Mitch Report

date generated: 2025-10-31

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
A2M	1.4763246
A2ML1	0.2943020
AAAS	0.5521507
AACS	-0.0023486
AADAT	0.4744042
AAGAB	-1.8808502

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2810
num_genes_in_profile	7745
duplicated_genes_present	0
num_profile_genes_in_sets	5441
num_profile_genes_not_in_sets	2304

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2810
num_genesets_excluded	1490
num_genesets_included	1320

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
rRNA modification in the mitochondrion	13	8.24e-08	0.859	1.72e-06
Mitochondrial ribosome-associated quality control	89	1.48e-41	0.826	2.61e-38
RUNX2 regulates genes involved in cell migration	5	1.76e-03	-0.808	9.99e-03
Classical antibody-mediated complement activation	6	6.92e-04	0.800	4.34e-03
Creation of C4 and C2 activators	6	6.92e-04	0.800	4.34e-03
Initial triggering of complement	9	6.95e-05	0.766	6.57e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	1.12e-12	0.763	7.53e-11
IP3 and IP4 transport between cytosol and nucleus	29	1.12e-12	0.763	7.53e-11
IP6 and IP7 transport between cytosol and nucleus	29	1.12e-12	0.763	7.53e-11
IPs transport between nucleus and cytosol	29	1.12e-12	0.763	7.53e-11
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	1.12e-12	0.763	7.53e-11
PDH complex synthesizes acetyl-CoA from PYR	5	4.23e-03	0.739	2.07e-02
Regulation of pyruvate dehydrogenase (PDH) complex	12	1.19e-05	0.730	1.54e-04
SUMOylation of SUMOylation proteins	31	3.77e-12	0.721	2.21e-10
RSK activation	5	5.40e-03	-0.719	2.56e-02
Ketone body metabolism	7	1.07e-03	0.714	6.31e-03
Propionyl-CoA catabolism	5	5.85e-03	0.712	2.75e-02
Synthesis of Ketone Bodies	6	2.56e-03	0.711	1.37e-02
Diseases of branched-chain amino acid catabolism	12	2.44e-05	0.704	2.86e-04
Mitochondrial iron-sulfur cluster biogenesis	13	1.16e-05	0.702	1.53e-04
NEP/NS2 Interacts with the Cellular Export Machinery	31	1.62e-11	0.699	7.49e-10
Protein lipoylation	9	3.03e-04	0.696	2.22e-03
Mitochondrial translation	111	1.01e-36	0.695	8.86e-34
Vpr-mediated nuclear import of PICs	33	5.61e-12	0.693	2.99e-10
SUMOylation of ubiquitinylation proteins	33	9.15e-12	0.686	4.59e-10
Mitochondrial translation termination	101	1.22e-32	0.685	7.14e-30
Mitochondrial translation elongation	100	2.57e-32	0.685	1.12e-29
Maturation of TCA enzymes and regulation of TCA cycle	19	2.41e-07	0.684	4.60e-06
Mitochondrial translation initiation	100	3.19e-32	0.684	1.12e-29
Beta-oxidation of pristanoyl-CoA	6	3.80e-03	0.682	1.93e-02
Postmitotic nuclear pore complex (NPC) reformation	25	4.33e-09	0.678	1.17e-07
Transport of Ribonucleoproteins into the Host Nucleus	31	6.64e-11	0.678	2.48e-09
Diseases of hemostasis	5	8.72e-03	0.677	3.89e-02
Nef mediated downregulation of MHC class I complex cell surface expression	9	4.46e-04	-0.676	3.03e-03
Branched-chain ketoacid dehydrogenase kinase deficiency	5	9.15e-03	0.673	4.03e-02
Negative feedback regulation of MAPK pathway	5	9.39e-03	-0.671	4.11e-02
Citric acid cycle (TCA cycle)	33	3.74e-11	0.665	1.49e-09
Ubiquinol biosynthesis	12	7.60e-05	0.660	7.03e-04
Mitochondrial tRNA aminoacylation	21	1.67e-07	0.660	3.30e-06
Nuclear import of Rev protein	33	5.71e-11	0.659	2.18e-09
Export of Viral Ribonucleoproteins from Nucleus	32	1.17e-10	0.658	4.20e-09
Transport of the SLBP Dependant Mature mRNA	34	3.34e-11	0.657	1.44e-09
Transport of the SLBP independent Mature mRNA	34	3.34e-11	0.657	1.44e-09
Rev-mediated nuclear export of HIV RNA	34	5.29e-11	0.650	2.07e-09
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	5	1.34e-02	-0.639	5.45e-02
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	5	1.34e-02	-0.639	5.45e-02
Interactions of Vpr with host cellular proteins	36	3.35e-11	0.639	1.44e-09
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	5	1.36e-02	0.637	5.51e-02
Mucopolysaccharidoses	9	9.37e-04	0.637	5.66e-03
Strand-asynchronous mitochondrial DNA replication	10	4.97e-04	0.636	3.29e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
rRNA modification in the mitochondrion	13	8.24e-08	0.859000	1.72e-06
Mitochondrial ribosome-associated quality control	89	1.48e-41	0.826000	2.61e-38
RUNX2 regulates genes involved in cell migration	5	1.76e-03	-0.808000	9.99e-03
Classical antibody-mediated complement activation	6	6.92e-04	0.800000	4.34e-03
Creation of C4 and C2 activators	6	6.92e-04	0.800000	4.34e-03
Initial triggering of complement	9	6.95e-05	0.766000	6.57e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	1.12e-12	0.763000	7.53e-11
IP3 and IP4 transport between cytosol and nucleus	29	1.12e-12	0.763000	7.53e-11
IP6 and IP7 transport between cytosol and nucleus	29	1.12e-12	0.763000	7.53e-11
IPs transport between nucleus and cytosol	29	1.12e-12	0.763000	7.53e-11
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	1.12e-12	0.763000	7.53e-11
PDH complex synthesizes acetyl-CoA from PYR	5	4.23e-03	0.739000	2.07e-02
Regulation of pyruvate dehydrogenase (PDH) complex	12	1.19e-05	0.730000	1.54e-04
SUMOylation of SUMOylation proteins	31	3.77e-12	0.721000	2.21e-10
RSK activation	5	5.40e-03	-0.719000	2.56e-02
Ketone body metabolism	7	1.07e-03	0.714000	6.31e-03
Propionyl-CoA catabolism	5	5.85e-03	0.712000	2.75e-02
Synthesis of Ketone Bodies	6	2.56e-03	0.711000	1.37e-02
Diseases of branched-chain amino acid catabolism	12	2.44e-05	0.704000	2.86e-04
Mitochondrial iron-sulfur cluster biogenesis	13	1.16e-05	0.702000	1.53e-04
NEP/NS2 Interacts with the Cellular Export Machinery	31	1.62e-11	0.699000	7.49e-10
Protein lipoylation	9	3.03e-04	0.696000	2.22e-03
Mitochondrial translation	111	1.01e-36	0.695000	8.86e-34
Vpr-mediated nuclear import of PICs	33	5.61e-12	0.693000	2.99e-10
SUMOylation of ubiquitinylation proteins	33	9.15e-12	0.686000	4.59e-10
Mitochondrial translation termination	101	1.22e-32	0.685000	7.14e-30
Mitochondrial translation elongation	100	2.57e-32	0.685000	1.12e-29
Maturation of TCA enzymes and regulation of TCA cycle	19	2.41e-07	0.684000	4.60e-06
Mitochondrial translation initiation	100	3.19e-32	0.684000	1.12e-29
Beta-oxidation of pristanoyl-CoA	6	3.80e-03	0.682000	1.93e-02
Postmitotic nuclear pore complex (NPC) reformation	25	4.33e-09	0.678000	1.17e-07
Transport of Ribonucleoproteins into the Host Nucleus	31	6.64e-11	0.678000	2.48e-09
Diseases of hemostasis	5	8.72e-03	0.677000	3.89e-02
Nef mediated downregulation of MHC class I complex cell surface expression	9	4.46e-04	-0.676000	3.03e-03
Branched-chain ketoacid dehydrogenase kinase deficiency	5	9.15e-03	0.673000	4.03e-02
Negative feedback regulation of MAPK pathway	5	9.39e-03	-0.671000	4.11e-02
Citric acid cycle (TCA cycle)	33	3.74e-11	0.665000	1.49e-09
Ubiquinol biosynthesis	12	7.60e-05	0.660000	7.03e-04
Mitochondrial tRNA aminoacylation	21	1.67e-07	0.660000	3.30e-06
Nuclear import of Rev protein	33	5.71e-11	0.659000	2.18e-09
Export of Viral Ribonucleoproteins from Nucleus	32	1.17e-10	0.658000	4.20e-09
Transport of the SLBP Dependant Mature mRNA	34	3.34e-11	0.657000	1.44e-09
Transport of the SLBP independent Mature mRNA	34	3.34e-11	0.657000	1.44e-09
Rev-mediated nuclear export of HIV RNA	34	5.29e-11	0.650000	2.07e-09
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	5	1.34e-02	-0.639000	5.45e-02
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	5	1.34e-02	-0.639000	5.45e-02
Interactions of Vpr with host cellular proteins	36	3.35e-11	0.639000	1.44e-09
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	5	1.36e-02	0.637000	5.51e-02
Mucopolysaccharidoses	9	9.37e-04	0.637000	5.66e-03
Strand-asynchronous mitochondrial DNA replication	10	4.97e-04	0.636000	3.29e-03
Nuclear Pore Complex (NPC) Disassembly	34	2.76e-10	0.626000	9.34e-09
DNA Damage Reversal	6	8.77e-03	-0.618000	3.89e-02
Reversal of alkylation damage by DNA dioxygenases	6	8.77e-03	-0.618000	3.89e-02
Lysine catabolism	8	2.76e-03	0.611000	1.46e-02
Branched-chain amino acid catabolism	20	3.13e-06	0.602000	4.75e-05
Prevention of phagosomal-lysosomal fusion	6	1.08e-02	-0.601000	4.62e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	16	3.30e-05	-0.600000	3.60e-04
Suppression of phagosomal maturation	9	1.88e-03	-0.598000	1.06e-02
Activation of caspases through apoptosome-mediated cleavage	6	1.16e-02	-0.595000	4.88e-02
Interactions of Rev with host cellular proteins	36	7.40e-10	0.593000	2.45e-08
Keratan sulfate degradation	6	1.38e-02	0.580000	5.57e-02
Regulation of commissural axon pathfinding by SLIT and ROBO	7	8.29e-03	0.576000	3.72e-02
tRNA modification in the mitochondrion	11	9.43e-04	0.576000	5.66e-03
Protein repair	5	2.59e-02	0.576000	9.13e-02
Formation of axial mesoderm	5	2.69e-02	0.572000	9.45e-02
SUMOylation of DNA replication proteins	40	7.63e-10	0.562000	2.48e-08
Frs2-mediated activation	8	6.35e-03	-0.557000	2.96e-02
SUMOylation of RNA binding proteins	39	2.11e-09	0.555000	6.07e-08
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	2.41e-03	0.554000	1.31e-02
Beta-oxidation of very long chain fatty acids	9	4.00e-03	0.554000	2.00e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	5	3.21e-02	-0.554000	1.07e-01
Prolonged ERK activation events	10	2.53e-03	-0.552000	1.37e-02
Synthesis, secretion, and deacylation of Ghrelin	6	1.98e-02	-0.549000	7.39e-02
Creatine metabolism	6	2.11e-02	-0.544000	7.78e-02
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	5	3.57e-02	-0.542000	1.16e-01
Formation of tubulin folding intermediates by CCT/TriC	20	3.29e-05	-0.537000	3.60e-04
The activation of arylsulfatases	5	3.81e-02	0.536000	1.22e-01
Defective HLCS causes multiple carboxylase deficiency	7	1.43e-02	0.535000	5.65e-02
Defects in biotin (Btn) metabolism	7	1.43e-02	0.535000	5.65e-02
The role of Nef in HIV-1 replication and disease pathogenesis	20	3.54e-05	-0.534000	3.82e-04
Caspase-mediated cleavage of cytoskeletal proteins	10	3.57e-03	-0.532000	1.84e-02
Synthesis of PIPs at the Golgi membrane	14	6.03e-04	-0.530000	3.93e-03
Transport of Mature mRNA Derived from an Intronless Transcript	41	1.02e-08	0.517000	2.52e-07
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.02e-08	0.517000	2.52e-07
Viral Messenger RNA Synthesis	42	7.00e-09	0.517000	1.81e-07
Scavenging of heme from plasma	12	1.95e-03	0.517000	1.09e-02
Glyoxylate metabolism and glycine degradation	10	4.70e-03	0.516000	2.28e-02
NS1 Mediated Effects on Host Pathways	38	4.00e-08	0.515000	9.25e-07
Synthesis of glycosylphosphatidylinositol (GPI)	10	5.05e-03	0.512000	2.41e-02
G beta:gamma signalling through PI3Kgamma	11	3.32e-03	-0.512000	1.73e-02
SUMOylation of chromatin organization proteins	46	2.34e-09	0.509000	6.64e-08
Synthesis of PIPs at the early endosome membrane	14	1.01e-03	-0.508000	5.99e-03
Complex III assembly	24	2.02e-05	0.503000	2.46e-04
Nef Mediated CD4 Down-regulation	7	2.20e-02	-0.500000	8.00e-02
Nuclear Envelope Breakdown	49	1.64e-09	0.498000	4.97e-08
Synthesis of diphthamide-EEF2	5	5.48e-02	-0.496000	1.58e-01
Glucagon-type ligand receptors	9	1.01e-02	-0.495000	4.40e-02
Synthesis of PIPs at the late endosome membrane	9	1.07e-02	-0.491000	4.61e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	4.01e-02	0.484000	1.28e-01
G-protein beta:gamma signalling	14	1.89e-03	-0.480000	1.06e-02
Interleukin-1 processing	5	6.42e-02	-0.478000	1.77e-01
Folding of actin by CCT/TriC	10	8.97e-03	-0.477000	3.97e-02
Sulfide oxidation to sulfate	5	6.57e-02	0.475000	1.80e-01
Prostacyclin signalling through prostacyclin receptor	7	2.97e-02	-0.475000	1.03e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	4.43e-02	0.474000	1.37e-01
CD22 mediated BCR regulation	5	6.76e-02	0.472000	1.85e-01
Complement cascade	19	3.79e-04	0.471000	2.65e-03
Regulation of Complement cascade	19	3.79e-04	0.471000	2.65e-03
Recycling of eIF2:GDP	8	2.12e-02	-0.471000	7.78e-02
Formation of a pool of free 40S subunits	92	7.37e-15	-0.470000	9.26e-13
Negative regulation of FLT3	7	3.19e-02	-0.469000	1.07e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	13	3.46e-03	-0.468000	1.80e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	7.00e-02	0.468000	1.90e-01
Transport of connexons to the plasma membrane	14	2.54e-03	-0.466000	1.37e-02
Activation of AMPK downstream of NMDARs	19	4.49e-04	-0.465000	3.05e-03
OAS antiviral response	7	3.32e-02	0.465000	1.10e-01
Regulation of PTEN localization	6	4.95e-02	-0.463000	1.48e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	8	2.39e-02	-0.461000	8.48e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	8	2.39e-02	-0.461000	8.48e-02
tRNA processing in the nucleus	47	4.74e-08	0.461000	1.04e-06
Glycine degradation	6	5.10e-02	0.460000	1.52e-01
Response of EIF2AK1 (HRI) to heme deficiency	7	3.53e-02	-0.460000	1.15e-01
Induction of Cell-Cell Fusion	5	7.53e-02	-0.459000	2.00e-01
Mitochondrial protein import	60	8.23e-10	0.459000	2.63e-08
Nef Mediated CD8 Down-regulation	6	5.27e-02	-0.457000	1.54e-01
Metabolism of cofactors	20	4.13e-04	0.456000	2.85e-03
Peptide chain elongation	81	1.76e-12	-0.454000	1.11e-10
Interaction between L1 and Ankyrins	10	1.30e-02	-0.454000	5.33e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	103	2.05e-15	-0.454000	3.27e-13
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	85	5.32e-13	-0.454000	5.19e-11
Metabolism of non-coding RNA	49	4.16e-08	0.453000	9.25e-07
snRNP Assembly	49	4.16e-08	0.453000	9.25e-07
Activation of the AP-1 family of transcription factors	6	5.47e-02	-0.453000	1.58e-01
L13a-mediated translational silencing of Ceruloplasmin expression	102	3.30e-15	-0.453000	4.45e-13
Processing of SMDT1	16	1.76e-03	0.452000	9.99e-03
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	82	1.73e-12	-0.452000	1.11e-10
VLDLR internalisation and degradation	9	1.93e-02	-0.451000	7.27e-02
Gap junction assembly	15	2.54e-03	-0.450000	1.37e-02
IRAK1 recruits IKK complex	9	1.94e-02	-0.450000	7.29e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	9	1.94e-02	-0.450000	7.29e-02
Formation of the ternary complex, and subsequently, the 43S complex	50	4.02e-08	-0.449000	9.25e-07
RHO GTPases Activate WASPs and WAVEs	30	2.11e-05	-0.449000	2.50e-04
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	7	3.99e-02	-0.449000	1.27e-01
Urea cycle	7	4.10e-02	0.446000	1.30e-01
VxPx cargo-targeting to cilium	14	4.03e-03	-0.444000	2.00e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	7.87e-03	-0.443000	3.55e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	87	1.05e-12	-0.443000	7.53e-11
Lipophagy	8	3.02e-02	-0.443000	1.03e-01
Ubiquitin-dependent degradation of Cyclin D	35	6.16e-06	-0.442000	8.79e-05
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	89	6.95e-13	-0.441000	6.43e-11
Mitochondrial Fatty Acid Beta-Oxidation	30	2.99e-05	0.441000	3.35e-04
Cap-dependent Translation Initiation	110	1.85e-15	-0.440000	3.25e-13
Eukaryotic Translation Initiation	110	1.85e-15	-0.440000	3.25e-13
Selenocysteine synthesis	82	6.76e-12	-0.439000	3.49e-10
Response of EIF2AK4 (GCN2) to amino acid deficiency	87	2.51e-12	-0.435000	1.52e-10
Transport of nucleotide sugars	7	4.78e-02	0.432000	1.45e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	33	1.79e-05	-0.432000	2.23e-04
AKT phosphorylates targets in the nucleus	7	4.83e-02	-0.431000	1.46e-01
G beta:gamma signalling through CDC42	8	3.49e-02	-0.431000	1.15e-01
HCMV Late Events	60	8.44e-09	0.431000	2.15e-07
Ribosome-associated quality control	130	4.03e-17	-0.429000	1.18e-14
Eukaryotic Translation Elongation	85	1.11e-11	-0.427000	5.44e-10
Eukaryotic Translation Termination	84	1.56e-11	-0.426000	7.42e-10
Regulation of localization of FOXO transcription factors	10	1.96e-02	-0.426000	7.34e-02
Viral mRNA Translation	81	3.64e-11	-0.426000	1.49e-09
SLC transporter disorders	53	8.31e-08	0.426000	1.72e-06
Prefoldin mediated transfer of substrate to CCT/TriC	25	2.37e-04	-0.425000	1.80e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	38	5.93e-06	-0.425000	8.54e-05
TNFs bind their physiological receptors	5	1.00e-01	-0.424000	2.44e-01
Cholesterol biosynthesis via lathosterol	7	5.24e-02	-0.424000	1.54e-01
Transcriptional regulation of pluripotent stem cells	8	3.82e-02	0.423000	1.22e-01
Glycosphingolipid catabolism	23	4.69e-04	0.422000	3.16e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression	5	1.03e-01	0.421000	2.47e-01
SRP-dependent cotranslational protein targeting to membrane	103	1.84e-13	-0.421000	2.02e-11
Activation of G protein gated Potassium channels	6	7.46e-02	-0.420000	1.99e-01
G beta:gamma signalling through BTK	6	7.46e-02	-0.420000	1.99e-01
G protein gated Potassium channels	6	7.46e-02	-0.420000	1.99e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	6	7.46e-02	-0.420000	1.99e-01
Inwardly rectifying K+ channels	6	7.46e-02	-0.420000	1.99e-01
Peroxisomal lipid metabolism	21	8.69e-04	0.420000	5.32e-03
Arachidonate metabolism	24	3.76e-04	0.420000	2.65e-03
Mitochondrial calcium ion transport	21	8.77e-04	0.420000	5.35e-03
Cholesterol biosynthesis	25	2.87e-04	-0.419000	2.11e-03
SMAC (DIABLO) binds to IAPs	7	5.54e-02	-0.418000	1.59e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	5.54e-02	-0.418000	1.59e-01
SMAC, XIAP-regulated apoptotic response	7	5.54e-02	-0.418000	1.59e-01
Deadenylation of mRNA	25	3.15e-04	-0.417000	2.28e-03
NPAS4 regulates expression of target genes	8	4.14e-02	-0.417000	1.30e-01
CDK-mediated phosphorylation and removal of Cdc6	45	1.46e-06	-0.416000	2.33e-05
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	27	1.94e-04	-0.415000	1.54e-03
Pregnenolone biosynthesis	7	5.76e-02	0.415000	1.63e-01
IL-6-type cytokine receptor ligand interactions	6	7.99e-02	0.413000	2.07e-01
RHOT1 GTPase cycle	5	1.10e-01	0.413000	2.61e-01
Autodegradation of Cdh1 by Cdh1:APC/C	44	2.24e-06	-0.413000	3.51e-05
Synthesis of PIPs at the ER membrane	5	1.11e-01	-0.412000	2.62e-01
Activation of gene expression by SREBF (SREBP)	32	5.65e-05	-0.412000	5.55e-04
Diseases of carbohydrate metabolism	19	1.95e-03	0.411000	1.09e-02
Translation initiation complex formation	57	8.74e-08	-0.410000	1.79e-06
Vif-mediated degradation of APOBEC3G	37	1.67e-05	-0.409000	2.11e-04
RIPK1-mediated regulated necrosis	22	9.47e-04	-0.407000	5.66e-03
Regulation of necroptotic cell death	22	9.47e-04	-0.407000	5.66e-03
Ribosomal scanning and start codon recognition	57	1.12e-07	-0.407000	2.26e-06
Cobalamin (Cbl) metabolism	7	6.25e-02	0.407000	1.74e-01
Glycolysis	60	5.57e-08	0.406000	1.21e-06
Miro GTPase Cycle	8	4.71e-02	0.406000	1.43e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	49	9.93e-07	-0.405000	1.66e-05
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	49	9.93e-07	-0.405000	1.66e-05
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	6	8.79e-02	-0.402000	2.23e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	1.20e-01	0.402000	2.78e-01
Somitogenesis	35	4.45e-05	-0.399000	4.60e-04
Defects in vitamin and cofactor metabolism	17	4.41e-03	0.399000	2.15e-02
G alpha (z) signalling events	23	9.46e-04	-0.399000	5.66e-03
Inositol phosphate metabolism	55	3.46e-07	0.398000	6.26e-06
Transcriptional regulation by small RNAs	51	9.23e-07	0.398000	1.57e-05
tRNA Aminoacylation	42	8.44e-06	0.398000	1.15e-04
Regulation of PTEN stability and activity	46	3.27e-06	-0.397000	4.91e-05
Cargo trafficking to the periciliary membrane	43	6.87e-06	-0.397000	9.66e-05
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	2.16e-08	0.396000	5.21e-07
Regulation of expression of SLITs and ROBOs	136	2.27e-15	-0.395000	3.33e-13
Regulation of cholesterol biosynthesis by SREBP (SREBF)	43	7.64e-06	-0.395000	1.06e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	103	5.21e-12	-0.395000	2.86e-10
Nonsense-Mediated Decay (NMD)	103	5.21e-12	-0.395000	2.86e-10
CS/DS degradation	10	3.10e-02	0.394000	1.05e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	5	1.28e-01	-0.393000	2.92e-01
Vpu mediated degradation of CD4	33	9.49e-05	-0.393000	8.48e-04
Stabilization of p53	35	6.14e-05	-0.392000	5.93e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	2.72e-07	-0.391000	5.08e-06
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	8	5.61e-02	0.390000	1.59e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	8	5.61e-02	0.390000	1.59e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	8	5.61e-02	0.390000	1.59e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	8	5.61e-02	0.390000	1.59e-01
Impaired BRCA2 binding to PALB2	8	5.61e-02	0.390000	1.59e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	8	5.61e-02	0.390000	1.59e-01
