Mitch Report

date generated: 2022-08-23

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA 12.7959349
## 7SK        0.6300779
## A1BG       2.0722835
## A1BG-AS1   2.0755802
## A1CF      -1.0374222
## A2M        1.8496539

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	24
num_genes_in_profile	26025
duplicated_genes_present	0
num_profile_genes_in_sets	2733
num_profile_genes_not_in_sets	23292

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:

Gene sets metrics

	Gene sets metrics
num_genesets	24
num_genesets_excluded	0
num_genesets_included	24

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 24 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Complex I biogenesis	57	5.61e-15	0.5980	1.35e-13
Receptor Mediated Mitophagy	11	1.34e-03	-0.5580	2.48e-03
Nucleotide biosynthesis	12	3.28e-03	-0.4900	5.25e-03
Respiratory electron transport	103	4.49e-14	0.4300	5.39e-13
Resolution of D-Loop Structures	33	4.75e-04	0.3510	1.27e-03
Mitochondrial translation	96	6.45e-09	0.3430	3.87e-08
Mitophagy	28	6.29e-03	-0.2980	8.88e-03
Reduction of cytosolic Ca++ levels	12	7.98e-02	-0.2920	1.01e-01
Phospholipid metabolism	190	2.39e-11	-0.2810	1.91e-10
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.34e-03	-0.2570	2.48e-03
Cellular response to starvation	150	1.31e-07	0.2490	6.27e-07
PTEN Regulation	140	1.55e-05	-0.2110	4.65e-05
Mitochondrial biogenesis	91	8.07e-04	-0.2030	1.94e-03
Gene Silencing by RNA	97	8.93e-04	-0.1950	1.95e-03
Mucopolysaccharidoses	11	3.00e-01	0.1810	3.27e-01
Signaling by the B Cell Receptor (BCR)	105	2.52e-03	-0.1710	4.31e-03
Mitochondrial iron-sulfur cluster biogenesis	13	3.26e-01	0.1570	3.41e-01
Metabolism of amino acids and derivatives	342	6.16e-07	0.1570	2.11e-06
Diseases of carbohydrate metabolism	29	1.63e-01	0.1500	1.95e-01
Nervous system development	527	2.29e-07	-0.1310	9.17e-07
Oxidative Stress Induced Senescence	83	5.77e-02	-0.1200	7.69e-02
Mitochondrial protein import	64	1.70e-01	0.0990	1.95e-01
Metabolism	1885	5.44e-03	-0.0384	8.16e-03
Stabilization of p53	53	7.70e-01	0.0232	7.70e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Complex I biogenesis	57	5.61e-15	0.5980	1.35e-13
Receptor Mediated Mitophagy	11	1.34e-03	-0.5580	2.48e-03
Nucleotide biosynthesis	12	3.28e-03	-0.4900	5.25e-03
Respiratory electron transport	103	4.49e-14	0.4300	5.39e-13
Resolution of D-Loop Structures	33	4.75e-04	0.3510	1.27e-03
Mitochondrial translation	96	6.45e-09	0.3430	3.87e-08
Mitophagy	28	6.29e-03	-0.2980	8.88e-03
Reduction of cytosolic Ca++ levels	12	7.98e-02	-0.2920	1.01e-01
Phospholipid metabolism	190	2.39e-11	-0.2810	1.91e-10
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.34e-03	-0.2570	2.48e-03
Cellular response to starvation	150	1.31e-07	0.2490	6.27e-07
PTEN Regulation	140	1.55e-05	-0.2110	4.65e-05
Mitochondrial biogenesis	91	8.07e-04	-0.2030	1.94e-03
Gene Silencing by RNA	97	8.93e-04	-0.1950	1.95e-03
Mucopolysaccharidoses	11	3.00e-01	0.1810	3.27e-01
Signaling by the B Cell Receptor (BCR)	105	2.52e-03	-0.1710	4.31e-03
Mitochondrial iron-sulfur cluster biogenesis	13	3.26e-01	0.1570	3.41e-01
Metabolism of amino acids and derivatives	342	6.16e-07	0.1570	2.11e-06
Diseases of carbohydrate metabolism	29	1.63e-01	0.1500	1.95e-01
Nervous system development	527	2.29e-07	-0.1310	9.17e-07
Oxidative Stress Induced Senescence	83	5.77e-02	-0.1200	7.69e-02
Mitochondrial protein import	64	1.70e-01	0.0990	1.95e-01
Metabolism	1885	5.44e-03	-0.0384	8.16e-03
Stabilization of p53	53	7.70e-01	0.0232	7.70e-01

---

Detailed Gene set reports

Complex I biogenesis

Complex I biogenesis

	2
set	Complex I biogenesis
setSize	57
pANOVA	5.61e-15
s.dist	0.598
p.adjustANOVA	1.35e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NDUFB1	14506
NDUFA7	14483
NDUFAF3	14437
ACAD9	14363
NDUFA1	14353
NDUFA12	14348
NDUFV2	14312
NDUFB8	14309
NDUFA2	14297
MT-ND3	14280
NDUFS5	14273
NDUFB4	14220
NDUFA3	14207
NDUFA11	14169
NDUFB2	14156
COA1	14073
MT-ND2	13898
NDUFA13	13815
MT-ND4	13703
MT-ND1	13666

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NDUFB1	14506
NDUFA7	14483
NDUFAF3	14437
ACAD9	14363
NDUFA1	14353
NDUFA12	14348
NDUFV2	14312
NDUFB8	14309
NDUFA2	14297
MT-ND3	14280
NDUFS5	14273
NDUFB4	14220
NDUFA3	14207
NDUFA11	14169
NDUFB2	14156
COA1	14073
MT-ND2	13898
NDUFA13	13815
MT-ND4	13703
MT-ND1	13666
MT-ND5	13494
NDUFS7	13425
MT-ND6	13393
NDUFA8	13317
NDUFAF2	13267
NDUFB3	13112
NDUFB7	13062
NDUFC1	12738
NDUFS8	12718
NDUFB9	12633
NDUFS3	12474
NDUFA6	12455
NDUFS6	11867
NDUFV3	11569
NDUFB6	11337
NDUFC2	11100
NDUFA9	10641
NDUFAF7	10299
NDUFB11	10281
NDUFB10	10249
NDUFAF1	9621
NDUFA5	9255
NDUFAF6	8858
NDUFAF5	8736
NDUFS4	5902
ECSIT	4595
TIMMDC1	4050
NDUFV1	3727
TMEM126B	-1581
NDUFAF4	-2850
TMEM186	-4724
NDUFB5	-5794
NUBPL	-6091
NDUFA10	-6273
NDUFAB1	-6736
NDUFS1	-8887
NDUFS2	-8924

---

Receptor Mediated Mitophagy

Receptor Mediated Mitophagy

	19
set	Receptor Mediated Mitophagy
setSize	11
pANOVA	0.00134
s.dist	-0.558
p.adjustANOVA	0.00248

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2A2	-11291
CSNK2A1	-11139
SRC	-11039
ULK1	-9775
PGAM5	-8926
ATG5	-8626
MAP1LC3B	-7801
ATG12	-6471
MAP1LC3A	-4620
FUNDC1	8326
CSNK2B	8404

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2A2	-11291
CSNK2A1	-11139
SRC	-11039
ULK1	-9775
PGAM5	-8926
ATG5	-8626
MAP1LC3B	-7801
ATG12	-6471
MAP1LC3A	-4620
FUNDC1	8326
CSNK2B	8404

---

Nucleotide biosynthesis

Nucleotide biosynthesis

	14
set	Nucleotide biosynthesis
setSize	12
pANOVA	0.00328
s.dist	-0.49
p.adjustANOVA	0.00525

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CAD	-11056
PPAT	-10754
GART	-10753
IMPDH2	-10082
ATIC	-8945
PAICS	-8895
IMPDH1	-7343
GMPS	-7233
ADSL	-4520
UMPS	-3798
DHODH	12023
PFAS	13335

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CAD	-11056
PPAT	-10754
GART	-10753
IMPDH2	-10082
ATIC	-8945
PAICS	-8895
IMPDH1	-7343
GMPS	-7233
ADSL	-4520
UMPS	-3798
DHODH	12023
PFAS	13335

---

Respiratory electron transport

Respiratory electron transport

	22
set	Respiratory electron transport
setSize	103
pANOVA	4.49e-14
s.dist	0.43
p.adjustANOVA	5.39e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-CO3	14510
NDUFB1	14506
NDUFA7	14483
UQCRQ	14468
NDUFAF3	14437
MT-CYB	14392
ACAD9	14363
NDUFA1	14353
NDUFA12	14348
MT-CO1	14342
NDUFV2	14312
NDUFB8	14309
COX7B	14304
NDUFA2	14297
MT-ND3	14280
NDUFS5	14273
COX5B	14239
MT-CO2	14237
COX6A1	14228
NDUFB4	14220

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-CO3	14510
NDUFB1	14506
NDUFA7	14483
UQCRQ	14468
NDUFAF3	14437
MT-CYB	14392
ACAD9	14363
NDUFA1	14353
NDUFA12	14348
MT-CO1	14342
NDUFV2	14312
NDUFB8	14309
COX7B	14304
NDUFA2	14297
MT-ND3	14280
NDUFS5	14273
COX5B	14239
MT-CO2	14237
COX6A1	14228
NDUFB4	14220
NDUFA3	14207
COX6C	14196
NDUFA11	14169
NDUFB2	14156
COA1	14073
COX4I1	14066
UQCRB	13949
COX6B1	13927
MT-ND2	13898
COX7C	13865
NDUFA13	13815
MT-ND4	13703
MT-ND1	13666
MT-ND5	13494
NDUFS7	13425
MT-ND6	13393
NDUFA8	13317
NDUFAF2	13267
NDUFB3	13112
NDUFB7	13062
UQCR10	12852
NDUFA4	12760
COX8A	12759
NDUFC1	12738
NDUFS8	12718
NDUFB9	12633
UQCRH	12519
NDUFS3	12474
NDUFA6	12455
NDUFS6	11867
COX5A	11835
NDUFV3	11569
NDUFB6	11337
UQCR11	11196
NDUFC2	11100
SURF1	11097
NDUFA9	10641
NDUFAF7	10299
NDUFB11	10281
TACO1	10270
NDUFB10	10249
COX16	9979
NDUFAF1	9621
NDUFA5	9255
COQ10A	8865
NDUFAF6	8858
NDUFAF5	8736
CYCS	8083
COX19	6070
NDUFS4	5902
UQCRC1	5081
ECSIT	4595
TIMMDC1	4050
NDUFV1	3727
SDHB	3363
COX20	975
ETFDH	569
COX14	-62
TMEM126B	-1581
SDHC	-2327
COX11	-2487
NDUFAF4	-2850
CYC1	-4267
SCO2	-4707
TMEM186	-4724
NDUFB5	-5794
COX18	-5882
NUBPL	-6091
NDUFA10	-6273
NDUFAB1	-6736
SDHD	-7510
ETFA	-7730
ETFB	-8235
COX7A2L	-8528
NDUFS1	-8887
NDUFS2	-8924
TRAP1	-9012
COQ10B	-9098
SCO1	-9463
LRPPRC	-9521
UQCRC2	-10163
UQCRFS1	-10752
SDHA	-10893

---

Resolution of D-Loop Structures

Resolution of D-Loop Structures

	21
set	Resolution of D-Loop Structures
setSize	33
pANOVA	0.000475
s.dist	0.351
p.adjustANOVA	0.00127

Top enriched genes

Top 20 genes

GeneID	Gene Rank
XRCC3	14408
EME1	14387
RTEL1	14219
SLX1A	14138
XRCC2	13931
DNA2	13645
GEN1	13607
RAD51C	13211
EXO1	13160
BRCA1	12920
BLM	12297
RAD51D	11930
MUS81	11918
RAD51AP1	11529
MRE11	11457
SPIDR	11455
EME2	11249
RMI2	11195
RAD51	11044
BRIP1	10747

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
XRCC3	14408
EME1	14387
RTEL1	14219
SLX1A	14138
XRCC2	13931
DNA2	13645
GEN1	13607
RAD51C	13211
EXO1	13160
BRCA1	12920
BLM	12297
RAD51D	11930
MUS81	11918
RAD51AP1	11529
MRE11	11457
SPIDR	11455
EME2	11249
RMI2	11195
RAD51	11044
BRIP1	10747
SLX4	9571
RAD51B	2677
RMI1	1516
BRCA2	1025
ATM	-5318
RBBP8	-5598
KAT5	-6588
RAD50	-6845
BARD1	-7002
PALB2	-7987
TOP3A	-8176
NBN	-8296
WRN	-9897

---

Mitochondrial translation

Mitochondrial translation

	10
set	Mitochondrial translation
setSize	96
pANOVA	6.45e-09
s.dist	0.343
p.adjustANOVA	3.87e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL57	14490
MRPS21	14427
MRPL23	14410
MRPS15	14352
MRPL24	14244
MRPL27	14200
MRPL52	14199
GADD45GIP1	14142
MRPL22	14117
MRPL53	14103
MRPL47	14071
MRPL16	14062
MT-RNR2	13980
OXA1L	13957
MRPL34	13918
MRPL40	13914
MT-RNR1	13892
MRPS31	13871
CHCHD1	13773
MRPL41	13748

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL57	14490
MRPS21	14427
MRPL23	14410
MRPS15	14352
MRPL24	14244
MRPL27	14200
MRPL52	14199
GADD45GIP1	14142
MRPL22	14117
MRPL53	14103
MRPL47	14071
MRPL16	14062
MT-RNR2	13980
OXA1L	13957
MRPL34	13918
MRPL40	13914
MT-RNR1	13892
MRPS31	13871
CHCHD1	13773
MRPL41	13748
MRPS36	13717
MRPS25	13629
MRPL55	13580
MRPL1	13402
MRPS28	13271
AURKAIP1	13247
MRPL20	13237
MRPL38	13232
MRPL32	13214
MRPS33	13021
MRPS17	12916
MRPL48	12846
MRPL21	12840
MRPL18	12801
MRPL12	12795
MRPL54	12690
MRPS7	12339
MRPL11	12218
TSFM	12074
MRPL35	11893
MRPL58	11786
MRRF	11638
MRPL43	11636
MRPL51	11587
MRPL33	11535
MRPS16	11519
ERAL1	11079
MRPL14	10979
PTCD3	10960
MRPS18C	10772
MRPS26	10709
MRPS14	10318
MRPL17	10117
MRPL28	9025
MTIF3	8696
MRPS9	8176
MRPL42	7092
MRPL2	5680
MRPL39	5297
MRPL13	4462
MRPL50	2952
MRPS22	2583
MRPL19	1396
MTIF2	1394
MRPS24	993
MRPS23	-633
MRPL10	-1171
MRPS18A	-2501
MTFMT	-2812
TUFM	-2872
MRPL15	-2960
DAP3	-3330
MRPL9	-3792
GFM2	-3938
MRPL30	-4090
MRPL3	-4226
MRPS5	-4450
MRPS27	-4728
MRPL46	-5042
MRPS34	-5119
MRPS12	-5506
MTRF1L	-5552
MRPL36	-5643
MRPL4	-5748
MRPS11	-6191
MRPL45	-6224
MRPS10	-6596
GFM1	-7015
MRPL44	-7944
MRPS2	-8026
MRPS18B	-8032
MRPL37	-8290
MRPL49	-8500
MRPS35	-9141
MRPS6	-9178
MRPS30	-9754

---

Mitophagy

Mitophagy

	11
set	Mitophagy
setSize	28
pANOVA	0.00629
s.dist	-0.298
p.adjustANOVA	0.00888

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2A2	-11291
CSNK2A1	-11139
SRC	-11039
TOMM20	-10251
ULK1	-9775
PINK1	-9648
TOMM70	-9207
SQSTM1	-9068
MFN2	-9032
PGAM5	-8926
ATG5	-8626
MAP1LC3B	-7801
MFN1	-7632
ATG12	-6471
TOMM22	-5917
UBC	-5726
TOMM7	-4735
MAP1LC3A	-4620
TOMM6	-325
RPS27A	6354

