Mitch Report

date generated: 2022-05-08

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##          wholegene   promoter
## A1BG  -0.147977708 -0.5005966
## AAAS  -0.552268508 -0.7353304
## AACS  -0.006703247 -0.4766486
## AAGAB -1.694585234 -1.9635751
## AAK1  -0.452056724 -0.4299606
## AAMP  -1.109626025 -1.5988949

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	9840
duplicated_genes_present	0
num_profile_genes_in_sets	5255
num_profile_genes_not_in_sets	4585
profile_pearson_correl	0.56467
profile_spearman_correl	0.70749

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1377
num_genesets_included	1169

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 6

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.wholegene	s.promoter	p.wholegene	p.promoter
Negative regulation of NMDA receptor-mediated neuronal transmission	11	0.004980	0.1140	0.713	0.565	0.4350	1.18e-03	0.012600
Purine catabolism	10	0.023100	0.2280	0.654	-0.448	-0.4760	1.41e-02	0.009170
Long-term potentiation	10	0.005540	0.1150	0.645	0.571	0.3010	1.78e-03	0.098900
p75NTR signals via NF-kB	11	0.019900	0.2220	0.636	-0.461	-0.4390	8.19e-03	0.011800
Ras activation upon Ca2+ influx through NMDA receptor	10	0.055600	0.3700	0.568	0.426	0.3760	1.96e-02	0.039600
Meiotic recombination	19	0.003570	0.1040	0.561	-0.345	-0.4430	9.30e-03	0.000838
Resolution of D-loop Structures through Holliday Junction Intermediates	24	0.000638	0.0586	0.547	-0.452	-0.3080	1.26e-04	0.009010
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	19	0.002240	0.0750	0.538	-0.459	-0.2820	5.35e-04	0.033600
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	19	0.002240	0.0750	0.538	-0.459	-0.2820	5.35e-04	0.033600
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	19	0.002240	0.0750	0.538	-0.459	-0.2820	5.35e-04	0.033600
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	19	0.002240	0.0750	0.538	-0.459	-0.2820	5.35e-04	0.033600
Impaired BRCA2 binding to PALB2	19	0.002240	0.0750	0.538	-0.459	-0.2820	5.35e-04	0.033600
Resolution of D-Loop Structures	25	0.000503	0.0586	0.538	-0.449	-0.2960	1.01e-04	0.010500
Potassium Channels	23	0.004780	0.1120	0.514	0.351	0.3740	3.55e-03	0.001890
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	21	0.003690	0.1050	0.513	-0.422	-0.2910	8.18e-04	0.020900
RORA activates gene expression	11	0.013500	0.1900	0.511	0.472	0.1950	6.73e-03	0.262000
Impaired BRCA2 binding to RAD51	30	0.001730	0.0750	0.489	-0.363	-0.3270	5.80e-04	0.001960
IKK complex recruitment mediated by RIP1	17	0.024200	0.2310	0.482	-0.296	-0.3800	3.50e-02	0.006630
Glycogen synthesis	11	0.105000	0.4560	0.480	-0.358	-0.3190	3.96e-02	0.066900
A tetrasaccharide linker sequence is required for GAG synthesis	10	0.099200	0.4460	0.478	0.393	0.2730	3.16e-02	0.135000
SARS-CoV-2 modulates autophagy	10	0.134000	0.4910	0.465	-0.290	-0.3630	1.12e-01	0.046700
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	25	0.007140	0.1350	0.458	-0.362	-0.2810	1.75e-03	0.015100
Signaling by Leptin	10	0.028400	0.2460	0.455	0.145	0.4310	4.27e-01	0.018200
Mitochondrial tRNA aminoacylation	17	0.036900	0.2950	0.446	-0.263	-0.3600	6.08e-02	0.010200
DCC mediated attractive signaling	11	0.006420	0.1270	0.443	0.437	0.0698	1.20e-02	0.689000
Pexophagy	11	0.137000	0.4910	0.442	-0.344	-0.2770	4.81e-02	0.112000
Signaling by BMP	14	0.004290	0.1120	0.442	0.108	0.4280	4.85e-01	0.005530
Signaling by WNT in cancer	22	0.023200	0.2280	0.441	0.308	0.3160	1.23e-02	0.010400
Caspase activation via Death Receptors in the presence of ligand	10	0.178000	0.5190	0.439	-0.290	-0.3300	1.12e-01	0.071100
Translesion Synthesis by POLH	16	0.064500	0.3790	0.439	-0.292	-0.3270	4.33e-02	0.023500
Signaling by Hippo	10	0.081100	0.4160	0.438	0.393	0.1950	3.16e-02	0.285000
Activation of kainate receptors upon glutamate binding	15	0.076700	0.4060	0.437	0.287	0.3290	5.47e-02	0.027200
TICAM1, RIP1-mediated IKK complex recruitment	17	0.059400	0.3720	0.433	-0.292	-0.3200	3.72e-02	0.022500
Presynaptic phase of homologous DNA pairing and strand exchange	32	0.005180	0.1150	0.432	-0.314	-0.2970	2.10e-03	0.003670
Negative regulation of FLT3	10	0.193000	0.5390	0.432	-0.296	-0.3150	1.06e-01	0.084800
Mucopolysaccharidoses	10	0.154000	0.5120	0.429	0.244	0.3530	1.81e-01	0.053200
Assembly and cell surface presentation of NMDA receptors	12	0.143000	0.4910	0.429	0.298	0.3090	7.42e-02	0.063700
Interleukin-10 signaling	12	0.140000	0.4910	0.425	0.276	0.3240	9.85e-02	0.052100
tRNA Aminoacylation	22	0.011900	0.1750	0.424	-0.219	-0.3630	7.53e-02	0.003210
Mitochondrial calcium ion transport	14	0.101000	0.4490	0.423	0.269	0.3260	8.11e-02	0.034700
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	33	0.005370	0.1150	0.421	-0.316	-0.2780	1.69e-03	0.005660
Diseases of DNA Double-Strand Break Repair	33	0.005370	0.1150	0.421	-0.316	-0.2780	1.69e-03	0.005660
RHO GTPases activate CIT	14	0.107000	0.4590	0.420	-0.273	-0.3190	7.66e-02	0.038700
Defects in vitamin and cofactor metabolism	16	0.067300	0.3820	0.418	-0.335	-0.2500	2.04e-02	0.083300
Chaperone Mediated Autophagy	12	0.150000	0.5050	0.415	-0.263	-0.3210	1.15e-01	0.054400
Ion homeostasis	25	0.004660	0.1120	0.414	0.367	0.1930	1.51e-03	0.095200
HDR through Homologous Recombination (HRR)	55	0.000239	0.0466	0.414	-0.306	-0.2800	8.89e-05	0.000338
HDMs demethylate histones	15	0.065400	0.3790	0.414	-0.226	-0.3470	1.29e-01	0.019900
Processing of Intronless Pre-mRNAs	15	0.046400	0.3380	0.414	-0.202	-0.3620	1.77e-01	0.015300
Rap1 signalling	11	0.176000	0.5160	0.412	-0.322	-0.2570	6.44e-02	0.140000

