date generated: 2022-08-23

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA 12.7959349
## 7SK        0.6300779
## A1BG       2.0722835
## A1BG-AS1   2.0755802
## A1CF      -1.0374222
## A2M        1.8496539
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2512
num_genes_in_profile 26025
duplicated_genes_present 0
num_profile_genes_in_sets 9028
num_profile_genes_not_in_sets 16997

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2512
num_genesets_excluded 1031
num_genesets_included 1481

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 52 gene sets
set setSize pANOVA s.dist p.adjustANOVA
CLEC7A (Dectin-1) induces NFAT activation 11 1.83e-06 -0.831 1.26e-05
Cohesin Loading onto Chromatin 10 1.05e-05 -0.804 6.09e-05
MET activates RAP1 and RAC1 11 6.11e-06 -0.787 3.76e-05
APC truncation mutants have impaired AXIN binding 14 4.19e-07 -0.781 3.27e-06
AXIN missense mutants destabilize the destruction complex 14 4.19e-07 -0.781 3.27e-06
Signaling by AMER1 mutants 14 4.19e-07 -0.781 3.27e-06
Signaling by APC mutants 14 4.19e-07 -0.781 3.27e-06
Signaling by AXIN mutants 14 4.19e-07 -0.781 3.27e-06
Truncations of AMER1 destabilize the destruction complex 14 4.19e-07 -0.781 3.27e-06
S33 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780 1.45e-06
S37 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780 1.45e-06
S45 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780 1.45e-06
Signaling by CTNNB1 phospho-site mutants 15 1.66e-07 -0.780 1.45e-06
Signaling by GSK3beta mutants 15 1.66e-07 -0.780 1.45e-06
T41 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780 1.45e-06
Signaling by Hippo 20 6.57e-09 -0.749 7.73e-08
Establishment of Sister Chromatid Cohesion 11 1.81e-05 -0.746 9.73e-05
Beta-catenin phosphorylation cascade 17 1.25e-07 -0.740 1.16e-06
ERKs are inactivated 13 4.14e-06 -0.737 2.66e-05
Interleukin-6 signaling 11 3.09e-05 -0.725 1.59e-04
HDMs demethylate histones 22 6.47e-09 -0.715 7.67e-08
Synthesis of PIPs at the late endosome membrane 11 7.55e-05 -0.689 3.46e-04
Deadenylation of mRNA 22 3.47e-08 -0.679 3.45e-07
Unwinding of DNA 12 4.94e-05 0.676 2.39e-04
Cell-extracellular matrix interactions 16 3.25e-06 -0.672 2.14e-05
Ephrin signaling 19 4.19e-07 -0.670 3.27e-06
tRNA processing in the mitochondrion 20 2.52e-07 0.666 2.11e-06
FOXO-mediated transcription of cell cycle genes 15 1.01e-05 -0.658 5.98e-05
RHO GTPases activate KTN1 11 1.59e-04 -0.658 6.76e-04
Synthesis of PIPs at the Golgi membrane 15 1.39e-05 -0.648 7.70e-05
Synthesis of PIPs at the early endosome membrane 16 7.56e-06 -0.646 4.61e-05
RAF-independent MAPK1/3 activation 23 8.89e-08 -0.644 8.44e-07
Signaling by Activin 15 1.82e-05 -0.639 9.75e-05
RORA activates gene expression 18 3.10e-06 -0.635 2.08e-05
Formation of ATP by chemiosmotic coupling 18 3.19e-06 0.634 2.11e-05
ALK mutants bind TKIs 12 1.52e-04 -0.631 6.53e-04
Activation of RAC1 13 8.69e-05 -0.629 3.95e-04
Regulation of PTEN mRNA translation 12 2.31e-04 -0.614 9.32e-04
CTLA4 inhibitory signaling 17 1.21e-05 -0.613 6.77e-05
STAT5 activation downstream of FLT3 ITD mutants 10 8.26e-04 -0.611 2.83e-03
ERK/MAPK targets 22 8.88e-07 -0.605 6.51e-06
Complex I biogenesis 57 5.61e-15 0.598 2.08e-13
Signal transduction by L1 21 2.30e-06 -0.595 1.58e-05
Signaling by Leptin 10 1.11e-03 -0.595 3.70e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.51e-04 -0.594 2.35e-03
Prolonged ERK activation events 14 1.27e-04 -0.591 5.58e-04
Signaling by WNT in cancer 33 4.49e-09 -0.590 5.74e-08
Frs2-mediated activation 12 4.25e-04 -0.587 1.63e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 4.44e-04 -0.585 1.70e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 1.48e-03 -0.580 4.69e-03
MAPK3 (ERK1) activation 10 1.50e-03 -0.580 4.74e-03
MET receptor recycling 10 1.64e-03 -0.575 5.13e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
CLEC7A (Dectin-1) induces NFAT activation 11 1.83e-06 -0.831000 1.26e-05
Cohesin Loading onto Chromatin 10 1.05e-05 -0.804000 6.09e-05
MET activates RAP1 and RAC1 11 6.11e-06 -0.787000 3.76e-05
APC truncation mutants have impaired AXIN binding 14 4.19e-07 -0.781000 3.27e-06
AXIN missense mutants destabilize the destruction complex 14 4.19e-07 -0.781000 3.27e-06
Signaling by AMER1 mutants 14 4.19e-07 -0.781000 3.27e-06
Signaling by APC mutants 14 4.19e-07 -0.781000 3.27e-06
Signaling by AXIN mutants 14 4.19e-07 -0.781000 3.27e-06
Truncations of AMER1 destabilize the destruction complex 14 4.19e-07 -0.781000 3.27e-06
S33 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780000 1.45e-06
S37 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780000 1.45e-06
S45 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780000 1.45e-06
Signaling by CTNNB1 phospho-site mutants 15 1.66e-07 -0.780000 1.45e-06
Signaling by GSK3beta mutants 15 1.66e-07 -0.780000 1.45e-06
T41 mutants of beta-catenin aren’t phosphorylated 15 1.66e-07 -0.780000 1.45e-06
Signaling by Hippo 20 6.57e-09 -0.749000 7.73e-08
Establishment of Sister Chromatid Cohesion 11 1.81e-05 -0.746000 9.73e-05
Beta-catenin phosphorylation cascade 17 1.25e-07 -0.740000 1.16e-06
ERKs are inactivated 13 4.14e-06 -0.737000 2.66e-05
Interleukin-6 signaling 11 3.09e-05 -0.725000 1.59e-04
HDMs demethylate histones 22 6.47e-09 -0.715000 7.67e-08
Synthesis of PIPs at the late endosome membrane 11 7.55e-05 -0.689000 3.46e-04
Deadenylation of mRNA 22 3.47e-08 -0.679000 3.45e-07
Unwinding of DNA 12 4.94e-05 0.676000 2.39e-04
Cell-extracellular matrix interactions 16 3.25e-06 -0.672000 2.14e-05
Ephrin signaling 19 4.19e-07 -0.670000 3.27e-06
tRNA processing in the mitochondrion 20 2.52e-07 0.666000 2.11e-06
FOXO-mediated transcription of cell cycle genes 15 1.01e-05 -0.658000 5.98e-05
RHO GTPases activate KTN1 11 1.59e-04 -0.658000 6.76e-04
Synthesis of PIPs at the Golgi membrane 15 1.39e-05 -0.648000 7.70e-05
Synthesis of PIPs at the early endosome membrane 16 7.56e-06 -0.646000 4.61e-05
RAF-independent MAPK1/3 activation 23 8.89e-08 -0.644000 8.44e-07
Signaling by Activin 15 1.82e-05 -0.639000 9.75e-05
RORA activates gene expression 18 3.10e-06 -0.635000 2.08e-05
Formation of ATP by chemiosmotic coupling 18 3.19e-06 0.634000 2.11e-05
ALK mutants bind TKIs 12 1.52e-04 -0.631000 6.53e-04
Activation of RAC1 13 8.69e-05 -0.629000 3.95e-04
Regulation of PTEN mRNA translation 12 2.31e-04 -0.614000 9.32e-04
CTLA4 inhibitory signaling 17 1.21e-05 -0.613000 6.77e-05
STAT5 activation downstream of FLT3 ITD mutants 10 8.26e-04 -0.611000 2.83e-03
ERK/MAPK targets 22 8.88e-07 -0.605000 6.51e-06
Complex I biogenesis 57 5.61e-15 0.598000 2.08e-13
Signal transduction by L1 21 2.30e-06 -0.595000 1.58e-05
Signaling by Leptin 10 1.11e-03 -0.595000 3.70e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.51e-04 -0.594000 2.35e-03
Prolonged ERK activation events 14 1.27e-04 -0.591000 5.58e-04
Signaling by WNT in cancer 33 4.49e-09 -0.590000 5.74e-08
Frs2-mediated activation 12 4.25e-04 -0.587000 1.63e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 4.44e-04 -0.585000 1.70e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 1.48e-03 -0.580000 4.69e-03
MAPK3 (ERK1) activation 10 1.50e-03 -0.580000 4.74e-03
MET receptor recycling 10 1.64e-03 -0.575000 5.13e-03
Signaling by PDGFR in disease 19 1.63e-05 -0.571000 8.90e-05
Platelet sensitization by LDL 15 1.29e-04 -0.571000 5.62e-04
BMAL1:CLOCK,NPAS2 activates circadian gene expression 26 5.39e-07 -0.568000 4.10e-06
Mitotic Telophase/Cytokinesis 13 3.97e-04 -0.567000 1.53e-03
Heme signaling 42 3.13e-10 -0.561000 5.58e-09
Signaling by PDGFRA extracellular domain mutants 12 7.87e-04 -0.560000 2.72e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.87e-04 -0.560000 2.72e-03
Receptor Mediated Mitophagy 11 1.34e-03 -0.558000 4.29e-03
RHO GTPases Activate WASPs and WAVEs 36 6.89e-09 -0.558000 8.04e-08
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 8.91e-04 -0.554000 3.03e-03
Signaling by ALK fusions and activated point mutants 55 1.16e-12 -0.554000 2.91e-11
Signaling by ALK in cancer 55 1.16e-12 -0.554000 2.91e-11
Adenylate cyclase inhibitory pathway 12 9.22e-04 -0.552000 3.10e-03
Downstream signal transduction 29 2.77e-07 -0.551000 2.29e-06
PKA-mediated phosphorylation of CREB 18 5.38e-05 -0.550000 2.57e-04
Circadian Clock 67 9.84e-15 -0.546000 3.55e-13
Downregulation of SMAD2/3:SMAD4 transcriptional activity 28 5.65e-07 -0.546000 4.27e-06
EGR2 and SOX10-mediated initiation of Schwann cell myelination 25 3.03e-06 -0.539000 2.04e-05
Regulation of signaling by CBL 17 1.25e-04 -0.537000 5.51e-04
p130Cas linkage to MAPK signaling for integrins 12 1.29e-03 -0.536000 4.17e-03
Processing and activation of SUMO 10 3.31e-03 -0.536000 9.35e-03
Nephrin family interactions 20 3.53e-05 -0.534000 1.78e-04
PKA activation 16 2.23e-04 -0.533000 9.08e-04
FCGR3A-mediated phagocytosis 56 6.00e-12 -0.531000 1.31e-10
Leishmania phagocytosis 56 6.00e-12 -0.531000 1.31e-10
Parasite infection 56 6.00e-12 -0.531000 1.31e-10
Activation of BAD and translocation to mitochondria 15 3.81e-04 -0.530000 1.48e-03
Transcriptional activation of mitochondrial biogenesis 53 2.76e-11 -0.528000 5.68e-10
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 6.08e-07 -0.526000 4.52e-06
RHOV GTPase cycle 37 3.16e-08 -0.525000 3.17e-07
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 5.48e-06 -0.525000 3.44e-05
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.29e-07 -0.524000 3.31e-06
N-Glycan antennae elongation 14 6.80e-04 -0.524000 2.44e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 1.45e-10 -0.524000 2.79e-09
Aflatoxin activation and detoxification 14 7.22e-04 0.522000 2.55e-03
MECP2 regulates neuronal receptors and channels 17 2.04e-04 -0.520000 8.46e-04
COPI-mediated anterograde transport 79 1.84e-15 -0.517000 7.36e-14
DNA strand elongation 32 4.27e-07 0.516000 3.31e-06
STAT3 nuclear events downstream of ALK signaling 10 4.75e-03 -0.516000 1.28e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 4.10e-11 -0.514000 8.20e-10
Selenocysteine synthesis 91 2.35e-17 0.514000 1.34e-15
Viral mRNA Translation 87 1.17e-16 0.513000 5.77e-15
Peptide chain elongation 87 1.23e-16 0.513000 5.86e-15
Downregulation of TGF-beta receptor signaling 26 6.08e-06 -0.512000 3.75e-05
Postmitotic nuclear pore complex (NPC) reformation 27 4.10e-06 -0.512000 2.64e-05
Uptake and function of anthrax toxins 11 3.39e-03 -0.510000 9.51e-03
Signaling by KIT in disease 19 1.19e-04 -0.510000 5.25e-04
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 1.19e-04 -0.510000 5.25e-04
Signaling by BMP 23 2.39e-05 -0.509000 1.25e-04
Signaling by NODAL 18 2.08e-04 -0.505000 8.58e-04
RHOBTB1 GTPase cycle 23 2.89e-05 -0.504000 1.50e-04
Growth hormone receptor signaling 20 9.63e-05 -0.504000 4.32e-04
Constitutive Signaling by AKT1 E17K in Cancer 26 9.15e-06 -0.502000 5.49e-05
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 5.95e-03 -0.502000 1.56e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 45 5.71e-09 -0.502000 6.93e-08
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 2.63e-03 -0.501000 7.67e-03
MET promotes cell motility 29 3.39e-06 -0.498000 2.21e-05
Signaling by TGF-beta Receptor Complex 74 1.44e-13 -0.497000 4.44e-12
VxPx cargo-targeting to cilium 19 1.85e-04 -0.495000 7.80e-04
Response to metal ions 10 6.72e-03 0.495000 1.73e-02
Activation of gene expression by SREBF (SREBP) 42 2.92e-08 -0.494000 3.00e-07
Eukaryotic Translation Termination 91 3.39e-16 0.494000 1.57e-14
Activation of the TFAP2 (AP-2) family of transcription factors 11 4.57e-03 -0.494000 1.24e-02
Nucleotide biosynthesis 12 3.28e-03 -0.490000 9.27e-03
RAC2 GTPase cycle 86 3.80e-15 -0.490000 1.44e-13
Caspase activation via Dependence Receptors in the absence of ligand 10 7.66e-03 -0.487000 1.94e-02
Citric acid cycle (TCA cycle) 22 8.12e-05 -0.485000 3.70e-04
rRNA processing in the mitochondrion 24 3.95e-05 0.485000 1.97e-04
RAC3 GTPase cycle 91 1.34e-15 -0.484000 5.53e-14
Spry regulation of FGF signaling 16 8.46e-04 -0.482000 2.89e-03
RHOU GTPase cycle 40 1.39e-07 -0.481000 1.27e-06
Signaling by FLT3 ITD and TKD mutants 16 9.09e-04 -0.479000 3.07e-03
Eukaryotic Translation Elongation 92 2.23e-15 0.478000 8.69e-14
Interleukin-27 signaling 10 8.89e-03 -0.478000 2.21e-02
DCC mediated attractive signaling 14 1.97e-03 -0.478000 6.04e-03
STING mediated induction of host immune responses 15 1.37e-03 -0.477000 4.36e-03
Miscellaneous transport and binding events 23 7.52e-05 -0.477000 3.46e-04
Signaling by TGFB family members 98 4.54e-16 -0.474000 2.04e-14
Regulation of RUNX1 Expression and Activity 18 5.03e-04 -0.474000 1.86e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 125 5.77e-20 0.473000 4.27e-18
Gastrin-CREB signalling pathway via PKC and MAPK 17 7.33e-04 -0.473000 2.58e-03
TBC/RABGAPs 43 8.11e-08 -0.473000 7.80e-07
Signaling by FGFR3 fusions in cancer 10 9.76e-03 -0.472000 2.40e-02
RHOF GTPase cycle 41 1.83e-07 -0.471000 1.57e-06
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 24 6.75e-05 -0.470000 3.17e-04
Insulin processing 25 4.91e-05 -0.469000 2.39e-04
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.42e-03 -0.468000 7.19e-03
Pre-NOTCH Processing in Golgi 18 6.47e-04 -0.464000 2.34e-03
COPI-independent Golgi-to-ER retrograde traffic 33 3.97e-06 -0.464000 2.57e-05
RHOC GTPase cycle 72 1.03e-11 -0.463000 2.17e-10
TGF-beta receptor signaling activates SMADs 32 5.84e-06 -0.463000 3.63e-05
AKT phosphorylates targets in the cytosol 14 2.72e-03 -0.463000 7.90e-03
Signaling by FLT3 fusion proteins 19 4.90e-04 -0.462000 1.83e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 12 5.66e-03 -0.461000 1.49e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 7.22e-04 -0.460000 2.55e-03
Regulation of IFNA signaling 12 6.01e-03 -0.458000 1.57e-02
RHOH GTPase cycle 35 2.73e-06 -0.458000 1.85e-05
IRE1alpha activates chaperones 50 2.46e-08 -0.456000 2.59e-07
Recycling pathway of L1 27 4.17e-05 -0.455000 2.06e-04
Leading Strand Synthesis 14 3.21e-03 0.455000 9.14e-03
Polymerase switching 14 3.21e-03 0.455000 9.14e-03
Regulation of actin dynamics for phagocytic cup formation 58 2.07e-09 -0.455000 2.86e-08
Lysosphingolipid and LPA receptors 12 6.57e-03 -0.453000 1.70e-02
PI Metabolism 77 6.67e-12 -0.452000 1.43e-10
MAP kinase activation 63 5.40e-10 -0.452000 8.51e-09
RHOJ GTPase cycle 54 9.16e-09 -0.452000 1.04e-07
FOXO-mediated transcription of cell death genes 15 2.50e-03 -0.451000 7.39e-03
Regulation of IFNG signaling 13 5.03e-03 -0.449000 1.35e-02
RHOBTB GTPase Cycle 35 4.26e-06 -0.449000 2.71e-05
Signal regulatory protein family interactions 11 9.97e-03 -0.449000 2.45e-02
RUNX2 regulates osteoblast differentiation 23 1.99e-04 -0.448000 8.35e-04
DAG and IP3 signaling 38 1.76e-06 -0.448000 1.23e-05
XBP1(S) activates chaperone genes 48 9.96e-08 -0.444000 9.39e-07
FCGR3A-mediated IL10 synthesis 32 1.36e-05 -0.444000 7.60e-05
Fcgamma receptor (FCGR) dependent phagocytosis 82 3.81e-12 -0.443000 8.81e-11
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.08e-03 -0.443000 1.12e-02
Transport of the SLBP Dependant Mature mRNA 36 4.24e-06 -0.443000 2.71e-05
VEGFR2 mediated vascular permeability 26 9.35e-05 -0.443000 4.21e-04
Processive synthesis on the lagging strand 15 3.08e-03 0.441000 8.87e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 3.39e-06 -0.441000 2.21e-05
N-glycan antennae elongation in the medial/trans-Golgi 25 1.37e-04 -0.441000 5.93e-04
Protein methylation 15 3.17e-03 -0.440000 9.06e-03
NOTCH2 intracellular domain regulates transcription 11 1.18e-02 -0.438000 2.83e-02
Zinc transporters 15 3.28e-03 -0.438000 9.27e-03
RAF activation 34 1.01e-05 -0.437000 5.96e-05
Transport to the Golgi and subsequent modification 161 1.43e-21 -0.435000 1.12e-19
Transport of the SLBP independent Mature mRNA 35 8.47e-06 -0.435000 5.14e-05
Lewis blood group biosynthesis 16 2.61e-03 -0.435000 7.62e-03
G-protein mediated events 50 1.10e-07 -0.434000 1.03e-06
Ca-dependent events 34 1.19e-05 -0.434000 6.72e-05
Synaptic adhesion-like molecules 20 7.88e-04 -0.434000 2.72e-03
ER to Golgi Anterograde Transport 131 9.72e-18 -0.433000 6.26e-16
SUMOylation of SUMOylation proteins 35 9.13e-06 -0.433000 5.49e-05
Formation of a pool of free 40S subunits 99 1.00e-13 0.432000 3.23e-12
Syndecan interactions 20 8.45e-04 -0.431000 2.89e-03
Regulation of gene expression by Hypoxia-inducible Factor 11 1.33e-02 -0.431000 3.18e-02
PLC beta mediated events 46 4.40e-07 -0.430000 3.37e-06
Nuclear Events (kinase and transcription factor activation) 60 8.18e-09 -0.430000 9.39e-08
Respiratory electron transport 103 4.49e-14 0.430000 1.55e-12
EPHB-mediated forward signaling 34 1.45e-05 -0.430000 7.99e-05
Defective GALNT12 causes CRCS1 12 1.00e-02 0.429000 2.45e-02
Regulation of KIT signaling 15 4.03e-03 -0.429000 1.11e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 9.70e-13 0.428000 2.52e-11
Synthesis of PIPs at the plasma membrane 50 1.66e-07 -0.428000 1.45e-06
Interleukin-35 Signalling 12 1.04e-02 -0.427000 2.53e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 181 3.41e-23 -0.427000 2.81e-21