Glucose metabolism	65	5.85e-08	0.390000	1.25e-06
NIK–>noncanonical NF-kB signaling	40	2.07e-05	-0.390000	2.49e-04
Regulation of ornithine decarboxylase (ODC)	32	1.53e-04	-0.387000	1.28e-03
Cytosolic iron-sulfur cluster assembly	10	3.44e-02	-0.387000	1.13e-01
CDH11 homotypic and heterotypic interactions	5	1.35e-01	0.386000	3.03e-01
Arachidonate production from DAG	5	1.35e-01	-0.386000	3.03e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	41	2.08e-05	-0.385000	2.49e-04
G beta:gamma signalling through PLC beta	7	7.87e-02	-0.384000	2.05e-01
Presynaptic function of Kainate receptors	7	7.87e-02	-0.384000	2.05e-01
Degradation of AXIN	34	1.09e-04	-0.384000	9.51e-04
Autodegradation of the E3 ubiquitin ligase COP1	34	1.13e-04	-0.383000	9.79e-04
The role of GTSE1 in G2/M progression after G2 checkpoint	52	1.89e-06	-0.383000	2.99e-05
Activated NOTCH1 Transmits Signal to the Nucleus	20	3.12e-03	-0.382000	1.65e-02
Degradation of CRY and PER proteins	37	6.06e-05	-0.381000	5.91e-04
Mitochondrial protein degradation	95	1.54e-10	0.381000	5.37e-09
GABA receptor activation	14	1.37e-02	-0.381000	5.53e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	36	7.80e-05	-0.381000	7.18e-04
APC-Cdc20 mediated degradation of Nek2A	17	6.59e-03	-0.381000	3.05e-02
Activation of RAC1 downstream of NMDARs	5	1.40e-01	-0.381000	3.12e-01
SCF(Skp2)-mediated degradation of p27/p21	39	3.98e-05	-0.381000	4.19e-04
SCF-beta-TrCP mediated degradation of Emi1	35	1.05e-04	-0.379000	9.18e-04
SARS-CoV-1 modulates host translation machinery	36	8.38e-05	-0.379000	7.63e-04
Degradation of DVL	38	5.35e-05	-0.379000	5.34e-04
Heme degradation	8	6.36e-02	0.379000	1.76e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	37	6.86e-05	-0.379000	6.52e-04
Carboxyterminal post-translational modifications of tubulin	16	9.05e-03	-0.377000	4.00e-02
Cyclin A:Cdk2-associated events at S phase entry	51	3.51e-06	-0.376000	5.18e-05
Cyclin E associated events during G1/S transition	51	3.51e-06	-0.376000	5.18e-05
MyD88 deficiency (TLR2/4)	8	6.56e-02	0.376000	1.80e-01
Negative regulation of NOTCH4 signaling	38	6.57e-05	-0.375000	6.28e-04
APC/C:Cdc20 mediated degradation of Securin	46	1.17e-05	-0.374000	1.54e-04
Response of Mtb to phagocytosis	17	7.64e-03	-0.374000	3.47e-02
Gap junction trafficking and regulation	28	6.25e-04	-0.374000	4.02e-03
CREB phosphorylation	5	1.48e-01	-0.374000	3.25e-01
Alpha-protein kinase 1 signaling pathway	5	1.48e-01	-0.373000	3.26e-01
IRAK2 mediated activation of TAK1 complex	5	1.48e-01	-0.373000	3.26e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	13	2.01e-02	-0.373000	7.48e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	63	3.37e-07	-0.372000	6.17e-06
Ion transport by P-type ATPases	33	2.19e-04	-0.372000	1.69e-03
ADP signalling through P2Y purinoceptor 12	9	5.39e-02	-0.371000	1.57e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	16	1.02e-02	-0.371000	4.44e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	16	1.02e-02	-0.371000	4.44e-02
PI3K events in ERBB2 signaling	7	8.94e-02	0.371000	2.25e-01
Regulation of Apoptosis	36	1.24e-04	-0.370000	1.06e-03
Dectin-1 mediated noncanonical NF-kB signaling	41	4.24e-05	-0.370000	4.43e-04
Antimicrobial peptides	14	1.67e-02	0.370000	6.44e-02
Signalling to ERKs	22	2.74e-03	-0.369000	1.46e-02
Cellular response to hypoxia	47	1.23e-05	-0.369000	1.59e-04
Degradation of GLI1 by the proteasome	40	5.60e-05	-0.369000	5.52e-04
SPOP-mediated proteasomal degradation of PD-L1(CD274)	41	4.63e-05	-0.368000	4.73e-04
TICAM1, RIP1-mediated IKK complex recruitment	12	2.76e-02	-0.367000	9.59e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	51	6.20e-06	-0.366000	8.79e-05
Activation of GABAB receptors	13	2.23e-02	-0.366000	8.05e-02
GABA B receptor activation	13	2.23e-02	-0.366000	8.05e-02
Hyaluronan degradation	9	5.75e-02	0.366000	1.63e-01
RHO GTPases Activate Rhotekin and Rhophilins	6	1.21e-01	-0.365000	2.81e-01
p53-Dependent G1 DNA Damage Response	37	1.23e-04	-0.365000	1.06e-03
p53-Dependent G1/S DNA damage checkpoint	37	1.23e-04	-0.365000	1.06e-03
Gap junction trafficking	26	1.33e-03	-0.364000	7.65e-03
FCGR activation	9	5.88e-02	0.364000	1.65e-01
Post-chaperonin tubulin folding pathway	17	9.45e-03	-0.364000	4.13e-02
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	42	4.72e-05	-0.363000	4.76e-04
p53-Independent G1/S DNA Damage Checkpoint	42	4.72e-05	-0.363000	4.76e-04
Intrinsic Pathway of Fibrin Clot Formation	8	7.57e-02	0.363000	2.01e-01
Metabolism of polyamines	35	2.14e-04	-0.362000	1.68e-03
Pentose phosphate pathway	12	3.01e-02	0.362000	1.03e-01
Killing mechanisms	8	7.77e-02	-0.360000	2.04e-01
WNT5:FZD7-mediated leishmania damping	8	7.77e-02	-0.360000	2.04e-01
Interleukin-27 signaling	8	7.80e-02	0.360000	2.04e-01
Interleukin-35 Signalling	8	7.80e-02	0.360000	2.04e-01
Glycosphingolipid transport	7	9.92e-02	-0.360000	2.42e-01
Degradation of GLI2 by the proteasome	40	8.71e-05	-0.359000	7.88e-04
NOTCH4 Intracellular Domain Regulates Transcription	9	6.30e-02	-0.358000	1.75e-01
RHOT2 GTPase cycle	7	1.01e-01	0.358000	2.45e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	6	1.29e-01	-0.358000	2.94e-01
NFE2L2 regulating tumorigenic genes	7	1.01e-01	-0.358000	2.46e-01
Cross-presentation of soluble exogenous antigens (endosomes)	37	1.72e-04	-0.357000	1.39e-03
Regulation of APC/C activators between G1/S and early anaphase	54	5.78e-06	-0.357000	8.39e-05
TNFR2 non-canonical NF-kB pathway	51	1.05e-05	-0.357000	1.41e-04
Signaling by NOTCH4	55	4.82e-06	-0.357000	7.06e-05
rRNA processing in the mitochondrion	28	1.09e-03	0.357000	6.42e-03
GLI3 is processed to GLI3R by the proteasome	41	7.85e-05	-0.357000	7.18e-04
Switching of origins to a post-replicative state	59	2.28e-06	-0.356000	3.54e-05
Neurotoxicity of clostridium toxins	6	1.32e-01	0.356000	2.98e-01
LDL clearance	15	1.73e-02	-0.355000	6.61e-02
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	12	3.32e-02	-0.355000	1.10e-01
Regulation of RAS by GAPs	46	3.23e-05	-0.355000	3.57e-04
Orc1 removal from chromatin	47	2.67e-05	-0.355000	3.10e-04
RUNX3 regulates YAP1-mediated transcription	5	1.71e-01	0.354000	3.56e-01
Kinesins	41	9.52e-05	-0.353000	8.48e-04
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	52	1.13e-05	-0.353000	1.50e-04
Adrenaline,noradrenaline inhibits insulin secretion	11	4.34e-02	-0.352000	1.35e-01
Paracetamol ADME	11	4.37e-02	0.351000	1.36e-01
Formation of the ureteric bud	5	1.79e-01	0.347000	3.68e-01
Attachment and Entry 9694614	13	3.11e-02	-0.345000	1.05e-01
Formation of paraxial mesoderm	39	2.21e-04	-0.342000	1.69e-03
Degradation of cysteine and homocysteine	10	6.11e-02	0.342000	1.70e-01
Activation of NF-kappaB in B cells	45	7.38e-05	-0.342000	6.89e-04
RHOV GTPase cycle	30	1.23e-03	-0.341000	7.14e-03
Basigin interactions	17	1.51e-02	-0.341000	5.92e-02
Cell-extracellular matrix interactions	15	2.27e-02	-0.340000	8.16e-02
Assembly of the pre-replicative complex	64	2.72e-06	-0.340000	4.15e-05
Effects of PIP2 hydrolysis	16	1.88e-02	-0.340000	7.11e-02
Generation of second messenger molecules	10	6.35e-02	-0.339000	1.76e-01
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	38	3.06e-04	-0.339000	2.23e-03
Hedgehog ‘on’ state	50	3.54e-05	-0.339000	3.82e-04
Blood group systems biosynthesis	5	1.91e-01	0.338000	3.88e-01
Metabolism of folate and pterines	13	3.51e-02	0.338000	1.15e-01
Signaling by ROBO receptors	174	2.18e-14	-0.338000	2.56e-12
Antigen processing: Ub, ATP-independent proteasomal degradation	19	1.09e-02	-0.338000	4.65e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	50	3.92e-05	-0.337000	4.15e-04
RHOU GTPase cycle	33	8.30e-04	-0.337000	5.10e-03
Transport of Mature Transcript to Cytoplasm	75	6.13e-07	0.334000	1.07e-05
Interconversion of nucleotide di- and triphosphates	25	3.94e-03	0.333000	1.98e-02
Formation of definitive endoderm	8	1.03e-01	0.333000	2.47e-01
ROS and RNS production in phagocytes	16	2.11e-02	-0.333000	7.78e-02
DNA Replication Pre-Initiation	75	6.71e-07	-0.333000	1.16e-05
Detoxification of Reactive Oxygen Species	24	4.83e-03	0.333000	2.32e-02
Insulin processing	18	1.49e-02	-0.332000	5.85e-02
Ethanol oxidation	5	2.00e-01	0.331000	3.96e-01
Regulation of RUNX3 expression and activity	39	3.58e-04	-0.331000	2.54e-03
Matriglycan biosynthesis on DAG1	9	8.59e-02	0.331000	2.19e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	23	6.20e-03	-0.330000	2.90e-02
PD-L1(CD274) glycosylation and translocation to plasma membrane	14	3.31e-02	0.329000	1.10e-01
Tryptophan catabolism	5	2.03e-01	-0.329000	4.01e-01
Diseases associated with N-glycosylation of proteins	20	1.13e-02	0.328000	4.77e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	14	3.40e-02	-0.327000	1.12e-01
NOD1/2 Signaling Pathway	22	8.08e-03	-0.326000	3.64e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	20	1.16e-02	-0.326000	4.88e-02
ALK mutants bind TKIs	10	7.42e-02	-0.326000	1.99e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	1.67e-01	-0.326000	3.52e-01
Attachment of GPI anchor to uPAR	7	1.37e-01	-0.325000	3.06e-01
IRAK4 deficiency (TLR2/4)	9	9.21e-02	0.324000	2.31e-01
Hyaluronan metabolism	11	6.27e-02	0.324000	1.74e-01
IKK complex recruitment mediated by RIP1	13	4.39e-02	-0.323000	1.36e-01
Hh mutants abrogate ligand secretion	38	6.06e-04	-0.322000	3.93e-03
Hh mutants are degraded by ERAD	38	6.06e-04	-0.322000	3.93e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	13	4.60e-02	-0.320000	1.41e-01
Adenylate cyclase inhibitory pathway	7	1.43e-01	-0.319000	3.18e-01
Hedgehog ligand biogenesis	40	4.91e-04	-0.319000	3.27e-03
APC/C-mediated degradation of cell cycle proteins	58	2.81e-05	-0.319000	3.19e-04
Regulation of mitotic cell cycle	58	2.81e-05	-0.319000	3.19e-04
Caspase activation via Dependence Receptors in the absence of ligand	7	1.45e-01	-0.318000	3.20e-01
SUMOylation of DNA damage response and repair proteins	61	1.79e-05	0.318000	2.23e-04
Cellular response to starvation	121	1.75e-09	-0.318000	5.21e-08
PECAM1 interactions	8	1.20e-01	-0.318000	2.78e-01
Regulation of RUNX2 expression and activity	42	3.81e-04	-0.317000	2.66e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus	15	3.42e-02	-0.316000	1.12e-01
Selenoamino acid metabolism	102	4.14e-08	-0.315000	9.25e-07
Proteasome assembly	48	1.61e-04	-0.315000	1.32e-03
HDL assembly	6	1.81e-01	0.315000	3.71e-01
Surfactant metabolism	5	2.23e-01	-0.315000	4.22e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	6	1.83e-01	-0.314000	3.74e-01
MET activates RAP1 and RAC1	8	1.25e-01	-0.313000	2.87e-01
Cytochrome c-mediated apoptotic response	13	5.14e-02	-0.312000	1.52e-01
G1/S DNA Damage Checkpoints	46	2.79e-04	-0.310000	2.06e-03
Synthesis of DNA	82	1.39e-06	-0.309000	2.27e-05
Hedgehog ‘off’ state	70	8.46e-06	-0.309000	1.15e-04
SARS-CoV-2 modulates host translation machinery	48	2.29e-04	-0.308000	1.75e-03
TNFR1-induced NF-kappa-B signaling pathway	20	1.74e-02	-0.307000	6.64e-02
Expression of BMAL (ARNTL), CLOCK, and NPAS2	12	6.54e-02	-0.307000	1.80e-01
Regulation of HSF1-mediated heat shock response	70	9.97e-06	0.306000	1.35e-04
Suppression of apoptosis	6	1.95e-01	-0.306000	3.91e-01
Membrane binding and targetting of GAG proteins	10	9.42e-02	0.306000	2.34e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	10	9.42e-02	0.306000	2.34e-01
Biotin transport and metabolism	9	1.12e-01	0.306000	2.65e-01
G-protein activation	8	1.35e-01	-0.305000	3.03e-01
Infection with Mycobacterium tuberculosis	19	2.16e-02	-0.305000	7.89e-02
Defective CFTR causes cystic fibrosis	42	6.57e-04	-0.304000	4.20e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	28	5.38e-03	-0.304000	2.56e-02
Assembly and cell surface presentation of NMDA receptors	23	1.16e-02	-0.304000	4.88e-02
Glucagon signaling in metabolic regulation	16	3.55e-02	-0.304000	1.16e-01
tRNA processing	99	1.96e-07	0.304000	3.83e-06
Defects in cobalamin (B12) metabolism	10	9.71e-02	0.303000	2.38e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	15	4.25e-02	-0.303000	1.33e-01
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	49	2.53e-04	-0.303000	1.88e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	8.29e-02	-0.302000	2.14e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	6	2.02e-01	-0.301000	3.98e-01
Diseases of mitotic cell cycle	21	1.71e-02	-0.301000	6.55e-02
Interleukin-1 signaling	71	1.30e-05	-0.300000	1.67e-04
G alpha (12/13) signalling events	39	1.21e-03	-0.300000	7.06e-03
RHO GTPases activate KTN1	10	1.01e-01	-0.300000	2.45e-01
GPER1 signaling	24	1.11e-02	-0.300000	4.73e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	20	2.10e-02	-0.298000	7.78e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	15	4.57e-02	0.298000	1.40e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	6	2.08e-01	-0.297000	4.05e-01
Protein localization	136	2.76e-09	0.297000	7.70e-08
TICAM1-dependent activation of IRF3/IRF7	6	2.09e-01	-0.296000	4.06e-01
Maturation of spike protein 9683686	5	2.53e-01	0.295000	4.60e-01
MAPK6/MAPK4 signaling	59	9.10e-05	-0.295000	8.20e-04
Rap1 signalling	8	1.49e-01	-0.295000	3.26e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	68	2.72e-05	-0.295000	3.14e-04
Activation of BAD and translocation to mitochondria	15	4.86e-02	-0.294000	1.46e-01
Gene Silencing by RNA	65	4.32e-05	0.294000	4.49e-04
Regulation of CDH1 Function	52	2.52e-04	-0.294000	1.88e-03
Uptake and function of anthrax toxins	10	1.08e-01	-0.294000	2.57e-01
Endosomal/Vacuolar pathway	11	9.20e-02	-0.294000	2.31e-01
Glycosphingolipid biosynthesis	8	1.51e-01	-0.293000	3.28e-01
Heme biosynthesis	12	7.89e-02	0.293000	2.05e-01
Downstream signaling events of B Cell Receptor (BCR)	54	2.08e-04	-0.292000	1.64e-03
Glutathione synthesis and recycling	8	1.53e-01	0.292000	3.32e-01
Long-term potentiation	11	9.53e-02	0.291000	2.36e-01
Metabolism of porphyrins	18	3.32e-02	0.290000	1.10e-01
Activation of ATR in response to replication stress	22	1.87e-02	-0.290000	7.11e-02
Fatty acid metabolism	108	2.24e-07	0.290000	4.32e-06
Nectin/Necl trans heterodimerization	5	2.63e-01	0.289000	4.71e-01
Resolution of D-Loop Structures	9	1.34e-01	0.288000	3.02e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	9	1.34e-01	0.288000	3.02e-01
S Phase	107	3.03e-07	-0.288000	5.60e-06
Respiratory syncytial virus (RSV) attachment and entry	17	4.08e-02	-0.287000	1.29e-01
Carnitine shuttle	8	1.62e-01	-0.286000	3.45e-01
Small interfering RNA (siRNA) biogenesis	8	1.63e-01	-0.285000	3.48e-01
Molecules associated with elastic fibres	19	3.20e-02	0.284000	1.07e-01
Golgi Associated Vesicle Biogenesis	50	5.30e-04	-0.284000	3.48e-03
GRB2 events in ERBB2 signaling	9	1.41e-01	0.283000	3.13e-01
Degradation of CDH1	47	7.90e-04	-0.283000	4.87e-03
IkBA variant leads to EDA-ID	6	2.30e-01	-0.283000	4.30e-01
BMAL1:CLOCK,NPAS2 activates circadian expression	10	1.22e-01	-0.283000	2.81e-01
Signaling by NOTCH2	19	3.34e-02	-0.282000	1.10e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	9	1.45e-01	-0.281000	3.20e-01
activated TAK1 mediates p38 MAPK activation	14	6.92e-02	-0.281000	1.88e-01
Signal transduction by L1	20	2.99e-02	-0.281000	1.03e-01
Purine ribonucleoside monophosphate biosynthesis	10	1.27e-01	0.279000	2.90e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	21	2.70e-02	-0.279000	9.45e-02
Aquaporin-mediated transport	18	4.07e-02	-0.279000	1.29e-01
Vasopressin regulates renal water homeostasis via Aquaporins	18	4.07e-02	-0.279000	1.29e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	1.83e-02	-0.279000	6.96e-02
M-decay: degradation of maternal mRNAs by maternally stored factors	31	7.46e-03	-0.278000	3.40e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	12	9.60e-02	-0.278000	2.37e-01
Major pathway of rRNA processing in the nucleolus and cytosol	164	1.13e-09	-0.277000	3.49e-08
RUNX3 regulates NOTCH signaling	8	1.75e-01	-0.277000	3.63e-01
Cytoprotection by HMOX1	37	3.69e-03	-0.276000	1.89e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	8	1.76e-01	-0.276000	3.64e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	8	1.76e-01	-0.276000	3.64e-01
Defective RIPK1-mediated regulated necrosis	6	2.44e-01	-0.274000	4.47e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	15	6.62e-02	-0.274000	1.81e-01
APC/C:Cdc20 mediated degradation of Cyclin B	16	5.80e-02	-0.274000	1.63e-01
WNT ligand biogenesis and trafficking	11	1.16e-01	-0.273000	2.72e-01
Deadenylation-dependent mRNA decay	56	4.25e-04	-0.273000	2.92e-03
Mitotic Prophase	77	3.81e-05	0.272000	4.05e-04
BBSome-mediated cargo-targeting to cilium	11	1.18e-01	-0.272000	2.76e-01
Co-inhibition by CTLA4	16	5.99e-02	-0.272000	1.67e-01
RHOF GTPase cycle	38	3.79e-03	-0.272000	1.93e-02
Activation of NMDA receptors and postsynaptic events	55	5.04e-04	-0.272000	3.32e-03
Asymmetric localization of PCP proteins	42	2.36e-03	-0.272000	1.29e-02
Binding and Uptake of Ligands by Scavenger Receptors	29	1.18e-02	0.270000	4.91e-02
Chaperonin-mediated protein folding	52	7.60e-04	-0.270000	4.71e-03
TCR signaling	70	9.56e-05	-0.270000	8.48e-04
Neurotransmitter receptors and postsynaptic signal transmission	84	1.96e-05	-0.270000	2.40e-04
RUNX1 regulates transcription of genes involved in differentiation of HSCs	50	9.77e-04	-0.270000	5.82e-03
CLEC7A (Dectin-1) signaling	68	1.24e-04	-0.270000	1.06e-03
NFE2L2 regulating anti-oxidant/detoxification enzymes	13	9.27e-02	0.269000	2.32e-01
G1/S Transition	84	2.08e-05	-0.269000	2.49e-04
Ion channel transport	76	5.35e-05	-0.269000	5.34e-04
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	8	1.91e-01	-0.267000	3.88e-01
RHOB GTPase cycle	59	3.99e-04	-0.267000	2.77e-03
Downstream TCR signaling	58	4.59e-04	-0.267000	3.10e-03
Gluconeogenesis	15	7.42e-02	0.266000	1.99e-01
EPHB-mediated forward signaling	37	5.21e-03	-0.266000	2.48e-02
SHC-related events triggered by IGF1R	8	1.93e-01	-0.266000	3.89e-01
FCERI mediated NF-kB activation	56	6.23e-04	-0.265000	4.02e-03
p75NTR recruits signalling complexes	9	1.69e-01	-0.265000	3.54e-01
ABC transporter disorders	51	1.10e-03	-0.265000	6.46e-03
WNT5A-dependent internalization of FZD4	13	9.89e-02	-0.264000	2.41e-01
Antigen processing-Cross presentation	76	7.09e-05	-0.264000	6.66e-04
ER-Phagosome pathway	68	1.70e-04	-0.264000	1.38e-03
ADP signalling through P2Y purinoceptor 1	12	1.13e-01	-0.264000	2.66e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	3.07e-01	0.264000	5.17e-01
ADORA2B mediated anti-inflammatory cytokines production	21	3.67e-02	-0.263000	1.18e-01
Role of second messengers in netrin-1 signaling	5	3.08e-01	0.263000	5.18e-01
Circadian clock	65	2.53e-04	-0.263000	1.88e-03
RAC1 GTPase cycle	124	4.82e-07	-0.263000	8.48e-06
Activation of the pre-replicative complex	22	3.30e-02	-0.263000	1.10e-01
Cristae formation	31	1.15e-02	0.263000	4.86e-02
Reduction of cytosolic Ca++ levels	9	1.73e-01	-0.262000	3.60e-01
HCMV Early Events	70	1.54e-04	0.262000	1.28e-03
Aflatoxin activation and detoxification	7	2.30e-01	0.262000	4.30e-01
Interleukin-1 family signaling	86	2.79e-05	-0.262000	3.19e-04
PP2A-mediated dephosphorylation of key metabolic factors	5	3.10e-01	0.262000	5.21e-01
Lysosome Vesicle Biogenesis	29	1.48e-02	-0.262000	5.83e-02
Trafficking of GluR2-containing AMPA receptors	9	1.74e-01	-0.262000	3.62e-01
trans-Golgi Network Vesicle Budding	64	3.13e-04	-0.261000	2.27e-03
Aggrephagy	28	1.69e-02	-0.261000	6.51e-02
Maturation of nucleoprotein 9683610	6	2.70e-01	-0.260000	4.77e-01
rRNA processing in the nucleus and cytosol	174	3.99e-09	-0.260000	1.10e-07
p75 NTR receptor-mediated signalling	57	6.97e-04	-0.260000	4.36e-03
Fanconi Anemia Pathway	14	9.33e-02	-0.259000	2.33e-01
Elevation of cytosolic Ca2+ levels	8	2.06e-01	0.258000	4.03e-01
DAG1 glycosylations	14	9.44e-02	0.258000	2.34e-01
Cellular response to heat stress	84	4.53e-05	0.258000	4.65e-04
Loss of Function of SMAD2/3 in Cancer	7	2.37e-01	0.258000	4.40e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	33	1.05e-02	-0.258000	4.54e-02
Regulation of NFE2L2 gene expression	5	3.20e-01	-0.257000	5.28e-01
FOXO-mediated transcription of cell cycle genes	8	2.10e-01	0.256000	4.07e-01
Recycling pathway of L1	37	7.38e-03	-0.255000	3.38e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	1.28e-01	-0.254000	2.92e-01
TYSND1 cleaves peroxisomal proteins	7	2.45e-01	0.254000	4.49e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	9	1.89e-01	0.253000	3.84e-01
Metabolism of steroid hormones	11	1.46e-01	0.253000	3.23e-01
