date generated: 2026-06-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
score
AARS2 -7.2459291
AASS -0.2262333
ABAT -0.7818429
ABCB10 0.1846879
ABCB6 0.2339680
ABCB7 -0.3214584

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2734
num_genes_in_profile 982
duplicated_genes_present 0
num_profile_genes_in_sets 747
num_profile_genes_not_in_sets 235

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2734
num_genesets_excluded 2636
num_genesets_included 98

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Mitochondrial translation 93 2.14e-05 -0.2670 0.00260
Mitochondrial translation termination 87 4.31e-05 -0.2640 0.00260
Mitochondrial translation initiation 87 4.64e-05 -0.2630 0.00260
Mitochondrial translation elongation 87 7.01e-05 -0.2570 0.00295
Translation 113 2.11e-04 -0.2130 0.00709
Metabolism of proteins 234 6.76e-04 -0.1470 0.01890
tRNA processing in the mitochondrion 17 1.34e-03 0.4530 0.03210
Formation of ATP by chemiosmotic coupling 16 3.71e-03 -0.4220 0.07780
Cytokine Signaling in Immune system 14 4.60e-03 0.4400 0.08580
Signaling by Interleukins 11 9.44e-03 0.4540 0.14800
tRNA processing 29 1.08e-02 0.2770 0.14800
Immune System 35 1.11e-02 0.2520 0.14800
Class I peroxisomal membrane protein import 9 1.14e-02 0.4890 0.14800
rRNA processing 21 1.42e-02 0.3120 0.15900
rRNA processing in the mitochondrion 21 1.42e-02 0.3120 0.15900
Mitochondrial protein import 61 1.91e-02 -0.1790 0.20100
Mitochondrial biogenesis 44 2.15e-02 -0.2050 0.21200
DNA Repair 7 2.27e-02 0.4990 0.21200
Activation of gene expression by SREBF (SREBP) 5 2.76e-02 0.5700 0.23200
Regulation of cholesterol biosynthesis by SREBP (SREBF) 5 2.76e-02 0.5700 0.23200
Organelle biogenesis and maintenance 45 3.01e-02 -0.1910 0.24000
Base Excision Repair 5 5.46e-02 0.4980 0.39900
Resolution of Abasic Sites (AP sites) 5 5.46e-02 0.4980 0.39900
Integration of energy metabolism 5 6.24e-02 0.4820 0.42200
Transcriptional activation of mitochondrial biogenesis 16 6.28e-02 -0.2710 0.42200
Mitochondrial RNA degradation 22 7.20e-02 0.2240 0.44900
Glycine degradation 6 7.53e-02 -0.4210 0.44900
FASTK family proteins regulate processing and stability of mitochondrial RNAs 16 7.85e-02 0.2560 0.44900
Metabolism of RNA 45 8.23e-02 0.1530 0.44900
Innate Immune System 24 9.14e-02 0.2020 0.44900
Peroxisomal lipid metabolism 13 9.20e-02 0.2720 0.44900
Developmental Biology 5 9.30e-02 0.4350 0.44900
Deubiquitination 12 9.62e-02 0.2790 0.44900
Ubiquinol biosynthesis 12 9.67e-02 0.2790 0.44900
Peroxisomal protein import 19 9.87e-02 0.2210 0.44900
Metabolism of cofactors 13 9.89e-02 0.2660 0.44900
Mitochondrial Fatty Acid Beta-Oxidation 26 1.03e-01 -0.1870 0.44900
Cellular response to chemical stress 29 1.03e-01 0.1780 0.44900
Cristae formation 29 1.04e-01 -0.1770 0.44900
Neutrophil degranulation 15 1.09e-01 0.2410 0.45200
Respiratory electron transport 135 1.10e-01 0.0855 0.45200
Ub-specific processing proteases 11 1.26e-01 0.2680 0.50600
Detoxification of Reactive Oxygen Species 13 1.39e-01 0.2380 0.54200
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 5 1.48e-01 0.3740 0.54200
alpha-linolenic acid (ALA) metabolism 5 1.48e-01 0.3740 0.54200
KEAP1-NFE2L2 pathway 5 1.50e-01 0.3730 0.54200
Regulated Necrosis 5 1.52e-01 0.3720 0.54200
MAPK family signaling cascades 5 1.66e-01 -0.3580 0.56900
Cellular responses to stimuli 43 1.78e-01 0.1210 0.56900
Mitochondrial protein degradation 95 1.80e-01 -0.0836 0.56900


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Mitochondrial translation 93 2.14e-05 -0.26700 0.00260
Mitochondrial translation termination 87 4.31e-05 -0.26400 0.00260
Mitochondrial translation initiation 87 4.64e-05 -0.26300 0.00260
Mitochondrial translation elongation 87 7.01e-05 -0.25700 0.00295
Translation 113 2.11e-04 -0.21300 0.00709
Metabolism of proteins 234 6.76e-04 -0.14700 0.01890
tRNA processing in the mitochondrion 17 1.34e-03 0.45300 0.03210
Formation of ATP by chemiosmotic coupling 16 3.71e-03 -0.42200 0.07780
Cytokine Signaling in Immune system 14 4.60e-03 0.44000 0.08580
Signaling by Interleukins 11 9.44e-03 0.45400 0.14800
tRNA processing 29 1.08e-02 0.27700 0.14800
Immune System 35 1.11e-02 0.25200 0.14800
Class I peroxisomal membrane protein import 9 1.14e-02 0.48900 0.14800
rRNA processing 21 1.42e-02 0.31200 0.15900
rRNA processing in the mitochondrion 21 1.42e-02 0.31200 0.15900
Mitochondrial protein import 61 1.91e-02 -0.17900 0.20100
Mitochondrial biogenesis 44 2.15e-02 -0.20500 0.21200
DNA Repair 7 2.27e-02 0.49900 0.21200
Activation of gene expression by SREBF (SREBP) 5 2.76e-02 0.57000 0.23200
Regulation of cholesterol biosynthesis by SREBP (SREBF) 5 2.76e-02 0.57000 0.23200
Organelle biogenesis and maintenance 45 3.01e-02 -0.19100 0.24000
Base Excision Repair 5 5.46e-02 0.49800 0.39900
Resolution of Abasic Sites (AP sites) 5 5.46e-02 0.49800 0.39900
Integration of energy metabolism 5 6.24e-02 0.48200 0.42200
Transcriptional activation of mitochondrial biogenesis 16 6.28e-02 -0.27100 0.42200
Mitochondrial RNA degradation 22 7.20e-02 0.22400 0.44900
Glycine degradation 6 7.53e-02 -0.42100 0.44900
FASTK family proteins regulate processing and stability of mitochondrial RNAs 16 7.85e-02 0.25600 0.44900
Metabolism of RNA 45 8.23e-02 0.15300 0.44900
Innate Immune System 24 9.14e-02 0.20200 0.44900
Peroxisomal lipid metabolism 13 9.20e-02 0.27200 0.44900
Developmental Biology 5 9.30e-02 0.43500 0.44900
Deubiquitination 12 9.62e-02 0.27900 0.44900
Ubiquinol biosynthesis 12 9.67e-02 0.27900 0.44900
Peroxisomal protein import 19 9.87e-02 0.22100 0.44900
Metabolism of cofactors 13 9.89e-02 0.26600 0.44900
Mitochondrial Fatty Acid Beta-Oxidation 26 1.03e-01 -0.18700 0.44900
Cellular response to chemical stress 29 1.03e-01 0.17800 0.44900
Cristae formation 29 1.04e-01 -0.17700 0.44900
Neutrophil degranulation 15 1.09e-01 0.24100 0.45200
Respiratory electron transport 135 1.10e-01 0.08550 0.45200
Ub-specific processing proteases 11 1.26e-01 0.26800 0.50600
Detoxification of Reactive Oxygen Species 13 1.39e-01 0.23800 0.54200
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 5 1.48e-01 0.37400 0.54200
alpha-linolenic acid (ALA) metabolism 5 1.48e-01 0.37400 0.54200
KEAP1-NFE2L2 pathway 5 1.50e-01 0.37300 0.54200
Regulated Necrosis 5 1.52e-01 0.37200 0.54200
MAPK family signaling cascades 5 1.66e-01 -0.35800 0.56900
Cellular responses to stimuli 43 1.78e-01 0.12100 0.56900
Mitochondrial protein degradation 95 1.80e-01 -0.08360 0.56900
Propionyl-CoA catabolism 5 1.80e-01 -0.34700 0.56900
PDH complex synthesizes acetyl-CoA from PYR 5 1.83e-01 -0.34500 0.56900
Processing of SMDT1 15 1.86e-01 -0.19900 0.56900
Fatty acyl-CoA biosynthesis 7 1.88e-01 0.28900 0.56900
Miro GTPase Cycle 5 1.93e-01 0.33800 0.56900
Complex I biogenesis 62 2.01e-01 0.09680 0.56900
Post-translational protein modification 28 2.02e-01 0.14100 0.56900
Biotin transport and metabolism 6 2.06e-01 -0.29900 0.56900
Defective HLCS causes multiple carboxylase deficiency 6 2.06e-01 -0.29900 0.56900
Defects in biotin (Btn) metabolism 6 2.06e-01 -0.29900 0.56900
Metabolism of water-soluble vitamins and cofactors 34 2.09e-01 -0.12700 0.56900
Cellular responses to stress 42 2.10e-01 0.11400 0.56900
Beta-oxidation of very long chain fatty acids 6 2.30e-01 0.28400 0.59500
Aerobic respiration and respiratory electron transport 200 2.34e-01 0.05450 0.59500
Lysine catabolism 7 2.35e-01 -0.26000 0.59500
Generic Transcription Pathway 37 2.39e-01 0.11400 0.59500
RNA Polymerase II Transcription 37 2.39e-01 0.11400 0.59500
Transport of inorganic cations/anions and amino acids/oligopeptides 6 2.44e-01 -0.27600 0.59500
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 19 2.44e-01 0.15600 0.59500
Mitochondrial iron-sulfur cluster biogenesis 13 2.64e-01 -0.18000 0.63300
Factors involved in megakaryocyte development and platelet production 6 2.80e-01 0.25600 0.66200
Transcriptional Regulation by TP53 31 2.84e-01 0.11300 0.66300
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 2.91e-01 -0.27400 0.66900
mitochondrial fatty acid beta-oxidation of saturated fatty acids 8 2.96e-01 -0.21500 0.67100
Metabolism of steroids 14 3.00e-01 0.16100 0.67300
Metabolism 422 3.05e-01 0.03820 0.67400
Neurotransmitter release cycle 5 3.35e-01 -0.25000 0.71900
Membrane Trafficking 5 3.38e-01 0.24800 0.71900
Vesicle-mediated transport 5 3.38e-01 0.24800 0.71900
Beta-oxidation of pristanoyl-CoA 5 3.54e-01 0.24000 0.73700
Pyruvate metabolism 22 3.55e-01 0.11500 0.73700
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 5 3.72e-01 0.23100 0.75200
Intrinsic Pathway for Apoptosis 12 3.73e-01 0.15000 0.75200
Defects in vitamin and cofactor metabolism 10 3.76e-01 -0.16300 0.75200
Mitochondrial calcium ion transport 20 3.80e-01 -0.11500 0.75200
tRNA modification in the mitochondrion 9 3.92e-01 0.16600 0.76600
Neuronal System 8 4.02e-01 -0.17200 0.76700
Transmission across Chemical Synapses 8 4.02e-01 -0.17200 0.76700
Signal Transduction 48 4.33e-01 0.06700 0.80900
Synthesis of PA 8 4.37e-01 0.15900 0.80900
Complex IV assembly 38 4.43e-01 0.07340 0.80900
Mitochondrial unfolded protein response (UPRmt) 8 4.43e-01 0.15700 0.80900
Biological oxidations 21 4.66e-01 0.09290 0.83400
Signaling by Receptor Tyrosine Kinases 5 4.67e-01 0.18900 0.83400
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 4.80e-01 -0.16700 0.84800
Disease 56 4.94e-01 0.05440 0.86500
Gene expression (Transcription) 46 5.12e-01 0.05730 0.88600
Metabolism of folate and pterines 7 5.22e-01 -0.14100 0.89400
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 5.30e-01 -0.16300 0.89900
Infectious disease 14 5.41e-01 0.09520 0.89900
Citric acid cycle (TCA cycle) 34 5.68e-01 -0.05760 0.89900
RHO GTPase cycle 14 5.69e-01 0.08870 0.89900
Signaling by Rho GTPases 14 5.69e-01 0.08870 0.89900
Complex III assembly 22 5.69e-01 0.07090 0.89900
Autophagy 16 5.80e-01 0.08060 0.89900
Macroautophagy 16 5.80e-01 0.08060 0.89900
Selective autophagy 16 5.80e-01 0.08060 0.89900
Synthesis of Ketone Bodies 5 5.82e-01 0.14300 0.89900
Glycerophospholipid biosynthesis 17 5.95e-01 0.07530 0.89900
Phospholipid metabolism 17 5.95e-01 0.07530 0.89900
Maturation of TCA enzymes and regulation of TCA cycle 20 5.96e-01 -0.06920 0.89900
Cytoprotection by HMOX1 14 6.03e-01 0.08090 0.89900
Strand-asynchronous mitochondrial DNA replication 10 6.05e-01 -0.09510 0.89900
TP53 Regulates Metabolic Genes 21 6.19e-01 0.06350 0.90800
SARS-CoV Infections 6 6.22e-01 -0.11700 0.90800
Regulation of pyruvate metabolism 13 6.27e-01 -0.07840 0.90900
Malate-aspartate shuttle 6 6.53e-01 0.10700 0.91300
Signaling by Nuclear Receptors 14 6.54e-01 0.06970 0.91300
Apoptosis 15 6.55e-01 0.06720 0.91300
Programmed Cell Death 15 6.55e-01 0.06720 0.91300
Signaling by Retinoic Acid 11 6.61e-01 -0.07690 0.91300
Mitochondrial tRNA aminoacylation 20 6.68e-01 0.05590 0.91300
tRNA Aminoacylation 20 6.68e-01 0.05590 0.91300
Diseases of signal transduction by growth factor receptors and second messengers 6 6.79e-01 -0.09800 0.91300
SLC-mediated transmembrane transport 10 6.88e-01 -0.07370 0.91300
Phase II - Conjugation of compounds 7 6.92e-01 0.08690 0.91300
Metabolism of carbohydrates 5 6.95e-01 -0.10200 0.91300
Regulation of pyruvate dehydrogenase (PDH) complex 12 7.00e-01 -0.06480 0.91300
Protein lipoylation 9 7.01e-01 -0.07430 0.91300
Branched-chain ketoacid dehydrogenase kinase deficiency 5 7.12e-01 0.09560 0.91900
Vitamin B5 (pantothenate) metabolism 7 7.18e-01 -0.07930 0.91900
Phase I - Functionalization of compounds 13 7.24e-01 0.05690 0.91900
Interconversion of nucleotide di- and triphosphates 9 7.27e-01 0.06750 0.91900
Protein localization 89 7.36e-01 -0.02170 0.92200
Transport of small molecules 40 7.48e-01 -0.03000 0.93000
Hemostasis 10 7.70e-01 0.05370 0.94500
tRNA modification in the nucleus and cytosol 8 7.77e-01 -0.05800 0.94500
Viral Infection Pathways 11 7.81e-01 0.04880 0.94500
Branched-chain amino acid catabolism 19 7.82e-01 -0.03710 0.94500
RHOG GTPase cycle 5 7.88e-01 -0.06980 0.94500
rRNA modification in the mitochondrion 6 7.95e-01 0.06150 0.94700
Degradation of cysteine and homocysteine 7 8.08e-01 0.05320 0.94700
Sulfur amino acid metabolism 7 8.08e-01 0.05320 0.94700
DNA Replication 11 8.16e-01 -0.04070 0.94700
Glyoxylate metabolism and glycine degradation 11 8.29e-01 -0.03790 0.94700
Mitophagy 13 8.30e-01 -0.03470 0.94700
Metabolism of lipids 88 8.40e-01 0.01300 0.94700
Signaling by GPCR 5 8.48e-01 -0.04970 0.94700
Glutamate and glutamine metabolism 8 8.50e-01 0.03880 0.94700
Metabolic disorders of biological oxidation enzymes 5 8.52e-01 0.04850 0.94700
Heme biosynthesis 6 8.57e-01 -0.04270 0.94700
Metabolism of porphyrins 6 8.57e-01 -0.04270 0.94700
PINK1-PRKN Mediated Mitophagy 11 8.87e-01 -0.02480 0.96200
Diseases of metabolism 27 8.89e-01 -0.01580 0.96200
PPARA activates gene expression 7 8.93e-01 0.02950 0.96200
Regulation of lipid metabolism by PPARalpha 7 8.93e-01 0.02950 0.96200
Metabolism of amino acids and derivatives 69 9.08e-01 0.00837 0.96800
TP53 Regulates Transcription of Cell Death Genes 7 9.20e-01 0.02210 0.96800
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 7 9.20e-01 0.02210 0.96800
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 5 9.23e-01 -0.02520 0.96800
Fatty acid metabolism 52 9.27e-01 0.00753 0.96800
Adaptive Immune System 5 9.46e-01 0.01740 0.97900
ABC-family proteins mediated transport 6 9.53e-01 -0.01400 0.97900
Metabolism of vitamins and cofactors 48 9.56e-01 -0.00477 0.97900
Ketone body metabolism 6 9.74e-01 0.00786 0.98800
Apoptotic factor-mediated response 6 9.76e-01 0.00717 0.98800
Diseases of branched-chain amino acid catabolism 12 9.89e-01 0.00241 0.99200
Metabolism of nucleotides 15 9.92e-01 -0.00159 0.99200