PKA activation in glucagon signalling 15 4.33e-03 -0.425000 1.19e-02
CD28 co-stimulation 29 7.42e-05 -0.425000 3.43e-04
Nuclear events stimulated by ALK signaling in cancer 19 1.37e-03 -0.424000 4.37e-03
Sialic acid metabolism 31 5.20e-05 -0.420000 2.50e-04
Lagging Strand Synthesis 20 1.15e-03 0.420000 3.80e-03
Transport of Ribonucleoproteins into the Host Nucleus 32 3.96e-05 -0.420000 1.97e-04
Carnitine metabolism 11 1.60e-02 -0.419000 3.71e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 5.45e-13 0.419000 1.50e-11
Association of TriC/CCT with target proteins during biosynthesis 37 1.03e-05 -0.419000 6.02e-05
Integrin signaling 24 3.86e-04 -0.418000 1.49e-03
VEGFA-VEGFR2 Pathway 91 5.10e-12 -0.418000 1.16e-10
Signaling by NTRK1 (TRKA) 113 1.50e-14 -0.418000 5.30e-13
Gap junction degradation 10 2.21e-02 -0.418000 4.92e-02
Glycolysis 66 4.27e-09 -0.418000 5.55e-08
Signaling by ALK 26 2.30e-04 -0.417000 9.31e-04
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 9.34e-03 -0.416000 2.30e-02
Defective EXT2 causes exostoses 2 13 9.34e-03 -0.416000 2.30e-02
MET activates PTK2 signaling 18 2.24e-03 -0.416000 6.78e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 43 2.34e-06 -0.416000 1.60e-05
Cholesterol biosynthesis 24 4.64e-04 -0.413000 1.75e-03
Regulation of localization of FOXO transcription factors 12 1.33e-02 -0.413000 3.17e-02
Retrograde transport at the Trans-Golgi-Network 49 5.91e-07 -0.412000 4.45e-06
TNFR1-induced proapoptotic signaling 13 1.02e-02 -0.411000 2.50e-02
Signaling by cytosolic FGFR1 fusion mutants 18 2.54e-03 -0.411000 7.46e-03
Sphingolipid de novo biosynthesis 43 3.14e-06 -0.411000 2.09e-05
Signaling by VEGF 100 1.29e-12 -0.410000 3.19e-11
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 7.95e-05 -0.409000 3.64e-04
Signaling by SCF-KIT 41 5.73e-06 -0.409000 3.58e-05
NEP/NS2 Interacts with the Cellular Export Machinery 32 6.24e-05 -0.409000 2.95e-04
Transport of Mature mRNA Derived from an Intronless Transcript 42 4.56e-06 -0.409000 2.89e-05
Signaling by NTRKs 131 7.00e-16 -0.408000 3.05e-14
SUMOylation of ubiquitinylation proteins 39 1.07e-05 -0.407000 6.17e-05
EPHA-mediated growth cone collapse 15 6.32e-03 -0.407000 1.64e-02
IRF3-mediated induction of type I IFN 12 1.47e-02 -0.407000 3.48e-02
Signaling by FGFR4 in disease 11 1.97e-02 -0.406000 4.46e-02
Removal of the Flap Intermediate 14 8.54e-03 0.406000 2.14e-02
RHOG GTPase cycle 74 1.58e-09 -0.406000 2.29e-08
Nuclear import of Rev protein 34 4.34e-05 -0.405000 2.13e-04
ER Quality Control Compartment (ERQC) 21 1.34e-03 -0.404000 4.29e-03
Signaling by Erythropoietin 25 4.72e-04 -0.404000 1.77e-03
VEGFR2 mediated cell proliferation 19 2.31e-03 -0.404000 6.96e-03
VLDLR internalisation and degradation 11 2.07e-02 -0.403000 4.67e-02
Toll Like Receptor 3 (TLR3) Cascade 90 4.45e-11 -0.401000 8.67e-10
activated TAK1 mediates p38 MAPK activation 19 2.47e-03 -0.401000 7.31e-03
CaM pathway 32 8.83e-05 -0.400000 3.98e-04
Calmodulin induced events 32 8.83e-05 -0.400000 3.98e-04
MyD88 cascade initiated on plasma membrane 81 4.86e-10 -0.400000 7.92e-09
Toll Like Receptor 10 (TLR10) Cascade 81 4.86e-10 -0.400000 7.92e-09
Toll Like Receptor 5 (TLR5) Cascade 81 4.86e-10 -0.400000 7.92e-09
Extra-nuclear estrogen signaling 69 9.64e-09 -0.399000 1.07e-07
RHOQ GTPase cycle 58 1.46e-07 -0.399000 1.33e-06
Tie2 Signaling 17 4.41e-03 -0.399000 1.20e-02
Golgi-to-ER retrograde transport 113 2.39e-13 -0.399000 6.95e-12
Receptor-type tyrosine-protein phosphatases 18 3.44e-03 -0.398000 9.62e-03
Interactions of Rev with host cellular proteins 37 2.95e-05 -0.397000 1.52e-04
Molecules associated with elastic fibres 27 3.58e-04 -0.397000 1.40e-03
RUNX2 regulates bone development 30 1.75e-04 -0.396000 7.41e-04
Interactions of Vpr with host cellular proteins 37 3.16e-05 -0.395000 1.61e-04
Vpr-mediated nuclear import of PICs 34 6.86e-05 -0.394000 3.22e-04
RET signaling 37 3.33e-05 -0.394000 1.69e-04
Interleukin-15 signaling 14 1.07e-02 -0.394000 2.60e-02
Signal amplification 28 3.10e-04 -0.394000 1.22e-03
RHOD GTPase cycle 52 8.94e-07 -0.394000 6.52e-06
Regulation of FOXO transcriptional activity by acetylation 10 3.11e-02 -0.394000 6.56e-02
RUNX3 regulates NOTCH signaling 14 1.08e-02 -0.394000 2.61e-02
Membrane Trafficking 581 1.63e-59 -0.393000 1.21e-56
RHOB GTPase cycle 69 1.73e-08 -0.392000 1.86e-07
ISG15 antiviral mechanism 72 8.55e-09 -0.392000 9.74e-08
Interleukin-17 signaling 68 2.32e-08 -0.392000 2.45e-07
Negative regulation of MAPK pathway 43 8.89e-06 -0.391000 5.37e-05
Cytosolic tRNA aminoacylation 24 9.19e-04 -0.391000 3.10e-03
Rev-mediated nuclear export of HIV RNA 35 6.52e-05 -0.390000 3.07e-04
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 27 4.52e-04 -0.390000 1.72e-03
Free fatty acids regulate insulin secretion 10 3.32e-02 -0.389000 6.92e-02
Sema3A PAK dependent Axon repulsion 16 7.14e-03 -0.388000 1.83e-02
Antiviral mechanism by IFN-stimulated genes 80 1.96e-09 -0.388000 2.79e-08
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 5.68e-05 -0.388000 2.71e-04
Intra-Golgi traffic 43 1.13e-05 -0.387000 6.47e-05
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 2.56e-04 -0.386000 1.02e-03
RHOBTB2 GTPase cycle 23 1.38e-03 -0.385000 4.39e-03
Export of Viral Ribonucleoproteins from Nucleus 33 1.30e-04 -0.385000 5.67e-04
SUMOylation of transcription cofactors 44 1.05e-05 -0.384000 6.09e-05
Toll Like Receptor 9 (TLR9) Cascade 91 2.43e-10 -0.384000 4.50e-09
Golgi Associated Vesicle Biogenesis 55 8.53e-07 -0.384000 6.28e-06
The NLRP3 inflammasome 15 1.04e-02 -0.382000 2.53e-02
L1CAM interactions 94 1.52e-10 -0.382000 2.89e-09
CD28 dependent PI3K/Akt signaling 18 5.27e-03 -0.380000 1.40e-02
GAB1 signalosome 17 6.81e-03 -0.379000 1.75e-02
Role of LAT2/NTAL/LAB on calcium mobilization 13 1.80e-02 -0.379000 4.12e-02
SUMOylation of immune response proteins 11 2.98e-02 -0.378000 6.30e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 2.18e-04 -0.378000 8.90e-04
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 2.18e-04 -0.378000 8.90e-04
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 2.76e-03 -0.377000 8.01e-03
Cristae formation 31 3.31e-04 0.372000 1.30e-03
Cellular response to heat stress 96 2.79e-10 -0.372000 5.05e-09
Negative regulation of MET activity 21 3.15e-03 -0.372000 9.04e-03
MyD88-independent TLR4 cascade 94 4.54e-10 -0.372000 7.64e-09
TRIF(TICAM1)-mediated TLR4 signaling 94 4.54e-10 -0.372000 7.64e-09
Gap junction trafficking and regulation 20 4.02e-03 -0.372000 1.11e-02
FCERI mediated Ca+2 mobilization 28 6.68e-04 -0.371000 2.40e-03
Oncogenic MAPK signaling 77 1.73e-08 -0.371000 1.86e-07
COPI-dependent Golgi-to-ER retrograde traffic 80 9.89e-09 -0.371000 1.09e-07
SARS-CoV-2 Infection 71 6.68e-08 -0.370000 6.51e-07
Mitochondrial translation initiation 90 1.33e-09 0.370000 1.97e-08
Netrin-1 signaling 45 1.79e-05 -0.369000 9.66e-05
Notch-HLH transcription pathway 28 7.15e-04 -0.369000 2.54e-03
Rab regulation of trafficking 120 3.10e-12 -0.368000 7.29e-11
Reactions specific to the complex N-glycan synthesis pathway 10 4.38e-02 -0.368000 8.77e-02
G1/S-Specific Transcription 29 5.98e-04 0.368000 2.18e-03
Regulation of TP53 Activity through Acetylation 29 6.14e-04 -0.367000 2.23e-03
Regulation of TP53 Expression and Degradation 36 1.46e-04 -0.366000 6.31e-04
Cargo trafficking to the periciliary membrane 47 1.43e-05 -0.366000 7.91e-05
Mitochondrial translation elongation 90 2.08e-09 0.365000 2.86e-08
Mitochondrial translation termination 90 2.08e-09 0.365000 2.86e-08
Protein ubiquitination 73 6.79e-08 -0.365000 6.58e-07
CD209 (DC-SIGN) signaling 20 4.75e-03 -0.365000 1.28e-02
Vesicle-mediated transport 611 6.59e-54 -0.365000 3.25e-51
Asparagine N-linked glycosylation 278 1.19e-25 -0.364000 1.18e-23
MyD88 dependent cascade initiated on endosome 87 4.31e-09 -0.364000 5.55e-08
Toll Like Receptor 7/8 (TLR7/8) Cascade 87 4.31e-09 -0.364000 5.55e-08
NS1 Mediated Effects on Host Pathways 40 6.96e-05 -0.363000 3.24e-04
Keratan sulfate biosynthesis 24 2.10e-03 -0.363000 6.39e-03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 86 6.11e-09 -0.362000 7.36e-08
PI3K events in ERBB2 signaling 16 1.23e-02 -0.361000 2.95e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.81e-02 -0.361000 7.82e-02
HS-GAG biosynthesis 27 1.17e-03 -0.361000 3.82e-03
Non-integrin membrane-ECM interactions 42 5.30e-05 -0.360000 2.54e-04
Metal ion SLC transporters 24 2.27e-03 -0.360000 6.86e-03
Defective C1GALT1C1 causes TNPS 13 2.49e-02 0.359000 5.40e-02
Assembly and cell surface presentation of NMDA receptors 24 2.32e-03 -0.359000 6.96e-03
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 2.51e-02 -0.359000 5.43e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 94 1.84e-09 -0.359000 2.65e-08
Glutathione conjugation 30 6.81e-04 0.358000 2.44e-03
Endosomal/Vacuolar pathway 12 3.17e-02 -0.358000 6.64e-02
Blood group systems biosynthesis 20 5.54e-03 -0.358000 1.46e-02
CRMPs in Sema3A signaling 16 1.32e-02 -0.358000 3.16e-02
RHO GTPases activate IQGAPs 11 3.99e-02 -0.358000 8.15e-02
Regulation of TP53 Degradation 35 2.51e-04 -0.357000 1.00e-03
RND2 GTPase cycle 41 7.44e-05 -0.357000 3.43e-04
Negative regulation of the PI3K/AKT network 101 5.37e-10 -0.357000 8.51e-09
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 2.10e-02 -0.356000 4.72e-02
Opioid Signalling 81 3.06e-08 -0.356000 3.12e-07
COPII-mediated vesicle transport 66 6.02e-07 -0.355000 4.50e-06
Regulation of MECP2 expression and activity 30 7.66e-04 -0.355000 2.68e-03
SUMOylation of DNA replication proteins 46 3.15e-05 -0.355000 1.61e-04
IRAK2 mediated activation of TAK1 complex 10 5.25e-02 -0.354000 1.02e-01
RAB GEFs exchange GTP for GDP on RABs 88 9.23e-09 -0.354000 1.04e-07
DARPP-32 events 23 3.35e-03 -0.353000 9.42e-03
Listeria monocytogenes entry into host cells 20 6.32e-03 -0.353000 1.64e-02
CaMK IV-mediated phosphorylation of CREB 10 5.43e-02 -0.351000 1.05e-01
Resolution of D-Loop Structures 33 4.75e-04 0.351000 1.78e-03
Folding of actin by CCT/TriC 10 5.45e-02 -0.351000 1.05e-01
Regulation of HSF1-mediated heat shock response 78 8.65e-08 -0.350000 8.27e-07
Cargo concentration in the ER 31 7.41e-04 -0.350000 2.59e-03
p75NTR signals via NF-kB 16 1.56e-02 -0.349000 3.65e-02
Myogenesis 25 2.53e-03 -0.349000 7.43e-03
Inflammasomes 20 7.20e-03 -0.347000 1.84e-02
NOTCH1 Intracellular Domain Regulates Transcription 47 3.86e-05 -0.347000 1.93e-04
Signaling by MET 66 1.11e-06 -0.347000 7.93e-06
Clathrin-mediated endocytosis 137 2.72e-12 -0.346000 6.50e-11
SRP-dependent cotranslational protein targeting to membrane 110 3.95e-10 0.345000 6.88e-09
Defective GALNT3 causes HFTC 12 3.96e-02 0.343000 8.10e-02
Mitochondrial translation 96 6.45e-09 0.343000 7.67e-08
Signalling to ERKs 33 7.24e-04 -0.340000 2.55e-03
Platelet Aggregation (Plug Formation) 29 1.57e-03 -0.339000 4.92e-03
RND3 GTPase cycle 41 1.82e-04 -0.338000 7.68e-04
RND1 GTPase cycle 42 1.52e-04 -0.338000 6.53e-04
Cell-Cell communication 108 1.30e-09 -0.338000 1.94e-08
Signaling by NTRK3 (TRKC) 16 1.96e-02 -0.337000 4.44e-02
E3 ubiquitin ligases ubiquitinate target proteins 53 2.26e-05 -0.336000 1.19e-04
Apoptotic cleavage of cellular proteins 35 5.81e-04 -0.336000 2.13e-03
HSF1 activation 26 3.06e-03 -0.336000 8.83e-03
Selenoamino acid metabolism 115 5.10e-10 0.335000 8.22e-09
Signaling by EGFR 50 4.21e-05 -0.335000 2.07e-04
Physiological factors 10 6.71e-02 -0.334000 1.24e-01
Diseases of signal transduction by growth factor receptors and second messengers 411 2.48e-31 -0.334000 3.67e-29
Regulation of lipid metabolism by PPARalpha 113 8.83e-10 -0.334000 1.36e-08
SARS-CoV Infections 151 1.77e-12 -0.332000 4.30e-11
Resolution of D-loop Structures through Holliday Junction Intermediates 32 1.15e-03 0.332000 3.80e-03
PPARA activates gene expression 111 1.51e-09 -0.332000 2.22e-08
Metabolism of amine-derived hormones 12 4.66e-02 0.332000 9.22e-02
HCMV Early Events 82 2.14e-07 -0.331000 1.82e-06
PI3K/AKT Signaling in Cancer 94 3.11e-08 -0.330000 3.13e-07
NGF-stimulated transcription 38 4.30e-04 -0.330000 1.65e-03
Ovarian tumor domain proteases 38 4.30e-04 -0.330000 1.65e-03
SUMOylation of chromatin organization proteins 57 1.76e-05 -0.329000 9.53e-05
FLT3 Signaling 36 6.49e-04 -0.328000 2.34e-03
EGFR downregulation 31 1.57e-03 -0.328000 4.94e-03
Signaling by BRAF and RAF1 fusions 60 1.15e-05 -0.327000 6.56e-05
ADP signalling through P2Y purinoceptor 1 22 7.98e-03 -0.327000 2.02e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 33 1.19e-03 -0.326000 3.87e-03
Prolactin receptor signaling 11 6.15e-02 -0.326000 1.17e-01
Regulated proteolysis of p75NTR 11 6.26e-02 -0.324000 1.18e-01
Interleukin-20 family signaling 19 1.44e-02 -0.324000 3.43e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 110 4.70e-09 0.323000 5.90e-08
Thrombin signalling through proteinase activated receptors (PARs) 28 3.11e-03 -0.323000 8.94e-03
GPVI-mediated activation cascade 30 2.22e-03 -0.323000 6.73e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling 37 6.83e-04 -0.323000 2.44e-03
PKMTs methylate histone lysines 46 1.55e-04 -0.322000 6.67e-04
Glucagon signaling in metabolic regulation 28 3.19e-03 -0.322000 9.09e-03
Gap junction trafficking 18 1.82e-02 -0.322000 4.16e-02
RHO GTPases activate CIT 19 1.52e-02 -0.322000 3.58e-02
TRAF3-dependent IRF activation pathway 14 3.77e-02 -0.321000 7.76e-02
ERBB2 Regulates Cell Motility 15 3.20e-02 -0.320000 6.70e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.73e-02 -0.319000 1.24e-01
Signaling by RAF1 mutants 36 9.63e-04 -0.318000 3.23e-03
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 17 2.35e-02 -0.317000 5.16e-02
RHOA GTPase cycle 146 3.99e-11 -0.316000 8.08e-10
Ca2+ pathway 59 2.69e-05 -0.316000 1.40e-04
Attenuation phase 23 8.72e-03 -0.316000 2.18e-02
Elastic fibre formation 37 8.91e-04 -0.316000 3.03e-03
L13a-mediated translational silencing of Ceruloplasmin expression 109 1.29e-08 0.315000 1.40e-07
Activation of the pre-replicative complex 33 1.75e-03 0.315000 5.46e-03
EPH-Ephrin signaling 91 2.09e-07 -0.315000 1.79e-06
Negative regulators of DDX58/IFIH1 signaling 35 1.29e-03 -0.314000 4.17e-03
RAC1 GTPase cycle 178 4.59e-13 -0.314000 1.31e-11
FGFR1 mutant receptor activation 29 3.48e-03 -0.313000 9.70e-03
ESR-mediated signaling 176 7.99e-13 -0.313000 2.11e-11
Activation of NMDA receptors and postsynaptic events 70 6.33e-06 -0.312000 3.88e-05
trans-Golgi Network Vesicle Budding 71 5.48e-06 -0.312000 3.44e-05
Diseases associated with visual transduction 10 8.81e-02 0.311000 1.56e-01
Diseases of the neuronal system 10 8.81e-02 0.311000 1.56e-01
Retinoid cycle disease events 10 8.81e-02 0.311000 1.56e-01
Post NMDA receptor activation events 57 4.74e-05 -0.311000 2.31e-04
RHOBTB3 ATPase cycle 10 8.88e-02 -0.311000 1.57e-01
tRNA Aminoacylation 42 4.92e-04 -0.311000 1.83e-03
RHO GTPase cycle 435 8.10e-29 -0.311000 1.00e-26
RAB geranylgeranylation 62 2.36e-05 -0.310000 1.24e-04
Membrane binding and targetting of GAG proteins 14 4.46e-02 -0.310000 8.89e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 4.46e-02 -0.310000 8.89e-02
Intracellular signaling by second messengers 293 6.34e-20 -0.310000 4.47e-18
SUMOylation of RNA binding proteins 47 2.41e-04 -0.309000 9.66e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 35 1.54e-03 -0.309000 4.85e-03
The role of Nef in HIV-1 replication and disease pathogenesis 23 1.04e-02 -0.309000 2.53e-02
Calnexin/calreticulin cycle 26 6.54e-03 -0.308000 1.69e-02
Effects of PIP2 hydrolysis 24 9.04e-03 -0.308000 2.24e-02
G alpha (z) signalling events 40 7.72e-04 -0.307000 2.68e-03
FLT3 signaling in disease 28 4.95e-03 -0.307000 1.33e-02
BBSome-mediated cargo-targeting to cilium 21 1.50e-02 -0.307000 3.55e-02
Nonhomologous End-Joining (NHEJ) 43 5.06e-04 -0.306000 1.87e-03
Cargo recognition for clathrin-mediated endocytosis 99 1.36e-07 -0.306000 1.25e-06
TNFR1-induced NFkappaB signaling pathway 26 6.94e-03 -0.306000 1.78e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 9.43e-02 -0.306000 1.65e-01
Keratan sulfate/keratin metabolism 29 4.45e-03 -0.305000 1.21e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.79e-03 -0.305000 5.54e-03
Selective autophagy 58 6.90e-05 -0.302000 3.22e-04
AKT phosphorylates targets in the nucleus 10 9.93e-02 -0.301000 1.72e-01
Potential therapeutics for SARS 82 2.57e-06 -0.300000 1.75e-05
Signaling by PDGF 53 1.56e-04 -0.300000 6.67e-04
Signaling by FGFR1 in disease 36 1.89e-03 -0.299000 5.84e-03
Diseases associated with glycosylation precursor biosynthesis 18 2.80e-02 -0.299000 5.98e-02
Signaling by NOTCH1 72 1.16e-05 -0.299000 6.61e-05
Laminin interactions 23 1.32e-02 -0.298000 3.16e-02
Mitophagy 28 6.29e-03 -0.298000 1.64e-02
Pentose phosphate pathway 13 6.31e-02 -0.298000 1.18e-01
Autophagy 126 7.68e-09 -0.298000 8.88e-08
Cap-dependent Translation Initiation 117 2.64e-08 0.298000 2.73e-07
Eukaryotic Translation Initiation 117 2.64e-08 0.298000 2.73e-07
mRNA decay by 5’ to 3’ exoribonuclease 15 4.63e-02 -0.297000 9.18e-02
Transcriptional regulation of white adipocyte differentiation 82 3.45e-06 -0.296000 2.24e-05