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.wholegene	s.promoter	p.wholegene	p.promoter
Negative regulation of NMDA receptor-mediated neuronal transmission	11	4.98e-03	0.11400	0.71300	5.65e-01	0.435000	1.18e-03	1.26e-02
Purine catabolism	10	2.31e-02	0.22800	0.65400	-4.48e-01	-0.476000	1.41e-02	9.17e-03
Long-term potentiation	10	5.54e-03	0.11500	0.64500	5.71e-01	0.301000	1.78e-03	9.89e-02
p75NTR signals via NF-kB	11	1.99e-02	0.22200	0.63600	-4.61e-01	-0.439000	8.19e-03	1.18e-02
Ras activation upon Ca2+ influx through NMDA receptor	10	5.56e-02	0.37000	0.56800	4.26e-01	0.376000	1.96e-02	3.96e-02
Meiotic recombination	19	3.57e-03	0.10400	0.56100	-3.45e-01	-0.443000	9.30e-03	8.38e-04
Resolution of D-loop Structures through Holliday Junction Intermediates	24	6.38e-04	0.05860	0.54700	-4.52e-01	-0.308000	1.26e-04	9.01e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	19	2.24e-03	0.07500	0.53800	-4.59e-01	-0.282000	5.35e-04	3.36e-02
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	19	2.24e-03	0.07500	0.53800	-4.59e-01	-0.282000	5.35e-04	3.36e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	19	2.24e-03	0.07500	0.53800	-4.59e-01	-0.282000	5.35e-04	3.36e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	19	2.24e-03	0.07500	0.53800	-4.59e-01	-0.282000	5.35e-04	3.36e-02
Impaired BRCA2 binding to PALB2	19	2.24e-03	0.07500	0.53800	-4.59e-01	-0.282000	5.35e-04	3.36e-02
Resolution of D-Loop Structures	25	5.03e-04	0.05860	0.53800	-4.49e-01	-0.296000	1.01e-04	1.05e-02
Potassium Channels	23	4.78e-03	0.11200	0.51400	3.51e-01	0.374000	3.55e-03	1.89e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	21	3.69e-03	0.10500	0.51300	-4.22e-01	-0.291000	8.18e-04	2.09e-02
RORA activates gene expression	11	1.35e-02	0.19000	0.51100	4.72e-01	0.195000	6.73e-03	2.62e-01
Impaired BRCA2 binding to RAD51	30	1.73e-03	0.07500	0.48900	-3.63e-01	-0.327000	5.80e-04	1.96e-03
IKK complex recruitment mediated by RIP1	17	2.42e-02	0.23100	0.48200	-2.96e-01	-0.380000	3.50e-02	6.63e-03
Glycogen synthesis	11	1.05e-01	0.45600	0.48000	-3.58e-01	-0.319000	3.96e-02	6.69e-02
A tetrasaccharide linker sequence is required for GAG synthesis	10	9.92e-02	0.44600	0.47800	3.93e-01	0.273000	3.16e-02	1.35e-01
SARS-CoV-2 modulates autophagy	10	1.34e-01	0.49100	0.46500	-2.90e-01	-0.363000	1.12e-01	4.67e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	25	7.14e-03	0.13500	0.45800	-3.62e-01	-0.281000	1.75e-03	1.51e-02
Signaling by Leptin	10	2.84e-02	0.24600	0.45500	1.45e-01	0.431000	4.27e-01	1.82e-02
Mitochondrial tRNA aminoacylation	17	3.69e-02	0.29500	0.44600	-2.63e-01	-0.360000	6.08e-02	1.02e-02
DCC mediated attractive signaling	11	6.42e-03	0.12700	0.44300	4.37e-01	0.069800	1.20e-02	6.89e-01
Pexophagy	11	1.37e-01	0.49100	0.44200	-3.44e-01	-0.277000	4.81e-02	1.12e-01
Signaling by BMP	14	4.29e-03	0.11200	0.44200	1.08e-01	0.428000	4.85e-01	5.53e-03
Signaling by WNT in cancer	22	2.32e-02	0.22800	0.44100	3.08e-01	0.316000	1.23e-02	1.04e-02
Caspase activation via Death Receptors in the presence of ligand	10	1.78e-01	0.51900	0.43900	-2.90e-01	-0.330000	1.12e-01	7.11e-02
Translesion Synthesis by POLH	16	6.45e-02	0.37900	0.43900	-2.92e-01	-0.327000	4.33e-02	2.35e-02
Signaling by Hippo	10	8.11e-02	0.41600	0.43800	3.93e-01	0.195000	3.16e-02	2.85e-01
Activation of kainate receptors upon glutamate binding	15	7.67e-02	0.40600	0.43700	2.87e-01	0.329000	5.47e-02	2.72e-02
TICAM1, RIP1-mediated IKK complex recruitment	17	5.94e-02	0.37200	0.43300	-2.92e-01	-0.320000	3.72e-02	2.25e-02
Presynaptic phase of homologous DNA pairing and strand exchange	32	5.18e-03	0.11500	0.43200	-3.14e-01	-0.297000	2.10e-03	3.67e-03
Negative regulation of FLT3	10	1.93e-01	0.53900	0.43200	-2.96e-01	-0.315000	1.06e-01	8.48e-02
Mucopolysaccharidoses	10	1.54e-01	0.51200	0.42900	2.44e-01	0.353000	1.81e-01	5.32e-02
Assembly and cell surface presentation of NMDA receptors	12	1.43e-01	0.49100	0.42900	2.98e-01	0.309000	7.42e-02	6.37e-02
Interleukin-10 signaling	12	1.40e-01	0.49100	0.42500	2.76e-01	0.324000	9.85e-02	5.21e-02
tRNA Aminoacylation	22	1.19e-02	0.17500	0.42400	-2.19e-01	-0.363000	7.53e-02	3.21e-03
Mitochondrial calcium ion transport	14	1.01e-01	0.44900	0.42300	2.69e-01	0.326000	8.11e-02	3.47e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	33	5.37e-03	0.11500	0.42100	-3.16e-01	-0.278000	1.69e-03	5.66e-03
Diseases of DNA Double-Strand Break Repair	33	5.37e-03	0.11500	0.42100	-3.16e-01	-0.278000	1.69e-03	5.66e-03
RHO GTPases activate CIT	14	1.07e-01	0.45900	0.42000	-2.73e-01	-0.319000	7.66e-02	3.87e-02
Defects in vitamin and cofactor metabolism	16	6.73e-02	0.38200	0.41800	-3.35e-01	-0.250000	2.04e-02	8.33e-02
Chaperone Mediated Autophagy	12	1.50e-01	0.50500	0.41500	-2.63e-01	-0.321000	1.15e-01	5.44e-02
Ion homeostasis	25	4.66e-03	0.11200	0.41400	3.67e-01	0.193000	1.51e-03	9.52e-02
HDR through Homologous Recombination (HRR)	55	2.39e-04	0.04660	0.41400	-3.06e-01	-0.280000	8.89e-05	3.38e-04
HDMs demethylate histones	15	6.54e-02	0.37900	0.41400	-2.26e-01	-0.347000	1.29e-01	1.99e-02
Processing of Intronless Pre-mRNAs	15	4.64e-02	0.33800	0.41400	-2.02e-01	-0.362000	1.77e-01	1.53e-02
Rap1 signalling	11	1.76e-01	0.51600	0.41200	-3.22e-01	-0.257000	6.44e-02	1.40e-01
Ephrin signaling	11	1.12e-01	0.46300	0.41100	3.57e-01	0.202000	4.02e-02	2.46e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	15	9.44e-02	0.43600	0.41000	-2.53e-01	-0.322000	9.03e-02	3.08e-02
NRIF signals cell death from the nucleus	13	6.22e-02	0.37900	0.40900	-3.64e-01	-0.187000	2.31e-02	2.44e-01
Removal of the Flap Intermediate from the C-strand	15	1.17e-01	0.46600	0.40100	-3.00e-01	-0.266000	4.45e-02	7.46e-02
RIPK1-mediated regulated necrosis	24	1.74e-02	0.21200	0.39800	-2.16e-01	-0.334000	6.68e-02	4.58e-03
Regulation of necroptotic cell death	24	1.74e-02	0.21200	0.39800	-2.16e-01	-0.334000	6.68e-02	4.58e-03
Degradation of cysteine and homocysteine	10	1.53e-01	0.51100	0.39700	-3.46e-01	-0.194000	5.79e-02	2.89e-01
VxPx cargo-targeting to cilium	16	1.00e-01	0.44900	0.39700	3.05e-01	0.254000	3.48e-02	7.87e-02
Activation of G protein gated Potassium channels	10	1.95e-01	0.53900	0.39700	2.20e-01	0.330000	2.28e-01	7.09e-02
G protein gated Potassium channels	10	1.95e-01	0.53900	0.39700	2.20e-01	0.330000	2.28e-01	7.09e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	10	1.95e-01	0.53900	0.39700	2.20e-01	0.330000	2.28e-01	7.09e-02
mRNA 3’-end processing	30	1.43e-02	0.19600	0.39500	-2.54e-01	-0.302000	1.59e-02	4.18e-03
Cytosolic sulfonation of small molecules	10	2.25e-01	0.58200	0.39500	2.38e-01	0.315000	1.92e-01	8.47e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	1.33e-01	0.49100	0.39400	-3.22e-01	-0.227000	4.47e-02	1.57e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.10e-01	0.46300	0.39300	-2.23e-01	-0.324000	1.49e-01	3.58e-02
Cardiac conduction	40	1.73e-03	0.07500	0.39300	3.26e-01	0.220000	3.67e-04	1.61e-02
G beta:gamma signalling through PLC beta	11	1.75e-01	0.51400	0.39000	3.25e-01	0.216000	6.24e-02	2.16e-01
Presynaptic function of Kainate receptors	11	1.75e-01	0.51400	0.39000	3.25e-01	0.216000	6.24e-02	2.16e-01
Cell-cell junction organization	12	1.69e-01	0.51200	0.38800	2.27e-01	0.315000	1.73e-01	5.93e-02
VLDLR internalisation and degradation	11	2.22e-01	0.58000	0.38500	-2.99e-01	-0.242000	8.60e-02	1.64e-01
Post NMDA receptor activation events	36	2.09e-03	0.07500	0.38300	3.32e-01	0.190000	5.62e-04	4.88e-02
Homologous DNA Pairing and Strand Exchange	35	1.13e-02	0.17000	0.38200	-2.66e-01	-0.275000	6.58e-03	4.97e-03
Prostacyclin signalling through prostacyclin receptor	10	2.36e-01	0.59500	0.38100	2.21e-01	0.310000	2.26e-01	8.92e-02
Synthesis of PA	15	1.33e-01	0.49100	0.37600	2.99e-01	0.229000	4.52e-02	1.25e-01
Meiosis	39	3.51e-03	0.10400	0.37500	-2.09e-01	-0.311000	2.41e-02	7.85e-04
Downregulation of ERBB2 signaling	17	6.90e-02	0.38800	0.37400	-1.93e-01	-0.320000	1.69e-01	2.22e-02
Myogenesis	13	1.19e-04	0.03480	0.37200	2.19e-01	-0.300000	1.71e-01	6.10e-02
Diseases associated with O-glycosylation of proteins	17	1.03e-01	0.45400	0.37200	2.98e-01	0.221000	3.32e-02	1.14e-01
RNA Polymerase II Transcription Termination	38	9.89e-03	0.15600	0.37100	-2.52e-01	-0.272000	7.13e-03	3.72e-03
Netrin-1 signaling	24	1.66e-02	0.21200	0.37000	3.27e-01	0.173000	5.54e-03	1.43e-01
HDR through Single Strand Annealing (SSA)	33	1.93e-02	0.21900	0.36600	-2.41e-01	-0.275000	1.68e-02	6.23e-03
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	16	9.24e-02	0.43300	0.36600	3.12e-01	0.190000	3.06e-02	1.88e-01
Processing of Capped Intronless Pre-mRNA	23	5.38e-02	0.36100	0.36300	-2.16e-01	-0.291000	7.26e-02	1.58e-02
Leading Strand Synthesis	12	2.30e-01	0.58800	0.36100	-2.23e-01	-0.284000	1.81e-01	8.86e-02
Polymerase switching	12	2.30e-01	0.58800	0.36100	-2.23e-01	-0.284000	1.81e-01	8.86e-02
Citric acid cycle (TCA cycle)	18	1.29e-01	0.49100	0.36000	-2.52e-01	-0.257000	6.43e-02	5.92e-02
Hh mutants abrogate ligand secretion	45	5.59e-03	0.11500	0.35900	-2.70e-01	-0.237000	1.75e-03	5.91e-03
Stabilization of p53	46	5.63e-03	0.11500	0.35900	-2.49e-01	-0.258000	3.55e-03	2.48e-03
Activation of NMDA receptors and postsynaptic events	42	4.41e-03	0.11200	0.35800	2.94e-01	0.204000	9.91e-04	2.23e-02
Negative regulation of FGFR1 signaling	17	1.43e-01	0.49100	0.35700	-2.69e-01	-0.236000	5.52e-02	9.27e-02
Negative regulation of FGFR2 signaling	17	1.43e-01	0.49100	0.35700	-2.69e-01	-0.236000	5.52e-02	9.27e-02
Negative regulation of FGFR3 signaling	17	1.43e-01	0.49100	0.35700	-2.69e-01	-0.236000	5.52e-02	9.27e-02
Negative regulation of FGFR4 signaling	17	1.43e-01	0.49100	0.35700	-2.69e-01	-0.236000	5.52e-02	9.27e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	1.06e-01	0.45700	0.35600	-3.39e-01	-0.109000	6.32e-02	5.52e-01
Hh mutants are degraded by ERAD	44	8.49e-03	0.14500	0.35100	-2.57e-01	-0.239000	3.25e-03	6.09e-03
Inwardly rectifying K+ channels	11	2.59e-01	0.60300	0.35000	2.01e-01	0.286000	2.47e-01	1.00e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	2.23e-01	0.58100	0.34900	2.49e-01	0.245000	1.07e-01	1.12e-01
Class A/1 (Rhodopsin-like receptors)	40	1.36e-02	0.19000	0.34800	2.59e-01	0.232000	4.59e-03	1.14e-02
Collagen degradation	10	1.88e-02	0.21800	0.34500	-2.67e-02	0.344000	8.84e-01	5.94e-02
Neurexins and neuroligins	20	8.46e-02	0.42200	0.34500	2.87e-01	0.191000	2.65e-02	1.38e-01
Hedgehog ligand biogenesis	48	6.76e-03	0.13200	0.34500	-2.48e-01	-0.239000	2.94e-03	4.21e-03
Synthesis of IP3 and IP4 in the cytosol	16	6.05e-02	0.37600	0.34500	3.17e-01	0.134000	2.80e-02	3.53e-01
Erythropoietin activates RAS	10	2.33e-02	0.22800	0.34500	-1.34e-02	0.344000	9.42e-01	5.94e-02
Processive synthesis on the C-strand of the telomere	17	1.67e-01	0.51200	0.34400	-2.57e-01	-0.228000	6.64e-02	1.04e-01
Interleukin-20 family signaling	13	3.74e-02	0.29800	0.34300	7.01e-02	0.336000	6.62e-01	3.62e-02
Signaling by Erythropoietin	18	1.90e-02	0.21800	0.34200	9.32e-02	0.329000	4.94e-01	1.58e-02
Adrenaline,noradrenaline inhibits insulin secretion	12	1.52e-01	0.50900	0.33900	3.07e-01	0.144000	6.56e-02	3.86e-01
GPCR ligand binding	68	5.74e-04	0.05860	0.33900	2.04e-01	0.271000	3.77e-03	1.15e-04
Generation of second messenger molecules	12	1.20e-01	0.47100	0.33600	1.22e-01	0.313000	4.66e-01	6.06e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	23	9.26e-02	0.43300	0.33500	-2.12e-01	-0.260000	7.90e-02	3.10e-02
Purine salvage	10	3.51e-01	0.69300	0.33300	-2.63e-01	-0.204000	1.50e-01	2.64e-01
Gap junction trafficking and regulation	10	1.09e-01	0.46300	0.33200	3.22e-01	0.079900	7.77e-02	6.62e-01
Autodegradation of the E3 ubiquitin ligase COP1	41	1.95e-02	0.21900	0.33100	-2.31e-01	-0.237000	1.05e-02	8.68e-03
Regulation of TP53 Activity through Methylation	16	2.12e-01	0.56800	0.33000	-2.19e-01	-0.247000	1.30e-01	8.76e-02
Cell junction organization	21	7.86e-02	0.41000	0.32900	1.70e-01	0.281000	1.77e-01	2.56e-02
HDR through MMEJ (alt-NHEJ)	11	3.48e-01	0.69100	0.32700	-2.46e-01	-0.216000	1.58e-01	2.15e-01
Nucleotide catabolism	20	1.38e-01	0.49100	0.32700	-2.05e-01	-0.255000	1.13e-01	4.85e-02
Downregulation of ERBB2:ERBB3 signaling	10	3.77e-01	0.71100	0.32500	-2.53e-01	-0.204000	1.67e-01	2.65e-01
Removal of the Flap Intermediate	12	2.60e-01	0.60300	0.32400	-1.75e-01	-0.273000	2.95e-01	1.02e-01
Diseases of DNA repair	41	2.19e-02	0.22800	0.32300	-2.43e-01	-0.214000	7.26e-03	1.80e-02
ER Quality Control Compartment (ERQC)	18	1.87e-01	0.53400	0.32300	-2.42e-01	-0.214000	7.58e-02	1.16e-01
SARS-CoV-2 modulates host translation machinery	38	2.63e-02	0.23500	0.32100	-2.00e-01	-0.251000	3.33e-02	7.44e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	4.07e-01	0.71500	0.32000	-2.21e-01	-0.231000	2.26e-01	2.06e-01
Spry regulation of FGF signaling	15	2.52e-01	0.59800	0.32000	-2.42e-01	-0.209000	1.05e-01	1.62e-01
Ion transport by P-type ATPases	27	6.58e-02	0.37900	0.31900	2.60e-01	0.185000	1.97e-02	9.67e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	15	2.30e-01	0.58800	0.31900	-1.91e-01	-0.255000	2.02e-01	8.69e-02
Deposition of new CENPA-containing nucleosomes at the centromere	20	1.31e-01	0.49100	0.31500	-1.77e-01	-0.260000	1.72e-01	4.40e-02
Nucleosome assembly	20	1.31e-01	0.49100	0.31500	-1.77e-01	-0.260000	1.72e-01	4.40e-02
ER-Phagosome pathway	63	4.32e-03	0.11200	0.31300	-2.10e-01	-0.232000	3.92e-03	1.50e-03
LDL clearance	11	2.49e-01	0.59600	0.31300	-1.41e-01	-0.279000	4.18e-01	1.09e-01
G alpha (i) signalling events	81	9.18e-04	0.05960	0.31200	2.33e-01	0.208000	2.96e-04	1.25e-03
Caspase activation via extrinsic apoptotic signalling pathway	15	1.70e-01	0.51200	0.31200	-1.49e-01	-0.274000	3.18e-01	6.64e-02
Vif-mediated degradation of APOBEC3G	40	3.45e-02	0.28200	0.30900	-2.26e-01	-0.211000	1.35e-02	2.09e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	46	1.02e-02	0.15900	0.30700	-2.58e-01	-0.168000	2.53e-03	4.95e-02
Neurotransmitter receptors and postsynaptic signal transmission	72	1.24e-03	0.06580	0.30600	2.50e-01	0.177000	2.53e-04	9.58e-03
FOXO-mediated transcription of cell death genes	14	8.43e-02	0.42200	0.30600	8.35e-02	0.294000	5.89e-01	5.65e-02
Pre-NOTCH Processing in Golgi	15	6.32e-02	0.37900	0.30600	2.96e-01	0.076900	4.72e-02	6.06e-01
Defective CFTR causes cystic fibrosis	49	1.81e-02	0.21400	0.30600	-2.13e-01	-0.220000	1.00e-02	7.90e-03
Processing of DNA double-strand break ends	51	9.03e-03	0.14500	0.30500	-1.76e-01	-0.249000	2.97e-02	2.15e-03
Transport of the SLBP independent Mature mRNA	30	3.16e-02	0.26500	0.30400	-2.69e-01	-0.142000	1.08e-02	1.78e-01
Class B/2 (Secretin family receptors)	26	1.79e-02	0.21400	0.30300	9.92e-02	0.286000	3.82e-01	1.15e-02
Plasma lipoprotein clearance	21	1.47e-01	0.49800	0.30300	-1.76e-01	-0.247000	1.64e-01	5.03e-02
Peptide ligand-binding receptors	17	2.57e-01	0.60300	0.30200	2.17e-01	0.210000	1.22e-01	1.34e-01
Export of Viral Ribonucleoproteins from Nucleus	29	4.85e-02	0.34400	0.30100	-2.60e-01	-0.152000	1.54e-02	1.56e-01
Transport of the SLBP Dependant Mature mRNA	31	2.10e-02	0.22800	0.30100	-2.73e-01	-0.127000	8.60e-03	2.23e-01
TICAM1-dependent activation of IRF3/IRF7	12	2.11e-01	0.56800	0.30100	-2.75e-01	-0.121000	9.91e-02	4.67e-01
Homology Directed Repair	83	8.83e-04	0.05960	0.29900	-1.81e-01	-0.238000	4.53e-03	1.84e-04
Regulation of TP53 Activity through Phosphorylation	74	1.16e-03	0.06480	0.29800	-1.66e-01	-0.247000	1.35e-02	2.41e-04
Diseases associated with glycosaminoglycan metabolism	16	9.26e-02	0.43300	0.29800	2.81e-01	0.098500	5.16e-02	4.95e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	8.54e-02	0.42200	0.29800	2.50e-01	0.161000	2.72e-02	1.55e-01
Visual phototransduction	31	1.07e-02	0.16300	0.29800	2.80e-01	0.100000	6.95e-03	3.34e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	77	1.13e-03	0.06480	0.29800	-1.71e-01	-0.243000	9.51e-03	2.29e-04
Miscellaneous transport and binding events	13	1.31e-02	0.18600	0.29700	5.62e-02	-0.291000	7.26e-01	6.90e-02
G alpha (z) signalling events	22	7.92e-02	0.41000	0.29700	2.66e-01	0.132000	3.10e-02	2.85e-01
Chondroitin sulfate/dermatan sulfate metabolism	24	1.57e-01	0.51200	0.29700	2.11e-01	0.209000	7.40e-02	7.70e-02
NGF-stimulated transcription	25	9.01e-03	0.14500	0.29600	-2.90e-01	-0.060200	1.22e-02	6.02e-01
p53-Dependent G1 DNA Damage Response	53	1.73e-02	0.21200	0.29600	-2.06e-01	-0.212000	9.68e-03	7.56e-03
p53-Dependent G1/S DNA damage checkpoint	53	1.73e-02	0.21200	0.29600	-2.06e-01	-0.212000	9.68e-03	7.56e-03
Reproduction	43	1.62e-02	0.20900	0.29400	-1.53e-01	-0.251000	8.21e-02	4.45e-03
Nuclear Pore Complex (NPC) Disassembly	32	5.86e-02	0.37200	0.29300	-2.43e-01	-0.164000	1.74e-02	1.09e-01
Transport of Mature Transcript to Cytoplasm	55	1.28e-02	0.18600	0.29300	-2.28e-01	-0.184000	3.46e-03	1.86e-02
SUMOylation of immune response proteins	10	4.63e-01	0.73800	0.29200	2.21e-01	0.191000	2.26e-01	2.96e-01
Detoxification of Reactive Oxygen Species	22	1.46e-01	0.49400	0.29200	1.64e-01	0.242000	1.85e-01	4.99e-02
Interleukin-6 signaling	10	7.26e-02	0.39500	0.29000	-2.90e-01	0.007680	1.12e-01	9.66e-01
Regulation of HSF1-mediated heat shock response	63	8.50e-03	0.14500	0.29000	-2.21e-01	-0.188000	2.47e-03	1.01e-02
Retinoid metabolism and transport	10	2.60e-01	0.60300	0.28800	2.71e-01	0.100000	1.39e-01	5.83e-01
Recognition of DNA damage by PCNA-containing replication complex	26	7.15e-02	0.39200	0.28800	-1.36e-01	-0.253000	2.29e-01	2.55e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	39	5.75e-02	0.37200	0.28700	-2.14e-01	-0.191000	2.09e-02	3.87e-02
Transport of Mature mRNA Derived from an Intronless Transcript	37	6.71e-02	0.38200	0.28600	-2.14e-01	-0.190000	2.44e-02	4.53e-02
Cytochrome P450 - arranged by substrate type	14	3.08e-01	0.65200	0.28600	2.37e-01	0.160000	1.25e-01	2.99e-01
Ubiquitin-dependent degradation of Cyclin D	41	5.27e-02	0.35800	0.28600	-2.07e-01	-0.198000	2.21e-02	2.86e-02
RIP-mediated NFkB activation via ZBP1	13	3.76e-01	0.71100	0.28600	-1.80e-01	-0.222000	2.61e-01	1.67e-01
Translesion synthesis by POLK	15	2.07e-01	0.56200	0.28500	-1.29e-01	-0.255000	3.88e-01	8.80e-02
ZBP1(DAI) mediated induction of type I IFNs	16	3.17e-01	0.66200	0.28500	-1.92e-01	-0.210000	1.84e-01	1.46e-01
Sensory processing of sound	23	1.93e-01	0.53900	0.28400	1.92e-01	0.210000	1.11e-01	8.21e-02
Sensory processing of sound by inner hair cells of the cochlea	23	1.93e-01	0.53900	0.28400	1.92e-01	0.210000	1.11e-01	8.21e-02
COPII-mediated vesicle transport	47	3.33e-02	0.27400	0.28400	-1.85e-01	-0.215000	2.81e-02	1.08e-02
G2/M DNA damage checkpoint	51	1.58e-02	0.20500	0.28300	-1.61e-01	-0.233000	4.76e-02	3.98e-03
G beta:gamma signalling through CDC42	11	4.62e-01	0.73800	0.28300	1.94e-01	0.205000	2.65e-01	2.39e-01
Inactivation, recovery and regulation of the phototransduction cascade	16	4.26e-02	0.31700	0.28200	2.80e-01	0.035200	5.25e-02	8.08e-01
The phototransduction cascade	16	4.26e-02	0.31700	0.28200	2.80e-01	0.035200	5.25e-02	8.08e-01
Condensation of Prophase Chromosomes	12	1.56e-01	0.51200	0.28200	-7.20e-02	-0.272000	6.66e-01	1.03e-01
ISG15 antiviral mechanism	66	3.86e-03	0.10700	0.28100	-2.37e-01	-0.152000	9.01e-04	3.33e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	38	6.28e-02	0.37900	0.28100	-2.19e-01	-0.176000	1.98e-02	6.03e-02
Sensory Perception	61	4.12e-03	0.11200	0.28100	2.42e-01	0.142000	1.09e-03	5.55e-02
Antiviral mechanism by IFN-stimulated genes	72	2.07e-03	0.07500	0.28100	-2.38e-01	-0.148000	4.82e-04	3.00e-02
N-Glycan antennae elongation	11	3.95e-01	0.71200	0.28100	1.51e-01	0.236000	3.85e-01	1.75e-01
Signaling by CSF3 (G-CSF)	23	2.81e-02	0.24500	0.27900	-2.71e-01	-0.068300	2.46e-02	5.71e-01
Metabolism of non-coding RNA	45	2.15e-02	0.22800	0.27800	-2.37e-01	-0.145000	6.02e-03	9.29e-02
snRNP Assembly	45	2.15e-02	0.22800	0.27800	-2.37e-01	-0.145000	6.02e-03	9.29e-02
Collagen formation	18	1.11e-01	0.46300	0.27700	9.86e-02	0.259000	4.69e-01	5.70e-02
Regulation of IFNG signaling	12	1.55e-02	0.20300	0.27700	-1.09e-01	0.254000	5.13e-01	1.28e-01
VEGFR2 mediated cell proliferation	16	4.19e-02	0.31600	0.27700	2.75e-01	0.026600	5.67e-02	8.54e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	21	2.10e-01	0.56600	0.27600	2.23e-01	0.163000	7.72e-02	1.97e-01
Aggrephagy	19	2.80e-01	0.62300	0.27600	-1.91e-01	-0.199000	1.49e-01	1.33e-01
Cleavage of the damaged pyrimidine	14	3.93e-01	0.71200	0.27600	-1.99e-01	-0.191000	1.98e-01	2.16e-01
Depyrimidination	14	3.93e-01	0.71200	0.27600	-1.99e-01	-0.191000	1.98e-01	2.16e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	3.93e-01	0.71200	0.27600	-1.99e-01	-0.191000	1.98e-01	2.16e-01
Other interleukin signaling	12	4.40e-01	0.72700	0.27400	2.10e-01	0.177000	2.08e-01	2.89e-01
HCMV Early Events	48	2.63e-02	0.23500	0.27400	-2.25e-01	-0.157000	7.00e-03	6.09e-02
ABC transporter disorders	55	2.43e-02	0.23100	0.27400	-1.78e-01	-0.208000	2.28e-02	7.59e-03
RHO GTPases Activate ROCKs	13	3.71e-01	0.71100	0.27400	-2.26e-01	-0.155000	1.59e-01	3.32e-01
CD209 (DC-SIGN) signaling	15	1.40e-01	0.49100	0.27400	8.46e-02	0.260000	5.71e-01	8.12e-02
Beta-catenin phosphorylation cascade	15	2.88e-01	0.62700	0.27400	2.33e-01	0.143000	1.18e-01	3.39e-01
Carboxyterminal post-translational modifications of tubulin	19	2.78e-01	0.62100	0.27300	1.78e-01	0.207000	1.79e-01	1.18e-01
Nucleotide biosynthesis	12	3.97e-01	0.71200	0.27300	1.53e-01	0.226000	3.60e-01	1.75e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	33	1.06e-01	0.45700	0.27300	-1.74e-01	-0.210000	8.45e-02	3.67e-02
DNA Double-Strand Break Repair	108	7.12e-04	0.05860	0.27200	-1.72e-01	-0.210000	2.04e-03	1.70e-04
APC truncation mutants have impaired AXIN binding	12	4.13e-01	0.71700	0.27100	2.22e-01	0.156000	1.84e-01	3.48e-01
AXIN missense mutants destabilize the destruction complex	12	4.13e-01	0.71700	0.27100	2.22e-01	0.156000	1.84e-01	3.48e-01
Signaling by AMER1 mutants	12	4.13e-01	0.71700	0.27100	2.22e-01	0.156000	1.84e-01	3.48e-01
Signaling by APC mutants	12	4.13e-01	0.71700	0.27100	2.22e-01	0.156000	1.84e-01	3.48e-01
Signaling by AXIN mutants	12	4.13e-01	0.71700	0.27100	2.22e-01	0.156000	1.84e-01	3.48e-01
Truncations of AMER1 destabilize the destruction complex	12	4.13e-01	0.71700	0.27100	2.22e-01	0.156000	1.84e-01	3.48e-01
Sensory processing of sound by outer hair cells of the cochlea	14	4.05e-01	0.71500	0.27100	1.96e-01	0.188000	2.05e-01	2.24e-01
Phase I - Functionalization of compounds	29	1.15e-01	0.46500	0.27100	1.54e-01	0.223000	1.53e-01	3.74e-02
ADP signalling through P2Y purinoceptor 1	12	4.32e-01	0.72100	0.27000	2.16e-01	0.163000	1.96e-01	3.27e-01
GABA receptor activation	16	3.51e-01	0.69300	0.27000	2.03e-01	0.178000	1.59e-01	2.17e-01
Telomere Extension By Telomerase	18	3.12e-01	0.65400	0.27000	-1.82e-01	-0.200000	1.81e-01	1.43e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	26	1.35e-01	0.49100	0.27000	-2.26e-01	-0.148000	4.61e-02	1.92e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	26	1.35e-01	0.49100	0.27000	-2.26e-01	-0.148000	4.61e-02	1.92e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	43	6.32e-02	0.37900	0.27000	-1.84e-01	-0.198000	3.71e-02	2.50e-02
EGFR downregulation	20	5.74e-02	0.37200	0.26900	-6.74e-02	-0.261000	6.02e-01	4.36e-02
HSF1 activation	21	2.65e-01	0.61100	0.26800	-1.87e-01	-0.192000	1.38e-01	1.27e-01
Synthesis of very long-chain fatty acyl-CoAs	10	6.41e-02	0.37900	0.26800	-5.27e-02	0.263000	7.73e-01	1.50e-01
RUNX3 regulates p14-ARF	10	5.24e-01	0.77400	0.26800	-2.03e-01	-0.174000	2.66e-01	3.40e-01
RAC3 GTPase cycle	54	1.87e-03	0.07500	0.26700	9.12e-02	0.251000	2.47e-01	1.44e-03
Regulation of TP53 Degradation	33	8.26e-02	0.41800	0.26600	-1.44e-01	-0.224000	1.53e-01	2.61e-02
Regulation of TP53 Expression and Degradation	33	8.26e-02	0.41800	0.26600	-1.44e-01	-0.224000	1.53e-01	2.61e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	43	5.84e-02	0.37200	0.26600	-2.09e-01	-0.165000	1.79e-02	6.21e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	1.81e-01	0.52300	0.26500	-1.45e-01	-0.222000	2.30e-01	6.55e-02
