindle Checkpoint 93 0.393000 5.14e-02 0.8360
Glyoxylate metabolism and glycine degradation 19 0.393000 -1.13e-01 0.8360
CD28 dependent PI3K/Akt signaling 18 0.395000 1.16e-01 0.8360
RHOH GTPase cycle 27 0.396000 9.45e-02 0.8360
Inhibition of DNA recombination at telomere 17 0.396000 1.19e-01 0.8360
Signaling by FLT3 ITD and TKD mutants 12 0.397000 -1.41e-01 0.8360
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 0.397000 -1.36e-01 0.8360
RHOF GTPase cycle 23 0.398000 1.02e-01 0.8360
Activation of BAD and translocation to mitochondria 14 0.401000 1.30e-01 0.8410
Vpu mediated degradation of CD4 43 0.404000 7.36e-02 0.8450
Transferrin endocytosis and recycling 18 0.405000 -1.13e-01 0.8450
MAP3K8 (TPL2)-dependent MAPK1/3 activation 13 0.405000 -1.33e-01 0.8450
Amino acid transport across the plasma membrane 16 0.406000 -1.20e-01 0.8450
Condensation of Prophase Chromosomes 12 0.407000 1.38e-01 0.8450
Processive synthesis on the lagging strand 13 0.407000 1.33e-01 0.8450
Intraflagellar transport 30 0.409000 8.73e-02 0.8460
RHO GTPases Activate WASPs and WAVEs 28 0.410000 9.01e-02 0.8470
RHOV GTPase cycle 22 0.411000 1.01e-01 0.8470
Degradation of beta-catenin by the destruction complex 67 0.413000 5.80e-02 0.8480
Role of phospholipids in phagocytosis 16 0.413000 1.18e-01 0.8480
Signaling by Erythropoietin 19 0.414000 -1.08e-01 0.8490
Citric acid cycle (TCA cycle) 19 0.417000 1.08e-01 0.8530
Interferon gamma signaling 53 0.417000 6.45e-02 0.8530
RNA Polymerase I Transcription Termination 23 0.419000 9.74e-02 0.8540
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 0.419000 -8.26e-02 0.8540
RNA Polymerase I Promoter Clearance 42 0.421000 7.18e-02 0.8550
RNA Polymerase I Transcription 42 0.421000 7.18e-02 0.8550
Apoptotic factor-mediated response 15 0.423000 -1.20e-01 0.8570
Peroxisomal protein import 45 0.425000 6.89e-02 0.8590
Signaling by FGFR1 27 0.426000 -8.86e-02 0.8590
Metabolism of vitamins and cofactors 105 0.426000 4.51e-02 0.8590
tRNA Aminoacylation 21 0.427000 1.00e-01 0.8600
Regulation of HSF1-mediated heat shock response 62 0.429000 5.82e-02 0.8610
PCNA-Dependent Long Patch Base Excision Repair 18 0.430000 1.08e-01 0.8610
Pyroptosis 17 0.431000 1.10e-01 0.8610
Regulation of RAS by GAPs 55 0.431000 6.15e-02 0.8610
Ephrin signaling 12 0.432000 -1.31e-01 0.8610
RHOBTB1 GTPase cycle 18 0.433000 -1.07e-01 0.8610
Transcriptional Regulation by VENTX 25 0.434000 -9.05e-02 0.8620
Apoptosis 128 0.435000 4.01e-02 0.8630
mRNA decay by 5’ to 3’ exoribonuclease 14 0.436000 -1.20e-01 0.8630
SCF-beta-TrCP mediated degradation of Emi1 46 0.438000 6.62e-02 0.8630
EGR2 and SOX10-mediated initiation of Schwann cell myelination 12 0.440000 1.29e-01 0.8630
Presynaptic phase of homologous DNA pairing and strand exchange 31 0.440000 8.01e-02 0.8630
Mismatch Repair 13 0.441000 1.24e-01 0.8630
Activation of HOX genes during differentiation 36 0.441000 7.43e-02 0.8630
Activation of anterior HOX genes in hindbrain development during early embryogenesis 36 0.441000 7.43e-02 0.8630
Platelet homeostasis 45 0.441000 -6.65e-02 0.8630
Glycogen synthesis 11 0.443000 -1.34e-01 0.8640
Sphingolipid metabolism 43 0.446000 6.72e-02 0.8640
Integrin cell surface interactions 23 0.448000 9.15e-02 0.8640
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 0.448000 1.10e-01 0.8640
RNA Polymerase II Transcription 856 0.450000 1.56e-02 0.8640
Negative epigenetic regulation of rRNA expression 40 0.451000 6.89e-02 0.8640
Cilium Assembly 134 0.452000 3.78e-02 0.8640
Regulation of RUNX3 expression and activity 48 0.452000 6.28e-02 0.8640
Aberrant regulation of mitotic exit in cancer due to RB1 defects 15 0.453000 -1.12e-01 0.8640
Attenuation phase 19 0.453000 9.95e-02 0.8640
RNA Polymerase III Chain Elongation 16 0.453000 1.08e-01 0.8640
Assembly of the pre-replicative complex 53 0.454000 5.96e-02 0.8640
Translesion synthesis by POLK 15 0.454000 1.12e-01 0.8640
Chaperone Mediated Autophagy 12 0.455000 -1.25e-01 0.8640
Diseases of DNA repair 10 0.455000 1.37e-01 0.8640
Late Phase of HIV Life Cycle 105 0.455000 4.23e-02 0.8640
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 56 0.456000 5.77e-02 0.8640
Disorders of transmembrane transporters 102 0.456000 4.28e-02 0.8640
Transcriptional regulation by RUNX3 73 0.456000 5.05e-02 0.8640
Regulation of cholesterol biosynthesis by SREBP (SREBF) 45 0.457000 -6.42e-02 0.8640
TICAM1-dependent activation of IRF3/IRF7 12 0.458000 -1.24e-01 0.8640
tRNA modification in the nucleus and cytosol 28 0.459000 8.10e-02 0.8640
Ub-specific processing proteases 130 0.461000 3.76e-02 0.8640
Leishmania infection 107 0.462000 -4.13e-02 0.8640
Deactivation of the beta-catenin transactivating complex 27 0.463000 -8.17e-02 0.8640
Deposition of new CENPA-containing nucleosomes at the centromere 20 0.463000 -9.48e-02 0.8640
Nucleosome assembly 20 0.463000 -9.48e-02 0.8640
NIK–>noncanonical NF-kB signaling 49 0.464000 6.06e-02 0.8640
ERK/MAPK targets 16 0.464000 1.06e-01 0.8640
Signaling by Non-Receptor Tyrosine Kinases 33 0.465000 7.35e-02 0.8640
Signaling by PTK6 33 0.465000 7.35e-02 0.8640
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 0.466000 -1.13e-01 0.8640
Asymmetric localization of PCP proteins 51 0.469000 5.87e-02 0.8670
Gap-filling DNA repair synthesis and ligation in GG-NER 23 0.472000 8.67e-02 0.8670
Metabolism of lipids 411 0.473000 -2.09e-02 0.8670
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 0.473000 6.48e-02 0.8670
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 0.473000 6.48e-02 0.8670
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 0.473000 6.48e-02 0.8670
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 0.473000 6.48e-02 0.8670
Signaling by NOTCH1 in Cancer 41 0.473000 6.48e-02 0.8670
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 20 0.477000 9.20e-02 0.8720
RHOA GTPase cycle 86 0.478000 4.44e-02 0.8720
Clathrin-mediated endocytosis 89 0.480000 -4.35e-02 0.8730
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 0.480000 1.18e-01 0.8730
VEGFA-VEGFR2 Pathway 69 0.481000 4.92e-02 0.8730
Mitochondrial calcium ion transport 13 0.482000 1.13e-01 0.8740
InlB-mediated entry of Listeria monocytogenes into host cell 11 0.483000 -1.22e-01 0.8750
Josephin domain DUBs 11 0.485000 -1.22e-01 0.8760
Glycogen metabolism 17 0.485000 -9.79e-02 0.8760
Interleukin-6 signaling 10 0.488000 1.27e-01 0.8770
Glycerophospholipid biosynthesis 69 0.489000 4.83e-02 0.8770
SCF(Skp2)-mediated degradation of p27/p21 51 0.489000 5.61e-02 0.8770
ERKs are inactivated 11 0.489000 1.20e-01 0.8770
Visual phototransduction 32 0.490000 -7.06e-02 0.8770
ADP signalling through P2Y purinoceptor 12 10 0.493000 1.25e-01 0.8820
PINK1-PRKN Mediated Mitophagy 20 0.497000 8.79e-02 0.8860
Toll-like Receptor Cascades 97 0.497000 4.00e-02 0.8860
Cargo recognition for clathrin-mediated endocytosis 64 0.498000 -4.91e-02 0.8860
RIP-mediated NFkB activation via ZBP1 12 0.499000 1.13e-01 0.8860
RHOG GTPase cycle 45 0.499000 -5.83e-02 0.8860
Signaling by NOTCH2 18 0.502000 -9.15e-02 0.8870
Regulated Necrosis 41 0.503000 6.06e-02 0.8870
Toll Like Receptor 9 (TLR9) Cascade 64 0.503000 4.85e-02 0.8870
Axon guidance 283 0.504000 2.33e-02 0.8870
HDR through Homologous Recombination (HRR) 54 0.504000 5.27e-02 0.8870
BMAL1:CLOCK,NPAS2 activates circadian gene expression 14 0.505000 1.03e-01 0.8880
MAP kinase activation 46 0.509000 5.63e-02 0.8890
RHOBTB2 GTPase cycle 19 0.509000 8.75e-02 0.8890
Homologous DNA Pairing and Strand Exchange 34 0.509000 6.55e-02 0.8890
Plasma lipoprotein clearance 19 0.510000 -8.75e-02 0.8890
TRAF3-dependent IRF activation pathway 13 0.511000 -1.05e-01 0.8890
MyD88 dependent cascade initiated on endosome 62 0.511000 4.84e-02 0.8890
Toll Like Receptor 7/8 (TLR7/8) Cascade 62 0.511000 4.84e-02 0.8890
trans-Golgi Network Vesicle Budding 50 0.512000 -5.37e-02 0.8890
Toll Like Receptor 3 (TLR3) Cascade 70 0.515000 4.51e-02 0.8910
Metabolism of steroids 80 0.515000 -4.22e-02 0.8910
Translation of Replicase and Assembly of the Replication Transcription Complex 10 0.516000 1.19e-01 0.8910
Signaling by Hedgehog 97 0.516000 -3.83e-02 0.8910
G alpha (12/13) signalling events 33 0.517000 6.53e-02 0.8910
G-protein beta:gamma signalling 18 0.518000 8.80e-02 0.8910
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 0.519000 -1.18e-01 0.8910
Aberrant regulation of mitotic cell cycle due to RB1 defects 29 0.519000 -6.92e-02 0.8910
Fatty acyl-CoA biosynthesis 22 0.520000 7.92e-02 0.8920
Signaling by KIT in disease 16 0.523000 -9.23e-02 0.8930
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 0.523000 -9.23e-02 0.8930
Kinesins 30 0.529000 6.65e-02 0.9020
CDT1 association with the CDC6:ORC:origin complex 44 0.530000 5.48e-02 0.9020
PCP/CE pathway 70 0.530000 4.35e-02 0.9020
SLC transporter disorders 46 0.531000 5.35e-02 0.9020
Signaling by FGFR in disease 37 0.532000 -5.94e-02 0.9020
Fcgamma receptor (FCGR) dependent phagocytosis 61 0.536000 4.59e-02 0.9040
Pre-NOTCH Transcription and Translation 26 0.536000 -7.02e-02 0.9040
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 14 0.538000 9.52e-02 0.9040
RHOD GTPase cycle 33 0.538000 6.21e-02 0.9040
RAC1 GTPase cycle 102 0.539000 3.53e-02 0.9040
Cell surface interactions at the vascular wall 56 0.539000 4.75e-02 0.9040
B-WICH complex positively regulates rRNA expression 25 0.541000 7.08e-02 0.9040
CTLA4 inhibitory signaling 15 0.542000 9.11e-02 0.9040
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 0.543000 -7.03e-02 0.9040
Class B/2 (Secretin family receptors) 25 0.543000 -7.03e-02 0.9040
Diseases associated with glycosaminoglycan metabolism 15 0.544000 -9.06e-02 0.9040
IRS-related events triggered by IGF1R 21 0.544000 -7.65e-02 0.9040
Meiotic synapsis 22 0.545000 7.46e-02 0.9040
Metabolic disorders of biological oxidation enzymes 14 0.546000 -9.33e-02 0.9040
ABC-family proteins mediated transport 71 0.547000 4.14e-02 0.9040
Sema4D induced cell migration and growth-cone collapse 11 0.547000 1.05e-01 0.9040
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 32 0.548000 -6.14e-02 0.9040
Signal transduction by L1 11 0.551000 -1.04e-01 0.9040
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 0.551000 -8.89e-02 0.9040
G-protein activation 10 0.552000 1.09e-01 0.9040
Metal ion SLC transporters 13 0.552000 -9.53e-02 0.9040
Thrombin signalling through proteinase activated receptors (PARs) 17 0.552000 -8.33e-02 0.9040
Glucagon-type ligand receptors 11 0.554000 1.03e-01 0.9040
Switching of origins to a post-replicative state 70 0.554000 4.09e-02 0.9040
GAB1 signalosome 10 0.554000 1.08e-01 0.9040
TGF-beta receptor signaling activates SMADs 30 0.555000 -6.24e-02 0.9040
Prolonged ERK activation events 13 0.555000 -9.47e-02 0.9040
Signaling by Nuclear Receptors 142 0.556000 2.87e-02 0.9040
Signaling by ERBB2 KD Mutants 10 0.557000 -1.07e-01 0.9040
Aggrephagy 19 0.557000 -7.79e-02 0.9040
Developmental Biology 438 0.558000 1.65e-02 0.9040
Zinc transporters 10 0.558000 -1.07e-01 0.9040
APC/C-mediated degradation of cell cycle proteins 73 0.560000 3.95e-02 0.9040
Regulation of mitotic cell cycle 73 0.560000 3.95e-02 0.9040
Gap junction trafficking and regulation 10 0.561000 1.06e-01 0.9040
TRAF6 mediated NF-kB activation 17 0.564000 8.08e-02 0.9040
Smooth Muscle Contraction 19 0.565000 7.62e-02 0.9040
Hh mutants are degraded by ERAD 46 0.566000 4.90e-02 0.9040
Signaling by FGFR2 46 0.566000 -4.89e-02 0.9040
Dectin-1 mediated noncanonical NF-kB signaling 50 0.566000 4.69e-02 0.9040
Striated Muscle Contraction 10 0.568000 -1.04e-01 0.9040
Synthesis of very long-chain fatty acyl-CoAs 12 0.568000 9.53e-02 0.9040
Constitutive Signaling by Aberrant PI3K in Cancer 26 0.569000 6.46e-02 0.9040
RNA Polymerase III Transcription Termination 20 0.569000 7.36e-02 0.9040
Extra-nuclear estrogen signaling 46 0.570000 4.85e-02 0.9040
Death Receptor Signalling 88 0.571000 -3.50e-02 0.9040
Nucleobase biosynthesis 12 0.572000 9.42e-02 0.9040
Regulation of HMOX1 expression and activity 54 0.572000 4.45e-02 0.9040
Regulation of beta-cell development 15 0.572000 8.43e-02 0.9040
RUNX1 regulates transcription of genes involved in differentiation of HSCs 55 0.575000 4.38e-02 0.9040
Degradation of the extracellular matrix 26 0.576000 6.33e-02 0.9040
TNFR1-induced NFkappaB signaling pathway 19 0.577000 7.40e-02 0.9040
MyD88-independent TLR4 cascade 70 0.577000 3.86e-02 0.9040
TRIF(TICAM1)-mediated TLR4 signaling 70 0.577000 3.86e-02 0.9040
rRNA modification in the nucleus and cytosol 42 0.577000 4.98e-02 0.9040
DNA Damage Recognition in GG-NER 35 0.579000 -5.42e-02 0.9060
Regulation of MECP2 expression and activity 20 0.581000 7.13e-02 0.9060
Signaling by PDGF 24 0.585000 -6.45e-02 0.9060
Uptake and actions of bacterial toxins 18 0.585000 -7.44e-02 0.9060
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 0.586000 4.81e-02 0.9060
p53-Independent DNA Damage Response 43 0.586000 4.81e-02 0.9060
p53-Independent G1/S DNA damage checkpoint 43 0.586000 4.81e-02 0.9060
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 34 0.586000 -5.40e-02 0.9060
Metalloprotease DUBs 16 0.587000 -7.85e-02 0.9060
Homology Directed Repair 84 0.587000 3.44e-02 0.9060
Phosphorylation of the APC/C 15 0.587000 -8.10e-02 0.9060
Factors involved in megakaryocyte development and platelet production 83 0.588000 3.45e-02 0.9060
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 15 0.588000 -8.07e-02 0.9060
Negative regulation of MAPK pathway 35 0.591000 -5.26e-02 0.9090
Defective CFTR causes cystic fibrosis 51 0.594000 4.33e-02 0.9110
IRS-mediated signalling 20 0.597000 -6.83e-02 0.9140
Transport of vitamins, nucleosides, and related molecules 21 0.600000 -6.62e-02 0.9140
G alpha (z) signalling events 22 0.600000 6.46e-02 0.9140
FGFR1 mutant receptor activation 19 0.601000 -6.94e-02 0.9140
Signaling by Receptor Tyrosine Kinases 273 0.601000 1.85e-02 0.9140
Metabolism of amino acids and derivatives 210 0.602000 2.10e-02 0.9140
O-linked glycosylation of mucins 26 0.603000 -5.90e-02 0.9140
Diseases of mitotic cell cycle 30 0.604000 -5.48e-02 0.9140
Regulation of lipid metabolism by PPARalpha 83 0.604000 3.30e-02 0.9140
Post-translational modification: synthesis of GPI-anchored proteins 30 0.606000 -5.45e-02 0.9140
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 21 0.608000 -6.47e-02 0.9140
Sensory processing of sound 24 0.609000 -6.03e-02 0.9140
Sensory processing of sound by inner hair cells of the cochlea 24 0.609000 -6.03e-02 0.9140
mTORC1-mediated signalling 17 0.613000 7.10e-02 0.9140
MAP2K and MAPK activation 22 0.613000 6.23e-02 0.9140
Signaling by high-kinase activity BRAF mutants 22 0.613000 6.23e-02 0.9140
Mitochondrial translation 86 0.614000 3.15e-02 0.9140
Effects of PIP2 hydrolysis 18 0.614000 6.86e-02 0.9140
NRAGE signals death through JNK 25 0.618000 -5.77e-02 0.9140
Endosomal Sorting Complex Required For Transport (ESCRT) 24 0.619000 5.87e-02 0.9140
PIWI-interacting RNA (piRNA) biogenesis 14 0.620000 7.66e-02 0.9140
BBSome-mediated cargo-targeting to cilium 18 0.621000 -6.73e-02 0.9140
Signaling by NOTCH3 30 0.621000 5.21e-02 0.9140
Cytochrome c-mediated apoptotic response 10 0.623000 -8.98e-02 0.9140
Ca2+ pathway 34 0.624000 4.87e-02 0.9140
Sialic acid metabolism 22 0.625000 6.02e-02 0.9140
MyD88 cascade initiated on plasma membrane 60 0.629000 3.61e-02 0.9140
Toll Like Receptor 10 (TLR10) Cascade 60 0.629000 3.61e-02 0.9140
Toll Like Receptor 5 (TLR5) Cascade 60 0.629000 3.61e-02 0.9140
CDK-mediated phosphorylation and removal of Cdc6 58 0.629000 3.67e-02 0.9140
Other interleukin signaling 16 0.630000 -6.96e-02 0.9140
FCERI mediated MAPK activation 22 0.630000 5.93e-02 0.9140
Diseases associated with the TLR signaling cascade 16 0.631000 6.94e-02 0.9140
Diseases of Immune System 16 0.631000 6.94e-02 0.9140
HIV Life Cycle 117 0.632000 2.57e-02 0.9140
Infection with Mycobacterium tuberculosis 22 0.633000 -5.89e-02 0.9140
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 0.633000 5.13e-02 0.9140
Signaling by RAS mutants 29 0.633000 5.13e-02 0.9140
Signaling by moderate kinase activity BRAF mutants 29 0.633000 5.13e-02 0.9140
Signaling downstream of RAS mutants 29 0.633000 5.13e-02 0.9140
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 0.633000 8.31e-02 0.9140
Mitochondrial biogenesis 50 0.635000 3.89e-02 0.9140
HIV Transcription Initiation 37 0.635000 4.51e-02 0.9140
RNA Polymerase II HIV Promoter Escape 37 0.635000 4.51e-02 0.9140
RNA Polymerase II Promoter Escape 37 0.635000 4.51e-02 0.9140
RNA Polymerase II Transcription Initiation 37 0.635000 4.51e-02 0.9140
RNA Polymerase II Transcription Initiation And Promoter Clearance 37 0.635000 4.51e-02 0.9140
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 37 0.635000 4.51e-02 0.9140
Metabolism of porphyrins 15 0.635000 -7.08e-02 0.9140
Sema4D in semaphorin signaling 13 0.637000 7.57e-02 0.9140
Platelet sensitization by LDL 13 0.637000 7.57e-02 0.9140
Synthesis of IP3 and IP4 in the cytosol 16 0.637000 -6.81e-02 0.9140
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 60 0.638000 3.52e-02 0.9140
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 15 0.638000 7.01e-02 0.9140
Degradation of GLI1 by the proteasome 50 0.639000 3.84e-02 0.9140
Peptide hormone metabolism 23 0.641000 5.62e-02 0.9140
G0 and Early G1 24 0.641000 5.50e-02 0.9140
Signaling by RAF1 mutants 25 0.642000 5.38e-02 0.9140
RHOJ GTPase cycle 34 0.646000 -4.56e-02 0.9190
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 0.647000 -7.33e-02 0.9190
DNA Double-Strand Break Repair 106 0.647000 2.58e-02 0.9190
RHO GTPases activate PAKs 13 0.649000 7.30e-02 0.9190
Transcription of the HIV genome 50 0.649000 3.72e-02 0.9190
Fanconi Anemia Pathway 29 0.651000 -4.86e-02 0.9200
APC/C:Cdc20 mediated degradation of mitotic proteins 61 0.652000 3.35e-02 0.9200
PPARA activates gene expression 81 0.653000 2.90e-02 0.9200
COPII-mediated vesicle transport 47 0.654000 -3.79e-02 0.9200
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 0.654000 7.47e-02 0.9200
Antigen processing: Ubiquitination & Proteasome degradation 226 0.657000 1.72e-02 0.9200
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 48 0.659000 3.68e-02 0.9200
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 78 0.661000 2.88e-02 0.9200
Signaling by PDGFR in disease 15 0.661000 6.55e-02 0.9200
Heme signaling 25 0.661000 -5.08e-02 0.9200
Early Phase of HIV Life Cycle 13 0.662000 -7.00e-02 0.9200
SUMOylation of transcription factors 13 0.662000 -7.00e-02 0.9200
ABC transporter disorders 56 0.663000 3.37e-02 0.9200
DNA Double Strand Break Response 33 0.663000 -4.38e-02 0.9200
DARPP-32 events 18 0.663000 -5.93e-02 0.9200
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 0.664000 5.61e-02 0.9200
Signaling by FGFR 50 0.666000 -3.53e-02 0.9200
Late endosomal microautophagy 21 0.667000 -5.43e-02 0.9200
G beta:gamma signalling through PLC beta 10 0.669000 7.80e-02 0.9200
Presynaptic function of Kainate receptors 10 0.669000 7.80e-02 0.9200
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 0.670000 6.82e-02 0.9200
RAF activation 27 0.671000 4.73e-02 0.9200
TCF dependent signaling in response to WNT 117 0.671000 2.28e-02 0.9200
Signalling to ERKs 25 0.672000 -4.90e-02 0.9200
Transport of bile salts and organic acids, metal ions and amine compounds 29 0.672000 -4.55e-02 0.9200
G alpha (q) signalling events 70 0.672000 -2.93e-02 0.9200
Gluconeogenesis 24 0.673000 -4.99e-02 0.9200
Interleukin-1 signaling 74 0.673000 2.85e-02 0.9200
Negative regulators of DDX58/IFIH1 signaling 33 0.675000 4.22e-02 0.9210
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 37 0.676000 3.97e-02 0.9210