Maturation of nucleoprotein 9694631	10	1.66e-01	-0.253000	3.51e-01
p38MAPK events	9	1.89e-01	-0.253000	3.85e-01
Pyruvate metabolism	33	1.25e-02	0.251000	5.18e-02
Axon guidance	370	2.61e-16	-0.251000	6.55e-14
Post NMDA receptor activation events	50	2.15e-03	-0.251000	1.19e-02
Regulation of CDH11 function	8	2.19e-01	0.251000	4.17e-01
Cleavage of the damaged pyrimidine	10	1.69e-01	0.251000	3.54e-01
Depyrimidination	10	1.69e-01	0.251000	3.54e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	10	1.69e-01	0.251000	3.54e-01
TP53 Regulates Metabolic Genes	69	3.35e-04	-0.250000	2.40e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	1.19e-01	-0.250000	2.76e-01
Calnexin/calreticulin cycle	22	4.27e-02	0.250000	1.33e-01
Serine metabolism	8	2.21e-01	-0.250000	4.20e-01
G2/M Checkpoints	87	6.30e-05	-0.249000	6.05e-04
Formation of ATP by chemiosmotic coupling	18	6.84e-02	0.248000	1.86e-01
Regulated Necrosis	40	6.66e-03	-0.248000	3.08e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	8	2.25e-01	-0.248000	4.24e-01
Apoptotic cleavage of cellular proteins	33	1.41e-02	-0.247000	5.65e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	35	1.18e-02	-0.246000	4.91e-02
ABC-family proteins mediated transport	64	6.89e-04	-0.246000	4.34e-03
COPI-dependent Golgi-to-ER retrograde traffic	79	1.67e-04	-0.246000	1.37e-03
Plasma lipoprotein clearance	21	5.15e-02	-0.246000	1.52e-01
Mitochondrial unfolded protein response (UPRmt)	14	1.12e-01	0.245000	2.65e-01
Antigen processing: Ubiquitination & Proteasome degradation	165	6.70e-08	-0.245000	1.42e-06
FLT3 Signaling	23	4.21e-02	-0.245000	1.32e-01
Programmed Cell Death	157	1.44e-07	-0.245000	2.88e-06
Sphingolipid catabolism	6	3.01e-01	-0.244000	5.08e-01
Nervous system development	384	7.07e-16	-0.243000	1.55e-13
C-type lectin receptors (CLRs)	82	1.46e-04	-0.243000	1.23e-03
UCH proteinases	58	1.40e-03	-0.243000	8.02e-03
Phosphorylation of the APC/C	15	1.03e-01	-0.243000	2.48e-01
ChREBP activates metabolic gene expression	6	3.03e-01	-0.243000	5.11e-01
Acetylcholine Neurotransmitter Release Cycle	9	2.09e-01	0.242000	4.06e-01
Glutathione conjugation	19	6.86e-02	0.242000	1.86e-01
DNA replication initiation	7	2.69e-01	-0.241000	4.77e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	2.38e-01	0.241000	4.40e-01
PCP/CE pathway	67	6.64e-04	-0.241000	4.21e-03
SARS-CoV-1-host interactions	83	1.54e-04	-0.241000	1.28e-03
Activation of SMO	7	2.70e-01	-0.241000	4.77e-01
Condensation of Prometaphase Chromosomes	11	1.68e-01	-0.240000	3.53e-01
tRNA modification in the nucleus and cytosol	31	2.08e-02	0.240000	7.71e-02
Downregulation of ERBB2:ERBB3 signaling	7	2.71e-01	-0.240000	4.78e-01
G alpha (s) signalling events	37	1.20e-02	-0.239000	4.97e-02
FCGR3A-mediated phagocytosis	49	4.06e-03	-0.238000	2.00e-02
Leishmania phagocytosis	49	4.06e-03	-0.238000	2.00e-02
Parasite infection	49	4.06e-03	-0.238000	2.00e-02
TNF signaling	37	1.25e-02	-0.237000	5.18e-02
Glycosphingolipid metabolism	31	2.24e-02	0.237000	8.09e-02
Laminin interactions	23	4.94e-02	-0.237000	1.48e-01
Regulation of actin dynamics for phagocytic cup formation	50	3.85e-03	-0.237000	1.95e-02
Peptide hormone metabolism	35	1.57e-02	-0.236000	6.11e-02
CDC42 GTPase cycle	106	2.89e-05	-0.236000	3.26e-04
PCNA-Dependent Long Patch Base Excision Repair	18	8.34e-02	-0.236000	2.15e-01
Ub-specific processing proteases	111	1.93e-05	-0.236000	2.39e-04
RHOQ GTPase cycle	51	3.68e-03	-0.236000	1.89e-02
The canonical retinoid cycle in rods (twilight vision)	6	3.18e-01	-0.235000	5.26e-01
Interleukin-15 signaling	7	2.81e-01	-0.235000	4.88e-01
Regulation of TNFR1 signaling	31	2.37e-02	-0.235000	8.47e-02
NRAGE signals death through JNK	31	2.39e-02	-0.235000	8.48e-02
Apoptosis	136	2.59e-06	-0.235000	3.99e-05
Dual Incision in GG-NER	31	2.40e-02	-0.235000	8.52e-02
Protein folding	58	2.06e-03	-0.234000	1.15e-02
Formation of apoptosome	11	1.78e-01	-0.234000	3.67e-01
Regulation of the apoptosome activity	11	1.78e-01	-0.234000	3.67e-01
Signaling by Hedgehog	88	1.56e-04	-0.234000	1.29e-03
Death Receptor Signaling	93	1.02e-04	-0.234000	8.99e-04
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	22	5.80e-02	-0.234000	1.63e-01
Sensing of DNA Double Strand Breaks	5	3.66e-01	0.233000	5.77e-01
Regulation of pyruvate metabolism	23	5.28e-02	0.233000	1.54e-01
PKA activation in glucagon signalling	10	2.01e-01	-0.233000	3.98e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	13	1.47e-01	-0.232000	3.24e-01
Regulation of gene expression by Hypoxia-inducible Factor	5	3.69e-01	-0.232000	5.79e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	1.64e-01	-0.232000	3.49e-01
Gastrulation	50	4.79e-03	-0.231000	2.31e-02
Thrombin signalling through proteinase activated receptors (PARs)	17	9.97e-02	-0.231000	2.43e-01
Mitotic G1 phase and G1/S transition	93	1.32e-04	-0.230000	1.11e-03
Protein ubiquitination	55	3.27e-03	-0.230000	1.71e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	7	2.94e-01	-0.229000	5.02e-01
CD28 dependent Vav1 pathway	6	3.31e-01	-0.229000	5.40e-01
Signaling by high-kinase activity BRAF mutants	30	3.05e-02	-0.229000	1.04e-01
Class I MHC mediated antigen processing & presentation	224	5.47e-09	-0.228000	1.43e-07
Transcriptional regulation by RUNX2	70	1.01e-03	-0.228000	5.97e-03
RHOC GTPase cycle	67	1.29e-03	-0.228000	7.46e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation	10	2.12e-01	-0.228000	4.09e-01
Synthesis of UDP-N-acetyl-glucosamine	7	2.98e-01	-0.227000	5.07e-01
NOTCH3 Intracellular Domain Regulates Transcription	9	2.39e-01	-0.227000	4.41e-01
Formation of Fibrin Clot (Clotting Cascade)	17	1.06e-01	0.226000	2.54e-01
L1CAM interactions	80	4.96e-04	-0.226000	3.29e-03
Degradation of beta-catenin by the destruction complex	55	3.91e-03	-0.225000	1.97e-02
RHO GTPases activate IQGAPs	25	5.13e-02	-0.225000	1.52e-01
Lagging Strand Synthesis	18	9.86e-02	-0.225000	2.41e-01
NOTCH2 intracellular domain regulates transcription	5	3.86e-01	-0.224000	5.96e-01
p75NTR signals via NF-kB	11	1.99e-01	-0.224000	3.95e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	19	9.26e-02	-0.223000	2.32e-01
Phase II - Conjugation of compounds	39	1.63e-02	0.223000	6.32e-02
Peroxisomal protein import	43	1.18e-02	0.222000	4.91e-02
Germ layer formation at gastrulation	5	3.89e-01	0.222000	5.99e-01
MAP kinase activation	41	1.40e-02	-0.222000	5.64e-02
HCMV Infection	92	2.45e-04	0.222000	1.85e-03
CD163 mediating an anti-inflammatory response	6	3.47e-01	-0.222000	5.55e-01
Unblocking of NMDA receptors, glutamate binding and activation	8	2.78e-01	0.222000	4.85e-01
Senescence-Associated Secretory Phenotype (SASP)	36	2.17e-02	-0.221000	7.89e-02
Mismatch Repair	13	1.67e-01	-0.221000	3.53e-01
Caspase activation via extrinsic apoptotic signalling pathway	16	1.26e-01	-0.221000	2.89e-01
Chromatin modifications during the maternal to zygotic transition (MZT)	8	2.80e-01	0.221000	4.86e-01
Defective B4GALT7 causes EDS, progeroid type	13	1.69e-01	-0.221000	3.54e-01
RHO GTPases Activate NADPH Oxidases	14	1.54e-01	-0.220000	3.33e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	41	1.48e-02	-0.220000	5.84e-02
TGFBR3 PTM regulation	9	2.53e-01	-0.220000	4.60e-01
COPI-mediated anterograde transport	85	4.78e-04	-0.220000	3.20e-03
PI Metabolism	57	4.25e-03	-0.219000	2.07e-02
RHOA GTPase cycle	110	7.59e-05	-0.219000	7.03e-04
Clathrin-mediated endocytosis	107	9.72e-05	-0.219000	8.58e-04
Cell death signalling via NRAGE, NRIF and NADE	43	1.32e-02	-0.219000	5.39e-02
Interleukin-20 family signaling	9	2.56e-01	0.219000	4.65e-01
Fibronectin matrix formation	12	1.92e-01	-0.218000	3.89e-01
Association of TriC/CCT with target proteins during biosynthesis	23	7.12e-02	-0.218000	1.92e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	1.32e-01	-0.217000	2.99e-01
Processive synthesis on the lagging strand	13	1.75e-01	-0.217000	3.63e-01
Fc epsilon receptor (FCERI) signaling	91	3.61e-04	-0.217000	2.56e-03
Uptake and function of diphtheria toxin	6	3.57e-01	-0.217000	5.68e-01
Receptor-type tyrosine-protein phosphatases	9	2.60e-01	0.217000	4.69e-01
Signalling to RAS	12	1.95e-01	-0.216000	3.91e-01
Recognition of DNA damage by PCNA-containing replication complex	23	7.42e-02	-0.215000	1.99e-01
Metabolism of carbohydrates and carbohydrate derivatives	189	4.07e-07	0.215000	7.29e-06
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	19	1.05e-01	-0.215000	2.51e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	2.18e-01	0.215000	4.16e-01
alpha-linolenic acid (ALA) metabolism	11	2.18e-01	0.215000	4.16e-01
Polymerase switching on the C-strand of the telomere	20	9.67e-02	-0.215000	2.38e-01
Signaling by PDGFR in disease	18	1.15e-01	0.215000	2.70e-01
Telomere C-strand (Lagging Strand) Synthesis	26	5.93e-02	-0.214000	1.66e-01
Termination of O-glycan biosynthesis	6	3.65e-01	-0.214000	5.76e-01
Purine catabolism	11	2.20e-01	0.214000	4.18e-01
Signaling by PDGFRA extracellular domain mutants	12	2.01e-01	0.213000	3.98e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	2.01e-01	0.213000	3.98e-01
PRC2 methylates histones and DNA	11	2.22e-01	0.213000	4.20e-01
Positive Regulation of CDH1 Gene Transcription	6	3.67e-01	0.213000	5.77e-01
Intrinsic Pathway for Apoptosis	44	1.47e-02	-0.213000	5.83e-02
Platelet Adhesion to exposed collagen	7	3.31e-01	0.212000	5.40e-01
RNA Polymerase I Transcription Termination	22	8.54e-02	-0.212000	2.19e-01
Mitochondrial mRNA modification	23	7.87e-02	0.212000	2.05e-01
Beta-catenin independent WNT signaling	92	4.79e-04	-0.211000	3.20e-03
Activation of BH3-only proteins	22	8.67e-02	-0.211000	2.21e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	22	8.71e-02	-0.211000	2.22e-01
Cardiac conduction	37	2.72e-02	-0.210000	9.49e-02
PI3K/AKT activation	6	3.74e-01	0.210000	5.85e-01
Leishmania infection	105	2.20e-04	-0.210000	1.69e-03
Parasitic Infection Pathways	105	2.20e-04	-0.210000	1.69e-03
Fcgamma receptor (FCGR) dependent phagocytosis	69	2.69e-03	-0.209000	1.44e-02
Apoptotic execution phase	47	1.32e-02	-0.209000	5.39e-02
DNA Damage Recognition in GG-NER	29	5.15e-02	-0.209000	1.52e-01
RHO GTPase cycle	325	1.56e-10	-0.209000	5.37e-09
EPH-Ephrin signaling	70	2.56e-03	-0.209000	1.37e-02
Depolymerization of the Nuclear Lamina	13	1.93e-01	0.209000	3.89e-01
Early Phase of HIV Life Cycle	12	2.11e-01	-0.208000	4.08e-01
SUMO E3 ligases SUMOylate target proteins	107	2.16e-04	0.208000	1.69e-03
TNFR1-induced proapoptotic signaling	16	1.50e-01	-0.208000	3.28e-01
Common Pathway of Fibrin Clot Formation	11	2.33e-01	0.208000	4.35e-01
Protein hydroxylation	15	1.65e-01	-0.207000	3.50e-01
Transcriptional regulation by RUNX3	62	4.95e-03	-0.207000	2.38e-02
Base-Excision Repair, AP Site Formation	11	2.35e-01	0.207000	4.37e-01
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	11	2.35e-01	-0.207000	4.37e-01
Pyrimidine catabolism	6	3.81e-01	-0.207000	5.91e-01
Apoptotic factor-mediated response	18	1.30e-01	-0.206000	2.95e-01
Factors involved in megakaryocyte development and platelet production	98	4.41e-04	-0.206000	3.01e-03
Dissolution of Fibrin Clot	12	2.16e-01	-0.206000	4.15e-01
SUMOylation	112	1.80e-04	0.206000	1.44e-03
Retrograde transport at the Trans-Golgi-Network	44	1.85e-02	-0.206000	7.03e-02
RHOBTB2 GTPase cycle	22	9.55e-02	-0.206000	2.36e-01
RHOBTB GTPase Cycle	31	4.82e-02	-0.205000	1.46e-01
Global Genome Nucleotide Excision Repair (GG-NER)	66	4.05e-03	-0.205000	2.00e-02
E3 ubiquitin ligases ubiquitinate target proteins	37	3.12e-02	-0.205000	1.05e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	4.29e-01	0.204000	6.35e-01
Metabolism of nucleotides	69	3.49e-03	0.204000	1.81e-02
Serotonin Neurotransmitter Release Cycle	10	2.65e-01	0.204000	4.72e-01
Interleukin-17 signaling	42	2.28e-02	-0.203000	8.18e-02
Elastic fibre formation	24	8.58e-02	0.203000	2.19e-01
Signaling by Hippo	16	1.61e-01	-0.203000	3.44e-01
Growth hormone receptor signaling	12	2.25e-01	-0.203000	4.24e-01
Removal of the Flap Intermediate	12	2.25e-01	-0.203000	4.24e-01
DS-GAG biosynthesis	6	3.91e-01	-0.202000	6.01e-01
Assembly Of The HIV Virion	12	2.27e-01	0.201000	4.27e-01
Defective B3GAT3 causes JDSSDHD	13	2.09e-01	-0.201000	4.06e-01
Potassium Channels	14	1.93e-01	-0.201000	3.89e-01
Transmission across Chemical Synapses	117	1.85e-04	-0.201000	1.48e-03
MicroRNA (miRNA) biogenesis	20	1.21e-01	-0.201000	2.79e-01
InlB-mediated entry of Listeria monocytogenes into host cell	10	2.74e-01	-0.200000	4.80e-01
DAG1 core M3 glycosylations	6	3.97e-01	0.200000	6.05e-01
Diseases of Mismatch Repair (MMR)	5	4.39e-01	-0.200000	6.44e-01
ER Quality Control Compartment (ERQC)	17	1.54e-01	0.200000	3.34e-01
Glucuronidation	5	4.40e-01	0.200000	6.44e-01
Regulation of TLR by endogenous ligand	10	2.75e-01	0.199000	4.82e-01
SARS-CoV-1 Infection	114	2.50e-04	-0.199000	1.88e-03
STAT3 nuclear events downstream of ALK signaling	7	3.65e-01	0.198000	5.77e-01
AKT phosphorylates targets in the cytosol	11	2.57e-01	-0.198000	4.65e-01
Signaling by Retinoic Acid	24	9.45e-02	0.197000	2.34e-01
Transcriptional activation of mitochondrial biogenesis	34	4.70e-02	0.197000	1.43e-01
MAP2K and MAPK activation	32	5.39e-02	-0.197000	1.57e-01
DNA Replication	101	6.62e-04	-0.197000	4.21e-03
Ras activation upon Ca2+ influx through NMDA receptor	12	2.39e-01	0.197000	4.41e-01
Extension of Telomeres	38	3.64e-02	-0.196000	1.18e-01
DNA strand elongation	26	8.56e-02	-0.195000	2.19e-01
Oncogene Induced Senescence	17	1.64e-01	-0.195000	3.49e-01
Nuclear Envelope (NE) Reassembly	66	6.38e-03	0.195000	2.97e-02
Signaling by ERBB2	33	5.48e-02	-0.193000	1.58e-01
Signaling by NOTCH	117	3.22e-04	-0.193000	2.32e-03
Gap junction degradation	12	2.47e-01	-0.193000	4.50e-01
Leading Strand Synthesis	13	2.29e-01	-0.193000	4.30e-01
Polymerase switching	13	2.29e-01	-0.193000	4.30e-01
Membrane Trafficking	489	9.42e-13	-0.192000	7.53e-11
Nucleotide biosynthesis	13	2.31e-01	0.192000	4.31e-01
RAC3 GTPase cycle	73	4.74e-03	-0.192000	2.29e-02
Synaptic adhesion-like molecules	11	2.72e-01	0.191000	4.79e-01
TBC/RABGAPs	34	5.40e-02	-0.191000	1.57e-01
Class B/2 (Secretin family receptors)	21	1.32e-01	-0.190000	2.98e-01
Aerobic respiration and respiratory electron transport	224	1.25e-06	0.190000	2.07e-05
TICAM1,TRAF6-dependent induction of TAK1 complex	6	4.22e-01	-0.190000	6.30e-01
Methylation	10	3.00e-01	0.190000	5.08e-01
PTEN Regulation	96	1.39e-03	-0.190000	7.97e-03
Synthesis of GDP-mannose	5	4.63e-01	-0.189000	6.66e-01
GPVI-mediated activation cascade	20	1.44e-01	-0.189000	3.18e-01
Intra-Golgi traffic	36	5.03e-02	-0.189000	1.51e-01
Incretin synthesis, secretion, and inactivation	9	3.28e-01	-0.188000	5.35e-01
Signaling by EGFR	38	4.51e-02	-0.188000	1.39e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	4.25e-01	0.188000	6.31e-01
TGFBR1 KD Mutants in Cancer	6	4.25e-01	0.188000	6.31e-01
B-WICH complex positively regulates rRNA expression	28	8.54e-02	-0.188000	2.19e-01
Signaling by NODAL	11	2.81e-01	-0.188000	4.88e-01
Cardiogenesis	7	3.90e-01	0.188000	6.00e-01
Downregulation of ERBB2 signaling	15	2.09e-01	-0.188000	4.06e-01
Post-translational protein phosphorylation	69	7.37e-03	0.187000	3.38e-02
Maturation of hRSV A proteins	14	2.27e-01	-0.187000	4.27e-01
TP53 Regulates Transcription of Death Receptors and Ligands	8	3.61e-01	0.187000	5.72e-01
RHOH GTPase cycle	30	7.76e-02	-0.186000	2.04e-01
Maturation of spike protein 9694548	32	6.85e-02	0.186000	1.86e-01
Deubiquitination	160	5.43e-05	-0.186000	5.39e-04
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	5	4.74e-01	-0.185000	6.74e-01
Metabolism of steroids	82	3.99e-03	-0.185000	2.00e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	43	3.67e-02	-0.184000	1.18e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	5	4.77e-01	-0.184000	6.74e-01
ISG15 antiviral mechanism	63	1.19e-02	0.184000	4.93e-02
PKR-mediated signaling	51	2.36e-02	-0.184000	8.46e-02
Developmental Lineage of Pancreatic Ductal Cells	15	2.20e-01	0.183000	4.19e-01
Signaling by NOTCH3	25	1.14e-01	-0.183000	2.68e-01
Sulfur amino acid metabolism	20	1.58e-01	0.182000	3.41e-01
Early SARS-CoV-2 Infection Events	27	1.02e-01	-0.182000	2.47e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	166	6.09e-05	-0.182000	5.91e-04
Respiratory syncytial virus (RSV) genome replication, transcription and translation	17	1.96e-01	-0.181000	3.92e-01
Integrin signaling	20	1.62e-01	-0.181000	3.45e-01
Synthesis of PIPs at the plasma membrane	38	5.48e-02	-0.180000	1.58e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	63	1.39e-02	-0.180000	5.58e-02
Glutamate Neurotransmitter Release Cycle	16	2.15e-01	0.179000	4.13e-01
Loss of Function of TGFBR1 in Cancer	7	4.13e-01	0.179000	6.22e-01
Metabolic disorders of biological oxidation enzymes	15	2.32e-01	0.178000	4.32e-01
Noncanonical activation of NOTCH3	7	4.14e-01	-0.178000	6.22e-01
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	9	3.55e-01	0.178000	5.65e-01
Ion homeostasis	27	1.10e-01	-0.178000	2.61e-01
Developmental Cell Lineages	16	2.19e-01	0.178000	4.17e-01
Developmental Cell Lineages of the Exocrine Pancreas	16	2.19e-01	0.178000	4.17e-01
Signal amplification	17	2.05e-01	-0.178000	4.02e-01
Platelet sensitization by LDL	13	2.69e-01	-0.177000	4.77e-01
Striated Muscle Contraction	11	3.10e-01	-0.177000	5.21e-01
Formation of Incision Complex in GG-NER	33	7.92e-02	-0.177000	2.06e-01
Signaling by RAF1 mutants	34	7.59e-02	-0.176000	2.01e-01
Regulation of PD-L1(CD274) transcription	28	1.07e-01	0.176000	2.55e-01
Cargo recognition for clathrin-mediated endocytosis	71	1.06e-02	-0.176000	4.56e-02
Nucleotide Excision Repair	86	4.97e-03	-0.176000	2.38e-02
Negative regulation of FGFR4 signaling	14	2.55e-01	-0.176000	4.63e-01
RIP-mediated NFkB activation via ZBP1	11	3.15e-01	-0.175000	5.24e-01
ZBP1(DAI) mediated induction of type I IFNs	13	2.76e-01	-0.175000	4.83e-01
RHOJ GTPase cycle	48	3.66e-02	-0.175000	1.18e-01
MHC class II antigen presentation	92	3.94e-03	-0.175000	1.98e-02
rRNA processing	202	2.25e-05	-0.174000	2.65e-04
PKA-mediated phosphorylation of CREB	12	2.96e-01	-0.174000	5.04e-01
Malate-aspartate shuttle	8	3.94e-01	0.174000	6.02e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	77	8.66e-03	0.174000	3.87e-02
Regulation of PD-L1(CD274) Post-translational modification	73	1.06e-02	-0.173000	4.56e-02
Nuclear events mediated by NFE2L2	69	1.31e-02	-0.173000	5.36e-02
Interleukin-6 family signaling	11	3.20e-01	0.173000	5.28e-01
IRE1alpha activates chaperones	38	6.50e-02	-0.173000	1.79e-01
Nephrin family interactions	18	2.05e-01	-0.173000	4.02e-01
Negative regulation of MAPK pathway	28	1.14e-01	-0.173000	2.68e-01
FGFR1 mutant receptor activation	19	1.94e-01	0.172000	3.89e-01
SLC-mediated transport of inorganic anions	13	2.83e-01	-0.172000	4.88e-01
HIV Transcription Initiation	33	8.93e-02	-0.171000	2.25e-01
RNA Polymerase II HIV Promoter Escape	33	8.93e-02	-0.171000	2.25e-01
RNA Polymerase II Promoter Escape	33	8.93e-02	-0.171000	2.25e-01
RNA Polymerase II Transcription Initiation	33	8.93e-02	-0.171000	2.25e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	33	8.93e-02	-0.171000	2.25e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	33	8.93e-02	-0.171000	2.25e-01
Signaling by the B Cell Receptor (BCR)	75	1.08e-02	-0.171000	4.62e-02
Mitochondrial biogenesis	70	1.38e-02	0.171000	5.57e-02
SOS-mediated signalling	6	4.70e-01	0.171000	6.70e-01
Formation of the cornified envelope	50	3.76e-02	-0.170000	1.21e-01
Keratinization	50	3.76e-02	-0.170000	1.21e-01
Class I peroxisomal membrane protein import	18	2.12e-01	0.170000	4.08e-01
PERK regulates gene expression	24	1.49e-01	-0.170000	3.27e-01
Golgi-to-ER retrograde transport	110	2.19e-03	-0.170000	1.21e-02
Vesicle-mediated transport	515	1.14e-10	-0.170000	4.18e-09
GABA synthesis, release, reuptake and degradation	12	3.10e-01	0.169000	5.21e-01
APOBEC3G mediated resistance to HIV-1 infection	5	5.12e-01	0.169000	6.99e-01
XBP1(S) activates chaperone genes	36	7.96e-02	-0.169000	2.06e-01
PKA activation	11	3.32e-01	-0.169000	5.40e-01
RAC2 GTPase cycle	71	1.41e-02	-0.169000	5.65e-02
Myogenesis	12	3.13e-01	0.168000	5.22e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	2.60e-01	-0.168000	4.69e-01
Developmental Biology	692	2.74e-13	-0.168000	2.83e-11
Signaling by Leptin	6	4.77e-01	0.168000	6.75e-01
Transcription of the HIV genome	54	3.37e-02	-0.167000	1.11e-01
Processing of Intronless Pre-mRNAs	19	2.07e-01	-0.167000	4.04e-01
