Mitch Report

date generated: 2022-08-23

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA  0.7345726
## 7SK       -2.7733284
## A1BG       0.2830631
## A1BG-AS1  -4.1963792
## A1CF      -0.8548135
## A2M       10.9455668

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2512
num_genes_in_profile	27278
duplicated_genes_present	0
num_profile_genes_in_sets	9132
num_profile_genes_not_in_sets	18146

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2512
num_genesets_excluded	1024
num_genesets_included	1488

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 52 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Unwinding of DNA	12	1.01e-05	0.736	6.79e-05
Leading Strand Synthesis	14	2.89e-06	0.722	2.17e-05
Polymerase switching	14	2.89e-06	0.722	2.17e-05
Response to metal ions	10	7.78e-05	0.721	4.52e-04
G1/S-Specific Transcription	29	1.35e-10	0.689	1.79e-09
Condensation of Prometaphase Chromosomes	11	7.92e-05	0.687	4.57e-04
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	2.31e-04	0.672	1.12e-03
Formation of ATP by chemiosmotic coupling	18	9.15e-07	0.668	7.48e-06
SLBP independent Processing of Histone Pre-mRNAs	10	3.22e-04	0.657	1.50e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.69e-04	0.655	8.75e-04
DNA strand elongation	32	1.49e-10	0.654	1.97e-09
Translesion synthesis by REV1	16	9.42e-06	0.640	6.40e-05
Translesion synthesis by POLK	17	5.71e-06	0.635	4.07e-05
Folding of actin by CCT/TriC	10	5.53e-04	0.631	2.45e-03
SCF(Skp2)-mediated degradation of p27/p21	60	4.00e-17	0.627	2.20e-15
The role of GTSE1 in G2/M progression after G2 checkpoint	58	4.32e-16	0.617	1.90e-14
Metabolism of cofactors	19	3.58e-06	0.614	2.65e-05
Regulation of PTEN mRNA translation	12	2.44e-04	-0.612	1.17e-03
Ubiquitin-dependent degradation of Cyclin D	50	9.50e-14	0.608	2.53e-12
Lagging Strand Synthesis	20	2.88e-06	0.604	2.17e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	7.16e-13	0.598	1.50e-11
Removal of the Flap Intermediate	14	1.18e-04	0.594	6.53e-04
Vpu mediated degradation of CD4	50	3.71e-13	0.594	8.30e-12
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	6.87e-04	-0.591	2.97e-03
Negative regulation of NOTCH4 signaling	54	6.48e-14	0.589	1.79e-12
Hh mutants are degraded by ERAD	54	9.03e-14	0.586	2.44e-12
SCF-beta-TrCP mediated degradation of Emi1	53	1.66e-13	0.585	4.05e-12
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	2.10e-13	0.583	4.96e-12
HuR (ELAVL1) binds and stabilizes mRNA	10	1.56e-03	0.578	6.11e-03
Regulation of BACH1 activity	11	9.75e-04	0.574	4.10e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	2.48e-12	0.572	4.45e-11
p53-Independent DNA Damage Response	50	2.48e-12	0.572	4.45e-11
p53-Independent G1/S DNA damage checkpoint	50	2.48e-12	0.572	4.45e-11
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	13	3.63e-04	-0.571	1.68e-03
Signaling by FGFR2 IIIa TM	19	1.82e-05	0.568	1.18e-04
Hedgehog ligand biogenesis	63	7.41e-15	0.566	2.45e-13
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	8.85e-05	0.566	5.01e-04
Purine salvage	12	6.96e-04	0.565	2.99e-03
GLI3 is processed to GLI3R by the proteasome	57	1.58e-13	0.565	3.99e-12
Vif-mediated degradation of APOBEC3G	52	1.92e-12	0.564	3.71e-11
Formation of tubulin folding intermediates by CCT/TriC	23	2.97e-06	0.563	2.22e-05
Hh mutants abrogate ligand secretion	57	2.06e-13	0.562	4.94e-12
Defective CFTR causes cystic fibrosis	58	1.36e-13	0.561	3.48e-12
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	4.62e-04	0.561	2.08e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.22e-06	0.560	9.83e-06
PCNA-Dependent Long Patch Base Excision Repair	21	8.81e-06	0.560	6.02e-05
NIK–>noncanonical NF-kB signaling	57	2.86e-13	0.559	6.54e-12
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	1.34e-03	0.559	5.37e-03
MASTL Facilitates Mitotic Progression	10	2.25e-03	0.558	8.40e-03
Orc1 removal from chromatin	69	1.12e-15	0.557	4.64e-14
Regulation of ornithine decarboxylase (ODC)	49	1.51e-11	0.557	2.37e-10
Degradation of GLI2 by the proteasome	57	3.74e-13	0.556	8.30e-12

