Mitch Report

date generated: 2022-08-23

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   KO        drug
## 5_8S_rRNA -0.4520464  13.3741078
## 7SK       -2.2982399   8.2273400
## A1BG      -3.3008939   6.5685508
## A1BG-AS1   0.3211569   2.0363758
## A1CF      -0.7352419  -0.3352928
## A2M       30.2687300 -19.6839168

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	24473
duplicated_genes_present	0
num_profile_genes_in_sets	8850
num_profile_genes_not_in_sets	15623
profile_pearson_correl	0.06908
profile_spearman_correl	0.09129

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2512
num_genesets_excluded	1047
num_genesets_included	1465

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 928

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 52 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.KO	s.drug	p.KO	p.drug
Peptide chain elongation	87	2.79e-43	3.40e-41	0.830	-0.422	0.715	9.35e-12	8.26e-31
Viral mRNA Translation	87	3.07e-43	3.46e-41	0.830	-0.420	0.715	1.17e-11	7.10e-31
Formation of a pool of free 40S subunits	99	1.26e-44	1.68e-42	0.789	-0.444	0.652	2.03e-14	3.21e-29
Eukaryotic Translation Termination	91	2.19e-41	1.89e-39	0.794	-0.402	0.684	3.27e-11	1.32e-29
Eukaryotic Translation Elongation	92	1.82e-41	1.67e-39	0.790	-0.412	0.674	8.16e-12	4.97e-29
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	1.43e-06	5.93e-06	0.799	0.358	-0.714	2.55e-02	8.23e-06
Defective EXT2 causes exostoses 2	13	1.43e-06	5.93e-06	0.799	0.358	-0.714	2.55e-02	8.23e-06
Laminin interactions	23	1.23e-11	1.39e-10	0.827	0.269	-0.782	2.58e-02	8.23e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	6.60e-41	5.37e-39	0.755	-0.423	0.625	3.36e-13	5.07e-27
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	6.86e-38	4.02e-36	0.749	-0.424	0.617	1.55e-12	6.83e-25
Selenocysteine synthesis	91	1.38e-38	8.77e-37	0.768	-0.355	0.681	4.60e-09	2.66e-29
Formation of the ternary complex, and subsequently, the 43S complex	50	7.28e-20	1.67e-18	0.731	-0.501	0.532	8.83e-10	7.23e-11
Syndecan interactions	19	5.07e-10	4.45e-09	0.844	0.216	-0.816	1.04e-01	7.21e-10
Mucopolysaccharidoses	11	1.36e-05	4.58e-05	0.799	0.756	-0.258	1.41e-05	1.38e-01
Defective B4GALT7 causes EDS, progeroid type	18	1.10e-07	5.83e-07	0.739	0.371	-0.639	6.44e-03	2.71e-06
L13a-mediated translational silencing of Ceruloplasmin expression	109	3.24e-39	2.26e-37	0.702	-0.466	0.525	3.94e-17	2.32e-21
GTP hydrolysis and joining of the 60S ribosomal subunit	110	3.32e-38	2.03e-36	0.690	-0.442	0.530	1.11e-15	6.60e-22
Defective B3GAT3 causes JDSSDHD	18	9.01e-07	3.96e-06	0.687	0.376	-0.575	5.69e-03	2.43e-05
Other semaphorin interactions	15	8.68e-06	3.06e-05	0.689	0.359	-0.588	1.59e-02	7.98e-05
Defective B3GALT6 causes EDSP2 and SEMDJL1	18	1.31e-06	5.63e-06	0.677	0.375	-0.564	5.92e-03	3.38e-05
Cap-dependent Translation Initiation	117	2.43e-37	1.32e-35	0.662	-0.423	0.509	2.56e-15	1.77e-21
Eukaryotic Translation Initiation	117	2.43e-37	1.32e-35	0.662	-0.423	0.509	2.56e-15	1.77e-21
SRP-dependent cotranslational protein targeting to membrane	110	3.90e-35	1.97e-33	0.662	-0.393	0.533	9.93e-13	4.19e-22
Reduction of cytosolic Ca++ levels	12	1.99e-04	5.13e-04	0.656	0.423	-0.502	1.12e-02	2.59e-03
Non-integrin membrane-ECM interactions	41	1.27e-16	2.25e-15	0.751	0.200	-0.724	2.68e-02	1.00e-15
MET activates PTK2 signaling	18	6.80e-08	3.72e-07	0.765	0.155	-0.749	2.56e-01	3.71e-08
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	5.49e-18	1.13e-16	0.646	-0.521	0.382	6.74e-12	4.78e-07
Mitochondrial iron-sulfur cluster biogenesis	13	1.73e-04	4.50e-04	0.635	-0.437	0.462	6.39e-03	3.96e-03
Translation initiation complex formation	57	4.76e-17	8.61e-16	0.634	-0.512	0.373	2.15e-11	1.12e-06
The activation of arylsulfatases	10	1.91e-03	3.91e-03	0.616	0.417	-0.454	2.25e-02	1.29e-02
HS-GAG degradation	19	7.84e-06	2.77e-05	0.612	0.424	-0.441	1.36e-03	8.62e-04
Ribosomal scanning and start codon recognition	57	4.22e-16	7.19e-15	0.615	-0.488	0.374	1.87e-10	1.03e-06
Major pathway of rRNA processing in the nucleolus and cytosol	180	4.38e-48	7.14e-46	0.607	-0.442	0.415	1.15e-24	6.33e-22
rRNA processing in the nucleus and cytosol	190	1.23e-50	2.57e-48	0.606	-0.452	0.404	4.72e-27	6.93e-22
Selenoamino acid metabolism	115	5.95e-32	2.64e-30	0.618	-0.336	0.519	4.63e-10	6.31e-22
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.07e-30	8.41e-29	0.606	-0.392	0.462	5.64e-13	1.93e-17
Nonsense-Mediated Decay (NMD)	113	2.07e-30	8.41e-29	0.606	-0.392	0.462	5.64e-13	1.93e-17
Complex I biogenesis	57	8.21e-22	2.23e-20	0.740	-0.123	0.729	1.09e-01	1.49e-21
Biotin transport and metabolism	11	8.11e-04	1.83e-03	0.631	0.561	-0.290	1.28e-03	9.61e-02
rRNA processing	214	9.34e-54	2.74e-51	0.589	-0.397	0.435	1.09e-23	4.38e-28
ATF4 activates genes in response to endoplasmic reticulum stress	26	4.79e-07	2.26e-06	0.583	-0.453	0.367	6.33e-05	1.20e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.38e-03	2.94e-03	0.607	-0.543	0.273	1.83e-03	1.18e-01
SLBP independent Processing of Histone Pre-mRNAs	10	3.65e-03	6.97e-03	0.586	-0.502	0.303	6.02e-03	9.69e-02
Regulation of expression of SLITs and ROBOs	166	3.50e-39	2.33e-37	0.570	-0.356	0.445	2.19e-15	4.05e-23
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	1.71e-03	3.56e-03	0.632	0.195	-0.602	2.86e-01	9.85e-04
A tetrasaccharide linker sequence is required for GAG synthesis	24	3.10e-06	1.21e-05	0.567	0.325	-0.465	5.89e-03	7.89e-05
Influenza Viral RNA Transcription and Replication	134	3.21e-30	1.27e-28	0.555	-0.386	0.398	1.09e-14	1.59e-15
Chondroitin sulfate biosynthesis	19	7.00e-05	1.98e-04	0.553	0.350	-0.428	8.18e-03	1.25e-03
PKA activation	16	2.75e-05	8.39e-05	0.646	0.145	-0.630	3.17e-01	1.29e-05
Diseases associated with glycosaminoglycan metabolism	35	2.97e-08	1.79e-07	0.551	0.273	-0.479	5.21e-03	9.35e-07
Respiratory electron transport	103	4.70e-27	1.64e-25	0.610	-0.160	0.589	4.90e-03	4.56e-25
Regulation of localization of FOXO transcription factors	12	1.54e-03	3.24e-03	0.580	0.206	-0.542	2.16e-01	1.15e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.KO	s.drug	p.KO	p.drug
Peptide chain elongation	87	2.79e-43	3.40e-41	0.8300	-4.22e-01	0.715000	9.35e-12	8.26e-31
Viral mRNA Translation	87	3.07e-43	3.46e-41	0.8300	-4.20e-01	0.715000	1.17e-11	7.10e-31
Formation of a pool of free 40S subunits	99	1.26e-44	1.68e-42	0.7890	-4.44e-01	0.652000	2.03e-14	3.21e-29
Eukaryotic Translation Termination	91	2.19e-41	1.89e-39	0.7940	-4.02e-01	0.684000	3.27e-11	1.32e-29
Eukaryotic Translation Elongation	92	1.82e-41	1.67e-39	0.7900	-4.12e-01	0.674000	8.16e-12	4.97e-29
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	1.43e-06	5.93e-06	0.7990	3.58e-01	-0.714000	2.55e-02	8.23e-06
Defective EXT2 causes exostoses 2	13	1.43e-06	5.93e-06	0.7990	3.58e-01	-0.714000	2.55e-02	8.23e-06
Laminin interactions	23	1.23e-11	1.39e-10	0.8270	2.69e-01	-0.782000	2.58e-02	8.23e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	6.60e-41	5.37e-39	0.7550	-4.23e-01	0.625000	3.36e-13	5.07e-27
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	6.86e-38	4.02e-36	0.7490	-4.24e-01	0.617000	1.55e-12	6.83e-25
Selenocysteine synthesis	91	1.38e-38	8.77e-37	0.7680	-3.55e-01	0.681000	4.60e-09	2.66e-29
Formation of the ternary complex, and subsequently, the 43S complex	50	7.28e-20	1.67e-18	0.7310	-5.01e-01	0.532000	8.83e-10	7.23e-11
Syndecan interactions	19	5.07e-10	4.45e-09	0.8440	2.16e-01	-0.816000	1.04e-01	7.21e-10
Mucopolysaccharidoses	11	1.36e-05	4.58e-05	0.7990	7.56e-01	-0.258000	1.41e-05	1.38e-01
Defective B4GALT7 causes EDS, progeroid type	18	1.10e-07	5.83e-07	0.7390	3.71e-01	-0.639000	6.44e-03	2.71e-06
L13a-mediated translational silencing of Ceruloplasmin expression	109	3.24e-39	2.26e-37	0.7020	-4.66e-01	0.525000	3.94e-17	2.32e-21
GTP hydrolysis and joining of the 60S ribosomal subunit	110	3.32e-38	2.03e-36	0.6900	-4.42e-01	0.530000	1.11e-15	6.60e-22
Defective B3GAT3 causes JDSSDHD	18	9.01e-07	3.96e-06	0.6870	3.76e-01	-0.575000	5.69e-03	2.43e-05
Other semaphorin interactions	15	8.68e-06	3.06e-05	0.6890	3.59e-01	-0.588000	1.59e-02	7.98e-05
Defective B3GALT6 causes EDSP2 and SEMDJL1	18	1.31e-06	5.63e-06	0.6770	3.75e-01	-0.564000	5.92e-03	3.38e-05
Cap-dependent Translation Initiation	117	2.43e-37	1.32e-35	0.6620	-4.23e-01	0.509000	2.56e-15	1.77e-21
Eukaryotic Translation Initiation	117	2.43e-37	1.32e-35	0.6620	-4.23e-01	0.509000	2.56e-15	1.77e-21
SRP-dependent cotranslational protein targeting to membrane	110	3.90e-35	1.97e-33	0.6620	-3.93e-01	0.533000	9.93e-13	4.19e-22
Reduction of cytosolic Ca++ levels	12	1.99e-04	5.13e-04	0.6560	4.23e-01	-0.502000	1.12e-02	2.59e-03
Non-integrin membrane-ECM interactions	41	1.27e-16	2.25e-15	0.7510	2.00e-01	-0.724000	2.68e-02	1.00e-15
MET activates PTK2 signaling	18	6.80e-08	3.72e-07	0.7650	1.55e-01	-0.749000	2.56e-01	3.71e-08
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	5.49e-18	1.13e-16	0.6460	-5.21e-01	0.382000	6.74e-12	4.78e-07
Mitochondrial iron-sulfur cluster biogenesis	13	1.73e-04	4.50e-04	0.6350	-4.37e-01	0.462000	6.39e-03	3.96e-03
