Mitch Report

date generated: 2022-08-23

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     x
## 5_8S_rRNA  13.3741078
## 7SK         8.2273400
## A1BG        6.5685508
## A1BG-AS1    2.0363758
## A1CF       -0.3352928
## A2M       -19.6839168

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2512
num_genes_in_profile	26163
duplicated_genes_present	0
num_profile_genes_in_sets	8997
num_profile_genes_not_in_sets	17166

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2512
num_genesets_excluded	1033
num_genesets_included	1479

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 52 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
CLEC7A (Dectin-1) induces NFAT activation	11	9.68e-07	-0.853	6.07e-06
Cohesin Loading onto Chromatin	10	3.04e-06	-0.852	1.63e-05
Laminin interactions	23	4.40e-11	-0.793	5.87e-10
S33 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783	1.16e-06
S37 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783	1.16e-06
S45 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783	1.16e-06
Signaling by CTNNB1 phospho-site mutants	15	1.53e-07	-0.783	1.16e-06
Signaling by GSK3beta mutants	15	1.53e-07	-0.783	1.16e-06
T41 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783	1.16e-06
Signaling by Hippo	20	1.64e-09	-0.779	1.78e-08
Syndecan interactions	20	1.76e-09	-0.777	1.88e-08
MET activates RAP1 and RAC1	11	8.89e-06	-0.773	4.31e-05
APC truncation mutants have impaired AXIN binding	14	6.48e-07	-0.768	4.24e-06
AXIN missense mutants destabilize the destruction complex	14	6.48e-07	-0.768	4.24e-06
Signaling by AMER1 mutants	14	6.48e-07	-0.768	4.24e-06
Signaling by APC mutants	14	6.48e-07	-0.768	4.24e-06
Signaling by AXIN mutants	14	6.48e-07	-0.768	4.24e-06
Truncations of AMER1 destabilize the destruction complex	14	6.48e-07	-0.768	4.24e-06
ERKs are inactivated	13	1.68e-06	-0.767	9.67e-06
MET activates PTK2 signaling	18	2.19e-08	-0.762	2.01e-07
Establishment of Sister Chromatid Cohesion	11	1.50e-05	-0.754	6.74e-05
MET promotes cell motility	29	5.60e-12	-0.739	8.81e-11
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	4.77e-06	-0.733	2.44e-05
Defective EXT2 causes exostoses 2	13	4.77e-06	-0.733	2.44e-05
tRNA processing in the mitochondrion	20	1.43e-08	0.732	1.35e-07
Synthesis of PIPs at the early endosome membrane	16	4.19e-07	-0.730	2.92e-06
Complex I biogenesis	57	1.31e-21	0.730	5.88e-20
Beta-catenin phosphorylation cascade	17	1.86e-07	-0.730	1.37e-06
Signaling by PDGFRA extracellular domain mutants	12	1.41e-05	-0.724	6.37e-05
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	1.41e-05	-0.724	6.37e-05
Non-integrin membrane-ECM interactions	42	8.66e-16	-0.717	2.00e-14
Viral mRNA Translation	87	6.88e-31	0.716	8.48e-29
Peptide chain elongation	87	7.93e-31	0.715	9.02e-29
Signaling by PDGFR in disease	19	8.03e-08	-0.711	6.49e-07
DCC mediated attractive signaling	14	4.24e-06	-0.710	2.22e-05
Activation of RAC1	13	9.42e-06	-0.709	4.53e-05
FOXO-mediated transcription of cell cycle genes	15	2.13e-06	-0.707	1.19e-05
HDMs demethylate histones	22	1.56e-08	-0.696	1.46e-07
Adenylate cyclase inhibitory pathway	12	3.89e-05	-0.686	1.58e-04
Eukaryotic Translation Termination	91	1.29e-29	0.684	1.27e-27
Synthesis of PIPs at the late endosome membrane	11	8.49e-05	-0.684	3.19e-04
ERK/MAPK targets	22	2.97e-08	-0.682	2.66e-07
Selenocysteine synthesis	91	3.21e-29	0.680	2.97e-27
Eukaryotic Translation Elongation	92	5.39e-29	0.673	4.43e-27
Platelet sensitization by LDL	15	6.79e-06	-0.671	3.36e-05
rRNA processing in the mitochondrion	24	1.27e-08	0.671	1.21e-07
Signaling by FLT3 fusion proteins	19	4.21e-07	-0.670	2.92e-06
Signaling by FGFR3 fusions in cancer	10	2.58e-04	-0.667	8.89e-04
Defective B4GALT7 causes EDS, progeroid type	18	1.16e-06	-0.662	7.07e-06
ALK mutants bind TKIs	12	7.86e-05	-0.658	2.99e-04
Interleukin-6 signaling	11	1.74e-04	-0.654	6.20e-04
Cell-extracellular matrix interactions	16	6.27e-06	-0.652	3.11e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
CLEC7A (Dectin-1) induces NFAT activation	11	9.68e-07	-0.853000	6.07e-06
Cohesin Loading onto Chromatin	10	3.04e-06	-0.852000	1.63e-05
Laminin interactions	23	4.40e-11	-0.793000	5.87e-10
S33 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783000	1.16e-06
S37 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783000	1.16e-06
S45 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783000	1.16e-06
Signaling by CTNNB1 phospho-site mutants	15	1.53e-07	-0.783000	1.16e-06
Signaling by GSK3beta mutants	15	1.53e-07	-0.783000	1.16e-06
T41 mutants of beta-catenin aren’t phosphorylated	15	1.53e-07	-0.783000	1.16e-06
Signaling by Hippo	20	1.64e-09	-0.779000	1.78e-08
Syndecan interactions	20	1.76e-09	-0.777000	1.88e-08
MET activates RAP1 and RAC1	11	8.89e-06	-0.773000	4.31e-05
APC truncation mutants have impaired AXIN binding	14	6.48e-07	-0.768000	4.24e-06
AXIN missense mutants destabilize the destruction complex	14	6.48e-07	-0.768000	4.24e-06
Signaling by AMER1 mutants	14	6.48e-07	-0.768000	4.24e-06
Signaling by APC mutants	14	6.48e-07	-0.768000	4.24e-06
Signaling by AXIN mutants	14	6.48e-07	-0.768000	4.24e-06
Truncations of AMER1 destabilize the destruction complex	14	6.48e-07	-0.768000	4.24e-06
ERKs are inactivated	13	1.68e-06	-0.767000	9.67e-06
MET activates PTK2 signaling	18	2.19e-08	-0.762000	2.01e-07
Establishment of Sister Chromatid Cohesion	11	1.50e-05	-0.754000	6.74e-05
MET promotes cell motility	29	5.60e-12	-0.739000	8.81e-11
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	4.77e-06	-0.733000	2.44e-05
Defective EXT2 causes exostoses 2	13	4.77e-06	-0.733000	2.44e-05
tRNA processing in the mitochondrion	20	1.43e-08	0.732000	1.35e-07
Synthesis of PIPs at the early endosome membrane	16	4.19e-07	-0.730000	2.92e-06
Complex I biogenesis	57	1.31e-21	0.730000	5.88e-20
Beta-catenin phosphorylation cascade	17	1.86e-07	-0.730000	1.37e-06
Signaling by PDGFRA extracellular domain mutants	12	1.41e-05	-0.724000	6.37e-05
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	1.41e-05	-0.724000	6.37e-05
Non-integrin membrane-ECM interactions	42	8.66e-16	-0.717000	2.00e-14
Viral mRNA Translation	87	6.88e-31	0.716000	8.48e-29
Peptide chain elongation	87	7.93e-31	0.715000	9.02e-29
Signaling by PDGFR in disease	19	8.03e-08	-0.711000	6.49e-07
DCC mediated attractive signaling	14	4.24e-06	-0.710000	2.22e-05
Activation of RAC1	13	9.42e-06	-0.709000	4.53e-05
FOXO-mediated transcription of cell cycle genes	15	2.13e-06	-0.707000	1.19e-05
HDMs demethylate histones	22	1.56e-08	-0.696000	1.46e-07
Adenylate cyclase inhibitory pathway	12	3.89e-05	-0.686000	1.58e-04
Eukaryotic Translation Termination	91	1.29e-29	0.684000	1.27e-27
Synthesis of PIPs at the late endosome membrane	11	8.49e-05	-0.684000	3.19e-04
ERK/MAPK targets	22	2.97e-08	-0.682000	2.66e-07
Selenocysteine synthesis	91	3.21e-29	0.680000	2.97e-27
Eukaryotic Translation Elongation	92	5.39e-29	0.673000	4.43e-27
Platelet sensitization by LDL	15	6.79e-06	-0.671000	3.36e-05
rRNA processing in the mitochondrion	24	1.27e-08	0.671000	1.21e-07
Signaling by FLT3 fusion proteins	19	4.21e-07	-0.670000	2.92e-06
Signaling by FGFR3 fusions in cancer	10	2.58e-04	-0.667000	8.89e-04
Defective B4GALT7 causes EDS, progeroid type	18	1.16e-06	-0.662000	7.07e-06
ALK mutants bind TKIs	12	7.86e-05	-0.658000	2.99e-04
Interleukin-6 signaling	11	1.74e-04	-0.654000	6.20e-04
Cell-extracellular matrix interactions	16	6.27e-06	-0.652000	3.11e-05
RORA activates gene expression	18	1.70e-06	-0.651000	9.74e-06
Formation of a pool of free 40S subunits	99	3.75e-29	0.651000	3.26e-27
PKA-mediated phosphorylation of CREB	18	1.74e-06	-0.651000	9.94e-06
YAP1- and WWTR1 (TAZ)-stimulated gene expression	12	1.02e-04	-0.648000	3.79e-04
Caspase activation via Dependence Receptors in the absence of ligand	10	4.06e-04	-0.646000	1.34e-03
PKA activation	16	7.79e-06	-0.645000	3.82e-05
Synthesis of PIPs at the Golgi membrane	15	1.95e-05	-0.637000	8.56e-05
Regulation of gene expression by Hypoxia-inducible Factor	11	2.82e-04	-0.632000	9.58e-04
Role of LAT2/NTAL/LAB on calcium mobilization	13	8.04e-05	-0.632000	3.05e-04
Regulation of signaling by CBL	18	3.88e-06	-0.629000	2.06e-05
RHOV GTPase cycle	37	3.62e-11	-0.628000	4.92e-10
Interleukin-15 signaling	14	5.26e-05	-0.624000	2.08e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	6.34e-27	0.624000	4.26e-25
Formation of ATP by chemiosmotic coupling	18	4.70e-06	0.623000	2.42e-05
Downstream signal transduction	29	7.03e-09	-0.621000	6.93e-08
VEGFR2 mediated cell proliferation	19	2.97e-06	-0.619000	1.60e-05
RHOU GTPase cycle	40	1.43e-11	-0.617000	2.16e-10
Gastrin-CREB signalling pathway via PKC and MAPK	17	1.07e-05	-0.617000	5.02e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	7.64e-25	0.617000	4.71e-23
CTLA4 inhibitory signaling	18	6.23e-06	-0.615000	3.10e-05
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	7.61e-04	-0.615000	2.31e-03
Signaling by KIT in disease	20	1.97e-06	-0.614000	1.10e-05
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.97e-06	-0.614000	1.10e-05
Prolonged ERK activation events	14	6.92e-05	-0.614000	2.65e-04
Nephrin family interactions	20	2.46e-06	-0.608000	1.35e-05
Other semaphorin interactions	15	4.86e-05	-0.606000	1.93e-04
RHOF GTPase cycle	41	2.03e-11	-0.605000	2.94e-10
STAT5 activation downstream of FLT3 ITD mutants	10	9.72e-04	-0.602000	2.89e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	125	3.41e-31	0.601000	5.04e-29
Signal transduction by L1	21	2.24e-06	-0.596000	1.23e-05
Defective B3GAT3 causes JDSSDHD	18	1.24e-05	-0.595000	5.64e-05
Miscellaneous transport and binding events	24	5.25e-07	-0.591000	3.57e-06
Signaling by FLT3 ITD and TKD mutants	16	4.68e-05	-0.588000	1.86e-04
Signaling by Leptin	10	1.29e-03	-0.588000	3.62e-03
Respiratory electron transport	103	6.97e-25	0.587000	4.48e-23
Ephrin signaling	19	9.77e-06	-0.586000	4.63e-05
RHOJ GTPase cycle	54	9.18e-14	-0.586000	1.81e-12
MECP2 regulates neuronal receptors and channels	17	2.93e-05	-0.585000	1.23e-04
Defective B3GALT6 causes EDSP2 and SEMDJL1	18	1.71e-05	-0.585000	7.58e-05
Frs2-mediated activation	12	4.55e-04	-0.584000	1.48e-03
HS-GAG biosynthesis	27	1.71e-07	-0.581000	1.26e-06
EGR2 and SOX10-mediated initiation of Schwann cell myelination	25	5.03e-07	-0.580000	3.46e-06
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	5.35e-04	-0.577000	1.71e-03
RAF-independent MAPK1/3 activation	22	2.81e-06	-0.577000	1.52e-05
Insulin processing	25	6.05e-07	-0.576000	4.07e-06
Signal regulatory protein family interactions	11	9.87e-04	-0.574000	2.93e-03
Regulation of PTEN mRNA translation	12	5.99e-04	-0.572000	1.88e-03
RHO GTPases activate KTN1	11	1.02e-03	-0.572000	2.98e-03
RHOH GTPase cycle	36	3.18e-09	-0.570000	3.33e-08
RHO GTPases Activate WASPs and WAVEs	36	3.45e-09	-0.569000	3.55e-08
Netrin-1 signaling	45	4.65e-11	-0.567000	6.14e-10
RHOQ GTPase cycle	58	9.01e-14	-0.565000	1.80e-12
Mitotic Telophase/Cytokinesis	13	4.35e-04	-0.563000	1.42e-03
Regulation of RUNX1 Expression and Activity	18	3.60e-05	-0.562000	1.48e-04
MAPK targets/ Nuclear events mediated by MAP kinases	31	6.92e-08	-0.559000	5.81e-07
Signaling by WNT in cancer	33	2.94e-08	-0.557000	2.66e-07
Regulation of localization of FOXO transcription factors	12	8.36e-04	-0.557000	2.50e-03
Heme signaling	43	2.62e-10	-0.557000	3.07e-09
Growth hormone receptor signaling	20	1.63e-05	-0.557000	7.30e-05
RAC2 GTPase cycle	86	5.35e-19	-0.555000	1.61e-17
Regulation of commissural axon pathfinding by SLIT and ROBO	10	2.45e-03	-0.553000	6.38e-03
RAC3 GTPase cycle	90	1.13e-19	-0.553000	3.72e-18
Recycling pathway of L1	27	6.63e-07	-0.553000	4.28e-06
RHOC GTPase cycle	72	4.88e-16	-0.553000	1.16e-14
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	1.51e-03	-0.552000	4.17e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	1.79e-11	-0.549000	2.63e-10
Mitochondrial translation elongation	90	2.79e-19	0.547000	8.77e-18
Apoptotic cleavage of cellular proteins	34	3.90e-08	-0.544000	3.43e-07
STAT3 nuclear events downstream of ALK signaling	10	2.88e-03	-0.544000	7.34e-03
RUNX3 regulates NOTCH signaling	14	4.24e-04	-0.544000	1.39e-03
Mitochondrial translation initiation	90	4.60e-19	0.543000	1.42e-17
FCGR3A-mediated phagocytosis	56	1.99e-12	-0.543000	3.43e-11
Leishmania phagocytosis	56	1.99e-12	-0.543000	3.43e-11
Parasite infection	56	1.99e-12	-0.543000	3.43e-11
Deadenylation of mRNA	22	1.09e-05	-0.542000	5.07e-05
Mitochondrial translation termination	90	2.10e-18	0.533000	6.09e-17
Signaling by cytosolic FGFR1 fusion mutants	18	9.28e-05	-0.532000	3.48e-04
Uptake and function of anthrax toxins	11	2.25e-03	-0.532000	5.93e-03
G-protein mediated events	48	1.87e-10	-0.531000	2.25e-09
SRP-dependent cotranslational protein targeting to membrane	110	5.68e-22	0.531000	2.71e-20
MET receptor recycling	10	3.64e-03	-0.531000	9.11e-03
Formation of the ternary complex, and subsequently, the 43S complex	50	8.27e-11	0.531000	1.05e-09
RHOG GTPase cycle	74	2.98e-15	-0.530000	6.56e-14
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	1.20e-06	-0.530000	7.29e-06
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	5.30e-07	-0.529000	3.60e-06
GTP hydrolysis and joining of the 60S ribosomal subunit	110	1.00e-21	0.528000	4.62e-20
RND1 GTPase cycle	42	3.35e-09	-0.527000	3.49e-08
FCGR3A-mediated IL10 synthesis	32	2.49e-07	-0.527000	1.78e-06
L13a-mediated translational silencing of Ceruloplasmin expression	109	3.49e-21	0.523000	1.26e-19
BMAL1:CLOCK,NPAS2 activates circadian gene expression	26	4.00e-06	-0.522000	2.11e-05
DAG and IP3 signaling	37	3.87e-08	-0.522000	3.43e-07
Ca-dependent events	33	2.09e-07	-0.522000	1.52e-06
Synthesis of PIPs at the plasma membrane	50	1.68e-10	-0.522000	2.03e-09
Signaling by ALK fusions and activated point mutants	55	2.20e-11	-0.521000	3.10e-10
Signaling by ALK in cancer	55	2.20e-11	-0.521000	3.10e-10
CD209 (DC-SIGN) signaling	20	5.67e-05	-0.520000	2.22e-04
PLC beta mediated events	44	2.46e-09	-0.519000	2.62e-08
FCERI mediated Ca+2 mobilization	28	2.08e-06	-0.518000	1.16e-05
PKA activation in glucagon signalling	15	5.35e-04	-0.516000	1.71e-03
Reduction of cytosolic Ca++ levels	12	2.03e-03	-0.514000	5.44e-03
Selenoamino acid metabolism	115	1.53e-21	0.514000	6.66e-20
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	4.23e-11	-0.514000	5.68e-10
VEGFA-VEGFR2 Pathway	92	1.61e-17	-0.513000	4.19e-16
Mitochondrial translation	96	3.34e-18	0.513000	9.32e-17
Circadian Clock	67	4.34e-13	-0.511000	8.13e-12
Activated NTRK2 signals through FRS2 and FRS3	11	3.49e-03	-0.508000	8.79e-03
Aflatoxin activation and detoxification	15	6.75e-04	0.507000	2.08e-03
Constitutive Signaling by Overexpressed ERBB2	11	3.61e-03	-0.507000	9.04e-03
Cap-dependent Translation Initiation	117	2.75e-21	0.506000	1.04e-19
Eukaryotic Translation Initiation	117	2.75e-21	0.506000	1.04e-19
Signaling by VEGF	101	1.64e-18	-0.505000	4.86e-17
Signaling by FGFR4 in disease	11	3.77e-03	-0.504000	9.39e-03
Interleukin-27 signaling	10	5.81e-03	-0.504000	1.35e-02
RHOB GTPase cycle	69	4.94e-13	-0.503000	9.13e-12
MET activates RAS signaling	11	3.94e-03	-0.502000	9.77e-03
Cargo concentration in the ER	31	1.38e-06	-0.501000	8.29e-06
RHOD GTPase cycle	52	4.36e-10	-0.500000	4.94e-09
Signaling by BMP	23	3.61e-05	-0.498000	1.48e-04
Diseases associated with glycosaminoglycan metabolism	35	3.53e-07	-0.497000	2.48e-06
Signaling by Erythropoietin	25	1.69e-05	-0.497000	7.49e-05
CaM pathway	31	1.66e-06	-0.497000	9.61e-06
Calmodulin induced events	31	1.66e-06	-0.497000	9.61e-06
Signaling by MET	66	3.00e-12	-0.496000	5.04e-11
RAF activation	33	8.43e-07	-0.495000	5.35e-06
Signaling by SCF-KIT	42	2.78e-08	-0.495000	2.52e-07
Regulated proteolysis of p75NTR	11	4.52e-03	-0.494000	1.09e-02
Tie2 Signaling	17	4.23e-04	-0.494000	1.39e-03
VEGFR2 mediated vascular permeability	27	9.78e-06	-0.492000	4.63e-05
PI Metabolism	77	8.57e-14	-0.491000	1.74e-12
RND3 GTPase cycle	41	5.54e-08	-0.490000	4.74e-07
Regulation of FOXO transcriptional activity by acetylation	10	7.44e-03	-0.489000	1.69e-02
Sema3A PAK dependent Axon repulsion	16	7.40e-04	-0.487000	2.26e-03
Caspase-mediated cleavage of cytoskeletal proteins	12	3.52e-03	-0.487000	8.83e-03
Zinc transporters	15	1.13e-03	-0.486000	3.24e-03
Response to metal ions	10	7.88e-03	0.485000	1.76e-02
A tetrasaccharide linker sequence is required for GAG synthesis	24	3.92e-05	-0.485000	1.59e-04
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	2.79e-05	-0.484000	1.18e-04
MAPK3 (ERK1) activation	10	8.13e-03	-0.483000	1.81e-02
Erythropoietin activates RAS	14	1.81e-03	-0.482000	4.87e-03
L1CAM interactions	93	1.10e-15	-0.480000	2.51e-14
APC/C:Cdc20 mediated degradation of Cyclin B	24	4.78e-05	0.479000	1.90e-04
COPI-independent Golgi-to-ER retrograde traffic	33	1.89e-06	-0.479000	1.06e-05
Interleukin-3, Interleukin-5 and GM-CSF signaling	38	3.30e-07	-0.478000	2.34e-06
PECAM1 interactions	12	4.20e-03	-0.477000	1.03e-02
The activation of arylsulfatases	10	9.05e-03	-0.477000	1.98e-02
Regulation of actin dynamics for phagocytic cup formation	58	3.36e-10	-0.477000	3.91e-09
Keratan sulfate biosynthesis	24	5.58e-05	-0.475000	2.19e-04
COPI-mediated anterograde transport	79	2.88e-13	-0.475000	5.47e-12
Fcgamma receptor (FCGR) dependent phagocytosis	82	1.10e-13	-0.474000	2.15e-12
RAC1 GTPase cycle	177	1.18e-27	-0.474000	9.15e-26
Unwinding of DNA	12	4.50e-03	0.474000	1.08e-02
Signaling by PDGF	52	3.62e-09	-0.473000	3.70e-08
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	11	6.66e-03	-0.472000	1.53e-02
Interleukin receptor SHC signaling	21	1.84e-04	-0.471000	6.52e-04
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	2.45e-03	-0.468000	6.38e-03
Activation of gene expression by SREBF (SREBP)	42	1.58e-07	-0.467000	1.19e-06
RUNX2 regulates osteoblast differentiation	23	1.06e-04	-0.467000	3.94e-04
Cristae formation	31	6.98e-06	0.466000	3.44e-05
Molecules associated with elastic fibres	26	3.85e-05	-0.466000	1.57e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	1.05e-06	-0.464000	6.48e-06
RHO GTPases activate IQGAPs	11	7.75e-03	-0.464000	1.74e-02
VxPx cargo-targeting to cilium	19	4.77e-04	-0.463000	1.54e-03
CDC42 GTPase cycle	153	5.00e-23	-0.462000	2.64e-21
Elastic fibre formation	36	1.58e-06	-0.462000	9.33e-06
Regulation of KIT signaling	16	1.39e-03	-0.462000	3.87e-03
Signaling by NTRK3 (TRKC)	16	1.42e-03	-0.461000	3.94e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.83e-17	0.460000	6.98e-16
Nonsense-Mediated Decay (NMD)	113	2.83e-17	0.460000	6.98e-16
Signaling by ALK	26	5.03e-05	-0.459000	1.99e-04
Mitochondrial iron-sulfur cluster biogenesis	13	4.21e-03	0.458000	1.03e-02
NOTCH2 intracellular domain regulates transcription	11	8.66e-03	-0.457000	1.91e-02
HS-GAG degradation	19	5.71e-04	-0.456000	1.80e-03
Interleukin-7 signaling	23	1.52e-04	-0.456000	5.50e-04
GAB1 signalosome	17	1.15e-03	-0.455000	3.28e-03
CD28 co-stimulation	30	1.61e-05	-0.455000	7.23e-05
Oncogenic MAPK signaling	77	5.03e-12	-0.455000	8.09e-11
RHOA GTPase cycle	146	3.46e-21	-0.452000	1.26e-19
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	24	1.30e-04	-0.451000	4.74e-04
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	17	1.31e-03	-0.450000	3.67e-03
Keratan sulfate/keratin metabolism	29	2.70e-05	-0.450000	1.16e-04
RET signaling	37	2.18e-06	-0.450000	1.21e-05
NOTCH3 Intracellular Domain Regulates Transcription	22	2.60e-04	-0.450000	8.94e-04
Myogenesis	25	1.11e-04	-0.446000	4.09e-04
Extra-nuclear estrogen signaling	68	1.93e-10	-0.446000	2.31e-09
Integrin signaling	26	8.32e-05	-0.446000	3.13e-04
Activation of BAD and translocation to mitochondria	15	2.82e-03	-0.445000	7.24e-03
Chondroitin sulfate biosynthesis	19	7.97e-04	-0.444000	2.39e-03
Dermatan sulfate biosynthesis	10	1.50e-02	-0.444000	3.12e-02
Post NMDA receptor activation events	56	8.91e-09	-0.444000	8.67e-08
N-Glycan antennae elongation	14	4.09e-03	-0.443000	1.01e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	14	4.11e-03	-0.443000	1.01e-02
Platelet calcium homeostasis	25	1.34e-04	-0.441000	4.85e-04
VLDLR internalisation and degradation	11	1.13e-02	-0.441000	2.41e-02
Regulation of expression of SLITs and ROBOs	166	1.06e-22	0.440000	5.42e-21
Downregulation of SMAD2/3:SMAD4 transcriptional activity	28	5.54e-05	-0.440000	2.18e-04
Retrograde transport at the Trans-Golgi-Network	49	1.01e-07	-0.440000	8.05e-07
Cell-Cell communication	108	3.01e-15	-0.439000	6.56e-14
Notch-HLH transcription pathway	28	5.99e-05	-0.438000	2.34e-04
ER to Golgi Anterograde Transport	131	5.69e-18	-0.437000	1.56e-16
Metal ion SLC transporters	23	3.06e-04	-0.435000	1.03e-03