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Unwinding of DNA	12	1.01e-05	7.36e-01	6.79e-05
Leading Strand Synthesis	14	2.89e-06	7.22e-01	2.17e-05
Polymerase switching	14	2.89e-06	7.22e-01	2.17e-05
Response to metal ions	10	7.78e-05	7.21e-01	4.52e-04
G1/S-Specific Transcription	29	1.35e-10	6.89e-01	1.79e-09
Condensation of Prometaphase Chromosomes	11	7.92e-05	6.87e-01	4.57e-04
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	2.31e-04	6.72e-01	1.12e-03
Formation of ATP by chemiosmotic coupling	18	9.15e-07	6.68e-01	7.48e-06
SLBP independent Processing of Histone Pre-mRNAs	10	3.22e-04	6.57e-01	1.50e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.69e-04	6.55e-01	8.75e-04
DNA strand elongation	32	1.49e-10	6.54e-01	1.97e-09
Translesion synthesis by REV1	16	9.42e-06	6.40e-01	6.40e-05
Translesion synthesis by POLK	17	5.71e-06	6.35e-01	4.07e-05
Folding of actin by CCT/TriC	10	5.53e-04	6.31e-01	2.45e-03
SCF(Skp2)-mediated degradation of p27/p21	60	4.00e-17	6.27e-01	2.20e-15
The role of GTSE1 in G2/M progression after G2 checkpoint	58	4.32e-16	6.17e-01	1.90e-14
Metabolism of cofactors	19	3.58e-06	6.14e-01	2.65e-05
Regulation of PTEN mRNA translation	12	2.44e-04	-6.12e-01	1.17e-03
Ubiquitin-dependent degradation of Cyclin D	50	9.50e-14	6.08e-01	2.53e-12
Lagging Strand Synthesis	20	2.88e-06	6.04e-01	2.17e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	7.16e-13	5.98e-01	1.50e-11
Removal of the Flap Intermediate	14	1.18e-04	5.94e-01	6.53e-04
Vpu mediated degradation of CD4	50	3.71e-13	5.94e-01	8.30e-12
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	6.87e-04	-5.91e-01	2.97e-03
Negative regulation of NOTCH4 signaling	54	6.48e-14	5.89e-01	1.79e-12
Hh mutants are degraded by ERAD	54	9.03e-14	5.86e-01	2.44e-12
SCF-beta-TrCP mediated degradation of Emi1	53	1.66e-13	5.85e-01	4.05e-12
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	2.10e-13	5.83e-01	4.96e-12
HuR (ELAVL1) binds and stabilizes mRNA	10	1.56e-03	5.78e-01	6.11e-03
Regulation of BACH1 activity	11	9.75e-04	5.74e-01	4.10e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	2.48e-12	5.72e-01	4.45e-11
p53-Independent DNA Damage Response	50	2.48e-12	5.72e-01	4.45e-11
p53-Independent G1/S DNA damage checkpoint	50	2.48e-12	5.72e-01	4.45e-11
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	13	3.63e-04	-5.71e-01	1.68e-03
Signaling by FGFR2 IIIa TM	19	1.82e-05	5.68e-01	1.18e-04
Hedgehog ligand biogenesis	63	7.41e-15	5.66e-01	2.45e-13
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	8.85e-05	5.66e-01	5.01e-04
Purine salvage	12	6.96e-04	5.65e-01	2.99e-03
GLI3 is processed to GLI3R by the proteasome	57	1.58e-13	5.65e-01	3.99e-12
Vif-mediated degradation of APOBEC3G	52	1.92e-12	5.64e-01	3.71e-11
Formation of tubulin folding intermediates by CCT/TriC	23	2.97e-06	5.63e-01	2.22e-05
Hh mutants abrogate ligand secretion	57	2.06e-13	5.62e-01	4.94e-12
Defective CFTR causes cystic fibrosis	58	1.36e-13	5.61e-01	3.48e-12
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	4.62e-04	5.61e-01	2.08e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.22e-06	5.60e-01	9.83e-06
PCNA-Dependent Long Patch Base Excision Repair	21	8.81e-06	5.60e-01	6.02e-05
NIK–>noncanonical NF-kB signaling	57	2.86e-13	5.59e-01	6.54e-12
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	1.34e-03	5.59e-01	5.37e-03
MASTL Facilitates Mitotic Progression	10	2.25e-03	5.58e-01	8.40e-03
Orc1 removal from chromatin	69	1.12e-15	5.57e-01	4.64e-14
Regulation of ornithine decarboxylase (ODC)	49	1.51e-11	5.57e-01	2.37e-10
Degradation of GLI2 by the proteasome	57	3.74e-13	5.56e-01	8.30e-12
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	2.63e-12	5.55e-01	4.65e-11
Cross-presentation of soluble exogenous antigens (endosomes)	47	4.83e-11	5.54e-01	6.98e-10
Mitochondrial translation elongation	90	1.01e-19	5.54e-01	7.17e-18
APC/C-mediated degradation of cell cycle proteins	86	9.55e-19	5.51e-01	5.47e-17
Regulation of mitotic cell cycle	86	9.55e-19	5.51e-01	5.47e-17
Mitochondrial translation termination	90	1.80e-19	5.50e-01	1.17e-17
Regulation of Apoptosis	51	1.08e-11	5.50e-01	1.71e-10
Mitochondrial translation initiation	90	2.62e-19	5.47e-01	1.63e-17
Translesion synthesis by POLI	17	9.88e-05	5.45e-01	5.55e-04
CDT1 association with the CDC6:ORC:origin complex	57	1.11e-12	5.44e-01	2.28e-11
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	4.33e-16	5.42e-01	1.90e-14
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	4.42e-04	5.42e-01	2.00e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	74	8.29e-16	5.41e-01	3.53e-14
Mitochondrial translation	96	6.18e-20	5.39e-01	4.60e-18
Activation of the pre-replicative complex	33	8.29e-08	5.39e-01	7.91e-07
Autodegradation of the E3 ubiquitin ligase COP1	49	6.59e-11	5.39e-01	9.30e-10
Degradation of GLI1 by the proteasome	57	1.97e-12	5.38e-01	3.76e-11
Cristae formation	31	2.17e-07	5.38e-01	1.98e-06
G1/S Transition	131	4.31e-26	5.34e-01	7.12e-24
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	4.26e-06	5.31e-01	3.12e-05
Regulation of APC/C activators between G1/S and early anaphase	79	3.21e-16	5.31e-01	1.59e-14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	6.87e-15	5.30e-01	2.32e-13
Processive synthesis on the lagging strand	15	3.91e-04	5.29e-01	1.79e-03
Recognition of DNA damage by PCNA-containing replication complex	30	5.76e-07	5.27e-01	4.93e-06
Cyclin E associated events during G1/S transition	83	1.04e-16	5.27e-01	5.51e-15
Dectin-1 mediated noncanonical NF-kB signaling	59	2.70e-12	5.26e-01	4.74e-11
Cholesterol biosynthesis	24	8.26e-06	5.26e-01	5.69e-05
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	2.01e-14	5.25e-01	5.99e-13
Mismatch Repair	15	4.69e-04	5.22e-01	2.10e-03
Synthesis of DNA	118	1.40e-22	5.20e-01	1.39e-20
G1/S DNA Damage Checkpoints	64	6.02e-13	5.20e-01	1.30e-11
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	7.86e-04	5.18e-01	3.32e-03
Translesion Synthesis by POLH	18	1.49e-04	5.16e-01	7.85e-04
p53-Dependent G1 DNA Damage Response	62	2.32e-12	5.15e-01	4.32e-11
p53-Dependent G1/S DNA damage checkpoint	62	2.32e-12	5.15e-01	4.32e-11
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	6.33e-14	5.11e-01	1.78e-12
Cyclin A:Cdk2-associated events at S phase entry	85	4.35e-16	5.10e-01	1.90e-14
Suppression of phagosomal maturation	13	1.54e-03	5.07e-01	6.08e-03
ROS sensing by NFE2L2	55	7.72e-11	5.07e-01	1.05e-09
Polymerase switching on the C-strand of the telomere	26	8.00e-06	5.06e-01	5.62e-05
Diseases associated with glycosylation precursor biosynthesis	18	2.10e-04	5.04e-01	1.04e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.09e-03	5.04e-01	4.53e-03
APC/C:Cdc20 mediated degradation of Securin	66	1.54e-12	5.03e-01	3.06e-11
Stabilization of p53	53	2.52e-10	5.02e-01	3.26e-09
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	3.68e-12	5.02e-01	6.37e-11
Hyaluronan uptake and degradation	10	6.43e-03	4.98e-01	2.10e-02
Polo-like kinase mediated events	16	6.10e-04	4.95e-01	2.67e-03
Glycogen storage diseases	14	1.47e-03	4.91e-01	5.80e-03
Regulation of HMOX1 expression and activity	63	1.74e-11	4.90e-01	2.70e-10
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	2.38e-03	4.87e-01	8.76e-03
Activation of ATR in response to replication stress	37	3.27e-07	4.85e-01	2.92e-06
Autodegradation of Cdh1 by Cdh1:APC/C	64	1.90e-11	4.85e-01	2.92e-10
CDK-mediated phosphorylation and removal of Cdc6	71	1.76e-12	4.84e-01	3.45e-11
S Phase	160	8.65e-26	4.80e-01	1.29e-23
Syndecan interactions	20	2.02e-04	4.80e-01	1.01e-03
Regulation of RUNX3 expression and activity	54	1.07e-09	4.80e-01	1.31e-08
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.90e-03	4.79e-01	7.28e-03
InlB-mediated entry of Listeria monocytogenes into host cell	15	1.35e-03	4.78e-01	5.42e-03
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.80e-05	4.77e-01	1.18e-04
Regulation of localization of FOXO transcription factors	12	4.50e-03	4.74e-01	1.53e-02
G0 and Early G1	27	2.23e-05	4.71e-01	1.43e-04
Signaling by NOTCH4	82	1.66e-13	4.71e-01	4.05e-12
Switching of origins to a post-replicative state	89	1.58e-14	4.71e-01	4.89e-13
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	30	8.20e-06	4.70e-01	5.69e-05
Advanced glycosylation endproduct receptor signaling	11	6.92e-03	4.70e-01	2.21e-02
Processing and activation of SUMO	10	1.01e-02	4.70e-01	3.02e-02
Activation of NF-kappaB in B cells	65	7.51e-11	4.67e-01	1.04e-09
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.30e-03	4.64e-01	5.29e-03
Degradation of DVL	55	2.83e-09	4.63e-01	3.34e-08
Synthesis, secretion, and deacylation of Ghrelin	13	3.89e-03	4.62e-01	1.33e-02
Transcription of E2F targets under negative control by DREAM complex	19	4.94e-04	4.62e-01	2.19e-03
Mitotic G1 phase and G1/S transition	147	7.60e-22	4.58e-01	7.07e-20
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	2.87e-06	4.57e-01	2.17e-05
Metabolism of polyamines	57	3.46e-09	4.52e-01	4.02e-08
Extension of Telomeres	51	2.45e-08	4.51e-01	2.55e-07
Degradation of AXIN	53	1.40e-08	4.50e-01	1.51e-07
Separation of Sister Chromatids	168	8.33e-24	4.49e-01	9.54e-22
HSF1 activation	26	7.49e-05	4.49e-01	4.39e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.40e-03	4.48e-01	5.56e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.40e-03	4.48e-01	5.56e-03
Regulation of mRNA stability by proteins that bind AU-rich elements	87	6.76e-13	4.45e-01	1.44e-11
Telomere Extension By Telomerase	23	2.27e-04	4.44e-01	1.10e-03
Synthesis of glycosylphosphatidylinositol (GPI)	18	1.15e-03	4.43e-01	4.69e-03
DNA Replication Pre-Initiation	108	1.90e-15	4.42e-01	7.45e-14
Cellular response to hypoxia	73	6.65e-11	4.42e-01	9.30e-10
Butyrophilin (BTN) family interactions	11	1.12e-02	-4.41e-01	3.34e-02
Caspase activation via Dependence Receptors in the absence of ligand	10	1.63e-02	-4.39e-01	4.51e-02
DNA Replication	151	2.10e-20	4.36e-01	1.74e-18
Downstream signaling events of B Cell Receptor (BCR)	79	2.89e-11	4.33e-01	4.31e-10
NRIF signals cell death from the nucleus	16	2.92e-03	4.30e-01	1.05e-02
Resolution of Sister Chromatid Cohesion	105	2.98e-14	4.29e-01	8.70e-13
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	34	1.55e-05	4.28e-01	1.02e-04
PINK1-PRKN Mediated Mitophagy	21	7.38e-04	4.25e-01	3.14e-03
Chaperone Mediated Autophagy	18	1.79e-03	4.25e-01	6.87e-03
Mitotic Metaphase and Anaphase	229	1.15e-28	4.25e-01	3.41e-26
Glutamate and glutamine metabolism	13	8.01e-03	4.25e-01	2.50e-02
Mitotic Anaphase	228	2.46e-28	4.23e-01	6.09e-26
Synthesis of very long-chain fatty acyl-CoAs	23	4.44e-04	4.23e-01	2.01e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	2.06e-02	4.23e-01	5.50e-02
Depolymerisation of the Nuclear Lamina	15	4.77e-03	4.21e-01	1.61e-02
Calnexin/calreticulin cycle	26	2.23e-04	4.18e-01	1.09e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	92	4.02e-12	4.18e-01	6.71e-11
Amplification of signal from the kinetochores	92	4.02e-12	4.18e-01	6.71e-11
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	2.19e-03	4.17e-01	8.17e-03
Downstream TCR signaling	90	8.06e-12	4.17e-01	1.32e-10
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	3.10e-04	4.17e-01	1.45e-03
ER-Phagosome pathway	86	2.36e-11	4.16e-01	3.59e-10
Regulation of RAS by GAPs	64	8.31e-09	4.16e-01	9.16e-08
Translation of Replicase and Assembly of the Replication Transcription Complex	13	9.43e-03	4.16e-01	2.87e-02
Antigen processing-Cross presentation	99	1.12e-12	4.13e-01	2.28e-11
Telomere C-strand (Lagging Strand) Synthesis	34	3.41e-05	4.11e-01	2.08e-04
Fatty acyl-CoA biosynthesis	35	2.95e-05	4.08e-01	1.85e-04
Telomere C-strand synthesis initiation	13	1.14e-02	4.05e-01	3.38e-02
FCERI mediated NF-kB activation	76	1.05e-09	4.05e-01	1.30e-08
EML4 and NUDC in mitotic spindle formation	96	8.27e-12	4.03e-01	1.34e-10
Asymmetric localization of PCP proteins	62	3.96e-08	4.03e-01	3.93e-07
Host Interactions of HIV factors	126	6.36e-15	4.02e-01	2.25e-13
Assembly of the pre-replicative complex	91	3.80e-11	4.01e-01	5.54e-10
VLDLR internalisation and degradation	11	2.14e-02	4.00e-01	5.69e-02
Pentose phosphate pathway	13	1.28e-02	3.99e-01	3.70e-02
APC-Cdc20 mediated degradation of Nek2A	26	4.40e-04	3.98e-01	2.00e-03
Nucleotide salvage	22	1.28e-03	3.97e-01	5.22e-03
Establishment of Sister Chromatid Cohesion	11	2.31e-02	3.96e-01	6.00e-02
ABC transporter disorders	74	3.98e-09	3.95e-01	4.49e-08
mRNA Capping	29	2.36e-04	3.94e-01	1.14e-03
Resolution of Abasic Sites (AP sites)	38	2.66e-05	3.94e-01	1.67e-04
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	1.40e-02	3.94e-01	3.97e-02
Defective EXT2 causes exostoses 2	13	1.40e-02	3.94e-01	3.97e-02
Regulation of RUNX2 expression and activity	70	1.27e-08	3.93e-01	1.39e-07
Detoxification of Reactive Oxygen Species	31	1.52e-04	3.93e-01	8.00e-04
ATF6 (ATF6-alpha) activates chaperones	12	1.85e-02	3.93e-01	5.01e-02
Class I peroxisomal membrane protein import	19	3.07e-03	3.92e-01	1.09e-02
Chromosome Maintenance	110	1.36e-12	3.91e-01	2.73e-11
Purine catabolism	16	6.95e-03	3.90e-01	2.21e-02
Cell Cycle Checkpoints	260	2.43e-27	3.89e-01	4.53e-25
Mitochondrial protein import	64	7.16e-08	3.89e-01	6.92e-07
E2F mediated regulation of DNA replication	22	1.66e-03	3.87e-01	6.46e-03
FOXO-mediated transcription of cell cycle genes	17	5.90e-03	3.86e-01	1.95e-02
Mitotic Spindle Checkpoint	109	3.73e-12	3.85e-01	6.37e-11
Metabolism of Angiotensinogen to Angiotensins	12	2.10e-02	3.85e-01	5.58e-02
FGFR1c ligand binding and activation	10	3.57e-02	-3.84e-01	8.67e-02
Crosslinking of collagen fibrils	10	3.62e-02	3.83e-01	8.75e-02
G2/M Checkpoints	140	5.59e-15	3.82e-01	2.08e-13
FGFR2 alternative splicing	25	1.02e-03	3.79e-01	4.29e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	125	2.64e-13	3.78e-01	6.15e-12
Diseases of carbohydrate metabolism	31	2.69e-04	3.78e-01	1.28e-03
Termination of translesion DNA synthesis	32	2.21e-04	3.77e-01	1.09e-03
Cyclin A/B1/B2 associated events during G2/M transition	25	1.14e-03	3.76e-01	4.69e-03
Lewis blood group biosynthesis	16	9.35e-03	-3.75e-01	2.85e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.00e-02	3.73e-01	5.39e-02
TP53 Regulates Transcription of Cell Cycle Genes	48	8.01e-06	3.72e-01	5.62e-05
Attenuation phase	23	2.01e-03	3.72e-01	7.60e-03
Collagen chain trimerization	42	3.02e-05	-3.72e-01	1.87e-04
SHC1 events in EGFR signaling	14	1.61e-02	3.71e-01	4.47e-02
Regulation of PTEN stability and activity	67	1.50e-07	3.71e-01	1.39e-06
TRP channels	19	5.20e-03	-3.70e-01	1.74e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	7.87e-05	3.70e-01	4.56e-04
eNOS activation	11	3.41e-02	3.69e-01	8.33e-02
Interconversion of nucleotide di- and triphosphates	29	6.25e-04	3.67e-01	2.73e-03
PD-1 signaling	18	7.26e-03	3.65e-01	2.29e-02
HS-GAG degradation	19	5.85e-03	3.65e-01	1.94e-02
MAPK6/MAPK4 signaling	87	3.96e-09	3.65e-01	4.49e-08
Reduction of cytosolic Ca++ levels	12	2.90e-02	3.64e-01	7.24e-02
RNA Pol II CTD phosphorylation and interaction with CE	27	1.14e-03	3.62e-01	4.69e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.14e-03	3.62e-01	4.69e-03
Interleukin-12 family signaling	51	8.22e-06	3.61e-01	5.69e-05
UCH proteinases	92	2.22e-09	3.61e-01	2.66e-08
HDR through Homologous Recombination (HRR)	66	4.52e-07	3.59e-01	3.91e-06
Interleukin-12 signaling	43	4.78e-05	3.58e-01	2.85e-04
APC/C:Cdc20 mediated degradation of Cyclin B	24	2.39e-03	3.58e-01	8.78e-03
Metabolism of non-coding RNA	53	8.05e-06	3.54e-01	5.62e-05
snRNP Assembly	53	8.05e-06	3.54e-01	5.62e-05
Disorders of Developmental Biology	13	2.73e-02	3.53e-01	6.89e-02
Disorders of Nervous System Development	13	2.73e-02	3.53e-01	6.89e-02
Loss of function of MECP2 in Rett syndrome	13	2.73e-02	3.53e-01	6.89e-02
Pervasive developmental disorders	13	2.73e-02	3.53e-01	6.89e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	2.21e-02	-3.53e-01	5.82e-02
SRP-dependent cotranslational protein targeting to membrane	110	1.53e-10	3.53e-01	2.00e-09
Translation	293	2.08e-25	3.53e-01	2.82e-23
Degradation of beta-catenin by the destruction complex	83	2.82e-08	3.52e-01	2.88e-07
RHO GTPases Activate Formins	119	4.99e-11	3.48e-01	7.13e-10
Dual Incision in GG-NER	41	1.22e-04	3.47e-01	6.76e-04
Post-chaperonin tubulin folding pathway	20	7.29e-03	3.47e-01	2.29e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	11	4.67e-02	3.46e-01	1.08e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	1.65e-06	3.46e-01	1.30e-05
Dual incision in TC-NER	65	1.38e-06	3.46e-01	1.10e-05
Insulin receptor recycling	24	3.35e-03	3.46e-01	1.17e-02
LDL clearance	17	1.35e-02	3.46e-01	3.86e-02
Cell Cycle, Mitotic	513	4.04e-41	3.45e-01	2.00e-38
Presynaptic phase of homologous DNA pairing and strand exchange	39	1.94e-04	3.45e-01	9.77e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	2.96e-04	3.44e-01	1.39e-03
Abortive elongation of HIV-1 transcript in the absence of Tat	23	4.37e-03	3.43e-01	1.48e-02
Negative regulation of MET activity	21	6.56e-03	3.43e-01	2.12e-02
Dissolution of Fibrin Clot	12	4.02e-02	3.42e-01	9.51e-02
Heme biosynthesis	13	3.30e-02	3.42e-01	8.15e-02
Homologous DNA Pairing and Strand Exchange	42	1.28e-04	3.41e-01	6.96e-04
Aggrephagy	21	6.85e-03	3.41e-01	2.19e-02
Cellular response to chemical stress	150	5.49e-13	3.41e-01	1.20e-11
RUNX1 regulates transcription of genes involved in differentiation of HSCs	89	2.86e-08	3.40e-01	2.89e-07
TNFR2 non-canonical NF-kB pathway	90	2.45e-08	3.40e-01	2.55e-07
Inactivation of APC/C via direct inhibition of the APC/C complex	21	7.01e-03	3.40e-01	2.22e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	7.01e-03	3.40e-01	2.22e-02
Respiratory electron transport	103	2.48e-09	3.40e-01	2.95e-08
PCP/CE pathway	90	2.50e-08	3.40e-01	2.57e-07
Zinc transporters	15	2.38e-02	3.37e-01	6.14e-02
Formation of RNA Pol II elongation complex	57	1.06e-05	3.37e-01	7.04e-05
RNA Polymerase II Transcription Elongation	57	1.06e-05	3.37e-01	7.04e-05
DNA Damage Bypass	47	6.34e-05	3.37e-01	3.74e-04
G2/M Transition	181	6.01e-15	3.36e-01	2.18e-13
Initiation of Nuclear Envelope (NE) Reformation	19	1.15e-02	3.35e-01	3.39e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	6.62e-03	3.34e-01	2.13e-02
Activation of BAD and translocation to mitochondria	15	2.50e-02	3.34e-01	6.40e-02
Regulation of expression of SLITs and ROBOs	166	1.10e-13	3.34e-01	2.86e-12
Mitotic G2-G2/M phases	183	8.19e-15	3.32e-01	2.65e-13
TCR signaling	110	1.69e-09	3.32e-01	2.06e-08
Cell Cycle	638	6.43e-47	3.32e-01	9.56e-44
Glycogen synthesis	15	2.60e-02	3.32e-01	6.63e-02
Cytoprotection by HMOX1	120	3.36e-10	3.32e-01	4.27e-09
Endosomal/Vacuolar pathway	12	4.67e-02	3.32e-01	1.08e-01
Interleukin-1 signaling	96	1.99e-08	3.31e-01	2.10e-07
M Phase	371	4.70e-28	3.31e-01	1.00e-25
The citric acid (TCA) cycle and respiratory electron transport	174	4.80e-14	3.31e-01	1.37e-12
Sealing of the nuclear envelope (NE) by ESCRT-III	29	2.04e-03	3.31e-01	7.71e-03
Mitotic Prometaphase	186	6.87e-15	3.31e-01	2.32e-13
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	4.57e-07	3.30e-01	3.93e-06
ATF6 (ATF6-alpha) activates chaperone genes	10	7.09e-02	3.30e-01	1.53e-01
Triglyceride catabolism	19	1.29e-02	3.29e-01	3.73e-02
Phosphorylation of CD3 and TCR zeta chains	17	1.95e-02	3.27e-01	5.27e-02
Signaling by the B Cell Receptor (BCR)	106	6.14e-09	3.27e-01	6.82e-08
GRB2 events in EGFR signaling	13	4.15e-02	3.26e-01	9.76e-02
Sensory perception of sweet, bitter, and umami (glutamate) taste	22	8.10e-03	-3.26e-01	2.52e-02
Signaling by BMP	23	6.89e-03	-3.25e-01	2.20e-02
HDMs demethylate histones	22	8.27e-03	-3.25e-01	2.56e-02
Hyaluronan metabolism	14	3.52e-02	3.25e-01	8.58e-02
HIV Transcription Initiation	47	1.29e-04	3.23e-01	6.96e-04
RNA Polymerase II HIV Promoter Escape	47	1.29e-04	3.23e-01	6.96e-04
RNA Polymerase II Promoter Escape	47	1.29e-04	3.23e-01	6.96e-04