Translation initiation complex formation	57	4.76e-17	8.61e-16	0.6340	-5.12e-01	0.373000	2.15e-11	1.12e-06
The activation of arylsulfatases	10	1.91e-03	3.91e-03	0.6160	4.17e-01	-0.454000	2.25e-02	1.29e-02
HS-GAG degradation	19	7.84e-06	2.77e-05	0.6120	4.24e-01	-0.441000	1.36e-03	8.62e-04
Ribosomal scanning and start codon recognition	57	4.22e-16	7.19e-15	0.6150	-4.88e-01	0.374000	1.87e-10	1.03e-06
Major pathway of rRNA processing in the nucleolus and cytosol	180	4.38e-48	7.14e-46	0.6070	-4.42e-01	0.415000	1.15e-24	6.33e-22
rRNA processing in the nucleus and cytosol	190	1.23e-50	2.57e-48	0.6060	-4.52e-01	0.404000	4.72e-27	6.93e-22
Selenoamino acid metabolism	115	5.95e-32	2.64e-30	0.6180	-3.36e-01	0.519000	4.63e-10	6.31e-22
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.07e-30	8.41e-29	0.6060	-3.92e-01	0.462000	5.64e-13	1.93e-17
Nonsense-Mediated Decay (NMD)	113	2.07e-30	8.41e-29	0.6060	-3.92e-01	0.462000	5.64e-13	1.93e-17
Complex I biogenesis	57	8.21e-22	2.23e-20	0.7400	-1.23e-01	0.729000	1.09e-01	1.49e-21
Biotin transport and metabolism	11	8.11e-04	1.83e-03	0.6310	5.61e-01	-0.290000	1.28e-03	9.61e-02
rRNA processing	214	9.34e-54	2.74e-51	0.5890	-3.97e-01	0.435000	1.09e-23	4.38e-28
ATF4 activates genes in response to endoplasmic reticulum stress	26	4.79e-07	2.26e-06	0.5830	-4.53e-01	0.367000	6.33e-05	1.20e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.38e-03	2.94e-03	0.6070	-5.43e-01	0.273000	1.83e-03	1.18e-01
SLBP independent Processing of Histone Pre-mRNAs	10	3.65e-03	6.97e-03	0.5860	-5.02e-01	0.303000	6.02e-03	9.69e-02
Regulation of expression of SLITs and ROBOs	166	3.50e-39	2.33e-37	0.5700	-3.56e-01	0.445000	2.19e-15	4.05e-23
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	1.71e-03	3.56e-03	0.6320	1.95e-01	-0.602000	2.86e-01	9.85e-04
A tetrasaccharide linker sequence is required for GAG synthesis	24	3.10e-06	1.21e-05	0.5670	3.25e-01	-0.465000	5.89e-03	7.89e-05
Influenza Viral RNA Transcription and Replication	134	3.21e-30	1.27e-28	0.5550	-3.86e-01	0.398000	1.09e-14	1.59e-15
Chondroitin sulfate biosynthesis	19	7.00e-05	1.98e-04	0.5530	3.50e-01	-0.428000	8.18e-03	1.25e-03
PKA activation	16	2.75e-05	8.39e-05	0.6460	1.45e-01	-0.630000	3.17e-01	1.29e-05
Diseases associated with glycosaminoglycan metabolism	35	2.97e-08	1.79e-07	0.5510	2.73e-01	-0.479000	5.21e-03	9.35e-07
Respiratory electron transport	103	4.70e-27	1.64e-25	0.6100	-1.60e-01	0.589000	4.90e-03	4.56e-25
Regulation of localization of FOXO transcription factors	12	1.54e-03	3.24e-03	0.5800	2.06e-01	-0.542000	2.16e-01	1.15e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	6.88e-11	7.09e-10	0.5340	-4.25e-01	0.323000	2.00e-07	7.81e-05
p53-Independent DNA Damage Response	50	6.88e-11	7.09e-10	0.5340	-4.25e-01	0.323000	2.00e-07	7.81e-05
p53-Independent G1/S DNA damage checkpoint	50	6.88e-11	7.09e-10	0.5340	-4.25e-01	0.323000	2.00e-07	7.81e-05
Vif-mediated degradation of APOBEC3G	52	2.64e-11	2.95e-10	0.5340	-4.31e-01	0.315000	7.39e-08	8.41e-05
CS/DS degradation	13	1.34e-03	2.84e-03	0.5610	5.11e-01	-0.233000	1.43e-03	1.46e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	3.75e-04	9.07e-04	0.5320	-4.47e-01	0.289000	1.42e-03	3.89e-02
Autodegradation of the E3 ubiquitin ligase COP1	49	2.15e-10	2.06e-09	0.5260	-4.25e-01	0.309000	2.54e-07	1.79e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	3.40e-10	3.15e-09	0.5270	-4.38e-01	0.293000	1.54e-07	4.48e-04
Cellular response to starvation	150	2.14e-29	8.05e-28	0.5180	-3.22e-01	0.406000	9.62e-12	9.26e-18
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	125	8.79e-33	4.03e-31	0.6150	-1.21e-01	0.603000	1.91e-02	2.15e-31
Apoptotic cleavage of cellular proteins	34	3.50e-08	2.05e-07	0.5620	1.90e-01	-0.529000	5.47e-02	9.48e-08
Stabilization of p53	53	9.56e-11	9.52e-10	0.5150	-4.25e-01	0.291000	8.54e-08	2.43e-04
APC/C:Cdc20 mediated degradation of Securin	66	8.36e-13	1.12e-11	0.5060	-3.68e-01	0.347000	2.36e-07	1.06e-06
MET promotes cell motility	29	1.04e-10	1.03e-09	0.7250	-1.10e-02	-0.725000	9.19e-01	1.37e-11
Mitochondrial translation elongation	90	3.60e-21	9.26e-20	0.5750	-1.63e-01	0.551000	7.65e-03	1.50e-19
Mitochondrial translation initiation	90	5.71e-21	1.42e-19	0.5720	-1.61e-01	0.549000	8.28e-03	2.15e-19
ROS sensing by NFE2L2	55	1.02e-11	1.18e-10	0.5340	-4.83e-01	0.226000	5.60e-10	3.69e-03
PKA-mediated phosphorylation of CREB	18	1.23e-05	4.18e-05	0.6380	6.90e-02	-0.634000	6.12e-01	3.14e-06
APC/C:Cdc20 mediated degradation of Cyclin B	24	2.14e-05	6.76e-05	0.5270	-2.16e-01	0.480000	6.68e-02	4.62e-05
HS-GAG biosynthesis	27	6.29e-07	2.89e-06	0.5800	1.32e-01	-0.565000	2.37e-01	3.75e-07
Response of EIF2AK1 (HRI) to heme deficiency	15	7.54e-04	1.70e-03	0.5480	-5.20e-01	0.174000	4.89e-04	2.43e-01
Autodegradation of Cdh1 by Cdh1:APC/C	64	9.86e-12	1.15e-10	0.4900	-3.54e-01	0.339000	9.46e-07	2.72e-06
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	4.45e-13	6.18e-12	0.4900	-3.66e-01	0.326000	8.04e-08	1.71e-06
Regulation of gene expression by Hypoxia-inducible Factor	10	4.08e-04	9.76e-04	0.7210	-2.91e-02	-0.720000	8.74e-01	7.95e-05
Mitochondrial translation termination	90	5.11e-20	1.21e-18	0.5590	-1.51e-01	0.538000	1.33e-02	1.05e-18
Platelet calcium homeostasis	24	3.77e-05	1.12e-04	0.5110	2.30e-01	-0.457000	5.10e-02	1.07e-04
mRNA decay by 3’ to 5’ exoribonuclease	16	2.01e-03	4.07e-03	0.4850	-3.11e-01	0.372000	3.11e-02	9.91e-03
PERK regulates gene expression	31	1.33e-06	5.64e-06	0.5210	-4.78e-01	0.205000	3.99e-06	4.82e-02
Vpu mediated degradation of CD4	50	2.77e-09	2.12e-08	0.4900	-4.07e-01	0.274000	6.34e-07	8.11e-04
Influenza Infection	153	7.01e-26	2.28e-24	0.4800	-3.57e-01	0.320000	2.24e-14	7.58e-12
Negative regulation of NOTCH4 signaling	54	1.04e-09	8.69e-09	0.4830	-3.83e-01	0.293000	1.09e-06	1.91e-04
SCF-beta-TrCP mediated degradation of Emi1	53	7.99e-10	6.84e-09	0.4920	-4.19e-01	0.257000	1.27e-07	1.20e-03
Heparan sulfate/heparin (HS-GAG) metabolism	48	8.73e-09	5.79e-08	0.4850	2.78e-01	-0.398000	8.49e-04	1.84e-06
RHOF GTPase cycle	41	1.50e-10	1.46e-09	0.5970	8.37e-02	-0.591000	3.54e-01	5.78e-11
Formation of ATP by chemiosmotic coupling	18	1.94e-05	6.18e-05	0.6270	-4.48e-02	0.626000	7.42e-01	4.27e-06
Regulation of Apoptosis	51	2.62e-09	2.02e-08	0.4870	-4.15e-01	0.255000	2.98e-07	1.60e-03
Interleukin-15 signaling	14	3.64e-04	8.89e-04	0.6060	6.72e-02	-0.602000	6.64e-01	9.64e-05
rRNA modification in the nucleus and cytosol	60	2.08e-12	2.52e-11	0.5310	-5.05e-01	0.163000	1.24e-11	2.94e-02
RHOJ GTPase cycle	54	6.18e-13	8.46e-12	0.5780	9.79e-02	-0.570000	2.13e-01	4.18e-13
The role of GTSE1 in G2/M progression after G2 checkpoint	58	3.30e-10	3.08e-09	0.4790	-3.92e-01	0.275000	2.38e-07	2.85e-04
Mitochondrial translation	96	6.75e-20	1.57e-18	0.5390	-1.48e-01	0.518000	1.21e-02	1.55e-18
APC/C:Cdc20 mediated degradation of mitotic proteins	74	1.65e-12	2.07e-11	0.4720	-3.51e-01	0.315000	1.72e-07	2.76e-06
VLDLR internalisation and degradation	11	1.39e-02	2.39e-02	0.4880	2.40e-01	-0.425000	1.68e-01	1.46e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	1.46e-12	1.89e-11	0.4700	-3.59e-01	0.303000	7.46e-08	5.60e-06
CDT1 association with the CDC6:ORC:origin complex	57	1.21e-09	9.92e-09	0.4680	-3.38e-01	0.323000	1.01e-05	2.43e-05
Degradation of DVL	55	7.35e-10	6.33e-09	0.4850	-4.25e-01	0.234000	5.01e-08	2.70e-03
FOXO-mediated transcription of cell cycle genes	15	1.84e-05	5.97e-05	0.6970	-3.90e-02	-0.696000	7.94e-01	3.06e-06
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	11	1.31e-02	2.27e-02	0.4940	2.06e-01	-0.449000	2.37e-01	9.90e-03
Chondroitin sulfate/dermatan sulfate metabolism	48	4.57e-08	2.58e-07	0.4630	2.95e-01	-0.356000	4.08e-04	1.93e-05
Hh mutants are degraded by ERAD	54	3.17e-09	2.38e-08	0.4710	-4.04e-01	0.243000	2.79e-07	2.03e-03
Cohesin Loading onto Chromatin	10	1.94e-05	6.18e-05	0.8650	-1.96e-01	-0.842000	2.83e-01	3.98e-06
STAT3 nuclear events downstream of ALK signaling	10	9.72e-03	1.73e-02	0.5430	1.14e-01	-0.531000	5.32e-01	3.61e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	7.57e-09	5.11e-08	0.4640	-3.83e-01	0.261000	1.37e-06	9.89e-04
Regulation of RUNX3 expression and activity	54	7.29e-10	6.32e-09	0.4930	-4.58e-01	0.183000	5.93e-09	2.02e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	2.45e-02	3.97e-02	0.4520	3.47e-01	-0.290000	4.64e-02	9.53e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	3.21e-11	3.49e-10	0.4520	-3.41e-01	0.296000	5.74e-07	1.36e-05
Ubiquitin-dependent degradation of Cyclin D	50	4.03e-08	2.32e-07	0.4550	-3.66e-01	0.271000	7.51e-06	9.15e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.24e-08	8.05e-08	0.4580	-3.78e-01	0.259000	1.94e-06	1.12e-03
mRNA Splicing - Minor Pathway	52	3.23e-08	1.91e-07	0.4490	-3.11e-01	0.323000	1.03e-04	5.51e-05
Cross-presentation of soluble exogenous antigens (endosomes)	45	2.31e-07	1.18e-06	0.4550	-3.78e-01	0.253000	1.12e-05	3.28e-03
rRNA processing in the mitochondrion	24	8.25e-08	4.43e-07	0.6740	4.17e-02	0.673000	7.24e-01	1.14e-08