Cellular responses to mechanical stimuli	66	1.91e-02	-0.167000	7.20e-02
Metabolism of water-soluble vitamins and cofactors	79	1.05e-02	0.167000	4.53e-02
Polo-like kinase mediated events	7	4.45e-01	0.167000	6.49e-01
Transcriptional Regulation by NPAS4	16	2.50e-01	-0.166000	4.55e-01
Signaling by NOTCH1	40	6.97e-02	-0.166000	1.89e-01
InlA-mediated entry of Listeria monocytogenes into host cells	6	4.81e-01	0.166000	6.77e-01
Peptide ligand-binding receptors	14	2.83e-01	0.166000	4.88e-01
Signaling by LTK	8	4.17e-01	0.166000	6.25e-01
ATF6 (ATF6-alpha) activates chaperone genes	6	4.82e-01	0.166000	6.77e-01
MyD88-independent TLR4 cascade	65	2.13e-02	-0.166000	7.79e-02
TRIF (TICAM1)-mediated TLR4 signaling	65	2.13e-02	-0.166000	7.79e-02
Erythrocytes take up carbon dioxide and release oxygen	6	4.83e-01	0.166000	6.77e-01
O2/CO2 exchange in erythrocytes	6	4.83e-01	0.166000	6.77e-01
RHO GTPases activate PAKs	16	2.53e-01	0.165000	4.60e-01
KEAP1-NFE2L2 pathway	89	7.41e-03	-0.165000	3.38e-02
NRIF signals cell death from the nucleus	11	3.44e-01	-0.165000	5.53e-01
Regulation of beta-cell development	12	3.24e-01	-0.164000	5.32e-01
Response of endothelial cells to shear stress	61	2.70e-02	-0.164000	9.45e-02
Signaling by Rho GTPases	473	2.08e-09	-0.164000	6.07e-08
SARS-CoV-2 modulates autophagy	10	3.70e-01	0.164000	5.80e-01
Formation of TC-NER Pre-Incision Complex	41	7.09e-02	-0.163000	1.92e-01
FCERI mediated MAPK activation	25	1.59e-01	-0.163000	3.42e-01
CDC6 association with the ORC:origin complex	5	5.28e-01	-0.163000	7.13e-01
EGFR Transactivation by Gastrin	8	4.25e-01	0.163000	6.31e-01
Transcriptional regulation of granulopoiesis	22	1.87e-01	-0.163000	3.82e-01
Translesion Synthesis by POLH	13	3.11e-01	-0.162000	5.21e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	22	1.89e-01	0.162000	3.84e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	8	4.28e-01	0.162000	6.34e-01
Synthesis of PE	9	4.02e-01	0.161000	6.10e-01
Chondroitin sulfate/dermatan sulfate metabolism	24	1.71e-01	0.161000	3.57e-01
Translesion synthesis by POLK	12	3.34e-01	-0.161000	5.40e-01
Translesion synthesis by REV1	12	3.34e-01	-0.161000	5.40e-01
CASP8 activity is inhibited	8	4.31e-01	-0.161000	6.35e-01
Dimerization of procaspase-8	8	4.31e-01	-0.161000	6.35e-01
Regulation by c-FLIP	8	4.31e-01	-0.161000	6.35e-01
Gain-of-function MRAS complexes activate RAF signaling	6	4.96e-01	-0.161000	6.88e-01
SHOC2 M1731 mutant abolishes MRAS complex function	6	4.96e-01	-0.161000	6.88e-01
Signaling by MRAS-complex mutants	6	4.96e-01	-0.161000	6.88e-01
RNA Polymerase II Pre-transcription Events	61	3.07e-02	-0.160000	1.04e-01
Bicarbonate transporters	5	5.35e-01	-0.160000	7.18e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	3.18e-01	0.160000	5.26e-01
RNA Polymerase I Promoter Escape	28	1.44e-01	-0.160000	3.18e-01
RUNX3 regulates CDKN1A transcription	6	4.99e-01	0.160000	6.89e-01
Toll Like Receptor 9 (TLR9) Cascade	64	2.80e-02	-0.159000	9.69e-02
Glycogen storage diseases	7	4.66e-01	0.159000	6.68e-01
Galactose catabolism	5	5.39e-01	0.159000	7.20e-01
Dual incision in TC-NER	50	5.29e-02	-0.159000	1.55e-01
Diseases of metabolism	143	1.14e-03	0.158000	6.68e-03
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.59e-01	-0.158000	4.68e-01
Adaptive Immune System	487	4.99e-09	-0.158000	1.33e-07
Zinc transporters	9	4.13e-01	0.158000	6.22e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	16	2.76e-01	-0.157000	4.83e-01
Muscle contraction	67	2.71e-02	-0.157000	9.46e-02
Trafficking and processing of endosomal TLR	9	4.16e-01	0.157000	6.25e-01
GPCR downstream signalling	159	7.23e-04	-0.156000	4.51e-03
RHO GTPases activate PKNs	32	1.26e-01	-0.156000	2.90e-01
Disorders of Developmental Biology	11	3.70e-01	0.156000	5.80e-01
Regulation of TP53 Degradation	22	2.05e-01	-0.156000	4.02e-01
Regulation of TP53 Expression and Degradation	22	2.05e-01	-0.156000	4.02e-01
PI5P Regulates TP53 Acetylation	7	4.75e-01	0.156000	6.74e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	11	3.70e-01	-0.156000	5.80e-01
Defective EXT2 causes exostoses 2	11	3.70e-01	-0.156000	5.80e-01
Non-canonical inflammasome activation	6	5.10e-01	-0.155000	6.98e-01
Chaperone Mediated Autophagy	13	3.33e-01	-0.155000	5.40e-01
Separation of Sister Chromatids	133	2.17e-03	-0.155000	1.20e-02
Triglyceride biosynthesis	5	5.49e-01	-0.155000	7.28e-01
Glutamate and glutamine metabolism	12	3.54e-01	0.155000	5.64e-01
NGF-stimulated transcription	14	3.17e-01	0.155000	5.25e-01
Biological oxidations	77	1.95e-02	0.154000	7.31e-02
Signaling by FGFR3	22	2.11e-01	-0.154000	4.08e-01
Keratan sulfate/keratin metabolism	20	2.34e-01	0.154000	4.36e-01
Co-stimulation by CD28	31	1.40e-01	-0.153000	3.12e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	13	3.41e-01	0.153000	5.48e-01
Regulation of RUNX1 Expression and Activity	14	3.23e-01	-0.153000	5.31e-01
Signaling by FGFR4	22	2.16e-01	-0.153000	4.15e-01
Diseases associated with O-glycosylation of proteins	18	2.64e-01	-0.152000	4.71e-01
MyD88 cascade initiated on plasma membrane	58	4.54e-02	-0.152000	1.40e-01
Toll Like Receptor 10 (TLR10) Cascade	58	4.54e-02	-0.152000	1.40e-01
Toll Like Receptor 5 (TLR5) Cascade	58	4.54e-02	-0.152000	1.40e-01
Platelet homeostasis	40	9.68e-02	-0.152000	2.38e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	17	2.78e-01	-0.152000	4.85e-01
Trafficking of AMPA receptors	17	2.78e-01	-0.152000	4.85e-01
TP53 Regulates Transcription of Cell Cycle Genes	30	1.50e-01	-0.152000	3.28e-01
Signaling by Non-Receptor Tyrosine Kinases	33	1.32e-01	-0.152000	2.98e-01
Signaling by PTK6	33	1.32e-01	-0.152000	2.98e-01
Late endosomal microautophagy	24	1.99e-01	0.152000	3.95e-01
RHOBTB1 GTPase cycle	20	2.41e-01	-0.152000	4.44e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	32	1.39e-01	-0.151000	3.10e-01
MAPK targets/ Nuclear events mediated by MAP kinases	20	2.43e-01	-0.151000	4.46e-01
Hemostasis	358	1.44e-06	-0.150000	2.32e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	486	2.64e-08	-0.150000	6.27e-07
Signaling by WNT	167	8.85e-04	-0.150000	5.38e-03
MyD88 dependent cascade initiated on endosome	59	4.68e-02	-0.150000	1.43e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	59	4.68e-02	-0.150000	1.43e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	3.32e-01	-0.150000	5.40e-01
Downstream signaling of activated FGFR4	13	3.51e-01	-0.150000	5.61e-01
Processing of Capped Intronless Pre-mRNA	23	2.17e-01	-0.149000	4.16e-01
RHO GTPase Effectors	198	3.43e-04	-0.149000	2.45e-03
Telomere Maintenance	54	5.92e-02	-0.149000	1.66e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	36	1.23e-01	-0.149000	2.84e-01
Infectious disease	739	3.51e-11	-0.148000	1.47e-09
Regulated proteolysis of p75NTR	11	3.97e-01	-0.147000	6.05e-01
Toll Like Receptor 3 (TLR3) Cascade	64	4.19e-02	-0.147000	1.32e-01
Signaling by ERBB2 TMD/JMD mutants	14	3.40e-01	0.147000	5.48e-01
Plasma lipoprotein assembly	12	3.77e-01	0.147000	5.88e-01
Cellular response to chemical stress	141	2.68e-03	-0.147000	1.44e-02
Transferrin endocytosis and recycling	19	2.67e-01	-0.147000	4.76e-01
Signaling by MET	56	5.74e-02	-0.147000	1.63e-01
Thromboxane signalling through TP receptor	10	4.21e-01	-0.147000	6.30e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	3.11e-01	-0.146000	5.21e-01
TAK1-dependent IKK and NF-kappa-B activation	25	2.06e-01	-0.146000	4.03e-01
Metabolism of fat-soluble vitamins	29	1.73e-01	-0.146000	3.60e-01
Selective autophagy	65	4.25e-02	-0.146000	1.33e-01
Transcriptional regulation of white adipocyte differentiation	42	1.03e-01	-0.145000	2.48e-01
Activation of kainate receptors upon glutamate binding	11	4.05e-01	-0.145000	6.13e-01
Caspase activation via Death Receptors in the presence of ligand	9	4.51e-01	-0.145000	6.54e-01
Signaling by VEGF	79	2.66e-02	-0.145000	9.37e-02
Spry regulation of FGF signaling	11	4.06e-01	-0.145000	6.14e-01
DNA methylation	8	4.79e-01	0.145000	6.76e-01
Bile acid and bile salt metabolism	15	3.34e-01	0.144000	5.40e-01
Signaling by CSF3 (G-CSF)	18	2.90e-01	-0.144000	4.97e-01
Replacement of protamines by nucleosomes in the male pronucleus	5	5.77e-01	0.144000	7.47e-01
Initiation of Nuclear Envelope (NE) Reformation	19	2.78e-01	0.144000	4.85e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	50	7.88e-02	-0.144000	2.05e-01
Chylomicron remodeling	6	5.42e-01	0.144000	7.23e-01
Neddylation	124	6.10e-03	-0.143000	2.86e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	6	5.44e-01	0.143000	7.24e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	3.23e-01	-0.143000	5.31e-01
Neuronal System	156	2.27e-03	-0.143000	1.25e-02
mRNA decay by 3’ to 5’ exoribonuclease	16	3.25e-01	-0.142000	5.32e-01
Collagen degradation	26	2.10e-01	-0.142000	4.06e-01
Golgi Cisternae Pericentriolar Stack Reorganization	12	3.94e-01	-0.142000	6.02e-01
Signaling by TGF-beta Receptor Complex	66	4.69e-02	-0.142000	1.43e-01
G0 and Early G1	11	4.16e-01	-0.142000	6.24e-01
SHC-mediated cascade:FGFR4	8	4.88e-01	-0.142000	6.80e-01
Cytosolic tRNA aminoacylation	24	2.30e-01	0.142000	4.31e-01
ER to Golgi Anterograde Transport	129	5.82e-03	-0.141000	2.74e-02
Signaling by BRAF and RAF1 fusions	50	8.49e-02	-0.141000	2.18e-01
Advanced glycosylation endproduct receptor signaling	9	4.65e-01	-0.141000	6.67e-01
PI-3K cascade:FGFR4	7	5.19e-01	-0.141000	7.06e-01
GRB2 events in EGFR signaling	7	5.19e-01	0.141000	7.06e-01
Stimuli-sensing channels	31	1.77e-01	-0.140000	3.64e-01
ROBO receptors bind AKAP5	6	5.52e-01	0.140000	7.29e-01
Viral Infection Pathways	595	1.27e-08	-0.140000	3.10e-07
SARS-CoV-1 activates/modulates innate immune responses	27	2.09e-01	-0.140000	4.06e-01
Transcriptional Regulation by TP53	243	2.00e-04	-0.140000	1.58e-03
HATs acetylate histones	44	1.09e-01	-0.140000	2.59e-01
Signaling by GPCR	174	1.63e-03	-0.139000	9.32e-03
Metabolism of vitamins and cofactors	127	6.96e-03	0.139000	3.21e-02
Apoptotic cleavage of cell adhesion proteins	11	4.24e-01	-0.139000	6.31e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	10	4.48e-01	-0.139000	6.51e-01
Retinoid metabolism and transport	26	2.23e-01	-0.138000	4.22e-01
Interleukin-10 signaling	12	4.09e-01	0.138000	6.17e-01
POLB-Dependent Long Patch Base Excision Repair	7	5.29e-01	-0.138000	7.13e-01
Sema4D mediated inhibition of cell attachment and migration	7	5.29e-01	-0.138000	7.13e-01
WNT mediated activation of DVL	7	5.29e-01	-0.137000	7.13e-01
Transport and metabolism of PAPS	5	5.96e-01	-0.137000	7.61e-01
VEGFA-VEGFR2 Pathway	75	4.13e-02	-0.137000	1.30e-01
Disorders of Nervous System Development	8	5.04e-01	0.136000	6.92e-01
Loss of function of MECP2 in Rett syndrome	8	5.04e-01	0.136000	6.92e-01
Pervasive developmental disorders	8	5.04e-01	0.136000	6.92e-01
EGFR downregulation	20	2.92e-01	-0.136000	5.00e-01
Interleukin-6 signaling	9	4.80e-01	0.136000	6.76e-01
Ovarian tumor domain proteases	26	2.31e-01	-0.136000	4.31e-01
Cell surface interactions at the vascular wall	79	3.78e-02	-0.136000	1.21e-01
MET activates RAS signaling	8	5.09e-01	-0.135000	6.97e-01
Macroautophagy	109	1.55e-02	-0.135000	6.03e-02
Anchoring fibril formation	6	5.68e-01	-0.135000	7.44e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	60	7.23e-02	-0.134000	1.95e-01
PIP3 activates AKT signaling	159	3.74e-03	-0.134000	1.91e-02
Aryl hydrocarbon receptor signalling	5	6.04e-01	-0.134000	7.66e-01
Regulation of innate immune responses to cytosolic DNA	9	4.87e-01	-0.134000	6.80e-01
Transcriptional Regulation by VENTX	24	2.57e-01	-0.134000	4.65e-01
Apoptosis induced DNA fragmentation	13	4.04e-01	-0.134000	6.12e-01
Prolactin receptor signaling	7	5.41e-01	0.134000	7.22e-01
Signaling by ERBB2 KD Mutants	16	3.57e-01	0.133000	5.68e-01
Oncogenic MAPK signaling	59	7.77e-02	-0.133000	2.04e-01
Transport to the Golgi and subsequent modification	148	5.56e-03	-0.133000	2.62e-02
Signaling by Interleukins	226	6.57e-04	-0.133000	4.20e-03
RNA Pol II CTD phosphorylation and interaction with CE	24	2.62e-01	-0.132000	4.70e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	24	2.62e-01	-0.132000	4.70e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	37	1.64e-01	-0.132000	3.49e-01
Signaling by RAS mutants	37	1.64e-01	-0.132000	3.49e-01
Signaling by moderate kinase activity BRAF mutants	37	1.64e-01	-0.132000	3.49e-01
Signaling downstream of RAS mutants	37	1.64e-01	-0.132000	3.49e-01
Norepinephrine Neurotransmitter Release Cycle	10	4.69e-01	0.132000	6.69e-01
COPI-independent Golgi-to-ER retrograde traffic	43	1.34e-01	-0.132000	3.02e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	7	5.45e-01	-0.132000	7.25e-01
Non-integrin membrane-ECM interactions	53	9.66e-02	-0.132000	2.38e-01
Signaling by TGFB family members	101	2.23e-02	-0.132000	8.05e-02
Infection with Enterobacteria	19	3.19e-01	0.132000	5.27e-01
Late Phase of HIV Life Cycle	114	1.54e-02	0.132000	6.03e-02
Signaling by Erythropoietin	16	3.62e-01	-0.132000	5.72e-01
PI-3K cascade:FGFR1	7	5.46e-01	0.132000	7.25e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	5	6.12e-01	0.131000	7.70e-01
RNA Polymerase I Transcription Initiation	33	1.95e-01	-0.131000	3.91e-01
Cell Cycle Checkpoints	174	3.22e-03	-0.130000	1.69e-02
Insulin receptor recycling	19	3.27e-01	-0.130000	5.33e-01
CHL1 interactions	6	5.81e-01	0.130000	7.51e-01
Rab regulation of trafficking	96	2.86e-02	-0.130000	9.91e-02
Metalloprotease DUBs	14	4.01e-01	-0.130000	6.10e-01
Constitutive Signaling by AKT1 E17K in Cancer	20	3.17e-01	-0.129000	5.25e-01
Amino acid transport across the plasma membrane	18	3.43e-01	-0.129000	5.52e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	6	5.84e-01	-0.129000	7.53e-01
Unfolded Protein Response (UPR)	68	6.74e-02	-0.129000	1.84e-01
IFNG signaling activates MAPKs	6	5.86e-01	-0.129000	7.53e-01
Intracellular signaling by second messengers	185	2.86e-03	-0.128000	1.51e-02
Triglyceride catabolism	12	4.43e-01	0.128000	6.48e-01
Maternal to zygotic transition (MZT)	49	1.24e-01	-0.127000	2.84e-01
DNA Double-Strand Break Repair	79	5.16e-02	-0.127000	1.52e-01
Termination of translesion DNA synthesis	23	2.92e-01	-0.127000	5.00e-01
Synthesis of IP2, IP, and Ins in the cytosol	9	5.10e-01	-0.127000	6.98e-01
Unwinding of DNA	8	5.35e-01	-0.127000	7.18e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	10	4.90e-01	-0.126000	6.83e-01
Sensory processing of sound by outer hair cells of the cochlea	25	2.79e-01	-0.125000	4.85e-01
RHO GTPases Activate Formins	101	3.12e-02	-0.125000	1.05e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	27	2.64e-01	-0.124000	4.71e-01
Formation of the Early Elongation Complex	30	2.40e-01	-0.124000	4.43e-01
Formation of the HIV-1 Early Elongation Complex	30	2.40e-01	-0.124000	4.43e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	22	3.16e-01	-0.124000	5.24e-01
Regulation of IFNG signaling	8	5.45e-01	0.124000	7.25e-01
Retrograde neurotrophin signalling	10	4.99e-01	-0.124000	6.89e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	55	1.14e-01	0.123000	2.68e-01
Cell-Cell communication	185	4.10e-03	-0.123000	2.01e-02
Regulation of FOXO transcriptional activity by acetylation	8	5.46e-01	0.123000	7.25e-01
Formation of annular gap junctions	11	4.79e-01	-0.123000	6.76e-01
TCF dependent signaling in response to WNT	106	3.00e-02	-0.123000	1.03e-01
Signaling by NTRK1 (TRKA)	67	8.41e-02	-0.122000	2.17e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	86	5.07e-02	0.122000	1.51e-01
TRP channels	9	5.25e-01	0.122000	7.12e-01
Cell junction organization	164	7.33e-03	-0.122000	3.37e-02
Drug ADME	33	2.25e-01	0.122000	4.24e-01
Assembly of the ORC complex at the origin of replication	14	4.30e-01	-0.122000	6.35e-01
Activation of Matrix Metalloproteinases	11	4.85e-01	-0.122000	6.78e-01
RAS processing	17	3.85e-01	0.122000	5.96e-01
Transport of vitamins, nucleosides, and related molecules	20	3.47e-01	0.122000	5.55e-01
Chromosome Maintenance	63	9.80e-02	-0.121000	2.40e-01
Nuclear RNA decay	29	2.62e-01	-0.120000	4.70e-01
Signaling by FGFR1 in disease	25	3.00e-01	0.120000	5.08e-01
mRNA Capping	26	2.91e-01	-0.120000	5.00e-01
HDMs demethylate histones	13	4.57e-01	0.119000	6.60e-01
Signaling by Receptor Tyrosine Kinases	305	4.12e-04	-0.119000	2.85e-03
Influenza Infection	144	1.42e-02	-0.119000	5.65e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	13	4.58e-01	-0.119000	6.61e-01
Ca-dependent events	23	3.25e-01	-0.119000	5.32e-01
Class A/1 (Rhodopsin-like receptors)	23	3.27e-01	0.118000	5.33e-01
Cellular responses to stimuli	601	1.40e-06	-0.118000	2.27e-05
Regulation of FZD by ubiquitination	7	5.89e-01	0.118000	7.54e-01
Formation of the dystrophin-glycoprotein complex (DGC)	22	3.38e-01	-0.118000	5.46e-01
ATP-dependent chromatin remodelers	18	3.87e-01	0.118000	5.98e-01
SWI/SNF chromatin remodelers	18	3.87e-01	0.118000	5.98e-01
G2/M DNA damage checkpoint	41	1.93e-01	-0.118000	3.89e-01
Regulation of CDH1 Expression and Function	115	3.03e-02	-0.118000	1.03e-01
Regulation of Expression and Function of Type I Classical Cadherins	115	3.03e-02	-0.118000	1.03e-01
Signaling by NTRKs	76	7.89e-02	-0.117000	2.05e-01
RAF-independent MAPK1/3 activation	15	4.33e-01	-0.117000	6.37e-01
Mitotic Telophase/Cytokinesis	13	4.67e-01	0.116000	6.68e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	30	2.70e-01	-0.116000	4.77e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	30	2.70e-01	-0.116000	4.77e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	30	2.70e-01	-0.116000	4.77e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	30	2.70e-01	-0.116000	4.77e-01
Signaling by NOTCH1 in Cancer	30	2.70e-01	-0.116000	4.77e-01
Signaling by NTRK2 (TRKB)	16	4.21e-01	-0.116000	6.30e-01
Positive epigenetic regulation of rRNA expression	41	1.98e-01	-0.116000	3.95e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	49	1.60e-01	-0.116000	3.44e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	49	1.60e-01	-0.116000	3.44e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	49	1.60e-01	-0.116000	3.44e-01
Protein methylation	10	5.25e-01	-0.116000	7.12e-01
Transport of small molecules	364	1.80e-04	-0.116000	1.44e-03
mRNA Splicing - Minor Pathway	40	2.05e-01	-0.116000	4.02e-01
DNA Repair	180	7.70e-03	-0.116000	3.49e-02
Nuclear signaling by ERBB4	16	4.22e-01	0.116000	6.30e-01
ATF6 (ATF6-alpha) activates chaperones	8	5.70e-01	0.116000	7.45e-01
Formation of the polybromo-BAF (pBAF) complex	14	4.55e-01	0.116000	6.57e-01
Tight junction interactions	10	5.27e-01	-0.116000	7.13e-01
Signal attenuation	8	5.72e-01	-0.115000	7.45e-01
Other interleukin signaling	13	4.72e-01	0.115000	6.72e-01
Integration of provirus	9	5.49e-01	-0.115000	7.28e-01
Negative regulation of FGFR2 signaling	13	4.73e-01	-0.115000	6.72e-01
Negative regulation of FGFR3 signaling	13	4.73e-01	-0.115000	6.72e-01
RAF/MAP kinase cascade	150	1.58e-02	-0.115000	6.14e-02
G alpha (q) signalling events	62	1.19e-01	-0.115000	2.78e-01
FRS-mediated FGFR4 signaling	9	5.52e-01	-0.115000	7.29e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	12	4.93e-01	-0.114000	6.87e-01
Negative regulation of the PI3K/AKT network	54	1.49e-01	-0.114000	3.26e-01
CD28 dependent PI3K/Akt signaling	15	4.46e-01	-0.114000	6.50e-01
Formation of RNA Pol II elongation complex	49	1.69e-01	-0.114000	3.54e-01
RNA Polymerase II Transcription Elongation	49	1.69e-01	-0.114000	3.54e-01
Plasma lipoprotein assembly, remodeling, and clearance	41	2.10e-01	-0.113000	4.07e-01
MAPK family signaling cascades	181	9.36e-03	-0.113000	4.11e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	24	3.40e-01	0.113000	5.48e-01
Signaling by Insulin receptor	44	1.99e-01	-0.112000	3.95e-01
Signaling by CSF1 (M-CSF) in myeloid cells	21	3.75e-01	-0.112000	5.86e-01
Regulation of IFNA/IFNB signaling	8	5.84e-01	0.112000	7.53e-01
RMTs methylate histone arginines	31	2.83e-01	0.112000	4.88e-01
ABC transporters in lipid homeostasis	8	5.85e-01	-0.112000	7.53e-01
Lysosphingolipid and LPA receptors	5	6.66e-01	0.111000	8.08e-01
Transcriptional regulation by RUNX1	104	5.06e-02	-0.111000	1.51e-01
Generic Transcription Pathway	499	3.11e-05	-0.111000	3.46e-04
E2F mediated regulation of DNA replication	17	4.28e-01	-0.111000	6.34e-01
Anchoring of the basal body to the plasma membrane	73	1.02e-01	0.111000	2.47e-01
Negative regulation of MET activity	15	4.58e-01	-0.111000	6.61e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	16	4.45e-01	-0.110000	6.49e-01