RNA Polymerase II Transcription Initiation	47	1.29e-04	3.23e-01	6.96e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance	47	1.29e-04	3.23e-01	6.96e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	47	1.29e-04	3.23e-01	6.96e-04
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	4.40e-02	3.23e-01	1.03e-01
Cargo concentration in the ER	31	1.98e-03	3.21e-01	7.55e-03
Response of Mtb to phagocytosis	22	9.24e-03	3.21e-01	2.82e-02
Regulated proteolysis of p75NTR	11	6.64e-02	3.20e-01	1.47e-01
Sodium/Calcium exchangers	11	6.64e-02	3.20e-01	1.47e-01
Phospholipase C-mediated cascade: FGFR1	14	3.93e-02	-3.18e-01	9.33e-02
Deposition of new CENPA-containing nucleosomes at the centromere	45	2.22e-04	3.18e-01	1.09e-03
Nucleosome assembly	45	2.22e-04	3.18e-01	1.09e-03
Infection with Mycobacterium tuberculosis	24	7.09e-03	3.17e-01	2.24e-02
Telomere Maintenance	85	4.16e-07	3.17e-01	3.64e-06
Vitamin B5 (pantothenate) metabolism	17	2.35e-02	3.17e-01	6.10e-02
HS-GAG biosynthesis	28	3.87e-03	3.15e-01	1.33e-02
COPI-dependent Golgi-to-ER retrograde traffic	80	1.09e-06	3.15e-01	8.84e-06
Removal of the Flap Intermediate from the C-strand	17	2.48e-02	3.15e-01	6.35e-02
Pyruvate metabolism	29	3.40e-03	3.14e-01	1.19e-02
Chondroitin sulfate biosynthesis	20	1.50e-02	3.14e-01	4.22e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	6.59e-07	3.14e-01	5.51e-06
ABC-family proteins mediated transport	99	6.84e-08	3.14e-01	6.65e-07
ER Quality Control Compartment (ERQC)	21	1.29e-02	3.13e-01	3.72e-02
Complex I biogenesis	57	4.65e-05	3.12e-01	2.79e-04
Nuclear Envelope (NE) Reassembly	73	4.10e-06	3.12e-01	3.02e-05
MHC class II antigen presentation	99	8.39e-08	3.11e-01	7.95e-07
RHO GTPases Activate NADPH Oxidases	22	1.16e-02	3.11e-01	3.42e-02
Defective B3GAT3 causes JDSSDHD	19	1.90e-02	3.11e-01	5.16e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.26e-03	3.11e-01	5.14e-03
Blood group systems biosynthesis	20	1.67e-02	-3.09e-01	4.60e-02
The role of Nef in HIV-1 replication and disease pathogenesis	25	7.48e-03	3.09e-01	2.34e-02
Receptor-type tyrosine-protein phosphatases	19	2.02e-02	-3.08e-01	5.43e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	2.38e-02	3.08e-01	6.14e-02
The activation of arylsulfatases	10	9.20e-02	3.08e-01	1.90e-01
FGFR1 ligand binding and activation	14	4.63e-02	-3.08e-01	1.08e-01
RNA Polymerase II Pre-transcription Events	80	1.97e-06	3.07e-01	1.54e-05
Interleukin-6 family signaling	23	1.07e-02	3.07e-01	3.20e-02
Defective B4GALT7 causes EDS, progeroid type	19	2.05e-02	3.07e-01	5.50e-02
Golgi Associated Vesicle Biogenesis	55	8.26e-05	3.07e-01	4.73e-04
IRAK1 recruits IKK complex	10	9.30e-02	3.07e-01	1.91e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	9.30e-02	3.07e-01	1.91e-01
Heparan sulfate/heparin (HS-GAG) metabolism	50	1.76e-04	3.06e-01	9.02e-04
Ribosomal scanning and start codon recognition	57	6.26e-05	3.06e-01	3.71e-04
Signaling by ROBO receptors	211	1.74e-14	3.06e-01	5.28e-13
Gap junction trafficking	18	2.47e-02	3.06e-01	6.35e-02
Adherens junctions interactions	28	5.15e-03	3.05e-01	1.73e-02
mRNA Splicing - Minor Pathway	52	1.42e-04	3.05e-01	7.50e-04
Formation of the ternary complex, and subsequently, the 43S complex	50	1.91e-04	3.05e-01	9.65e-04
HIV Infection	224	3.42e-15	3.05e-01	1.31e-13
Nucleotide Excision Repair	110	3.32e-08	3.05e-01	3.32e-07
Laminin interactions	23	1.14e-02	3.05e-01	3.38e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	36	1.57e-03	-3.04e-01	6.13e-03
CLEC7A (Dectin-1) signaling	97	2.22e-07	3.04e-01	2.01e-06
STAT3 nuclear events downstream of ALK signaling	10	9.61e-02	3.04e-01	1.96e-01
Translation initiation complex formation	57	7.28e-05	3.04e-01	4.28e-04
Phosphorylation of the APC/C	20	1.91e-02	3.03e-01	5.18e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	19	2.25e-02	3.02e-01	5.91e-02
RUNX2 regulates osteoblast differentiation	23	1.24e-02	-3.01e-01	3.61e-02
Post-translational protein phosphorylation	86	1.36e-06	3.01e-01	1.08e-05
Cyclin D associated events in G1	45	4.71e-04	3.01e-01	2.10e-03
G1 Phase	45	4.71e-04	3.01e-01	2.10e-03
RHOH GTPase cycle	35	2.08e-03	3.01e-01	7.82e-03
E3 ubiquitin ligases ubiquitinate target proteins	53	1.69e-04	2.99e-01	8.75e-04
Cell-cell junction organization	53	1.70e-04	2.98e-01	8.76e-04
MECP2 regulates neuronal receptors and channels	17	3.33e-02	2.98e-01	8.20e-02
Mitophagy	28	6.48e-03	2.97e-01	2.11e-02
Josephin domain DUBs	10	1.04e-01	2.97e-01	2.08e-01
Mitotic Telophase/Cytokinesis	13	6.40e-02	2.97e-01	1.42e-01
Apoptosis	171	2.54e-11	2.95e-01	3.81e-10
Protein localization	159	1.25e-10	2.95e-01	1.67e-09
Golgi-to-ER retrograde transport	113	6.06e-08	2.95e-01	5.97e-07
Activation of the TFAP2 (AP-2) family of transcription factors	11	9.09e-02	-2.94e-01	1.89e-01
RHOF GTPase cycle	41	1.14e-03	2.94e-01	4.69e-03
Lysosome Vesicle Biogenesis	34	3.08e-03	2.93e-01	1.09e-02
Metabolic disorders of biological oxidation enzymes	30	5.45e-03	2.93e-01	1.81e-02
FGFR2 mutant receptor activation	30	5.48e-03	2.93e-01	1.82e-02
BBSome-mediated cargo-targeting to cilium	21	2.06e-02	2.92e-01	5.50e-02
Formation of the Early Elongation Complex	33	3.73e-03	2.92e-01	1.29e-02
Formation of the HIV-1 Early Elongation Complex	33	3.73e-03	2.92e-01	1.29e-02
Kinesins	41	1.32e-03	2.90e-01	5.33e-03
Signaling by NOTCH3	47	5.91e-04	2.90e-01	2.60e-03
Diseases associated with N-glycosylation of proteins	17	3.88e-02	2.89e-01	9.24e-02
Translocation of ZAP-70 to Immunological synapse	15	5.23e-02	2.89e-01	1.20e-01
Viral Messenger RNA Synthesis	44	9.07e-04	2.89e-01	3.82e-03
Gap junction degradation	10	1.14e-01	2.88e-01	2.24e-01
Smooth Muscle Contraction	33	4.17e-03	2.88e-01	1.42e-02
Signaling by CSF3 (G-CSF)	30	6.58e-03	2.87e-01	2.12e-02
RHO GTPases activate IQGAPs	11	1.00e-01	2.86e-01	2.02e-01
Sensory perception of taste	27	1.02e-02	-2.85e-01	3.07e-02
ADP signalling through P2Y purinoceptor 12	18	3.64e-02	2.85e-01	8.77e-02
RAF-independent MAPK1/3 activation	23	1.83e-02	2.84e-01	4.99e-02
ROS and RNS production in phagocytes	32	5.40e-03	2.84e-01	1.80e-02
DNA Damage Recognition in GG-NER	38	2.51e-03	2.83e-01	9.16e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	36	3.38e-03	2.82e-01	1.18e-02
trans-Golgi Network Vesicle Budding	71	4.07e-05	2.81e-01	2.47e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	2.08e-04	2.81e-01	1.04e-03
RHO GTPases activate CIT	19	3.38e-02	2.81e-01	8.28e-02
Activated NOTCH1 Transmits Signal to the Nucleus	31	6.79e-03	2.81e-01	2.18e-02
Biotin transport and metabolism	11	1.07e-01	2.80e-01	2.12e-01
Listeria monocytogenes entry into host cells	20	3.01e-02	2.80e-01	7.50e-02
Eicosanoid ligand-binding receptors	12	9.32e-02	-2.80e-01	1.91e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	21	2.67e-02	-2.79e-01	6.80e-02
Diseases associated with glycosaminoglycan metabolism	36	3.76e-03	2.79e-01	1.30e-02
Gluconeogenesis	29	9.53e-03	2.78e-01	2.89e-02
Neutrophil degranulation	424	7.47e-23	2.78e-01	7.94e-21
Formation of TC-NER Pre-Incision Complex	53	4.65e-04	2.78e-01	2.09e-03
Cellular hexose transport	18	4.15e-02	2.78e-01	9.76e-02
Influenza Infection	153	3.59e-09	2.76e-01	4.14e-08
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.95e-04	2.76e-01	1.80e-03
Non-integrin membrane-ECM interactions	42	1.96e-03	2.76e-01	7.51e-03
Activation of Matrix Metalloproteinases	27	1.34e-02	-2.75e-01	3.83e-02
Homology Directed Repair	111	5.86e-07	2.74e-01	4.95e-06
Programmed Cell Death	197	3.02e-11	2.74e-01	4.44e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression	13	8.78e-02	-2.73e-01	1.86e-01
Pyroptosis	24	2.08e-02	2.73e-01	5.54e-02
Apoptotic cleavage of cell adhesion proteins	10	1.36e-01	2.72e-01	2.52e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	15	6.89e-02	-2.71e-01	1.50e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	2.94e-10	2.71e-01	3.77e-09
Selective autophagy	58	3.60e-04	2.71e-01	1.67e-03
EGFR downregulation	31	9.22e-03	2.70e-01	2.82e-02
NR1H2 and NR1H3-mediated signaling	44	1.99e-03	-2.69e-01	7.59e-03
Gap junction trafficking and regulation	20	3.73e-02	2.69e-01	8.95e-02
Nuclear Envelope Breakdown	53	7.09e-04	2.69e-01	3.04e-03
Intrinsic Pathway for Apoptosis	53	7.20e-04	2.68e-01	3.07e-03
Activation of Ca-permeable Kainate Receptor	10	1.42e-01	-2.68e-01	2.60e-01
Ionotropic activity of kainate receptors	10	1.42e-01	-2.68e-01	2.60e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	2.66e-03	2.68e-01	9.61e-03
HIV Transcription Elongation	42	2.66e-03	2.68e-01	9.61e-03
Tat-mediated elongation of the HIV-1 transcript	42	2.66e-03	2.68e-01	9.61e-03
Activation of BH3-only proteins	29	1.25e-02	2.68e-01	3.64e-02
Metabolism of nucleotides	91	1.01e-05	2.68e-01	6.79e-05
COPII-mediated vesicle transport	66	1.71e-04	2.67e-01	8.76e-04
Diseases of mitotic cell cycle	38	4.68e-03	2.65e-01	1.58e-02
Apoptotic execution phase	49	1.33e-03	2.65e-01	5.37e-03
RUNX2 regulates bone development	30	1.20e-02	-2.65e-01	3.52e-02
Fc epsilon receptor (FCERI) signaling	128	2.41e-07	2.64e-01	2.17e-06
Regulation of gene expression in beta cells	16	6.75e-02	2.64e-01	1.47e-01
Iron uptake and transport	56	6.41e-04	2.64e-01	2.78e-03
Processing of Capped Intronless Pre-mRNA	28	1.58e-02	2.64e-01	4.40e-02
Cap-dependent Translation Initiation	117	8.51e-07	2.63e-01	7.00e-06
Eukaryotic Translation Initiation	117	8.51e-07	2.63e-01	7.00e-06
A tetrasaccharide linker sequence is required for GAG synthesis	25	2.29e-02	2.63e-01	5.98e-02
Intra-Golgi traffic	43	2.89e-03	2.62e-01	1.04e-02
Transcriptional Regulation by E2F6	34	8.12e-03	2.62e-01	2.52e-02
Metabolism of fat-soluble vitamins	36	6.46e-03	2.62e-01	2.10e-02
RNA polymerase II transcribes snRNA genes	71	1.33e-04	2.62e-01	7.10e-04
Influenza Viral RNA Transcription and Replication	134	1.64e-07	2.62e-01	1.50e-06
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	97	8.32e-06	2.62e-01	5.71e-05
Pausing and recovery of Tat-mediated HIV elongation	30	1.31e-02	2.62e-01	3.77e-02
Tat-mediated HIV elongation arrest and recovery	30	1.31e-02	2.62e-01	3.77e-02
Pexophagy	11	1.34e-01	2.61e-01	2.50e-01
IL-6-type cytokine receptor ligand interactions	16	7.11e-02	2.61e-01	1.53e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	110	2.32e-06	2.61e-01	1.78e-05
SARS-CoV-1 Infection	50	1.50e-03	2.60e-01	5.90e-03
GPVI-mediated activation cascade	30	1.39e-02	2.59e-01	3.97e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	2.30e-02	2.58e-01	5.98e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	13	1.08e-01	-2.57e-01	2.14e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	105	5.57e-06	2.56e-01	4.00e-05
Formation of HIV elongation complex in the absence of HIV Tat	44	3.45e-03	2.55e-01	1.20e-02
Pregnenolone biosynthesis	12	1.27e-01	2.55e-01	2.40e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.27e-01	2.55e-01	2.40e-01
alpha-linolenic acid (ALA) metabolism	12	1.27e-01	2.55e-01	2.40e-01
C-type lectin receptors (CLRs)	128	6.43e-07	2.55e-01	5.41e-06
Mucopolysaccharidoses	11	1.44e-01	2.54e-01	2.63e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	1.27e-01	2.54e-01	2.41e-01
L13a-mediated translational silencing of Ceruloplasmin expression	109	4.49e-06	2.54e-01	3.28e-05
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	2.79e-02	2.54e-01	6.99e-02
Glycogen breakdown (glycogenolysis)	15	8.89e-02	-2.54e-01	1.87e-01
Transcription of the HIV genome	69	2.70e-04	2.54e-01	1.28e-03
Phase 2 - plateau phase	15	9.13e-02	-2.52e-01	1.89e-01
Digestion and absorption	12	1.31e-01	-2.52e-01	2.47e-01
Regulation of HSF1-mediated heat shock response	78	1.31e-04	2.50e-01	7.03e-04
Processive synthesis on the C-strand of the telomere	19	5.93e-02	2.50e-01	1.34e-01
Macroautophagy	111	5.34e-06	2.50e-01	3.86e-05
Formation of a pool of free 40S subunits	99	1.92e-05	2.48e-01	1.24e-04
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	9.66e-02	2.48e-01	1.96e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	9.66e-02	2.48e-01	1.96e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	9.77e-02	2.47e-01	1.98e-01
MAPK3 (ERK1) activation	10	1.76e-01	2.47e-01	3.06e-01
Chaperonin-mediated protein folding	85	8.46e-05	2.47e-01	4.82e-04
tRNA processing in the nucleus	59	1.10e-03	2.46e-01	4.56e-03
Postmitotic nuclear pore complex (NPC) reformation	27	2.73e-02	2.45e-01	6.89e-02
Signaling by EGFR in Cancer	25	3.42e-02	2.45e-01	8.33e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	16	9.04e-02	2.45e-01	1.89e-01
HIV elongation arrest and recovery	32	1.69e-02	2.44e-01	4.64e-02
Pausing and recovery of HIV elongation	32	1.69e-02	2.44e-01	4.64e-02
COPI-independent Golgi-to-ER retrograde traffic	33	1.53e-02	2.44e-01	4.28e-02
WNT5A-dependent internalization of FZD4	15	1.02e-01	2.44e-01	2.04e-01
Collagen degradation	36	1.14e-02	-2.43e-01	3.38e-02
Apoptotic cleavage of cellular proteins	36	1.14e-02	2.43e-01	3.38e-02
RND1 GTPase cycle	42	6.32e-03	2.43e-01	2.07e-02
Transcriptional regulation by RUNX3	94	4.48e-05	2.43e-01	2.70e-04
Metal ion SLC transporters	24	3.93e-02	2.43e-01	9.33e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	8.33e-02	2.43e-01	1.77e-01
Formation of Incision Complex in GG-NER	43	6.09e-03	2.42e-01	2.01e-02
TNFR1-induced NFkappaB signaling pathway	26	3.30e-02	-2.41e-01	8.15e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	53	2.35e-03	2.41e-01	8.69e-03
Cargo recognition for clathrin-mediated endocytosis	100	3.07e-05	2.41e-01	1.88e-04
Synthesis of IP3 and IP4 in the cytosol	25	3.69e-02	-2.41e-01	8.89e-02
Defective C1GALT1C1 causes TNPS	13	1.33e-01	2.41e-01	2.48e-01
DSCAM interactions	10	1.87e-01	-2.41e-01	3.22e-01
Synthesis of PIPs at the late endosome membrane	11	1.67e-01	-2.41e-01	2.94e-01
Signaling by EGFR	50	3.29e-03	2.40e-01	1.16e-02
Glucagon-type ligand receptors	25	3.77e-02	2.40e-01	9.01e-02
Glycosphingolipid metabolism	40	8.66e-03	2.40e-01	2.66e-02
Transferrin endocytosis and recycling	30	2.30e-02	2.40e-01	5.98e-02
Intraflagellar transport	39	9.66e-03	2.39e-01	2.92e-02
Eukaryotic Translation Termination	91	8.16e-05	2.39e-01	4.69e-04
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	1.71e-01	2.38e-01	2.98e-01
HDR through MMEJ (alt-NHEJ)	10	1.92e-01	2.38e-01	3.27e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	1.71e-01	-2.38e-01	2.98e-01
Negative regulation of MAPK pathway	43	6.82e-03	2.38e-01	2.19e-02
Asparagine N-linked glycosylation	277	8.05e-12	2.38e-01	1.32e-10
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	7.70e-05	2.37e-01	4.49e-04
Transcriptional regulation by RUNX2	116	1.04e-05	2.37e-01	6.97e-05
Synaptic adhesion-like molecules	20	6.69e-02	-2.37e-01	1.47e-01
O-linked glycosylation of mucins	55	2.45e-03	2.36e-01	8.97e-03
FCGR activation	11	1.75e-01	-2.36e-01	3.05e-01
Pyrimidine catabolism	11	1.81e-01	2.33e-01	3.12e-01
mTORC1-mediated signalling	24	4.81e-02	2.33e-01	1.11e-01
Pyrimidine salvage	11	1.81e-01	2.33e-01	3.12e-01
Retrograde neurotrophin signalling	14	1.32e-01	2.32e-01	2.48e-01
Viral mRNA Translation	87	1.84e-04	2.32e-01	9.32e-04
Interleukin-10 signaling	35	1.77e-02	2.32e-01	4.86e-02
Tight junction interactions	23	5.46e-02	2.31e-01	1.25e-01
Signaling by ERBB4	54	3.41e-03	2.30e-01	1.19e-02
RHOG GTPase cycle	74	6.39e-04	2.29e-01	2.78e-03
IRE1alpha activates chaperones	50	5.01e-03	2.29e-01	1.69e-02
DNA Double-Strand Break Repair	140	2.89e-06	2.29e-01	2.17e-05
Diseases of glycosylation	132	5.66e-06	2.29e-01	4.05e-05
Presynaptic depolarization and calcium channel opening	12	1.70e-01	-2.29e-01	2.98e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	1.39e-01	2.28e-01	2.56e-01
Glycosaminoglycan metabolism	111	3.19e-05	2.28e-01	1.95e-04
Selenocysteine synthesis	91	1.67e-04	2.28e-01	8.70e-04
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	12	1.72e-01	2.28e-01	3.00e-01
Binding and Uptake of Ligands by Scavenger Receptors	34	2.16e-02	2.28e-01	5.72e-02
Peroxisomal protein import	60	2.30e-03	2.27e-01	8.55e-03
Diseases of metabolism	220	5.99e-09	2.27e-01	6.70e-08
Peptide chain elongation	87	2.50e-04	2.27e-01	1.20e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	3.03e-05	2.27e-01	1.87e-04
Nonsense-Mediated Decay (NMD)	113	3.03e-05	2.27e-01	1.87e-04
Metabolism of vitamins and cofactors	173	2.58e-07	2.27e-01	2.31e-06
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	1.17e-01	2.27e-01	2.27e-01
Retinoid metabolism and transport	32	2.66e-02	2.26e-01	6.79e-02
Chondroitin sulfate/dermatan sulfate metabolism	49	6.13e-03	2.26e-01	2.01e-02
WNT ligand biogenesis and trafficking	24	5.53e-02	2.26e-01	1.26e-01
Base Excision Repair	64	1.78e-03	2.26e-01	6.84e-03
Disorders of transmembrane transporters	157	1.03e-06	2.26e-01	8.37e-06
RHO GTPase Effectors	258	4.13e-10	2.26e-01	5.21e-09
RHO GTPases Activate ROCKs	19	8.90e-02	2.25e-01	1.87e-01
Protein folding	91	2.04e-04	2.25e-01	1.02e-03
Hedgehog ‘off’ state	96	1.42e-04	2.25e-01	7.50e-04
Autophagy	125	1.50e-05	2.24e-01	9.85e-05
Regulation of PLK1 Activity at G2/M Transition	87	3.11e-04	2.24e-01	1.45e-03
RAB geranylgeranylation	62	2.33e-03	2.24e-01	8.62e-03
TRAF6 mediated IRF7 activation	17	1.11e-01	-2.23e-01	2.17e-01
Nuclear Pore Complex (NPC) Disassembly	36	2.05e-02	2.23e-01	5.49e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	8.51e-02	2.22e-01	1.80e-01
GAB1 signalosome	17	1.13e-01	2.22e-01	2.21e-01
Signaling by FGFR2 in disease	40	1.55e-02	2.21e-01	4.33e-02
RORA activates gene expression	18	1.04e-01	-2.21e-01	2.09e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	9.57e-02	2.21e-01	1.96e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	9.57e-02	2.21e-01	1.96e-01
Mitochondrial Fatty Acid Beta-Oxidation	36	2.19e-02	2.21e-01	5.79e-02
Insulin processing	25	5.64e-02	2.20e-01	1.28e-01
SARS-CoV-2 Infection	71	1.36e-03	2.20e-01	5.44e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	8.92e-02	-2.20e-01	1.87e-01
DNA Repair	298	6.69e-11	2.19e-01	9.30e-10
Eukaryotic Translation Elongation	92	2.75e-04	2.19e-01	1.30e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	9.05e-02	2.19e-01	1.89e-01
Neurodegenerative Diseases	20	9.05e-02	2.19e-01	1.89e-01
Major pathway of rRNA processing in the nucleolus and cytosol	180	4.20e-07	2.18e-01	3.65e-06
Transport of vitamins, nucleosides, and related molecules	35	2.54e-02	2.18e-01	6.49e-02
Synthesis of PC	28	4.56e-02	2.18e-01	1.06e-01
Retrograde transport at the Trans-Golgi-Network	49	8.43e-03	2.17e-01	2.61e-02
Assembly and cell surface presentation of NMDA receptors	25	6.07e-02	-2.17e-01	1.36e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.22e-01	2.17e-01	2.34e-01
Plasma lipoprotein clearance	30	4.01e-02	2.17e-01	9.50e-02
Rap1 signalling	15	1.47e-01	2.16e-01	2.67e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	1.47e-01	2.16e-01	2.67e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	24	6.70e-02	2.16e-01	1.47e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	24	6.70e-02	2.16e-01	1.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	24	6.70e-02	2.16e-01	1.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	24	6.70e-02	2.16e-01	1.47e-01
Diseases of DNA Double-Strand Break Repair	24	6.70e-02	2.16e-01	1.47e-01
ER to Golgi Anterograde Transport	131	2.06e-05	2.15e-01	1.33e-04
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	2.39e-01	2.15e-01	3.86e-01
Incretin synthesis, secretion, and inactivation	19	1.05e-01	2.15e-01	2.09e-01
Interactions of Vpr with host cellular proteins	37	2.39e-02	2.15e-01	6.15e-02
Interleukin-1 family signaling	128	2.75e-05	2.14e-01	1.73e-04
Hedgehog ‘on’ state	84	6.81e-04	2.14e-01	2.95e-03
Regulation of beta-cell development	33	3.33e-02	2.14e-01	8.20e-02
Post-translational modification: synthesis of GPI-anchored proteins	68	2.33e-03	2.13e-01	8.62e-03
rRNA processing in the nucleus and cytosol	190	3.84e-07	2.13e-01	3.38e-06
Nuclear import of Rev protein	34	3.14e-02	2.13e-01	7.76e-02
Killing mechanisms	12	2.01e-01	2.13e-01	3.41e-01
WNT5:FZD7-mediated leishmania damping	12	2.01e-01	2.13e-01	3.41e-01