Transport to the Golgi and subsequent modification	161	2.05e-21	-0.433000	8.53e-20
RUNX2 regulates bone development	30	4.03e-05	-0.433000	1.63e-04
Intra-Golgi and retrograde Golgi-to-ER traffic	179	1.67e-23	-0.432000	9.14e-22
DARPP-32 events	23	3.40e-04	-0.431000	1.14e-03
MAP kinase activation	62	4.35e-09	-0.431000	4.38e-08
Signaling by ERBB2 ECD mutants	16	2.88e-03	-0.430000	7.34e-03
rRNA processing	214	1.94e-27	0.430000	1.37e-25
Constitutive Signaling by EGFRvIII	15	4.03e-03	-0.429000	9.96e-03
Signaling by EGFRvIII in Cancer	15	4.03e-03	-0.429000	9.96e-03
Signalling to ERKs	33	2.12e-05	-0.428000	9.26e-05
Intra-Golgi traffic	43	1.25e-06	-0.427000	7.52e-06
Activation of NMDA receptors and postsynaptic events	69	8.31e-10	-0.427000	9.18e-09
Glutathione conjugation	29	6.85e-05	0.427000	2.62e-04
Signaling by Activin	15	4.19e-03	-0.427000	1.03e-02
RHO GTPase cycle	435	8.83e-53	-0.426000	3.27e-50
RND2 GTPase cycle	41	2.53e-06	-0.425000	1.38e-05
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	1.83e-04	-0.424000	6.52e-04
Golgi Cisternae Pericentriolar Stack Reorganization	14	6.06e-03	-0.424000	1.40e-02
Opioid Signalling	78	9.71e-11	-0.424000	1.22e-09
Ca2+ pathway	56	4.24e-08	-0.423000	3.69e-07
Interleukin-2 signaling	10	2.11e-02	-0.421000	4.17e-02
Golgi Associated Vesicle Biogenesis	55	7.07e-08	-0.420000	5.90e-07
Gap junction degradation	10	2.20e-02	-0.418000	4.33e-02
GPVI-mediated activation cascade	31	6.12e-05	-0.416000	2.37e-04
Signaling by EGFR	50	3.71e-07	-0.415000	2.60e-06
Gap junction trafficking and regulation	21	1.00e-03	-0.415000	2.94e-03
Heparan sulfate/heparin (HS-GAG) metabolism	48	6.81e-07	-0.414000	4.38e-06
EPHB-mediated forward signaling	34	2.93e-05	-0.414000	1.23e-04
Interleukin-35 Signalling	12	1.30e-02	-0.414000	2.73e-02
Regulation of MECP2 expression and activity	29	1.15e-04	-0.414000	4.22e-04
p130Cas linkage to MAPK signaling for integrins	14	7.66e-03	-0.412000	1.73e-02
Signaling by NODAL	19	1.89e-03	-0.412000	5.10e-03
Glycosaminoglycan metabolism	109	1.16e-13	-0.411000	2.23e-12
Major pathway of rRNA processing in the nucleolus and cytosol	180	2.08e-21	0.410000	8.53e-20
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	1.05e-02	-0.410000	2.26e-02
Glutamate and glutamine metabolism	13	1.05e-02	-0.410000	2.26e-02
Sodium/Calcium exchangers	10	2.48e-02	-0.410000	4.76e-02
CRMPs in Sema3A signaling	16	4.56e-03	-0.410000	1.09e-02
Signaling by TGF-beta Receptor Complex	74	1.66e-09	-0.405000	1.79e-08
Glycolysis	67	9.95e-09	-0.405000	9.62e-08
Signaling by BRAF and RAF1 fusions	60	6.37e-08	-0.403000	5.38e-07
FLT3 signaling in disease	28	2.34e-04	-0.402000	8.16e-04
G alpha (z) signalling events	40	1.12e-05	-0.401000	5.19e-05
Membrane Trafficking	581	9.61e-62	-0.401000	7.11e-59
Cellular response to starvation	150	2.52e-17	0.400000	6.43e-16
COPII-mediated vesicle transport	66	1.94e-08	-0.400000	1.81e-07
Regulation of IFNA signaling	12	1.66e-02	-0.399000	3.38e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	4.23e-04	-0.399000	1.39e-03
rRNA processing in the nucleus and cytosol	190	2.56e-21	0.398000	1.02e-19
Receptor-type tyrosine-protein phosphatases	18	3.46e-03	-0.398000	8.72e-03
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	94	2.72e-11	-0.397000	3.80e-10
Negative regulation of the PI3K/AKT network	101	5.32e-12	-0.397000	8.47e-11
Signaling by NTRK2 (TRKB)	24	7.68e-04	-0.397000	2.32e-03
Role of phospholipids in phagocytosis	22	1.28e-03	-0.397000	3.61e-03
EPHA-mediated growth cone collapse	15	7.88e-03	-0.396000	1.76e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	4.36e-06	-0.396000	2.27e-05
Influenza Viral RNA Transcription and Replication	134	2.70e-15	0.395000	6.05e-14
FGFR1 mutant receptor activation	29	2.34e-04	-0.395000	8.16e-04
ECM proteoglycans	45	4.85e-06	-0.394000	2.46e-05
Sphingolipid de novo biosynthesis	42	1.16e-05	-0.391000	5.34e-05
FCERI mediated MAPK activation	29	2.71e-04	-0.391000	9.25e-04
Interleukin-2 family signaling	35	6.45e-05	-0.390000	2.48e-04
IRE1alpha activates chaperones	50	1.82e-06	-0.390000	1.03e-05
Signal amplification	28	3.54e-04	-0.390000	1.18e-03
Prolactin receptor signaling	11	2.52e-02	-0.390000	4.81e-02
Translation of Replicase and Assembly of the Replication Transcription Complex	13	1.53e-02	-0.388000	3.16e-02
Signaling by NOTCH1	72	1.25e-08	-0.388000	1.20e-07
Transcriptional activation of mitochondrial biogenesis	53	1.09e-06	-0.387000	6.72e-06
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	6.16e-05	-0.386000	2.38e-04
Signaling by FGFR1 in disease	36	6.20e-05	-0.386000	2.39e-04
DAP12 interactions	34	9.97e-05	-0.386000	3.72e-04
AKT phosphorylates targets in the cytosol	14	1.26e-02	-0.385000	2.67e-02
SUMOylation of intracellular receptors	27	5.39e-04	-0.385000	1.72e-03
Apoptotic execution phase	47	5.08e-06	-0.384000	2.58e-05
Carnitine metabolism	11	2.73e-02	-0.384000	5.15e-02
Gap junction assembly	10	3.54e-02	-0.384000	6.44e-02
The citric acid (TCA) cycle and respiratory electron transport	173	2.57e-18	0.384000	7.31e-17
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.76e-02	-0.384000	5.19e-02
Transport of Ribonucleoproteins into the Host Nucleus	32	1.74e-04	-0.383000	6.21e-04
Signaling by TGFB family members	98	5.31e-11	-0.383000	6.83e-10
Cell junction organization	78	5.27e-09	-0.382000	5.23e-08
Golgi-to-ER retrograde transport	111	3.55e-12	-0.382000	5.90e-11
FLT3 Signaling	37	6.07e-05	-0.381000	2.36e-04
Vesicle-mediated transport	612	1.01e-58	-0.381000	4.99e-56
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	5.93e-07	0.379000	4.01e-06
SHC1 events in ERBB2 signaling	21	2.67e-03	-0.379000	6.89e-03
XBP1(S) activates chaperone genes	48	5.81e-06	-0.378000	2.93e-05
EPH-ephrin mediated repulsion of cells	48	5.97e-06	-0.378000	2.98e-05
Interleukin-17 signaling	67	9.22e-08	-0.377000	7.41e-07
Signaling by NTRKs	133	5.83e-14	-0.377000	1.23e-12
Negative regulation of MAPK pathway	42	2.38e-05	-0.377000	1.03e-04
Dissolution of Fibrin Clot	12	2.40e-02	-0.376000	4.63e-02
Fatty acyl-CoA biosynthesis	35	1.18e-04	-0.376000	4.31e-04
activated TAK1 mediates p38 MAPK activation	18	5.92e-03	-0.375000	1.37e-02
Elevation of cytosolic Ca2+ levels	13	1.98e-02	-0.373000	3.95e-02
NOTCH1 Intracellular Domain Regulates Transcription	47	9.66e-06	-0.373000	4.62e-05
Chondroitin sulfate/dermatan sulfate metabolism	48	8.15e-06	-0.372000	3.98e-05
WNT ligand biogenesis and trafficking	24	1.61e-03	-0.372000	4.42e-03
Signaling by NTRK1 (TRKA)	115	6.18e-12	-0.371000	9.53e-11
Gap junction trafficking	19	5.15e-03	-0.371000	1.22e-02
Ribosomal scanning and start codon recognition	57	1.28e-06	0.371000	7.71e-06
EPH-Ephrin signaling	91	9.82e-10	-0.370000	1.08e-08
Effects of PIP2 hydrolysis	24	1.71e-03	-0.370000	4.63e-03
Translation initiation complex formation	57	1.40e-06	0.369000	8.33e-06
mRNA decay by 3’ to 5’ exoribonuclease	16	1.07e-02	0.368000	2.31e-02
HuR (ELAVL1) binds and stabilizes mRNA	10	4.42e-02	-0.368000	7.82e-02
CD28 dependent PI3K/Akt signaling	19	5.59e-03	-0.367000	1.31e-02
TBC/RABGAPs	43	3.20e-05	-0.366000	1.34e-04
Spry regulation of FGF signaling	16	1.13e-02	-0.366000	2.42e-02
ATF4 activates genes in response to endoplasmic reticulum stress	26	1.26e-03	0.365000	3.58e-03
Semaphorin interactions	60	9.93e-07	-0.365000	6.17e-06
DAP12 signaling	27	1.04e-03	-0.365000	3.03e-03
Disorders of Developmental Biology	13	2.37e-02	-0.362000	4.58e-02
Disorders of Nervous System Development	13	2.37e-02	-0.362000	4.58e-02
Loss of function of MECP2 in Rett syndrome	13	2.37e-02	-0.362000	4.58e-02
Pervasive developmental disorders	13	2.37e-02	-0.362000	4.58e-02
Phosphorylation of the APC/C	20	5.05e-03	0.362000	1.20e-02
AKT phosphorylates targets in the nucleus	10	4.77e-02	-0.362000	8.39e-02
WNT5A-dependent internalization of FZD4	15	1.54e-02	-0.361000	3.16e-02
N-glycan antennae elongation in the medial/trans-Golgi	25	1.77e-03	-0.361000	4.79e-03
NRAGE signals death through JNK	59	1.60e-06	-0.361000	9.36e-06
trans-Golgi Network Vesicle Budding	71	1.66e-07	-0.359000	1.24e-06
DNA strand elongation	32	4.65e-04	0.357000	1.51e-03
Asparagine N-linked glycosylation	278	9.61e-25	-0.357000	5.68e-23
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	1.69e-02	-0.356000	3.44e-02
Downregulation of TGF-beta receptor signaling	26	1.67e-03	-0.356000	4.56e-03
Transport of the SLBP independent Mature mRNA	35	2.75e-04	-0.355000	9.36e-04
Interactions of Vpr with host cellular proteins	37	1.85e-04	-0.355000	6.55e-04
TRAF3-dependent IRF activation pathway	14	2.15e-02	-0.355000	4.25e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	2.19e-02	-0.354000	4.31e-02
PPARA activates gene expression	110	1.65e-10	-0.352000	2.02e-09
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	9.81e-03	-0.352000	2.13e-02
NEP/NS2 Interacts with the Cellular Export Machinery	32	5.87e-04	-0.351000	1.85e-03
Vpr-mediated nuclear import of PICs	34	3.96e-04	-0.351000	1.31e-03
Insulin receptor signalling cascade	50	1.78e-05	-0.351000	7.84e-05
PI3K/AKT Signaling in Cancer	94	4.15e-09	-0.351000	4.20e-08
Lewis blood group biosynthesis	15	1.89e-02	-0.350000	3.78e-02
Retrograde neurotrophin signalling	14	2.36e-02	-0.349000	4.58e-02
Adherens junctions interactions	29	1.14e-03	-0.349000	3.26e-03
RAB GEFs exchange GTP for GDP on RABs	88	1.49e-08	-0.349000	1.41e-07
NOTCH4 Intracellular Domain Regulates Transcription	19	8.55e-03	-0.348000	1.88e-02
Signaling by RAF1 mutants	37	2.48e-04	-0.348000	8.58e-04
Transport of the SLBP Dependant Mature mRNA	36	3.04e-04	-0.348000	1.03e-03
MyD88 cascade initiated on plasma membrane	80	7.51e-08	-0.348000	6.17e-07
Toll Like Receptor 10 (TLR10) Cascade	80	7.51e-08	-0.348000	6.17e-07
Toll Like Receptor 5 (TLR5) Cascade	80	7.51e-08	-0.348000	6.17e-07
Regulation of lipid metabolism by PPARalpha	112	2.21e-10	-0.347000	2.62e-09
Ovarian tumor domain proteases	37	2.69e-04	-0.346000	9.22e-04
Export of Viral Ribonucleoproteins from Nucleus	33	5.87e-04	-0.346000	1.85e-03
Platelet Aggregation (Plug Formation)	32	7.13e-04	-0.346000	2.19e-03
Synaptic adhesion-like molecules	21	6.16e-03	-0.345000	1.42e-02
Cytosolic iron-sulfur cluster assembly	13	3.12e-02	0.345000	5.81e-02
Synthesis of very long-chain fatty acyl-CoAs	22	5.11e-03	-0.345000	1.21e-02
Endosomal/Vacuolar pathway	12	3.89e-02	-0.344000	6.97e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	11	4.87e-02	-0.343000	8.54e-02
Attenuation phase	23	4.44e-03	-0.343000	1.07e-02
APC-Cdc20 mediated degradation of Nek2A	26	2.52e-03	0.342000	6.56e-03
APC/C:Cdc20 mediated degradation of Securin	66	1.56e-06	0.342000	9.25e-06
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	35	4.73e-04	-0.341000	1.54e-03
Toll Like Receptor 3 (TLR3) Cascade	89	2.71e-08	-0.341000	2.47e-07
LDL clearance	16	1.84e-02	-0.340000	3.69e-02
COPI-dependent Golgi-to-ER retrograde traffic	78	2.14e-07	-0.339000	1.55e-06
Nucleotide biosynthesis	12	4.24e-02	-0.338000	7.56e-02
Citric acid cycle (TCA cycle)	22	6.13e-03	-0.338000	1.41e-02
G alpha (12/13) signalling events	75	4.33e-07	-0.337000	2.99e-06
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.00e-03	-0.336000	2.94e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.00e-03	-0.336000	2.94e-03
Translocation of ZAP-70 to Immunological synapse	15	2.43e-02	0.336000	4.68e-02
SARS-CoV-2 Infection	71	9.85e-07	-0.336000	6.15e-06
RNA Polymerase I Promoter Opening	25	3.68e-03	0.336000	9.18e-03
Pre-NOTCH Processing in Golgi	18	1.38e-02	-0.335000	2.87e-02
Signaling by Receptor Tyrosine Kinases	480	1.62e-36	-0.335000	2.66e-34
Toll Like Receptor 9 (TLR9) Cascade	90	4.31e-08	-0.334000	3.71e-07
Caspase activation via extrinsic apoptotic signalling pathway	25	3.87e-03	-0.334000	9.62e-03
Signaling by Rho GTPases	629	1.15e-46	-0.334000	2.43e-44
Autodegradation of Cdh1 by Cdh1:APC/C	64	4.18e-06	0.332000	2.20e-05
Diseases of signal transduction by growth factor receptors and second messengers	411	4.45e-31	-0.332000	5.99e-29
RHOBTB GTPase Cycle	35	6.65e-04	-0.332000	2.06e-03
Deactivation of the beta-catenin transactivating complex	41	2.34e-04	-0.332000	8.16e-04
Glucagon signaling in metabolic regulation	26	3.41e-03	-0.332000	8.61e-03
Transcriptional Regulation by MECP2	55	2.10e-05	-0.331000	9.18e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	645	3.62e-47	-0.331000	8.93e-45
Extracellular matrix organization	256	7.37e-20	-0.331000	2.48e-18
HSF1-dependent transactivation	31	1.48e-03	-0.330000	4.10e-03
DNA methylation	27	3.01e-03	0.330000	7.67e-03
Interleukin-20 family signaling	19	1.29e-02	-0.330000	2.70e-02
Rab regulation of trafficking	120	4.34e-10	-0.330000	4.94e-09
Integrin cell surface interactions	60	1.03e-05	-0.329000	4.85e-05
Clathrin-mediated endocytosis	138	2.98e-11	-0.327000	4.11e-10
Initial triggering of complement	15	2.81e-02	0.327000	5.29e-02
Glycogen breakdown (glycogenolysis)	15	2.83e-02	-0.327000	5.32e-02
IGF1R signaling cascade	49	7.55e-05	-0.327000	2.88e-04
Platelet activation, signaling and aggregation	230	1.57e-17	-0.326000	4.15e-16
Rap1 signalling	15	2.93e-02	-0.325000	5.49e-02
Constitutive Signaling by Aberrant PI3K in Cancer	67	4.37e-06	-0.324000	2.27e-05
Platelet homeostasis	73	1.65e-06	-0.324000	9.61e-06
Translesion synthesis by POLI	17	2.07e-02	0.324000	4.09e-02
Diseases associated with visual transduction	10	7.60e-02	0.324000	1.26e-01
Diseases of the neuronal system	10	7.60e-02	0.324000	1.26e-01
Retinoid cycle disease events	10	7.60e-02	0.324000	1.26e-01
RAB geranylgeranylation	62	1.07e-05	-0.323000	5.04e-05
MyD88-independent TLR4 cascade	93	7.64e-08	-0.322000	6.20e-07
TRIF(TICAM1)-mediated TLR4 signaling	93	7.64e-08	-0.322000	6.20e-07
Processing and activation of SUMO	10	7.80e-02	-0.322000	1.29e-01
p75 NTR receptor-mediated signalling	95	5.94e-08	-0.322000	5.05e-07
Transport of bile salts and organic acids, metal ions and amine compounds	61	1.40e-05	-0.321000	6.36e-05
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	85	3.01e-07	-0.321000	2.14e-06
TGF-beta receptor signaling activates SMADs	32	1.67e-03	-0.321000	4.56e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	2.59e-06	0.320000	1.41e-05
SUMOylation of SUMOylation proteins	35	1.04e-03	-0.320000	3.03e-03
Translation	293	4.91e-21	0.319000	1.73e-19
ADP signalling through P2Y purinoceptor 1	21	1.16e-02	-0.318000	2.47e-02
Sialic acid metabolism	31	2.18e-03	-0.318000	5.78e-03
Mitochondrial protein import	64	1.09e-05	0.318000	5.08e-05
Cargo recognition for clathrin-mediated endocytosis	100	4.03e-08	-0.317000	3.53e-07
Thrombin signalling through proteinase activated receptors (PARs)	27	4.31e-03	-0.317000	1.05e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.08e-04	0.316000	3.98e-04
p53-Independent DNA Damage Response	50	1.08e-04	0.316000	3.98e-04
p53-Independent G1/S DNA damage checkpoint	50	1.08e-04	0.316000	3.98e-04
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	3.59e-05	-0.316000	1.48e-04
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	3.59e-05	-0.316000	1.48e-04
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	3.59e-05	-0.316000	1.48e-04
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	3.59e-05	-0.316000	1.48e-04
Signaling by NOTCH1 in Cancer	57	3.59e-05	-0.316000	1.48e-04
CDT1 association with the CDC6:ORC:origin complex	57	3.62e-05	0.316000	1.48e-04
Influenza Infection	153	1.44e-11	0.316000	2.16e-10
Nuclear Receptor transcription pathway	46	2.08e-04	-0.316000	7.29e-04
SUMOylation of ubiquitinylation proteins	39	6.42e-04	-0.316000	1.99e-03
IRS-related events triggered by IGF1R	48	1.55e-04	-0.316000	5.57e-04
Signaling by ERBB2 in Cancer	25	6.33e-03	-0.315000	1.46e-02
mRNA Splicing - Minor Pathway	52	8.30e-05	0.315000	3.13e-04
The role of Nef in HIV-1 replication and disease pathogenesis	24	7.48e-03	-0.315000	1.70e-02
Fanconi Anemia Pathway	36	1.10e-03	0.314000	3.16e-03
Transcriptional regulation of white adipocyte differentiation	81	1.13e-06	-0.313000	6.93e-06
Repression of WNT target genes	14	4.34e-02	-0.312000	7.70e-02
Integration of energy metabolism	93	2.04e-07	-0.312000	1.50e-06
PI3K events in ERBB2 signaling	15	3.75e-02	-0.310000	6.78e-02
MyD88 dependent cascade initiated on endosome	86	6.62e-07	-0.310000	4.28e-06
Toll Like Receptor 7/8 (TLR7/8) Cascade	86	6.62e-07	-0.310000	4.28e-06
Assembly and cell surface presentation of NMDA receptors	23	1.02e-02	-0.310000	2.20e-02
Vif-mediated degradation of APOBEC3G	52	1.15e-04	0.309000	4.23e-04
Blood group systems biosynthesis	19	1.98e-02	-0.309000	3.95e-02
Cellular response to heat stress	94	2.34e-07	-0.308000	1.68e-06
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	50	1.64e-04	-0.308000	5.90e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	74	4.62e-06	0.308000	2.39e-05
SHC1 events in EGFR signaling	14	4.62e-02	-0.308000	8.16e-02
Metabolism of carbohydrates	263	8.02e-18	-0.307000	2.16e-16
NR1H2 and NR1H3-mediated signaling	43	4.88e-04	-0.307000	1.58e-03
Regulation of TP53 Activity through Acetylation	29	4.38e-03	-0.306000	1.06e-02
Vasopressin regulates renal water homeostasis via Aquaporins	35	1.78e-03	-0.305000	4.82e-03
Signaling by high-kinase activity BRAF mutants	33	2.42e-03	-0.305000	6.35e-03
Biotin transport and metabolism	11	8.03e-02	-0.304000	1.33e-01
SARS-CoV Infections	151	1.03e-10	-0.304000	1.28e-09
Sphingolipid metabolism	84	1.44e-06	-0.304000	8.55e-06
Cell surface interactions at the vascular wall	100	1.56e-07	-0.303000	1.17e-06
Autodegradation of the E3 ubiquitin ligase COP1	49	2.42e-04	0.303000	8.40e-04
PI-3K cascade:FGFR3	16	3.59e-02	-0.303000	6.52e-02
Translesion synthesis by REV1	16	3.62e-02	0.303000	6.55e-02
Sensory processing of sound by outer hair cells of the cochlea	44	5.20e-04	-0.302000	1.67e-03
Signaling by FGFR3	38	1.26e-03	-0.302000	3.58e-03
NS1 Mediated Effects on Host Pathways	40	9.45e-04	-0.302000	2.82e-03
Costimulation by the CD28 family	59	6.23e-05	-0.301000	2.40e-04
Nuclear Events (kinase and transcription factor activation)	62	4.24e-05	-0.301000	1.70e-04
Negative regulation of NMDA receptor-mediated neuronal transmission	19	2.34e-02	-0.300000	4.57e-02
Ras activation upon Ca2+ influx through NMDA receptor	18	2.75e-02	-0.300000	5.19e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	8.50e-02	-0.300000	1.38e-01
Nuclear Envelope Breakdown	53	1.62e-04	-0.299000	5.82e-04
Leishmania infection	189	1.23e-12	-0.299000	2.20e-11
DSCAM interactions	10	1.02e-01	-0.299000	1.61e-01
Signaling by FGFR1	47	3.94e-04	-0.299000	1.30e-03
Digestion and absorption	11	8.69e-02	0.298000	1.41e-01
Cell death signalling via NRAGE, NRIF and NADE	76	7.25e-06	-0.297000	3.56e-05
IRS-mediated signalling	45	5.59e-04	-0.297000	1.77e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.00e-03	-0.297000	2.94e-03
Signaling by RAS mutants	41	1.00e-03	-0.297000	2.94e-03
Signaling by moderate kinase activity BRAF mutants	41	1.00e-03	-0.297000	2.94e-03
Signaling downstream of RAS mutants	41	1.00e-03	-0.297000	2.94e-03
Protein-protein interactions at synapses	78	5.93e-06	-0.296000	2.98e-05
SLBP independent Processing of Histone Pre-mRNAs	10	1.05e-01	0.296000	1.65e-01
Assembly of active LPL and LIPC lipase complexes	13	6.45e-02	-0.296000	1.09e-01
Hemostasis	495	1.11e-29	-0.296000	1.17e-27
Negative regulation of MET activity	21	1.88e-02	-0.296000	3.77e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	34	2.82e-03	-0.296000	7.24e-03
PI-3K cascade:FGFR1	19	2.56e-02	-0.296000	4.90e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	9.42e-06	0.296000	4.53e-05
TNFR1-induced proapoptotic signaling	13	6.50e-02	-0.296000	1.10e-01
Synthesis of DNA	118	3.07e-08	0.295000	2.73e-07
Inositol phosphate metabolism	45	6.37e-04	-0.294000	1.98e-03
Glutamate binding, activation of AMPA receptors and synaptic plasticity	27	8.32e-03	-0.293000	1.85e-02
Trafficking of AMPA receptors	27	8.32e-03	-0.293000	1.85e-02
ISG15 antiviral mechanism	72	1.67e-05	-0.293000	7.45e-05
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.32e-02	0.293000	4.55e-02
Class I peroxisomal membrane protein import	19	2.71e-02	-0.293000	5.13e-02
Diseases associated with glycosylation precursor biosynthesis	18	3.15e-02	-0.293000	5.83e-02
Long-term potentiation	20	2.34e-02	-0.293000	4.57e-02
Death Receptor Signalling	138	2.90e-09	-0.292000	3.07e-08
SHC1 events in ERBB4 signaling	13	6.86e-02	-0.292000	1.15e-01
Downstream signaling of activated FGFR3	23	1.55e-02	-0.292000	3.18e-02
DNA Replication	151	6.63e-10	0.291000	7.37e-09
Signaling by ERBB2 KD Mutants	24	1.37e-02	-0.291000	2.86e-02
Listeria monocytogenes entry into host cells	20	2.45e-02	-0.290000	4.72e-02
Physiological factors	10	1.12e-01	-0.290000	1.75e-01
Glucose metabolism	84	4.31e-06	-0.290000	2.25e-05