Regulation of ornithine decarboxylase (ODC)	49	4.03e-08	2.32e-07	0.4620	-4.01e-01	0.230000	1.22e-06	5.39e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	7.49e-11	7.52e-10	0.4470	-3.37e-01	0.293000	8.99e-07	1.93e-05
RND1 GTPase cycle	42	1.49e-08	9.52e-08	0.5220	1.22e-01	-0.508000	1.72e-01	1.22e-08
Translation	293	3.38e-40	2.60e-38	0.4350	-2.89e-01	0.326000	1.51e-17	7.64e-22
DCC mediated attractive signaling	14	4.56e-05	1.34e-04	0.6940	-7.57e-02	-0.690000	6.24e-01	7.81e-06
Adherens junctions interactions	29	1.22e-04	3.25e-04	0.4340	2.81e-01	-0.331000	8.81e-03	2.02e-03
NIK–>noncanonical NF-kB signaling	57	5.45e-09	3.82e-08	0.4530	-4.02e-01	0.211000	1.55e-07	5.94e-03
Degradation of AXIN	53	2.88e-08	1.75e-07	0.4490	-3.98e-01	0.209000	5.45e-07	8.50e-03
CDK-mediated phosphorylation and removal of Cdc6	71	4.49e-10	4.04e-09	0.4290	-3.11e-01	0.295000	5.75e-06	1.67e-05
ALK mutants bind TKIs	12	5.44e-04	1.27e-03	0.6470	-4.16e-02	-0.646000	8.03e-01	1.06e-04
RND3 GTPase cycle	41	1.42e-07	7.41e-07	0.4930	1.27e-01	-0.477000	1.59e-01	1.26e-07
Signaling by Hippo	20	1.90e-08	1.19e-07	0.7810	-1.62e-01	-0.764000	2.09e-01	3.23e-09
Membrane binding and targetting of GAG proteins	14	2.14e-04	5.50e-04	0.6350	-6.34e-01	-0.032300	4.00e-05	8.34e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	2.14e-04	5.50e-04	0.6350	-6.34e-01	-0.032300	4.00e-05	8.34e-01
Signaling by FLT3 fusion proteins	19	4.96e-06	1.85e-05	0.6570	-5.33e-02	-0.655000	6.88e-01	7.73e-07
Caspase-mediated cleavage of cytoskeletal proteins	12	1.13e-02	2.00e-02	0.4850	1.35e-01	-0.466000	4.20e-01	5.17e-03
p53-Dependent G1 DNA Damage Response	62	4.70e-09	3.36e-08	0.4350	-3.68e-01	0.232000	5.27e-07	1.60e-03
p53-Dependent G1/S DNA damage checkpoint	62	4.70e-09	3.36e-08	0.4350	-3.68e-01	0.232000	5.27e-07	1.60e-03
Dectin-1 mediated noncanonical NF-kB signaling	59	4.29e-09	3.13e-08	0.4490	-4.05e-01	0.194000	7.27e-08	9.81e-03
RHOQ GTPase cycle	58	1.84e-12	2.27e-11	0.5520	4.17e-02	-0.550000	5.83e-01	4.17e-13
Hyaluronan metabolism	14	5.33e-03	9.99e-03	0.4870	4.73e-01	-0.117000	2.18e-03	4.50e-01
PKA activation in glucagon signalling	15	2.33e-03	4.65e-03	0.5090	8.80e-02	-0.501000	5.55e-01	7.70e-04
RHOB GTPase cycle	69	2.01e-12	2.46e-11	0.5000	9.99e-02	-0.490000	1.51e-01	1.98e-12
RHOU GTPase cycle	40	4.02e-10	3.66e-09	0.5990	-1.03e-02	-0.599000	9.10e-01	5.39e-11
Glycosaminoglycan metabolism	109	1.72e-15	2.86e-14	0.4390	1.92e-01	-0.395000	5.45e-04	9.56e-13
RNA Polymerase I Promoter Opening	24	9.80e-04	2.16e-03	0.4190	-2.44e-01	0.341000	3.87e-02	3.81e-03
Defective CFTR causes cystic fibrosis	58	7.11e-09	4.89e-08	0.4490	-4.16e-01	0.169000	4.27e-08	2.61e-02
G1/S DNA Damage Checkpoints	64	8.32e-09	5.54e-08	0.4220	-3.55e-01	0.228000	9.19e-07	1.59e-03
Regulation of commissural axon pathfinding by SLIT and ROBO	10	1.14e-02	2.01e-02	0.5400	4.05e-02	-0.539000	8.25e-01	3.18e-03
tRNA processing in the mitochondrion	20	6.21e-08	3.42e-07	0.7550	1.60e-01	0.738000	2.16e-01	1.09e-08
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	1.04e-05	3.59e-05	0.5150	6.77e-02	-0.510000	5.35e-01	2.96e-06
Adenylate cyclase inhibitory pathway	12	3.49e-04	8.58e-04	0.6700	-8.82e-02	-0.664000	5.97e-01	6.71e-05
Hh mutants abrogate ligand secretion	57	7.78e-08	4.20e-07	0.4200	-3.60e-01	0.215000	2.54e-06	4.93e-03
Metabolism of polyamines	57	3.42e-08	2.01e-07	0.4320	-3.92e-01	0.182000	3.00e-07	1.78e-02
Assembly Of The HIV Virion	16	1.68e-04	4.39e-04	0.6020	-6.01e-01	-0.028600	3.10e-05	8.43e-01
APC-Cdc20 mediated degradation of Nek2A	26	6.87e-04	1.57e-03	0.4140	-2.25e-01	0.347000	4.73e-02	2.17e-03
Degradation of GLI1 by the proteasome	57	7.94e-08	4.28e-07	0.4200	-3.68e-01	0.203000	1.55e-06	8.13e-03
Molecules associated with elastic fibres	25	1.02e-04	2.75e-04	0.4850	9.30e-02	-0.476000	4.21e-01	3.77e-05
Insulin processing	25	6.46e-06	2.34e-05	0.5620	2.24e-03	-0.562000	9.85e-01	1.14e-06
Elastic fibre formation	35	4.03e-06	1.52e-05	0.4760	9.77e-02	-0.466000	3.17e-01	1.83e-06
VEGFR2 mediated cell proliferation	19	2.74e-05	8.38e-05	0.6090	-4.60e-02	-0.607000	7.28e-01	4.58e-06
Integrin cell surface interactions	57	2.12e-07	1.09e-06	0.4060	2.19e-01	-0.342000	4.17e-03	8.06e-06
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.15e-03	2.50e-03	0.6450	-8.01e-02	-0.640000	6.45e-01	2.36e-04
Regulation of APC/C activators between G1/S and early anaphase	79	8.70e-10	7.36e-09	0.4010	-3.28e-01	0.232000	4.73e-07	3.63e-04
APC/C-mediated degradation of cell cycle proteins	86	2.19e-10	2.07e-09	0.3970	-3.16e-01	0.240000	4.01e-07	1.17e-04
Regulation of mitotic cell cycle	86	2.19e-10	2.07e-09	0.3970	-3.16e-01	0.240000	4.01e-07	1.17e-04
Constitutive Signaling by Overexpressed ERBB2	11	1.41e-02	2.42e-02	0.5010	5.76e-02	-0.498000	7.41e-01	4.25e-03
CDC42 GTPase cycle	153	1.05e-22	3.02e-21	0.4590	1.07e-01	-0.447000	2.26e-02	1.32e-21
Phosphorylation of the APC/C	20	4.28e-03	8.12e-03	0.4100	-1.84e-01	0.367000	1.55e-01	4.52e-03
FGFR2 alternative splicing	25	7.43e-04	1.68e-03	0.4240	-3.94e-01	0.155000	6.46e-04	1.78e-01
Gap junction trafficking and regulation	20	2.45e-03	4.87e-03	0.4340	1.37e-01	-0.412000	2.89e-01	1.42e-03
Miscellaneous transport and binding events	23	3.63e-06	1.39e-05	0.6050	-5.55e-02	-0.603000	6.45e-01	5.57e-07
Regulation of HMOX1 expression and activity	63	7.66e-09	5.15e-08	0.4320	-4.10e-01	0.136000	1.83e-08	6.23e-02
The citric acid (TCA) cycle and respiratory electron transport	173	1.18e-21	3.14e-20	0.4180	-1.52e-01	0.389000	5.42e-04	1.04e-18
RHOD GTPase cycle	52	4.60e-09	3.32e-08	0.4890	5.43e-02	-0.486000	4.98e-01	1.27e-09
RHOH GTPase cycle	35	5.00e-08	2.80e-07	0.5660	-2.49e-02	-0.565000	7.99e-01	6.96e-09
RNA Polymerase II Transcription Termination	65	1.41e-07	7.36e-07	0.3840	-2.99e-01	0.241000	3.01e-05	7.73e-04
Trafficking of GluR2-containing AMPA receptors	16	2.01e-02	3.32e-02	0.3850	3.06e-01	-0.234000	3.39e-02	1.06e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	4.02e-04	9.66e-04	0.4670	-4.61e-01	0.077700	1.30e-04	5.19e-01
Formation of the Early Elongation Complex	33	3.73e-05	1.12e-04	0.4430	-4.30e-01	0.106000	1.91e-05	2.90e-01
Formation of the HIV-1 Early Elongation Complex	33	3.73e-05	1.12e-04	0.4430	-4.30e-01	0.106000	1.91e-05	2.90e-01
CLEC7A (Dectin-1) induces NFAT activation	11	3.38e-06	1.31e-05	0.8970	-3.08e-01	-0.842000	7.70e-02	1.30e-06
Interleukin-7 signaling	23	7.17e-04	1.63e-03	0.4480	9.62e-02	-0.437000	4.24e-01	2.81e-04
RHOC GTPase cycle	72	2.08e-14	3.27e-13	0.5390	-5.20e-03	-0.539000	9.39e-01	2.54e-15
Degradation of GLI2 by the proteasome	57	1.10e-06	4.75e-06	0.3840	-3.25e-01	0.205000	2.23e-05	7.47e-03
Regulated proteolysis of p75NTR	11	1.82e-02	3.03e-02	0.4870	4.49e-02	-0.484000	7.96e-01	5.39e-03
Regulation of RUNX2 expression and activity	70	7.42e-09	5.04e-08	0.4090	-3.82e-01	0.145000	3.16e-08	3.60e-02
Mitochondrial protein import	64	2.31e-07	1.18e-06	0.3820	-2.03e-01	0.324000	4.91e-03	7.42e-06
VEGFR2 mediated vascular permeability	27	8.57e-05	2.36e-04	0.4740	5.46e-02	-0.471000	6.23e-01	2.27e-05
Gap junction trafficking	18	9.94e-03	1.77e-02	0.3990	1.57e-01	-0.367000	2.50e-01	7.07e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression	12	7.09e-04	1.62e-03	0.6420	-1.11e-01	-0.633000	5.04e-01	1.48e-04
Cell-cell junction organization	50	1.13e-05	3.85e-05	0.3730	2.15e-01	-0.305000	8.64e-03	1.92e-04
Glycosphingolipid metabolism	42	6.19e-05	1.77e-04	0.3760	3.18e-01	-0.201000	3.67e-04	2.45e-02
RHOA GTPase cycle	146	3.70e-20	8.89e-19	0.4440	8.18e-02	-0.436000	8.77e-02	8.34e-20
Cristae formation	31	2.43e-05	7.57e-05	0.4720	-4.86e-02	0.469000	6.39e-01	6.06e-06
ECM proteoglycans	43	4.73e-06	1.77e-05	0.4250	1.06e-01	-0.412000	2.28e-01	2.97e-06
LDL clearance	16	2.30e-02	3.74e-02	0.3810	1.86e-01	-0.332000	1.99e-01	2.14e-02
HIV elongation arrest and recovery	32	5.19e-06	1.91e-05	0.5000	-5.00e-01	0.016000	9.78e-07	8.75e-01
Pausing and recovery of HIV elongation	32	5.19e-06	1.91e-05	0.5000	-5.00e-01	0.016000	9.78e-07	8.75e-01
Pausing and recovery of Tat-mediated HIV elongation	30	1.76e-05	5.73e-05	0.4890	-4.88e-01	0.027600	3.67e-06	7.93e-01
Tat-mediated HIV elongation arrest and recovery	30	1.76e-05	5.73e-05	0.4890	-4.88e-01	0.027600	3.67e-06	7.93e-01
Assembly of the pre-replicative complex	90	1.93e-09	1.50e-08	0.3690	-2.19e-01	0.297000	3.38e-04	1.10e-06
Role of LAT2/NTAL/LAB on calcium mobilization	13	5.82e-04	1.35e-03	0.6250	-1.01e-01	-0.616000	5.27e-01	1.18e-04
Receptor Mediated Mitophagy	11	2.63e-05	8.10e-05	0.8190	-7.76e-01	-0.263000	8.30e-06	1.31e-01
Signaling by ROBO receptors	210	1.76e-20	4.30e-19	0.3640	-2.91e-01	0.219000	3.63e-13	4.27e-08
Asymmetric localization of PCP proteins	62	1.30e-07	6.85e-07	0.4010	-3.79e-01	0.129000	2.34e-07	8.00e-02
RAC1 GTPase cycle	176	5.03e-26	1.67e-24	0.4650	4.44e-02	-0.463000	3.09e-01	2.75e-26
S33 mutants of beta-catenin aren’t phosphorylated	15	7.71e-07	3.45e-06	0.8110	-2.60e-01	-0.768000	8.08e-02	2.62e-07
S37 mutants of beta-catenin aren’t phosphorylated	15	7.71e-07	3.45e-06	0.8110	-2.60e-01	-0.768000	8.08e-02	2.62e-07