Interleukin-15 signaling	14	1.68e-01	2.13e-01	2.95e-01
Deactivation of the beta-catenin transactivating complex	41	1.84e-02	2.13e-01	5.01e-02
Apoptotic factor-mediated response	19	1.09e-01	2.13e-01	2.14e-01
Protein ubiquitination	73	1.71e-03	2.12e-01	6.61e-03
SUMOylation of DNA replication proteins	46	1.27e-02	2.12e-01	3.69e-02
DARPP-32 events	23	7.81e-02	2.12e-01	1.67e-01
Resolution of D-Loop Structures	33	3.59e-02	2.11e-01	8.71e-02
Glyoxylate metabolism and glycine degradation	26	6.28e-02	2.11e-01	1.40e-01
Processing of DNA double-strand break ends	72	2.01e-03	2.10e-01	7.60e-03
Metabolism of porphyrins	22	8.80e-02	2.10e-01	1.86e-01
G beta:gamma signalling through PI3Kgamma	23	8.17e-02	2.10e-01	1.74e-01
Signaling by NOTCH2	33	3.71e-02	2.10e-01	8.93e-02
HDR through Single Strand Annealing (SSA)	37	2.75e-02	2.09e-01	6.92e-02
Association of TriC/CCT with target proteins during biosynthesis	37	2.78e-02	2.09e-01	6.96e-02
Inactivation of CSF3 (G-CSF) signaling	25	7.07e-02	2.09e-01	1.53e-01
Peptide hormone metabolism	70	2.57e-03	2.08e-01	9.37e-03
RHO GTPases activate PAKs	21	9.85e-02	2.08e-01	1.99e-01
COPI-mediated anterograde transport	79	1.44e-03	2.07e-01	5.70e-03
Oncogenic MAPK signaling	77	1.69e-03	2.07e-01	6.58e-03
Unfolded Protein Response (UPR)	92	6.08e-04	2.07e-01	2.67e-03
Synthesis of bile acids and bile salts	31	4.65e-02	-2.07e-01	1.08e-01
mRNA Splicing - Major Pathway	179	1.93e-06	2.06e-01	1.52e-05
Platelet degranulation	112	1.64e-04	2.06e-01	8.60e-04
RND3 GTPase cycle	41	2.25e-02	2.06e-01	5.91e-02
Export of Viral Ribonucleoproteins from Nucleus	33	4.07e-02	2.06e-01	9.60e-02
Spry regulation of FGF signaling	16	1.54e-01	2.06e-01	2.76e-01
Factors involved in megakaryocyte development and platelet production	120	9.80e-05	2.06e-01	5.52e-04
Metabolism of RNA	677	5.92e-20	2.05e-01	4.60e-18
Interactions of Rev with host cellular proteins	37	3.06e-02	2.05e-01	7.61e-02
Triglyceride metabolism	29	5.57e-02	2.05e-01	1.27e-01
Diseases of DNA repair	34	3.83e-02	2.05e-01	9.16e-02
Regulation of TP53 Activity through Phosphorylation	91	7.20e-04	2.05e-01	3.07e-03
Fatty acid metabolism	156	1.16e-05	2.03e-01	7.68e-05
Defective GALNT12 causes CRCS1	12	2.24e-01	2.03e-01	3.68e-01
RHOJ GTPase cycle	54	9.97e-03	2.03e-01	3.00e-02
Transport of the SLBP Dependant Mature mRNA	36	3.56e-02	2.02e-01	8.67e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	1.34e-02	2.02e-01	3.84e-02
Methylation	14	1.91e-01	2.02e-01	3.26e-01
Mitotic Prophase	104	3.72e-04	2.02e-01	1.71e-03
XBP1(S) activates chaperone genes	48	1.56e-02	2.02e-01	4.35e-02
Fanconi Anemia Pathway	36	3.62e-02	2.02e-01	8.75e-02
Late Phase of HIV Life Cycle	135	5.19e-05	2.02e-01	3.09e-04
Phenylalanine and tyrosine metabolism	10	2.70e-01	2.02e-01	4.24e-01
mRNA Splicing	187	1.98e-06	2.01e-01	1.54e-05
Response to elevated platelet cytosolic Ca2+	117	1.66e-04	2.01e-01	8.68e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	5.80e-04	2.00e-01	2.56e-03
PERK regulates gene expression	32	5.02e-02	2.00e-01	1.16e-01
HSF1-dependent transactivation	33	4.77e-02	1.99e-01	1.10e-01
Citric acid cycle (TCA cycle)	22	1.06e-01	1.99e-01	2.11e-01
Other semaphorin interactions	15	1.83e-01	1.98e-01	3.15e-01
Synthesis of IP2, IP, and Ins in the cytosol	14	1.99e-01	-1.98e-01	3.38e-01
Neurotoxicity of clostridium toxins	10	2.78e-01	1.98e-01	4.35e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	75	3.05e-03	1.98e-01	1.09e-02
Neddylation	223	3.83e-07	1.97e-01	3.38e-06
Unblocking of NMDA receptors, glutamate binding and activation	20	1.27e-01	-1.97e-01	2.41e-01
Defective Intrinsic Pathway for Apoptosis	22	1.10e-01	1.97e-01	2.17e-01
Activation of gene expression by SREBF (SREBP)	42	2.75e-02	1.96e-01	6.92e-02
RHO GTPases Activate WASPs and WAVEs	36	4.14e-02	1.96e-01	9.76e-02
Late endosomal microautophagy	30	6.28e-02	1.96e-01	1.40e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	5.50e-02	1.96e-01	1.26e-01
Activation of SMO	18	1.50e-01	-1.96e-01	2.70e-01
HIV Life Cycle	147	4.10e-05	1.96e-01	2.48e-04
Signaling by NOTCH	196	2.28e-06	1.96e-01	1.77e-05
Initial triggering of complement	15	1.90e-01	-1.96e-01	3.25e-01
Metabolism of amino acids and derivatives	344	4.39e-10	1.95e-01	5.49e-09
RHOD GTPase cycle	53	1.43e-02	1.94e-01	4.06e-02
Nuclear signaling by ERBB4	29	7.02e-02	1.94e-01	1.52e-01
Metabolism of proteins	1758	1.71e-42	1.94e-01	1.27e-39
Cell junction organization	78	3.10e-03	1.94e-01	1.10e-02
TP53 Regulates Metabolic Genes	85	2.07e-03	1.93e-01	7.80e-03
MET activates PTK2 signaling	18	1.56e-01	1.93e-01	2.78e-01
Transcriptional regulation of granulopoiesis	52	1.63e-02	1.92e-01	4.53e-02
Basigin interactions	23	1.11e-01	1.92e-01	2.17e-01
LGI-ADAM interactions	13	2.31e-01	-1.92e-01	3.77e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	32	6.01e-02	1.92e-01	1.35e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	2.33e-01	1.91e-01	3.79e-01
ALK mutants bind TKIs	12	2.52e-01	1.91e-01	4.01e-01
Beta-catenin independent WNT signaling	142	8.73e-05	1.91e-01	4.96e-04
Mitochondrial iron-sulfur cluster biogenesis	13	2.35e-01	1.90e-01	3.80e-01
ISG15 antiviral mechanism	72	5.24e-03	1.90e-01	1.75e-02
TP53 Regulates Transcription of DNA Repair Genes	61	1.02e-02	1.90e-01	3.07e-02
Transport of the SLBP independent Mature mRNA	35	5.18e-02	1.90e-01	1.19e-01
Regulation of TLR by endogenous ligand	14	2.18e-01	1.90e-01	3.61e-01
G2/M DNA damage checkpoint	69	6.50e-03	1.89e-01	2.11e-02
SHC1 events in ERBB2 signaling	22	1.25e-01	1.89e-01	2.38e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	6.48e-02	1.89e-01	1.44e-01
Interaction between L1 and Ankyrins	26	9.69e-02	-1.88e-01	1.97e-01
Signaling by Hippo	20	1.46e-01	1.88e-01	2.65e-01
Early Phase of HIV Life Cycle	13	2.42e-01	1.88e-01	3.89e-01
FGFR1 mutant receptor activation	29	8.15e-02	-1.87e-01	1.73e-01
Glucose metabolism	84	3.06e-03	1.87e-01	1.09e-02
Metabolism of carbohydrates	266	1.51e-07	1.87e-01	1.40e-06
Sphingolipid metabolism	83	3.26e-03	1.87e-01	1.15e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.85e-01	1.86e-01	4.44e-01
Lysine catabolism	12	2.65e-01	-1.86e-01	4.19e-01
Miscellaneous transport and binding events	23	1.23e-01	1.86e-01	2.36e-01
CDC6 association with the ORC:origin complex	11	2.86e-01	1.86e-01	4.46e-01
Metalloprotease DUBs	26	1.02e-01	1.85e-01	2.04e-01
Signaling by Leptin	10	3.11e-01	-1.85e-01	4.73e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	9.05e-02	1.85e-01	1.89e-01
Vitamin D (calciferol) metabolism	10	3.12e-01	1.85e-01	4.74e-01
Rev-mediated nuclear export of HIV RNA	35	5.89e-02	1.84e-01	1.33e-01
Scavenging by Class A Receptors	18	1.77e-01	1.84e-01	3.06e-01
Heme signaling	43	3.72e-02	-1.84e-01	8.93e-02
Apoptosis induced DNA fragmentation	12	2.73e-01	1.83e-01	4.28e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	2.22e-01	1.82e-01	3.65e-01
Signaling by FGFR1 in disease	36	5.92e-02	-1.82e-01	1.33e-01
Cellular response to heat stress	96	2.10e-03	1.82e-01	7.88e-03
Voltage gated Potassium channels	33	7.15e-02	-1.81e-01	1.54e-01
Cellular responses to stimuli	691	3.65e-16	1.81e-01	1.75e-14
rRNA processing	214	4.94e-06	1.81e-01	3.59e-05
Signaling by Hedgehog	133	3.34e-04	1.80e-01	1.55e-03
Signaling by MET	66	1.17e-02	1.79e-01	3.45e-02
Response of EIF2AK1 (HRI) to heme deficiency	15	2.30e-01	-1.79e-01	3.76e-01
ERBB2 Regulates Cell Motility	15	2.31e-01	1.78e-01	3.78e-01
MAP2K and MAPK activation	36	6.48e-02	1.78e-01	1.44e-01
RNA Polymerase I Transcription Termination	30	9.21e-02	1.78e-01	1.90e-01
Transport to the Golgi and subsequent modification	161	9.97e-05	1.78e-01	5.58e-04
G beta:gamma signalling through BTK	16	2.20e-01	1.77e-01	3.63e-01
RA biosynthesis pathway	18	1.93e-01	1.77e-01	3.29e-01
RAS processing	19	1.83e-01	1.77e-01	3.15e-01
Aflatoxin activation and detoxification	14	2.53e-01	1.76e-01	4.03e-01
Platelet calcium homeostasis	25	1.28e-01	1.76e-01	2.41e-01
rRNA modification in the nucleus and cytosol	60	1.85e-02	1.76e-01	5.01e-02
SUMOylation of transcription cofactors	44	4.36e-02	-1.76e-01	1.02e-01
VEGFR2 mediated vascular permeability	26	1.21e-01	1.76e-01	2.33e-01
Cellular response to starvation	150	2.01e-04	1.76e-01	1.01e-03
Glutamate Neurotransmitter Release Cycle	24	1.36e-01	-1.76e-01	2.52e-01
Infectious disease	747	2.70e-16	1.75e-01	1.38e-14
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	26	1.22e-01	1.75e-01	2.34e-01
Regulation of Complement cascade	30	9.98e-02	-1.74e-01	2.01e-01
STING mediated induction of host immune responses	15	2.45e-01	-1.74e-01	3.92e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.80e-01	1.73e-01	3.11e-01
Transcriptional Regulation by TP53	356	1.92e-08	1.73e-01	2.04e-07
Cellular responses to stress	681	1.14e-14	1.73e-01	3.62e-13
Generation of second messenger molecules	29	1.07e-01	1.73e-01	2.12e-01
Signaling by FGFR2	67	1.48e-02	1.72e-01	4.17e-02
RAC2 GTPase cycle	86	5.81e-03	1.72e-01	1.93e-02
Bile acid and bile salt metabolism	38	6.65e-02	-1.72e-01	1.47e-01
Metabolism	1909	7.03e-36	1.71e-01	2.62e-33
AURKA Activation by TPX2	72	1.24e-02	1.70e-01	3.62e-02
FOXO-mediated transcription	61	2.17e-02	1.70e-01	5.75e-02
TNFR1-induced proapoptotic signaling	13	2.89e-01	-1.70e-01	4.48e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	2.40e-01	1.69e-01	3.88e-01
Translation of Structural Proteins	29	1.16e-01	1.69e-01	2.26e-01
Acyl chain remodelling of PI	12	3.12e-01	1.69e-01	4.74e-01
Regulation of FZD by ubiquitination	21	1.81e-01	1.69e-01	3.12e-01
Amino acid transport across the plasma membrane	31	1.05e-01	-1.68e-01	2.10e-01
RHOBTB2 GTPase cycle	23	1.65e-01	1.67e-01	2.90e-01
Defective GALNT3 causes HFTC	12	3.16e-01	1.67e-01	4.77e-01
G beta:gamma signalling through CDC42	18	2.19e-01	1.67e-01	3.62e-01
FOXO-mediated transcription of cell death genes	15	2.62e-01	-1.67e-01	4.15e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	2.33e-01	1.67e-01	3.80e-01
Metabolism of folate and pterines	16	2.48e-01	1.67e-01	3.97e-01
Recycling of bile acids and salts	13	2.98e-01	-1.67e-01	4.59e-01
Antiviral mechanism by IFN-stimulated genes	80	9.96e-03	1.67e-01	3.00e-02
The canonical retinoid cycle in rods (twilight vision)	20	1.97e-01	-1.66e-01	3.36e-01
Clathrin-mediated endocytosis	138	7.59e-04	1.66e-01	3.22e-03
NOTCH3 Intracellular Domain Regulates Transcription	23	1.68e-01	1.66e-01	2.96e-01
Phospholipase C-mediated cascade; FGFR3	11	3.43e-01	-1.65e-01	5.11e-01
FLT3 signaling in disease	28	1.31e-01	1.65e-01	2.46e-01
SUMOylation of immune response proteins	11	3.44e-01	-1.65e-01	5.13e-01
Nucleotide catabolism	32	1.07e-01	1.64e-01	2.12e-01
Signaling by PDGFR in disease	20	2.05e-01	1.64e-01	3.45e-01
AKT phosphorylates targets in the cytosol	14	2.89e-01	1.64e-01	4.48e-01
Activated NTRK2 signals through FRS2 and FRS3	11	3.49e-01	1.63e-01	5.17e-01
Signaling by Interleukins	394	2.91e-08	1.62e-01	2.93e-07
Glutathione conjugation	30	1.24e-01	1.62e-01	2.37e-01
CS/DS degradation	14	2.94e-01	1.62e-01	4.55e-01
Selenoamino acid metabolism	115	2.74e-03	1.62e-01	9.87e-03
N-Glycan antennae elongation	14	2.96e-01	-1.61e-01	4.56e-01
NS1 Mediated Effects on Host Pathways	40	7.80e-02	1.61e-01	1.67e-01
Vesicle-mediated transport	614	8.56e-12	1.61e-01	1.37e-10
Gamma carboxylation, hypusine formation and arylsulfatase activation	37	9.08e-02	1.61e-01	1.89e-01
Aquaporin-mediated transport	39	8.30e-02	1.60e-01	1.76e-01
cGMP effects	14	2.99e-01	1.60e-01	4.59e-01
Metabolism of water-soluble vitamins and cofactors	119	2.63e-03	1.60e-01	9.59e-03
Prostacyclin signalling through prostacyclin receptor	17	2.55e-01	1.59e-01	4.05e-01
RNA Polymerase III Chain Elongation	18	2.43e-01	1.59e-01	3.90e-01
Processing of Capped Intron-Containing Pre-mRNA	238	2.36e-05	1.59e-01	1.51e-04
PIWI-interacting RNA (piRNA) biogenesis	26	1.61e-01	1.59e-01	2.86e-01
Innate Immune System	875	1.28e-15	1.59e-01	5.15e-14
Complement cascade	38	9.15e-02	-1.58e-01	1.90e-01
Protein-protein interactions at synapses	79	1.51e-02	-1.58e-01	4.24e-02
Acetylcholine regulates insulin secretion	10	3.88e-01	1.58e-01	5.57e-01
Post-translational protein modification	1280	1.44e-21	1.58e-01	1.26e-19
Regulation of RUNX1 Expression and Activity	18	2.47e-01	-1.57e-01	3.96e-01
Signal transduction by L1	21	2.12e-01	1.57e-01	3.52e-01
Intrinsic Pathway of Fibrin Clot Formation	17	2.62e-01	1.57e-01	4.15e-01
Disease	1474	3.06e-24	1.57e-01	3.79e-22
Membrane Trafficking	582	9.20e-11	1.57e-01	1.24e-09
Constitutive Signaling by Overexpressed ERBB2	11	3.69e-01	1.56e-01	5.42e-01
Transport of bile salts and organic acids, metal ions and amine compounds	62	3.35e-02	1.56e-01	8.22e-02
Downregulation of ERBB2:ERBB3 signaling	13	3.30e-01	1.56e-01	4.95e-01
Keratan sulfate/keratin metabolism	29	1.46e-01	1.56e-01	2.66e-01
Thromboxane signalling through TP receptor	22	2.07e-01	1.55e-01	3.48e-01
Hemostasis	505	2.08e-09	1.55e-01	2.51e-08
Recruitment of NuMA to mitotic centrosomes	80	1.64e-02	1.55e-01	4.53e-02
Vpr-mediated nuclear import of PICs	34	1.19e-01	1.54e-01	2.31e-01
Class I MHC mediated antigen processing & presentation	356	5.85e-07	1.54e-01	4.95e-06
Interleukin-4 and Interleukin-13 signaling	98	8.47e-03	1.54e-01	2.62e-02
Regulation of gene expression by Hypoxia-inducible Factor	11	3.78e-01	1.54e-01	5.47e-01
Interleukin-6 signaling	11	3.78e-01	1.54e-01	5.47e-01
Branched-chain amino acid catabolism	21	2.24e-01	1.53e-01	3.68e-01
Metabolism of steroids	140	1.75e-03	1.53e-01	6.78e-03
Glycolysis	67	3.09e-02	1.52e-01	7.66e-02
EPH-ephrin mediated repulsion of cells	47	7.26e-02	1.51e-01	1.56e-01
Formation of the cornified envelope	34	1.27e-01	-1.51e-01	2.41e-01
Synthesis of substrates in N-glycan biosythesis	60	4.42e-02	1.50e-01	1.03e-01
RIP-mediated NFkB activation via ZBP1	16	2.99e-01	-1.50e-01	4.59e-01
Signaling by high-kinase activity BRAF mutants	32	1.42e-01	1.50e-01	2.60e-01
MAPK1/MAPK3 signaling	264	2.65e-05	1.50e-01	1.67e-04
Metabolism of steroid hormones	31	1.48e-01	1.50e-01	2.68e-01
Platelet homeostasis	76	2.44e-02	1.49e-01	6.28e-02
Transcriptional regulation by RUNX1	190	3.83e-04	1.49e-01	1.76e-03
Vasopressin regulates renal water homeostasis via Aquaporins	36	1.21e-01	1.49e-01	2.34e-01
Signaling by PDGFRA extracellular domain mutants	12	3.72e-01	1.49e-01	5.43e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.72e-01	1.49e-01	5.43e-01
Interleukin-20 family signaling	19	2.62e-01	-1.49e-01	4.15e-01
SARS-CoV Infections	151	1.62e-03	1.49e-01	6.32e-03
Anchoring of the basal body to the plasma membrane	97	1.20e-02	1.48e-01	3.51e-02
Signaling by FGFR3 fusions in cancer	10	4.19e-01	1.47e-01	5.88e-01
G beta:gamma signalling through PLC beta	18	2.80e-01	1.47e-01	4.37e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	2.32e-01	1.47e-01	3.79e-01
Centrosome maturation	81	2.29e-02	1.46e-01	5.98e-02
Recruitment of mitotic centrosome proteins and complexes	81	2.29e-02	1.46e-01	5.98e-02
Regulated Necrosis	51	7.09e-02	1.46e-01	1.53e-01
IRAK2 mediated activation of TAK1 complex	10	4.24e-01	1.46e-01	5.93e-01
Phase 0 - rapid depolarisation	30	1.67e-01	-1.46e-01	2.94e-01
Cell-Cell communication	109	8.66e-03	1.45e-01	2.66e-02
SUMOylation of DNA damage response and repair proteins	76	2.85e-02	1.45e-01	7.14e-02
SHC1 events in ERBB4 signaling	14	3.47e-01	1.45e-01	5.15e-01
EPH-Ephrin signaling	90	1.83e-02	1.44e-01	4.99e-02
Signaling by Non-Receptor Tyrosine Kinases	54	6.87e-02	1.43e-01	1.50e-01
Signaling by PTK6	54	6.87e-02	1.43e-01	1.50e-01
p130Cas linkage to MAPK signaling for integrins	13	3.72e-01	-1.43e-01	5.43e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	26	2.07e-01	-1.43e-01	3.48e-01
SUMOylation of RNA binding proteins	47	9.05e-02	1.43e-01	1.89e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	2.18e-01	-1.42e-01	3.60e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.64e-01	1.42e-01	2.89e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.64e-01	1.42e-01	2.89e-01
PTEN Regulation	140	3.67e-03	1.42e-01	1.27e-02
IRF3-mediated induction of type I IFN	12	3.94e-01	-1.42e-01	5.63e-01
PKMTs methylate histone lysines	46	9.57e-02	-1.42e-01	1.96e-01
Activation of G protein gated Potassium channels	26	2.10e-01	1.42e-01	3.50e-01
G protein gated Potassium channels	26	2.10e-01	1.42e-01	3.50e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	26	2.10e-01	1.42e-01	3.50e-01
Transcriptional regulation by small RNAs	69	4.23e-02	1.41e-01	9.92e-02
Costimulation by the CD28 family	60	5.82e-02	1.41e-01	1.32e-01
Assembly of collagen fibrils and other multimeric structures	55	6.99e-02	-1.41e-01	1.52e-01
Cilium Assembly	181	1.04e-03	1.41e-01	4.34e-03
Diseases of signal transduction by growth factor receptors and second messengers	414	7.91e-07	1.41e-01	6.57e-06
Platelet Aggregation (Plug Formation)	32	1.69e-01	-1.40e-01	2.96e-01
RAF activation	34	1.56e-01	1.40e-01	2.79e-01
Signaling by FLT3 ITD and TKD mutants	16	3.31e-01	1.40e-01	4.96e-01
Degradation of the extracellular matrix	97	1.69e-02	-1.40e-01	4.65e-02
MAPK family signaling cascades	303	2.64e-05	1.40e-01	1.67e-04
STAT5 activation downstream of FLT3 ITD mutants	10	4.43e-01	1.40e-01	6.08e-01
Signaling by FGFR	81	2.93e-02	1.40e-01	7.30e-02
Platelet activation, signaling and aggregation	231	2.47e-04	1.40e-01	1.19e-03
Cytokine Signaling in Immune system	614	3.04e-09	1.40e-01	3.57e-08
Axon guidance	504	7.47e-08	1.40e-01	7.17e-07
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.90e-01	1.38e-01	3.26e-01
RAF/MAP kinase cascade	258	1.31e-04	1.38e-01	7.03e-04
Cargo trafficking to the periciliary membrane	47	1.02e-01	1.38e-01	2.04e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	3.26e-01	1.38e-01	4.90e-01
Activation of GABAB receptors	38	1.42e-01	1.38e-01	2.60e-01
GABA B receptor activation	38	1.42e-01	1.38e-01	2.60e-01
ATF4 activates genes in response to endoplasmic reticulum stress	27	2.18e-01	1.37e-01	3.61e-01
G alpha (z) signalling events	42	1.25e-01	1.37e-01	2.38e-01
Sphingolipid de novo biosynthesis	43	1.21e-01	1.37e-01	2.33e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	57	7.41e-02	-1.37e-01	1.59e-01
Repression of WNT target genes	14	3.76e-01	-1.37e-01	5.46e-01
Trafficking of GluR2-containing AMPA receptors	16	3.45e-01	1.36e-01	5.13e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.22e-01	1.36e-01	2.34e-01
Transcriptional Regulation by VENTX	38	1.46e-01	-1.36e-01	2.66e-01
TCF dependent signaling in response to WNT	188	1.31e-03	1.36e-01	5.29e-03
Loss of Nlp from mitotic centrosomes	69	5.13e-02	1.36e-01	1.18e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	5.13e-02	1.36e-01	1.18e-01
TNF signaling	44	1.20e-01	-1.35e-01	2.32e-01
Ion homeostasis	47	1.08e-01	1.35e-01	2.14e-01
tRNA processing in the mitochondrion	20	2.95e-01	-1.35e-01	4.55e-01
EPHA-mediated growth cone collapse	15	3.66e-01	1.35e-01	5.38e-01
MET receptor recycling	10	4.61e-01	-1.35e-01	6.29e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	2.97e-01	1.35e-01	4.58e-01
TRAF3-dependent IRF activation pathway	14	3.83e-01	-1.35e-01	5.52e-01
Adaptive Immune System	656	3.90e-09	1.34e-01	4.46e-08
Nervous system development	527	1.48e-07	1.33e-01	1.39e-06
ABC transporters in lipid homeostasis	17	3.41e-01	-1.33e-01	5.09e-01
NOTCH4 Intracellular Domain Regulates Transcription	20	3.05e-01	1.32e-01	4.67e-01
GABA receptor activation	50	1.05e-01	1.32e-01	2.10e-01
SUMOylation of ubiquitinylation proteins	39	1.53e-01	1.32e-01	2.74e-01
Signaling by ERBB2 ECD mutants	16	3.60e-01	1.32e-01	5.31e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	2.04e-01	1.32e-01	3.44e-01
Immune System	1671	1.44e-19	1.32e-01	9.73e-18
Deadenylation-dependent mRNA decay	53	9.81e-02	1.31e-01	1.99e-01
Cohesin Loading onto Chromatin	10	4.73e-01	1.31e-01	6.39e-01
Antigen processing: Ubiquitination & Proteasome degradation	293	1.13e-04	1.31e-01	6.32e-04
Signaling by Rho GTPases	629	1.90e-08	1.31e-01	2.04e-07