Signaling by NTRK3 (TRKC) 10 0.676000 -7.63e-02 0.9210
mRNA Capping 25 0.676000 4.82e-02 0.9210
RND3 GTPase cycle 28 0.678000 4.54e-02 0.9220
ZBP1(DAI) mediated induction of type I IFNs 15 0.682000 6.12e-02 0.9260
Asparagine N-linked glycosylation 214 0.684000 1.63e-02 0.9260
RHO GTPases Activate ROCKs 13 0.685000 6.50e-02 0.9260
Hh mutants abrogate ligand secretion 48 0.686000 3.37e-02 0.9260
Notch-HLH transcription pathway 21 0.687000 5.09e-02 0.9260
Synthesis of PIPs at the plasma membrane 36 0.687000 -3.89e-02 0.9260
RAC3 GTPase cycle 55 0.687000 3.15e-02 0.9260
Protein ubiquitination 55 0.687000 3.14e-02 0.9260
p75 NTR receptor-mediated signalling 54 0.688000 -3.16e-02 0.9260
Defects in vitamin and cofactor metabolism 16 0.689000 5.78e-02 0.9260
Glycolysis 54 0.692000 3.12e-02 0.9300
Degradation of AXIN 46 0.698000 3.31e-02 0.9350
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 32 0.700000 3.94e-02 0.9350
G1/S-Specific Transcription 24 0.700000 -4.54e-02 0.9350
Hedgehog ligand biogenesis 51 0.702000 3.10e-02 0.9350
Semaphorin interactions 36 0.703000 -3.68e-02 0.9350
Toll Like Receptor 4 (TLR4) Cascade 87 0.705000 2.36e-02 0.9350
PI Metabolism 59 0.705000 -2.85e-02 0.9350
FGFR2 mutant receptor activation 15 0.707000 5.62e-02 0.9350
E3 ubiquitin ligases ubiquitinate target proteins 39 0.708000 3.47e-02 0.9350
GABA receptor activation 16 0.709000 -5.40e-02 0.9350
Signal amplification 17 0.709000 5.23e-02 0.9350
Signaling by FGFR2 IIIa TM 14 0.709000 5.75e-02 0.9350
RMTs methylate histone arginines 23 0.711000 4.47e-02 0.9350
Platelet calcium homeostasis 17 0.712000 -5.18e-02 0.9350
Disorders of Developmental Biology 10 0.712000 -6.75e-02 0.9350
Disorders of Nervous System Development 10 0.712000 -6.75e-02 0.9350
Loss of function of MECP2 in Rett syndrome 10 0.712000 -6.75e-02 0.9350
Pervasive developmental disorders 10 0.712000 -6.75e-02 0.9350
Phase I - Functionalization of compounds 29 0.712000 3.96e-02 0.9350
Deadenylation of mRNA 22 0.714000 4.51e-02 0.9360
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 68 0.715000 2.56e-02 0.9360
Regulation of Apoptosis 44 0.716000 3.17e-02 0.9360
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 62 0.718000 2.66e-02 0.9360
ISG15 antiviral mechanism 67 0.718000 2.55e-02 0.9360
Metabolism of steroid hormones 13 0.719000 5.77e-02 0.9360
Peroxisomal lipid metabolism 20 0.720000 4.64e-02 0.9360
Autodegradation of Cdh1 by Cdh1:APC/C 52 0.720000 2.88e-02 0.9360
Hedgehog ‘on’ state 61 0.727000 2.59e-02 0.9430
Response of EIF2AK1 (HRI) to heme deficiency 13 0.728000 -5.58e-02 0.9430
RAC2 GTPase cycle 52 0.730000 -2.78e-02 0.9430
Transcriptional activation of mitochondrial biogenesis 36 0.731000 3.32e-02 0.9430
Opioid Signalling 52 0.731000 -2.76e-02 0.9430
Dual Incision in GG-NER 35 0.731000 -3.36e-02 0.9430
Resolution of D-loop Structures through Holliday Junction Intermediates 23 0.732000 4.14e-02 0.9430
Regulation of TP53 Expression and Degradation 34 0.732000 3.39e-02 0.9430
RNA Polymerase III Transcription Initiation From Type 3 Promoter 25 0.732000 3.95e-02 0.9430
activated TAK1 mediates p38 MAPK activation 12 0.736000 5.62e-02 0.9460
Base Excision Repair 38 0.736000 3.16e-02 0.9460
Intra-Golgi traffic 38 0.737000 3.15e-02 0.9460
SUMOylation of chromatin organization proteins 47 0.740000 2.80e-02 0.9460
Inositol phosphate metabolism 29 0.740000 -3.56e-02 0.9460
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 59 0.740000 2.50e-02 0.9460
Signaling by FGFR2 in disease 22 0.740000 -4.08e-02 0.9460
Energy dependent regulation of mTOR by LKB1-AMPK 21 0.741000 4.16e-02 0.9460
Circadian Clock 50 0.744000 -2.68e-02 0.9470
Cyclin D associated events in G1 40 0.744000 2.98e-02 0.9470
G1 Phase 40 0.744000 2.98e-02 0.9470
Downregulation of TGF-beta receptor signaling 25 0.746000 -3.74e-02 0.9480
ER to Golgi Anterograde Transport 101 0.747000 1.86e-02 0.9480
Class I MHC mediated antigen processing & presentation 267 0.749000 1.15e-02 0.9480
Translesion synthesis by REV1 14 0.750000 4.93e-02 0.9480
Pexophagy 11 0.752000 -5.50e-02 0.9480
Ion transport by P-type ATPases 26 0.752000 -3.58e-02 0.9480
Transcriptional regulation by RUNX2 82 0.753000 2.01e-02 0.9480
Regulation of APC/C activators between G1/S and early anaphase 66 0.754000 2.23e-02 0.9480
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 0.755000 5.71e-02 0.9480
Mitochondrial translation elongation 81 0.756000 2.00e-02 0.9480
Base-Excision Repair, AP Site Formation 15 0.757000 -4.62e-02 0.9480
Signaling by FLT3 fusion proteins 16 0.757000 -4.47e-02 0.9480
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 18 0.759000 4.18e-02 0.9480
Regulation of TP53 Degradation 33 0.760000 3.08e-02 0.9480
RNA Pol II CTD phosphorylation and interaction with CE 23 0.761000 3.67e-02 0.9480
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 23 0.761000 3.67e-02 0.9480
Response of Mtb to phagocytosis 20 0.761000 -3.92e-02 0.9480
Global Genome Nucleotide Excision Repair (GG-NER) 76 0.762000 -2.01e-02 0.9480
CDC42 GTPase cycle 91 0.763000 -1.84e-02 0.9480
Activation of GABAB receptors 15 0.763000 -4.51e-02 0.9480
GABA B receptor activation 15 0.763000 -4.51e-02 0.9480
p75NTR signals via NF-kB 11 0.764000 -5.23e-02 0.9490
Mitochondrial translation initiation 81 0.765000 1.92e-02 0.9490
Metabolism of folate and pterines 11 0.766000 5.19e-02 0.9490
Selective autophagy 50 0.771000 2.39e-02 0.9530
Cytosolic sensors of pathogen-associated DNA 48 0.771000 -2.43e-02 0.9530
RAF-independent MAPK1/3 activation 19 0.772000 -3.83e-02 0.9530
Recognition of DNA damage by PCNA-containing replication complex 25 0.773000 3.33e-02 0.9530
Detoxification of Reactive Oxygen Species 22 0.774000 -3.55e-02 0.9530
UCH proteinases 69 0.774000 2.00e-02 0.9530
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 20 0.776000 -3.68e-02 0.9530
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 58 0.778000 2.14e-02 0.9530
Budding and maturation of HIV virion 21 0.780000 3.53e-02 0.9530
Neutrophil degranulation 288 0.780000 9.62e-03 0.9530
Signaling by cytosolic FGFR1 fusion mutants 16 0.781000 -4.02e-02 0.9530
Formation of HIV elongation complex in the absence of HIV Tat 31 0.781000 2.88e-02 0.9530
Formation of HIV-1 elongation complex containing HIV-1 Tat 31 0.781000 2.88e-02 0.9530
HIV Transcription Elongation 31 0.781000 2.88e-02 0.9530
Tat-mediated elongation of the HIV-1 transcript 31 0.781000 2.88e-02 0.9530
Interleukin-17 signaling 49 0.783000 2.28e-02 0.9540
Regulation of TP53 Activity through Methylation 16 0.786000 -3.93e-02 0.9560
Purine ribonucleoside monophosphate biosynthesis 10 0.788000 4.92e-02 0.9570
IGF1R signaling cascade 22 0.792000 -3.25e-02 0.9570
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 22 0.792000 -3.25e-02 0.9570
APC truncation mutants have impaired AXIN binding 12 0.796000 4.32e-02 0.9570
AXIN missense mutants destabilize the destruction complex 12 0.796000 4.32e-02 0.9570
Signaling by AMER1 mutants 12 0.796000 4.32e-02 0.9570
Signaling by APC mutants 12 0.796000 4.32e-02 0.9570
Signaling by AXIN mutants 12 0.796000 4.32e-02 0.9570
Truncations of AMER1 destabilize the destruction complex 12 0.796000 4.32e-02 0.9570
Glucose metabolism 69 0.797000 1.80e-02 0.9570
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 0.797000 4.29e-02 0.9570
Trafficking of AMPA receptors 12 0.797000 4.29e-02 0.9570
Synthesis of glycosylphosphatidylinositol (GPI) 14 0.799000 3.93e-02 0.9590
RORA activates gene expression 10 0.800000 -4.62e-02 0.9590
Post-translational protein phosphorylation 33 0.801000 -2.54e-02 0.9590
Metabolism 1168 0.804000 -4.46e-03 0.9590
TNFR1-induced proapoptotic signaling 12 0.807000 4.09e-02 0.9590
Cleavage of the damaged purine 10 0.808000 4.45e-02 0.9590
Depurination 10 0.808000 4.45e-02 0.9590
Recognition and association of DNA glycosylase with site containing an affected purine 10 0.808000 4.45e-02 0.9590
The role of Nef in HIV-1 replication and disease pathogenesis 19 0.809000 -3.20e-02 0.9590
Metabolism of nucleotides 68 0.809000 1.69e-02 0.9590
Transcription of E2F targets under negative control by DREAM complex 17 0.812000 -3.34e-02 0.9590
Processing of DNA double-strand break ends 52 0.813000 1.90e-02 0.9590
N-glycan antennae elongation in the medial/trans-Golgi 18 0.816000 -3.17e-02 0.9590
Regulation of IFNG signaling 13 0.817000 3.72e-02 0.9590
Signaling by EGFR in Cancer 15 0.817000 -3.45e-02 0.9590
Oncogene Induced Senescence 27 0.818000 -2.57e-02 0.9590
APC/C:Cdc20 mediated degradation of Securin 54 0.819000 1.81e-02 0.9590
Heme biosynthesis 10 0.820000 4.16e-02 0.9590
EGFR downregulation 20 0.820000 -2.94e-02 0.9590
Non-integrin membrane-ECM interactions 12 0.821000 -3.78e-02 0.9590
Cleavage of the damaged pyrimidine 13 0.822000 3.61e-02 0.9590
Depyrimidination 13 0.822000 3.61e-02 0.9590
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 13 0.822000 3.61e-02 0.9590
Synthesis of substrates in N-glycan biosythesis 43 0.822000 1.99e-02 0.9590
Translesion synthesis by POLI 15 0.822000 3.35e-02 0.9590
Muscle contraction 64 0.823000 1.62e-02 0.9590
Transport to the Golgi and subsequent modification 124 0.823000 1.16e-02 0.9590
Mitochondrial translation termination 80 0.825000 1.43e-02 0.9590
Autophagy 95 0.825000 -1.31e-02 0.9590
Generic Transcription Pathway 771 0.826000 -4.76e-03 0.9590
Interleukin-35 Signalling 11 0.826000 -3.83e-02 0.9590
Interleukin-20 family signaling 13 0.827000 3.50e-02 0.9590
Regulation of insulin secretion 36 0.828000 2.09e-02 0.9590
MET promotes cell motility 12 0.829000 3.60e-02 0.9590
Oncogenic MAPK signaling 54 0.829000 -1.70e-02 0.9590
Interleukin-1 family signaling 92 0.830000 1.30e-02 0.9590
Post-chaperonin tubulin folding pathway 12 0.831000 3.56e-02 0.9590
Unwinding of DNA 10 0.832000 3.87e-02 0.9590
RIPK1-mediated regulated necrosis 24 0.832000 2.50e-02 0.9590
Regulation of necroptotic cell death 24 0.832000 2.50e-02 0.9590
DNA Repair 232 0.835000 -7.99e-03 0.9610
Phospholipid metabolism 127 0.837000 1.06e-02 0.9620
Synthesis of PIPs at the early endosome membrane 11 0.839000 3.53e-02 0.9640
Regulation of RUNX1 Expression and Activity 12 0.841000 3.36e-02 0.9640
Frs2-mediated activation 11 0.841000 3.50e-02 0.9640
SUMOylation of intracellular receptors 19 0.843000 2.62e-02 0.9640
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 13 0.844000 -3.16e-02 0.9640
Signaling by Ligand-Responsive EGFR Variants in Cancer 13 0.844000 -3.16e-02 0.9640
TP53 Regulates Transcription of DNA Repair Genes 45 0.844000 1.69e-02 0.9640
Cytoprotection by HMOX1 90 0.845000 1.20e-02 0.9640
SUMOylation of transcription cofactors 35 0.845000 1.91e-02 0.9640
Molecules associated with elastic fibres 10 0.849000 3.49e-02 0.9650
IKK complex recruitment mediated by RIP1 17 0.849000 -2.67e-02 0.9650
HSF1 activation 21 0.849000 2.40e-02 0.9650
SHC1 events in ERBB2 signaling 10 0.852000 3.41e-02 0.9670
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 19 0.854000 2.43e-02 0.9680
Mitophagy 25 0.854000 -2.12e-02 0.9680
Interconversion of nucleotide di- and triphosphates 21 0.858000 -2.25e-02 0.9710
Downstream signal transduction 20 0.858000 -2.31e-02 0.9710
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 34 0.861000 1.73e-02 0.9730
Formation of TC-NER Pre-Incision Complex 45 0.863000 -1.49e-02 0.9730
Hedgehog ‘off’ state 74 0.863000 1.16e-02 0.9730
MHC class II antigen presentation 64 0.866000 -1.22e-02 0.9740
Inactivation, recovery and regulation of the phototransduction cascade 16 0.867000 2.43e-02 0.9740
The phototransduction cascade 16 0.867000 2.43e-02 0.9740
TP53 Regulates Metabolic Genes 60 0.871000 -1.21e-02 0.9790
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 22 0.873000 1.98e-02 0.9790
Interleukin-15 signaling 11 0.874000 2.76e-02 0.9790
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 16 0.875000 -2.28e-02 0.9790
SUMOylation of DNA methylation proteins 14 0.877000 -2.40e-02 0.9800
FLT3 signaling in disease 24 0.878000 -1.81e-02 0.9800
Signaling by NOTCH1 51 0.879000 1.24e-02 0.9800
Purine salvage 11 0.879000 2.65e-02 0.9800
PRC2 methylates histones and DNA 11 0.880000 -2.63e-02 0.9800
Synthesis of PIPs at the Golgi membrane 11 0.880000 2.62e-02 0.9800
Suppression of phagosomal maturation 12 0.881000 -2.50e-02 0.9800
Gamma carboxylation, hypusine formation and arylsulfatase activation 21 0.884000 1.84e-02 0.9800
Signaling by TGF-beta Receptor Complex 59 0.885000 -1.09e-02 0.9800
Diseases of programmed cell death 36 0.886000 1.39e-02 0.9800
Integration of energy metabolism 56 0.886000 -1.11e-02 0.9800
Translesion Synthesis by POLH 16 0.886000 -2.07e-02 0.9800
Abortive elongation of HIV-1 transcript in the absence of Tat 17 0.888000 -1.98e-02 0.9800
Sensory processing of sound by outer hair cells of the cochlea 15 0.888000 2.10e-02 0.9800
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 10 0.889000 2.56e-02 0.9800
Pre-NOTCH Expression and Processing 40 0.892000 -1.25e-02 0.9800
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 0.892000 1.35e-02 0.9800
Collagen biosynthesis and modifying enzymes 13 0.893000 -2.17e-02 0.9800
EPH-Ephrin signaling 54 0.893000 1.06e-02 0.9800
Signaling by ERBB2 31 0.893000 -1.39e-02 0.9800
CD28 co-stimulation 27 0.893000 1.49e-02 0.9800
Cytochrome P450 - arranged by substrate type 14 0.895000 2.04e-02 0.9800
ADP signalling through P2Y purinoceptor 1 13 0.895000 -2.12e-02 0.9800
Signaling by NTRK2 (TRKB) 15 0.898000 -1.91e-02 0.9820
Elevation of cytosolic Ca2+ levels 10 0.899000 2.31e-02 0.9830
Transcriptional Regulation by E2F6 28 0.901000 -1.37e-02 0.9830
TRAF6 mediated IRF7 activation 15 0.901000 -1.86e-02 0.9830
Termination of O-glycan biosynthesis 10 0.902000 2.25e-02 0.9830
Signaling by TGFB family members 71 0.905000 8.21e-03 0.9830
HIV elongation arrest and recovery 21 0.906000 1.48e-02 0.9830
Pausing and recovery of HIV elongation 21 0.906000 1.48e-02 0.9830
Pausing and recovery of Tat-mediated HIV elongation 21 0.906000 1.48e-02 0.9830
Tat-mediated HIV elongation arrest and recovery 21 0.906000 1.48e-02 0.9830
RHO GTPases Activate NADPH Oxidases 14 0.909000 -1.76e-02 0.9840
Ion homeostasis 25 0.912000 -1.28e-02 0.9840
Activation of kainate receptors upon glutamate binding 14 0.913000 -1.70e-02 0.9840
RHOBTB GTPase Cycle 28 0.916000 1.15e-02 0.9840
Signaling by ERBB2 in Cancer 11 0.917000 -1.82e-02 0.9840
VEGFR2 mediated cell proliferation 16 0.918000 1.49e-02 0.9840
Metabolism of nitric oxide: NOS3 activation and regulation 12 0.918000 1.71e-02 0.9840
Retrograde transport at the Trans-Golgi-Network 42 0.918000 -9.15e-03 0.9840
SUMOylation of immune response proteins 10 0.920000 1.83e-02 0.9840
Activation of BH3-only proteins 25 0.920000 1.16e-02 0.9840
Sulfur amino acid metabolism 15 0.921000 1.47e-02 0.9840
Negative regulation of MET activity 16 0.922000 -1.42e-02 0.9840
EPHB-mediated forward signaling 25 0.923000 -1.12e-02 0.9840
Resolution of D-Loop Structures 24 0.924000 1.12e-02 0.9840
Prefoldin mediated transfer of substrate to CCT/TriC 16 0.925000 -1.37e-02 0.9840
TNF signaling 35 0.926000 -9.09e-03 0.9840
Signaling by MET 39 0.926000 -8.57e-03 0.9840
Downstream signaling of activated FGFR1 11 0.927000 1.59e-02 0.9840
Downstream signaling of activated FGFR2 11 0.927000 1.59e-02 0.9840
Downstream signaling of activated FGFR3 11 0.927000 1.59e-02 0.9840
Downstream signaling of activated FGFR4 11 0.927000 1.59e-02 0.9840
Signaling by SCF-KIT 32 0.929000 -9.09e-03 0.9840
Transcriptional regulation of white adipocyte differentiation 55 0.929000 -6.94e-03 0.9840
DNA Damage Bypass 40 0.930000 8.00e-03 0.9840
RAB geranylgeranylation 39 0.931000 -8.07e-03 0.9840
Interleukin-6 family signaling 13 0.931000 1.39e-02 0.9840
Interleukin-7 signaling 14 0.932000 1.32e-02 0.9840
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 15 0.932000 -1.27e-02 0.9840
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 15 0.932000 -1.27e-02 0.9840
Signaling by CSF3 (G-CSF) 25 0.933000 9.69e-03 0.9840
Macroautophagy 87 0.935000 -5.09e-03 0.9840
Interleukin-37 signaling 16 0.935000 -1.18e-02 0.9840
Inwardly rectifying K+ channels 10 0.937000 1.44e-02 0.9860
EPH-ephrin mediated repulsion of cells 24 0.938000 -9.15e-03 0.9860
Membrane Trafficking 419 0.939000 2.21e-03 0.9860
Vesicle-mediated transport 426 0.940000 2.14e-03 0.9860
FGFR2 alternative splicing 21 0.942000 -9.22e-03 0.9860
Sensory Perception 63 0.942000 -5.31e-03 0.9860
Nonhomologous End-Joining (NHEJ) 27 0.947000 7.44e-03 0.9890
Inactivation of CSF3 (G-CSF) signaling 20 0.948000 8.46e-03 0.9890
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 0.948000 -7.82e-03 0.9890
Extracellular matrix organization 75 0.949000 4.31e-03 0.9890
Translocation of SLC2A4 (GLUT4) to the plasma membrane 43 0.949000 -5.64e-03 0.9890
Formation of tubulin folding intermediates by CCT/TriC 13 0.951000 9.82e-03 0.9900
Deubiquitination 188 0.953000 -2.52e-03 0.9910
Cellular response to chemical stress 111 0.958000 2.94e-03 0.9930
Intrinsic Pathway for Apoptosis 44 0.958000 -4.57e-03 0.9930
Termination of translesion DNA synthesis 28 0.958000 5.72e-03 0.9930
Pyruvate metabolism and Citric Acid (TCA) cycle 40 0.959000 -4.74e-03 0.9930
Signaling by BRAF and RAF fusions 42 0.959000 4.60e-03 0.9930
Resolution of Abasic Sites (AP sites) 31 0.962000 -4.94e-03 0.9930
Formation of the Early Elongation Complex 25 0.967000 -4.73e-03 0.9930
Formation of the HIV-1 Early Elongation Complex 25 0.967000 -4.73e-03 0.9930
Amino acids regulate mTORC1 35 0.968000 -3.95e-03 0.9930
RND2 GTPase cycle 32 0.969000 -4.00e-03 0.9930
Nephrin family interactions 14 0.969000 6.03e-03 0.9930
Insulin processing 14 0.969000 6.02e-03 0.9930
PI3K Cascade 18 0.969000 -5.23e-03 0.9930
RNA Polymerase I Promoter Escape 25 0.970000 4.34e-03 0.9930
Signalling to RAS 12 0.970000 6.21e-03 0.9930
Netrin-1 signaling 24 0.972000 4.16e-03 0.9930
Regulation of TNFR1 signaling 30 0.973000 3.64e-03 0.9930
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 13 0.975000 -5.09e-03 0.9930
RAS processing 13 0.975000 5.09e-03 0.9930
Negative regulation of the PI3K/AKT network 53 0.977000 2.25e-03 0.9930
Nuclear Receptor transcription pathway 26 0.978000 3.13e-03 0.9930
DDX58/IFIH1-mediated induction of interferon-alpha/beta 56 0.979000 2.05e-03 0.9930
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 65 0.979000 1.88e-03 0.9930
Toll Like Receptor 2 (TLR2) Cascade 65 0.979000 1.88e-03 0.9930
Toll Like Receptor TLR1:TLR2 Cascade 65 0.979000 1.88e-03 0.9930
Toll Like Receptor TLR6:TLR2 Cascade 65 0.979000 1.88e-03 0.9930
Signaling by BMP 13 0.980000 3.92e-03 0.9930
Glycosphingolipid metabolism 25 0.982000 -2.54e-03 0.9930
Nucleotide Excision Repair 98 0.982000 1.29e-03 0.9930
TICAM1, RIP1-mediated IKK complex recruitment 17 0.983000 -2.90e-03 0.9930
Synthesis of PA 17 0.984000 -2.81e-03 0.9930
Hemostasis 292 0.986000 -6.14e-04 0.9930
Signaling by Leptin 10 0.986000 3.16e-03 0.9930
S33 mutants of beta-catenin aren’t phosphorylated 13 0.989000 2.26e-03 0.9930
S37 mutants of beta-catenin aren’t phosphorylated 13 0.989000 2.26e-03 0.9930
S45 mutants of beta-catenin aren’t phosphorylated 13 0.989000 2.26e-03 0.9930
Signaling by CTNNB1 phospho-site mutants 13 0.989000 2.26e-03 0.9930
Signaling by GSK3beta mutants 13 0.989000 2.26e-03 0.9930
T41 mutants of beta-catenin aren’t phosphorylated 13 0.989000 2.26e-03 0.9930
NCAM signaling for neurite out-growth 23 0.991000 -1.40e-03 0.9940
PKMTs methylate histone lysines 24 0.991000 1.28e-03 0.9940
Cardiac conduction 40 0.994000 7.07e-04 0.9960
Beta-catenin phosphorylation cascade 15 0.996000 -7.85e-04 0.9970
Rab regulation of trafficking 85 0.999000 -4.33e-05 0.9990