Detailed Gene set reports



Mitochondrial translation
set Mitochondrial translation
setSize 93
pANOVA 2.14e-05
s.dist -0.267
p.adjustANOVA 0.0026


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
TUFM -425
MRPL52 -420
MRPL49 -418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
TUFM -425
MRPL52 -420
MRPL49 -418
MRPL23 -415
MRPL12 -408
MRPL19 -404
MRPL50 -401
MRPL11 -399
MRPL47 -395
MRPL34 -378
MTIF3 -371
MRPL48 -370
MRPL16 -364
MRPL4 -347
MRPL40 -344
MRPL2 -337
MRPL28 -331
MRPL3 -325
MRPL14 -320
MRPL57 -319
MRPL9 -318
MRPL24 -309
MRPL46 -308
MRPS30 -304
MRPL27 -302
MRPL58 -291
MRPL21 -283
MTFMT -282
MRPL38 -281
MRPS34 -260
MRPL51 -257
MRRF -247
MRPL55 -246
MRPL15 -225
GADD45GIP1 -208
MRPS18A -202
MRPL22 -199
MRPL39 -194
TSFM -191
MRPL37 -175
MRPL53 -167
MRPL13 -157
MRPL1 -133
DAP3 -126
MRPL17 -57
MRPS7 20
ERAL1 43
MRPS14 62
MRPS5 68
PTCD3 77
MRPS33 78
MTIF2 99
MRPS15 104
MTRF1L 148
MRPS21 191
MRPS23 199
MRPS9 235
MRPS31 236
MRPS25 261
MRPS35 268
MRPS2 279
GFM1 305
MRPS36 316
MRPS18B 317
CHCHD1 323
MRPS18C 325
MRPS10 365
OXA1L 368
MRPL36 373
MRPS26 380
MRPS11 388
MRPL45 424
MRPS28 429
MRPL35 435
MRPL20 452
MRPL43 457


Mitochondrial translation termination
set Mitochondrial translation termination
setSize 87
pANOVA 4.31e-05
s.dist -0.264
p.adjustANOVA 0.0026


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
MRPL52 -420
MRPL49 -418
MRPL23 -415

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
MRPL52 -420
MRPL49 -418
MRPL23 -415
MRPL12 -408
MRPL19 -404
MRPL50 -401
MRPL11 -399
MRPL47 -395
MRPL34 -378
MRPL48 -370
MRPL16 -364
MRPL4 -347
MRPL40 -344
MRPL2 -337
MRPL28 -331
MRPL3 -325
MRPL14 -320
MRPL57 -319
MRPL9 -318
MRPL24 -309
MRPL46 -308
MRPS30 -304
MRPL27 -302
MRPL58 -291
MRPL21 -283
MRPL38 -281
MRPS34 -260
MRPL51 -257
MRRF -247
MRPL55 -246
MRPL15 -225
GADD45GIP1 -208
MRPS18A -202
MRPL22 -199
MRPL39 -194
MRPL37 -175
MRPL53 -167
MRPL13 -157
MRPL1 -133
DAP3 -126
MRPL17 -57
MRPS7 20
ERAL1 43
MRPS14 62
MRPS5 68
PTCD3 77
MRPS33 78
MRPS15 104
MTRF1L 148
MRPS21 191
MRPS23 199
MRPS9 235
MRPS31 236
MRPS25 261
MRPS35 268
MRPS2 279
MRPS36 316
MRPS18B 317
CHCHD1 323
MRPS18C 325
MRPS10 365
OXA1L 368
MRPL36 373
MRPS26 380
MRPS11 388
MRPL45 424
MRPS28 429
MRPL35 435
MRPL20 452
MRPL43 457


Mitochondrial translation initiation
set Mitochondrial translation initiation
setSize 87
pANOVA 4.64e-05
s.dist -0.263
p.adjustANOVA 0.0026


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
MRPL52 -420
MRPL49 -418
MRPL23 -415
MRPL12 -408

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
MRPL52 -420
MRPL49 -418
MRPL23 -415
MRPL12 -408
MRPL19 -404
MRPL50 -401
MRPL11 -399
MRPL47 -395
MRPL34 -378
MTIF3 -371
MRPL48 -370
MRPL16 -364
MRPL4 -347
MRPL40 -344
MRPL2 -337
MRPL28 -331
MRPL3 -325
MRPL14 -320
MRPL57 -319
MRPL9 -318
MRPL24 -309
MRPL46 -308
MRPS30 -304
MRPL27 -302
MRPL58 -291
MRPL21 -283
MTFMT -282
MRPL38 -281
MRPS34 -260
MRPL51 -257
MRPL55 -246
MRPL15 -225
GADD45GIP1 -208
MRPS18A -202
MRPL22 -199
MRPL39 -194
MRPL37 -175
MRPL53 -167
MRPL13 -157
MRPL1 -133
DAP3 -126
MRPL17 -57
MRPS7 20
ERAL1 43
MRPS14 62
MRPS5 68
PTCD3 77
MRPS33 78
MTIF2 99
MRPS15 104
MRPS21 191
MRPS23 199
MRPS9 235
MRPS31 236
MRPS25 261
MRPS35 268
MRPS2 279
MRPS36 316
MRPS18B 317
CHCHD1 323
MRPS18C 325
MRPS10 365
OXA1L 368
MRPL36 373
MRPS26 380
MRPS11 388
MRPL45 424
MRPS28 429
MRPL35 435
MRPL20 452
MRPL43 457