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.72e-02 -0.296000 9.32e-02
WNT ligand biogenesis and trafficking 24 1.23e-02 -0.295000 2.95e-02
Late Phase of HIV Life Cycle 135 3.16e-09 -0.295000 4.22e-08
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.31e-08 0.294000 6.19e-07
Nonsense-Mediated Decay (NMD) 113 6.31e-08 0.294000 6.19e-07
PI3K events in ERBB4 signaling 10 1.08e-01 -0.293000 1.85e-01
SUMOylation of DNA damage response and repair proteins 76 9.79e-06 -0.293000 5.85e-05
Toll Like Receptor 4 (TLR4) Cascade 124 1.84e-08 -0.292000 1.96e-07
Reduction of cytosolic Ca++ levels 12 7.98e-02 -0.292000 1.43e-01
Signaling by Non-Receptor Tyrosine Kinases 54 2.04e-04 -0.292000 8.46e-04
Signaling by PTK6 54 2.04e-04 -0.292000 8.46e-04
mRNA decay by 3’ to 5’ exoribonuclease 16 4.35e-02 0.291000 8.74e-02
Translation of Structural Proteins 29 6.61e-03 -0.291000 1.71e-02
Nuclear Pore Complex (NPC) Disassembly 36 2.53e-03 -0.291000 7.43e-03
HCMV Infection 106 2.28e-07 -0.291000 1.93e-06
TRAF6 mediated IRF7 activation 16 4.41e-02 -0.291000 8.83e-02
NR1H2 and NR1H3-mediated signaling 43 9.76e-04 -0.291000 3.27e-03
PIP3 activates AKT signaling 256 1.29e-15 -0.290000 5.45e-14
Processing of Intronless Pre-mRNAs 19 2.88e-02 -0.290000 6.13e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 96 9.53e-07 -0.289000 6.82e-06
Toll Like Receptor 2 (TLR2) Cascade 96 9.53e-07 -0.289000 6.82e-06
Toll Like Receptor TLR1:TLR2 Cascade 96 9.53e-07 -0.289000 6.82e-06
Toll Like Receptor TLR6:TLR2 Cascade 96 9.53e-07 -0.289000 6.82e-06
Negative regulation of FGFR1 signaling 31 5.35e-03 -0.289000 1.42e-02
Antigen processing: Ubiquitination & Proteasome degradation 292 2.33e-17 -0.288000 1.34e-15
Chromatin modifying enzymes 225 9.62e-14 -0.288000 3.17e-12
Chromatin organization 225 9.62e-14 -0.288000 3.17e-12
Unfolded Protein Response (UPR) 92 1.96e-06 -0.287000 1.35e-05
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 2.67e-02 -0.286000 5.72e-02
PCNA-Dependent Long Patch Base Excision Repair 21 2.32e-02 0.286000 5.12e-02
eNOS activation 11 1.02e-01 -0.285000 1.76e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 2.08e-02 -0.285000 4.67e-02
Protein-protein interactions at synapses 78 1.37e-05 -0.285000 7.61e-05
Unblocking of NMDA receptors, glutamate binding and activation 19 3.17e-02 -0.285000 6.64e-02
Glutathione synthesis and recycling 12 8.80e-02 0.284000 1.56e-01
HSF1-dependent transactivation 33 4.75e-03 -0.284000 1.28e-02
Translocation of ZAP-70 to Immunological synapse 15 5.69e-02 0.284000 1.09e-01
Activation of the AP-1 family of transcription factors 10 1.20e-01 -0.284000 2.01e-01
Toll-like Receptor Cascades 142 5.27e-09 -0.284000 6.52e-08
Activation of Matrix Metalloproteinases 27 1.09e-02 -0.283000 2.63e-02
Interleukin-7 signaling 23 1.94e-02 -0.282000 4.40e-02
RNA polymerase II transcribes snRNA genes 71 4.09e-05 -0.281000 2.03e-04
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 2.10e-03 -0.281000 6.39e-03
Signaling by RAS mutants 40 2.10e-03 -0.281000 6.39e-03
Signaling by moderate kinase activity BRAF mutants 40 2.10e-03 -0.281000 6.39e-03
Signaling downstream of RAS mutants 40 2.10e-03 -0.281000 6.39e-03
Phospholipid metabolism 190 2.39e-11 -0.281000 4.99e-10
Regulation of expression of SLITs and ROBOs 166 4.35e-10 0.280000 7.48e-09
CDC42 GTPase cycle 153 2.36e-09 -0.279000 3.21e-08
MTOR signalling 40 2.24e-03 -0.279000 6.78e-03
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 644 7.03e-34 -0.279000 1.49e-31
Fanconi Anemia Pathway 36 3.76e-03 0.279000 1.04e-02
Formation of the cornified envelope 31 7.19e-03 -0.279000 1.84e-02
HIV Life Cycle 147 5.28e-09 -0.279000 6.52e-08
Role of phospholipids in phagocytosis 22 2.38e-02 -0.278000 5.21e-02
Deadenylation-dependent mRNA decay 53 4.54e-04 -0.278000 1.72e-03
Nuclear Envelope Breakdown 53 4.65e-04 -0.278000 1.75e-03
Cell junction organization 78 2.19e-05 -0.278000 1.16e-04
Macroautophagy 112 3.72e-07 -0.278000 3.01e-06
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 3.16e-02 -0.278000 6.64e-02
Cytosolic sensors of pathogen-associated DNA 62 1.56e-04 -0.278000 6.67e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 13 8.34e-02 -0.277000 1.48e-01
Signaling by ERBB2 50 6.95e-04 -0.277000 2.47e-03
Semaphorin interactions 60 2.04e-04 -0.277000 8.46e-04
Defective B4GALT7 causes EDS, progeroid type 19 3.65e-02 -0.277000 7.56e-02
Signaling by Rho GTPases 628 1.89e-32 -0.276000 3.49e-30
The citric acid (TCA) cycle and respiratory electron transport 173 3.93e-10 0.275000 6.88e-09
Dopamine Neurotransmitter Release Cycle 22 2.57e-02 -0.275000 5.53e-02
Retrograde neurotrophin signalling 14 7.58e-02 -0.274000 1.37e-01
Cytochrome c-mediated apoptotic response 13 8.75e-02 -0.274000 1.55e-01
Assembly Of The HIV Virion 16 5.91e-02 -0.272000 1.12e-01
Synthesis of substrates in N-glycan biosythesis 61 2.32e-04 -0.272000 9.32e-04
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 7.72e-04 -0.272000 2.68e-03
Erythropoietin activates RAS 14 7.87e-02 -0.271000 1.41e-01
Deubiquitination 249 1.58e-13 -0.271000 4.68e-12
RAS processing 19 4.17e-02 -0.270000 8.41e-02
SUMOylation of intracellular receptors 27 1.52e-02 -0.270000 3.58e-02
Negative regulation of FGFR3 signaling 27 1.55e-02 -0.269000 3.64e-02
Class I MHC mediated antigen processing & presentation 354 3.32e-18 -0.269000 2.24e-16
Signaling by FGFR3 38 4.22e-03 -0.268000 1.16e-02
Leishmania infection 191 1.62e-10 -0.268000 3.04e-09
Rap1 signalling 15 7.29e-02 -0.267000 1.33e-01
Long-term potentiation 21 3.39e-02 -0.267000 7.05e-02
Crosslinking of collagen fibrils 10 1.43e-01 0.267000 2.31e-01
Signaling by ERBB2 ECD mutants 16 6.43e-02 -0.267000 1.20e-01
Integration of energy metabolism 96 6.05e-06 -0.267000 3.75e-05
Signaling by Receptor Tyrosine Kinases 481 8.43e-24 -0.267000 7.35e-22
Dectin-2 family 18 5.00e-02 0.267000 9.81e-02
TICAM1, RIP1-mediated IKK complex recruitment 18 5.07e-02 -0.266000 9.92e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 1.87e-04 -0.266000 7.86e-04
PECAM1 interactions 11 1.27e-01 -0.265000 2.11e-01
Metabolism of Angiotensinogen to Angiotensins 12 1.11e-01 0.265000 1.89e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 4.03e-02 -0.265000 8.19e-02
HDR through Homologous Recombination (HRR) 66 2.02e-04 0.264000 8.43e-04
DAP12 interactions 33 8.59e-03 -0.264000 2.15e-02
Glucose metabolism 83 3.13e-05 -0.264000 1.61e-04
InlB-mediated entry of Listeria monocytogenes into host cell 15 7.67e-02 -0.264000 1.39e-01
IRAK1 recruits IKK complex 10 1.49e-01 -0.264000 2.38e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 1.49e-01 -0.264000 2.38e-01
Uptake and actions of bacterial toxins 28 1.60e-02 -0.263000 3.71e-02
Constitutive Signaling by EGFRvIII 15 7.79e-02 -0.263000 1.40e-01
Signaling by EGFRvIII in Cancer 15 7.79e-02 -0.263000 1.40e-01
Interferon Signaling 175 2.02e-09 -0.262000 2.85e-08
Signaling by high-kinase activity BRAF mutants 31 1.14e-02 -0.262000 2.75e-02
Energy dependent regulation of mTOR by LKB1-AMPK 28 1.65e-02 -0.262000 3.81e-02
Alpha-protein kinase 1 signaling pathway 11 1.35e-01 -0.260000 2.20e-01
SUMOylation 170 5.34e-09 -0.259000 6.54e-08
Costimulation by the CD28 family 59 5.80e-04 -0.259000 2.13e-03
Diseases associated with glycosaminoglycan metabolism 36 7.33e-03 -0.258000 1.87e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 26 2.29e-02 -0.258000 5.06e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.34e-03 -0.257000 4.29e-03
Nuclear Receptor transcription pathway 46 2.56e-03 -0.257000 7.50e-03
SARS-CoV-1 Infection 50 1.69e-03 -0.257000 5.28e-03
RNA Polymerase II Pre-transcription Events 80 7.21e-05 -0.257000 3.35e-04
Platelet Adhesion to exposed collagen 10 1.60e-01 -0.257000 2.53e-01
FCERI mediated MAPK activation 29 1.68e-02 -0.256000 3.87e-02
Ub-specific processing proteases 177 3.90e-09 -0.256000 5.15e-08
Thromboxane signalling through TP receptor 21 4.22e-02 -0.256000 8.47e-02
Signaling by WNT 281 1.47e-13 -0.256000 4.44e-12
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 27 2.15e-02 -0.256000 4.80e-02
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.05e-02 0.255000 6.45e-02
Constitutive Signaling by Aberrant PI3K in Cancer 67 3.07e-04 -0.255000 1.21e-03
Collagen degradation 37 7.38e-03 -0.254000 1.87e-02
Regulation of PTEN gene transcription 61 5.87e-04 -0.254000 2.15e-03
FOXO-mediated transcription 59 7.41e-04 -0.254000 2.59e-03
Platelet calcium homeostasis 25 2.86e-02 -0.253000 6.09e-02
RHO GTPases Activate ROCKs 19 5.66e-02 -0.253000 1.08e-01
Budding and maturation of HIV virion 28 2.08e-02 -0.252000 4.68e-02
Transcriptional Regulation by MECP2 56 1.09e-03 -0.252000 3.64e-03
Presynaptic depolarization and calcium channel opening 11 1.48e-01 0.252000 2.37e-01
Aspartate and asparagine metabolism 10 1.68e-01 0.252000 2.62e-01
Endogenous sterols 21 4.58e-02 -0.252000 9.12e-02
Death Receptor Signalling 138 3.51e-07 -0.251000 2.85e-06
Post-translational protein modification 1277 6.02e-52 -0.251000 2.23e-49
Fatty acyl-CoA biosynthesis 34 1.14e-02 -0.251000 2.75e-02
SUMO E3 ligases SUMOylate target proteins 164 3.08e-08 -0.250000 3.12e-07
Signaling by FGFR1 48 2.71e-03 -0.250000 7.89e-03
Cellular response to starvation 150 1.31e-07 0.249000 1.21e-06
ADP signalling through P2Y purinoceptor 12 17 7.51e-02 -0.249000 1.36e-01
Signaling by NTRK2 (TRKB) 24 3.49e-02 -0.249000 7.26e-02
Formation of RNA Pol II elongation complex 57 1.17e-03 -0.249000 3.82e-03
RNA Polymerase II Transcription Elongation 57 1.17e-03 -0.249000 3.82e-03
G beta:gamma signalling through CDC42 17 7.66e-02 -0.248000 1.39e-01
Acetylcholine regulates insulin secretion 10 1.74e-01 -0.248000 2.69e-01
Inositol phosphate metabolism 46 3.66e-03 -0.248000 1.02e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 8.64e-02 -0.248000 1.53e-01
Activation of ATR in response to replication stress 37 9.25e-03 0.247000 2.29e-02
Metabolism of nitric oxide: NOS3 activation and regulation 15 9.75e-02 -0.247000 1.69e-01
Mitochondrial tRNA aminoacylation 21 5.02e-02 -0.247000 9.85e-02
Signal Transduction 2187 8.01e-82 -0.246000 1.19e-78
TNF signaling 44 4.77e-03 -0.246000 1.28e-02
Activation of BH3-only proteins 29 2.21e-02 -0.245000 4.92e-02
Signaling by Nuclear Receptors 243 4.22e-11 -0.245000 8.32e-10
Defective B3GAT3 causes JDSSDHD 19 6.48e-02 -0.245000 1.21e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 6.50e-02 -0.245000 1.21e-01
Apoptotic execution phase 48 3.39e-03 -0.244000 9.51e-03
Sodium/Calcium exchangers 11 1.62e-01 -0.244000 2.55e-01
PI-3K cascade:FGFR1 19 6.60e-02 -0.244000 1.22e-01
Dermatan sulfate biosynthesis 11 1.63e-01 -0.243000 2.56e-01
Interleukin receptor SHC signaling 21 5.44e-02 -0.242000 1.05e-01
Transcription of the HIV genome 69 4.97e-04 -0.242000 1.84e-03
Signaling by ERBB2 in Cancer 26 3.26e-02 -0.242000 6.81e-02
Estrogen-dependent gene expression 110 1.19e-05 -0.242000 6.71e-05
Sema4D in semaphorin signaling 24 4.05e-02 -0.242000 8.23e-02
Influenza Viral RNA Transcription and Replication 134 1.36e-06 0.241000 9.66e-06
MAPK family signaling cascades 299 6.68e-13 -0.241000 1.80e-11
Synthesis of PA 33 1.65e-02 -0.241000 3.80e-02
GRB2 events in ERBB2 signaling 16 9.50e-02 -0.241000 1.66e-01
Viral Messenger RNA Synthesis 44 5.70e-03 -0.241000 1.50e-02
MHC class II antigen presentation 99 3.44e-05 -0.241000 1.74e-04
Defects in cobalamin (B12) metabolism 13 1.34e-01 -0.240000 2.18e-01
Defects in vitamin and cofactor metabolism 21 5.76e-02 -0.239000 1.10e-01
HCMV Late Events 78 2.61e-04 -0.239000 1.03e-03
Neurexins and neuroligins 50 3.45e-03 -0.239000 9.64e-03
Activation of Ca-permeable Kainate Receptor 10 1.92e-01 -0.238000 2.87e-01
Ionotropic activity of kainate receptors 10 1.92e-01 -0.238000 2.87e-01
Metabolism of cofactors 19 7.19e-02 0.238000 1.32e-01
p75NTR recruits signalling complexes 13 1.37e-01 -0.238000 2.22e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 9.90e-02 -0.238000 1.72e-01
SLC transporter disorders 81 2.18e-04 -0.238000 8.90e-04
NF-kB is activated and signals survival 13 1.38e-01 -0.237000 2.24e-01
SHC1 events in ERBB2 signaling 22 5.40e-02 -0.237000 1.04e-01
Scavenging by Class A Receptors 17 9.23e-02 0.236000 1.62e-01
Formation of the ternary complex, and subsequently, the 43S complex 50 3.92e-03 0.236000 1.08e-02
EPH-ephrin mediated repulsion of cells 48 4.74e-03 -0.236000 1.28e-02
Platelet activation, signaling and aggregation 226 1.08e-09 -0.235000 1.63e-08
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 51 3.77e-03 -0.234000 1.04e-02
Mitotic Prophase 104 3.74e-05 -0.234000 1.88e-04
mTORC1-mediated signalling 24 4.75e-02 -0.234000 9.37e-02
Adaptive Immune System 651 1.94e-24 -0.234000 1.79e-22
Regulation of TP53 Activity 155 5.14e-07 -0.234000 3.92e-06
Cell recruitment (pro-inflammatory response) 23 5.25e-02 -0.233000 1.02e-01
Purinergic signaling in leishmaniasis infection 23 5.25e-02 -0.233000 1.02e-01
HATs acetylate histones 101 5.07e-05 -0.233000 2.44e-04
Cellular hexose transport 17 9.68e-02 0.233000 1.69e-01
Acetylcholine binding and downstream events 10 2.03e-01 0.232000 3.00e-01
Postsynaptic nicotinic acetylcholine receptors 10 2.03e-01 0.232000 3.00e-01
Metabolism of fat-soluble vitamins 36 1.58e-02 -0.232000 3.68e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 2.40e-03 -0.232000 7.14e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 2.40e-03 -0.232000 7.14e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 2.40e-03 -0.232000 7.14e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 2.40e-03 -0.232000 7.14e-03
Signaling by NOTCH1 in Cancer 57 2.40e-03 -0.232000 7.14e-03
Nuclear Envelope (NE) Reassembly 73 6.15e-04 -0.232000 2.23e-03
Metabolism of steroids 136 3.19e-06 -0.231000 2.11e-05
Condensation of Prometaphase Chromosomes 11 1.84e-01 0.231000 2.78e-01
Purine catabolism 17 9.93e-02 0.231000 1.72e-01
Cytosolic iron-sulfur cluster assembly 13 1.52e-01 0.229000 2.43e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 35 1.88e-02 -0.229000 4.29e-02
Maturation of nucleoprotein 11 1.88e-01 -0.229000 2.83e-01
p75 NTR receptor-mediated signalling 95 1.14e-04 -0.229000 5.08e-04
PINK1-PRKN Mediated Mitophagy 21 7.01e-02 -0.228000 1.28e-01
HIV Infection 222 4.56e-09 -0.228000 5.77e-08
SLBP independent Processing of Histone Pre-mRNAs 10 2.14e-01 0.227000 3.13e-01
Vasopressin regulates renal water homeostasis via Aquaporins 36 1.84e-02 -0.227000 4.21e-02
Glutamate Neurotransmitter Release Cycle 23 6.02e-02 -0.226000 1.14e-01
Fc epsilon receptor (FCERI) signaling 127 1.05e-05 -0.226000 6.09e-05
Regulation of TLR by endogenous ligand 15 1.29e-01 0.226000 2.13e-01
RHO GTPases activate PAKs 21 7.28e-02 -0.226000 1.33e-01
Interleukin-6 family signaling 23 6.06e-02 -0.226000 1.15e-01
Phase 2 - plateau phase 13 1.59e-01 0.226000 2.51e-01
Insulin receptor signalling cascade 50 5.87e-03 -0.225000 1.54e-02
MET activates RAS signaling 11 1.96e-01 -0.225000 2.92e-01
Intrinsic Pathway for Apoptosis 53 4.71e-03 -0.224000 1.28e-02
Formation of tubulin folding intermediates by CCT/TriC 23 6.27e-02 -0.224000 1.18e-01
PI-3K cascade:FGFR3 16 1.21e-01 -0.224000 2.01e-01
Polo-like kinase mediated events 16 1.21e-01 0.224000 2.02e-01
DAP12 signaling 26 4.84e-02 -0.224000 9.54e-02
RHO GTPase Effectors 257 6.45e-10 -0.224000 1.01e-08
Gap-filling DNA repair synthesis and ligation in GG-NER 25 5.38e-02 0.223000 1.04e-01
Pexophagy 11 2.01e-01 -0.223000 2.98e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 4.96e-02 0.222000 9.76e-02
Negative regulation of FGFR4 signaling 28 4.17e-02 -0.222000 8.41e-02
Interleukin-2 family signaling 34 2.48e-02 -0.222000 5.39e-02
LDL clearance 16 1.24e-01 -0.222000 2.06e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.68e-01 -0.221000 2.61e-01
TCF dependent signaling in response to WNT 188 1.73e-07 -0.221000 1.50e-06
PI3K Cascade 41 1.45e-02 -0.221000 3.44e-02
MAPK1/MAPK3 signaling 260 9.38e-10 -0.220000 1.43e-08
G-protein beta:gamma signalling 29 4.03e-02 -0.220000 8.19e-02
Glycosaminoglycan metabolism 111 6.24e-05 -0.220000 2.95e-04
Neurotoxicity of clostridium toxins 10 2.31e-01 0.219000 3.32e-01
Signaling by FGFR4 38 1.97e-02 -0.219000 4.46e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 76 9.91e-04 -0.218000 3.31e-03
Regulation of innate immune responses to cytosolic DNA 14 1.58e-01 -0.218000 2.50e-01
RHO GTPases activate PKNs 53 6.08e-03 -0.218000 1.59e-02
RNA Polymerase III Abortive And Retractive Initiation 41 1.60e-02 -0.217000 3.71e-02
RNA Polymerase III Transcription 41 1.60e-02 -0.217000 3.71e-02
Surfactant metabolism 19 1.01e-01 -0.217000 1.75e-01
RAF/MAP kinase cascade 254 2.53e-09 -0.217000 3.41e-08
Caspase-mediated cleavage of cytoskeletal proteins 12 1.93e-01 -0.217000 2.88e-01
Oncogene Induced Senescence 31 3.66e-02 -0.217000 7.57e-02
Transcriptional regulation by RUNX3 94 2.81e-04 -0.217000 1.11e-03
Elevation of cytosolic Ca2+ levels 13 1.76e-01 -0.217000 2.70e-01
Josephin domain DUBs 10 2.36e-01 -0.216000 3.38e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 9.40e-02 -0.216000 1.64e-01
Neurodegenerative Diseases 20 9.40e-02 -0.216000 1.64e-01