Neuronal System	124	3.84e-04	0.05670	0.26500	2.04e-01	0.169000	9.22e-05	1.22e-03
Termination of translesion DNA synthesis	27	1.92e-01	0.53900	0.26400	-1.86e-01	-0.188000	9.54e-02	9.09e-02
Transmission across Chemical Synapses	91	3.29e-03	0.10100	0.26400	2.02e-01	0.169000	8.84e-04	5.31e-03
NEP/NS2 Interacts with the Cellular Export Machinery	28	8.64e-02	0.42200	0.26400	-2.34e-01	-0.122000	3.23e-02	2.65e-01
Lagging Strand Synthesis	17	2.74e-01	0.61700	0.26400	-1.39e-01	-0.224000	3.20e-01	1.10e-01
mRNA Splicing - Major Pathway	130	2.07e-04	0.04660	0.26400	-1.61e-01	-0.209000	1.64e-03	4.07e-05
Attenuation phase	19	3.14e-01	0.65700	0.26300	-1.90e-01	-0.182000	1.51e-01	1.69e-01
AKT phosphorylates targets in the cytosol	13	2.48e-01	0.59600	0.26300	-9.72e-02	-0.245000	5.44e-01	1.26e-01
STING mediated induction of host immune responses	10	2.99e-01	0.63700	0.26300	8.17e-02	0.250000	6.55e-01	1.71e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	1.63e-01	0.51200	0.26300	2.36e-01	0.116000	6.82e-02	3.69e-01
Neurodegenerative Diseases	20	1.63e-01	0.51200	0.26300	2.36e-01	0.116000	6.82e-02	3.69e-01
RUNX2 regulates osteoblast differentiation	12	1.61e-01	0.51200	0.26200	4.93e-02	0.258000	7.68e-01	1.23e-01
Thrombin signalling through proteinase activated receptors (PARs)	16	2.02e-01	0.55000	0.26200	2.41e-01	0.103000	9.58e-02	4.74e-01
Depolymerisation of the Nuclear Lamina	11	2.95e-01	0.63200	0.26000	2.45e-01	0.088800	1.60e-01	6.10e-01
Vpu mediated degradation of CD4	40	8.08e-02	0.41600	0.26000	-2.04e-01	-0.161000	2.59e-02	7.78e-02
Methylation	10	5.54e-01	0.78700	0.26000	-1.83e-01	-0.184000	3.17e-01	3.13e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	3.94e-01	0.71200	0.25900	-1.08e-01	-0.235000	5.55e-01	1.98e-01
alpha-linolenic acid (ALA) metabolism	10	3.94e-01	0.71200	0.25900	-1.08e-01	-0.235000	5.55e-01	1.98e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	49	5.64e-02	0.37200	0.25800	-1.75e-01	-0.190000	3.45e-02	2.17e-02
Processing of Capped Intron-Containing Pre-mRNA	177	3.41e-05	0.01330	0.25800	-1.72e-01	-0.192000	8.20e-05	1.21e-05
Insulin processing	15	3.11e-01	0.65400	0.25700	2.24e-01	0.127000	1.34e-01	3.95e-01
Resolution of Abasic Sites (AP sites)	32	1.57e-01	0.51200	0.25600	-1.71e-01	-0.190000	9.35e-02	6.35e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	72	1.45e-02	0.19800	0.25500	-1.63e-01	-0.195000	1.67e-02	4.22e-03
DARPP-32 events	18	8.89e-02	0.43300	0.25500	5.70e-02	0.248000	6.76e-01	6.84e-02
G alpha (q) signalling events	67	5.84e-03	0.11800	0.25400	2.22e-01	0.124000	1.70e-03	7.99e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	49	5.03e-02	0.35200	0.25300	-2.02e-01	-0.154000	1.48e-02	6.30e-02
Regulation of FZD by ubiquitination	12	4.17e-01	0.71800	0.25300	1.29e-01	0.218000	4.40e-01	1.92e-01
SCF(Skp2)-mediated degradation of p27/p21	49	5.81e-02	0.37200	0.25300	-1.94e-01	-0.162000	1.88e-02	5.07e-02
Antigen processing-Cross presentation	68	2.24e-02	0.22800	0.25300	-1.74e-01	-0.183000	1.32e-02	9.16e-03
G1/S DNA Damage Checkpoints	55	4.69e-02	0.33800	0.25200	-1.75e-01	-0.181000	2.47e-02	2.02e-02
COPI-mediated anterograde transport	65	2.73e-02	0.24000	0.25100	-1.72e-01	-0.184000	1.69e-02	1.06e-02
E3 ubiquitin ligases ubiquitinate target proteins	40	6.97e-02	0.39000	0.25100	-2.10e-01	-0.136000	2.15e-02	1.36e-01
Glucagon-type ligand receptors	12	4.23e-01	0.71800	0.25100	1.27e-01	0.216000	4.45e-01	1.96e-01
Interleukin-6 family signaling	13	6.09e-02	0.37600	0.25000	-2.49e-01	0.025800	1.20e-01	8.72e-01
Platelet calcium homeostasis	16	2.45e-01	0.59600	0.24900	2.27e-01	0.102000	1.16e-01	4.81e-01
PRC2 methylates histones and DNA	11	5.50e-01	0.78600	0.24800	-1.80e-01	-0.171000	3.01e-01	3.26e-01
mRNA decay by 3’ to 5’ exoribonuclease	14	2.74e-01	0.61700	0.24800	-9.45e-02	-0.229000	5.41e-01	1.38e-01
Signaling by Activin	11	3.26e-02	0.27100	0.24800	-1.94e-01	0.154000	2.66e-01	3.76e-01
ROS and RNS production in phagocytes	22	2.91e-01	0.62700	0.24700	1.57e-01	0.191000	2.02e-01	1.21e-01
CaM pathway	17	2.02e-01	0.55000	0.24700	2.29e-01	0.090900	1.02e-01	5.16e-01
Calmodulin induced events	17	2.02e-01	0.55000	0.24700	2.29e-01	0.090900	1.02e-01	5.16e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	5.56e-01	0.78700	0.24700	-1.75e-01	-0.174000	3.16e-01	3.18e-01
PCNA-Dependent Long Patch Base Excision Repair	18	2.91e-01	0.62700	0.24600	-1.26e-01	-0.212000	3.54e-01	1.20e-01
Regulation of ornithine decarboxylase (ODC)	40	1.18e-01	0.46600	0.24600	-1.65e-01	-0.182000	7.11e-02	4.66e-02
Degradation of GLI1 by the proteasome	48	6.48e-02	0.37900	0.24600	-1.95e-01	-0.150000	1.98e-02	7.31e-02
Ca-dependent events	18	1.92e-01	0.53900	0.24500	2.27e-01	0.092100	9.49e-02	4.99e-01
Bile acid and bile salt metabolism	13	2.73e-01	0.61700	0.24400	2.30e-01	0.080800	1.50e-01	6.14e-01
Molecules associated with elastic fibres	10	2.01e-01	0.55000	0.24300	-1.68e-02	-0.243000	9.27e-01	1.84e-01
Integrin signaling	14	1.67e-01	0.51200	0.24200	-4.75e-02	-0.237000	7.59e-01	1.24e-01
Platelet Aggregation (Plug Formation)	14	1.67e-01	0.51200	0.24200	-4.75e-02	-0.237000	7.59e-01	1.24e-01
Platelet homeostasis	44	1.03e-01	0.45400	0.24200	1.65e-01	0.177000	5.93e-02	4.19e-02
Integrin cell surface interactions	22	7.44e-02	0.40100	0.24200	2.35e-01	0.057100	5.68e-02	6.43e-01
Inactivation of CSF3 (G-CSF) signaling	18	5.42e-02	0.36200	0.24200	-2.41e-01	-0.012700	7.65e-02	9.26e-01
Base Excision Repair	39	1.37e-01	0.49100	0.24100	-1.73e-01	-0.168000	6.21e-02	6.92e-02
Vpr-mediated nuclear import of PICs	30	1.63e-01	0.51200	0.24100	-2.01e-01	-0.134000	5.72e-02	2.05e-01
MicroRNA (miRNA) biogenesis	18	3.97e-01	0.71200	0.24100	-1.63e-01	-0.178000	2.32e-01	1.92e-01
Signaling by FGFR3	24	2.19e-01	0.57400	0.24100	-2.04e-01	-0.127000	8.33e-02	2.81e-01
Signaling by FGFR4	24	2.19e-01	0.57400	0.24100	-2.04e-01	-0.127000	8.33e-02	2.81e-01
G-protein beta:gamma signalling	18	2.48e-01	0.59600	0.24100	2.17e-01	0.105000	1.12e-01	4.43e-01
Meiotic synapsis	22	2.35e-01	0.59400	0.24000	-1.22e-01	-0.207000	3.21e-01	9.30e-02
Ca2+ pathway	34	1.17e-01	0.46600	0.24000	2.04e-01	0.126000	3.98e-02	2.03e-01
Lysosome Vesicle Biogenesis	24	1.71e-01	0.51200	0.23900	2.13e-01	0.108000	7.07e-02	3.62e-01
mRNA Splicing	138	5.60e-04	0.05860	0.23900	-1.43e-01	-0.191000	3.86e-03	1.12e-04
DNA Damage Bypass	40	8.58e-02	0.42200	0.23900	-1.28e-01	-0.202000	1.63e-01	2.75e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	31	6.70e-02	0.38200	0.23800	8.83e-02	0.221000	3.95e-01	3.31e-02
PKMTs methylate histone lysines	23	2.42e-01	0.59600	0.23800	1.27e-01	0.202000	2.94e-01	9.41e-02
CTNNB1 S33 mutants aren’t phosphorylated	13	3.97e-01	0.71200	0.23800	2.11e-01	0.110000	1.88e-01	4.91e-01
CTNNB1 S37 mutants aren’t phosphorylated	13	3.97e-01	0.71200	0.23800	2.11e-01	0.110000	1.88e-01	4.91e-01
CTNNB1 S45 mutants aren’t phosphorylated	13	3.97e-01	0.71200	0.23800	2.11e-01	0.110000	1.88e-01	4.91e-01
CTNNB1 T41 mutants aren’t phosphorylated	13	3.97e-01	0.71200	0.23800	2.11e-01	0.110000	1.88e-01	4.91e-01
Signaling by CTNNB1 phospho-site mutants	13	3.97e-01	0.71200	0.23800	2.11e-01	0.110000	1.88e-01	4.91e-01
Signaling by GSK3beta mutants	13	3.97e-01	0.71200	0.23800	2.11e-01	0.110000	1.88e-01	4.91e-01
Uptake and actions of bacterial toxins	18	3.65e-01	0.70700	0.23700	1.93e-01	0.137000	1.56e-01	3.13e-01
mRNA decay by 5’ to 3’ exoribonuclease	14	3.83e-01	0.71200	0.23700	-2.08e-01	-0.113000	1.77e-01	4.64e-01
Cellular response to heat stress	76	2.27e-02	0.22800	0.23700	-1.77e-01	-0.157000	7.63e-03	1.80e-02
G beta:gamma signalling through PI3Kgamma	14	4.97e-01	0.75800	0.23700	1.77e-01	0.158000	2.52e-01	3.06e-01
ADP signalling through P2Y purinoceptor 12	11	5.82e-01	0.79800	0.23700	1.66e-01	0.169000	3.41e-01	3.31e-01
Translesion synthesis by REV1	14	2.91e-01	0.62700	0.23600	-8.47e-02	-0.221000	5.83e-01	1.53e-01
Transport of Ribonucleoproteins into the Host Nucleus	28	1.95e-01	0.54000	0.23600	-1.97e-01	-0.130000	7.13e-02	2.33e-01
Resolution of Sister Chromatid Cohesion	88	8.88e-03	0.14500	0.23600	-1.41e-01	-0.190000	2.29e-02	2.14e-03
O-linked glycosylation	36	1.04e-01	0.45600	0.23600	2.03e-01	0.121000	3.56e-02	2.10e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	41	1.36e-01	0.49100	0.23600	-1.69e-01	-0.164000	6.09e-02	6.98e-02
p53-Independent DNA Damage Response	41	1.36e-01	0.49100	0.23600	-1.69e-01	-0.164000	6.09e-02	6.98e-02
p53-Independent G1/S DNA damage checkpoint	41	1.36e-01	0.49100	0.23600	-1.69e-01	-0.164000	6.09e-02	6.98e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	3.11e-01	0.65400	0.23400	-1.27e-01	-0.197000	3.25e-01	1.28e-01
Negative regulation of NOTCH4 signaling	45	1.17e-01	0.46600	0.23200	-1.72e-01	-0.156000	4.67e-02	7.00e-02
Triglyceride catabolism	11	5.62e-01	0.78700	0.23200	1.87e-01	0.137000	2.83e-01	4.30e-01
Interactions of Vpr with host cellular proteins	31	1.79e-01	0.51900	0.23100	-1.92e-01	-0.128000	6.39e-02	2.18e-01
Chromosome Maintenance	71	2.70e-02	0.23900	0.23000	-1.38e-01	-0.185000	4.51e-02	7.28e-03
NOD1/2 Signaling Pathway	22	7.89e-02	0.41000	0.23000	-4.51e-02	-0.226000	7.15e-01	6.72e-02
Inhibition of DNA recombination at telomere	18	4.06e-01	0.71500	0.23000	-1.40e-01	-0.182000	3.04e-01	1.81e-01
Nuclear Events (kinase and transcription factor activation)	42	2.61e-02	0.23500	0.22900	-2.16e-01	-0.077100	1.56e-02	3.88e-01
Viral Messenger RNA Synthesis	39	1.62e-01	0.51200	0.22900	-1.71e-01	-0.153000	6.51e-02	9.87e-02
Signaling by FGFR2	47	7.85e-02	0.41000	0.22900	-1.90e-01	-0.128000	2.42e-02	1.29e-01
DNA Double Strand Break Response	34	1.73e-01	0.51400	0.22900	-1.34e-01	-0.186000	1.76e-01	6.13e-02
Degradation of DVL	45	1.26e-01	0.48900	0.22900	-1.56e-01	-0.167000	7.02e-02	5.25e-02
Complex I biogenesis	38	1.75e-01	0.51400	0.22900	-1.65e-01	-0.158000	7.86e-02	9.15e-02
Heparan sulfate/heparin (HS-GAG) metabolism	22	2.89e-01	0.62700	0.22900	1.93e-01	0.122000	1.17e-01	3.20e-01
G2/M Checkpoints	106	7.99e-03	0.14400	0.22800	-1.53e-01	-0.169000	6.72e-03	2.77e-03
NS1 Mediated Effects on Host Pathways	36	1.90e-01	0.53700	0.22700	-1.71e-01	-0.150000	7.65e-02	1.19e-01
Degradation of GLI2 by the proteasome	47	1.16e-01	0.46500	0.22700	-1.70e-01	-0.151000	4.44e-02	7.35e-02
GLI3 is processed to GLI3R by the proteasome	47	1.16e-01	0.46500	0.22700	-1.70e-01	-0.151000	4.44e-02	7.35e-02
Formation of the ternary complex, and subsequently, the 43S complex	39	2.60e-02	0.23500	0.22700	-6.55e-02	-0.217000	4.80e-01	1.91e-02
Signaling by KIT in disease	16	1.27e-01	0.48900	0.22600	2.53e-02	0.225000	8.61e-01	1.20e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	1.27e-01	0.48900	0.22600	2.53e-02	0.225000	8.61e-01	1.20e-01
COPI-dependent Golgi-to-ER retrograde traffic	62	5.20e-02	0.35600	0.22600	-1.78e-01	-0.139000	1.56e-02	5.94e-02
Regulation of pyruvate dehydrogenase (PDH) complex	10	2.18e-01	0.57400	0.22500	-5.70e-04	0.225000	9.98e-01	2.18e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	74	3.52e-02	0.28400	0.22500	-1.71e-01	-0.146000	1.13e-02	3.03e-02
Constitutive Signaling by AKT1 E17K in Cancer	23	2.41e-01	0.59600	0.22400	-1.06e-01	-0.198000	3.78e-01	1.01e-01
Zinc transporters	11	3.94e-01	0.71200	0.22400	-2.12e-01	-0.073500	2.24e-01	6.73e-01
ER to Golgi Anterograde Transport	99	1.30e-02	0.18600	0.22300	-1.50e-01	-0.165000	9.98e-03	4.62e-03
Extension of Telomeres	40	1.72e-01	0.51400	0.22300	-1.50e-01	-0.165000	1.00e-01	7.17e-02
PLC beta mediated events	24	2.32e-02	0.22800	0.22300	2.23e-01	-0.008600	5.92e-02	9.42e-01
Metabolism of fat-soluble vitamins	12	3.63e-01	0.70500	0.22100	2.10e-01	0.070400	2.08e-01	6.73e-01
Recycling pathway of L1	15	2.43e-01	0.59600	0.22100	2.13e-01	0.057900	1.52e-01	6.98e-01
Nuclear import of Rev protein	29	1.31e-01	0.49100	0.22100	-2.02e-01	-0.088200	5.96e-02	4.11e-01
RAC2 GTPase cycle	52	3.23e-02	0.26900	0.22100	9.40e-02	0.199000	2.42e-01	1.29e-02
Nicotinamide salvaging	10	5.15e-01	0.77300	0.22000	9.39e-02	0.199000	6.07e-01	2.75e-01
Sema4D induced cell migration and growth-cone collapse	11	1.39e-01	0.49100	0.22000	-2.17e-01	0.036700	2.13e-01	8.33e-01
BBSome-mediated cargo-targeting to cilium	16	4.63e-01	0.73800	0.22000	-1.28e-01	-0.179000	3.76e-01	2.15e-01
Telomere C-strand (Lagging Strand) Synthesis	27	3.20e-01	0.66400	0.21900	-1.57e-01	-0.154000	1.59e-01	1.67e-01
Separation of Sister Chromatids	136	2.72e-03	0.08590	0.21900	-1.40e-01	-0.169000	5.03e-03	7.02e-04
Mitotic Prometaphase	147	1.62e-03	0.07500	0.21900	-1.37e-01	-0.170000	4.24e-03	3.83e-04
tRNA processing in the nucleus	52	1.10e-01	0.46300	0.21900	-1.63e-01	-0.146000	4.25e-02	6.90e-02
DAG and IP3 signaling	23	1.09e-01	0.46300	0.21900	2.12e-01	0.052100	7.82e-02	6.65e-01
Translation initiation complex formation	45	3.52e-02	0.28400	0.21900	-7.95e-02	-0.204000	3.57e-01	1.82e-02
Activation of GABAB receptors	15	5.23e-01	0.77400	0.21800	1.67e-01	0.141000	2.64e-01	3.45e-01
GABA B receptor activation	15	5.23e-01	0.77400	0.21800	1.67e-01	0.141000	2.64e-01	3.45e-01
Glutamate Neurotransmitter Release Cycle	10	9.22e-02	0.43300	0.21800	-1.27e-01	0.177000	4.85e-01	3.33e-01
Respiratory electron transport	73	4.53e-02	0.33300	0.21800	-1.64e-01	-0.143000	1.53e-02	3.48e-02
SUMOylation of ubiquitinylation proteins	35	2.29e-01	0.58800	0.21800	-1.63e-01	-0.144000	9.57e-02	1.40e-01
Oncogenic MAPK signaling	54	2.94e-02	0.25100	0.21800	1.98e-01	0.091100	1.22e-02	2.48e-01
Downstream signaling of activated FGFR1	11	2.45e-01	0.59600	0.21700	-2.17e-01	-0.015100	2.13e-01	9.31e-01
Downstream signaling of activated FGFR2	11	2.45e-01	0.59600	0.21700	-2.17e-01	-0.015100	2.13e-01	9.31e-01
Downstream signaling of activated FGFR3	11	2.45e-01	0.59600	0.21700	-2.17e-01	-0.015100	2.13e-01	9.31e-01
Downstream signaling of activated FGFR4	11	2.45e-01	0.59600	0.21700	-2.17e-01	-0.015100	2.13e-01	9.31e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	43	1.58e-01	0.51200	0.21700	-1.67e-01	-0.140000	5.91e-02	1.14e-01
MAPK targets/ Nuclear events mediated by MAP kinases	22	1.69e-01	0.51200	0.21700	-2.06e-01	-0.069600	9.49e-02	5.72e-01
Interleukin-35 Signalling	11	5.17e-01	0.77300	0.21700	9.87e-02	0.193000	5.71e-01	2.68e-01
Regulation of RUNX1 Expression and Activity	14	5.23e-01	0.77400	0.21600	-1.26e-01	-0.176000	4.13e-01	2.55e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	5.06e-01	0.76600	0.21600	-1.38e-01	-0.166000	3.38e-01	2.51e-01
Base-Excision Repair, AP Site Formation	16	3.89e-01	0.71200	0.21600	-1.92e-01	-0.099200	1.85e-01	4.92e-01
Signaling by Retinoic Acid	17	2.82e-01	0.62400	0.21500	7.48e-02	0.201000	5.94e-01	1.51e-01
Hyaluronan metabolism	10	2.94e-01	0.63200	0.21500	-1.76e-02	-0.214000	9.23e-01	2.41e-01
Metalloprotease DUBs	16	5.25e-01	0.77400	0.21400	-1.54e-01	-0.149000	2.88e-01	3.01e-01
RAF activation	28	3.25e-01	0.66800	0.21300	1.45e-01	0.156000	1.84e-01	1.53e-01
Heme signaling	25	3.68e-01	0.71000	0.21300	1.46e-01	0.155000	2.07e-01	1.79e-01
NIK–>noncanonical NF-kB signaling	46	1.63e-01	0.51200	0.21200	-1.55e-01	-0.145000	6.94e-02	9.02e-02
Telomere Maintenance	53	1.13e-01	0.46300	0.21100	-1.33e-01	-0.165000	9.47e-02	3.85e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	5.34e-01	0.77400	0.21100	-1.05e-01	-0.183000	5.30e-01	2.71e-01
Neurotransmitter release cycle	17	8.48e-02	0.42200	0.21100	-1.35e-02	0.210000	9.23e-01	1.34e-01
Defective pyroptosis	10	6.67e-01	0.85000	0.21100	-1.35e-01	-0.162000	4.61e-01	3.75e-01
TBC/RABGAPs	39	1.57e-01	0.51200	0.21000	-1.13e-01	-0.177000	2.21e-01	5.56e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	33	2.37e-01	0.59500	0.21000	-1.22e-01	-0.171000	2.25e-01	8.96e-02
Purine ribonucleoside monophosphate biosynthesis	10	5.53e-01	0.78700	0.21000	9.09e-02	0.189000	6.19e-01	3.00e-01
RHO GTPases Activate NADPH Oxidases	14	1.66e-01	0.51200	0.21000	2.10e-01	0.003920	1.75e-01	9.80e-01
Signaling by PDGFR in disease	15	1.16e-01	0.46500	0.20800	-1.56e-02	0.208000	9.17e-01	1.64e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	16	4.70e-01	0.73800	0.20800	-1.10e-01	-0.176000	4.45e-01	2.22e-01
Metabolism of folate and pterines	11	6.58e-01	0.84600	0.20800	-1.52e-01	-0.142000	3.83e-01	4.16e-01
SARS-CoV-2-host interactions	142	4.76e-03	0.11200	0.20800	-1.53e-01	-0.140000	1.71e-03	4.06e-03
Processive synthesis on the lagging strand	13	4.60e-01	0.73800	0.20700	-8.67e-02	-0.188000	5.88e-01	2.40e-01
Muscle contraction	63	2.18e-02	0.22800	0.20700	1.89e-01	0.084400	9.47e-03	2.47e-01
Cell Cycle Checkpoints	208	3.88e-04	0.05670	0.20700	-1.36e-01	-0.156000	7.77e-04	1.12e-04
Translocation of SLC2A4 (GLUT4) to the plasma membrane	44	5.11e-02	0.35400	0.20700	1.93e-01	0.074100	2.66e-02	3.95e-01
HATs acetylate histones	53	1.32e-01	0.49100	0.20700	-1.57e-01	-0.135000	4.91e-02	9.02e-02
Polymerase switching on the C-strand of the telomere	20	4.71e-01	0.73800	0.20600	-1.39e-01	-0.152000	2.82e-01	2.39e-01
Opioid Signalling	49	1.14e-01	0.46300	0.20600	1.72e-01	0.114000	3.75e-02	1.70e-01
RHO GTPases Activate Formins	97	1.52e-02	0.20200	0.20600	-1.16e-01	-0.170000	4.92e-02	3.84e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	31	2.75e-01	0.61700	0.20600	-1.20e-01	-0.167000	2.46e-01	1.08e-01
Regulation of innate immune responses to cytosolic DNA	11	4.86e-01	0.74900	0.20600	-1.91e-01	-0.075600	2.72e-01	6.64e-01
Infection with Mycobacterium tuberculosis	20	4.73e-01	0.73800	0.20600	-1.51e-01	-0.140000	2.42e-01	2.80e-01
HSF1-dependent transactivation	25	3.87e-01	0.71200	0.20600	-1.35e-01	-0.155000	2.43e-01	1.79e-01
Deadenylation of mRNA	22	7.18e-02	0.39200	0.20600	-2.05e-01	-0.008000	9.55e-02	9.48e-01
SUMOylation of RNA binding proteins	40	1.65e-01	0.51200	0.20400	-1.73e-01	-0.108000	5.92e-02	2.37e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	79	3.84e-02	0.29800	0.20400	-1.17e-01	-0.167000	7.23e-02	1.07e-02
Amplification of signal from the kinetochores	79	3.84e-02	0.29800	0.20400	-1.17e-01	-0.167000	7.23e-02	1.07e-02
Transcriptional regulation by small RNAs	41	1.66e-01	0.51200	0.20300	-1.71e-01	-0.111000	5.91e-02	2.20e-01
EML4 and NUDC in mitotic spindle formation	83	3.83e-02	0.29800	0.20300	-1.22e-01	-0.162000	5.57e-02	1.08e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	46	7.05e-02	0.39100	0.20300	-8.35e-02	-0.185000	3.28e-01	3.04e-02
Host Interactions of HIV factors	100	8.75e-03	0.14500	0.20300	-1.76e-01	-0.101000	2.47e-03	8.16e-02
Thromboxane signalling through TP receptor	11	5.77e-01	0.79500	0.20300	1.78e-01	0.096700	3.07e-01	5.79e-01
Deadenylation-dependent mRNA decay	50	9.11e-02	0.43300	0.20200	-1.76e-01	-0.099700	3.18e-02	2.23e-01
Calnexin/calreticulin cycle	23	4.25e-01	0.71800	0.20200	-1.29e-01	-0.155000	2.85e-01	1.97e-01
Disorders of Developmental Biology	10	4.42e-01	0.72700	0.20200	4.89e-02	0.196000	7.89e-01	2.84e-01
Disorders of Nervous System Development	10	4.42e-01	0.72700	0.20200	4.89e-02	0.196000	7.89e-01	2.84e-01
Loss of function of MECP2 in Rett syndrome	10	4.42e-01	0.72700	0.20200	4.89e-02	0.196000	7.89e-01	2.84e-01
Pervasive developmental disorders	10	4.42e-01	0.72700	0.20200	4.89e-02	0.196000	7.89e-01	2.84e-01
FLT3 signaling in disease	23	2.88e-01	0.62700	0.20200	-1.82e-01	-0.088100	1.32e-01	4.65e-01
FGFR2 alternative splicing	22	3.95e-01	0.71200	0.20100	-1.68e-01	-0.111000	1.74e-01	3.66e-01
Kinesins	31	3.32e-01	0.67700	0.20100	-1.44e-01	-0.140000	1.65e-01	1.77e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	37	1.58e-01	0.51200	0.20100	-1.77e-01	-0.094500	6.20e-02	3.20e-01
Golgi-to-ER retrograde transport	90	4.00e-02	0.30600	0.20100	-1.51e-01	-0.133000	1.37e-02	3.00e-02
Signaling by GPCR	187	1.46e-03	0.07410	0.20000	1.35e-01	0.148000	1.50e-03	5.27e-04
VEGFR2 mediated vascular permeability	21	3.95e-01	0.71200	0.20000	1.71e-01	0.105000	1.76e-01	4.05e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	4.28e-01	0.71900	0.20000	-8.20e-02	-0.183000	5.83e-01	2.21e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	5.90e-01	0.80200	0.20000	-1.06e-01	-0.170000	5.26e-01	3.08e-01
Interleukin-1 signaling	72	5.91e-02	0.37200	0.20000	-1.17e-01	-0.162000	8.68e-02	1.74e-02
Pre-NOTCH Expression and Processing	41	6.96e-03	0.13300	0.20000	2.00e-01	-0.001610	2.68e-02	9.86e-01
Mitotic Prophase	70	8.64e-02	0.42200	0.20000	-1.38e-01	-0.145000	4.68e-02	3.63e-02
SUMOylation of SUMOylation proteins	30	3.23e-01	0.66700	0.20000	-1.58e-01	-0.122000	1.35e-01	2.46e-01
Diseases associated with N-glycosylation of proteins	18	4.31e-01	0.72100	0.20000	-9.90e-02	-0.173000	4.67e-01	2.03e-01
Interactions of Rev with host cellular proteins	32	1.25e-01	0.48900	0.19900	-1.87e-01	-0.068200	6.68e-02	5.05e-01
TRAF3-dependent IRF activation pathway	14	3.33e-01	0.67700	0.19900	4.95e-02	0.193000	7.48e-01	2.11e-01
Interferon Signaling	130	2.46e-03	0.08000	0.19900	-1.73e-01	-0.097500	6.84e-04	5.59e-02
MAPK6/MAPK4 signaling	63	1.10e-01	0.46300	0.19800	-1.50e-01	-0.129000	3.98e-02	7.79e-02
Synthesis of glycosylphosphatidylinositol (GPI)	14	5.75e-01	0.79500	0.19700	-1.12e-01	-0.162000	4.67e-01	2.93e-01
Signaling by FGFR2 IIIa TM	15	5.95e-01	0.80300	0.19600	-1.48e-01	-0.129000	3.20e-01	3.87e-01
Signaling by NODAL	11	1.59e-01	0.51200	0.19600	-6.56e-02	0.185000	7.07e-01	2.88e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	5.00e-01	0.76000	0.19600	1.84e-01	0.066900	2.90e-01	7.01e-01
Post-translational protein phosphorylation	32	3.21e-01	0.66500	0.19600	1.53e-01	0.123000	1.36e-01	2.28e-01
Signaling by BRAF and RAF1 fusions	41	1.70e-01	0.51200	0.19600	1.68e-01	0.101000	6.28e-02	2.65e-01
Integration of energy metabolism	52	4.33e-02	0.32000	0.19600	1.83e-01	0.070100	2.27e-02	3.82e-01
Signaling by SCF-KIT	31	3.53e-01	0.69300	0.19600	1.35e-01	0.141000	1.93e-01	1.73e-01
FGFR2 mutant receptor activation	16	5.81e-01	0.79800	0.19500	-1.46e-01	-0.129000	3.12e-01	3.71e-01
Signaling by FGFR	50	1.26e-01	0.48900	0.19500	-1.65e-01	-0.103000	4.32e-02	2.09e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	33	3.31e-01	0.67700	0.19400	1.30e-01	0.144000	1.96e-01	1.52e-01
Interferon alpha/beta signaling	46	5.94e-02	0.37200	0.19400	-1.82e-01	-0.066400	3.26e-02	4.36e-01
Downregulation of TGF-beta receptor signaling	25	3.30e-01	0.67600	0.19400	9.54e-02	0.169000	4.10e-01	1.44e-01
Apoptotic factor-mediated response	14	7.01e-02	0.39000	0.19400	-1.20e-01	0.152000	4.37e-01	3.25e-01
XBP1(S) activates chaperone genes	39	2.80e-01	0.62300	0.19300	-1.38e-01	-0.135000	1.36e-01	1.45e-01
TNF signaling	35	2.94e-01	0.63200	0.19300	-1.19e-01	-0.152000	2.23e-01	1.20e-01
G-protein mediated events	27	2.42e-02	0.23100	0.19300	1.90e-01	-0.032900	8.78e-02	7.68e-01
Signaling by cytosolic FGFR1 fusion mutants	16	1.39e-01	0.49100	0.19200	-1.53e-02	0.192000	9.16e-01	1.84e-01
ABC-family proteins mediated transport	69	9.39e-02	0.43600	0.19200	-1.20e-01	-0.151000	8.64e-02	3.09e-02
Drug ADME	25	4.46e-01	0.73100	0.19200	1.36e-01	0.136000	2.40e-01	2.41e-01
Ribosomal scanning and start codon recognition	45	7.30e-02	0.39500	0.19200	-6.81e-02	-0.179000	4.30e-01	3.78e-02
GPCR downstream signalling	170	4.57e-03	0.11200	0.19100	1.38e-01	0.133000	2.05e-03	2.91e-03
Regulation of IFNA/IFNB signaling	11	1.28e-01	0.48900	0.19100	-1.43e-01	0.127000	4.12e-01	4.65e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	38	1.69e-01	0.51200	0.19100	1.70e-01	0.086900	6.93e-02	3.54e-01
UCH proteinases	69	1.11e-01	0.46300	0.19100	-1.37e-01	-0.133000	4.89e-02	5.66e-02
RUNX2 regulates bone development	16	2.37e-01	0.59500	0.19100	2.43e-02	0.189000	8.66e-01	1.90e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	5.98e-01	0.80300	0.19100	-1.57e-01	-0.109000	3.11e-01	4.82e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	5.98e-01	0.80300	0.19100	-1.57e-01	-0.109000	3.11e-01	4.82e-01