Mitochondrial translation elongation
set Mitochondrial translation elongation
setSize 87
pANOVA 7.01e-05
s.dist -0.257
p.adjustANOVA 0.00295


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
TUFM -425
MRPL52 -420
MRPL49 -418
MRPL23 -415

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
TUFM -425
MRPL52 -420
MRPL49 -418
MRPL23 -415
MRPL12 -408
MRPL19 -404
MRPL50 -401
MRPL11 -399
MRPL47 -395
MRPL34 -378
MRPL48 -370
MRPL16 -364
MRPL4 -347
MRPL40 -344
MRPL2 -337
MRPL28 -331
MRPL3 -325
MRPL14 -320
MRPL57 -319
MRPL9 -318
MRPL24 -309
MRPL46 -308
MRPS30 -304
MRPL27 -302
MRPL58 -291
MRPL21 -283
MRPL38 -281
MRPS34 -260
MRPL51 -257
MRPL55 -246
MRPL15 -225
GADD45GIP1 -208
MRPS18A -202
MRPL22 -199
MRPL39 -194
TSFM -191
MRPL37 -175
MRPL53 -167
MRPL13 -157
MRPL1 -133
DAP3 -126
MRPL17 -57
MRPS7 20
ERAL1 43
MRPS14 62
MRPS5 68
PTCD3 77
MRPS33 78
MRPS15 104
MRPS21 191
MRPS23 199
MRPS9 235
MRPS31 236
MRPS25 261
MRPS35 268
MRPS2 279
GFM1 305
MRPS36 316
MRPS18B 317
CHCHD1 323
MRPS18C 325
MRPS10 365
OXA1L 368
MRPL36 373
MRPS26 380
MRPS11 388
MRPL45 424
MRPS28 429
MRPL35 435
MRPL20 452
MRPL43 457


Translation
set Translation
setSize 113
pANOVA 0.000211
s.dist -0.213
p.adjustANOVA 0.00709


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
AARS2 -501
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
TUFM -425
MRPL52 -420

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
AARS2 -501
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
MRPL44 -438
AURKAIP1 -437
MRPS24 -435
MRPL33 -430
MRPS6 -426
TUFM -425
MRPL52 -420
MRPL49 -418
MRPL23 -415
MRPL12 -408
MRPL19 -404
MRPL50 -401
MRPL11 -399
MRPL47 -395
HARS2 -390
MRPL34 -378
MTIF3 -371
MRPL48 -370
MRPL16 -364
MRPL4 -347
MRPL40 -344
MRPL2 -337
MRPL28 -331
MRPL3 -325
MRPL14 -320
MRPL57 -319
MRPL9 -318
MRPL24 -309
MRPL46 -308
MRPS30 -304
MRPL27 -302
MRPL58 -291
MRPL21 -283
MTFMT -282
MRPL38 -281
VARS2 -265
MRPS34 -260
MRPL51 -257
MRRF -247
MRPL55 -246
MRPL15 -225
GADD45GIP1 -208
MRPS18A -202
MRPL22 -199
MRPL39 -194
TSFM -191
MRPL37 -175
MRPL53 -167
PPA2 -163
MRPL13 -157
YARS2 -136
MRPL1 -133
DAP3 -126
KARS1 -104
FARS2 -66
LARS2 -64
EARS2 -59
MRPL17 -57
PARS2 -38
MARS2 -29
SARS2 -26
MRPS7 20
ERAL1 43
CARS2 52
MRPS14 62
MRPS5 68
PTCD3 77
MRPS33 78
TARS2 89
MTIF2 99
MRPS15 104
MTRF1L 148
GARS1 159
MRPS21 191
DARS2 196
MRPS23 199
MRPS9 235
MRPS31 236
MRPS25 261
MRPS35 268
IARS2 269
MRPS2 279
RARS2 295
GFM1 305
MRPS36 316
MRPS18B 317
CHCHD1 323
MRPS18C 325
MRPS10 365
OXA1L 368
MRPL36 373
MRPS26 380
MRPS11 388
NARS2 403
MRPL45 424
MRPS28 429
MRPL35 435
WARS2 446
MRPL20 452
MRPL43 457


Metabolism of proteins
set Metabolism of proteins
setSize 234
pANOVA 0.000676
s.dist -0.147
p.adjustANOVA 0.0189


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRPS16 -511
MRPL10 -509
MRPS27 -505
TRIAP1 -503
AARS2 -501
GFM2 -498
MRPL30 -492
MRPL32 -490
MRPL54 -488
NDUFA2 -486
HADH -485
ACAD8 -482
MRPL41 -479
MRPS17 -476
MRPL42 -474
MRPS22 -465
MRPL18 -463
COX5B -459
NDUFB6 -450
DLST -443

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS16 -511.0
MRPL10 -509.0
MRPS27 -505.0
TRIAP1 -503.0
AARS2 -501.0
GFM2 -498.0
MRPL30 -492.0
MRPL32 -490.0
MRPL54 -488.0
NDUFA2 -486.0
HADH -485.0
ACAD8 -482.0
MRPL41 -479.0
MRPS17 -476.0
MRPL42 -474.0
MRPS22 -465.0
MRPL18 -463.0
COX5B -459.0
NDUFB6 -450.0
DLST -443.0
VDAC2 -439.0
MRPL44 -438.0
AURKAIP1 -437.0
MRPS24 -435.0
MRPL33 -430.0
MRPS6 -426.0
TUFM -425.0
ARL2 -421.0
MRPL52 -420.0
MRPL49 -418.0
MRPL23 -415.0
ATP5PF -410.0
MDH2 -409.0
MRPL12 -408.0
GLUD1 -407.0
MRPL19 -404.0
MRPL50 -401.0
MRPL11 -399.0
ATP5PD -398.0
MRPL47 -395.0
ECI1 -392.0
HARS2 -390.0
ECH1 -388.0
CHCHD2 -385.0
OGDH -379.0
MRPL34 -378.0
TIMM10 -377.0
TIMM9 -372.0
MTIF3 -371.0
MRPL48 -370.0
ATP5PO -368.0
SSBP1 -367.0
MRPL16 -364.0
NDUFAB1 -354.0
OXCT1 -349.0
MRPL4 -347.0
MRPL40 -344.0
PDHA1 -343.0
NDUFA13 -342.0
TIMM22 -340.0
MRPL2 -337.0
ATP5F1B -335.0
MRPL28 -331.0
MRPL3 -325.0
ATP5MG -323.0
MRPL14 -320.0
MRPL57 -319.0
MRPL9 -318.0
ALAS1 -317.0
HSPD1 -315.0
OMA1 -311.0
PDHB -310.0
MRPL24 -309.0
MRPL46 -308.0
MRPS30 -304.0
MRPL27 -302.0
TFAM -299.0
MRPL58 -291.0
SHMT2 -290.0
AFG3L2 -287.0
CLPP -286.0
MRPL21 -283.0
MTFMT -282.0
MRPL38 -281.0
ATP5F1A -275.0
OPA1 -269.0
VARS2 -265.0
NDUFV1 -262.0
MRPS34 -260.0
MRPL51 -257.0
MRRF -247.0
MRPL55 -246.0
PCCB -244.0
PGS1 -240.0
COX5A -239.0
MICU2 -230.0
GCSH -227.0
MRPL15 -225.0
PMPCA -222.0
GADD45GIP1 -208.0
ACOT2 -204.0
MRPS18A -202.0
ATP5F1C -200.0
MRPL22 -199.0
MRPL39 -194.0
TSFM -191.0
DLD -185.0
MRPL37 -175.0
ALDH2 -170.0
FDX1 -169.0
MRPL53 -167.0
PPA2 -163.0
NADK2 -161.0
SMDT1 -159.0
MRPL13 -157.0
BDH1 -156.0
PDK1 -155.0
LIPT1 -154.0
CS -153.0
YARS2 -136.0
MRPL1 -133.0
DAP3 -126.0
DLAT -107.0
KARS1 -104.0
VDAC3 -103.0
MSRB2 -90.0
ME2 -75.0
LONP1 -68.0
FARS2 -66.0
LARS2 -64.0
SUCLG2 -60.0
EARS2 -59.0
MRPL17 -57.0
OXSM -51.0
ACADSB -47.0
ACO2 -44.0
ARG2 -43.0
PARS2 -38.0
ALDH1B1 -32.0
MARS2 -29.0
SARS2 -26.0
ACAT1 -25.0
MSRA -4.0
TOMM70 10.0
MRPS7 20.0
FBXL4 29.0
RAB24 30.0
TWNK 33.0
ERAL1 43.0
PTRH2 45.0
TOMM20 48.0
CARS2 52.0
MRPS14 62.0
MRPS5 68.0
FKBP8 71.5
PTCD3 77.0
MRPS33 78.0
ETFB 82.0
TARS2 89.0
HSD17B10 97.0
MTIF2 99.0
MRPS15 104.0
CLPX 111.0
PARK7 115.0
MT-CO2 116.0
MTRF1L 148.0
STARD7 153.0
GARS1 159.0
STX17 160.0
SLC25A6 161.0
MSRB3 167.0
MAVS 171.0
PRKACA 172.0
MUL1 187.0
MRPS21 191.0
DARS2 196.0
MRPS23 199.0
NDUFS1 230.0
MRPS9 235.0
MRPS31 236.0
LIAS 241.0
IDH3A 244.0
UQCRC2 246.0
ARF5 248.0
VDAC1 250.0
IDE 254.0
HMGCS2 255.0
MT-ND5 260.0
MRPS25 261.0
TIMM17A 263.0
MRPS35 268.0
IARS2 269.0
SPG7 276.0
MRPS2 279.0
RARS2 295.0
GFM1 305.0
MRPS36 316.0
MRPS18B 317.0
DBT 318.0
CHCHD1 323.0
MRPS18C 325.0
MT-CO1 328.0
NDUFV3 337.0
SLC25A5 345.0
FH 351.0
NDUFS3 354.0
NFU1 358.0
MT-ND6 359.0
MRPS10 365.0
YME1L1 366.0
OXA1L 368.0
COX4I1 369.0
MRPL36 373.0
MT-ND2 375.0
MRPS26 380.0
MRPS11 388.0
NARS2 403.0
RHOT1 404.0
FECH 406.0
PRELID1 408.0
MT-ND1 412.0
HSPA9 413.0
IDH2 417.0
UQCRQ 421.0
MRPL45 424.0
MRPS28 429.0
MT-ATP6 432.0
ALDH18A1 433.0
MRPL35 435.0
USP30 444.0
WARS2 446.0
MRPL20 452.0
MRPL43 457.0
HTRA2 463.0


tRNA processing in the mitochondrion
set tRNA processing in the mitochondrion
setSize 17
pANOVA 0.00134
s.dist 0.453
p.adjustANOVA 0.0321


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
MT-ND1 412.0
MT-ND2 375.0
MT-ND6 359.0
TRNT1 335.0
MT-CO3 333.0
MT-CO1 328.0
MT-ND5 260.0
MT-CYB 202.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
PRORP -91.0
MT-ND3 -477.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
MT-ND1 412.0
MT-ND2 375.0
MT-ND6 359.0
TRNT1 335.0
MT-CO3 333.0
MT-CO1 328.0
MT-ND5 260.0
MT-CYB 202.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
PRORP -91.0
MT-ND3 -477.0