S45 mutants of beta-catenin aren’t phosphorylated	15	7.71e-07	3.45e-06	0.8110	-2.60e-01	-0.768000	8.08e-02	2.62e-07
Signaling by CTNNB1 phospho-site mutants	15	7.71e-07	3.45e-06	0.8110	-2.60e-01	-0.768000	8.08e-02	2.62e-07
Signaling by GSK3beta mutants	15	7.71e-07	3.45e-06	0.8110	-2.60e-01	-0.768000	8.08e-02	2.62e-07
T41 mutants of beta-catenin aren’t phosphorylated	15	7.71e-07	3.45e-06	0.8110	-2.60e-01	-0.768000	8.08e-02	2.62e-07
RNA Pol II CTD phosphorylation and interaction with CE	27	9.01e-04	2.01e-03	0.4040	-3.85e-01	0.122000	5.28e-04	2.74e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	9.01e-04	2.01e-03	0.4040	-3.85e-01	0.122000	5.28e-04	2.74e-01
Amine ligand-binding receptors	22	9.60e-03	1.72e-02	0.3580	2.36e-01	-0.269000	5.54e-02	2.88e-02
GLI3 is processed to GLI3R by the proteasome	57	3.47e-06	1.34e-05	0.3680	-3.21e-01	0.180000	2.76e-05	1.85e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	3.92e-07	1.88e-06	0.3780	-3.44e-01	0.156000	1.91e-06	3.05e-02
Signaling by PDGFR in disease	19	5.53e-07	2.59e-06	0.7260	-1.98e-01	-0.698000	1.35e-01	1.36e-07
Formation of HIV elongation complex in the absence of HIV Tat	44	2.67e-07	1.32e-06	0.4750	-4.74e-01	0.025900	5.22e-08	7.66e-01
CaM pathway	31	1.91e-05	6.12e-05	0.4800	2.04e-02	-0.479000	8.44e-01	3.83e-06
Calmodulin induced events	31	1.91e-05	6.12e-05	0.4800	2.04e-02	-0.479000	8.44e-01	3.83e-06
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	8.74e-07	3.86e-06	0.4660	-4.64e-01	0.034700	1.89e-07	6.97e-01
HIV Transcription Elongation	42	8.74e-07	3.86e-06	0.4660	-4.64e-01	0.034700	1.89e-07	6.97e-01
Tat-mediated elongation of the HIV-1 transcript	42	8.74e-07	3.86e-06	0.4660	-4.64e-01	0.034700	1.89e-07	6.97e-01
mRNA Splicing - Major Pathway	179	1.87e-17	3.51e-16	0.3640	-3.13e-01	0.187000	5.22e-13	1.66e-05
MECP2 regulates neuronal receptors and channels	17	2.74e-04	6.95e-04	0.5710	-6.83e-02	-0.567000	6.26e-01	5.16e-05
Growth hormone receptor signaling	20	1.39e-04	3.70e-04	0.5460	-4.84e-02	-0.544000	7.08e-01	2.51e-05
mRNA Splicing	187	1.09e-17	2.18e-16	0.3580	-2.99e-01	0.196000	1.57e-12	3.59e-06
RND2 GTPase cycle	41	1.41e-05	4.71e-05	0.4170	8.75e-02	-0.408000	3.32e-01	6.24e-06
DAG and IP3 signaling	37	6.07e-07	2.81e-06	0.5070	-1.19e-02	-0.507000	9.00e-01	9.38e-08
RUNX1 regulates transcription of genes involved in differentiation of HSCs	87	1.47e-08	9.48e-08	0.3560	-2.95e-01	0.199000	1.96e-06	1.31e-03
Signaling by FGFR3 fusions in cancer	10	1.28e-03	2.75e-03	0.6780	-1.64e-01	-0.658000	3.69e-01	3.13e-04
Josephin domain DUBs	10	2.90e-02	4.61e-02	0.4830	-4.83e-01	0.011300	8.21e-03	9.50e-01
Orc1 removal from chromatin	69	9.86e-07	4.31e-06	0.3490	-2.36e-01	0.257000	7.00e-04	2.21e-04
Apoptotic execution phase	47	1.06e-05	3.62e-05	0.3910	1.20e-01	-0.373000	1.53e-01	9.87e-06
Switching of origins to a post-replicative state	89	1.60e-08	1.01e-07	0.3510	-2.17e-01	0.276000	4.11e-04	6.93e-06
Recycling pathway of L1	27	8.83e-06	3.10e-05	0.5380	-4.56e-02	-0.536000	6.81e-01	1.41e-06
Keratan sulfate/keratin metabolism	29	2.02e-04	5.20e-04	0.4350	5.93e-02	-0.431000	5.80e-01	5.81e-05
Activation of NF-kappaB in B cells	65	1.21e-07	6.41e-07	0.3930	-3.76e-01	0.114000	1.56e-07	1.11e-01
DNA methylation	26	3.21e-03	6.24e-03	0.3700	-1.54e-01	0.336000	1.73e-01	3.02e-03
DARPP-32 events	23	1.52e-03	3.19e-03	0.4260	6.90e-02	-0.420000	5.67e-01	4.83e-04
SCF(Skp2)-mediated degradation of p27/p21	60	6.61e-06	2.37e-05	0.3480	-2.73e-01	0.215000	2.51e-04	3.92e-03
Signaling by Leptin	10	7.15e-03	1.31e-02	0.5790	-8.57e-02	-0.573000	6.39e-01	1.70e-03
Signaling by FGFR2 IIIa TM	19	1.36e-02	2.35e-02	0.3750	-3.50e-01	0.137000	8.35e-03	3.01e-01
RAC2 GTPase cycle	85	1.86e-17	3.51e-16	0.5540	-6.36e-02	-0.550000	3.10e-01	1.71e-18
Condensation of Prophase Chromosomes	34	1.32e-03	2.82e-03	0.3440	-2.51e-01	0.235000	1.14e-02	1.75e-02
Myogenesis	25	6.74e-04	1.55e-03	0.4350	5.42e-02	-0.431000	6.39e-01	1.88e-04
Metabolism of RNA	677	2.53e-61	1.24e-58	0.3600	-3.20e-01	0.166000	5.42e-46	1.74e-13
Mitophagy	28	6.80e-06	2.42e-05	0.5350	-5.32e-01	-0.047600	1.07e-06	6.63e-01
UCH proteinases	90	4.12e-09	3.02e-08	0.3650	-3.31e-01	0.153000	5.58e-08	1.22e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.77e-02	2.95e-02	0.3510	-1.83e-01	0.300000	1.57e-01	2.02e-02
Hyaluronan uptake and degradation	10	2.27e-02	3.70e-02	0.5020	5.02e-01	0.022200	5.98e-03	9.03e-01
RHOG GTPase cycle	74	1.84e-13	2.59e-12	0.5160	-3.51e-02	-0.514000	6.02e-01	1.91e-14
mRNA Capping	29	5.04e-04	1.19e-03	0.4100	-4.03e-01	0.075500	1.75e-04	4.82e-01
SUMOylation of intracellular receptors	27	1.92e-03	3.94e-03	0.3820	1.08e-01	-0.367000	3.33e-01	9.71e-04
Cell junction organization	75	4.87e-09	3.46e-08	0.4040	7.64e-02	-0.397000	2.53e-01	2.67e-09
RHOV GTPase cycle	37	8.06e-10	6.87e-09	0.6240	-1.36e-01	-0.609000	1.51e-01	1.41e-10
PINK1-PRKN Mediated Mitophagy	21	2.10e-03	4.26e-03	0.4370	-4.36e-01	0.036100	5.43e-04	7.75e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.28e-02	2.24e-02	0.4050	-3.99e-01	0.072800	4.42e-03	6.03e-01
Ca-dependent events	33	3.31e-06	1.29e-05	0.5060	-3.51e-02	-0.505000	7.27e-01	5.11e-07
mRNA 3’-end processing	56	3.39e-05	1.02e-04	0.3340	-2.63e-01	0.206000	6.60e-04	7.51e-03
Interleukin receptor SHC signaling	21	1.42e-03	3.00e-03	0.4530	1.52e-02	-0.453000	9.04e-01	3.26e-04
PECAM1 interactions	11	1.71e-02	2.88e-02	0.4970	-2.91e-02	-0.496000	8.67e-01	4.35e-03
Formation of TC-NER Pre-Incision Complex	53	5.23e-06	1.91e-05	0.3810	-3.69e-01	0.096700	3.36e-06	2.23e-01
RORA activates gene expression	18	9.75e-06	3.38e-05	0.6670	-1.79e-01	-0.643000	1.89e-01	2.34e-06
NOTCH4 Intracellular Domain Regulates Transcription	19	1.93e-02	3.19e-02	0.3600	1.25e-01	-0.338000	3.47e-01	1.07e-02
Signaling by cytosolic FGFR1 fusion mutants	18	7.09e-04	1.62e-03	0.5210	-5.62e-02	-0.518000	6.80e-01	1.40e-04
Signaling by MET	66	7.37e-11	7.45e-10	0.4860	-2.43e-02	-0.485000	7.32e-01	8.78e-12
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.26e-02	3.69e-02	0.3760	-3.63e-01	0.096500	9.54e-03	4.91e-01
RAC3 GTPase cycle	89	4.30e-18	9.00e-17	0.5540	-8.72e-02	-0.547000	1.55e-01	4.58e-19
Defective B3GALTL causes PpS	36	1.22e-03	2.63e-03	0.3390	3.00e-01	-0.158000	1.86e-03	1.01e-01
Processing of Capped Intron-Containing Pre-mRNA	238	1.80e-21	4.70e-20	0.3550	-3.32e-01	0.125000	9.00e-19	8.85e-04
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	37	9.88e-04	2.17e-03	0.3400	-3.03e-01	0.153000	1.42e-03	1.06e-01
Extracellular matrix organization	249	5.50e-22	1.52e-20	0.3510	1.28e-01	-0.327000	4.90e-04	5.56e-19
Deactivation of the beta-catenin transactivating complex	41	3.69e-04	8.98e-04	0.3460	1.37e-01	-0.318000	1.30e-01	4.28e-04
Synthesis of very long-chain fatty acyl-CoAs	22	1.39e-02	2.39e-02	0.3480	1.33e-01	-0.321000	2.81e-01	9.08e-03
Signaling by PDGFRA extracellular domain mutants	12	4.81e-05	1.41e-04	0.7630	-2.63e-01	-0.716000	1.14e-01	1.74e-05
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	4.81e-05	1.41e-04	0.7630	-2.63e-01	-0.716000	1.14e-01	1.74e-05
Inhibition of DNA recombination at telomere	39	9.43e-04	2.09e-03	0.3310	-2.88e-01	0.164000	1.87e-03	7.67e-02
RNA Polymerase I Promoter Escape	52	1.64e-04	4.31e-04	0.3190	-2.23e-01	0.228000	5.39e-03	4.45e-03
Prolonged ERK activation events	14	3.85e-04	9.29e-04	0.6230	-1.54e-01	-0.604000	3.17e-01	9.13e-05
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	34	3.81e-04	9.21e-04	0.3850	-3.79e-01	0.070700	1.32e-04	4.75e-01
PRC2 methylates histones and DNA	34	3.48e-03	6.69e-03	0.3180	-2.11e-01	0.237000	3.28e-02	1.66e-02
L1CAM interactions	92	3.02e-14	4.66e-13	0.4760	-2.88e-02	-0.475000	6.33e-01	3.10e-15
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.72e-02	4.36e-02	0.3240	-1.71e-01	0.275000	1.74e-01	2.92e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.72e-02	4.36e-02	0.3240	-1.71e-01	0.275000	1.74e-01	2.92e-02
O-linked glycosylation of mucins	48	1.94e-04	5.03e-04	0.3310	1.51e-01	-0.295000	7.06e-02	4.04e-04
Regulation of mRNA stability by proteins that bind AU-rich elements	87	3.13e-08	1.86e-07	0.3540	-3.36e-01	0.109000	5.79e-08	7.86e-02
G-protein mediated events	48	5.57e-09	3.89e-08	0.5180	-6.95e-02	-0.514000	4.05e-01	7.30e-10
Regulation of beta-cell development	29	7.66e-03	1.40e-02	0.3200	1.74e-01	-0.269000	1.05e-01	1.22e-02
DNA Replication Pre-Initiation	107	7.36e-09	5.04e-08	0.3290	-1.45e-01	0.295000	9.36e-03	1.29e-07
Establishment of Sister Chromatid Cohesion	11	5.26e-05	1.53e-04	0.7950	-2.98e-01	-0.737000	8.65e-02	2.30e-05
Beta-catenin phosphorylation cascade	17	8.19e-07	3.66e-06	0.7620	-2.73e-01	-0.711000	5.12e-02	3.79e-07
PLC beta mediated events	44	5.86e-08	3.27e-07	0.5060	-6.47e-02	-0.502000	4.57e-01	8.07e-09
VEGFA-VEGFR2 Pathway	91	4.15e-16	7.15e-15	0.5140	-7.20e-02	-0.509000	2.35e-01	4.25e-17
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	4.90e-10	4.35e-09	0.5410	-9.61e-02	-0.533000	2.39e-01	6.95e-11
Hedgehog ligand biogenesis	63	3.20e-05	9.70e-05	0.3170	-2.70e-01	0.166000	2.05e-04	2.27e-02