Glycogen metabolism	17	4.50e-01	0.73200	0.19000	-8.54e-02	-0.170000	5.42e-01	2.25e-01
Metabolism of polyamines	44	1.58e-01	0.51200	0.19000	-1.65e-01	-0.095000	5.89e-02	2.76e-01
AURKA Activation by TPX2	55	1.56e-01	0.51200	0.19000	-1.17e-01	-0.149000	1.32e-01	5.56e-02
Regulation of Apoptosis	42	2.50e-01	0.59600	0.18900	-1.47e-01	-0.119000	9.94e-02	1.82e-01
tRNA processing	86	6.37e-02	0.37900	0.18900	-1.22e-01	-0.144000	5.20e-02	2.12e-02
Nonhomologous End-Joining (NHEJ)	27	3.94e-01	0.71200	0.18800	-1.12e-01	-0.152000	3.15e-01	1.73e-01
Autodegradation of Cdh1 by Cdh1:APC/C	50	2.14e-01	0.57200	0.18800	-1.34e-01	-0.131000	1.01e-01	1.09e-01
Oncogene Induced Senescence	27	3.57e-01	0.70100	0.18700	-9.92e-02	-0.159000	3.72e-01	1.54e-01
Cholesterol biosynthesis	20	5.31e-01	0.77400	0.18700	-1.43e-01	-0.121000	2.70e-01	3.50e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	58	1.70e-01	0.51200	0.18700	-1.30e-01	-0.134000	8.62e-02	7.85e-02
Regulation of RUNX3 expression and activity	46	2.32e-01	0.58900	0.18700	-1.19e-01	-0.144000	1.62e-01	9.21e-02
PI3K/AKT Signaling in Cancer	51	1.42e-01	0.49100	0.18600	-9.67e-02	-0.159000	2.33e-01	5.05e-02
Signaling by ALK fusions and activated point mutants	42	9.68e-02	0.44100	0.18500	-1.74e-01	-0.063200	5.19e-02	4.79e-01
Signaling by ALK in cancer	42	9.68e-02	0.44100	0.18500	-1.74e-01	-0.063200	5.19e-02	4.79e-01
RNA Polymerase II Pre-transcription Events	61	1.62e-01	0.51200	0.18400	-1.36e-01	-0.123000	6.57e-02	9.67e-02
Sema4D in semaphorin signaling	13	2.66e-01	0.61200	0.18400	-1.84e-01	0.000838	2.51e-01	9.96e-01
APC/C:Cdc20 mediated degradation of Securin	51	2.18e-01	0.57400	0.18400	-1.37e-01	-0.123000	9.18e-02	1.30e-01
Rev-mediated nuclear export of HIV RNA	31	1.41e-01	0.49100	0.18300	-1.76e-01	-0.050200	8.94e-02	6.29e-01
CDC42 GTPase cycle	88	5.73e-02	0.37200	0.18300	1.09e-01	0.148000	7.92e-02	1.69e-02
Regulation of TNFR1 signaling	30	3.32e-01	0.67700	0.18300	-9.63e-02	-0.156000	3.62e-01	1.41e-01
Dectin-1 mediated noncanonical NF-kB signaling	47	2.48e-01	0.59600	0.18300	-1.36e-01	-0.122000	1.07e-01	1.47e-01
Gene Silencing by RNA	56	1.14e-01	0.46300	0.18300	-1.59e-01	-0.091000	4.05e-02	2.40e-01
DNA Damage Recognition in GG-NER	35	3.59e-01	0.70200	0.18300	-1.30e-01	-0.129000	1.85e-01	1.88e-01
Cross-presentation of soluble exogenous antigens (endosomes)	35	3.60e-01	0.70200	0.18300	-1.30e-01	-0.128000	1.83e-01	1.91e-01
RAC1 GTPase cycle	99	3.85e-02	0.29800	0.18300	1.06e-01	0.149000	6.97e-02	1.07e-02
Activation of NF-kappaB in B cells	53	1.62e-01	0.51200	0.18300	-1.52e-01	-0.102000	5.66e-02	2.01e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	57	1.88e-01	0.53400	0.18300	-1.34e-01	-0.124000	8.02e-02	1.06e-01
SCF-beta-TrCP mediated degradation of Emi1	44	2.52e-01	0.59800	0.18200	-1.44e-01	-0.111000	9.80e-02	2.03e-01
Formation of Incision Complex in GG-NER	35	2.96e-01	0.63300	0.18200	1.52e-01	0.100000	1.20e-01	3.06e-01
Arachidonic acid metabolism	19	5.16e-01	0.77300	0.18200	9.99e-02	0.152000	4.51e-01	2.51e-01
Defective Intrinsic Pathway for Apoptosis	23	2.31e-01	0.58900	0.18200	1.76e-01	0.047700	1.45e-01	6.92e-01
Regulation of PLK1 Activity at G2/M Transition	67	1.33e-01	0.49100	0.18200	-1.16e-01	-0.140000	1.02e-01	4.73e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	59	1.82e-01	0.52300	0.18100	-1.24e-01	-0.132000	9.98e-02	7.90e-02
Translation	228	1.03e-03	0.06320	0.18100	-1.43e-01	-0.111000	2.22e-04	4.14e-03
Pausing and recovery of Tat-mediated HIV elongation	22	3.86e-01	0.71200	0.18100	-7.91e-02	-0.162000	5.21e-01	1.88e-01
Tat-mediated HIV elongation arrest and recovery	22	3.86e-01	0.71200	0.18100	-7.91e-02	-0.162000	5.21e-01	1.88e-01
Disorders of transmembrane transporters	103	4.94e-02	0.34800	0.18000	-1.16e-01	-0.138000	4.34e-02	1.59e-02
Regulation of signaling by CBL	13	1.87e-01	0.53400	0.18000	-1.75e-01	0.042900	2.76e-01	7.89e-01
RHOQ GTPase cycle	36	3.61e-01	0.70400	0.18000	1.26e-01	0.128000	1.93e-01	1.83e-01
N-glycan antennae elongation in the medial/trans-Golgi	18	5.62e-01	0.78700	0.17900	1.46e-01	0.103000	2.83e-01	4.48e-01
Regulated Necrosis	41	2.70e-01	0.61600	0.17900	-1.03e-01	-0.146000	2.54e-01	1.06e-01
Triglyceride metabolism	15	5.85e-01	0.79900	0.17700	1.52e-01	0.090500	3.07e-01	5.44e-01
Signaling by FGFR1	27	3.43e-01	0.68300	0.17700	-1.57e-01	-0.080800	1.58e-01	4.68e-01
Pyruvate metabolism	18	1.63e-01	0.51200	0.17600	-1.06e-02	0.176000	9.38e-01	1.97e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	56	2.19e-01	0.57500	0.17500	-1.30e-01	-0.118000	9.36e-02	1.29e-01
Class I peroxisomal membrane protein import	17	5.54e-01	0.78700	0.17500	-8.96e-02	-0.150000	5.23e-01	2.83e-01
M Phase	273	7.25e-04	0.05860	0.17500	-1.17e-01	-0.130000	9.30e-04	2.48e-04
Translesion synthesis by POLI	15	4.20e-01	0.71800	0.17500	-4.73e-02	-0.168000	7.51e-01	2.59e-01
Metabolism of RNA	509	1.01e-06	0.00118	0.17500	-1.08e-01	-0.137000	3.94e-05	1.78e-07
Metabolism of nitric oxide: NOS3 activation and regulation	12	5.67e-01	0.79000	0.17400	1.62e-01	0.064000	3.30e-01	7.01e-01
Signaling by EGFR in Cancer	16	6.41e-01	0.83200	0.17400	-1.09e-01	-0.135000	4.49e-01	3.51e-01
Mitotic Spindle Checkpoint	91	6.85e-02	0.38700	0.17300	-1.01e-01	-0.141000	9.67e-02	2.06e-02
Anchoring of the basal body to the plasma membrane	72	1.01e-01	0.44900	0.17300	-9.35e-02	-0.146000	1.71e-01	3.30e-02
Vitamin B5 (pantothenate) metabolism	11	4.38e-01	0.72700	0.17300	-1.95e-02	-0.171000	9.11e-01	3.25e-01
Synthesis of bile acids and bile salts	12	3.73e-01	0.71100	0.17200	1.72e-01	0.009320	3.02e-01	9.55e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	4.95e-01	0.75800	0.17200	-1.25e-01	-0.119000	2.63e-01	2.86e-01
RAS processing	13	5.97e-01	0.80300	0.17200	7.40e-02	0.155000	6.44e-01	3.34e-01
Diseases of carbohydrate metabolism	23	2.53e-01	0.60000	0.17100	3.99e-02	0.167000	7.41e-01	1.67e-01
Regulation of expression of SLITs and ROBOs	118	5.11e-02	0.35400	0.17000	-1.25e-01	-0.115000	1.95e-02	3.18e-02
Non-integrin membrane-ECM interactions	11	6.68e-01	0.85100	0.17000	1.51e-01	0.077500	3.87e-01	6.56e-01
TAK1-dependent IKK and NF-kappa-B activation	17	4.67e-01	0.73800	0.16900	-6.13e-02	-0.158000	6.62e-01	2.61e-01
activated TAK1 mediates p38 MAPK activation	12	3.24e-01	0.66700	0.16900	1.19e-02	-0.168000	9.43e-01	3.12e-01
Cell Cycle	483	7.95e-06	0.00465	0.16800	-1.10e-01	-0.127000	4.27e-05	2.25e-06
Extracellular matrix organization	73	7.83e-02	0.41000	0.16800	1.49e-01	0.079000	2.85e-02	2.44e-01
Aquaporin-mediated transport	19	3.93e-01	0.71200	0.16800	5.24e-02	0.160000	6.92e-01	2.29e-01
IRE1alpha activates chaperones	40	3.74e-01	0.71100	0.16800	-1.20e-01	-0.117000	1.90e-01	2.00e-01
Smooth Muscle Contraction	19	6.27e-01	0.82400	0.16700	-1.20e-01	-0.117000	3.66e-01	3.77e-01
HIV elongation arrest and recovery	23	4.57e-01	0.73600	0.16700	-7.98e-02	-0.147000	5.08e-01	2.23e-01
Pausing and recovery of HIV elongation	23	4.57e-01	0.73600	0.16700	-7.98e-02	-0.147000	5.08e-01	2.23e-01
Apoptotic cleavage of cellular proteins	22	1.28e-01	0.48900	0.16700	1.67e-01	-0.013800	1.77e-01	9.11e-01
rRNA modification in the nucleus and cytosol	44	2.32e-02	0.22800	0.16700	3.07e-03	-0.167000	9.72e-01	5.56e-02
GAB1 signalosome	10	4.61e-01	0.73800	0.16700	1.67e-01	0.008720	3.62e-01	9.62e-01
Mitochondrial translation	84	7.45e-03	0.13600	0.16700	-1.63e-01	-0.035700	1.00e-02	5.72e-01
Peptide hormone metabolism	27	5.14e-01	0.77200	0.16600	1.25e-01	0.110000	2.63e-01	3.23e-01
Degradation of the extracellular matrix	28	4.70e-01	0.73800	0.16600	1.34e-01	0.098000	2.19e-01	3.70e-01
RUNX3 regulates NOTCH signaling	11	3.74e-01	0.71100	0.16600	1.66e-01	-0.009500	3.41e-01	9.57e-01
RHOG GTPase cycle	44	5.14e-02	0.35400	0.16600	2.15e-02	0.165000	8.05e-01	5.92e-02
RHOJ GTPase cycle	34	4.31e-01	0.72100	0.16600	1.26e-01	0.108000	2.04e-01	2.76e-01
Orc1 removal from chromatin	53	2.81e-01	0.62300	0.16500	-1.15e-01	-0.119000	1.49e-01	1.34e-01
Regulation of TP53 Activity	128	2.56e-02	0.23500	0.16500	-9.03e-02	-0.139000	7.87e-02	6.96e-03
Suppression of phagosomal maturation	11	7.27e-01	0.89000	0.16500	-1.39e-01	-0.089900	4.26e-01	6.06e-01
G2/M Transition	145	3.10e-02	0.26300	0.16500	-1.23e-01	-0.110000	1.07e-02	2.30e-02
Formation of tubulin folding intermediates by CCT/TriC	13	5.07e-01	0.76700	0.16500	-1.59e-01	-0.043200	3.21e-01	7.87e-01
tRNA modification in the nucleus and cytosol	30	2.88e-01	0.62700	0.16400	-6.11e-02	-0.153000	5.63e-01	1.48e-01
Cell-Cell communication	41	2.22e-01	0.58000	0.16400	6.95e-02	0.148000	4.42e-01	1.00e-01
Regulation of PTEN stability and activity	52	2.10e-01	0.56600	0.16300	-8.39e-02	-0.140000	2.96e-01	8.06e-02
Unwinding of DNA	10	4.75e-01	0.73800	0.16300	1.63e-01	0.007950	3.72e-01	9.65e-01
RND3 GTPase cycle	29	3.18e-01	0.66200	0.16300	6.26e-02	0.150000	5.60e-01	1.61e-01
The citric acid (TCA) cycle and respiratory electron transport	109	5.88e-02	0.37200	0.16300	-1.32e-01	-0.094600	1.73e-02	8.90e-02
HCMV Infection	67	2.12e-01	0.56800	0.16200	-1.19e-01	-0.111000	9.32e-02	1.18e-01
Regulation of RUNX2 expression and activity	54	2.88e-01	0.62700	0.16200	-1.12e-01	-0.118000	1.57e-01	1.35e-01
Regulation of BACH1 activity	11	2.56e-01	0.60300	0.16200	-1.45e-01	0.073300	4.07e-01	6.74e-01
Deactivation of the beta-catenin transactivating complex	26	4.06e-01	0.71500	0.16200	-1.45e-01	-0.070900	2.00e-01	5.32e-01
Downstream TCR signaling	64	1.69e-01	0.51200	0.16200	-1.36e-01	-0.087200	6.03e-02	2.28e-01
Glucagon signaling in metabolic regulation	14	7.12e-01	0.88000	0.16100	9.94e-02	0.126000	5.20e-01	4.13e-01
SUMOylation of DNA methylation proteins	14	7.29e-01	0.89100	0.16100	1.14e-01	0.113000	4.61e-01	4.63e-01
Cellular response to hypoxia	56	2.36e-01	0.59500	0.16000	-1.31e-01	-0.090500	8.95e-02	2.42e-01
Protein-protein interactions at synapses	31	4.99e-01	0.76000	0.15900	1.07e-01	0.118000	3.04e-01	2.56e-01
Hedgehog ‘off’ state	70	1.74e-01	0.51400	0.15900	-1.29e-01	-0.091900	6.16e-02	1.84e-01
Membrane binding and targetting of GAG proteins	11	3.42e-01	0.68300	0.15800	1.55e-01	-0.034000	3.75e-01	8.45e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	11	3.42e-01	0.68300	0.15800	1.55e-01	-0.034000	3.75e-01	8.45e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	57	2.85e-01	0.62600	0.15800	-1.08e-01	-0.116000	1.61e-01	1.30e-01
p75 NTR receptor-mediated signalling	53	1.40e-01	0.49100	0.15800	-1.46e-01	-0.060800	6.65e-02	4.45e-01
Mitochondrial translation termination	78	8.59e-03	0.14500	0.15800	-1.57e-01	-0.020400	1.69e-02	7.56e-01
Metabolism of cofactors	16	6.73e-01	0.85100	0.15800	1.29e-01	0.091900	3.74e-01	5.25e-01
Regulation of PTEN gene transcription	44	2.46e-01	0.59600	0.15800	-1.41e-01	-0.071600	1.07e-01	4.11e-01
HDACs deacetylate histones	28	2.38e-01	0.59500	0.15800	-1.54e-01	-0.035800	1.60e-01	7.43e-01
TP53 Regulates Transcription of Cell Death Genes	29	4.00e-01	0.71200	0.15800	7.21e-02	0.140000	5.02e-01	1.91e-01
SLC-mediated transmembrane transport	91	1.13e-01	0.46300	0.15800	1.27e-01	0.093600	3.70e-02	1.24e-01
Mitotic Metaphase and Anaphase	181	2.09e-02	0.22800	0.15700	-1.13e-01	-0.110000	9.30e-03	1.11e-02
Regulation of insulin secretion	33	1.12e-01	0.46300	0.15700	1.57e-01	0.011500	1.19e-01	9.09e-01
Collagen biosynthesis and modifying enzymes	13	7.39e-01	0.89100	0.15700	1.24e-01	0.096800	4.40e-01	5.46e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	18	6.59e-01	0.84700	0.15700	-1.24e-01	-0.097200	3.64e-01	4.75e-01
Interleukin-7 signaling	14	2.12e-01	0.56800	0.15700	-5.91e-02	0.146000	7.02e-01	3.46e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	82	8.20e-02	0.41800	0.15700	-1.39e-01	-0.073600	3.01e-02	2.50e-01
Transport to the Golgi and subsequent modification	122	6.40e-02	0.37900	0.15700	-9.84e-02	-0.122000	6.14e-02	2.02e-02
Cleavage of the damaged purine	10	3.79e-01	0.71100	0.15700	-1.52e-01	0.036300	4.04e-01	8.42e-01
Depurination	10	3.79e-01	0.71100	0.15700	-1.52e-01	0.036300	4.04e-01	8.42e-01
Recognition and association of DNA glycosylase with site containing an affected purine	10	3.79e-01	0.71100	0.15700	-1.52e-01	0.036300	4.04e-01	8.42e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	7.50e-01	0.89700	0.15600	-1.27e-01	-0.092100	4.48e-01	5.81e-01
Signaling by NOTCH4	65	2.46e-01	0.59600	0.15600	-1.16e-01	-0.105000	1.06e-01	1.45e-01
Response of Mtb to phagocytosis	19	6.64e-01	0.84800	0.15500	-1.16e-01	-0.103000	3.80e-01	4.37e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	150	2.34e-02	0.22800	0.15500	-8.53e-02	-0.130000	7.26e-02	6.26e-03
Glucose metabolism	68	1.45e-01	0.49400	0.15500	-1.35e-01	-0.076400	5.42e-02	2.77e-01
Mitotic G2-G2/M phases	147	4.68e-02	0.33800	0.15500	-1.11e-01	-0.108000	2.04e-02	2.44e-02
FCERI mediated MAPK activation	21	7.64e-02	0.40600	0.15500	-1.12e-01	0.107000	3.76e-01	3.96e-01
Energy dependent regulation of mTOR by LKB1-AMPK	21	4.05e-01	0.71500	0.15400	1.47e-01	0.045000	2.42e-01	7.21e-01
Activation of BH3-only proteins	25	5.94e-01	0.80300	0.15400	1.12e-01	0.106000	3.33e-01	3.61e-01
Mitochondrial translation initiation	79	7.38e-03	0.13600	0.15400	-1.53e-01	-0.012700	1.89e-02	8.46e-01
Interleukin-1 family signaling	89	1.06e-01	0.45700	0.15300	-8.20e-02	-0.130000	1.82e-01	3.51e-02
Mitotic Anaphase	180	2.60e-02	0.23500	0.15300	-1.09e-01	-0.107000	1.18e-02	1.34e-02
Toll Like Receptor 9 (TLR9) Cascade	64	1.64e-01	0.51200	0.15300	-1.34e-01	-0.073500	6.35e-02	3.10e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	61	2.29e-01	0.58800	0.15300	-1.27e-01	-0.085200	8.63e-02	2.51e-01
Biological oxidations	73	1.39e-01	0.49100	0.15300	7.66e-02	0.132000	2.59e-01	5.07e-02
Transport of bile salts and organic acids, metal ions and amine compounds	31	5.11e-01	0.76900	0.15300	9.54e-02	0.119000	3.58e-01	2.50e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	37	1.31e-01	0.49100	0.15300	-2.33e-02	-0.151000	8.06e-01	1.13e-01
mRNA Splicing - Minor Pathway	43	4.04e-01	0.71500	0.15200	-9.75e-02	-0.117000	2.69e-01	1.85e-01
FCERI mediated NF-kB activation	59	2.84e-01	0.62600	0.15200	-1.19e-01	-0.094900	1.16e-01	2.08e-01
Basigin interactions	13	5.64e-01	0.78800	0.15100	3.99e-02	0.146000	8.04e-01	3.62e-01
Signaling by NTRK3 (TRKC)	10	6.65e-01	0.84800	0.15100	4.56e-02	0.144000	8.03e-01	4.29e-01
Intraflagellar transport	30	3.21e-01	0.66500	0.15100	-5.09e-02	-0.143000	6.30e-01	1.77e-01
Circadian Clock	51	2.48e-01	0.59600	0.15100	1.32e-01	0.073500	1.03e-01	3.64e-01
MyD88 dependent cascade initiated on endosome	62	1.81e-01	0.52300	0.15100	-1.33e-01	-0.071900	7.16e-02	3.28e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	62	1.81e-01	0.52300	0.15100	-1.33e-01	-0.071900	7.16e-02	3.28e-01
Metabolism of steroid hormones	13	7.32e-01	0.89100	0.15100	-1.26e-01	-0.082400	4.31e-01	6.07e-01
Ion channel transport	76	1.36e-01	0.49100	0.15000	1.30e-01	0.074500	4.97e-02	2.62e-01
SUMOylation of transcription cofactors	35	2.73e-01	0.61700	0.15000	5.04e-02	0.141000	6.06e-01	1.49e-01
TRAF6 mediated NF-kB activation	19	4.51e-01	0.73200	0.15000	-1.44e-01	-0.041400	2.78e-01	7.55e-01
APC/C-mediated degradation of cell cycle proteins	70	2.50e-01	0.59600	0.14900	-9.93e-02	-0.112000	1.52e-01	1.07e-01
Regulation of mitotic cell cycle	70	2.50e-01	0.59600	0.14900	-9.93e-02	-0.112000	1.52e-01	1.07e-01
SRP-dependent cotranslational protein targeting to membrane	86	1.84e-01	0.52800	0.14800	-1.13e-01	-0.095600	7.09e-02	1.26e-01
Cell Cycle, Mitotic	390	7.52e-04	0.05860	0.14800	-1.02e-01	-0.107000	6.06e-04	3.55e-04
COPI-independent Golgi-to-ER retrograde traffic	28	5.58e-01	0.78700	0.14700	-8.86e-02	-0.118000	4.17e-01	2.81e-01
Josephin domain DUBs	11	7.52e-01	0.89700	0.14700	-1.29e-01	-0.071100	4.60e-01	6.83e-01
Death Receptor Signalling	86	1.60e-01	0.51200	0.14700	-1.20e-01	-0.085000	5.55e-02	1.74e-01
Signaling by RAF1 mutants	25	5.86e-01	0.79900	0.14600	1.20e-01	0.084000	3.01e-01	4.68e-01
CDK-mediated phosphorylation and removal of Cdc6	56	3.51e-01	0.69300	0.14600	-1.07e-01	-0.099300	1.68e-01	1.99e-01
Interconversion of nucleotide di- and triphosphates	18	2.83e-01	0.62500	0.14600	-1.06e-02	0.145000	9.38e-01	2.86e-01
Estrogen-dependent gene expression	67	9.70e-02	0.44100	0.14500	-1.37e-01	-0.048700	5.31e-02	4.91e-01
HCMV Late Events	47	3.97e-01	0.71200	0.14500	-8.98e-02	-0.114000	2.87e-01	1.77e-01
Interleukin-4 and Interleukin-13 signaling	48	7.16e-02	0.39200	0.14500	-1.44e-01	-0.012900	8.39e-02	8.77e-01
Fatty acyl-CoA biosynthesis	19	1.39e-01	0.49100	0.14500	-8.06e-02	0.120000	5.43e-01	3.64e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	18	5.77e-01	0.79500	0.14500	-1.33e-01	-0.057100	3.29e-01	6.75e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	6.17e-01	0.82300	0.14500	-9.71e-02	-0.107000	3.92e-01	3.44e-01
Azathioprine ADME	15	7.51e-01	0.89700	0.14500	9.23e-02	0.111000	5.36e-01	4.55e-01
Transcriptional regulation by RUNX3	70	2.16e-01	0.57300	0.14500	-7.92e-02	-0.121000	2.53e-01	8.06e-02
Loss of Nlp from mitotic centrosomes	52	3.42e-01	0.68300	0.14400	-8.34e-02	-0.118000	2.99e-01	1.43e-01
Loss of proteins required for interphase microtubule organization from the centrosome	52	3.42e-01	0.68300	0.14400	-8.34e-02	-0.118000	2.99e-01	1.43e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23	4.33e-01	0.72200	0.14400	-1.37e-01	-0.043800	2.56e-01	7.16e-01
Intra-Golgi traffic	37	3.44e-01	0.68300	0.14300	-5.90e-02	-0.131000	5.35e-01	1.69e-01
Initiation of Nuclear Envelope (NE) Reformation	17	4.52e-01	0.73200	0.14300	-1.41e-01	-0.024300	3.15e-01	8.62e-01
Signaling by ALK	17	1.97e-01	0.54300	0.14300	-1.28e-01	0.063400	3.61e-01	6.51e-01
RHO GTPase Effectors	182	1.48e-02	0.19900	0.14300	-7.17e-02	-0.123000	9.71e-02	4.27e-03
Asparagine N-linked glycosylation	214	2.16e-02	0.22800	0.14300	-9.33e-02	-0.108000	1.94e-02	6.85e-03
SARS-CoV-2 Infection	203	2.86e-02	0.24600	0.14300	-1.03e-01	-0.098900	1.22e-02	1.57e-02
Centrosome maturation	60	2.85e-01	0.62600	0.14300	-7.95e-02	-0.118000	2.88e-01	1.14e-01
Recruitment of mitotic centrosome proteins and complexes	60	2.85e-01	0.62600	0.14300	-7.95e-02	-0.118000	2.88e-01	1.14e-01
Early Phase of HIV Life Cycle	12	7.97e-01	0.91600	0.14200	-1.12e-01	-0.088300	5.03e-01	5.97e-01
RMTs methylate histone arginines	24	1.28e-01	0.48900	0.14200	-4.37e-02	0.135000	7.11e-01	2.51e-01
Interleukin-15 signaling	11	8.21e-01	0.92100	0.14200	1.05e-01	0.095800	5.46e-01	5.82e-01
PPARA activates gene expression	79	1.59e-01	0.51200	0.14200	1.23e-01	0.070700	5.92e-02	2.78e-01
Recruitment of NuMA to mitotic centrosomes	59	2.60e-01	0.60300	0.14200	-7.17e-02	-0.122000	3.42e-01	1.05e-01
Metabolism of water-soluble vitamins and cofactors	76	2.57e-01	0.60300	0.14100	-9.28e-02	-0.107000	1.63e-01	1.08e-01
Nucleotide salvage	17	6.54e-01	0.84300	0.14100	-1.25e-01	-0.065700	3.72e-01	6.39e-01
Pre-NOTCH Transcription and Translation	27	6.52e-02	0.37900	0.14100	9.18e-02	-0.107000	4.10e-01	3.36e-01
DNA strand elongation	27	3.10e-01	0.65400	0.14100	-2.74e-02	-0.138000	8.06e-01	2.14e-01
Mitochondrial translation elongation	79	1.05e-02	0.16100	0.14000	-1.40e-01	-0.001400	3.17e-02	9.83e-01
Frs2-mediated activation	11	6.55e-01	0.84500	0.13900	-1.35e-01	-0.034700	4.38e-01	8.42e-01
Nuclear Envelope Breakdown	45	4.53e-01	0.73200	0.13900	-1.07e-01	-0.089600	2.16e-01	2.99e-01
Signaling by FGFR1 in disease	23	1.14e-01	0.46300	0.13900	-7.34e-02	0.118000	5.43e-01	3.28e-01
Degradation of AXIN	44	4.76e-01	0.73800	0.13800	-9.34e-02	-0.102000	2.84e-01	2.42e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	4.17e-01	0.71800	0.13800	-1.38e-01	0.001860	3.55e-01	9.90e-01
DNA Damage/Telomere Stress Induced Senescence	24	6.40e-01	0.83200	0.13800	-8.14e-02	-0.111000	4.90e-01	3.45e-01
L1CAM interactions	34	5.34e-01	0.77400	0.13800	1.11e-01	0.081500	2.63e-01	4.11e-01
Formation of RNA Pol II elongation complex	45	4.42e-01	0.72700	0.13700	-1.10e-01	-0.082300	2.02e-01	3.40e-01
RNA Polymerase II Transcription Elongation	45	4.42e-01	0.72700	0.13700	-1.10e-01	-0.082300	2.02e-01	3.40e-01
PI3K Cascade	17	6.61e-01	0.84800	0.13700	-1.22e-01	-0.061000	3.83e-01	6.63e-01
ADORA2B mediated anti-inflammatory cytokines production	28	6.32e-01	0.82900	0.13700	9.36e-02	0.099400	3.92e-01	3.63e-01
RNA Polymerase I Transcription Termination	24	5.72e-01	0.79300	0.13600	1.21e-01	0.062600	3.07e-01	5.96e-01
Vasopressin regulates renal water homeostasis via Aquaporins	18	6.36e-01	0.83000	0.13600	5.80e-02	0.123000	6.70e-01	3.67e-01
MyD88 cascade initiated on plasma membrane	61	2.61e-01	0.60300	0.13600	-1.19e-01	-0.065900	1.09e-01	3.74e-01
Toll Like Receptor 10 (TLR10) Cascade	61	2.61e-01	0.60300	0.13600	-1.19e-01	-0.065900	1.09e-01	3.74e-01
Toll Like Receptor 5 (TLR5) Cascade	61	2.61e-01	0.60300	0.13600	-1.19e-01	-0.065900	1.09e-01	3.74e-01
Negative regulation of MET activity	14	6.97e-01	0.86700	0.13600	-5.60e-02	-0.123000	7.17e-01	4.24e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	28	6.33e-01	0.82900	0.13600	-9.02e-02	-0.101000	4.09e-01	3.55e-01
Signaling by ROBO receptors	146	9.22e-02	0.43300	0.13500	-8.57e-02	-0.104000	7.49e-02	3.13e-02
Signaling by EGFR	35	1.78e-01	0.51900	0.13400	-8.49e-03	-0.134000	9.31e-01	1.70e-01
Assembly Of The HIV Virion	13	4.77e-01	0.73900	0.13400	1.34e-01	-0.005320	4.03e-01	9.73e-01
Signaling by ERBB4	29	7.49e-02	0.40200	0.13400	-1.10e-01	0.076100	3.04e-01	4.78e-01
SUMOylation of DNA damage response and repair proteins	64	3.59e-01	0.70200	0.13300	-1.02e-01	-0.086600	1.61e-01	2.31e-01
Rab regulation of trafficking	81	1.89e-01	0.53600	0.13300	-6.66e-02	-0.116000	3.01e-01	7.27e-02
Pyroptosis	17	6.65e-01	0.84800	0.13300	5.71e-02	0.120000	6.84e-01	3.91e-01
Cyclin E associated events during G1/S transition	68	2.42e-01	0.59600	0.13300	-1.16e-01	-0.065400	9.90e-02	3.52e-01
Anti-inflammatory response favouring Leishmania parasite infection	47	4.72e-01	0.73800	0.13300	1.02e-01	0.085600	2.28e-01	3.10e-01
Leishmania parasite growth and survival	47	4.72e-01	0.73800	0.13300	1.02e-01	0.085600	2.28e-01	3.10e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	15	4.51e-01	0.73200	0.13300	1.33e-01	-0.000373	3.73e-01	9.98e-01
Assembly of the pre-replicative complex	64	3.67e-01	0.70900	0.13300	-8.83e-02	-0.099300	2.23e-01	1.70e-01
Maturation of nucleoprotein	11	7.92e-01	0.91600	0.13200	6.39e-02	0.116000	7.14e-01	5.05e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	10	4.19e-01	0.71800	0.13200	7.46e-02	-0.109000	6.83e-01	5.50e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	7.00e-01	0.86900	0.13200	-1.03e-01	-0.082400	4.02e-01	5.04e-01
Signaling by FLT3 ITD and TKD mutants	12	5.99e-01	0.80300	0.13200	1.72e-02	0.131000	9.18e-01	4.32e-01
Inositol phosphate metabolism	29	2.16e-01	0.57300	0.13100	1.31e-01	-0.002050	2.21e-01	9.85e-01
SARS-CoV Infections	257	1.77e-02	0.21400	0.13100	-1.03e-01	-0.081100	4.77e-03	2.62e-02
RAB geranylgeranylation	37	5.08e-01	0.76700	0.13100	-7.07e-02	-0.110000	4.57e-01	2.47e-01
Signal amplification	16	4.24e-01	0.71800	0.13100	1.30e-01	-0.004540	3.66e-01	9.75e-01
TP53 Regulates Transcription of DNA Repair Genes	45	4.49e-01	0.73200	0.13100	-7.19e-02	-0.109000	4.05e-01	2.07e-01
Regulation of RAS by GAPs	52	4.60e-01	0.73800	0.13000	-9.49e-02	-0.089400	2.37e-01	2.65e-01
Regulation of lipid metabolism by PPARalpha	81	1.91e-01	0.53900	0.13000	1.14e-01	0.062600	7.60e-02	3.31e-01
Interleukin-2 family signaling	27	3.14e-01	0.65700	0.13000	1.40e-02	0.129000	9.00e-01	2.46e-01
Peroxisomal protein import	44	4.66e-01	0.73800	0.13000	-1.08e-01	-0.072300	2.17e-01	4.07e-01
Sulfur amino acid metabolism	17	5.23e-01	0.77400	0.12900	-1.28e-01	-0.022400	3.63e-01	8.73e-01
Peroxisomal lipid metabolism	18	5.70e-01	0.79100	0.12900	-3.60e-02	-0.124000	7.92e-01	3.61e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	13	8.21e-01	0.92100	0.12900	9.86e-02	0.083900	5.39e-01	6.01e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	5.36e-01	0.77400	0.12900	1.15e-01	0.058400	2.83e-01	5.87e-01