Neurodegenerative Diseases	16	4.45e-01	-0.110000	6.49e-01
Zinc influx into cells by the SLC39 gene family	7	6.14e-01	0.110000	7.71e-01
IGF1R signaling cascade	24	3.51e-01	-0.110000	5.61e-01
Diseases associated with glycosylation precursor biosynthesis	14	4.77e-01	-0.110000	6.74e-01
SUMOylation of immune response proteins	7	6.15e-01	-0.110000	7.71e-01
EPH-ephrin mediated repulsion of cells	38	2.42e-01	-0.110000	4.45e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs	15	4.63e-01	-0.110000	6.66e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	27	3.25e-01	-0.110000	5.32e-01
Inflammasomes	13	4.95e-01	-0.109000	6.88e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	12	5.13e-01	0.109000	6.99e-01
Influenza Viral RNA Transcription and Replication	126	3.57e-02	-0.109000	1.16e-01
DNA Damage Bypass	34	2.73e-01	-0.109000	4.80e-01
Regulation of KIT signaling	9	5.72e-01	-0.109000	7.45e-01
CLEC7A/inflammasome pathway	5	6.74e-01	0.109000	8.16e-01
CD209 (DC-SIGN) signaling	16	4.52e-01	-0.109000	6.54e-01
Extra-nuclear estrogen signaling	46	2.04e-01	-0.109000	4.01e-01
MAPK1/MAPK3 signaling	155	2.09e-02	-0.108000	7.74e-02
CaM pathway	21	3.91e-01	-0.108000	6.01e-01
Calmodulin induced events	21	3.91e-01	-0.108000	6.01e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	4.84e-01	-0.108000	6.78e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	4.84e-01	-0.108000	6.78e-01
Regulation of T cell activation by CD28 family	141	2.77e-02	-0.108000	9.60e-02
Negative epigenetic regulation of rRNA expression	40	2.38e-01	-0.108000	4.41e-01
Signal Transduction	1280	1.02e-09	-0.108000	3.19e-08
Nuclear events stimulated by ALK signaling in cancer	22	3.83e-01	-0.107000	5.94e-01
RNA Polymerase II Transcription	593	1.33e-05	-0.107000	1.69e-04
Processive synthesis on the C-strand of the telomere	14	4.87e-01	-0.107000	6.80e-01
Packaging Of Telomere Ends	8	6.00e-01	0.107000	7.64e-01
Regulation of insulin secretion	37	2.61e-01	-0.107000	4.69e-01
SHC1 events in ERBB4 signaling	8	6.02e-01	0.107000	7.65e-01
Cellular responses to stress	538	3.71e-05	-0.106000	3.97e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	30	3.14e-01	0.106000	5.24e-01
Glycosaminoglycan metabolism	82	9.71e-02	0.106000	2.38e-01
Regulation of CDH1 Gene Transcription	33	2.91e-01	0.106000	5.00e-01
Respiratory Syncytial Virus Infection Pathway	79	1.04e-01	-0.106000	2.50e-01
Regulation of Homotypic Cell-Cell Adhesion	120	4.60e-02	-0.106000	1.41e-01
Interferon alpha/beta signaling	36	2.72e-01	-0.106000	4.79e-01
mRNA Splicing	175	1.67e-02	-0.106000	6.44e-02
mRNA Splicing - Major Pathway	175	1.67e-02	-0.106000	6.44e-02
Signaling by WNT in cancer	22	3.93e-01	0.105000	6.02e-01
Repression of WNT target genes	7	6.31e-01	0.105000	7.82e-01
TP53 Regulates Transcription of DNA Repair Genes	52	1.93e-01	-0.105000	3.89e-01
Maturation of protein 3a 9683673	6	6.59e-01	-0.104000	8.04e-01
Maturation of protein 3a 9694719	6	6.59e-01	-0.104000	8.04e-01
Cytosolic sulfonation of small molecules	5	6.89e-01	0.103000	8.29e-01
Role of ABL in ROBO-SLIT signaling	8	6.13e-01	-0.103000	7.70e-01
Negative Regulation of CDH1 Gene Transcription	28	3.46e-01	0.103000	5.55e-01
RHOG GTPase cycle	65	1.53e-01	-0.103000	3.32e-01
Inactivation of CSF3 (G-CSF) signaling	14	5.08e-01	-0.102000	6.96e-01
Crosslinking of collagen fibrils	8	6.17e-01	-0.102000	7.72e-01
RNA polymerase II transcribes snRNA genes	53	1.99e-01	-0.102000	3.95e-01
HS-GAG biosynthesis	17	4.66e-01	-0.102000	6.68e-01
Sensory Perception	81	1.14e-01	-0.102000	2.67e-01
Aspartate and asparagine metabolism	6	6.66e-01	-0.102000	8.08e-01
Assembly of collagen fibrils and other multimeric structures	30	3.35e-01	-0.102000	5.42e-01
Autophagy	121	5.47e-02	-0.102000	1.58e-01
Transcription of E2F targets under negative control by DREAM complex	8	6.20e-01	-0.101000	7.74e-01
HIV Life Cycle	125	5.21e-02	0.101000	1.53e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	22	4.13e-01	-0.101000	6.22e-01
Homology Directed Repair	56	1.93e-01	-0.101000	3.89e-01
NF-kB is activated and signals survival	8	6.22e-01	-0.101000	7.75e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	5	6.97e-01	0.101000	8.38e-01
Amyloid fiber formation	39	2.78e-01	-0.101000	4.85e-01
NFE2L2 regulates pentose phosphate pathway genes	7	6.46e-01	0.100000	7.93e-01
NoRC negatively regulates rRNA expression	38	2.85e-01	-0.100000	4.91e-01
Synthesis of bile acids and bile salts	14	5.17e-01	0.100000	7.04e-01
Pre-NOTCH Transcription and Translation	26	3.79e-01	-0.099900	5.90e-01
Regulation of PD-L1(CD274) translation	7	6.49e-01	0.099500	7.95e-01
Mitochondrial RNA degradation	21	4.32e-01	0.099100	6.36e-01
RNA Polymerase I Promoter Clearance	42	2.69e-01	-0.098800	4.77e-01
MET receptor recycling	8	6.29e-01	-0.098800	7.81e-01
The NLRP3 inflammasome	11	5.71e-01	-0.098700	7.45e-01
Telomere Extension By Telomerase	16	4.96e-01	-0.098300	6.88e-01
Platelet activation, signaling and aggregation	161	3.28e-02	-0.098100	1.10e-01
RUNX2 regulates osteoblast differentiation	13	5.41e-01	-0.098000	7.22e-01
FRS-mediated FGFR1 signaling	9	6.13e-01	0.097500	7.70e-01
Sialic acid metabolism	16	5.00e-01	0.097500	6.89e-01
Wax and plasmalogen biosynthesis	5	7.06e-01	-0.097300	8.42e-01
Cell-cell junction organization	142	4.72e-02	-0.097000	1.43e-01
SHC-mediated cascade:FGFR1	8	6.35e-01	0.096800	7.86e-01
Type I hemidesmosome assembly	9	6.15e-01	-0.096800	7.71e-01
Signal regulatory protein family interactions	6	6.83e-01	-0.096400	8.25e-01
DNA Damage/Telomere Stress Induced Senescence	28	3.78e-01	0.096300	5.90e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	6	6.84e-01	-0.096100	8.25e-01
Uptake and actions of bacterial toxins	22	4.37e-01	-0.095900	6.41e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	50	2.42e-01	-0.095800	4.45e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	25	4.08e-01	-0.095700	6.16e-01
Glycogen breakdown (glycogenolysis)	10	6.01e-01	-0.095700	7.64e-01
Immune System	1131	2.58e-07	-0.095600	4.88e-06
SUMOylation of intracellular receptors	9	6.20e-01	-0.095600	7.74e-01
HIV elongation arrest and recovery	30	3.67e-01	-0.095400	5.77e-01
Pausing and recovery of HIV elongation	30	3.67e-01	-0.095400	5.77e-01
G2/M Transition	143	5.14e-02	-0.094900	1.52e-01
Mitotic G2-G2/M phases	143	5.14e-02	-0.094900	1.52e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	3.00e-01	-0.094900	5.08e-01
Chylomicron assembly	7	6.64e-01	0.094700	8.08e-01
Regulation of TP53 Activity through Phosphorylation	51	2.43e-01	-0.094700	4.46e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	22	4.42e-01	0.094700	6.47e-01
Regulation of CDH11 mRNA translation by microRNAs	7	6.65e-01	0.094600	8.08e-01
Role of phospholipids in phagocytosis	20	4.66e-01	0.094300	6.68e-01
Neutrophil degranulation	343	3.15e-03	-0.094100	1.66e-02
ERK/MAPK targets	15	5.29e-01	-0.094100	7.13e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	12	5.74e-01	0.093800	7.45e-01
Co-inhibition by PD-1	109	9.29e-02	-0.093600	2.32e-01
Processing of DNA double-strand break ends	38	3.21e-01	-0.093100	5.29e-01
PKMTs methylate histone lysines	21	4.61e-01	0.093000	6.65e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	39	3.16e-01	-0.093000	5.24e-01
HIV Transcription Elongation	39	3.16e-01	-0.093000	5.24e-01
Tat-mediated elongation of the HIV-1 transcript	39	3.16e-01	-0.093000	5.24e-01
GAB1 signalosome	10	6.12e-01	-0.092800	7.70e-01
Pausing and recovery of Tat-mediated HIV elongation	29	3.88e-01	-0.092800	5.98e-01
Tat-mediated HIV elongation arrest and recovery	29	3.88e-01	-0.092800	5.98e-01
DAG and IP3 signaling	27	4.08e-01	-0.092200	6.16e-01
DAP12 interactions	21	4.66e-01	-0.092000	6.68e-01
RNA Polymerase III Transcription Termination	14	5.52e-01	0.091900	7.29e-01
Interleukin-12 signaling	37	3.35e-01	-0.091800	5.41e-01
Diseases associated with the TLR signaling cascade	18	5.01e-01	0.091700	6.90e-01
Diseases of Immune System	18	5.01e-01	0.091700	6.90e-01
RAB GEFs exchange GTP for GDP on RABs	72	1.80e-01	-0.091600	3.70e-01
Sema3A PAK dependent Axon repulsion	13	5.70e-01	-0.091100	7.44e-01
Formation of WDR5-containing histone-modifying complexes	17	5.17e-01	0.090900	7.04e-01
Scavenging by Class F Receptors	6	7.00e-01	0.090900	8.39e-01
Cytokine Signaling in Immune system	405	2.06e-03	-0.090800	1.15e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	51	2.64e-01	-0.090700	4.71e-01
Cell recruitment (pro-inflammatory response)	16	5.30e-01	-0.090600	7.13e-01
Purinergic signaling in leishmaniasis infection	16	5.30e-01	-0.090600	7.13e-01
Dopamine Neurotransmitter Release Cycle	13	5.72e-01	0.090600	7.45e-01
Translesion synthesis by POLI	13	5.74e-01	-0.090200	7.45e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	6	7.03e-01	-0.090100	8.40e-01
Signaling by FGFR2	44	3.02e-01	-0.090000	5.11e-01
O-glycosylation of TSR domain-containing proteins	8	6.59e-01	0.090000	8.04e-01
Diseases of signal transduction by growth factor receptors and second messengers	299	8.25e-03	-0.089900	3.71e-02
Phase 0 - rapid depolarisation	6	7.03e-01	-0.089800	8.40e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	5	7.28e-01	0.089700	8.58e-01
RNA Polymerase I Transcription	43	3.12e-01	-0.089400	5.21e-01
Phospholipid metabolism	135	7.53e-02	-0.089200	2.00e-01
Signaling by ALK fusions and activated point mutants	70	1.99e-01	-0.089100	3.95e-01
Signaling by ALK in cancer	70	1.99e-01	-0.089100	3.95e-01
Other semaphorin interactions	9	6.43e-01	-0.089100	7.91e-01
Acyl chain remodelling of PS	9	6.44e-01	-0.089100	7.91e-01
Sensory processing of sound	36	3.59e-01	-0.088500	5.70e-01
Adipogenesis	58	2.46e-01	-0.088400	4.49e-01
Disorders of transmembrane transporters	104	1.23e-01	0.088000	2.83e-01
Toll-like Receptor Cascades	98	1.35e-01	-0.087700	3.03e-01
Resolution of Abasic Sites (AP sites)	28	4.24e-01	-0.087400	6.31e-01
Toll Like Receptor 4 (TLR4) Cascade	81	1.76e-01	-0.087300	3.64e-01
HDR through Homologous Recombination (HRR)	28	4.25e-01	-0.087300	6.31e-01
HSF1 activation	20	5.00e-01	-0.087200	6.89e-01
Metabolism of RNA	634	2.78e-04	-0.087000	2.06e-03
Metabolism	1367	4.29e-07	0.086900	7.62e-06
Nonhomologous End-Joining (NHEJ)	27	4.36e-01	-0.086800	6.40e-01
Vitamin B5 (pantothenate) metabolism	13	5.89e-01	0.086700	7.54e-01
Platelet Aggregation (Plug Formation)	22	4.82e-01	-0.086700	6.77e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7	6	7.14e-01	-0.086400	8.48e-01
Sensory processing of sound by inner hair cells of the cochlea	33	3.92e-01	-0.086200	6.01e-01
RND1 GTPase cycle	32	4.02e-01	-0.085700	6.10e-01
IRS-related events triggered by IGF1R	23	4.79e-01	-0.085400	6.76e-01
Removal of the Flap Intermediate from the C-strand	13	5.95e-01	-0.085200	7.60e-01
Protein-protein interactions at synapses	40	3.53e-01	0.085000	5.63e-01
Downstream signaling of activated FGFR1	15	5.70e-01	0.084900	7.44e-01
Tie2 Signaling	12	6.12e-01	0.084700	7.70e-01
AURKA Activation by TPX2	64	2.43e-01	0.084600	4.46e-01
Regulation of NPAS4 gene expression	8	6.80e-01	0.084200	8.22e-01
Regulation of CDH11 Expression and Function	16	5.61e-01	0.084100	7.38e-01
Regulation of Expression and Function of Type II Classical Cadherins	16	5.61e-01	0.084100	7.38e-01
Signaling by EGFR in Cancer	15	5.73e-01	-0.084000	7.45e-01
SUMOylation of transcription cofactors	24	4.78e-01	-0.083700	6.76e-01
Phenylalanine metabolism	5	7.46e-01	-0.083600	8.70e-01
Adherens junctions interactions	130	1.02e-01	-0.083500	2.47e-01
Regulation of PD-L1(CD274) expression	106	1.40e-01	-0.083300	3.12e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	13	6.03e-01	0.083300	7.66e-01
Scavenging by Class A Receptors	12	6.18e-01	0.083300	7.72e-01
TGFBR3 regulates TGF-beta signaling	6	7.25e-01	-0.083100	8.54e-01
Activation of RAC1	9	6.70e-01	0.082200	8.12e-01
Cellular Senescence	89	1.82e-01	-0.082100	3.73e-01
Disease	1170	7.37e-06	-0.082100	1.03e-04
Signaling by ERBB2 in Cancer	17	5.60e-01	0.081800	7.38e-01
FOXO-mediated transcription of cell death genes	7	7.08e-01	0.081700	8.44e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	18	5.49e-01	-0.081700	7.28e-01
NCAM signaling for neurite out-growth	32	4.25e-01	-0.081600	6.31e-01
Innate Immune System	616	7.61e-04	-0.081600	4.71e-03
Downstream signaling of activated FGFR2	12	6.25e-01	-0.081500	7.77e-01
Downstream signaling of activated FGFR3	12	6.25e-01	-0.081500	7.77e-01
p130Cas linkage to MAPK signaling for integrins	13	6.12e-01	-0.081300	7.70e-01
Cytosolic sensors of pathogen-associated DNA	42	3.64e-01	-0.081000	5.76e-01
Cyclin D associated events in G1	26	4.76e-01	-0.080800	6.74e-01
G1 Phase	26	4.76e-01	-0.080800	6.74e-01
Respiratory electron transport	147	9.41e-02	0.080500	2.34e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	6	7.33e-01	-0.080500	8.61e-01
Visual phototransduction	40	3.81e-01	-0.080200	5.92e-01
DARPP-32 events	17	5.68e-01	0.080100	7.44e-01
Signaling by ALK	17	5.68e-01	0.080000	7.44e-01
Sphingolipid de novo biosynthesis	27	4.73e-01	-0.079900	6.72e-01
Release of apoptotic factors from the mitochondria	6	7.35e-01	0.079700	8.62e-01
Signaling by FGFR4 in disease	10	6.63e-01	-0.079500	8.07e-01
Regulation of signaling by CBL	13	6.22e-01	-0.079100	7.75e-01
CRMPs in Sema3A signaling	13	6.22e-01	0.078900	7.75e-01
PPARA activates gene expression	62	2.85e-01	-0.078700	4.91e-01
PINK1-PRKN Mediated Mitophagy	22	5.24e-01	-0.078600	7.11e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	5.99e-01	0.078400	7.64e-01
Loss of Nlp from mitotic centrosomes	61	2.94e-01	0.077900	5.02e-01
Loss of proteins required for interphase microtubule organization from the centrosome	61	2.94e-01	0.077900	5.02e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	64	2.83e-01	-0.077900	4.88e-01
Toll Like Receptor 2 (TLR2) Cascade	64	2.83e-01	-0.077900	4.88e-01
Toll Like Receptor TLR1:TLR2 Cascade	64	2.83e-01	-0.077900	4.88e-01
Toll Like Receptor TLR6:TLR2 Cascade	64	2.83e-01	-0.077900	4.88e-01
Signaling by TGFBR3	32	4.48e-01	-0.077600	6.51e-01
Role of LAT2/NTAL/LAB on calcium mobilization	14	6.16e-01	0.077400	7.72e-01
FCGR3A-mediated IL10 synthesis	26	4.96e-01	0.077200	6.88e-01
Insulin receptor signalling cascade	26	4.98e-01	-0.076900	6.89e-01
Regulation of PLK1 Activity at G2/M Transition	73	2.60e-01	0.076400	4.69e-01
TRAF6 mediated NF-kB activation	16	5.99e-01	-0.076000	7.64e-01
Regulation of lipid metabolism by PPARalpha	63	2.99e-01	-0.075900	5.08e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	63	2.99e-01	-0.075800	5.08e-01
O-linked glycosylation of mucins	23	5.30e-01	-0.075800	7.13e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	45	3.80e-01	-0.075700	5.91e-01
Constitutive Signaling by EGFRvIII	13	6.39e-01	-0.075100	7.88e-01
Signaling by EGFRvIII in Cancer	13	6.39e-01	-0.075100	7.88e-01
Cellular response to mitochondrial stress	8	7.13e-01	-0.075100	8.48e-01
MTOR signalling	37	4.32e-01	-0.074700	6.36e-01
Translation of Structural Proteins 9694635	44	3.92e-01	0.074700	6.01e-01
ATF4 activates genes in response to endoplasmic reticulum stress	19	5.74e-01	-0.074500	7.45e-01
MET promotes cell motility	28	5.03e-01	-0.073200	6.92e-01
Glycogen metabolism	14	6.39e-01	-0.072500	7.88e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	9	7.07e-01	0.072500	8.42e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	17	6.06e-01	-0.072400	7.67e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	17	6.06e-01	-0.072400	7.67e-01
Nucleotide catabolism	19	5.86e-01	0.072200	7.53e-01
Signaling by ERBB2 ECD mutants	14	6.40e-01	0.072200	7.88e-01
SUMO is proteolytically processed	5	7.80e-01	0.072100	8.92e-01
Metabolism of Angiotensinogen to Angiotensins	6	7.60e-01	-0.072100	8.79e-01
Degradation of the extracellular matrix	63	3.24e-01	-0.072100	5.32e-01
Integration of energy metabolism	58	3.46e-01	-0.071800	5.55e-01
E2F-enabled inhibition of pre-replication complex formation	7	7.43e-01	-0.071700	8.68e-01
Signaling by FGFR	53	3.69e-01	-0.071400	5.80e-01
Calcineurin activates NFAT	6	7.62e-01	-0.071400	8.79e-01
Metabolism of amino acids and derivatives	246	5.63e-02	-0.071400	1.60e-01
Ephrin signaling	16	6.22e-01	-0.071300	7.75e-01
RAS signaling downstream of NF1 loss-of-function variants	6	7.63e-01	-0.071000	8.79e-01
Meiotic recombination	20	5.85e-01	0.070700	7.53e-01
Regulation of TP53 Activity through Association with Co-factors	8	7.30e-01	-0.070500	8.59e-01
NFE2L2 regulating MDR associated enzymes	5	7.86e-01	0.070300	8.96e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	33	4.86e-01	0.070200	6.79e-01
FLT3 signaling in disease	18	6.08e-01	-0.070000	7.68e-01
PIWI-interacting RNA (piRNA) biogenesis	15	6.39e-01	-0.069900	7.88e-01
TGFBR3 expression	14	6.51e-01	-0.069900	7.98e-01
Translation of Structural Proteins 9683701	18	6.11e-01	-0.069300	7.70e-01
Bacterial Infection Pathways	72	3.11e-01	-0.069200	5.21e-01
Cleavage of the damaged purine	9	7.20e-01	0.069100	8.51e-01
Depurination	9	7.20e-01	0.069100	8.51e-01
Recognition and association of DNA glycosylase with site containing an affected purine	9	7.20e-01	0.069100	8.51e-01
HIV Infection	185	1.09e-01	-0.068900	2.59e-01
Transcriptional Regulation by E2F6	19	6.05e-01	-0.068500	7.67e-01
Acetylcholine regulates insulin secretion	6	7.72e-01	0.068500	8.84e-01
Opioid Signalling	51	4.02e-01	-0.067900	6.10e-01
FGFR2 alternative splicing	23	5.73e-01	-0.067900	7.45e-01
Downstream signal transduction	25	5.61e-01	-0.067200	7.38e-01
Anti-inflammatory response favouring Leishmania parasite infection	43	4.50e-01	-0.066700	6.52e-01
Leishmania parasite growth and survival	43	4.50e-01	-0.066700	6.52e-01
Regulation of CDH1 mRNA translation by microRNAs	7	7.61e-01	0.066400	8.79e-01
Formation of the embryonic stem cell BAF (esBAF) complex	13	6.79e-01	0.066400	8.21e-01
Oxidative Stress Induced Senescence	40	4.68e-01	-0.066400	6.69e-01
Budding and maturation of HIV virion	23	5.83e-01	0.066200	7.53e-01
Deactivation of the beta-catenin transactivating complex	22	5.91e-01	-0.066200	7.56e-01
RA biosynthesis pathway	11	7.04e-01	0.066100	8.41e-01
Estrogen-stimulated signaling through PRKCZ	6	7.79e-01	-0.066100	8.91e-01
Miscellaneous transport and binding events	17	6.38e-01	-0.065900	7.88e-01
Gene expression (Transcription)	720	3.56e-03	-0.065800	1.84e-02
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	15	6.60e-01	0.065600	8.04e-01
Complex I biogenesis	66	3.60e-01	-0.065300	5.71e-01
Signaling by FLT3 ITD and TKD mutants	10	7.21e-01	-0.065300	8.51e-01
RSV-host interactions	56	4.00e-01	-0.065200	6.09e-01
Heparan sulfate/heparin (HS-GAG) metabolism	23	5.90e-01	0.064900	7.56e-01
FCERI mediated Ca+2 mobilization	19	6.25e-01	0.064800	7.77e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	6	7.84e-01	-0.064600	8.95e-01
Energy dependent regulation of mTOR by LKB1-AMPK	26	5.70e-01	-0.064500	7.44e-01
SLC-mediated transport of amino acids	21	6.09e-01	-0.064500	7.69e-01
Cell Cycle	435	2.56e-02	-0.063600	9.06e-02
Interleukin receptor SHC signaling	11	7.16e-01	0.063400	8.49e-01
HDACs deacetylate histones	28	5.63e-01	0.063200	7.40e-01
Mitotic Anaphase	174	1.56e-01	-0.062900	3.36e-01
Mitotic Metaphase and Anaphase	174	1.56e-01	-0.062900	3.36e-01
Kidney development	10	7.34e-01	0.062200	8.61e-01
MASTL Facilitates Mitotic Progression	9	7.47e-01	0.062000	8.71e-01
Methionine salvage pathway	6	7.93e-01	0.061900	9.01e-01
Activation of HOX genes during differentiation	35	5.28e-01	-0.061700	7.13e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	35	5.28e-01	-0.061700	7.13e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	19	6.44e-01	0.061400	7.91e-01
Acyl chain remodelling of PE	10	7.38e-01	-0.061200	8.64e-01
MECP2 regulates neuronal receptors and channels	12	7.14e-01	0.061100	8.48e-01
SLC-mediated transport of organic anions	13	7.04e-01	-0.061000	8.40e-01
Neurotransmitter release cycle	28	5.81e-01	0.060300	7.51e-01
HSF1-dependent transactivation	25	6.04e-01	0.060000	7.66e-01
CLEC7A (Dectin-1) induces NFAT activation	8	7.70e-01	0.059800	8.82e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	25	6.07e-01	0.059500	7.68e-01
Synthesis of IP3 and IP4 in the cytosol	14	7.00e-01	-0.059500	8.39e-01
Organelle biogenesis and maintenance	197	1.54e-01	0.059400	3.33e-01
Sphingolipid metabolism	64	4.20e-01	0.058400	6.29e-01
Iron uptake and transport	39	5.31e-01	-0.058000	7.14e-01
RNA Polymerase III Abortive And Retractive Initiation	23	6.31e-01	0.058000	7.82e-01
RNA Polymerase III Transcription	23	6.31e-01	0.058000	7.82e-01