Assembly of the pre-replicative complex	91	1.76e-06	0.290000	1.00e-05
TRAF6 mediated IRF7 activation	16	4.50e-02	-0.290000	7.95e-02
Deposition of new CENPA-containing nucleosomes at the centromere	45	7.88e-04	0.289000	2.37e-03
Nucleosome assembly	45	7.88e-04	0.289000	2.37e-03
FOXO-mediated transcription	59	1.22e-04	-0.289000	4.45e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	2.21e-05	0.289000	9.63e-05
CDK-mediated phosphorylation and removal of Cdc6	71	2.58e-05	0.289000	1.11e-04
Nuclear Pore Complex (NPC) Disassembly	36	2.79e-03	-0.288000	7.18e-03
DNA Replication Pre-Initiation	108	2.32e-07	0.288000	1.67e-06
Lagging Strand Synthesis	20	2.61e-02	0.287000	4.97e-02
EGFR downregulation	31	5.65e-03	-0.287000	1.32e-02
ESR-mediated signaling	174	6.10e-11	-0.287000	7.78e-10
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	5.92e-04	0.287000	1.86e-03
Antiviral mechanism by IFN-stimulated genes	80	9.39e-06	-0.286000	4.53e-05
PI3K Cascade	41	1.52e-03	-0.286000	4.17e-03
Formation of the cornified envelope	22	2.02e-02	-0.286000	3.99e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	3.39e-03	-0.286000	8.58e-03
Activation of the pre-replicative complex	33	4.49e-03	0.286000	1.08e-02
Lysosphingolipid and LPA receptors	11	1.01e-01	-0.286000	1.60e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	1.35e-03	-0.286000	3.78e-03
CDC6 association with the ORC:origin complex	11	1.01e-01	0.286000	1.60e-01
Negative regulation of NOTCH4 signaling	54	2.80e-04	0.286000	9.53e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	3.18e-05	0.285000	1.33e-04
Depolymerisation of the Nuclear Lamina	15	5.57e-02	-0.285000	9.63e-02
Cargo trafficking to the periciliary membrane	47	7.15e-04	-0.285000	2.19e-03
Stabilization of p53	53	3.29e-04	0.285000	1.11e-03
Nuclear import of Rev protein	34	4.03e-03	-0.285000	9.96e-03
Interleukin-6 family signaling	23	1.83e-02	-0.284000	3.68e-02
SUMOylation of transcription cofactors	44	1.11e-03	-0.284000	3.21e-03
KSRP (KHSRP) binds and destabilizes mRNA	17	4.27e-02	0.284000	7.60e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	8.95e-02	-0.283000	1.44e-01
alpha-linolenic acid (ALA) metabolism	12	8.95e-02	-0.283000	1.44e-01
Cell-cell junction organization	53	3.70e-04	-0.283000	1.23e-03
Neurexins and neuroligins	49	6.34e-04	-0.282000	1.98e-03
Activated NOTCH1 Transmits Signal to the Nucleus	30	7.62e-03	-0.281000	1.72e-02
PKMTs methylate histone lysines	45	1.09e-03	-0.281000	3.14e-03
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.42e-03	-0.281000	3.96e-03
Phospholipid metabolism	192	1.80e-11	-0.281000	2.63e-10
Amine ligand-binding receptors	23	1.99e-02	-0.280000	3.95e-02
Rev-mediated nuclear export of HIV RNA	35	4.09e-03	-0.280000	1.01e-02
RHO GTPases activate PAKs	21	2.65e-02	-0.280000	5.04e-02
PCNA-Dependent Long Patch Base Excision Repair	21	2.66e-02	0.279000	5.05e-02
Leading Strand Synthesis	14	7.02e-02	0.279000	1.18e-01
Polymerase switching	14	7.02e-02	0.279000	1.18e-01
Association of TriC/CCT with target proteins during biosynthesis	37	3.27e-03	-0.279000	8.32e-03
Potential therapeutics for SARS	82	1.23e-05	-0.279000	5.63e-05
Signal Transduction	2189	0.00e+00	-0.279000	0.00e+00
Downstream signaling of activated FGFR1	29	9.57e-03	-0.278000	2.09e-02
Signaling by ERBB2	49	7.72e-04	-0.278000	2.33e-03
Processive synthesis on the lagging strand	15	6.28e-02	0.277000	1.07e-01
Aquaporin-mediated transport	39	2.72e-03	-0.277000	7.01e-03
Postmitotic nuclear pore complex (NPC) reformation	27	1.27e-02	-0.277000	2.68e-02
FOXO-mediated transcription of cell death genes	15	6.32e-02	-0.277000	1.07e-01
Receptor Mediated Mitophagy	11	1.13e-01	-0.276000	1.76e-01
Uptake and actions of bacterial toxins	29	1.02e-02	-0.276000	2.20e-02
Metabolism of fat-soluble vitamins	36	4.26e-03	-0.275000	1.04e-02
Defective pyroptosis	35	4.86e-03	0.275000	1.16e-02
Intracellular signaling by second messengers	292	6.06e-16	-0.275000	1.42e-14
Regulation of pyruvate dehydrogenase (PDH) complex	15	6.64e-02	-0.274000	1.12e-01
HSF1 activation	26	1.59e-02	-0.273000	3.26e-02
Ion homeostasis	45	1.53e-03	-0.273000	4.21e-03
RHO GTPases activate CIT	19	3.96e-02	-0.273000	7.09e-02
Condensation of Prometaphase Chromosomes	11	1.17e-01	0.273000	1.81e-01
O-linked glycosylation of mucins	52	6.75e-04	-0.272000	2.08e-03
RHOBTB1 GTPase cycle	23	2.38e-02	-0.272000	4.60e-02
Defects in vitamin and cofactor metabolism	21	3.12e-02	-0.271000	5.81e-02
Mucopolysaccharidoses	11	1.20e-01	-0.271000	1.83e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	58	3.72e-04	0.270000	1.23e-03
GRB2 events in ERBB2 signaling	15	7.04e-02	-0.270000	1.18e-01
Regulation of HSF1-mediated heat shock response	78	3.98e-05	-0.269000	1.61e-04
Activation of the TFAP2 (AP-2) family of transcription factors	11	1.24e-01	-0.268000	1.89e-01
G-protein beta:gamma signalling	27	1.59e-02	-0.268000	3.25e-02
Ion transport by P-type ATPases	47	1.50e-03	-0.268000	4.13e-03
Switching of origins to a post-replicative state	89	1.27e-05	0.268000	5.77e-05
Signaling by Non-Receptor Tyrosine Kinases	53	7.49e-04	-0.268000	2.28e-03
Signaling by PTK6	53	7.49e-04	-0.268000	2.28e-03
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	3.83e-02	0.267000	6.91e-02
Vpu mediated degradation of CD4	50	1.08e-03	0.267000	3.12e-03
Regulation of insulin secretion	65	1.99e-04	-0.267000	7.01e-04
Synthesis of IP2, IP, and Ins in the cytosol	14	8.41e-02	-0.267000	1.37e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	3.47e-02	0.266000	6.35e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	3.47e-02	0.266000	6.35e-02
ER Quality Control Compartment (ERQC)	21	3.52e-02	-0.265000	6.43e-02
Defective GALNT12 causes CRCS1	12	1.11e-01	0.265000	1.74e-01
GRB2 events in EGFR signaling	13	9.79e-02	-0.265000	1.56e-01
Ubiquitin-dependent degradation of Cyclin D	50	1.20e-03	0.265000	3.42e-03
Interactions of Rev with host cellular proteins	37	5.41e-03	-0.264000	1.27e-02
SUMOylation of chromatin organization proteins	57	5.59e-04	-0.264000	1.77e-03
Lysosome Vesicle Biogenesis	34	7.70e-03	-0.264000	1.73e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.27e-02	0.263000	4.46e-02
Thromboxane signalling through TP receptor	20	4.20e-02	-0.263000	7.51e-02
eNOS activation	11	1.33e-01	-0.262000	2.01e-01
Factors involved in megakaryocyte development and platelet production	116	1.10e-06	-0.262000	6.78e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.33e-01	0.262000	2.01e-01
SUMOylation of transcription factors	19	4.85e-02	-0.261000	8.52e-02
Neurotransmitter receptors and postsynaptic signal transmission	155	2.06e-08	-0.261000	1.91e-07
Autophagy	125	5.14e-07	-0.260000	3.52e-06
MHC class II antigen presentation	98	8.80e-06	-0.260000	4.28e-05
Toll Like Receptor 4 (TLR4) Cascade	122	7.93e-07	-0.259000	5.08e-06
Toll-like Receptor Cascades	140	1.26e-07	-0.259000	9.91e-07
Regulation of TP53 Expression and Degradation	36	7.41e-03	-0.258000	1.69e-02
The NLRP3 inflammasome	15	8.48e-02	-0.257000	1.38e-01
Interleukin-4 and Interleukin-13 signaling	97	1.21e-05	-0.257000	5.55e-05
Regulation of beta-cell development	31	1.34e-02	-0.256000	2.82e-02
Activation of the AP-1 family of transcription factors	10	1.60e-01	-0.256000	2.35e-01
Glutathione synthesis and recycling	12	1.24e-01	0.256000	1.90e-01
Collagen degradation	35	8.75e-03	-0.256000	1.92e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.32e-03	0.255000	3.70e-03
Retinoid metabolism and transport	32	1.27e-02	-0.254000	2.68e-02
CS/DS degradation	13	1.12e-01	-0.254000	1.75e-01
Endogenous sterols	22	3.91e-02	-0.254000	7.01e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	31	1.49e-02	-0.253000	3.10e-02
Response to elevated platelet cytosolic Ca2+	117	2.35e-06	-0.252000	1.29e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.49e-03	0.252000	4.12e-03
Regulation of TLR by endogenous ligand	15	9.18e-02	0.251000	1.47e-01
MAPK family signaling cascades	299	7.30e-14	-0.251000	1.52e-12
Macroautophagy	111	4.80e-06	-0.251000	2.45e-05
Trafficking of GluR2-containing AMPA receptors	16	8.35e-02	-0.250000	1.37e-01
SUMOylation of DNA damage response and repair proteins	76	1.65e-04	-0.250000	5.90e-04
Activation of BH3-only proteins	29	1.99e-02	-0.250000	3.95e-02
Synthesis of IP3 and IP4 in the cytosol	24	3.43e-02	-0.250000	6.29e-02
Signaling by FGFR4	38	7.75e-03	-0.250000	1.74e-02
Signalling to RAS	20	5.35e-02	-0.249000	9.31e-02
SCF-beta-TrCP mediated degradation of Emi1	53	1.69e-03	0.249000	4.61e-03
Calnexin/calreticulin cycle	26	2.79e-02	-0.249000	5.24e-02
Regulation of Apoptosis	51	2.08e-03	0.249000	5.55e-03
Sulfur amino acid metabolism	25	3.13e-02	0.249000	5.81e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	95	2.76e-05	-0.249000	1.17e-04
Toll Like Receptor 2 (TLR2) Cascade	95	2.76e-05	-0.249000	1.17e-04
Toll Like Receptor TLR1:TLR2 Cascade	95	2.76e-05	-0.249000	1.17e-04
Toll Like Receptor TLR6:TLR2 Cascade	95	2.76e-05	-0.249000	1.17e-04
Post-translational protein modification	1270	6.68e-51	-0.249000	1.98e-48
Orc1 removal from chromatin	69	3.62e-04	0.248000	1.20e-03
O-linked glycosylation	99	1.97e-05	-0.248000	8.64e-05
NCAM signaling for neurite out-growth	55	1.46e-03	-0.248000	4.06e-03
Glycogen synthesis	15	9.67e-02	-0.248000	1.54e-01
Platelet degranulation	112	5.95e-06	-0.248000	2.98e-05
SARS-CoV-1 Infection	50	2.62e-03	-0.246000	6.79e-03
RHO GTPases Activate ROCKs	19	6.38e-02	-0.246000	1.08e-01
IRAK1 recruits IKK complex	10	1.79e-01	-0.245000	2.59e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	1.79e-01	-0.245000	2.59e-01
Platelet Adhesion to exposed collagen	11	1.59e-01	-0.245000	2.34e-01
Synthesis of substrates in N-glycan biosythesis	61	9.39e-04	-0.245000	2.81e-03
Signaling by NOTCH2	32	1.65e-02	-0.245000	3.37e-02
G beta:gamma signalling through PI3Kgamma	21	5.25e-02	-0.244000	9.15e-02
Cross-presentation of soluble exogenous antigens (endosomes)	45	4.55e-03	0.244000	1.09e-02
ERBB2 Regulates Cell Motility	14	1.14e-01	-0.244000	1.76e-01
Degradation of the extracellular matrix	94	4.30e-05	-0.244000	1.72e-04
Mitochondrial Fatty Acid Beta-Oxidation	34	1.39e-02	0.244000	2.90e-02
Signaling by ERBB4	52	2.45e-03	-0.243000	6.38e-03
Unblocking of NMDA receptors, glutamate binding and activation	18	7.48e-02	-0.243000	1.25e-01
Translesion synthesis by POLK	17	8.34e-02	0.242000	1.37e-01
Resolution of D-Loop Structures	33	1.61e-02	0.242000	3.30e-02
MAP2K and MAPK activation	37	1.12e-02	-0.241000	2.40e-02
Signaling by FGFR3 in disease	20	6.26e-02	-0.240000	1.07e-01
Signaling by FGFR3 point mutants in cancer	20	6.26e-02	-0.240000	1.07e-01
PIP3 activates AKT signaling	256	3.63e-11	-0.240000	4.92e-10
FGFRL1 modulation of FGFR1 signaling	12	1.51e-01	-0.239000	2.23e-01
G beta:gamma signalling through CDC42	16	9.74e-02	-0.239000	1.55e-01
ADP signalling through P2Y purinoceptor 12	17	8.80e-02	-0.239000	1.42e-01
Negative regulation of FGFR1 signaling	30	2.35e-02	-0.239000	4.57e-02
Regulation of TP53 Degradation	35	1.47e-02	-0.238000	3.05e-02
Negative regulators of DDX58/IFIH1 signaling	35	1.52e-02	-0.237000	3.15e-02
Negative regulation of FGFR3 signaling	27	3.32e-02	-0.237000	6.09e-02
Signaling by NOTCH3	46	5.52e-03	-0.236000	1.29e-02
Hh mutants are degraded by ERAD	54	2.66e-03	0.236000	6.87e-03
Downstream signaling of activated FGFR2	27	3.41e-02	-0.236000	6.25e-02
Signaling by WNT	277	1.44e-11	-0.235000	2.16e-10
FRS-mediated FGFR1 signaling	21	6.24e-02	-0.235000	1.07e-01
Kinesins	39	1.15e-02	-0.234000	2.44e-02
Anti-inflammatory response favouring Leishmania parasite infection	108	2.71e-05	-0.234000	1.16e-04
Leishmania parasite growth and survival	108	2.71e-05	-0.234000	1.16e-04
Signaling by Nuclear Receptors	240	4.50e-10	-0.233000	5.04e-09
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	13	1.46e-01	-0.233000	2.17e-01
Phase 4 - resting membrane potential	16	1.07e-01	-0.233000	1.69e-01
SUMOylation	170	1.63e-07	-0.233000	1.22e-06
APC/C-mediated degradation of cell cycle proteins	86	1.99e-04	0.232000	7.01e-04
Regulation of mitotic cell cycle	86	1.99e-04	0.232000	7.01e-04
PRC2 methylates histones and DNA	35	1.76e-02	0.232000	3.55e-02
RNA Polymerase II Transcription Termination	65	1.24e-03	0.232000	3.52e-03
Removal of the Flap Intermediate	14	1.34e-01	0.231000	2.02e-01
Adaptive Immune System	649	6.04e-24	-0.231000	3.44e-22
Condensation of Prophase Chromosomes	35	1.79e-02	0.231000	3.61e-02
FRS-mediated FGFR3 signaling	18	8.97e-02	-0.231000	1.44e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	5.23e-03	-0.231000	1.23e-02
Nuclear events stimulated by ALK signaling in cancer	19	8.27e-02	-0.230000	1.36e-01
NOD1/2 Signaling Pathway	31	2.71e-02	-0.229000	5.14e-02
Peptide hormone metabolism	69	1.07e-03	-0.228000	3.10e-03
Downstream signaling of activated FGFR4	24	5.52e-02	-0.226000	9.56e-02
Degradation of DVL	55	3.73e-03	0.226000	9.31e-03
p53-Dependent G1 DNA Damage Response	62	2.17e-03	0.225000	5.74e-03
p53-Dependent G1/S DNA damage checkpoint	62	2.17e-03	0.225000	5.74e-03
PI-3K cascade:FGFR2	20	8.15e-02	-0.225000	1.34e-01
SIRT1 negatively regulates rRNA expression	30	3.31e-02	0.225000	6.09e-02
Metabolism of amino acids and derivatives	341	9.19e-13	0.225000	1.68e-11
Transport of vitamins, nucleosides, and related molecules	35	2.15e-02	-0.225000	4.24e-02
SUMOylation of DNA replication proteins	46	8.50e-03	-0.224000	1.88e-02
Glycogen metabolism	26	4.80e-02	-0.224000	8.43e-02
RHOBTB2 GTPase cycle	23	6.32e-02	-0.224000	1.07e-01
Diseases of glycosylation	131	9.71e-06	-0.224000	4.63e-05
RAS processing	19	9.27e-02	-0.223000	1.49e-01
Regulation of APC/C activators between G1/S and early anaphase	79	6.18e-04	0.223000	1.93e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	1.03e-01	0.222000	1.62e-01
Protein ubiquitination	73	1.05e-03	-0.222000	3.04e-03
Regulation of ornithine decarboxylase (ODC)	49	7.28e-03	0.222000	1.66e-02
SUMO E3 ligases SUMOylate target proteins	164	9.64e-07	-0.222000	6.07e-06
Resolution of D-loop Structures through Holliday Junction Intermediates	32	3.02e-02	0.221000	5.63e-02
G1/S DNA Damage Checkpoints	64	2.20e-03	0.221000	5.80e-03
MTOR signalling	40	1.55e-02	-0.221000	3.19e-02
Energy dependent regulation of mTOR by LKB1-AMPK	28	4.32e-02	-0.221000	7.67e-02
RNA Polymerase I Promoter Escape	53	5.49e-03	0.220000	1.29e-02
Neuronal System	331	5.79e-12	-0.220000	9.01e-11
ROS sensing by NFE2L2	55	4.91e-03	0.219000	1.17e-02
Signaling by CSF3 (G-CSF)	30	3.85e-02	-0.218000	6.93e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.31e-01	-0.218000	1.98e-01
STING mediated induction of host immune responses	15	1.43e-01	-0.218000	2.15e-01
Signaling by Insulin receptor	73	1.27e-03	-0.218000	3.58e-03
SLC transporter disorders	84	5.48e-04	-0.218000	1.74e-03
Regulation of PTEN gene transcription	61	3.38e-03	-0.217000	8.56e-03
Metabolism of steroids	138	1.09e-05	-0.217000	5.07e-05
Polo-like kinase mediated events	16	1.33e-01	0.217000	2.02e-01
Glycosphingolipid metabolism	42	1.53e-02	-0.216000	3.16e-02
Selective autophagy	58	4.55e-03	-0.215000	1.09e-02
Metabolism of nitric oxide: NOS3 activation and regulation	15	1.50e-01	-0.215000	2.22e-01
Sensory processing of sound by inner hair cells of the cochlea	58	4.68e-03	-0.215000	1.12e-02
TNFR1-induced NFkappaB signaling pathway	26	5.82e-02	-0.215000	1.00e-01
G alpha (q) signalling events	157	3.53e-06	-0.214000	1.88e-05
Class I MHC mediated antigen processing & presentation	354	4.00e-12	-0.214000	6.58e-11
Inflammasomes	19	1.07e-01	-0.214000	1.68e-01
SUMOylation of RNA binding proteins	47	1.12e-02	-0.214000	2.40e-02
Translation of Structural Proteins	29	4.71e-02	-0.213000	8.28e-02
Signaling by ERBB2 TMD/JMD mutants	21	9.13e-02	-0.213000	1.47e-01
Signaling by ROBO receptors	210	1.13e-07	0.212000	8.98e-07
Antigen processing: Ubiquitination & Proteasome degradation	292	4.38e-10	-0.212000	4.94e-09
MAPK1/MAPK3 signaling	260	5.09e-09	-0.210000	5.08e-08
Activation of ATR in response to replication stress	37	2.73e-02	0.210000	5.15e-02
PI-3K cascade:FGFR4	17	1.35e-01	-0.210000	2.03e-01
RAF/MAP kinase cascade	254	8.86e-09	-0.209000	8.67e-08
Reactions specific to the complex N-glycan synthesis pathway	10	2.53e-01	-0.209000	3.48e-01
Transmission across Chemical Synapses	216	1.23e-07	-0.209000	9.74e-07
SCF(Skp2)-mediated degradation of p27/p21	60	5.41e-03	0.208000	1.27e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	1.08e-01	-0.207000	1.70e-01
RHOBTB3 ATPase cycle	10	2.57e-01	-0.207000	3.53e-01
Hh mutants abrogate ligand secretion	57	6.87e-03	0.207000	1.57e-02
SHC-mediated cascade:FGFR1	19	1.21e-01	-0.206000	1.85e-01
Immune System	1645	1.70e-44	-0.205000	3.15e-42
Cytochrome c-mediated apoptotic response	13	2.00e-01	-0.205000	2.87e-01
Purine salvage	12	2.18e-01	-0.205000	3.07e-01
Degradation of cysteine and homocysteine	11	2.39e-01	0.205000	3.32e-01
Metabolism of lipids	661	2.49e-19	-0.204000	8.02e-18
NIK–>noncanonical NF-kB signaling	57	7.77e-03	0.204000	1.74e-02
Meiotic recombination	46	1.72e-02	0.203000	3.49e-02
IRAK2 mediated activation of TAK1 complex	10	2.67e-01	-0.203000	3.62e-01
Signaling by FGFR in disease	60	6.69e-03	-0.202000	1.53e-02
Chromosome Maintenance	110	2.56e-04	0.202000	8.84e-04
Synthesis of PA	33	4.51e-02	-0.202000	7.96e-02
CASP8 activity is inhibited	10	2.70e-01	-0.202000	3.63e-01
Dimerization of procaspase-8	10	2.70e-01	-0.202000	3.63e-01
Regulation by c-FLIP	10	2.70e-01	-0.202000	3.63e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	1.19e-01	-0.201000	1.82e-01
Neurodegenerative Diseases	20	1.19e-01	-0.201000	1.82e-01
MyD88 deficiency (TLR2/4)	15	1.77e-01	0.201000	2.57e-01
Degradation of AXIN	53	1.12e-02	0.201000	2.40e-02
SLC-mediated transmembrane transport	200	9.27e-07	-0.201000	5.86e-06
Phospholipase C-mediated cascade; FGFR4	12	2.28e-01	0.201000	3.20e-01
Signaling by GPCR	486	3.00e-14	-0.201000	6.42e-13
Triglyceride catabolism	18	1.40e-01	-0.201000	2.11e-01
Sensory processing of sound	63	5.89e-03	-0.201000	1.37e-02
PERK regulates gene expression	31	5.41e-02	0.200000	9.39e-02
GPCR downstream signalling	431	1.03e-12	-0.200000	1.86e-11
Activation of GABAB receptors	36	3.81e-02	-0.200000	6.88e-02
GABA B receptor activation	36	3.81e-02	-0.200000	6.88e-02
Interaction between L1 and Ankyrins	26	7.87e-02	-0.199000	1.30e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	2.53e-01	-0.199000	3.48e-01
Degradation of GLI2 by the proteasome	57	9.49e-03	0.199000	2.07e-02
RHO GTPases Activate NADPH Oxidases	21	1.15e-01	-0.198000	1.78e-01
InlB-mediated entry of Listeria monocytogenes into host cell	15	1.84e-01	-0.198000	2.65e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	89	1.24e-03	0.198000	3.53e-03
Pyrimidine salvage	10	2.80e-01	0.197000	3.75e-01
Pexophagy	11	2.57e-01	-0.197000	3.53e-01
ADORA2B mediated anti-inflammatory cytokines production	82	2.02e-03	-0.197000	5.42e-03
mRNA 3’-end processing	56	1.09e-02	0.197000	2.35e-02
G-protein activation	18	1.49e-01	-0.196000	2.21e-01
Degradation of GLI1 by the proteasome	57	1.04e-02	0.196000	2.24e-02
SHC-mediated cascade:FGFR3	16	1.75e-01	-0.196000	2.54e-01
Antimicrobial peptides	26	8.43e-02	0.196000	1.38e-01
HCMV Infection	106	5.13e-04	-0.195000	1.65e-03
Negative regulation of FGFR2 signaling	31	6.01e-02	-0.195000	1.03e-01
Methylation	14	2.07e-01	0.195000	2.95e-01
Chemokine receptors bind chemokines	25	9.22e-02	0.195000	1.48e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.54e-02	-0.194000	3.16e-02
mTORC1-mediated signalling	24	1.00e-01	-0.194000	1.59e-01
Detoxification of Reactive Oxygen Species	31	6.26e-02	0.193000	1.07e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	1.45e-01	-0.193000	2.17e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	1.45e-01	-0.193000	2.17e-01
Intrinsic Pathway for Apoptosis	53	1.55e-02	-0.192000	3.19e-02
BBSome-mediated cargo-targeting to cilium	21	1.28e-01	-0.192000	1.94e-01
Regulation of IFNG signaling	13	2.31e-01	-0.192000	3.23e-01
Nuclear signaling by ERBB4	27	8.49e-02	-0.192000	1.38e-01
HDR through Homologous Recombination (HRR)	66	7.28e-03	0.191000	1.66e-02
Basigin interactions	23	1.14e-01	-0.190000	1.76e-01
G1/S-Specific Transcription	29	7.62e-02	0.190000	1.26e-01
RHO GTPase Effectors	257	1.55e-07	-0.190000	1.17e-06
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	2.36e-01	0.190000	3.29e-01
Cell recruitment (pro-inflammatory response)	23	1.15e-01	-0.190000	1.78e-01
Purinergic signaling in leishmaniasis infection	23	1.15e-01	-0.190000	1.78e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	11	2.76e-01	-0.190000	3.71e-01
Protein methylation	15	2.04e-01	-0.190000	2.92e-01
p38MAPK events	13	2.38e-01	-0.189000	3.31e-01