Signaling by RAS mutants	29	5.36e-01	0.77400	0.12900	1.15e-01	0.058400	2.83e-01	5.87e-01
Signaling by moderate kinase activity BRAF mutants	29	5.36e-01	0.77400	0.12900	1.15e-01	0.058400	2.83e-01	5.87e-01
Signaling downstream of RAS mutants	29	5.36e-01	0.77400	0.12900	1.15e-01	0.058400	2.83e-01	5.87e-01
Interleukin receptor SHC signaling	15	3.36e-01	0.67800	0.12900	-4.39e-02	0.122000	7.68e-01	4.15e-01
Cyclin A:Cdk2-associated events at S phase entry	70	2.73e-01	0.61700	0.12900	-1.10e-01	-0.066200	1.11e-01	3.39e-01
IGF1R signaling cascade	21	5.61e-01	0.78700	0.12900	-1.21e-01	-0.042900	3.36e-01	7.34e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	21	5.61e-01	0.78700	0.12900	-1.21e-01	-0.042900	3.36e-01	7.34e-01
Activation of HOX genes during differentiation	37	5.57e-01	0.78700	0.12800	-1.03e-01	-0.077300	2.80e-01	4.17e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	37	5.57e-01	0.78700	0.12800	-1.03e-01	-0.077300	2.80e-01	4.17e-01
Growth hormone receptor signaling	16	2.69e-01	0.61600	0.12800	-1.05e-01	0.073500	4.67e-01	6.11e-01
Notch-HLH transcription pathway	21	4.72e-01	0.73800	0.12800	1.26e-01	0.025300	3.19e-01	8.41e-01
RNA Polymerase III Transcription Initiation	35	5.97e-01	0.80300	0.12800	-8.34e-02	-0.097000	3.93e-01	3.21e-01
TGF-beta receptor signaling activates SMADs	36	5.60e-01	0.78700	0.12800	7.47e-02	0.104000	4.39e-01	2.81e-01
Influenza Infection	126	1.68e-01	0.51200	0.12800	-9.09e-02	-0.089800	7.91e-02	8.28e-02
Gluconeogenesis	23	6.96e-01	0.86700	0.12700	-1.03e-01	-0.075700	3.95e-01	5.30e-01
SUMOylation of DNA replication proteins	41	5.52e-01	0.78700	0.12700	-9.58e-02	-0.083900	2.89e-01	3.53e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	15	7.95e-01	0.91600	0.12700	1.01e-01	0.077800	5.00e-01	6.02e-01
Effects of PIP2 hydrolysis	18	3.86e-01	0.71200	0.12700	1.27e-01	-0.008410	3.52e-01	9.51e-01
FGFR1 mutant receptor activation	19	2.16e-01	0.57300	0.12700	-7.42e-02	0.103000	5.76e-01	4.38e-01
G alpha (s) signalling events	38	4.68e-01	0.73800	0.12600	5.84e-02	0.112000	5.34e-01	2.33e-01
CLEC7A (Dectin-1) signaling	77	3.37e-01	0.67800	0.12600	-8.31e-02	-0.094700	2.08e-01	1.52e-01
Insulin receptor recycling	17	5.94e-01	0.80300	0.12600	1.22e-01	0.032700	3.85e-01	8.16e-01
Influenza Viral RNA Transcription and Replication	109	2.24e-01	0.58100	0.12600	-9.00e-02	-0.087800	1.06e-01	1.14e-01
DNA Repair	234	8.11e-03	0.14400	0.12600	-5.48e-02	-0.113000	1.51e-01	3.08e-03
Nuclear events stimulated by ALK signaling in cancer	13	4.28e-01	0.71900	0.12500	-1.20e-01	0.035400	4.53e-01	8.25e-01
MyD88-independent TLR4 cascade	71	3.76e-01	0.71100	0.12500	-9.15e-02	-0.085700	1.84e-01	2.13e-01
TRIF(TICAM1)-mediated TLR4 signaling	71	3.76e-01	0.71100	0.12500	-9.15e-02	-0.085700	1.84e-01	2.13e-01
Amino acids regulate mTORC1	35	5.73e-01	0.79400	0.12500	-1.03e-01	-0.070900	2.92e-01	4.68e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	11	4.70e-01	0.73800	0.12500	-1.17e-01	0.043600	5.01e-01	8.03e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	5.11e-01	0.76900	0.12500	9.54e-03	-0.124000	9.53e-01	4.38e-01
Retrograde transport at the Trans-Golgi-Network	42	9.73e-02	0.44100	0.12400	1.76e-02	-0.123000	8.43e-01	1.68e-01
Mismatch Repair	13	7.99e-01	0.91600	0.12400	-6.46e-02	-0.106000	6.87e-01	5.07e-01
Unfolded Protein Response (UPR)	72	2.90e-01	0.62700	0.12300	-6.29e-02	-0.106000	3.57e-01	1.20e-01
Insulin receptor signalling cascade	23	6.71e-01	0.85100	0.12300	-1.06e-01	-0.062800	3.78e-01	6.03e-01
Transcription of the HIV genome	50	4.60e-01	0.73800	0.12300	-6.82e-02	-0.102000	4.05e-01	2.13e-01
Cap-dependent Translation Initiation	91	2.39e-01	0.59500	0.12200	-6.68e-02	-0.103000	2.72e-01	9.16e-02
Eukaryotic Translation Initiation	91	2.39e-01	0.59500	0.12200	-6.68e-02	-0.103000	2.72e-01	9.16e-02
FOXO-mediated transcription	45	2.33e-01	0.59000	0.12200	2.44e-02	0.120000	7.78e-01	1.65e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	16	8.05e-01	0.91600	0.12200	7.82e-02	0.093800	5.88e-01	5.16e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	16	8.05e-01	0.91600	0.12200	7.82e-02	0.093800	5.88e-01	5.16e-01
Regulation of beta-cell development	15	6.96e-01	0.86700	0.12200	1.14e-01	0.042200	4.43e-01	7.77e-01
rRNA processing	155	2.63e-02	0.23500	0.12200	-4.27e-02	-0.114000	3.61e-01	1.47e-02
Regulation of MECP2 expression and activity	20	5.62e-01	0.78700	0.12100	3.10e-02	0.117000	8.11e-01	3.64e-01
Diseases associated with the TLR signaling cascade	15	7.96e-01	0.91600	0.12100	-6.71e-02	-0.101000	6.53e-01	5.00e-01
Diseases of Immune System	15	7.96e-01	0.91600	0.12100	-6.71e-02	-0.101000	6.53e-01	5.00e-01
PIP3 activates AKT signaling	172	9.30e-02	0.43300	0.12100	-7.30e-02	-0.096600	1.00e-01	2.97e-02
Toll Like Receptor 4 (TLR4) Cascade	86	3.34e-01	0.67800	0.12100	-8.48e-02	-0.086200	1.75e-01	1.68e-01
RHOBTB2 GTPase cycle	19	2.42e-01	0.59600	0.12100	9.03e-02	-0.080400	4.96e-01	5.44e-01
NOTCH3 Intracellular Domain Regulates Transcription	15	7.47e-01	0.89700	0.12100	1.09e-01	0.052800	4.66e-01	7.23e-01
B-WICH complex positively regulates rRNA expression	27	6.41e-01	0.83200	0.12100	1.04e-01	0.061700	3.52e-01	5.79e-01
Cilium Assembly	135	2.60e-02	0.23500	0.12000	-3.27e-02	-0.116000	5.13e-01	2.06e-02
Transport of vitamins, nucleosides, and related molecules	19	7.30e-01	0.89100	0.12000	6.09e-02	0.104000	6.46e-01	4.34e-01
Signaling by Non-Receptor Tyrosine Kinases	33	3.36e-01	0.67800	0.12000	-1.18e-01	-0.019900	2.40e-01	8.43e-01
Signaling by PTK6	33	3.36e-01	0.67800	0.12000	-1.18e-01	-0.019900	2.40e-01	8.43e-01
Major pathway of rRNA processing in the nucleolus and cytosol	145	3.92e-02	0.30200	0.12000	-4.31e-02	-0.112000	3.72e-01	2.06e-02
ERKs are inactivated	11	5.02e-01	0.76200	0.12000	-1.12e-01	0.041000	5.19e-01	8.14e-01
Late endosomal microautophagy	21	4.03e-01	0.71500	0.12000	1.20e-01	-0.000834	3.43e-01	9.95e-01
Regulation of APC/C activators between G1/S and early anaphase	64	4.50e-01	0.73200	0.11900	-8.35e-02	-0.085400	2.49e-01	2.38e-01
ERK/MAPK targets	16	7.93e-01	0.91600	0.11900	-6.78e-02	-0.098300	6.39e-01	4.96e-01
Clathrin-mediated endocytosis	82	1.85e-02	0.21600	0.11900	1.29e-02	-0.118000	8.41e-01	6.44e-02
Association of TriC/CCT with target proteins during biosynthesis	29	4.93e-01	0.75600	0.11900	-1.13e-01	-0.037300	2.94e-01	7.28e-01
PTEN Regulation	104	2.72e-01	0.61700	0.11800	-7.56e-02	-0.090400	1.84e-01	1.12e-01
Signaling by NOTCH1	51	5.00e-01	0.76000	0.11800	6.90e-02	0.095400	3.95e-01	2.39e-01
Protein ubiquitination	56	3.71e-01	0.71100	0.11800	-1.05e-01	-0.053300	1.75e-01	4.91e-01
rRNA processing in the nucleus and cytosol	151	4.86e-02	0.34400	0.11800	-4.60e-02	-0.108000	3.31e-01	2.24e-02
RET signaling	22	7.66e-01	0.90400	0.11700	8.00e-02	0.085600	5.16e-01	4.87e-01
Metal ion SLC transporters	15	5.90e-01	0.80200	0.11700	-1.16e-01	-0.012100	4.35e-01	9.35e-01
PINK1-PRKN Mediated Mitophagy	19	3.18e-01	0.66200	0.11700	-4.14e-02	0.109000	7.55e-01	4.09e-01
DNA Replication	100	3.03e-01	0.64600	0.11700	-8.50e-02	-0.080400	1.43e-01	1.66e-01
Synthesis of PIPs at the early endosome membrane	12	6.83e-01	0.85700	0.11700	-1.86e-02	-0.115000	9.11e-01	4.89e-01
Downstream signaling events of B Cell Receptor (BCR)	66	2.61e-01	0.60300	0.11600	-1.08e-01	-0.044000	1.31e-01	5.37e-01
MAP kinase activation	46	5.81e-01	0.79800	0.11600	-8.31e-02	-0.081100	3.30e-01	3.42e-01
Cargo recognition for clathrin-mediated endocytosis	57	9.10e-02	0.43300	0.11600	4.01e-03	-0.116000	9.58e-01	1.31e-01
Cell surface interactions at the vascular wall	54	4.06e-01	0.71500	0.11600	5.40e-02	0.102000	4.93e-01	1.93e-01
SUMOylation of intracellular receptors	19	7.01e-01	0.86900	0.11500	4.72e-02	0.105000	7.22e-01	4.29e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	64	4.24e-01	0.71800	0.11500	-9.48e-02	-0.065000	1.91e-01	3.69e-01
Toll Like Receptor 2 (TLR2) Cascade	64	4.24e-01	0.71800	0.11500	-9.48e-02	-0.065000	1.91e-01	3.69e-01
Toll Like Receptor TLR1:TLR2 Cascade	64	4.24e-01	0.71800	0.11500	-9.48e-02	-0.065000	1.91e-01	3.69e-01
Toll Like Receptor TLR6:TLR2 Cascade	64	4.24e-01	0.71800	0.11500	-9.48e-02	-0.065000	1.91e-01	3.69e-01
Regulation of KIT signaling	10	8.67e-01	0.94300	0.11500	9.71e-02	0.061500	5.95e-01	7.36e-01
RNA Polymerase III Abortive And Retractive Initiation	38	6.47e-01	0.83700	0.11400	-7.98e-02	-0.081900	3.95e-01	3.83e-01
RNA Polymerase III Transcription	38	6.47e-01	0.83700	0.11400	-7.98e-02	-0.081900	3.95e-01	3.83e-01
Transcription of E2F targets under negative control by DREAM complex	17	3.75e-01	0.71100	0.11400	-1.07e-01	0.040800	4.46e-01	7.71e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	53	5.46e-01	0.78400	0.11400	-8.20e-02	-0.079700	3.03e-01	3.16e-01
Signaling by FGFR2 in disease	23	5.49e-01	0.78600	0.11400	-1.11e-01	-0.027800	3.58e-01	8.17e-01
RHOD GTPase cycle	32	4.75e-01	0.73800	0.11300	3.32e-02	0.108000	7.46e-01	2.89e-01
APC/C:Cdc20 mediated degradation of Cyclin B	19	8.07e-01	0.91600	0.11300	-7.90e-02	-0.081300	5.51e-01	5.40e-01
Synthesis of DNA	93	3.34e-01	0.67800	0.11300	-7.12e-02	-0.088100	2.36e-01	1.43e-01
HIV Infection	175	1.20e-01	0.47100	0.11300	-9.05e-02	-0.068200	3.99e-02	1.22e-01
Metabolic disorders of biological oxidation enzymes	13	8.60e-01	0.94100	0.11300	7.29e-02	0.086600	6.49e-01	5.89e-01
DNA Replication Pre-Initiation	77	4.07e-01	0.71500	0.11300	-7.18e-02	-0.087400	2.77e-01	1.86e-01
Diseases of glycosylation	65	1.52e-01	0.50900	0.11200	1.11e-01	0.018300	1.23e-01	7.99e-01
Signaling by Hedgehog	93	3.08e-01	0.65200	0.11200	-9.23e-02	-0.063700	1.25e-01	2.90e-01
G1/S Transition	103	2.70e-01	0.61600	0.11200	-9.24e-02	-0.063300	1.06e-01	2.68e-01
Ovarian tumor domain proteases	29	7.22e-01	0.88700	0.11200	-7.37e-02	-0.084300	4.92e-01	4.32e-01
Cell recruitment (pro-inflammatory response)	15	6.26e-01	0.82400	0.11200	1.29e-02	0.111000	9.31e-01	4.57e-01
Purinergic signaling in leishmaniasis infection	15	6.26e-01	0.82400	0.11200	1.29e-02	0.111000	9.31e-01	4.57e-01
Glycosaminoglycan metabolism	60	3.99e-01	0.71200	0.11200	9.84e-02	0.052500	1.88e-01	4.82e-01
RHOBTB1 GTPase cycle	18	7.95e-01	0.91600	0.11100	6.20e-02	0.092200	6.49e-01	4.99e-01
Toll-like Receptor Cascades	96	3.11e-01	0.65400	0.11100	-9.05e-02	-0.064400	1.27e-01	2.77e-01
Heme biosynthesis	10	8.38e-01	0.93000	0.11100	-4.45e-02	-0.102000	8.07e-01	5.78e-01
IRS-mediated signalling	19	5.34e-01	0.77400	0.11000	-1.10e-01	-0.006800	4.08e-01	9.59e-01
HIV Transcription Initiation	36	5.31e-01	0.77400	0.11000	-4.33e-02	-0.101000	6.53e-01	2.95e-01
RNA Polymerase II HIV Promoter Escape	36	5.31e-01	0.77400	0.11000	-4.33e-02	-0.101000	6.53e-01	2.95e-01
RNA Polymerase II Promoter Escape	36	5.31e-01	0.77400	0.11000	-4.33e-02	-0.101000	6.53e-01	2.95e-01
RNA Polymerase II Transcription Initiation	36	5.31e-01	0.77400	0.11000	-4.33e-02	-0.101000	6.53e-01	2.95e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	36	5.31e-01	0.77400	0.11000	-4.33e-02	-0.101000	6.53e-01	2.95e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	36	5.31e-01	0.77400	0.11000	-4.33e-02	-0.101000	6.53e-01	2.95e-01
NR1H2 and NR1H3-mediated signaling	24	7.75e-01	0.90900	0.10900	8.11e-02	0.073300	4.92e-01	5.35e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	84	4.00e-01	0.71200	0.10900	-8.49e-02	-0.067900	1.79e-01	2.83e-01
Nonsense-Mediated Decay (NMD)	84	4.00e-01	0.71200	0.10900	-8.49e-02	-0.067900	1.79e-01	2.83e-01
Response of EIF2AK1 (HRI) to heme deficiency	13	8.64e-01	0.94200	0.10900	8.64e-02	0.065800	5.90e-01	6.81e-01
CTLA4 inhibitory signaling	15	8.47e-01	0.93600	0.10900	6.68e-02	0.085600	6.54e-01	5.66e-01
DAP12 interactions	19	7.26e-01	0.89000	0.10800	-9.93e-02	-0.043700	4.54e-01	7.42e-01
Constitutive Signaling by Aberrant PI3K in Cancer	27	6.97e-01	0.86700	0.10800	-5.50e-02	-0.093300	6.21e-01	4.02e-01
RHOC GTPase cycle	45	1.06e-01	0.45800	0.10800	-1.03e-01	0.033800	2.33e-01	6.95e-01
Fanconi Anemia Pathway	28	2.89e-01	0.62700	0.10800	2.13e-02	-0.106000	8.45e-01	3.34e-01
RNA Polymerase I Transcription Initiation	39	5.29e-01	0.77400	0.10800	9.82e-02	0.044100	2.89e-01	6.34e-01
Nuclear events mediated by NFE2L2	63	1.75e-01	0.51400	0.10700	-1.06e-01	-0.014500	1.46e-01	8.42e-01
Dual Incision in GG-NER	34	4.74e-01	0.73800	0.10700	-2.82e-02	-0.103000	7.76e-01	2.98e-01
Signaling by ERBB2	33	5.84e-01	0.79900	0.10700	-4.33e-02	-0.097800	6.67e-01	3.31e-01
Role of phospholipids in phagocytosis	14	4.66e-01	0.73800	0.10600	9.30e-02	-0.051900	5.47e-01	7.37e-01
Signaling by FLT3 fusion proteins	15	5.86e-01	0.79900	0.10600	-4.55e-03	0.106000	9.76e-01	4.78e-01
Fatty acid metabolism	90	4.14e-01	0.71800	0.10600	7.68e-02	0.072900	2.09e-01	2.33e-01
G1/S-Specific Transcription	23	4.68e-01	0.73800	0.10600	1.20e-03	0.106000	9.92e-01	3.80e-01
Amino acid transport across the plasma membrane	15	8.21e-01	0.92100	0.10600	9.19e-02	0.052300	5.38e-01	7.26e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	6.20e-01	0.82400	0.10600	-3.60e-03	-0.106000	9.81e-01	4.79e-01
Nicotinate metabolism	16	8.04e-01	0.91600	0.10600	5.03e-02	0.092900	7.27e-01	5.20e-01
TP53 Regulates Metabolic Genes	61	5.28e-01	0.77400	0.10500	-6.43e-02	-0.083500	3.86e-01	2.60e-01
Signaling by FGFR in disease	38	2.03e-01	0.55100	0.10500	-1.03e-01	0.020500	2.72e-01	8.27e-01
SUMOylation of chromatin organization proteins	45	2.29e-01	0.58800	0.10500	-1.05e-01	-0.000427	2.23e-01	9.96e-01
Transcriptional Regulation by TP53	272	7.57e-02	0.40400	0.10500	-7.14e-02	-0.077000	4.43e-02	3.00e-02
TRAF6 mediated IRF7 activation	16	4.20e-01	0.71800	0.10500	-5.79e-02	0.087100	6.89e-01	5.47e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	15	7.39e-01	0.89100	0.10400	1.00e-01	0.029200	5.03e-01	8.45e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	15	7.39e-01	0.89100	0.10400	1.00e-01	0.029200	5.03e-01	8.45e-01
Plasma lipoprotein assembly, remodeling, and clearance	35	4.87e-01	0.75100	0.10300	-2.63e-02	-0.099300	7.88e-01	3.10e-01
Switching of origins to a post-replicative state	69	5.29e-01	0.77400	0.10200	-7.57e-02	-0.068800	2.78e-01	3.24e-01
Oxidative Stress Induced Senescence	51	4.80e-01	0.74100	0.10200	-4.27e-02	-0.092800	5.98e-01	2.52e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	10	8.82e-01	0.94900	0.10200	8.94e-02	0.049300	6.25e-01	7.87e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	54	1.74e-01	0.51400	0.10200	2.88e-03	-0.102000	9.71e-01	1.95e-01
Golgi Associated Vesicle Biogenesis	37	2.54e-01	0.60000	0.10200	1.01e-01	-0.014600	2.90e-01	8.78e-01
RNA polymerase II transcribes snRNA genes	65	5.59e-01	0.78700	0.10100	-7.31e-02	-0.069900	3.09e-01	3.31e-01
MTOR signalling	32	5.11e-01	0.76900	0.10100	9.84e-02	0.022800	3.36e-01	8.23e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	28	2.69e-01	0.61600	0.10100	-9.16e-02	0.042300	4.02e-01	6.99e-01
L13a-mediated translational silencing of Ceruloplasmin expression	83	2.77e-01	0.62000	0.10100	-3.76e-02	-0.093600	5.55e-01	1.41e-01
Toll Like Receptor 3 (TLR3) Cascade	71	5.37e-01	0.77500	0.10000	-6.95e-02	-0.072100	3.12e-01	2.94e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	13	7.39e-01	0.89100	0.10000	-1.62e-02	-0.098700	9.19e-01	5.38e-01
Listeria monocytogenes entry into host cells	14	7.62e-01	0.90200	0.09980	-2.54e-02	-0.096500	8.69e-01	5.32e-01
Prefoldin mediated transfer of substrate to CCT/TriC	16	8.25e-01	0.92300	0.09950	-8.73e-02	-0.047700	5.45e-01	7.41e-01
NOTCH4 Intracellular Domain Regulates Transcription	14	5.32e-01	0.77400	0.09950	3.96e-02	-0.091300	7.98e-01	5.54e-01
RNA Polymerase I Promoter Escape	26	7.98e-01	0.91600	0.09880	7.39e-02	0.065500	5.15e-01	5.63e-01
Chromatin modifying enzymes	139	9.30e-02	0.43300	0.09870	-9.41e-02	-0.029800	5.65e-02	5.46e-01
Chromatin organization	139	9.30e-02	0.43300	0.09870	-9.41e-02	-0.029800	5.65e-02	5.46e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	38	3.63e-01	0.70500	0.09840	-9.82e-02	-0.005460	2.95e-01	9.54e-01
RHO GTPases activate PKNs	26	6.77e-01	0.85300	0.09820	-3.59e-02	-0.091400	7.51e-01	4.20e-01
Downstream signal transduction	20	5.18e-01	0.77400	0.09790	-9.95e-03	0.097400	9.39e-01	4.51e-01
C-type lectin receptors (CLRs)	92	4.17e-01	0.71800	0.09760	-8.00e-02	-0.055900	1.86e-01	3.55e-01
S Phase	127	3.49e-01	0.69200	0.09710	-7.21e-02	-0.065100	1.62e-01	2.07e-01
trans-Golgi Network Vesicle Budding	50	9.67e-02	0.44100	0.09650	7.70e-02	-0.058100	3.47e-01	4.78e-01
Activation of ATR in response to replication stress	29	5.35e-01	0.77400	0.09640	-1.54e-02	-0.095100	8.86e-01	3.76e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	29	7.33e-01	0.89100	0.09630	8.33e-02	0.048300	4.38e-01	6.52e-01
Formation of a pool of free 40S subunits	75	3.28e-01	0.67400	0.09580	-3.30e-02	-0.089900	6.22e-01	1.79e-01
RAF-independent MAPK1/3 activation	19	7.67e-01	0.90400	0.09580	3.58e-02	0.088800	7.87e-01	5.03e-01
Glycolysis	54	3.05e-01	0.64800	0.09540	-9.45e-02	-0.013100	2.30e-01	8.68e-01
Regulation of actin dynamics for phagocytic cup formation	42	6.10e-01	0.81700	0.09500	-8.51e-02	-0.042300	3.41e-01	6.36e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	84	3.52e-01	0.69300	0.09490	-3.96e-02	-0.086300	5.31e-01	1.73e-01
Peptide chain elongation	67	5.90e-01	0.80200	0.09480	-6.54e-02	-0.068700	3.56e-01	3.32e-01
Eukaryotic Translation Elongation	70	5.64e-01	0.78800	0.09470	-7.31e-02	-0.060300	2.91e-01	3.84e-01
RHOB GTPase cycle	40	4.91e-01	0.75200	0.09460	-9.17e-02	-0.023000	3.16e-01	8.01e-01
MET promotes cell motility	11	9.17e-01	0.96500	0.09400	6.32e-02	0.069600	7.17e-01	6.89e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	21	8.31e-01	0.92400	0.09390	7.68e-02	0.054100	5.43e-01	6.68e-01
Mitophagy	23	4.53e-01	0.73200	0.09310	-2.21e-02	0.090400	8.55e-01	4.53e-01
O-linked glycosylation of mucins	24	6.16e-01	0.82200	0.09190	9.10e-02	0.013300	4.41e-01	9.11e-01
Apoptosis	124	4.08e-01	0.71500	0.09130	-6.44e-02	-0.064700	2.17e-01	2.15e-01
RND2 GTPase cycle	33	7.86e-01	0.91600	0.09110	6.33e-02	0.065500	5.29e-01	5.15e-01
RNA Pol II CTD phosphorylation and interaction with CE	23	4.25e-01	0.71800	0.09070	8.35e-02	-0.035500	4.89e-01	7.68e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	23	4.25e-01	0.71800	0.09070	8.35e-02	-0.035500	4.89e-01	7.68e-01
NOTCH1 Intracellular Domain Regulates Transcription	37	6.93e-01	0.86700	0.09070	4.36e-02	0.079500	6.47e-01	4.03e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	59	5.97e-01	0.80300	0.09060	-4.90e-02	-0.076200	5.16e-01	3.12e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	15	7.55e-01	0.89800	0.09050	-1.55e-02	-0.089200	9.17e-01	5.50e-01
Organelle biogenesis and maintenance	187	4.09e-02	0.31000	0.08960	-1.80e-02	-0.087800	6.73e-01	3.94e-02
E2F mediated regulation of DNA replication	12	7.72e-01	0.90700	0.08930	8.91e-02	0.006300	5.93e-01	9.70e-01
Mitochondrial protein import	40	2.46e-01	0.59600	0.08900	3.23e-02	-0.082900	7.24e-01	3.65e-01
Late Phase of HIV Life Cycle	106	4.76e-01	0.73800	0.08850	-6.72e-02	-0.057500	2.33e-01	3.08e-01
Intracellular signaling by second messengers	194	1.44e-01	0.49200	0.08790	-3.88e-02	-0.078800	3.54e-01	5.97e-02
RND1 GTPase cycle	29	5.42e-01	0.77900	0.08790	5.39e-03	0.087700	9.60e-01	4.14e-01
HIV Life Cycle	117	4.45e-01	0.73100	0.08790	-6.70e-02	-0.056800	2.12e-01	2.90e-01
RHOV GTPase cycle	25	6.36e-01	0.83000	0.08770	1.35e-02	0.086700	9.07e-01	4.53e-01
The NLRP3 inflammasome	12	8.48e-01	0.93600	0.08730	8.35e-02	0.025700	6.17e-01	8.78e-01
Mitotic G1 phase and G1/S transition	118	3.97e-01	0.71200	0.08730	-7.25e-02	-0.048500	1.75e-01	3.64e-01
SUMO E3 ligases SUMOylate target proteins	127	4.35e-01	0.72400	0.08690	-6.26e-02	-0.060300	2.25e-01	2.42e-01
Eukaryotic Translation Termination	70	6.27e-01	0.82400	0.08680	-6.47e-02	-0.057900	3.50e-01	4.03e-01
RHO GTPases Activate WASPs and WAVEs	28	8.30e-01	0.92400	0.08670	-6.44e-02	-0.058100	5.55e-01	5.95e-01
Elastic fibre formation	13	7.56e-01	0.89800	0.08670	8.66e-02	0.002630	5.89e-01	9.87e-01
KEAP1-NFE2L2 pathway	81	2.58e-01	0.60300	0.08650	-8.51e-02	-0.015500	1.86e-01	8.09e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	7.66e-01	0.90400	0.08640	-3.90e-04	-0.086400	9.98e-01	6.04e-01
Signaling by PDGF	24	4.14e-01	0.71700	0.08620	-4.77e-02	0.071800	6.86e-01	5.43e-01
Potential therapeutics for SARS	63	2.70e-01	0.61600	0.08620	-8.61e-02	-0.003800	2.38e-01	9.58e-01
TP53 Regulates Transcription of Cell Cycle Genes	40	7.36e-01	0.89100	0.08590	-4.76e-02	-0.071600	6.03e-01	4.34e-01
Mitochondrial Fatty Acid Beta-Oxidation	25	7.18e-01	0.88400	0.08590	8.20e-02	0.025400	4.78e-01	8.26e-01
Degradation of beta-catenin by the destruction complex	64	6.24e-01	0.82400	0.08590	-7.03e-02	-0.049300	3.31e-01	4.96e-01
Positive epigenetic regulation of rRNA expression	40	6.45e-01	0.83600	0.08580	7.92e-02	0.032900	3.87e-01	7.19e-01
Protein methylation	10	7.01e-01	0.86900	0.08550	4.33e-02	-0.073700	8.13e-01	6.86e-01
GPER1 signaling	20	8.79e-01	0.94900	0.08490	6.41e-02	0.055700	6.20e-01	6.66e-01
Signaling by the B Cell Receptor (BCR)	84	3.70e-01	0.71100	0.08490	-8.00e-02	-0.028500	2.06e-01	6.52e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	20	8.83e-01	0.94900	0.08440	5.90e-02	0.060400	6.48e-01	6.40e-01
Nuclear signaling by ERBB4	14	8.07e-01	0.91600	0.08340	1.61e-02	0.081900	9.17e-01	5.96e-01
FCGR3A-mediated phagocytosis	40	6.79e-01	0.85300	0.08330	-7.58e-02	-0.034500	4.07e-01	7.06e-01
Leishmania phagocytosis	40	6.79e-01	0.85300	0.08330	-7.58e-02	-0.034500	4.07e-01	7.06e-01
Parasite infection	40	6.79e-01	0.85300	0.08330	-7.58e-02	-0.034500	4.07e-01	7.06e-01
Polo-like kinase mediated events	16	6.00e-01	0.80500	0.08320	-3.47e-02	0.075600	8.10e-01	6.01e-01
Signaling by VEGF	72	4.17e-01	0.71800	0.08290	7.90e-02	0.024900	2.47e-01	7.15e-01
Signaling by NTRK1 (TRKA)	79	1.39e-01	0.49100	0.08270	-8.16e-02	0.013400	2.11e-01	8.38e-01
Mitochondrial iron-sulfur cluster biogenesis	12	6.96e-01	0.86700	0.08270	2.96e-02	-0.077200	8.59e-01	6.44e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	19	8.91e-01	0.95200	0.08260	5.55e-02	0.061200	6.76e-01	6.44e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	8.82e-01	0.94900	0.08230	7.78e-02	0.026900	6.55e-01	8.77e-01
Dual incision in TC-NER	55	1.54e-01	0.51200	0.08220	5.06e-02	-0.064900	5.17e-01	4.06e-01
Signaling by NOTCH2	18	7.59e-01	0.90000	0.08210	-1.42e-02	-0.080900	9.17e-01	5.53e-01
GPVI-mediated activation cascade	21	8.60e-01	0.94100	0.08190	-4.41e-02	-0.069000	7.26e-01	5.84e-01
Protein localization	110	3.86e-01	0.71200	0.08180	-3.64e-02	-0.073200	5.11e-01	1.86e-01
mTORC1-mediated signalling	17	9.04e-01	0.95600	0.08170	-6.02e-02	-0.055300	6.68e-01	6.93e-01
Metabolism of nucleotides	64	3.98e-01	0.71200	0.08170	-8.00e-02	-0.016300	2.69e-01	8.22e-01
EPHB-mediated forward signaling	25	8.64e-01	0.94200	0.08160	-5.77e-02	-0.057800	6.18e-01	6.17e-01
IRS-related events triggered by IGF1R	20	7.09e-01	0.87800	0.08110	-8.08e-02	-0.007380	5.32e-01	9.54e-01
VEGFA-VEGFR2 Pathway	70	4.28e-01	0.71900	0.08110	7.78e-02	0.022800	2.61e-01	7.42e-01
Iron uptake and transport	36	6.38e-01	0.83100	0.08100	-7.81e-02	-0.021700	4.18e-01	8.22e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	49	7.52e-01	0.89700	0.08020	-5.16e-02	-0.061400	5.33e-01	4.58e-01
Apoptotic execution phase	30	4.32e-01	0.72100	0.08020	2.75e-02	-0.075300	7.95e-01	4.76e-01
Costimulation by the CD28 family	41	5.81e-01	0.79800	0.07990	1.77e-02	0.077900	8.45e-01	3.88e-01
Fc epsilon receptor (FCERI) signaling	100	3.93e-01	0.71200	0.07990	-7.36e-02	-0.031100	2.05e-01	5.92e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	18	8.60e-01	0.94100	0.07980	3.52e-02	0.071700	7.96e-01	5.99e-01
Formation of TC-NER Pre-Incision Complex	45	3.76e-01	0.71100	0.07970	7.92e-02	-0.008320	3.59e-01	9.23e-01
ECM proteoglycans	10	7.53e-01	0.89700	0.07960	7.38e-02	-0.029900	6.86e-01	8.70e-01
Cellular response to starvation	110	5.49e-01	0.78600	0.07920	-5.70e-02	-0.054900	3.03e-01	3.21e-01