DNA Double Strand Break Response 52 7.12e-03 -0.216000 1.82e-02
WNT5A-dependent internalization of FZD4 15 1.48e-01 -0.215000 2.38e-01
Platelet homeostasis 74 1.41e-03 -0.215000 4.46e-03
Signaling by ERBB2 KD Mutants 25 6.41e-02 -0.214000 1.20e-01
Repression of WNT target genes 14 1.66e-01 -0.214000 2.59e-01
Interleukin-12 family signaling 51 8.29e-03 -0.214000 2.09e-02
Degradation of cysteine and homocysteine 11 2.22e-01 0.213000 3.22e-01
Adherens junctions interactions 28 5.24e-02 -0.212000 1.02e-01
Sphingolipid metabolism 84 7.90e-04 -0.212000 2.72e-03
ZBP1(DAI) mediated induction of type I IFNs 19 1.10e-01 -0.212000 1.88e-01
FGFR4 ligand binding and activation 11 2.24e-01 0.212000 3.25e-01
Activated NTRK2 signals through FRS2 and FRS3 11 2.24e-01 -0.212000 3.25e-01
PTEN Regulation 140 1.55e-05 -0.211000 8.50e-05
Aquaporin-mediated transport 38 2.48e-02 -0.210000 5.38e-02
Retinoid metabolism and transport 32 3.95e-02 -0.210000 8.09e-02
Interferon gamma signaling 81 1.17e-03 -0.209000 3.82e-03
Glycogen synthesis 15 1.62e-01 -0.208000 2.56e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 35 3.35e-02 -0.208000 6.97e-02
Beta-catenin independent WNT signaling 141 2.08e-05 -0.207000 1.11e-04
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 1.28e-01 -0.207000 2.12e-01
Formation of the beta-catenin:TCF transactivating complex 53 9.13e-03 -0.207000 2.26e-02
Response of Mtb to phagocytosis 22 9.38e-02 -0.206000 1.64e-01
CLEC7A (Dectin-1) signaling 97 4.52e-04 -0.206000 1.72e-03
MAP2K and MAPK activation 35 3.54e-02 -0.205000 7.35e-02
Synthesis of DNA 118 1.16e-04 0.205000 5.14e-04
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.49e-02 -0.205000 1.21e-01
Degradation of the extracellular matrix 97 4.98e-04 -0.204000 1.84e-03
Metabolism of carbohydrates 265 9.93e-09 -0.204000 1.09e-07
Neurotransmitter release cycle 47 1.55e-02 -0.204000 3.62e-02
Digestion and absorption 10 2.64e-01 0.204000 3.69e-01
A tetrasaccharide linker sequence is required for GAG synthesis 25 7.78e-02 -0.204000 1.40e-01
NOD1/2 Signaling Pathway 32 4.62e-02 -0.204000 9.18e-02
Mitochondrial biogenesis 91 8.07e-04 -0.203000 2.77e-03
Gene expression (Transcription) 1382 7.26e-37 -0.202000 1.79e-34
Transport of bile salts and organic acids, metal ions and amine compounds 61 6.40e-03 -0.202000 1.66e-02
IRS-mediated signalling 45 1.92e-02 -0.202000 4.36e-02
MyD88 deficiency (TLR2/4) 15 1.77e-01 0.201000 2.70e-01
Norepinephrine Neurotransmitter Release Cycle 16 1.63e-01 -0.201000 2.56e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 8.15e-02 -0.201000 1.45e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.93e-01 -0.201000 2.88e-01
Immune System 1660 7.39e-43 -0.201000 2.19e-40
G-protein activation 19 1.30e-01 -0.201000 2.14e-01
Cytokine Signaling in Immune system 609 3.20e-17 -0.200000 1.72e-15
NRAGE signals death through JNK 59 7.99e-03 -0.200000 2.02e-02
Formation of HIV elongation complex in the absence of HIV Tat 44 2.24e-02 -0.199000 4.97e-02
Neddylation 222 3.35e-07 -0.199000 2.74e-06
Transport of vitamins, nucleosides, and related molecules 35 4.21e-02 -0.198000 8.47e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 16 1.70e-01 -0.198000 2.64e-01
Serotonin Neurotransmitter Release Cycle 17 1.58e-01 -0.198000 2.51e-01
RIP-mediated NFkB activation via ZBP1 16 1.73e-01 -0.197000 2.66e-01
G alpha (q) signalling events 156 2.25e-05 -0.197000 1.19e-04
Binding and Uptake of Ligands by Scavenger Receptors 32 5.49e-02 0.196000 1.06e-01
CDC6 association with the ORC:origin complex 11 2.61e-01 0.196000 3.66e-01
Depolymerisation of the Nuclear Lamina 15 1.91e-01 -0.195000 2.86e-01
Gene Silencing by RNA 97 8.93e-04 -0.195000 3.03e-03
Hemostasis 496 1.15e-13 -0.194000 3.62e-12
Detoxification of Reactive Oxygen Species 31 6.29e-02 0.193000 1.18e-01
Phospholipase C-mediated cascade; FGFR4 12 2.49e-01 0.192000 3.52e-01
RNA Polymerase III Transcription Initiation 36 4.63e-02 -0.192000 9.18e-02
Synthesis of bile acids and bile salts 28 7.88e-02 -0.192000 1.41e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 7.92e-02 -0.192000 1.42e-01
Generic Transcription Pathway 1129 1.00e-27 -0.192000 1.06e-25
DNA Damage/Telomere Stress Induced Senescence 52 1.69e-02 -0.191000 3.88e-02
Activated point mutants of FGFR2 14 2.15e-01 0.191000 3.14e-01
Phosphorylation of the APC/C 20 1.41e-01 0.190000 2.28e-01
Interleukin-12 signaling 43 3.15e-02 -0.190000 6.63e-02
Negative regulation of FGFR2 signaling 31 6.77e-02 -0.190000 1.25e-01
Metabolism of lipids 657 9.65e-17 -0.189000 4.93e-15
Infection with Mycobacterium tuberculosis 24 1.08e-01 -0.189000 1.85e-01
HIV elongation arrest and recovery 32 6.36e-02 -0.189000 1.19e-01
Pausing and recovery of HIV elongation 32 6.36e-02 -0.189000 1.19e-01
rRNA processing 214 1.83e-06 0.189000 1.26e-05
Formation of apoptosome 11 2.78e-01 -0.189000 3.84e-01
Regulation of the apoptosome activity 11 2.78e-01 -0.189000 3.84e-01
Translesion synthesis by POLI 17 1.78e-01 0.189000 2.70e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.93e-01 -0.188000 2.88e-01
FGFR2c ligand binding and activation 10 3.04e-01 0.188000 4.10e-01
Homologous DNA Pairing and Strand Exchange 42 3.62e-02 0.187000 7.49e-02
Initial triggering of complement 14 2.27e-01 0.187000 3.28e-01
ECM proteoglycans 47 2.69e-02 -0.186000 5.76e-02
Defective Intrinsic Pathway for Apoptosis 22 1.30e-01 -0.186000 2.14e-01
Signaling by Interleukins 391 2.73e-10 -0.186000 5.00e-09
RNA Polymerase II Transcription 1247 1.62e-28 -0.185000 1.84e-26
Regulation of insulin secretion 67 8.75e-03 -0.185000 2.18e-02
Lysosome Vesicle Biogenesis 34 6.25e-02 -0.185000 1.18e-01
SUMOylation of transcription factors 19 1.64e-01 -0.184000 2.58e-01
Chaperonin-mediated protein folding 84 3.50e-03 -0.184000 9.75e-03
IRS-related events triggered by IGF1R 48 2.76e-02 -0.184000 5.90e-02
Formation of Incision Complex in GG-NER 43 3.73e-02 -0.183000 7.70e-02
Pyrimidine salvage 10 3.17e-01 0.183000 4.23e-01
Negative regulation of FLT3 14 2.37e-01 -0.182000 3.38e-01
Transcription of E2F targets under negative control by DREAM complex 19 1.69e-01 0.182000 2.63e-01
Termination of translesion DNA synthesis 32 7.44e-02 0.182000 1.35e-01
Ion homeostasis 46 3.25e-02 -0.182000 6.80e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 31 7.93e-02 -0.182000 1.42e-01
FGFR2 ligand binding and activation 16 2.08e-01 0.182000 3.06e-01
DNA Replication 151 1.14e-04 0.182000 5.08e-04
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 4.17e-02 -0.182000 8.41e-02
HIV Transcription Elongation 42 4.17e-02 -0.182000 8.41e-02
Tat-mediated elongation of the HIV-1 transcript 42 4.17e-02 -0.182000 8.41e-02
Infectious disease 740 3.26e-17 -0.182000 1.72e-15
Phosphorylation of CD3 and TCR zeta chains 17 1.95e-01 0.181000 2.91e-01
Mucopolysaccharidoses 11 3.00e-01 0.181000 4.05e-01
Metabolism of non-coding RNA 53 2.34e-02 -0.180000 5.15e-02
snRNP Assembly 53 2.34e-02 -0.180000 5.15e-02
Phenylalanine and tyrosine metabolism 10 3.25e-01 0.180000 4.31e-01
HDACs deacetylate histones 54 2.24e-02 -0.180000 4.97e-02
Downregulation of ERBB2:ERBB3 signaling 13 2.65e-01 -0.179000 3.70e-01
Class I peroxisomal membrane protein import 19 1.80e-01 -0.178000 2.73e-01
Constitutive Signaling by Overexpressed ERBB2 11 3.09e-01 -0.177000 4.16e-01
Phospholipase C-mediated cascade; FGFR2 15 2.35e-01 0.177000 3.38e-01
Beta-oxidation of very long chain fatty acids 10 3.33e-01 0.177000 4.38e-01
Degradation of beta-catenin by the destruction complex 83 5.43e-03 -0.176000 1.44e-02
Signaling by FGFR 83 5.45e-03 -0.176000 1.44e-02
Kinesins 41 5.10e-02 -0.176000 9.97e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.40e-01 -0.175000 3.41e-01
Disease 1458 1.89e-29 -0.175000 2.54e-27
Presynaptic phase of homologous DNA pairing and strand exchange 39 5.88e-02 0.175000 1.12e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.30e-01 0.175000 2.14e-01
Triglyceride metabolism 28 1.10e-01 -0.175000 1.87e-01
Translesion synthesis by REV1 16 2.28e-01 0.174000 3.29e-01
G beta:gamma signalling through PI3Kgamma 22 1.59e-01 -0.173000 2.52e-01
Glutamate and glutamine metabolism 13 2.79e-01 -0.173000 3.85e-01
Interferon alpha/beta signaling 57 2.42e-02 -0.173000 5.28e-02
Intraflagellar transport 39 6.22e-02 0.173000 1.18e-01
Acyl chain remodelling of PG 13 2.82e-01 -0.172000 3.89e-01
Factors involved in megakaryocyte development and platelet production 118 1.23e-03 -0.172000 3.98e-03
Anti-inflammatory response favouring Leishmania parasite infection 109 1.90e-03 -0.172000 5.85e-03
Leishmania parasite growth and survival 109 1.90e-03 -0.172000 5.85e-03
Activation of kainate receptors upon glutamate binding 27 1.23e-01 -0.172000 2.04e-01
Influenza Infection 153 2.48e-04 0.172000 9.95e-04
Signaling by the B Cell Receptor (BCR) 105 2.52e-03 -0.171000 7.43e-03
Glyoxylate metabolism and glycine degradation 26 1.33e-01 -0.170000 2.18e-01
IRAK4 deficiency (TLR2/4) 16 2.39e-01 0.170000 3.40e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 28 1.20e-01 -0.170000 2.00e-01
Trafficking of AMPA receptors 28 1.20e-01 -0.170000 2.00e-01
Disorders of Developmental Biology 13 2.89e-01 -0.170000 3.94e-01
Disorders of Nervous System Development 13 2.89e-01 -0.170000 3.94e-01
Loss of function of MECP2 in Rett syndrome 13 2.89e-01 -0.170000 3.94e-01
Pervasive developmental disorders 13 2.89e-01 -0.170000 3.94e-01
Pre-NOTCH Expression and Processing 71 1.34e-02 -0.170000 3.19e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 3.53e-01 -0.169000 4.56e-01
Synthesis of IP2, IP, and Ins in the cytosol 14 2.73e-01 -0.169000 3.78e-01
rRNA modification in the nucleus and cytosol 60 2.34e-02 -0.169000 5.15e-02
Innate Immune System 868 2.15e-17 -0.169000 1.33e-15
Host Interactions of HIV factors 124 1.15e-03 -0.169000 3.80e-03
Glycerophospholipid biosynthesis 114 1.83e-03 -0.169000 5.66e-03
Resolution of Abasic Sites (AP sites) 38 7.17e-02 0.169000 1.31e-01
Heparan sulfate/heparin (HS-GAG) metabolism 50 3.93e-02 -0.168000 8.06e-02
IGF1R signaling cascade 49 4.18e-02 -0.168000 8.42e-02
The phototransduction cascade 27 1.31e-01 -0.168000 2.14e-01
Signaling by FGFR in disease 60 2.47e-02 -0.168000 5.38e-02
ATF6 (ATF6-alpha) activates chaperones 12 3.15e-01 -0.167000 4.22e-01
Telomere C-strand (Lagging Strand) Synthesis 34 9.13e-02 0.167000 1.61e-01
RNA Polymerase III Transcription Termination 23 1.65e-01 -0.167000 2.59e-01
ABC transporters in lipid homeostasis 15 2.62e-01 0.167000 3.67e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.11e-04 0.167000 4.95e-04
Metabolism of proteins 1750 2.23e-31 -0.166000 3.67e-29
Apoptotic factor-mediated response 19 2.11e-01 -0.166000 3.09e-01
DSCAM interactions 10 3.64e-01 -0.166000 4.67e-01
Mitochondrial calcium ion transport 22 1.79e-01 -0.165000 2.72e-01
Interleukin-1 family signaling 130 1.12e-03 -0.165000 3.71e-03
Synthesis of IP3 and IP4 in the cytosol 25 1.53e-01 -0.165000 2.44e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 2.13e-01 -0.165000 3.12e-01
ERBB2 Activates PTK6 Signaling 13 3.03e-01 -0.165000 4.10e-01
Pausing and recovery of Tat-mediated HIV elongation 30 1.19e-01 -0.165000 1.99e-01
Tat-mediated HIV elongation arrest and recovery 30 1.19e-01 -0.165000 1.99e-01
Antimicrobial peptides 27 1.39e-01 0.164000 2.25e-01
Interleukin-1 signaling 97 5.13e-03 -0.164000 1.37e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.32e-01 -0.164000 2.16e-01
Activation of SMO 18 2.28e-01 -0.164000 3.29e-01
Cellular Senescence 153 4.56e-04 -0.164000 1.72e-03
Neurotransmitter receptors and postsynaptic signal transmission 158 3.71e-04 -0.164000 1.45e-03
Transcriptional regulation by small RNAs 69 1.88e-02 -0.163000 4.29e-02
Hyaluronan uptake and degradation 10 3.71e-01 0.163000 4.73e-01
Downregulation of ERBB2 signaling 29 1.30e-01 -0.162000 2.14e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 3.51e-01 0.162000 4.53e-01
Deactivation of the beta-catenin transactivating complex 41 7.34e-02 -0.162000 1.33e-01
mRNA Splicing - Minor Pathway 52 4.42e-02 0.161000 8.83e-02
Cell death signalling via NRAGE, NRIF and NADE 76 1.51e-02 -0.161000 3.56e-02
Activated NOTCH1 Transmits Signal to the Nucleus 30 1.28e-01 -0.160000 2.12e-01
PCP/CE pathway 90 8.56e-03 -0.160000 2.14e-02
Sensory processing of sound by outer hair cells of the cochlea 44 6.63e-02 -0.160000 1.23e-01
Tight junction interactions 23 1.85e-01 -0.160000 2.78e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 24 1.77e-01 0.159000 2.70e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 24 1.77e-01 0.159000 2.70e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 1.77e-01 0.159000 2.70e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 1.77e-01 0.159000 2.70e-01
Diseases of DNA Double-Strand Break Repair 24 1.77e-01 0.159000 2.70e-01
Regulation of TNFR1 signaling 35 1.04e-01 -0.159000 1.79e-01
Transcriptional Regulation by TP53 356 2.69e-07 -0.158000 2.23e-06
Apoptosis 170 3.75e-04 -0.158000 1.46e-03
Ion transport by P-type ATPases 48 5.83e-02 -0.158000 1.11e-01
Response of EIF2AK1 (HRI) to heme deficiency 15 2.91e-01 -0.157000 3.95e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 1.07e-01 0.157000 1.84e-01
Mitochondrial iron-sulfur cluster biogenesis 13 3.26e-01 0.157000 4.31e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 50 5.48e-02 -0.157000 1.05e-01
Metabolism of amino acids and derivatives 342 6.16e-07 0.157000 4.56e-06
Epigenetic regulation of gene expression 110 4.67e-03 -0.156000 1.27e-02
tRNA processing in the nucleus 59 3.92e-02 -0.155000 8.04e-02
Signaling by ERBB4 53 5.12e-02 -0.155000 1.00e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 1.72e-01 -0.155000 2.66e-01
Activation of GABAB receptors 37 1.04e-01 -0.155000 1.79e-01
GABA B receptor activation 37 1.04e-01 -0.155000 1.79e-01
Signaling by NOTCH 194 2.25e-04 -0.154000 9.11e-04
Programmed Cell Death 196 2.11e-04 -0.153000 8.68e-04
Sema4D induced cell migration and growth-cone collapse 20 2.36e-01 -0.153000 3.38e-01
Packaging Of Telomere Ends 25 1.85e-01 -0.153000 2.79e-01
Presynaptic function of Kainate receptors 18 2.62e-01 -0.153000 3.66e-01
Interleukin-4 and Interleukin-13 signaling 97 9.40e-03 -0.153000 2.31e-02
G0 and Early G1 27 1.70e-01 0.152000 2.64e-01
E2F mediated regulation of DNA replication 22 2.16e-01 0.152000 3.15e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 2.51e-01 -0.152000 3.53e-01
ADORA2B mediated anti-inflammatory cytokines production 84 1.62e-02 -0.152000 3.74e-02
Synthesis, secretion, and deacylation of Ghrelin 13 3.44e-01 0.152000 4.48e-01
rRNA processing in the nucleus and cytosol 190 3.23e-04 0.151000 1.27e-03
Cell surface interactions at the vascular wall 103 8.22e-03 -0.151000 2.07e-02
C-type lectin receptors (CLRs) 128 3.26e-03 -0.150000 9.25e-03
RHO GTPases Activate Formins 118 4.80e-03 -0.150000 1.29e-02
Visual phototransduction 74 2.56e-02 -0.150000 5.53e-02
PI-3K cascade:FGFR4 17 2.85e-01 -0.150000 3.91e-01
Diseases of carbohydrate metabolism 29 1.63e-01 0.150000 2.56e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 1.32e-01 -0.149000 2.15e-01
Cell-cell junction organization 53 6.23e-02 -0.148000 1.18e-01
G alpha (12/13) signalling events 76 2.64e-02 -0.147000 5.67e-02
PD-1 signaling 18 2.79e-01 0.147000 3.85e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 2.67e-01 -0.147000 3.72e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 2.67e-01 -0.147000 3.72e-01
Interleukin-37 signaling 21 2.44e-01 -0.147000 3.46e-01
Extension of Telomeres 51 7.00e-02 0.147000 1.28e-01
Extracellular matrix organization 261 4.53e-05 -0.146000 2.21e-04
Translation 293 1.57e-05 0.146000 8.59e-05
Downstream signaling of activated FGFR3 23 2.25e-01 -0.146000 3.25e-01
Assembly of active LPL and LIPC lipase complexes 14 3.44e-01 -0.146000 4.47e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 3.45e-01 -0.146000 4.48e-01
Regulation of FZD by ubiquitination 21 2.50e-01 -0.145000 3.52e-01
Pyruvate metabolism 28 1.84e-01 -0.145000 2.78e-01
Downstream signaling of activated FGFR1 29 1.77e-01 -0.145000 2.70e-01
RHO GTPases Activate NADPH Oxidases 22 2.41e-01 -0.144000 3.41e-01
Developmental Biology 864 5.07e-13 -0.144000 1.42e-11
Activation of HOX genes during differentiation 82 2.40e-02 -0.144000 5.24e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 82 2.40e-02 -0.144000 5.24e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 3.69e-01 0.144000 4.72e-01
IKK complex recruitment mediated by RIP1 22 2.44e-01 -0.143000 3.45e-01
RIPK1-mediated regulated necrosis 27 1.97e-01 -0.143000 2.92e-01
Regulation of necroptotic cell death 27 1.97e-01 -0.143000 2.92e-01
Sulfur amino acid metabolism 25 2.15e-01 0.143000 3.14e-01
GRB2 events in EGFR signaling 13 3.72e-01 -0.143000 4.74e-01
Transcriptional regulation by RUNX2 116 7.85e-03 -0.143000 1.99e-02
Polymerase switching on the C-strand of the telomere 26 2.07e-01 0.143000 3.05e-01
NCAM signaling for neurite out-growth 56 6.62e-02 -0.142000 1.23e-01
Signaling by FGFR3 in disease 20 2.74e-01 -0.141000 3.80e-01
Signaling by FGFR3 point mutants in cancer 20 2.74e-01 -0.141000 3.80e-01