Formation of ATP by chemiosmotic coupling
set Formation of ATP by chemiosmotic coupling
setSize 16
pANOVA 0.00371
s.dist -0.422
p.adjustANOVA 0.0778


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5ME -462
ATP5PB -451
ATP5PF -410
ATP5PD -398
ATP5PO -368
ATP5F1B -335
ATP5MG -323
ATP5MF -322
ATP5F1E -293
ATP5F1A -275
DMAC2L -261
ATP5MC1 -231
ATP5F1C -200
ATP5F1D -171
MT-ATP8 431
MT-ATP6 432

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5ME -462
ATP5PB -451
ATP5PF -410
ATP5PD -398
ATP5PO -368
ATP5F1B -335
ATP5MG -323
ATP5MF -322
ATP5F1E -293
ATP5F1A -275
DMAC2L -261
ATP5MC1 -231
ATP5F1C -200
ATP5F1D -171
MT-ATP8 431
MT-ATP6 432


Cytokine Signaling in Immune system
set Cytokine Signaling in Immune system
setSize 14
pANOVA 0.0046
s.dist 0.44
p.adjustANOVA 0.0858


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA9 413
MAOA 372
BCL2 307
DUS2 298
CASP8 262
SOD2 247
CASP3 226
SOD1 207
PRKACA 172
MAVS 171
MCL1 139
BCL2L1 114
PDE12 17
NLRX1 -292

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA9 413
MAOA 372
BCL2 307
DUS2 298
CASP8 262
SOD2 247
CASP3 226
SOD1 207
PRKACA 172
MAVS 171
MCL1 139
BCL2L1 114
PDE12 17
NLRX1 -292


Signaling by Interleukins
set Signaling by Interleukins
setSize 11
pANOVA 0.00944
s.dist 0.454
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA9 413
MAOA 372
BCL2 307
CASP8 262
SOD2 247
CASP3 226
SOD1 207
PRKACA 172
MCL1 139
BCL2L1 114
NLRX1 -292

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA9 413
MAOA 372
BCL2 307
CASP8 262
SOD2 247
CASP3 226
SOD1 207
PRKACA 172
MCL1 139
BCL2L1 114
NLRX1 -292


tRNA processing
set tRNA processing
setSize 29
pANOVA 0.0108
s.dist 0.277
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
TRIT1 427.0
MT-ND1 412.0
MT-ND2 375.0
MT-ND6 359.0
TRMT61B 348.0
TRNT1 335.0
MT-CO3 333.0
MT-CO1 328.0
DUS2 298.0
MT-ND5 260.0
NSUN2 223.0
MT-CYB 202.0
TRMU 145.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
TRIT1 427.0
MT-ND1 412.0
MT-ND2 375.0
MT-ND6 359.0
TRMT61B 348.0
TRNT1 335.0
MT-CO3 333.0
MT-CO1 328.0
DUS2 298.0
MT-ND5 260.0
NSUN2 223.0
MT-CYB 202.0
TRMU 145.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
MTO1 15.0
QTRT1 -83.0
PRORP -91.0
TRMT1 -173.0
PUS1 -206.0
GTPBP3 -258.0
THG1L -387.0
MT-ND3 -477.0
TRMT5 -513.0


Immune System
set Immune System
setSize 35
pANOVA 0.0111
s.dist 0.252
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFC2 454
HSPA9 413
MAOA 372
FTH1 340
BCL2 307
DUS2 298
CASP8 262
SOD2 247
ACAA1 234
CASP3 226
ACLY 211
SOD1 207
CAT 200
PRKACA 172
MAVS 171
NIT2 156
MCL1 139
PRDX6 138
BCL2L1 114
ATAD3B 93

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFC2 454
HSPA9 413
MAOA 372
FTH1 340
BCL2 307
DUS2 298
CASP8 262
SOD2 247
ACAA1 234
CASP3 226
ACLY 211
SOD1 207
CAT 200
PRKACA 172
MAVS 171
NIT2 156
MCL1 139
PRDX6 138
BCL2L1 114
ATAD3B 93
PRDX4 80
THEM4 74
SNAP29 73
AHCYL1 66
STOM 49
RAB24 30
FBXL4 29
PDE12 17
TOMM70 10
CYB5R3 9
PTGES2 -255
NLRX1 -292
OSBPL1A -416
MGST1 -417
ECSIT -452


Class I peroxisomal membrane protein import
set Class I peroxisomal membrane protein import
setSize 9
pANOVA 0.0114
s.dist 0.489
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
GDAP1 466
FIS1 430
PEX11B 256
PXMP4 213
PXMP2 166
ALDH3A2 164
ABCD1 141
ABCD3 88
ATAD1 5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GDAP1 466
FIS1 430
PEX11B 256
PXMP4 213
PXMP2 166
ALDH3A2 164
ABCD1 141
ABCD3 88
ATAD1 5


rRNA processing
set rRNA processing
setSize 21
pANOVA 0.0142
s.dist 0.312
p.adjustANOVA 0.159


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
MT-ND1 412.0
MRM3 393.0
MT-ND2 375.0
MT-CO3 333.0
MT-CO1 328.0
MT-ND5 260.0
MT-CYB 202.0
MRM1 140.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
MTERF4 -2.0
NSUN4 -67.0
PRORP -91.0
TFB1M -201.0
MRM2 -224.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
MT-ND1 412.0
MRM3 393.0
MT-ND2 375.0
MT-CO3 333.0
MT-CO1 328.0
MT-ND5 260.0
MT-CYB 202.0
MRM1 140.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
MTERF4 -2.0
NSUN4 -67.0
PRORP -91.0
TFB1M -201.0
MRM2 -224.0
MT-ND3 -477.0


rRNA processing in the mitochondrion
set rRNA processing in the mitochondrion
setSize 21
pANOVA 0.0142
s.dist 0.312
p.adjustANOVA 0.159


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
MT-ND1 412.0
MRM3 393.0
MT-ND2 375.0
MT-CO3 333.0
MT-CO1 328.0
MT-ND5 260.0
MT-CYB 202.0
MRM1 140.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
MTERF4 -2.0
NSUN4 -67.0
PRORP -91.0
TFB1M -201.0
MRM2 -224.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
MT-ND1 412.0
MRM3 393.0
MT-ND2 375.0
MT-CO3 333.0
MT-CO1 328.0
MT-ND5 260.0
MT-CYB 202.0
MRM1 140.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
MTERF4 -2.0
NSUN4 -67.0
PRORP -91.0
TFB1M -201.0
MRM2 -224.0
MT-ND3 -477.0


Mitochondrial protein import
set Mitochondrial protein import
setSize 61
pANOVA 0.0191
s.dist -0.179
p.adjustANOVA 0.201


Top enriched genes
Top 20 genes
GeneID Gene Rank
TIMM21 -508
PAM16 -478
CMC4 -469
COA4 -460
DNAJC19 -457
GRPEL1 -449
COA6 -446
CHCHD7 -403
MTX2 -402
CHCHD4 -391
CHCHD2 -385
HSCB -381
TIMM10 -377
TIMM9 -372
TOMM40 -362
TIMM10B -359
TIMM22 -340
ATP5F1B -335
GRPEL2 -333
TOMM22 -328

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TIMM21 -508
PAM16 -478
CMC4 -469
COA4 -460
DNAJC19 -457
GRPEL1 -449
COA6 -446
CHCHD7 -403
MTX2 -402
CHCHD4 -391
CHCHD2 -385
HSCB -381
TIMM10 -377
TIMM9 -372
TOMM40 -362
TIMM10B -359
TIMM22 -340
ATP5F1B -335
GRPEL2 -333
TOMM22 -328
TIMM13 -327
HSPD1 -315
COQ2 -297
ATP5F1A -275
TIMM44 -248
TIMM8A -233
ATP5MC1 -231
PMPCA -222
GFER -217
PMPCB -196
DLD -185
CHCHD10 -180
CS -153
FXN -151
TIMM50 -145
TIMM8B -142
CHCHD5 -137
PITRM1 -88
BCS1L -61
ACO2 -44
CYC1 -17
TOMM70 10
TOMM20 48
MTX1 84
SLC25A6 161
TIMM17B 181
TIMM23 192
VDAC1 250
TIMM17A 263
SLC25A4 270
SLC25A12 273
SLC25A13 277
CMC2 293
CHCHD3 311
IDH3G 341
NDUFB8 376
SAMM50 394
COX19 405
HSPA9 413
COX17 437
TOMM7 462


Mitochondrial biogenesis
set Mitochondrial biogenesis
setSize 44
pANOVA 0.0215
s.dist -0.205
p.adjustANOVA 0.212


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLRMT -507
ATP5ME -462
ATP5PB -451
MTERF1 -440
ATP5PF -410
GLUD1 -407
MTX2 -402
ATP5PD -398
MICOS13 -397
MICOS10 -375
ATP5PO -368
SSBP1 -367
TMEM11 -336
ATP5F1B -335
ATP5MG -323
ATP5MF -322
ALAS1 -317
TFAM -299
ATP5F1E -293
ATP5F1A -275

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLRMT -507.0
ATP5ME -462.0
ATP5PB -451.0
MTERF1 -440.0
ATP5PF -410.0
GLUD1 -407.0
MTX2 -402.0
ATP5PD -398.0
MICOS13 -397.0
MICOS10 -375.0
ATP5PO -368.0
SSBP1 -367.0
TMEM11 -336.0
ATP5F1B -335.0
ATP5MG -323.0
ATP5MF -322.0
ALAS1 -317.0
TFAM -299.0
ATP5F1E -293.0
ATP5F1A -275.0
DMAC2L -261.0
SIRT3 -238.0
ATP5MC1 -231.0
TFB1M -201.0
ATP5F1C -200.0
POLG2 -179.0
ATP5F1D -171.0
SIRT5 -168.0
APOOL -160.0
TWNK 33.0
TFB2M 41.0
CHCHD6 71.5
MTX1 84.0
DNAJC11 210.0
SOD2 247.0
CYCS 251.0
APOO 288.0
CHCHD3 311.0
SAMM50 394.0
IMMT 410.0
HSPA9 413.0
IDH2 417.0
MT-ATP8 431.0
MT-ATP6 432.0


DNA Repair
set DNA Repair
setSize 7
pANOVA 0.0227
s.dist 0.499
p.adjustANOVA 0.212


Top enriched genes
Top 20 genes
GeneID Gene Rank
UNG 400
NTHL1 252
LIG3 233
DNA2 221
TOP3A 219
APEX1 173
MUTYH 40

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All member genes
GeneID Gene Rank
UNG 400
NTHL1 252
LIG3 233
DNA2 221
TOP3A 219
APEX1 173
MUTYH 40


Activation of gene expression by SREBF (SREBP)
set Activation of gene expression by SREBF (SREBP)
setSize 5
pANOVA 0.0276
s.dist 0.57
p.adjustANOVA 0.232


Top enriched genes
Top 20 genes
GeneID Gene Rank
IDI1 441
FASN 385
ACACA 227
GPAM 120
FDPS 102

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All member genes
GeneID Gene Rank
IDI1 441
FASN 385
ACACA 227
GPAM 120
FDPS 102


Regulation of cholesterol biosynthesis by SREBP (SREBF)
set Regulation of cholesterol biosynthesis by SREBP (SREBF)
setSize 5
pANOVA 0.0276
s.dist 0.57
p.adjustANOVA 0.232