G0 and Early G1	24	4.64e-01	0.73800	0.07920	-5.89e-02	0.052900	6.18e-01	6.54e-01
Programmed Cell Death	144	4.28e-01	0.71900	0.07910	-4.78e-02	-0.063000	3.24e-01	1.94e-01
Intrinsic Pathway for Apoptosis	43	4.89e-01	0.75200	0.07880	5.93e-03	0.078600	9.46e-01	3.73e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	8.45e-01	0.93600	0.07880	-5.52e-03	-0.078600	9.76e-01	6.67e-01
EPH-ephrin mediated repulsion of cells	24	8.02e-01	0.91600	0.07880	7.26e-02	0.030500	5.38e-01	7.96e-01
TNFR1-induced NFkappaB signaling pathway	19	7.39e-01	0.89100	0.07840	-7.59e-03	-0.078000	9.54e-01	5.56e-01
Cytokine Signaling in Immune system	392	6.54e-02	0.37900	0.07830	-6.81e-02	-0.038500	2.20e-02	1.96e-01
Synthesis of substrates in N-glycan biosythesis	46	7.59e-01	0.90000	0.07810	-4.58e-02	-0.063300	5.92e-01	4.58e-01
Infectious disease	591	4.86e-02	0.34400	0.07780	-5.87e-02	-0.051100	1.66e-02	3.70e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	27	8.28e-01	0.92300	0.07720	-3.84e-02	-0.067100	7.30e-01	5.47e-01
Sema3A PAK dependent Axon repulsion	10	9.48e-01	0.97300	0.07680	-5.82e-02	-0.050100	7.50e-01	7.84e-01
Transcriptional Regulation by E2F6	26	6.70e-01	0.85100	0.07630	-7.60e-02	-0.006260	5.02e-01	9.56e-01
Cellular responses to stimuli	513	8.32e-02	0.41900	0.07630	-5.36e-02	-0.054200	4.05e-02	3.83e-02
RHOBTB GTPase Cycle	28	5.84e-01	0.79900	0.07610	5.71e-03	-0.075900	9.58e-01	4.87e-01
Transcriptional regulation by RUNX2	78	6.23e-01	0.82400	0.07580	-6.37e-02	-0.041200	3.32e-01	5.30e-01
CD28 co-stimulation	27	7.99e-01	0.91600	0.07530	6.93e-02	0.029700	5.34e-01	7.90e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	9.42e-01	0.97300	0.07530	5.21e-02	0.054300	7.55e-01	7.45e-01
Trafficking of AMPA receptors	12	9.42e-01	0.97300	0.07530	5.21e-02	0.054300	7.55e-01	7.45e-01
Signaling by TGFB family members	81	9.77e-02	0.44100	0.07520	-5.46e-02	0.051700	3.97e-01	4.22e-01
Synthesis of PIPs at the plasma membrane	34	8.44e-01	0.93600	0.07500	5.07e-02	0.055300	6.10e-01	5.77e-01
Cellular responses to stress	509	9.26e-02	0.43300	0.07490	-5.31e-02	-0.052800	4.31e-02	4.46e-02
Viral mRNA Translation	67	7.21e-01	0.88600	0.07480	-5.26e-02	-0.053100	4.57e-01	4.53e-01
Signaling by ERBB2 KD Mutants	12	7.90e-01	0.91600	0.07450	-9.39e-03	0.073900	9.55e-01	6.58e-01
APC-Cdc20 mediated degradation of Nek2A	21	8.77e-01	0.94900	0.07450	-6.39e-02	-0.038200	6.12e-01	7.62e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	6.70e-01	0.85100	0.07440	-6.11e-02	-0.042500	3.71e-01	5.34e-01
Nuclear Envelope (NE) Reassembly	56	3.25e-01	0.66800	0.07430	-7.34e-02	0.011600	3.43e-01	8.81e-01
NCAM signaling for neurite out-growth	21	7.75e-01	0.90900	0.07420	7.28e-02	0.014000	5.64e-01	9.11e-01
TCR signaling	77	5.69e-01	0.79000	0.07350	-6.66e-02	-0.031300	3.14e-01	6.36e-01
Vesicle-mediated transport	416	9.02e-04	0.05960	0.07350	4.35e-03	-0.073400	8.80e-01	1.12e-02
Neddylation	175	2.27e-01	0.58700	0.07340	-6.87e-02	-0.025900	1.19e-01	5.56e-01
RNA Polymerase I Promoter Clearance	43	7.17e-01	0.88300	0.07320	6.71e-02	0.029100	4.47e-01	7.42e-01
RNA Polymerase I Transcription	43	7.17e-01	0.88300	0.07320	6.71e-02	0.029100	4.47e-01	7.42e-01
Stimuli-sensing channels	35	6.21e-01	0.82400	0.07300	7.26e-02	0.007550	4.58e-01	9.38e-01
FOXO-mediated transcription of cell cycle genes	12	9.14e-01	0.96300	0.07290	2.98e-02	0.066600	8.58e-01	6.90e-01
Metabolism of lipids	401	6.57e-02	0.37900	0.07290	6.56e-02	0.031900	2.59e-02	2.79e-01
Signaling by NTRK2 (TRKB)	15	7.55e-01	0.89800	0.07240	-7.17e-02	0.009960	6.31e-01	9.47e-01
RHOH GTPase cycle	25	5.25e-01	0.77400	0.07140	-4.44e-02	0.055800	7.01e-01	6.29e-01
SARS-CoV-1 Infection	44	5.87e-01	0.80000	0.07130	-1.04e-02	-0.070500	9.05e-01	4.19e-01
Activation of the pre-replicative complex	23	7.70e-01	0.90600	0.07100	6.99e-02	0.012600	5.62e-01	9.17e-01
Transport of small molecules	320	1.02e-01	0.45000	0.07090	6.52e-02	0.027800	4.68e-02	3.96e-01
Senescence-Associated Secretory Phenotype (SASP)	39	5.96e-01	0.80300	0.07090	-7.06e-02	-0.005970	4.46e-01	9.49e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	16	6.63e-01	0.84800	0.07080	-4.93e-02	0.050800	7.33e-01	7.25e-01
Interleukin-37 signaling	15	8.03e-01	0.91600	0.07040	7.04e-02	0.000604	6.37e-01	9.97e-01
SLC transporter disorders	48	8.00e-01	0.91600	0.07030	-4.29e-02	-0.055700	6.08e-01	5.05e-01
Membrane Trafficking	409	1.62e-03	0.07500	0.07000	5.68e-03	-0.069700	8.46e-01	1.68e-02
PERK regulates gene expression	26	6.35e-01	0.83000	0.06980	9.77e-03	-0.069200	9.31e-01	5.42e-01
Hedgehog ‘on’ state	60	6.37e-01	0.83000	0.06980	-6.50e-02	-0.025600	3.85e-01	7.32e-01
Sialic acid metabolism	22	8.75e-01	0.94900	0.06980	6.18e-02	0.032500	6.16e-01	7.92e-01
Negative regulation of the PI3K/AKT network	54	7.86e-01	0.91600	0.06960	-4.37e-02	-0.054200	5.79e-01	4.92e-01
Cell death signalling via NRAGE, NRIF and NADE	39	6.84e-01	0.85700	0.06930	-6.74e-02	-0.016200	4.67e-01	8.61e-01
Signaling by NTRKs	86	1.86e-01	0.53200	0.06910	-6.63e-02	0.019300	2.89e-01	7.58e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	68	2.00e-01	0.55000	0.06830	4.49e-02	-0.051500	5.23e-01	4.64e-01
Signaling by WNT	165	4.47e-01	0.73200	0.06820	5.73e-02	0.037100	2.06e-01	4.13e-01
Cellular Senescence	99	5.61e-01	0.78700	0.06790	-3.09e-02	-0.060400	5.96e-01	3.00e-01
Metabolism of vitamins and cofactors	103	4.90e-01	0.75200	0.06780	-2.55e-02	-0.062800	6.56e-01	2.72e-01
Platelet sensitization by LDL	13	7.48e-01	0.89700	0.06740	-5.69e-02	0.036100	7.22e-01	8.22e-01
The role of Nef in HIV-1 replication and disease pathogenesis	18	7.63e-01	0.90300	0.06740	-5.02e-03	0.067200	9.71e-01	6.22e-01
Diseases of programmed cell death	37	4.51e-01	0.73200	0.06690	5.83e-02	-0.032900	5.40e-01	7.29e-01
Transferrin endocytosis and recycling	19	8.64e-01	0.94200	0.06640	6.31e-02	0.020700	6.34e-01	8.76e-01
Metabolism of steroids	80	4.35e-01	0.72400	0.06630	-9.78e-03	-0.065600	8.80e-01	3.12e-01
Regulation of TP53 Activity through Acetylation	26	6.56e-01	0.84500	0.06610	6.51e-02	-0.011400	5.66e-01	9.20e-01
CD28 dependent PI3K/Akt signaling	18	6.76e-01	0.85300	0.06610	5.42e-02	-0.037700	6.90e-01	7.82e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	31	8.89e-01	0.95200	0.06590	-4.64e-02	-0.046700	6.55e-01	6.53e-01
Selenocysteine synthesis	68	7.68e-01	0.90600	0.06580	-4.31e-02	-0.049800	5.40e-01	4.79e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	21	7.92e-01	0.91600	0.06530	6.19e-03	0.065000	9.61e-01	6.06e-01
Formation of the beta-catenin:TCF transactivating complex	22	7.98e-01	0.91600	0.06460	6.41e-02	0.008180	6.03e-01	9.47e-01
RHOF GTPase cycle	22	6.63e-01	0.84800	0.06440	-2.50e-02	0.059300	8.40e-01	6.30e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	15	9.47e-01	0.97300	0.06390	4.19e-02	0.048200	7.79e-01	7.47e-01
MAP2K and MAPK activation	22	8.97e-01	0.95200	0.06380	5.60e-02	0.030700	6.50e-01	8.03e-01
Signaling by high-kinase activity BRAF mutants	22	8.97e-01	0.95200	0.06380	5.60e-02	0.030700	6.50e-01	8.03e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	23	8.54e-01	0.94100	0.06370	2.07e-02	0.060200	8.63e-01	6.17e-01
Signaling by ERBB2 TMD/JMD mutants	10	8.13e-01	0.91900	0.06360	-4.74e-02	0.042400	7.95e-01	8.16e-01
RHO GTPase cycle	269	3.76e-01	0.71100	0.06360	4.01e-02	0.049400	2.62e-01	1.67e-01
Cargo trafficking to the periciliary membrane	37	4.81e-01	0.74200	0.06350	5.36e-02	-0.034000	5.73e-01	7.20e-01
Global Genome Nucleotide Excision Repair (GG-NER)	75	6.24e-01	0.82400	0.06350	-2.30e-02	-0.059200	7.32e-01	3.76e-01
Interleukin-17 signaling	49	7.81e-01	0.91200	0.06350	-5.62e-02	-0.029500	4.97e-01	7.22e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	14	8.95e-01	0.95200	0.06300	1.53e-02	0.061100	9.21e-01	6.92e-01
Cargo concentration in the ER	18	9.26e-01	0.96900	0.06290	-3.36e-02	-0.053100	8.05e-01	6.97e-01
Diseases associated with glycosylation precursor biosynthesis	15	8.88e-01	0.95200	0.06280	-1.53e-02	-0.061000	9.18e-01	6.83e-01
Nucleotide Excision Repair	98	2.78e-01	0.62100	0.06280	5.05e-03	-0.062600	9.31e-01	2.86e-01
Gene expression (Transcription)	941	5.35e-02	0.36100	0.06230	-4.60e-02	-0.042000	2.01e-02	3.40e-02
Glyoxylate metabolism and glycine degradation	19	9.31e-01	0.97300	0.06200	-5.00e-02	-0.036700	7.06e-01	7.82e-01
Glycerophospholipid biosynthesis	66	6.24e-01	0.82400	0.06190	5.95e-02	0.017100	4.04e-01	8.11e-01
Amyloid fiber formation	25	9.17e-01	0.96500	0.06090	-4.76e-02	-0.038000	6.81e-01	7.42e-01
Fcgamma receptor (FCGR) dependent phagocytosis	59	7.35e-01	0.89100	0.05950	-2.31e-02	-0.054800	7.59e-01	4.67e-01
Activated NOTCH1 Transmits Signal to the Nucleus	19	8.20e-01	0.92100	0.05940	-5.94e-02	-0.000407	6.54e-01	9.98e-01
Diseases of mitotic cell cycle	30	8.05e-01	0.91600	0.05920	5.77e-02	0.013300	5.85e-01	8.99e-01
Hemostasis	279	3.64e-01	0.70600	0.05910	4.97e-02	0.032100	1.57e-01	3.61e-01
Signaling by NOTCH3	30	6.14e-01	0.82100	0.05890	5.26e-02	-0.026400	6.18e-01	8.02e-01
PIWI-interacting RNA (piRNA) biogenesis	15	7.70e-01	0.90600	0.05880	4.68e-02	-0.035600	7.54e-01	8.11e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	75	7.81e-01	0.91200	0.05860	-3.50e-02	-0.047000	6.01e-01	4.83e-01
SUMOylation	132	6.73e-01	0.85100	0.05840	-4.37e-02	-0.038700	3.88e-01	4.44e-01
Postmitotic nuclear pore complex (NPC) reformation	25	7.81e-01	0.91200	0.05780	-5.78e-02	-0.000477	6.17e-01	9.97e-01
RHO GTPases activate PAKs	13	8.75e-01	0.94900	0.05770	1.23e-03	-0.057700	9.94e-01	7.19e-01
Response to elevated platelet cytosolic Ca2+	49	6.52e-01	0.84200	0.05750	5.73e-02	0.004710	4.89e-01	9.55e-01
TNFR1-induced proapoptotic signaling	12	8.29e-01	0.92300	0.05730	2.70e-02	-0.050600	8.71e-01	7.62e-01
Branched-chain amino acid catabolism	20	7.41e-01	0.89100	0.05700	2.39e-02	-0.051800	8.53e-01	6.89e-01
Nephrin family interactions	12	8.99e-01	0.95200	0.05700	3.78e-03	0.056900	9.82e-01	7.33e-01
Signaling by ERBB2 in Cancer	13	8.93e-01	0.95200	0.05640	-5.63e-02	-0.003550	7.25e-01	9.82e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	9.52e-01	0.97300	0.05590	-2.50e-02	-0.050000	8.81e-01	7.64e-01
Chaperonin-mediated protein folding	51	5.18e-01	0.77400	0.05570	-5.33e-02	0.016100	5.11e-01	8.42e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	55	6.22e-01	0.82400	0.05550	-5.54e-02	-0.002380	4.78e-01	9.76e-01
Signaling by Interleukins	248	4.71e-01	0.73800	0.05460	-4.55e-02	-0.030200	2.21e-01	4.16e-01
Budding and maturation of HIV virion	22	9.07e-01	0.95800	0.05460	5.03e-02	0.021100	6.83e-01	8.64e-01
Beta-catenin independent WNT signaling	97	4.51e-01	0.73200	0.05450	5.44e-02	0.002670	3.56e-01	9.64e-01
Platelet activation, signaling and aggregation	120	1.70e-01	0.51200	0.05430	4.28e-02	-0.033400	4.19e-01	5.29e-01
DAP12 signaling	17	9.01e-01	0.95300	0.05430	-5.29e-02	-0.012100	7.06e-01	9.31e-01
Transcriptional regulation of granulopoiesis	23	7.53e-01	0.89700	0.05420	-1.63e-02	0.051700	8.93e-01	6.68e-01
Negative regulators of DDX58/IFIH1 signaling	32	6.93e-01	0.86700	0.05410	-5.27e-02	0.012100	6.06e-01	9.06e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	46	5.75e-01	0.79500	0.05360	1.59e-02	-0.051200	8.53e-01	5.48e-01
Phospholipid metabolism	123	5.51e-01	0.78700	0.05340	5.06e-02	0.017000	3.34e-01	7.45e-01
Epigenetic regulation of gene expression	73	8.28e-01	0.92300	0.05230	4.15e-02	0.031900	5.41e-01	6.38e-01
SUMOylation of transcription factors	13	8.82e-01	0.94900	0.05220	-6.90e-03	0.051800	9.66e-01	7.47e-01
RNA Polymerase II Transcription	835	1.65e-01	0.51200	0.05180	-3.60e-02	-0.037200	8.50e-02	7.47e-02
Cytosolic sensors of pathogen-associated DNA	52	7.33e-01	0.89100	0.05130	-5.05e-02	-0.008830	5.29e-01	9.12e-01
Negative epigenetic regulation of rRNA expression	43	8.97e-01	0.95200	0.05120	4.10e-02	0.030600	6.42e-01	7.29e-01
Post-chaperonin tubulin folding pathway	12	8.78e-01	0.94900	0.05110	-4.89e-02	0.014700	7.69e-01	9.30e-01
Transcriptional Regulation by MECP2	27	7.14e-01	0.88100	0.05100	-4.45e-02	0.024900	6.89e-01	8.23e-01
Phase II - Conjugation of compounds	41	7.96e-01	0.91600	0.05100	1.05e-02	0.049900	9.08e-01	5.81e-01
Metabolism of amino acids and derivatives	214	6.19e-01	0.82400	0.05100	-3.70e-02	-0.035100	3.54e-01	3.79e-01
Asymmetric localization of PCP proteins	49	8.77e-01	0.94900	0.05080	-2.83e-02	-0.042200	7.32e-01	6.10e-01
Transcriptional regulation of white adipocyte differentiation	55	8.58e-01	0.94100	0.05030	4.28e-02	0.026400	5.84e-01	7.35e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	25	7.33e-01	0.89100	0.04930	3.62e-02	-0.033500	7.54e-01	7.72e-01
Transcriptional Regulation by VENTX	24	7.80e-01	0.91200	0.04900	4.63e-02	-0.016000	6.95e-01	8.92e-01
Platelet degranulation	45	8.66e-01	0.94300	0.04830	4.38e-02	0.020400	6.11e-01	8.13e-01
Transcriptional activation of mitochondrial biogenesis	39	8.29e-01	0.92300	0.04820	-4.70e-02	-0.010600	6.12e-01	9.09e-01
Diseases of signal transduction by growth factor receptors and second messengers	284	5.68e-01	0.79000	0.04750	-3.07e-02	-0.036300	3.77e-01	2.97e-01
FCERI mediated Ca+2 mobilization	22	9.54e-01	0.97300	0.04750	2.89e-02	0.037600	8.14e-01	7.60e-01
Disease	1022	1.44e-01	0.49200	0.04740	-2.92e-02	-0.037300	1.26e-01	5.03e-02
RAB GEFs exchange GTP for GDP on RABs	52	7.41e-01	0.89100	0.04730	-4.60e-03	-0.047100	9.54e-01	5.58e-01
Translation of Structural Proteins	27	8.97e-01	0.95200	0.04720	-1.39e-02	-0.045200	9.01e-01	6.85e-01
Interleukin-12 signaling	35	8.03e-01	0.91600	0.04720	-1.92e-03	-0.047100	9.84e-01	6.30e-01
Signal Transduction	1254	1.18e-01	0.46600	0.04710	3.24e-02	0.034100	6.33e-02	5.04e-02
Nuclear Receptor transcription pathway	26	9.49e-01	0.97300	0.04690	-3.01e-02	-0.036000	7.91e-01	7.51e-01
Diseases of metabolism	120	7.50e-01	0.89700	0.04660	3.98e-02	0.024200	4.53e-01	6.48e-01
Antigen processing: Ubiquitination & Proteasome degradation	224	5.49e-01	0.78600	0.04650	2.15e-02	0.041300	5.82e-01	2.90e-01
Signaling by ERBB2 ECD mutants	10	9.76e-01	0.98300	0.04650	2.39e-02	0.039900	8.96e-01	8.27e-01
PCP/CE pathway	68	5.38e-01	0.77600	0.04640	1.44e-02	-0.044200	8.38e-01	5.30e-01
Signaling by NOTCH	127	2.75e-01	0.61800	0.04600	3.97e-02	-0.023300	4.41e-01	6.52e-01
Metabolism of proteins	1162	1.29e-01	0.49100	0.04570	-3.64e-02	-0.027600	4.36e-02	1.27e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	25	9.46e-01	0.97300	0.04560	-2.47e-02	-0.038300	8.31e-01	7.40e-01
TCF dependent signaling in response to WNT	112	8.17e-01	0.92100	0.04530	3.35e-02	0.030400	5.41e-01	5.79e-01
Semaphorin interactions	34	7.11e-01	0.87900	0.04430	-3.22e-02	0.030500	7.45e-01	7.59e-01
Protein folding	57	6.31e-01	0.82800	0.04400	-4.20e-02	0.013000	5.84e-01	8.65e-01
Autophagy	93	8.34e-01	0.92600	0.04360	2.43e-02	0.036200	6.87e-01	5.47e-01
RNA Polymerase III Chain Elongation	17	9.54e-01	0.97300	0.04310	-1.66e-02	-0.039700	9.05e-01	7.77e-01
Cyclin D associated events in G1	40	8.18e-01	0.92100	0.04260	2.24e-03	0.042500	9.80e-01	6.42e-01
G1 Phase	40	8.18e-01	0.92100	0.04260	2.24e-03	0.042500	9.80e-01	6.42e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	19	9.46e-01	0.97300	0.04240	1.48e-02	0.039800	9.11e-01	7.64e-01
Activation of gene expression by SREBF (SREBP)	34	8.26e-01	0.92300	0.04230	1.54e-03	-0.042200	9.88e-01	6.70e-01
Cellular response to chemical stress	137	3.43e-01	0.68300	0.04200	-3.89e-02	0.015800	4.33e-01	7.50e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	31	9.38e-01	0.97300	0.04140	-2.01e-02	-0.036300	8.47e-01	7.27e-01
HIV Transcription Elongation	31	9.38e-01	0.97300	0.04140	-2.01e-02	-0.036300	8.47e-01	7.27e-01
Tat-mediated elongation of the HIV-1 transcript	31	9.38e-01	0.97300	0.04140	-2.01e-02	-0.036300	8.47e-01	7.27e-01
Transcriptional regulation by RUNX1	118	4.25e-01	0.71800	0.04110	-1.37e-02	0.038800	7.98e-01	4.68e-01
Selective autophagy	48	8.78e-01	0.94900	0.04070	-3.82e-02	-0.013900	6.47e-01	8.68e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	41	8.09e-01	0.91600	0.04050	-1.50e-03	0.040500	9.87e-01	6.54e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	41	8.09e-01	0.91600	0.04050	-1.50e-03	0.040500	9.87e-01	6.54e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	41	8.09e-01	0.91600	0.04050	-1.50e-03	0.040500	9.87e-01	6.54e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	41	8.09e-01	0.91600	0.04050	-1.50e-03	0.040500	9.87e-01	6.54e-01
Signaling by NOTCH1 in Cancer	41	8.09e-01	0.91600	0.04050	-1.50e-03	0.040500	9.87e-01	6.54e-01
ESR-mediated signaling	110	6.93e-01	0.86700	0.04050	-3.94e-02	-0.009240	4.76e-01	8.67e-01
ATF4 activates genes in response to endoplasmic reticulum stress	23	8.95e-01	0.95200	0.04000	2.17e-04	-0.040000	9.99e-01	7.40e-01
Sphingolipid de novo biosynthesis	18	9.76e-01	0.98300	0.03950	-2.81e-02	-0.027900	8.37e-01	8.38e-01
PI Metabolism	58	8.60e-01	0.94100	0.03940	3.72e-02	0.013000	6.25e-01	8.65e-01
Keratan sulfate/keratin metabolism	18	9.76e-01	0.98300	0.03910	2.65e-02	0.028800	8.46e-01	8.33e-01
Gastrin-CREB signalling pathway via PKC and MAPK	11	9.27e-01	0.96900	0.03890	3.57e-02	-0.015600	8.38e-01	9.29e-01
Cytoprotection by HMOX1	42	8.18e-01	0.92100	0.03880	-1.80e-03	0.038700	9.84e-01	6.65e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	14	9.68e-01	0.98200	0.03870	1.41e-02	0.036000	9.27e-01	8.16e-01
CLEC7A (Dectin-1) induces NFAT activation	11	9.52e-01	0.97300	0.03860	2.31e-04	-0.038600	9.99e-01	8.24e-01
Signalling to ERKs	25	9.51e-01	0.97300	0.03840	1.64e-02	0.034700	8.87e-01	7.64e-01
G alpha (12/13) signalling events	33	9.25e-01	0.96900	0.03760	1.25e-02	0.035500	9.01e-01	7.25e-01
Adaptive Immune System	439	3.69e-01	0.71100	0.03750	1.23e-02	0.035500	6.62e-01	2.08e-01
Glycosphingolipid metabolism	25	8.56e-01	0.94100	0.03730	-3.45e-02	0.014200	7.65e-01	9.02e-01
Formation of HIV elongation complex in the absence of HIV Tat	32	9.60e-01	0.97800	0.03670	-2.24e-02	-0.029100	8.26e-01	7.76e-01
Macroautophagy	85	7.38e-01	0.89100	0.03650	2.58e-03	0.036400	9.67e-01	5.62e-01
Neutrophil degranulation	275	7.26e-01	0.89000	0.03650	-2.38e-02	-0.027600	5.00e-01	4.34e-01
Generic Transcription Pathway	746	4.64e-01	0.73800	0.03560	-2.50e-02	-0.025400	2.56e-01	2.48e-01
Inflammasomes	16	9.48e-01	0.97300	0.03510	3.50e-02	0.002510	8.09e-01	9.86e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	9.24e-01	0.96900	0.03510	3.33e-02	-0.011000	8.24e-01	9.41e-01
Synthesis of PIPs at the Golgi membrane	12	9.81e-01	0.98700	0.03500	-3.13e-02	-0.015600	8.51e-01	9.25e-01
Metabolism of porphyrins	15	9.32e-01	0.97300	0.03480	-3.41e-02	0.007090	8.19e-01	9.62e-01
Phosphorylation of the APC/C	15	9.13e-01	0.96300	0.03480	2.11e-02	-0.027600	8.87e-01	8.53e-01
RHOU GTPase cycle	28	8.67e-01	0.94300	0.03440	3.24e-02	-0.011500	7.67e-01	9.16e-01
Prolonged ERK activation events	13	9.72e-01	0.98300	0.03410	-3.28e-02	-0.009450	8.38e-01	9.53e-01
NoRC negatively regulates rRNA expression	41	9.53e-01	0.97300	0.03360	2.81e-02	0.018400	7.56e-01	8.39e-01
Signaling by Receptor Tyrosine Kinases	279	5.66e-01	0.79000	0.03350	9.26e-03	0.032100	7.92e-01	3.59e-01
Signaling by Insulin receptor	39	9.44e-01	0.97300	0.03280	-2.98e-02	-0.013700	7.48e-01	8.83e-01
Interferon gamma signaling	50	8.51e-01	0.93900	0.03240	-3.23e-02	0.000764	6.93e-01	9.93e-01
Sphingolipid metabolism	43	8.94e-01	0.95200	0.03210	-3.19e-02	-0.003440	7.18e-01	9.69e-01
mRNA Capping	25	8.81e-01	0.94900	0.03180	1.88e-02	-0.025600	8.71e-01	8.25e-01
Signaling by Nuclear Receptors	145	4.97e-01	0.75800	0.03170	-1.63e-02	0.027200	7.36e-01	5.74e-01
Signaling by TGF-beta Receptor Complex	68	7.40e-01	0.89100	0.03150	-2.91e-02	0.012000	6.78e-01	8.65e-01
Constitutive Signaling by EGFRvIII	10	9.74e-01	0.98300	0.03120	1.93e-03	0.031200	9.92e-01	8.65e-01
Signaling by EGFRvIII in Cancer	10	9.74e-01	0.98300	0.03120	1.93e-03	0.031200	9.92e-01	8.65e-01
TNFR2 non-canonical NF-kB pathway	62	9.50e-01	0.97300	0.03070	-2.26e-02	-0.020800	7.58e-01	7.78e-01
Extra-nuclear estrogen signaling	47	9.23e-01	0.96800	0.02980	2.88e-02	0.007780	7.33e-01	9.27e-01
SHC1 events in ERBB2 signaling	11	9.65e-01	0.98100	0.02940	-2.89e-02	0.005430	8.68e-01	9.75e-01
Glutathione conjugation	18	9.45e-01	0.97300	0.02940	2.90e-02	-0.004340	8.31e-01	9.75e-01
RAF/MAP kinase cascade	147	6.78e-01	0.85300	0.02930	2.92e-02	-0.000900	5.42e-01	9.85e-01
Signalling to RAS	12	9.69e-01	0.98200	0.02880	-2.87e-02	0.001090	8.63e-01	9.95e-01
Activation of BAD and translocation to mitochondria	14	9.47e-01	0.97300	0.02840	-2.50e-02	0.013500	8.71e-01	9.30e-01
RNA Polymerase III Transcription Termination	20	9.87e-01	0.99000	0.02770	-1.97e-02	-0.019500	8.79e-01	8.80e-01
Negative regulation of MAPK pathway	35	9.68e-01	0.98200	0.02770	2.42e-02	0.013400	8.04e-01	8.91e-01
Selenoamino acid metabolism	76	8.97e-01	0.95200	0.02720	-7.00e-03	-0.026300	9.16e-01	6.92e-01
RHOA GTPase cycle	83	8.58e-01	0.94100	0.02700	-2.68e-02	-0.002780	6.73e-01	9.65e-01
FCGR3A-mediated IL10 synthesis	19	9.37e-01	0.97300	0.02660	1.34e-02	-0.022900	9.19e-01	8.63e-01
Nervous system development	285	8.44e-01	0.93600	0.02510	-2.02e-02	-0.014900	5.60e-01	6.68e-01
Formation of the Early Elongation Complex	25	9.84e-01	0.98800	0.02500	1.37e-02	0.020900	9.06e-01	8.57e-01
Formation of the HIV-1 Early Elongation Complex	25	9.84e-01	0.98800	0.02500	1.37e-02	0.020900	9.06e-01	8.57e-01
Axon guidance	275	8.64e-01	0.94200	0.02470	-1.63e-02	-0.018500	6.44e-01	6.00e-01
Mitochondrial biogenesis	52	8.58e-01	0.94100	0.02450	2.06e-02	-0.013300	7.98e-01	8.68e-01
Synthesis of PC	21	9.65e-01	0.98100	0.02440	2.44e-02	0.000723	8.46e-01	9.95e-01
Signaling by MET	37	9.70e-01	0.98200	0.02370	-2.19e-02	-0.009180	8.18e-01	9.23e-01
Innate Immune System	563	6.16e-01	0.82200	0.02350	-2.21e-02	-0.007920	3.78e-01	7.52e-01
Glycogen storage diseases	10	9.89e-01	0.99100	0.02350	5.68e-03	0.022800	9.75e-01	9.01e-01
Leishmania infection	103	9.53e-01	0.97300	0.02300	1.53e-02	0.017200	7.89e-01	7.64e-01
Signaling by Rho GTPases	407	5.41e-01	0.77800	0.02230	8.74e-04	-0.022300	9.76e-01	4.46e-01
Factors involved in megakaryocyte development and platelet production	82	9.51e-01	0.97300	0.02190	-1.95e-02	-0.009940	7.61e-01	8.77e-01
Post-translational modification: synthesis of GPI-anchored proteins	29	9.36e-01	0.97300	0.02180	1.88e-02	-0.011000	8.61e-01	9.19e-01
MHC class II antigen presentation	66	9.15e-01	0.96300	0.02140	-2.14e-02	-0.000212	7.64e-01	9.98e-01
Metabolism of carbohydrates	171	9.22e-01	0.96800	0.02040	-1.03e-02	-0.017600	8.18e-01	6.92e-01
EPH-Ephrin signaling	53	9.36e-01	0.97300	0.01950	1.28e-03	-0.019500	9.87e-01	8.06e-01
NRAGE signals death through JNK	24	9.73e-01	0.98300	0.01890	1.88e-02	-0.000925	8.73e-01	9.94e-01
Immune System	1056	5.01e-01	0.76000	0.01850	3.89e-03	0.018100	8.36e-01	3.35e-01
Post-translational protein modification	855	7.89e-01	0.91600	0.01840	-1.22e-02	-0.013800	5.55e-01	5.05e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	419	6.35e-01	0.83000	0.01660	4.40e-03	-0.016000	8.79e-01	5.78e-01
Keratan sulfate biosynthesis	14	9.91e-01	0.99200	0.01660	2.46e-03	0.016400	9.87e-01	9.15e-01
Ub-specific processing proteases	128	9.48e-01	0.97300	0.01650	1.54e-02	0.006030	7.64e-01	9.06e-01
Developmental Biology	429	8.91e-01	0.95200	0.01620	-8.75e-03	-0.013600	7.59e-01	6.32e-01
MAPK1/MAPK3 signaling	152	8.23e-01	0.92200	0.01600	1.17e-02	-0.010800	8.04e-01	8.19e-01
MAPK family signaling cascades	176	8.98e-01	0.95200	0.01400	6.51e-04	-0.013900	9.88e-01	7.51e-01
FLT3 Signaling	27	9.92e-01	0.99200	0.01340	-1.27e-02	-0.004310	9.09e-01	9.69e-01
Deubiquitination	189	8.85e-01	0.95100	0.01220	1.14e-02	-0.004420	7.89e-01	9.17e-01
Class I MHC mediated antigen processing & presentation	265	8.88e-01	0.95200	0.01220	-3.00e-04	0.012200	9.93e-01	7.35e-01
Interleukin-12 family signaling	41	9.88e-01	0.99100	0.00975	5.48e-05	-0.009750	1.00e+00	9.14e-01
Metabolism	1153	6.72e-01	0.85100	0.00955	3.03e-03	-0.009060	8.67e-01	6.17e-01