Defective GALNT3 causes HFTC	12	2.58e-01	0.188000	3.53e-01
Peroxisomal protein import	59	1.24e-02	-0.188000	2.63e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	33	6.16e-02	-0.188000	1.06e-01
Dectin-1 mediated noncanonical NF-kB signaling	59	1.27e-02	0.188000	2.67e-02
HCMV Early Events	82	3.35e-03	-0.187000	8.50e-03
Telomere Maintenance	85	2.87e-03	0.187000	7.34e-03
Metabolism of cofactors	19	1.60e-01	0.186000	2.35e-01
mRNA Splicing	187	1.11e-05	0.186000	5.15e-05
Innate Immune System	861	2.29e-20	-0.185000	7.88e-19
O-glycosylation of TSR domain-containing proteins	37	5.18e-02	-0.185000	9.04e-02
Neutrophil degranulation	415	1.07e-10	-0.184000	1.32e-09
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	76	5.44e-03	-0.184000	1.28e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	1.12e-01	0.184000	1.74e-01
Neurotransmitter release cycle	47	3.00e-02	-0.183000	5.59e-02
Negative regulation of FGFR4 signaling	28	9.45e-02	-0.183000	1.51e-01
NoRC negatively regulates rRNA expression	68	9.31e-03	0.182000	2.03e-02
Response of Mtb to phagocytosis	22	1.39e-01	-0.182000	2.10e-01
GABA receptor activation	48	2.92e-02	-0.182000	5.47e-02
Sema4D in semaphorin signaling	24	1.23e-01	-0.182000	1.88e-01
Activation of Matrix Metalloproteinases	26	1.09e-01	-0.181000	1.71e-01
G1/S Transition	131	3.41e-04	0.181000	1.14e-03
G alpha (s) signalling events	93	2.57e-03	-0.181000	6.66e-03
Resolution of Abasic Sites (AP sites)	38	5.39e-02	0.181000	9.36e-02
Adrenaline,noradrenaline inhibits insulin secretion	23	1.34e-01	-0.181000	2.02e-01
Assembly of the ORC complex at the origin of replication	31	8.18e-02	0.181000	1.35e-01
Estrogen-dependent gene expression	109	1.14e-03	-0.180000	3.26e-03
p75NTR signals via NF-kB	16	2.12e-01	-0.180000	3.00e-01
Acetylcholine binding and downstream events	10	3.24e-01	0.180000	4.24e-01
Postsynaptic nicotinic acetylcholine receptors	10	3.24e-01	0.180000	4.24e-01
Chromatin modifying enzymes	224	3.39e-06	-0.180000	1.81e-05
Chromatin organization	224	3.39e-06	-0.180000	1.81e-05
Termination of translesion DNA synthesis	32	7.86e-02	0.180000	1.30e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	8.85e-02	-0.180000	1.43e-01
Metabolism of amine-derived hormones	12	2.82e-01	0.179000	3.77e-01
tRNA modification in the nucleus and cytosol	43	4.28e-02	0.179000	7.62e-02
Biosynthesis of DHA-derived SPMs	14	2.48e-01	0.178000	3.43e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	8.69e-02	-0.178000	1.41e-01
Branched-chain amino acid catabolism	21	1.59e-01	-0.178000	2.34e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	1.27e-02	-0.177000	2.67e-02
Amino acid transport across the plasma membrane	31	8.76e-02	-0.177000	1.42e-01
Deubiquitination	248	1.63e-06	-0.177000	9.51e-06
mRNA Splicing - Major Pathway	179	4.61e-05	0.176000	1.84e-04
Interleukin-37 signaling	21	1.63e-01	-0.176000	2.39e-01
Neurotoxicity of clostridium toxins	10	3.36e-01	0.176000	4.34e-01
Defective B3GALTL causes PpS	36	6.83e-02	-0.176000	1.15e-01
Regulation of RUNX3 expression and activity	54	2.61e-02	0.175000	4.97e-02
G2/M Checkpoints	140	3.57e-04	0.175000	1.19e-03
Signaling by Interleukins	388	3.45e-09	-0.174000	3.55e-08
Mitochondrial tRNA aminoacylation	21	1.66e-01	-0.174000	2.43e-01
Mitotic Prophase	104	2.13e-03	-0.174000	5.66e-03
GLI3 is processed to GLI3R by the proteasome	57	2.34e-02	0.174000	4.57e-02
Transcriptional regulation of testis differentiation	11	3.19e-01	-0.174000	4.17e-01
Cholesterol biosynthesis	24	1.42e-01	-0.173000	2.12e-01
FRS-mediated FGFR2 signaling	22	1.59e-01	-0.173000	2.35e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	3.44e-01	-0.173000	4.41e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	1.61e-01	-0.173000	2.36e-01
E3 ubiquitin ligases ubiquitinate target proteins	53	2.98e-02	-0.173000	5.57e-02
Nonhomologous End-Joining (NHEJ)	43	5.04e-02	-0.172000	8.81e-02
Metabolism of polyamines	57	2.47e-02	0.172000	4.74e-02
Infection with Mycobacterium tuberculosis	24	1.45e-01	-0.172000	2.17e-01
TICAM1-dependent activation of IRF3/IRF7	12	3.05e-01	0.171000	4.01e-01
Budding and maturation of HIV virion	28	1.19e-01	-0.170000	1.82e-01
Vitamin D (calciferol) metabolism	10	3.51e-01	-0.170000	4.50e-01
tRNA Aminoacylation	42	5.82e-02	-0.169000	1.00e-01
Disease	1461	1.66e-27	-0.169000	1.22e-25
Beta-catenin independent WNT signaling	138	6.38e-04	-0.168000	1.98e-03
ZBP1(DAI) mediated induction of type I IFNs	19	2.04e-01	-0.168000	2.92e-01
Cardiac conduction	109	2.41e-03	-0.168000	6.34e-03
Response of EIF2AK1 (HRI) to heme deficiency	15	2.62e-01	0.167000	3.55e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	97	4.49e-03	-0.167000	1.08e-02
Class B/2 (Secretin family receptors)	71	1.53e-02	-0.166000	3.16e-02
RIP-mediated NFkB activation via ZBP1	16	2.51e-01	-0.166000	3.47e-01
Cytosolic tRNA aminoacylation	24	1.61e-01	-0.165000	2.36e-01
Developmental Biology	851	2.55e-16	-0.165000	6.19e-15
PD-1 signaling	18	2.29e-01	0.164000	3.21e-01
tRNA processing	124	1.64e-03	0.164000	4.49e-03
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	10	3.71e-01	-0.164000	4.69e-01
Diseases of hemostasis	10	3.71e-01	-0.164000	4.69e-01
Pentose phosphate pathway	13	3.07e-01	-0.163000	4.03e-01
Post-chaperonin tubulin folding pathway	20	2.07e-01	0.163000	2.94e-01
Defective CFTR causes cystic fibrosis	58	3.21e-02	0.163000	5.93e-02
Post-translational protein phosphorylation	87	8.83e-03	-0.162000	1.94e-02
Collagen formation	83	1.10e-02	-0.161000	2.36e-02
Negative epigenetic regulation of rRNA expression	71	1.88e-02	0.161000	3.77e-02
Transport of inorganic cations/anions and amino acids/oligopeptides	92	7.56e-03	-0.161000	1.71e-02
Unfolded Protein Response (UPR)	90	8.54e-03	-0.160000	1.88e-02
Signaling by EGFR in Cancer	25	1.66e-01	-0.160000	2.42e-01
Nuclear Envelope (NE) Reassembly	73	1.83e-02	-0.160000	3.68e-02
Nervous system development	524	3.70e-10	-0.160000	4.27e-09
Oncogene Induced Senescence	31	1.25e-01	-0.159000	1.91e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	16	2.70e-01	-0.159000	3.64e-01
Cytokine Signaling in Immune system	605	2.12e-11	-0.159000	3.05e-10
Inhibition of DNA recombination at telomere	40	8.32e-02	0.158000	1.37e-01
Voltage gated Potassium channels	33	1.16e-01	-0.158000	1.79e-01
Purine catabolism	17	2.60e-01	0.158000	3.53e-01
Defective C1GALT1C1 causes TNPS	13	3.26e-01	0.157000	4.25e-01
Regulation of TP53 Activity	155	7.20e-04	-0.157000	2.20e-03
Fc epsilon receptor (FCERI) signaling	128	2.12e-03	-0.157000	5.65e-03
Viral Messenger RNA Synthesis	44	7.15e-02	-0.157000	1.20e-01
The phototransduction cascade	27	1.59e-01	-0.156000	2.35e-01
Transcriptional regulation by RUNX3	94	8.71e-03	-0.156000	1.91e-02
Telomere C-strand synthesis initiation	13	3.29e-01	-0.156000	4.28e-01
Hedgehog ligand biogenesis	63	3.18e-02	0.156000	5.88e-02
Metabolism of RNA	677	4.23e-12	0.156000	6.87e-11
Phosphorylation of CD3 and TCR zeta chains	17	2.66e-01	0.156000	3.61e-01
Transport of small molecules	608	4.96e-11	-0.156000	6.49e-10
Removal of the Flap Intermediate from the C-strand	17	2.68e-01	-0.155000	3.62e-01
Base Excision Repair	64	3.22e-02	0.155000	5.93e-02
Diseases of metabolism	218	8.06e-05	-0.155000	3.05e-04
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	27	1.64e-01	0.155000	2.40e-01
TCF dependent signaling in response to WNT	187	2.61e-04	-0.155000	8.96e-04
Phase II - Conjugation of compounds	76	2.00e-02	0.154000	3.97e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	2.88e-01	-0.153000	3.83e-01
IRAK4 deficiency (TLR2/4)	16	2.90e-01	0.153000	3.85e-01
Heme degradation	12	3.62e-01	0.152000	4.60e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	36	1.15e-01	-0.152000	1.78e-01
rRNA modification in the nucleus and cytosol	60	4.21e-02	0.152000	7.52e-02
Plasma lipoprotein assembly	13	3.44e-01	0.152000	4.41e-01
FRS-mediated FGFR4 signaling	19	2.53e-01	-0.151000	3.48e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	26	1.83e-01	-0.151000	2.65e-01
UCH proteinases	92	1.26e-02	0.150000	2.67e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	38	1.10e-01	0.150000	1.73e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	3.87e-02	0.149000	6.95e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	3.06e-01	-0.148000	4.02e-01
FGFR2 alternative splicing	25	2.03e-01	0.147000	2.91e-01
Visual phototransduction	73	2.99e-02	-0.147000	5.58e-02
Deadenylation-dependent mRNA decay	53	6.55e-02	-0.146000	1.11e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	25	2.06e-01	-0.146000	2.94e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	3.28e-01	-0.146000	4.27e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	3.28e-01	-0.146000	4.27e-01
Scavenging by Class A Receptors	17	2.98e-01	0.146000	3.94e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	1.99e-01	0.145000	2.86e-01
Signaling by FGFR	80	2.46e-02	-0.145000	4.72e-02
Regulation of TP53 Activity through Methylation	19	2.75e-01	0.145000	3.70e-01
FGFR4 ligand binding and activation	11	4.06e-01	0.145000	5.03e-01
TNFR2 non-canonical NF-kB pathway	91	1.73e-02	0.144000	3.51e-02
Activation of kainate receptors upon glutamate binding	24	2.22e-01	-0.144000	3.11e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	2.90e-01	-0.144000	3.86e-01
Glycerophospholipid biosynthesis	116	7.46e-03	-0.144000	1.69e-02
Transcriptional regulation of pluripotent stem cells	30	1.74e-01	-0.143000	2.53e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	4.33e-01	0.143000	5.28e-01
Phenylalanine and tyrosine metabolism	10	4.33e-01	0.143000	5.28e-01
RNA Polymerase I Promoter Clearance	72	3.57e-02	0.143000	6.49e-02
RNA Polymerase I Transcription	72	3.57e-02	0.143000	6.49e-02
Formation of the beta-catenin:TCF transactivating complex	53	7.15e-02	-0.143000	1.20e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	34	1.49e-01	-0.143000	2.21e-01
Sema4D induced cell migration and growth-cone collapse	20	2.69e-01	-0.143000	3.63e-01
G alpha (i) signalling events	199	5.22e-04	-0.143000	1.67e-03
Axon guidance	502	4.28e-08	-0.143000	3.70e-07
Late Phase of HIV Life Cycle	135	4.27e-03	-0.142000	1.04e-02
Tight junction interactions	22	2.48e-01	-0.142000	3.43e-01
Regulation of TP53 Activity through Association with Co-factors	12	3.99e-01	-0.141000	4.97e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	2.53e-01	-0.141000	3.48e-01
IRF3-mediated induction of type I IFN	12	4.00e-01	-0.140000	4.97e-01
HCMV Late Events	78	3.23e-02	-0.140000	5.95e-02
Programmed Cell Death	195	7.38e-04	-0.140000	2.25e-03
Regulation of FZD by ubiquitination	21	2.68e-01	-0.140000	3.63e-01
The canonical retinoid cycle in rods (twilight vision)	18	3.06e-01	0.139000	4.02e-01
SHC-mediated cascade:FGFR2	20	2.81e-01	-0.139000	3.76e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.84e-01	-0.139000	4.84e-01
Synthesis, secretion, and deacylation of Ghrelin	13	3.88e-01	0.138000	4.86e-01
Metabolism of proteins	1745	4.58e-22	-0.138000	2.26e-20
Synthesis of bile acids and bile salts	30	1.93e-01	-0.137000	2.77e-01
Metabolism of non-coding RNA	53	8.38e-02	-0.137000	1.37e-01
snRNP Assembly	53	8.38e-02	-0.137000	1.37e-01
Regulation of RUNX2 expression and activity	70	4.71e-02	0.137000	8.28e-02
IL-6-type cytokine receptor ligand interactions	16	3.43e-01	-0.137000	4.41e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	3.20e-01	-0.135000	4.18e-01
HIV Life Cycle	147	4.65e-03	-0.135000	1.11e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	64	6.18e-02	0.135000	1.06e-01
Cleavage of the damaged purine	29	2.10e-01	0.135000	2.97e-01
Depurination	29	2.10e-01	0.135000	2.97e-01
Recognition and association of DNA glycosylase with site containing an affected purine	29	2.10e-01	0.135000	2.97e-01
Pyruvate metabolism	28	2.18e-01	-0.134000	3.07e-01
Dual incision in TC-NER	65	6.25e-02	0.134000	1.07e-01
RNA Polymerase I Transcription Termination	30	2.06e-01	0.133000	2.94e-01
Interferon Signaling	174	2.49e-03	-0.133000	6.49e-03
Peroxisomal lipid metabolism	27	2.32e-01	-0.133000	3.25e-01
Mitotic G1 phase and G1/S transition	147	5.67e-03	0.132000	1.32e-02
Activation of SMO	18	3.35e-01	-0.131000	4.34e-01
Inactivation, recovery and regulation of the phototransduction cascade	26	2.47e-01	-0.131000	3.42e-01
S Phase	160	4.57e-03	0.130000	1.09e-02
cGMP effects	14	4.02e-01	-0.129000	4.99e-01
Pre-NOTCH Expression and Processing	71	5.93e-02	-0.129000	1.02e-01
Presynaptic depolarization and calcium channel opening	11	4.58e-01	0.129000	5.52e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	3.57e-01	-0.129000	4.55e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	3.57e-01	-0.129000	4.55e-01
Processing of Intronless Pre-mRNAs	19	3.30e-01	-0.129000	4.28e-01
Cytosolic sensors of pathogen-associated DNA	61	8.24e-02	-0.129000	1.36e-01
Hyaluronan metabolism	14	4.05e-01	-0.128000	5.02e-01
Assembly of collagen fibrils and other multimeric structures	52	1.10e-01	-0.128000	1.72e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	105	2.35e-02	0.128000	4.57e-02
Apoptosis	169	4.13e-03	-0.128000	1.01e-02
Signaling by FGFR2 IIIa TM	19	3.35e-01	0.128000	4.34e-01
Regulation of HMOX1 expression and activity	63	8.05e-02	0.127000	1.33e-01
Gluconeogenesis	29	2.36e-01	-0.127000	3.29e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	4.12e-01	-0.127000	5.09e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	3.97e-01	-0.126000	4.96e-01
Caspase activation via Death Receptors in the presence of ligand	15	4.00e-01	-0.125000	4.98e-01
ABC transporter disorders	73	6.45e-02	0.125000	1.09e-01
Cyclin D associated events in G1	45	1.47e-01	-0.125000	2.19e-01
G1 Phase	45	1.47e-01	-0.125000	2.19e-01
Dual Incision in GG-NER	41	1.67e-01	0.125000	2.44e-01
Muscle contraction	164	5.87e-03	-0.125000	1.36e-02
Base-Excision Repair, AP Site Formation	36	1.98e-01	0.124000	2.84e-01
PIWI-interacting RNA (piRNA) biogenesis	25	2.83e-01	0.124000	3.78e-01
Triglyceride metabolism	28	2.58e-01	-0.123000	3.53e-01
Arachidonic acid metabolism	44	1.58e-01	0.123000	2.34e-01
Generic Transcription Pathway	1126	2.84e-12	-0.123000	4.82e-11
Recognition of DNA damage by PCNA-containing replication complex	30	2.44e-01	0.123000	3.39e-01
Chaperonin-mediated protein folding	83	5.34e-02	-0.123000	9.30e-02
Ion channel transport	152	9.72e-03	-0.121000	2.11e-02
Neddylation	222	1.83e-03	-0.121000	4.93e-03
Cyclin E associated events during G1/S transition	83	5.73e-02	0.121000	9.91e-02
Asymmetric localization of PCP proteins	62	1.01e-01	0.121000	1.60e-01
Common Pathway of Fibrin Clot Formation	15	4.23e-01	-0.120000	5.19e-01
Regulation of gene expression in beta cells	14	4.38e-01	-0.120000	5.32e-01
TNF signaling	44	1.71e-01	-0.119000	2.49e-01
ER-Phagosome pathway	87	5.45e-02	0.119000	9.45e-02
Gene expression (Transcription)	1379	8.57e-14	-0.119000	1.74e-12
Biosynthesis of specialized proresolving mediators (SPMs)	15	4.28e-01	0.118000	5.25e-01
Homology Directed Repair	111	3.16e-02	0.118000	5.84e-02
Nitric oxide stimulates guanylate cyclase	18	3.87e-01	-0.118000	4.86e-01
PTEN Regulation	140	1.69e-02	-0.117000	3.44e-02
Extension of Telomeres	51	1.50e-01	0.117000	2.22e-01
Sensory Perception	181	7.27e-03	-0.116000	1.66e-02
DNA Damage Recognition in GG-NER	38	2.18e-01	0.115000	3.07e-01
Ub-specific processing proteases	177	8.15e-03	-0.115000	1.81e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	4.42e-01	-0.115000	5.35e-01
Synthesis of PC	27	3.04e-01	-0.114000	4.01e-01
Processing of Capped Intron-Containing Pre-mRNA	238	2.42e-03	0.114000	6.35e-03
RNA Pol II CTD phosphorylation and interaction with CE	27	3.07e-01	0.114000	4.02e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	3.07e-01	0.114000	4.02e-01
Signaling by the B Cell Receptor (BCR)	106	4.32e-02	-0.114000	7.67e-02
FGFR2 mutant receptor activation	30	2.82e-01	0.113000	3.77e-01
Metabolism of Angiotensinogen to Angiotensins	13	4.79e-01	-0.113000	5.75e-01
E2F mediated regulation of DNA replication	22	3.60e-01	0.113000	4.59e-01
Dopamine Neurotransmitter Release Cycle	22	3.60e-01	-0.113000	4.59e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	4.36e-01	0.113000	5.31e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	20	3.85e-01	-0.112000	4.84e-01
Cell Cycle Checkpoints	260	1.94e-03	0.112000	5.20e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	2.47e-01	0.111000	3.42e-01
Signaling by NOTCH	194	7.72e-03	-0.111000	1.74e-02
TP53 Regulates Transcription of Death Receptors and Ligands	11	5.27e-01	-0.110000	6.15e-01
RNA Polymerase II Transcription	1244	5.24e-11	-0.110000	6.80e-10
Surfactant metabolism	20	3.96e-01	-0.110000	4.96e-01
ATF6 (ATF6-alpha) activates chaperones	12	5.11e-01	-0.110000	6.01e-01
SHC-mediated cascade:FGFR4	17	4.37e-01	-0.109000	5.31e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	4.39e-01	0.109000	5.32e-01
Cyclin A:Cdk2-associated events at S phase entry	85	8.49e-02	0.108000	1.38e-01
Diseases associated with O-glycosylation of proteins	62	1.42e-01	-0.108000	2.13e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	1.01e-01	0.107000	1.60e-01
Prefoldin mediated transfer of substrate to CCT/TriC	27	3.35e-01	0.107000	4.34e-01
Defective Intrinsic Pathway for Apoptosis	22	3.86e-01	-0.107000	4.85e-01
Apoptosis induced DNA fragmentation	12	5.23e-01	0.107000	6.11e-01
Tryptophan catabolism	13	5.07e-01	0.106000	5.99e-01
Homologous DNA Pairing and Strand Exchange	42	2.33e-01	0.106000	3.26e-01
Infectious disease	740	8.00e-07	-0.106000	5.10e-06
Diseases of programmed cell death	62	1.48e-01	0.106000	2.21e-01
Activation of NF-kappaB in B cells	65	1.41e-01	0.106000	2.11e-01
Packaging Of Telomere Ends	25	3.61e-01	0.105000	4.60e-01
Biological oxidations	157	2.26e-02	0.105000	4.44e-02
Stimuli-sensing channels	84	9.56e-02	-0.105000	1.53e-01
RHO GTPases Activate Formins	118	4.96e-02	-0.105000	8.68e-02
Metabolism of vitamins and cofactors	171	1.86e-02	-0.104000	3.73e-02
Formation of apoptosome	11	5.50e-01	-0.104000	6.37e-01
Regulation of the apoptosome activity	11	5.50e-01	-0.104000	6.37e-01
Smooth Muscle Contraction	34	2.94e-01	-0.104000	3.90e-01
Downregulation of ERBB2:ERBB3 signaling	13	5.17e-01	-0.104000	6.07e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	11	5.52e-01	0.103000	6.39e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	15	4.88e-01	-0.103000	5.83e-01
Phospholipase C-mediated cascade; FGFR3	11	5.56e-01	0.103000	6.41e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	29	3.39e-01	-0.103000	4.38e-01
Cleavage of the damaged pyrimidine	34	3.05e-01	0.102000	4.01e-01
Depyrimidination	34	3.05e-01	0.102000	4.01e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	34	3.05e-01	0.102000	4.01e-01
Glutamate Neurotransmitter Release Cycle	23	4.00e-01	-0.101000	4.97e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	1.02e-01	0.101000	1.61e-01
Hedgehog ‘on’ state	84	1.11e-01	0.100000	1.74e-01
Pyroptosis	24	3.98e-01	-0.099700	4.97e-01
G beta:gamma signalling through BTK	14	5.19e-01	-0.099500	6.08e-01
Regulated Necrosis	51	2.21e-01	-0.099100	3.10e-01
Cellular response to chemical stress	150	3.65e-02	0.098900	6.60e-02
Mitochondrial calcium ion transport	22	4.22e-01	-0.098900	5.19e-01
RIPK1-mediated regulated necrosis	27	3.76e-01	-0.098500	4.74e-01
Regulation of necroptotic cell death	27	3.76e-01	-0.098500	4.74e-01
Phospholipase C-mediated cascade; FGFR2	15	5.09e-01	0.098400	6.00e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	2.39e-01	-0.098200	3.32e-01
B-WICH complex positively regulates rRNA expression	53	2.17e-01	0.097900	3.07e-01
Aggrephagy	21	4.37e-01	0.097900	5.31e-01
Formation of tubulin folding intermediates by CCT/TriC	23	4.24e-01	-0.096400	5.20e-01
Fertilization	16	5.05e-01	0.096400	5.97e-01
FGFR2 ligand binding and activation	15	5.21e-01	0.095700	6.10e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	12	5.67e-01	0.095400	6.52e-01
RHO GTPases activate PKNs	53	2.30e-01	-0.095300	3.22e-01
Formation of the Early Elongation Complex	33	3.44e-01	0.095200	4.41e-01
Formation of the HIV-1 Early Elongation Complex	33	3.44e-01	0.095200	4.41e-01
Dectin-2 family	18	4.85e-01	0.095100	5.80e-01
HIV Transcription Initiation	47	2.59e-01	0.095100	3.53e-01
RNA Polymerase II HIV Promoter Escape	47	2.59e-01	0.095100	3.53e-01
RNA Polymerase II Promoter Escape	47	2.59e-01	0.095100	3.53e-01
RNA Polymerase II Transcription Initiation	47	2.59e-01	0.095100	3.53e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	47	2.59e-01	0.095100	3.53e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	47	2.59e-01	0.095100	3.53e-01
Separation of Sister Chromatids	168	3.51e-02	0.094200	6.41e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	1.36e-01	0.094000	2.05e-01