SUMOylation of DNA methylation proteins 16 3.29e-01 -0.141000 4.35e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.19e-01 0.141000 5.21e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 3.30e-01 0.141000 4.35e-01
Transport of Mature Transcript to Cytoplasm 81 2.88e-02 -0.140000 6.12e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.42e-01 0.140000 5.43e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 9.23e-02 -0.140000 1.62e-01
Protein folding 90 2.15e-02 -0.140000 4.80e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 11 4.23e-01 -0.140000 5.25e-01
Disorders of transmembrane transporters 153 2.89e-03 -0.139000 8.36e-03
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.48e-01 -0.139000 3.50e-01
FGFRL1 modulation of FGFR1 signaling 12 4.04e-01 -0.139000 5.06e-01
Signaling by ERBB2 TMD/JMD mutants 22 2.61e-01 -0.139000 3.66e-01
Synthesis of PE 13 3.89e-01 -0.138000 4.90e-01
Signaling by NOTCH2 32 1.77e-01 -0.138000 2.70e-01
Formation of the Early Elongation Complex 33 1.72e-01 -0.137000 2.66e-01
Formation of the HIV-1 Early Elongation Complex 33 1.72e-01 -0.137000 2.66e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.21e-01 -0.137000 2.01e-01
Transcriptional regulation by RUNX1 187 1.30e-03 -0.136000 4.18e-03
Signaling by FGFR2 69 5.05e-02 -0.136000 9.90e-02
Late endosomal microautophagy 30 1.97e-01 -0.136000 2.92e-01
Deposition of new CENPA-containing nucleosomes at the centromere 45 1.15e-01 0.136000 1.95e-01
Nucleosome assembly 45 1.15e-01 0.136000 1.95e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 3.63e-01 0.136000 4.66e-01
Neuronal System 334 2.06e-05 -0.135000 1.10e-04
Phase 4 - resting membrane potential 16 3.48e-01 -0.135000 4.51e-01
APC-Cdc20 mediated degradation of Nek2A 26 2.33e-01 0.135000 3.35e-01
Glycogen storage diseases 14 3.82e-01 0.135000 4.84e-01
MAPK6/MAPK4 signaling 87 2.97e-02 -0.135000 6.30e-02
Ras activation upon Ca2+ influx through NMDA receptor 19 3.09e-01 -0.135000 4.16e-01
Chromosome Maintenance 110 1.52e-02 0.134000 3.58e-02
G beta:gamma signalling through BTK 15 3.70e-01 -0.134000 4.72e-01
Acetylcholine Neurotransmitter Release Cycle 15 3.75e-01 -0.132000 4.77e-01
Striated Muscle Contraction 26 2.44e-01 0.132000 3.45e-01
G beta:gamma signalling through PLC beta 17 3.46e-01 -0.132000 4.49e-01
Cyclin D associated events in G1 45 1.26e-01 -0.132000 2.08e-01
G1 Phase 45 1.26e-01 -0.132000 2.08e-01
Regulation of TP53 Activity through Association with Co-factors 12 4.29e-01 -0.132000 5.31e-01
G alpha (s) signalling events 95 2.65e-02 -0.132000 5.68e-02
Translesion synthesis by POLK 17 3.47e-01 0.132000 4.50e-01
Formation of Fibrin Clot (Clotting Cascade) 24 2.64e-01 -0.132000 3.69e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 12 4.30e-01 -0.132000 5.32e-01
HIV Transcription Initiation 47 1.19e-01 -0.132000 1.99e-01
RNA Polymerase II HIV Promoter Escape 47 1.19e-01 -0.132000 1.99e-01
RNA Polymerase II Promoter Escape 47 1.19e-01 -0.132000 1.99e-01
RNA Polymerase II Transcription Initiation 47 1.19e-01 -0.132000 1.99e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 47 1.19e-01 -0.132000 1.99e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 47 1.19e-01 -0.132000 1.99e-01
Nervous system development 527 2.29e-07 -0.131000 1.93e-06
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.41e-01 0.130000 4.45e-01
GABA receptor activation 48 1.21e-01 -0.129000 2.01e-01
FGFR3 mutant receptor activation 10 4.80e-01 0.129000 5.80e-01
Signaling by activated point mutants of FGFR3 10 4.80e-01 0.129000 5.80e-01
SLC-mediated transmembrane transport 201 1.71e-03 -0.128000 5.34e-03
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 4.07e-01 -0.128000 5.09e-01
Olfactory Signaling Pathway 20 3.22e-01 0.128000 4.28e-01
Positive epigenetic regulation of rRNA expression 68 6.87e-02 -0.128000 1.26e-01
Chondroitin sulfate biosynthesis 20 3.24e-01 -0.127000 4.29e-01
HDR through Single Strand Annealing (SSA) 37 1.80e-01 0.127000 2.73e-01
FRS-mediated FGFR1 signaling 21 3.13e-01 -0.127000 4.21e-01
mRNA Capping 29 2.36e-01 -0.127000 3.38e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 57 9.71e-02 -0.127000 1.69e-01
Platelet degranulation 110 2.13e-02 -0.127000 4.77e-02
Signaling by GPCR 484 1.63e-06 -0.127000 1.15e-05
SHC1 events in ERBB4 signaling 14 4.11e-01 -0.127000 5.12e-01
Incretin synthesis, secretion, and inactivation 17 3.66e-01 -0.127000 4.69e-01
DNA Replication Pre-Initiation 108 2.31e-02 0.126000 5.11e-02
Transmission across Chemical Synapses 219 1.29e-03 -0.126000 4.17e-03
Triglyceride catabolism 19 3.45e-01 -0.125000 4.48e-01
GPCR downstream signalling 426 1.02e-05 -0.124000 5.98e-05
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 11 4.76e-01 -0.124000 5.77e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.37e-01 0.124000 4.41e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.26e-01 0.124000 4.31e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.26e-01 0.124000 4.31e-01
Initiation of Nuclear Envelope (NE) Reformation 19 3.50e-01 -0.124000 4.53e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 105 2.90e-02 0.123000 6.16e-02
FCERI mediated NF-kB activation 75 6.50e-02 -0.123000 1.21e-01
Peptide hormone metabolism 67 8.19e-02 -0.123000 1.46e-01
Signaling by Insulin receptor 73 6.96e-02 -0.123000 1.28e-01
Homology Directed Repair 111 2.61e-02 0.122000 5.62e-02
Synthesis of very long-chain fatty acyl-CoAs 22 3.22e-01 -0.122000 4.28e-01
Transport of small molecules 607 2.82e-07 -0.122000 2.32e-06
Nucleotide salvage 21 3.35e-01 0.122000 4.39e-01
G1/S Transition 131 1.63e-02 0.122000 3.76e-02
Response to elevated platelet cytosolic Ca2+ 115 2.48e-02 -0.121000 5.38e-02
Regulation of TP53 Activity through Phosphorylation 91 4.64e-02 -0.121000 9.18e-02
RNA Polymerase I Transcription Initiation 47 1.52e-01 -0.121000 2.43e-01
Oxidative Stress Induced Senescence 83 5.77e-02 -0.120000 1.10e-01
Chondroitin sulfate/dermatan sulfate metabolism 49 1.46e-01 -0.120000 2.35e-01
ROS and RNS production in phagocytes 32 2.41e-01 0.120000 3.41e-01
Neutrophil degranulation 423 2.40e-05 -0.120000 1.25e-04
TRAF6 mediated NF-kB activation 23 3.21e-01 -0.119000 4.28e-01
Interaction between L1 and Ankyrins 26 2.92e-01 -0.119000 3.96e-01
HS-GAG degradation 20 3.56e-01 -0.119000 4.59e-01
Synthesis of PC 26 2.95e-01 -0.119000 3.99e-01
Removal of the Flap Intermediate from the C-strand 17 3.98e-01 -0.118000 4.99e-01
Signaling by ROBO receptors 211 3.16e-03 0.118000 9.05e-03
Signaling by NOTCH3 46 1.68e-01 -0.117000 2.62e-01
Diseases of DNA repair 34 2.36e-01 0.117000 3.38e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.13e-01 -0.117000 1.91e-01
Resolution of Sister Chromatid Cohesion 105 3.78e-02 -0.117000 7.78e-02
Glycogen breakdown (glycogenolysis) 15 4.35e-01 -0.116000 5.37e-01
Dissolution of Fibrin Clot 13 4.69e-01 -0.116000 5.70e-01
O-linked glycosylation of mucins 54 1.41e-01 -0.116000 2.28e-01
SHC-mediated cascade:FGFR2 20 3.71e-01 0.116000 4.73e-01
SHC-mediated cascade:FGFR4 17 4.10e-01 0.115000 5.12e-01
Phospholipase C-mediated cascade; FGFR3 11 5.08e-01 0.115000 6.05e-01
Organelle biogenesis and maintenance 272 1.06e-03 -0.115000 3.54e-03
Transport of inorganic cations/anions and amino acids/oligopeptides 92 5.61e-02 -0.115000 1.08e-01
Branched-chain amino acid catabolism 21 3.63e-01 -0.115000 4.66e-01
Sensory processing of sound by inner hair cells of the cochlea 57 1.35e-01 -0.114000 2.19e-01
Phase II - Conjugation of compounds 76 8.54e-02 0.114000 1.52e-01
Meiotic recombination 47 1.77e-01 0.114000 2.70e-01
Axon guidance 505 1.14e-05 -0.114000 6.52e-05
Interconversion of nucleotide di- and triphosphates 29 2.90e-01 0.114000 3.94e-01
Glycogen metabolism 26 3.18e-01 -0.113000 4.24e-01
Methylation 14 4.64e-01 0.113000 5.65e-01
Phase 0 - rapid depolarisation 30 2.84e-01 0.113000 3.91e-01
Regulation of beta-cell development 30 2.86e-01 -0.112000 3.93e-01
Telomere Maintenance 85 7.32e-02 0.112000 1.33e-01
Butyrophilin (BTN) family interactions 11 5.20e-01 -0.112000 6.16e-01
Signaling by CSF3 (G-CSF) 30 2.90e-01 -0.112000 3.94e-01
Metabolism of folate and pterines 16 4.39e-01 0.112000 5.41e-01
Transcriptional regulation of pluripotent stem cells 31 2.87e-01 -0.111000 3.93e-01
Signaling by EGFR in Cancer 25 3.40e-01 -0.110000 4.45e-01
Formation of TC-NER Pre-Incision Complex 53 1.66e-01 -0.110000 2.59e-01
PI-3K cascade:FGFR2 20 3.95e-01 -0.110000 4.97e-01
Peroxisomal protein import 60 1.43e-01 -0.109000 2.31e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.11e-01 -0.109000 1.89e-01
Switching of origins to a post-replicative state 89 7.68e-02 0.108000 1.39e-01
G alpha (i) signalling events 197 8.84e-03 -0.108000 2.20e-02
Cellular responses to stress 680 1.71e-06 -0.107000 1.20e-05
Signalling to RAS 20 4.07e-01 -0.107000 5.09e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.88e-01 0.107000 5.89e-01
CASP8 activity is inhibited 10 5.58e-01 -0.107000 6.48e-01
Dimerization of procaspase-8 10 5.58e-01 -0.107000 6.48e-01
Regulation by c-FLIP 10 5.58e-01 -0.107000 6.48e-01
Sensory processing of sound 62 1.46e-01 -0.107000 2.35e-01
EML4 and NUDC in mitotic spindle formation 96 7.21e-02 -0.106000 1.32e-01
Biosynthesis of DHA-derived SPMs 14 4.92e-01 0.106000 5.92e-01
Ribosomal scanning and start codon recognition 57 1.67e-01 0.106000 2.60e-01
Telomere Extension By Telomerase 23 3.80e-01 -0.106000 4.82e-01
Chemokine receptors bind chemokines 28 3.34e-01 0.105000 4.38e-01
Cytosolic sulfonation of small molecules 21 4.03e-01 -0.105000 5.06e-01
RNA Polymerase I Transcription Termination 30 3.21e-01 -0.105000 4.28e-01
Post-chaperonin tubulin folding pathway 20 4.23e-01 0.103000 5.25e-01
Fertilization 16 4.78e-01 0.103000 5.78e-01
RNA Polymerase III Chain Elongation 18 4.53e-01 -0.102000 5.54e-01
Translation initiation complex formation 57 1.82e-01 0.102000 2.75e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 4.29e-01 0.102000 5.31e-01
Amino acid transport across the plasma membrane 30 3.33e-01 -0.102000 4.38e-01
RA biosynthesis pathway 18 4.54e-01 0.102000 5.56e-01
Meiotic synapsis 50 2.15e-01 -0.101000 3.14e-01
TCR signaling 110 6.68e-02 -0.101000 1.24e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 13 5.33e-01 0.100000 6.29e-01
B-WICH complex positively regulates rRNA expression 53 2.10e-01 -0.099500 3.08e-01
Recycling of bile acids and salts 12 5.52e-01 0.099200 6.46e-01
Mitochondrial protein import 64 1.70e-01 0.099000 2.64e-01
Orc1 removal from chromatin 69 1.56e-01 0.098800 2.48e-01
Regulation of PTEN stability and activity 67 1.62e-01 -0.098700 2.56e-01
Nucleotide catabolism 31 3.42e-01 0.098600 4.46e-01
Cellular responses to stimuli 690 9.85e-06 -0.098500 5.86e-05
Insulin receptor recycling 24 4.04e-01 0.098300 5.06e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 5.10e-01 -0.098300 6.07e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 5.10e-01 -0.098300 6.07e-01
Heme biosynthesis 13 5.40e-01 0.098200 6.37e-01
Downstream signaling events of B Cell Receptor (BCR) 79 1.31e-01 -0.098100 2.15e-01
Pre-NOTCH Transcription and Translation 55 2.08e-01 -0.098100 3.06e-01
Signaling by Hedgehog 132 5.18e-02 -0.098000 1.01e-01
Eicosanoid ligand-binding receptors 13 5.41e-01 -0.097800 6.38e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 5.42e-01 -0.097600 6.38e-01
Downstream signaling of activated FGFR4 24 4.11e-01 -0.096900 5.12e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 92 1.10e-01 -0.096400 1.88e-01
Amplification of signal from the kinetochores 92 1.10e-01 -0.096400 1.88e-01
APC/C:Cdc20 mediated degradation of Securin 66 1.79e-01 0.095600 2.72e-01
Diseases associated with O-glycosylation of proteins 63 1.91e-01 0.095300 2.86e-01
Vif-mediated degradation of APOBEC3G 52 2.38e-01 0.094500 3.39e-01
Nuclear signaling by ERBB4 29 3.78e-01 -0.094500 4.81e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 5.01e-01 0.094300 6.00e-01
p38MAPK events 13 5.58e-01 -0.093900 6.48e-01
FGFR2 mutant receptor activation 30 3.74e-01 0.093700 4.77e-01
Processing of Capped Intronless Pre-mRNA 28 3.95e-01 -0.092800 4.97e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.12e-01 -0.092700 6.97e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 4.33e-01 -0.092400 5.35e-01
Common Pathway of Fibrin Clot Formation 14 5.51e-01 -0.092000 6.46e-01
Plasma lipoprotein assembly, remodeling, and clearance 58 2.26e-01 -0.091900 3.26e-01
Regulation of RUNX2 expression and activity 70 1.84e-01 -0.091800 2.78e-01
LGI-ADAM interactions 12 5.83e-01 -0.091600 6.73e-01
SHC1 events in EGFR signaling 14 5.55e-01 -0.091100 6.47e-01
Assembly of the pre-replicative complex 91 1.34e-01 0.090900 2.18e-01
FRS-mediated FGFR3 signaling 18 5.07e-01 -0.090200 6.05e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 1.82e-01 0.089800 2.75e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 2.40e-01 0.089200 3.41e-01
Mitotic Metaphase and Anaphase 229 2.01e-02 -0.089000 4.55e-02
Transferrin endocytosis and recycling 30 3.99e-01 0.088900 5.01e-01
Inactivation of CSF3 (G-CSF) signaling 25 4.44e-01 -0.088400 5.45e-01
Prostacyclin signalling through prostacyclin receptor 16 5.42e-01 -0.088100 6.38e-01
Mitotic Anaphase 228 2.20e-02 -0.088000 4.90e-02
Regulation of PLK1 Activity at G2/M Transition 87 1.58e-01 -0.087500 2.51e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 4.38e-01 -0.086200 5.39e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.38e-01 -0.086200 5.39e-01
Cleavage of the damaged pyrimidine 34 3.88e-01 -0.085600 4.89e-01
Depyrimidination 34 3.88e-01 -0.085600 4.89e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 34 3.88e-01 -0.085600 4.89e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 6.39e-01 -0.085600 7.21e-01
Regulated Necrosis 51 2.91e-01 -0.085400 3.95e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 2.41e-01 0.084700 3.42e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 6.11e-01 0.084700 6.97e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 5.83e-01 0.084600 6.73e-01
RMTs methylate histone arginines 44 3.37e-01 -0.083700 4.41e-01
MASTL Facilitates Mitotic Progression 10 6.48e-01 0.083300 7.29e-01
Negative epigenetic regulation of rRNA expression 71 2.26e-01 -0.083200 3.26e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 6.10e-01 -0.081800 6.97e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 2.30e-01 0.081700 3.32e-01
Amino acids regulate mTORC1 51 3.15e-01 -0.081300 4.22e-01
Asymmetric localization of PCP proteins 62 2.71e-01 -0.080700 3.77e-01
TRP channels 18 5.54e-01 -0.080500 6.47e-01
Stimuli-sensing channels 83 2.07e-01 -0.080100 3.05e-01
TP53 Regulates Metabolic Genes 85 2.02e-01 -0.080000 2.99e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 6.62e-01 -0.079800 7.42e-01
Dual Incision in GG-NER 41 3.77e-01 0.079800 4.79e-01
Downstream TCR signaling 90 1.91e-01 -0.079700 2.86e-01
MicroRNA (miRNA) biogenesis 24 4.99e-01 -0.079600 6.00e-01
Regulation of RAS by GAPs 64 2.71e-01 -0.079500 3.77e-01
Plasma lipoprotein assembly 13 6.22e-01 0.079000 7.06e-01
DNA methylation 27 4.82e-01 0.078100 5.82e-01
Recognition of DNA damage by PCNA-containing replication complex 30 4.60e-01 0.078000 5.62e-01
Transcriptional regulation of granulopoiesis 52 3.32e-01 -0.077800 4.37e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 29 4.68e-01 -0.077800 5.70e-01
M Phase 371 1.03e-02 -0.077500 2.51e-02
Defective CFTR causes cystic fibrosis 58 3.09e-01 -0.077200 4.16e-01
Mitotic G1 phase and G1/S transition 147 1.07e-01 0.077000 1.84e-01
CDT1 association with the CDC6:ORC:origin complex 57 3.16e-01 0.076700 4.23e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 2.52e-01 0.076500 3.54e-01
Class B/2 (Secretin family receptors) 73 2.59e-01 -0.076400 3.63e-01
Acyl chain remodelling of PS 17 5.86e-01 -0.076400 6.75e-01
Bile acid and bile salt metabolism 35 4.36e-01 -0.076000 5.38e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.12e-01 -0.075800 6.08e-01
Cytoprotection by HMOX1 119 1.56e-01 -0.075200 2.48e-01
Cellular response to hypoxia 73 2.66e-01 -0.075200 3.72e-01
Aggrephagy 21 5.52e-01 -0.075000 6.46e-01
Cardiac conduction 109 1.77e-01 -0.074900 2.70e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 5.03e-01 0.074500 6.01e-01
Loss of Nlp from mitotic centrosomes 69 2.87e-01 -0.074100 3.93e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 2.87e-01 -0.074100 3.93e-01
Hedgehog ‘off’ state 95 2.13e-01 -0.073900 3.12e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 26 5.17e-01 -0.073400 6.13e-01
Other semaphorin interactions 15 6.23e-01 -0.073300 7.07e-01
Regulation of HMOX1 expression and activity 63 3.14e-01 -0.073300 4.22e-01
Downstream signaling of activated FGFR2 27 5.10e-01 -0.073200 6.07e-01
AURKA Activation by TPX2 72 2.85e-01 -0.072900 3.92e-01
Sensory Perception 176 9.64e-02 -0.072600 1.68e-01
Metabolic disorders of biological oxidation enzymes 29 5.01e-01 0.072200 6.00e-01
Telomere C-strand synthesis initiation 13 6.53e-01 -0.072000 7.33e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 2.95e-01 0.071900 3.99e-01