rRNA modification in the nucleus and cytosol	55	4.62e-01	-0.057500	6.65e-01
Signaling by KIT in disease	16	6.95e-01	0.056700	8.35e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	6.95e-01	0.056700	8.35e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	23	6.38e-01	0.056700	7.88e-01
EML4 and NUDC in mitotic spindle formation	81	3.80e-01	-0.056600	5.91e-01
ESR-mediated signaling	107	3.14e-01	-0.056600	5.24e-01
Heme signaling	21	6.55e-01	-0.056500	8.01e-01
Ca2+ pathway	31	5.88e-01	-0.056300	7.54e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	6	8.12e-01	-0.056200	9.13e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	8	7.83e-01	-0.056100	8.94e-01
Acyl chain remodelling of PG	6	8.12e-01	-0.056000	9.13e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	19	6.74e-01	-0.055800	8.16e-01
Collagen formation	47	5.11e-01	-0.055500	6.98e-01
Post-transcriptional silencing by small RNAs	5	8.31e-01	-0.055100	9.24e-01
Epigenetic regulation of gene expression	143	2.58e-01	-0.055100	4.67e-01
Inactivation, recovery and regulation of the phototransduction cascade	10	7.65e-01	0.054500	8.79e-01
The phototransduction cascade	10	7.65e-01	0.054500	8.79e-01
G-protein mediated events	34	5.84e-01	-0.054400	7.53e-01
Modulation of host responses by IFN-stimulated genes	13	7.35e-01	-0.054300	8.62e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	66	4.47e-01	0.054200	6.51e-01
Amplification of signal from the kinetochores	66	4.47e-01	0.054200	6.51e-01
Cyclin A/B1/B2 associated events during G2/M transition	17	7.04e-01	0.053300	8.40e-01
NR1H2 and NR1H3-mediated signaling	23	6.61e-01	-0.052800	8.05e-01
G1/S-Specific Transcription	11	7.62e-01	-0.052800	8.79e-01
Pyroptosis	18	7.00e-01	-0.052600	8.39e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	12	7.56e-01	0.051900	8.76e-01
AMPK inhibits chREBP transcriptional activation activity	5	8.41e-01	-0.051900	9.30e-01
Ribavirin ADME	9	7.90e-01	-0.051400	8.99e-01
Nicotinate metabolism	14	7.40e-01	0.051200	8.65e-01
HDL remodeling	6	8.28e-01	-0.051100	9.22e-01
Interleukin-12 family signaling	42	5.68e-01	-0.051000	7.44e-01
Telomere C-strand synthesis initiation	8	8.03e-01	-0.051000	9.08e-01
RHOD GTPase cycle	46	5.53e-01	-0.050700	7.30e-01
Regulation of TP53 Activity	95	3.96e-01	-0.050600	6.04e-01
PI3K/AKT Signaling in Cancer	48	5.46e-01	-0.050400	7.25e-01
Nuclear Receptor transcription pathway	12	7.63e-01	-0.050400	8.79e-01
Regulation of endogenous retroelements	44	5.65e-01	0.050200	7.42e-01
Interleukin-37 signaling	12	7.65e-01	-0.049900	8.79e-01
Josephin domain DUBs	5	8.47e-01	-0.049800	9.34e-01
Defective pyroptosis	16	7.32e-01	0.049500	8.61e-01
eNOS activation	12	7.67e-01	0.049300	8.80e-01
TP53 Regulates Transcription of Cell Death Genes	27	6.58e-01	-0.049300	8.04e-01
Pexophagy	6	8.35e-01	-0.049100	9.26e-01
RAB geranylgeranylation	53	5.38e-01	-0.049000	7.20e-01
Translation	349	1.22e-01	0.048900	2.82e-01
N-Glycan antennae elongation	9	8.01e-01	-0.048600	9.07e-01
Attenuation phase	18	7.22e-01	-0.048500	8.52e-01
Deposition of new CENPA-containing nucleosomes at the centromere	14	7.55e-01	0.048300	8.75e-01
Nucleosome assembly	14	7.55e-01	0.048300	8.75e-01
tRNA processing in the mitochondrion	17	7.33e-01	-0.047900	8.61e-01
Response to elevated platelet cytosolic Ca2+	87	4.42e-01	0.047900	6.47e-01
RHOBTB3 ATPase cycle	7	8.27e-01	-0.047600	9.22e-01
Reactions specific to the complex N-glycan synthesis pathway	6	8.41e-01	0.047200	9.30e-01
Cell Cycle, Mitotic	365	1.28e-01	-0.047100	2.92e-01
Cytochrome P450 - arranged by substrate type	17	7.39e-01	-0.046600	8.65e-01
G alpha (i) signalling events	71	4.99e-01	-0.046600	6.89e-01
ERBB2 Regulates Cell Motility	7	8.32e-01	0.046400	9.24e-01
RHO GTPases activate CIT	15	7.56e-01	0.046300	8.76e-01
Antiviral mechanism by IFN-stimulated genes	113	3.98e-01	0.046300	6.06e-01
O-linked glycosylation	48	5.81e-01	0.046200	7.51e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	5	8.60e-01	0.045700	9.35e-01
Fatty acyl-CoA biosynthesis	24	7.00e-01	0.045500	8.39e-01
Semaphorin interactions	45	5.99e-01	-0.045400	7.64e-01
Glycosaminoglycan-protein linkage region biosynthesis	20	7.26e-01	-0.045300	8.56e-01
Estrogen-dependent gene expression	62	5.39e-01	-0.045300	7.20e-01
Nucleotide salvage	15	7.62e-01	-0.045300	8.79e-01
Signaling by PDGF	41	6.17e-01	-0.045200	7.72e-01
Collagen chain trimerization	15	7.62e-01	-0.045100	8.79e-01
Triglyceride metabolism	17	7.49e-01	0.044800	8.72e-01
SARS-CoV-2-host interactions	159	3.37e-01	-0.044400	5.44e-01
Activated NTRK2 signals through RAS	6	8.51e-01	-0.044400	9.34e-01
Activated NTRK3 signals through RAS	6	8.51e-01	-0.044400	9.34e-01
Base Excision Repair	36	6.47e-01	-0.044200	7.94e-01
SARS-CoV Infections	313	1.86e-01	-0.044000	3.81e-01
Phase I - Functionalization of compounds	36	6.51e-01	0.043600	7.98e-01
Diseases associated with glycosaminoglycan metabolism	26	7.03e-01	-0.043200	8.40e-01
Centrosome maturation	69	5.37e-01	0.043100	7.20e-01
Recruitment of mitotic centrosome proteins and complexes	69	5.37e-01	0.043100	7.20e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	9	8.24e-01	0.042900	9.20e-01
Synthesis of pyrophosphates in the cytosol	5	8.69e-01	0.042700	9.38e-01
Netrin-1 signaling	24	7.18e-01	0.042700	8.50e-01
Azathioprine ADME	15	7.77e-01	0.042400	8.89e-01
Metal ion SLC transporters	20	7.44e-01	-0.042300	8.68e-01
MAPK1 (ERK2) activation	8	8.38e-01	0.041700	9.29e-01
Platelet degranulation	83	5.13e-01	0.041700	6.99e-01
Potential therapeutics for SARS	69	5.51e-01	-0.041600	7.29e-01
Signaling by SCF-KIT	26	7.17e-01	-0.041100	8.50e-01
Formation of the canonical BAF (cBAF) complex	13	8.00e-01	0.040700	9.06e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	8.24e-01	-0.040600	9.20e-01
Signaling by BMP	14	7.93e-01	0.040500	9.01e-01
Signaling by FGFR in disease	41	6.59e-01	0.039900	8.04e-01
Sema4D in semaphorin signaling	19	7.64e-01	-0.039800	8.79e-01
CS-GAG biosynthesis	15	7.90e-01	0.039700	8.99e-01
Extracellular matrix organization	167	3.81e-01	-0.039500	5.92e-01
Processing of Capped Intron-Containing Pre-mRNA	238	2.99e-01	0.039500	5.08e-01
Negative regulation of FGFR1 signaling	14	7.99e-01	-0.039400	9.05e-01
Synthesis of very long-chain fatty acyl-CoAs	13	8.06e-01	0.039300	9.09e-01
TRAF6 mediated IRF7 activation	11	8.23e-01	0.039100	9.20e-01
SHC1 events in EGFR signaling	8	8.50e-01	0.038700	9.34e-01
Signaling by cytosolic FGFR1 fusion mutants	15	7.95e-01	0.038700	9.02e-01
Metabolism of proteins	1375	2.49e-02	0.038500	8.84e-02
2-LTR circle formation	7	8.65e-01	-0.037000	9.37e-01
Assembly of active LPL and LIPC lipase complexes	9	8.48e-01	0.036900	9.34e-01
Synthesis of substrates in N-glycan biosythesis	41	6.84e-01	0.036800	8.25e-01
Diseases of programmed cell death	40	6.89e-01	-0.036700	8.29e-01
DNA Double Strand Break Response	35	7.10e-01	-0.036400	8.45e-01
Signaling by FLT3 fusion proteins	14	8.14e-01	0.036300	9.15e-01
Formation of the beta-catenin:TCF transactivating complex	25	7.55e-01	0.036200	8.75e-01
MAPK3 (ERK1) activation	9	8.52e-01	-0.036000	9.34e-01
Reproduction	42	6.89e-01	-0.035800	8.29e-01
SARS-CoV-2 Infection	229	3.60e-01	-0.035400	5.71e-01
STING mediated induction of host immune responses	13	8.25e-01	-0.035400	9.20e-01
Linoleic acid (LA) metabolism	6	8.82e-01	-0.034900	9.47e-01
Interleukin-2 family signaling	15	8.16e-01	-0.034800	9.15e-01
Vitamin C (ascorbate) metabolism	6	8.83e-01	-0.034700	9.47e-01
Defective Intrinsic Pathway for Apoptosis	18	8.05e-01	-0.033600	9.08e-01
PLC beta mediated events	31	7.50e-01	-0.033200	8.72e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	5	8.98e-01	0.033100	9.53e-01
Erythropoietin activates RAS	9	8.63e-01	-0.033100	9.37e-01
HS-GAG degradation	15	8.25e-01	0.033100	9.20e-01
RNA Polymerase I Promoter Opening	9	8.64e-01	0.033000	9.37e-01
MITF-M-dependent gene expression	70	6.34e-01	-0.033000	7.85e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	13	8.37e-01	0.032900	9.28e-01
Smooth Muscle Contraction	24	7.81e-01	0.032800	8.92e-01
Formation of the non-canonical BAF (ncBAF) complex	10	8.58e-01	0.032600	9.35e-01
RND2 GTPase cycle	34	7.44e-01	-0.032400	8.69e-01
mTORC1-mediated signalling	22	7.94e-01	0.032200	9.01e-01
Regulation of NPAS4 mRNA translation	6	8.92e-01	-0.032000	9.53e-01
Host Interactions of HIV factors	104	5.77e-01	-0.031800	7.47e-01
MITF-M-regulated melanocyte development	99	5.87e-01	-0.031800	7.53e-01
RAF activation	29	7.68e-01	-0.031700	8.80e-01
HDR through MMEJ (alt-NHEJ)	8	8.77e-01	0.031700	9.45e-01
Condensation of Prophase Chromosomes	15	8.34e-01	-0.031300	9.26e-01
Listeria monocytogenes entry into host cells	15	8.34e-01	-0.031200	9.26e-01
TRAF3-dependent IRF activation pathway	10	8.66e-01	-0.030900	9.37e-01
NCAM1 interactions	14	8.43e-01	-0.030500	9.31e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	17	8.28e-01	0.030500	9.22e-01
Signaling by LTK in cancer	7	8.90e-01	-0.030300	9.52e-01
Cohesin Loading onto Chromatin	10	8.69e-01	0.030200	9.38e-01
HDR through Single Strand Annealing (SSA)	20	8.16e-01	0.030100	9.15e-01
VEGFR2 mediated vascular permeability	20	8.18e-01	-0.029800	9.17e-01
Alpha-oxidation of phytanate	5	9.09e-01	0.029600	9.58e-01
Signaling by NTRK3 (TRKC)	14	8.48e-01	0.029500	9.34e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	20	8.19e-01	0.029500	9.18e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	7	8.93e-01	0.029500	9.53e-01
Keratan sulfate biosynthesis	14	8.49e-01	-0.029400	9.34e-01
Metabolism of lipids	434	3.04e-01	0.029300	5.13e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	6	9.02e-01	-0.029100	9.53e-01
SLBP independent Processing of Histone Pre-mRNAs	6	9.02e-01	-0.029100	9.53e-01
Negative regulators of DDX58/IFIH1 signaling	23	8.10e-01	-0.029000	9.12e-01
Phenylalanine and tyrosine metabolism	7	8.95e-01	-0.028800	9.53e-01
Beta-catenin phosphorylation cascade	13	8.59e-01	0.028500	9.35e-01
CTNNB1 S33 mutants aren’t phosphorylated	13	8.59e-01	0.028500	9.35e-01
CTNNB1 S37 mutants aren’t phosphorylated	13	8.59e-01	0.028500	9.35e-01
CTNNB1 S45 mutants aren’t phosphorylated	13	8.59e-01	0.028500	9.35e-01
CTNNB1 T41 mutants aren’t phosphorylated	13	8.59e-01	0.028500	9.35e-01
Signaling by CTNNB1 phospho-site mutants	13	8.59e-01	0.028500	9.35e-01
Signaling by GSK3beta mutants	13	8.59e-01	0.028500	9.35e-01
COPII-mediated vesicle transport	57	7.13e-01	0.028200	8.48e-01
Neurexins and neuroligins	24	8.11e-01	0.028200	9.13e-01
Interferon gamma signaling	47	7.39e-01	-0.028200	8.65e-01
Acyl chain remodelling of PC	10	8.78e-01	-0.028100	9.46e-01
Pre-NOTCH Processing in Golgi	12	8.67e-01	0.028000	9.37e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	26	8.05e-01	-0.028000	9.08e-01
RNA Polymerase II Transcription Termination	56	7.18e-01	-0.028000	8.50e-01
Processing and activation of SUMO	8	8.93e-01	0.027500	9.53e-01
Regulation of gene expression in beta cells	6	9.07e-01	-0.027500	9.58e-01
Signaling by FGFR3 in disease	10	8.83e-01	0.026900	9.47e-01
SHC1 events in ERBB2 signaling	14	8.62e-01	-0.026800	9.37e-01
Regulation of NF-kappa B signaling	12	8.73e-01	-0.026700	9.41e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	11	8.80e-01	0.026200	9.47e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	34	7.93e-01	-0.026000	9.01e-01
Transcriptional regulation of brown and beige adipocyte differentiation	17	8.53e-01	0.025900	9.35e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	17	8.53e-01	0.025900	9.35e-01
M Phase	280	4.68e-01	-0.025500	6.68e-01
mRNA 3’-end processing	52	7.51e-01	-0.025500	8.74e-01
Asparagine N-linked glycosylation	241	5.04e-01	-0.025300	6.92e-01
Pre-NOTCH Expression and Processing	38	7.88e-01	-0.025300	8.98e-01
Vitamin D (calciferol) metabolism	6	9.16e-01	-0.024900	9.62e-01
VEGFR2 mediated cell proliferation	16	8.65e-01	-0.024500	9.37e-01
Proton-coupled monocarboxylate transport	5	9.25e-01	0.024400	9.65e-01
SHC-mediated cascade:FGFR2	7	9.12e-01	-0.024000	9.60e-01
SHC-mediated cascade:FGFR3	7	9.12e-01	-0.024000	9.60e-01
Activated NTRK2 signals through FRS2 and FRS3	7	9.15e-01	-0.023400	9.62e-01
Regulation of MITF-M-dependent genes involved in apoptosis	13	8.84e-01	0.023400	9.47e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	13	8.85e-01	0.023100	9.48e-01
Receptor Mediated Mitophagy	8	9.10e-01	-0.023000	9.59e-01
Syndecan interactions	24	8.49e-01	-0.022400	9.34e-01
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	9	9.08e-01	-0.022200	9.58e-01
FOXO-mediated transcription	34	8.23e-01	0.022200	9.20e-01
RUNX2 regulates bone development	17	8.79e-01	-0.021400	9.46e-01
Defective B3GALTL causes PpS	7	9.22e-01	0.021300	9.65e-01
DCC mediated attractive signaling	12	9.00e-01	0.020900	9.53e-01
APC truncation mutants have impaired AXIN binding	12	9.02e-01	-0.020600	9.53e-01
AXIN missense mutants destabilize the destruction complex	12	9.02e-01	-0.020600	9.53e-01
Signaling by AMER1 mutants	12	9.02e-01	-0.020600	9.53e-01
Signaling by APC mutants	12	9.02e-01	-0.020600	9.53e-01
Signaling by AXIN mutants	12	9.02e-01	-0.020600	9.53e-01
Truncations of AMER1 destabilize the destruction complex	12	9.02e-01	-0.020600	9.53e-01
Signaling by Activin	11	9.08e-01	0.020100	9.58e-01
SIRT1 negatively regulates rRNA expression	8	9.21e-01	0.020100	9.65e-01
Late SARS-CoV-2 Infection Events	49	8.09e-01	0.020000	9.12e-01
Regulation of PTEN mRNA translation	9	9.19e-01	0.019500	9.64e-01
Nuclear Events (kinase and transcription factor activation)	30	8.54e-01	0.019500	9.35e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	36	8.41e-01	0.019400	9.30e-01
Resolution of Sister Chromatid Cohesion	90	7.55e-01	-0.019100	8.75e-01
Glycogen synthesis	6	9.37e-01	-0.018700	9.73e-01
NOTCH1 Intracellular Domain Regulates Transcription	22	8.79e-01	-0.018700	9.46e-01
Meiosis	38	8.43e-01	0.018600	9.31e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	8	9.27e-01	0.018600	9.68e-01
FGFR2 mutant receptor activation	16	8.98e-01	-0.018500	9.53e-01
Signaling by FGFR2 IIIa TM	16	8.98e-01	-0.018500	9.53e-01
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	28	8.71e-01	-0.017800	9.40e-01
Integrin cell surface interactions	50	8.29e-01	-0.017700	9.23e-01
Diseases of DNA repair	23	8.84e-01	-0.017600	9.47e-01
Platelet calcium homeostasis	17	9.01e-01	-0.017400	9.53e-01
GP1b-IX-V activation signalling	6	9.42e-01	0.017200	9.76e-01
Inactivation of CDC42 and RAC1	7	9.38e-01	-0.016900	9.74e-01
GPCR ligand binding	45	8.45e-01	-0.016800	9.32e-01
RET signaling	20	8.97e-01	-0.016700	9.53e-01
Acyl chain remodeling of CL	5	9.48e-01	0.016700	9.78e-01
Constitutive Signaling by Overexpressed ERBB2	11	9.24e-01	0.016600	9.65e-01
Post-translational protein modification	888	4.27e-01	-0.016400	6.33e-01
Notch-HLH transcription pathway	12	9.23e-01	0.016100	9.65e-01
Purine salvage	10	9.31e-01	0.015900	9.69e-01
Regulation of PTEN gene transcription	41	8.62e-01	0.015700	9.37e-01
ECM proteoglycans	40	8.66e-01	0.015400	9.37e-01
Synthesis of dolichyl-phosphate	7	9.45e-01	-0.015100	9.76e-01
Complex IV assembly	42	8.66e-01	0.015100	9.37e-01
Regulation of TP53 Activity through Acetylation	23	9.01e-01	-0.015000	9.53e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	8	9.42e-01	-0.014800	9.76e-01
Recruitment of NuMA to mitotic centrosomes	78	8.22e-01	-0.014800	9.20e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	11	9.33e-01	-0.014700	9.70e-01
SLC-mediated transmembrane transport	101	8.04e-01	-0.014300	9.08e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	15	9.24e-01	0.014300	9.65e-01
Establishment of Sister Chromatid Cohesion	8	9.45e-01	0.014100	9.76e-01
Interferon Signaling	167	7.65e-01	0.013500	8.79e-01
RUNX3 regulates p14-ARF	9	9.44e-01	-0.013500	9.76e-01
Transport of RCbl within the body	5	9.59e-01	-0.013200	9.83e-01
Amino acids regulate mTORC1	34	8.95e-01	-0.013100	9.53e-01
Signaling by Nuclear Receptors	144	8.01e-01	-0.012200	9.07e-01
Intraflagellar transport	26	9.15e-01	-0.012100	9.62e-01
Evasion by RSV of host interferon responses	17	9.32e-01	0.012000	9.70e-01
Inhibition of DNA recombination at telomere	20	9.28e-01	-0.011600	9.68e-01
CaMK IV-mediated phosphorylation of CREB	7	9.60e-01	0.010900	9.83e-01
SUMOylation of DNA methylation proteins	7	9.61e-01	-0.010700	9.83e-01
Signaling by ERBB4	28	9.22e-01	-0.010700	9.65e-01
Plasma lipoprotein remodeling	17	9.41e-01	0.010400	9.75e-01
Synthesis of PG	7	9.62e-01	0.010400	9.84e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	9.51e-01	-0.010300	9.80e-01
Interleukin-7 signaling	10	9.55e-01	-0.010300	9.83e-01
N-glycan antennae elongation in the medial/trans-Golgi	15	9.45e-01	-0.010300	9.76e-01
Regulation of MECP2 expression and activity	22	9.35e-01	-0.010100	9.72e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	37	9.16e-01	-0.010000	9.62e-01
Zygotic genome activation (ZGA)	6	9.66e-01	-0.009950	9.85e-01
Chromatin organization	113	8.57e-01	0.009890	9.35e-01
Mitotic Spindle Checkpoint	78	8.82e-01	-0.009770	9.47e-01
SUMOylation of transcription factors	9	9.60e-01	-0.009680	9.83e-01
Mitotic Prometaphase	156	8.41e-01	-0.009370	9.30e-01
Free fatty acids regulate insulin secretion	5	9.73e-01	0.008840	9.86e-01
Diseases of glycosylation	77	8.94e-01	0.008810	9.53e-01
Signaling by FGFR1	28	9.37e-01	-0.008600	9.73e-01
Interleukin-4 and Interleukin-13 signaling	45	9.23e-01	-0.008340	9.65e-01
Meiotic synapsis	23	9.46e-01	0.008210	9.76e-01
FRS-mediated FGFR2 signaling	8	9.68e-01	-0.008210	9.85e-01
FRS-mediated FGFR3 signaling	8	9.68e-01	-0.008210	9.85e-01
HuR (ELAVL1) binds and stabilizes mRNA	8	9.69e-01	-0.007980	9.86e-01
Collagen biosynthesis and modifying enzymes	31	9.39e-01	-0.007940	9.74e-01
Molybdenum cofactor biosynthesis	6	9.74e-01	-0.007580	9.87e-01
Regulation of MITF-M-dependent genes involved in pigmentation	22	9.53e-01	0.007300	9.81e-01
PI3K Cascade	17	9.59e-01	-0.007190	9.83e-01
Synthesis of PC	18	9.60e-01	0.006830	9.83e-01
MET activates PTK2 signaling	20	9.63e-01	0.005930	9.85e-01
Synthesis of PA	24	9.61e-01	0.005800	9.83e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	17	9.67e-01	-0.005750	9.85e-01
Diseases of DNA Double-Strand Break Repair	17	9.67e-01	-0.005750	9.85e-01
Impaired BRCA2 binding to RAD51	17	9.67e-01	-0.005750	9.85e-01
RHO GTPases Activate ROCKs	14	9.70e-01	-0.005730	9.86e-01
Constitutive Signaling by Aberrant PI3K in Cancer	27	9.60e-01	0.005600	9.83e-01
ERKs are inactivated	11	9.75e-01	0.005500	9.87e-01
EPHA-mediated growth cone collapse	15	9.72e-01	0.005300	9.86e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	14	9.73e-01	0.005160	9.86e-01
Post-translational modification: synthesis of GPI-anchored proteins	31	9.61e-01	0.005070	9.83e-01
Signaling by FGFR2 in disease	25	9.65e-01	-0.005020	9.85e-01
Chromatin modifying enzymes	109	9.29e-01	0.004970	9.68e-01
TGF-beta receptor signaling activates SMADs	34	9.61e-01	0.004910	9.83e-01
IRS-mediated signalling	21	9.70e-01	-0.004800	9.86e-01
Homologous DNA Pairing and Strand Exchange	18	9.72e-01	-0.004790	9.86e-01
Presynaptic phase of homologous DNA pairing and strand exchange	18	9.72e-01	-0.004790	9.86e-01
DAP12 signaling	18	9.76e-01	0.004030	9.88e-01
Cilium Assembly	127	9.47e-01	-0.003450	9.77e-01
PI-3K cascade:FGFR2	6	9.89e-01	-0.003360	9.96e-01
PI-3K cascade:FGFR3	6	9.89e-01	-0.003360	9.96e-01
RNA Polymerase III Transcription Initiation	19	9.80e-01	0.003300	9.90e-01
IRF3-mediated induction of type I IFN	10	9.86e-01	0.003210	9.95e-01
Mitophagy	28	9.77e-01	-0.003140	9.88e-01
Co-stimulation by ICOS	6	9.91e-01	-0.002540	9.96e-01
RND3 GTPase cycle	35	9.81e-01	-0.002280	9.91e-01
Regulation of TP53 Activity through Methylation	10	9.91e-01	-0.002040	9.96e-01
Cargo concentration in the ER	25	9.88e-01	0.001690	9.96e-01
RNA Polymerase III Chain Elongation	10	9.93e-01	0.001680	9.96e-01
Pyrimidine salvage	6	9.95e-01	-0.001510	9.98e-01
Sema4D induced cell migration and growth-cone collapse	15	9.92e-01	-0.001480	9.96e-01
Downregulation of TGF-beta receptor signaling	19	9.93e-01	-0.001200	9.96e-01
Transcriptional Regulation by MECP2	32	9.92e-01	0.001010	9.96e-01
Acyl chain remodelling of PI	5	9.97e-01	0.000982	9.98e-01
Glycerophospholipid biosynthesis	79	9.90e-01	0.000836	9.96e-01
Regulation of BACH1 activity	5	9.98e-01	0.000672	9.98e-01
Endogenous sterols	10	9.98e-01	0.000569	9.98e-01
Attachment of bacteria to epithelial cells	14	9.98e-01	-0.000443	9.98e-01
Biofilm formation	14	9.98e-01	-0.000443	9.98e-01