Mitochondrial biogenesis	91	1.21e-01	-0.093900	1.86e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	5.09e-01	0.092600	6.00e-01
GABA synthesis, release, reuptake and degradation	18	4.97e-01	-0.092500	5.91e-01
Senescence-Associated Secretory Phenotype (SASP)	72	1.77e-01	0.092000	2.57e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	30	3.83e-01	0.092000	4.83e-01
Collagen biosynthesis and modifying enzymes	61	2.14e-01	-0.091900	3.03e-01
Pre-NOTCH Transcription and Translation	55	2.40e-01	-0.091500	3.34e-01
Inactivation of CSF3 (G-CSF) signaling	25	4.29e-01	-0.091400	5.25e-01
RNA polymerase II transcribes snRNA genes	71	1.84e-01	-0.091200	2.65e-01
Telomere C-strand (Lagging Strand) Synthesis	34	3.62e-01	0.090300	4.60e-01
TRAF6 mediated NF-kB activation	23	4.55e-01	-0.090000	5.50e-01
Maturation of nucleoprotein	11	6.06e-01	-0.089800	6.86e-01
Metabolism of porphyrins	23	4.57e-01	0.089700	5.51e-01
Translesion Synthesis by POLH	18	5.11e-01	0.089500	6.01e-01
Alpha-protein kinase 1 signaling pathway	11	6.07e-01	-0.089500	6.87e-01
Metabolism of water-soluble vitamins and cofactors	117	9.51e-02	-0.089300	1.52e-01
Transcription of E2F targets under negative control by DREAM complex	19	5.02e-01	0.089000	5.95e-01
Signaling by FGFR2	67	2.07e-01	-0.089000	2.95e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	6.11e-01	0.088600	6.89e-01
ROS and RNS production in phagocytes	32	3.86e-01	0.088500	4.85e-01
Complement cascade	37	3.52e-01	0.088400	4.50e-01
Presynaptic phase of homologous DNA pairing and strand exchange	39	3.41e-01	0.088100	4.40e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	2.54e-01	-0.088000	3.49e-01
Cytosolic sulfonation of small molecules	21	4.88e-01	-0.087500	5.82e-01
Formation of TC-NER Pre-Incision Complex	53	2.73e-01	0.087000	3.67e-01
HIV Infection	223	2.58e-02	-0.086600	4.92e-02
Late endosomal microautophagy	30	4.12e-01	-0.086400	5.09e-01
Initiation of Nuclear Envelope (NE) Reformation	19	5.18e-01	-0.085700	6.07e-01
Cellular Senescence	153	6.85e-02	-0.085300	1.15e-01
Transcriptional regulation of granulopoiesis	52	2.93e-01	-0.084300	3.89e-01
Nucleotide Excision Repair	110	1.27e-01	0.084200	1.93e-01
Interconversion of nucleotide di- and triphosphates	29	4.32e-01	0.084200	5.28e-01
Potassium Channels	83	1.86e-01	-0.084000	2.67e-01
Acyl chain remodelling of PI	13	6.05e-01	-0.083000	6.86e-01
Negative regulation of FLT3	14	5.93e-01	-0.082600	6.76e-01
NGF-stimulated transcription	40	3.69e-01	-0.082100	4.68e-01
Processing of DNA double-strand break ends	72	2.29e-01	0.082000	3.21e-01
Intraflagellar transport	39	3.77e-01	0.081800	4.75e-01
G0 and Early G1	27	4.63e-01	0.081700	5.56e-01
IKK complex recruitment mediated by RIP1	22	5.08e-01	-0.081500	6.00e-01
G beta:gamma signalling through PLC beta	15	5.85e-01	-0.081400	6.69e-01
Presynaptic function of Kainate receptors	15	5.85e-01	-0.081400	6.69e-01
Regulation of Complement cascade	29	4.51e-01	0.080900	5.45e-01
Aspartate and asparagine metabolism	10	6.59e-01	0.080500	7.33e-01
Cytoprotection by HMOX1	120	1.29e-01	0.080300	1.95e-01
TRP channels	18	5.56e-01	-0.080200	6.41e-01
Formation of RNA Pol II elongation complex	57	2.96e-01	-0.080000	3.92e-01
RNA Polymerase II Transcription Elongation	57	2.96e-01	-0.080000	3.92e-01
Plasma lipoprotein clearance	29	4.58e-01	-0.079700	5.52e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	24	5.03e-01	0.079000	5.95e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	24	5.03e-01	0.079000	5.95e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	24	5.03e-01	0.079000	5.95e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	24	5.03e-01	0.079000	5.95e-01
Diseases of DNA Double-Strand Break Repair	24	5.03e-01	0.079000	5.95e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	51	3.29e-01	-0.079000	4.28e-01
Antigen processing-Cross presentation	98	1.78e-01	0.078700	2.58e-01
Downregulation of ERBB2 signaling	28	4.72e-01	-0.078600	5.67e-01
RA biosynthesis pathway	17	5.78e-01	0.077900	6.64e-01
Interleukin-12 family signaling	51	3.40e-01	-0.077200	4.39e-01
Diseases of mitotic cell cycle	38	4.24e-01	0.074900	5.20e-01
NF-kB is activated and signals survival	13	6.40e-01	-0.074800	7.17e-01
Cellular hexose transport	17	5.94e-01	0.074700	6.77e-01
Termination of O-glycan biosynthesis	19	5.74e-01	-0.074500	6.60e-01
Gene Silencing by RNA	97	2.06e-01	-0.074300	2.94e-01
Killing mechanisms	11	6.70e-01	-0.074100	7.41e-01
WNT5:FZD7-mediated leishmania damping	11	6.70e-01	-0.074100	7.41e-01
Regulation of RAS by GAPs	64	3.05e-01	0.074100	4.01e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	5.22e-01	-0.073900	6.11e-01
Transcriptional Regulation by TP53	356	1.74e-02	-0.073300	3.51e-02
Acetylcholine Neurotransmitter Release Cycle	15	6.23e-01	-0.073300	7.01e-01
Collagen chain trimerization	39	4.29e-01	-0.073200	5.25e-01
Butyrophilin (BTN) family interactions	10	6.91e-01	0.072700	7.60e-01
Apoptotic factor-mediated response	19	5.88e-01	-0.071800	6.72e-01
Striated Muscle Contraction	27	5.20e-01	0.071500	6.09e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	6.98e-01	-0.070800	7.64e-01
p75NTR recruits signalling complexes	13	6.61e-01	-0.070300	7.33e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	6.16e-01	0.070300	6.94e-01
RNA Polymerase II Pre-transcription Events	80	2.78e-01	-0.070100	3.73e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	20	5.89e-01	-0.069800	6.73e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	4.59e-01	0.069400	5.53e-01
C-type lectin receptors (CLRs)	128	1.76e-01	-0.069300	2.55e-01
Mitotic G2-G2/M phases	183	1.12e-01	0.068100	1.74e-01
Advanced glycosylation endproduct receptor signaling	11	6.96e-01	-0.068100	7.63e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	5.42e-01	-0.067800	6.30e-01
NCAM1 interactions	35	4.88e-01	-0.067700	5.82e-01
Norepinephrine Neurotransmitter Release Cycle	16	6.40e-01	-0.067500	7.17e-01
Transcriptional regulation by RUNX1	187	1.12e-01	-0.067300	1.75e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	5.81e-01	0.066500	6.66e-01
HDR through Single Strand Annealing (SSA)	37	4.85e-01	0.066300	5.80e-01
Mismatch Repair	15	6.57e-01	-0.066200	7.32e-01
Glycogen storage diseases	14	6.69e-01	0.066000	7.41e-01
mRNA Capping	29	5.39e-01	0.065900	6.27e-01
ERBB2 Activates PTK6 Signaling	12	6.93e-01	-0.065800	7.62e-01
Protein folding	89	2.85e-01	-0.065500	3.80e-01
G2/M Transition	181	1.28e-01	0.065500	1.95e-01
Acyl chain remodelling of PC	22	5.95e-01	0.065400	6.78e-01
MASTL Facilitates Mitotic Progression	10	7.20e-01	0.065400	7.82e-01
Organelle biogenesis and maintenance	272	6.94e-02	-0.063900	1.17e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	6.40e-01	-0.063700	7.17e-01
TNFs bind their physiological receptors	21	6.17e-01	0.063100	6.95e-01
GPCR ligand binding	273	7.36e-02	-0.062800	1.23e-01
Prostacyclin signalling through prostacyclin receptor	15	6.74e-01	-0.062700	7.44e-01
Acyl chain remodelling of PE	23	6.04e-01	0.062400	6.86e-01
DNA Double Strand Break Response	52	4.37e-01	-0.062300	5.31e-01
Interferon gamma signaling	80	3.37e-01	-0.062100	4.35e-01
HATs acetylate histones	101	2.83e-01	-0.061800	3.78e-01
Serotonin Neurotransmitter Release Cycle	17	6.60e-01	-0.061600	7.33e-01
Nucleotide catabolism	31	5.54e-01	0.061400	6.40e-01
TP53 Regulates Transcription of Cell Death Genes	43	4.93e-01	-0.060500	5.87e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	34	5.44e-01	0.060200	6.31e-01
Na+/Cl- dependent neurotransmitter transporters	13	7.13e-01	-0.059000	7.75e-01
Disorders of transmembrane transporters	157	2.05e-01	-0.058600	2.92e-01
tRNA processing in the nucleus	59	4.36e-01	-0.058600	5.31e-01
Signaling by NOTCH4	81	3.64e-01	0.058300	4.63e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	15	6.98e-01	0.057900	7.64e-01
Fatty acid metabolism	153	2.18e-01	-0.057700	3.07e-01
RNA Polymerase I Transcription Initiation	47	4.97e-01	0.057300	5.91e-01
HDR through MMEJ (alt-NHEJ)	10	7.54e-01	-0.057200	8.10e-01
ABC-family proteins mediated transport	97	3.32e-01	0.057000	4.31e-01
Recycling of bile acids and salts	13	7.22e-01	0.056900	7.84e-01
Activation of HOX genes during differentiation	82	3.74e-01	-0.056800	4.73e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	82	3.74e-01	-0.056800	4.73e-01
Glyoxylate metabolism and glycine degradation	25	6.24e-01	-0.056600	7.02e-01
Processing of Capped Intronless Pre-mRNA	28	6.05e-01	0.056400	6.86e-01
Regulation of PTEN stability and activity	67	4.27e-01	0.056100	5.24e-01
Mitophagy	28	6.08e-01	-0.055900	6.87e-01
Positive epigenetic regulation of rRNA expression	68	4.30e-01	0.055400	5.25e-01
Diseases of DNA repair	34	5.83e-01	0.054500	6.68e-01
Phase 2 - plateau phase	14	7.28e-01	0.053700	7.89e-01
Incretin synthesis, secretion, and inactivation	18	6.94e-01	-0.053600	7.62e-01
Chaperone Mediated Autophagy	18	6.96e-01	-0.053300	7.63e-01
MAPK6/MAPK4 signaling	87	3.97e-01	-0.052600	4.96e-01
DNA Damage/Telomere Stress Induced Senescence	52	5.16e-01	-0.052100	6.06e-01
Binding and Uptake of Ligands by Scavenger Receptors	33	6.05e-01	0.052100	6.86e-01
Trafficking and processing of endosomal TLR	11	7.66e-01	-0.051900	8.18e-01
Bile acid and bile salt metabolism	37	5.85e-01	-0.051800	6.69e-01
Plasma lipoprotein remodeling	23	6.69e-01	-0.051400	7.41e-01
Degradation of beta-catenin by the destruction complex	83	4.18e-01	-0.051400	5.16e-01
Mitotic Spindle Checkpoint	109	3.56e-01	0.051100	4.55e-01
Downstream TCR signaling	90	4.07e-01	0.050500	5.04e-01
ABC transporters in lipid homeostasis	15	7.37e-01	0.050100	7.97e-01
CLEC7A (Dectin-1) signaling	97	4.05e-01	-0.048900	5.02e-01
Hedgehog ‘off’ state	95	4.14e-01	0.048500	5.11e-01
Metabolic disorders of biological oxidation enzymes	30	6.46e-01	0.048400	7.21e-01
Cilium Assembly	181	2.62e-01	-0.048300	3.55e-01
Cellular response to hypoxia	73	4.78e-01	0.048000	5.74e-01
Interferon alpha/beta signaling	57	5.33e-01	0.047700	6.21e-01
Formation of Fibrin Clot (Clotting Cascade)	27	6.68e-01	-0.047700	7.41e-01
Amyloid fiber formation	60	5.25e-01	0.047400	6.12e-01
Inwardly rectifying K+ channels	29	6.60e-01	0.047300	7.33e-01
LGI-ADAM interactions	12	7.77e-01	-0.047200	8.28e-01
Diseases associated with N-glycosylation of proteins	17	7.38e-01	-0.046900	7.97e-01
Xenobiotics	15	7.53e-01	-0.046800	8.10e-01
Activated point mutants of FGFR2	14	7.62e-01	0.046800	8.16e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	6.88e-01	0.046300	7.58e-01
Insulin receptor recycling	24	6.96e-01	0.046100	7.63e-01
Signaling by Retinoic Acid	37	6.31e-01	-0.045600	7.10e-01
FGFR2c ligand binding and activation	10	8.03e-01	0.045500	8.48e-01
PCP/CE pathway	90	4.59e-01	-0.045100	5.53e-01
RNA Polymerase III Chain Elongation	18	7.41e-01	0.045000	7.99e-01
TP53 Regulates Metabolic Genes	85	4.80e-01	-0.044300	5.75e-01
Processive synthesis on the C-strand of the telomere	19	7.39e-01	-0.044200	7.98e-01
Activation of G protein gated Potassium channels	24	7.11e-01	0.043700	7.74e-01
G protein gated Potassium channels	24	7.11e-01	0.043700	7.74e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	24	7.11e-01	0.043700	7.74e-01
Membrane binding and targetting of GAG proteins	14	7.80e-01	-0.043000	8.30e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	7.80e-01	-0.043000	8.30e-01
Signaling by FGFR2 in disease	40	6.39e-01	-0.042900	7.17e-01
Post-translational modification: synthesis of GPI-anchored proteins	64	5.57e-01	-0.042400	6.42e-01
FCERI mediated NF-kB activation	76	5.38e-01	0.040900	6.26e-01
Cytochrome P450 - arranged by substrate type	46	6.34e-01	-0.040600	7.12e-01
Glucagon-type ligand receptors	23	7.42e-01	-0.039700	8.00e-01
Phase I - Functionalization of compounds	76	5.53e-01	0.039400	6.39e-01
Carboxyterminal post-translational modifications of tubulin	37	6.79e-01	-0.039300	7.49e-01
Diseases of carbohydrate metabolism	30	7.13e-01	-0.038800	7.75e-01
Lysine catabolism	12	8.17e-01	-0.038700	8.58e-01
Intrinsic Pathway of Fibrin Clot Formation	16	7.89e-01	-0.038600	8.37e-01
Regulation of BACH1 activity	11	8.25e-01	0.038600	8.65e-01
Suppression of phagosomal maturation	13	8.11e-01	0.038300	8.53e-01
Assembly Of The HIV Virion	16	7.93e-01	-0.037900	8.40e-01
SUMOylation of DNA methylation proteins	16	7.94e-01	0.037700	8.40e-01
Transcriptional Regulation by E2F6	34	7.05e-01	-0.037500	7.70e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	7.96e-01	0.037400	8.41e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	8.39e-01	0.037100	8.78e-01
FGFR3 ligand binding and activation	11	8.32e-01	-0.037000	8.71e-01
FGFR3c ligand binding and activation	11	8.32e-01	-0.037000	8.71e-01
Amino acids regulate mTORC1	51	6.49e-01	-0.036900	7.23e-01
Resolution of Sister Chromatid Cohesion	105	5.14e-01	-0.036900	6.04e-01
Olfactory Signaling Pathway	24	7.55e-01	0.036700	8.11e-01
Regulation of TP53 Activity through Phosphorylation	91	5.45e-01	-0.036700	6.32e-01
Epigenetic regulation of gene expression	110	5.07e-01	0.036600	5.99e-01
Metabolism	1881	8.46e-03	-0.036400	1.87e-02
Polymerase switching on the C-strand of the telomere	26	7.49e-01	0.036200	8.07e-01
Host Interactions of HIV factors	125	4.86e-01	-0.036100	5.81e-01
Nicotinamide salvaging	18	7.91e-01	-0.036100	8.39e-01
Regulation of innate immune responses to cytosolic DNA	14	8.16e-01	0.035800	8.58e-01
Peptide ligand-binding receptors	106	5.24e-01	0.035800	6.12e-01
FGFR1 ligand binding and activation	13	8.24e-01	-0.035700	8.65e-01
Beta-oxidation of very long chain fatty acids	10	8.46e-01	0.035600	8.83e-01
Metabolism of folate and pterines	16	8.06e-01	-0.035500	8.50e-01
Reproduction	92	5.60e-01	0.035100	6.45e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	6.06e-01	0.035100	6.86e-01
RNA Polymerase III Abortive And Retractive Initiation	41	7.04e-01	-0.034300	7.70e-01
RNA Polymerase III Transcription	41	7.04e-01	-0.034300	7.70e-01
EML4 and NUDC in mitotic spindle formation	96	5.64e-01	-0.034000	6.50e-01
Metabolism of steroid hormones	30	7.50e-01	-0.033600	8.08e-01
Regulation of TNFR1 signaling	35	7.31e-01	-0.033600	7.92e-01
Class A/1 (Rhodopsin-like receptors)	187	4.41e-01	-0.032700	5.34e-01
Transcription of the HIV genome	69	6.49e-01	-0.031700	7.23e-01
Mitotic Metaphase and Anaphase	229	4.12e-01	0.031500	5.09e-01
Telomere Extension By Telomerase	23	7.94e-01	-0.031500	8.40e-01
Defects in cobalamin (B12) metabolism	13	8.45e-01	-0.031300	8.82e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	8.47e-01	-0.031000	8.83e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	7.77e-01	-0.030900	8.28e-01
Mitotic Anaphase	228	4.21e-01	0.030900	5.18e-01
FGFR3 mutant receptor activation	10	8.66e-01	0.030800	8.95e-01
Signaling by activated point mutants of FGFR3	10	8.66e-01	0.030800	8.95e-01
Folding of actin by CCT/TriC	10	8.71e-01	-0.029800	8.97e-01
Oxidative Stress Induced Senescence	83	6.43e-01	-0.029400	7.20e-01
SUMOylation of immune response proteins	11	8.66e-01	-0.029300	8.95e-01
Iron uptake and transport	56	7.08e-01	-0.028900	7.73e-01
Heme biosynthesis	13	8.57e-01	0.028900	8.91e-01
DNA Repair	298	4.02e-01	0.028200	4.99e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	8.33e-01	-0.028000	8.72e-01
PINK1-PRKN Mediated Mitophagy	21	8.25e-01	0.027900	8.65e-01
Downstream signaling events of B Cell Receptor (BCR)	79	6.73e-01	0.027500	7.44e-01
Interleukin-1 family signaling	126	5.96e-01	-0.027300	6.78e-01
Early Phase of HIV Life Cycle	13	8.65e-01	0.027200	8.95e-01
Acyl chain remodelling of PG	13	8.66e-01	-0.027000	8.95e-01
Transport of Mature Transcript to Cytoplasm	81	6.83e-01	0.026200	7.53e-01
Generation of second messenger molecules	29	8.07e-01	0.026100	8.51e-01
Interleukin-12 signaling	43	7.68e-01	-0.026000	8.20e-01
RMTs methylate histone arginines	44	7.65e-01	0.026000	8.18e-01
Signaling by Hedgehog	132	6.08e-01	-0.025800	6.87e-01
DNA Double-Strand Break Repair	140	5.98e-01	0.025800	6.80e-01
Phospholipase C-mediated cascade: FGFR1	14	8.69e-01	0.025400	8.97e-01
Transcriptional regulation by small RNAs	69	7.19e-01	-0.025000	7.81e-01
Transcriptional regulation by RUNX2	116	6.46e-01	-0.024700	7.21e-01
Anchoring of the basal body to the plasma membrane	97	6.74e-01	0.024700	7.44e-01
Protein localization	158	5.95e-01	0.024500	6.78e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	7.85e-01	0.024300	8.33e-01
HIV Transcription Elongation	42	7.85e-01	0.024300	8.33e-01
Tat-mediated elongation of the HIV-1 transcript	42	7.85e-01	0.024300	8.33e-01
NRIF signals cell death from the nucleus	16	8.70e-01	0.023700	8.97e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	57	7.62e-01	-0.023200	8.16e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	8.81e-01	-0.023100	9.08e-01
Meiosis	76	7.38e-01	0.022200	7.97e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	9.04e-01	0.022100	9.26e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	81	7.32e-01	-0.022000	7.92e-01
Cell Cycle, Mitotic	513	3.96e-01	0.021800	4.96e-01
Cell Cycle	637	3.52e-01	0.021600	4.50e-01
Other interleukin signaling	22	8.65e-01	-0.020900	8.95e-01
AURKA Activation by TPX2	72	7.65e-01	0.020400	8.18e-01
G2/M DNA damage checkpoint	69	7.70e-01	0.020400	8.21e-01
Meiotic synapsis	50	8.04e-01	-0.020300	8.49e-01
Centrosome maturation	81	7.59e-01	0.019800	8.14e-01
Recruitment of mitotic centrosome proteins and complexes	81	7.59e-01	0.019800	8.14e-01
Pausing and recovery of Tat-mediated HIV elongation	30	8.58e-01	0.018900	8.91e-01
Tat-mediated HIV elongation arrest and recovery	30	8.58e-01	0.018900	8.91e-01
Synthesis of PE	13	9.11e-01	0.017800	9.32e-01
RNA Polymerase III Transcription Initiation	36	8.60e-01	-0.017000	8.93e-01
Eicosanoid ligand-binding receptors	12	9.21e-01	-0.016600	9.40e-01
Vitamin B5 (pantothenate) metabolism	17	9.08e-01	0.016200	9.29e-01
Triglyceride biosynthesis	10	9.31e-01	0.015700	9.49e-01
Transferrin endocytosis and recycling	30	8.82e-01	0.015600	9.08e-01
HDACs deacetylate histones	54	8.43e-01	0.015500	8.82e-01
Metabolism of nucleotides	90	8.07e-01	0.014900	8.50e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	8.65e-01	0.014800	8.95e-01
Interleukin-10 signaling	33	8.88e-01	-0.014200	9.12e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	9.04e-01	-0.013200	9.26e-01
Formation of Incision Complex in GG-NER	43	8.82e-01	-0.013000	9.08e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	9.34e-01	-0.012800	9.51e-01
Nucleotide salvage	21	9.26e-01	0.011700	9.45e-01
Cellular responses to stress	677	6.45e-01	-0.010400	7.21e-01
TP53 Regulates Transcription of DNA Repair Genes	61	8.91e-01	0.010100	9.15e-01
TCR signaling	110	8.55e-01	-0.010100	8.91e-01
Nicotinate metabolism	29	9.27e-01	-0.009790	9.46e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	14	9.58e-01	-0.008170	9.70e-01
Interleukin-1 signaling	96	8.94e-01	-0.007870	9.17e-01
Mitotic Prometaphase	186	8.56e-01	-0.007690	8.91e-01
Regulation of PLK1 Activity at G2/M Transition	87	9.12e-01	-0.006820	9.33e-01
Hyaluronan uptake and degradation	10	9.71e-01	0.006590	9.82e-01
MicroRNA (miRNA) biogenesis	24	9.57e-01	0.006350	9.70e-01
Diseases associated with the TLR signaling cascade	28	9.55e-01	0.006170	9.69e-01
Diseases of Immune System	28	9.55e-01	0.006170	9.69e-01
HIV elongation arrest and recovery	32	9.52e-01	0.006160	9.67e-01
Pausing and recovery of HIV elongation	32	9.52e-01	0.006160	9.67e-01
M Phase	371	8.65e-01	0.005140	8.95e-01
Phase 0 - rapid depolarisation	29	9.64e-01	0.004900	9.75e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	92	9.41e-01	-0.004450	9.57e-01
Amplification of signal from the kinetochores	92	9.41e-01	-0.004450	9.57e-01
Metalloprotease DUBs	26	9.70e-01	0.004320	9.81e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	9.83e-01	0.003460	9.89e-01
Acyl chain remodelling of PS	18	9.81e-01	-0.003310	9.87e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13	9.84e-01	-0.003180	9.89e-01
Cellular responses to stimuli	687	8.94e-01	-0.002970	9.17e-01
Transcriptional Regulation by VENTX	38	9.76e-01	-0.002800	9.84e-01
DNA Damage Bypass	47	9.74e-01	-0.002720	9.84e-01
Keratinization	47	9.77e-01	0.002400	9.85e-01
Nucleotide-like (purinergic) receptors	12	9.89e-01	-0.002400	9.93e-01
Sensory perception of taste	25	9.84e-01	0.002380	9.89e-01
Loss of Nlp from mitotic centrosomes	69	9.76e-01	0.002060	9.84e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	9.76e-01	0.002060	9.84e-01
Processing of SMDT1	15	9.95e-01	0.000943	9.98e-01
RNA Polymerase III Transcription Termination	23	9.95e-01	0.000788	9.98e-01
Pregnenolone biosynthesis	11	9.97e-01	0.000640	9.98e-01
Crosslinking of collagen fibrils	10	9.98e-01	-0.000505	9.98e-01
Recruitment of NuMA to mitotic centrosomes	80	9.96e-01	0.000343	9.98e-01
Josephin domain DUBs	10	9.99e-01	-0.000291	9.99e-01