Detailed Gene set reports



Cell Cycle

Cell Cycle
114
set Cell Cycle
setSize 482
pANOVA 3.1e-05
s.dist 0.112
p.adjustANOVA 0.0353



Top enriched genes

Top 20 genes
GeneID Gene Rank
TERT 6752
TUBGCP3 6638
MND1 6612
TUBGCP6 6580
NEDD1 6562
TUBA4B 6556
MYBL2 6528
CEP76 6523
CKS1B 6522
RCC1 6472
TAOK1 6421
LIN9 6417
PDS5A 6341
HSPA2 6296
CCNB1 6272
ACTR1A 6228
SKP1 6201
CDC7 6193
TUBB 6157
POLD1 6147

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TERT 6752
TUBGCP3 6638
MND1 6612
TUBGCP6 6580
NEDD1 6562
TUBA4B 6556
MYBL2 6528
CEP76 6523
CKS1B 6522
RCC1 6472
TAOK1 6421
LIN9 6417
PDS5A 6341
HSPA2 6296
CCNB1 6272
ACTR1A 6228
SKP1 6201
CDC7 6193
TUBB 6157
POLD1 6147
PPP1R12A 6142
RFWD2 6115
USO1 6098
POLE3 6048
PSME4 5997
HMMR 5977
LBR 5971
NCAPG2 5943
AURKB 5907
PAFAH1B1 5904
NCAPD3 5898
PRIM1 5893
PPP6C 5865
MNAT1 5844
SIRT2 5840
CCNH 5835
INCENP 5832
STAG1 5829
RBL1 5755
YWHAZ 5742
CHTF8 5720
RFC5 5700
NDEL1 5672
RAB1A 5660
DBF4 5651
PRKCB 5627
RBX1 5617
CENPJ 5613
POM121 5593
DCTN3 5566
NUP85 5526
PSMD3 5506
PIAS4 5457
PSMC5 5418
TNPO1 5407
ATM 5395
PCBP4 5393
PPP2CB 5390
ODF2 5376
CENPF 5351
MDM2 5322
MCM5 5311
RNF168 5302
TERF2IP 5281
UBE2I 5265
ANAPC2 5252
NCAPD2 5235
RAD17 5216
GSK3B 5172
DHFR 5161
PSMB8 5160
KIF18A 5152
DMC1 5130
OPTN 5114
PSMA2 5110
PSMA1 5104
NOP10 5068
CLSPN 5062
CCND3 5056
NUDC 5046
POLR2H 5045
ATR 5030
DYNC1H1 5029
LEMD2 5022
CEP78 5013
TINF2 5012
VRK1 4985
MLH3 4962
XPO1 4933
PSMD13 4927
SDCCAG8 4907
PSMB9 4898
CEP250 4881
AKT1 4880
SEC13 4873
NEK7 4859
RFC3 4829
DYNLL2 4788
PSMB3 4780
CDC25B 4768
GTSE1 4753
NEK9 4727
CKAP5 4720
PDS5B 4713
DYRK1A 4712
MDM4 4702
ANAPC4 4698
SEH1L 4691
NUP205 4686
CHMP7 4685
CCNB2 4682
HAUS8 4673
PMF1 4661
LPIN2 4654
KIF2C 4652
MCM2 4651
RAB2A 4608
DYNLL1 4607
EP300 4582
FZR1 4578
NUP37 4573
ANAPC1 4561
NUP43 4558
NSL1 4556
RAD51 4554
SPAST 4541
CDC14A 4537
CCNE2 4526
YWHAB 4484
PRIM2 4469
CCND2 4468
CENPA 4463
RPA3 4462
CDKN1B 4449
PPP2CA 4425
NHP2 4423
SMC3 4416
MAD1L1 4397
HSP90AA1 4393
AURKA 4365
KPNB1 4322
PSMC6 4301
PSMD11 4285
CEP63 4259
CC2D1B 4256
PCM1 4253
SMC4 4224
CENPP 4188
PSMA3 4184
LPIN1 4157
NIPBL 4140
PSMA5 4135
PIF1 4076
DIDO1 4058
RUVBL1 4056
NDC80 4054
MDC1 4046
ATRIP 4019
BLZF1 4015
WRN 3981
TUBA1C 3980
PRKCA 3971
WEE1 3951
POM121C 3938
POLD4 3890
WRAP53 3872
CDK6 3867
MIS12 3865
AKAP9 3852
RFC4 3851
SHQ1 3844
CDC25C 3835
LMNB1 3817
B9D2 3803
POLA2 3753
CHMP2A 3751
KAT5 3717
CDKN2D 3696
FAM175A 3673
CEP70 3663
POLR2G 3633
DAXX 3610
RBBP8 3582
PPP2R1B 3568
CHMP4A 3557
YWHAG 3556
TP53 3539
PSMA7 3526
PSMD14 3518
NUP54 3515
NUP188 3510
CDK11B 3493
CENPM 3488
CCNA2 3487
PSMD2 3485
CENPN 3464
LIN54 3438
YWHAH 3424
NCAPH 3362
POLR2A 3361
PPP1R12B 3352
SYNE2 3284
DSN1 3232
PSMD9 3215
CDCA5 3175
PPP2R5C 3153
RCC2 3142
ACD 3133
E2F2 3131
CSNK2B 3108
E2F5 3107
APITD1 3086
UBE2V2 3079
TUBGCP2 3059
BLM 3040
NUP50 2999
PPME1 2989
TYMS 2982
PSMD7 2963
NEK2 2954
HAUS6 2952
RAE1 2950
RAB8A 2929
BIRC5 2843
ENSA 2792
NCAPH2 2787
HDAC1 2753
CENPL 2744
HUS1 2673
POLR2C 2661
NME7 2648
NUP210 2605
ESPL1 2600
RAD1 2568
CEP135 2548
NCAPG 2538
ZWINT 2506
POLR2F 2490
RB1 2475
NUP214 2474
GAR1 2470
CDK1 2450
DYNC1I2 2439
MCM6 2421
RAD50 2399
E2F4 2395
MCM8 2389
PSMC3IP 2386
PSME1 2379
AAAS 2354
PSME2 2344
SMC1B 2336
VPS4A 2335
CENPK 2332
LEMD3 2330
PSMB6 2326
LIN37 2309
RAD9A 2307
ANAPC7 2305
MSH5 2300
POLE2 2292
MCM3 2291
TPR 2275
CENPO 2243
CSNK1D 2239
EXO1 2233
SKA2 2224
CEP192 2199
POLD3 2184
CLIP1 2164
NUP98 2149
KIF23 2145
NUP153 2123
ESCO2 2107
RAB1B 2090
DYNC1LI1 2070
MCPH1 2053
CENPT 2029
E2F1 2003
FBXO5 1996
NUP62 1978
CDK7 1957
PLK4 1944
BANF1 1929
TOP3A 1914
PSMD6 1908
CDK4 1863
TUBA1B 1859
FBXL18 1835
BRCA2 1803
BUB1B 1793
TERF2 1787
CEP152 1653
POLR2E 1641
SMC2 1629
RPA1 1606
EML4 1602
PSMC4 1563
FEN1 1554
CLASP1 1549
PPP2R5A 1532
UBA52 1530
GOLGA2 1523
LCMT1 1427
MAD2L1 1421
PSMD8 1397
HAUS2 1391
RBL2 1390
FOXM1 1373
MCM7 1350
SPC24 1317
GINS4 1306
POLR2B 1297
KIF2A 1265
E2F6 1256
POLR2D 1251
PSMB1 1218
CHMP2B 1172
HAUS4 1165
PCNA 1160
PPP2R2A 1125
TUBG2 1108
ANAPC5 1095
PPP2R5B 1078
CDK2 1071
POLR2I 1067
TK1 1054
MCM10 998
TERF1 936
NUP107 902
CENPE 899
PPP2R5E 863
GMNN 809
TOP2A 803
CENPQ 788
NUP155 778
NBN 771
TUBA4A 757
PSMD4 754
MAX 727
CEP164 713
YWHAQ 696
POLE4 682
TP53BP1 673
ARPP19 650
CHMP6 638
TMPO 629
PSMC1 611
ANAPC11 601
MCM4 581
CDCA8 538
PSMD1 458
STAG3 396
GINS3 383
RPS27A 373
TPX2 313
RBBP4 290
TUBA1A 281
CDKN2C 242
PSMA6 230
JAK2 227
OIP5 223
PSME3 210
NDE1 191
SMARCA5 184
DSCC1 159
PTTG1 144
CDC23 84
FKBPL 39
PSMD12 20
ANKLE2 -8
UBB -13
RAD21 -54
HJURP -57
NEK6 -68
BARD1 -100
PPP1CC -109
PLK1 -118
ZW10 -133
HAUS1 -139
UBE2D1 -157
PSMB10 -165
RANGAP1 -174
CSNK2A2 -188
PHF20 -258
STRA13 -275
CDC6 -325
BRCA1 -334
RNF8 -345
CHEK2 -348
ANAPC10 -361
SYCE2 -376
BUB3 -425
SRC -427
DYNC1LI2 -456
LIN52 -467
PSMB7 -481
AKT2 -487
CDC20 -491
ABL1 -538
TOPBP1 -548
PPP1CB -558
GINS1 -595
POLR2K -599
CDKN1A -682
GORASP2 -692
DNA2 -708
CSNK1E -729
H2AFX -738
SKP2 -743
CCNE1 -755
RRM2 -786
CCND1 -822
PKMYT1 -825
CHMP4B -830
CHEK1 -889
RAD9B -903
NUP133 -1034
POLD2 -1045
CDC25A -1059
UBC -1067
RUVBL2 -1068
PSMB5 -1101
NUP160 -1133
MAPK1 -1146
CHTF18 -1160
AHCTF1 -1162
RAN -1174
LIG1 -1221
MAPRE1 -1239
RANBP2 -1283
PRKACA -1287
UBE2E1 -1323
BTRC -1346
RSF1 -1349
NUP35 -1373
RFC2 -1443
SPC25 -1447
MAPK3 -1492
RTEL1 -1540
CDKN2A -1553
SYNE1 -1586
ZWILCH -1593
ALMS1 -1625
HAUS5 -1633
CDT1 -1667
HSP90AB1 -1669
VRK2 -1683
UBE2C -1688
E2F3 -1726
CLASP2 -1727
PSMC3 -1757
UBE2N -1821
PCNT -1852
POLE -1862
CENPH -1863
BUB1 -1899
ESCO1 -1983
SUMO1 -2075
PPP2R5D -2111
NUP93 -2168
BRIP1 -2180
YWHAE -2211
KNTC1 -2217
ITGB3BP -2272
PHLDA1 -2341
CDC16 -2388
ANKRD28 -2389
NUF2 -2397
TUBB2A -2479
CDK5RAP2 -2525
DCTN2 -2552
TFDP1 -2589
CDK11A -2613
NUMA1 -2615
PSMF1 -2618
LMNA -2632
TUBGCP5 -2707
SET -2876
SFN -2958
CUL1 -2993
REC8 -3078


Transmission across Chemical Synapses

Transmission across Chemical Synapses
1076
set Transmission across Chemical Synapses
setSize 93
pANOVA 0.00013
s.dist -0.23
p.adjustANOVA 0.0498



Top enriched genes

Top 20 genes
GeneID Gene Rank
GLUL -3101
GIT1 -3090
PRKAR1B -3015
ADCY7 -2990
DNAJC5 -2896
ABAT -2789
HRAS -2761
RPS6KA1 -2723
CAMK1 -2658
GNB1 -2592
CHRNE -2588
SLC1A1 -2572
PRKAR2A -2557
GRIN1 -2485
AP2S1 -2469
GABBR1 -2447
RAB3A -2441
GRIN2C -2408
GRIN2D -2134
CAMKK2 -2051

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GLUL -3101
GIT1 -3090
PRKAR1B -3015
ADCY7 -2990
DNAJC5 -2896
ABAT -2789
HRAS -2761
RPS6KA1 -2723
CAMK1 -2658
GNB1 -2592
CHRNE -2588
SLC1A1 -2572
PRKAR2A -2557
GRIN1 -2485
AP2S1 -2469
GABBR1 -2447
RAB3A -2441
GRIN2C -2408
GRIN2D -2134
CAMKK2 -2051
COMT -1986
ADCY4 -1935
NBEA -1866
PPFIA3 -1864
APBA1 -1859
ARL6IP5 -1851
UNC13B -1692
PPM1F -1585
MAPK3 -1492
PRKACA -1287
DLG4 -1172
PRKAA1 -1152
MAPK1 -1146
PLCB3 -1041
CAMK2G -829
LIN7B -741
CALM1 -703
AP2M1 -611
PPFIA1 -600
PICK1 -471
SRC -427
GLS -61
KRAS 138
MAPT 201
ALDH5A1 297
GNB4 355
CREB1 472
VAMP2 543
LIN7C 606
SLC38A2 677
NRGN 776
CHRNA5 853
NPTN 894
ARHGEF7 1038
GNAI3 1076
STX1A 1081
MYO6 1092
PLCB2 1115
NCALD 1257
GNAI2 1325
PRKAB2 1621
RAC1 1706
NAAA 1733
STXBP1 1842
LRTOMT 2195
PRKACB 2348
ADCY9 2546
GNG4 2653
CAMK4 2726
DLG1 2874
GNB5 2913
KIF17 2947
RPS6KA2 3112
GNG5 3683
PDPK1 3800
PRKCA 3971
CACNA2D2 3989
GNB2 4217
GNG2 4308
KPNA2 4362
GNAL 4412
PRKAG2 4444
CAMKK1 4543
PRKAG1 4778
AP2A1 4882
PRKAR1A 4900
MDM2 5322
PRKCB 5627
PRKAB1 5662
CAMK2D 6135
GNG12 6415
SLC38A1 6458
CHRNB4 6666