Extra-nuclear estrogen signaling	70	5.84e-02	1.31e-01	1.32e-01
Phospholipase C-mediated cascade; FGFR2	15	3.81e-01	-1.31e-01	5.50e-01
RNA Polymerase III Transcription Initiation	36	1.76e-01	1.30e-01	3.06e-01
Negative regulation of FLT3	14	3.98e-01	1.30e-01	5.67e-01
Phospholipase C-mediated cascade; FGFR4	12	4.34e-01	-1.30e-01	6.03e-01
Signaling by WNT	282	1.79e-04	1.29e-01	9.12e-04
RND2 GTPase cycle	41	1.52e-01	1.29e-01	2.73e-01
Downstream signaling of activated FGFR1	29	2.31e-01	-1.29e-01	3.78e-01
Norepinephrine Neurotransmitter Release Cycle	17	3.60e-01	-1.28e-01	5.31e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	645	2.49e-08	1.28e-01	2.57e-07
Collagen biosynthesis and modifying enzymes	65	7.38e-02	-1.28e-01	1.58e-01
Glucagon signaling in metabolic regulation	28	2.41e-01	1.28e-01	3.88e-01
Adenylate cyclase inhibitory pathway	12	4.43e-01	1.28e-01	6.08e-01
Inhibition of DNA recombination at telomere	40	1.62e-01	1.28e-01	2.87e-01
Organelle biogenesis and maintenance	272	2.82e-04	1.28e-01	1.33e-03
Meiotic recombination	47	1.30e-01	1.28e-01	2.45e-01
RHOBTB GTPase Cycle	35	1.92e-01	1.27e-01	3.27e-01
Amino acids regulate mTORC1	51	1.15e-01	1.27e-01	2.25e-01
Constitutive Signaling by EGFRvIII	15	3.93e-01	1.27e-01	5.61e-01
Signaling by EGFRvIII in Cancer	15	3.93e-01	1.27e-01	5.61e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	2.44e-01	1.27e-01	3.91e-01
Arachidonic acid metabolism	44	1.47e-01	1.26e-01	2.66e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	4.49e-01	1.26e-01	6.16e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	3.99e-01	1.26e-01	5.67e-01
Uptake and function of anthrax toxins	11	4.73e-01	-1.25e-01	6.39e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	1.63e-01	1.24e-01	2.89e-01
SUMOylation of SUMOylation proteins	35	2.06e-01	1.24e-01	3.46e-01
HDACs deacetylate histones	54	1.17e-01	-1.23e-01	2.27e-01
Plasma lipoprotein assembly	13	4.41e-01	1.23e-01	6.08e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	3.52e-01	-1.23e-01	5.21e-01
Dopamine Neurotransmitter Release Cycle	23	3.08e-01	-1.23e-01	4.70e-01
RHOQ GTPase cycle	58	1.06e-01	1.23e-01	2.11e-01
Diseases of programmed cell death	62	9.64e-02	1.22e-01	1.96e-01
Phase II - Conjugation of compounds	79	6.11e-02	1.22e-01	1.36e-01
Interleukin-7 signaling	23	3.13e-01	1.22e-01	4.74e-01
Inositol phosphate metabolism	46	1.54e-01	-1.22e-01	2.75e-01
Metabolism of lipids	668	8.44e-08	1.21e-01	7.95e-07
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	36	2.09e-01	1.21e-01	3.50e-01
Erythropoietin activates RAS	14	4.34e-01	1.21e-01	6.03e-01
tRNA processing	124	2.03e-02	1.21e-01	5.44e-02
G-protein activation	20	3.52e-01	1.20e-01	5.21e-01
Antimicrobial peptides	26	2.89e-01	1.20e-01	4.48e-01
MyD88 deficiency (TLR2/4)	14	4.38e-01	1.20e-01	6.05e-01
Phase 4 - resting membrane potential	16	4.09e-01	-1.19e-01	5.79e-01
ESR-mediated signaling	177	6.36e-03	1.19e-01	2.08e-02
PI-3K cascade:FGFR1	19	3.71e-01	-1.18e-01	5.43e-01
Neurexins and neuroligins	50	1.48e-01	-1.18e-01	2.68e-01
NRAGE signals death through JNK	59	1.17e-01	-1.18e-01	2.27e-01
Amine ligand-binding receptors	23	3.29e-01	1.18e-01	4.93e-01
Uptake and actions of bacterial toxins	29	2.74e-01	1.17e-01	4.29e-01
ADORA2B mediated anti-inflammatory cytokines production	86	6.06e-02	1.17e-01	1.36e-01
PPARA activates gene expression	111	3.35e-02	1.17e-01	8.22e-02
Interleukin-27 signaling	10	5.25e-01	1.16e-01	6.90e-01
Defective pyroptosis	35	2.35e-01	1.16e-01	3.80e-01
G-protein beta:gamma signalling	30	2.72e-01	1.16e-01	4.27e-01
Transcriptional activation of mitochondrial biogenesis	53	1.48e-01	-1.15e-01	2.67e-01
RHO GTPases activate PKNs	53	1.48e-01	1.15e-01	2.68e-01
Acetylcholine Neurotransmitter Release Cycle	16	4.28e-01	-1.14e-01	5.98e-01
Regulation of IFNG signaling	13	4.76e-01	1.14e-01	6.41e-01
Interferon Signaling	178	8.83e-03	1.14e-01	2.71e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58	1.34e-01	1.14e-01	2.50e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	58	1.34e-01	1.14e-01	2.50e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	58	1.34e-01	1.14e-01	2.50e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	58	1.34e-01	1.14e-01	2.50e-01
Signaling by NOTCH1 in Cancer	58	1.34e-01	1.14e-01	2.50e-01
Regulation of TP53 Activity	155	1.46e-02	1.14e-01	4.12e-02
NCAM signaling for neurite out-growth	56	1.42e-01	-1.13e-01	2.60e-01
Developmental Biology	870	1.40e-08	1.13e-01	1.51e-07
Recycling pathway of L1	27	3.10e-01	1.13e-01	4.73e-01
Plasma lipoprotein assembly, remodeling, and clearance	58	1.38e-01	1.13e-01	2.54e-01
Signaling by NODAL	19	3.95e-01	-1.13e-01	5.64e-01
FCGR3A-mediated IL10 synthesis	35	2.49e-01	-1.13e-01	3.97e-01
Regulation of lipid metabolism by PPARalpha	113	3.90e-02	1.12e-01	9.29e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	16	4.37e-01	-1.12e-01	6.04e-01
Diseases associated with the TLR signaling cascade	27	3.15e-01	-1.12e-01	4.76e-01
Diseases of Immune System	27	3.15e-01	-1.12e-01	4.76e-01
Carboxyterminal post-translational modifications of tubulin	37	2.40e-01	1.12e-01	3.87e-01
Reactions specific to the complex N-glycan synthesis pathway	10	5.42e-01	-1.11e-01	7.02e-01
Ub-specific processing proteases	178	1.04e-02	1.11e-01	3.10e-02
Netrin-1 signaling	46	1.92e-01	-1.11e-01	3.28e-01
PKA activation	16	4.43e-01	1.11e-01	6.08e-01
Estrogen-dependent gene expression	110	4.62e-02	1.10e-01	1.08e-01
Sensory processing of sound by inner hair cells of the cochlea	58	1.49e-01	1.10e-01	2.68e-01
SHC-mediated cascade:FGFR4	17	4.35e-01	1.09e-01	6.03e-01
Long-term potentiation	22	3.75e-01	-1.09e-01	5.46e-01
RNA Polymerase I Promoter Opening	25	3.46e-01	-1.09e-01	5.14e-01
Transport of small molecules	620	3.52e-06	1.09e-01	2.62e-05
Signaling by ERBB2 TMD/JMD mutants	22	3.80e-01	1.08e-01	5.50e-01
Synthesis of PA	32	2.94e-01	-1.07e-01	4.55e-01
DAP12 interactions	33	2.87e-01	1.07e-01	4.46e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.35e-01	1.07e-01	5.01e-01
RAC3 GTPase cycle	91	7.81e-02	1.07e-01	1.67e-01
Signaling by BRAF and RAF1 fusions	60	1.52e-01	1.07e-01	2.73e-01
PIP3 activates AKT signaling	257	3.21e-03	1.07e-01	1.13e-02
Signal amplification	29	3.23e-01	1.06e-01	4.87e-01
Serotonin Neurotransmitter Release Cycle	18	4.37e-01	-1.06e-01	6.04e-01
Deubiquitination	250	3.94e-03	1.06e-01	1.35e-02
Diseases associated with visual transduction	10	5.64e-01	-1.05e-01	7.17e-01
Diseases of the neuronal system	10	5.64e-01	-1.05e-01	7.17e-01
Retinoid cycle disease events	10	5.64e-01	-1.05e-01	7.17e-01
Defects in cobalamin (B12) metabolism	13	5.11e-01	-1.05e-01	6.76e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	24	3.75e-01	1.05e-01	5.46e-01
MET promotes cell motility	29	3.31e-01	1.04e-01	4.96e-01
RAB GEFs exchange GTP for GDP on RABs	88	9.10e-02	1.04e-01	1.89e-01
Signaling by NOTCH1	74	1.22e-01	1.04e-01	2.34e-01
Platelet sensitization by LDL	16	4.72e-01	1.04e-01	6.39e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	15	4.87e-01	-1.04e-01	6.53e-01
Chromatin modifying enzymes	226	7.47e-03	-1.03e-01	2.34e-02
Chromatin organization	226	7.47e-03	-1.03e-01	2.34e-02
TBC/RABGAPs	43	2.43e-01	-1.03e-01	3.90e-01
PKA activation in glucagon signalling	15	4.92e-01	1.02e-01	6.58e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	4.94e-01	1.02e-01	6.59e-01
VEGFA-VEGFR2 Pathway	91	9.25e-02	1.02e-01	1.91e-01
ZBP1(DAI) mediated induction of type I IFNs	19	4.42e-01	-1.02e-01	6.08e-01
Senescence-Associated Secretory Phenotype (SASP)	72	1.35e-01	1.02e-01	2.51e-01
Elastic fibre formation	37	2.86e-01	1.01e-01	4.45e-01
Signaling by TGF-beta Receptor Complex	74	1.32e-01	1.01e-01	2.47e-01
Condensation of Prophase Chromosomes	35	3.00e-01	1.01e-01	4.59e-01
TGF-beta receptor signaling activates SMADs	32	3.22e-01	1.01e-01	4.85e-01
SHC-mediated cascade:FGFR3	16	4.87e-01	1.00e-01	6.53e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	2.68e-01	9.99e-02	4.22e-01
Signaling by RAS mutants	41	2.68e-01	9.99e-02	4.22e-01
Signaling by moderate kinase activity BRAF mutants	41	2.68e-01	9.99e-02	4.22e-01
Signaling downstream of RAS mutants	41	2.68e-01	9.99e-02	4.22e-01
Sensory processing of sound	63	1.70e-01	9.99e-02	2.98e-01
N-glycan antennae elongation in the medial/trans-Golgi	25	3.88e-01	-9.96e-02	5.57e-01
Mitochondrial biogenesis	91	1.01e-01	9.93e-02	2.04e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	5.69e-01	9.93e-02	7.22e-01
Nucleotide-like (purinergic) receptors	11	5.70e-01	-9.90e-02	7.23e-01
Integration of energy metabolism	97	9.25e-02	9.88e-02	1.91e-01
Regulation of KIT signaling	15	5.08e-01	-9.88e-02	6.73e-01
FRS-mediated FGFR1 signaling	21	4.34e-01	-9.87e-02	6.03e-01
Protein methylation	15	5.09e-01	-9.86e-02	6.73e-01
AKT phosphorylates targets in the nucleus	10	5.90e-01	9.84e-02	7.40e-01
Amyloid fiber formation	60	1.88e-01	9.82e-02	3.23e-01
Signaling by Receptor Tyrosine Kinases	482	2.25e-04	9.79e-02	1.10e-03
Presynaptic function of Kainate receptors	19	4.62e-01	9.75e-02	6.29e-01
Budding and maturation of HIV virion	28	3.73e-01	9.73e-02	5.44e-01
Common Pathway of Fibrin Clot Formation	15	5.15e-01	9.71e-02	6.78e-01
Processing of Intronless Pre-mRNAs	19	4.64e-01	9.70e-02	6.31e-01
Meiosis	77	1.44e-01	9.64e-02	2.63e-01
Signaling by ERBB2	50	2.38e-01	9.64e-02	3.86e-01
Negative regulation of FGFR4 signaling	28	3.78e-01	9.63e-02	5.47e-01
Nicotinate metabolism	29	3.73e-01	9.55e-02	5.44e-01
O-glycosylation of TSR domain-containing proteins	37	3.15e-01	-9.55e-02	4.76e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	6.01e-01	-9.54e-02	7.48e-01
Lysosphingolipid and LPA receptors	12	5.68e-01	-9.52e-02	7.21e-01
Sema3A PAK dependent Axon repulsion	16	5.10e-01	9.52e-02	6.74e-01
Signaling by Insulin receptor	73	1.61e-01	9.49e-02	2.85e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	31	3.62e-01	9.46e-02	5.33e-01
Signaling by Activin	15	5.26e-01	-9.45e-02	6.91e-01
Thrombin signalling through proteinase activated receptors (PARs)	30	3.70e-01	9.45e-02	5.43e-01
Regulation of TNFR1 signaling	35	3.36e-01	-9.40e-02	5.01e-01
Signaling by FGFR in disease	60	2.13e-01	9.29e-02	3.54e-01
RHO GTPases activate KTN1	11	5.95e-01	9.25e-02	7.43e-01
Cytosolic tRNA aminoacylation	24	4.33e-01	-9.24e-02	6.03e-01
RNA Polymerase II Transcription Termination	65	1.99e-01	9.22e-02	3.37e-01
RHOA GTPase cycle	146	5.52e-02	9.19e-02	1.26e-01
Signaling by Nuclear Receptors	245	1.35e-02	9.16e-02	3.85e-02
Mitochondrial tRNA aminoacylation	21	4.68e-01	9.15e-02	6.34e-01
S33 mutants of beta-catenin aren’t phosphorylated	15	5.41e-01	9.12e-02	7.01e-01
S37 mutants of beta-catenin aren’t phosphorylated	15	5.41e-01	9.12e-02	7.01e-01
S45 mutants of beta-catenin aren’t phosphorylated	15	5.41e-01	9.12e-02	7.01e-01
Signaling by CTNNB1 phospho-site mutants	15	5.41e-01	9.12e-02	7.01e-01
Signaling by GSK3beta mutants	15	5.41e-01	9.12e-02	7.01e-01
T41 mutants of beta-catenin aren’t phosphorylated	15	5.41e-01	9.12e-02	7.01e-01
Negative regulation of FGFR3 signaling	27	4.15e-01	9.05e-02	5.85e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	5.31e-01	9.04e-02	6.95e-01
DAP12 signaling	26	4.27e-01	9.00e-02	5.96e-01
Cell surface interactions at the vascular wall	105	1.11e-01	8.99e-02	2.18e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	4.11e-01	8.97e-02	5.81e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13	5.76e-01	-8.97e-02	7.27e-01
Signaling by VEGF	100	1.22e-01	8.94e-02	2.34e-01
NoRC negatively regulates rRNA expression	68	2.03e-01	8.92e-02	3.44e-01
Signaling by Retinoic Acid	38	3.41e-01	8.92e-02	5.09e-01
SUMOylation of intracellular receptors	28	4.14e-01	8.91e-02	5.85e-01
HCMV Infection	106	1.15e-01	8.86e-02	2.25e-01
Peroxisomal lipid metabolism	28	4.18e-01	8.85e-02	5.87e-01
ERK/MAPK targets	22	4.73e-01	-8.83e-02	6.39e-01
PI Metabolism	78	1.80e-01	-8.79e-02	3.11e-01
FCERI mediated MAPK activation	29	4.14e-01	8.76e-02	5.84e-01
Intracellular signaling by second messengers	294	9.64e-03	8.76e-02	2.92e-02
Regulation of signaling by CBL	18	5.20e-01	-8.76e-02	6.84e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	6.01e-01	8.72e-02	7.48e-01
Regulation of TP53 Activity through Acetylation	29	4.16e-01	-8.72e-02	5.86e-01
Signaling by FGFR4 in disease	11	6.20e-01	8.63e-02	7.63e-01
Negative epigenetic regulation of rRNA expression	71	2.09e-01	8.62e-02	3.50e-01
MET activates RAS signaling	11	6.21e-01	8.61e-02	7.63e-01
Cytosolic iron-sulfur cluster assembly	13	5.93e-01	8.55e-02	7.42e-01
GRB2 events in ERBB2 signaling	16	5.54e-01	8.55e-02	7.11e-01
Circadian Clock	67	2.27e-01	-8.54e-02	3.72e-01
Surfactant metabolism	21	4.99e-01	-8.53e-02	6.64e-01
Cell-extracellular matrix interactions	16	5.56e-01	-8.50e-02	7.12e-01
PKA-mediated phosphorylation of CREB	18	5.35e-01	8.45e-02	6.98e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	95	1.54e-01	-8.45e-02	2.76e-01
O-linked glycosylation	102	1.41e-01	8.44e-02	2.59e-01
Regulation of actin dynamics for phagocytic cup formation	60	2.59e-01	8.43e-02	4.11e-01
IKK complex recruitment mediated by RIP1	22	4.96e-01	8.38e-02	6.62e-01
FGFRL1 modulation of FGFR1 signaling	12	6.16e-01	8.35e-02	7.61e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	4.37e-01	8.34e-02	6.04e-01
Trafficking of AMPA receptors	29	4.37e-01	8.34e-02	6.04e-01
SUMOylation	171	5.97e-02	8.34e-02	1.34e-01
Inwardly rectifying K+ channels	32	4.18e-01	8.27e-02	5.87e-01
Activation of RAC1	13	6.06e-01	8.26e-02	7.53e-01
Diseases associated with O-glycosylation of proteins	62	2.61e-01	8.26e-02	4.13e-01
RHOU GTPase cycle	40	3.68e-01	8.22e-02	5.41e-01
FGFR3 mutant receptor activation	10	6.55e-01	-8.17e-02	7.89e-01
Signaling by activated point mutants of FGFR3	10	6.55e-01	-8.17e-02	7.89e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	27	4.63e-01	-8.15e-02	6.31e-01
Signaling by ERBB2 KD Mutants	25	4.89e-01	8.00e-02	6.55e-01
RHO GTPase cycle	436	4.27e-03	7.97e-02	1.45e-02
RNA Polymerase I Promoter Escape	53	3.17e-01	7.95e-02	4.78e-01
Chemokine receptors bind chemokines	29	4.59e-01	7.95e-02	6.26e-01
MicroRNA (miRNA) biogenesis	24	5.01e-01	7.93e-02	6.66e-01
Signaling by RAF1 mutants	37	4.10e-01	7.83e-02	5.79e-01
Interleukin-37 signaling	21	5.36e-01	-7.81e-02	6.99e-01
Regulation of TP53 Activity through Association with Co-factors	12	6.42e-01	7.76e-02	7.77e-01
Ca2+ pathway	60	3.03e-01	-7.69e-02	4.64e-01
Ephrin signaling	19	5.63e-01	-7.67e-02	7.17e-01
rRNA processing in the mitochondrion	24	5.16e-01	-7.66e-02	6.79e-01
Downstream signal transduction	29	4.76e-01	-7.65e-02	6.41e-01
Beta-catenin phosphorylation cascade	17	5.86e-01	7.62e-02	7.36e-01
Nicotinamide salvaging	18	5.77e-01	7.60e-02	7.28e-01
Reproduction	94	2.05e-01	7.56e-02	3.45e-01
Regulation of insulin secretion	69	2.79e-01	7.53e-02	4.37e-01
PLC beta mediated events	46	3.77e-01	-7.52e-02	5.47e-01
Defective B3GALTL causes PpS	36	4.35e-01	-7.52e-02	6.03e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	95	2.10e-01	7.45e-02	3.50e-01
Toll Like Receptor 2 (TLR2) Cascade	95	2.10e-01	7.45e-02	3.50e-01
Toll Like Receptor TLR1:TLR2 Cascade	95	2.10e-01	7.45e-02	3.50e-01
Toll Like Receptor TLR6:TLR2 Cascade	95	2.10e-01	7.45e-02	3.50e-01
Negative regulation of FGFR2 signaling	31	4.74e-01	7.42e-02	6.40e-01
IRAK4 deficiency (TLR2/4)	15	6.19e-01	7.42e-02	7.63e-01
Biosynthesis of specialized proresolving mediators (SPMs)	15	6.21e-01	7.37e-02	7.63e-01
SLC transporter disorders	83	2.49e-01	7.32e-02	3.97e-01
SHC-mediated cascade:FGFR2	20	5.72e-01	7.31e-02	7.24e-01
FLT3 Signaling	36	4.49e-01	7.29e-02	6.16e-01
SLC-mediated transmembrane transport	205	7.54e-02	7.20e-02	1.61e-01
Downregulation of ERBB2 signaling	29	5.05e-01	7.16e-02	6.69e-01
HATs acetylate histones	101	2.17e-01	-7.10e-02	3.60e-01
Constitutive Signaling by Aberrant PI3K in Cancer	68	3.13e-01	7.08e-02	4.74e-01
Synthesis of PE	13	6.59e-01	-7.06e-02	7.92e-01
Oncogene Induced Senescence	31	4.97e-01	-7.05e-02	6.62e-01
SUMOylation of transcription factors	19	5.95e-01	7.04e-02	7.43e-01
Nonhomologous End-Joining (NHEJ)	43	4.25e-01	-7.03e-02	5.94e-01
Nitric oxide stimulates guanylate cyclase	18	6.08e-01	6.99e-02	7.53e-01
Effects of PIP2 hydrolysis	24	5.55e-01	-6.97e-02	7.11e-01
The NLRP3 inflammasome	15	6.42e-01	6.94e-02	7.77e-01
Signal Transduction	2215	6.18e-08	6.93e-02	6.05e-07
tRNA modification in the nucleus and cytosol	43	4.33e-01	6.90e-02	6.03e-01
Signaling by PDGF	53	3.86e-01	-6.88e-02	5.54e-01
Activated point mutants of FGFR2	14	6.57e-01	-6.86e-02	7.90e-01
Formation of apoptosome	11	6.94e-01	6.84e-02	8.23e-01
Regulation of the apoptosome activity	11	6.94e-01	6.84e-02	8.23e-01
Downregulation of TGF-beta receptor signaling	26	5.48e-01	6.80e-02	7.06e-01
Potential therapeutics for SARS	82	2.88e-01	6.79e-02	4.47e-01
Neurotransmitter receptors and postsynaptic signal transmission	163	1.35e-01	6.78e-02	2.51e-01
Tie2 Signaling	17	6.30e-01	6.75e-02	7.69e-01
Pre-NOTCH Processing in Golgi	18	6.20e-01	6.74e-02	7.63e-01
Acyl chain remodelling of PC	21	5.93e-01	-6.73e-02	7.42e-01
Role of phospholipids in phagocytosis	24	5.72e-01	-6.66e-02	7.24e-01
Post NMDA receptor activation events	58	3.82e-01	6.63e-02	5.51e-01
Signaling by NTRK3 (TRKC)	16	6.46e-01	-6.63e-02	7.82e-01
Aspartate and asparagine metabolism	10	7.17e-01	-6.62e-02	8.37e-01
Nephrin family interactions	21	6.00e-01	6.61e-02	7.47e-01
Nucleotide biosynthesis	12	6.93e-01	6.59e-02	8.23e-01
Transcriptional regulation of testis differentiation	11	7.06e-01	6.56e-02	8.30e-01
Interleukin receptor SHC signaling	22	5.95e-01	6.55e-02	7.43e-01
Molecules associated with elastic fibres	27	5.61e-01	6.47e-02	7.17e-01
NOD1/2 Signaling Pathway	32	5.28e-01	-6.45e-02	6.92e-01
DNA methylation	27	5.63e-01	-6.43e-02	7.17e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	85	3.06e-01	6.42e-02	4.67e-01
SUMO E3 ligases SUMOylate target proteins	165	1.59e-01	6.35e-02	2.83e-01
Growth hormone receptor signaling	20	6.24e-01	-6.34e-02	7.65e-01
RNA Polymerase III Abortive And Retractive Initiation	41	4.83e-01	6.33e-02	6.48e-01
RNA Polymerase III Transcription	41	4.83e-01	6.33e-02	6.48e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	6.53e-01	6.31e-02	7.88e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	26	5.78e-01	6.30e-02	7.28e-01
Ovarian tumor domain proteases	38	5.03e-01	-6.28e-02	6.68e-01
Tryptophan catabolism	13	6.96e-01	-6.25e-02	8.24e-01
Endogenous sterols	23	6.10e-01	-6.15e-02	7.55e-01
Cytochrome c-mediated apoptotic response	13	7.02e-01	6.12e-02	8.27e-01
Trafficking and processing of endosomal TLR	11	7.26e-01	6.10e-02	8.45e-01
Class B/2 (Secretin family receptors)	74	3.66e-01	6.08e-02	5.38e-01
Myogenesis	25	5.99e-01	6.07e-02	7.47e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	28	5.78e-01	-6.07e-02	7.28e-01
Stimuli-sensing channels	87	3.28e-01	-6.07e-02	4.93e-01
Carnitine metabolism	11	7.28e-01	-6.06e-02	8.46e-01
Defects in vitamin and cofactor metabolism	21	6.33e-01	6.01e-02	7.73e-01
Other interleukin signaling	23	6.23e-01	-5.93e-02	7.64e-01
Sema4D in semaphorin signaling	24	6.16e-01	5.91e-02	7.61e-01
Regulation of TP53 Expression and Degradation	36	5.44e-01	5.84e-02	7.03e-01
CD28 dependent PI3K/Akt signaling	19	6.61e-01	-5.80e-02	7.94e-01
Leishmania infection	196	1.63e-01	5.77e-02	2.89e-01
CLEC7A (Dectin-1) induces NFAT activation	11	7.41e-01	-5.76e-02	8.52e-01
Collagen formation	87	3.53e-01	-5.76e-02	5.22e-01
MTOR signalling	40	5.29e-01	5.75e-02	6.93e-01
Integrin signaling	25	6.24e-01	-5.67e-02	7.65e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	13	7.24e-01	5.65e-02	8.44e-01
Signaling by FGFR3	38	5.48e-01	5.63e-02	7.06e-01
Prolonged ERK activation events	14	7.17e-01	5.59e-02	8.37e-01
Packaging Of Telomere Ends	25	6.29e-01	-5.58e-02	7.69e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	38	5.54e-01	-5.55e-02	7.11e-01
Striated Muscle Contraction	27	6.19e-01	-5.53e-02	7.63e-01