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Detailed Gene set reports

Negative regulation of NMDA receptor-mediated neuronal transmission

Negative regulation of NMDA receptor-mediated neuronal transmission

metric	value
setSize	11
pMANOVA	0.00498
p.adjustMANOVA	0.114
s.dist	0.713
s.wholegene	0.565
s.promoter	0.435
p.wholegene	0.00118
p.promoter	0.0126

Top 20 genes

Gene	wholegene	promoter
CAMK1	912	855.0
GRIN1	824	0.5
GRIN2D	642	0.5
CAMK2G	489	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CALM1	-763	-817.0
CAMK1	912	855.0
CAMK2D	-4472	-6176.0
CAMK2G	489	0.5
CAMK4	-1335	-481.0
DLG1	-491	633.0
DLG2	334	-8562.0
DLG4	-7443	-3314.0
GRIN1	824	0.5
GRIN2D	642	0.5
PPM1F	-1963	-2994.0

---

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Purine catabolism

Purine catabolism

metric	value
setSize	10
pMANOVA	0.0231
p.adjustMANOVA	0.228
s.dist	0.654
s.wholegene	-0.448
s.promoter	-0.476
p.wholegene	0.0141
p.promoter	0.00917

Top 20 genes

Gene	wholegene	promoter
NT5C	-8271	-8902.0
PNP	-8311	-8273.0
ITPA	-8021	-7113.0
NUDT15	-6602	-8164.0
NT5C2	-6792	-6272.0
NUDT9	-5907	-5480.0
NUDT16	-3289	-7893.0
NUDT18	-7690	-2807.0
NUDT5	-4334	-4949.0
NUDT1	-2642	-3852.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ITPA	-8021	-7113.0
NT5C	-8271	-8902.0
NT5C2	-6792	-6272.0
NUDT1	-2642	-3852.5
NUDT15	-6602	-8164.0
NUDT16	-3289	-7893.0
NUDT18	-7690	-2807.0
NUDT5	-4334	-4949.0
NUDT9	-5907	-5480.0
PNP	-8311	-8273.0

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Long-term potentiation

Long-term potentiation

metric	value
setSize	10
pMANOVA	0.00554
p.adjustMANOVA	0.115
s.dist	0.645
s.wholegene	0.571
s.promoter	0.301
p.wholegene	0.00178
p.promoter	0.0989

Top 20 genes

Gene	wholegene	promoter
GRIN1	824	0.5
GRIN2D	642	0.5
CAMK2G	489	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CALM1	-763	-817.0
CAMK2D	-4472	-6176.0
CAMK2G	489	0.5
DLG1	-491	633.0
DLG2	334	-8562.0
DLG4	-7443	-3314.0
GRIN1	824	0.5
GRIN2D	642	0.5
NRGN	309	-3353.0
SRC	-1203	-3915.0

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p75NTR signals via NF-kB

p75NTR signals via NF-kB

metric	value
setSize	11
pMANOVA	0.0199
p.adjustMANOVA	0.222
s.dist	0.636
s.wholegene	-0.461
s.promoter	-0.439
p.wholegene	0.00819
p.promoter	0.0118

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
MYD88	-8431	-8048.0
NFKBIA	-7652	-8516.0
SQSTM1	-8646	-6839.0
TRAF6	-7811	-7283.0
UBB	-7572	-7240.0
IKBKB	-4652	-7351.0
PRKCI	-4357	-5240.0
UBA52	-2489	-634.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
IKBKB	-4652	-7351.0
MYD88	-8431	-8048.0
NFKBIA	-7652	-8516.0
PRKCI	-4357	-5240.0
RELA	-358	353.0
RPS27A	-7906	-8712.5
SQSTM1	-8646	-6839.0
TRAF6	-7811	-7283.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0

---

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Ras activation upon Ca2+ influx through NMDA receptor

Ras activation upon Ca2+ influx through NMDA receptor

metric	value
setSize	10
pMANOVA	0.0556
p.adjustMANOVA	0.37
s.dist	0.568
s.wholegene	0.426
s.promoter	0.376
p.wholegene	0.0196
p.promoter	0.0396

Top 20 genes

Gene	wholegene	promoter
GRIN1	824	0.5
GRIN2D	642	0.5
CAMK2G	489	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CALM1	-763	-817.0
CAMK2D	-4472	-6176.0
CAMK2G	489	0.5
DLG1	-491	633.0
DLG2	334	-8562.0
DLG4	-7443	-3314.0
GRIN1	824	0.5
GRIN2D	642	0.5
HRAS	-367	-508.0
KRAS	-7627	-3095.0

---

---

Meiotic recombination

Meiotic recombination

metric	value
setSize	19
pMANOVA	0.00357
p.adjustMANOVA	0.104
s.dist	0.561
s.wholegene	-0.345
s.promoter	-0.443
p.wholegene	0.0093
p.promoter	0.000838

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
PSMC3IP	-8181	-8067.0
MND1	-8398	-7741.0
BLM	-8137	-7501.0
MSH5	-6613	-8789.0
TOP3A	-7966	-7020.5
CDK4	-7442	-6073.0
RPA3	-4170	-6328.0
MLH3	-4017	-5573.0
H2AFX	-4519	-3494.0
DMC1	-3076	-4318.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
CDK2	421	-3323.5
CDK4	-7442	-6073.0
DMC1	-3076	-4318.0
H2AFX	-4519	-3494.0
MLH3	-4017	-5573.0
MND1	-8398	-7741.0
MSH5	-6613	-8789.0
NBN	-1031	-1658.0
PSMC3IP	-8181	-8067.0
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RBBP8	-8371	-8270.0
RPA1	99	-3377.5
RPA3	-4170	-6328.0
TOP3A	-7966	-7020.5

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---

Resolution of D-loop Structures through Holliday Junction Intermediates

Resolution of D-loop Structures through Holliday Junction Intermediates

metric	value
setSize	24
pMANOVA	0.000638
p.adjustMANOVA	0.0586
s.dist	0.547
s.wholegene	-0.452
s.promoter	-0.308
p.wholegene	0.000126
p.promoter	0.00901

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
MUS81	-8355	-8759.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
GEN1	-7388	-8523.5
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
XRCC3	-2802	-7805.5
EME2	-8426	-2554.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
EME1	-3386	-2531.5
RAD50	-2420	-1967.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EME1	-3386	-2531.5
EME2	-8426	-2554.5
EXO1	-8207	-6078.0
GEN1	-7388	-8523.5
KAT5	-8805	-8198.0
MUS81	-8355	-8759.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0
XRCC3	-2802	-7805.5

---

---

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function

metric	value
setSize	19
pMANOVA	0.00224
p.adjustMANOVA	0.075
s.dist	0.538
s.wholegene	-0.459
s.promoter	-0.282
p.wholegene	0.000535
p.promoter	0.0336

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0
BARD1	-4220	-363.0
PALB2	-394	-839.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function

metric	value
setSize	19
pMANOVA	0.00224
p.adjustMANOVA	0.075
s.dist	0.538
s.wholegene	-0.459
s.promoter	-0.282
p.wholegene	0.000535
p.promoter	0.0336

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0
BARD1	-4220	-363.0
PALB2	-394	-839.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

metric	value
setSize	19
pMANOVA	0.00224
p.adjustMANOVA	0.075
s.dist	0.538
s.wholegene	-0.459
s.promoter	-0.282
p.wholegene	0.000535
p.promoter	0.0336

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0
BARD1	-4220	-363.0
PALB2	-394	-839.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

metric	value
setSize	19
pMANOVA	0.00224
p.adjustMANOVA	0.075
s.dist	0.538
s.wholegene	-0.459
s.promoter	-0.282
p.wholegene	0.000535
p.promoter	0.0336

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0
BARD1	-4220	-363.0
PALB2	-394	-839.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Impaired BRCA2 binding to PALB2

Impaired BRCA2 binding to PALB2

metric	value
setSize	19
pMANOVA	0.00224
p.adjustMANOVA	0.075
s.dist	0.538
s.wholegene	-0.459
s.promoter	-0.282
p.wholegene	0.000535
p.promoter	0.0336

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0
BARD1	-4220	-363.0
PALB2	-394	-839.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Resolution of D-Loop Structures

Resolution of D-Loop Structures

metric	value
setSize	25
pMANOVA	0.000503
p.adjustMANOVA	0.0586
s.dist	0.538
s.wholegene	-0.449
s.promoter	-0.296
p.wholegene	0.000101
p.promoter	0.0105

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
MUS81	-8355	-8759.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
GEN1	-7388	-8523.5
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RTEL1	-5850	-4022.0
XRCC3	-2802	-7805.5
EME2	-8426	-2554.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
EME1	-3386	-2531.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EME1	-3386	-2531.5
EME2	-8426	-2554.5
EXO1	-8207	-6078.0
GEN1	-7388	-8523.5
KAT5	-8805	-8198.0
MUS81	-8355	-8759.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
RTEL1	-5850	-4022.0
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0
XRCC3	-2802	-7805.5

---

---

Potassium Channels

Potassium Channels

metric	value
setSize	23
pMANOVA	0.00478
p.adjustMANOVA	0.112
s.dist	0.514
s.wholegene	0.351
s.promoter	0.374
p.wholegene	0.00355
p.promoter	0.00189

Top 20 genes

Gene	wholegene	promoter
KCNA3	398	592
GNG2	191	620

Click HERE to show all gene set members

All member genes

	wholegene	promoter
GABBR1	-3684	0.5
GNB1	-1549	-4107.0
GNB2	-6810	-8449.0
GNB5	-3699	-4674.0
GNG12	-564	0.5
GNG2	191	620.0
GNG3	-5175	-5234.0
GNG4	-3925	869.0
GNG5	-2328	-3127.5
GNGT2	-1462	0.5
HCN3	-6445	-5548.0
KCNA3	398	592.0
KCNAB2	-1766	-4418.0
KCNC4	-1138	0.5
KCNG3	-4504	0.5
KCNH4	834	-876.0
KCNJ11	-3910	-4765.0
KCNK6	-1342	-664.0
KCNMB4	-2815	-1430.0
KCNN4	-87	-5352.0
KCNQ1	-508	848.5
KCNQ4	-1988	-4242.0
KCNQ5	352	-497.0

---

---

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

metric	value
setSize	21
pMANOVA	0.00369
p.adjustMANOVA	0.105
s.dist	0.513
s.wholegene	-0.422
s.promoter	-0.291
p.wholegene	0.000818
p.promoter	0.0209

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
WRN	-8468	-4029.5
RTEL1	-5850	-4022.0
XRCC3	-2802	-7805.5
RAD51AP1	-4995	-3956.5
XRCC2	-4263	-4285.0
RAD50	-2420	-1967.0
NBN	-1031	-1658.0
BARD1	-4220	-363.0
PALB2	-394	-839.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RBBP8	-8371	-8270.0
RMI1	-8816	-7389.5
RTEL1	-5850	-4022.0
TOP3A	-7966	-7020.5
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0
XRCC3	-2802	-7805.5

---

---

RORA activates gene expression

RORA activates gene expression

metric	value
setSize	11
pMANOVA	0.0135
p.adjustMANOVA	0.19
s.dist	0.511
s.wholegene	0.472
s.promoter	0.195
p.wholegene	0.00673
p.promoter	0.262

Top 20 genes

Gene	wholegene	promoter

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CHD9	-7322	-7294.0
CPT1A	-534	-2206.0
CREBBP	-1252	0.5
EP300	564	-1183.0
MED1	-333	774.0
NCOA2	-561	-1797.0
NCOA6	-929	-4202.0
RORA	-454	-3351.0
SREBF1	-765	-2952.0
TBL1XR1	-2204	-6662.0
TGS1	-4502	-4916.5

---

---

Impaired BRCA2 binding to RAD51

Impaired BRCA2 binding to RAD51

metric	value
setSize	30
pMANOVA	0.00173
p.adjustMANOVA	0.075
s.dist	0.489
s.wholegene	-0.363
s.promoter	-0.327
p.wholegene	0.00058
p.promoter	0.00196

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
ATR	-8756	-8697.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RFC3	-8297	-8030.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
RFC5	-6582	-8619.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
RAD1	-7303	-6683.5
RFC2	-7089	-5672.0
RAD9B	-4455	-7770.5
WRN	-8468	-4029.5
RAD17	-5641	-5393.5
RPA3	-4170	-6328.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
ATR	-8756	-8697.0
ATRIP	-3341	-2471.0
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
HUS1	-3666	-5490.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
RAD1	-7303	-6683.5
RAD17	-5641	-5393.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD9A	-1036	-3132.0
RAD9B	-4455	-7770.5
RBBP8	-8371	-8270.0
RFC2	-7089	-5672.0
RFC3	-8297	-8030.0
RFC4	-62	-456.0
RFC5	-6582	-8619.0
RMI1	-8816	-7389.5
RPA1	99	-3377.5
RPA3	-4170	-6328.0
TOP3A	-7966	-7020.5
TOPBP1	-3780	-3108.0
WRN	-8468	-4029.5

---

---

IKK complex recruitment mediated by RIP1

IKK complex recruitment mediated by RIP1

metric	value
setSize	17
pMANOVA	0.0242
p.adjustMANOVA	0.231
s.dist	0.482
s.wholegene	-0.296
s.promoter	-0.38
p.wholegene	0.035
p.promoter	0.00663

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
TRAF6	-7811	-7283.0
UBE2D2	-8285	-6859.0
UBB	-7572	-7240.0
CHUK	-6473	-8055.0
TICAM1	-7341	-6700.0
RIPK3	-5056	-7627.0
UBE2V1	-6883	-5429.0
IKBKB	-4652	-7351.0
BIRC2	-3965	-5780.0
UBE2D1	-3565	-4090.0
UBE2D3	-6133	-1554.5
UBE2N	-2327	-4053.0
BIRC3	-2410	-3734.0
SARM1	-685	-6652.0
UBA52	-2489	-634.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
BIRC2	-3965	-5780.0
BIRC3	-2410	-3734.0
CHUK	-6473	-8055.0
IKBKB	-4652	-7351.0
RIPK3	-5056	-7627.0
RPS27A	-7906	-8712.5
SARM1	-685	-6652.0
TICAM1	-7341	-6700.0
TRAF6	-7811	-7283.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0
UBE2D1	-3565	-4090.0
UBE2D2	-8285	-6859.0
UBE2D3	-6133	-1554.5
UBE2N	-2327	-4053.0
UBE2V1	-6883	-5429.0

---

---

Glycogen synthesis

Glycogen synthesis

metric	value
setSize	11
pMANOVA	0.105
p.adjustMANOVA	0.456
s.dist	0.48
s.wholegene	-0.358
s.promoter	-0.319
p.wholegene	0.0396
p.promoter	0.0669

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
PGM2	-8404	-8095.0
UGP2	-7123	-8608.0
UBB	-7572	-7240.0
PGM1	-4843	-7755.0
PGM2L1	-8210	-4508.0
GYS1	-5805	-5628.5
GYG1	-2893	-2723.0
UBA52	-2489	-634.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
GYG1	-2893	-2723.0
GYS1	-5805	-5628.5
NHLRC1	893	856.0
PGM1	-4843	-7755.0
PGM2	-8404	-8095.0
PGM2L1	-8210	-4508.0
RPS27A	-7906	-8712.5
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0
UGP2	-7123	-8608.0

---

---

A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis

metric	value
setSize	10
pMANOVA	0.0992
p.adjustMANOVA	0.446
s.dist	0.478
s.wholegene	0.393
s.promoter	0.273
p.wholegene	0.0316
p.promoter	0.135

Top 20 genes

Gene	wholegene	promoter
B4GALT7	255	518.0
B3GALT6	148	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
AGRN	-1568	-2498.0
B3GALT6	148	0.5
B3GAT2	-972	-2302.0
B3GAT3	-8534	-8288.0
B4GALT7	255	518.0
BCAN	-276	-3822.0
GPC2	-990	-675.5
SDC4	-888	-970.0
XYLT1	56	-1655.0
XYLT2	-7758	-7207.0

---

---

SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy

metric	value
setSize	10
pMANOVA	0.134
p.adjustMANOVA	0.491
s.dist	0.465
s.wholegene	-0.29
s.promoter	-0.363
p.wholegene	0.112
p.promoter	0.0467

Top 20 genes

Gene	wholegene	promoter
VPS39	-6547	-8119.0
UVRAG	-5739	-7478.0
VPS18	-5184	-7033.0
VPS41	-6355	-5652.0
VPS33A	-6435	-5185.0
VPS16	-5461	-6035.5
VPS11	-4770	-5056.0
MAP1LC3B	-4740	-4785.0
VPS45	-3644	-5497.0
TUFM	-5222	-3334.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
MAP1LC3B	-4740	-4785.0
TUFM	-5222	-3334.0
UVRAG	-5739	-7478.0
VPS11	-4770	-5056.0
VPS16	-5461	-6035.5
VPS18	-5184	-7033.0
VPS33A	-6435	-5185.0
VPS39	-6547	-8119.0
VPS41	-6355	-5652.0
VPS45	-3644	-5497.0

---

---

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

metric	value
setSize	25
pMANOVA	0.00714
p.adjustMANOVA	0.135
s.dist	0.458
s.wholegene	-0.362
s.promoter	-0.281
p.wholegene	0.00175
p.promoter	0.0151

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RNF111	-8482	-8837.0
SP1	-8349	-8826.0
TGIF2	-8817	-8261.0
TGIF1	-8448	-8557.0
RPS27A	-7906	-8712.5
CCNC	-7511	-8654.0
CCNT1	-6909	-8020.0
UBB	-7572	-7240.0
JUNB	-7862	-6441.0
HDAC1	-6923	-7076.0
MEN1	-5818	-7703.0
RBL1	-5564	-6170.0
MAPK3	-5975	-5593.0
SMAD3	-5251	-5683.0
CDK9	-6589	-3962.0
CCNK	-4450	-3080.5
E2F5	-4994	-2676.0
E2F4	-3676	-3013.0
MAPK1	-3035	-3485.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CCNC	-7511	-8654.0
CCNK	-4450	-3080.5
CCNT1	-6909	-8020.0
CDK8	-1412	-1012.0
CDK9	-6589	-3962.0
E2F4	-3676	-3013.0
E2F5	-4994	-2676.0
HDAC1	-6923	-7076.0
JUNB	-7862	-6441.0
MAPK1	-3035	-3485.0
MAPK3	-5975	-5593.0
MEN1	-5818	-7703.0
RBL1	-5564	-6170.0
RNF111	-8482	-8837.0
RPS27A	-7906	-8712.5
SMAD2	-2715	-3070.0
SMAD3	-5251	-5683.0
SMAD7	-4015	0.5
SP1	-8349	-8826.0
TFDP1	-353	0.5
TGIF1	-8448	-8557.0
TGIF2	-8817	-8261.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0

---

---

Signaling by Leptin

Signaling by Leptin

metric	value
setSize	10
pMANOVA	0.0284
p.adjustMANOVA	0.246
s.dist	0.455
s.wholegene	0.145
s.promoter	0.431
p.wholegene	0.427
p.promoter	0.0182

Top 20 genes

Gene	wholegene	promoter

Click HERE to show all gene set members

All member genes

	wholegene	promoter
IRS1	-5797	-7564.0
IRS2	-331	875.0
JAK2	-1390	0.5
LEPR	-218	-443.5
PTPN11	-8014	-6287.0
SH2B1	-2205	-1515.0
SOCS3	-5725	652.0
STAT3	-4597	-2825.0
STAT5A	-3380	-929.0
STAT5B	-1042	-1073.0

---

---

Mitochondrial tRNA aminoacylation

Mitochondrial tRNA aminoacylation

metric	value
setSize	17
pMANOVA	0.0369
p.adjustMANOVA	0.295
s.dist	0.446
s.wholegene	-0.263
s.promoter	-0.36
p.wholegene	0.0608
p.promoter	0.0102

Top 20 genes

Gene	wholegene	promoter
HARS2	-8377	-7957.5
NARS2	-7169	-8388.0
EARS2	-7757	-7568.5
MARS2	-7399	-7890.0
IARS2	-7809	-7183.0
DARS2	-6588	-8101.5
RARS2	-7172	-7219.5
AARS2	-6136	-6759.0
PARS2	-6271	-5702.0
SARS2	-5551	-5543.5
FARS2	-3812	-6024.5
YARS2	-4097	-4648.0
PPA2	-4142	-3617.0
WARS2	-3483	-1872.0
TARS2	-3919	-1190.0
CARS2	-472	-7259.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
AARS2	-6136	-6759.0
CARS2	-472	-7259.0
DARS2	-6588	-8101.5
EARS2	-7757	-7568.5
FARS2	-3812	-6024.5
HARS2	-8377	-7957.5
IARS2	-7809	-7183.0
MARS2	-7399	-7890.0
NARS2	-7169	-8388.0
PARS2	-6271	-5702.0
PPA2	-4142	-3617.0
RARS2	-7172	-7219.5
SARS2	-5551	-5543.5
TARS2	-3919	-1190.0
VARS2	512	-1656.0
WARS2	-3483	-1872.0
YARS2	-4097	-4648.0

---

---

DCC mediated attractive signaling

DCC mediated attractive signaling

metric	value
setSize	11
pMANOVA	0.00642
p.adjustMANOVA	0.127
s.dist	0.443
s.wholegene	0.437
s.promoter	0.0698
p.wholegene	0.012
p.promoter	0.689

Top 20 genes

Gene	wholegene	promoter
ABLIM2	123	777.0
NTN1	728	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ABLIM1	-2748	-5453.0
ABLIM2	123	777.0
CDC42	-4865	-8026.0
FYN	-6192	-7876.0
NCK1	-4434	-3899.0
NTN1	728	0.5
PTK2	260	-5149.0
RAC1	-51	-2453.0
SRC	-1203	-3915.0
TRIO	583	-2214.0
WASL	-2365	-2367.0

---

---

Pexophagy

Pexophagy

metric	value
setSize	11
pMANOVA	0.137
p.adjustMANOVA	0.491
s.dist	0.442
s.wholegene	-0.344
s.promoter	-0.277
p.wholegene	0.0481
p.promoter	0.112

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
SQSTM1	-8646	-6839.0
UBB	-7572	-7240.0
NBR1	-6664	-5500.0
MAP1LC3B	-4740	-4785.0
PEX5	-2552	-2630.0
USP30	-2351	-2713.0
EPAS1	-1810	-2778.0
UBA52	-2489	-634.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
EPAS1	-1810	-2778.0
MAP1LC3B	-4740	-4785.0
NBR1	-6664	-5500.0
PEX5	-2552	-2630.0
RPS27A	-7906	-8712.5
SQSTM1	-8646	-6839.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0
USP30	-2351	-2713.0

---

---

Signaling by BMP

Signaling by BMP

metric	value
setSize	14
pMANOVA	0.00429
p.adjustMANOVA	0.112
s.dist	0.442
s.wholegene	0.108
s.promoter	0.428
p.wholegene	0.485
p.promoter	0.00553

Top 20 genes

Gene	wholegene	promoter
SMURF2	931	883.0
BMPR1A	209	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ACVR2A	-5600	0.5
ACVR2B	-3072	-908.5
BMPR1A	209	0.5
BMPR2	-2407	0.5
SKI	-485	-1033.0
SMAD1	-2823	-1553.0
SMAD5	-7956	-5681.5
SMAD6	-7190	-4422.0
SMAD7	-4015	0.5
SMURF1	-52	-2491.0
SMURF2	931	883.0
UBE2D1	-3565	-4090.0
UBE2D3	-6133	-1554.5
ZFYVE16	-6183	-6129.0

---

---

Signaling by WNT in cancer

Signaling by WNT in cancer

metric	value
setSize	22
pMANOVA	0.0232
p.adjustMANOVA	0.228
s.dist	0.441
s.wholegene	0.308
s.promoter	0.316
p.wholegene	0.0123
p.promoter	0.0104

Top 20 genes

Gene	wholegene	promoter
FZD8	701	717

Click HERE to show all gene set members

All member genes

	wholegene	promoter
APC	-2727.0	-4548.0
AXIN1	94.0	-2143.0
CSNK1A1	-940.0	-2210.0
CTBP1	-5948.0	0.5
CTNNB1	-3595.0	-6204.0
FZD5	413.0	-735.0
FZD6	-3460.0	-3925.0
FZD8	701.0	717.0
GSK3B	-755.0	-1568.0
LRP5	-750.0	0.5
LRP6	-3566.0	-954.0
PPP2CA	-7573.0	-6314.0
PPP2CB	-3311.0	-1685.0
PPP2R1B	-1897.0	-1211.0
PPP2R5A	-2917.0	-5091.0
PPP2R5B	-5074.0	-6090.0
PPP2R5C	-4305.0	-3931.0
PPP2R5D	-3106.0	-3194.0
PPP2R5E	-2200.0	-1172.0
TNKS	0.5	-2848.0
TNKS2	-3234.0	-2298.0
WNT3A	-152.0	823.0

---

---

Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand

metric	value
setSize	10
pMANOVA	0.178
p.adjustMANOVA	0.519
s.dist	0.439
s.wholegene	-0.29
s.promoter	-0.33
p.wholegene	0.112
p.promoter	0.0711

Top 20 genes

Gene	wholegene	promoter
FAS	-8535	-8683.5
CFLAR	-7741	-7775.0
TRADD	-8279	-6427.5
TICAM1	-7341	-6700.0
TNFRSF10B	-5107	-5205.0
TRAF2	-5280	-4778.0
TNFRSF10A	-4056	-6070.0
CASP8	-3055	-6169.0
TNFSF10	-2740	-2568.0
FADD	-1948	-2144.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CASP8	-3055	-6169.0
CFLAR	-7741	-7775.0
FADD	-1948	-2144.0
FAS	-8535	-8683.5
TICAM1	-7341	-6700.0
TNFRSF10A	-4056	-6070.0
TNFRSF10B	-5107	-5205.0
TNFSF10	-2740	-2568.0
TRADD	-8279	-6427.5
TRAF2	-5280	-4778.0

---

---

Translesion Synthesis by POLH

Translesion Synthesis by POLH

metric	value
setSize	16
pMANOVA	0.0645
p.adjustMANOVA	0.379
s.dist	0.439
s.wholegene	-0.292
s.promoter	-0.327
p.wholegene	0.0433
p.promoter	0.0235