Top enriched genes
Top 20 genes
GeneID Gene Rank
IDI1 441
FASN 385
ACACA 227
GPAM 120
FDPS 102

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDI1 441
FASN 385
ACACA 227
GPAM 120
FDPS 102


Organelle biogenesis and maintenance
set Organelle biogenesis and maintenance
setSize 45
pANOVA 0.0301
s.dist -0.191
p.adjustANOVA 0.24


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLRMT -507
ATP5ME -462
ATP5PB -451
MTERF1 -440
ATP5PF -410
GLUD1 -407
MTX2 -402
ATP5PD -398
MICOS13 -397
MICOS10 -375
ATP5PO -368
SSBP1 -367
TMEM11 -336
ATP5F1B -335
ATP5MG -323
ATP5MF -322
ALAS1 -317
TFAM -299
ATP5F1E -293
ATP5F1A -275

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLRMT -507.0
ATP5ME -462.0
ATP5PB -451.0
MTERF1 -440.0
ATP5PF -410.0
GLUD1 -407.0
MTX2 -402.0
ATP5PD -398.0
MICOS13 -397.0
MICOS10 -375.0
ATP5PO -368.0
SSBP1 -367.0
TMEM11 -336.0
ATP5F1B -335.0
ATP5MG -323.0
ATP5MF -322.0
ALAS1 -317.0
TFAM -299.0
ATP5F1E -293.0
ATP5F1A -275.0
DMAC2L -261.0
SIRT3 -238.0
ATP5MC1 -231.0
TFB1M -201.0
ATP5F1C -200.0
POLG2 -179.0
ATP5F1D -171.0
SIRT5 -168.0
APOOL -160.0
TWNK 33.0
TFB2M 41.0
CHCHD6 71.5
MTX1 84.0
PRKACA 172.0
DNAJC11 210.0
SOD2 247.0
CYCS 251.0
APOO 288.0
CHCHD3 311.0
SAMM50 394.0
IMMT 410.0
HSPA9 413.0
IDH2 417.0
MT-ATP8 431.0
MT-ATP6 432.0


Base Excision Repair
set Base Excision Repair
setSize 5
pANOVA 0.0546
s.dist 0.498
p.adjustANOVA 0.399


Top enriched genes
Top 20 genes
GeneID Gene Rank
UNG 400
NTHL1 252
LIG3 233
APEX1 173
MUTYH 40

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All member genes
GeneID Gene Rank
UNG 400
NTHL1 252
LIG3 233
APEX1 173
MUTYH 40


Resolution of Abasic Sites (AP sites)
set Resolution of Abasic Sites (AP sites)
setSize 5
pANOVA 0.0546
s.dist 0.498
p.adjustANOVA 0.399


Top enriched genes
Top 20 genes
GeneID Gene Rank
UNG 400
NTHL1 252
LIG3 233
APEX1 173
MUTYH 40

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UNG 400
NTHL1 252
LIG3 233
APEX1 173
MUTYH 40


Integration of energy metabolism
set Integration of energy metabolism
setSize 5
pANOVA 0.0624
s.dist 0.482
p.adjustANOVA 0.422


Top enriched genes
Top 20 genes
GeneID Gene Rank
FASN 385
ACACA 227
ACLY 211
PRKACA 172
AHCYL1 66

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All member genes
GeneID Gene Rank
FASN 385
ACACA 227
ACLY 211
PRKACA 172
AHCYL1 66


Transcriptional activation of mitochondrial biogenesis
set Transcriptional activation of mitochondrial biogenesis
setSize 16
pANOVA 0.0628
s.dist -0.271
p.adjustANOVA 0.422


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLRMT -507
MTERF1 -440
GLUD1 -407
SSBP1 -367
ATP5F1B -335
ALAS1 -317
TFAM -299
SIRT3 -238
TFB1M -201
POLG2 -179
SIRT5 -168
TWNK 33
TFB2M 41
SOD2 247
CYCS 251
IDH2 417

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLRMT -507
MTERF1 -440
GLUD1 -407
SSBP1 -367
ATP5F1B -335
ALAS1 -317
TFAM -299
SIRT3 -238
TFB1M -201
POLG2 -179
SIRT5 -168
TWNK 33
TFB2M 41
SOD2 247
CYCS 251
IDH2 417


Mitochondrial RNA degradation
set Mitochondrial RNA degradation
setSize 22
pANOVA 0.072
s.dist 0.224
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432
MT-ATP8 431
SLIRP 428
MT-ND1 412
LRPPRC 395
SUPV3L1 390
MT-ND2 375
MT-ND6 359
MT-CO3 333
MT-CO1 328
MT-ND5 260
MT-CYB 202
MT-CO2 116
MT-ND4 94
PNPT1 16
FASTKD5 -254
FASTKD2 -298
TBRG4 -348
FASTK -361
MT-ND3 -477

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432
MT-ATP8 431
SLIRP 428
MT-ND1 412
LRPPRC 395
SUPV3L1 390
MT-ND2 375
MT-ND6 359
MT-CO3 333
MT-CO1 328
MT-ND5 260
MT-CYB 202
MT-CO2 116
MT-ND4 94
PNPT1 16
FASTKD5 -254
FASTKD2 -298
TBRG4 -348
FASTK -361
MT-ND3 -477
GRSF1 -489
REXO2 -495


Glycine degradation
set Glycine degradation
setSize 6
pANOVA 0.0753
s.dist -0.421
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
GLDC -455
DLST -443
OGDH -379
GCSH -227
DLD -185
MRPS36 316

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All member genes
GeneID Gene Rank
GLDC -455
DLST -443
OGDH -379
GCSH -227
DLD -185
MRPS36 316


FASTK family proteins regulate processing and stability of mitochondrial RNAs
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 16
pANOVA 0.0785
s.dist 0.256
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432
MT-ATP8 431
MT-ND1 412
MT-ND2 375
MT-ND6 359
MT-CO3 333
MT-CO1 328
MT-ND5 260
MT-CYB 202
MT-CO2 116
MT-ND4 94
FASTKD5 -254
FASTKD2 -298
TBRG4 -348
FASTK -361
MT-ND3 -477

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432
MT-ATP8 431
MT-ND1 412
MT-ND2 375
MT-ND6 359
MT-CO3 333
MT-CO1 328
MT-ND5 260
MT-CYB 202
MT-CO2 116
MT-ND4 94
FASTKD5 -254
FASTKD2 -298
TBRG4 -348
FASTK -361
MT-ND3 -477


Metabolism of RNA
set Metabolism of RNA
setSize 45
pANOVA 0.0823
s.dist 0.153
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP6 432
MT-ATP8 431
SLIRP 428
TRIT1 427
MT-ND1 412
LRPPRC 395
MRM3 393
SUPV3L1 390
MT-ND2 375
MT-ND6 359
TRMT61B 348
TRNT1 335
MT-CO3 333
MT-CO1 328
DUS2 298
MT-ND5 260
NSUN2 223
MT-CYB 202
TRMU 145
MRM1 140

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP6 432.0
MT-ATP8 431.0
SLIRP 428.0
TRIT1 427.0
MT-ND1 412.0
LRPPRC 395.0
MRM3 393.0
SUPV3L1 390.0
MT-ND2 375.0
MT-ND6 359.0
TRMT61B 348.0
TRNT1 335.0
MT-CO3 333.0
MT-CO1 328.0
DUS2 298.0
MT-ND5 260.0
NSUN2 223.0
MT-CYB 202.0
TRMU 145.0
MRM1 140.0
MT-CO2 116.0
HSD17B10 97.0
MT-ND4 94.0
ELAC2 69.5
TRMT10C 37.0
PNPT1 16.0
MTO1 15.0
MTERF4 -2.0
NSUN4 -67.0
QTRT1 -83.0
PRORP -91.0
TRMT1 -173.0
TFB1M -201.0
PUS1 -206.0
MRM2 -224.0
FASTKD5 -254.0
GTPBP3 -258.0
FASTKD2 -298.0
TBRG4 -348.0
FASTK -361.0
THG1L -387.0
MT-ND3 -477.0
GRSF1 -489.0
REXO2 -495.0
TRMT5 -513.0


Innate Immune System
set Innate Immune System
setSize 24
pANOVA 0.0914
s.dist 0.202
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFC2 454
FTH1 340
BCL2 307
CASP8 262
ACAA1 234
ACLY 211
CAT 200
PRKACA 172
MAVS 171
NIT2 156
PRDX6 138
BCL2L1 114
ATAD3B 93
PRDX4 80
SNAP29 73
AHCYL1 66
STOM 49
RAB24 30
TOMM70 10
CYB5R3 9

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFC2 454
FTH1 340
BCL2 307
CASP8 262
ACAA1 234
ACLY 211
CAT 200
PRKACA 172
MAVS 171
NIT2 156
PRDX6 138
BCL2L1 114
ATAD3B 93
PRDX4 80
SNAP29 73
AHCYL1 66
STOM 49
RAB24 30
TOMM70 10
CYB5R3 9
PTGES2 -255
NLRX1 -292
MGST1 -417
ECSIT -452


Peroxisomal lipid metabolism
set Peroxisomal lipid metabolism
setSize 13
pANOVA 0.092
s.dist 0.272
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
MLYCD 278
ACAA1 234
AMACR 232
SCP2 218
HSD17B4 182
ALDH3A2 164
ABCD1 141
PHYH 133
NUDT19 131
EHHADH 124
CROT 103
CRAT -266
ECI2 -268

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MLYCD 278
ACAA1 234
AMACR 232
SCP2 218
HSD17B4 182
ALDH3A2 164
ABCD1 141
PHYH 133
NUDT19 131
EHHADH 124
CROT 103
CRAT -266
ECI2 -268


Developmental Biology
set Developmental Biology
setSize 5
pANOVA 0.093
s.dist 0.435
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
UNG 400
BCL2 307
PRKACA 172
HINT1 170
KARS1 -104

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All member genes
GeneID Gene Rank
UNG 400
BCL2 307
PRKACA 172
HINT1 170
KARS1 -104


Deubiquitination
set Deubiquitination
setSize 12
pANOVA 0.0962
s.dist 0.279
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
USP30 444.0
RHOT1 404.0
IDE 254.0
VDAC1 250.0
MUL1 187.0
MAVS 171.0
FKBP8 71.5
TOMM20 48.0
PTRH2 45.0
TOMM70 10.0
VDAC3 -103.0
VDAC2 -439.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
USP30 444.0
RHOT1 404.0
IDE 254.0
VDAC1 250.0
MUL1 187.0
MAVS 171.0
FKBP8 71.5
TOMM20 48.0
PTRH2 45.0
TOMM70 10.0
VDAC3 -103.0
VDAC2 -439.0


Ubiquinol biosynthesis
set Ubiquinol biosynthesis
setSize 12
pANOVA 0.0967
s.dist 0.279
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
COQ3 409
COQ6 401
COQ7 355
PDSS2 189
COQ9 185
STARD7 153
COQ5 146
COQ8A 53
PDSS1 51
COQ8B -86
HPDL -219
COQ2 -297

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All member genes
GeneID Gene Rank
COQ3 409
COQ6 401
COQ7 355
PDSS2 189
COQ9 185
STARD7 153
COQ5 146
COQ8A 53
PDSS1 51
COQ8B -86
HPDL -219
COQ2 -297