O-glycosylation of TSR domain-containing proteins	37	2.31e-03	4.62e-03	0.3170	2.69e-01	-0.167000	4.57e-03	7.90e-02
Cargo concentration in the ER	31	1.74e-05	5.71e-05	0.4880	-5.14e-02	-0.486000	6.20e-01	2.85e-06
FCGR3A-mediated IL10 synthesis	32	4.09e-06	1.54e-05	0.5130	-7.50e-02	-0.508000	4.63e-01	6.58e-07
NoRC negatively regulates rRNA expression	67	2.83e-05	8.62e-05	0.3090	-2.45e-01	0.188000	5.24e-04	7.90e-03
TNFR2 non-canonical NF-kB pathway	89	5.23e-07	2.46e-06	0.3160	-2.73e-01	0.159000	8.36e-06	9.54e-03
Signaling by ERBB2 ECD mutants	16	1.28e-02	2.24e-02	0.4240	8.55e-03	-0.423000	9.53e-01	3.36e-03
ER-Phagosome pathway	86	3.29e-07	1.60e-06	0.3290	-3.02e-01	0.130000	1.32e-06	3.66e-02
O-linked glycosylation	95	3.52e-07	1.70e-06	0.3090	1.82e-01	-0.250000	2.16e-03	2.59e-05
FCERI mediated NF-kB activation	75	4.56e-08	2.58e-07	0.3820	-3.79e-01	0.050100	1.40e-08	4.53e-01
Hedgehog ‘on’ state	84	2.42e-07	1.22e-06	0.3370	-3.19e-01	0.109000	4.14e-07	8.40e-02
Netrin-1 signaling	45	1.13e-09	9.39e-09	0.5610	-1.21e-01	-0.548000	1.59e-01	1.96e-10
Negative epigenetic regulation of rRNA expression	70	1.97e-05	6.25e-05	0.3080	-2.59e-01	0.166000	1.79e-04	1.60e-02
Signaling by PDGF	51	3.43e-08	2.01e-07	0.4770	-4.95e-02	-0.474000	5.40e-01	4.55e-09
RAF-independent MAPK1/3 activation	22	1.85e-05	5.97e-05	0.5850	-1.43e-01	-0.567000	2.44e-01	4.05e-06
Signaling by VEGF	99	1.95e-17	3.61e-16	0.5150	-8.45e-02	-0.508000	1.46e-01	2.18e-18
Interaction between L1 and Ankyrins	25	2.47e-02	3.99e-02	0.3000	2.22e-01	-0.201000	5.45e-02	8.16e-02
Cell-Cell communication	105	2.33e-14	3.63e-13	0.4480	-2.52e-02	-0.447000	6.55e-01	2.40e-15
RNA Polymerase I Promoter Clearance	71	1.56e-05	5.17e-05	0.3100	-2.71e-01	0.150000	7.83e-05	2.90e-02
RNA Polymerase I Transcription	71	1.56e-05	5.17e-05	0.3100	-2.71e-01	0.150000	7.83e-05	2.90e-02
Packaging Of Telomere Ends	24	1.53e-02	2.61e-02	0.3300	-3.13e-01	0.107000	8.03e-03	3.63e-01
SIRT1 negatively regulates rRNA expression	29	1.49e-02	2.56e-02	0.2970	-1.88e-01	0.229000	7.91e-02	3.25e-02
ERKs are inactivated	13	4.26e-06	1.60e-05	0.8210	-3.33e-01	-0.751000	3.74e-02	2.76e-06
Synthesis of PIPs at the early endosome membrane	16	1.36e-06	5.69e-06	0.7730	-2.98e-01	-0.713000	3.91e-02	7.87e-07
RHO GTPase cycle	433	1.74e-48	3.19e-46	0.4130	-5.48e-05	-0.413000	9.98e-01	2.34e-49
Diseases of glycosylation	129	1.55e-08	9.85e-08	0.2910	1.99e-01	-0.213000	9.74e-05	2.89e-05
Regulation of RAS by GAPs	64	9.56e-06	3.32e-05	0.3390	-3.29e-01	0.082000	5.40e-06	2.56e-01
DNA Damage Recognition in GG-NER	38	2.66e-03	5.26e-03	0.3110	-2.86e-01	0.123000	2.30e-03	1.88e-01
G alpha (z) signalling events	39	8.99e-05	2.46e-04	0.3970	1.24e-02	-0.396000	8.93e-01	1.83e-05
Transport of bile salts and organic acids, metal ions and amine compounds	58	2.16e-05	6.79e-05	0.3440	7.21e-02	-0.336000	3.42e-01	9.37e-06
CRMPs in Sema3A signaling	16	2.47e-02	3.99e-02	0.3900	1.89e-02	-0.389000	8.96e-01	7.04e-03
HDACs deacetylate histones	52	3.95e-06	1.50e-05	0.3970	-3.97e-01	0.009870	7.25e-07	9.02e-01
EPH-ephrin mediated repulsion of cells	48	5.92e-05	1.70e-04	0.3620	4.72e-02	-0.359000	5.72e-01	1.66e-05
Signaling by KIT in disease	19	7.69e-06	2.73e-05	0.6590	-2.17e-01	-0.623000	1.02e-01	2.62e-06
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	7.69e-06	2.73e-05	0.6590	-2.17e-01	-0.623000	1.02e-01	2.62e-06
Notch-HLH transcription pathway	28	4.82e-04	1.14e-03	0.4270	-2.10e-02	-0.426000	8.48e-01	9.43e-05
Glutamate binding, activation of AMPA receptors and synaptic plasticity	27	1.76e-02	2.94e-02	0.3040	1.29e-01	-0.275000	2.44e-01	1.33e-02
Trafficking of AMPA receptors	27	1.76e-02	2.94e-02	0.3040	1.29e-01	-0.275000	2.44e-01	1.33e-02
Retrograde transport at the Trans-Golgi-Network	49	1.50e-06	6.22e-06	0.4280	-2.25e-02	-0.427000	7.86e-01	2.29e-07
APC truncation mutants have impaired AXIN binding	14	1.34e-06	5.64e-06	0.8280	-3.48e-01	-0.752000	2.43e-02	1.10e-06
AXIN missense mutants destabilize the destruction complex	14	1.34e-06	5.64e-06	0.8280	-3.48e-01	-0.752000	2.43e-02	1.10e-06
Signaling by AMER1 mutants	14	1.34e-06	5.64e-06	0.8280	-3.48e-01	-0.752000	2.43e-02	1.10e-06
Signaling by APC mutants	14	1.34e-06	5.64e-06	0.8280	-3.48e-01	-0.752000	2.43e-02	1.10e-06
Signaling by AXIN mutants	14	1.34e-06	5.64e-06	0.8280	-3.48e-01	-0.752000	2.43e-02	1.10e-06
Truncations of AMER1 destabilize the destruction complex	14	1.34e-06	5.64e-06	0.8280	-3.48e-01	-0.752000	2.43e-02	1.10e-06
HIV Transcription Initiation	47	5.12e-04	1.20e-03	0.3180	-3.01e-01	0.103000	3.57e-04	2.23e-01
RNA Polymerase II HIV Promoter Escape	47	5.12e-04	1.20e-03	0.3180	-3.01e-01	0.103000	3.57e-04	2.23e-01
RNA Polymerase II Promoter Escape	47	5.12e-04	1.20e-03	0.3180	-3.01e-01	0.103000	3.57e-04	2.23e-01
RNA Polymerase II Transcription Initiation	47	5.12e-04	1.20e-03	0.3180	-3.01e-01	0.103000	3.57e-04	2.23e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	47	5.12e-04	1.20e-03	0.3180	-3.01e-01	0.103000	3.57e-04	2.23e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	47	5.12e-04	1.20e-03	0.3180	-3.01e-01	0.103000	3.57e-04	2.23e-01
ABC transporter disorders	73	2.16e-05	6.79e-05	0.3020	-2.72e-01	0.132000	6.00e-05	5.19e-02
Ion homeostasis	45	1.63e-03	3.42e-03	0.2960	1.42e-01	-0.260000	9.93e-02	2.55e-03
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.79e-02	2.98e-02	0.3040	-2.78e-01	0.123000	1.24e-02	2.68e-01
Frs2-mediated activation	12	2.00e-03	4.07e-03	0.6010	-1.74e-01	-0.575000	2.96e-01	5.63e-04
Processing of Capped Intronless Pre-mRNA	28	6.59e-03	1.22e-02	0.3380	-3.31e-01	0.068900	2.40e-03	5.28e-01
G alpha (12/13) signalling events	75	2.45e-06	9.72e-06	0.3310	7.84e-02	-0.322000	2.40e-01	1.45e-06
Interleukin-2 family signaling	34	5.64e-04	1.31e-03	0.3800	2.00e-02	-0.379000	8.40e-01	1.29e-04
Sensory processing of sound by outer hair cells of the cochlea	43	1.46e-03	3.08e-03	0.3080	1.12e-01	-0.287000	2.06e-01	1.13e-03
NOTCH3 Intracellular Domain Regulates Transcription	22	2.01e-03	4.07e-03	0.4360	-3.76e-02	-0.434000	7.60e-01	4.25e-04
RNA Polymerase III Transcription Termination	23	6.86e-03	1.26e-02	0.3770	-3.77e-01	0.017100	1.76e-03	8.87e-01
Ion transport by P-type ATPases	47	1.65e-03	3.45e-03	0.2900	1.39e-01	-0.254000	9.90e-02	2.59e-03
RUNX3 regulates NOTCH signaling	14	2.15e-03	4.34e-03	0.5510	-1.40e-01	-0.533000	3.64e-01	5.51e-04
Regulation of PTEN stability and activity	67	9.25e-06	3.23e-05	0.3330	-3.26e-01	0.066400	3.90e-06	3.47e-01
Assembly of the ORC complex at the origin of replication	30	2.23e-02	3.65e-02	0.2770	-2.05e-01	0.187000	5.19e-02	7.66e-02
RNA Polymerase I Transcription Termination	30	1.80e-02	2.99e-02	0.2870	-2.48e-01	0.144000	1.86e-02	1.74e-01
Synthesis of PIPs at the plasma membrane	50	3.81e-09	2.82e-08	0.5170	-1.14e-01	-0.504000	1.63e-01	6.82e-10
Deposition of new CENPA-containing nucleosomes at the centromere	44	1.23e-03	2.64e-03	0.3090	-9.58e-02	0.294000	2.71e-01	7.33e-04
Nucleosome assembly	44	1.23e-03	2.64e-03	0.3090	-9.58e-02	0.294000	2.71e-01	7.33e-04
Sema3A PAK dependent Axon repulsion	16	4.75e-03	8.95e-03	0.4780	-8.09e-02	-0.471000	5.76e-01	1.11e-03
MET activates RAS signaling	11	1.73e-02	2.91e-02	0.5030	-1.03e-01	-0.492000	5.55e-01	4.67e-03
Transport of Mature Transcript to Cytoplasm	81	1.61e-07	8.33e-07	0.3550	-3.53e-01	0.036400	4.02e-08	5.71e-01
RUNX2 regulates osteoblast differentiation	22	3.20e-04	7.96e-04	0.5010	-1.02e-01	-0.491000	4.09e-01	6.74e-05
Signaling by ALK	26	4.49e-04	1.07e-03	0.4480	-5.61e-02	-0.444000	6.20e-01	8.71e-05
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	3.20e-07	1.56e-06	0.5900	-5.63e-01	-0.175000	9.25e-08	9.71e-02
NRAGE signals death through JNK	59	1.78e-05	5.80e-05	0.3460	4.38e-02	-0.344000	5.60e-01	4.94e-06
Oncogenic MAPK signaling	75	5.44e-11	5.73e-10	0.4630	-7.07e-02	-0.458000	2.90e-01	6.81e-12
RUNX2 regulates bone development	29	1.61e-04	4.24e-04	0.4520	-6.12e-02	-0.448000	5.69e-01	2.98e-05
Interferon alpha/beta signaling	56	5.90e-05	1.70e-04	0.3350	-3.30e-01	0.054900	1.93e-05	4.77e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	1.35e-04	3.60e-04	0.5290	-5.13e-01	-0.129000	3.08e-05	2.95e-01
Defective pyroptosis	34	7.65e-03	1.40e-02	0.2990	-1.02e-01	0.282000	3.05e-01	4.48e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	2.55e-06	1.01e-05	0.3400	-3.37e-01	0.044700	7.35e-07	5.12e-01
Keratan sulfate biosynthesis	24	5.37e-04	1.25e-03	0.4620	-7.45e-02	-0.456000	5.27e-01	1.09e-04
FCERI mediated Ca+2 mobilization	28	2.54e-05	7.84e-05	0.5100	-1.16e-01	-0.497000	2.88e-01	5.26e-06
Sphingolipid metabolism	84	5.03e-06	1.87e-05	0.3030	8.92e-02	-0.289000	1.58e-01	4.55e-06
Metabolism of amino acids and derivatives	337	1.43e-18	3.12e-17	0.2750	-1.45e-01	0.234000	5.01e-06	1.59e-13
Cellular response to hypoxia	72	5.56e-06	2.03e-05	0.3290	-3.25e-01	0.051400	1.83e-06	4.51e-01
Platelet sensitization by LDL	15	2.23e-05	7.00e-05	0.7110	-2.78e-01	-0.654000	6.24e-02	1.14e-05
Metal ion SLC transporters	22	8.27e-04	1.86e-03	0.4700	-8.64e-02	-0.462000	4.83e-01	1.77e-04