Caspase activation via Death Receptors in the presence of ligand	15	7.11e-01	5.53e-02	8.34e-01
Signaling by cytosolic FGFR1 fusion mutants	18	6.86e-01	-5.50e-02	8.18e-01
Signaling by FGFR4	38	5.60e-01	5.47e-02	7.16e-01
Frs2-mediated activation	12	7.44e-01	5.44e-02	8.54e-01
SHC-mediated cascade:FGFR1	19	6.82e-01	-5.44e-02	8.13e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	4.27e-01	5.41e-02	5.96e-01
Transcriptional Regulation by MECP2	57	4.80e-01	5.40e-02	6.46e-01
Biological oxidations	165	2.32e-01	5.38e-02	3.79e-01
Synthesis of PIPs at the early endosome membrane	16	7.10e-01	-5.37e-02	8.33e-01
MyD88 cascade initiated on plasma membrane	81	4.05e-01	5.35e-02	5.74e-01
Toll Like Receptor 10 (TLR10) Cascade	81	4.05e-01	5.35e-02	5.74e-01
Toll Like Receptor 5 (TLR5) Cascade	81	4.05e-01	5.35e-02	5.74e-01
Metabolism of amine-derived hormones	13	7.39e-01	5.33e-02	8.51e-01
G alpha (q) signalling events	163	2.45e-01	-5.27e-02	3.93e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	21	6.77e-01	-5.26e-02	8.09e-01
Signaling by KIT in disease	19	6.92e-01	-5.25e-02	8.23e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	6.92e-01	-5.25e-02	8.23e-01
The phototransduction cascade	27	6.38e-01	5.23e-02	7.77e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	7.35e-01	5.23e-02	8.50e-01
Regulation of TP53 Degradation	35	5.93e-01	5.22e-02	7.42e-01
Activation of the AP-1 family of transcription factors	10	7.75e-01	-5.21e-02	8.72e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	86	4.04e-01	5.21e-02	5.74e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	95	3.81e-01	5.20e-02	5.50e-01
HCMV Early Events	82	4.17e-01	5.18e-02	5.87e-01
Transcriptional regulation of white adipocyte differentiation	82	4.19e-01	5.16e-02	5.88e-01
FGFR4 ligand binding and activation	11	7.68e-01	-5.13e-02	8.67e-01
Semaphorin interactions	60	4.93e-01	5.12e-02	6.59e-01
Ras activation upon Ca2+ influx through NMDA receptor	20	6.97e-01	-5.02e-02	8.24e-01
PI3K/AKT Signaling in Cancer	95	3.99e-01	5.01e-02	5.67e-01
DNA Damage/Telomere Stress Induced Senescence	52	5.33e-01	-4.99e-02	6.97e-01
Glutathione synthesis and recycling	12	7.66e-01	4.97e-02	8.67e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	51	5.43e-01	-4.92e-02	7.02e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	6.52e-01	4.92e-02	7.88e-01
TICAM1-dependent activation of IRF3/IRF7	12	7.70e-01	4.87e-02	8.68e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	11	7.81e-01	4.83e-02	8.77e-01
Diseases of hemostasis	11	7.81e-01	4.83e-02	8.77e-01
Glycogen metabolism	26	6.71e-01	4.82e-02	8.03e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	6.30e-01	4.78e-02	7.69e-01
FGFR2c ligand binding and activation	10	7.95e-01	-4.75e-02	8.81e-01
RNA Polymerase I Transcription Initiation	47	5.75e-01	4.72e-02	7.27e-01
Prolactin receptor signaling	11	7.86e-01	-4.72e-02	8.79e-01
Anti-inflammatory response favouring Leishmania parasite infection	114	3.85e-01	4.71e-02	5.53e-01
Leishmania parasite growth and survival	114	3.85e-01	4.71e-02	5.53e-01
SUMOylation of chromatin organization proteins	57	5.43e-01	4.65e-02	7.02e-01
Regulation of FOXO transcriptional activity by acetylation	10	7.99e-01	-4.64e-02	8.84e-01
VEGFR2 mediated cell proliferation	19	7.29e-01	4.58e-02	8.46e-01
FGFR3 ligand binding and activation	11	7.93e-01	-4.56e-02	8.80e-01
FGFR3c ligand binding and activation	11	7.93e-01	-4.56e-02	8.80e-01
Deadenylation of mRNA	22	7.13e-01	4.53e-02	8.35e-01
MyD88 dependent cascade initiated on endosome	87	4.68e-01	4.50e-02	6.34e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	87	4.68e-01	4.50e-02	6.34e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	7.79e-01	4.49e-02	8.76e-01
Signaling by FLT3 fusion proteins	19	7.36e-01	4.47e-02	8.50e-01
MyD88-independent TLR4 cascade	94	4.54e-01	4.47e-02	6.20e-01
TRIF(TICAM1)-mediated TLR4 signaling	94	4.54e-01	4.47e-02	6.20e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	7.43e-01	4.47e-02	8.53e-01
Assembly of active LPL and LIPC lipase complexes	14	7.72e-01	4.47e-02	8.70e-01
Receptor Mediated Mitophagy	11	7.98e-01	4.45e-02	8.83e-01
Cytochrome P450 - arranged by substrate type	49	5.90e-01	4.45e-02	7.40e-01
Termination of O-glycan biosynthesis	19	7.38e-01	4.43e-02	8.50e-01
Interleukin-17 signaling	68	5.28e-01	4.43e-02	6.92e-01
Dectin-2 family	18	7.48e-01	4.37e-02	8.56e-01
RHOBTB3 ATPase cycle	10	8.11e-01	-4.36e-02	8.91e-01
Formation of the beta-catenin:TCF transactivating complex	53	5.83e-01	-4.36e-02	7.33e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	8.11e-01	4.36e-02	8.91e-01
PI3K events in ERBB2 signaling	16	7.63e-01	4.36e-02	8.65e-01
B-WICH complex positively regulates rRNA expression	53	5.85e-01	4.34e-02	7.35e-01
Adrenaline,noradrenaline inhibits insulin secretion	26	7.02e-01	4.33e-02	8.27e-01
Transport of Mature Transcript to Cytoplasm	81	5.01e-01	4.32e-02	6.66e-01
FRS-mediated FGFR4 signaling	19	7.45e-01	4.31e-02	8.54e-01
Negative regulation of the PI3K/AKT network	102	4.56e-01	4.27e-02	6.23e-01
Nuclear Events (kinase and transcription factor activation)	62	5.62e-01	-4.25e-02	7.17e-01
Signaling by ERBB2 in Cancer	26	7.13e-01	4.17e-02	8.35e-01
Inactivation, recovery and regulation of the phototransduction cascade	26	7.14e-01	4.15e-02	8.35e-01
Oxidative Stress Induced Senescence	83	5.13e-01	-4.15e-02	6.77e-01
FGFR2 ligand binding and activation	15	7.85e-01	-4.08e-02	8.78e-01
Sensory processing of sound by outer hair cells of the cochlea	44	6.40e-01	4.07e-02	7.77e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	6.37e-01	4.07e-02	7.76e-01
CASP8 activity is inhibited	10	8.25e-01	4.03e-02	8.99e-01
Dimerization of procaspase-8	10	8.25e-01	4.03e-02	8.99e-01
Regulation by c-FLIP	10	8.25e-01	4.03e-02	8.99e-01
RHOC GTPase cycle	72	5.55e-01	4.02e-02	7.11e-01
ERKs are inactivated	13	8.03e-01	4.00e-02	8.85e-01
Inflammasomes	20	7.59e-01	-3.96e-02	8.64e-01
Transmission across Chemical Synapses	225	3.11e-01	3.92e-02	4.73e-01
NOTCH1 Intracellular Domain Regulates Transcription	48	6.39e-01	3.92e-02	7.77e-01
Opioid Signalling	82	5.40e-01	3.91e-02	7.01e-01
FCERI mediated Ca+2 mobilization	28	7.22e-01	3.89e-02	8.42e-01
Ion transport by P-type ATPases	49	6.39e-01	3.87e-02	7.77e-01
Muscle contraction	166	3.90e-01	3.86e-02	5.59e-01
ERBB2 Activates PTK6 Signaling	13	8.11e-01	-3.82e-02	8.91e-01
Regulation of IFNA signaling	13	8.12e-01	-3.82e-02	8.91e-01
Negative regulators of DDX58/IFIH1 signaling	35	6.96e-01	-3.82e-02	8.24e-01
Synthesis of PIPs at the Golgi membrane	16	7.92e-01	3.81e-02	8.80e-01
Signaling by FGFR3 in disease	20	7.68e-01	-3.80e-02	8.67e-01
Signaling by FGFR3 point mutants in cancer	20	7.68e-01	-3.80e-02	8.67e-01
Toll Like Receptor 4 (TLR4) Cascade	123	4.67e-01	3.80e-02	6.34e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	6.94e-01	3.79e-02	8.23e-01
p75NTR signals via NF-kB	16	7.93e-01	-3.79e-02	8.80e-01
PI-3K cascade:FGFR4	17	7.88e-01	3.76e-02	8.80e-01
ECM proteoglycans	47	6.57e-01	-3.74e-02	7.91e-01
MAP kinase activation	63	6.12e-01	3.69e-02	7.58e-01
Glycerophospholipid biosynthesis	116	4.93e-01	3.68e-02	6.59e-01
Toll Like Receptor 9 (TLR9) Cascade	91	5.45e-01	3.67e-02	7.04e-01
Integrin cell surface interactions	59	6.27e-01	3.66e-02	7.68e-01
Physiological factors	11	8.34e-01	-3.66e-02	8.99e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	7.29e-01	3.65e-02	8.46e-01
Signaling by TGFB family members	98	5.37e-01	3.61e-02	7.00e-01
tRNA Aminoacylation	42	6.90e-01	-3.56e-02	8.22e-01
Processing of SMDT1	15	8.13e-01	3.52e-02	8.91e-01
SUMOylation of DNA methylation proteins	16	8.08e-01	-3.52e-02	8.89e-01
Cytosolic sulfonation of small molecules	22	7.76e-01	3.51e-02	8.72e-01
CD28 co-stimulation	30	7.41e-01	3.49e-02	8.52e-01
PI3K Cascade	41	6.99e-01	-3.48e-02	8.25e-01
G alpha (s) signalling events	97	5.55e-01	3.47e-02	7.11e-01
Negative regulation of FGFR1 signaling	31	7.45e-01	-3.37e-02	8.54e-01
HCMV Late Events	78	6.07e-01	3.37e-02	7.53e-01
RIPK1-mediated regulated necrosis	27	7.63e-01	3.35e-02	8.65e-01
Regulation of necroptotic cell death	27	7.63e-01	3.35e-02	8.65e-01
NCAM1 interactions	36	7.28e-01	-3.34e-02	8.46e-01
RNA Polymerase III Transcription Termination	23	7.82e-01	3.33e-02	8.77e-01
Nuclear events stimulated by ALK signaling in cancer	19	8.03e-01	3.31e-02	8.85e-01
Cytosolic sensors of pathogen-associated DNA	62	6.54e-01	-3.29e-02	7.89e-01
Transcriptional regulation of pluripotent stem cells	31	7.53e-01	3.27e-02	8.58e-01
ADP signalling through P2Y purinoceptor 1	23	7.87e-01	3.25e-02	8.79e-01
Interferon alpha/beta signaling	58	6.69e-01	3.24e-02	8.02e-01
DCC mediated attractive signaling	14	8.34e-01	3.24e-02	8.99e-01
Signaling by WNT in cancer	33	7.48e-01	-3.23e-02	8.56e-01
APC truncation mutants have impaired AXIN binding	14	8.36e-01	3.20e-02	8.99e-01
AXIN missense mutants destabilize the destruction complex	14	8.36e-01	3.20e-02	8.99e-01
Signaling by AMER1 mutants	14	8.36e-01	3.20e-02	8.99e-01
Signaling by APC mutants	14	8.36e-01	3.20e-02	8.99e-01
Signaling by AXIN mutants	14	8.36e-01	3.20e-02	8.99e-01
Truncations of AMER1 destabilize the destruction complex	14	8.36e-01	3.20e-02	8.99e-01
Signaling by Erythropoietin	25	7.83e-01	-3.19e-02	8.77e-01
Toll-like Receptor Cascades	141	5.13e-01	3.19e-02	6.77e-01
Dermatan sulfate biosynthesis	11	8.55e-01	3.17e-02	9.11e-01
RHOBTB1 GTPase cycle	23	7.93e-01	3.16e-02	8.80e-01
Neurotransmitter release cycle	48	7.06e-01	-3.15e-02	8.30e-01
FRS-mediated FGFR3 signaling	18	8.17e-01	3.14e-02	8.94e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	13	8.46e-01	-3.11e-02	9.08e-01
Triglyceride biosynthesis	10	8.67e-01	-3.07e-02	9.19e-01
Signaling by SCF-KIT	41	7.34e-01	-3.06e-02	8.50e-01
Signaling by ALK fusions and activated point mutants	55	6.98e-01	-3.03e-02	8.24e-01
Signaling by ALK in cancer	55	6.98e-01	-3.03e-02	8.24e-01
DAG and IP3 signaling	38	7.50e-01	-2.99e-02	8.56e-01
Na+/Cl- dependent neurotransmitter transporters	12	8.58e-01	-2.99e-02	9.13e-01
p75 NTR receptor-mediated signalling	96	6.13e-01	2.99e-02	7.58e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	7.92e-01	2.98e-02	8.80e-01
Keratan sulfate biosynthesis	24	8.01e-01	2.97e-02	8.85e-01
Interferon gamma signaling	83	6.41e-01	2.96e-02	7.77e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	26	7.96e-01	2.93e-02	8.82e-01
Visual phototransduction	75	6.65e-01	2.89e-02	7.97e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	51	7.26e-01	-2.84e-02	8.45e-01
activated TAK1 mediates p38 MAPK activation	19	8.31e-01	2.83e-02	8.99e-01
Death Receptor Signalling	139	5.72e-01	-2.77e-02	7.24e-01
Signalling to RAS	20	8.34e-01	-2.71e-02	8.99e-01
CTLA4 inhibitory signaling	17	8.48e-01	-2.69e-02	9.08e-01
Sulfur amino acid metabolism	26	8.13e-01	2.69e-02	8.91e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	67	7.06e-01	-2.67e-02	8.30e-01
Heme degradation	11	8.80e-01	-2.63e-02	9.30e-01
RMTs methylate histone arginines	44	7.63e-01	2.63e-02	8.65e-01
Epigenetic regulation of gene expression	110	6.34e-01	2.62e-02	7.74e-01
EPHB-mediated forward signaling	34	7.93e-01	2.60e-02	8.80e-01
TNFs bind their physiological receptors	21	8.37e-01	-2.59e-02	8.99e-01
RET signaling	37	7.86e-01	-2.58e-02	8.79e-01
Synthesis of PIPs at the plasma membrane	50	7.53e-01	-2.57e-02	8.58e-01
SIRT1 negatively regulates rRNA expression	30	8.09e-01	-2.56e-02	8.90e-01
FCGR3A-mediated phagocytosis	58	7.37e-01	2.55e-02	8.50e-01
Leishmania phagocytosis	58	7.37e-01	2.55e-02	8.50e-01
Parasite infection	58	7.37e-01	2.55e-02	8.50e-01
GABA synthesis, release, reuptake and degradation	18	8.53e-01	2.52e-02	9.10e-01
Class A/1 (Rhodopsin-like receptors)	196	5.47e-01	-2.49e-02	7.05e-01
Signaling by NTRK2 (TRKB)	24	8.33e-01	-2.48e-02	8.99e-01
PECAM1 interactions	11	8.87e-01	2.48e-02	9.34e-01
RUNX3 regulates NOTCH signaling	14	8.74e-01	-2.46e-02	9.25e-01
PI-3K cascade:FGFR3	16	8.67e-01	2.42e-02	9.19e-01
Beta-oxidation of very long chain fatty acids	11	8.91e-01	2.38e-02	9.36e-01
NGF-stimulated transcription	40	8.00e-01	-2.31e-02	8.84e-01
Acyl chain remodelling of PE	22	8.54e-01	2.27e-02	9.10e-01
Signaling by NTRK1 (TRKA)	115	6.76e-01	2.26e-02	8.08e-01
Positive epigenetic regulation of rRNA expression	68	7.49e-01	2.25e-02	8.56e-01
Membrane binding and targetting of GAG proteins	14	8.85e-01	2.24e-02	9.33e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	8.85e-01	2.24e-02	9.33e-01
Toll Like Receptor 3 (TLR3) Cascade	90	7.16e-01	2.22e-02	8.36e-01
Regulation of PTEN gene transcription	61	7.66e-01	2.20e-02	8.67e-01
Interleukin-35 Signalling	12	8.96e-01	2.18e-02	9.38e-01
Signaling by ALK	26	8.51e-01	2.13e-02	9.10e-01
Activation of NMDA receptors and postsynaptic events	71	7.60e-01	2.09e-02	8.64e-01
Cleavage of the damaged pyrimidine	34	8.33e-01	2.08e-02	8.99e-01
Depyrimidination	34	8.33e-01	2.08e-02	8.99e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	34	8.33e-01	2.08e-02	8.99e-01
Sema4D induced cell migration and growth-cone collapse	20	8.72e-01	2.08e-02	9.24e-01
Generic Transcription Pathway	1144	2.34e-01	-2.08e-02	3.80e-01
p75NTR recruits signalling complexes	13	8.99e-01	2.04e-02	9.39e-01
Base-Excision Repair, AP Site Formation	36	8.33e-01	2.04e-02	8.99e-01
p38MAPK events	13	9.02e-01	-1.96e-02	9.41e-01
Sialic acid metabolism	30	8.53e-01	-1.95e-02	9.10e-01
Regulation of MECP2 expression and activity	31	8.53e-01	-1.92e-02	9.10e-01
FRS-mediated FGFR2 signaling	22	8.76e-01	1.92e-02	9.27e-01
IRS-mediated signalling	45	8.24e-01	-1.91e-02	8.99e-01
CaMK IV-mediated phosphorylation of CREB	10	9.18e-01	1.87e-02	9.51e-01
RHOB GTPase cycle	69	7.89e-01	1.86e-02	8.80e-01
Fertilization	17	8.94e-01	-1.86e-02	9.38e-01
Interleukin-2 family signaling	36	8.48e-01	-1.85e-02	9.08e-01
Interleukin-2 signaling	10	9.20e-01	-1.84e-02	9.51e-01
RHOV GTPase cycle	37	8.49e-01	1.80e-02	9.09e-01
Gene Silencing by RNA	98	7.59e-01	1.79e-02	8.64e-01
Peptide ligand-binding receptors	113	7.44e-01	1.78e-02	8.54e-01
L1CAM interactions	93	7.67e-01	1.77e-02	8.67e-01
Pre-NOTCH Expression and Processing	71	7.97e-01	-1.77e-02	8.82e-01
Ion channel transport	157	7.03e-01	1.76e-02	8.27e-01
Signalling to ERKs	33	8.63e-01	1.74e-02	9.18e-01
Signal regulatory protein family interactions	11	9.21e-01	1.73e-02	9.51e-01
G-protein mediated events	50	8.36e-01	-1.70e-02	8.99e-01
Downstream signaling of activated FGFR4	24	8.88e-01	1.66e-02	9.34e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	9.03e-01	1.66e-02	9.41e-01
RNA Polymerase I Promoter Clearance	72	8.17e-01	1.58e-02	8.93e-01
RNA Polymerase I Transcription	72	8.17e-01	1.58e-02	8.93e-01
GPCR ligand binding	285	6.48e-01	-1.57e-02	7.83e-01
CD209 (DC-SIGN) signaling	20	9.03e-01	-1.57e-02	9.41e-01
Extracellular matrix organization	263	6.62e-01	-1.56e-02	7.95e-01
Plasma lipoprotein remodeling	24	8.95e-01	-1.56e-02	9.38e-01
Assembly of the ORC complex at the origin of replication	31	8.81e-01	1.55e-02	9.30e-01
Xenobiotics	16	9.17e-01	1.51e-02	9.50e-01
Signaling by GPCR	500	5.79e-01	-1.45e-02	7.28e-01
Fcgamma receptor (FCGR) dependent phagocytosis	85	8.18e-01	1.44e-02	8.94e-01
Insulin receptor signalling cascade	50	8.63e-01	-1.41e-02	9.18e-01
Biosynthesis of DHA-derived SPMs	14	9.28e-01	1.39e-02	9.57e-01
Olfactory Signaling Pathway	24	9.07e-01	-1.38e-02	9.44e-01
RAC1 GTPase cycle	178	7.51e-01	1.38e-02	8.57e-01
G alpha (i) signalling events	207	7.37e-01	1.36e-02	8.50e-01
Assembly Of The HIV Virion	16	9.31e-01	1.24e-02	9.59e-01
PI-3K cascade:FGFR2	20	9.25e-01	1.22e-02	9.54e-01
MET activates RAP1 and RAC1	11	9.45e-01	-1.19e-02	9.69e-01
VxPx cargo-targeting to cilium	19	9.29e-01	-1.17e-02	9.57e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	9.10e-01	-1.17e-02	9.46e-01
Potassium Channels	86	8.52e-01	-1.16e-02	9.10e-01
GPCR downstream signalling	442	6.77e-01	-1.15e-02	8.09e-01
Free fatty acids regulate insulin secretion	10	9.50e-01	-1.15e-02	9.70e-01
Cardiac conduction	112	8.37e-01	-1.13e-02	8.99e-01
Degradation of cysteine and homocysteine	12	9.46e-01	-1.12e-02	9.69e-01
PI3K events in ERBB4 signaling	10	9.51e-01	-1.12e-02	9.70e-01
Ca-dependent events	34	9.11e-01	-1.11e-02	9.46e-01
IGF1R signaling cascade	49	8.95e-01	1.09e-02	9.38e-01
Formation of Fibrin Clot (Clotting Cascade)	27	9.24e-01	1.06e-02	9.53e-01
NF-kB is activated and signals survival	13	9.48e-01	1.05e-02	9.70e-01
NOTCH2 intracellular domain regulates transcription	12	9.51e-01	1.02e-02	9.70e-01
Phase I - Functionalization of compounds	82	8.74e-01	-1.01e-02	9.25e-01
Alpha-protein kinase 1 signaling pathway	11	9.54e-01	-9.99e-03	9.71e-01
TRAF6 mediated NF-kB activation	23	9.35e-01	9.75e-03	9.62e-01
Maturation of nucleoprotein	11	9.55e-01	-9.73e-03	9.71e-01
Phospholipid metabolism	193	8.20e-01	-9.50e-03	8.95e-01
CDC42 GTPase cycle	153	8.42e-01	-9.33e-03	9.04e-01
Activation of HOX genes during differentiation	82	8.87e-01	-9.05e-03	9.34e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	82	8.87e-01	-9.05e-03	9.34e-01
DNA Double Strand Break Response	52	9.11e-01	-8.98e-03	9.46e-01
IRS-related events triggered by IGF1R	48	9.16e-01	-8.80e-03	9.50e-01
Acyl chain remodelling of PG	12	9.58e-01	-8.72e-03	9.73e-01
Cell death signalling via NRAGE, NRIF and NADE	76	8.98e-01	8.53e-03	9.39e-01
Nuclear Receptor transcription pathway	48	9.21e-01	-8.25e-03	9.51e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	28	9.41e-01	-8.13e-03	9.65e-01
CaM pathway	32	9.37e-01	8.07e-03	9.62e-01
Calmodulin induced events	32	9.37e-01	8.07e-03	9.62e-01
mRNA 3’-end processing	56	9.17e-01	8.01e-03	9.51e-01
Keratinization	58	9.20e-01	-7.66e-03	9.51e-01
Rab regulation of trafficking	120	8.92e-01	7.17e-03	9.37e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	9.69e-01	-6.70e-03	9.83e-01
Cleavage of the damaged purine	29	9.50e-01	6.69e-03	9.70e-01
Depurination	29	9.50e-01	6.69e-03	9.70e-01
Recognition and association of DNA glycosylase with site containing an affected purine	29	9.50e-01	6.69e-03	9.70e-01
TP53 Regulates Transcription of Cell Death Genes	43	9.41e-01	6.47e-03	9.65e-01
Downstream signaling of activated FGFR3	23	9.58e-01	6.32e-03	9.73e-01
Signaling by NTRKs	133	9.03e-01	-6.13e-03	9.41e-01
PRC2 methylates histones and DNA	35	9.54e-01	5.65e-03	9.71e-01
Cellular Senescence	153	9.12e-01	-5.15e-03	9.47e-01
Meiotic synapsis	50	9.55e-01	-4.56e-03	9.71e-01
Mitochondrial calcium ion transport	22	9.73e-01	4.21e-03	9.85e-01
Neuronal System	342	8.99e-01	-3.99e-03	9.39e-01
Acetylcholine binding and downstream events	11	9.84e-01	-3.54e-03	9.91e-01
Postsynaptic nicotinic acetylcholine receptors	11	9.84e-01	-3.54e-03	9.91e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	39	9.71e-01	-3.42e-03	9.84e-01
Cell recruitment (pro-inflammatory response)	23	9.78e-01	3.39e-03	9.87e-01
Purinergic signaling in leishmaniasis infection	23	9.78e-01	3.39e-03	9.87e-01
Gene expression (Transcription)	1398	8.65e-01	-2.69e-03	9.19e-01
Acyl chain remodelling of PS	17	9.85e-01	-2.64e-03	9.91e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	50	9.75e-01	-2.56e-03	9.86e-01
Elevation of cytosolic Ca2+ levels	13	9.88e-01	2.32e-03	9.93e-01
Regulation of TP53 Activity through Methylation	19	9.86e-01	-2.32e-03	9.91e-01
G alpha (12/13) signalling events	77	9.79e-01	-1.76e-03	9.87e-01
Sensory Perception	184	9.73e-01	-1.45e-03	9.85e-01
Pre-NOTCH Transcription and Translation	55	9.86e-01	1.35e-03	9.91e-01
Activation of kainate receptors upon glutamate binding	28	9.90e-01	-1.33e-03	9.94e-01
Notch-HLH transcription pathway	28	9.91e-01	-1.29e-03	9.94e-01
Regulation of innate immune responses to cytosolic DNA	14	9.93e-01	-1.29e-03	9.96e-01
Platelet Adhesion to exposed collagen	11	9.94e-01	-1.23e-03	9.96e-01
CRMPs in Sema3A signaling	16	9.95e-01	-9.81e-04	9.96e-01
RNA Polymerase II Transcription	1262	9.74e-01	-5.39e-04	9.85e-01
Signaling by FGFR1	48	9.98e-01	-1.58e-04	9.99e-01
Downstream signaling of activated FGFR2	27	1.00e+00	6.12e-05	1.00e+00