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2A2	-11291
CSNK2A1	-11139
SRC	-11039
TOMM20	-10251
ULK1	-9775
PINK1	-9648
TOMM70	-9207
SQSTM1	-9068
MFN2	-9032
PGAM5	-8926
ATG5	-8626
MAP1LC3B	-7801
MFN1	-7632
ATG12	-6471
TOMM22	-5917
UBC	-5726
TOMM7	-4735
MAP1LC3A	-4620
TOMM6	-325
RPS27A	6354
VDAC1	6976
FUNDC1	8326
CSNK2B	8404
UBA52	9786
UBB	10720
TOMM5	11112
MTERF3	11626
TOMM40	12491

---

Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels

	20
set	Reduction of cytosolic Ca++ levels
setSize	12
pANOVA	0.0798
s.dist	-0.292
p.adjustANOVA	0.101

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP2B4	-11202
ATP2A2	-10576
ATP2B1	-9876
SRI	-8512
ATP2A3	-3816
CALM1	-3767
SLC8A2	-2579
ATP2B2	-1662
SLC8A1	-1515
ATP2A1	8341
ATP2B3	8974
SLC8A3	9085

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP2B4	-11202
ATP2A2	-10576
ATP2B1	-9876
SRI	-8512
ATP2A3	-3816
CALM1	-3767
SLC8A2	-2579
ATP2B2	-1662
SLC8A1	-1515
ATP2A1	8341
ATP2B3	8974
SLC8A3	9085

---

Phospholipid metabolism

Phospholipid metabolism

	17
set	Phospholipid metabolism
setSize	190
pANOVA	2.39e-11
s.dist	-0.281
p.adjustANOVA	1.91e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PLEKHA2	-11369
MTMR12	-11333
CSNK2A2	-11291
CPNE3	-11208
CSNK2A1	-11139
PITPNM1	-11108
PIKFYVE	-11087
SBF2	-11066
AGPAT5	-11063
PLA2G4A	-11011
DDHD2	-10981
AGPAT3	-10751
RAB14	-10691
PITPNB	-10671
PIK3CB	-10645
LPIN2	-10393
MTMR3	-10361
PNPLA8	-10347
SELENOI	-9980
MBOAT2	-9975

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PLEKHA2	-11369.0
MTMR12	-11333.0
CSNK2A2	-11291.0
CPNE3	-11208.0
CSNK2A1	-11139.0
PITPNM1	-11108.0
PIKFYVE	-11087.0
SBF2	-11066.0
AGPAT5	-11063.0
PLA2G4A	-11011.0
DDHD2	-10981.0
AGPAT3	-10751.0
RAB14	-10691.0
PITPNB	-10671.0
PIK3CB	-10645.0
LPIN2	-10393.0
MTMR3	-10361.0
PNPLA8	-10347.0
SELENOI	-9980.0
MBOAT2	-9975.0
DDHD1	-9969.0
MIGA1	-9939.0
OSBPL8	-9817.0
MTMR9	-9769.0
PNPLA3	-9765.0
PLD6	-9737.0
MTMR6	-9692.0
MTMR2	-9653.0
PLEKHA1	-9553.0
VAC14	-9543.0
RAB5A	-9531.0
PI4KB	-9496.0
LPIN1	-9442.0
PIK3CA	-9420.0
PLEKHA5	-9391.0
TNFAIP8L1	-9350.0
PTEN	-9332.0
LCLAT1	-9226.0
PIK3C2A	-9163.0
PLEKHA3	-9139.0
PLA2G5	-9127.0
PIK3C3	-9077.0
INPP4A	-8977.0
PLD2	-8858.0
MTMR4	-8826.0
PLEKHA8	-8823.0
PTDSS1	-8621.0
OCRL	-8600.0
GPAT4	-8588.0
CEPT1	-8551.0
INPP5F	-8508.0
STARD10	-8425.0
MFSD2A	-8329.0
GPAT3	-8280.0
SACM1L	-8271.0
SBF1	-8246.0
PIK3CD	-8192.0
TNFAIP8	-8155.0
OSBPL5	-8117.0
STARD7	-8107.0
CDIPT	-8096.0
PI4K2A	-8075.0
HADHB	-8019.0
PIP4K2C	-8006.0
PNPLA6	-8005.0
CRLS1	-7928.0
PIP5K1A	-7879.0
MTM1	-7734.0
ARF1	-7673.0
PISD	-7556.0
ETNK2	-7503.0
ABHD4	-7493.0
PIK3R2	-7425.0
DGAT2	-7406.0
PIK3R1	-7281.0
AGPAT4	-7257.0
PI4K2B	-7236.0
LPCAT2	-7162.0
SYNJ1	-7131.0
OSBPL10	-7080.0
GPD2	-7016.0
INPPL1	-6979.0
PIK3R4	-6977.0
MBOAT7	-6934.0
SLC44A1	-6788.0
PLA2G15	-6678.0
MBOAT1	-6653.0
PIP4K2A	-6515.0
ETNK1	-6364.0
LPGAT1	-6263.0
LPCAT4	-6245.0
GDE1	-6206.0
PGS1	-6135.0
ARF3	-6010.0
LPCAT1	-5958.0
PITPNM2	-5889.0
PNPLA2	-5775.0
PIP5K1C	-5658.0
PIP5K1B	-5475.0
GPAM	-5433.0
CHPT1	-5261.0
GDPD5	-5213.0
HADHA	-5205.0
PCYT1A	-5159.0
PLA2G12A	-4921.0
SLC44A5	-4835.0
CDS1	-4605.0
INPP5E	-4476.0
PIK3C2B	-4439.0
PLAAT1	-4217.0
GPCPD1	-4156.0
GDPD1	-3975.0
MTMR1	-3303.0
PIP4K2B	-2814.0
SYNJ2	-2660.0
RAB4A	-2018.0
PIK3CG	-1735.0
MTMR10	-1463.0
PLA2G4C	-1387.0
PIK3R5	-1126.0
CDS2	-898.0
MTMR7	-650.0
GDPD3	212.0
GNPAT	546.0
INPP5K	731.0
FIG4	820.0
PEMT	894.0
MTMR14	942.0
CHAT	1099.0
PLA2G4F	1299.0
PI4KA	1574.0
PITPNM3	1641.0
PLA1A	1682.0
AGPAT1	2591.0
ETNPPL	2700.0
ENPP6	2900.0
GPD1L	3037.0
GPAT2	3176.0
PLB1	3552.0
SLC44A2	3724.0
PLD3	3892.0
PLA2G2D	4142.5
PLA2G10	4371.5
PLA2G4D	5502.0
PCTP	5611.0
GPD1	5824.0
AGPAT2	6129.0
PIK3R3	6184.0
PHOSPHO1	6325.0
LIPH	6706.0
INPP5J	6757.0
INPP4B	6986.0
TNFAIP8L3	7113.0
MIGA2	8037.0
SLC44A3	8216.0
PLAAT2	8286.0
CSNK2B	8404.0
CPNE1	8532.0
PLD4	9002.0
DGAT1	9037.0
MGLL	9097.0
ACHE	9574.0
TMEM86B	9701.0
LPIN3	9832.0
PLEKHA4	10387.0
PNPLA7	10513.0
PTDSS2	11183.0
PTPN13	11427.0
PCYT2	11567.0
CHKA	11745.0
BCHE	11836.0
INPP5D	11988.0
RUFY1	11989.0
ABHD3	12013.0
ACP6	12041.0
CPNE7	12203.0
PLEKHA6	12251.0
PLA2G6	12281.0
PTPMT1	12375.0
PLA2R1	12593.0
PLD1	12623.0
PLBD1	13591.0
LPCAT3	13697.0
TAZ	13790.0
AGK	14043.0
PLAAT4	14146.0
PIK3R6	14180.0
CHKB	14316.0
PLA2G4B	14436.0
PLAAT3	14549.0

---

Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle

	18
set	Pyruvate metabolism and Citric Acid (TCA) cycle
setSize	52
pANOVA	0.00134
s.dist	-0.257
p.adjustANOVA	0.00248

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ME2	-11120
SLC16A1	-10918
SDHA	-10893
CS	-10726
DLST	-10558
MDH2	-10507
IDH2	-10005
PDK1	-9644
DLD	-9418
NNT	-9376
PDP2	-9195
SUCLG2	-8734
PPARD	-8706
LDHA	-8640
PDK3	-8617
DLAT	-8520
RXRA	-8406
PDPR	-8207
L2HGDH	-8114
OGDH	-7841

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ME2	-11120
SLC16A1	-10918
SDHA	-10893
CS	-10726
DLST	-10558
MDH2	-10507
IDH2	-10005
PDK1	-9644
DLD	-9418
NNT	-9376
PDP2	-9195
SUCLG2	-8734
PPARD	-8706
LDHA	-8640
PDK3	-8617
DLAT	-8520
RXRA	-8406
PDPR	-8207
L2HGDH	-8114
OGDH	-7841
SDHD	-7510
IDH3A	-7252
PDHX	-7154
SUCLA2	-6659
ME1	-6239
GLO1	-5553
IDH3B	-5279
ACO2	-4725
ME3	-4136
SDHC	-2327
PDP1	-2326
FAHD1	-910
PDHA1	94
LDHB	979
MPC2	1693
LDHC	2515
LDHAL6A	3237
SDHB	3363
SLC16A3	4341
VDAC1	6976
IDH3G	8297
ADHFE1	9248
PDK4	9281
MPC1	10400
SUCLG1	10506
D2HGDH	10515
FH	10893
PDK2	11991
GSTZ1	12100
PDHB	12102
HAGH	13107
BSG	13114

---

Cellular response to starvation

Cellular response to starvation

	1
set	Cellular response to starvation
setSize	150
pANOVA	1.31e-07
s.dist	0.249
p.adjustANOVA	6.27e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP6V0E2	14382
RPS26	14272
RPL38	14260
ITFG2	14170
RPL14	14132
RPL4	14123
RPL37	14104
ATP6V1B1	14076
RPS24	14036
RPL36A	14005
RPS27L	13997
RPLP1	13982
RPS7	13969
RPS21	13924
RPL23	13870
RPL19	13743
RPS20	13711
RPL31	13670
FAU	13661
RPL35	13541

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP6V0E2	14382
RPS26	14272
RPL38	14260
ITFG2	14170
RPL14	14132
RPL4	14123
RPL37	14104
ATP6V1B1	14076
RPS24	14036
RPL36A	14005
RPS27L	13997
RPLP1	13982
RPS7	13969
RPS21	13924
RPL23	13870
RPL19	13743
RPS20	13711
RPL31	13670
FAU	13661
RPL35	13541
RPL24	13502
RPL27A	13462
RPL29	13346
RPS16	13314
RPL32	13309
RPL35A	13263
RPL34	13258
RPS28	13233
RPLP2	13166
RPL28	13143
RPL13	13079
RPS15	13066
RPL18	12775
RPS15A	12751
RPL12	12724
RPS8	12663
SZT2	12652
RPL36AL	12603
RPL6	12542
RPL5	12514
RPS14	12498
RPL26L1	12460
RPS23	12417
RHEB	12310
ATP6V0E1	12231
RPS19	12149
RPS18	12127
RPL15	12065
RPL36	12034
NPRL2	11951
RPL27	11950
KPTN	11863
LAMTOR5	11854
RPL17	11832
ATP6V1F	11662
CEBPB	11546
RPL9	11494
RPS11	11330
RPL11	11321
RPS25	11285
RPL26	11278
ATP6V1C2	11240
RPSA	11237
RPL39	11179
LAMTOR2	11151
ATF4	11066
ATP6V1G1	10721
RPS27	10602
RPL23A	10245
RPS13	9871
UBA52	9786
RPS4X	9756
RPL30	9205
ATP6V0B	9164
RPL7A	9048
RPS3	9000
ATP6V1G2	8869
RPL37A	8706
WDR59	8301
ATP6V1E2	8294
ASNS	7878
RPL3L	7522
RPL18A	6792
RPS29	6753
RPL22	6396
RPS27A	6354
RPL22L1	6200
RPS6	5666
RPS12	5629
TCIRG1	4524
ATP6V1H	4257
RPTOR	3816
LAMTOR4	3645
LAMTOR3	2552
RRAGB	1276
RPL8	811
DDIT3	214
SESN1	-494
ATP6V1D	-668
RPS10	-1316
ATP6V0C	-1762
RRAGA	-1957
SLC38A9	-2068
MTOR	-2696
RPL10	-2977
RPS9	-3372
ATP6V0D1	-3429
RPL13A	-3557
DEPDC5	-3611
RPS17	-3770
RPL21	-3986
EIF2AK4	-4281
ATF3	-5102
SESN2	-5492
CEBPG	-5623
GCN1	-5695
RPL41	-5741
RPS2	-5778
TRIB3	-5949
RPL3	-6192
ATP6V1E1	-6232
RPLP0	-6241
ATP6V1C1	-6271
RPS3A	-6286
ATP6V0D2	-6431
ATP6V1A	-6438
RPL39L	-7005
IMPACT	-7139
RPS5	-7161
RPL7	-7674
NPRL3	-7694
LAMTOR1	-7765
EIF2S3	-8112
SEH1L	-8530
FNIP2	-8776
MLST8	-8894
BMT2	-9027
MIOS	-9230
RRAGD	-9281
EIF2S2	-9388
RPL10A	-9520
SEC13	-9667
WDR24	-9863
ATF2	-9948
FLCN	-10107
EIF2S1	-10196
FNIP1	-10669
ATP6V1B2	-10962
SH3BP4	-11109
RRAGC	-11118

---

PTEN Regulation

PTEN Regulation

	16
set	PTEN Regulation
setSize	140
pANOVA	1.55e-05
s.dist	-0.211
p.adjustANOVA	4.65e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AGO2	-11303
PSME4	-11301
CSNK2A2	-11291
GATAD2B	-11219
USP7	-11165
TNKS	-11151
CSNK2A1	-11139
RRAGC	-11118
MAPK1	-11072
RCOR1	-11060
REST	-11053
PSMD1	-10774
PSMD2	-10578
VAPA	-10560
GATAD2A	-10449
TNRC6B	-10436
MAPK3	-10415
OTUD3	-10374
AGO3	-10305
KDM1A	-10261

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AGO2	-11303
PSME4	-11301
CSNK2A2	-11291
GATAD2B	-11219
USP7	-11165
TNKS	-11151
CSNK2A1	-11139
RRAGC	-11118
MAPK1	-11072
RCOR1	-11060
REST	-11053
PSMD1	-10774
PSMD2	-10578
VAPA	-10560
GATAD2A	-10449
TNRC6B	-10436
MAPK3	-10415
OTUD3	-10374
AGO3	-10305
KDM1A	-10261
EGR1	-10182
PHC3	-10118
AKT3	-10071
HDAC5	-10034
ATF2	-9948
TRIM27	-9932
RNF2	-9912
TNKS2	-9768
PSMD5	-9639
CHD4	-9630
PSMA7	-9572
CNOT6L	-9450
PTEN	-9332
RRAGD	-9281
BMI1	-9203
MLST8	-8894
HDAC2	-8689
XIAP	-8268
PSMD8	-8234
CHD3	-7850
LAMTOR1	-7765
AGO1	-7708
PML	-7513
SNAI2	-7498
RBBP7	-7329
PSMD11	-7262
STUB1	-7171
HDAC7	-6933
PSMD3	-6784
PSMD7	-6724
USP13	-6703
PSMF1	-6496
ATN1	-6478
PSMD14	-6454
CBX6	-6314
SUZ12	-6219
TNRC6C	-6209
MAF1	-6138
PSMD9	-5996
EED	-5901
UBC	-5726
RBBP4	-5649
PSMB5	-5610
PHC2	-5544
AGO4	-5344
PSMC6	-5093
PSMA2	-4934
PSMC1	-4769
MTA2	-4715
PSMD10	-4579
TNRC6A	-4569
SNAI1	-4563
CBX4	-4411
PTENP1	-3981
HDAC3	-3717
NEDD4	-3421
AKT1	-2828
PSMA1	-2803
PSMB8	-2751
MTOR	-2696
CBX2	-2506
SLC38A9	-2068
RRAGA	-1957
PSMB9	-1918
PSMA4	-1882
PSME3	-1302
NR2E1	-1229
MKRN1	-697
MECOM	428
FRK	507
RNF146	1254
RRAGB	1276
PSMA5	2031
LAMTOR3	2552
WWP2	3525
LAMTOR4	3645
PSME1	3679
RPTOR	3816
PSMA6	3954
PSMC2	4107
PREX2	6106
RPS27A	6354
PSMB2	6521
PSMB6	6672
MTA1	8209
PSMD12	8380
CSNK2B	8404
SCMH1	8779
PHC1	8867
TP53	9538
UBA52	9786
MTA3	10085
AKT2	10214
RING1	10388
UBB	10720
HDAC1	10825
PSMD6	10993
LAMTOR2	11151
PSMB7	11265
PSMD13	11600
PSMB1	11718
MBD3	11816
LAMTOR5	11854
MOV10	11874
PSMD4	11922
CBX8	12049
JUN	12069
RHEB	12310
PSMC4	12403
PSMC3	13023
PSMC5	13027
PSMB10	13272
SALL4	13404
PSMA3	13424
SEM1	13753
PSME2	13821
PSMB4	13948
PSMB3	14313
EZH2	14319
PPARG	14469