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
UFD1L	-8440	-8911.5
RPS27A	-7906	-8712.5
RFC3	-8297	-8030.0
RFC5	-6582	-8619.0
UBB	-7572	-7240.0
RFC2	-7089	-5672.0
VCP	-5992	-4870.0
RPA3	-4170	-6328.0
RCHY1	-5753	-4515.5
PCNA	-4533	-5027.0
NPLOC4	-3821	-5447.0
POLH	-5229	-3833.5
UBA52	-2489	-634.0
RFC4	-62	-456.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
NPLOC4	-3821	-5447.0
PCNA	-4533	-5027.0
POLH	-5229	-3833.5
RCHY1	-5753	-4515.5
RFC2	-7089	-5672.0
RFC3	-8297	-8030.0
RFC4	-62	-456.0
RFC5	-6582	-8619.0
RPA1	99	-3377.5
RPA3	-4170	-6328.0
RPS27A	-7906	-8712.5
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0
UFD1L	-8440	-8911.5
VCP	-5992	-4870.0

---

---

Signaling by Hippo

Signaling by Hippo

metric	value
setSize	10
pMANOVA	0.0811
p.adjustMANOVA	0.416
s.dist	0.438
s.wholegene	0.393
s.promoter	0.195
p.wholegene	0.0316
p.promoter	0.285

Top 20 genes

Gene	wholegene	promoter
CASP3	182.0	380.5
YWHAE	0.5	480.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CASP3	182.0	380.5
DVL2	-2037.0	-7556.0
LATS1	-3107.0	-1486.0
LATS2	-404.0	-1182.0
NPHP4	-1917.0	-2150.0
STK3	242.0	-3129.0
STK4	-795.0	-2036.0
TJP2	-5333.0	-5646.0
YWHAB	-7364.0	-8384.0
YWHAE	0.5	480.0

---

---

Activation of kainate receptors upon glutamate binding

Activation of kainate receptors upon glutamate binding

metric	value
setSize	15
pMANOVA	0.0767
p.adjustMANOVA	0.406
s.dist	0.437
s.wholegene	0.287
s.promoter	0.329
p.wholegene	0.0547
p.promoter	0.0272

Top 20 genes

Gene	wholegene	promoter
GNG2	191	620

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CALM1	-763	-817.0
DLG1	-491	633.0
DLG4	-7443	-3314.0
GNB1	-1549	-4107.0
GNB2	-6810	-8449.0
GNB5	-3699	-4674.0
GNG12	-564	0.5
GNG2	191	620.0
GNG3	-5175	-5234.0
GNG4	-3925	869.0
GNG5	-2328	-3127.5
GNGT2	-1462	0.5
NCALD	-3659	0.5
PLCB2	-1424	-7661.0
PLCB3	487	-933.0

---

---

TICAM1, RIP1-mediated IKK complex recruitment

TICAM1, RIP1-mediated IKK complex recruitment

metric	value
setSize	17
pMANOVA	0.0594
p.adjustMANOVA	0.372
s.dist	0.433
s.wholegene	-0.292
s.promoter	-0.32
p.wholegene	0.0372
p.promoter	0.0225

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
TRAF6	-7811	-7283.0
UBE2D2	-8285	-6859.0
UBB	-7572	-7240.0
CHUK	-6473	-8055.0
TICAM1	-7341	-6700.0
RIPK3	-5056	-7627.0
UBE2V1	-6883	-5429.0
IKBKB	-4652	-7351.0
BIRC2	-3965	-5780.0
UBE2D1	-3565	-4090.0
UBE2D3	-6133	-1554.5
UBE2N	-2327	-4053.0
BIRC3	-2410	-3734.0
UBA52	-2489	-634.0
TLR3	-389	-1577.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
BIRC2	-3965	-5780.0
BIRC3	-2410	-3734.0
CHUK	-6473	-8055.0
IKBKB	-4652	-7351.0
RIPK3	-5056	-7627.0
RPS27A	-7906	-8712.5
TICAM1	-7341	-6700.0
TLR3	-389	-1577.0
TRAF6	-7811	-7283.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0
UBE2D1	-3565	-4090.0
UBE2D2	-8285	-6859.0
UBE2D3	-6133	-1554.5
UBE2N	-2327	-4053.0
UBE2V1	-6883	-5429.0

---

---

Presynaptic phase of homologous DNA pairing and strand exchange

Presynaptic phase of homologous DNA pairing and strand exchange

metric	value
setSize	32
pMANOVA	0.00518
p.adjustMANOVA	0.115
s.dist	0.432
s.wholegene	-0.314
s.promoter	-0.297
p.wholegene	0.0021
p.promoter	0.00367

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
ATR	-8756	-8697.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RFC3	-8297	-8030.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
RFC5	-6582	-8619.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
RAD1	-7303	-6683.5
RFC2	-7089	-5672.0
RAD9B	-4455	-7770.5
WRN	-8468	-4029.5
RAD17	-5641	-5393.5
RPA3	-4170	-6328.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
ATR	-8756	-8697.0
ATRIP	-3341	-2471.0
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
CHEK1	399	-2304.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
HUS1	-3666	-5490.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
RAD1	-7303	-6683.5
RAD17	-5641	-5393.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD9A	-1036	-3132.0
RAD9B	-4455	-7770.5
RBBP8	-8371	-8270.0
RFC2	-7089	-5672.0
RFC3	-8297	-8030.0
RFC4	-62	-456.0
RFC5	-6582	-8619.0
RMI1	-8816	-7389.5
RPA1	99	-3377.5
RPA3	-4170	-6328.0
TOP3A	-7966	-7020.5
TOPBP1	-3780	-3108.0
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Negative regulation of FLT3

Negative regulation of FLT3

metric	value
setSize	10
pMANOVA	0.193
p.adjustMANOVA	0.539
s.dist	0.432
s.wholegene	-0.296
s.promoter	-0.315
p.wholegene	0.106
p.promoter	0.0848

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
FLT3LG	-8266	-8264.0
UBB	-7572	-7240.0
CBL	-4693	-5176.0
CSK	-3260	-6881.0
ABL2	-6277	-3394.0
SOCS2	-3804	-4505.0
SH2B3	-1263	-2434.0
UBA52	-2489	-634.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ABL2	-6277	-3394.0
CBL	-4693	-5176.0
CSK	-3260	-6881.0
FLT3LG	-8266	-8264.0
RPS27A	-7906	-8712.5
SH2B3	-1263	-2434.0
SOCS2	-3804	-4505.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0

---

---

Mucopolysaccharidoses

Mucopolysaccharidoses

metric	value
setSize	10
pMANOVA	0.154
p.adjustMANOVA	0.512
s.dist	0.429
s.wholegene	0.244
s.promoter	0.353
p.wholegene	0.181
p.promoter	0.0532

Top 20 genes

Gene	wholegene	promoter

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ARSB	-4224	-2116.0
GALNS	82	-739.5
GLB1	-3075	-2090.5
GNS	-2692	-4037.0
GUSB	-7601	-3581.0
HGSNAT	-5788	-1808.0
HYAL1	-124	0.5
IDUA	109	-1665.5
NAGLU	-3657	-5949.0
SGSH	-850	-971.5

---

---

Assembly and cell surface presentation of NMDA receptors

Assembly and cell surface presentation of NMDA receptors

metric	value
setSize	12
pMANOVA	0.143
p.adjustMANOVA	0.491
s.dist	0.429
s.wholegene	0.298
s.promoter	0.309
p.wholegene	0.0742
p.promoter	0.0637

Top 20 genes

Gene	wholegene	promoter
GRIN1	824	0.5
GRIN2D	642	0.5
CAMK2G	489	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
APBA1	254	-992.0
CAMK2D	-4472	-6176.0
CAMK2G	489	0.5
DLG1	-491	633.0
DLG2	334	-8562.0
DLG4	-7443	-3314.0
GRIN1	824	0.5
GRIN2D	642	0.5
KIF17	-4550	-1599.0
LIN7B	-6375	-4774.0
LIN7C	-6261	-5707.5
NBEA	-3184	346.0

---

---

Interleukin-10 signaling

Interleukin-10 signaling

metric	value
setSize	12
pMANOVA	0.14
p.adjustMANOVA	0.491
s.dist	0.425
s.wholegene	0.276
s.promoter	0.324
p.wholegene	0.0985
p.promoter	0.0521

Top 20 genes

Gene	wholegene	promoter
CCR1	767	768

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CCR1	767	768.0
CSF1	-423	-3126.0
ICAM1	-7163	-6745.0
IL10RA	-1168	-775.0
IL10RB	-3746	-3086.0
IL12A	-4602	-3564.0
JAK1	-1868	-838.0
STAT3	-4597	-2825.0
TNF	-1614	-1324.0
TNFRSF1A	-1871	0.5
TNFRSF1B	449	-3794.0
TYK2	-5705	-3971.0

---

---

tRNA Aminoacylation

tRNA Aminoacylation

metric	value
setSize	22
pMANOVA	0.0119
p.adjustMANOVA	0.175
s.dist	0.424
s.wholegene	-0.219
s.promoter	-0.363
p.wholegene	0.0753
p.promoter	0.00321

Top 20 genes

Gene	wholegene	promoter
HARS2	-8377	-7957.5
NARS2	-7169	-8388.0
EARS2	-7757	-7568.5
MARS2	-7399	-7890.0
FARSB	-7342	-7844.0
IARS2	-7809	-7183.0
DARS2	-6588	-8101.5
RARS2	-7172	-7219.5
AIMP2	-6616	-7587.5
AARS2	-6136	-6759.0
PARS2	-6271	-5702.0
SARS2	-5551	-5543.5
FARS2	-3812	-6024.5
YARS2	-4097	-4648.0
FARSA	-4014	-4442.0
PPA1	-4011	-3935.0
PPA2	-4142	-3617.0
WARS2	-3483	-1872.0
TARS2	-3919	-1190.0
CARS2	-472	-7259.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
AARS2	-6136	-6759.0
AIMP2	-6616	-7587.5
CARS2	-472	-7259.0
DARS2	-6588	-8101.5
EARS2	-7757	-7568.5
EEF1E1	341	-5514.0
FARS2	-3812	-6024.5
FARSA	-4014	-4442.0
FARSB	-7342	-7844.0
HARS2	-8377	-7957.5
IARS2	-7809	-7183.0
MARS2	-7399	-7890.0
NARS2	-7169	-8388.0
PARS2	-6271	-5702.0
PPA1	-4011	-3935.0
PPA2	-4142	-3617.0
RARS2	-7172	-7219.5
SARS2	-5551	-5543.5
TARS2	-3919	-1190.0
VARS2	512	-1656.0
WARS2	-3483	-1872.0
YARS2	-4097	-4648.0

---

---

Mitochondrial calcium ion transport

Mitochondrial calcium ion transport

metric	value
setSize	14
pMANOVA	0.101
p.adjustMANOVA	0.449
s.dist	0.423
s.wholegene	0.269
s.promoter	0.326
p.wholegene	0.0811
p.promoter	0.0347

Top 20 genes

Gene	wholegene	promoter

Click HERE to show all gene set members

All member genes

	wholegene	promoter
AFG3L2	-1405	-965.0
AKAP1	-2850	-2965.0
C2orf47	-2609	-3718.5
LETM1	-3440	-558.0
PARL	78	-539.0
PHB	-450	0.5
PHB2	-6474	-7976.5
PMPCB	100	-418.0
SLC8A3	122	-327.0
SPG7	-6695	-5019.0
STOML2	-722	-1249.0
VDAC1	-2775	369.0
VDAC3	-5368	-6667.0
YME1L1	-4738	-3986.5

---

---

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

metric	value
setSize	33
pMANOVA	0.00537
p.adjustMANOVA	0.115
s.dist	0.421
s.wholegene	-0.316
s.promoter	-0.278
p.wholegene	0.00169
p.promoter	0.00566

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
ATR	-8756	-8697.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RFC3	-8297	-8030.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
RFC5	-6582	-8619.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
RAD1	-7303	-6683.5
RFC2	-7089	-5672.0
RAD9B	-4455	-7770.5
WRN	-8468	-4029.5
RAD17	-5641	-5393.5
RPA3	-4170	-6328.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
ATR	-8756	-8697.0
ATRIP	-3341	-2471.0
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
HUS1	-3666	-5490.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD1	-7303	-6683.5
RAD17	-5641	-5393.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RAD9A	-1036	-3132.0
RAD9B	-4455	-7770.5
RBBP8	-8371	-8270.0
RFC2	-7089	-5672.0
RFC3	-8297	-8030.0
RFC4	-62	-456.0
RFC5	-6582	-8619.0
RMI1	-8816	-7389.5
RPA1	99	-3377.5
RPA3	-4170	-6328.0
TOP3A	-7966	-7020.5
TOPBP1	-3780	-3108.0
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

Diseases of DNA Double-Strand Break Repair

Diseases of DNA Double-Strand Break Repair

metric	value
setSize	33
pMANOVA	0.00537
p.adjustMANOVA	0.115
s.dist	0.421
s.wholegene	-0.316
s.promoter	-0.278
p.wholegene	0.00169
p.promoter	0.00566

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
ATR	-8756	-8697.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RFC3	-8297	-8030.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
BLM	-8137	-7501.0
RFC5	-6582	-8619.0
TOP3A	-7966	-7020.5
EXO1	-8207	-6078.0
RAD1	-7303	-6683.5
RFC2	-7089	-5672.0
RAD9B	-4455	-7770.5
WRN	-8468	-4029.5
RAD17	-5641	-5393.5
RPA3	-4170	-6328.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
ATR	-8756	-8697.0
ATRIP	-3341	-2471.0
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
DNA2	-8799	-7266.0
EXO1	-8207	-6078.0
HUS1	-3666	-5490.0
KAT5	-8805	-8198.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
RAD1	-7303	-6683.5
RAD17	-5641	-5393.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RAD9A	-1036	-3132.0
RAD9B	-4455	-7770.5
RBBP8	-8371	-8270.0
RFC2	-7089	-5672.0
RFC3	-8297	-8030.0
RFC4	-62	-456.0
RFC5	-6582	-8619.0
RMI1	-8816	-7389.5
RPA1	99	-3377.5
RPA3	-4170	-6328.0
TOP3A	-7966	-7020.5
TOPBP1	-3780	-3108.0
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0

---

---

RHO GTPases activate CIT

RHO GTPases activate CIT

metric	value
setSize	14
pMANOVA	0.107
p.adjustMANOVA	0.459
s.dist	0.42
s.wholegene	-0.273
s.promoter	-0.319
p.wholegene	0.0766
p.promoter	0.0387

Top 20 genes

Gene	wholegene	promoter
RHOA	-8824	-8845.5
PPP1R12A	-8623	-8747.0
KIF14	-8497	-8455.0
CDKN1B	-7908	-6833.0
MYL6	-7416	-7079.0
RHOB	-7059	-4872.0
DLG4	-7443	-3314.0
CIT	-3345	-7187.0
MYH10	-3654	-5399.0
PPP1R12B	-1776	-8133.0
MYH9	-2758	-3866.0
PPP1CB	-4570	-1680.0
PRC1	-2641	-1532.0
RAC1	-51	-2453.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CDKN1B	-7908	-6833.0
CIT	-3345	-7187.0
DLG4	-7443	-3314.0
KIF14	-8497	-8455.0
MYH10	-3654	-5399.0
MYH9	-2758	-3866.0
MYL6	-7416	-7079.0
PPP1CB	-4570	-1680.0
PPP1R12A	-8623	-8747.0
PPP1R12B	-1776	-8133.0
PRC1	-2641	-1532.0
RAC1	-51	-2453.0
RHOA	-8824	-8845.5
RHOB	-7059	-4872.0

---

---

Defects in vitamin and cofactor metabolism

Defects in vitamin and cofactor metabolism

metric	value
setSize	16
pMANOVA	0.0673
p.adjustMANOVA	0.382
s.dist	0.418
s.wholegene	-0.335
s.promoter	-0.25
p.wholegene	0.0204
p.promoter	0.0833

Top 20 genes

Gene	wholegene	promoter
CD320	-8191	-8310.0
MTR	-8115	-7974.0
MMADHC	-7917	-8068.0
ABCD4	-7770	-7910.0
MMAB	-7121	-6964.5
MCCC1	-7955	-6003.0
BTD	-7038	-6765.5
HLCS	-7489	-4480.0
MCCC2	-6852	-4695.0
PC	-4126	-5730.0
ACACA	-4965	-3368.0
MMAA	-3750	-3991.0
MMACHC	-4312	-2830.5
LMBRD1	-1669	-4092.0
PCCB	-2116	-2355.0
MTRR	-666	-627.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ABCD4	-7770	-7910.0
ACACA	-4965	-3368.0
BTD	-7038	-6765.5
CD320	-8191	-8310.0
HLCS	-7489	-4480.0
LMBRD1	-1669	-4092.0
MCCC1	-7955	-6003.0
MCCC2	-6852	-4695.0
MMAA	-3750	-3991.0
MMAB	-7121	-6964.5
MMACHC	-4312	-2830.5
MMADHC	-7917	-8068.0
MTR	-8115	-7974.0
MTRR	-666	-627.5
PC	-4126	-5730.0
PCCB	-2116	-2355.0

---

---

Chaperone Mediated Autophagy

Chaperone Mediated Autophagy

metric	value
setSize	12
pMANOVA	0.15
p.adjustMANOVA	0.505
s.dist	0.415
s.wholegene	-0.263
s.promoter	-0.321
p.wholegene	0.115
p.promoter	0.0544

Top 20 genes

Gene	wholegene	promoter
UBC	-8828	-8547.0
RPS27A	-7906	-8712.5
ARL13B	-7909	-7442.0
UBB	-7572	-7240.0
EEF1A1	-6839	-6367.0
PARK7	-5477	-7246.0
HSP90AB1	-6106	-6165.0
HSP90AA1	-4087	-6691.0
PLIN3	-2427	-4399.0
PCNT	-2092	-2266.0
PLIN2	-1559	-1586.0
UBA52	-2489	-634.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ARL13B	-7909	-7442.0
EEF1A1	-6839	-6367.0
HSP90AA1	-4087	-6691.0
HSP90AB1	-6106	-6165.0
PARK7	-5477	-7246.0
PCNT	-2092	-2266.0
PLIN2	-1559	-1586.0
PLIN3	-2427	-4399.0
RPS27A	-7906	-8712.5
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0

---

---

Ion homeostasis

Ion homeostasis

metric	value
setSize	25
pMANOVA	0.00466
p.adjustMANOVA	0.112
s.dist	0.414
s.wholegene	0.367
s.promoter	0.193
p.wholegene	0.00151
p.promoter	0.0952

Top 20 genes

Gene	wholegene	promoter
DMPK	617	844.0
CAMK2G	489	0.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
AHCYL1	-3196	-3763.0
ASPH	-355	-3051.0
ATP1A1	-3041	-7091.0
ATP1A3	-855	-6010.0
ATP1B1	-4362	-1564.0
ATP1B3	-2728	-2241.0
ATP2A1	127	-612.0
ATP2A2	-1603	0.5
ATP2A3	-1188	-5328.0
ATP2B4	-2087	-1335.0
CALM1	-763	-817.0
CAMK2D	-4472	-6176.0
CAMK2G	489	0.5
DMPK	617	844.0
FXYD7	-1476	-659.0
ITPR1	-622	-4643.0
ITPR2	-8334	-8395.0
ITPR3	-4685	-7946.0
KCNJ11	-3910	-4765.0
ORAI1	-4515	-2655.0
ORAI2	-880	-480.0
PRKACA	-4168	-5464.0
SLC8A3	122	-327.0
SRI	-2464	-4645.0
TRPC1	-203	0.5

---

---

HDR through Homologous Recombination (HRR)

HDR through Homologous Recombination (HRR)

metric	value
setSize	55
pMANOVA	0.000239
p.adjustMANOVA	0.0466
s.dist	0.414
s.wholegene	-0.306
s.promoter	-0.28
p.wholegene	8.89e-05
p.promoter	0.000338

Top 20 genes

Gene	wholegene	promoter
ATM	-8863	-8945.5
BRCA1	-8881	-8797.5
ATR	-8756	-8697.0
UBC	-8828	-8547.0
MUS81	-8355	-8759.0
KAT5	-8805	-8198.0
RBBP8	-8371	-8270.0
BRCA2	-8179	-8433.0
RPS27A	-7906	-8712.5
RFC3	-8297	-8030.0
RAD51	-8094	-8226.0
RMI1	-8816	-7389.5
DNA2	-8799	-7266.0
GEN1	-7388	-8523.5
BLM	-8137	-7501.0
POLK	-7645	-7609.5
RFC5	-6582	-8619.0
TOP3A	-7966	-7020.5
UBB	-7572	-7240.0
POLD1	-7337	-7360.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ATM	-8863	-8945.5
ATR	-8756	-8697.0
ATRIP	-3341	-2471.0
BARD1	-4220	-363.0
BLM	-8137	-7501.0
BRCA1	-8881	-8797.5
BRCA2	-8179	-8433.0
BRIP1	420	349.0
CHEK1	399	-2304.0
DNA2	-8799	-7266.0
EME1	-3386	-2531.5
EME2	-8426	-2554.5
EXO1	-8207	-6078.0
GEN1	-7388	-8523.5
HUS1	-3666	-5490.0
KAT5	-8805	-8198.0
MUS81	-8355	-8759.0
NBN	-1031	-1658.0
PALB2	-394	-839.5
PCNA	-4533	-5027.0
POLD1	-7337	-7360.0
POLD2	-1513	-2017.0
POLD3	-6164	-6737.0
POLD4	-7326	-6917.0
POLE	-3211	-428.5
POLE2	-5401	-6509.0
POLE3	-3220	-6444.5
POLE4	-4593	-4380.0
POLH	-5229	-3833.5
POLK	-7645	-7609.5
RAD1	-7303	-6683.5
RAD17	-5641	-5393.5
RAD50	-2420	-1967.0
RAD51	-8094	-8226.0
RAD51AP1	-4995	-3956.5
RAD9A	-1036	-3132.0
RAD9B	-4455	-7770.5
RBBP8	-8371	-8270.0
RFC2	-7089	-5672.0
RFC3	-8297	-8030.0
RFC4	-62	-456.0
RFC5	-6582	-8619.0
RMI1	-8816	-7389.5
RPA1	99	-3377.5
RPA3	-4170	-6328.0
RPS27A	-7906	-8712.5
RTEL1	-5850	-4022.0
TOP3A	-7966	-7020.5
TOPBP1	-3780	-3108.0
UBA52	-2489	-634.0
UBB	-7572	-7240.0
UBC	-8828	-8547.0
WRN	-8468	-4029.5
XRCC2	-4263	-4285.0
XRCC3	-2802	-7805.5

---

---

HDMs demethylate histones

HDMs demethylate histones

metric	value
setSize	15
pMANOVA	0.0654
p.adjustMANOVA	0.379
s.dist	0.414
s.wholegene	-0.226
s.promoter	-0.347
p.wholegene	0.129
p.promoter	0.0199

Top 20 genes

Gene	wholegene	promoter
KDM6B	-8740	-8725.0
KDM2A	-7911	-8711.0
KDM4A	-7695	-8848.0
KDM5A	-8068	-7913.0
KDM2B	-8299	-7640.0
KDM3A	-7631	-7939.0
KDM1A	-7056	-7955.0
KDM4C	-5897	-7422.0
KDM1B	-4882	-7228.5
JMJD6	-4896	-4024.5
ARID5B	-2210	-3611.0
MINA	-1814	-2120.0
KDM4D	-1510	-2052.5
KDM3B	-225	-602.0

Click HERE to show all gene set members

All member genes

	wholegene	promoter
ARID5B	-2210	-3611.0
JMJD6	-4896	-4024.5
KDM1A	-7056	-7955.0
KDM1B	-4882	-7228.5
KDM2A	-7911	-8711.0
KDM2B	-8299	-7640.0
KDM3A	-7631	-7939.0
KDM3B	-225	-602.0
KDM4A	-7695	-8848.0
KDM4B	428	-1273.0
KDM4C	-5897	-7422.0
KDM4D	-1510	-2052.5
KDM5A	-8068	-7913.0
KDM6B	-8740	-8725.0
MINA	-1814	-2120.0

---

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

metric	value
setSize	15
pMANOVA	0.0464
p.adjustMANOVA	0.338
s.dist	0.414
s.wholegene	-0.202
s.promoter	-0.362
p.wholegene	0.177
p.promoter	0.0153

Top 20 genes

Gene	wholegene	promoter
CLP1	-8837	-8773.0
NUDT21	-7926	-8451.5
SYMPK	-8720	-7355.0
CPSF2	-7360	-7963.5
CSTF1	-7001	-8202.5
NCBP1	-8220	-6163.5
PAPOLA	-3284	-7720.0
FIP1L1	-3809	-5106.0
CPSF3	-2928	-5893.5
PABPN1	-2924	-4971.0
CPSF1	-1021	-7599.0
WDR33	-2028	-3644.0
NCBP2	-6856	-1030.5
CPSF4	-1248	-4246.5

Click HERE to show all gene set members

All member genes

	wholegene	promoter
CLP1	-8837	-8773.0
CPSF1	-1021	-7599.0
CPSF2	-7360	-7963.5
CPSF3	-2928	-5893.5
CPSF4	-1248	-4246.5
CPSF6	-2432	0.5
CSTF1	-7001	-8202.5
FIP1L1	-3809	-5106.0
NCBP1	-8220	-6163.5
NCBP2	-6856	-1030.5
NUDT21	-7926	-8451.5
PABPN1	-2924	-4971.0
PAPOLA	-3284	-7720.0
SYMPK	-8720	-7355.0
WDR33	-2028	-3644.0

---

---

Rap1 signalling

Rap1 signalling

metric	value
setSize	11
pMANOVA	0.176
p.adjustMANOVA	0.516
s.dist	0.412
s.wholegene	-0.322
s.promoter	-0.257
p.wholegene	0.0644
p.promoter	0.14

Top 20 genes

Gene	wholegene	promoter
YWHAB	-7364	-8384
RAP1B	-7703	-7710
RAP1GAP2	-5572	-8585
PRKACB	-7096	-6437
RAP1A	-6069	-4639
YWHAZ	-6394	-4374
PRKACA	-4168	-5464
RAF1	-6513	-2826
RASGRP1	-2968	-5315
SIPA1	-4574	-2410
RASGRP2	-2799	-2083

Click HERE to show all gene set members

All member genes

	wholegene	promoter
PRKACA	-4168	-5464
PRKACB	-7096	-6437
RAF1	-6513	-2826
RAP1A	-6069	-4639
RAP1B	-7703	-7710
RAP1GAP2	-5572	-8585
RASGRP1	-2968	-5315
RASGRP2	-2799	-2083
SIPA1	-4574	-2410
YWHAB	-7364	-8384
YWHAZ	-6394	-4374

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.2.4    GGally_2.1.2     ggplot2_3.3.6    reshape2_1.4.4  
##  [5] beeswarm_0.4.0   gplots_3.1.3     gtools_3.9.2     tibble_3.1.7    
##  [9] echarts4r_0.4.3  mitch_1.4.1      eulerr_6.1.1     kableExtra_1.3.4
## [13] dplyr_1.0.9     
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.8.3       svglite_2.1.0      rprojroot_2.0.3    assertthat_0.2.1  
##  [5] digest_0.6.29      utf8_1.2.2         mime_0.12          R6_2.5.1          
##  [9] plyr_1.8.7         evaluate_0.15      httr_1.4.3         highr_0.9         
## [13] pillar_1.7.0       rlang_1.0.2        rstudioapi_0.13    jquerylib_0.1.4   
## [17] rmarkdown_2.14     labeling_0.4.2     desc_1.4.1         webshot_0.5.3     
## [21] stringr_1.4.0      htmlwidgets_1.5.4  munsell_0.5.0      shiny_1.7.1       
## [25] compiler_4.2.0     httpuv_1.6.5       xfun_0.30          pkgconfig_2.0.3   
## [29] systemfonts_1.0.4  htmltools_0.5.2    tidyselect_1.1.2   gridExtra_2.3     
## [33] reshape_0.8.9      fansi_1.0.3        viridisLite_0.4.0  withr_2.5.0       
## [37] crayon_1.5.1       later_1.3.0        brio_1.1.3         bitops_1.0-7      
## [41] MASS_7.3-57        grid_4.2.0         jsonlite_1.8.0     xtable_1.8-4      
## [45] gtable_0.3.0       lifecycle_1.0.1    DBI_1.1.2          magrittr_2.0.3    
## [49] scales_1.2.0       KernSmooth_2.23-20 cli_3.3.0          stringi_1.7.6     
## [53] farver_2.1.0       promises_1.2.0.1   testthat_3.1.4     xml2_1.3.3        
## [57] bslib_0.3.1        ellipsis_0.3.2     generics_0.1.2     vctrs_0.4.1       
## [61] RColorBrewer_1.1-3 tools_4.2.0        glue_1.6.2         purrr_0.3.4       
## [65] fastmap_1.1.0      yaml_2.3.5         colorspace_2.0-3   caTools_1.18.2    
## [69] rvest_1.0.2        knitr_1.39         sass_0.4.1

END of report