---

Detailed Gene set reports

CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation

	134
set	CLEC7A (Dectin-1) induces NFAT activation
setSize	11
pANOVA	9.68e-07
s.dist	-0.853
p.adjustANOVA	6.07e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITPR1	-11377
ITPR3	-10980
AHCYL1	-10915
PPP3CA	-10754
ITPR2	-10484
PPP3R1	-10098
NFATC3	-9412
NFATC1	-9330
PPP3CB	-7240
CALM1	-7050
NFATC2	-6401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITPR1	-11377
ITPR3	-10980
AHCYL1	-10915
PPP3CA	-10754
ITPR2	-10484
PPP3R1	-10098
NFATC3	-9412
NFATC1	-9330
PPP3CB	-7240
CALM1	-7050
NFATC2	-6401

---

Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin

	203
set	Cohesin Loading onto Chromatin
setSize	10
pANOVA	3.04e-06
s.dist	-0.852
p.adjustANOVA	1.63e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WAPL	-10914
NIPBL	-10299
RAD21	-10290
PDS5A	-10246
STAG2	-10214
SMC1A	-9265
PDS5B	-9064
STAG1	-8365
MAU2	-8358
SMC3	-7530

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WAPL	-10914
NIPBL	-10299
RAD21	-10290
PDS5A	-10246
STAG2	-10214
SMC1A	-9265
PDS5B	-9064
STAG1	-8365
MAU2	-8358
SMC3	-7530

---

Laminin interactions

Laminin interactions

	630
set	Laminin interactions
setSize	23
pANOVA	4.4e-11
s.dist	-0.793
p.adjustANOVA	5.87e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
ITGA6	-11286
NID1	-11180
ITGAV	-11113
LAMB2	-10934
ITGA1	-10654
LAMA5	-10549
LAMA4	-10450
LAMB1	-10431
LAMA1	-10193
HSPG2	-9870
ITGA3	-9698
ITGB4	-8554
ITGA7	-7619
NID2	-7130
LAMC2	-6635
COL18A1	-6473