---

Mitochondrial biogenesis

Mitochondrial biogenesis

	7
set	Mitochondrial biogenesis
setSize	91
pANOVA	0.000807
s.dist	-0.203
p.adjustANOVA	0.00194

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKAB2	-11222
PPARA	-11218
SOD2	-11114
HELZ2	-11079
CREBBP	-10976
CRTC3	-10755
NCOA2	-10725
GLUD1	-10693
CARM1	-10579
PPARGC1B	-10352
MED1	-10330
MEF2D	-10119
ALAS1	-10083
IDH2	-10005
ATF2	-9948
ATP5F1B	-9680
APOOL	-9629
TFB2M	-9508
MAPK14	-9489
SAMM50	-9329

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKAB2	-11222
PPARA	-11218
SOD2	-11114
HELZ2	-11079
CREBBP	-10976
CRTC3	-10755
NCOA2	-10725
GLUD1	-10693
CARM1	-10579
PPARGC1B	-10352
MED1	-10330
MEF2D	-10119
ALAS1	-10083
IDH2	-10005
ATF2	-9948
ATP5F1B	-9680
APOOL	-9629
TFB2M	-9508
MAPK14	-9489
SAMM50	-9329
TBL1X	-9308
GABPA	-9206
PPRC1	-9083
TFB1M	-8957
NR1D1	-8604
TBL1XR1	-8542
TGS1	-8525
PRKAA2	-8432
NCOA6	-8418
RXRA	-8406
NRF1	-8357
HCFC1	-8165
CHD9	-8138
ACSS2	-8089
ATP5F1A	-7964
NCOR1	-7869
PRKAG1	-7825
CREB1	-7787
NCOA1	-7559
ESRRA	-7464
IMMT	-7295
POLRMT	-7294
TMEM11	-6930
PRKAB1	-6643
MEF2C	-6540
TFAM	-6038
CRTC2	-5508
CRTC1	-5328
GLUD2	-5004
CAMK4	-4575
GABPB1	-4543
ATP5PB	-4314
MTX2	-4040
CALM1	-3767
HDAC3	-3717
HSPA9	-3694
CHCHD3	-3115
PRKAG2	-1456
MTERF1	291
CHCHD6	515
PPARGC1A	2853
SIRT5	3941
SIRT4	6934
POLG2	7485
CYCS	8083
MAPK12	8979
SIRT3	9567
ATP5F1E	9900
MAPK11	11137
DMAC2L	11333
APOO	11520
ATP5MC3	11608
DNAJC11	12237
PERM1	12267
ATP5MC2	12496
ATP5PF	13153
ATP5F1C	13210
ATP5PO	13339
MICOS13	13549
MTX1	13754
MT-ATP6	13802
MT-ATP8	13926
ATP5MF	14007
ATP5F1D	14051
SMARCD3	14082
ATP5MG	14131
MICOS10	14144
ATP5ME	14326
ATP5MC1	14370
SSBP1	14389
ATP5PD	14418

---

Gene Silencing by RNA

Gene Silencing by RNA

	4
set	Gene Silencing by RNA
setSize	97
pANOVA	0.000893
s.dist	-0.195
p.adjustANOVA	0.00195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AGO2	-11303
POLR2A	-11253
NUP98	-11021
PRKRA	-10912
NUP160	-10872
XPO5	-10703
NUP155	-10539
NUP153	-10529
H2BC12	-10488
TNRC6B	-10436
NUP54	-10389
AGO3	-10305
NUP58	-10280
POLR2B	-10198
RANBP2	-10008
NUP188	-9926
POM121	-9872
POM121C	-9739
PLD6	-9737
SEC13	-9667

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AGO2	-11303.0
POLR2A	-11253.0
NUP98	-11021.0
PRKRA	-10912.0
NUP160	-10872.0
XPO5	-10703.0
NUP155	-10539.0
NUP153	-10529.0
H2BC12	-10488.0
TNRC6B	-10436.0
NUP54	-10389.0
AGO3	-10305.0
NUP58	-10280.0
POLR2B	-10198.0
RANBP2	-10008.0
NUP188	-9926.0
POM121	-9872.0
POM121C	-9739.0
PLD6	-9737.0
SEC13	-9667.0
NUP88	-8941.0
H2AC6	-8619.0
NDC1	-8603.0
SEH1L	-8530.0
PIWIL4	-8441.0
H2BC15	-8391.0
TSN	-8274.0
IPO8	-7943.0
NUP50	-7884.0
AGO1	-7708.0
POLR2C	-7625.0
NUP62	-7438.0
NUP133	-7431.0
ELAC2	-7408.0
NUP93	-7256.0
DICER1	-7160.0
NUP214	-7091.0
RAE1	-6787.0
H2BC21	-6331.0
TNRC6C	-6209.0
POLR2D	-6089.0
NUP35	-6087.0
H2BC11	-5895.0
H2BC4	-5716.0
AGO4	-5344.0
PIWIL2	-4924.0
POLR2E	-4747.0
TNRC6A	-4569.0
ANG	-4305.0
PIWIL1	-4295.0
TDRKH	-4069.0
TPR	-3082.0
TSNAX	-2564.0
RAN	-2360.0
H2BC5	-2350.0
HSP90AA1	-1503.0
H2AC7	-1104.0
ASZ1	-177.0
MAEL	417.0
H2BC13	825.0
FKBP6	841.0
H2AC18	970.0
NUP43	1238.0
DDX4	1261.0
H3C1	1377.0
H2BC17	2351.0
H2AB1	3505.0
TDRD6	3713.0
BCDIN3D	3967.0
DROSHA	4604.0
POLR2G	5886.0
NUP205	6483.0
H2AC14	6511.0
H3C15	8338.5
H2BC9	9005.0
H2AZ1	9436.0
TARBP2	9639.0
MYBL1	9738.0
H2BU1	9842.0
NUP37	10190.0
NUP42	11098.0
NUP85	11282.0
POLR2F	12398.0
DGCR8	12910.0
AAAS	13068.0
POLR2I	13073.0
H2AZ2	13097.0
NUP107	13454.0
H2AC20	13516.0
POLR2K	13662.0
POLR2J	13673.0
H3-3A	13720.0
POLR2H	13733.0
HENMT1	13849.0
H2AJ	14151.0
POLR2L	14276.0
NUP210	14365.0

---

Mucopolysaccharidoses

Mucopolysaccharidoses

	12
set	Mucopolysaccharidoses
setSize	11
pANOVA	0.3
s.dist	0.181
p.adjustANOVA	0.327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDUA	14092
SGSH	13230
GUSB	11879
NAGLU	11750
GALNS	7874
ARSB	7539
HYAL1	3925
HGSNAT	-2062
GLB1	-7026
IDS	-8195
GNS	-10240

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDUA	14092
SGSH	13230
GUSB	11879
NAGLU	11750
GALNS	7874
ARSB	7539
HYAL1	3925
HGSNAT	-2062
GLB1	-7026
IDS	-8195
GNS	-10240

---

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

	23
set	Signaling by the B Cell Receptor (BCR)
setSize	105
pANOVA	0.00252
s.dist	-0.171
p.adjustANOVA	0.00431

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITPR1	-11467
PSME4	-11301
NFKB1	-11234
RELA	-11143
PSMD1	-10774
FBXW11	-10707
PSMD2	-10578
NCK1	-10455
ITPR3	-10385
NFATC2	-10372
GRB2	-10367
PPP3R1	-10363
REL	-10354
AHCYL1	-10321
ITPR2	-10230
ORAI1	-10191
SOS1	-10061
NFATC1	-10050
NFATC3	-9699
FYN	-9643

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITPR1	-11467
PSME4	-11301
NFKB1	-11234
RELA	-11143
PSMD1	-10774
FBXW11	-10707
PSMD2	-10578
NCK1	-10455
ITPR3	-10385
NFATC2	-10372
GRB2	-10367
PPP3R1	-10363
REL	-10354
AHCYL1	-10321
ITPR2	-10230
ORAI1	-10191
SOS1	-10061
NFATC1	-10050
NFATC3	-9699
FYN	-9643
PSMD5	-9639
PSMA7	-9572
NRAS	-9010
ORAI2	-8947
SKP1	-8899
PPP3CB	-8774
BCL10	-8346
BTRC	-8254
PSMD8	-8234
PIK3CD	-8192
MAP3K7	-7445
PIK3R1	-7281
PSMD11	-7262
SH3KBP1	-6828
PSMD3	-6784
PSMD7	-6724
PSMF1	-6496
PPP3CA	-6485
PSMD14	-6454
NFKBIE	-6173
PSMD9	-5996
CHUK	-5932
MALT1	-5906
UBC	-5726
PSMB5	-5610
TRPC1	-5365
NFKBIA	-5323
PLCG2	-5224
PSMC6	-5093
PSMA2	-4934
PSMC1	-4769
PSMD10	-4579
CALM1	-3767
RASGRP3	-3645
CD79A	-2903
RASGRP1	-2865
BLK	-2860
PSMA1	-2803
PSMB8	-2751
PSMB9	-1918
PSMA4	-1882
PSME3	-1302
CARD11	-942
NFKBIB	315
PIK3AP1	451
BTK	1026
VAV1	1667
PSMA5	2031
PSME1	3679
PSMA6	3954
PSMC2	4107
CD79B	4927
LYN	6229
RPS27A	6354
PSMB2	6521
PSMB6	6672
CD22	6774
PTPN6	7083
CUL1	7527
PSMD12	8380
UBA52	9786
STIM1	9840
IKBKG	10601
UBB	10720
PSMD6	10993
SYK	11228
PSMB7	11265
PSMD13	11600
PSMB1	11718
PSMD4	11922
HRAS	12108
PSMC4	12403
KRAS	12675
IKBKB	12832
PSMC3	13023
PSMC5	13027
PSMB10	13272
FKBP1A	13398
PSMA3	13424
PRKCB	13517
SEM1	13753
PSME2	13821
PSMB4	13948
PPIA	14296
PSMB3	14313

---

Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis

	8
set	Mitochondrial iron-sulfur cluster biogenesis
setSize	13
pANOVA	0.326
s.dist	0.157
p.adjustANOVA	0.341

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC25A28	13291
SLC25A37	13102
FDX2	9333
LYRM4	8804
ISCU	7020
FXN	6125
GLRX5	5591
ISCA2	4124
FDXR	3851
FDX1	-3745
HSCB	-6519
NFS1	-7110
ISCA1	-7271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC25A28	13291
SLC25A37	13102
FDX2	9333
LYRM4	8804
ISCU	7020
FXN	6125
GLRX5	5591
ISCA2	4124
FDXR	3851
FDX1	-3745
HSCB	-6519
NFS1	-7110
ISCA1	-7271

---

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

	6
set	Metabolism of amino acids and derivatives
setSize	342
pANOVA	6.16e-07
s.dist	0.157
p.adjustANOVA	2.11e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NNMT	14542
SERINC2	14537
NQO1	14378
PHGDH	14336
PSMB3	14313
BHMT2	14289
RPS26	14272
RPL38	14260
RPL14	14132
RPL4	14123
RPL37	14104
GAMT	14072
RPS24	14036
RPL36A	14005
RPS27L	13997
RPLP1	13982
PHYKPL	13970
RPS7	13969
PSMB4	13948
PYCR2	13935