EGR2 and SOX10-mediated initiation of Schwann cell myelination	25	2.63e-06	1.04e-05	0.6000	-1.93e-01	-0.568000	9.51e-02	8.71e-07
SHC1 events in ERBB2 signaling	20	7.50e-03	1.37e-02	0.4050	-2.98e-02	-0.404000	8.18e-01	1.76e-03
Fatty acyl-CoA biosynthesis	35	1.26e-03	2.70e-03	0.3540	1.93e-02	-0.353000	8.44e-01	2.99e-04
Cytoprotection by HMOX1	118	6.08e-08	3.36e-07	0.2980	-2.85e-01	0.086500	8.34e-08	1.04e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	1.18e-02	2.08e-02	0.4660	-8.72e-02	-0.458000	5.72e-01	3.03e-03
Nephrin family interactions	20	9.91e-06	3.42e-05	0.6370	-2.26e-01	-0.596000	8.06e-02	3.99e-06
Aflatoxin activation and detoxification	14	1.43e-03	3.02e-03	0.5720	1.75e-01	0.544000	2.57e-01	4.21e-04
Synthesis of PIPs at the Golgi membrane	15	7.24e-05	2.04e-04	0.6700	-2.52e-01	-0.621000	9.07e-02	3.14e-05
Regulation of signaling by CBL	18	1.73e-05	5.69e-05	0.6560	-2.42e-01	-0.609000	7.58e-02	7.56e-06
Diseases associated with O-glycosylation of proteins	60	3.97e-04	9.56e-04	0.2860	2.68e-01	-0.099200	3.30e-04	1.84e-01
Transcriptional Regulation by MECP2	55	1.44e-04	3.81e-04	0.3220	4.85e-02	-0.318000	5.34e-01	4.39e-05
Cyclin E associated events during G1/S transition	83	5.97e-05	1.71e-04	0.2690	-2.34e-01	0.131000	2.24e-04	3.87e-02
Cyclin A:Cdk2-associated events at S phase entry	85	3.45e-05	1.04e-04	0.2730	-2.46e-01	0.119000	8.74e-05	5.71e-02
RNA Polymerase I Transcription Initiation	47	1.03e-03	2.25e-03	0.3050	-2.98e-01	0.067400	4.08e-04	4.24e-01
Synthesis of DNA	118	2.44e-08	1.50e-07	0.3090	-6.24e-02	0.302000	2.42e-01	1.40e-08
Retinoid metabolism and transport	32	2.19e-02	3.60e-02	0.2710	1.22e-01	-0.242000	2.32e-01	1.77e-02
Downstream signaling events of B Cell Receptor (BCR)	79	1.94e-06	7.93e-06	0.3290	-3.27e-01	0.036500	5.01e-07	5.75e-01
Post NMDA receptor activation events	56	2.51e-07	1.25e-06	0.4300	-6.31e-02	-0.425000	4.14e-01	3.70e-08
Metabolism of carbohydrates	262	7.77e-17	1.39e-15	0.3020	6.63e-02	-0.294000	6.44e-02	2.26e-16
Signaling by FLT3 ITD and TKD mutants	16	1.83e-04	4.76e-04	0.6150	-2.16e-01	-0.576000	1.35e-01	6.60e-05
Interleukin-3, Interleukin-5 and GM-CSF signaling	38	5.07e-06	1.88e-05	0.4700	-9.98e-02	-0.459000	2.87e-01	9.64e-07
MET activates RAP1 and RAC1	11	1.26e-05	4.27e-05	0.8560	-3.99e-01	-0.758000	2.20e-02	1.35e-05
Transcription of the HIV genome	69	3.36e-07	1.63e-06	0.3800	-3.80e-01	-0.021800	4.85e-08	7.54e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	5.16e-06	1.91e-05	0.5320	-1.54e-01	-0.509000	1.45e-01	1.38e-06
Activated NTRK2 signals through FRS2 and FRS3	11	1.73e-02	2.90e-02	0.5060	-1.33e-01	-0.488000	4.45e-01	5.06e-03
DNA Replication	150	4.83e-10	4.31e-09	0.3030	-5.70e-02	0.298000	2.28e-01	2.95e-10
IGF1R signaling cascade	47	2.97e-04	7.47e-04	0.3370	1.76e-02	-0.336000	8.34e-01	6.65e-05
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	47	2.97e-04	7.47e-04	0.3370	1.76e-02	-0.336000	8.34e-01	6.65e-05
mRNA decay by 5’ to 3’ exoribonuclease	15	8.97e-03	1.62e-02	0.4650	-4.54e-01	-0.101000	2.33e-03	4.99e-01
Downstream TCR signaling	88	3.70e-06	1.41e-05	0.3020	-2.97e-01	0.056200	1.48e-06	3.62e-01
Caspase activation via Dependence Receptors in the absence of ligand	10	1.11e-03	2.41e-03	0.6950	-2.83e-01	-0.635000	1.22e-01	5.07e-04
Semaphorin interactions	60	1.52e-05	5.07e-05	0.3500	1.82e-03	-0.350000	9.81e-01	2.75e-06
Activation of RAC1	13	2.04e-05	6.47e-05	0.7700	-3.40e-01	-0.690000	3.36e-02	1.63e-05
Ca2+ pathway	56	1.02e-06	4.44e-06	0.4090	-5.54e-02	-0.405000	4.73e-01	1.55e-07
Dual incision in TC-NER	65	1.26e-03	2.70e-03	0.2510	-2.07e-01	0.140000	3.81e-03	5.01e-02
Constitutive Signaling by EGFRvIII	15	1.70e-02	2.87e-02	0.4310	-7.65e-02	-0.424000	6.08e-01	4.47e-03
Signaling by EGFRvIII in Cancer	15	1.70e-02	2.87e-02	0.4310	-7.65e-02	-0.424000	6.08e-01	4.47e-03
Cellular response to chemical stress	147	7.05e-08	3.84e-07	0.2640	-2.43e-01	0.105000	3.74e-07	2.85e-02
Diseases of carbohydrate metabolism	30	8.99e-03	1.62e-02	0.3200	3.19e-01	-0.026300	2.49e-03	8.03e-01
Collagen formation	80	3.72e-04	9.02e-04	0.2450	1.90e-01	-0.155000	3.33e-03	1.64e-02
RNA Polymerase III Abortive And Retractive Initiation	41	2.69e-04	6.85e-04	0.3660	-3.66e-01	-0.022300	5.06e-05	8.05e-01
RNA Polymerase III Transcription	41	2.69e-04	6.85e-04	0.3660	-3.66e-01	-0.022300	5.06e-05	8.05e-01
Platelet homeostasis	72	1.53e-05	5.10e-05	0.3170	2.66e-02	-0.316000	6.96e-01	3.53e-06
Golgi Associated Vesicle Biogenesis	55	1.01e-06	4.41e-06	0.4140	-6.73e-02	-0.408000	3.88e-01	1.61e-07
Effects of PIP2 hydrolysis	24	1.16e-02	2.05e-02	0.3520	-1.21e-02	-0.351000	9.18e-01	2.89e-03
G2/M Checkpoints	140	1.66e-06	6.85e-06	0.2410	-1.54e-01	0.185000	1.59e-03	1.60e-04
CLEC7A (Dectin-1) signaling	97	9.10e-10	7.66e-09	0.3810	-3.79e-01	-0.039800	1.10e-10	4.98e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	89	1.44e-10	1.42e-09	0.4180	-7.35e-02	-0.411000	2.31e-01	2.00e-11
VxPx cargo-targeting to cilium	19	2.71e-03	5.33e-03	0.4640	-1.13e-01	-0.450000	3.95e-01	6.85e-04
Glutathione conjugation	29	3.04e-04	7.61e-04	0.4380	9.20e-02	0.428000	3.91e-01	6.50e-05
trans-Golgi Network Vesicle Budding	71	2.73e-06	1.07e-05	0.3470	-1.03e-02	-0.347000	8.81e-01	4.36e-07
Negative regulation of the PI3K/AKT network	96	3.32e-11	3.58e-10	0.4150	-7.23e-02	-0.408000	2.21e-01	4.49e-12
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	4.30e-04	1.02e-03	0.2480	-2.19e-01	0.115000	8.21e-04	7.81e-02
Activation of NMDA receptors and postsynaptic events	69	3.22e-08	1.91e-07	0.4140	-7.28e-02	-0.407000	2.96e-01	4.87e-09
Intra-Golgi traffic	43	1.54e-05	5.13e-05	0.4200	-7.85e-02	-0.413000	3.73e-01	2.81e-06
Signaling by SCF-KIT	41	2.32e-07	1.18e-06	0.5100	-1.54e-01	-0.486000	8.79e-02	7.00e-08
Uptake and function of anthrax toxins	11	7.80e-03	1.42e-02	0.5570	-1.91e-01	-0.523000	2.73e-01	2.66e-03
Diseases of metabolism	213	3.97e-09	2.92e-08	0.2360	1.83e-01	-0.149000	4.06e-06	1.86e-04
GPVI-mediated activation cascade	29	3.42e-04	8.41e-04	0.4350	-9.36e-02	-0.425000	3.83e-01	7.42e-05
Interleukin-27 signaling	10	2.01e-02	3.31e-02	0.5230	-1.65e-01	-0.496000	3.66e-01	6.59e-03
Regulation of MECP2 expression and activity	29	8.64e-04	1.94e-03	0.4080	-7.05e-02	-0.401000	5.11e-01	1.82e-04
Post-translational protein phosphorylation	85	5.22e-04	1.22e-03	0.2320	1.66e-01	-0.162000	7.97e-03	9.67e-03
Signal transduction by L1	21	3.76e-06	1.44e-05	0.6500	-2.66e-01	-0.593000	3.49e-02	2.54e-06
Positive epigenetic regulation of rRNA expression	67	3.97e-04	9.56e-04	0.2730	-2.66e-01	0.060500	1.64e-04	3.92e-01
Metabolism of fat-soluble vitamins	36	1.64e-02	2.77e-02	0.2690	6.53e-02	-0.261000	4.98e-01	6.67e-03
Gap-filling DNA repair synthesis and ligation in TC-NER	64	3.46e-03	6.65e-03	0.2320	-1.84e-01	0.142000	1.10e-02	4.96e-02
Interleukin-6 signaling	11	3.64e-04	8.89e-04	0.7160	-3.18e-01	-0.642000	6.81e-02	2.26e-04
HDMs demethylate histones	22	1.14e-08	7.46e-08	0.7710	-3.58e-01	-0.683000	3.61e-03	2.94e-08
Opioid Signalling	78	2.80e-09	2.13e-08	0.4170	-8.55e-02	-0.408000	1.92e-01	4.59e-10
IRS-related events triggered by IGF1R	46	6.60e-04	1.52e-03	0.3250	-3.13e-03	-0.325000	9.71e-01	1.37e-04
Formation of RNA Pol II elongation complex	57	2.17e-06	8.78e-06	0.3950	-3.90e-01	-0.068100	3.60e-07	3.74e-01
RNA Polymerase II Transcription Elongation	57	2.17e-06	8.78e-06	0.3950	-3.90e-01	-0.068100	3.60e-07	3.74e-01
Insulin receptor signalling cascade	48	8.22e-05	2.26e-04	0.3640	-4.07e-02	-0.362000	6.25e-01	1.45e-05
Host Interactions of HIV factors	124	3.03e-10	2.84e-09	0.3450	-3.44e-01	-0.024300	3.60e-11	6.41e-01
Interleukin-1 signaling	95	4.85e-07	2.29e-06	0.3190	-3.19e-01	0.000406	7.91e-08	9.95e-01
Vasopressin regulates renal water homeostasis via Aquaporins	35	1.02e-02	1.82e-02	0.2920	2.79e-02	-0.291000	7.75e-01	2.92e-03
Signaling by Erythropoietin	24	2.94e-05	8.95e-05	0.5530	-1.99e-01	-0.517000	9.19e-02	1.18e-05
Cell surface interactions at the vascular wall	97	1.19e-06	5.16e-06	0.3040	1.38e-02	-0.304000	8.14e-01	2.29e-07
Protein methylation	15	2.89e-03	5.67e-03	0.5230	-4.93e-01	-0.175000	9.48e-04	2.40e-01
CTLA4 inhibitory signaling	17	1.05e-05	3.60e-05	0.6930	-3.05e-01	-0.623000	2.93e-02	8.78e-06
tRNA modification in the nucleus and cytosol	43	2.51e-02	4.05e-02	0.2290	-1.26e-01	0.191000	1.52e-01	3.04e-02
Separation of Sister Chromatids	168	2.25e-07	1.15e-06	0.2380	-2.15e-01	0.102000	1.48e-06	2.29e-02
RHO GTPases Activate WASPs and WAVEs	36	8.07e-09	5.40e-08	0.6060	-2.40e-01	-0.556000	1.28e-02	7.57e-09
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	9.31e-06	3.24e-05	0.4670	-1.32e-01	-0.448000	1.66e-01	2.39e-06
Zinc transporters	14	1.14e-03	2.48e-03	0.5850	-2.24e-01	-0.540000	1.46e-01	4.62e-04
Interleukin-12 signaling	43	9.30e-04	2.06e-03	0.3290	-3.29e-01	-0.012800	1.90e-04	8.85e-01
Signaling by NOTCH1	72	2.46e-07	1.23e-06	0.3800	-5.90e-02	-0.375000	3.86e-01	3.69e-08
Cell death signalling via NRAGE, NRIF and NADE	76	7.93e-05	2.20e-04	0.2840	3.34e-02	-0.282000	6.15e-01	2.12e-05