Neuronal System

Neuronal System
591
set Neuronal System
setSize 127
pANOVA 0.000157
s.dist -0.195
p.adjustANOVA 0.0498



Top enriched genes

Top 20 genes
GeneID Gene Rank
GLUL -3101
GIT1 -3090
PRKAR1B -3015
ADCY7 -2990
PPFIBP2 -2943
DNAJC5 -2896
KCNS1 -2810
ABAT -2789
HRAS -2761
RPS6KA1 -2723
CAMK1 -2658
GNB1 -2592
CHRNE -2588
SLC1A1 -2572
PRKAR2A -2557
GRIN1 -2485
AP2S1 -2469
GABBR1 -2447
RAB3A -2441
GRIN2C -2408

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GLUL -3101
GIT1 -3090
PRKAR1B -3015
ADCY7 -2990
PPFIBP2 -2943
DNAJC5 -2896
KCNS1 -2810
ABAT -2789
HRAS -2761
RPS6KA1 -2723
CAMK1 -2658
GNB1 -2592
CHRNE -2588
SLC1A1 -2572
PRKAR2A -2557
GRIN1 -2485
AP2S1 -2469
GABBR1 -2447
RAB3A -2441
GRIN2C -2408
KCNK6 -2361
KCNAB2 -2218
GRIN2D -2134
CAMKK2 -2051
KCNH4 -2013
COMT -1986
ADCY4 -1935
FLOT1 -1915
NBEA -1866
PPFIA3 -1864
APBA1 -1859
KCNQ5 -1858
ARL6IP5 -1851
UNC13B -1692
EPB41L5 -1671
PPM1F -1585
MAPK3 -1492
KCNMB4 -1481
PRKACA -1287
DLG4 -1172
PRKAA1 -1152
MAPK1 -1146
PLCB3 -1041
RTN3 -895
CAMK2G -829
LIN7B -741
CALM1 -703
DLGAP3 -623
KCNJ11 -617
AP2M1 -611
PPFIA1 -600
DLGAP4 -556
PICK1 -471
SRC -427
KCNQ4 -301
GLS -61
KRAS 138
MAPT 201
ALDH5A1 297
GNB4 355
PDLIM5 384
CREB1 472
VAMP2 543
KCNG3 586
LIN7C 606
SLC38A2 677
NRGN 776
SHARPIN 818
CHRNA5 853
NPTN 894
ARHGEF7 1038
GNAI3 1076
STX1A 1081
MYO6 1092
PLCB2 1115
HCN3 1187
EPB41 1247
NCALD 1257
GNAI2 1325
KCNH2 1548
PRKAB2 1621
RAC1 1706
NAAA 1733
FLOT2 1826
STXBP1 1842
IL1RAP 1938
LRTOMT 2195
PRKACB 2348
DBNL 2529
ADCY9 2546
GNG4 2653
CAMK4 2726
DLG1 2874
GNB5 2913
KIF17 2947
LRFN3 3046
RPS6KA2 3112
KCNN4 3192
PANX1 3389
GNG5 3683
PDPK1 3800
PRKCA 3971
CACNA2D2 3989
GNB2 4217
GNG2 4308
KPNA2 4362
GNAL 4412
PRKAG2 4444
APBA2 4493
CAMKK1 4543
PRKAG1 4778
AP2A1 4882
PRKAR1A 4900
HOMER1 5039
MDM2 5322
PPFIBP1 5366
DLGAP1 5553
PRKCB 5627
PRKAB1 5662
CAMK2D 6135
LRFN4 6309
KCNA3 6350
GNG12 6415
SLC38A1 6458
KCNC4 6599
CHRNB4 6666
APBA3 6751


Neurotransmitter release cycle

Neurotransmitter release cycle
593
set Neurotransmitter release cycle
setSize 18
pANOVA 0.000175
s.dist -0.511
p.adjustANOVA 0.0498



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNAJC5 -2896
ABAT -2789
SLC1A1 -2572
RAB3A -2441
PPFIA3 -1864
APBA1 -1859
ARL6IP5 -1851
UNC13B -1692
LIN7B -741
PPFIA1 -600
GLS -61
ALDH5A1 297
VAMP2 543
LIN7C 606
SLC38A2 677
STX1A 1081
NAAA 1733
STXBP1 1842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNAJC5 -2896
ABAT -2789
SLC1A1 -2572
RAB3A -2441
PPFIA3 -1864
APBA1 -1859
ARL6IP5 -1851
UNC13B -1692
LIN7B -741
PPFIA1 -600
GLS -61
ALDH5A1 297
VAMP2 543
LIN7C 606
SLC38A2 677
STX1A 1081
NAAA 1733
STXBP1 1842


Cell Cycle, Mitotic

Cell Cycle, Mitotic
116
set Cell Cycle, Mitotic
setSize 390
pANOVA 0.000277
s.dist 0.108
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBGCP3 6638
TUBGCP6 6580
NEDD1 6562
TUBA4B 6556
MYBL2 6528
CEP76 6523
CKS1B 6522
RCC1 6472
TAOK1 6421
LIN9 6417
PDS5A 6341
CCNB1 6272
ACTR1A 6228
SKP1 6201
CDC7 6193
TUBB 6157
POLD1 6147
PPP1R12A 6142
USO1 6098
POLE3 6048

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBGCP3 6638
TUBGCP6 6580
NEDD1 6562
TUBA4B 6556
MYBL2 6528
CEP76 6523
CKS1B 6522
RCC1 6472
TAOK1 6421
LIN9 6417
PDS5A 6341
CCNB1 6272
ACTR1A 6228
SKP1 6201
CDC7 6193
TUBB 6157
POLD1 6147
PPP1R12A 6142
USO1 6098
POLE3 6048
PSME4 5997
HMMR 5977
LBR 5971
NCAPG2 5943
AURKB 5907
PAFAH1B1 5904
NCAPD3 5898
PRIM1 5893
MNAT1 5844
SIRT2 5840
CCNH 5835
INCENP 5832
STAG1 5829
RBL1 5755
RFC5 5700
NDEL1 5672
RAB1A 5660
DBF4 5651
PRKCB 5627
RBX1 5617
CENPJ 5613
POM121 5593
DCTN3 5566
NUP85 5526
PSMD3 5506
PSMC5 5418
TNPO1 5407
PPP2CB 5390
ODF2 5376
CENPF 5351
MCM5 5311
UBE2I 5265
ANAPC2 5252
NCAPD2 5235
GSK3B 5172
DHFR 5161
PSMB8 5160
KIF18A 5152
OPTN 5114
PSMA2 5110
PSMA1 5104
CCND3 5056
NUDC 5046
DYNC1H1 5029
LEMD2 5022
CEP78 5013
VRK1 4985
XPO1 4933
PSMD13 4927
SDCCAG8 4907
PSMB9 4898
CEP250 4881
AKT1 4880
SEC13 4873
NEK7 4859
RFC3 4829
DYNLL2 4788
PSMB3 4780
CDC25B 4768
GTSE1 4753
NEK9 4727
CKAP5 4720
PDS5B 4713
DYRK1A 4712
ANAPC4 4698
SEH1L 4691
NUP205 4686
CHMP7 4685
CCNB2 4682
HAUS8 4673
PMF1 4661
LPIN2 4654
KIF2C 4652
MCM2 4651
RAB2A 4608
DYNLL1 4607
EP300 4582
FZR1 4578
NUP37 4573
ANAPC1 4561
NUP43 4558
NSL1 4556
SPAST 4541
CDC14A 4537
CCNE2 4526
PRIM2 4469
CCND2 4468
CENPA 4463
RPA3 4462
CDKN1B 4449
PPP2CA 4425
SMC3 4416
MAD1L1 4397
HSP90AA1 4393
AURKA 4365
KPNB1 4322
PSMC6 4301
PSMD11 4285
CEP63 4259
CC2D1B 4256
PCM1 4253
SMC4 4224
CENPP 4188
PSMA3 4184
LPIN1 4157
NIPBL 4140
PSMA5 4135
NDC80 4054
BLZF1 4015
TUBA1C 3980
PRKCA 3971
WEE1 3951
POM121C 3938
POLD4 3890
CDK6 3867
MIS12 3865
AKAP9 3852
RFC4 3851
CDC25C 3835
LMNB1 3817
B9D2 3803
POLA2 3753
CHMP2A 3751
CDKN2D 3696
CEP70 3663
PPP2R1B 3568
CHMP4A 3557
YWHAG 3556
TP53 3539
PSMA7 3526
PSMD14 3518
NUP54 3515
NUP188 3510
CDK11B 3493
CENPM 3488
CCNA2 3487
PSMD2 3485
CENPN 3464
LIN54 3438
NCAPH 3362
PPP1R12B 3352
DSN1 3232
PSMD9 3215
CDCA5 3175
PPP2R5C 3153
RCC2 3142
E2F2 3131
CSNK2B 3108
E2F5 3107
APITD1 3086
TUBGCP2 3059
NUP50 2999
PPME1 2989
TYMS 2982
PSMD7 2963
NEK2 2954
HAUS6 2952
RAE1 2950
RAB8A 2929
BIRC5 2843
ENSA 2792
NCAPH2 2787
HDAC1 2753
CENPL 2744
NME7 2648
NUP210 2605
ESPL1 2600
CEP135 2548
NCAPG 2538
ZWINT 2506
RB1 2475
NUP214 2474
CDK1 2450
DYNC1I2 2439
MCM6 2421
E2F4 2395
MCM8 2389
PSME1 2379
AAAS 2354
PSME2 2344
VPS4A 2335
CENPK 2332
LEMD3 2330
PSMB6 2326
LIN37 2309
ANAPC7 2305
POLE2 2292
MCM3 2291
TPR 2275
CENPO 2243
CSNK1D 2239
SKA2 2224
CEP192 2199
POLD3 2184
CLIP1 2164
NUP98 2149
KIF23 2145
NUP153 2123
ESCO2 2107
RAB1B 2090
DYNC1LI1 2070
MCPH1 2053
CENPT 2029
E2F1 2003
FBXO5 1996
NUP62 1978
CDK7 1957
PLK4 1944
BANF1 1929
PSMD6 1908
CDK4 1863
TUBA1B 1859
FBXL18 1835
BUB1B 1793
CEP152 1653
SMC2 1629
RPA1 1606
EML4 1602
PSMC4 1563
FEN1 1554
CLASP1 1549
PPP2R5A 1532
UBA52 1530
GOLGA2 1523
LCMT1 1427
MAD2L1 1421
PSMD8 1397
HAUS2 1391
RBL2 1390
FOXM1 1373
MCM7 1350
SPC24 1317
GINS4 1306
KIF2A 1265
E2F6 1256
PSMB1 1218
CHMP2B 1172
HAUS4 1165
PCNA 1160
PPP2R2A 1125
TUBG2 1108
ANAPC5 1095
PPP2R5B 1078
CDK2 1071
TK1 1054
MCM10 998
NUP107 902
CENPE 899
PPP2R5E 863
GMNN 809
TOP2A 803
CENPQ 788
NUP155 778
TUBA4A 757
PSMD4 754
MAX 727
CEP164 713
POLE4 682
ARPP19 650
CHMP6 638
TMPO 629
PSMC1 611
ANAPC11 601
MCM4 581
CDCA8 538
PSMD1 458
GINS3 383
RPS27A 373
TPX2 313
RBBP4 290
TUBA1A 281
CDKN2C 242
PSMA6 230
JAK2 227
PSME3 210
NDE1 191
PTTG1 144
CDC23 84
FKBPL 39
PSMD12 20
ANKLE2 -8
UBB -13
RAD21 -54
NEK6 -68
PPP1CC -109
PLK1 -118
ZW10 -133
HAUS1 -139
UBE2D1 -157
PSMB10 -165
RANGAP1 -174
CSNK2A2 -188
CDC6 -325
ANAPC10 -361
BUB3 -425
SRC -427
DYNC1LI2 -456
LIN52 -467
PSMB7 -481
AKT2 -487
CDC20 -491
ABL1 -538
PPP1CB -558
GINS1 -595
CDKN1A -682
GORASP2 -692
DNA2 -708
CSNK1E -729
H2AFX -738
SKP2 -743
CCNE1 -755
RRM2 -786
CCND1 -822
PKMYT1 -825
CHMP4B -830
NUP133 -1034
POLD2 -1045
CDC25A -1059
UBC -1067
PSMB5 -1101
NUP160 -1133
MAPK1 -1146
AHCTF1 -1162
RAN -1174
LIG1 -1221
MAPRE1 -1239
RANBP2 -1283
PRKACA -1287
UBE2E1 -1323
BTRC -1346
NUP35 -1373
RFC2 -1443
SPC25 -1447
MAPK3 -1492
CDKN2A -1553
ZWILCH -1593
ALMS1 -1625
HAUS5 -1633
CDT1 -1667
HSP90AB1 -1669
VRK2 -1683
UBE2C -1688
E2F3 -1726
CLASP2 -1727
PSMC3 -1757
PCNT -1852
POLE -1862
CENPH -1863
BUB1 -1899
ESCO1 -1983
SUMO1 -2075
PPP2R5D -2111
NUP93 -2168
YWHAE -2211
KNTC1 -2217
ITGB3BP -2272
PHLDA1 -2341
CDC16 -2388
NUF2 -2397
TUBB2A -2479
CDK5RAP2 -2525
DCTN2 -2552
TFDP1 -2589
CDK11A -2613
NUMA1 -2615
PSMF1 -2618
LMNA -2632
TUBGCP5 -2707
SET -2876
CUL1 -2993


Metabolism of RNA

Metabolism of RNA
504
set Metabolism of RNA
setSize 498
pANOVA 0.000388
s.dist 0.0942
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPIL6 6689
PUS1 6583
U2AF1L4 6502
TRMT12 6460
HNRNPH1 6459
TSEN54 6410
CNOT4 6398
SNRNP200 6366
CTU2 6346
HNRNPR 6282
CSTF1 6211
ADAT3 6196
ADAT1 6194
TTC37 6192
CDC40 6113
BYSL 6111
WDR43 6105
CRNKL1 6082
EXOSC8 6064
RPS11 6042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPIL6 6689
PUS1 6583
U2AF1L4 6502
TRMT12 6460
HNRNPH1 6459
TSEN54 6410
CNOT4 6398
SNRNP200 6366
CTU2 6346
HNRNPR 6282
CSTF1 6211
ADAT3 6196
ADAT1 6194
TTC37 6192
CDC40 6113
BYSL 6111
WDR43 6105
CRNKL1 6082
EXOSC8 6064
RPS11 6042
PSME4 5997
WDR61 5946
PRKCD 5933
ZFP36L1 5905
SRRM2 5878
RPL8 5868
FYTTD1 5845
MNAT1 5844
UPF3A 5839
CCNH 5835
RBM17 5818
DDX5 5815
SNRPD2 5812
ZCCHC11 5781
RPL36AL 5773
RPL31 5771
WDR77 5761
YWHAZ 5742
ISG20L2 5735
RPL39L 5706
ZFP36 5694
SF3A1 5669
RRP9 5668
BUD31 5663
SNRPB 5645
LSM4 5635
CPSF2 5634
RPS15A 5624
POM121 5593
FUS 5569
NUDT21 5559
NUP85 5526
PSMD3 5506
ADAR 5502
RPP38 5497
SF3B5 5471
RPL10A 5455
PSMC5 5418
TNPO1 5407
SF3A2 5388
DDX49 5371
NSUN2 5364
RPL14 5360
TRDMT1 5329
WDR3 5316
LSM1 5279
ISY1 5271
SNRNP27 5262
TRIT1 5230
SMG7 5198
PSMB8 5160
SNRPD1 5156
DHX37 5147
TSEN2 5121
PSMA2 5110
PSMA1 5104
RPP40 5100
IGF2BP3 5091
TRNT1 5085
NOP10 5068
RPS27L 5057
POP1 5051
POLR2H 5045
RPL29 4990
NIP7 4984
PWP2 4980
RPL7 4967
CNOT3 4938
XPO1 4933
PSMD13 4927
PSMB9 4898
AKT1 4880
SEC13 4873
PRPF6 4827
SLU7 4816
FAM98B 4802
UTP3 4792
PSMB3 4780
ACTB 4760
NOP58 4754
FAU 4740
CNOT6L 4701
SEH1L 4691
NUP205 4686
ETF1 4663
HNRNPD 4662
RPL13 4655
DDX20 4653
SNRNP25 4650
WTAP 4617
ERI1 4581
NUP37 4573
NUP43 4558
PPIH 4546
MPHOSPH10 4534
RPLP0 4527
EIF4A3 4502
C2orf49 4492
PRPF8 4488
YWHAB 4484
SLBP 4482
PPP2CA 4425
NHP2 4423
KHSRP 4404
SNRPD3 4403
NXF1 4304
SNW1 4302
PSMC6 4301
WBP11 4297
PSMD11 4285
RPS29 4263
PABPC1 4238
DCP2 4207
PCBP2 4187
PSMA3 4184
PSMA5 4135
CCAR1 4117
RPL41 4115
TRMU 4103
SNRNP35 4093
CD44 4090
HNRNPUL1 4088
CDKAL1 4062
PLRG1 4035
RPS5 4030
SYMPK 4027
EIF4G1 4004
PRKCA 3971
DIS3 3964
SF3B2 3956
POM121C 3938
TSEN15 3923
TBL3 3907
RPS10 3900
THOC7 3898
DCPS 3883
POP4 3877
POP5 3856
EIF4A1 3847
SNRPB2 3845
RPS26 3830
DCAF13 3821
CPSF3 3820
RPL11 3810
RPS3A 3771
CLP1 3767
HBS1L 3760
EIF4B 3758
NOP14 3743
RPP30 3731
PELP1 3720
RPL4 3711
TXNL4A 3705
TEX10 3700
WDR75 3688
RNPS1 3685
DHX16 3655
WDR36 3648
ADAT2 3643
POLR2G 3633
GTF2H4 3621
CPSF4 3597
PDCD7 3565
PSMA7 3526
PSMD14 3518
RPS9 3516
NUP54 3515
NUP188 3510
PSMD2 3485
EXOSC7 3484
TFB1M 3453
GNL3 3435
SNRPA 3379
RPL3 3364
POLR2A 3361
TNFSF13 3354
HNRNPA0 3243
SKIV2L 3233
EXOSC4 3231
PSMD9 3215
PPIL3 3210
UPF2 3206
PPIL1 3201
LSM6 3191
DDX21 3188
DHX9 3182
FIP1L1 3181
RNGTT 3170
RPL23 3169
CTU1 3145
AQR 3130
SNRNP70 3062
NUP50 2999
HNRNPF 2984
NCBP2 2973
PSMD7 2963
RAE1 2950
RPL36 2924
NOL12 2920
SUPT5H 2917
TRMT1 2891
NCL 2823
TRMT11 2814
RPS12 2813
SNRPE 2801
SNRPG 2782
RPS7 2759
GTF2F2 2754
THOC1 2712
CDC5L 2708
RPLP2 2663
POLR2C 2661
RPL37 2639
MPHOSPH6 2630
RPL35 2622
SMNDC1 2616
NUP210 2605
DDX52 2602
PABPN1 2534
EXOSC2 2530
GTF2H5 2512
NOP56 2511
MRM1 2510
MAPKAPK2 2498
RPP14 2495
POLR2F 2490
PNRC2 2483
NUP214 2474
GAR1 2470
RPL32 2458
XRN2 2453
NCBP1 2448
PAPOLA 2436
RPS15 2414
EIF4A2 2412
SF3A3 2407
THADA 2397
PSME1 2379
WDR33 2377
RPS28 2374
RIOK2 2370
NOL11 2367
CNOT6 2360
AAAS 2354
PSME2 2344
PSMB6 2326
HNRNPK 2280
TPR 2275
UTP15 2250
CSNK1D 2239
RPS3 2229
RPS6 2203
CNOT10 2180
RPS23 2178
NUP98 2149
PUF60 2132
NUP153 2123
HEATR1 2084
U2AF2 2075
LSM5 2041
YBX1 2033
LSM11 2016
NUP62 1978
PDCD11 1969
CDK7 1957
EXOSC5 1943
MAPK14 1942
PSMD6 1908
RPL6 1906
SMG1 1838
RPL22 1781
PUS7 1771
CPSF1 1761
RPL18 1752
UTP20 1726
POLDIP3 1702
DDX6 1690
HNRNPL 1676
RPS19 1660
POLR2E 1641
DDX46 1628
DDX1 1620
RPS16 1615
PSMC4 1563
EXOSC10 1561
RPL34 1552
SMG5 1537
UBA52 1530
RPL27A 1519
PRPF19 1425
PSMD8 1397
SF1 1384
RNU11 1371
METTL14 1352
RPL26 1337
ZCCHC6 1333
HNRNPA2B1 1320
POLR2B 1297
RPL28 1296
EXOSC6 1276
DDX23 1255
POLR2D 1251
PSMB1 1218
ENPP2 1215
DCP1A 1204
EBNA1BP2 1196
ALKBH8 1192
NXT1 1191
RPL37A 1174
TRMT61B 1149
GEMIN7 1126
PPP2R2A 1125
THG1L 1098
POLR2I 1067
C1D 1064
PPIL4 1024
MTO1 926
PTBP1 921
TRMT61A 918
SYF2 917
RPP21 906
NUP107 902
RNPC3 893
METTL1 878
HNRNPU 860
NSUN6 846
HSPA1A 832
EIF4E 798
NUP155 778
CNOT8 762
PSMD4 754
EXOSC3 748
SNRNP40 694
RPL26L1 666
LTV1 662
PSMC1 611
EFTUD2 556
CNOT1 515
CWC15 500
PATL1 498
UPF1 478
PSMD1 458
PRCC 417
RPS25 393
IMP3 388
RPSA 374
RPS27A 373
RIOK3 348
DNAJC8 341
PNO1 266
RNMT 258
PSMA6 230
SNRNP48 225
PSME3 210
PCBP1 182
CHERP 150
SRRM1 143
RPS24 131
ERCC3 128
EDC3 79
PRMT5 38
PPWD1 37
PARN 35
PSMD12 20
UBB -13
NOL6 -40
ADARB1 -65
RPS18 -105
RPS20 -114
CASC3 -120
SRRT -122
FCF1 -123
NOB1 -131
PSMB10 -165
PAN2 -178
GEMIN6 -204
IMP4 -220
RNU12 -300
PPIE -319
RRP1 -355
TYW3 -388
XAB2 -396
HNRNPC -444
RPL17 -480
PSMB7 -481
RRP7A -483
NOP2 -489
RIOK1 -497
TNKS1BP1 -517
RBM28 -522
CD2BP2 -565
LSM2 -593
POLR2K -599
GTF2F1 -601
GSPT1 -604
TSR1 -615
CWC22 -624
RPL38 -629
POP7 -644
SART1 -653
CSNK1E -729
GTPBP3 -733
NSUN4 -748
DDX42 -750
TP53RK -769
WBSCR22 -787
CLNS1A -850
LSM7 -859
SNRPN -871
SNUPN -873
GEMIN5 -1005
TYW1 -1008
WDR12 -1014
TPRKB -1024
NUP133 -1034
UBC -1067
URM1 -1083
WBP4 -1098
PSMB5 -1101
NUP160 -1133
RAN -1174
RCL1 -1205
HSPB1 -1219
LSM3 -1227
U2AF1 -1258
RANBP2 -1283
QTRT1 -1309
NUP35 -1373
PRPF3 -1404
LSM10 -1414
CNOT7 -1484
PHAX -1487
NOC4L -1501
PRPF38A -1546
WDR18 -1636
FTSJ3 -1655
RPL9 -1663
CTNNBL1 -1675
RPL23A -1715
SNRPC -1742
THOC5 -1746
ELAC2 -1752
PSMC3 -1757
TFIP11 -1766
GLE1 -1801
DDX47 -1806
SNRPA1 -1814
DCP1B -1919
USP39 -1921
UTP6 -1982
EDC4 -2072
ERCC2 -2080
PRPF31 -2121
FBL -2129
NUP93 -2168
RPLP1 -2185
GTF2H3 -2196
SF3B3 -2254
HNRNPM -2261
PES1 -2265
ANP32A -2286
BMS1 -2326
ZBTB8OS -2329
XPOT -2331
THUMPD1 -2354
SENP3 -2379
RPL15 -2423
SF3B4 -2440
RPP25 -2548
PSMF1 -2618
PAIP1 -2670
IGF2BP1 -2689
ZMAT5 -2802
PAN3 -2829
PUS3 -2850
LCMT2 -2864
SET -2876
RPS8 -2966