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NNMT	14542.0
SERINC2	14537.0
NQO1	14378.0
PHGDH	14336.0
PSMB3	14313.0
BHMT2	14289.0
RPS26	14272.0
RPL38	14260.0
RPL14	14132.0
RPL4	14123.0
RPL37	14104.0
GAMT	14072.0
RPS24	14036.0
RPL36A	14005.0
RPS27L	13997.0
RPLP1	13982.0
PHYKPL	13970.0
RPS7	13969.0
PSMB4	13948.0
PYCR2	13935.0
RPS21	13924.0
ACAD8	13891.0
ASL	13883.0
RPL23	13870.0
CKMT1A	13864.0
PSME2	13821.0
CHDH	13764.0
SEM1	13753.0
CSAD	13752.0
RPL19	13743.0
SHMT1	13731.0
RPS20	13711.0
RPL31	13670.0
FAU	13661.0
SUOX	13581.0
RPL35	13541.0
CBS	13533.0
RPL24	13502.0
RPL27A	13462.0
PSMA3	13424.0
ALDH7A1	13394.0
RPL29	13346.0
RPS16	13314.0
RPL32	13309.0
PSMB10	13272.0
RPL35A	13263.0
RPL34	13258.0
RPS28	13233.0
RPLP2	13166.0
CKB	13165.0
RPL28	13143.0
RPL13	13079.0
SLC25A10	13069.0
RPS15	13066.0
PSMC5	13027.0
PSMC3	13023.0
HSD17B10	12939.0
TST	12858.0
RPL18	12775.0
RPS15A	12751.0
RPL12	12724.0
RPS8	12663.0
SDSL	12629.0
RPL36AL	12603.0
RPL6	12542.0
RPL5	12514.0
RPS14	12498.0
SLC25A13	12485.0
RPL26L1	12460.0
PSPH	12459.0
RPS23	12417.0
PSMC4	12403.0
SARDH	12156.0
RPS19	12149.0
RPS18	12127.0
AMDHD1	12123.0
PDHB	12102.0
GSTZ1	12100.0
OAZ2	12075.0
RPL15	12065.0
RPL36	12034.0
MPST	11995.0
RPL27	11950.0
PSMD4	11922.0
FTCD	11913.0
RIMKLA	11871.0
PCBD1	11849.0
RPL17	11832.0
RIDA	11812.0
PSMB1	11718.0
AADAT	11670.0
HAAO	11652.0
GPT	11639.0
PSMD13	11600.0
RPL9	11494.0
AANAT	11476.0
IVD	11444.0
NMRAL1	11416.0
ASS1	11374.0
RPS11	11330.0
RPL11	11321.0
RPS25	11285.0
RPL26	11278.0
PSMB7	11265.0
PXMP2	11238.0
RPSA	11237.0
RPL39	11179.0
GCDH	11065.0
MARS1	10996.0
PSMD6	10993.0
PSTK	10665.0
TDO2	10606.0
RPS27	10602.0
NAALAD2	10579.0
TPH1	10426.0
BCKDHB	10410.0
GOT2	10312.0
SRM	10309.0
RPL23A	10245.0
PRODH	10169.0
DMGDH	10126.0
SLC25A12	10091.0
AMT	10064.0
GPT2	10040.0
MCCC1	9914.0
RPS13	9871.0
UBA52	9786.0
RPS4X	9756.0
ALDH4A1	9640.0
SLC6A11	9470.0
KMO	9437.0
GLS2	9353.0
RPL30	9205.0
RPL7A	9048.0
ACADSB	9046.0
EEFSEC	9043.0
RPS3	9000.0
OCA2	8995.0
DBH	8919.0
ASRGL1	8837.0
RPL37A	8706.0
HIBADH	8632.0
HYKK	8577.0
TPO	8533.0
GATM	8513.0
MTAP	8504.0
PNMT	8467.0
PSMD12	8380.0
ASNS	7878.0
ADI1	7771.0
TPH2	7609.0
RPL3L	7522.0
PSAT1	7512.0
APIP	7289.0
SLC6A8	7268.0
SLC5A5	7044.0
AUH	6953.0
GOT1	6832.0
RPL18A	6792.0
RPS29	6753.0
UROC1	6741.0
PSMB6	6672.0
IDO1	6624.0
PSMB2	6521.0
RPL22	6396.0
RPS27A	6354.0
RPL22L1	6200.0
HPD	5862.0
HOGA1	5730.0
RPS6	5666.0
IDO2	5645.0
RPS12	5629.0
CARNS1	5541.0
CBSL	5376.0
SEPHS2	5198.0
SDS	5139.0
BHMT	5085.0
AZIN2	5055.0
HGD	5043.0
ASPA	5013.0
CGA	4996.0
PAOX	4560.0
IYD	4502.0
KYNU	4440.0
OAT	4420.0
PSMC2	4107.0
PSMA6	3954.0
MCCC2	3922.0
TAT	3876.5
PSME1	3679.0
GNMT	3203.0
TDH	3175.0
AFMID	2735.0
SECISBP2	2605.0
LIPT2	2593.0
INMT	2308.0
HNMT	2100.0
QDPR	2061.0
PSMA5	2031.0
FAH	1539.0
GCSH	1399.0
CKMT2	931.0
DUOX1	879.0
RPL8	811.0
HAL	785.0
DDO	784.0
AGMAT	640.0
OAZ1	632.0
SLC25A21	264.0
PDHA1	94.0
GRHPR	86.0
DUOX2	18.0
SRR	-60.0
ARG1	-226.0
DCT	-856.0
AHCY	-1055.0
CKM	-1274.0
PIPOX	-1281.0
PSME3	-1302.0
RPS10	-1316.0
GADL1	-1450.0
MRI1	-1611.0
HIBCH	-1664.0
PSMA4	-1882.0
PSMB9	-1918.0
SLC6A12	-2113.0
AIMP2	-2145.0
QARS1	-2213.0
BCAT2	-2371.0
DIO2	-2622.0
SCLY	-2650.0
AGXT	-2654.0
PSMB8	-2751.0
PSMA1	-2803.0
RPL10	-2977.0
NAGS	-2985.0
KYAT1	-3065.0
MAT1A	-3113.0
GCAT	-3334.0
RPS9	-3372.0
RPL13A	-3557.0
GLUL	-3619.0
RPS17	-3770.0
RPL21	-3986.0
CRYM	-4020.0
TMLHE	-4087.0
CTH	-4173.0
OAZ3	-4194.0
SLC25A44	-4265.0
PSMD10	-4579.0
PSMC1	-4769.0
FOLH1	-4931.0
PSMA2	-4934.0
GLUD2	-5004.0
PSMC6	-5093.0
LIPT1	-5313.0
RIMKLB	-5603.0
PSMB5	-5610.0
LIAS	-5690.0
TXN2	-5734.0
RPL41	-5741.0
RPS2	-5778.0
KARS1	-5829.0
PSMD9	-5996.0
AIMP1	-6005.0
ALDH9A1	-6105.0
RPL3	-6192.0
SARS1	-6194.0
RPLP0	-6241.0
RPS3A	-6286.0
SEPSECS	-6367.0
DARS1	-6409.0
PSMD14	-6454.0
GLDC	-6486.0
PSMF1	-6496.0
KYAT3	-6696.0
PSMD7	-6724.0
NDUFAB1	-6736.0
PSMD3	-6784.0
SLC44A1	-6788.0
SLC7A5	-6826.0
CPS1	-6922.0
AASS	-6955.0
RPL39L	-7005.0
PDHX	-7154.0
RPS5	-7161.0
PSMD11	-7262.0
EEF1E1	-7263.0
BCKDK	-7350.0
ENOPH1	-7374.0
PAPSS1	-7516.0
LARS1	-7543.0
SLC3A2	-7659.0
RPL7	-7674.0
SLC36A4	-7760.0
SLC25A15	-7802.0
OGDH	-7841.0
ADO	-7886.0
DHTKD1	-8151.0
DBT	-8181.0
PSMD8	-8234.0
BCKDHA	-8376.0
ACAT1	-8443.0
CARNMT1	-8503.0
DLAT	-8520.0
ECHS1	-8549.0
MTR	-8632.0
NAT8L	-8660.0
SAT1	-8725.0
ALDH6A1	-8740.0
IARS1	-8798.0
ETHE1	-8936.0
PPM1K	-9128.0
MTRR	-9192.0
RARS1	-9327.0
IL4I1	-9342.0
DLD	-9418.0
SMS	-9493.0
RPL10A	-9520.0
PSMA7	-9572.0
BCAT1	-9631.0
PSMD5	-9639.0
PAPSS2	-9878.0
AMD1	-10056.0
PYCR1	-10072.0
SMOX	-10226.0
GLS	-10388.0
EPRS1	-10523.0
DLST	-10558.0
PSMD2	-10578.0
GLUD1	-10693.0
ALDH18A1	-10719.0
PSMD1	-10774.0
AZIN1	-10796.0
GSR	-10847.0
TXNRD1	-10865.0
SERINC1	-11017.0
SERINC3	-11025.0
SERINC5	-11097.0
PSME4	-11301.0
ODC1	-11441.0
ARG2	-11453.0

---

Diseases of carbohydrate metabolism

Diseases of carbohydrate metabolism

	3
set	Diseases of carbohydrate metabolism
setSize	29
pANOVA	0.163
s.dist	0.15
p.adjustANOVA	0.195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDUA	14092
G6PC3	13646
SGSH	13230
DCXR	12772
GAA	12538
GUSB	11879
NAGLU	11750
NHLRC1	10771
UBB	10720
UBA52	9786
GYG2	8985
GALNS	7874
ARSB	7539
RPS27A	6354
PPP1R3C	4067
HYAL1	3925
KHK	3049
SLC37A4	885
TALDO1	753
HGSNAT	-2062

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDUA	14092
G6PC3	13646
SGSH	13230
DCXR	12772
GAA	12538
GUSB	11879
NAGLU	11750
NHLRC1	10771
UBB	10720
UBA52	9786
GYG2	8985
GALNS	7874
ARSB	7539
RPS27A	6354
PPP1R3C	4067
HYAL1	3925
KHK	3049
SLC37A4	885
TALDO1	753
HGSNAT	-2062
RPIA	-4333
EPM2A	-4361
GYG1	-5601
UBC	-5726
GBE1	-6102
GLB1	-7026
IDS	-8195
GYS1	-9848
GNS	-10240

---

Nervous system development

Nervous system development

	13
set	Nervous system development
setSize	527
pANOVA	2.29e-07
s.dist	-0.131
p.adjustANOVA	9.17e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NRP2	-11469
MMP9	-11463
SEMA5A	-11457
ITGA5	-11448
HSPA8	-11392
NUMB	-11386
DLG4	-11364
PAK1	-11332
PSME4	-11301
MYO10	-11300
CSNK2A2	-11291
CYP51A1	-11237
EPHB6	-11224
EPHA4	-11221
HMGCR	-11191
YES1	-11157
CSNK2A1	-11139
TLN1	-11115
SREBF2	-11107
GSPT1	-11106

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NRP2	-11469
MMP9	-11463
SEMA5A	-11457
ITGA5	-11448
HSPA8	-11392
NUMB	-11386
DLG4	-11364
PAK1	-11332
PSME4	-11301
MYO10	-11300
CSNK2A2	-11291
CYP51A1	-11237
EPHB6	-11224
EPHA4	-11221
HMGCR	-11191
YES1	-11157
CSNK2A1	-11139
TLN1	-11115
SREBF2	-11107
GSPT1	-11106
SLIT2	-11082
MAPK1	-11072
SRC	-11039
RELN	-10985
CLTC	-10972
EPHB4	-10939
MYH9	-10920
PRKAR2A	-10897
ARPC1B	-10878
ARPC2	-10871
ITGB1	-10823
VLDLR	-10810
ANK3	-10806
PSMD1	-10774
SDCBP	-10764
EZR	-10735
DLG1	-10670
PIK3CB	-10645
RGMB	-10632
ITGB3	-10603
ROCK1	-10591
PSMD2	-10578
LAMB1	-10545
ITGA10	-10543
GRB10	-10537
FGFR1	-10522
PSEN1	-10495
SEMA7A	-10476
EGFR	-10456
NCK1	-10455
MAPK3	-10415
RPS6KA3	-10402
PRNP	-10398
ITGA2	-10390
PTK2	-10376
GRB2	-10367
YAP1	-10335
UNC5B	-10317
PABPC1	-10283
EPHB2	-10272
MYO9B	-10252
ITSN1	-10235
KALRN	-10192
EFNB2	-10181
TEAD1	-10153
CD24	-10105
SOS1	-10061
IRS2	-10059
FLRT3	-10033
RNPS1	-10010
ITGAV	-9963
MSN	-9951
GSK3B	-9938
PAK2	-9919
MAP2K1	-9906
SIAH2	-9883
RHOA	-9853
ARHGEF12	-9837
ROBO1	-9823
RANBP9	-9814
COL6A3	-9807
EFNB3	-9779
HSP90AB1	-9750
CUL2	-9733
ABL2	-9719
FYN	-9643
PSMD5	-9639
RPS6KA2	-9623
SHC3	-9600
CAP1	-9593
PSMA7	-9572
RDX	-9550
RPL10A	-9520
CASC3	-9499
MAPK14	-9489
GAB2	-9456
PIK3CA	-9420
ACTR3	-9402
FRS2	-9394
MET	-9354
WASL	-9340
RHOC	-9313
SCD5	-9299
PMP22	-9268
CLTA	-9259
SEMA3A	-9253
ETF1	-9215
RASA1	-9197
PTPN11	-9113
CDC42	-9105
EIF4G1	-9102
NRAS	-9010
NTN4	-8987
AP2A1	-8979
PRX	-8959
DOCK1	-8874
NAB1	-8838
ARHGAP35	-8827
UNC5D	-8817
PPP3CB	-8774
NCK2	-8772
PAK4	-8769
HDAC2	-8689
DPYSL3	-8671
CACNB3	-8662
APH1A	-8620
GAB1	-8583
RPS6KA5	-8526
VASP	-8523
AGRN	-8493
ABLIM3	-8411
DCC	-8276
CXCR4	-8253
CLASP2	-8240
PSMD8	-8234
NGEF	-8233
PIK3CD	-8192
ENAH	-8185
ALCAM	-8158
PITPNA	-8154
PFN2	-8122
DPYSL2	-8066
WWTR1	-8042
CDK5R1	-7875
USP33	-7873
CREB1	-7787
CXCL12	-7770
DNM2	-7746
SEMA6D	-7720
SPTBN1	-7687
LAMA2	-7683
VAV2	-7675
RPL7	-7674
SRGAP1	-7640
PTPRA	-7581
ACTR2	-7538
NCBP2	-7497
DAG1	-7489
PIK3R2	-7425
GDNF	-7418
GPC1	-7410
SPTAN1	-7397
AP2B1	-7327
PIK3R1	-7281
SMARCA4	-7270
PSMD11	-7262
DOK1	-7248
NAB2	-7181
UTRN	-7169
RPS5	-7161
PRKACB	-7127
CLTCL1	-7083
NCBP1	-7061
ARPC5	-7057
NRCAM	-7037
EPHB1	-7019
RPL39L	-7005
GSPT2	-6978
L1CAM	-6965
MAPK7	-6939
COL4A4	-6878
DOK5	-6877
SH3KBP1	-6828
SPTBN2	-6817
PSMD3	-6784
PSMD7	-6724
PLXNA2	-6702
CLASP1	-6656
ACTG1	-6634
SDC2	-6599
RGMA	-6539
PSMF1	-6496
PSMD14	-6454
MYH10	-6451
AP2A2	-6429
ARPC1A	-6336
RPS3A	-6286
RPLP0	-6241
DOK4	-6230
RPL3	-6192
SCN1B	-6147
FES	-6121
NRP1	-6060
COL6A1	-6028
PSMD9	-5996
MAPK8	-5947
CACNB4	-5810
PLXNA4	-5783
EIF4A3	-5781
RPS2	-5778
RAC1	-5771
RPL41	-5741
ST8SIA4	-5732
UBC	-5726
PIP5K1C	-5658
ADAM10	-5654
SOS2	-5653
UPF2	-5647
PSMB5	-5610
ERBB2	-5549
CAP2	-5528
DSCAML1	-5507
RRAS	-5423
TRPC1	-5365
DLG3	-5356
EFNA3	-5308
ARHGEF28	-5289
PSPN	-5233
MYH14	-5175
PSMC6	-5093
ABL1	-5092
CRMP1	-4986
PSMA2	-4934
PLXNA3	-4929
TRPC4	-4888
GRB7	-4871
PSMC1	-4769
PSMD10	-4579
SPTBN4	-4578
CNTN6	-4542
SHANK3	-4483
DOK6	-4397
VAV3	-4394
KCNQ3	-4344
GRIN2B	-4291
POU3F2	-4256
SCN3B	-4224
PAK3	-4223
MAP2K2	-4059
CACNA1H	-4022
RPL21	-3986
EPHA5	-3876
COL9A3	-3858
RPS17	-3770
LIMK2	-3749
SHTN1	-3725
GIT1	-3711
ST8SIA2	-3709
CNTNAP1	-3677
COL4A3	-3652
EGR2	-3630
RPL13A	-3557
ROBO2	-3470
CACNA1I	-3403
RPS9	-3372
EFNB1	-3364
EFNA4	-3217
SRGAP3	-3211
TRPC3	-3207
LAMC1	-3124
ARHGAP39	-3081
RPL10	-2977
PSMA1	-2803
PFN1	-2762
PSMB8	-2751
SCN5A	-2679
AP2M1	-2657
MYL6	-2556
NEO1	-2546
EPHA8	-2521
DRP2	-2488
MYL12A	-2453
SCN3A	-2446
ARHGEF7	-2315
ANK2	-2299
PRKCA	-2223
SIAH1	-2142
PLXNC1	-2095
APH1B	-1990
PSMB9	-1918
GFRA1	-1913
PSMA4	-1882
RET	-1671
TRIO	-1592
HSP90AA1	-1503
ARHGEF11	-1474
RND1	-1453
COL6A2	-1347
RPS10	-1316
PSME3	-1302
MBP	-1222
ISL1	-748
SRGAP2	-728
MYH11	-606
ROCK2	-603
DNM3	-503
DPYSL4	-415
SH3GL2	-413
SCN2B	-350
CNTN1	-336
NCAN	12
TIAM1	309
RPL8	811
ARPC4	1090
ANK1	1162
PLCG1	1239
LDB1	1252
PAK6	1398
NFASC	1411
EPHA10	1465
LHX9	1829
RPS6KA6	1858
CD72	1898
PSMA5	2031
GRIN1	2288
SCN7A	2316
SCN2A	2601
PRKCQ	3033
COL9A1	3170
ZSWIM8	3258
RPS6KA4	3300
PSME1	3679
PSMA6	3954
PSMC2	4107
KIF4A	4300
COL6A6	4349
ITGA2B	4408
SPTBN5	4636
NCAM1	4642
EPHA7	4674
SCN1A	4684
SEMA4A	4696
CNTN2	4911
RPS12	5629
RPS6	5666
PLXNB3	5804
SLIT3	6087
PIK3R3	6184
RPL22L1	6200
LYN	6229
RPS27A	6354
EPHB3	6369
RPL22	6396
SCN11A	6406
SCN8A	6428
PSMB2	6521
FARP2	6531
LYPLA2	6544
ABLIM2	6625
PSMB6	6672
RPS29	6753
RPL18A	6792
AKAP5	7015
EFNA1	7200
EFNA2	7207
EPHA1	7267
NRTN	7358
RPL3L	7522
ARTN	7745
EPHA6	7766
POU3F1	7998
PAK5	8211
SEMA4D	8322
PSMD12	8380
PLXND1	8394
CSNK2B	8404
ITGA1	8682
RPL37A	8706
SCN9A	8798
UPF3A	8965
MAPK12	8979
RPS3	9000
RPL7A	9048
SHC1	9147
NTN1	9179
LHX4	9189
UNC5A	9202
RPL30	9205
MMP2	9229
AP2S1	9308
LHX2	9488
CACNB2	9518
CACNA1C	9536
DAB1	9584
RPS4X	9756
UBA52	9786
UNC5C	9795
RPS13	9871
RPL23A	10245
ROBO3	10250
GFRA2	10530
RBM8A	10583
RPS27	10602
UBB	10720
NCSTN	10786
RAP1GAP	10795
MAPK13	10886
PDLIM7	10971
PSMD6	10993
CFL1	11037
SPTB	11059
MAPK11	11137
RPL39	11179
RPSA	11237
PSMB7	11265
RPL26	11278
RPS25	11285
MYL12B	11294
RPL11	11321
RPS11	11330
PRKACA	11346
EFNA5	11369
CLTB	11399
RPL9	11494
NELL2	11540
LIMK1	11543
PSMD13	11600
PLXNB1	11613
SLIT1	11651
ABLIM1	11653
KCNQ2	11682
PSMB1	11718
ADGRV1	11774
LAMA1	11801
ITGA9	11807
RPL17	11832
PSMD4	11922
RPL27	11950
MAGOHB	11966
COL6A5	11983
RPL36	12034
COL4A2	12058
RPL15	12065
HRAS	12108
RPS18	12127
RPS19	12149
PLXNA1	12235
SCN4B	12278
ARPC3	12328
PSMC4	12403
DPYSL5	12405
RPS23	12417
RPL26L1	12460
EVL	12472
RPS14	12498
RPL5	12514
AGAP2	12530
MSI1	12534
RPL6	12542
RPL36AL	12603
ADGRG6	12650
RPS8	12663
KRAS	12675
ACTB	12714
RPL12	12724
RPS15A	12751
COL4A1	12769
RPL18	12775
ELOC	12912
MYL9	12970
PSMC3	13023
PSMC5	13027
RPS15	13066
RPL13	13079
ELOB	13085
RPL28	13143
RPLP2	13166
CACNB1	13223
RPS28	13233
CACNA1G	13244
RPL34	13258
RPL35A	13263
PSMB10	13272
RPL32	13309
RPS16	13314
RPL29	13346
PSEN2	13351
RHOB	13356
PSMA3	13424
UPF3B	13427
RPL27A	13462
RBX1	13484
RPL24	13502
RPL35	13541
FAU	13661
RPL31	13670
RPS20	13711
RPL19	13743
SEM1	13753
HOXA2	13755
GAP43	13757
RPS6KA1	13794
SEMA6A	13817
PSME2	13821
RPL23	13870
CACNA1D	13875
RPS21	13924
MAGOH	13940
PSMB4	13948
COL4A5	13950
RPS7	13969
RPLP1	13982
CDK5	13987
RPS27L	13997
RPL36A	14005
RPS24	14036
EPHA2	14056
RPL37	14104
PSENEN	14114
RPL4	14123
RPL14	14132
RPL38	14260
RPS26	14272
PSMB3	14313
COL9A2	14400
DNM1	14484
CACNA1S	14547