---

Detailed Gene set reports

rRNA modification in the mitochondrion

set	rRNA modification in the mitochondrion
setSize	13
pANOVA	8.24e-08
s.dist	0.859
p.adjustANOVA	1.72e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTERF4	3582
MRM2	3411
MRM3	3340
RPUSD3	3327
MRM1	3243
RCC1L	3213
MTERF3	3078
RPUSD4	3047
NGRN	3022
FASTKD2	2976
TRUB2	2907
NSUN4	2545
TFB1M	2368

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTERF4	3582
MRM2	3411
MRM3	3340
RPUSD3	3327
MRM1	3243
RCC1L	3213
MTERF3	3078
RPUSD4	3047
NGRN	3022
FASTKD2	2976
TRUB2	2907
NSUN4	2545
TFB1M	2368

---

Mitochondrial ribosome-associated quality control

set	Mitochondrial ribosome-associated quality control
setSize	89
pANOVA	1.48e-41
s.dist	0.826
p.adjustANOVA	2.61e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404
MRPL41	3385
MRPL14	3379
MRPL32	3373
MRPL21	3371
MRPL38	3369
MRPL37	3354
ERAL1	3348
MRPL49	3341
GADD45GIP1	3333
MRPL33	3303
MRPL28	3299
MRPL2	3298
MRPL15	3297
MRPS6	3283
MRPL13	3281
MALSU1	3280
MRPL24	3266
MRPL50	3265
MRPL40	3259
MRPL47	3246
MRPL20	3244
MRPL18	3238
MRPL4	3195
NDUFAB1	3193
MRPL27	3188
MRPL58	3182
KGD4	3158
MRPS25	3082
MRPL52	3067
MRPS18A	3055
MRPS34	3046
MRPS17	3039
MRPL51	3023
MRPS2	3008
MRPL46	3007
MRPL57	2981
MRPL30	2903
MRPS26	2897
MRPS27	2872
MRPL42	2861
MRPS22	2835
MRPL34	2790
MIEF1	2761
MRPS18B	2748
MTRES1	2740
MRPS16	2713
MRPL43	2648
MRPL35	2626
OXA1L	2599
MRPS9	2577
MRPS23	2508
MRPS28	2332
MRPS18C	2301
MRPS31	2214
DAP3	2200
AURKAIP1	2163
MRPS10	2110
MRPS7	2091
MRPS35	2060
MRPS11	2052
MRPS15	1960
MRPS24	1953
MRPS12	1943
MRPS21	1937
PTCD3	1907
CHCHD1	1675
MRPS5	1468
MRPS14	1265
MRPS33	337

---

RUNX2 regulates genes involved in cell migration

set	RUNX2 regulates genes involved in cell migration
setSize	5
pANOVA	0.00176
s.dist	-0.808
p.adjustANOVA	0.00999

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKT3	-3977
ITGA5	-3772
AKT1	-3331
AKT2	-2950
CBFB	-2788

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All member genes

GeneID	Gene Rank
AKT3	-3977
ITGA5	-3772
AKT1	-3331
AKT2	-2950
CBFB	-2788

---

Classical antibody-mediated complement activation

set	Classical antibody-mediated complement activation
setSize	6
pANOVA	0.000692
s.dist	0.8
p.adjustANOVA	0.00434

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLC2	3563
C1QC	3389
IGHG2	2963
IGHG1	2606
IGHV3-7	2367
IGKV4-1	2254

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLC2	3563
C1QC	3389
IGHG2	2963
IGHG1	2606
IGHV3-7	2367
IGKV4-1	2254

---

Creation of C4 and C2 activators

set	Creation of C4 and C2 activators
setSize	6
pANOVA	0.000692
s.dist	0.8
p.adjustANOVA	0.00434

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLC2	3563
C1QC	3389
IGHG2	2963
IGHG1	2606
IGHV3-7	2367
IGKV4-1	2254

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLC2	3563
C1QC	3389
IGHG2	2963
IGHG1	2606
IGHV3-7	2367
IGKV4-1	2254

---

Initial triggering of complement

set	Initial triggering of complement
setSize	9
pANOVA	6.95e-05
s.dist	0.766
p.adjustANOVA	0.000657

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLC2	3563
C1QC	3389
IGHG2	2963
C3	2849
CFB	2645
IGHG1	2606
IGHV3-7	2367
IGKV4-1	2254
C4B	1879

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLC2	3563
C1QC	3389
IGHG2	2963
C3	2849
CFB	2645
IGHG1	2606
IGHV3-7	2367
IGKV4-1	2254
C4B	1879

---

Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

set	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
setSize	29
pANOVA	1.12e-12
s.dist	0.763
p.adjustANOVA	7.53e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
NUP50	-1541
TPR	-1617

---

IP3 and IP4 transport between cytosol and nucleus

set	IP3 and IP4 transport between cytosol and nucleus
setSize	29
pANOVA	1.12e-12
s.dist	0.763
p.adjustANOVA	7.53e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
NUP50	-1541
TPR	-1617

---

IP6 and IP7 transport between cytosol and nucleus

set	IP6 and IP7 transport between cytosol and nucleus
setSize	29
pANOVA	1.12e-12
s.dist	0.763
p.adjustANOVA	7.53e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
NUP50	-1541
TPR	-1617

---

IPs transport between nucleus and cytosol

set	IPs transport between nucleus and cytosol
setSize	29
pANOVA	1.12e-12
s.dist	0.763
p.adjustANOVA	7.53e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
NUP50	-1541
TPR	-1617

---

Regulation of Glucokinase by Glucokinase Regulatory Protein

set	Regulation of Glucokinase by Glucokinase Regulatory Protein
setSize	29
pANOVA	1.12e-12
s.dist	0.763
p.adjustANOVA	7.53e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
NUP50	-1541
TPR	-1617

---

PDH complex synthesizes acetyl-CoA from PYR

set	PDH complex synthesizes acetyl-CoA from PYR
setSize	5
pANOVA	0.00423
s.dist	0.739
p.adjustANOVA	0.0207

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDHA1	2855
PDHB	2809
DLD	2594
DLAT	2496
PDHX	2350

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDHA1	2855
PDHB	2809
DLD	2594
DLAT	2496
PDHX	2350

---

Regulation of pyruvate dehydrogenase (PDH) complex

set	Regulation of pyruvate dehydrogenase (PDH) complex
setSize	12
pANOVA	1.19e-05
s.dist	0.73
p.adjustANOVA	0.000154

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDK2	3530
PDK1	3492
GSTZ1	3001
PDHA1	2855
PDHB	2809
DLD	2594
DLAT	2496
PDHX	2350
PDPR	2310
PDP1	1962
PDP2	1894
PDK3	1733

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDK2	3530
PDK1	3492
GSTZ1	3001
PDHA1	2855
PDHB	2809
DLD	2594
DLAT	2496
PDHX	2350
PDPR	2310
PDP1	1962
PDP2	1894
PDK3	1733

---

SUMOylation of SUMOylation proteins

set	SUMOylation of SUMOylation proteins
setSize	31
pANOVA	3.77e-12
s.dist	0.721
p.adjustANOVA	2.21e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
UBE2I	628
NUP153	373
SUMO2	-323
NUP50	-1541
TPR	-1617

---

RSK activation

set	RSK activation
setSize	5
pANOVA	0.0054
s.dist	-0.719
p.adjustANOVA	0.0256

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK3	-3871
RPS6KA1	-3827
RPS6KA3	-3731
MAPK1	-2469
PDPK1	-1195

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK3	-3871
RPS6KA1	-3827
RPS6KA3	-3731
MAPK1	-2469
PDPK1	-1195

---

Ketone body metabolism

set	Ketone body metabolism
setSize	7
pANOVA	0.00107
s.dist	0.714
p.adjustANOVA	0.00631

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDH2	3600
BDH1	3289
ACAT1	3054
HMGCL	2785
OXCT1	2589
ACSS3	2363
AACS	-8

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDH2	3600
BDH1	3289
ACAT1	3054
HMGCL	2785
OXCT1	2589
ACSS3	2363
AACS	-8

---

Propionyl-CoA catabolism

set	Propionyl-CoA catabolism
setSize	5
pANOVA	0.00585
s.dist	0.712
p.adjustANOVA	0.0275

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MMAA	3402
MMUT	2559
MCEE	2235
PCCA	2234
PCCB	2153

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MMAA	3402
MMUT	2559
MCEE	2235
PCCA	2234
PCCB	2153

---

Synthesis of Ketone Bodies

set	Synthesis of Ketone Bodies
setSize	6
pANOVA	0.00256
s.dist	0.711
p.adjustANOVA	0.0137

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDH2	3600
BDH1	3289
ACAT1	3054
HMGCL	2785
ACSS3	2363
AACS	-8

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDH2	3600
BDH1	3289
ACAT1	3054
HMGCL	2785
ACSS3	2363
AACS	-8

---

Diseases of branched-chain amino acid catabolism

set	Diseases of branched-chain amino acid catabolism
setSize	12
pANOVA	2.44e-05
s.dist	0.704
p.adjustANOVA	0.000286

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCCC2	3399
HIBCH	3362
BCKDK	3351
AUH	3315
ACAT1	3054
MCCC1	2789
DLD	2594
BCKDHA	2242
BCKDHB	2170
DBT	1478
ECHS1	1402
IVD	635

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCCC2	3399
HIBCH	3362
BCKDK	3351
AUH	3315
ACAT1	3054
MCCC1	2789
DLD	2594
BCKDHA	2242
BCKDHB	2170
DBT	1478
ECHS1	1402
IVD	635

---

Mitochondrial iron-sulfur cluster biogenesis

set	Mitochondrial iron-sulfur cluster biogenesis
setSize	13
pANOVA	1.16e-05
s.dist	0.702
p.adjustANOVA	0.000153

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LYRM4	3089
ISCA1	2958
NFS1	2808
ISCU	2797
FXN	2694
HSCB	2685
SLC25A37	2546
FDX1	2533
GLRX5	2419
FDX2	2259
ISCA2	2126
SLC25A28	1911
FDXR	1387

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LYRM4	3089
ISCA1	2958
NFS1	2808
ISCU	2797
FXN	2694
HSCB	2685
SLC25A37	2546
FDX1	2533
GLRX5	2419
FDX2	2259
ISCA2	2126
SLC25A28	1911
FDXR	1387

---

NEP/NS2 Interacts with the Cellular Export Machinery

set	NEP/NS2 Interacts with the Cellular Export Machinery
setSize	31
pANOVA	1.62e-11
s.dist	0.699
p.adjustANOVA	7.49e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
RAN	344
NUP50	-1541
TPR	-1617
XPO1	-2621

---

Protein lipoylation

set	Protein lipoylation
setSize	9
pANOVA	0.000303
s.dist	0.696
p.adjustANOVA	0.00222

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LIAS	3326
NDUFAB1	3193
LIPT1	2679
FDX1	2533
DLAT	2496
GCSH	2317
DLST	2275
NFU1	1773
DBT	1478

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LIAS	3326
NDUFAB1	3193
LIPT1	2679
FDX1	2533
DLAT	2496
GCSH	2317
DLST	2275
NFU1	1773
DBT	1478

---

Mitochondrial translation

set	Mitochondrial translation
setSize	111
pANOVA	1.01e-36
s.dist	0.695
p.adjustANOVA	8.86e-34

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRRF	3516
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRRF	3516
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404
MRPL41	3385
MRPL14	3379
MRPL32	3373
MRPL21	3371
MRPL38	3369
MRPL37	3354
ERAL1	3348
MRPL49	3341
GADD45GIP1	3333
MRPL33	3303
MRPL28	3299
MRPL2	3298
MRPL15	3297
MRPS6	3283
MRPL13	3281
MALSU1	3280
MRPL24	3266
MRPL50	3265
MRPL40	3259
MRPL47	3246
MRPL20	3244
MRPL18	3238
MRPL4	3195
NDUFAB1	3193
MTRF1	3191
MRPL27	3188
MRPL58	3182
KGD4	3158
MRPS25	3082
MRPL52	3067
MRPS18A	3055
MRPS34	3046
MRPS17	3039
MRPL51	3023
MRPS2	3008
MRPL46	3007
MRPL57	2981
MRPL30	2903
MRPS26	2897
TSFM	2883
MRPS27	2872
MRPL42	2861
MTIF3	2858
MRPS22	2835
MRPL34	2790
MTFMT	2781
TUFM	2778
MIEF1	2761
MRPS18B	2748
MTRES1	2740
MRPS16	2713
MRPL43	2648
MT-ATP6	2638
MRPL35	2626
OXA1L	2599
MRPS9	2577
MRPS23	2508
GFM1	2427
MRPS28	2332
MRPS18C	2301
MRPS31	2214
DAP3	2200
AURKAIP1	2163
MT-ND3	2129
MRPS10	2110
MRPS7	2091
MRPS35	2060
MTIF2	2053
MRPS11	2052
MTRF1L	2011
MRPS15	1960
MRPS24	1953
MRPS12	1943
MRPS21	1937
PTCD3	1907
GFM2	1794
CHCHD1	1675
MT-CYB	1596
MRPS5	1468
MRPS14	1265
MRPS33	337
MT-ND2	-739
MT-ND6	-1670
MT-ND4	-2457
MT-ND1	-2564
MT-CO1	-3074
MT-ATP8	-3256
MT-ND5	-3631
MT-CO2	-3750
MT-CO3	-3775

---

Vpr-mediated nuclear import of PICs

set	Vpr-mediated nuclear import of PICs
setSize	33
pANOVA	5.61e-12
s.dist	0.693
p.adjustANOVA	2.99e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
BANF1	3556
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
BANF1	3556
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
PSIP1	1337
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
HMGA1	-236
NUP50	-1541
TPR	-1617
KPNA1	-2821

---

SUMOylation of ubiquitinylation proteins

set	SUMOylation of ubiquitinylation proteins
setSize	33
pANOVA	9.15e-12
s.dist	0.686
p.adjustANOVA	4.59e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
TRIM27	1666
AAAS	1336
NDC1	1281
POM121C	1266
UBE2I	628
NUP153	373
PIAS1	-163
PML	-1187
NUP50	-1541
TPR	-1617

---

Mitochondrial translation termination

set	Mitochondrial translation termination
setSize	101
pANOVA	1.22e-32
s.dist	0.685
p.adjustANOVA	7.14e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRRF	3516
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRRF	3516
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404
MRPL41	3385
MRPL14	3379
MRPL32	3373
MRPL21	3371
MRPL38	3369
MRPL37	3354
ERAL1	3348
MRPL49	3341
GADD45GIP1	3333
MRPL33	3303
MRPL28	3299
MRPL2	3298
MRPL15	3297
MRPS6	3283
MRPL13	3281
MRPL24	3266
MRPL50	3265
MRPL40	3259
MRPL47	3246
MRPL20	3244
MRPL18	3238
MRPL4	3195
MTRF1	3191
MRPL27	3188
MRPL58	3182
KGD4	3158
MRPS25	3082
MRPL52	3067
MRPS18A	3055
MRPS34	3046
MRPS17	3039
MRPL51	3023
MRPS2	3008
MRPL46	3007
MRPL57	2981
MRPL30	2903
MRPS26	2897
MRPS27	2872
MRPL42	2861
MRPS22	2835
MRPL34	2790
MRPS18B	2748
MRPS16	2713
MRPL43	2648
MT-ATP6	2638
MRPL35	2626
OXA1L	2599
MRPS9	2577
MRPS23	2508
MRPS28	2332
MRPS18C	2301
MRPS31	2214
DAP3	2200
AURKAIP1	2163
MT-ND3	2129
MRPS10	2110
MRPS7	2091
MRPS35	2060
MRPS11	2052
MTRF1L	2011
MRPS15	1960
MRPS24	1953
MRPS12	1943
MRPS21	1937
PTCD3	1907
GFM2	1794
CHCHD1	1675
MT-CYB	1596
MRPS5	1468
MRPS14	1265
MRPS33	337
MT-ND2	-739
MT-ND6	-1670
MT-ND4	-2457
MT-ND1	-2564
MT-CO1	-3074
MT-ATP8	-3256
MT-ND5	-3631
MT-CO2	-3750
MT-CO3	-3775

---

Mitochondrial translation elongation

set	Mitochondrial translation elongation
setSize	100
pANOVA	2.57e-32
s.dist	0.685
p.adjustANOVA	1.12e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404
MRPL41	3385
MRPL14	3379
MRPL32	3373
MRPL21	3371
MRPL38	3369
MRPL37	3354
ERAL1	3348
MRPL49	3341
GADD45GIP1	3333
MRPL33	3303
MRPL28	3299
MRPL2	3298
MRPL15	3297
MRPS6	3283
MRPL13	3281
MRPL24	3266
MRPL50	3265
MRPL40	3259
MRPL47	3246
MRPL20	3244
MRPL18	3238
MRPL4	3195
MRPL27	3188
MRPL58	3182
KGD4	3158
MRPS25	3082
MRPL52	3067
MRPS18A	3055
MRPS34	3046
MRPS17	3039
MRPL51	3023
MRPS2	3008
MRPL46	3007
MRPL57	2981
MRPL30	2903
MRPS26	2897
TSFM	2883
MRPS27	2872
MRPL42	2861
MRPS22	2835
MRPL34	2790
TUFM	2778
MRPS18B	2748
MRPS16	2713
MRPL43	2648
MT-ATP6	2638
MRPL35	2626
OXA1L	2599
MRPS9	2577
MRPS23	2508
GFM1	2427
MRPS28	2332
MRPS18C	2301
MRPS31	2214
DAP3	2200
AURKAIP1	2163
MT-ND3	2129
MRPS10	2110
MRPS7	2091
MRPS35	2060
MRPS11	2052
MRPS15	1960
MRPS24	1953
MRPS12	1943
MRPS21	1937
PTCD3	1907
CHCHD1	1675
MT-CYB	1596
MRPS5	1468
MRPS14	1265
MRPS33	337
MT-ND2	-739
MT-ND6	-1670
MT-ND4	-2457
MT-ND1	-2564
MT-CO1	-3074
MT-ATP8	-3256
MT-ND5	-3631
MT-CO2	-3750
MT-CO3	-3775

---

Maturation of TCA enzymes and regulation of TCA cycle

set	Maturation of TCA enzymes and regulation of TCA cycle
setSize	19
pANOVA	2.41e-07
s.dist	0.684
p.adjustANOVA	4.6e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SDHAF2	3487
ACO2	3241
SDHA	3134
LYRM4	3089
ACAT1	3054
SIRT3	3050
ISCA1	2958
NFS1	2808
ISCU	2797
SDHB	2702
FXN	2694
SDHAF1	2613
CS	2569
ISCA2	2126
SDHAF4	1555
SDHC	1344
IDH2	1295
SDHD	788
SDHAF3	408

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SDHAF2	3487
ACO2	3241
SDHA	3134
LYRM4	3089
ACAT1	3054
SIRT3	3050
ISCA1	2958
NFS1	2808
ISCU	2797
SDHB	2702
FXN	2694
SDHAF1	2613
CS	2569
ISCA2	2126
SDHAF4	1555
SDHC	1344
IDH2	1295
SDHD	788
SDHAF3	408