Cytokine Signaling in Immune system

Cytokine Signaling in Immune system
171
set Cytokine Signaling in Immune system
setSize 411
pANOVA 0.000394
s.dist 0.103
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
IL19 6750
LTA 6732
LCK 6731
IL32 6728
SOCS3 6669
ISG20 6656
PRTN3 6654
IL2RA 6652
IL23A 6621
FOS 6620
IFITM1 6615
S1PR1 6602
EGR1 6587
SMAD3 6553
INPPL1 6545
SYK 6538
SMARCA4 6535
OAS2 6533
IL2RB 6531
MEF2A 6500

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL19 6750
LTA 6732
LCK 6731
IL32 6728
SOCS3 6669
ISG20 6656
PRTN3 6654
IL2RA 6652
IL23A 6621
FOS 6620
IFITM1 6615
S1PR1 6602
EGR1 6587
SMAD3 6553
INPPL1 6545
SYK 6538
SMARCA4 6535
OAS2 6533
IL2RB 6531
MEF2A 6500
SH2B3 6476
PTPN1 6442
CDC42 6439
TRIM5 6436
PTPRJ 6425
IRF4 6371
CAPZA1 6364
IFIT5 6357
IL12RB1 6344
SLA2 6316
PIK3CD 6284
IRS1 6254
CISH 6227
LCP1 6221
SHC1 6208
NOD2 6204
SKP1 6201
SOS2 6197
IFNGR2 6161
HLA-F 6153
PIM1 6139
TNFRSF25 6137
CAMK2D 6135
TRAF2 6129
PTPN12 6123
MAPKAPK3 6059
FOXO1 6029
TNFSF14 6020
ABCE1 6012
PSME4 5997
IFNAR1 5949
PRKCD 5933
KPNA5 5908
RALA 5855
CNN2 5849
ITGB2 5848
GATA3 5837
PML 5799
FYN 5798
MTAP 5777
JUNB 5769
PDE12 5768
YWHAZ 5742
BCL2 5640
CBL 5629
RBX1 5617
STAT1 5616
RAPGEF1 5614
NKIRAS1 5599
STX3 5598
CSK 5596
CASP3 5595
POM121 5593
MAP3K14 5560
IRF9 5551
NUP85 5526
EDARADD 5515
PSMD3 5506
ADAR 5502
RORA 5488
MX2 5487
PTPN9 5460
PSMC5 5418
RAP1B 5399
HIF1A 5397
PPP2CB 5390
MAPK7 5377
DUSP4 5374
NFKBIA 5246
TNFRSF1B 5226
MAP2K7 5221
TYK2 5218
UBE2D2 5167
PSMB8 5160
PSMA2 5110
PSMA1 5104
ATF1 5042
PSMD13 4927
MAP2K6 4916
PSMB9 4898
AKT1 4880
SEC13 4873
TRIM14 4867
PSMB3 4780
HLA-E 4747
SEH1L 4691
NUP205 4686
IFI6 4664
PTPN6 4624
IRAK4 4586
NUP37 4573
PTK2B 4567
NUP43 4558
RPLP0 4527
EIF4A3 4502
FLT3LG 4475
CDKN1B 4449
PPP2CA 4425
HSP90AA1 4393
KPNA2 4362
PPIA 4348
IL15 4326
KPNB1 4322
PSMC6 4301
PSMD11 4285
OAS3 4274
FLNB 4260
HMGB1 4233
EIF4G2 4203
AIP 4195
PSMA3 4184
LTB 4178
ARIH1 4160
PSMA5 4135
CD44 4090
IFIT3 4084
MAP2K4 4063
PPM1B 4020
EIF4G1 4004
ZEB1 3975
POM121C 3938
TNFSF13B 3913
MAP2K1 3910
MX1 3882
TRIM26 3876
EIF4A1 3847
LMNB1 3817
TRIM8 3786
TRIM25 3781
STX4 3763
BIRC2 3690
ICAM1 3676
UBE2D3 3581
PPP2R1B 3568
IL10RA 3548
TP53 3539
PSMA7 3526
PSMD14 3518
NUP54 3515
NUP188 3510
PSMD2 3485
STAT4 3479
IFIT1 3470
RNF7 3420
UBE2M 3396
JUN 3366
TNFSF13 3354
PTPN4 3303
B2M 3286
ADAM17 3250
PSMD9 3215
IRF1 3171
EIF4E2 3157
SP100 3155
RPS6KA2 3112
TRIM35 3101
CASP1 3008
NUP50 2999
SQSTM1 2997
HNRNPF 2984
PSMD7 2963
TRIM2 2956
RAE1 2950
PIK3R1 2862
MIF 2857
BIRC5 2843
TRAF6 2839
DUSP3 2834
IL12A 2822
SOCS1 2817
INPP5D 2806
VRK3 2746
SOCS2 2725
PIK3R2 2723
P4HB 2641
NUP210 2605
BCL2L1 2559
PTPN18 2542
MAPKAPK2 2498
TGFB1 2486
SOD2 2479
NUP214 2474
PTPN11 2447
CHUK 2435
EIF4A2 2412
ISG15 2402
MYD88 2396
GSDMD 2381
PSME1 2379
AAAS 2354
PSME2 2344
PSMB6 2326
IRAK2 2293
STAT3 2282
TPR 2275
IKBKB 2240
CSF1 2222
TALDO1 2220
MAP3K8 2194
NUP98 2149
SH2B1 2147
GRAP2 2139
STAT6 2136
VAV1 2134
IL21R 2127
NUP153 2123
TCP1 2106
EIF4G3 2101
OAS1 2087
IFIT2 2077
RPS6KA5 2063
CRKL 2037
PLCG1 2017
BATF 1998
NUP62 1978
MAPK14 1942
IL1RAP 1938
KPNA3 1913
PSMD6 1908
IL27RA 1907
PIK3CA 1851
NOD1 1812
HSPA9 1744
TBK1 1627
IP6K2 1582
BIRC3 1578
DUSP7 1564
PSMC4 1563
UBA52 1530
BCL2L11 1506
STAT5B 1489
PSMD8 1397
IL4R 1380
FOXO3 1360
HNRNPA2B1 1320
TRIM45 1301
TRIM46 1291
SAMHD1 1288
PELI1 1263
IRF2 1258
PSMB1 1218
STX1A 1081
VIM 1021
IL6ST 1001
CLCF1 986
BCL6 943
NUP107 902
IFNAR2 885
KPNA4 868
HLA-C 848
EIF4E 798
NUP155 778
PSMD4 754
PIN1 714
UBA3 704
TRIM38 689
PSMC1 611
UBE2L6 603
SOD1 580
POU2F1 566
VAMP2 543
MAP3K3 495
CREB1 472
PSMD1 458
GRB2 448
TEC 441
CUL5 420
RPS27A 373
PAK2 359
IRF3 332
HLA-H 279
UBE2V1 236
PSMA6 230
JAK2 227
PSME3 210
GAB2 208
IFNGR1 186
TRAF3 169
KRAS 138
USP18 113
SLA 86
VEGFA 73
BRWD1 45
DDX58 44
PSMD12 20
UBB -13
APP -30
MAPK9 -75
IL17RA -142
MT2A -149
UBE2D1 -157
IL12RB2 -158
PSMB10 -165
IL17RC -205
TXLNA -224
SOCS5 -255
CFL1 -271
CCR1 -273
OSM -297
RELB -323
PITPNA -449
CEBPD -462
PSMB7 -481
AKT2 -487
MAP2K3 -511
CTF1 -589
HERC5 -594
NFKB2 -613
HLA-B -648
GSTO1 -666
TNFSF9 -669
PTPN23 -677
CDKN1A -682
ABL2 -712
PDCD4 -714
NKIRAS2 -820
CCND1 -822
CAMK2G -829
BST2 -858
OASL -940
PTPN7 -1013
NUP133 -1034
UBC -1067
PIK3R3 -1092
PSMB5 -1101
NUP160 -1133
MAPK1 -1146
TNF -1183
RELA -1231
STAT5A -1233
EIF2AK2 -1244
RANBP2 -1283
PRKACA -1287
UBE2E1 -1323
MAP3K7 -1330
BTRC -1346
NUP35 -1373
GRB10 -1415
IL17C -1451
MAPK3 -1492
TRIM21 -1550
IL18BP -1565
MUC1 -1704
PTPN13 -1751
PSMC3 -1757
IL10RB -1758
CD4 -1759
CRK -1792
TRIM68 -1808
SNRPA1 -1814
TNFRSF12A -1815
UBE2N -1821
CANX -1853
XAF1 -1865
TOLLIP -1966
TNFRSF1A -1997
STXBP2 -2011
PELI3 -2030
IL6R -2047
SUMO1 -2075
PPP2R5D -2111
HLA-A -2118
NUP93 -2168
PIAS1 -2220
NEDD4 -2232
IFI30 -2249
PTPN2 -2262
ALOX5 -2277
KPNA1 -2316
IL15RA -2342
UBA7 -2353
IL16 -2363
TNIP2 -2433
SIGIRR -2543
JAK1 -2617
PSMF1 -2618
IFI35 -2631
IRS2 -2652
IRF5 -2677
STAT2 -2692
IRF7 -2706
RPS6KA1 -2723
HRAS -2761
ARF1 -2822
YES1 -2840
IRAK3 -2884
LGALS9 -2932
TRIM62 -2973
CUL1 -2993
CXCL2 -3018
CSF3R -3067