---

Oxidative Stress Induced Senescence

Oxidative Stress Induced Senescence

	15
set	Oxidative Stress Induced Senescence
setSize	83
pANOVA	0.0577
s.dist	-0.12
p.adjustANOVA	0.0769

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	-11072
CDK6	-10936
MAP2K4	-10517
H2BC12	-10488
TNRC6B	-10436
MAPK3	-10415
AGO3	-10305
MAPKAPK3	-10238
PHC3	-10118
RNF2	-9912
MAP2K7	-9756
MINK1	-9610
MAPK14	-9489
BMI1	-9203
H2AC6	-8619
MAP3K5	-8446
H2BC15	-8391
CDKN2C	-8373
MAP4K4	-8242
MAPKAPK2	-7804

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	-11072.0
CDK6	-10936.0
MAP2K4	-10517.0
H2BC12	-10488.0
TNRC6B	-10436.0
MAPK3	-10415.0
AGO3	-10305.0
MAPKAPK3	-10238.0
PHC3	-10118.0
RNF2	-9912.0
MAP2K7	-9756.0
MINK1	-9610.0
MAPK14	-9489.0
BMI1	-9203.0
H2AC6	-8619.0
MAP3K5	-8446.0
H2BC15	-8391.0
CDKN2C	-8373.0
MAP4K4	-8242.0
MAPKAPK2	-7804.0
KDM6B	-7756.0
AGO1	-7708.0
RBBP7	-7329.0
MAPKAPK5	-7315.0
CDKN2D	-6693.0
H2BC21	-6331.0
CBX6	-6314.0
SUZ12	-6219.0
TNRC6C	-6209.0
MAPK8	-5947.0
EED	-5901.0
H2BC11	-5895.0
MAP2K3	-5836.0
UBC	-5726.0
H2BC4	-5716.0
RBBP4	-5649.0
MAPK9	-5638.0
PHC2	-5544.0
MDM2	-5406.0
AGO4	-5344.0
TNRC6A	-4569.0
CBX4	-4411.0
E2F3	-3623.0
FOS	-3591.0
CBX2	-2506.0
H2BC5	-2350.0
H2AC7	-1104.0
TFDP1	662.0
H2BC13	825.0
H2AC18	970.0
H3C1	1377.0
H2BC17	2351.0
H2AB1	3505.0
TNIK	4714.0
RPS27A	6354.0
H2AC14	6511.0
H3C15	8338.5
SCMH1	8779.0
PHC1	8867.0
H2BC9	9005.0
H2AZ1	9436.0
TP53	9538.0
UBA52	9786.0
H2BU1	9842.0
MDM4	10162.0
RING1	10388.0
CDK4	10547.0
UBB	10720.0
MAPK11	11137.0
MAPK10	11404.0
MOV10	11874.0
MAP2K6	11947.0
CBX8	12049.0
JUN	12069.0
TFDP2	12990.0
H2AZ2	13097.0
H2AC20	13516.0
H3-3A	13720.0
TXN	13915.0
E2F2	13923.0
H2AJ	14151.0
EZH2	14319.0
E2F1	14328.0

---

Mitochondrial protein import

Mitochondrial protein import

	9
set	Mitochondrial protein import
setSize	64
pANOVA	0.17
s.dist	0.099
p.adjustANOVA	0.195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COX17	14508
ATP5MC1	14370
NDUFB8	14309
CHCHD10	14232
DNAJC19	13858
TAZ	13790
MTX1	13754
TIMM8B	13682
TIMM13	13187
PAM16	12869
TOMM40	12491
SLC25A13	12485
TIMM10	12441
CHCHD7	12307
COQ2	11722
TIMM23	11442
TOMM5	11112
SLC25A12	10091
CMC2	9970
COA6	9480

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COX17	14508
ATP5MC1	14370
NDUFB8	14309
CHCHD10	14232
DNAJC19	13858
TAZ	13790
MTX1	13754
TIMM8B	13682
TIMM13	13187
PAM16	12869
TOMM40	12491
SLC25A13	12485
TIMM10	12441
CHCHD7	12307
COQ2	11722
TIMM23	11442
TOMM5	11112
SLC25A12	10091
CMC2	9970
COA6	9480
TIMM50	9429
LDHD	8303
IDH3G	8297
TIMM10B	8117
TIMM17B	7762
COA4	7301
VDAC1	6976
PMPCA	6640
TIMM22	6172
FXN	6125
COX19	6070
CHCHD5	4204
TIMM9	3243
TIMM44	2341
CMC4	392
TIMM8A	19
TOMM6	-325
SLC25A4	-1208
CHCHD4	-1398
TIMM21	-1812
GRPEL1	-2387
SLC25A6	-2631
CHCHD3	-3115
HSPA9	-3694
BCS1L	-3744
MTX2	-4040
CYC1	-4267
ACO2	-4725
TOMM7	-4735
CHCHD2	-5546
GFER	-5708
TOMM22	-5917
HSCB	-6519
GRPEL2	-6795
ATP5F1A	-7964
TIMM17A	-8415
PMPCB	-8634
TOMM70	-9207
SAMM50	-9329
PITRM1	-9480
ATP5F1B	-9680
TOMM20	-10251
HSPD1	-10401
CS	-10726

---

Metabolism

Metabolism

	5
set	Metabolism
setSize	1885
pANOVA	0.00544
s.dist	-0.0384
p.adjustANOVA	0.00816

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HAS2	-11468
ITPR1	-11467
ARG2	-11453
HS3ST3B1	-11452
ODC1	-11441
SEC24D	-11428
SLC2A3	-11421
OSBP	-11418
IQGAP1	-11397
PPP2R5D	-11385
ST3GAL6	-11373
NCOA3	-11372
PLEKHA2	-11369
LRP12	-11355
PRSS3	-11344
MTMR12	-11333
CA9	-11306
PSME4	-11301
PYGB	-11295
CSNK2A2	-11291