Peroxisomal protein import
set Peroxisomal protein import
setSize 19
pANOVA 0.0987
s.dist 0.221
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
MPV17 443
MLYCD 278
IDE 254
ACAA1 234
AMACR 232
SCP2 218
CAT 200
DHRS4 197
HSD17B4 182
PHYH 133
NUDT19 131
EHHADH 124
GSTK1 118
CROT 103
HMGCL -146
ACOT2 -204
CRAT -266
ECI2 -268
ECH1 -388

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MPV17 443
MLYCD 278
IDE 254
ACAA1 234
AMACR 232
SCP2 218
CAT 200
DHRS4 197
HSD17B4 182
PHYH 133
NUDT19 131
EHHADH 124
GSTK1 118
CROT 103
HMGCL -146
ACOT2 -204
CRAT -266
ECI2 -268
ECH1 -388


Metabolism of cofactors
set Metabolism of cofactors
setSize 13
pANOVA 0.0989
s.dist 0.266
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
COQ3 409
COQ6 401
COQ7 355
PDSS2 189
COQ9 185
STARD7 153
COQ5 146
COQ8A 53
PDSS1 51
SPR 31
COQ8B -86
HPDL -219
COQ2 -297

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COQ3 409
COQ6 401
COQ7 355
PDSS2 189
COQ9 185
STARD7 153
COQ5 146
COQ8A 53
PDSS1 51
SPR 31
COQ8B -86
HPDL -219
COQ2 -297


Mitochondrial Fatty Acid Beta-Oxidation
set Mitochondrial Fatty Acid Beta-Oxidation
setSize 26
pANOVA 0.103
s.dist -0.187
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
PCCA -510
HADH -485
ACAA2 -458
ACADS -396
ECI1 -392
NDUFAB1 -354
ECHS1 -274
PCCB -244
ACOT2 -204
MMAA -141
MMUT -135
ACADM -125
MECR -116
MCAT -87
ACOT13 -54
ACAD10 -34
DECR1 -31
ACSF2 -30
ACADVL 3
HADHA 56

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCCA -510
HADH -485
ACAA2 -458
ACADS -396
ECI1 -392
NDUFAB1 -354
ECHS1 -274
PCCB -244
ACOT2 -204
MMAA -141
MMUT -135
ACADM -125
MECR -116
MCAT -87
ACOT13 -54
ACAD10 -34
DECR1 -31
ACSF2 -30
ACADVL 3
HADHA 56
MCEE 65
THEM4 74
ACAD11 86
ACOT7 188
HADHB 313
DBI 344


Cellular response to chemical stress
set Cellular response to chemical stress
setSize 29
pANOVA 0.103
s.dist 0.178
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
PRDX3 445
COX6C 422
COX7B 381
COX4I1 369
MT-CO3 333
MT-CO1 328
COX7A2L 326
BCL2 307
CYCS 251
SOD2 247
SOD1 207
CAT 200
MUL1 187
PRDX6 138
TXNRD2 135
PRDX2 125
MT-CO2 116
BCL2L1 114
GSR 110
TXNRD1 76

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRDX3 445
COX6C 422
COX7B 381
COX4I1 369
MT-CO3 333
MT-CO1 328
COX7A2L 326
BCL2 307
CYCS 251
SOD2 247
SOD1 207
CAT 200
MUL1 187
PRDX6 138
TXNRD2 135
PRDX2 125
MT-CO2 116
BCL2L1 114
GSR 110
TXNRD1 76
GPX1 32
COX8A -187
COX5A -239
TXN2 -356
COX6B1 -413
NUDT2 -414
COX5B -459
NDUFA4 -497
COX7A2 -512


Cristae formation
set Cristae formation
setSize 29
pANOVA 0.104
s.dist -0.177
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5ME -462.0
ATP5PB -451.0
ATP5PF -410.0
MTX2 -402.0
ATP5PD -398.0
MICOS13 -397.0
MICOS10 -375.0
ATP5PO -368.0
TMEM11 -336.0
ATP5F1B -335.0
ATP5MG -323.0
ATP5MF -322.0
ATP5F1E -293.0
ATP5F1A -275.0
DMAC2L -261.0
ATP5MC1 -231.0
ATP5F1C -200.0
ATP5F1D -171.0
APOOL -160.0
CHCHD6 71.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5ME -462.0
ATP5PB -451.0
ATP5PF -410.0
MTX2 -402.0
ATP5PD -398.0
MICOS13 -397.0
MICOS10 -375.0
ATP5PO -368.0
TMEM11 -336.0
ATP5F1B -335.0
ATP5MG -323.0
ATP5MF -322.0
ATP5F1E -293.0
ATP5F1A -275.0
DMAC2L -261.0
ATP5MC1 -231.0
ATP5F1C -200.0
ATP5F1D -171.0
APOOL -160.0
CHCHD6 71.5
MTX1 84.0
DNAJC11 210.0
APOO 288.0
CHCHD3 311.0
SAMM50 394.0
IMMT 410.0
HSPA9 413.0
MT-ATP8 431.0
MT-ATP6 432.0


Neutrophil degranulation
set Neutrophil degranulation
setSize 15
pANOVA 0.109
s.dist 0.241
p.adjustANOVA 0.452


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFC2 454
FTH1 340
ACAA1 234
ACLY 211
CAT 200
NIT2 156
PRDX6 138
ATAD3B 93
PRDX4 80
SNAP29 73
STOM 49
RAB24 30
CYB5R3 9
PTGES2 -255
MGST1 -417

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFC2 454
FTH1 340
ACAA1 234
ACLY 211
CAT 200
NIT2 156
PRDX6 138
ATAD3B 93
PRDX4 80
SNAP29 73
STOM 49
RAB24 30
CYB5R3 9
PTGES2 -255
MGST1 -417


Respiratory electron transport
set Respiratory electron transport
setSize 135
pANOVA 0.11
s.dist 0.0855
p.adjustANOVA 0.452


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFB11 467
NDUFA1 465
NDUFB10 458
NDUFB4 456
NDUFC2 454
HIGD1A 451
CMC1 442
NDUFA10 439
COX17 437
NDUFB5 436
COX6C 422
UQCRQ 421
LYRM2 420
TMEM186 414
HSPA9 413
MT-ND1 412
NDUFS2 407
COX19 405
GOT2 399
ETFDH 398

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFB11 467
NDUFA1 465
NDUFB10 458
NDUFB4 456
NDUFC2 454
HIGD1A 451
CMC1 442
NDUFA10 439
COX17 437
NDUFB5 436
COX6C 422
UQCRQ 421
LYRM2 420
TMEM186 414
HSPA9 413
MT-ND1 412
NDUFS2 407
COX19 405
GOT2 399
ETFDH 398
PET100 391
UQCRB 387
NDUFB7 384
COX7B 381
TIMMDC1 379
NDUFB8 376
MT-ND2 375
COX11 374
COX4I1 369
OXA1L 368
MT-ND6 359
NDUFS3 354
NDUFA7 353
PNKD 350
UQCC2 343
NDUFS5 342
NDUFV3 337
MT-CO3 333
LETM1 331
MT-CO1 328
COX7A2L 326
COX16 324
COA5 322
NDUFA12 315
UQCRFS1 314
NDUFS7 310
NUBPL 308
NDUFA6 291
COX20 283
SLC25A13 277
SLC25A12 273
UQCRC1 271
MT-ND5 260
CYCS 251
UQCRC2 246
NDUFS1 230
NDUFS4 217
NDUFS8 208
MT-CYB 202
RAB5IF 186
NDUFAF4 137
MT-CO2 116
MT-ND4 94
UQCC1 92
ETFB 82
ETFA 44
CYC1 -17
FOXRED1 -20
NDUFAF6 -24
SURF1 -48
BCS1L -61
SCO1 -73
COX15 -76
UQCRH -80
TRAP1 -100
COQ10B -113
TMEM177 -114
HCCS -128
NDUFAF7 -130
SDHA -134
FXN -151
NFS1 -152
SLC25A22 -162
COA1 -166
TMEM126A -178
COX8A -187
TTC19 -195
SCO2 -198
SLC25A11 -207
NDUFV2 -220
ISCU -221
SDHD -226
COX18 -236
COX5A -239
NDUFA3 -251
NDUFV1 -262
SDHB -264
HIGD2A -270
NDUFAF5 -272
TMEM126B -280
COQ10A -288
NDUFS6 -303
UQCR10 -313
NDUFAF2 -324
SFXN4 -330
NDUFA13 -342
LYRM7 -346
ACAD9 -351
NDUFAB1 -354
NDUFA8 -369
UQCR11 -380
HSCB -381
NDUFA5 -406
MDH2 -409
NDUFAF3 -411
COX6B1 -413
NDUFB9 -419
NDUFA11 -424
NDUFAF1 -434
TACO1 -442
NDUFB6 -450
ECSIT -452
NDUFA9 -456
COX5B -459
NDUFB1 -467
SMIM20 -473
SDHC -475
MT-ND3 -477
NDUFA2 -486
LYRM4 -491
NDUFB3 -494
NDUFA4 -497
COA3 -504
TIMM21 -508
COX7A2 -512


Ub-specific processing proteases
set Ub-specific processing proteases
setSize 11
pANOVA 0.126
s.dist 0.268
p.adjustANOVA 0.506


Top enriched genes
Top 20 genes
GeneID Gene Rank
USP30 444.0
RHOT1 404.0
IDE 254.0
VDAC1 250.0
MUL1 187.0
FKBP8 71.5
TOMM20 48.0
PTRH2 45.0
TOMM70 10.0
VDAC3 -103.0
VDAC2 -439.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
USP30 444.0
RHOT1 404.0
IDE 254.0
VDAC1 250.0
MUL1 187.0
FKBP8 71.5
TOMM20 48.0
PTRH2 45.0
TOMM70 10.0
VDAC3 -103.0
VDAC2 -439.0


Detoxification of Reactive Oxygen Species
set Detoxification of Reactive Oxygen Species
setSize 13
pANOVA 0.139
s.dist 0.238
p.adjustANOVA 0.542


Top enriched genes
Top 20 genes
GeneID Gene Rank
PRDX3 445
CYCS 251
SOD2 247
SOD1 207
CAT 200
PRDX6 138
TXNRD2 135
PRDX2 125
GSR 110
TXNRD1 76
GPX1 32
TXN2 -356
NUDT2 -414

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRDX3 445
CYCS 251
SOD2 247
SOD1 207
CAT 200
PRDX6 138
TXNRD2 135
PRDX2 125
GSR 110
TXNRD1 76
GPX1 32
TXN2 -356
NUDT2 -414


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 5
pANOVA 0.148
s.dist 0.374
p.adjustANOVA 0.542


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACAA1 234
SCP2 218
HSD17B4 182
ABCD1 141
ACSL1 22

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAA1 234
SCP2 218
HSD17B4 182
ABCD1 141
ACSL1 22


alpha-linolenic acid (ALA) metabolism
set alpha-linolenic acid (ALA) metabolism
setSize 5
pANOVA 0.148
s.dist 0.374
p.adjustANOVA 0.542


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACAA1 234
SCP2 218
HSD17B4 182
ABCD1 141
ACSL1 22

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAA1 234
SCP2 218
HSD17B4 182
ABCD1 141
ACSL1 22


KEAP1-NFE2L2 pathway
set KEAP1-NFE2L2 pathway
setSize 5
pANOVA 0.15
s.dist 0.373
p.adjustANOVA 0.542