Immune System

Immune System
405
set Immune System
setSize 1091
pANOVA 0.000415
s.dist 0.0654
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
IL19 6750
LTA 6732
LCK 6731
IL32 6728
CD3E 6720
CD53 6718
ZAP70 6707
GZMM 6698
AAMP 6691
SOCS3 6669
CHRNB4 6666
CD47 6665
ISG20 6656
PRTN3 6654
IL2RA 6652
CLEC2B 6650
FBXO10 6639
STIM1 6631
CD3D 6629
IL23A 6621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL19 6750
LTA 6732
LCK 6731
IL32 6728
CD3E 6720
CD53 6718
ZAP70 6707
GZMM 6698
AAMP 6691
SOCS3 6669
CHRNB4 6666
CD47 6665
ISG20 6656
PRTN3 6654
IL2RA 6652
CLEC2B 6650
FBXO10 6639
STIM1 6631
CD3D 6629
IL23A 6621
FOS 6620
FBXO11 6618
IFITM1 6615
NFATC1 6606
S1PR1 6602
POLR3G 6601
RNF220 6598
CARD9 6596
EGR1 6587
SPTAN1 6573
TBC1D10C 6561
TLR9 6559
SMAD3 6553
INPPL1 6545
DNM1 6542
SYK 6538
SMARCA4 6535
OAS2 6533
IL2RB 6531
PTK2 6515
UBE2R2 6510
MEF2A 6500
FBXW7 6497
SURF4 6490
DEGS1 6484
SH2B3 6476
FBXL22 6469
CD96 6463
PTPN1 6442
CDC42 6439
TRIM5 6436
ARL8A 6432
PRKCSH 6429
PTPRJ 6425
NLRC5 6422
ENPP4 6404
SMURF1 6399
HMHA1 6391
RNF213 6377
IRF4 6371
CAPZA1 6364
IFIT5 6357
PNP 6347
IL12RB1 6344
BTN3A2 6326
SLA2 6316
CPNE1 6299
UBE2F 6294
PIK3CD 6284
MAPKAP1 6279
S100A11 6273
IRS1 6254
PPP3R1 6252
RNF115 6245
BTN3A3 6232
ACTR1A 6228
CISH 6227
MMP25 6224
LCP1 6221
ACTG1 6212
SHC1 6208
NOD2 6204
SKP1 6201
TRIM56 6199
SOS2 6197
RAP1A 6166
DYNLT1 6165
RNF111 6162
IFNGR2 6161
TUBB 6157
HLA-F 6153
TRIM41 6152
NHLRC3 6151
LRSAM1 6141
ARHGAP9 6140
PIM1 6139
TNFRSF25 6137
CAMK2D 6135
TRAF2 6129
CCT8 6126
PTPN12 6123
CPPED1 6118
ACTR3 6108
WIPF1 6063
MAPKAPK3 6059
RNASET2 6050
FOXO1 6029
CNPY3 6023
TNFSF14 6020
ABCE1 6012
RAB14 6011
VAMP8 6006
PSME4 5997
ATG12 5966
IFNAR1 5949
KIF5B 5935
PRKCD 5933
KIF3B 5925
RASGRP2 5924
PDAP1 5921
KPNA5 5908
RNF125 5897
ATOX1 5890
NME2 5881
RNF19A 5874
IFIH1 5861
RALA 5855
CNN2 5849
ITGB2 5848
GATA3 5837
TNFAIP3 5836
PA2G4 5834
PML 5799
FYN 5798
PILRB 5797
CD274 5796
TXK 5787
MTAP 5777
JUNB 5769
PDE12 5768
YWHAZ 5742
IMPDH2 5708
PRDX6 5689
COPB1 5676
BIN2 5670
MANBA 5647
MEX3C 5642
BCL2 5640
CBL 5629
PRKCB 5627
UBE2J1 5621
RBX1 5617
STAT1 5616
RAPGEF1 5614
NKIRAS1 5599
STX3 5598
CSK 5596
CASP3 5595
POM121 5593
POLR1D 5587
TOM1 5571
DCTN3 5566
MAP3K14 5560
IRF9 5551
NUP85 5526
KBTBD8 5518
EDARADD 5515
PSMD3 5506
ADAR 5502
GHDC 5494
UBR2 5489
RORA 5488
MX2 5487
HSPA1B 5474
PTPN9 5460
PARK2 5459
UBA5 5432
KLHL25 5423
PSMC5 5418
BTBD1 5401
RAP1B 5399
RAB27A 5398
HIF1A 5397
PPP2CB 5390
MAPK7 5377
DUSP4 5374
KLHL5 5368
CARD11 5340
FBXL3 5338
IKBKE 5255
CMTM6 5253
ANAPC2 5252
NFKBIA 5246
TNFRSF1B 5226
AHCYL1 5224
MAP2K7 5221
TYK2 5218
PSAP 5217
ACTR10 5211
CAB39 5203
SEC23A 5194
FBXO21 5189
SIAH2 5168
UBE2D2 5167
FBXL14 5163
PSMB8 5160
FBXW4 5157
KIF18A 5152
ACLY 5144
SNAP23 5142
RNF126 5140
TMEM179B 5135
PAG1 5129
PSMA2 5110
ATP6V0E1 5107
PSMA1 5104
PYGB 5094
RAB6A 5063
POLR2H 5045
ATF1 5042
PGM2 5031
DYNC1H1 5029
UBE2K 4999
CYLD 4997
RAB5C 4994
HGSNAT 4992
CAND1 4969
LRRFIP1 4960
ALDOA 4959
LTA4H 4946
CASP8 4940
ROCK1 4937
KCTD7 4929
PSMD13 4927
MAP2K6 4916
RICTOR 4901
PSMB9 4898
AP1B1 4886
AP2A1 4882
AKT1 4880
FBXO30 4877
SEC13 4873
TRIM14 4867
TXNIP 4854
DYNLL2 4788
PSMB3 4780
RILP 4777
NF2 4776
ACTB 4760
HLA-E 4747
VAT1 4736
UBE3A 4728
ITGAL 4725
IDH1 4706
ANAPC4 4698
SEH1L 4691
NUP205 4686
TLR3 4677
FTH1 4665
IFI6 4664
KIF2C 4652
CUL2 4648
STOM 4641
ASAH1 4629
YPEL5 4627
PTPN6 4624
TMBIM1 4623
WASF1 4614
DYNLL1 4607
POLR3F 4603
IRAK4 4586
EP300 4582
FZR1 4578
NUP37 4573
ATP6V1A 4569
PTK2B 4567
ANAPC1 4561
NUP43 4558
RPLP0 4527
ATP6V1C1 4518
EIF4A3 4502
FBXL12 4494
KLC1 4487
WSB1 4486
YWHAB 4484
FLT3LG 4475
CDKN1B 4449
VAV2 4443
FBXO9 4440
MYH9 4430
SVIP 4426
PPP2CA 4425
HSP90AA1 4393
ADAM10 4387
CD55 4376
RHOA 4371
MAP3K1 4364
KPNA2 4362
PPIA 4348
IL15 4326
KPNB1 4322
PSMC6 4301
POLR3E 4300
PSMD11 4285
OAS3 4274
FLNB 4260
CYB5R3 4246
MALT1 4240
HMGB1 4233
LNPEP 4223
ABI1 4216
EIF4G2 4203
AIP 4195
PCBP2 4187
PSMA3 4184
LTB 4178
MYO9B 4169
ARIH1 4160
ARPC3 4159
DNAJC3 4154
NDUFC2 4149
UNC93B1 4145
PSMA5 4135
IQGAP1 4122
BCL10 4113
TICAM1 4102
CD44 4090
IFIT3 4084
MAP2K4 4063
ATP6V0B 4033
PPM1B 4020
KLHL20 4010
EIF4G1 4004
ASB7 3983
ZEB1 3975
POM121C 3938
KLHL2 3937
TNFSF13B 3913
MAP2K1 3910
PRCP 3909
NEDD4L 3893
FBXO31 3885
MX1 3882
C6orf120 3881
ICAM5 3879
TRIM26 3876
EIF4A1 3847
POLR3GL 3840
KCMF1 3839
ITGAV 3832
ZNRF2 3831
LMNB1 3817
RASGRP1 3802
PDPK1 3800
TRIM8 3786
POLR3H 3782
TRIM25 3781
STX4 3763
VASP 3762
ICAM3 3754
UBE2G2 3744
ICAM2 3724
SUGT1 3713
ATP6V0A2 3712
BIRC2 3690
CD247 3677
ICAM1 3676
ACTR1B 3675
KIF11 3664
PPP3CA 3660
NBEAL2 3651
SEC61A1 3623
RAB10 3622
AP1G1 3619
ZBTB16 3616
VAPA 3614
CAPZA2 3606
PGAM1 3596
NCKAP1L 3594
SDCBP 3588
UBE2D3 3581
TRIM37 3574
RHOG 3573
PPP2R1B 3568
UBE3B 3559
IL10RA 3548
TP53 3539
NFATC3 3532
PSMA7 3526
RNF138 3523
PSMD14 3518
NUP54 3515
NUP188 3510
GM2A 3504
PTEN 3496
PSMD2 3485
B4GALT1 3483
STAT4 3479
KBTBD7 3477
CUL3 3475
IFIT1 3470
CD63 3465
UBA6 3437
PSEN1 3425
RNF7 3420
KLHL21 3397
UBE2M 3396
PANX1 3389
RAB4B 3386
ORMDL3 3383
CASP4 3371
LPCAT1 3370
ATP6V0D1 3369
JUN 3366
TNFSF13 3354
RAF1 3347
SAR1B 3324
APRT 3317
ASB8 3309
PTPN4 3303
TIRAP 3298
B2M 3286
CDK13 3275
ADAM17 3250
ITPR1 3245
DSN1 3232
DCTN5 3216
PSMD9 3215
RASGRP3 3213
TAP2 3212
CD74 3208
ABI2 3199
DHX9 3182
TAPBP 3176
IRF1 3171
EIF4E2 3157
CYBA 3156
SP100 3155
PPP2R5C 3153
ANO6 3139
SLC2A3 3128
NPC2 3117
RPS6KA2 3112
CSNK2B 3108
TRIM35 3101
HEBP2 3080
UBE2V2 3079
LCP2 3074
FBXW2 3068
TMEM30A 3061
ADAM8 3045
EVL 3039
CASP1 3008
PDIA3 3007
NEU1 3004
NUP50 2999
SQSTM1 2997
MKRN1 2985
HNRNPF 2984
MICB 2971
KLC4 2968
PSMD7 2963
TRIM2 2956
RAE1 2950
POLR3C 2940
RHOF 2935
HERC3 2932
ATAD3B 2926
UBE2O 2879
NFKBIE 2877
SIKE1 2867
PIK3R1 2862
MIF 2857
BIRC5 2843
TRAF6 2839
DUSP3 2834
IL12A 2822
SOCS1 2817
INPP5D 2806
PPP3CB 2798
UBAC1 2786
TRIM11 2781
VRK3 2746
GLB1 2743
RBBP6 2734
SOCS2 2725
PIK3R2 2723
FBXL5 2716
GMFG 2707
ELMO2 2699
WIPF2 2698
SARM1 2682
AGL 2667
TRIM4 2658
PLAC8 2655
SEC24B 2647
P4HB 2641
FBXL4 2638
RNF6 2636
SLC15A4 2634
HMOX2 2624
KLHL11 2621
RNF216 2617
TAP1 2607
NUP210 2605
CAP1 2598
STUB1 2581
BCL2L1 2559
RNF34 2543
PTPN18 2542
ATP6V1F 2531
DBNL 2529
PJA2 2526
MAPKAPK2 2498
POLR2F 2490
RNF19B 2488
TGFB1 2486
PIK3R4 2484
PAFAH1B2 2481
SOD2 2479
SNAP29 2477
NUP214 2474
PTPN22 2454
PTPN11 2447
BTN3A1 2444
ERAP1 2441
DYNC1I2 2439
CHUK 2435
SEC24A 2422
EIF4A2 2412
ISG15 2402
MYD88 2396
GSDMD 2381
PSME1 2379
AAAS 2354
PRKACB 2348
PSME2 2344
ELMO1 2329
PSMB6 2326
ANAPC7 2305
HERC1 2295
IRAK2 2293
STAT3 2282
WASF2 2278
TPR 2275
SEC31A 2273
RAB5B 2269
IKBKB 2240
GOLGA7 2236
CBLB 2223
CSF1 2222
TALDO1 2220
EEF1A1 2202
MAP3K8 2194
ORAI1 2193
PDXK 2171
GNS 2168
CD46 2156
NUP98 2149
SH2B1 2147
KIF23 2145
GRAP2 2139
STAT6 2136
VAV1 2134
IL21R 2127
PLA2G6 2126
NUP153 2123
PRKCQ 2116
TCP1 2106
EIF4G3 2101
OAS1 2087
IFIT2 2077
DYNC1LI1 2070
PRKCE 2068
RPS6KA5 2063
ARPC5 2062
CRKL 2037
GYG1 2019
PLCG1 2017
ARIH2 2005
IGF2R 1999
BATF 1998
C8G 1992
SLC11A1 1991
CPNE3 1990
NUP62 1978
AP1S3 1965
TAX1BP1 1953
RNF4 1945
MAPK14 1942
IL1RAP 1938
ILF2 1932
APEH 1926
KPNA3 1913
COTL1 1912
DERA 1911
PSMD6 1908
IL27RA 1907
UBE2Z 1890
ORAI2 1888
UBE2Q1 1884
MLST8 1877
PIK3CA 1851
FBXL18 1835
RNF114 1817
NOD1 1812
ITPR3 1806
RACGAP1 1790
FABP5 1782
SEC61G 1774
HSPA9 1744
GLIPR1 1708
RAC1 1706
ICOSLG 1689
REL 1674
DCTN6 1667
EEA1 1659
UBE2G1 1642
POLR2E 1641
TBK1 1627
ARPC2 1609
ITGA4 1601
PTGES2 1595
ACTR2 1587
IP6K2 1582
TPP2 1579
BIRC3 1578
VHL 1575
DUSP7 1564
PSMC4 1563
SPSB1 1558
TMC6 1553
ATP8A1 1544
PPP2R5A 1532
UBA52 1530
AIM2 1528
BCL2L11 1506
NCK1 1491
STAT5B 1489
VPRBP 1485
CCT2 1476
STK11IP 1471
UBE2Q2 1458
WWP1 1455
DHX36 1406
RAP2B 1405
PSMD8 1397
IL4R 1380
UBE2B 1366
TXN 1364
FOXO3 1360
DTX4 1346
UBE2H 1339
AGA 1330
THOP1 1328
XRCC5 1324
HNRNPA2B1 1320
DIAPH1 1310
TRIM45 1301
TRIM46 1291
SAMHD1 1288
RIPK3 1273
KIF2A 1265
PELI1 1263
IRF2 1258
RAC2 1253
CLTA 1224
PSMB1 1218
VCL 1214
CDC34 1212
RNF14 1203
TSPAN14 1194
RAB24 1173
MUC12 1150
SCAMP1 1119
ZNRF1 1117
ANAPC5 1095
TMEM63A 1088
STX1A 1081
PPP2R5B 1078
ANAPC13 1063
FAF2 1049
QSOX1 1045
TRIM36 1037
HVCN1 1026
VIM 1021
IL6ST 1001
DNM2 1000
COMMD9 996
CLCF1 986
MUC5B 977
ARSA 975
PLCG2 955
BCL6 943
DDX41 928
NUP107 902
CENPE 899
CALR 898
RAB18 897
IFNAR2 885
KPNA4 868
PPP2R5E 863
MYLIP 854
HLA-C 848
TIFA 840
HSPA1A 832
HERC4 825
ITPR2 824
FBXO22 804
EIF4E 798
TLR1 782
NUP155 778
MICA 772
DAPP1 769
EEF2 765
ATP6V1G2 763
PSMD4 754
FBXL8 736
CRCP 723
PIN1 714
UBA3 704
TRIM38 689
SRP14 652
NCSTN 631
ATP6V1E1 613
PSMC1 611
UBE2L6 603
ANAPC11 601
FBXW8 600
CD81 597
SOD1 580
CAT 573
POU2F1 566
VAMP2 543
FBXO32 540
MAP3K3 495
LGMN 492
CREB1 472
HCST 469
SLC27A2 463
CAPN1 461
PSMD1 458
GRB2 448
TEC 441
CUL5 420
RCHY1 419
ITCH 392
RPS27A 373
TRAIP 362
PAK2 359
CYFIP2 345
IRF3 332
NFATC2 319
DCTN4 312
KIF3A 285
HLA-H 279
DGAT1 276
CASP9 264
TLR5 256
UBE2V1 236
PSMA6 230
JAK2 227
TANK 214
MTOR 213
PSME3 210
GAB2 208
IFNGR1 186
TRAF7 181
TRIM39 180
HECTD1 171
TRAF3 169
ALAD 163
ECSIT 140
KRAS 138
USP18 113
SLA 86
CDC23 84
VEGFA 73
FBXO7 69
HEXB 66
ERP44 50
BRWD1 45
DDX58 44
PSMD12 20
FBXO4 17
BAIAP2 5
UBE2L3 -11
MAVS -12
UBB -13
ASB6 -18
FKBP1A -26
APP -30
PTPRN2 -41
CUL7 -70
RNF41 -74
MAPK9 -75
WASL -113
IL17RA -142
MT2A -149
UBE2D1 -157
IL12RB2 -158
PSMB10 -165
POLR3A -171
CTSC -185
ARSB -190
IL17RC -205
AMPD3 -213
TXLNA -224
SOCS5 -255
PIK3AP1 -261
FBXL15 -268
CFL1 -271
CCR1 -273
OSM -297
UBE3C -304
SLC44A2 -306
PPIE -319
NLRX1 -320
RELB -323
TRPC1 -327
XRCC6 -338
CTSO -350
KEAP1 -357
BTBD6 -359
ANAPC10 -361
MLEC -366
PSTPIP1 -368
TRAPPC1 -374
RBCK1 -381
ATP6V1H -409
DHX58 -423
SRC -427
PITPNA -449
DYNC1LI2 -456
ARPC1B -458
CEBPD -462
PSMB7 -481
AKT2 -487
CDC20 -491
UBR1 -499
MAP2K3 -511
ABL1 -538
GRN -545
TRIM9 -551
BTN2A2 -555
CTF1 -589
CTNNB1 -591
HERC5 -594
POLR2K -599
SIPA1 -606
AP2M1 -611
NFKB2 -613
GCA -626
HLA-B -648
GSTO1 -666
TNFSF9 -669
PTPN23 -677
CDKN1A -682
HECTD3 -683
POLR3D -696
CALM1 -703
ABL2 -712
PDCD4 -714
DNAJC13 -715
SEC24C -725
SKP2 -743
FBXL20 -749
PLEKHO2 -763
PLD3 -789
NCKIPSD -806
RAB7A -809
KIFAP3 -814
NKIRAS2 -820
ACAA1 -821
CCND1 -822
CAMK2G -829
MAN2B1 -836
KIF15 -844
UBE2W -855
BST2 -858
LONRF1 -865
IQGAP2 -884
VCP -905
OASL -940
PGM1 -953
ATP11A -955
ATG5 -962
PTPN7 -1013
MVP -1017
NUP133 -1034
UBC -1067
TRIB3 -1072
PIK3R3 -1092
PSMB5 -1101
ASB1 -1106
DZIP3 -1113
FBXO6 -1115
GUSB -1130
NUP160 -1133
ATP6V1B2 -1144
MAPK1 -1146
C3AR1 -1150
POLR3K -1155
NIT2 -1163
GAN -1181
TNF -1183
KBTBD6 -1184
RAP1GAP2 -1226
RELA -1231
STAT5A -1233
LAMP1 -1238
LRRC41 -1240
EIF2AK2 -1244
FGR -1246
PLAUR -1249
HACE1 -1274
RANBP2 -1283
PRKACA -1287
UBOX5 -1296
POLR1C -1305
UBE2E1 -1323
MAP3K7 -1330
KLC2 -1333
CD58 -1341
BTRC -1346
UBE2E3 -1348
NUP35 -1373
GRB10 -1415
APAF1 -1418
IL17C -1451
FTL -1460
AP1M1 -1490
MAPK3 -1492
TRIM21 -1550
CTSB -1552
KLHL22 -1558
IL18BP -1565
CD59 -1570
FBXO15 -1612
DET1 -1644
GAA -1649
BLMH -1651
HSP90AB1 -1669
CAPZB -1687
UBE2C -1688
MUC1 -1704
GPI -1707
CEACAM1 -1731
SERPINB1 -1747
TRIP12 -1748
PTPN13 -1751
PSMC3 -1757
IL10RB -1758
CD4 -1759
GGH -1762
CRK -1792
ATP6V0A1 -1794
TRIM68 -1808
SNRPA1 -1814
TNFRSF12A -1815
UBE2N -1821
KCTD6 -1828
NLRP1 -1836
RNF25 -1848
CANX -1853
XAF1 -1865
PAK1 -1898
IMPDH1 -1918
GDI2 -1929
FUCA2 -1943
BTN2A1 -1946
RAB37 -1952
THEM4 -1958
TOLLIP -1966
CTSA -1969
STK10 -1974
UBE2J2 -1981
TNFRSF1A -1997
STXBP2 -2011
SLCO4C1 -2015
PELI3 -2030
BRI3 -2046
IL6R -2047
PRR5 -2054
SUMO1 -2075
SEC61A2 -2097
CASP10 -2102
TCIRG1 -2103
PPP2R5D -2111
HLA-A -2118
LIMK1 -2125
CSTB -2133
KIF3C -2140
TLR2 -2161
NUP93 -2168
SERPINB6 -2181
ARMC8 -2213
KCNAB2 -2218
PIAS1 -2220
QPCT -2228
LAIR1 -2231
NEDD4 -2232
CYFIP1 -2237
GALNS -2239
IFI30 -2249
PTPN2 -2262
ALOX5 -2277
SIAH1 -2294
KIF22 -2299
KPNA1 -2316
ATG7 -2339
IL15RA -2342
PLAU -2343
UBE2E2 -2345
UBA7 -2353
IL16 -2363
CDC16 -2388
RNF135 -2391
ASB13 -2394
LAT2 -2395
FADD -2425
CCNF -2430
TNIP2 -2433
RAB3A -2441
AP2S1 -2469
RNF144B -2481
DPP7 -2486
GSTP1 -2505
CREG1 -2512
ATP11B -2514
CREBBP -2526
TREX1 -2536
SIGIRR -2543
DCTN2 -2552
SEC24D -2554
ERAP2 -2561
ITGB7 -2567
JAK1 -2617
PSMF1 -2618
ATP8B4 -2621
FUCA1 -2630
IFI35 -2631
PLD1 -2643
IRS2 -2652
A1BG -2674
IRF5 -2677
MGRN1 -2681
STAT2 -2692
IRF7 -2706
RPS6KA1 -2723
SMURF2 -2739
HRAS -2761
CKAP4 -2767
UNKL -2783
CD79B -2819
ARF1 -2822
ATP6V0C -2828
STBD1 -2832
UNC13D -2833
YES1 -2840
FBXL19 -2861
VAMP3 -2871
PYCARD -2882
IRAK3 -2884
RAB3D -2893
DNAJC5 -2896
FBXL16 -2899
MRC2 -2902
ITK -2929
LGALS9 -2932
TRPM2 -2952
ALDOC -2957
CD300A -2967
TRIM62 -2973
HLA-DMA -2987
NOS3 -2991
CUL1 -2993
ATP6V0E2 -2997
ASB2 -3002
TYROBP -3005
CXCL2 -3018
PFKL -3020
TXNDC5 -3031
TREML2 -3039
NLRP3 -3052
P2RX1 -3063
CSF3R -3067
CTSZ -3081
S100P -3087
NCF4 -3102
MPO -3113


Infectious disease

Infectious disease
411
set Infectious disease
setSize 507
pANOVA 0.000465
s.dist 0.0921
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
LCK 6731
ST6GALNAC3 6703
PARP10 6688
PARP8 6633
S1PR1 6602
TLR9 6559
HDAC3 6558
SYK 6538
PTK2 6515
PTGER4 6493
KDM1A 6473
RCC1 6472
CHMP1A 6467
PHF21A 6450
CDK9 6449
CDC42 6439
PRKCSH 6429
GNG12 6415
RNF213 6377
CORO1A 6323