RNA Polymerase II Transcription Termination 65 3.17e-01 0.071800 4.23e-01
Ion channel transport 152 1.31e-01 -0.070900 2.15e-01
O-linked glycosylation 102 2.17e-01 -0.070800 3.15e-01
Processing of SMDT1 15 6.36e-01 -0.070600 7.18e-01
CS/DS degradation 14 6.49e-01 0.070300 7.29e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 27 5.28e-01 -0.070200 6.25e-01
Cilium Assembly 181 1.04e-01 -0.070000 1.79e-01
Defective B3GALTL causes PpS 37 4.61e-01 0.070000 5.63e-01
CDK-mediated phosphorylation and removal of Cdc6 71 3.15e-01 0.069000 4.22e-01
Metalloprotease DUBs 26 5.44e-01 -0.068800 6.39e-01
Negative regulation of NOTCH4 signaling 54 3.84e-01 0.068400 4.86e-01
Nicotinate metabolism 29 5.25e-01 0.068300 6.21e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 3.22e-01 0.067500 4.28e-01
The canonical retinoid cycle in rods (twilight vision) 19 6.13e-01 0.067000 6.98e-01
Activation of NF-kappaB in B cells 65 3.51e-01 -0.066900 4.53e-01
S Phase 160 1.46e-01 0.066600 2.35e-01
Keratinization 57 3.86e-01 -0.066300 4.88e-01
NoRC negatively regulates rRNA expression 68 3.47e-01 -0.065900 4.50e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 4.95e-01 0.065800 5.95e-01
Diseases of glycosylation 133 1.95e-01 -0.065100 2.90e-01
Biological oxidations 155 1.63e-01 0.064900 2.56e-01
RNA Polymerase I Promoter Opening 25 5.75e-01 0.064800 6.65e-01
Nitric oxide stimulates guanylate cyclase 18 6.34e-01 -0.064800 7.18e-01
Generation of second messenger molecules 29 5.47e-01 0.064700 6.42e-01
Chaperone Mediated Autophagy 18 6.35e-01 -0.064600 7.18e-01
Arachidonic acid metabolism 43 4.64e-01 0.064600 5.65e-01
NCAM1 interactions 36 5.05e-01 0.064200 6.03e-01
Tryptophan catabolism 13 6.91e-01 0.063800 7.67e-01
FGFR2 alternative splicing 26 5.74e-01 -0.063700 6.65e-01
Regulation of RUNX3 expression and activity 54 4.20e-01 -0.063400 5.22e-01
Na+/Cl- dependent neurotransmitter transporters 11 7.17e-01 -0.063100 7.89e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.01e-01 0.063100 6.00e-01
TNFs bind their physiological receptors 22 6.09e-01 0.063100 6.97e-01
Hedgehog ‘on’ state 84 3.31e-01 -0.061300 4.36e-01
Trafficking of GluR2-containing AMPA receptors 16 6.74e-01 -0.060600 7.53e-01
TICAM1-dependent activation of IRF3/IRF7 12 7.17e-01 -0.060500 7.89e-01
Biotin transport and metabolism 11 7.28e-01 -0.060500 7.95e-01
Plasma lipoprotein remodeling 25 6.02e-01 -0.060300 6.90e-01
Processing of Capped Intron-Containing Pre-mRNA 238 1.10e-01 -0.060000 1.88e-01
PERK regulates gene expression 32 5.57e-01 -0.060000 6.48e-01
RNA Polymerase I Promoter Clearance 72 3.79e-01 -0.059900 4.81e-01
RNA Polymerase I Transcription 72 3.79e-01 -0.059900 4.81e-01
Other interleukin signaling 22 6.32e-01 -0.059100 7.15e-01
Transcriptional Regulation by VENTX 38 5.32e-01 -0.058500 6.29e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 83 3.58e-01 0.058400 4.60e-01
Apoptosis induced DNA fragmentation 12 7.28e-01 0.058100 7.95e-01
Voltage gated Potassium channels 33 5.65e-01 -0.057900 6.55e-01
SHC-mediated cascade:FGFR3 16 6.89e-01 0.057900 7.67e-01
HDR through MMEJ (alt-NHEJ) 10 7.53e-01 -0.057400 8.13e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 38 5.43e-01 -0.057100 6.38e-01
tRNA processing 124 2.75e-01 0.056700 3.81e-01
G2/M DNA damage checkpoint 69 4.21e-01 -0.056000 5.23e-01
Inwardly rectifying K+ channels 30 6.00e-01 0.055400 6.88e-01
Mitotic Prometaphase 186 1.94e-01 -0.055200 2.89e-01
Diseases associated with N-glycosylation of proteins 17 6.97e-01 -0.054600 7.73e-01
Protein localization 158 2.37e-01 -0.054500 3.38e-01
Nucleotide Excision Repair 110 3.26e-01 -0.054200 4.31e-01
Peptide ligand-binding receptors 106 3.36e-01 0.054000 4.40e-01
Inhibition of DNA recombination at telomere 40 5.55e-01 -0.054000 6.47e-01
Mitotic Spindle Checkpoint 109 3.33e-01 -0.053700 4.37e-01
PRC2 methylates histones and DNA 35 5.83e-01 -0.053700 6.73e-01
Cross-presentation of soluble exogenous antigens (endosomes) 45 5.55e-01 0.050900 6.47e-01
Plasma lipoprotein clearance 29 6.36e-01 -0.050700 7.18e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 6.48e-01 -0.050700 7.29e-01
Defective pyroptosis 35 6.04e-01 0.050600 6.92e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 7.19e-01 -0.050500 7.89e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 7.19e-01 -0.050500 7.89e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 7.63e-01 0.050300 8.21e-01
alpha-linolenic acid (ALA) metabolism 12 7.63e-01 0.050300 8.21e-01
Regulation of gene expression in beta cells 14 7.45e-01 -0.050300 8.09e-01
Post-translational protein phosphorylation 86 4.24e-01 -0.049900 5.25e-01
Assembly of the ORC complex at the origin of replication 31 6.31e-01 -0.049800 7.15e-01
O-glycosylation of TSR domain-containing proteins 38 5.97e-01 0.049600 6.87e-01
Diseases of programmed cell death 62 5.00e-01 -0.049500 6.00e-01
Senescence-Associated Secretory Phenotype (SASP) 72 4.74e-01 -0.048800 5.76e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 7.14e-01 -0.048500 7.89e-01
Base Excision Repair 64 5.04e-01 0.048300 6.02e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 96 4.15e-01 -0.048200 5.16e-01
Advanced glycosylation endproduct receptor signaling 11 7.83e-01 -0.048100 8.39e-01
Acyl chain remodelling of PE 22 6.99e-01 0.047700 7.74e-01
Separation of Sister Chromatids 168 2.89e-01 -0.047400 3.94e-01
FGFR1c ligand binding and activation 10 7.96e-01 -0.047300 8.51e-01
Vitamin D (calciferol) metabolism 10 7.96e-01 -0.047100 8.51e-01
UCH proteinases 92 4.41e-01 -0.046400 5.43e-01
Suppression of phagosomal maturation 13 7.75e-01 0.045900 8.32e-01
G2/M Checkpoints 140 3.52e-01 0.045500 4.54e-01
APC/C-mediated degradation of cell cycle proteins 86 4.75e-01 0.044500 5.76e-01
Regulation of mitotic cell cycle 86 4.75e-01 0.044500 5.76e-01
Amine ligand-binding receptors 22 7.18e-01 -0.044500 7.89e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 5.91e-01 0.044400 6.80e-01
Vitamin B5 (pantothenate) metabolism 17 7.54e-01 0.044000 8.13e-01
cGMP effects 14 7.81e-01 -0.042900 8.38e-01
Transcriptional Regulation by E2F6 34 6.74e-01 0.041700 7.53e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 6.11e-01 0.041600 6.97e-01
p53-Independent DNA Damage Response 50 6.11e-01 0.041600 6.97e-01
p53-Independent G1/S DNA damage checkpoint 50 6.11e-01 0.041600 6.97e-01
Acyl chain remodelling of PC 21 7.44e-01 0.041200 8.09e-01
Dectin-1 mediated noncanonical NF-kB signaling 59 5.85e-01 -0.041100 6.75e-01
Metabolism of nucleotides 90 5.01e-01 0.041000 6.00e-01
Metabolism of vitamins and cofactors 173 3.55e-01 -0.040800 4.57e-01
FGFR3 ligand binding and activation 11 8.17e-01 0.040400 8.67e-01
FGFR3c ligand binding and activation 11 8.17e-01 0.040400 8.67e-01
SCF(Skp2)-mediated degradation of p27/p21 60 5.98e-01 0.039300 6.88e-01
Cleavage of the damaged purine 29 7.16e-01 -0.039100 7.89e-01
Depurination 29 7.16e-01 -0.039100 7.89e-01
Recognition and association of DNA glycosylase with site containing an affected purine 29 7.16e-01 -0.039100 7.89e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 5.54e-01 -0.038800 6.47e-01
Mismatch Repair 15 7.96e-01 0.038500 8.51e-01
Metabolism 1885 5.44e-03 -0.038400 1.44e-02
Killing mechanisms 12 8.18e-01 -0.038400 8.67e-01
WNT5:FZD7-mediated leishmania damping 12 8.18e-01 -0.038400 8.67e-01
ABC-family proteins mediated transport 97 5.16e-01 -0.038200 6.12e-01
Diseases associated with the TLR signaling cascade 28 7.32e-01 -0.037400 7.97e-01
Diseases of Immune System 28 7.32e-01 -0.037400 7.97e-01
Base-Excision Repair, AP Site Formation 36 6.99e-01 -0.037200 7.74e-01
Xenobiotics 15 8.03e-01 -0.037200 8.56e-01
ER-Phagosome pathway 87 5.49e-01 -0.037200 6.44e-01
Signaling by Retinoic Acid 38 6.94e-01 -0.036800 7.71e-01
Ubiquitin-dependent degradation of Cyclin D 50 6.53e-01 0.036800 7.33e-01
Activation of G protein gated Potassium channels 25 7.51e-01 0.036700 8.12e-01
G protein gated Potassium channels 25 7.51e-01 0.036700 8.12e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 25 7.51e-01 0.036700 8.12e-01
Metabolism of polyamines 57 6.38e-01 -0.036100 7.19e-01
Post-translational modification: synthesis of GPI-anchored proteins 67 6.15e-01 0.035600 6.99e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 5.66e-01 -0.035500 6.56e-01
Diseases of metabolism 218 3.68e-01 -0.035300 4.71e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 6.44e-01 0.035000 7.26e-01
Muscle contraction 161 4.54e-01 -0.034200 5.56e-01
SIRT1 negatively regulates rRNA expression 30 7.52e-01 -0.033400 8.12e-01
GABA synthesis, release, reuptake and degradation 18 8.06e-01 -0.033300 8.59e-01
G2/M Transition 181 4.44e-01 -0.033000 5.44e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 6.02e-01 -0.032900 6.90e-01
Collagen formation 86 5.99e-01 -0.032800 6.88e-01
Fatty acid metabolism 152 4.86e-01 -0.032700 5.86e-01
Signaling by FGFR2 in disease 40 7.21e-01 -0.032600 7.91e-01
Regulation of APC/C activators between G1/S and early anaphase 79 6.20e-01 0.032300 7.04e-01
Regulation of BACH1 activity 11 8.54e-01 0.032100 8.99e-01
Degradation of AXIN 53 6.86e-01 -0.032100 7.65e-01
Cell Cycle, Mitotic 513 2.22e-01 -0.031500 3.22e-01
mRNA 3’-end processing 56 6.85e-01 0.031300 7.64e-01
Condensation of Prophase Chromosomes 35 7.48e-01 0.031300 8.12e-01
Metabolism of porphyrins 22 8.01e-01 0.031100 8.54e-01
FRS-mediated FGFR4 signaling 19 8.15e-01 -0.030900 8.67e-01
tRNA modification in the nucleus and cytosol 43 7.26e-01 0.030900 7.94e-01
Complement cascade 36 7.49e-01 0.030800 8.12e-01
NIK–>noncanonical NF-kB signaling 57 6.90e-01 -0.030600 7.67e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 8.61e-01 -0.030500 9.05e-01
DNA Damage Recognition in GG-NER 38 7.46e-01 -0.030400 8.10e-01
Basigin interactions 23 8.01e-01 -0.030300 8.54e-01
RNA Polymerase I Promoter Escape 53 7.05e-01 -0.030100 7.80e-01
Heme degradation 11 8.64e-01 -0.029900 9.06e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 8.64e-01 -0.029900 9.06e-01
Amyloid fiber formation 60 6.91e-01 0.029700 7.67e-01
Mitotic G2-G2/M phases 183 4.92e-01 -0.029400 5.92e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 7.13e-01 0.029200 7.89e-01
Recruitment of NuMA to mitotic centrosomes 80 6.54e-01 -0.029000 7.33e-01
FGFR1 ligand binding and activation 14 8.52e-01 -0.028800 8.98e-01
ABC transporter disorders 72 6.78e-01 -0.028300 7.57e-01
Assembly of collagen fibrils and other multimeric structures 54 7.22e-01 -0.028000 7.91e-01
Carboxyterminal post-translational modifications of tubulin 37 7.71e-01 -0.027700 8.28e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 8.45e-01 -0.027300 8.94e-01
Potassium Channels 84 6.67e-01 -0.027200 7.46e-01
Intrinsic Pathway of Fibrin Clot Formation 14 8.62e-01 -0.026900 9.06e-01
DNA Damage Bypass 47 7.50e-01 -0.026800 8.12e-01
Acyl chain remodelling of PI 12 8.72e-01 0.026800 9.11e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 7.42e-01 0.026100 8.08e-01
ROS sensing by NFE2L2 55 7.38e-01 -0.026100 8.03e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 8.37e-01 -0.025300 8.86e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 7.63e-01 0.025100 8.21e-01
GPCR ligand binding 270 4.77e-01 -0.025100 5.78e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 13 8.78e-01 0.024700 9.15e-01
DNA Repair 298 4.66e-01 -0.024500 5.68e-01
IL-6-type cytokine receptor ligand interactions 16 8.65e-01 -0.024500 9.06e-01
Diseases of mitotic cell cycle 38 7.96e-01 0.024200 8.51e-01
Cell Cycle 638 2.99e-01 -0.024000 4.04e-01
NRIF signals cell death from the nucleus 16 8.68e-01 0.023900 9.09e-01
Cellular response to chemical stress 149 6.24e-01 -0.023200 7.08e-01
Stabilization of p53 53 7.70e-01 0.023200 8.28e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 8.81e-01 -0.023100 9.18e-01
The activation of arylsulfatases 10 9.02e-01 0.022500 9.35e-01
Nucleotide-like (purinergic) receptors 10 9.03e-01 0.022300 9.35e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 8.33e-01 -0.022200 8.82e-01
Cyclin A:Cdk2-associated events at S phase entry 85 7.26e-01 -0.022000 7.94e-01
Vpu mediated degradation of CD4 50 7.88e-01 0.022000 8.45e-01
Nicotinamide salvaging 18 8.79e-01 0.020800 9.16e-01
DNA Double-Strand Break Repair 140 6.72e-01 0.020700 7.51e-01
Antigen processing-Cross presentation 98 7.24e-01 -0.020700 7.93e-01
Pyroptosis 24 8.65e-01 -0.020000 9.06e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 36 8.48e-01 -0.018500 8.95e-01
Metabolism of water-soluble vitamins and cofactors 119 7.29e-01 -0.018400 7.95e-01
Trafficking and processing of endosomal TLR 11 9.23e-01 -0.016800 9.50e-01
Sensory perception of taste 24 8.87e-01 0.016700 9.23e-01
Interleukin-10 signaling 35 8.65e-01 0.016600 9.06e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 9.03e-01 -0.016500 9.35e-01
Hh mutants are degraded by ERAD 54 8.34e-01 -0.016500 8.83e-01
Phospholipase C-mediated cascade: FGFR1 14 9.18e-01 0.016000 9.47e-01
Smooth Muscle Contraction 32 8.77e-01 -0.015800 9.15e-01
Class A/1 (Rhodopsin-like receptors) 185 7.14e-01 -0.015600 7.89e-01
PIWI-interacting RNA (piRNA) biogenesis 25 8.95e-01 0.015300 9.28e-01
TNFR2 non-canonical NF-kB pathway 91 8.11e-01 -0.014500 8.63e-01
GLI3 is processed to GLI3R by the proteasome 57 8.52e-01 -0.014300 8.98e-01
Cytochrome P450 - arranged by substrate type 44 8.71e-01 -0.014100 9.10e-01
Pregnenolone biosynthesis 11 9.38e-01 0.013400 9.58e-01
Transcriptional regulation of testis differentiation 11 9.39e-01 0.013300 9.58e-01
Processive synthesis on the C-strand of the telomere 19 9.21e-01 -0.013100 9.49e-01
Metabolism of RNA 677 5.60e-01 -0.013100 6.50e-01
Meiosis 77 8.47e-01 -0.012700 8.94e-01
Signaling by FGFR2 IIIa TM 19 9.25e-01 0.012500 9.51e-01
Collagen biosynthesis and modifying enzymes 64 8.69e-01 0.011900 9.09e-01
Hyaluronan metabolism 14 9.39e-01 0.011900 9.58e-01
Purine salvage 12 9.46e-01 -0.011200 9.62e-01
Regulation of TP53 Activity through Methylation 19 9.33e-01 -0.011200 9.55e-01
Early Phase of HIV Life Cycle 13 9.46e-01 -0.010900 9.62e-01
FRS-mediated FGFR2 signaling 22 9.30e-01 -0.010800 9.55e-01
mRNA Splicing 187 7.99e-01 0.010800 8.53e-01
Glucagon-type ligand receptors 25 9.27e-01 0.010600 9.52e-01
Caspase activation via Death Receptors in the presence of ligand 15 9.44e-01 -0.010600 9.61e-01
Hedgehog ligand biogenesis 63 8.86e-01 -0.010500 9.22e-01
p53-Dependent G1 DNA Damage Response 62 8.94e-01 -0.009770 9.28e-01
p53-Dependent G1/S DNA damage checkpoint 62 8.94e-01 -0.009770 9.28e-01
Collagen chain trimerization 41 9.20e-01 0.009020 9.49e-01
Signaling by NOTCH4 81 8.89e-01 -0.009010 9.23e-01
Dual incision in TC-NER 65 9.05e-01 -0.008560 9.35e-01
Metabolism of steroid hormones 30 9.38e-01 0.008210 9.58e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 15 9.57e-01 -0.007980 9.70e-01
Hh mutants abrogate ligand secretion 57 9.18e-01 -0.007890 9.47e-01
Peroxisomal lipid metabolism 27 9.49e-01 -0.007170 9.64e-01
Reproduction 93 9.05e-01 0.007150 9.35e-01
Cyclin E associated events during G1/S transition 83 9.10e-01 -0.007140 9.40e-01
Degradation of GLI2 by the proteasome 57 9.32e-01 0.006560 9.55e-01
Cell Cycle Checkpoints 260 8.59e-01 -0.006400 9.04e-01
SHC-mediated cascade:FGFR1 19 9.62e-01 -0.006240 9.73e-01
G1/S DNA Damage Checkpoints 64 9.32e-01 -0.006210 9.55e-01
Gluconeogenesis 28 9.55e-01 0.006190 9.68e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 89 9.25e-01 0.005810 9.51e-01
Iron uptake and transport 56 9.41e-01 -0.005720 9.60e-01
Regulation of ornithine decarboxylase (ODC) 49 9.46e-01 0.005600 9.62e-01
Phase I - Functionalization of compounds 75 9.34e-01 -0.005560 9.56e-01
Termination of O-glycan biosynthesis 19 9.67e-01 -0.005410 9.76e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 9.42e-01 -0.005280 9.60e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 9.71e-01 0.005160 9.78e-01
SCF-beta-TrCP mediated degradation of Emi1 53 9.50e-01 0.004990 9.64e-01
Degradation of DVL 55 9.50e-01 0.004870 9.64e-01
Translesion Synthesis by POLH 18 9.76e-01 -0.004060 9.83e-01
Processing of DNA double-strand break ends 72 9.59e-01 -0.003540 9.70e-01
Regulation of Complement cascade 29 9.77e-01 0.003030 9.83e-01
Degradation of GLI1 by the proteasome 57 9.68e-01 -0.003020 9.76e-01
Centrosome maturation 81 9.63e-01 0.002940 9.73e-01
Recruitment of mitotic centrosome proteins and complexes 81 9.63e-01 0.002940 9.73e-01
Lysine catabolism 12 9.88e-01 0.002480 9.92e-01
Glycosphingolipid metabolism 41 9.79e-01 -0.002410 9.84e-01
mRNA Splicing - Major Pathway 179 9.62e-01 -0.002060 9.73e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 9.84e-01 0.001490 9.88e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 9.95e-01 -0.001120 9.96e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 9.95e-01 0.000742 9.96e-01
Regulation of Apoptosis 51 9.93e-01 0.000705 9.96e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 9.97e-01 -0.000511 9.98e-01
Anchoring of the basal body to the plasma membrane 97 9.94e-01 0.000412 9.96e-01
Integrin cell surface interactions 58 9.98e-01 -0.000210 9.98e-01