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HAS2	-11468.0
ITPR1	-11467.0
ARG2	-11453.0
HS3ST3B1	-11452.0
ODC1	-11441.0
SEC24D	-11428.0
SLC2A3	-11421.0
OSBP	-11418.0
IQGAP1	-11397.0
PPP2R5D	-11385.0
ST3GAL6	-11373.0
NCOA3	-11372.0
PLEKHA2	-11369.0
LRP12	-11355.0
PRSS3	-11344.0
MTMR12	-11333.0
CA9	-11306.0
PSME4	-11301.0
PYGB	-11295.0
CSNK2A2	-11291.0
B4GALT1	-11280.0
FDFT1	-11243.0
CYP51A1	-11237.0
ADCY7	-11229.0
PRKAB2	-11222.0
PPARA	-11218.0
CPNE3	-11208.0
PGM2L1	-11207.0
CSGALNACT2	-11206.0
PPP2CB	-11199.0
HMGCR	-11191.0
CERS6	-11188.0
GPC6	-11183.0
XYLT1	-11181.0
HS3ST3A1	-11177.0
GK	-11154.0
CSNK2A1	-11139.0
MSMO1	-11135.0
PGM2	-11134.0
SEC24A	-11126.0
ME2	-11120.0
QPRT	-11116.0
PITPNM1	-11108.0
SREBF2	-11107.0
SEC23A	-11101.0
SERINC5	-11097.0
PIKFYVE	-11087.0
LPL	-11086.0
HELZ2	-11079.0
KDSR	-11077.0
PLIN3	-11074.0
SBF2	-11066.0
AGPAT5	-11063.0
CAD	-11056.0
NFYA	-11055.0
BPGM	-11036.0
FUT4	-11035.0
SERINC3	-11025.0
ACSL1	-11024.0
NUP98	-11021.0
SERINC1	-11017.0
TPST2	-11016.0
PLA2G4A	-11011.0
SQLE	-11003.0
CRYL1	-10983.0
DDHD2	-10981.0
DSE	-10980.0
SPHK1	-10977.0
CREBBP	-10976.0
VCAN	-10943.0
SEC24B	-10941.0
SLC16A1	-10918.0
PRKAR2A	-10897.0
SDHA	-10893.0
HMGCS1	-10891.0
NUP160	-10872.0
TXNRD1	-10865.0
GNG12	-10853.0
CSPG4	-10851.0
GSR	-10847.0
EP300	-10826.0
AZIN1	-10796.0
HK2	-10793.0
GNB1	-10778.0
PSMD1	-10774.0
INSIG1	-10758.0
PPAT	-10754.0
GART	-10753.0
UQCRFS1	-10752.0
AGPAT3	-10751.0
PTGS2	-10730.0
CS	-10726.0
NCOA2	-10725.0
ALDH18A1	-10719.0
ACAN	-10715.0
PTGES3	-10708.0
MTF1	-10706.0
PRKD2	-10700.0
GLUD1	-10693.0
RAB14	-10691.0
PNP	-10690.0
CERS2	-10689.0
STXBP1	-10685.0
ARNT	-10672.0
PITPNB	-10671.0
PIK3CB	-10645.0
LDLR	-10631.0
MED14	-10624.0
UGDH	-10623.0
MED13L	-10606.0
PPP1CC	-10604.0
MED13	-10581.0
CARM1	-10579.0
PSMD2	-10578.0
SEC24C	-10574.0
VAPA	-10560.0
SPTLC2	-10559.0
DLST	-10558.0
SC5D	-10552.0
LYPLA1	-10542.0
NUP155	-10539.0
NUP153	-10529.0
NEU3	-10525.0
EPRS1	-10523.0
MDH2	-10507.0
VKORC1L1	-10502.0
SP1	-10487.0
CERT1	-10450.0
CMBL	-10424.0
SAMD8	-10413.0
LRP10	-10404.0
LPIN2	-10393.0
ADA	-10391.0
NUP54	-10389.0
GLS	-10388.0
ITPR3	-10385.0
ELOVL1	-10378.0
MTMR3	-10361.0
ACSL3	-10357.0
PPARGC1B	-10352.0
PNPLA8	-10347.0
HSPG2	-10345.0
MED1	-10330.0
AHCYL1	-10321.0
ESYT1	-10308.0
ITPKC	-10295.0
NUP58	-10280.0
ENTPD3	-10258.0
MMUT	-10249.0
GNS	-10240.0
ITPR2	-10230.0
SMOX	-10226.0
ELOVL5	-10212.0
NUDT11	-10211.0
CHSY1	-10186.0
IDI1	-10184.0
ADIPOR2	-10177.0
UQCRC2	-10163.0
PSAP	-10147.0
DCTD	-10141.0
PFKFB3	-10132.0
SORD	-10127.0
IMPA2	-10087.0
ALAS1	-10083.0
IMPDH2	-10082.0
PYCR1	-10072.0
PDXK	-10070.0
AMD1	-10056.0
GNB2	-10031.0
ABCC1	-10028.0
ACBD5	-10013.0
RANBP2	-10008.0
IDH2	-10005.0
CPOX	-9985.0
SELENOI	-9980.0
MBOAT2	-9975.0
DDHD1	-9969.0
PYGL	-9958.0
CDK8	-9957.0
HS2ST1	-9950.0
CRAT	-9942.0
HACD3	-9941.0
MIGA1	-9939.0
NUP188	-9926.0
ABCA1	-9884.0
PAPSS2	-9878.0
POM121	-9872.0
GNAI1	-9859.0
GYS1	-9848.0
CNDP2	-9841.0
OSBPL8	-9817.0
FASN	-9806.0
PPM1L	-9796.0
COX10	-9792.0
MMADHC	-9787.0
AK5	-9772.0
CEMIP	-9771.0
MTMR9	-9769.0
PRKD3	-9767.0
PNPLA3	-9765.0
HSP90AB1	-9750.0
POM121C	-9739.0
PLD6	-9737.0
RXRB	-9727.0
PGK1	-9725.0
B4GALT6	-9720.0
GPHN	-9718.0
MTMR6	-9692.0
CHPF	-9687.0
PRPS2	-9686.0
ATP5F1B	-9680.0
SEC13	-9667.0
ACLY	-9661.0
MTMR2	-9653.0
CHST3	-9649.0
PDK1	-9644.0
ABHD10	-9640.0
PSMD5	-9639.0
BCAT1	-9631.0
DCK	-9618.0
ADCY2	-9606.0
GNPDA1	-9602.0
GNB4	-9589.0
SPTLC1	-9583.0
ADCY9	-9575.0
PSMA7	-9572.0
CLOCK	-9564.0
SLC25A32	-9556.0
SGPL1	-9555.0
PLEKHA1	-9553.0
PGAM1	-9545.0
VAC14	-9543.0
RAB5A	-9531.0
HK1	-9529.0
PGM1	-9523.0
LRPPRC	-9521.0
RPL10A	-9520.0
HSD17B12	-9511.0
PI4KB	-9496.0
SMS	-9493.0
SCO1	-9463.0
LPIN1	-9442.0
PIK3CA	-9420.0
DLD	-9418.0
CTPS2	-9416.0
SLC19A2	-9407.0
PLEKHA5	-9391.0
ALDOC	-9383.0
NDST2	-9377.0
NNT	-9376.0
RAPGEF3	-9356.0
MTHFD1L	-9353.0
TNFAIP8L1	-9350.0
IL4I1	-9342.0
WASL	-9340.0
PTEN	-9332.0
RARS1	-9327.0
CERK	-9326.0
TBL1X	-9308.0
SCD5	-9299.0
SGMS1	-9297.0
ARSJ	-9285.0
SHPK	-9278.0
NDST1	-9270.0
MTHFD2	-9267.0
SRD5A3	-9265.0
FUT10	-9255.0
GNA11	-9252.0
LCLAT1	-9226.0
NUDT4	-9217.0
PDP2	-9195.0
MTRR	-9192.0
CYP1B1	-9182.0
B4GALT3	-9181.0
PIK3C2A	-9163.0
PLEKHA3	-9139.0
PPM1K	-9128.0
PLA2G5	-9127.0
ESYT2	-9124.0
CES2	-9107.0
PFKM	-9104.0
COQ10B	-9098.0
CHST6	-9095.0
GLCE	-9094.0
PFKP	-9078.0
PIK3C3	-9077.0
GCLM	-9063.0
NAMPT	-9049.0
ECI2	-9028.0
TRAP1	-9012.0
MBTPS2	-9007.0
PFKL	-9005.0
INPP4A	-8977.0
LMBRD1	-8965.0
ATIC	-8945.0
NUP88	-8941.0
ETHE1	-8936.0
NDUFS2	-8924.0
AMPD2	-8923.0
ALDOA	-8915.0
ADPRM	-8909.0
PRKAR1A	-8908.0
PAICS	-8895.0
HACD2	-8893.0
ADCY3	-8892.0
ENTPD7	-8888.0
NDUFS1	-8887.0
SIN3A	-8872.0
PLD2	-8858.0
ITPKA	-8851.0
SLC26A2	-8845.0
GCLC	-8844.0
PPP1CB	-8835.0
MTMR4	-8826.0
PLEKHA8	-8823.0
IARS1	-8798.0
MMAA	-8795.0
SCD	-8790.0
GNAQ	-8754.0
UST	-8743.0
ALDH6A1	-8740.0
SUCLG2	-8734.0
SAT1	-8725.0
NADK2	-8711.0
PPARD	-8706.0
ITPKB	-8704.0
GPI	-8682.0
DHCR7	-8679.0
LTA4H	-8669.0
CACNB3	-8662.0
NAT8L	-8660.0
MAN2B1	-8659.0
TNFRSF21	-8645.0
LDHA	-8640.0
MTR	-8632.0
MAT2B	-8624.0
PTDSS1	-8621.0
PDK3	-8617.0
NR1D1	-8604.0
NDC1	-8603.0
OCRL	-8600.0
GPAT4	-8588.0
CAV1	-8579.0
CHST2	-8569.0
CEPT1	-8551.0
ECHS1	-8549.0
TBL1XR1	-8542.0
CD44	-8541.0
CMPK1	-8535.0
DCTPP1	-8531.0
SEH1L	-8530.0
COX7A2L	-8528.0
SYT5	-8527.0
TGS1	-8525.0
DLAT	-8520.0
ST6GALNAC6	-8510.0
INPP5F	-8508.0
CARNMT1	-8503.0
HMOX1	-8495.0
AGRN	-8493.0
ACAT1	-8443.0
SMPD1	-8440.0
CA2	-8438.0
PRKAA2	-8432.0
RDH11	-8431.0
MED17	-8429.0
STARD10	-8425.0
UBIAD1	-8420.0
NCOA6	-8418.0
RXRA	-8406.0
PANK3	-8384.0
BCKDHA	-8376.0
PPIP5K2	-8368.0
NRF1	-8357.0
KPNB1	-8336.0
MFSD2A	-8329.0
DDAH1	-8284.0
GPAT3	-8280.0
B3GNT2	-8278.0
SACM1L	-8271.0
SBF1	-8246.0
NUDT3	-8243.0
ETFB	-8235.0
PSMD8	-8234.0
ACSL4	-8220.0
B4GALT4	-8218.0
ST3GAL1	-8208.0
PDPR	-8207.0
IDS	-8195.0
MED21	-8193.0
PIK3CD	-8192.0
NT5C3A	-8186.0
DBT	-8181.0
B4GALT2	-8172.0
OSBPL6	-8171.0
RORA	-8157.0
TNFAIP8	-8155.0
DHTKD1	-8151.0
LSS	-8144.0
CHD9	-8138.0
SGPP1	-8137.0
INPP5A	-8132.0
CCNC	-8123.0
OSBPL5	-8117.0
L2HGDH	-8114.0
STARD7	-8107.0
MARCKS	-8100.0
CDIPT	-8096.0
ACSS2	-8089.0
PI4K2A	-8075.0
CDK19	-8073.0
POR	-8041.0
HADHB	-8019.0
HSD3B7	-8010.0
PIP4K2C	-8006.0
PNPLA6	-8005.0
MED10	-8004.0
GNG2	-7993.0
OSBPL1A	-7976.0
ATP5F1A	-7964.0
IPMK	-7952.0
CRLS1	-7928.0
MED20	-7887.0
ADO	-7886.0
NUP50	-7884.0
DSEL	-7880.0
PIP5K1A	-7879.0
NCOR1	-7869.0
HS6ST1	-7863.0
AMACR	-7855.0
OGDH	-7841.0
ACAT2	-7836.0
RETSAT	-7834.0
SLC35B2	-7821.0
ACOX3	-7818.0
MED26	-7807.0
MAPKAPK2	-7804.0
SLC25A15	-7802.0
AOC2	-7775.0
LRP8	-7768.0
SLC36A4	-7760.0
DNM2	-7746.0
SLC35D1	-7745.0
ABCB7	-7741.0
MTM1	-7734.0
ETFA	-7730.0
RPL7	-7674.0
ARF1	-7673.0
ADK	-7670.0
SLC3A2	-7659.0
PRPS1	-7649.0
TSPO	-7646.0
AKR7A2	-7645.0
CYB5R3	-7614.0
PANK1	-7612.0
CPT2	-7610.0
STARD4	-7606.0
FUT11	-7589.0
PLCH2	-7584.0
NCOA1	-7559.0
CHSY3	-7557.0
PISD	-7556.0
HSD17B11	-7553.0
PHKA1	-7548.0
LARS1	-7543.0
GNPDA2	-7531.0
ADCY6	-7529.0
PAPSS1	-7516.0
SDHD	-7510.0
ETNK2	-7503.0
ABHD4	-7493.0
PRKAR2B	-7491.0
MVD	-7490.0
LRP1	-7471.0
ESRRA	-7464.0
COX15	-7462.0
RRM2B	-7442.0
NUP62	-7438.0
NUP133	-7431.0
PIK3R2	-7425.0
GPC1	-7410.0
DGAT2	-7406.0
SLC35B3	-7381.0
ADRA2A	-7375.0
ENOPH1	-7374.0
LGMN	-7355.0
BCKDK	-7350.0
PPP2R1A	-7348.0
IMPDH1	-7343.0
OSBPL9	-7319.0
ARNT2	-7318.0
PPP2CA	-7314.0
BPNT2	-7291.0
MTHFR	-7286.0
PIK3R1	-7281.0
OSBPL2	-7280.0
ISCA1	-7271.0
MED23	-7268.0
EEF1E1	-7263.0
PSMD11	-7262.0
AGPAT4	-7257.0
NUP93	-7256.0
IDH3A	-7252.0
PI4K2B	-7236.0
GMPS	-7233.0
HLCS	-7230.0
IP6K1	-7213.0
SLC25A17	-7202.0
ALDH1L2	-7187.0
SRD5A1	-7164.0
LPCAT2	-7162.0
RPS5	-7161.0
PDHX	-7154.0
B4GALNT2	-7144.0
SYNJ1	-7131.0
EHHADH	-7129.0
PRKACB	-7127.0
CA14	-7119.0
HMOX2	-7118.0
TPST1	-7115.0
TKT	-7111.0
NFS1	-7110.0
SDC4	-7098.0
FABP3	-7094.0
NUP214	-7091.0
OSBPL10	-7080.0
GLB1	-7026.0
GPD2	-7016.0
XDH	-7009.0
RPL39L	-7005.0
CBR4	-6992.0
UPP1	-6991.0
INPPL1	-6979.0
PIK3R4	-6977.0
INSIG2	-6961.0
AASS	-6955.0
MBOAT7	-6934.0
GALK1	-6924.0
CPS1	-6922.0
PIAS4	-6919.0
ADCY1	-6864.0
ELOVL4	-6838.0
SLC7A5	-6826.0
SLC44A1	-6788.0
RAE1	-6787.0
NUDT10	-6785.0
PSMD3	-6784.0
AASDHPPT	-6762.0
AKR1C1	-6748.0
NDUFAB1	-6736.0
ACOX1	-6727.0
PSMD7	-6724.0
KYAT3	-6696.0
ARSK	-6682.0
PLA2G15	-6678.0
SLC52A2	-6676.0
SUCLA2	-6659.0
MBOAT1	-6653.0
ENO2	-6610.0
SDC2	-6599.0
MINPP1	-6598.0
AOC3	-6571.0
AMN	-6551.0
HSCB	-6519.0
ST3GAL3	-6518.0
PIP4K2A	-6515.0
PSMF1	-6496.0
UBE2I	-6492.0
GLDC	-6486.0
RRM1	-6461.0
PDSS2	-6458.0
PSMD14	-6454.0
RFK	-6448.0
DARS1	-6409.0
THRAP3	-6402.0
EXT2	-6400.0
PLPP1	-6387.0
SEPSECS	-6367.0
ADH5	-6365.0
ETNK1	-6364.0
MANBA	-6357.0
ARSI	-6350.0
UGCG	-6328.0
CA5B	-6319.0
PRKD1	-6309.0
IMPA1	-6300.0
HPSE	-6291.0
ADIPOR1	-6287.0
RPS3A	-6286.0
NDUFA10	-6273.0
PLPP3	-6269.0
NEU1	-6268.0
LPGAT1	-6263.0
HTD2	-6260.0
IDH1	-6246.0
LPCAT4	-6245.0
RPLP0	-6241.0
ME1	-6239.0
GNG11	-6235.0
GDE1	-6206.0
SARS1	-6194.0
RPL3	-6192.0
CERS4	-6190.0
MED15	-6176.0
CIAPIN1	-6159.0
RPE	-6149.0
PGS1	-6135.0
NT5E	-6126.0
FITM2	-6124.0
ST3GAL2	-6116.0
ALDH9A1	-6105.0
GBE1	-6102.0
ABHD5	-6092.0
NUBPL	-6091.0
NUP35	-6087.0
SLC27A1	-6076.0
SLC37A1	-6068.0
VAPB	-6053.0
CHST11	-6047.0
MID1IP1	-6046.0
RAP1A	-6032.0
ARF3	-6010.0
AIMP1	-6005.0
MMS19	-5998.0
PSMD9	-5996.0
MAOA	-5971.0
AACS	-5966.0
CSNK1G2	-5965.0
LPCAT1	-5958.0
TRIB3	-5949.0
MED19	-5934.0
HMGCL	-5915.0
HSD17B2	-5909.0
PITPNM2	-5889.0
DDAH2	-5883.0
COX18	-5882.0
FAM120B	-5879.0
SGMS2	-5862.0
ACOX2	-5861.0
ESD	-5849.0
CYP24A1	-5848.0
AOX1	-5832.0
KARS1	-5829.0
NDUFB5	-5794.0
RPS2	-5778.0
PNPLA2	-5775.0
ACER2	-5750.0
RPL41	-5741.0
LBR	-5735.0
TXN2	-5734.0
UBC	-5726.0
LIAS	-5690.0
PIP5K1C	-5658.0
PSMB5	-5610.0
CERS5	-5606.0
RIMKLB	-5603.0
GYG1	-5601.0
MED12	-5595.0
G6PD	-5569.0
GLO1	-5553.0
AKR1A1	-5536.0
OSBPL3	-5487.0
MED9	-5481.0
PIP5K1B	-5475.0
FADS1	-5460.0
B3GALT1	-5438.0
TPMT	-5436.0
GPAM	-5433.0
AHRR	-5415.0
CHST7	-5403.0
CPT1A	-5402.0
ENO1	-5385.0
KCNJ11	-5377.0
TCN2	-5375.0
ST3GAL4	-5372.0
PKM	-5363.0
PPA1	-5354.0
PTGS1	-5326.0
PANK4	-5319.0
GPC4	-5317.0
LIPT1	-5313.0
AHR	-5306.0
AKR1C3	-5292.0
IDH3B	-5279.0
MED29	-5267.0
CHPT1	-5261.0
MED8	-5227.0
PLCG2	-5224.0
DHFR2	-5223.0
GDPD5	-5213.0
ENPP1	-5209.0
OXCT1	-5208.0
HADHA	-5205.0
MED16	-5168.0
CYP27A1	-5167.0
ERCC2	-5162.0
PCYT1A	-5159.0
SLC5A6	-5156.0
ACER3	-5125.0
NUDT19	-5114.0
TIAM2	-5097.0
PSMC6	-5093.0
MCEE	-5074.0
MCAT	-5065.0
TPI1	-5035.0
CHP1	-5006.0
GLUD2	-5004.0
VKORC1	-5002.0
PCCB	-4983.0
PSMA2	-4934.0
FOLH1	-4931.0
PLCB3	-4922.0
PLA2G12A	-4921.0
PLCH1	-4912.0
FAR1	-4887.0
ORMDL1	-4866.0
PGD	-4850.0
ACACA	-4843.0
SLC44A5	-4835.0
GSTA4	-4829.0
CBR1	-4825.0
SULT1B1	-4815.0
ELOVL7	-4809.0
AGPS	-4787.0
ACOT7	-4780.0
PSMC1	-4769.0
ALDH3A2	-4746.0
UGP2	-4738.0
ACO2	-4725.0
TMEM186	-4724.0
FUT5	-4713.0
SCO2	-4707.0
FHL2	-4700.0
PARP10	-4674.0
UCK2	-4669.0
APOA5	-4658.0
EBP	-4655.0
MLX	-4648.0
PARP16	-4647.0
FUT3	-4646.0
ALDH1B1	-4633.0
ARNTL	-4624.0
THEM5	-4619.0
CDS1	-4605.0
PSMD10	-4579.0
SUMO2	-4555.0
SLC23A2	-4521.0
ADSL	-4520.0
PUDP	-4498.0
INPP5E	-4476.0
PIK3C2B	-4439.0
PLPP6	-4431.0
PPA2	-4422.0
GNAI2	-4371.0
EPM2A	-4361.0
RPIA	-4333.0
ATP5PB	-4314.0
NUDT7	-4303.0
STX1A	-4270.0
CYC1	-4267.0
SLC25A44	-4265.0
GGPS1	-4254.0
PLAAT1	-4217.0
RHCE	-4204.0
OAZ3	-4194.0
HSD3B1	-4178.0
CTH	-4173.0
GUK1	-4168.0
GPCPD1	-4156.0
ME3	-4136.0
GPC2	-4110.0
ASAH2	-4093.0
TMLHE	-4087.0
DCN	-4034.0
CYSLTR2	-4029.0
CRYM	-4020.0
MORC2	-3999.0
RPL21	-3986.0
GDPD1	-3975.0
PTGIS	-3939.0
IPPK	-3936.0
DTYMK	-3919.0
PRSS1	-3856.0
UMPS	-3798.0
AKR1C2	-3789.0
HAS3	-3787.0
RPS17	-3770.0
CALM1	-3767.0
GCH1	-3759.0
PPP2R1B	-3752.0
FDX1	-3745.0
HDAC3	-3717.0
HACL1	-3713.0
HSD17B7	-3705.0
XYLT2	-3695.0
EXT1	-3686.0
HSD3B2	-3672.0
GLUL	-3619.0
SPHK2	-3604.0
ALOXE3	-3595.0
RPL13A	-3557.0
PC	-3536.0
SCAP	-3483.0
BPNT1	-3480.0
GLTP	-3474.0
FAR2	-3438.0
SMPD4	-3391.0
RPS9	-3372.0
CSGALNACT1	-3351.0
GCAT	-3334.0
MTMR1	-3303.0
PLCD1	-3296.0
CIAO1	-3286.0
STARD3NL	-3259.0
ZDHHC21	-3251.0
SPTSSA	-3149.0
GSTM3	-3130.0
MAT1A	-3113.0
NCOR2	-3103.0
TPR	-3082.0
PLIN1	-3077.0
ACAA2	-3067.0
KYAT1	-3065.0
STARD3	-3061.0
BLVRB	-3058.0
BTD	-3034.0
B3GALT5	-3028.0
ENTPD4	-2989.0
NAGS	-2985.0
RPL10	-2977.0
CD320	-2963.0
SLC2A1	-2933.0
PEX11A	-2931.0
SLC9A1	-2924.0
DPYD	-2914.0
B3GNT4	-2899.0
CSPG5	-2883.0
NDUFAF4	-2850.0
HS6ST3	-2841.0
AKT1	-2828.0
KCNS3	-2818.0
PIP4K2B	-2814.0
ACOT4	-2807.0
PSMA1	-2803.0
PSMB8	-2751.0
CYP2U1	-2736.0
ARSD	-2727.0
NEU4	-2689.0
NR1H2	-2671.0
PCCA	-2666.0
SYNJ2	-2660.0
PFKFB2	-2658.0
AGXT	-2654.0
SCLY	-2650.0
DIO2	-2622.0
SLC25A20	-2604.0
NT5M	-2535.0
COX11	-2487.0
HEXB	-2485.0
AK6	-2480.0
BCAT2	-2371.0
RAN	-2360.0
SUMF2	-2338.0
SDHC	-2327.0
PDP1	-2326.0
ENTPD1	-2317.0
ABCG2	-2305.0
GDA	-2289.0
SULT2B1	-2255.0
CTRB2	-2234.0
PRKCA	-2223.0
QARS1	-2213.0
AIMP2	-2145.0
SLC6A12	-2113.0
UGT8	-2073.0
PHKA2	-2064.0
RAB4A	-2018.0
GNB5	-2003.0
PRKG2	-1987.0
NT5C1B	-1947.0
PSMB9	-1918.0
PSMA4	-1882.0
CTRB1	-1865.0
FBP2	-1853.0
NUBP2	-1841.0
MED25	-1824.0
PGAM2	-1787.0
PARP4	-1743.0
PIK3CG	-1735.0
CYP27B1	-1675.0
HIBCH	-1664.0
MRI1	-1611.0
TMEM126B	-1581.0
PRKAR1B	-1523.0
HSP90AA1	-1503.0
GSTM5	-1498.0
HPRT1	-1483.0
MTMR10	-1463.0
ACAD10	-1459.0
PRKAG2	-1456.0
GADL1	-1450.0
VNN1	-1437.0
DHCR24	-1410.0
SLC25A1	-1408.0
HADH	-1392.0
PLA2G4C	-1387.0
RPS10	-1316.0
CERS3	-1309.0
PSME3	-1302.0
PIPOX	-1281.0
CKM	-1274.0
ACSM3	-1163.0
PIK3R5	-1126.0
AKR1B15	-1123.0
SMPD2	-1079.0