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LCK 6731
ST6GALNAC3 6703
PARP10 6688
PARP8 6633
S1PR1 6602
TLR9 6559
HDAC3 6558
SYK 6538
PTK2 6515
PTGER4 6493
KDM1A 6473
RCC1 6472
CHMP1A 6467
PHF21A 6450
CDK9 6449
CDC42 6439
PRKCSH 6429
GNG12 6415
RNF213 6377
CORO1A 6323
PTGES3 6314
IRS1 6254
GSK3A 6226
ACTG1 6212
SKP1 6201
ENTPD5 6180
IFNGR2 6161
TUBB 6157
ACTR3 6108
UVRAG 6091
WIPF1 6063
NOXA1 6046
RPS11 6042
ATP1B3 6036
PSME4 5997
UBAP1 5979
GTF2A2 5974
ST3GAL3 5961
IFNAR1 5949
VPS25 5942
GRSF1 5934
XRCC4 5923
KPNA5 5908
RPL8 5868
PARP4 5852
MNAT1 5844
CCNH 5835
DDX5 5815
PML 5799
FYN 5798
RPL36AL 5773
RPL31 5771
CHD3 5715
VPS33B 5714
IMPDH2 5708
RPL39L 5706
ADRB2 5703
CBL 5629
RPS15A 5624
RBX1 5617
POM121 5593
MAN2A1 5584
SLC25A4 5557
NUP85 5526
FZD7 5524
PSMD3 5506
ST3GAL1 5472
RPL10A 5455
EZH2 5422
PSMC5 5418
RPL14 5360
HGS 5344
GTF2B 5342
GATAD2A 5332
CBX1 5330
UBE2I 5265
MOGS 5254
AHCYL1 5224
MAP2K7 5221
TYK2 5218
GSK3B 5172
CRBN 5169
PSMB8 5160
MAP2K2 5123
PSMA2 5110
PSMA1 5104
MBD3 5082
CCNT1 5074
TAF9 5067
RPS27L 5057
POLR2H 5045
DYNC1H1 5029
EDEM2 5003
NR3C1 5002
RCOR1 4991
RPL29 4990
RPL7 4967
PARP9 4948
ROCK1 4937
XPO1 4933
MGAT2 4928
PSMD13 4927
MAP2K6 4916
PRKAR1A 4900
SUDS3 4899
PSMB9 4898
AP1B1 4886
AP2A1 4882
SEC13 4873
TXNIP 4854
DUT 4849
DYNLL2 4788
PSMB3 4780
ACTB 4760
RPN1 4758
FAU 4740
PDCD6IP 4715
TAF10 4705
PARP6 4693
SEH1L 4691
NUP205 4686
CHMP7 4685
HMGA1 4669
RPL13 4655
TAF11 4644
PARP14 4616
WASF1 4614
DYNLL1 4607
EED 4593
NUP37 4573
NUP43 4558
VPS36 4535
RPLP0 4527
MGAT4A 4472
VAV2 4443
MYH9 4430
HSP90AA1 4393
KPNA2 4362
PPIA 4348
VPS37A 4337
KPNB1 4322
GNG2 4308
PSMC6 4301
PSMD11 4285
RPS29 4263
TAF5 4237
GNB2 4217
ABI1 4216
PSMA3 4184
MYO9B 4169
ARPC3 4159
DNAJC3 4154
TRIM27 4151
PSMA5 4135
GATAD2B 4125
RPL41 4115
STT3A 4108
GPS2 4092
MAP2K4 4063
TBL1XR1 4052
LHB 4042
RPS5 4030
LIG4 4025
PACS1 3988
POM121C 3938
NMT1 3919
MAP2K1 3910
RPS10 3900
NEDD4L 3893
RPS26 3830
RPL11 3810
RPS3A 3771
CHMP2A 3751
SUGT1 3713
RPL4 3711
GNG5 3683
CD247 3677
POLR2G 3633
GTF2H4 3621
AP1G1 3619
DAXX 3610
MGAT1 3602
CPSF4 3597
SAP30 3595
NCKAP1L 3594
CHMP4A 3557
PSMA7 3526
TAF6 3521
REST 3519
PSMD14 3518
RPS9 3516
NUP54 3515
NUP188 3510
PSMD2 3485
TCEA1 3422
PARP16 3416
VAMP1 3373
JUN 3366
RPL3 3364
POLR2A 3361
B2M 3286
ADAM17 3250
ITPR1 3245
MTA2 3226
PSMD9 3215
ABI2 3199
RNGTT 3170
RPL23 3169
CYBA 3156
DAD1 3143
PLK2 3140
BRMS1 3097
TSG101 3096
SNF8 3081
VIPR1 3013
CASP1 3008
ATP1A3 3006
NUP50 2999
GTF2E2 2983
NCBP2 2973
PSMD7 2963
RAE1 2950
RPL36 2924
ATP1B1 2919
SUPT5H 2917
GNB5 2913
DBP 2883
PSIP1 2837
RPS12 2813
RPS7 2759
GTF2F2 2754
HDAC1 2753
SIGMAR1 2732
ELMO2 2699
WIPF2 2698
FUT8 2692
MAP1LC3B 2686
DVL1 2680
VTA1 2665
RPLP2 2663
POLR2C 2661
GNG4 2653
RPL37 2639
RPL35 2622
NUP210 2605
ADCY9 2546
PABPN1 2534
GTF2H5 2512
POLR2F 2490
TGFB1 2486
PIK3R4 2484
RB1 2475
NUP214 2474
RPL32 2458
NCBP1 2448
DYNC1I2 2439
RPS15 2414
ISG15 2402
SAP18 2391
GSDMD 2381
PSME1 2379
RPS28 2374
AAAS 2354
PRKACB 2348
PSME2 2344
VPS4A 2335
ELMO1 2329
PSMB6 2326
GIPR 2302
HNRNPK 2280
WASF2 2278
TPR 2275
TAF12 2247
RPS3 2229
ST6GAL1 2215
TAF13 2205
RPS6 2203
FKBP4 2181
RPS23 2178
NUP98 2149
VAV1 2134
NUP153 2123
DYNC1LI1 2070
ARPC5 2062
CHD4 2045
PLCG1 2017
NUP62 1978
AP1S3 1965
CDK7 1957
MAPK14 1942
BANF1 1929
KPNA3 1913
PSMD6 1908
RPL6 1906
P2RX4 1886
ITPR3 1806
RPL22 1781
SUPT16H 1773
RPL18 1752
RAC1 1706
STAM 1679
SAP30L 1664
RPS19 1660
POLR2E 1641
TBK1 1627
RPS16 1615
GANAB 1614
ARPC2 1609
ITGA4 1601
ACTR2 1587
VHL 1575
PSMC4 1563
FEN1 1554
RPL34 1552
UBA52 1530
RPL27A 1519
NCK1 1491
PSMD8 1397
TXN 1364
RAB5A 1345
RPL26 1337
GNAI2 1325
XRCC5 1324
POLR2B 1297
RPL28 1296
POLR2D 1251
CLTA 1224
ADORA2A 1219
PSMB1 1218
RPL37A 1174
CHMP2B 1172
STAM2 1112
STX1A 1081
GNAI3 1076
POLR2I 1067
PLCG2 955
HDAC2 944
NUP107 902
CALR 898
IFNAR2 885
KPNA4 868
HSPA1A 832
ITPR2 824
NA 823
NUP155 778
EEF2 765
PSMD4 754
RPL26L1 666
CHMP6 638
PSMC1 611
TAF4B 596
VAMP2 543
SH3GL1 514
ATP1A1 481
CREB1 472
ENO1 468
PSMD1 458
GRB2 448
CUL5 420
RPS25 393
RPSA 374
RPS27A 373
PAK2 359
GNB4 355
CYFIP2 345
HMG20B 327
MTA3 320
BRD4 308
RBBP4 290
RNMT 258
ST3GAL2 235
PSMA6 230
JAK2 227
PSME3 210
IFNGR1 186
VPS28 148
RPS24 131
ERCC3 128
PARP1 81
VEGFA 73
PSMD12 20
BAIAP2 5
TAF3 -1
UBB -13
FKBP1A -26
ELL -98
RPS18 -105
WASL -113
RPS20 -114
TAF2 -129
RHBDF2 -153
PSMB10 -165
RANGAP1 -174
ST6GALNAC4 -193
BECN1 -198
MGAT5 -200
GPR176 -280
TRIM28 -318
XRCC6 -338
PSTPIP1 -368
ATP6V1H -409
SRC -427
DYNC1LI2 -456
ARPC1B -458
CEBPD -462
RPL17 -480
PSMB7 -481
MAP2K3 -511
TXNRD1 -513
ABL1 -538
DVL2 -574
CTNNB1 -591
RANBP1 -597
POLR2K -599
GTF2F1 -601
AP2M1 -611
NFKB2 -613
RPL38 -629
TAF7 -687
CALM1 -703
SSRP1 -736
RPN2 -773
NCKIPSD -806
RAB7A -809
CHMP4B -830
TAF15 -892
VCP -905
HRH2 -914
DUSP16 -920
NUP133 -1034
UBC -1067
PSMB5 -1101
NUP160 -1133
MAPK1 -1146
C3AR1 -1150
RAN -1174
LIG1 -1221
RELA -1231
NCOR1 -1234
EIF2AK2 -1244
FGR -1246
RANBP2 -1283
PRKACA -1287
BTRC -1346
CTDP1 -1352
NUP35 -1373
ADM -1438
GTF2A1 -1445
IPO5 -1482
AP1M1 -1490
VPS37C -1491
MAPK3 -1492
SFPQ -1506
ST3GAL4 -1527
RPL9 -1663
HSP90AB1 -1669
GNAS -1685
RPL23A -1715
SUPT4H1 -1739
PSMC3 -1757
CD4 -1759
CRK -1792
CXCR4 -1826
CANX -1853
NMT2 -1891
IMPDH1 -1918
ADCY4 -1935
COMT -1986
VPS37B -1995
IL6R -2047
SUMO1 -2075
ERCC2 -2080
HLA-A -2118
ENTPD1 -2157
TLR2 -2161
NUP93 -2168
EPS15 -2175
RPLP1 -2185
GTF2H3 -2196
CYFIP1 -2237
KPNA1 -2316
MAN1B1 -2337
RPL15 -2423
CTNND1 -2446
AP2S1 -2469
GGT1 -2492
TAF4 -2511
PRKAR2A -2557
MGAT4B -2560
GNB1 -2592
DVL3 -2597
JAK1 -2617
PSMF1 -2618
PTGER2 -2682
STAT2 -2692
HBEGF -2695
NCOR2 -2696
ARF1 -2822
FURIN -2837
YES1 -2840
PYCARD -2882
DPEP2 -2945
RPS8 -2966
ADCY7 -2990
PRKAR1B -3015
STX1B -3043
NLRP3 -3052


M Phase

M Phase
483
set M Phase
setSize 272
pANOVA 0.00114
s.dist 0.115
p.adjustANOVA 0.129



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBGCP3 6638
TUBGCP6 6580
NEDD1 6562
TUBA4B 6556
CEP76 6523
RCC1 6472
TAOK1 6421
PDS5A 6341
CCNB1 6272
ACTR1A 6228
TUBB 6157
USO1 6098
PSME4 5997
LBR 5971
NCAPG2 5943
AURKB 5907
PAFAH1B1 5904
NCAPD3 5898
SIRT2 5840
INCENP 5832

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBGCP3 6638
TUBGCP6 6580
NEDD1 6562
TUBA4B 6556
CEP76 6523
RCC1 6472
TAOK1 6421
PDS5A 6341
CCNB1 6272
ACTR1A 6228
TUBB 6157
USO1 6098
PSME4 5997
LBR 5971
NCAPG2 5943
AURKB 5907
PAFAH1B1 5904
NCAPD3 5898
SIRT2 5840
INCENP 5832
STAG1 5829
NDEL1 5672
RAB1A 5660
PRKCB 5627
CENPJ 5613
POM121 5593
DCTN3 5566
NUP85 5526
PSMD3 5506
PSMC5 5418
TNPO1 5407
PPP2CB 5390
ODF2 5376
CENPF 5351
UBE2I 5265
ANAPC2 5252
NCAPD2 5235
PSMB8 5160
KIF18A 5152
PSMA2 5110
PSMA1 5104
NUDC 5046
DYNC1H1 5029
LEMD2 5022
CEP78 5013
VRK1 4985
XPO1 4933
PSMD13 4927
SDCCAG8 4907
PSMB9 4898
CEP250 4881
SEC13 4873
NEK7 4859
DYNLL2 4788
PSMB3 4780
NEK9 4727
CKAP5 4720
PDS5B 4713
ANAPC4 4698
SEH1L 4691
NUP205 4686
CHMP7 4685
CCNB2 4682
HAUS8 4673
PMF1 4661
LPIN2 4654
KIF2C 4652
RAB2A 4608
DYNLL1 4607
NUP37 4573
ANAPC1 4561
NUP43 4558
NSL1 4556
SPAST 4541
CENPA 4463
PPP2CA 4425
SMC3 4416
MAD1L1 4397
HSP90AA1 4393
KPNB1 4322
PSMC6 4301
PSMD11 4285
CEP63 4259
CC2D1B 4256
PCM1 4253
SMC4 4224
CENPP 4188
PSMA3 4184
LPIN1 4157
NIPBL 4140
PSMA5 4135
NDC80 4054
BLZF1 4015
TUBA1C 3980
PRKCA 3971
POM121C 3938
MIS12 3865
AKAP9 3852
LMNB1 3817
B9D2 3803
CHMP2A 3751
CEP70 3663
PPP2R1B 3568
CHMP4A 3557
YWHAG 3556
PSMA7 3526
PSMD14 3518
NUP54 3515
NUP188 3510
CENPM 3488
PSMD2 3485
CENPN 3464
NCAPH 3362
DSN1 3232
PSMD9 3215
CDCA5 3175
PPP2R5C 3153
RCC2 3142
CSNK2B 3108
APITD1 3086
TUBGCP2 3059
NUP50 2999
PSMD7 2963
NEK2 2954
HAUS6 2952
RAE1 2950
BIRC5 2843
ENSA 2792
NCAPH2 2787
CENPL 2744
NME7 2648
NUP210 2605
ESPL1 2600
CEP135 2548
NCAPG 2538
ZWINT 2506
RB1 2475
NUP214 2474
CDK1 2450
DYNC1I2 2439
PSME1 2379
AAAS 2354
PSME2 2344
VPS4A 2335
CENPK 2332
LEMD3 2330
PSMB6 2326
ANAPC7 2305
TPR 2275
CENPO 2243
CSNK1D 2239
SKA2 2224
CEP192 2199
CLIP1 2164
NUP98 2149
KIF23 2145
NUP153 2123
RAB1B 2090
DYNC1LI1 2070
MCPH1 2053
CENPT 2029
FBXO5 1996
NUP62 1978
PLK4 1944
BANF1 1929
PSMD6 1908
TUBA1B 1859
BUB1B 1793
CEP152 1653
SMC2 1629
EML4 1602
PSMC4 1563
CLASP1 1549
PPP2R5A 1532
UBA52 1530
GOLGA2 1523
MAD2L1 1421
PSMD8 1397
HAUS2 1391
SPC24 1317
KIF2A 1265
PSMB1 1218
CHMP2B 1172
HAUS4 1165
PPP2R2A 1125
TUBG2 1108
ANAPC5 1095
PPP2R5B 1078
NUP107 902
CENPE 899
PPP2R5E 863
CENPQ 788
NUP155 778
TUBA4A 757
PSMD4 754
CEP164 713
ARPP19 650
CHMP6 638
TMPO 629
PSMC1 611
ANAPC11 601
CDCA8 538
PSMD1 458
RPS27A 373
TUBA1A 281
PSMA6 230
PSME3 210
NDE1 191
PTTG1 144
CDC23 84
PSMD12 20
ANKLE2 -8
UBB -13
RAD21 -54
NEK6 -68
PPP1CC -109
PLK1 -118
ZW10 -133
HAUS1 -139
UBE2D1 -157
PSMB10 -165
RANGAP1 -174
CSNK2A2 -188
ANAPC10 -361
BUB3 -425
DYNC1LI2 -456
PSMB7 -481
CDC20 -491
GORASP2 -692
CSNK1E -729
H2AFX -738
CHMP4B -830
NUP133 -1034
UBC -1067
PSMB5 -1101
NUP160 -1133
MAPK1 -1146
AHCTF1 -1162
RAN -1174
MAPRE1 -1239
RANBP2 -1283
PRKACA -1287
UBE2E1 -1323
NUP35 -1373
SPC25 -1447
MAPK3 -1492
ZWILCH -1593
ALMS1 -1625
HAUS5 -1633
VRK2 -1683
UBE2C -1688
CLASP2 -1727
PSMC3 -1757
PCNT -1852
CENPH -1863
BUB1 -1899
SUMO1 -2075
PPP2R5D -2111
NUP93 -2168
YWHAE -2211
KNTC1 -2217
ITGB3BP -2272
CDC16 -2388
NUF2 -2397
TUBB2A -2479
CDK5RAP2 -2525
DCTN2 -2552
NUMA1 -2615
PSMF1 -2618
LMNA -2632
TUBGCP5 -2707
SET -2876


Activation of NMDA receptors and postsynaptic events

Activation of NMDA receptors and postsynaptic events
32
set Activation of NMDA receptors and postsynaptic events
setSize 43
pANOVA 0.00151
s.dist -0.28
p.adjustANOVA 0.129



Top enriched genes

Top 20 genes
GeneID Gene Rank
GIT1 -3090
PRKAR1B -3015
HRAS -2761
RPS6KA1 -2723
CAMK1 -2658
PRKAR2A -2557
GRIN1 -2485
GRIN2C -2408
GRIN2D -2134
CAMKK2 -2051
NBEA -1866
APBA1 -1859
PPM1F -1585
MAPK3 -1492
PRKACA -1287
DLG4 -1172
PRKAA1 -1152
MAPK1 -1146
CAMK2G -829
LIN7B -741

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GIT1 -3090
PRKAR1B -3015
HRAS -2761
RPS6KA1 -2723
CAMK1 -2658
PRKAR2A -2557
GRIN1 -2485
GRIN2C -2408
GRIN2D -2134
CAMKK2 -2051
NBEA -1866
APBA1 -1859
PPM1F -1585
MAPK3 -1492
PRKACA -1287
DLG4 -1172
PRKAA1 -1152
MAPK1 -1146
CAMK2G -829
LIN7B -741
CALM1 -703
SRC -427
KRAS 138
MAPT 201
CREB1 472
LIN7C 606
NRGN 776
ARHGEF7 1038
PRKAB2 1621
RAC1 1706
PRKACB 2348
CAMK4 2726
DLG1 2874
KIF17 2947
RPS6KA2 3112
PDPK1 3800
KPNA2 4362
PRKAG2 4444
CAMKK1 4543
PRKAG1 4778
PRKAR1A 4900
PRKAB1 5662
CAMK2D 6135


SARS-CoV Infections

SARS-CoV Infections
855
set SARS-CoV Infections
setSize 109
pANOVA 0.00157
s.dist 0.176
p.adjustANOVA 0.129



Top enriched genes

Top 20 genes
GeneID Gene Rank
ST6GALNAC3 6703
PARP10 6688
PARP8 6633
S1PR1 6602
TLR9 6559
KDM1A 6473
PHF21A 6450
PRKCSH 6429
PTGES3 6314
GSK3A 6226
IFNGR2 6161
TUBB 6157
UVRAG 6091
ATP1B3 6036
ST3GAL3 5961
IFNAR1 5949
PARP4 5852
DDX5 5815
CHD3 5715
IMPDH2 5708

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ST6GALNAC3 6703
PARP10 6688
PARP8 6633
S1PR1 6602
TLR9 6559
KDM1A 6473
PHF21A 6450
PRKCSH 6429
PTGES3 6314
GSK3A 6226
IFNGR2 6161
TUBB 6157
UVRAG 6091
ATP1B3 6036
ST3GAL3 5961
IFNAR1 5949
PARP4 5852
DDX5 5815
CHD3 5715
IMPDH2 5708
MAN2A1 5584
ST3GAL1 5472
GATAD2A 5332
UBE2I 5265
MOGS 5254
TYK2 5218
GSK3B 5172
CRBN 5169
MBD3 5082
EDEM2 5003
NR3C1 5002
RCOR1 4991
PARP9 4948
ROCK1 4937
MGAT2 4928
SUDS3 4899
AP2A1 4882
RPN1 4758
PARP6 4693
CHMP7 4685
PARP14 4616
MGAT4A 4472
HSP90AA1 4393
GATAD2B 4125
STT3A 4108
CHMP2A 3751
MGAT1 3602
SAP30 3595
CHMP4A 3557
REST 3519
PARP16 3416
MTA2 3226
DAD1 3143
BRMS1 3097
ATP1A3 3006
ATP1B1 2919
HDAC1 2753
SIGMAR1 2732
FUT8 2692
MAP1LC3B 2686
PIK3R4 2484
RB1 2475
SAP18 2391
ST6GAL1 2215
FKBP4 2181
CHD4 2045
SAP30L 1664
TBK1 1627
GANAB 1614
ITGA4 1601
VHL 1575
UBA52 1530
CHMP2B 1172
HDAC2 944
IFNAR2 885
CHMP6 638
ATP1A1 481
RPS27A 373
HMG20B 327
MTA3 320
BRD4 308
RBBP4 290
ST3GAL2 235
JAK2 227
IFNGR1 186
VEGFA 73
UBB -13
FKBP1A -26
ST6GALNAC4 -193
BECN1 -198
MGAT5 -200
AP2M1 -611
RPN2 -773
CHMP4B -830
VCP -905
UBC -1067
ST3GAL4 -1527
HSP90AB1 -1669
CANX -1853
IMPDH1 -1918
COMT -1986
IL6R -2047
SUMO1 -2075
MAN1B1 -2337
AP2S1 -2469
MGAT4B -2560
JAK1 -2617
STAT2 -2692
FURIN -2837


Arachidonic acid metabolism

Arachidonic acid metabolism
58
set Arachidonic acid metabolism
setSize 21
pANOVA 0.00161
s.dist -0.398
p.adjustANOVA 0.129



Top enriched genes

Top 20 genes
GeneID Gene Rank
LTC4S -3059
TBXAS1 -3040
DPEP2 -2945
PTGR1 -2749
ALOX5AP -2718
EPHX2 -2620
GGT1 -2492
ALOX5 -2277
HPGD -1601
PTGR2 -1591
PON2 -728
ABCC1 -468
CYP2U1 -150
ALOXE3 -136
GPX1 130
PTGES2 1595
MAPKAPK2 2498
GPX4 3511
CYP4F22 4630
LTA4H 4946

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LTC4S -3059
TBXAS1 -3040
DPEP2 -2945
PTGR1 -2749
ALOX5AP -2718
EPHX2 -2620
GGT1 -2492
ALOX5 -2277
HPGD -1601
PTGR2 -1591
PON2 -728
ABCC1 -468
CYP2U1 -150
ALOXE3 -136
GPX1 130
PTGES2 1595
MAPKAPK2 2498
GPX4 3511
CYP4F22 4630
LTA4H 4946
PTGES3 6314


Integrin signaling

Integrin signaling
427
set Integrin signaling
setSize 16
pANOVA 0.00169
s.dist 0.454
p.adjustANOVA 0.129



Top enriched genes

Top 20 genes
GeneID Gene Rank
SYK 6538
PTK2 6515
PTPN1 6442
SHC1 6208
RAP1A 6166
RASGRP2 5924
CSK 5596
RAP1B 5399
AKT1 4880
RASGRP1 3802
PDPK1 3800
TLN1 3119
APBB1IP 2219
GRB2 448
SRC -427
CRK -1792

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SYK 6538
PTK2 6515
PTPN1 6442
SHC1 6208
RAP1A 6166
RASGRP2 5924
CSK 5596
RAP1B 5399
AKT1 4880
RASGRP1 3802
PDPK1 3800
TLN1 3119
APBB1IP 2219
GRB2 448
SRC -427
CRK -1792