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
ITGA6	-11286
NID1	-11180
ITGAV	-11113
LAMB2	-10934
ITGA1	-10654
LAMA5	-10549
LAMA4	-10450
LAMB1	-10431
LAMA1	-10193
HSPG2	-9870
ITGA3	-9698
ITGB4	-8554
ITGA7	-7619
NID2	-7130
LAMC2	-6635
COL18A1	-6473
LAMA2	-4266
LAMC3	-2462
LAMA3	5212

---

S33 mutants of beta-catenin aren’t phosphorylated

S33 mutants of beta-catenin aren’t phosphorylated

	1103
set	S33 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	1.53e-07
s.dist	-0.783
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

S37 mutants of beta-catenin aren’t phosphorylated

S37 mutants of beta-catenin aren’t phosphorylated

	1104
set	S37 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	1.53e-07
s.dist	-0.783
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

S45 mutants of beta-catenin aren’t phosphorylated

S45 mutants of beta-catenin aren’t phosphorylated

	1105
set	S45 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	1.53e-07
s.dist	-0.783
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Signaling by CTNNB1 phospho-site mutants

Signaling by CTNNB1 phospho-site mutants

	1175
set	Signaling by CTNNB1 phospho-site mutants
setSize	15
pANOVA	1.53e-07
s.dist	-0.783
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Signaling by GSK3beta mutants

Signaling by GSK3beta mutants

	1202
set	Signaling by GSK3beta mutants
setSize	15
pANOVA	1.53e-07
s.dist	-0.783
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

T41 mutants of beta-catenin aren’t phosphorylated

T41 mutants of beta-catenin aren’t phosphorylated

	1293
set	T41 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	1.53e-07
s.dist	-0.783
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Signaling by Hippo

Signaling by Hippo

	1204
set	Signaling by Hippo
setSize	20
pANOVA	1.64e-09
s.dist	-0.779
p.adjustANOVA	1.78e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AMOTL1	-11249
YAP1	-11062
TJP1	-10967
WWTR1	-10838
AMOT	-10567
LATS1	-10224
TJP2	-10124
SAV1	-9569
LATS2	-9336
MOB1A	-9309
STK4	-9279
AMOTL2	-9241
MOB1B	-8267
CASP3	-8212
STK3	-7927
DVL2	-7004
YWHAB	-6645
NPHP4	-6309
WWC1	-5132
YWHAE	1543

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AMOTL1	-11249
YAP1	-11062
TJP1	-10967
WWTR1	-10838
AMOT	-10567
LATS1	-10224
TJP2	-10124
SAV1	-9569
LATS2	-9336
MOB1A	-9309
STK4	-9279
AMOTL2	-9241
MOB1B	-8267
CASP3	-8212
STK3	-7927
DVL2	-7004
YWHAB	-6645
NPHP4	-6309
WWC1	-5132
YWHAE	1543

---

Syndecan interactions

Syndecan interactions

	1268
set	Syndecan interactions
setSize	20
pANOVA	1.76e-09
s.dist	-0.777
p.adjustANOVA	1.88e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	-11388
ITGB1	-11317
ITGA2	-11315
ITGA6	-11286
ITGAV	-11113
TNC	-10940
ACTN1	-10918
SDC4	-10735
PRKCA	-10498
ITGB5	-10206
TGFB1	-8918
CASK	-8743
ITGB4	-8554
THBS1	-7620
SDC1	-7206
SDC3	-6862
SDC2	-5839
FGF2	-5306
TRAPPC4	-4762
VTN	4190

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	-11388
ITGB1	-11317
ITGA2	-11315
ITGA6	-11286
ITGAV	-11113
TNC	-10940
ACTN1	-10918
SDC4	-10735
PRKCA	-10498
ITGB5	-10206
TGFB1	-8918
CASK	-8743
ITGB4	-8554
THBS1	-7620
SDC1	-7206
SDC3	-6862
SDC2	-5839
FGF2	-5306
TRAPPC4	-4762
VTN	4190

---

MET activates RAP1 and RAC1

MET activates RAP1 and RAC1

	658
set	MET activates RAP1 and RAC1
setSize	11
pANOVA	8.89e-06
s.dist	-0.773
p.adjustANOVA	4.31e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MET	-11149
DOCK7	-10847
GRB2	-10626
CRKL	-10083
RAPGEF1	-9150
RAP1B	-9004
CRK	-8881
GAB1	-8325
RAP1A	-6474
HGF	-4279
RAC1	-3826

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MET	-11149
DOCK7	-10847
GRB2	-10626
CRKL	-10083
RAPGEF1	-9150
RAP1B	-9004
CRK	-8881
GAB1	-8325
RAP1A	-6474
HGF	-4279
RAC1	-3826

---

APC truncation mutants have impaired AXIN binding

APC truncation mutants have impaired AXIN binding

	11
set	APC truncation mutants have impaired AXIN binding
setSize	14
pANOVA	6.48e-07
s.dist	-0.768
p.adjustANOVA	4.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

AXIN missense mutants destabilize the destruction complex

AXIN missense mutants destabilize the destruction complex

	24
set	AXIN missense mutants destabilize the destruction complex
setSize	14
pANOVA	6.48e-07
s.dist	-0.768
p.adjustANOVA	4.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Signaling by AMER1 mutants

Signaling by AMER1 mutants

	1168
set	Signaling by AMER1 mutants
setSize	14
pANOVA	6.48e-07
s.dist	-0.768
p.adjustANOVA	4.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Signaling by APC mutants

Signaling by APC mutants

	1169
set	Signaling by APC mutants
setSize	14
pANOVA	6.48e-07
s.dist	-0.768
p.adjustANOVA	4.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Signaling by AXIN mutants

Signaling by AXIN mutants

	1170
set	Signaling by AXIN mutants
setSize	14
pANOVA	6.48e-07
s.dist	-0.768
p.adjustANOVA	4.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

Truncations of AMER1 destabilize the destruction complex

Truncations of AMER1 destabilize the destruction complex

	1410
set	Truncations of AMER1 destabilize the destruction complex
setSize	14
pANOVA	6.48e-07
s.dist	-0.768
p.adjustANOVA	4.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321

---

ERKs are inactivated

ERKs are inactivated

	357
set	ERKs are inactivated
setSize	13
pANOVA	1.68e-06
s.dist	-0.767
p.adjustANOVA	9.67e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP4	-11285
PPP2R5D	-11215
MAPK1	-11008
DUSP7	-10143
PPP2CB	-10130
DUSP3	-9469
MAPK3	-9373
PPP2CA	-7327
VRK3	-7235
DUSP6	-6006
PPP2R1B	-5567
PPP2R1A	-4930
MAPK7	-4670

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP4	-11285
PPP2R5D	-11215
MAPK1	-11008
DUSP7	-10143
PPP2CB	-10130
DUSP3	-9469
MAPK3	-9373
PPP2CA	-7327
VRK3	-7235
DUSP6	-6006
PPP2R1B	-5567
PPP2R1A	-4930
MAPK7	-4670

---

MET activates PTK2 signaling

MET activates PTK2 signaling

	657
set	MET activates PTK2 signaling
setSize	18
pANOVA	2.19e-08
s.dist	-0.762
p.adjustANOVA	2.01e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
MET	-11149
LAMB2	-10934
LAMA5	-10549
LAMA4	-10450
LAMB1	-10431
PTK2	-10250
LAMA1	-10193
ITGA3	-9698
SRC	-7386
LAMC2	-6635
HGF	-4279
LAMA2	-4266
LAMC3	-2462
LAMA3	5212

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
MET	-11149
LAMB2	-10934
LAMA5	-10549
LAMA4	-10450
LAMB1	-10431
PTK2	-10250
LAMA1	-10193
ITGA3	-9698
SRC	-7386
LAMC2	-6635
HGF	-4279
LAMA2	-4266
LAMC3	-2462
LAMA3	5212

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

	372
set	Establishment of Sister Chromatid Cohesion
setSize	11
pANOVA	1.5e-05
s.dist	-0.754
p.adjustANOVA	6.74e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WAPL	-10914
RAD21	-10290
PDS5A	-10246
STAG2	-10214
ESCO1	-9347
SMC1A	-9265
PDS5B	-9064
STAG1	-8365
SMC3	-7530
ESCO2	-3964
CDCA5	-597

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WAPL	-10914
RAD21	-10290
PDS5A	-10246
STAG2	-10214
ESCO1	-9347
SMC1A	-9265
PDS5B	-9064
STAG1	-8365
SMC3	-7530
ESCO2	-3964
CDCA5	-597

---

MET promotes cell motility

MET promotes cell motility

	660
set	MET promotes cell motility
setSize	29
pANOVA	5.6e-12
s.dist	-0.739
p.adjustANOVA	8.81e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
MET	-11149
LAMB2	-10934
DOCK7	-10847
GRB2	-10626
LAMA5	-10549
LAMA4	-10450
LAMB1	-10431
PTK2	-10250
LAMA1	-10193
CRKL	-10083
ITGA3	-9698
RAPGEF1	-9150
RAP1B	-9004
TNS3	-8959
CRK	-8881
GAB1	-8325

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
MET	-11149
LAMB2	-10934
DOCK7	-10847
GRB2	-10626
LAMA5	-10549
LAMA4	-10450
LAMB1	-10431
PTK2	-10250
LAMA1	-10193
CRKL	-10083
ITGA3	-9698
RAPGEF1	-9150
RAP1B	-9004
TNS3	-8959
CRK	-8881
GAB1	-8325
SRC	-7386
LAMC2	-6635
RAP1A	-6474
HGF	-4279
LAMA2	-4266
RAC1	-3826
LAMC3	-2462
TNS4	4061
LAMA3	5212

---

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

	270
set	Defective EXT1 causes exostoses 1, TRPS2 and CHDS
setSize	13
pANOVA	4.77e-06
s.dist	-0.733
p.adjustANOVA	2.44e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GPC6	-11331
AGRN	-11307
SDC4	-10735
HSPG2	-9870
EXT2	-9326
GPC4	-9044
GPC1	-8024
SDC1	-7206
SDC3	-6862
EXT1	-6377
SDC2	-5839
GPC2	-3380
GPC5	-3235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GPC6	-11331
AGRN	-11307
SDC4	-10735
HSPG2	-9870
EXT2	-9326
GPC4	-9044
GPC1	-8024
SDC1	-7206
SDC3	-6862
EXT1	-6377
SDC2	-5839
GPC2	-3380
GPC5	-3235

---

Defective EXT2 causes exostoses 2

Defective EXT2 causes exostoses 2

	271
set	Defective EXT2 causes exostoses 2
setSize	13
pANOVA	4.77e-06
s.dist	-0.733
p.adjustANOVA	2.44e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GPC6	-11331
AGRN	-11307
SDC4	-10735
HSPG2	-9870
EXT2	-9326
GPC4	-9044
GPC1	-8024
SDC1	-7206
SDC3	-6862
EXT1	-6377
SDC2	-5839
GPC2	-3380
GPC5	-3235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GPC6	-11331
AGRN	-11307
SDC4	-10735
HSPG2	-9870
EXT2	-9326
GPC4	-9044
GPC1	-8024
SDC1	-7206
SDC3	-6862
EXT1	-6377
SDC2	-5839
GPC2	-3380
GPC5	-3235

---

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

	1477
set	tRNA processing in the mitochondrion
setSize	20
pANOVA	1.43e-08
s.dist	0.732
p.adjustANOVA	1.35e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-CYB	14772
MT-ND2	14771
MT-ND3	14769
MT-CO2	14768
MT-CO1	14766
MT-ND1	14765
MT-CO3	14764
MT-ND4	14762
MT-ND4L	14760
MT-RNR1	14757
MT-RNR2	14756
MT-ND6	14633
MT-ATP6	14606
MT-ND5	14600
MT-ATP8	14192
HSD17B10	13513
TRMT10C	4645
ELAC2	-1278
TRNT1	-3642
PRORP	-8469

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-CYB	14772
MT-ND2	14771
MT-ND3	14769
MT-CO2	14768
MT-CO1	14766
MT-ND1	14765
MT-CO3	14764
MT-ND4	14762
MT-ND4L	14760
MT-RNR1	14757
MT-RNR2	14756
MT-ND6	14633
MT-ATP6	14606
MT-ND5	14600
MT-ATP8	14192
HSD17B10	13513
TRMT10C	4645
ELAC2	-1278
TRNT1	-3642
PRORP	-8469

---

Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the early endosome membrane

	1278
set	Synthesis of PIPs at the early endosome membrane
setSize	16
pANOVA	4.19e-07
s.dist	-0.73
p.adjustANOVA	2.92e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTMR12	-11240
PIKFYVE	-10408
PIK3C2A	-9621
PIK3R4	-9524
MTMR2	-9438
INPP4A	-8999
MTMR4	-8979
INPP5F	-8487
PIK3C3	-7967
MTM1	-7910
VAC14	-7876
PI4K2B	-7570
PI4K2A	-6857
MTMR10	-6497
FIG4	-5627
INPP4B	1266

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTMR12	-11240
PIKFYVE	-10408
PIK3C2A	-9621
PIK3R4	-9524
MTMR2	-9438
INPP4A	-8999
MTMR4	-8979
INPP5F	-8487
PIK3C3	-7967
MTM1	-7910
VAC14	-7876
PI4K2B	-7570
PI4K2A	-6857
MTMR10	-6497
FIG4	-5627
INPP4B	1266

---

Complex I biogenesis

Complex I biogenesis

	211
set	Complex I biogenesis
setSize	57
pANOVA	1.31e-21
s.dist	0.73
p.adjustANOVA	5.88e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND2	14771
MT-ND3	14769
MT-ND1	14765
MT-ND4	14762
NDUFB1	14751
NDUFV2	14736
NDUFS5	14733
NDUFA7	14731
NDUFA1	14715
NDUFA2	14713
NDUFAF3	14700
NDUFA3	14672
NDUFA12	14637
MT-ND6	14633
NDUFB8	14627
MT-ND5	14600
NDUFB4	14596
NDUFA13	14559
NDUFA6	14489
NDUFA8	14488

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND2	14771
MT-ND3	14769
MT-ND1	14765
MT-ND4	14762
NDUFB1	14751
NDUFV2	14736
NDUFS5	14733
NDUFA7	14731
NDUFA1	14715
NDUFA2	14713
NDUFAF3	14700
NDUFA3	14672
NDUFA12	14637
MT-ND6	14633
NDUFB8	14627
MT-ND5	14600
NDUFB4	14596
NDUFA13	14559
NDUFA6	14489
NDUFA8	14488
NDUFA11	14439
NDUFB9	14393
NDUFS8	14361
NDUFS3	14313
NDUFB10	14169
NDUFAF2	14161
NDUFB2	14098
NDUFB7	14030
NDUFC1	14023
NDUFS7	13997
NDUFV3	13890
COA1	13884
NDUFB6	13749
NDUFS6	13691
NDUFB3	13629
NDUFB11	13161
NDUFC2	12983
ACAD9	12951
NDUFA5	12663
NDUFAF6	12067
NDUFA9	11918
ECSIT	11669
TMEM126B	11368
NDUFAF5	11271
NDUFAF4	11158
NDUFAF1	11010
NDUFV1	10505
NDUFAF7	10405
NDUFAB1	10262
TMEM186	6002
NDUFS4	4585
TIMMDC1	-3430
NDUFA10	-4388
NDUFB5	-5177
NDUFS1	-7143
NUBPL	-8112
NDUFS2	-10170

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	111
set	Beta-catenin phosphorylation cascade
setSize	17
pANOVA	1.86e-07
s.dist	-0.73
p.adjustANOVA	1.37e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321
FRAT2	-2944
FRAT1	-2426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNB1	-11218
PPP2R5D	-11215
CSNK1A1	-10939
GSK3B	-10857
PPP2R5E	-10593
APC	-10339
PPP2CB	-10130
PPP2R5A	-9682
AMER1	-8228
AXIN1	-7360
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321
FRAT2	-2944
FRAT1	-2426

---

Signaling by PDGFRA extracellular domain mutants

Signaling by PDGFRA extracellular domain mutants

	1229
set	Signaling by PDGFRA extracellular domain mutants
setSize	12
pANOVA	1.41e-05
s.dist	-0.724
p.adjustANOVA	6.37e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	-11184
STAT3	-10772
GRB2	-10626
PIK3CB	-10352
STAT1	-10345
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
KRAS	-8721
PIK3R2	-5950
HRAS	13906

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	-11184
STAT3	-10772
GRB2	-10626
PIK3CB	-10352
STAT1	-10345
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
KRAS	-8721
PIK3R2	-5950
HRAS	13906

---

Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

	1230
set	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
setSize	12
pANOVA	1.41e-05
s.dist	-0.724
p.adjustANOVA	6.37e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	-11184
STAT3	-10772
GRB2	-10626
PIK3CB	-10352
STAT1	-10345
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
KRAS	-8721
PIK3R2	-5950
HRAS	13906

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	-11184
STAT3	-10772
GRB2	-10626
PIK3CB	-10352
STAT1	-10345
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
KRAS	-8721
PIK3R2	-5950
HRAS	13906

---

Non-integrin membrane-ECM interactions

Non-integrin membrane-ECM interactions

	782
set	Non-integrin membrane-ECM interactions
setSize	42
pANOVA	8.66e-16
s.dist	-0.717
p.adjustANOVA	2e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	-11388
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
AGRN	-11307
ITGA6	-11286
PDGFB	-11280
ITGAV	-11113
TNC	-10940
LAMB2	-10934
ACTN1	-10918
SDC4	-10735
LAMA5	-10549
PRKCA	-10498
LAMA4	-10450
LAMB1	-10431
ITGB5	-10206
LAMA1	-10193
HSPG2	-9870

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	-11388
LAMB3	-11357
LAMC1	-11329
ITGB1	-11317
ITGA2	-11315
AGRN	-11307
ITGA6	-11286
PDGFB	-11280
ITGAV	-11113
TNC	-10940
LAMB2	-10934
ACTN1	-10918
SDC4	-10735
LAMA5	-10549
PRKCA	-10498
LAMA4	-10450
LAMB1	-10431
ITGB5	-10206
LAMA1	-10193
HSPG2	-9870
TGFB1	-8918
CASK	-8743
DAG1	-8675
ITGB4	-8554
DDR1	-8308
DDR2	-8017
NTN4	-7805
THBS1	-7620
PDGFA	-7510
SDC1	-7206
SDC3	-6862
LAMC2	-6635
SDC2	-5839
FGF2	-5306
TRAPPC4	-4762
LAMA2	-4266
LAMC3	-2462
NRXN1	150
DMD	994
TTR	2169
VTN	4190
LAMA3	5212

---

Viral mRNA Translation

Viral mRNA Translation

	1429
set	Viral mRNA Translation
setSize	87
pANOVA	6.88e-31
s.dist	0.716
p.adjustANOVA	8.48e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564
RPL28	14550
RPS16	14529
RPS11	14523
RPL23	14510
RPL29	14503
RPL19	14499
RPL17	14497
RPS15	14496
RPS19	14476
RPL36	14456
RPL9	14394
RPL18	14388
RPL35A	14377
RPL26L1	14358
RPS27L	14338
RPS8	14333
RPLP1	14319
RPL6	14318
RPL36AL	14290
RPS25	14278
RPL37A	14263
RPL26	14246
RPS13	14240
RPL13	14186
RPL4	14145
RPS28	14071
RPS14	14014
RPS6	13991
RPL11	13968
RPS4X	13824
RPL22L1	13806
RPL15	13737
RPS3	13719
RPL5	13658
RPL39	13544
RPL18A	13507
RPS23	13488
RPL7A	13286
UBA52	13217
RPS17	13209
RPL27	13203
RPS12	13178
RPSA	13154
RPS27	12843
RPL30	12665
RPS10	12226
RPL8	11881
RPS9	11743
RPL22	11069
RPS29	10608
RPS2	10438
RPL3L	9364
RPL13A	8281
RPS27A	7697
RPS3A	6206
RPL21	6069
RPL10	1775
RPL3	-4638
RPL23A	-5359
RPL41	-6177
RPL39L	-6371
RPLP0	-7433
DNAJC3	-7651
GRSF1	-7945
RPS5	-8067
RPL10A	-8314
RPL7	-8891

---

Peptide chain elongation

Peptide chain elongation

	852
set	Peptide chain elongation
setSize	87
pANOVA	7.93e-31
s.dist	0.715
p.adjustANOVA	9.02e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564
RPL28	14550
RPS16	14529
RPS11	14523
RPL23	14510
RPL29	14503
RPL19	14499
RPL17	14497
RPS15	14496
RPS19	14476
RPL36	14456
RPL9	14394
RPL18	14388
RPL35A	14377
RPL26L1	14358
RPS27L	14338
RPS8	14333
RPLP1	14319
RPL6	14318
RPL36AL	14290
RPS25	14278
RPL37A	14263
RPL26	14246
RPS13	14240
RPL13	14186
RPL4	14145
RPS28	14071
RPS14	14014
RPS6	13991
RPL11	13968
RPS4X	13824
RPL22L1	13806
RPL15	13737
RPS3	13719
RPL5	13658
RPL39	13544
RPL18A	13507
RPS23	13488
RPL7A	13286
UBA52	13217
RPS17	13209
RPL27	13203
RPS12	13178
RPSA	13154
RPS27	12843
RPL30	12665
RPS10	12226
RPL8	11881
RPS9	11743
RPL22	11069
RPS29	10608
RPS2	10438
RPL3L	9364
RPL13A	8281
RPS27A	7697
RPS3A	6206
RPL21	6069
RPL10	1775
RPL3	-4638
RPL23A	-5359
RPL41	-6177
RPL39L	-6371
RPLP0	-7433
EEF1A1	-7541
RPS5	-8067
RPL10A	-8314
RPL7	-8891
EEF2	-8912