Detailed Gene set reports



CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation
136
set CLEC7A (Dectin-1) induces NFAT activation
setSize 11
pANOVA 1.83e-06
s.dist -0.831
p.adjustANOVA 1.26e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR1 -11467
ITPR3 -10385
NFATC2 -10372
PPP3R1 -10363
AHCYL1 -10321
ITPR2 -10230
NFATC1 -10050
NFATC3 -9699
PPP3CB -8774
PPP3CA -6485
CALM1 -3767

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR1 -11467
ITPR3 -10385
NFATC2 -10372
PPP3R1 -10363
AHCYL1 -10321
ITPR2 -10230
NFATC1 -10050
NFATC3 -9699
PPP3CB -8774
PPP3CA -6485
CALM1 -3767


Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin
206
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 1.05e-05
s.dist -0.804
p.adjustANOVA 6.09e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDS5A -11387
WAPL -10612
RAD21 -10332
STAG2 -10019
MAU2 -9731
NIPBL -9082
PDS5B -9033
SMC1A -8262
STAG1 -5541
SMC3 -5244

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDS5A -11387
WAPL -10612
RAD21 -10332
STAG2 -10019
MAU2 -9731
NIPBL -9082
PDS5B -9033
SMC1A -8262
STAG1 -5541
SMC3 -5244


MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
660
set MET activates RAP1 and RAC1
setSize 11
pANOVA 6.11e-06
s.dist -0.787
p.adjustANOVA 3.76e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL -11246
CRK -10821
GRB2 -10367
RAP1B -10068
RAPGEF1 -9979
MET -9354
GAB1 -8583
DOCK7 -8573
RAP1A -6032
RAC1 -5771
HGF -4913

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL -11246
CRK -10821
GRB2 -10367
RAP1B -10068
RAPGEF1 -9979
MET -9354
GAB1 -8583
DOCK7 -8573
RAP1A -6032
RAC1 -5771
HGF -4913


APC truncation mutants have impaired AXIN binding

APC truncation mutants have impaired AXIN binding
11
set APC truncation mutants have impaired AXIN binding
setSize 14
pANOVA 4.19e-07
s.dist -0.781
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


AXIN missense mutants destabilize the destruction complex

AXIN missense mutants destabilize the destruction complex
24
set AXIN missense mutants destabilize the destruction complex
setSize 14
pANOVA 4.19e-07
s.dist -0.781
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Signaling by AMER1 mutants

Signaling by AMER1 mutants
1171
set Signaling by AMER1 mutants
setSize 14
pANOVA 4.19e-07
s.dist -0.781
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Signaling by APC mutants

Signaling by APC mutants
1172
set Signaling by APC mutants
setSize 14
pANOVA 4.19e-07
s.dist -0.781
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Signaling by AXIN mutants

Signaling by AXIN mutants
1173
set Signaling by AXIN mutants
setSize 14
pANOVA 4.19e-07
s.dist -0.781
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Truncations of AMER1 destabilize the destruction complex

Truncations of AMER1 destabilize the destruction complex
1412
set Truncations of AMER1 destabilize the destruction complex
setSize 14
pANOVA 4.19e-07
s.dist -0.781
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


S33 mutants of beta-catenin aren’t phosphorylated

S33 mutants of beta-catenin aren’t phosphorylated
1106
set S33 mutants of beta-catenin aren’t phosphorylated
setSize 15
pANOVA 1.66e-07
s.dist -0.78
p.adjustANOVA 1.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


S37 mutants of beta-catenin aren’t phosphorylated

S37 mutants of beta-catenin aren’t phosphorylated
1107
set S37 mutants of beta-catenin aren’t phosphorylated
setSize 15
pANOVA 1.66e-07
s.dist -0.78
p.adjustANOVA 1.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


S45 mutants of beta-catenin aren’t phosphorylated

S45 mutants of beta-catenin aren’t phosphorylated
1108
set S45 mutants of beta-catenin aren’t phosphorylated
setSize 15
pANOVA 1.66e-07
s.dist -0.78
p.adjustANOVA 1.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Signaling by CTNNB1 phospho-site mutants

Signaling by CTNNB1 phospho-site mutants
1178
set Signaling by CTNNB1 phospho-site mutants
setSize 15
pANOVA 1.66e-07
s.dist -0.78
p.adjustANOVA 1.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Signaling by GSK3beta mutants

Signaling by GSK3beta mutants
1205
set Signaling by GSK3beta mutants
setSize 15
pANOVA 1.66e-07
s.dist -0.78
p.adjustANOVA 1.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


T41 mutants of beta-catenin aren’t phosphorylated

T41 mutants of beta-catenin aren’t phosphorylated
1296
set T41 mutants of beta-catenin aren’t phosphorylated
setSize 15
pANOVA 1.66e-07
s.dist -0.78
p.adjustANOVA 1.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752


Signaling by Hippo

Signaling by Hippo
1207
set Signaling by Hippo
setSize 20
pANOVA 6.57e-09
s.dist -0.749
p.adjustANOVA 7.73e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
AMOTL1 -11203
CASP3 -10662
STK4 -10633
YAP1 -10335
AMOTL2 -10306
LATS1 -10290
AMOT -9363
TJP2 -9213
SAV1 -9029
DVL2 -9009
MOB1B -8852
STK3 -8788
WWTR1 -8042
MOB1A -7934
YWHAE -7383
TJP1 -7227
NPHP4 -6510
LATS2 -5529
WWC1 -4350
YWHAB 668

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AMOTL1 -11203
CASP3 -10662
STK4 -10633
YAP1 -10335
AMOTL2 -10306
LATS1 -10290
AMOT -9363
TJP2 -9213
SAV1 -9029
DVL2 -9009
MOB1B -8852
STK3 -8788
WWTR1 -8042
MOB1A -7934
YWHAE -7383
TJP1 -7227
NPHP4 -6510
LATS2 -5529
WWC1 -4350
YWHAB 668


Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion
373
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 1.81e-05
s.dist -0.746
p.adjustANOVA 9.73e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDS5A -11387
WAPL -10612
ESCO1 -10457
RAD21 -10332
STAG2 -10019
PDS5B -9033
SMC1A -8262
STAG1 -5541
SMC3 -5244
ESCO2 -4962
CDCA5 -4010

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDS5A -11387
WAPL -10612
ESCO1 -10457
RAD21 -10332
STAG2 -10019
PDS5B -9033
SMC1A -8262
STAG1 -5541
SMC3 -5244
ESCO2 -4962
CDCA5 -4010


Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade
113
set Beta-catenin phosphorylation cascade
setSize 17
pANOVA 1.25e-07
s.dist -0.74
p.adjustANOVA 1.16e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
FRAT2 -5944
PPP2R5C -4400
PPP2R1B -3752
FRAT1 -2421

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
AXIN1 -11038
CSNK1A1 -11023
GSK3B -9938
PPP2R5A -9839
PPP2R5E -9609
AMER1 -8611
CTNNB1 -8504
APC -8095
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
FRAT2 -5944
PPP2R5C -4400
PPP2R1B -3752
FRAT1 -2421


ERKs are inactivated

ERKs are inactivated
358
set ERKs are inactivated
setSize 13
pANOVA 4.14e-06
s.dist -0.737
p.adjustANOVA 2.66e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
MAPK1 -11072
DUSP4 -10845
MAPK3 -10415
DUSP7 -9778
VRK3 -8696
PPP2R1A -7348
PPP2CA -7314
MAPK7 -6939
DUSP3 -5115
PPP2R1B -3752
DUSP6 -787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
MAPK1 -11072
DUSP4 -10845
MAPK3 -10415
DUSP7 -9778
VRK3 -8696
PPP2R1A -7348
PPP2CA -7314
MAPK7 -6939
DUSP3 -5115
PPP2R1B -3752
DUSP6 -787


Interleukin-6 signaling

Interleukin-6 signaling
605
set Interleukin-6 signaling
setSize 11
pANOVA 3.09e-05
s.dist -0.725
p.adjustANOVA 0.000159



Top enriched genes

Top 20 genes
GeneID Gene Rank
CBL -10978
JAK2 -10798
JAK1 -10594
STAT1 -10096
PTPN11 -9113
STAT3 -7915
IL6ST -7508
IL6R -7013
TYK2 -6251
SOCS3 -5490
IL6 -1086

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CBL -10978
JAK2 -10798
JAK1 -10594
STAT1 -10096
PTPN11 -9113
STAT3 -7915
IL6ST -7508
IL6R -7013
TYK2 -6251
SOCS3 -5490
IL6 -1086


HDMs demethylate histones

HDMs demethylate histones
511
set HDMs demethylate histones
setSize 22
pANOVA 6.47e-09
s.dist -0.715
p.adjustANOVA 7.67e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
KDM7A -11434
KDM1B -10992
KDM5B -10702
KDM4C -10302
KDM1A -10261
KDM2A -10244
KDM4B -10222
KDM6A -10140
KDM2B -10021
KDM5C -9795
PHF8 -9160
KDM5A -9002
KDM3A -8736
PHF2 -8710
JMJD6 -8352
KDM6B -7756
KDM3B -6731
KDM4A -6662
ARID5B -5854
KDM4D -5143

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KDM7A -11434.0
KDM1B -10992.0
KDM5B -10702.0
KDM4C -10302.0
KDM1A -10261.0
KDM2A -10244.0
KDM4B -10222.0
KDM6A -10140.0
KDM2B -10021.0
KDM5C -9795.0
PHF8 -9160.0
KDM5A -9002.0
KDM3A -8736.0
PHF2 -8710.0
JMJD6 -8352.0
KDM6B -7756.0
KDM3B -6731.0
KDM4A -6662.0
ARID5B -5854.0
KDM4D -5143.0
H3C1 1377.0
H3C15 8338.5


Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the late endosome membrane
1282
set Synthesis of PIPs at the late endosome membrane
setSize 11
pANOVA 7.55e-05
s.dist -0.689
p.adjustANOVA 0.000346



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIKFYVE -11087
MTMR9 -9769
MTMR2 -9653
VAC14 -9543
PIK3C2A -9163
PIK3C3 -9077
MTMR4 -8826
MTM1 -7734
PIK3R4 -6977
MTMR7 -650
FIG4 820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIKFYVE -11087
MTMR9 -9769
MTMR2 -9653
VAC14 -9543
PIK3C2A -9163
PIK3C3 -9077
MTMR4 -8826
MTM1 -7734
PIK3R4 -6977
MTMR7 -650
FIG4 820


Deadenylation of mRNA

Deadenylation of mRNA
262
set Deadenylation of mRNA
setSize 22
pANOVA 3.47e-08
s.dist -0.679
p.adjustANOVA 3.45e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNKS1BP1 -11414
CNOT7 -11127
CNOT1 -10965
EIF4B -10677
CNOT8 -10654
PABPC1 -10283
EIF4E -10097
EIF4A2 -9886
CNOT6L -9450
EIF4G1 -9102
CNOT11 -9081
PARN -8217
PAIP1 -8170
CNOT3 -7116
CNOT6 -6401
EIF4A1 -6282
PAN3 -5808
EIF4A3 -5781
CNOT4 -5456
CNOT10 -3665

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNKS1BP1 -11414
CNOT7 -11127
CNOT1 -10965
EIF4B -10677
CNOT8 -10654
PABPC1 -10283
EIF4E -10097
EIF4A2 -9886
CNOT6L -9450
EIF4G1 -9102
CNOT11 -9081
PARN -8217
PAIP1 -8170
CNOT3 -7116
CNOT6 -6401
EIF4A1 -6282
PAN3 -5808
EIF4A3 -5781
CNOT4 -5456
CNOT10 -3665
CNOT2 -1026
PAN2 10291


Unwinding of DNA

Unwinding of DNA
1420
set Unwinding of DNA
setSize 12
pANOVA 4.94e-05
s.dist 0.676
p.adjustANOVA 0.000239



Top enriched genes

Top 20 genes
GeneID Gene Rank
GINS2 14333
MCM3 14216
CDC45 14049
MCM5 13881
MCM8 13686
GINS3 13167
MCM2 12866
MCM4 12553
GINS1 12125
GINS4 11929
MCM7 -513
MCM6 -8231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GINS2 14333
MCM3 14216
CDC45 14049
MCM5 13881
MCM8 13686
GINS3 13167
MCM2 12866
MCM4 12553
GINS1 12125
GINS4 11929
MCM7 -513
MCM6 -8231


Cell-extracellular matrix interactions

Cell-extracellular matrix interactions
174
set Cell-extracellular matrix interactions
setSize 16
pANOVA 3.25e-06
s.dist -0.672
p.adjustANOVA 2.14e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
FLNA -11412
FLNC -11404
FERMT2 -11265
ITGB1 -10823
LIMS1 -10564
PXN -10479
ACTN1 -10130
PARVB -9617
VASP -8523
ILK -8046
PARVA -6732
TESK1 -6722
LIMS2 -5399
ARHGEF6 -4187
RSU1 -1626
FBLIM1 11772

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FLNA -11412
FLNC -11404
FERMT2 -11265
ITGB1 -10823
LIMS1 -10564
PXN -10479
ACTN1 -10130
PARVB -9617
VASP -8523
ILK -8046
PARVA -6732
TESK1 -6722
LIMS2 -5399
ARHGEF6 -4187
RSU1 -1626
FBLIM1 11772


Ephrin signaling

Ephrin signaling
369
set Ephrin signaling
setSize 19
pANOVA 4.19e-07
s.dist -0.67
p.adjustANOVA 3.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PAK1 -11332
EPHB6 -11224
SRC -11039
EPHB4 -10939
SDCBP -10764
EPHB2 -10272
EFNB2 -10181
PAK2 -9919
EFNB3 -9779
FYN -9643
NCK2 -8772
EPHB1 -7019
RAC1 -5771
PAK3 -4223
GIT1 -3711
EFNB1 -3364
MYL12A -2453
ARHGEF7 -2315
EPHB3 6369

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAK1 -11332
EPHB6 -11224
SRC -11039
EPHB4 -10939
SDCBP -10764
EPHB2 -10272
EFNB2 -10181
PAK2 -9919
EFNB3 -9779
FYN -9643
NCK2 -8772
EPHB1 -7019
RAC1 -5771
PAK3 -4223
GIT1 -3711
EFNB1 -3364
MYL12A -2453
ARHGEF7 -2315
EPHB3 6369


tRNA processing in the mitochondrion

tRNA processing in the mitochondrion
1479
set tRNA processing in the mitochondrion
setSize 20
pANOVA 2.52e-07
s.dist 0.666
p.adjustANOVA 2.11e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-CO3 14510
MT-CYB 14392
MT-CO1 14342
MT-ND3 14280
MT-CO2 14237
MT-RNR2 13980
MT-ATP8 13926
MT-ND2 13898
MT-RNR1 13892
MT-ATP6 13802
MT-ND4 13703
MT-ND1 13666
MT-ND4L 13647
MT-ND5 13494
MT-ND6 13393
HSD17B10 12939
TRMT10C 1336
TRNT1 -4293
ELAC2 -7408
PRORP -7800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-CO3 14510
MT-CYB 14392
MT-CO1 14342
MT-ND3 14280
MT-CO2 14237
MT-RNR2 13980
MT-ATP8 13926
MT-ND2 13898
MT-RNR1 13892
MT-ATP6 13802
MT-ND4 13703
MT-ND1 13666
MT-ND4L 13647
MT-ND5 13494
MT-ND6 13393
HSD17B10 12939
TRMT10C 1336
TRNT1 -4293
ELAC2 -7408
PRORP -7800


FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes
404
set FOXO-mediated transcription of cell cycle genes
setSize 15
pANOVA 1.01e-05
s.dist -0.658
p.adjustANOVA 5.98e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1A -11319
FOXO3 -11182
SMAD4 -10729
BTG1 -10371
RBL2 -10063
SMAD2 -10012
SMAD3 -9453
CDKN1B -8708
CAV1 -8579
FOXO1 -8481
CCNG2 -7777
FOXO4 -5888
KLF4 -3806
GADD45A -2655
PCBP4 13739

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1A -11319
FOXO3 -11182
SMAD4 -10729
BTG1 -10371
RBL2 -10063
SMAD2 -10012
SMAD3 -9453
CDKN1B -8708
CAV1 -8579
FOXO1 -8481
CCNG2 -7777
FOXO4 -5888
KLF4 -3806
GADD45A -2655
PCBP4 13739


RHO GTPases activate KTN1

RHO GTPases activate KTN1
951
set RHO GTPases activate KTN1
setSize 11
pANOVA 0.000159
s.dist -0.658
p.adjustANOVA 0.000676



Top enriched genes

Top 20 genes
GeneID Gene Rank
KIF5B -10270
RHOA -9853
CDC42 -9105
KTN1 -8591
RHOG -7757
KLC2 -7044
KLC1 -5920
RAC1 -5771
KLC3 -4947
KIF5A -4739
KLC4 -3143

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KIF5B -10270
RHOA -9853
CDC42 -9105
KTN1 -8591
RHOG -7757
KLC2 -7044
KLC1 -5920
RAC1 -5771
KLC3 -4947
KIF5A -4739
KLC4 -3143


Synthesis of PIPs at the Golgi membrane

Synthesis of PIPs at the Golgi membrane
1280
set Synthesis of PIPs at the Golgi membrane
setSize 15
pANOVA 1.39e-05
s.dist -0.648
p.adjustANOVA 7.7e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIKFYVE -11087
VAC14 -9543
PI4KB -9496
PIK3C2A -9163
PIK3C3 -9077
OCRL -8600
SACM1L -8271
PI4K2A -8075
ARF1 -7673
PI4K2B -7236
PIK3R4 -6977
ARF3 -6010
INPP5E -4476
FIG4 820
PI4KA 1574

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIKFYVE -11087
VAC14 -9543
PI4KB -9496
PIK3C2A -9163
PIK3C3 -9077
OCRL -8600
SACM1L -8271
PI4K2A -8075
ARF1 -7673
PI4K2B -7236
PIK3R4 -6977
ARF3 -6010
INPP5E -4476
FIG4 820
PI4KA 1574


Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the early endosome membrane
1281
set Synthesis of PIPs at the early endosome membrane
setSize 16
pANOVA 7.56e-06
s.dist -0.646
p.adjustANOVA 4.61e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTMR12 -11333
PIKFYVE -11087
MTMR2 -9653
VAC14 -9543
PIK3C2A -9163
PIK3C3 -9077
INPP4A -8977
MTMR4 -8826
INPP5F -8508
PI4K2A -8075
MTM1 -7734
PI4K2B -7236
PIK3R4 -6977
MTMR10 -1463
FIG4 820
INPP4B 6986

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTMR12 -11333
PIKFYVE -11087
MTMR2 -9653
VAC14 -9543
PIK3C2A -9163
PIK3C3 -9077
INPP4A -8977
MTMR4 -8826
INPP5F -8508
PI4K2A -8075
MTM1 -7734
PI4K2B -7236
PIK3R4 -6977
MTMR10 -1463
FIG4 820
INPP4B 6986


RAF-independent MAPK1/3 activation

RAF-independent MAPK1/3 activation
939
set RAF-independent MAPK1/3 activation
setSize 23
pANOVA 8.89e-08
s.dist -0.644
p.adjustANOVA 8.44e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK1 -11072
DUSP1 -10961
DUSP4 -10845
JAK2 -10798
DUSP5 -10695
JAK1 -10594
MAPK3 -10415
DUSP16 -10122
MAP2K1 -9906
DUSP7 -9778
PTPN11 -9113
PEA15 -8056
IL6ST -7508
IL6R -7013
DUSP8 -6809
TYK2 -6251
DUSP2 -5283
DUSP9 -4623
MAP2K2 -4059
DUSP10 -4048