Platelet Aggregation (Plug Formation)

Platelet Aggregation (Plug Formation)
662
set Platelet Aggregation (Plug Formation)
setSize 16
pANOVA 0.00169
s.dist 0.454
p.adjustANOVA 0.129



Top enriched genes

Top 20 genes
GeneID Gene Rank
SYK 6538
PTK2 6515
PTPN1 6442
SHC1 6208
RAP1A 6166
RASGRP2 5924
CSK 5596
RAP1B 5399
AKT1 4880
RASGRP1 3802
PDPK1 3800
TLN1 3119
APBB1IP 2219
GRB2 448
SRC -427
CRK -1792

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SYK 6538
PTK2 6515
PTPN1 6442
SHC1 6208
RAP1A 6166
RASGRP2 5924
CSK 5596
RAP1B 5399
AKT1 4880
RASGRP1 3802
PDPK1 3800
TLN1 3119
APBB1IP 2219
GRB2 448
SRC -427
CRK -1792


Regulation of FZD by ubiquitination

Regulation of FZD by ubiquitination
792
set Regulation of FZD by ubiquitination
setSize 12
pANOVA 0.0026
s.dist -0.502
p.adjustANOVA 0.174



Top enriched genes

Top 20 genes
GeneID Gene Rank
WNT3A -2648
FZD6 -2600
FZD8 -2186
LRP5 -1551
USP8 -1196
FZD5 -1117
LRP6 -1105
UBC -1067
UBB -13
RPS27A 373
UBA52 1530
ZNRF3 3698

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT3A -2648
FZD6 -2600
FZD8 -2186
LRP5 -1551
USP8 -1196
FZD5 -1117
LRP6 -1105
UBC -1067
UBB -13
RPS27A 373
UBA52 1530
ZNRF3 3698


Maturation of nucleoprotein

Maturation of nucleoprotein
496
set Maturation of nucleoprotein
setSize 10
pANOVA 0.00268
s.dist 0.548
p.adjustANOVA 0.174



Top enriched genes

Top 20 genes
GeneID Gene Rank
PARP10 6688
PARP8 6633
PARP4 5852
UBE2I 5265
GSK3B 5172
PARP9 4948
PARP6 4693
PARP14 4616
PARP16 3416
SUMO1 -2075

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARP10 6688
PARP8 6633
PARP4 5852
UBE2I 5265
GSK3B 5172
PARP9 4948
PARP6 4693
PARP14 4616
PARP16 3416
SUMO1 -2075


Chromatin modifying enzymes

Chromatin modifying enzymes
136
set Chromatin modifying enzymes
setSize 137
pANOVA 0.00303
s.dist 0.147
p.adjustANOVA 0.174



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPC1 6719
YEATS4 6660
HDAC3 6558
SMARCA4 6535
KDM1A 6473
PHF21A 6450
NSD1 6411
ARID5B 6379
ENY2 6339
VPS72 6308
KDM6B 6246
HDAC10 6078
DMAP1 6060
KDM4C 5917
WDR77 5761
KDM2A 5728
DPY30 5725
CHD3 5715
BRPF1 5639
MSL1 5592

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPC1 6719
YEATS4 6660
HDAC3 6558
SMARCA4 6535
KDM1A 6473
PHF21A 6450
NSD1 6411
ARID5B 6379
ENY2 6339
VPS72 6308
KDM6B 6246
HDAC10 6078
DMAP1 6060
KDM4C 5917
WDR77 5761
KDM2A 5728
DPY30 5725
CHD3 5715
BRPF1 5639
MSL1 5592
EZH2 5422
YEATS2 5372
GATAD2A 5332
USP22 5326
WDR5 5173
SMARCB1 5132
TADA2A 5106
MBD3 5082
TAF9 5067
RCOR1 4991
PRMT3 4982
SUDS3 4899
NCOA2 4839
ACTB 4760
TAF10 4705
SETD3 4633
EP400 4622
SETDB1 4610
TAF6L 4598
EED 4593
EP300 4582
SMARCD1 4559
PRMT1 4375
ELP4 4368
ACTL6A 4239
SUPT3H 4228
ARID1B 4127
GATAD2B 4125
GPS2 4092
RUVBL1 4056
TBL1XR1 4052
ELP2 4021
SMARCA2 3992
MBIP 3823
BRD1 3813
KAT5 3717
SAP30 3595
KDM3A 3579
REST 3519
SETD1A 3378
BRPF3 3320
EHMT2 3294
MTA2 3226
BRMS1 3097
MCRS1 3078
ASH2L 3023
KDM1B 2965
KAT2B 2949
SETD2 2897
ASH1L 2789
ZZZ3 2776
HDAC1 2753
ING5 2620
ATXN7 2501
KDM4D 2451
SAP18 2391
TAF12 2247
JMJD6 2152
CHD4 2045
ATXN7L3 1904
SMARCC2 1902
CDK4 1863
TADA2B 1823
ING3 1820
SAP30L 1664
ARID2 1635
KDM4A 1526
ING4 1393
SMARCE1 1389
SETDB2 1354
SAP130 1182
RBBP5 1153
IKBKAP 1148
DR1 972
HDAC2 944
ELP3 801
KDM4B 692
KDM5A 585
MEAF6 551
KAT2A 438
TADA1 415
EHMT1 328
HMG20B 327
MTA3 320
RBBP4 290
TRRAP 278
JAK2 227
SMARCC1 188
MSL2 155
CLOCK 99
BRWD1 45
PRMT5 38
PHF20 -258
SMYD3 -428
SMYD2 -498
NFKB2 -613
SUPT7L -665
BRD8 -716
H2AFX -738
CCND1 -822
RUVBL2 -1068
DNMT3A -1177
RELA -1231
NCOR1 -1234
MORF4L1 -1338
ATF7IP -1371
SMARCD2 -1517
KDM3B -1709
SETD1B -2002
KDM2B -2293
PRMT7 -2330
CREBBP -2526
SUV39H2 -2535
MINA -2545
DOT1L -2612
ARID1A -2654
NCOR2 -2696


Chromatin organization

Chromatin organization
137
set Chromatin organization
setSize 137
pANOVA 0.00303
s.dist 0.147
p.adjustANOVA 0.174



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPC1 6719
YEATS4 6660
HDAC3 6558
SMARCA4 6535
KDM1A 6473
PHF21A 6450
NSD1 6411
ARID5B 6379
ENY2 6339
VPS72 6308
KDM6B 6246
HDAC10 6078
DMAP1 6060
KDM4C 5917
WDR77 5761
KDM2A 5728
DPY30 5725
CHD3 5715
BRPF1 5639
MSL1 5592

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPC1 6719
YEATS4 6660
HDAC3 6558
SMARCA4 6535
KDM1A 6473
PHF21A 6450
NSD1 6411
ARID5B 6379
ENY2 6339
VPS72 6308
KDM6B 6246
HDAC10 6078
DMAP1 6060
KDM4C 5917
WDR77 5761
KDM2A 5728
DPY30 5725
CHD3 5715
BRPF1 5639
MSL1 5592
EZH2 5422
YEATS2 5372
GATAD2A 5332
USP22 5326
WDR5 5173
SMARCB1 5132
TADA2A 5106
MBD3 5082
TAF9 5067
RCOR1 4991
PRMT3 4982
SUDS3 4899
NCOA2 4839
ACTB 4760
TAF10 4705
SETD3 4633
EP400 4622
SETDB1 4610
TAF6L 4598
EED 4593
EP300 4582
SMARCD1 4559
PRMT1 4375
ELP4 4368
ACTL6A 4239
SUPT3H 4228
ARID1B 4127
GATAD2B 4125
GPS2 4092
RUVBL1 4056
TBL1XR1 4052
ELP2 4021
SMARCA2 3992
MBIP 3823
BRD1 3813
KAT5 3717
SAP30 3595
KDM3A 3579
REST 3519
SETD1A 3378
BRPF3 3320
EHMT2 3294
MTA2 3226
BRMS1 3097
MCRS1 3078
ASH2L 3023
KDM1B 2965
KAT2B 2949
SETD2 2897
ASH1L 2789
ZZZ3 2776
HDAC1 2753
ING5 2620
ATXN7 2501
KDM4D 2451
SAP18 2391
TAF12 2247
JMJD6 2152
CHD4 2045
ATXN7L3 1904
SMARCC2 1902
CDK4 1863
TADA2B 1823
ING3 1820
SAP30L 1664
ARID2 1635
KDM4A 1526
ING4 1393
SMARCE1 1389
SETDB2 1354
SAP130 1182
RBBP5 1153
IKBKAP 1148
DR1 972
HDAC2 944
ELP3 801
KDM4B 692
KDM5A 585
MEAF6 551
KAT2A 438
TADA1 415
EHMT1 328
HMG20B 327
MTA3 320
RBBP4 290
TRRAP 278
JAK2 227
SMARCC1 188
MSL2 155
CLOCK 99
BRWD1 45
PRMT5 38
PHF20 -258
SMYD3 -428
SMYD2 -498
NFKB2 -613
SUPT7L -665
BRD8 -716
H2AFX -738
CCND1 -822
RUVBL2 -1068
DNMT3A -1177
RELA -1231
NCOR1 -1234
MORF4L1 -1338
ATF7IP -1371
SMARCD2 -1517
KDM3B -1709
SETD1B -2002
KDM2B -2293
PRMT7 -2330
CREBBP -2526
SUV39H2 -2535
MINA -2545
DOT1L -2612
ARID1A -2654
NCOR2 -2696


G2/M Transition

G2/M Transition
329
set G2/M Transition
setSize 143
pANOVA 0.00305
s.dist 0.144
p.adjustANOVA 0.174



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBGCP3 6638
TUBGCP6 6580
NEDD1 6562
MYBL2 6528
CEP76 6523
LIN9 6417
CCNB1 6272
ACTR1A 6228
SKP1 6201
TUBB 6157
PPP1R12A 6142
PSME4 5997
HMMR 5977
PAFAH1B1 5904
MNAT1 5844
CCNH 5835
RBX1 5617
CENPJ 5613
DCTN3 5566
PSMD3 5506

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBGCP3 6638
TUBGCP6 6580
NEDD1 6562
MYBL2 6528
CEP76 6523
LIN9 6417
CCNB1 6272
ACTR1A 6228
SKP1 6201
TUBB 6157
PPP1R12A 6142
PSME4 5997
HMMR 5977
PAFAH1B1 5904
MNAT1 5844
CCNH 5835
RBX1 5617
CENPJ 5613
DCTN3 5566
PSMD3 5506
PSMC5 5418
PPP2CB 5390
ODF2 5376
CENPF 5351
PSMB8 5160
OPTN 5114
PSMA2 5110
PSMA1 5104
DYNC1H1 5029
CEP78 5013
XPO1 4933
PSMD13 4927
SDCCAG8 4907
PSMB9 4898
CEP250 4881
PSMB3 4780
CDC25B 4768
GTSE1 4753
CKAP5 4720
CCNB2 4682
HAUS8 4673
DYNLL1 4607
EP300 4582
PPP2CA 4425
HSP90AA1 4393
AURKA 4365
PSMC6 4301
PSMD11 4285
CEP63 4259
PCM1 4253
PSMA3 4184
PSMA5 4135
WEE1 3951
AKAP9 3852
CDC25C 3835
CEP70 3663
PPP2R1B 3568
YWHAG 3556
TP53 3539
PSMA7 3526
PSMD14 3518
CDK11B 3493
CCNA2 3487
PSMD2 3485
LIN54 3438
PPP1R12B 3352
PSMD9 3215
TUBGCP2 3059
PPME1 2989
PSMD7 2963
NEK2 2954
HAUS6 2952
RAB8A 2929
NME7 2648
CEP135 2548
CDK1 2450
DYNC1I2 2439
PSME1 2379
PSME2 2344
PSMB6 2326
LIN37 2309
CSNK1D 2239
CEP192 2199
CDK7 1957
PLK4 1944
PSMD6 1908
FBXL18 1835
CEP152 1653
PSMC4 1563
CLASP1 1549
UBA52 1530
LCMT1 1427
PSMD8 1397
HAUS2 1391
FOXM1 1373
PSMB1 1218
HAUS4 1165
PPP2R2A 1125
TUBG2 1108
CDK2 1071
TUBA4A 757
PSMD4 754
CEP164 713
PSMC1 611
PSMD1 458
RPS27A 373
TPX2 313
RBBP4 290
TUBA1A 281
PSMA6 230
PSME3 210
NDE1 191
FKBPL 39
PSMD12 20
UBB -13
PLK1 -118
HAUS1 -139
PSMB10 -165
LIN52 -467
PSMB7 -481
PPP1CB -558
CDKN1A -682
CSNK1E -729
PKMYT1 -825
CDC25A -1059
UBC -1067
PSMB5 -1101
MAPRE1 -1239
PRKACA -1287
BTRC -1346
ALMS1 -1625
HAUS5 -1633
HSP90AB1 -1669
PSMC3 -1757
PCNT -1852
YWHAE -2211
PHLDA1 -2341
CDK5RAP2 -2525
DCTN2 -2552
CDK11A -2613
PSMF1 -2618
TUBGCP5 -2707
CUL1 -2993


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.1.0 (2021-05-18)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/liblapack.so.3
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.1                                      
##  [2] GGally_2.1.1                                       
##  [3] ggplot2_3.3.3                                      
##  [4] gtools_3.8.2                                       
##  [5] tibble_3.1.2                                       
##  [6] dplyr_1.0.6                                        
##  [7] echarts4r_0.4.0                                    
##  [8] ENmix_1.25.1                                       
##  [9] doParallel_1.0.16                                  
## [10] qqman_0.1.8                                        
## [11] RCircos_1.2.1                                      
## [12] DMRcatedata_2.6.0                                  
## [13] ExperimentHub_1.14.2                               
## [14] AnnotationHub_2.20.2                               
## [15] BiocFileCache_1.12.1                               
## [16] dbplyr_2.1.1                                       
## [17] beeswarm_0.3.1                                     
## [18] reshape2_1.4.4                                     
## [19] gplots_3.1.1                                       
## [20] eulerr_6.1.0                                       
## [21] R.utils_2.10.1                                     
## [22] R.oo_1.24.0                                        
## [23] R.methodsS3_1.8.1                                  
## [24] plyr_1.8.6                                         
## [25] RColorBrewer_1.1-2                                 
## [26] forestplot_1.10.1                                  
## [27] checkmate_2.0.0                                    
## [28] magrittr_2.0.1                                     
## [29] kableExtra_1.3.4                                   
## [30] mitch_1.0.10                                       
## [31] DMRcate_2.2.3                                      
## [32] IlluminaHumanMethylation450kmanifest_0.4.0         
## [33] topconfects_1.4.0                                  
## [34] limma_3.44.3                                       
## [35] GEOquery_2.56.0                                    
## [36] missMethyl_1.22.0                                  
## [37] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [38] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.0 
## [39] minfi_1.34.0                                       
## [40] bumphunter_1.30.0                                  
## [41] locfit_1.5-9.4                                     
## [42] iterators_1.0.13                                   
## [43] foreach_1.5.1                                      
## [44] Biostrings_2.56.0                                  
## [45] XVector_0.28.0                                     
## [46] SummarizedExperiment_1.18.2                        
## [47] DelayedArray_0.14.1                                
## [48] matrixStats_0.58.0                                 
## [49] Biobase_2.48.0                                     
## [50] GenomicRanges_1.40.0                               
## [51] GenomeInfoDb_1.24.2                                
## [52] IRanges_2.22.2                                     
## [53] S4Vectors_0.26.1                                   
## [54] BiocGenerics_0.34.0                                
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.48.0           
##   [3] tidyr_1.1.3                   bit64_4.0.5                  
##   [5] knitr_1.33                    data.table_1.14.0            
##   [7] rpart_4.1-15                  RCurl_1.98-1.3               
##   [9] AnnotationFilter_1.12.0       generics_0.1.0               
##  [11] GenomicFeatures_1.40.1        preprocessCore_1.50.0        
##  [13] RSQLite_2.2.7                 bit_4.0.4                    
##  [15] webshot_0.5.2                 xml2_1.3.2                   
##  [17] httpuv_1.6.1                  assertthat_0.2.1             
##  [19] xfun_0.23                     hms_1.1.0                    
##  [21] jquerylib_0.1.4               evaluate_0.14                
##  [23] promises_1.2.0.1              fansi_0.4.2                  
##  [25] scrime_1.3.5                  progress_1.2.2               
##  [27] caTools_1.18.2                readxl_1.3.1                 
##  [29] DBI_1.1.1                     geneplotter_1.66.0           
##  [31] htmlwidgets_1.5.3             reshape_0.8.8                
##  [33] purrr_0.3.4                   ellipsis_0.3.2               
##  [35] backports_1.2.1               permute_0.9-5                
##  [37] calibrate_1.7.7               annotate_1.66.0              
##  [39] biomaRt_2.44.4                vctrs_0.3.8                  
##  [41] ensembldb_2.12.1              withr_2.4.2                  
##  [43] cachem_1.0.5                  Gviz_1.32.0                  
##  [45] BSgenome_1.56.0               GenomicAlignments_1.24.0     
##  [47] prettyunits_1.1.1             mclust_5.4.7                 
##  [49] svglite_2.0.0                 cluster_2.1.2                
##  [51] RPMM_1.25                     lazyeval_0.2.2               
##  [53] crayon_1.4.1                  genefilter_1.70.0            
##  [55] edgeR_3.30.3                  pkgconfig_2.0.3              
##  [57] nlme_3.1-152                  ProtGenerics_1.20.0          
##  [59] nnet_7.3-16                   rlang_0.4.11                 
##  [61] lifecycle_1.0.0               dichromat_2.0-0              
##  [63] rprojroot_2.0.2               cellranger_1.1.0             
##  [65] rngtools_1.5                  base64_2.0                   
##  [67] Matrix_1.3-3                  Rhdf5lib_1.10.1              
##  [69] base64enc_0.1-3               png_0.1-7                    
##  [71] viridisLite_0.4.0             bitops_1.0-7                 
##  [73] KernSmooth_2.23-20            blob_1.2.1                   
##  [75] DelayedMatrixStats_1.10.1     doRNG_1.8.2                  
##  [77] stringr_1.4.0                 nor1mix_1.3-0                
##  [79] readr_1.4.0                   jpeg_0.1-8.1                 
##  [81] scales_1.1.1                  lpSolve_5.6.15               
##  [83] memoise_2.0.0                 zlibbioc_1.34.0              
##  [85] compiler_4.1.0                illuminaio_0.30.0            
##  [87] Rsamtools_2.4.0               DSS_2.36.0                   
##  [89] htmlTable_2.2.1               Formula_1.2-4                
##  [91] MASS_7.3-54                   tidyselect_1.1.1             
##  [93] stringi_1.6.2                 highr_0.9                    
##  [95] yaml_2.2.1                    askpass_1.1                  
##  [97] latticeExtra_0.6-29           sass_0.4.0                   
##  [99] VariantAnnotation_1.34.0      tools_4.1.0                  
## [101] rstudioapi_0.13               foreign_0.8-81               
## [103] bsseq_1.24.4                  gridExtra_2.3                
## [105] digest_0.6.27                 BiocManager_1.30.15          
## [107] shiny_1.6.0                   quadprog_1.5-8               
## [109] Rcpp_1.0.6                    siggenes_1.62.0              
## [111] BiocVersion_3.11.1            later_1.2.0                  
## [113] org.Hs.eg.db_3.11.4           httr_1.4.2                   
## [115] AnnotationDbi_1.50.3          biovizBase_1.36.0            
## [117] colorspace_2.0-1              rvest_1.0.0                  
## [119] XML_3.99-0.6                  splines_4.1.0                
## [121] statmod_1.4.36                multtest_2.44.0              
## [123] irr_0.84.1                    systemfonts_1.0.2            
## [125] xtable_1.8-4                  jsonlite_1.7.2               
## [127] dynamicTreeCut_1.63-1         testthat_3.0.2               
## [129] R6_2.5.0                      Hmisc_4.5-0                  
## [131] pillar_1.6.1                  htmltools_0.5.1.1            
## [133] mime_0.10                     glue_1.4.2                   
## [135] fastmap_1.1.0                 BiocParallel_1.22.0          
## [137] interactiveDisplayBase_1.26.3 beanplot_1.2                 
## [139] codetools_0.2-18              utf8_1.2.1                   
## [141] lattice_0.20-44               bslib_0.2.5.1                
## [143] curl_4.3.1                    openssl_1.4.4                
## [145] survival_3.2-11               rmarkdown_2.8                
## [147] desc_1.3.0                    munsell_0.5.0                
## [149] rhdf5_2.32.4                  GenomeInfoDbData_1.2.3       
## [151] HDF5Array_1.16.1              impute_1.62.0                
## [153] gtable_0.3.0

END of report