PLCD3	-1072.0
AHCY	-1055.0
B3GAT1	-997.0
CTPS1	-920.0
HPSE2	-911.0
FAHD1	-910.0
CDS2	-898.0
DCT	-856.0
NMNAT1	-830.0
NOS3	-719.0
MTMR7	-650.0
GAPDH	-641.0
PLCB1	-624.0
CYP2S1	-574.0
EPHX2	-464.0
CYP8B1	-447.0
ACADM	-412.0
ALOX5	-399.0
GNG3	-321.0
SLC19A3	-269.0
CA7	-251.0
SULT1A4	-246.0
SPTSSB	-239.0
ARG1	-226.0
GNA14	-207.0
ACSBG2	-150.0
MED27	-146.0
GLYATL2	-137.0
COX14	-62.0
SRR	-60.0
ALOX12	-52.0
CD38	-2.0
NCAN	12.0
DUOX2	18.0
NFYB	45.0
MVK	51.0
GRHPR	86.0
PDHA1	94.0
CD36	183.0
GDPD3	212.0
SLC25A21	264.0
GNA15	383.0
PPT2	393.0
GCKR	395.0
CYP2B6	433.0
ACSS1	438.0
ADCY4	480.0
SLC35D2	488.0
SLCO1A2	497.0
GNPAT	546.0
ETFDH	569.0
NUDT12	589.0
ORMDL3	610.0
CYP2W1	625.0
HSD17B8	631.0
OAZ1	632.0
AGMAT	640.0
SLC52A1	698.0
INPP5K	731.0
RNLS	746.0
TALDO1	753.0
CYP3A43	757.0
B3GAT2	766.0
DDO	784.0
HAL	785.0
SIN3B	806.0
RPL8	811.0
FIG4	820.0
ABO	864.0
DUOX1	879.0
SLC37A4	885.0
PEMT	894.0
CKMT2	931.0
MTMR14	942.0
SULT1A2	952.0
FECH	955.0
TCN1	956.0
COX20	975.0
LDHB	979.0
AS3MT	984.0
CHAT	1099.0
FABP4	1108.0
SLC22A13	1129.0
PNPLA4	1142.0
GNG10	1158.0
PARP6	1191.0
NUP43	1238.0
PLCG1	1239.0
COQ7	1241.0
FLVCR1	1290.0
MED18	1293.0
PLA2G4F	1299.0
CYP2E1	1378.0
GCSH	1399.0
TTR	1483.0
FAH	1539.0
PI4KA	1574.0
STS	1623.0
RHD	1640.0
PITPNM3	1641.0
PLCD4	1642.0
CTSA	1665.0
PLA1A	1682.0
NUDT18	1685.0
MPC2	1693.0
CACNA1E	1791.0
NEU2	1847.0
PRXL2B	1879.0
ASAH1	1924.0
CYP21A2	1954.0
SLC51B	2000.0
PSMA5	2031.0
UGT1A1	2056.0
SLC51A	2059.0
QDPR	2061.0
HNMT	2100.0
GALC	2130.0
B3GALT4	2145.0
STAR	2176.0
FABP2	2185.0
ENPP3	2222.0
FA2H	2237.5
MIOX	2244.0
INMT	2308.0
APOC2	2321.0
ACSL6	2324.0
CDA	2375.0
GLYATL1	2487.0
STARD6	2488.0
GGT6	2492.0
CA6	2507.0
LDHC	2515.0
FAAH	2526.0
AGPAT1	2591.0
LIPT2	2593.0
NT5C1A	2595.0
SECISBP2	2605.0
BAAT	2665.0
PPT1	2667.0
B3GNT3	2674.0
GCK	2676.0
PARP8	2679.0
ETNPPL	2700.0
GPC5	2723.0
AFMID	2735.0
FITM1	2758.0
ABCB1	2771.0
MED6	2795.0
PPARGC1A	2853.0
ADIPOQ	2898.0
ENPP6	2900.0
SLC22A5	2910.0
MOGAT3	2970.0
GPD1L	3037.0
KHK	3049.0
OMD	3064.0
TDH	3175.0
GPAT2	3176.0
GNMT	3203.0
LDHAL6A	3237.0
AIP	3290.0
HS3ST5	3303.0
SDHB	3363.0
CYP1A2	3364.0
PARP14	3388.0
SLC22A1	3401.0
ALOX15B	3415.0
FUT6	3456.0
FMO3	3524.0
FABP1	3550.0
PLB1	3552.0
ENTPD6	3651.0
PSME1	3679.0
SHMT2	3705.0
SLC44A2	3724.0
NDUFV1	3727.0
B4GALT5	3730.0
FDXR	3851.0
TAT	3876.5
SLC52A3	3881.0
PLD3	3892.0
PTGDS	3918.0
MCCC2	3922.0
HYAL1	3925.0
PSMA6	3954.0
GPX2	3956.0
ADCY5	3970.0
HACD1	3973.0
SPTLC3	4049.0
TIMMDC1	4050.0
PPP1R3C	4067.0
GMPR2	4098.0
PSMC2	4107.0
ISCA2	4124.0
THTPA	4125.0
HMMR	4130.0
GSTT2	4141.0
PLA2G2D	4142.5
FUT9	4167.0
CYP4V2	4186.0
GSTO2	4274.0
SULT2A1	4288.0
SLC16A3	4341.0
IP6K2	4345.0
PLA2G10	4371.5
CYP4F8	4375.0
NDST3	4380.0
OAT	4420.0
SGPP2	4433.0
KYNU	4440.0
IYD	4502.0
CYP19A1	4527.0
PAOX	4560.0
HS3ST6	4572.0
ECSIT	4595.0
PLCE1	4603.0
CYP4B1	4611.0
TYMS	4706.0
CA3	4711.0
CERS1	4807.0
ALOX15	4867.0
PRELP	4939.0
ACSBG1	4946.0
CGA	4996.0
ASPA	5013.0
CYP2C19	5035.0
PYGM	5039.0
HGD	5043.0
AZIN2	5055.0
AGL	5070.0
UQCRC1	5081.0
BHMT	5085.0
SDS	5139.0
FUT1	5141.0
SCP2	5158.0
SEPHS2	5198.0
CHAC2	5253.0
B4GALT7	5275.0
CTRC	5288.0
HACD4	5325.0
ANKRD1	5326.0
ACP5	5359.0
CBSL	5376.0
LHB	5382.0
ACSF3	5432.0
SLC23A1	5475.0
PLA2G4D	5502.0
CARNS1	5541.0
LRAT	5559.0
ACSM2A	5567.0
GLRX5	5591.0
PCTP	5611.0
RPS12	5629.0
IDO2	5645.0
MTHFD1	5665.0
RPS6	5666.0
GLIPR1	5719.0
HOGA1	5730.0
UPB1	5732.0
HPGD	5777.0
NAT1	5812.0
VAMP2	5821.0
CYP4F3	5822.0
GPD1	5824.0
HPD	5862.0
NDUFS4	5902.0
NSDHL	5963.0
STK11	5988.0
NOSTRIN	5995.0
SLC25A19	6051.0
COX19	6070.0
MED30	6103.0
ADH6	6111.0
FXN	6125.0
AGPAT2	6129.0
PIK3R3	6184.0
RPL22L1	6200.0
MOCS3	6206.0
GLP1R	6315.0
CHST1	6320.0
PHOSPHO1	6325.0
ACADS	6332.0
RPS27A	6354.0
CYP26C1	6357.0
PFKFB1	6392.0
RPL22	6396.0
PCK1	6404.0
PANK2	6432.0
XYLB	6477.0
NUP205	6483.0
MED4	6507.0
PSMB2	6521.0
PLCB2	6573.0
IDO1	6624.0
PSMB6	6672.0
LIPH	6706.0
ACY3	6740.0
UROC1	6741.0
CES3	6750.0
RPS29	6753.0
INPP5J	6757.0
RPL18A	6792.0
GOT1	6832.0
AK7	6837.0
LRP2	6838.0
AK4	6948.0
AUH	6953.0
SPR	6968.0
ALDH3B1	6972.0
VDAC1	6976.0
INPP4B	6986.0
AKAP5	7015.0
ISCU	7020.0
ALDH1L1	7036.0
SLC5A5	7044.0
MLYCD	7074.0
MLXIPL	7094.0
TNFAIP8L3	7113.0
ADH1B	7117.0
CYP3A5	7176.0
HSD17B1	7181.0
SLC6A8	7268.0
HSD11B2	7288.0
APIP	7289.0
CYP1A1	7313.0
KCNG2	7318.0
CYP17A1	7348.0
AK8	7372.0
NMNAT2	7409.0
COQ9	7479.0
PSAT1	7512.0
RPL3L	7522.0
ARSB	7539.0
PPP1CA	7553.0
UCK1	7569.0
ACSM2B	7593.0
TPH2	7609.0
SPNS2	7634.0
FPGS	7672.0
ADI1	7771.0
CYP39A1	7845.0
GPX4	7856.0
SULT1A1	7872.0
ASNS	7878.0
SLC26A1	7907.0
HSD17B13	7913.0
GRHL1	7937.0
PTGES	7965.0
MBTPS1	8005.0
FABP6	8018.0
MIGA2	8037.0
CHST5	8056.0
RGL1	8080.0
CYCS	8083.0
GNGT2	8116.0
VNN2	8135.0
SLC44A3	8216.0
ABCC2	8217.0
APOA1	8251.0
PLAAT2	8286.0
IDH3G	8297.0
NUDT15	8344.0
PSMD12	8380.0
CSNK2B	8404.0
ACOT9	8429.0
GM2A	8446.0
PHYH	8462.0
B3GNT7	8463.0
PNMT	8467.0
TPK1	8495.0
MTAP	8504.0
GATM	8513.0
CPNE1	8532.0
TPO	8533.0
MTHFD2L	8558.0
PHKB	8560.0
SDC1	8569.0
HYKK	8577.0
HIBADH	8632.0
KCNB1	8671.0
PTGR1	8681.0
RPL37A	8706.0
NDUFAF5	8736.0
NAPRT	8780.0
AMPD3	8781.0
TTPA	8795.0
LYRM4	8804.0
ALB	8812.0
HSD11B1	8819.0
ASRGL1	8837.0
GNB3	8847.0
DEGS1	8857.0
NDUFAF6	8858.0
COQ10A	8865.0
MTARC2	8879.0
CYP46A1	8912.0
DBH	8919.0
GGT5	8922.0
CYP2D6	8926.0
ELOVL2	8929.0
BST1	8936.0
MTARC1	8969.0
SDC3	8973.0
GYG2	8985.0
LTC4S	8991.0
OCA2	8995.0
RPS3	9000.0
PLD4	9002.0
DERA	9015.0
ENPP2	9032.0
DGAT1	9037.0
EEFSEC	9043.0
ACADSB	9046.0
RPL7A	9048.0
FUT2	9063.0
FDPS	9083.0
MGLL	9097.0
ENTPD5	9102.0
COASY	9113.0
ABCC8	9134.0
BLVRA	9154.0
AKR7A3	9176.0
RPL30	9205.0
PPCS	9206.0
UGT3A2	9218.0
ADHFE1	9248.0
NDUFA5	9255.0
PDK4	9281.0
OXCT2	9309.0
FDX2	9333.0
AGT	9338.0
APOM	9345.0
GLS2	9353.0
LIPE	9381.0
KMO	9437.0
UGT1A7	9456.0
SLC6A11	9470.0
NT5C2	9497.0
CACNB2	9518.0
SERPINA6	9527.0
CACNA1C	9536.0
TKFC	9552.0
ACHE	9574.0
SUMF1	9590.0
NDUFAF1	9621.0
GSTM1	9638.0
ALDH4A1	9640.0
HYAL3	9643.0
PMVK	9661.0
TMEM86B	9701.0
CYP2R1	9728.0
RPS4X	9756.0
INPP1	9758.0
B4GAT1	9776.0
UBA52	9786.0
BDH1	9818.0
NOSIP	9831.0
LPIN3	9832.0
FADS2	9848.0
RPS13	9871.0
AOC1	9873.0
CROT	9884.0
ATP5F1E	9900.0
NMNAT3	9911.0
MCCC1	9914.0
AK9	9948.0
ACOXL	9962.0
COX16	9979.0
ACOT8	10012.0
GPT2	10040.0
RAPGEF4	10046.0
CA12	10053.0
AMT	10064.0
MMACHC	10068.0
HSD17B3	10073.0
ACOT1	10077.0
SLC25A12	10091.0
UCP3	10099.0
CYP2J2	10120.0
DMGDH	10126.0
BCO2	10143.0
PRODH	10169.0
CBR3	10189.0
NUP37	10190.0
NQO2	10207.0
RPL23A	10245.0
NDUFB10	10249.0
CHRM3	10265.0
TACO1	10270.0
NDUFB11	10281.0
NUDT13	10289.0
PHKG1	10295.0
NDUFAF7	10299.0
SRM	10309.0
MECR	10310.0
GOT2	10312.0
STARD5	10323.0
PECR	10326.0
PNPO	10371.0
PLEKHA4	10387.0
MPC1	10400.0
BCKDHB	10410.0
TPH1	10426.0
BPHL	10441.0
PDSS1	10459.0
SLC27A2	10493.0
GGT7	10498.0
SUCLG1	10506.0
PNPLA7	10513.0
D2HGDH	10515.0
SLC25A11	10521.0
CA13	10536.0
AKR7L	10543.0
NAALAD2	10579.0
RPS27	10602.0
TDO2	10606.0
MAOB	10607.0
SAR1B	10611.0
ACSL5	10621.0
NDUFA9	10641.0
ITPK1	10648.0
PSTK	10665.0
COMT	10704.0
UBB	10720.0
BRIP1	10747.0
MAN2B2	10764.0
NHLRC1	10771.0
DECR2	10790.0
ACBD6	10797.0
NAXD	10807.0
CYP26A1	10819.0
FLAD1	10834.0
GSTM2	10837.0
GNG5	10844.0
SULT1A3	10882.0
FH	10893.0
COQ3	10914.0
ELOVL6	10919.0
MOCS1	10957.0
PODXL2	10982.0
PSMD6	10993.0
MARS1	10996.0
GCDH	11065.0
MED22	11092.0
SURF1	11097.0
NUP42	11098.0
NDUFC2	11100.0
CHST9	11178.0
RPL39	11179.0
PTDSS2	11183.0
UQCR11	11196.0
HMBS	11201.0
B3GALNT1	11231.0
RPSA	11237.0
PXMP2	11238.0
SLC19A1	11261.0
ACADL	11262.0
PSMB7	11265.0
RPL26	11278.0
NUP85	11282.0
RPS25	11285.0
GNG7	11286.0
SLC25A14	11287.0
HS6ST2	11301.0
SLC46A1	11310.0
RPL11	11321.0
RPS11	11330.0
DMAC2L	11333.0
NDUFB6	11337.0
PRKACA	11346.0
MAT2A	11362.0
ASS1	11374.0
NMRAL1	11416.0
GSTO1	11421.0
PTPN13	11427.0
SULT4A1	11428.0
INPP5B	11437.0
IVD	11444.0
ENO3	11464.0
AANAT	11476.0
SAMHD1	11482.0
RPL9	11494.0
GGCT	11508.0
SMPD3	11511.0
ABCD1	11554.0
PCYT2	11567.0
NDUFV3	11569.0
PCK2	11580.0
GLB1L	11588.0
PON2	11598.0
PSMD13	11600.0
ATP5MC3	11608.0
MED24	11617.0
GPT	11639.0
HAAO	11652.0
NUDT9	11664.0
ENTPD8	11666.0
AADAT	11670.0
GALT	11675.0
G0S2	11694.0
PSMB1	11718.0
COQ2	11722.0
MGST1	11742.0
CHKA	11745.0
NAGLU	11750.0
DEGS2	11784.0
NAXE	11797.0
MED28	11808.0
RIDA	11812.0
ALOX12B	11815.0
HSD17B14	11818.0
RPL17	11832.0
ACAA1	11834.0
COX5A	11835.0
BCHE	11836.0
ADAL	11842.0
PCBD1	11849.0
CYB5A	11853.0
NDUFS6	11867.0
RIMKLA	11871.0
GUSB	11879.0
COQ5	11897.0
ACACB	11906.0
FTCD	11913.0
PSMD4	11922.0
N6AMT1	11926.0
VDR	11928.0
ACBD7	11939.0
SLC27A5	11940.0
RPL27	11950.0
INPP5D	11988.0
RUFY1	11989.0
PDK2	11991.0
MPST	11995.0
GLA	11996.0
BCAN	12002.0
RBKS	12005.0
HYAL2	12011.0
ABHD3	12013.0
DHODH	12023.0
GSTP1	12024.0
CH25H	12031.0
RPL36	12034.0
ACP6	12041.0
RPL15	12065.0
OAZ2	12075.0
ACADVL	12090.0
GSTZ1	12100.0
PDHB	12102.0
ABCC5	12106.0
NME2	12113.0
CYP11A1	12115.0
AMDHD1	12123.0
RPS18	12127.0
ALDH2	12136.0
RPS19	12149.0
SARDH	12156.0
PARP9	12160.0
BDH2	12168.0
CPNE7	12203.0
MED31	12234.0
ABCB4	12240.0
PLEKHA6	12251.0
DECR1	12262.0
PLCB4	12269.0
MTHFS	12272.0
CIAO3	12274.0
PLA2G6	12281.0
HS3ST4	12288.0
PTS	12302.0
PTGES2	12330.0
GGT1	12331.0
NMRK1	12352.0
PTPMT1	12375.0
PSMC4	12403.0
RPS23	12417.0
POLD1	12427.0
NDUFA6	12455.0
PSPH	12459.0
RPL26L1	12460.0
NDUFS3	12474.0
PHKG2	12482.0
SLC25A13	12485.0
ATP5MC2	12496.0
RPS14	12498.0
PTGR2	12503.0
RPL5	12514.0
MED7	12517.0
UQCRH	12519.0
BGN	12524.0
GAA	12538.0
RPL6	12542.0
SLC27A3	12544.0
GBA2	12555.0
MMAB	12576.0
PLA2R1	12593.0
RPL36AL	12603.0
NME4	12609.0
EPHX1	12613.0
GLYCTK	12614.0
PLD1	12623.0
SDSL	12629.0
NDUFB9	12633.0
RPS8	12663.0
ECI1	12667.0
MOCOS	12669.0
ESYT3	12680.0
GBA	12701.0
GSTM4	12712.0
NDUFS8	12718.0
LHPP	12723.0
RPL12	12724.0
ADPGK	12732.0
NDUFC1	12738.0
NADK	12740.0
ITPA	12745.0
RPS15A	12751.0
COX8A	12759.0
NDUFA4	12760.0
DCXR	12772.0
CIAO2B	12774.0
RPL18	12775.0
ACSF2	12786.0
HSD17B4	12800.0
MDH1	12807.0
CPTP	12847.0
UQCR10	12852.0
NFYC	12856.0
TST	12858.0
MED11	12862.0
NUBP1	12870.0
CHST13	12881.0
OSBPL7	12884.0
DHRS7B	12889.0
MGST3	12935.0
HSD17B10	12939.0
PPOX	12965.0
ACBD4	12972.0
NUDT16	12977.0
PSMC3	13023.0
PSMC5	13027.0
CACNA2D2	13044.0
NDUFB7	13062.0
RPS15	13066.0
AAAS	13068.0
SLC25A10	13069.0
RPL13	13079.0
SLC25A37	13102.0
HAGH	13107.0
NDUFB3	13112.0
BSG	13114.0
GMPR	13120.0
OPLAH	13123.0
ARSG	13137.0
RPL28	13143.0
ATP5PF	13153.0
CKB	13165.0
RPLP2	13166.0
B4GALNT1	13174.0
CYB5B	13185.0
GSTT2B	13191.0
CHST12	13192.0
ACOT2	13195.0
ISYNA1	13197.0
CHAC1	13199.0
ATP5F1C	13210.0
ARV1	13216.0
RRM2	13227.0
SGSH	13230.0
RPS28	13233.0
AK2	13235.0
SREBF1	13240.0
NADSYN1	13251.0
RPL34	13258.0
RPL35A	13263.0
NDUFAF2	13267.0
GPX1	13270.0
PSMB10	13272.0
B3GAT3	13275.0
GSS	13286.0
SLC25A28	13291.0
NME3	13300.0
RPL32	13309.0
B3GALT6	13311.0
RPS16	13314.0
NDUFA8	13317.0
SLC25A16	13324.0
PLPP2	13326.0
GPS2	13332.0
PFAS	13335.0
ATP5PO	13339.0
RPL29	13346.0
ALAD	13359.0
SULT1C2	13390.0
MT-ND6	13393.0
ALDH7A1	13394.0
NUDT1	13415.0
PSMA3	13424.0
NDUFS7	13425.0
NUP107	13454.0
RPL27A	13462.0
UROD	13474.0
COQ6	13489.0
MT-ND5	13494.0
RPL24	13502.0
DNPH1	13518.0
RBP4	13521.0
GNG4	13523.0
CBS	13533.0
ABHD14B	13539.0
RPL35	13541.0
DBI	13547.0
SUOX	13581.0
PLBD1	13591.0
TK2	13616.0
CUBN	13619.0
G6PC3	13646.0
FAU	13661.0
MT-ND1	13666.0
ACSS3	13669.0
RPL31	13670.0
PGLS	13671.0
TYMP	13684.0
ORMDL2	13689.0
NDOR1	13693.0
LPCAT3	13697.0
MT-ND4	13703.0
ABCD4	13709.0
RPS20	13711.0
RBP1	13728.0
SHMT1	13731.0
NT5C	13737.0
RPL19	13743.0
UCKL1	13746.0
CSAD	13752.0
SEM1	13753.0
DGUOK	13761.0
CHDH	13764.0
AK1	13771.0
TAZ	13790.0
ACAD11	13792.0
ACY1	13801.0
MT-ATP6	13802.0
CHPF2	13803.0
PLIN2	13806.0
NDUFA13	13815.0
ARSA	13818.0
SNAP25	13820.0
PSME2	13821.0
CACNA1A	13827.0
PGP	13846.0
CYP26B1	13847.0
CHST15	13853.0
CKMT1A	13864.0
COX7C	13865.0
NR1H3	13867.0
RPL23	13870.0
CACNA1D	13875.0
ASL	13883.0
ACAD8	13891.0
MT-ND2	13898.0
MAN2C1	13903.0
APRT	13905.0
CPT1B	13906.0
TRMT112	13907.0
TXN	13915.0
RPS21	13924.0
MT-ATP8	13926.0
COX6B1	13927.0
PYCR2	13935.0
PPIP5K1	13937.0
PSMB4	13948.0
UQCRB	13949.0
GNAS	13959.0
RPS7	13969.0
PHYKPL	13970.0
TK1	13971.0
NPAS2	13976.0
TM7SF2	13979.0
RPLP1	13982.0
CHST14	13989.0
PDZD11	13996.0
RPS27L	13997.0
RPL36A	14005.0
ATP5MF	14007.0
DUT	14008.0
NUDT5	14009.0
HEXA	14011.0
RPS24	14036.0
AGK	14043.0
ATP5F1D	14051.0
ACOT11	14053.0
COX4I1	14066.0
GAMT	14072.0
COA1	14073.0
SMARCD3	14082.0
CES1	14086.0
IDUA	14092.0
RPL37	14104.0
PPCDC	14121.0
RPL4	14123.0
ATP5MG	14131.0
RPL14	14132.0
UCP2	14136.0
PLAAT4	14146.0
NDUFB2	14156.0
NDUFA11	14169.0
PIK3R6	14180.0
UROS	14191.0
GLRX	14194.0
COX6C	14196.0
NDUFA3	14207.0
TECR	14211.0
AKR1B1	14217.0
RTEL1	14219.0
NDUFB4	14220.0
COX6A1	14228.0
MT-CO2	14237.0
COX5B	14239.0
TBXAS1	14256.0
RPL38	14260.0
MOCS2	14270.0
RPS26	14272.0
NDUFS5	14273.0
MT-ND3	14280.0
ACOT13	14282.0
THEM4	14287.0
BHMT2	14289.0
NDUFA2	14297.0
COX7B	14304.0
NDUFB8	14309.0
NDUFV2	14312.0
PSMB3	14313.0
CHKB	14316.0
ATP5ME	14326.0
SLC25A27	14330.0
PHGDH	14336.0
ABCC3	14337.0
MT-CO1	14342.0
NDUFA12	14348.0
NDUFA1	14353.0
SLC37A2	14357.0
ACAD9	14363.0
NUP210	14365.0
ATP5MC1	14370.0
GSTK1	14371.0
NQO1	14378.0
HILPDA	14385.0
MT-CYB	14392.0
APOE	14414.0
ATP5PD	14418.0
GCHFR	14434.0
PLA2G4B	14436.0
NDUFAF3	14437.0
UQCRQ	14468.0
PPARG	14469.0
FABP5	14477.0
NDUFA7	14483.0
MGST2	14496.0
NDUFB1	14506.0
MT-CO3	14510.0
NME1	14516.0
DHFR	14530.0
PFKFB4	14531.0
SERINC2	14537.0
GALE	14538.0
NNMT	14542.0
CYGB	14543.0
ANGPTL4	14545.0
PLAAT3	14549.0