Signaling by Receptor Tyrosine Kinases	468	1.35e-34	6.59e-33	0.3370	-2.07e-02	-0.336000	4.42e-01	9.18e-36
Heme signaling	42	5.08e-10	4.45e-09	0.6010	-2.39e-01	-0.552000	7.42e-03	6.08e-10
ERK/MAPK targets	22	2.93e-08	1.77e-07	0.7510	-3.52e-01	-0.663000	4.27e-03	7.08e-08
WNT ligand biogenesis and trafficking	24	1.31e-02	2.27e-02	0.3490	-3.67e-02	-0.347000	7.55e-01	3.23e-03
Ephrin signaling	19	3.10e-05	9.41e-05	0.6230	-2.58e-01	-0.567000	5.18e-02	1.86e-05
GAB1 signalosome	15	8.90e-04	1.99e-03	0.5760	-2.23e-01	-0.531000	1.35e-01	3.72e-04
Aquaporin-mediated transport	37	1.33e-02	2.31e-02	0.2750	3.27e-02	-0.273000	7.31e-01	4.04e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	34	1.49e-02	2.56e-02	0.2840	2.12e-02	-0.283000	8.30e-01	4.24e-03
PI Metabolism	77	8.85e-13	1.18e-11	0.5030	-1.70e-01	-0.474000	1.01e-02	6.17e-13
RET signaling	37	1.90e-05	6.12e-05	0.4520	-1.29e-01	-0.434000	1.74e-01	4.99e-06
Mitotic Telophase/Cytokinesis	13	1.14e-03	2.48e-03	0.6090	-2.51e-01	-0.554000	1.17e-01	5.37e-04
TICAM1,TRAF6-dependent induction of TAK1 complex	11	1.29e-02	2.25e-02	0.5280	-4.93e-01	-0.189000	4.66e-03	2.77e-01
Constitutive Signaling by Aberrant PI3K in Cancer	62	1.38e-05	4.64e-05	0.3500	-4.45e-02	-0.347000	5.45e-01	2.27e-06
Signaling by ERBB4	50	5.80e-03	1.08e-02	0.2570	5.09e-02	-0.252000	5.33e-01	2.08e-03
HATs acetylate histones	99	3.21e-09	2.40e-08	0.3680	-3.62e-01	-0.060900	4.50e-10	2.95e-01
Signaling by EGFR	48	9.16e-07	4.02e-06	0.4490	-1.29e-01	-0.430000	1.21e-01	2.46e-07
RNA polymerase II transcribes snRNA genes	71	1.96e-07	1.01e-06	0.3870	-3.79e-01	-0.077900	3.36e-08	2.56e-01
RNA Polymerase III Transcription Initiation	36	5.80e-03	1.08e-02	0.3080	-3.08e-01	-0.007570	1.36e-03	9.37e-01
Assembly of collagen fibrils and other multimeric structures	50	2.30e-02	3.74e-02	0.2140	1.73e-01	-0.127000	3.48e-02	1.19e-01
Senescence-Associated Secretory Phenotype (SASP)	71	3.18e-03	6.20e-03	0.2240	-2.02e-01	0.097300	3.30e-03	1.56e-01
tRNA processing	124	9.58e-05	2.61e-04	0.2140	-1.25e-01	0.174000	1.66e-02	8.40e-04
Antigen processing-Cross presentation	96	3.24e-04	8.00e-04	0.2280	-2.11e-01	0.086600	3.43e-04	1.42e-01
B-WICH complex positively regulates rRNA expression	52	1.67e-02	2.82e-02	0.2200	-1.95e-01	0.102000	1.50e-02	2.02e-01
Peptide hormone metabolism	65	2.67e-03	5.26e-03	0.2400	6.60e-02	-0.231000	3.58e-01	1.28e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	95	9.66e-04	2.13e-03	0.2110	1.32e-01	-0.164000	2.59e-02	5.58e-03
FLT3 signaling in disease	28	1.32e-03	2.82e-03	0.4040	-9.71e-02	-0.393000	3.74e-01	3.22e-04
Signaling by BRAF and RAF1 fusions	58	2.73e-07	1.34e-06	0.4260	-1.15e-01	-0.410000	1.31e-01	6.59e-08
Regulation of RUNX1 Expression and Activity	18	1.01e-04	2.75e-04	0.6030	-2.52e-01	-0.547000	6.39e-02	5.81e-05
Hemostasis	485	3.73e-27	1.33e-25	0.2900	4.08e-03	-0.290000	8.77e-01	5.28e-28
Uptake and actions of bacterial toxins	28	2.69e-02	4.32e-02	0.2920	1.80e-04	-0.292000	9.99e-01	7.41e-03
Deadenylation-dependent mRNA decay	53	2.51e-07	1.25e-06	0.4480	-4.27e-01	-0.135000	7.48e-08	9.02e-02
COPII-mediated vesicle transport	66	2.86e-07	1.40e-06	0.3970	-9.43e-02	-0.386000	1.85e-01	5.78e-08
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	7.08e-11	7.20e-10	0.5490	-2.15e-01	-0.505000	5.84e-03	9.09e-11
Downstream signal transduction	29	5.13e-09	3.61e-08	0.6860	-3.18e-01	-0.608000	3.03e-03	1.44e-08
Epigenetic regulation of gene expression	109	2.54e-05	7.84e-05	0.2500	-2.46e-01	0.043400	8.89e-06	4.34e-01
Response to elevated platelet cytosolic Ca2+	114	1.37e-05	4.60e-05	0.2520	4.01e-02	-0.249000	4.59e-01	4.48e-06
Signaling by WNT in cancer	33	7.53e-08	4.09e-07	0.5950	-2.51e-01	-0.539000	1.27e-02	8.22e-08
Nucleotide Excision Repair	110	2.62e-04	6.70e-04	0.2160	-1.94e-01	0.093000	4.24e-04	9.17e-02
Synthesis of PIPs at the late endosome membrane	11	1.09e-04	2.94e-04	0.7710	-3.83e-01	-0.670000	2.78e-02	1.20e-04
STAT5 activation downstream of FLT3 ITD mutants	10	2.20e-03	4.43e-03	0.6610	-3.03e-01	-0.588000	9.75e-02	1.28e-03
Sensory processing of sound by inner hair cells of the cochlea	57	1.30e-02	2.26e-02	0.2180	8.48e-02	-0.200000	2.68e-01	8.83e-03
Degradation of beta-catenin by the destruction complex	83	2.03e-06	8.29e-06	0.3270	-3.25e-01	-0.040200	3.10e-07	5.27e-01
Signaling by high-kinase activity BRAF mutants	31	8.07e-03	1.46e-02	0.3240	-3.76e-02	-0.322000	7.17e-01	1.91e-03
Signaling by RAF1 mutants	35	8.89e-04	1.99e-03	0.3720	-7.94e-02	-0.363000	4.16e-01	2.01e-04
Integrin signaling	24	1.21e-04	3.25e-04	0.5150	-1.94e-01	-0.477000	9.98e-02	5.16e-05
Signaling by NTRK3 (TRKC)	16	5.33e-03	9.99e-03	0.4800	-1.67e-01	-0.450000	2.48e-01	1.84e-03
Factors involved in megakaryocyte development and platelet production	115	9.18e-06	3.21e-05	0.2560	2.62e-02	-0.255000	6.27e-01	2.28e-06
RNA Polymerase II Pre-transcription Events	80	8.69e-07	3.86e-06	0.3450	-3.40e-01	-0.059400	1.40e-07	3.58e-01
EPH-Ephrin signaling	91	2.93e-08	1.77e-07	0.3620	-7.37e-02	-0.355000	2.24e-01	4.91e-09
Signaling by Rho GTPases	625	3.81e-42	3.72e-40	0.3250	-4.17e-02	-0.322000	7.44e-02	2.52e-43
Erythropoietin activates RAS	13	1.70e-03	3.55e-03	0.5910	-2.54e-01	-0.534000	1.13e-01	8.63e-04
PI3K Cascade	39	5.46e-03	1.02e-02	0.2990	-1.85e-02	-0.299000	8.41e-01	1.25e-03
TP53 Regulates Transcription of DNA Repair Genes	61	1.91e-03	3.91e-03	0.2590	-2.58e-01	0.021100	4.89e-04	7.75e-01
CD209 (DC-SIGN) signaling	19	8.89e-05	2.43e-04	0.5910	-2.55e-01	-0.534000	5.46e-02	5.65e-05
p75 NTR receptor-mediated signalling	94	1.25e-06	5.36e-06	0.3130	-3.24e-02	-0.311000	5.87e-01	1.85e-07
Activation of BAD and translocation to mitochondria	15	1.24e-02	2.17e-02	0.4530	-1.50e-01	-0.428000	3.14e-01	4.14e-03
Collagen biosynthesis and modifying enzymes	58	1.65e-02	2.80e-02	0.2100	1.92e-01	-0.085000	1.16e-02	2.63e-01
MHC class II antigen presentation	97	5.64e-05	1.63e-04	0.2570	1.95e-02	-0.256000	7.40e-01	1.29e-05
NCAM signaling for neurite out-growth	54	6.65e-03	1.23e-02	0.2450	3.27e-02	-0.243000	6.77e-01	2.02e-03
IRS-mediated signalling	43	2.19e-03	4.41e-03	0.3100	-3.32e-02	-0.308000	7.07e-01	4.66e-04
Platelet degranulation	109	3.81e-05	1.13e-04	0.2460	3.03e-02	-0.244000	5.85e-01	1.04e-05
FGFR1 mutant receptor activation	29	1.54e-03	3.23e-03	0.3940	-1.05e-01	-0.380000	3.27e-01	4.03e-04
Signaling by ALK fusions and activated point mutants	55	3.21e-11	3.49e-10	0.5590	-2.34e-01	-0.508000	2.65e-03	7.25e-11
Signaling by ALK in cancer	55	3.21e-11	3.49e-10	0.5590	-2.34e-01	-0.508000	2.65e-03	7.25e-11
TICAM1, RIP1-mediated IKK complex recruitment	18	1.02e-02	1.82e-02	0.4220	-4.02e-01	-0.128000	3.17e-03	3.46e-01
G1/S Transition	131	1.08e-04	2.91e-04	0.2090	-8.09e-02	0.192000	1.10e-01	1.45e-04
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	641	1.00e-42	1.05e-40	0.3240	-4.79e-02	-0.320000	3.82e-02	7.99e-44
p75NTR signals via NF-kB	16	5.94e-03	1.11e-02	0.4750	-4.43e-01	-0.171000	2.14e-03	2.36e-01
Transcriptional regulation by small RNAs	68	1.64e-04	4.31e-04	0.2930	-2.93e-01	-0.021000	2.99e-05	7.64e-01
Hedgehog ‘off’ state	95	6.08e-04	1.41e-03	0.2230	-2.15e-01	0.056300	2.86e-04	3.43e-01
Neurotransmitter receptors and postsynaptic signal transmission	152	3.97e-07	1.90e-06	0.2520	2.03e-02	-0.251000	6.66e-01	8.79e-08
Sensory processing of sound	62	1.56e-02	2.65e-02	0.2040	8.63e-02	-0.185000	2.40e-01	1.18e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression	26	8.42e-06	2.97e-05	0.5660	-2.41e-01	-0.511000	3.31e-02	6.32e-06
Platelet activation, signaling and aggregation	224	1.18e-15	1.99e-14	0.3240	-5.07e-02	-0.320000	1.91e-01	1.31e-16
Fanconi Anemia Pathway	36	3.63e-03	6.96e-03	0.3260	5.24e-02	0.322000	5.87e-01	8.28e-04
HIV Infection	222	6.65e-18	1.35e-16	0.3510	-3.43e-01	-0.074100	1.09e-18	5.68e-02
Signaling by ERBB2 in Cancer	24	1.75e-02	2.93e-02	0.3400	-6.50e-02	-0.334000	5.82e-01	4.66e-03
Regulation of actin dynamics for phagocytic cup formation	58	9.15e-10	7.66e-09	0.5040	-1.96e-01	-0.464000	9.64e-03	9.31e-10
FCGR3A-mediated phagocytosis	56	1.53e-12	1.94e-11	0.5890	-2.61e-01	-0.528000	7.44e-04	7.96e-12
Leishmania phagocytosis	56	1.53e-12	1.94e-11	0.5890	-2.61e-01	-0.528000	7.44e-04	7.96e-12
Parasite infection	56	1.53e-12	1.94e-11	0.5890	-2.61e-01	-0.528000	7.44e-04	7.96e-12
Cholesterol biosynthesis	24	7.17e-04	1.63e-03	0.4610	-4.31e-01	-0.164000	2.57e-04	1.65e-01
Regulation of insulin secretion	65	1.80e-03	3.72e-03	0.2530	1.50e-02	-0.252000	8.34e-01	4.39e-04
Cell Cycle Checkpoints	260	2.55e-07	1.27e-06	0.1890	-1.46e-01	0.121000	5.16e-05	8.03e-04
MAPK3 (ERK1) activation	10	2.24e-02	3.67e-02	0.5190	-2.09e-01	-0.475000	2.52e-01	9.29e-03
Gastrin-CREB signalling pathway via PKC and MAPK	17	1.16e-05	3.97e-05	0.6920	-3.40e-01	-0.603000	1.52e-02	1.66e-05
COPI-independent Golgi-to-ER retrograde traffic	33	5.40e-06	1.97e-05	0.5110	-2.05e-01	-0.468000	4.15e-02	3.30e-06
RAF activation	33	2.44e-06	9.72e-06	0.5270	-2.18e-01	-0.480000	3.02e-02	1.78e-06
Neurexins and neuroligins	49	6.07e-03	1.13e-02	0.2630	-1.80e-03	-0.263000	9.83e-01	1.45e-03