Top enriched genes
Top 20 genes
GeneID Gene Rank
BCL2 307
MUL1 187
BCL2L1 114
GSR 110
TXNRD1 76

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BCL2 307
MUL1 187
BCL2L1 114
GSR 110
TXNRD1 76


Regulated Necrosis
set Regulated Necrosis
setSize 5
pANOVA 0.152
s.dist 0.372
p.adjustANOVA 0.542


Top enriched genes
Top 20 genes
GeneID Gene Rank
BAK1 274
CASP8 262
CYCS 251
CASP3 226
BAX -223

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BAK1 274
CASP8 262
CYCS 251
CASP3 226
BAX -223


MAPK family signaling cascades
set MAPK family signaling cascades
setSize 5
pANOVA 0.166
s.dist -0.358
p.adjustANOVA 0.569


Top enriched genes
Top 20 genes
GeneID Gene Rank
LYPLA1 -472
ARL2 -421
PHB -386
BCL2L1 114
PRKACA 172

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LYPLA1 -472
ARL2 -421
PHB -386
BCL2L1 114
PRKACA 172


Cellular responses to stimuli
set Cellular responses to stimuli
setSize 43
pANOVA 0.178
s.dist 0.121
p.adjustANOVA 0.569


Top enriched genes
Top 20 genes
GeneID Gene Rank
HTRA2 463
HIGD1A 451
PRDX3 445
COX6C 422
HSPA9 413
COX7B 381
COX4I1 369
YME1L1 366
MT-CO3 333
MT-CO1 328
COX7A2L 326
BCL2 307
CYCS 251
SOD2 247
SOD1 207
CAT 200
MUL1 187
PRKACA 172
PRDX6 138
TXNRD2 135

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HTRA2 463
HIGD1A 451
PRDX3 445
COX6C 422
HSPA9 413
COX7B 381
COX4I1 369
YME1L1 366
MT-CO3 333
MT-CO1 328
COX7A2L 326
BCL2 307
CYCS 251
SOD2 247
SOD1 207
CAT 200
MUL1 187
PRKACA 172
PRDX6 138
TXNRD2 135
PRDX2 125
MT-CO2 116
BCL2L1 114
GSR 110
TXNRD1 76
GPX1 32
ACADVL 3
LONP1 -68
STOML2 -138
COX8A -187
SIRT3 -238
COX5A -239
HSPE1 -277
OMA1 -311
HSPD1 -315
TXN2 -356
PHB2 -389
COX6B1 -413
NUDT2 -414
COX5B -459
MRPL18 -463
NDUFA4 -497
COX7A2 -512


Mitochondrial protein degradation
set Mitochondrial protein degradation
setSize 95
pANOVA 0.18
s.dist -0.0836
p.adjustANOVA 0.569


Top enriched genes
Top 20 genes
GeneID Gene Rank
TRIAP1 -503
MRPL32 -490
NDUFA2 -486
HADH -485
ACAD8 -482
COX5B -459
NDUFB6 -450
ATP5PF -410
MDH2 -409
MRPL12 -408
GLUD1 -407
ATP5PD -398
ECI1 -392
ECH1 -388
CHCHD2 -385
OGDH -379
TIMM10 -377
TIMM9 -372
ATP5PO -368
SSBP1 -367

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRIAP1 -503
MRPL32 -490
NDUFA2 -486
HADH -485
ACAD8 -482
COX5B -459
NDUFB6 -450
ATP5PF -410
MDH2 -409
MRPL12 -408
GLUD1 -407
ATP5PD -398
ECI1 -392
ECH1 -388
CHCHD2 -385
OGDH -379
TIMM10 -377
TIMM9 -372
ATP5PO -368
SSBP1 -367
OXCT1 -349
PDHA1 -343
NDUFA13 -342
TIMM22 -340
ATP5F1B -335
ATP5MG -323
ALAS1 -317
HSPD1 -315
OMA1 -311
PDHB -310
TFAM -299
SHMT2 -290
AFG3L2 -287
CLPP -286
ATP5F1A -275
OPA1 -269
NDUFV1 -262
PCCB -244
COX5A -239
MICU2 -230
PMPCA -222
ACOT2 -204
ATP5F1C -200
DLD -185
ALDH2 -170
NADK2 -161
SMDT1 -159
BDH1 -156
PDK1 -155
CS -153
ME2 -75
LONP1 -68
SUCLG2 -60
OXSM -51
ACADSB -47
ACO2 -44
ARG2 -43
ALDH1B1 -32
ACAT1 -25
TWNK 33
HSD17B10 97
CLPX 111
MT-CO2 116
STARD7 153
SLC25A6 161
PRKACA 172
NDUFS1 230
IDH3A 244
UQCRC2 246
HMGCS2 255
MT-ND5 260
TIMM17A 263
IARS2 269
SPG7 276
MRPS2 279
DBT 318
MT-CO1 328
NDUFV3 337
SLC25A5 345
FH 351
NDUFS3 354
MT-ND6 359
MRPS10 365
YME1L1 366
COX4I1 369
MT-ND2 375
FECH 406
PRELID1 408
MT-ND1 412
HSPA9 413
IDH2 417
UQCRQ 421
MT-ATP6 432
ALDH18A1 433
HTRA2 463


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}
## Can't plot upregulated sets. Fewer than 5 found.