---

Mitochondrial translation initiation

set	Mitochondrial translation initiation
setSize	100
pANOVA	3.19e-32
s.dist	0.684
p.adjustANOVA	1.12e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL36	3623
MRPL12	3567
MRPL54	3528
MRPL11	3504
MRPL10	3501
MRPL48	3490
MRPS30	3478
MRPL1	3468
MRPL22	3467
MRPL45	3463
MRPL23	3460
MRPL44	3435
MRPL39	3430
MRPL16	3426
MRPL9	3421
MRPL55	3418
MRPL53	3412
MRPL19	3409
MRPL17	3405
MRPL3	3404
MRPL41	3385
MRPL14	3379
MRPL32	3373
MRPL21	3371
MRPL38	3369
MRPL37	3354
ERAL1	3348
MRPL49	3341
GADD45GIP1	3333
MRPL33	3303
MRPL28	3299
MRPL2	3298
MRPL15	3297
MRPS6	3283
MRPL13	3281
MRPL24	3266
MRPL50	3265
MRPL40	3259
MRPL47	3246
MRPL20	3244
MRPL18	3238
MRPL4	3195
MRPL27	3188
MRPL58	3182
KGD4	3158
MRPS25	3082
MRPL52	3067
MRPS18A	3055
MRPS34	3046
MRPS17	3039
MRPL51	3023
MRPS2	3008
MRPL46	3007
MRPL57	2981
MRPL30	2903
MRPS26	2897
MRPS27	2872
MRPL42	2861
MTIF3	2858
MRPS22	2835
MRPL34	2790
MTFMT	2781
MRPS18B	2748
MRPS16	2713
MRPL43	2648
MT-ATP6	2638
MRPL35	2626
OXA1L	2599
MRPS9	2577
MRPS23	2508
MRPS28	2332
MRPS18C	2301
MRPS31	2214
DAP3	2200
AURKAIP1	2163
MT-ND3	2129
MRPS10	2110
MRPS7	2091
MRPS35	2060
MTIF2	2053
MRPS11	2052
MRPS15	1960
MRPS24	1953
MRPS12	1943
MRPS21	1937
PTCD3	1907
CHCHD1	1675
MT-CYB	1596
MRPS5	1468
MRPS14	1265
MRPS33	337
MT-ND2	-739
MT-ND6	-1670
MT-ND4	-2457
MT-ND1	-2564
MT-CO1	-3074
MT-ATP8	-3256
MT-ND5	-3631
MT-CO2	-3750
MT-CO3	-3775

---

Beta-oxidation of pristanoyl-CoA

set	Beta-oxidation of pristanoyl-CoA
setSize	6
pANOVA	0.0038
s.dist	0.682
p.adjustANOVA	0.0193

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AMACR	3328
ACOX3	2700
ACOT8	2571
HSD17B4	2557
CRAT	2463
SCP2	797

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AMACR	3328
ACOX3	2700
ACOT8	2571
HSD17B4	2557
CRAT	2463
SCP2	797

---

Postmitotic nuclear pore complex (NPC) reformation

set	Postmitotic nuclear pore complex (NPC) reformation
setSize	25
pANOVA	4.33e-09
s.dist	0.678
p.adjustANOVA	1.17e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP188	3593
NUP37	3575
NUP98	3568
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP93	2750
AHCTF1	1634
NDC1	1281
UBE2I	628

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP188	3593
NUP37	3575
NUP98	3568
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP93	2750
AHCTF1	1634
NDC1	1281
UBE2I	628
RCC1	596
RAN	344
RANGAP1	-128
TNPO1	-819
KPNB1	-2031

---

Transport of Ribonucleoproteins into the Host Nucleus

set	Transport of Ribonucleoproteins into the Host Nucleus
setSize	31
pANOVA	6.64e-11
s.dist	0.678
p.adjustANOVA	2.48e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
NUP50	-1541
TPR	-1617
KPNB1	-2031
KPNA1	-2821

---

Diseases of hemostasis

set	Diseases of hemostasis
setSize	5
pANOVA	0.00872
s.dist	0.677
p.adjustANOVA	0.0389

Top enriched genes

Top 20 genes

GeneID	Gene Rank
F2	3099
COL1A1	3037
TPST1	2982
GGCX	2032
TPST2	767

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
F2	3099
COL1A1	3037
TPST1	2982
GGCX	2032
TPST2	767

---

Nef mediated downregulation of MHC class I complex cell surface expression

set	Nef mediated downregulation of MHC class I complex cell surface expression
setSize	9
pANOVA	0.000446
s.dist	-0.676
p.adjustANOVA	0.00303

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP1G1	-3846
AP1S1	-3763
AP1M1	-3671
AP1S3	-3594
AP1S2	-2796
PACS1	-2660
HLA-A	-2540
B2M	-1777
AP1B1	-1029

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP1G1	-3846
AP1S1	-3763
AP1M1	-3671
AP1S3	-3594
AP1S2	-2796
PACS1	-2660
HLA-A	-2540
B2M	-1777
AP1B1	-1029

---

Branched-chain ketoacid dehydrogenase kinase deficiency

set	Branched-chain ketoacid dehydrogenase kinase deficiency
setSize	5
pANOVA	0.00915
s.dist	0.673
p.adjustANOVA	0.0403

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BCKDK	3351
DLD	2594
BCKDHA	2242
BCKDHB	2170
DBT	1478

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BCKDK	3351
DLD	2594
BCKDHA	2242
BCKDHB	2170
DBT	1478

---

Negative feedback regulation of MAPK pathway

set	Negative feedback regulation of MAPK pathway
setSize	5
pANOVA	0.00939
s.dist	-0.671
p.adjustANOVA	0.0411

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAP2K1	-3986
MAPK3	-3871
MAP2K2	-2940
MAPK1	-2469
RAF1	-905

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAP2K1	-3986
MAPK3	-3871
MAP2K2	-2940
MAPK1	-2469
RAF1	-905

---

Citric acid cycle (TCA cycle)

set	Citric acid cycle (TCA cycle)
setSize	33
pANOVA	3.74e-11
s.dist	0.665
p.adjustANOVA	1.49e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SDHAF2	3487
NNT	3425
ACO2	3241
KGD4	3158
SDHA	3134
LYRM4	3089
SUCLG1	3060
ACAT1	3054
SIRT3	3050
ISCA1	2958
NFS1	2808
ISCU	2797
SDHB	2702
FXN	2694
SDHAF1	2613
DLD	2594
SUCLA2	2573
CS	2569
SUCLG2	2534
MDH2	2454

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SDHAF2	3487
NNT	3425
ACO2	3241
KGD4	3158
SDHA	3134
LYRM4	3089
SUCLG1	3060
ACAT1	3054
SIRT3	3050
ISCA1	2958
NFS1	2808
ISCU	2797
SDHB	2702
FXN	2694
SDHAF1	2613
DLD	2594
SUCLA2	2573
CS	2569
SUCLG2	2534
MDH2	2454
DLST	2275
TRAP1	2245
ISCA2	2126
OGDH	2125
FH	1954
SDHAF4	1555
IDH3B	1381
SDHC	1344
IDH2	1295
IDH3G	1030
SDHD	788
SDHAF3	408
IDH3A	287

---

Ubiquinol biosynthesis

set	Ubiquinol biosynthesis
setSize	12
pANOVA	7.6e-05
s.dist	0.66
p.adjustANOVA	0.000703

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COQ8A	3142
COQ7	3129
COQ2	2960
COQ5	2590
COQ9	2553
COQ6	2542
HPDL	2335
COQ8B	2240
COQ3	1869
PDSS1	1642
PDSS2	1384
STARD7	1368

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COQ8A	3142
COQ7	3129
COQ2	2960
COQ5	2590
COQ9	2553
COQ6	2542
HPDL	2335
COQ8B	2240
COQ3	1869
PDSS1	1642
PDSS2	1384
STARD7	1368

---

Mitochondrial tRNA aminoacylation

set	Mitochondrial tRNA aminoacylation
setSize	21
pANOVA	1.67e-07
s.dist	0.66
p.adjustANOVA	3.3e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MARS2	3538
HARS2	3515
EARS2	3339
LARS2	3330
WARS2	3061
FARS2	3033
PARS2	2904
YARS2	2889
TARS2	2836
SARS2	2691
RARS2	2591
AARS2	2551
VARS2	2354
CARS2	2265
NARS2	2239
PPA2	1904
IARS2	1284
KARS1	773
DARS2	597
QARS1	495

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MARS2	3538
HARS2	3515
EARS2	3339
LARS2	3330
WARS2	3061
FARS2	3033
PARS2	2904
YARS2	2889
TARS2	2836
SARS2	2691
RARS2	2591
AARS2	2551
VARS2	2354
CARS2	2265
NARS2	2239
PPA2	1904
IARS2	1284
KARS1	773
DARS2	597
QARS1	495
GARS1	315

---

Nuclear import of Rev protein

set	Nuclear import of Rev protein
setSize	33
pANOVA	5.71e-11
s.dist	0.659
p.adjustANOVA	2.18e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
RCC1	596
NUP153	373
RAN	344
NPM1	-1387
NUP50	-1541
TPR	-1617
KPNB1	-2031

---

Export of Viral Ribonucleoproteins from Nucleus

set	Export of Viral Ribonucleoproteins from Nucleus
setSize	32
pANOVA	1.17e-10
s.dist	0.658
p.adjustANOVA	4.2e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
RAN	344
NUP50	-1541
TPR	-1617
HSPA1A	-2600
XPO1	-2621

---

Transport of the SLBP Dependant Mature mRNA

set	Transport of the SLBP Dependant Mature mRNA
setSize	34
pANOVA	3.34e-11
s.dist	0.657
p.adjustANOVA	1.44e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
NXF1	2420
AAAS	1336
NDC1	1281
POM121C	1266
NCBP2	456
NUP153	373
NCBP1	-675
ALYREF	-938
NUP50	-1541
TPR	-1617
EIF4E	-1695

---

Transport of the SLBP independent Mature mRNA

set	Transport of the SLBP independent Mature mRNA
setSize	34
pANOVA	3.34e-11
s.dist	0.657
p.adjustANOVA	1.44e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
NXF1	2420
AAAS	1336
NDC1	1281
POM121C	1266
NCBP2	456
NUP153	373
NCBP1	-675
ALYREF	-938
NUP50	-1541
TPR	-1617
EIF4E	-1695

---

Rev-mediated nuclear export of HIV RNA

set	Rev-mediated nuclear export of HIV RNA
setSize	34
pANOVA	5.29e-11
s.dist	0.65
p.adjustANOVA	2.07e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
RANBP2	2423
AAAS	1336
NDC1	1281
POM121C	1266
RCC1	596
RANBP1	494
NUP153	373
RAN	344
RANGAP1	-128
NUP50	-1541
TPR	-1617
XPO1	-2621

---

Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

set	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
setSize	5
pANOVA	0.0134
s.dist	-0.639
p.adjustANOVA	0.0545

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NOTCH1	-3681
ADAM10	-3438
ADAM17	-3381
JAG1	-1621
JAG2	-1428

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NOTCH1	-3681
ADAM10	-3438
ADAM17	-3381
JAG1	-1621
JAG2	-1428

---

Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

set	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
setSize	5
pANOVA	0.0134
s.dist	-0.639
p.adjustANOVA	0.0545

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NOTCH1	-3681
ADAM10	-3438
ADAM17	-3381
JAG1	-1621
JAG2	-1428

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NOTCH1	-3681
ADAM10	-3438
ADAM17	-3381
JAG1	-1621
JAG2	-1428

---

Interactions of Vpr with host cellular proteins

set	Interactions of Vpr with host cellular proteins
setSize	36
pANOVA	3.35e-11
s.dist	0.639
p.adjustANOVA	1.44e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
BANF1	3556
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP35	3625
NUP62	3608
NUP43	3606
NUP85	3603
NUP42	3599
NUP188	3593
NUP37	3575
NUP98	3568
NUP88	3559
BANF1	3556
RAE1	3513
NUP160	3505
SEH1L	3443
NUP133	3437
NUP107	3366
NUP205	3365
NUP214	3343
SEC13	3334
NUP58	3295
NUP54	3181
NUP155	3154
NUP210	2940
NUP93	2750
SLC25A4	2719
RANBP2	2423
PSIP1	1337
AAAS	1336
NDC1	1281
POM121C	1266
NUP153	373
HMGA1	-236
SLC25A5	-506
NUP50	-1541
TPR	-1617
SLC25A6	-2476
KPNA1	-2821

---

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

set	Negative regulation of TCF-dependent signaling by WNT ligand antagonists
setSize	5
pANOVA	0.0136
s.dist	0.637
p.adjustANOVA	0.0551

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DKK1	3483
LRP6	2299
LRP5	2095
SFRP1	1839
WNT5A	1429

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DKK1	3483
LRP6	2299
LRP5	2095
SFRP1	1839
WNT5A	1429

---

Mucopolysaccharidoses

set	Mucopolysaccharidoses
setSize	9
pANOVA	0.000937
s.dist	0.637
p.adjustANOVA	0.00566

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HGSNAT	3398
NAGLU	3274
GUSB	2735
GLB1	2731
GNS	2375
IDUA	2020
ARSB	1718
SGSH	1695
GALNS	88

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HGSNAT	3398
NAGLU	3274
GUSB	2735
GLB1	2731
GNS	2375
IDUA	2020
ARSB	1718
SGSH	1695
GALNS	88

---

Strand-asynchronous mitochondrial DNA replication

set	Strand-asynchronous mitochondrial DNA replication
setSize	10
pANOVA	0.000497
s.dist	0.636
p.adjustANOVA	0.00329

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLG2	3277
TOP3A	3207
MGME1	3106
POLRMT	2954
SSBP1	2675
RNASEH1	2445
POLG	2359
TWNK	2171
EXOG	626
LIG3	-602

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLG2	3277
TOP3A	3207
MGME1	3106
POLRMT	2954
SSBP1	2675
RNASEH1	2445
POLG	2359
TWNK	2171
EXOG	626
LIG3	-602

---

Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Classical antibody-mediated complement activation`
## [1] "C1QC"  "IGLC2"
## 
## [[1]]$`UP genesets.Creation of C4 and C2 activators`
## [1] "C1QC"  "IGLC2"
## 
## [[1]]$`UP genesets.Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.Diseases of branched-chain amino acid catabolism`
## [1] "AUH"   "BCKDK" "HIBCH" "MCCC2"
## 
## [[1]]$`UP genesets.IP3 and IP4 transport between cytosol and nucleus`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.IP6 and IP7 transport between cytosol and nucleus`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.IPs transport between nucleus and cytosol`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.Initial triggering of complement`
## [1] "C1QC"  "IGLC2"
## 
## [[1]]$`UP genesets.Ketone body metabolism`
## [1] "BDH1" "BDH2"
## 
## [[1]]$`UP genesets.Mitochondrial iron-sulfur cluster biogenesis`
## character(0)
## 
## [[1]]$`UP genesets.Mitochondrial ribosome-associated quality control`
##  [1] "ERAL1"      "GADD45GIP1" "MALSU1"     "MRPL1"      "MRPL10"    
##  [6] "MRPL11"     "MRPL12"     "MRPL13"     "MRPL14"     "MRPL15"    
## [11] "MRPL16"     "MRPL17"     "MRPL19"     "MRPL2"      "MRPL21"    
## [16] "MRPL22"     "MRPL23"     "MRPL24"     "MRPL28"     "MRPL3"     
## [21] "MRPL32"     "MRPL33"     "MRPL36"     "MRPL37"     "MRPL38"    
## [26] "MRPL39"     "MRPL40"     "MRPL41"     "MRPL44"     "MRPL45"    
## [31] "MRPL48"     "MRPL49"     "MRPL50"     "MRPL53"     "MRPL54"    
## [36] "MRPL55"     "MRPL9"      "MRPS30"     "MRPS6"     
## 
## [[1]]$`UP genesets.NEP/NS2 Interacts with the Cellular Export Machinery`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.PDH complex synthesizes acetyl-CoA from PYR`
## character(0)
## 
## [[1]]$`UP genesets.Propionyl-CoA catabolism`
## [1] "MMAA"
## 
## [[1]]$`UP genesets.Protein lipoylation`
## [1] "LIAS"
## 
## [[1]]$`UP genesets.Regulation of Glucokinase by Glucokinase Regulatory Protein`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.Regulation of pyruvate dehydrogenase (PDH) complex`
## [1] "PDK1" "PDK2"
## 
## [[1]]$`UP genesets.SUMOylation of SUMOylation proteins`
##  [1] "NUP107" "NUP133" "NUP160" "NUP188" "NUP205" "NUP214" "NUP35"  "NUP37" 
##  [9] "NUP42"  "NUP43"  "NUP58"  "NUP62"  "NUP85"  "NUP88"  "NUP98"  "RAE1"  
## [17] "SEC13"  "SEH1L" 
## 
## [[1]]$`UP genesets.Synthesis of Ketone Bodies`
## [1] "BDH1" "BDH2"
## 
## [[1]]$`UP genesets.rRNA modification in the mitochondrion`
## [1] "MRM2"   "MRM3"   "MTERF4" "RPUSD3"
## 
## [[1]]$`DOWN genesets.Activation of caspases through apoptosome-mediated cleavage`
## [1] "APAF1" "CASP3" "CASP7" "CASP9" "CYCS"  "XIAP" 
## 
## [[1]]$`DOWN genesets.Caspase-mediated cleavage of cytoskeletal proteins`
##  [1] "ADD1"   "CASP3"  "CASP6"  "CASP7"  "CASP8"  "DBNL"   "GSN"    "PLEC"  
##  [9] "SPTAN1" "VIM"   
## 
## [[1]]$`DOWN genesets.DNA Damage Reversal`
## [1] "ALKBH2" "ALKBH5" "ASCC1"  "ASCC2"  "ASCC3"  "FTO"   
## 
## [[1]]$`DOWN genesets.Formation of tubulin folding intermediates by CCT/TriC`
##  [1] "CCT2"   "CCT3"   "CCT4"   "CCT5"   "CCT6A"  "CCT6B"  "CCT7"   "CCT8"  
##  [9] "TCP1"   "TUBA1C" "TUBA3C" "TUBA4A" "TUBA8"  "TUBAL3" "TUBB2A" "TUBB2B"
## [17] "TUBB3"  "TUBB4A" "TUBB4B" "TUBB6" 
## 
## [[1]]$`DOWN genesets.Frs2-mediated activation`
## [1] "CRKL"   "FRS2"   "MAP2K1" "MAP2K2" "MAPK1"  "MAPK3"  "RAP1A"  "YWHAB" 
## 
## [[1]]$`DOWN genesets.G beta:gamma signalling through PI3Kgamma`
##  [1] "AKT1"  "AKT2"  "AKT3"  "GNB1"  "GNB2"  "GNB4"  "GNG12" "GNG2"  "GNG4" 
## [10] "PDPK1" "RHOA" 
## 
## [[1]]$`DOWN genesets.Glucagon-type ligand receptors`
## [1] "ADCYAP1R1" "GNAS"      "GNB1"      "GNB2"      "GNB4"      "GNG12"    
## [7] "GNG2"      "GNG4"      "VIPR1"    
## 
## [[1]]$`DOWN genesets.Nef mediated downregulation of MHC class I complex cell surface expression`
## [1] "AP1B1" "AP1G1" "AP1M1" "AP1S1" "AP1S2" "AP1S3" "B2M"   "HLA-A" "PACS1"
## 
## [[1]]$`DOWN genesets.Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters`
##  [1] "AP1B1"   "AP1G1"   "AP1M1"   "AP1S1"   "AP1S2"   "AP1S3"   "AP2A1"  
##  [8] "AP2A2"   "AP2B1"   "AP2M1"   "AP2S1"   "ARF1"    "ATP6V1H" "B2M"    
## [15] "HLA-A"   "PACS1"  
## 
## [[1]]$`DOWN genesets.Negative feedback regulation of MAPK pathway`
## [1] "MAP2K1" "MAP2K2" "MAPK1"  "MAPK3"  "RAF1"  
## 
## [[1]]$`DOWN genesets.Prevention of phagosomal-lysosomal fusion`
## [1] "CORO1A" "HGS"    "RAB5A"  "RAB7A"  "RPS27A" "VPS33B"
## 
## [[1]]$`DOWN genesets.Prolonged ERK activation events`
##  [1] "CRK"       "CRKL"      "FRS2"      "KIDINS220" "MAP2K1"    "MAP2K2"   
##  [7] "MAPK1"     "MAPK3"     "RAP1A"     "YWHAB"    
## 
## [[1]]$`DOWN genesets.RSK activation`
## [1] "MAPK1"   "MAPK3"   "PDPK1"   "RPS6KA1" "RPS6KA3"
## 
## [[1]]$`DOWN genesets.RUNX2 regulates genes involved in cell migration`
## [1] "AKT1"  "AKT2"  "AKT3"  "CBFB"  "ITGA5"
## 
## [[1]]$`DOWN genesets.Reversal of alkylation damage by DNA dioxygenases`
## [1] "ALKBH2" "ALKBH5" "ASCC1"  "ASCC2"  "ASCC3"  "FTO"   
## 
## [[1]]$`DOWN genesets.Suppression of phagosomal maturation`
## [1] "ATP6V1H" "CORO1A"  "HGS"     "KPNA1"   "KPNB1"   "RAB5A"   "RAB7A"  
## [8] "RPS27A"  "VPS33B" 
## 
## [[1]]$`DOWN genesets.Synthesis of PIPs at the Golgi membrane`
##  [1] "ARF1"    "ARF3"    "FIG4"    "OCRL"    "PI4K2A"  "PI4K2B"  "PI4KA"  
##  [8] "PI4KB"   "PIK3C2A" "PIK3C3"  "PIK3R4"  "PIKFYVE" "SACM1L"  "VAC14"  
## 
## [[1]]$`DOWN genesets.Synthesis of PIPs at the early endosome membrane`
##  [1] "FIG4"    "INPP4A"  "INPP5F"  "MTM1"    "MTMR10"  "MTMR12"  "MTMR2"  
##  [8] "PI4K2A"  "PI4K2B"  "PIK3C2A" "PIK3C3"  "PIK3R4"  "PIKFYVE" "VAC14"  
## 
## [[1]]$`DOWN genesets.Synthesis of PIPs at the late endosome membrane`
## [1] "FIG4"    "MTM1"    "MTMR2"   "MTMR9"   "PIK3C2A" "PIK3C3"  "PIK3R4" 
## [8] "PIKFYVE" "VAC14"  
## 
## [[1]]$`DOWN genesets.The role of Nef in HIV-1 replication and disease pathogenesis`
##  [1] "AP1B1"   "AP1G1"   "AP1M1"   "AP1S1"   "AP1S2"   "AP1S3"   "AP2A1"  
##  [8] "AP2A2"   "AP2B1"   "AP2M1"   "AP2S1"   "ARF1"    "ATP6V1H" "B2M"    
## [15] "ELMO1"   "FYN"     "HLA-A"   "PACS1"   "PAK2"    "RAC1"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.5.1 (2025-06-13)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
## [1] gtools_3.9.5        mitch_1.20.0        gplots_3.2.0       
## [4] kableExtra_1.4.0    limma_3.64.3        pcaMethods_2.0.0   
## [7] Biobase_2.68.0      BiocGenerics_0.54.0 generics_0.1.4     
## 
## loaded via a namespace (and not attached):
##  [1] beeswarm_0.4.0        gtable_0.3.6          xfun_0.52            
##  [4] bslib_0.9.0           ggplot2_3.5.2         htmlwidgets_1.6.4    
##  [7] caTools_1.18.3        lattice_0.22-7        GGally_2.3.0         
## [10] vctrs_0.6.5           tools_4.5.1           bitops_1.0-9         
## [13] parallel_4.5.1        tibble_3.3.0          pkgconfig_2.0.3      
## [16] KernSmooth_2.23-26    RColorBrewer_1.1-3    S7_0.2.0             
## [19] lifecycle_1.0.4       compiler_4.5.1        farver_2.1.2         
## [22] stringr_1.5.1         textshaping_1.0.1     statmod_1.5.0        
## [25] httpuv_1.6.16         htmltools_0.5.8.1     sass_0.4.10          
## [28] yaml_2.3.10           pillar_1.11.0         later_1.4.2          
## [31] jquerylib_0.1.4       tidyr_1.3.1           MASS_7.3-65          
## [34] cachem_1.1.0          mime_0.13             network_1.19.0       
## [37] ggstats_0.10.0        tidyselect_1.2.1      digest_0.6.37        
## [40] stringi_1.8.7         reshape2_1.4.4        dplyr_1.1.4          
## [43] purrr_1.1.0           fastmap_1.2.0         grid_4.5.1           
## [46] cli_3.6.5             magrittr_2.0.3        dichromat_2.0-0.1    
## [49] withr_3.0.2           scales_1.4.0          promises_1.3.3       
## [52] rmarkdown_2.29        gridExtra_2.3         coda_0.19-4.1        
## [55] shiny_1.11.1          evaluate_1.0.4        knitr_1.50           
## [58] viridisLite_0.4.2     rlang_1.1.6           Rcpp_1.1.0           
## [61] xtable_1.8-4          glue_1.8.0            echarts4r_0.4.5      
## [64] xml2_1.3.8            svglite_2.2.1         rstudioapi_0.17.1    
## [67] jsonlite_2.0.0        plyr_1.8.9            statnet.common_4.12.0
## [70] R6_2.6.1              systemfonts_1.2.3

END of report