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -11072
DUSP1 -10961
DUSP4 -10845
JAK2 -10798
DUSP5 -10695
JAK1 -10594
MAPK3 -10415
DUSP16 -10122
MAP2K1 -9906
DUSP7 -9778
PTPN11 -9113
PEA15 -8056
IL6ST -7508
IL6R -7013
DUSP8 -6809
TYK2 -6251
DUSP2 -5283
DUSP9 -4623
MAP2K2 -4059
DUSP10 -4048
IL6 -1086
DUSP6 -787
CDK1 12683


Signaling by Activin

Signaling by Activin
1174
set Signaling by Activin
setSize 15
pANOVA 1.82e-05
s.dist -0.639
p.adjustANOVA 9.75e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
INHBA -11377
MAPK1 -11072
SMAD4 -10729
MAPK3 -10415
SMAD2 -10012
SMAD3 -9453
FSTL3 -9248
ACVR2B -9085
ACVR2A -7472
DRAP1 -6016
ACVR1C -5189
ACVR1B -5120
FST -4186
INHBB -2225
FOXH1 10037

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INHBA -11377
MAPK1 -11072
SMAD4 -10729
MAPK3 -10415
SMAD2 -10012
SMAD3 -9453
FSTL3 -9248
ACVR2B -9085
ACVR2A -7472
DRAP1 -6016
ACVR1C -5189
ACVR1B -5120
FST -4186
INHBB -2225
FOXH1 10037


RORA activates gene expression

RORA activates gene expression
1001
set RORA activates gene expression
setSize 18
pANOVA 3.1e-06
s.dist -0.635
p.adjustANOVA 2.08e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPARA -11218
HELZ2 -11079
CREBBP -10976
EP300 -10826
NCOA2 -10725
CARM1 -10579
MED1 -10330
TBL1X -9308
TBL1XR1 -8542
TGS1 -8525
NCOA6 -8418
RXRA -8406
RORA -8157
CHD9 -8138
NCOA1 -7559
CPT1A -5402
SREBF1 13240
SMARCD3 14082

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPARA -11218
HELZ2 -11079
CREBBP -10976
EP300 -10826
NCOA2 -10725
CARM1 -10579
MED1 -10330
TBL1X -9308
TBL1XR1 -8542
TGS1 -8525
NCOA6 -8418
RXRA -8406
RORA -8157
CHD9 -8138
NCOA1 -7559
CPT1A -5402
SREBF1 13240
SMARCD3 14082


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
419
set Formation of ATP by chemiosmotic coupling
setSize 18
pANOVA 3.19e-06
s.dist 0.634
p.adjustANOVA 2.11e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5PD 14418
ATP5MC1 14370
ATP5ME 14326
ATP5MG 14131
ATP5F1D 14051
ATP5MF 14007
MT-ATP8 13926
MT-ATP6 13802
ATP5PO 13339
ATP5F1C 13210
ATP5PF 13153
ATP5MC2 12496
ATP5MC3 11608
DMAC2L 11333
ATP5F1E 9900
ATP5PB -4314
ATP5F1A -7964
ATP5F1B -9680

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5PD 14418
ATP5MC1 14370
ATP5ME 14326
ATP5MG 14131
ATP5F1D 14051
ATP5MF 14007
MT-ATP8 13926
MT-ATP6 13802
ATP5PO 13339
ATP5F1C 13210
ATP5PF 13153
ATP5MC2 12496
ATP5MC3 11608
DMAC2L 11333
ATP5F1E 9900
ATP5PB -4314
ATP5F1A -7964
ATP5F1B -9680


ALK mutants bind TKIs

ALK mutants bind TKIs
10
set ALK mutants bind TKIs
setSize 12
pANOVA 0.000152
s.dist -0.631
p.adjustANOVA 0.000653



Top enriched genes

Top 20 genes
GeneID Gene Rank
FN1 -11331
CLTC -10972
EIF2AK3 -10501
STRN -9522
HIP1 -9100
BIRC6 -8991
PRKAR1A -8908
ALK -8478
PPM1B -8081
EML4 -4306
NPM1 -1994
BCL11A 12105

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FN1 -11331
CLTC -10972
EIF2AK3 -10501
STRN -9522
HIP1 -9100
BIRC6 -8991
PRKAR1A -8908
ALK -8478
PPM1B -8081
EML4 -4306
NPM1 -1994
BCL11A 12105


Activation of RAC1

Activation of RAC1
48
set Activation of RAC1
setSize 13
pANOVA 8.69e-05
s.dist -0.629
p.adjustANOVA 0.000395



Top enriched genes

Top 20 genes
GeneID Gene Rank
PAK1 -11332
SLIT2 -11082
NCK1 -10455
SOS1 -10061
PAK2 -9919
ROBO1 -9823
NCK2 -8772
PAK4 -8769
RAC1 -5771
SOS2 -5653
PAK3 -4223
PAK6 1398
PAK5 8211

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAK1 -11332
SLIT2 -11082
NCK1 -10455
SOS1 -10061
PAK2 -9919
ROBO1 -9823
NCK2 -8772
PAK4 -8769
RAC1 -5771
SOS2 -5653
PAK3 -4223
PAK6 1398
PAK5 8211


Regulation of PTEN mRNA translation

Regulation of PTEN mRNA translation
1044
set Regulation of PTEN mRNA translation
setSize 12
pANOVA 0.000231
s.dist -0.614
p.adjustANOVA 0.000932



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGO2 -11303
VAPA -10560
TNRC6B -10436
AGO3 -10305
CNOT6L -9450
PTEN -9332
AGO1 -7708
TNRC6C -6209
AGO4 -5344
TNRC6A -4569
PTENP1 -3981
MOV10 11874

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGO2 -11303
VAPA -10560
TNRC6B -10436
AGO3 -10305
CNOT6L -9450
PTEN -9332
AGO1 -7708
TNRC6C -6209
AGO4 -5344
TNRC6A -4569
PTENP1 -3981
MOV10 11874


CTLA4 inhibitory signaling

CTLA4 inhibitory signaling
146
set CTLA4 inhibitory signaling
setSize 17
pANOVA 1.21e-05
s.dist -0.613
p.adjustANOVA 6.77e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
YES1 -11157
SRC -11039
AKT3 -10071
PPP2R5A -9839
FYN -9643
PPP2R5E -9609
PTPN11 -9113
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752
AKT1 -2828
LYN 6229
AKT2 10214

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
YES1 -11157
SRC -11039
AKT3 -10071
PPP2R5A -9839
FYN -9643
PPP2R5E -9609
PTPN11 -9113
PPP2R1A -7348
PPP2CA -7314
PPP2R5B -7063
PPP2R5C -4400
PPP2R1B -3752
AKT1 -2828
LYN 6229
AKT2 10214


STAT5 activation downstream of FLT3 ITD mutants

STAT5 activation downstream of FLT3 ITD mutants
1130
set STAT5 activation downstream of FLT3 ITD mutants
setSize 10
pANOVA 0.000826
s.dist -0.611
p.adjustANOVA 0.00283



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1A -11319
GRB2 -10367
GAB2 -9456
PIM1 -9154
PTPN11 -9113
STAT5A -8517
BCL2L1 -5576
NOX4 -5505
STAT5B -5411
FLT3 10394

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1A -11319
GRB2 -10367
GAB2 -9456
PIM1 -9154
PTPN11 -9113
STAT5A -8517
BCL2L1 -5576
NOX4 -5505
STAT5B -5411
FLT3 10394


ERK/MAPK targets

ERK/MAPK targets
357
set ERK/MAPK targets
setSize 22
pANOVA 8.88e-07
s.dist -0.605
p.adjustANOVA 6.51e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
MAPK1 -11072
DUSP4 -10845
MAPK3 -10415
RPS6KA3 -10402
DUSP7 -9778
RPS6KA2 -9623
MAPK14 -9489
ELK1 -8837
VRK3 -8696
RPS6KA5 -8526
PPP2R1A -7348
PPP2CA -7314
MAPK7 -6939
MEF2C -6540
MEF2A -6074
DUSP3 -5115
PPP2R1B -3752
DUSP6 -787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
MAPK1 -11072
DUSP4 -10845
MAPK3 -10415
RPS6KA3 -10402
DUSP7 -9778
RPS6KA2 -9623
MAPK14 -9489
ELK1 -8837
VRK3 -8696
RPS6KA5 -8526
PPP2R1A -7348
PPP2CA -7314
MAPK7 -6939
MEF2C -6540
MEF2A -6074
DUSP3 -5115
PPP2R1B -3752
DUSP6 -787
MAPK11 11137
RPS6KA1 13794


Complex I biogenesis

Complex I biogenesis
214
set Complex I biogenesis
setSize 57
pANOVA 5.61e-15
s.dist 0.598
p.adjustANOVA 2.08e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFB1 14506
NDUFA7 14483
NDUFAF3 14437
ACAD9 14363
NDUFA1 14353
NDUFA12 14348
NDUFV2 14312
NDUFB8 14309
NDUFA2 14297
MT-ND3 14280
NDUFS5 14273
NDUFB4 14220
NDUFA3 14207
NDUFA11 14169
NDUFB2 14156
COA1 14073
MT-ND2 13898
NDUFA13 13815
MT-ND4 13703
MT-ND1 13666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFB1 14506
NDUFA7 14483
NDUFAF3 14437
ACAD9 14363
NDUFA1 14353
NDUFA12 14348
NDUFV2 14312
NDUFB8 14309
NDUFA2 14297
MT-ND3 14280
NDUFS5 14273
NDUFB4 14220
NDUFA3 14207
NDUFA11 14169
NDUFB2 14156
COA1 14073
MT-ND2 13898
NDUFA13 13815
MT-ND4 13703
MT-ND1 13666
MT-ND5 13494
NDUFS7 13425
MT-ND6 13393
NDUFA8 13317
NDUFAF2 13267
NDUFB3 13112
NDUFB7 13062
NDUFC1 12738
NDUFS8 12718
NDUFB9 12633
NDUFS3 12474
NDUFA6 12455
NDUFS6 11867
NDUFV3 11569
NDUFB6 11337
NDUFC2 11100
NDUFA9 10641
NDUFAF7 10299
NDUFB11 10281
NDUFB10 10249
NDUFAF1 9621
NDUFA5 9255
NDUFAF6 8858
NDUFAF5 8736
NDUFS4 5902
ECSIT 4595
TIMMDC1 4050
NDUFV1 3727
TMEM126B -1581
NDUFAF4 -2850
TMEM186 -4724
NDUFB5 -5794
NUBPL -6091
NDUFA10 -6273
NDUFAB1 -6736
NDUFS1 -8887
NDUFS2 -8924


Signal transduction by L1

Signal transduction by L1
1167
set Signal transduction by L1
setSize 21
pANOVA 2.3e-06
s.dist -0.595
p.adjustANOVA 1.58e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITGA5 -11448
PAK1 -11332
CSNK2A2 -11291
CSNK2A1 -11139
MAPK1 -11072
ITGB1 -10823
ITGB3 -10603
FGFR1 -10522
EGFR -10456
MAPK3 -10415
ITGAV -9963
MAP2K1 -9906
VAV2 -7675
L1CAM -6965
NRP1 -6060
RAC1 -5771
MAP2K2 -4059
ITGA2B 4408
NCAM1 4642
CSNK2B 8404

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA5 -11448
PAK1 -11332
CSNK2A2 -11291
CSNK2A1 -11139
MAPK1 -11072
ITGB1 -10823
ITGB3 -10603
FGFR1 -10522
EGFR -10456
MAPK3 -10415
ITGAV -9963
MAP2K1 -9906
VAV2 -7675
L1CAM -6965
NRP1 -6060
RAC1 -5771
MAP2K2 -4059
ITGA2B 4408
NCAM1 4642
CSNK2B 8404
ITGA9 11807


Signaling by Leptin

Signaling by Leptin
1211
set Signaling by Leptin
setSize 10
pANOVA 0.00111
s.dist -0.595
p.adjustANOVA 0.0037



Top enriched genes

Top 20 genes
GeneID Gene Rank
JAK2 -10798
IRS1 -10066
IRS2 -10059
PTPN11 -9113
STAT5A -8517
LEPR -8359
STAT3 -7915
SOCS3 -5490
STAT5B -5411
SH2B1 13691

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JAK2 -10798
IRS1 -10066
IRS2 -10059
PTPN11 -9113
STAT5A -8517
LEPR -8359
STAT3 -7915
SOCS3 -5490
STAT5B -5411
SH2B1 13691


Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation
212
set Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize 11
pANOVA 0.000651
s.dist -0.594
p.adjustANOVA 0.00235



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGO2 -11303
VAPA -10560
TNRC6B -10436
AGO3 -10305
CNOT6L -9450
AGO1 -7708
TNRC6C -6209
AGO4 -5344
TNRC6A -4569
PTENP1 -3981
MOV10 11874

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGO2 -11303
VAPA -10560
TNRC6B -10436
AGO3 -10305
CNOT6L -9450
AGO1 -7708
TNRC6C -6209
AGO4 -5344
TNRC6A -4569
PTENP1 -3981
MOV10 11874


Prolonged ERK activation events

Prolonged ERK activation events
918
set Prolonged ERK activation events
setSize 14
pANOVA 0.000127
s.dist -0.591
p.adjustANOVA 0.000558



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL -11246
MAPK1 -11072
CRK -10821
MAPK3 -10415
RAPGEF1 -9979
MAP2K1 -9906
FRS2 -9394
BRAF -7448
RAP1A -6032
MAP2K2 -4059
KIDINS220 -2079
NTRK1 -1564
YWHAB 668
NGF 7236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL -11246
MAPK1 -11072
CRK -10821
MAPK3 -10415
RAPGEF1 -9979
MAP2K1 -9906
FRS2 -9394
BRAF -7448
RAP1A -6032
MAP2K2 -4059
KIDINS220 -2079
NTRK1 -1564
YWHAB 668
NGF 7236


Signaling by WNT in cancer

Signaling by WNT in cancer
1248
set Signaling by WNT in cancer
setSize 33
pANOVA 4.49e-09
s.dist -0.59
p.adjustANOVA 5.74e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
TNKS -11151
AXIN1 -11038
CSNK1A1 -11023
FZD8 -10164
LRP6 -9991
GSK3B -9938
PPP2R5A -9839
TNKS2 -9768
FZD4 -9761
PPP2R5E -9609
FZD5 -9574
AMER1 -8611
CTNNB1 -8504
APC -8095
KREMEN2 -8049
FZD6 -7908
CTBP2 -7367
PPP2R1A -7348

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -11385
PPP2CB -11199
TNKS -11151
AXIN1 -11038
CSNK1A1 -11023
FZD8 -10164
LRP6 -9991
GSK3B -9938
PPP2R5A -9839
TNKS2 -9768
FZD4 -9761
PPP2R5E -9609
FZD5 -9574
AMER1 -8611
CTNNB1 -8504
APC -8095
KREMEN2 -8049
FZD6 -7908
CTBP2 -7367
PPP2R1A -7348
PPP2CA -7314
KREMEN1 -7224
PPP2R5B -7063
PORCN -6198
DKK2 -5439
DKK1 -5426
PPP2R5C -4400
PPP2R1B -3752
RNF43 1822
WNT3A 2357
CTBP1 8786
TCF7L2 9371
LRP5 12739


Frs2-mediated activation

Frs2-mediated activation
436
set Frs2-mediated activation
setSize 12
pANOVA 0.000425
s.dist -0.587
p.adjustANOVA 0.00163



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL -11246
MAPK1 -11072
MAPK3 -10415
RAPGEF1 -9979
MAP2K1 -9906
FRS2 -9394
BRAF -7448
RAP1A -6032
MAP2K2 -4059
NTRK1 -1564
YWHAB 668
NGF 7236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL -11246
MAPK1 -11072
MAPK3 -10415
RAPGEF1 -9979
MAP2K1 -9906
FRS2 -9394
BRAF -7448
RAP1A -6032
MAP2K2 -4059
NTRK1 -1564
YWHAB 668
NGF 7236


YAP1- and WWTR1 (TAZ)-stimulated gene expression

YAP1- and WWTR1 (TAZ)-stimulated gene expression
1445
set YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize 12
pANOVA 0.000444
s.dist -0.585
p.adjustANOVA 0.0017



Top enriched genes

Top 20 genes
GeneID Gene Rank
HIPK1 -10895
YAP1 -10335
TEAD1 -10153
TEAD4 -9286
TEAD2 -9164
TEAD3 -8524
WWTR1 -8042
GATA4 -6335
RUNX2 -5578
HIPK2 -4908
NPPA 3503
KAT2B 6820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIPK1 -10895
YAP1 -10335
TEAD1 -10153
TEAD4 -9286
TEAD2 -9164
TEAD3 -8524
WWTR1 -8042
GATA4 -6335
RUNX2 -5578
HIPK2 -4908
NPPA 3503
KAT2B 6820


Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol
1288
set Synthesis of bile acids and bile salts via 27-hydroxycholesterol
setSize 10
pANOVA 0.00148
s.dist -0.58
p.adjustANOVA 0.00469



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCOA2 -10725
RXRA -8406
HSD3B7 -8010
NCOA1 -7559
AKR1C1 -6748
AKR1C3 -5292
CYP27A1 -5167
PTGIS -3939
AKR1C2 -3789
CYP8B1 -447

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCOA2 -10725
RXRA -8406
HSD3B7 -8010
NCOA1 -7559
AKR1C1 -6748
AKR1C3 -5292
CYP27A1 -5167
PTGIS -3939
AKR1C2 -3789
CYP8B1 -447


MAPK3 (ERK1) activation

MAPK3 (ERK1) activation
655
set MAPK3 (ERK1) activation
setSize 10
pANOVA 0.0015
s.dist -0.58
p.adjustANOVA 0.00474



Top enriched genes

Top 20 genes
GeneID Gene Rank
JAK2 -10798
JAK1 -10594
MAPK3 -10415
MAP2K1 -9906
PTPN11 -9113
IL6ST -7508
IL6R -7013
TYK2 -6251
IL6 -1086
CDK1 12683

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JAK2 -10798
JAK1 -10594
MAPK3 -10415
MAP2K1 -9906
PTPN11 -9113
IL6ST -7508
IL6R -7013
TYK2 -6251
IL6 -1086
CDK1 12683


MET receptor recycling

MET receptor recycling
663
set MET receptor recycling
setSize 10
pANOVA 0.00164
s.dist -0.575
p.adjustANOVA 0.00513



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL -11246
CRK -10821
GRB2 -10367
MET -9354
GAB1 -8583
ARF6 -7000
HGF -4913
GGA3 -4188
RAB4A -2018
RAB4B 9090

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL -11246
CRK -10821
GRB2 -10367
MET -9354
GAB1 -8583
ARF6 -7000
HGF -4913
GGA3 -4188
RAB4A -2018
RAB4B 9090


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.2.2              echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.1               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58                 fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [23] IRanges_2.30.0              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.9                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.7                ggplot2_3.3.6              
## [35] tidyverse_1.3.1             zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.7             polylabelr_0.2.0      
##   [7] splines_4.2.1          BiocParallel_1.30.3    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.3            magrittr_2.0.3        
##  [13] memoise_2.0.1          tzdb_0.3.0             Biostrings_2.64.0     
##  [16] annotate_1.74.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.3             rvest_1.0.2           
##  [22] haven_2.5.0            xfun_0.31              crayon_1.5.1          
##  [25] RCurl_1.98-1.7         jsonlite_1.8.0         genefilter_1.78.0     
##  [28] survival_3.4-0         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.42.0        XVector_0.36.0        
##  [34] webshot_0.5.3          DelayedArray_0.22.0    scales_1.2.0          
##  [37] DBI_1.1.3              Rcpp_1.0.8.3           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.3             RColorBrewer_1.1-3     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.9          XML_3.99-0.10         
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       rlang_1.0.3           
##  [55] later_1.3.0            AnnotationDbi_1.58.0   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.1            cachem_1.0.6          
##  [61] cli_3.3.0              generics_0.1.2         RSQLite_2.2.14        
##  [64] broom_0.8.0            evaluate_0.15          fastmap_1.1.0         
##  [67] yaml_2.3.5             knitr_1.39             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.36.2       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.1        
##  [76] rstudioapi_0.13        png_0.1-7              reprex_2.0.1          
##  [79] geneplotter_1.74.0     bslib_0.3.1            stringi_1.7.6         
##  [82] highr_0.9              lattice_0.20-45        Matrix_1.4-1          
##  [85] vctrs_0.4.1            pillar_1.7.0           lifecycle_1.0.1       
##  [88] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [91] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [94] KernSmooth_2.23-20     gridExtra_2.3          codetools_0.2-18      
##  [97] assertthat_0.2.1       withr_2.5.0            GenomeInfoDbData_1.2.8
## [100] parallel_4.2.1         hms_1.1.1              grid_4.2.1            
## [103] rmarkdown_2.14         shiny_1.7.1            lubridate_1.8.0

END of report