## [[1]]
## [[1]]$`UP genesets.tRNA processing in the mitochondrion`
## [1] "MT-ATP6" "MT-ATP8"
## 
## [[1]]$`DOWN genesets.Metabolism of proteins`
##   [1] "AARS2"      "ACAD8"      "ACADSB"     "ACAT1"      "ACO2"      
##   [6] "ACOT2"      "AFG3L2"     "ALAS1"      "ALDH1B1"    "ALDH2"     
##  [11] "ARF5"       "ARG2"       "ARL2"       "ATP5F1A"    "ATP5F1B"   
##  [16] "ATP5F1C"    "ATP5MG"     "ATP5PD"     "ATP5PF"     "ATP5PO"    
##  [21] "AURKAIP1"   "BDH1"       "CARS2"      "CHCHD1"     "CHCHD2"    
##  [26] "CLPP"       "CLPX"       "COX4I1"     "COX5A"      "COX5B"     
##  [31] "CS"         "DAP3"       "DARS2"      "DBT"        "DLAT"      
##  [36] "DLD"        "DLST"       "EARS2"      "ECH1"       "ECI1"      
##  [41] "ERAL1"      "ETFB"       "FARS2"      "FBXL4"      "FDX1"      
##  [46] "FECH"       "FH"         "FKBP8"      "GADD45GIP1" "GARS1"     
##  [51] "GCSH"       "GFM1"       "GFM2"       "GLUD1"      "HADH"      
##  [56] "HARS2"      "HMGCS2"     "HSD17B10"   "HSPA9"      "HSPD1"     
##  [61] "IARS2"      "IDE"        "IDH3A"      "KARS1"      "LARS2"     
##  [66] "LIAS"       "LIPT1"      "LONP1"      "MARS2"      "MAVS"      
##  [71] "MDH2"       "ME2"        "MICU2"      "MRPL1"      "MRPL10"    
##  [76] "MRPL11"     "MRPL12"     "MRPL13"     "MRPL14"     "MRPL15"    
##  [81] "MRPL16"     "MRPL17"     "MRPL18"     "MRPL19"     "MRPL2"     
##  [86] "MRPL21"     "MRPL22"     "MRPL23"     "MRPL24"     "MRPL27"    
##  [91] "MRPL28"     "MRPL3"      "MRPL30"     "MRPL32"     "MRPL33"    
##  [96] "MRPL34"     "MRPL36"     "MRPL37"     "MRPL38"     "MRPL39"    
## [101] "MRPL4"      "MRPL40"     "MRPL41"     "MRPL42"     "MRPL44"    
## [106] "MRPL46"     "MRPL47"     "MRPL48"     "MRPL49"     "MRPL50"    
## [111] "MRPL51"     "MRPL52"     "MRPL53"     "MRPL54"     "MRPL55"    
## [116] "MRPL57"     "MRPL58"     "MRPL9"      "MRPS10"     "MRPS11"    
## [121] "MRPS14"     "MRPS15"     "MRPS16"     "MRPS17"     "MRPS18A"   
## [126] "MRPS18B"    "MRPS18C"    "MRPS2"      "MRPS21"     "MRPS22"    
## [131] "MRPS23"     "MRPS24"     "MRPS25"     "MRPS26"     "MRPS27"    
## [136] "MRPS30"     "MRPS31"     "MRPS33"     "MRPS34"     "MRPS35"    
## [141] "MRPS36"     "MRPS5"      "MRPS6"      "MRPS7"      "MRPS9"     
## [146] "MRRF"       "MSRA"       "MSRB2"      "MSRB3"      "MT-CO1"    
## [151] "MT-CO2"     "MT-ND1"     "MT-ND2"     "MT-ND5"     "MT-ND6"    
## [156] "MTFMT"      "MTIF2"      "MTIF3"      "MTRF1L"     "MUL1"      
## [161] "NADK2"      "NARS2"      "NDUFA13"    "NDUFA2"     "NDUFAB1"   
## [166] "NDUFB6"     "NDUFS1"     "NDUFS3"     "NDUFV1"     "NDUFV3"    
## [171] "NFU1"       "OGDH"       "OMA1"       "OPA1"       "OXA1L"     
## [176] "OXCT1"      "OXSM"       "PARK7"      "PARS2"      "PCCB"      
## [181] "PDHA1"      "PDHB"       "PDK1"       "PGS1"       "PMPCA"     
## [186] "PPA2"       "PRELID1"    "PRKACA"     "PTCD3"      "PTRH2"     
## [191] "RAB24"      "RARS2"      "RHOT1"      "SARS2"      "SHMT2"     
## [196] "SLC25A5"    "SLC25A6"    "SMDT1"      "SPG7"       "SSBP1"     
## [201] "STARD7"     "STX17"      "SUCLG2"     "TARS2"      "TFAM"      
## [206] "TIMM10"     "TIMM17A"    "TIMM22"     "TIMM9"      "TOMM20"    
## [211] "TOMM70"     "TRIAP1"     "TSFM"       "TUFM"       "TWNK"      
## [216] "UQCRC2"     "VARS2"      "VDAC1"      "VDAC2"      "VDAC3"     
## [221] "YARS2"      "YME1L1"    
## 
## [[1]]$`DOWN genesets.Mitochondrial translation`
##  [1] "AURKAIP1"   "CHCHD1"     "DAP3"       "ERAL1"      "GADD45GIP1"
##  [6] "GFM1"       "GFM2"       "MRPL1"      "MRPL10"     "MRPL11"    
## [11] "MRPL12"     "MRPL13"     "MRPL14"     "MRPL15"     "MRPL16"    
## [16] "MRPL17"     "MRPL18"     "MRPL19"     "MRPL2"      "MRPL21"    
## [21] "MRPL22"     "MRPL23"     "MRPL24"     "MRPL27"     "MRPL28"    
## [26] "MRPL3"      "MRPL30"     "MRPL32"     "MRPL33"     "MRPL34"    
## [31] "MRPL36"     "MRPL37"     "MRPL38"     "MRPL39"     "MRPL4"     
## [36] "MRPL40"     "MRPL41"     "MRPL42"     "MRPL44"     "MRPL46"    
## [41] "MRPL47"     "MRPL48"     "MRPL49"     "MRPL50"     "MRPL51"    
## [46] "MRPL52"     "MRPL53"     "MRPL54"     "MRPL55"     "MRPL57"    
## [51] "MRPL58"     "MRPL9"      "MRPS10"     "MRPS11"     "MRPS14"    
## [56] "MRPS15"     "MRPS16"     "MRPS17"     "MRPS18A"    "MRPS18B"   
## [61] "MRPS18C"    "MRPS2"      "MRPS21"     "MRPS22"     "MRPS23"    
## [66] "MRPS24"     "MRPS25"     "MRPS26"     "MRPS27"     "MRPS30"    
## [71] "MRPS31"     "MRPS33"     "MRPS34"     "MRPS35"     "MRPS36"    
## [76] "MRPS5"      "MRPS6"      "MRPS7"      "MRPS9"      "MRRF"      
## [81] "MTFMT"      "MTIF2"      "MTIF3"      "MTRF1L"     "OXA1L"     
## [86] "PTCD3"      "TSFM"       "TUFM"      
## 
## [[1]]$`DOWN genesets.Mitochondrial translation elongation`
##  [1] "AURKAIP1"   "CHCHD1"     "DAP3"       "ERAL1"      "GADD45GIP1"
##  [6] "GFM1"       "MRPL1"      "MRPL10"     "MRPL11"     "MRPL12"    
## [11] "MRPL13"     "MRPL14"     "MRPL15"     "MRPL16"     "MRPL17"    
## [16] "MRPL18"     "MRPL19"     "MRPL2"      "MRPL21"     "MRPL22"    
## [21] "MRPL23"     "MRPL24"     "MRPL27"     "MRPL28"     "MRPL3"     
## [26] "MRPL30"     "MRPL32"     "MRPL33"     "MRPL34"     "MRPL36"    
## [31] "MRPL37"     "MRPL38"     "MRPL39"     "MRPL4"      "MRPL40"    
## [36] "MRPL41"     "MRPL42"     "MRPL44"     "MRPL46"     "MRPL47"    
## [41] "MRPL48"     "MRPL49"     "MRPL50"     "MRPL51"     "MRPL52"    
## [46] "MRPL53"     "MRPL54"     "MRPL55"     "MRPL57"     "MRPL58"    
## [51] "MRPL9"      "MRPS10"     "MRPS11"     "MRPS14"     "MRPS15"    
## [56] "MRPS16"     "MRPS17"     "MRPS18A"    "MRPS18B"    "MRPS18C"   
## [61] "MRPS2"      "MRPS21"     "MRPS22"     "MRPS23"     "MRPS24"    
## [66] "MRPS25"     "MRPS26"     "MRPS27"     "MRPS30"     "MRPS31"    
## [71] "MRPS33"     "MRPS34"     "MRPS35"     "MRPS36"     "MRPS5"     
## [76] "MRPS6"      "MRPS7"      "MRPS9"      "OXA1L"      "PTCD3"     
## [81] "TSFM"       "TUFM"      
## 
## [[1]]$`DOWN genesets.Mitochondrial translation initiation`
##  [1] "AURKAIP1"   "CHCHD1"     "DAP3"       "ERAL1"      "GADD45GIP1"
##  [6] "MRPL1"      "MRPL10"     "MRPL11"     "MRPL12"     "MRPL13"    
## [11] "MRPL14"     "MRPL15"     "MRPL16"     "MRPL17"     "MRPL18"    
## [16] "MRPL19"     "MRPL2"      "MRPL21"     "MRPL22"     "MRPL23"    
## [21] "MRPL24"     "MRPL27"     "MRPL28"     "MRPL3"      "MRPL30"    
## [26] "MRPL32"     "MRPL33"     "MRPL34"     "MRPL36"     "MRPL37"    
## [31] "MRPL38"     "MRPL39"     "MRPL4"      "MRPL40"     "MRPL41"    
## [36] "MRPL42"     "MRPL44"     "MRPL46"     "MRPL47"     "MRPL48"    
## [41] "MRPL49"     "MRPL50"     "MRPL51"     "MRPL52"     "MRPL53"    
## [46] "MRPL54"     "MRPL55"     "MRPL57"     "MRPL58"     "MRPL9"     
## [51] "MRPS10"     "MRPS11"     "MRPS14"     "MRPS15"     "MRPS16"    
## [56] "MRPS17"     "MRPS18A"    "MRPS18B"    "MRPS18C"    "MRPS2"     
## [61] "MRPS21"     "MRPS22"     "MRPS23"     "MRPS24"     "MRPS25"    
## [66] "MRPS26"     "MRPS27"     "MRPS30"     "MRPS31"     "MRPS33"    
## [71] "MRPS34"     "MRPS35"     "MRPS36"     "MRPS5"      "MRPS6"     
## [76] "MRPS7"      "MRPS9"      "MTFMT"      "MTIF2"      "MTIF3"     
## [81] "OXA1L"      "PTCD3"     
## 
## [[1]]$`DOWN genesets.Mitochondrial translation termination`
##  [1] "AURKAIP1"   "CHCHD1"     "DAP3"       "ERAL1"      "GADD45GIP1"
##  [6] "GFM2"       "MRPL1"      "MRPL10"     "MRPL11"     "MRPL12"    
## [11] "MRPL13"     "MRPL14"     "MRPL15"     "MRPL16"     "MRPL17"    
## [16] "MRPL18"     "MRPL19"     "MRPL2"      "MRPL21"     "MRPL22"    
## [21] "MRPL23"     "MRPL24"     "MRPL27"     "MRPL28"     "MRPL3"     
## [26] "MRPL30"     "MRPL32"     "MRPL33"     "MRPL34"     "MRPL36"    
## [31] "MRPL37"     "MRPL38"     "MRPL39"     "MRPL4"      "MRPL40"    
## [36] "MRPL41"     "MRPL42"     "MRPL44"     "MRPL46"     "MRPL47"    
## [41] "MRPL48"     "MRPL49"     "MRPL50"     "MRPL51"     "MRPL52"    
## [46] "MRPL53"     "MRPL54"     "MRPL55"     "MRPL57"     "MRPL58"    
## [51] "MRPL9"      "MRPS10"     "MRPS11"     "MRPS14"     "MRPS15"    
## [56] "MRPS16"     "MRPS17"     "MRPS18A"    "MRPS18B"    "MRPS18C"   
## [61] "MRPS2"      "MRPS21"     "MRPS22"     "MRPS23"     "MRPS24"    
## [66] "MRPS25"     "MRPS26"     "MRPS27"     "MRPS30"     "MRPS31"    
## [71] "MRPS33"     "MRPS34"     "MRPS35"     "MRPS36"     "MRPS5"     
## [76] "MRPS6"      "MRPS7"      "MRPS9"      "MRRF"       "MTRF1L"    
## [81] "OXA1L"      "PTCD3"     
## 
## [[1]]$`DOWN genesets.Translation`
##   [1] "AARS2"      "AURKAIP1"   "CARS2"      "CHCHD1"     "DAP3"      
##   [6] "DARS2"      "EARS2"      "ERAL1"      "FARS2"      "GADD45GIP1"
##  [11] "GARS1"      "GFM1"       "GFM2"       "HARS2"      "IARS2"     
##  [16] "KARS1"      "LARS2"      "MARS2"      "MRPL1"      "MRPL10"    
##  [21] "MRPL11"     "MRPL12"     "MRPL13"     "MRPL14"     "MRPL15"    
##  [26] "MRPL16"     "MRPL17"     "MRPL18"     "MRPL19"     "MRPL2"     
##  [31] "MRPL21"     "MRPL22"     "MRPL23"     "MRPL24"     "MRPL27"    
##  [36] "MRPL28"     "MRPL3"      "MRPL30"     "MRPL32"     "MRPL33"    
##  [41] "MRPL34"     "MRPL36"     "MRPL37"     "MRPL38"     "MRPL39"    
##  [46] "MRPL4"      "MRPL40"     "MRPL41"     "MRPL42"     "MRPL44"    
##  [51] "MRPL46"     "MRPL47"     "MRPL48"     "MRPL49"     "MRPL50"    
##  [56] "MRPL51"     "MRPL52"     "MRPL53"     "MRPL54"     "MRPL55"    
##  [61] "MRPL57"     "MRPL58"     "MRPL9"      "MRPS10"     "MRPS11"    
##  [66] "MRPS14"     "MRPS15"     "MRPS16"     "MRPS17"     "MRPS18A"   
##  [71] "MRPS18B"    "MRPS18C"    "MRPS2"      "MRPS21"     "MRPS22"    
##  [76] "MRPS23"     "MRPS24"     "MRPS25"     "MRPS26"     "MRPS27"    
##  [81] "MRPS30"     "MRPS31"     "MRPS33"     "MRPS34"     "MRPS35"    
##  [86] "MRPS36"     "MRPS5"      "MRPS6"      "MRPS7"      "MRPS9"     
##  [91] "MRRF"       "MTFMT"      "MTIF2"      "MTIF3"      "MTRF1L"    
##  [96] "NARS2"      "OXA1L"      "PARS2"      "PPA2"       "PTCD3"     
## [101] "RARS2"      "SARS2"      "TARS2"      "TSFM"       "TUFM"      
## [106] "VARS2"      "YARS2"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.6.0 (2026-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
## [1] gtools_3.9.5     kableExtra_1.4.0 mitch_1.24.0    
## 
## loaded via a namespace (and not attached):
##  [1] gtable_0.3.6          beeswarm_0.4.0        bslib_0.11.0         
##  [4] xfun_0.57             ggplot2_4.0.3         htmlwidgets_1.6.4    
##  [7] caTools_1.18.3        GGally_2.4.0          lattice_0.22-9       
## [10] vctrs_0.7.3           tools_4.6.0           bitops_1.0-9         
## [13] generics_0.1.4        parallel_4.6.0        tibble_3.3.1         
## [16] pkgconfig_2.0.3       KernSmooth_2.23-26    RColorBrewer_1.1-3   
## [19] S7_0.2.2              lifecycle_1.0.5       compiler_4.6.0       
## [22] farver_2.1.2          stringr_1.6.0         textshaping_1.0.5    
## [25] gplots_3.3.0          httpuv_1.6.17         sass_0.4.10          
## [28] htmltools_0.5.9       yaml_2.3.12           jquerylib_0.1.4      
## [31] later_1.4.8           pillar_1.11.1         tidyr_1.3.2          
## [34] MASS_7.3-65           cachem_1.1.0          mime_0.13            
## [37] ggstats_0.13.0        network_1.20.0        tidyselect_1.2.1     
## [40] digest_0.6.39         stringi_1.8.7         dplyr_1.2.1          
## [43] reshape2_1.4.5        purrr_1.2.2           fastmap_1.2.0        
## [46] grid_4.6.0            cli_3.6.6             magrittr_2.0.5       
## [49] dichromat_2.0-0.1     withr_3.0.2           scales_1.4.0         
## [52] promises_1.5.0        rmarkdown_2.31        otel_0.2.0           
## [55] gridExtra_2.3         coda_0.19-4.1         shiny_1.13.0         
## [58] evaluate_1.0.5        knitr_1.51            viridisLite_0.4.3    
## [61] rlang_1.2.0           Rcpp_1.1.1-1.1        xtable_1.8-8         
## [64] glue_1.8.1            echarts4r_0.5.0       xml2_1.5.2           
## [67] jsonlite_2.0.0        svglite_2.2.2         rstudioapi_0.18.0    
## [70] R6_2.6.1              plyr_1.8.9            statnet.common_4.13.0
## [73] systemfonts_1.3.2

END of report