---

Stabilization of p53

Stabilization of p53

	24
set	Stabilization of p53
setSize	53
pANOVA	0.77
s.dist	0.0232
p.adjustANOVA	0.77

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB3	14313
PSMB4	13948
PSME2	13821
SEM1	13753
PSMA3	13424
PSMB10	13272
PSMC5	13027
PSMC3	13023
PSMC4	12403
PSMD4	11922
PSMB1	11718
PSMD13	11600
PSMB7	11265
PSMD6	10993
UBB	10720
MDM4	10162
UBA52	9786
TP53	9538
PSMD12	8380
PSMB6	6672

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB3	14313
PSMB4	13948
PSME2	13821
SEM1	13753
PSMA3	13424
PSMB10	13272
PSMC5	13027
PSMC3	13023
PSMC4	12403
PSMD4	11922
PSMB1	11718
PSMD13	11600
PSMB7	11265
PSMD6	10993
UBB	10720
MDM4	10162
UBA52	9786
TP53	9538
PSMD12	8380
PSMB6	6672
PSMB2	6521
RPS27A	6354
PSMC2	4107
PSMA6	3954
PSME1	3679
PSMA5	2031
CHEK2	-1275
PSME3	-1302
PSMA4	-1882
PSMB9	-1918
PSMB8	-2751
PSMA1	-2803
PSMD10	-4579
PSMC1	-4769
PSMA2	-4934
PSMC6	-5093
ATM	-5318
MDM2	-5406
PSMB5	-5610
UBC	-5726
PSMD9	-5996
PSMD14	-6454
PSMF1	-6496
PSMD7	-6724
PSMD3	-6784
PSMD11	-7262
PSMD8	-8234
PSMA7	-9572
PHF20	-9616
PSMD5	-9639
PSMD2	-10578
PSMD1	-10774
PSME4	-11301

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.2.2              echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.1               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58                 fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [23] IRanges_2.30.0              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.9                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.7                ggplot2_3.3.6              
## [35] tidyverse_1.3.1             zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.7             polylabelr_0.2.0      
##   [7] splines_4.2.1          BiocParallel_1.30.3    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.3            magrittr_2.0.3        
##  [13] memoise_2.0.1          tzdb_0.3.0             Biostrings_2.64.0     
##  [16] annotate_1.74.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.3             rvest_1.0.2           
##  [22] haven_2.5.0            xfun_0.31              crayon_1.5.1          
##  [25] RCurl_1.98-1.7         jsonlite_1.8.0         genefilter_1.78.0     
##  [28] survival_3.4-0         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.42.0        XVector_0.36.0        
##  [34] webshot_0.5.3          DelayedArray_0.22.0    scales_1.2.0          
##  [37] DBI_1.1.3              Rcpp_1.0.8.3           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.3             RColorBrewer_1.1-3     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.9         
##  [49] XML_3.99-0.10          sass_0.4.1             dbplyr_2.2.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.3            later_1.3.0           
##  [58] AnnotationDbi_1.58.0   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.1            cachem_1.0.6           cli_3.3.0             
##  [64] generics_0.1.2         RSQLite_2.2.14         broom_0.8.0           
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.39             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.36.2        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.1         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.74.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] lattice_0.20-45        Matrix_1.4-1           vctrs_0.4.1           
##  [88] pillar_1.7.0           lifecycle_1.0.1        jquerylib_0.1.4       
##  [91] data.table_1.14.2      bitops_1.0-7           httpuv_1.6.5          
##  [94] R6_2.5.1               promises_1.2.0.1       KernSmooth_2.23-20    
##  [97] gridExtra_2.3          codetools_0.2-18       assertthat_0.2.1      
## [100] withr_2.5.0            GenomeInfoDbData_1.2.8 parallel_4.2.1        
## [103] hms_1.1.1              grid_4.2.1             rmarkdown_2.14        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report