---

Detailed Gene set reports

Unwinding of DNA

Unwinding of DNA

	1427
set	Unwinding of DNA
setSize	12
pANOVA	1.01e-05
s.dist	0.736
p.adjustANOVA	6.79e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GINS2	12599
MCM2	12140
MCM4	12113
GINS4	11992
GINS1	11681
CDC45	11329
MCM3	11283
MCM5	10865
MCM8	10355
GINS3	10094
MCM6	9193
MCM7	-13907

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GINS2	12599
MCM2	12140
MCM4	12113
GINS4	11992
GINS1	11681
CDC45	11329
MCM3	11283
MCM5	10865
MCM8	10355
GINS3	10094
MCM6	9193
MCM7	-13907

---

Leading Strand Synthesis

Leading Strand Synthesis

	640
set	Leading Strand Synthesis
setSize	14
pANOVA	2.89e-06
s.dist	0.722
p.adjustANOVA	2.17e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFC4	12293
RFC5	12157
RFC3	11888
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
RFC2	10552
POLD4	10381
POLD2	10201
POLD1	7223
POLA1	5953
RFC1	5243
POLD3	-6136

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFC4	12293
RFC5	12157
RFC3	11888
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
RFC2	10552
POLD4	10381
POLD2	10201
POLD1	7223
POLA1	5953
RFC1	5243
POLD3	-6136

---

Polymerase switching

Polymerase switching

	893
set	Polymerase switching
setSize	14
pANOVA	2.89e-06
s.dist	0.722
p.adjustANOVA	2.17e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFC4	12293
RFC5	12157
RFC3	11888
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
RFC2	10552
POLD4	10381
POLD2	10201
POLD1	7223
POLA1	5953
RFC1	5243
POLD3	-6136

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFC4	12293
RFC5	12157
RFC3	11888
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
RFC2	10552
POLD4	10381
POLD2	10201
POLD1	7223
POLA1	5953
RFC1	5243
POLD3	-6136

---

Response to metal ions

Response to metal ions

	1102
set	Response to metal ions
setSize	10
pANOVA	7.78e-05
s.dist	0.721
p.adjustANOVA	0.000452

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT2A	12726
MT1X	12642
CSRP1	11811
MT1A	11657
MT1E	11245
MT1M	8775
SNCB	8652
MT1F	5248
MTF1	4807
MT1G	1913

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT2A	12726
MT1X	12642
CSRP1	11811
MT1A	11657
MT1E	11245
MT1M	8775
SNCB	8652
MT1F	5248
MTF1	4807
MT1G	1913

---

G1/S-Specific Transcription

G1/S-Specific Transcription

	458
set	G1/S-Specific Transcription
setSize	29
pANOVA	1.35e-10
s.dist	0.689
p.adjustANOVA	1.79e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RRM2	12689
DHFR	12674
CDK1	12520
TYMS	12399
TK1	12261
TFDP2	12250
CDT1	12021
CDC6	11743
ORC1	11656
TFDP1	11600
PCNA	11595
CDC45	11329
E2F6	10776
CDC25A	10302
E2F1	10289
FBXO5	10008
RBBP4	9908
RBL1	9200
LIN52	8996
LIN9	7328

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RRM2	12689
DHFR	12674
CDK1	12520
TYMS	12399
TK1	12261
TFDP2	12250
CDT1	12021
CDC6	11743
ORC1	11656
TFDP1	11600
PCNA	11595
CDC45	11329
E2F6	10776
CDC25A	10302
E2F1	10289
FBXO5	10008
RBBP4	9908
RBL1	9200
LIN52	8996
LIN9	7328
E2F4	7326
LIN54	6601
CCNA1	6154
CCNE1	5969
POLA1	5953
HDAC1	4759
E2F5	1156
RBL2	-1061
LIN37	-12099

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	216
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	7.92e-05
s.dist	0.687
p.adjustANOVA	0.000457

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCNB2	12588
CDK1	12520
NCAPG	12491
CCNB1	12183
NCAPD2	11991
SMC4	11970
NCAPH	11733
SMC2	8585
CSNK2A1	7686
CSNK2B	1532
CSNK2A2	-10004

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCNB2	12588
CDK1	12520
NCAPG	12491
CCNB1	12183
NCAPD2	11991
SMC4	11970
NCAPH	11733
SMC2	8585
CSNK2A1	7686
CSNK2B	1532
CSNK2A2	-10004

---

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

	1345
set	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
setSize	10
pANOVA	0.000231
s.dist	0.672
p.adjustANOVA	0.00112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DHFR	12674
HSP90AA1	12629
GCHFR	12481
CALM1	12384
GCH1	11018
SPR	10281
PTS	8026
PRKG2	5985
AKT1	-942
NOS3	-1756

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DHFR	12674
HSP90AA1	12629
GCHFR	12481
CALM1	12384
GCH1	11018
SPR	10281
PTS	8026
PRKG2	5985
AKT1	-942
NOS3	-1756

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

	423
set	Formation of ATP by chemiosmotic coupling
setSize	18
pANOVA	9.15e-07
s.dist	0.668
p.adjustANOVA	7.48e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5MC1	12573
ATP5MC3	11518
ATP5PB	11353
ATP5PF	11264
ATP5F1E	11110
DMAC2L	10638
ATP5MG	10628
ATP5F1A	9986
ATP5F1B	9845
ATP5F1C	9306
ATP5MC2	8959
ATP5PD	8937
ATP5PO	7206
ATP5F1D	5870
ATP5MF	4075
ATP5ME	2212
MT-ATP8	2186
MT-ATP6	266

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5MC1	12573
ATP5MC3	11518
ATP5PB	11353
ATP5PF	11264
ATP5F1E	11110
DMAC2L	10638
ATP5MG	10628
ATP5F1A	9986
ATP5F1B	9845
ATP5F1C	9306
ATP5MC2	8959
ATP5PD	8937
ATP5PO	7206
ATP5F1D	5870
ATP5MF	4075
ATP5ME	2212
MT-ATP8	2186
MT-ATP6	266

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

	1130
set	SLBP independent Processing of Histone Pre-mRNAs
setSize	10
pANOVA	0.000322
s.dist	0.657
p.adjustANOVA	0.0015

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNRPG	12404
NCBP2	12178
SNRPE	11802
SNRPB	10044
LSM10	9224
SNRPF	9080
NCBP1	8822
SNRPD3	7705
LSM11	3127
ZNF473	-3728

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNRPG	12404
NCBP2	12178
SNRPE	11802
SNRPB	10044
LSM10	9224
SNRPF	9080
NCBP1	8822
SNRPD3	7705
LSM11	3127
ZNF473	-3728

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	1129
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.000169
s.dist	0.655
p.adjustANOVA	0.000875

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNRPG	12404
NCBP2	12178
SNRPE	11802
SNRPB	10044
LSM10	9224
SNRPF	9080
NCBP1	8822
SLBP	7761
SNRPD3	7705
LSM11	3127
ZNF473	-3728

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNRPG	12404
NCBP2	12178
SNRPE	11802
SNRPB	10044
LSM10	9224
SNRPF	9080
NCBP1	8822
SLBP	7761
SNRPD3	7705
LSM11	3127
ZNF473	-3728

---

DNA strand elongation

DNA strand elongation

	260
set	DNA strand elongation
setSize	32
pANOVA	1.49e-10
s.dist	0.654
p.adjustANOVA	1.97e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GINS2	12599
RPA3	12466
RFC4	12293
RFC5	12157
MCM2	12140
MCM4	12113
FEN1	11996
GINS4	11992
RFC3	11888
GINS1	11681
POLA2	11680
PCNA	11595
PRIM1	11591
CDC45	11329
MCM3	11283
MCM5	10865
PRIM2	10724
RFC2	10552
POLD4	10381
MCM8	10355

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GINS2	12599
RPA3	12466
RFC4	12293
RFC5	12157
MCM2	12140
MCM4	12113
FEN1	11996
GINS4	11992
RFC3	11888
GINS1	11681
POLA2	11680
PCNA	11595
PRIM1	11591
CDC45	11329
MCM3	11283
MCM5	10865
PRIM2	10724
RFC2	10552
POLD4	10381
MCM8	10355
POLD2	10201
GINS3	10094
RPA2	9854
MCM6	9193
POLD1	7223
POLA1	5953
RFC1	5243
RPA1	3220
POLD3	-6136
LIG1	-6204
DNA2	-9757
MCM7	-13907

---

Translesion synthesis by REV1

Translesion synthesis by REV1

	1397
set	Translesion synthesis by REV1
setSize	16
pANOVA	9.42e-06
s.dist	0.64
p.adjustANOVA	6.4e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
RFC3	11888
PCNA	11595
RPS27A	11143
UBB	10939
RFC2	10552
RPA2	9854
REV3L	9600
MAD2L2	9403
UBC	7520
RFC1	5243
RPA1	3220
UBA52	-2054
REV1	-10553

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
RFC3	11888
PCNA	11595
RPS27A	11143
UBB	10939
RFC2	10552
RPA2	9854
REV3L	9600
MAD2L2	9403
UBC	7520
RFC1	5243
RPA1	3220
UBA52	-2054
REV1	-10553

---

Translesion synthesis by POLK

Translesion synthesis by POLK

	1396
set	Translesion synthesis by POLK
setSize	17
pANOVA	5.71e-06
s.dist	0.635
p.adjustANOVA	4.07e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
RFC3	11888
PCNA	11595
RPS27A	11143
UBB	10939
RFC2	10552
RPA2	9854
REV3L	9600
MAD2L2	9403
UBC	7520
POLK	6857
RFC1	5243
RPA1	3220
UBA52	-2054
REV1	-10553

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
RFC3	11888
PCNA	11595
RPS27A	11143
UBB	10939
RFC2	10552
RPA2	9854
REV3L	9600
MAD2L2	9403
UBC	7520
POLK	6857
RFC1	5243
RPA1	3220
UBA52	-2054
REV1	-10553

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	422
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.000553
s.dist	0.631
p.adjustANOVA	0.00245

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCT3	10735
CCT6A	10398
CCT4	10231
CCT7	9978
ACTB	9571
CCT8	9247
CCT2	9045
TCP1	8988
CCT5	4037
CCT6B	-5139

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCT3	10735
CCT6A	10398
CCT4	10231
CCT7	9978
ACTB	9571
CCT8	9247
CCT2	9045
TCP1	8988
CCT5	4037
CCT6B	-5139

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	1118
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	60
pANOVA	4e-17
s.dist	0.627
p.adjustANOVA	2.2e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
CDKN1A	12076
PSME3	11980
CKS1B	11954
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP2	11715
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
CCND1	11428
CDK2	11366
RPS27A	11143
PSMB5	11025

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
CDKN1A	12076
PSME3	11980
CKS1B	11954
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP2	11715
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
CCND1	11428
CDK2	11366
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
CDKN1B	9662
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
CDK4	9010
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
CCNA2	7816
UBC	7520
PSMC2	7229
PSMD9	7167
CCNA1	6154
CCNE1	5969
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
CCNE2	2492
PSMD6	140
PSME1	-1500
UBA52	-2054
PSMD5	-8988
PSMB8	-9809
PTK6	-10078
PSMB9	-11036

---

The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint

	1351
set	The role of GTSE1 in G2/M progression after G2 checkpoint
setSize	58
pANOVA	4.32e-16
s.dist	0.617
p.adjustANOVA	1.9e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSP90AA1	12629
CCNB2	12588
CDK1	12520
PSMA5	12432
CCNB1	12183
PSMA6	12089
CDKN1A	12076
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
MAPRE1	11582
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSP90AA1	12629
CCNB2	12588
CDK1	12520
PSMA5	12432
CCNB1	12183
PSMA6	12089
CDKN1A	12076
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
MAPRE1	11582
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
GTSE1	9678
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
HSP90AB1	9283
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PLK1	8153
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
FKBPL	5080
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
TP53	-9081
PSMB8	-9809
PSMB9	-11036

---

Metabolism of cofactors

Metabolism of cofactors

	686
set	Metabolism of cofactors
setSize	19
pANOVA	3.58e-06
s.dist	0.614
p.adjustANOVA	2.65e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DHFR	12674
HSP90AA1	12629
GCHFR	12481
CALM1	12384
COQ5	11277
GCH1	11018
COQ2	10825
SPR	10281
PDSS1	9980
COQ3	8274
PDSS2	8200
PTS	8026
COQ6	6298
PRKG2	5985
IDH1	4854
COQ9	2938
AKT1	-942
NOS3	-1756
COQ7	-3324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DHFR	12674
HSP90AA1	12629
GCHFR	12481
CALM1	12384
COQ5	11277
GCH1	11018
COQ2	10825
SPR	10281
PDSS1	9980
COQ3	8274
PDSS2	8200
PTS	8026
COQ6	6298
PRKG2	5985
IDH1	4854
COQ9	2938
AKT1	-942
NOS3	-1756
COQ7	-3324

---

Regulation of PTEN mRNA translation

Regulation of PTEN mRNA translation

	1050
set	Regulation of PTEN mRNA translation
setSize	12
pANOVA	0.000244
s.dist	-0.612
p.adjustANOVA	0.00117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MOV10	-13419
TNRC6B	-12976
TNRC6A	-12667
PTEN	-12299
AGO2	-12096
PTENP1	-11262
AGO4	-10917
AGO3	-9248
CNOT6L	-9218
AGO1	-9002
TNRC6C	-8274
VAPA	10675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MOV10	-13419
TNRC6B	-12976
TNRC6A	-12667
PTEN	-12299
AGO2	-12096
PTENP1	-11262
AGO4	-10917
AGO3	-9248
CNOT6L	-9218
AGO1	-9002
TNRC6C	-8274
VAPA	10675

---

Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D

	1424
set	Ubiquitin-dependent degradation of Cyclin D
setSize	50
pANOVA	9.5e-14
s.dist	0.608
p.adjustANOVA	2.53e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
CCND1	11428
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
GSK3B	10766
PSMC3	10692
PSMC5	10666

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
CCND1	11428
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
GSK3B	10766
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
CDK4	9010
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

Lagging Strand Synthesis

Lagging Strand Synthesis

	636
set	Lagging Strand Synthesis
setSize	20
pANOVA	2.88e-06
s.dist	0.604
p.adjustANOVA	2.17e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
FEN1	11996
RFC3	11888
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
RFC2	10552
POLD4	10381
POLD2	10201
RPA2	9854
POLD1	7223
POLA1	5953
RFC1	5243
RPA1	3220
POLD3	-6136
LIG1	-6204
DNA2	-9757

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
FEN1	11996
RFC3	11888
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
RFC2	10552
POLD4	10381
POLD2	10201
RPA2	9854
POLD1	7223
POLA1	5953
RFC1	5243
RPA1	3220
POLD3	-6136
LIG1	-6204
DNA2	-9757

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

	1066
set	Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize	48
pANOVA	7.16e-13
s.dist	0.598
p.adjustANOVA	1.5e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PAK2	9865
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

Removal of the Flap Intermediate

Removal of the Flap Intermediate

	1086
set	Removal of the Flap Intermediate
setSize	14
pANOVA	0.000118
s.dist	0.594
p.adjustANOVA	0.000653

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA3	12466
FEN1	11996
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
POLD4	10381
POLD2	10201
RPA2	9854
POLD1	7223
POLA1	5953
RPA1	3220
POLD3	-6136
DNA2	-9757

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA3	12466
FEN1	11996
POLA2	11680
PCNA	11595
PRIM1	11591
PRIM2	10724
POLD4	10381
POLD2	10201
RPA2	9854
POLD1	7223
POLA1	5953
RPA1	3220
POLD3	-6136
DNA2	-9757

---

Vpu mediated degradation of CD4

Vpu mediated degradation of CD4

	1444
set	Vpu mediated degradation of CD4
setSize	50
pANOVA	3.71e-13
s.dist	0.594
p.adjustANOVA	8.3e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
CD4	6771
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
BTRC	2663
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

	213
set	Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize	11
pANOVA	0.000687
s.dist	-0.591
p.adjustANOVA	0.00297

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MOV10	-13419
TNRC6B	-12976
TNRC6A	-12667
AGO2	-12096
PTENP1	-11262
AGO4	-10917
AGO3	-9248
CNOT6L	-9218
AGO1	-9002
TNRC6C	-8274
VAPA	10675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MOV10	-13419
TNRC6B	-12976
TNRC6A	-12667
AGO2	-12096
PTENP1	-11262
AGO4	-10917
AGO3	-9248
CNOT6L	-9218
AGO1	-9002
TNRC6C	-8274
VAPA	10675