---

Signaling by PDGFR in disease

Signaling by PDGFR in disease

	1228
set	Signaling by PDGFR in disease
setSize	19
pANOVA	8.03e-08
s.dist	-0.711
p.adjustANOVA	6.49e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	-11184
STAT3	-10772
GRB2	-10626
GOLGA4	-10362
PIK3CB	-10352
STAT1	-10345
STRN	-10181
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
KRAS	-8721
KANK1	-8588
WDR48	-7167
PIK3R2	-5950
ETV6	-5676
KDR	-4602
FIP1L1	-4599
HRAS	13906

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	-11184
STAT3	-10772
GRB2	-10626
GOLGA4	-10362
PIK3CB	-10352
STAT1	-10345
STRN	-10181
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
KRAS	-8721
KANK1	-8588
WDR48	-7167
PIK3R2	-5950
ETV6	-5676
KDR	-4602
FIP1L1	-4599
HRAS	13906

---

DCC mediated attractive signaling

DCC mediated attractive signaling

	245
set	DCC mediated attractive signaling
setSize	14
pANOVA	4.24e-06
s.dist	-0.71
p.adjustANOVA	2.22e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DOCK1	-10879
PTK2	-10250
NCK1	-10095
NTN1	-9908
ABLIM3	-9474
DCC	-9460
WASL	-8689
CDC42	-8552
SRC	-7386
TRIO	-6874
ABLIM1	-5575
RAC1	-3826
FYN	-3672
ABLIM2	-1605

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DOCK1	-10879
PTK2	-10250
NCK1	-10095
NTN1	-9908
ABLIM3	-9474
DCC	-9460
WASL	-8689
CDC42	-8552
SRC	-7386
TRIO	-6874
ABLIM1	-5575
RAC1	-3826
FYN	-3672
ABLIM2	-1605

---

Activation of RAC1

Activation of RAC1

	46
set	Activation of RAC1
setSize	13
pANOVA	9.42e-06
s.dist	-0.709
p.adjustANOVA	4.53e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ROBO1	-10780
PAK2	-10387
NCK1	-10095
SOS1	-10023
PAK1	-9837
SOS2	-9419
SLIT2	-9320
PAK3	-7519
PAK4	-6964
NCK2	-6728
PAK5	-4128
RAC1	-3826
PAK6	418

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ROBO1	-10780
PAK2	-10387
NCK1	-10095
SOS1	-10023
PAK1	-9837
SOS2	-9419
SLIT2	-9320
PAK3	-7519
PAK4	-6964
NCK2	-6728
PAK5	-4128
RAC1	-3826
PAK6	418

---

FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes

	402
set	FOXO-mediated transcription of cell cycle genes
setSize	15
pANOVA	2.13e-06
s.dist	-0.707
p.adjustANOVA	1.19e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CAV1	-11260
CDKN1A	-11157
RBL2	-11019
FOXO3	-10708
SMAD4	-10684
FOXO1	-10285
CDKN1B	-9434
SMAD2	-9233
BTG1	-8909
CCNG2	-8722
SMAD3	-8597
FOXO4	-7482
KLF4	-7151
GADD45A	-1324
PCBP4	12731

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CAV1	-11260
CDKN1A	-11157
RBL2	-11019
FOXO3	-10708
SMAD4	-10684
FOXO1	-10285
CDKN1B	-9434
SMAD2	-9233
BTG1	-8909
CCNG2	-8722
SMAD3	-8597
FOXO4	-7482
KLF4	-7151
GADD45A	-1324
PCBP4	12731

---

HDMs demethylate histones

HDMs demethylate histones

	509
set	HDMs demethylate histones
setSize	22
pANOVA	1.56e-08
s.dist	-0.696
p.adjustANOVA	1.46e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KDM5B	-11193
KDM1B	-10910
KDM4C	-10902
KDM5A	-10282
KDM7A	-10275
KDM4B	-10186
KDM3B	-10032
KDM5C	-9480
KDM1A	-9433
KDM6A	-9040
KDM4A	-8582
JMJD6	-8560
KDM6B	-8163
KDM2B	-8140
KDM2A	-7781
PHF8	-7730
KDM3A	-7043
ARID5B	-6158
PHF2	-5878
KDM4D	-5486

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KDM5B	-11193.0
KDM1B	-10910.0
KDM4C	-10902.0
KDM5A	-10282.0
KDM7A	-10275.0
KDM4B	-10186.0
KDM3B	-10032.0
KDM5C	-9480.0
KDM1A	-9433.0
KDM6A	-9040.0
KDM4A	-8582.0
JMJD6	-8560.0
KDM6B	-8163.0
KDM2B	-8140.0
KDM2A	-7781.0
PHF8	-7730.0
KDM3A	-7043.0
ARID5B	-6158.0
PHF2	-5878.0
KDM4D	-5486.0
H3C1	3171.0
H3C15	9115.5

---

Adenylate cyclase inhibitory pathway

Adenylate cyclase inhibitory pathway

	61
set	Adenylate cyclase inhibitory pathway
setSize	12
pANOVA	3.89e-05
s.dist	-0.686
p.adjustANOVA	0.000158

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY1	-11110
GNAI3	-10973
ADCY6	-10943
ADCY7	-10524
ADCY9	-9337
GNAI1	-9293
ADCY3	-7605
ADCY5	-6394
GNAL	-3771
GNAI2	-3728
ADCY2	-3004
ADCY4	-619

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY1	-11110
GNAI3	-10973
ADCY6	-10943
ADCY7	-10524
ADCY9	-9337
GNAI1	-9293
ADCY3	-7605
ADCY5	-6394
GNAL	-3771
GNAI2	-3728
ADCY2	-3004
ADCY4	-619

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	377
set	Eukaryotic Translation Termination
setSize	91
pANOVA	1.29e-29
s.dist	0.684
p.adjustANOVA	1.27e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
TRMT112	14645
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
TRMT112	14645
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564
RPL28	14550
RPS16	14529
RPS11	14523
RPL23	14510
RPL29	14503
RPL19	14499
RPL17	14497
RPS15	14496
RPS19	14476
RPL36	14456
RPL9	14394
RPL18	14388
RPL35A	14377
RPL26L1	14358
RPS27L	14338
RPS8	14333
RPLP1	14319
RPL6	14318
RPL36AL	14290
RPS25	14278
RPL37A	14263
RPL26	14246
RPS13	14240
RPL13	14186
RPL4	14145
RPS28	14071
RPS14	14014
RPS6	13991
RPL11	13968
RPS4X	13824
RPL22L1	13806
RPL15	13737
RPS3	13719
RPL5	13658
RPL39	13544
RPL18A	13507
RPS23	13488
RPL7A	13286
UBA52	13217
RPS17	13209
RPL27	13203
RPS12	13178
RPSA	13154
RPS27	12843
RPL30	12665
RPS10	12226
N6AMT1	12141
RPL8	11881
RPS9	11743
RPL22	11069
RPS29	10608
RPS2	10438
RPL3L	9364
RPL13A	8281
RPS27A	7697
RPS3A	6206
RPL21	6069
RPL10	1775
RPL3	-4638
RPL23A	-5359
RPL41	-6177
RPL39L	-6371
GSPT2	-6829
RPLP0	-7433
RPS5	-8067
RPL10A	-8314
APEH	-8673
RPL7	-8891
ETF1	-9598
GSPT1	-10363

---

Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the late endosome membrane

	1279
set	Synthesis of PIPs at the late endosome membrane
setSize	11
pANOVA	8.49e-05
s.dist	-0.684
p.adjustANOVA	0.000319

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIKFYVE	-10408
PIK3C2A	-9621
PIK3R4	-9524
MTMR2	-9438
MTMR4	-8979
MTMR9	-8214
PIK3C3	-7967
MTM1	-7910
VAC14	-7876
FIG4	-5627
MTMR7	5748

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIKFYVE	-10408
PIK3C2A	-9621
PIK3R4	-9524
MTMR2	-9438
MTMR4	-8979
MTMR9	-8214
PIK3C3	-7967
MTM1	-7910
VAC14	-7876
FIG4	-5627
MTMR7	5748

---

ERK/MAPK targets

ERK/MAPK targets

	356
set	ERK/MAPK targets
setSize	22
pANOVA	2.97e-08
s.dist	-0.682
p.adjustANOVA	2.66e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP4	-11285
PPP2R5D	-11215
MAPK1	-11008
DUSP7	-10143
PPP2CB	-10130
RPS6KA3	-9604
DUSP3	-9469
MAPK3	-9373
RPS6KA2	-9203
RPS6KA1	-7863
MAPK14	-7640
PPP2CA	-7327
VRK3	-7235
RPS6KA5	-7165
DUSP6	-6006
MEF2A	-5794
PPP2R1B	-5567
PPP2R1A	-4930
MAPK7	-4670
MEF2C	-4363

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP4	-11285
PPP2R5D	-11215
MAPK1	-11008
DUSP7	-10143
PPP2CB	-10130
RPS6KA3	-9604
DUSP3	-9469
MAPK3	-9373
RPS6KA2	-9203
RPS6KA1	-7863
MAPK14	-7640
PPP2CA	-7327
VRK3	-7235
RPS6KA5	-7165
DUSP6	-6006
MEF2A	-5794
PPP2R1B	-5567
PPP2R1A	-4930
MAPK7	-4670
MEF2C	-4363
ELK1	-3995
MAPK11	4949

---

Selenocysteine synthesis

Selenocysteine synthesis

	1146
set	Selenocysteine synthesis
setSize	91
pANOVA	3.21e-29
s.dist	0.68
p.adjustANOVA	2.97e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564
RPL28	14550
RPS16	14529
RPS11	14523
RPL23	14510
RPL29	14503
RPL19	14499
RPL17	14497
RPS15	14496
RPS19	14476
RPL36	14456
RPL9	14394
RPL18	14388
RPL35A	14377
RPL26L1	14358
RPS27L	14338
RPS8	14333
RPLP1	14319
RPL6	14318
RPL36AL	14290
RPS25	14278
RPL37A	14263
RPL26	14246
RPS13	14240
RPL13	14186
RPL4	14145
RPS28	14071
RPS14	14014
RPS6	13991
RPL11	13968
RPS4X	13824
RPL22L1	13806
RPL15	13737
RPS3	13719
RPL5	13658
RPL39	13544
RPL18A	13507
RPS23	13488
RPL7A	13286
UBA52	13217
RPS17	13209
RPL27	13203
RPS12	13178
RPSA	13154
RPS27	12843
RPL30	12665
RPS10	12226
RPL8	11881
RPS9	11743
RPL22	11069
PSTK	10855
RPS29	10608
RPS2	10438
RPL3L	9364
RPL13A	8281
RPS27A	7697
RPS3A	6206
RPL21	6069
RPL10	1775
SEPHS2	-372
EEFSEC	-3593
RPL3	-4638
SEPSECS	-5198
RPL23A	-5359
RPL41	-6177
RPL39L	-6371
SECISBP2	-6619
RPLP0	-7433
RPS5	-8067
RPL10A	-8314
RPL7	-8891
SARS1	-9523

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	375
set	Eukaryotic Translation Elongation
setSize	92
pANOVA	5.39e-29
s.dist	0.673
p.adjustANOVA	4.43e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL38	14728
RPL14	14725
RPL37	14722
RPL31	14719
RPS26	14702
FAU	14690
RPL35	14685
RPS20	14683
RPL27A	14639
RPS24	14622
RPS21	14610
RPL36A	14598
RPLP2	14587
RPL34	14584
RPL24	14583
RPL12	14580
RPS15A	14577
RPS18	14572
RPL32	14571
RPS7	14564
RPL28	14550
RPS16	14529
RPS11	14523
RPL23	14510
RPL29	14503
RPL19	14499
RPL17	14497
RPS15	14496
RPS19	14476
RPL36	14456
RPL9	14394
RPL18	14388
RPL35A	14377
RPL26L1	14358
RPS27L	14338
RPS8	14333
RPLP1	14319
RPL6	14318
RPL36AL	14290
RPS25	14278
RPL37A	14263
RPL26	14246
RPS13	14240
RPL13	14186
RPL4	14145
RPS28	14071
RPS14	14014
RPS6	13991
RPL11	13968
RPS4X	13824
RPL22L1	13806
RPL15	13737
RPS3	13719
RPL5	13658
RPL39	13544
RPL18A	13507
RPS23	13488
RPL7A	13286
UBA52	13217
RPS17	13209
RPL27	13203
RPS12	13178
RPSA	13154
RPS27	12843
RPL30	12665
EEF1D	12605
RPS10	12226
RPL8	11881
RPS9	11743
RPL22	11069
RPS29	10608
RPS2	10438
EEF1B2	9965
RPL3L	9364
RPL13A	8281
RPS27A	7697
RPS3A	6206
RPL21	6069
RPL10	1775
EEF1A2	-3550
RPL3	-4638
RPL23A	-5359
EEF1G	-5887
RPL41	-6177
RPL39L	-6371
RPLP0	-7433
EEF1A1	-7541
RPS5	-8067
RPL10A	-8314
EEF1A1P5	-8339
RPL7	-8891
EEF2	-8912

---

Platelet sensitization by LDL

Platelet sensitization by LDL

	883
set	Platelet sensitization by LDL
setSize	15
pANOVA	6.79e-06
s.dist	-0.671
p.adjustANOVA	3.36e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11215
PPP2R5E	-10593
PPP2CB	-10130
PPP2R5A	-9682
PTPN11	-9492
PLA2G4A	-9352
LRP8	-9305
PECAM1	-7865
MAPK14	-7640
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321
PTPN6	6610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11215
PPP2R5E	-10593
PPP2CB	-10130
PPP2R5A	-9682
PTPN11	-9492
PLA2G4A	-9352
LRP8	-9305
PECAM1	-7865
MAPK14	-7640
PPP2CA	-7327
PPP2R1B	-5567
PPP2R5C	-5404
PPP2R1A	-4930
PPP2R5B	-4321
PTPN6	6610

---

rRNA processing in the mitochondrion

rRNA processing in the mitochondrion

	1471
set	rRNA processing in the mitochondrion
setSize	24
pANOVA	1.27e-08
s.dist	0.671
p.adjustANOVA	1.21e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-CYB	14772
MT-ND2	14771
MT-ND3	14769
MT-CO2	14768
MT-CO1	14766
MT-ND1	14765
MT-CO3	14764
MT-ND4	14762
MT-ND4L	14760
MT-RNR1	14757
MT-RNR2	14756
MT-ATP6	14606
MT-ND5	14600
MT-ATP8	14192
HSD17B10	13513
MRM2	12429
MTERF4	11344
MRM3	8243
MRM1	8199
TFB1M	5669

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-CYB	14772
MT-ND2	14771
MT-ND3	14769
MT-CO2	14768
MT-CO1	14766
MT-ND1	14765
MT-CO3	14764
MT-ND4	14762
MT-ND4L	14760
MT-RNR1	14757
MT-RNR2	14756
MT-ATP6	14606
MT-ND5	14600
MT-ATP8	14192
HSD17B10	13513
MRM2	12429
MTERF4	11344
MRM3	8243
MRM1	8199
TFB1M	5669
TRMT10C	4645
ELAC2	-1278
PRORP	-8469
NSUN4	-9122

---

Signaling by FLT3 fusion proteins

Signaling by FLT3 fusion proteins

	1200
set	Signaling by FLT3 fusion proteins
setSize	19
pANOVA	4.21e-07
s.dist	-0.67
p.adjustANOVA	2.92e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	-11157
SPTBN1	-11088
GRB2	-10626
TRIP11	-10478
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
STAT5B	-9035
GOLGB1	-8910
GAB2	-8835
KRAS	-8721
ZMYM2	-6904
PIM1	-6662
ETV6	-5676
MYO18A	-4059
NOX4	-3988
STAT5A	-2885
HRAS	13906

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	-11157
SPTBN1	-11088
GRB2	-10626
TRIP11	-10478
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
STAT5B	-9035
GOLGB1	-8910
GAB2	-8835
KRAS	-8721
ZMYM2	-6904
PIM1	-6662
ETV6	-5676
MYO18A	-4059
NOX4	-3988
STAT5A	-2885
HRAS	13906

---

Signaling by FGFR3 fusions in cancer

Signaling by FGFR3 fusions in cancer

	1194
set	Signaling by FGFR3 fusions in cancer
setSize	10
pANOVA	0.000258
s.dist	-0.667
p.adjustANOVA	0.000889

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	-10626
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
FRS2	-9420
KRAS	-8721
GAB1	-8325
FGFR3	-7938
HRAS	13906

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	-10626
SOS1	-10023
NRAS	-9826
PIK3CA	-9701
PIK3R1	-9670
FRS2	-9420
KRAS	-8721
GAB1	-8325
FGFR3	-7938
HRAS	13906

---

Defective B4GALT7 causes EDS, progeroid type

Defective B4GALT7 causes EDS, progeroid type

	267
set	Defective B4GALT7 causes EDS, progeroid type
setSize	18
pANOVA	1.16e-06
s.dist	-0.662
p.adjustANOVA	7.07e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSPG4	-11375
VCAN	-11365
GPC6	-11331
AGRN	-11307
SDC4	-10735
HSPG2	-9870
GPC4	-9044
GPC1	-8024
SDC1	-7206
SDC3	-6862
SDC2	-5839
B4GALT7	-5082
BCAN	-4115
GPC2	-3380
CSPG5	-3264
GPC5	-3235
NCAN	-1857
BGN	-1384

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSPG4	-11375
VCAN	-11365
GPC6	-11331
AGRN	-11307
SDC4	-10735
HSPG2	-9870
GPC4	-9044
GPC1	-8024
SDC1	-7206
SDC3	-6862
SDC2	-5839
B4GALT7	-5082
BCAN	-4115
GPC2	-3380
CSPG5	-3264
GPC5	-3235
NCAN	-1857
BGN	-1384

---

ALK mutants bind TKIs

ALK mutants bind TKIs

	10
set	ALK mutants bind TKIs
setSize	12
pANOVA	7.86e-05
s.dist	-0.658
p.adjustANOVA	0.000299

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTC	-11303
EIF2AK3	-11053
BIRC6	-10900
PRKAR1A	-10732
STRN	-10181
FN1	-9930
PPM1B	-8702
HIP1	-8158
ALK	-6779
EML4	-5902
BCL11A	-2682
NPM1	13339

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTC	-11303
EIF2AK3	-11053
BIRC6	-10900
PRKAR1A	-10732
STRN	-10181
FN1	-9930
PPM1B	-8702
HIP1	-8158
ALK	-6779
EML4	-5902
BCL11A	-2682
NPM1	13339

---

Interleukin-6 signaling

Interleukin-6 signaling

	604
set	Interleukin-6 signaling
setSize	11
pANOVA	0.000174
s.dist	-0.654
p.adjustANOVA	0.00062

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL6R	-11298
CBL	-11081
IL6ST	-10890
STAT3	-10772
STAT1	-10345
JAK1	-9971
PTPN11	-9492
JAK2	-6732
SOCS3	-3875
TYK2	-2862
IL6	11896

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL6R	-11298
CBL	-11081
IL6ST	-10890
STAT3	-10772
STAT1	-10345
JAK1	-9971
PTPN11	-9492
JAK2	-6732
SOCS3	-3875
TYK2	-2862
IL6	11896

---

Cell-extracellular matrix interactions

Cell-extracellular matrix interactions

	171
set	Cell-extracellular matrix interactions
setSize	16
pANOVA	6.27e-06
s.dist	-0.652
p.adjustANOVA	3.11e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FLNA	-11346
FLNC	-11326
ITGB1	-11317
FERMT2	-11153
ACTN1	-10918
LIMS1	-10700
FBLIM1	-9992
PARVB	-8860
PXN	-8213
ARHGEF6	-7685
PARVA	-6809
ILK	-6798
VASP	-6675
LIMS2	-4619
RSU1	6816
TESK1	10249

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FLNA	-11346
FLNC	-11326
ITGB1	-11317
FERMT2	-11153
ACTN1	-10918
LIMS1	-10700
FBLIM1	-9992
PARVB	-8860
PXN	-8213
ARHGEF6	-7685
PARVA	-6809
ILK	-6798
VASP	-6675
LIMS2	-4619
RSU1	6816
TESK1	10249

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.2.2              echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.1               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58                 fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [23] IRanges_2.30.0              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.9                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.7                ggplot2_3.3.6              
## [35] tidyverse_1.3.1             zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.7             polylabelr_0.2.0      
##   [7] splines_4.2.1          BiocParallel_1.30.3    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.3            magrittr_2.0.3        
##  [13] memoise_2.0.1          tzdb_0.3.0             Biostrings_2.64.0     
##  [16] annotate_1.74.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.3             rvest_1.0.2           
##  [22] haven_2.5.0            xfun_0.31              crayon_1.5.1          
##  [25] RCurl_1.98-1.7         jsonlite_1.8.0         genefilter_1.78.0     
##  [28] survival_3.4-0         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.42.0        XVector_0.36.0        
##  [34] webshot_0.5.3          DelayedArray_0.22.0    scales_1.2.0          
##  [37] DBI_1.1.3              Rcpp_1.0.8.3           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.3             RColorBrewer_1.1-3     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.9          XML_3.99-0.10         
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       rlang_1.0.3           
##  [55] later_1.3.0            AnnotationDbi_1.58.0   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.1            cachem_1.0.6          
##  [61] cli_3.3.0              generics_0.1.2         RSQLite_2.2.14        
##  [64] broom_0.8.0            evaluate_0.15          fastmap_1.1.0         
##  [67] yaml_2.3.5             knitr_1.39             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.36.2       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.1        
##  [76] rstudioapi_0.13        png_0.1-7              reprex_2.0.1          
##  [79] geneplotter_1.74.0     bslib_0.3.1            stringi_1.7.6         
##  [82] highr_0.9              lattice_0.20-45        Matrix_1.4-1          
##  [85] vctrs_0.4.1            pillar_1.7.0           lifecycle_1.0.1       
##  [88] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [91] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [94] KernSmooth_2.23-20     gridExtra_2.3          codetools_0.2-18      
##  [97] assertthat_0.2.1       withr_2.5.0            GenomeInfoDbData_1.2.8
## [100] parallel_4.2.1         hms_1.1.1              grid_4.2.1            
## [103] rmarkdown_2.14         shiny_1.7.1            lubridate_1.8.0

END of report