---

Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling

	771
set	Negative regulation of NOTCH4 signaling
setSize	54
pANOVA	6.48e-14
s.dist	0.589
p.adjustANOVA	1.79e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
TACC3	11352
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
TACC3	11352
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
YWHAZ	9834
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
NOTCH4	7925
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
RBX1	-331
AKT1	-942
PSME1	-1500
UBA52	-2054
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036
FBXW7	-11989

---

Hh mutants are degraded by ERAD

Hh mutants are degraded by ERAD

	539
set	Hh mutants are degraded by ERAD
setSize	54
pANOVA	9.03e-14
s.dist	0.586
p.adjustANOVA	2.44e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SHH	12686
PSMA5	12432
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SHH	12686
PSMA5	12432
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
SYVN1	-439
VCP	-871
PSME1	-1500
DERL2	-1891
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1

	1119
set	SCF-beta-TrCP mediated degradation of Emi1
setSize	53
pANOVA	1.66e-13
s.dist	0.585
p.adjustANOVA	4.05e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
CDC20	11684
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
CDC20	11684
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
FBXO5	10008
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
BTRC	2663
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036
FZR1	-11835

---

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

	386
set	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
setSize	53
pANOVA	2.1e-13
s.dist	0.583
p.adjustANOVA	4.96e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
AURKA	12174
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
AURKA	12174
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
FBXL18	9268
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
RBX1	-331
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
FBXL7	-10389
PSMB9	-11036

---

HuR (ELAVL1) binds and stabilizes mRNA

HuR (ELAVL1) binds and stabilizes mRNA

	543
set	HuR (ELAVL1) binds and stabilizes mRNA
setSize	10
pANOVA	0.00156
s.dist	0.578
p.adjustANOVA	0.00611

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GPRC5A	12612
ANP32A	12121
PRKCA	10091
ELAVL1	10078
ENPP2	9957
PRKCD	9846
XPO1	5851
TNFSF13	1143
NUP214	-329
SET	-1487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GPRC5A	12612
ANP32A	12121
PRKCA	10091
ELAVL1	10078
ENPP2	9957
PRKCD	9846
XPO1	5851
TNFSF13	1143
NUP214	-329
SET	-1487

---

Regulation of BACH1 activity

Regulation of BACH1 activity

	1036
set	Regulation of BACH1 activity
setSize	11
pANOVA	0.000975
s.dist	0.574
p.adjustANOVA	0.0041

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CUL1	12341
SKP2	11715
SKP1	11672
RPS27A	11143
BACH1	11022
UBB	10939
UBC	7520
MAFK	4822
RBX1	-331
UBA52	-2054
FBXL17	-2458

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CUL1	12341
SKP2	11715
SKP1	11672
RPS27A	11143
BACH1	11022
UBB	10939
UBC	7520
MAFK	4822
RBX1	-331
UBA52	-2054
FBXL17	-2458

---

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

	1423
set	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize	50
pANOVA	2.48e-12
s.dist	0.572
p.adjustANOVA	4.45e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
CDC25A	10302
PSMA1	10273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
CDC25A	10302
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
CHEK1	6566
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
CHEK2	-10300
PSMB9	-11036

---

p53-Independent DNA Damage Response

p53-Independent DNA Damage Response

	1473
set	p53-Independent DNA Damage Response
setSize	50
pANOVA	2.48e-12
s.dist	0.572
p.adjustANOVA	4.45e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
CDC25A	10302
PSMA1	10273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
CDC25A	10302
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
CHEK1	6566
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
CHEK2	-10300
PSMB9	-11036

---

p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint

	1474
set	p53-Independent G1/S DNA damage checkpoint
setSize	50
pANOVA	2.48e-12
s.dist	0.572
p.adjustANOVA	4.45e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
CDC25A	10302
PSMA1	10273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
CDC25A	10302
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
CHEK1	6566
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
CHEK2	-10300
PSMB9	-11036

---

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

	1294
set	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
setSize	13
pANOVA	0.000363
s.dist	-0.571
p.adjustANOVA	0.00168

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1C3	-14455
HSD3B7	-13620
AKR1C1	-13255
CYP27A1	-12994
RXRA	-12352
AKR1C2	-12236
NCOA1	-9240
NR1H4	-5408
NCOA2	-4776
CYP7B1	-4552
CYP8B1	-3420
PTGIS	-3347
AKR1D1	-3092

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1C3	-14455
HSD3B7	-13620
AKR1C1	-13255
CYP27A1	-12994
RXRA	-12352
AKR1C2	-12236
NCOA1	-9240
NR1H4	-5408
NCOA2	-4776
CYP7B1	-4552
CYP8B1	-3420
PTGIS	-3347
AKR1D1	-3092

---

Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM

	1200
set	Signaling by FGFR2 IIIa TM
setSize	19
pANOVA	1.82e-05
s.dist	0.568
p.adjustANOVA	0.000118

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2L	12317
NCBP2	12178
POLR2K	11614
POLR2C	11159
POLR2G	10585
POLR2H	9951
GTF2F2	9803
FGFR2	9491
POLR2E	8987
POLR2B	8936
NCBP1	8822
FGF1	6074
GTF2F1	6038
POLR2D	3369
POLR2I	2877
POLR2F	2706
POLR2A	921
POLR2J	-1668
FGF2	-3988

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2L	12317
NCBP2	12178
POLR2K	11614
POLR2C	11159
POLR2G	10585
POLR2H	9951
GTF2F2	9803
FGFR2	9491
POLR2E	8987
POLR2B	8936
NCBP1	8822
FGF1	6074
GTF2F1	6038
POLR2D	3369
POLR2I	2877
POLR2F	2706
POLR2A	921
POLR2J	-1668
FGF2	-3988

---

Hedgehog ligand biogenesis

Hedgehog ligand biogenesis

	532
set	Hedgehog ligand biogenesis
setSize	63
pANOVA	7.41e-15
s.dist	0.566
p.adjustANOVA	2.45e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SHH	12686
PSMA5	12432
P4HB	12402
NOTUM	12257
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
PSMB5	11025
PSMD13	10950

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SHH	12686
PSMA5	12432
P4HB	12402
NOTUM	12257
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
ADAM17	10197
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
GPC5	9226
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
DISP2	7403
PSMC2	7229
PSMD9	7167
HHAT	3962
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
DHH	660
PSMD6	140
SYVN1	-439
VCP	-871
PSME1	-1500
DERL2	-1891
IHH	-1989
UBA52	-2054
PSME4	-6905
SCUBE2	-7546
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

	1371
set	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
setSize	16
pANOVA	8.85e-05
s.dist	0.566
p.adjustANOVA	0.000501

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYBL2	12626
CDK1	12520
TFDP2	12250
TFDP1	11600
E2F1	10289
RBBP4	9908
RBL1	9200
LIN52	8996
CCNA2	7816
LIN9	7328
E2F4	7326
LIN54	6601
HDAC1	4759
E2F5	1156
RBL2	-1061
LIN37	-12099

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYBL2	12626
CDK1	12520
TFDP2	12250
TFDP1	11600
E2F1	10289
RBBP4	9908
RBL1	9200
LIN52	8996
CCNA2	7816
LIN9	7328
E2F4	7326
LIN54	6601
HDAC1	4759
E2F5	1156
RBL2	-1061
LIN37	-12099

---

Purine salvage

Purine salvage

	931
set	Purine salvage
setSize	12
pANOVA	0.000696
s.dist	0.565
p.adjustANOVA	0.00299

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APRT	12430
HPRT1	12035
AMPD3	12028
DGUOK	11198
GMPR2	11196
ADK	10805
ADAL	10453
PNP	10254
GMPR	9152
DCK	7645
ADA	-12093
AMPD2	-13284

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APRT	12430
HPRT1	12035
AMPD3	12028
DGUOK	11198
GMPR2	11196
ADK	10805
ADAL	10453
PNP	10254
GMPR	9152
DCK	7645
ADA	-12093
AMPD2	-13284

---

GLI3 is processed to GLI3R by the proteasome

GLI3 is processed to GLI3R by the proteasome

	466
set	GLI3 is processed to GLI3R by the proteasome
setSize	57
pANOVA	1.58e-13
s.dist	0.565
p.adjustANOVA	3.99e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
GSK3B	10766
PSMC3	10692

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
GSK3B	10766
PSMC3	10692
PSMC5	10666
PSMA1	10273
PRKACA	10142
PRKACB	10089
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
BTRC	2663
SUFU	2472
PSMD6	140
RBX1	-331
PSME1	-1500
UBA52	-2054
GLI3	-4826
CSNK1A1	-6034
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G

	1436
set	Vif-mediated degradation of APOBEC3G
setSize	52
pANOVA	1.92e-12
s.dist	0.564
p.adjustANOVA	3.71e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOBEC3G	12721
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
ELOC	10337

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOBEC3G	12721
PSMA5	12432
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
ELOC	10337
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
CUL5	3157
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
RBX1	-331
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036
ELOB	-11356

---

Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC

	438
set	Formation of tubulin folding intermediates by CCT/TriC
setSize	23
pANOVA	2.97e-06
s.dist	0.563
p.adjustANOVA	2.22e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBB4A	12547
TUBA1B	12444
TUBA1C	12233
TUBB4B	12200
TUBB2A	11257
TUBB2B	11043
CCT3	10735
TUBB3	10556
TUBB6	10549
TUBAL3	10512
CCT6A	10398
CCT4	10231
CCT7	9978
TUBA1A	9909
CCT8	9247
CCT2	9045
TCP1	8988
CCT5	4037
TUBB1	634
TUBA3D	-2667

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBB4A	12547
TUBA1B	12444
TUBA1C	12233
TUBB4B	12200
TUBB2A	11257
TUBB2B	11043
CCT3	10735
TUBB3	10556
TUBB6	10549
TUBAL3	10512
CCT6A	10398
CCT4	10231
CCT7	9978
TUBA1A	9909
CCT8	9247
CCT2	9045
TCP1	8988
CCT5	4037
TUBB1	634
TUBA3D	-2667
CCT6B	-5139
TUBA8	-8748
TUBA4A	-14060

---

Hh mutants abrogate ligand secretion

Hh mutants abrogate ligand secretion

	538
set	Hh mutants abrogate ligand secretion
setSize	57
pANOVA	2.06e-13
s.dist	0.562
p.adjustANOVA	4.94e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SHH	12686
PSMA5	12432
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SHH	12686
PSMA5	12432
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
HHAT	3962
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
DHH	660
PSMD6	140
SYVN1	-439
VCP	-871
PSME1	-1500
DERL2	-1891
IHH	-1989
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036

---

Defective CFTR causes cystic fibrosis

Defective CFTR causes cystic fibrosis

	273
set	Defective CFTR causes cystic fibrosis
setSize	58
pANOVA	1.36e-13
s.dist	0.561
p.adjustANOVA	3.48e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
DERL1	11116
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
OS9	12176
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
SEL1L	11387
ERLEC1	11203
RPS27A	11143
DERL1	11116
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
ERLIN1	9281
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
RNF5	7917
UBC	7520
PSMC2	7229
PSMD9	7167
DERL3	5331
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
VCP	-871
PSME1	-1500
DERL2	-1891
UBA52	-2054
RNF185	-3011
PSME4	-6905
PSMD5	-8988
ERLIN2	-9528
PSMB8	-9809
PSMB9	-11036

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

	188
set	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize	13
pANOVA	0.000462
s.dist	0.561
p.adjustANOVA	0.00208

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDK1	12520
YWHAQ	12361
CCNB1	12183
CDC25C	11793
YWHAB	10175
YWHAZ	9834
YWHAG	9039
YWHAH	8974
YWHAE	8402
SFN	8046
CHEK1	6566
CHEK2	-10300
WEE1	-11751

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDK1	12520
YWHAQ	12361
CCNB1	12183
CDC25C	11793
YWHAB	10175
YWHAZ	9834
YWHAG	9039
YWHAH	8974
YWHAE	8402
SFN	8046
CHEK1	6566
CHEK2	-10300
WEE1	-11751

---

Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER

	478
set	Gap-filling DNA repair synthesis and ligation in GG-NER
setSize	25
pANOVA	1.22e-06
s.dist	0.56
p.adjustANOVA	9.83e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
RFC3	11888
POLE2	11628
PCNA	11595
POLE3	11495
RPS27A	11143
UBB	10939
RFC2	10552
POLD4	10381
POLD2	10201
POLE4	10120
RPA2	9854
UBC	7520
POLD1	7223
POLK	6857
RFC1	5243
LIG3	4937
RPA1	3220

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
RFC3	11888
POLE2	11628
PCNA	11595
POLE3	11495
RPS27A	11143
UBB	10939
RFC2	10552
POLD4	10381
POLD2	10201
POLE4	10120
RPA2	9854
UBC	7520
POLD1	7223
POLK	6857
RFC1	5243
LIG3	4937
RPA1	3220
POLE	853
UBA52	-2054
POLD3	-6136
LIG1	-6204
XRCC1	-9471

---

PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair

	825
set	PCNA-Dependent Long Patch Base Excision Repair
setSize	21
pANOVA	8.81e-06
s.dist	0.56
p.adjustANOVA	6.02e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
FEN1	11996
RFC3	11888
POLE2	11628
PCNA	11595
POLE3	11495
RFC2	10552
POLD4	10381
POLD2	10201
POLE4	10120
RPA2	9854
POLD1	7223
RFC1	5243
RPA1	3220
APEX1	2828
POLE	853
POLD3	-6136
LIG1	-6204

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA3	12466
RFC4	12293
RFC5	12157
FEN1	11996
RFC3	11888
POLE2	11628
PCNA	11595
POLE3	11495
RFC2	10552
POLD4	10381
POLD2	10201
POLE4	10120
RPA2	9854
POLD1	7223
RFC1	5243
RPA1	3220
APEX1	2828
POLE	853
POLD3	-6136
LIG1	-6204
POLB	-12017

---

NIK–>noncanonical NF-kB signaling

NIK–>noncanonical NF-kB signaling

	745
set	NIK–>noncanonical NF-kB signaling
setSize	57
pANOVA	2.86e-13
s.dist	0.559
p.adjustANOVA	6.54e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
PSMC3	10692
PSMC5	10666
MAP3K14	10609
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
UBE2M	9270
PSMD7	9260
PSMA7	9241
FBXW11	8658
PSMD4	8653
PSMD1	8598
PSMD14	8452
CHUK	8379
PSMA4	8117
PSMD2	7977
UBA3	7789
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
BTRC	2663
PSMD6	140
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036
NFKB2	-13541
RELB	-13570

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	752
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	11
pANOVA	0.00134
s.dist	0.559
p.adjustANOVA	0.00537

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADAM10	12378
APH1B	11194
APH1A	10641
PSENEN	9981
YWHAZ	9834
NCSTN	8328
NOTCH4	7925
PSEN1	7309
PSEN2	5253
DLL4	5176
JAG1	-14025

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADAM10	12378
APH1B	11194
APH1A	10641
PSENEN	9981
YWHAZ	9834
NCSTN	8328
NOTCH4	7925
PSEN1	7309
PSEN2	5253
DLL4	5176
JAG1	-14025

---

MASTL Facilitates Mitotic Progression

MASTL Facilitates Mitotic Progression

	662
set	MASTL Facilitates Mitotic Progression
setSize	10
pANOVA	0.00225
s.dist	0.558
p.adjustANOVA	0.0084

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ENSA	12558
CDK1	12520
ARPP19	12276
CCNB1	12183
PPP2CA	12020
MASTL	11508
PPP2R1B	6872
PPP2R2D	6439
PPP2R1A	-7177
PPP2CB	-12032

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ENSA	12558
CDK1	12520
ARPP19	12276
CCNB1	12183
PPP2CA	12020
MASTL	11508
PPP2R1B	6872
PPP2R2D	6439
PPP2R1A	-7177
PPP2CB	-12032

---

Orc1 removal from chromatin

Orc1 removal from chromatin

	818
set	Orc1 removal from chromatin
setSize	69
pANOVA	1.12e-15
s.dist	0.557
p.adjustANOVA	4.64e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
MCM2	12140
MCM4	12113
PSMA6	12089
CDT1	12021
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
CDC6	11743
PSMD3	11738
PSMB3	11727
SKP2	11715
SKP1	11672
ORC1	11656
PSMC1	11554
PSMD11	11493
PSMB2	11467
CDK2	11366

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
MCM2	12140
MCM4	12113
PSMA6	12089
CDT1	12021
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
CDC6	11743
PSMD3	11738
PSMB3	11727
SKP2	11715
SKP1	11672
ORC1	11656
PSMC1	11554
PSMD11	11493
PSMB2	11467
CDK2	11366
MCM3	11283
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
MCM5	10865
PSMD10	10775
PSMC3	10692
PSMC5	10666
MCM8	10355
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
MCM6	9193
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
CCNA2	7816
UBC	7520
PSMC2	7229
PSMD9	7167
ORC3	6795
CCNA1	6154
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
ORC4	2326
PSMD6	140
RBX1	-331
PSME1	-1500
UBA52	-2054
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
ORC6	-10133
ORC5	-10855
PSMB9	-11036
ORC2	-12965
MCM7	-13907

---

Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

	1082
set	Regulation of ornithine decarboxylase (ODC)
setSize	49
pANOVA	1.51e-11
s.dist	0.557
p.adjustANOVA	2.37e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
OAZ2	12229
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
NQO1	11204
PSMB5	11025
PSMD13	10950
PSMD10	10775
PSMC3	10692
PSMC5	10666
OAZ1	10369
PSMA1	10273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
OAZ2	12229
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
PSMC1	11554
PSMD11	11493
PSMB2	11467
NQO1	11204
PSMB5	11025
PSMD13	10950
PSMD10	10775
PSMC3	10692
PSMC5	10666
OAZ1	10369
PSMA1	10273
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
PSMC2	7229
PSMD9	7167
AZIN1	3170
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
PSMD6	140
PSME1	-1500
PSME4	-6905
OAZ3	-7199
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036
ODC1	-12824

---

Degradation of GLI2 by the proteasome

Degradation of GLI2 by the proteasome

	292
set	Degradation of GLI2 by the proteasome
setSize	57
pANOVA	3.74e-13
s.dist	0.556
p.adjustANOVA	8.3e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
GSK3B	10766
PSMC3	10692

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	12432
CUL1	12341
PSMA6	12089
PSME3	11980
PSMD12	11895
PSMA3	11818
PSMA2	11784
PSMD3	11738
PSMB3	11727
SKP1	11672
PSMC1	11554
PSMD11	11493
PSMB2	11467
RPS27A	11143
PSMB5	11025
PSMD13	10950
UBB	10939
PSMD10	10775
GSK3B	10766
PSMC3	10692
PSMC5	10666
PSMA1	10273
PRKACA	10142
PRKACB	10089
PSMB6	9989
PSMC6	9977
PSMF1	9900
PSMB4	9649
PSMB1	9583
PSMC4	9483
PSMD8	9468
PSMD7	9260
PSMA7	9241
PSMD4	8653
PSMD1	8598
PSMD14	8452
PSMA4	8117
PSMD2	7977
UBC	7520
PSMC2	7229
PSMD9	7167
PSME2	3149
SEM1	3082
PSMB7	2916
PSMB10	2792
BTRC	2663
SUFU	2472
PSMD6	140
RBX1	-331
PSME1	-1500
UBA52	-2054
CSNK1A1	-6034
PSME4	-6905
PSMD5	-8988
PSMB8	-9809
PSMB9	-11036
GLI2	-11655

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.2.2              echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.1               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58                 fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [23] IRanges_2.30.0              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.9                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.7                ggplot2_3.3.6              
## [35] tidyverse_1.3.1             zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.7             polylabelr_0.2.0      
##   [7] splines_4.2.1          BiocParallel_1.30.3    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.3            magrittr_2.0.3        
##  [13] memoise_2.0.1          tzdb_0.3.0             Biostrings_2.64.0     
##  [16] annotate_1.74.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.3             rvest_1.0.2           
##  [22] haven_2.5.0            xfun_0.31              crayon_1.5.1          
##  [25] RCurl_1.98-1.7         jsonlite_1.8.0         genefilter_1.78.0     
##  [28] survival_3.4-0         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.42.0        XVector_0.36.0        
##  [34] webshot_0.5.3          DelayedArray_0.22.0    scales_1.2.0          
##  [37] DBI_1.1.3              Rcpp_1.0.8.3           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.3             RColorBrewer_1.1-3     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.9          XML_3.99-0.10         
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       rlang_1.0.3           
##  [55] later_1.3.0            AnnotationDbi_1.58.0   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.1            cachem_1.0.6          
##  [61] cli_3.3.0              generics_0.1.2         RSQLite_2.2.14        
##  [64] broom_0.8.0            evaluate_0.15          fastmap_1.1.0         
##  [67] yaml_2.3.5             knitr_1.39             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.36.2       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.1        
##  [76] rstudioapi_0.13        png_0.1-7              reprex_2.0.1          
##  [79] geneplotter_1.74.0     bslib_0.3.1            stringi_1.7.6         
##  [82] highr_0.9              lattice_0.20-45        Matrix_1.4-1          
##  [85] vctrs_0.4.1            pillar_1.7.0           lifecycle_1.0.1       
##  [88] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [91] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [94] KernSmooth_2.23-20     gridExtra_2.3          codetools_0.2-18      
##  [97] assertthat_0.2.1       withr_2.5.0            GenomeInfoDbData_1.2.8
## [100] parallel_4.2.1         hms_1.1.1              grid_4.2.1            
## [103] rmarkdown_2.14         shiny_1.7.1            lubridate_1.8.0

END of report