Caspase activation via extrinsic apoptotic signalling pathway	25	2.09e-02	3.43e-02	0.3250	-5.92e-02	-0.320000	6.08e-01	5.61e-03
Signaling by NOTCH4	81	4.55e-03	8.62e-03	0.2040	-1.93e-01	0.067300	2.67e-03	2.95e-01
SARS-CoV-1 Infection	49	1.21e-02	2.11e-02	0.2430	1.81e-02	-0.242000	8.26e-01	3.37e-03
Signal regulatory protein family interactions	11	2.40e-03	4.78e-03	0.6260	-2.94e-01	-0.553000	9.18e-02	1.48e-03
CD28 co-stimulation	29	6.81e-05	1.93e-04	0.4840	-1.88e-01	-0.446000	8.03e-02	3.20e-05
PI3K/AKT Signaling in Cancer	89	1.12e-08	7.41e-08	0.3790	-1.06e-01	-0.364000	8.44e-02	2.99e-09
TCR signaling	108	1.86e-05	6.01e-05	0.2590	-2.59e-01	-0.003220	3.28e-06	9.54e-01
Signaling by FGFR4 in disease	11	9.34e-03	1.68e-02	0.5500	-2.40e-01	-0.495000	1.68e-01	4.47e-03
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	9.27e-04	2.06e-03	0.4350	-1.52e-01	-0.407000	1.78e-01	3.25e-04
Role of phospholipids in phagocytosis	22	5.81e-03	1.08e-02	0.4050	-1.30e-01	-0.384000	2.92e-01	1.84e-03
G2/M Transition	181	1.76e-05	5.73e-05	0.1950	-1.80e-01	0.073800	2.92e-05	8.67e-02
Nuclear Receptor transcription pathway	46	2.21e-03	4.44e-03	0.3010	-4.40e-02	-0.297000	6.06e-01	4.80e-04
MET receptor recycling	10	9.22e-03	1.66e-02	0.5790	-2.63e-01	-0.515000	1.50e-01	4.77e-03
Global Genome Nucleotide Excision Repair (GG-NER)	84	1.09e-02	1.93e-02	0.1810	-1.50e-01	0.102000	1.78e-02	1.04e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	179	4.86e-23	1.43e-21	0.4510	-1.67e-01	-0.419000	1.14e-04	3.49e-22
Extra-nuclear estrogen signaling	66	1.59e-10	1.53e-09	0.4930	-1.99e-01	-0.451000	5.14e-03	2.35e-10
Mitotic G2-G2/M phases	183	2.48e-05	7.69e-05	0.1900	-1.74e-01	0.076600	4.85e-05	7.39e-02
ER to Golgi Anterograde Transport	131	1.75e-17	3.37e-16	0.4570	-1.73e-01	-0.423000	6.41e-04	5.72e-17
Lysosphingolipid and LPA receptors	11	6.23e-03	1.15e-02	0.5740	-5.11e-01	-0.261000	3.31e-03	1.34e-01
Tie2 Signaling	17	1.29e-03	2.76e-03	0.5280	-2.28e-01	-0.476000	1.04e-01	6.72e-04
Transport to the Golgi and subsequent modification	161	5.55e-21	1.40e-19	0.4530	-1.71e-01	-0.420000	1.78e-04	3.44e-20
Formation of Incision Complex in GG-NER	43	1.71e-02	2.88e-02	0.2510	-2.51e-01	-0.003050	4.47e-03	9.72e-01
Cardiac conduction	107	3.57e-03	6.85e-03	0.1800	9.28e-02	-0.154000	9.71e-02	5.88e-03
Degradation of the extracellular matrix	90	2.72e-04	6.91e-04	0.2460	1.73e-05	-0.246000	1.00e+00	5.46e-05
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	2.38e-02	3.86e-02	0.3080	-3.03e-01	-0.057100	6.51e-03	6.08e-01
CD28 dependent PI3K/Akt signaling	18	2.57e-02	4.14e-02	0.3770	-1.14e-01	-0.359000	4.02e-01	8.34e-03
Fcgamma receptor (FCGR) dependent phagocytosis	82	9.39e-14	1.38e-12	0.5110	-2.19e-01	-0.461000	6.15e-04	4.84e-13
Signalling to ERKs	33	7.38e-05	2.07e-04	0.4520	-1.75e-01	-0.417000	8.18e-02	3.44e-05
Late Phase of HIV Life Cycle	135	1.15e-13	1.65e-12	0.3940	-3.72e-01	-0.131000	8.16e-14	8.59e-03
Cellular responses to stress	671	3.91e-26	1.33e-24	0.2440	-2.43e-01	-0.003840	4.01e-27	8.65e-01
Mitotic Metaphase and Anaphase	229	4.59e-07	2.18e-06	0.2030	-1.99e-01	0.040400	2.22e-07	2.92e-01
Cellular responses to stimuli	680	9.62e-25	2.94e-23	0.2350	-2.35e-01	0.003420	1.35e-25	8.79e-01
Sphingolipid de novo biosynthesis	42	6.52e-05	1.86e-04	0.4020	-1.40e-01	-0.377000	1.17e-01	2.36e-05
HIV Life Cycle	147	6.78e-14	1.01e-12	0.3810	-3.61e-01	-0.123000	4.29e-14	9.88e-03
Membrane Trafficking	577	6.20e-62	4.54e-59	0.4190	-1.53e-01	-0.390000	3.46e-10	4.07e-58
SARS-CoV-2 Infection	70	6.78e-06	2.42e-05	0.3440	-9.37e-02	-0.331000	1.75e-01	1.66e-06
Mitotic Anaphase	228	6.05e-07	2.80e-06	0.2010	-1.97e-01	0.039800	2.84e-07	3.00e-01
Interleukin-1 family signaling	124	5.14e-06	1.90e-05	0.2570	-2.56e-01	-0.020900	8.01e-07	6.88e-01
Mitotic G1 phase and G1/S transition	147	9.65e-04	2.13e-03	0.1700	-9.14e-02	0.144000	5.56e-02	2.62e-03
Signaling by NOTCH3	46	2.91e-02	4.62e-02	0.2250	1.07e-02	-0.224000	9.00e-01	8.43e-03
SLC-mediated transmembrane transport	196	5.87e-06	2.13e-05	0.1990	4.05e-02	-0.195000	3.28e-01	2.60e-06
Vesicle-mediated transport	606	5.44e-58	1.99e-55	0.3950	-1.36e-01	-0.371000	1.01e-08	3.43e-55
Neuronal System	326	3.89e-10	3.56e-09	0.2080	2.80e-02	-0.207000	3.84e-01	1.38e-10
Circadian Clock	67	1.05e-13	1.52e-12	0.5650	-2.65e-01	-0.499000	1.72e-04	1.54e-12
C-type lectin receptors (CLRs)	123	4.96e-08	2.79e-07	0.3070	-3.00e-01	-0.066700	8.92e-09	2.01e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	3.22e-04	7.96e-04	0.3120	-7.07e-02	-0.304000	3.56e-01	7.17e-05
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	3.22e-04	7.96e-04	0.3120	-7.07e-02	-0.304000	3.56e-01	7.17e-05
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	3.22e-04	7.96e-04	0.3120	-7.07e-02	-0.304000	3.56e-01	7.17e-05
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	3.22e-04	7.96e-04	0.3120	-7.07e-02	-0.304000	3.56e-01	7.17e-05
Signaling by NOTCH1 in Cancer	57	3.22e-04	7.96e-04	0.3120	-7.07e-02	-0.304000	3.56e-01	7.17e-05
Interleukin-4 and Interleukin-13 signaling	95	1.69e-04	4.41e-04	0.2480	-1.48e-02	-0.247000	8.03e-01	3.10e-05
Anti-inflammatory response favouring Leishmania parasite infection	106	3.70e-04	8.98e-04	0.2220	1.06e-02	-0.221000	8.51e-01	8.24e-05
Leishmania parasite growth and survival	106	3.70e-04	8.98e-04	0.2220	1.06e-02	-0.221000	8.51e-01	8.24e-05
Negative regulation of MAPK pathway	42	1.15e-04	3.09e-04	0.3900	-1.36e-01	-0.366000	1.29e-01	4.12e-05
MAPK6/MAPK4 signaling	87	6.31e-05	1.80e-04	0.2750	-2.72e-01	-0.042600	1.14e-05	4.92e-01
Regulation of KIT signaling	15	2.63e-03	5.20e-03	0.5320	-2.44e-01	-0.473000	1.02e-01	1.52e-03
ABC-family proteins mediated transport	97	7.92e-03	1.44e-02	0.1770	-1.64e-01	0.064600	5.15e-03	2.72e-01
Chromosome Maintenance	109	6.48e-04	1.49e-03	0.2100	-1.99e-02	0.209000	7.20e-01	1.66e-04
Glycolysis	67	4.30e-08	2.46e-07	0.4240	-1.63e-01	-0.391000	2.10e-02	3.10e-08
MAPK targets/ Nuclear events mediated by MAP kinases	31	4.32e-08	2.46e-07	0.6270	-3.15e-01	-0.542000	2.42e-03	1.73e-07
Transmission across Chemical Synapses	212	1.91e-06	7.82e-06	0.2010	2.83e-02	-0.199000	4.77e-01	5.83e-07
PCP/CE pathway	90	1.06e-04	2.85e-04	0.2630	-2.61e-01	-0.033800	1.90e-05	5.79e-01
NGF-stimulated transcription	38	2.67e-03	5.26e-03	0.3290	-3.17e-01	-0.090300	7.27e-04	3.35e-01
GPCR downstream signalling	420	2.62e-11	2.95e-10	0.1950	3.28e-02	-0.192000	2.48e-01	1.48e-11
Cell-extracellular matrix interactions	16	2.20e-06	8.89e-06	0.7660	-4.18e-01	-0.642000	3.77e-03	8.63e-06
Signaling by GPCR	474	1.38e-12	1.80e-11	0.1940	3.01e-02	-0.192000	2.62e-01	7.40e-13
Leishmania infection	187	6.95e-11	7.12e-10	0.2940	-6.54e-02	-0.287000	1.23e-01	1.23e-11
S Phase	160	1.10e-03	2.41e-03	0.1620	-8.21e-02	0.140000	7.30e-02	2.30e-03
PPARA activates gene expression	108	4.30e-10	3.89e-09	0.3750	-1.30e-01	-0.352000	1.91e-02	2.56e-10
NOTCH1 Intracellular Domain Regulates Transcription	47	4.53e-05	1.33e-04	0.3880	-1.40e-01	-0.361000	9.64e-02	1.82e-05
Integration of energy metabolism	93	3.60e-06	1.38e-05	0.3060	-7.54e-02	-0.296000	2.09e-01	7.77e-07
Telomere Maintenance	84	6.86e-03	1.26e-02	0.1960	-2.67e-02	0.194000	6.72e-01	2.10e-03
ADORA2B mediated anti-inflammatory cytokines production	81	1.23e-02	2.16e-02	0.1870	3.66e-02	-0.183000	5.69e-01	4.42e-03
Regulation of lipid metabolism by PPARalpha	110	5.92e-10	5.16e-09	0.3690	-1.28e-01	-0.346000	2.06e-02	3.40e-10
Paradoxical activation of RAF signaling by kinase inactive BRAF	39	3.33e-03	6.44e-03	0.3190	-8.88e-02	-0.306000	3.37e-01	9.24e-04
Signaling by RAS mutants	39	3.33e-03	6.44e-03	0.3190	-8.88e-02	-0.306000	3.37e-01	9.24e-04
Signaling by moderate kinase activity BRAF mutants	39	3.33e-03	6.44e-03	0.3190	-8.88e-02	-0.306000	3.37e-01	9.24e-04
Signaling downstream of RAS mutants	39	3.33e-03	6.44e-03	0.3190	-8.88e-02	-0.306000	3.37e-01	9.24e-04
Muscle contraction	159	2.29e-03	4.60e-03	0.1530	9.71e-02	-0.118000	3.46e-02	1.02e-02
Viral Messenger RNA Synthesis	44	7.31e-05	2.05e-04	0.3910	-3.62e-01	-0.147000	3.18e-05	9.05e-02
Signaling by FGFR1 in disease	36	2.45e-04	6.25e-04	0.4050	-1.58e-01	-0.372000	1.01e-01	1.10e-04
Glucagon signaling in metabolic regulation	26	1.48e-02	2.53e-02	0.3370	-1.06e-01	-0.320000	3.49e-01	4.76e-03
Signaling by NTRK2 (TRKB)	24	3.09e-03	6.03e-03	0.4130	-1.67e-01	-0.378000	1.58e-01	1.33e-03
Transcriptional regulation by RUNX2	115	1.17e-04	3.14e-04	0.2300	-2.30e-01	-0.019500	2.10e-05	7.18e-01
Signal Transduction	2157	1.77e-97	2.59e-94	0.2780	-6.13e-02	-0.271000	2.50e-06	3.81e-97
COPI-mediated anterograde transport	79	5.32e-14	8.12e-13	0.5270	-2.53e-01	-0.462000	1.02e-04	1.17e-12
Glucose metabolism	84	5.55e-05	1.61e-04	0.2840	-6.68e-02	-0.276000	2.90e-01	1.20e-05
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	17	3.12e-03	6.08e-03	0.4930	-2.28e-01	-0.437000	1.03e-01	1.82e-03
FOXO-mediated transcription	58	5.71e-04	1.33e-03	0.2990	-8.04e-02	-0.288000	2.89e-01	1.46e-04
Interleukin-12 family signaling	51	2.90e-03	5.68e-03	0.2810	-2.74e-01	-0.065900	7.23e-04	4.16e-01
G alpha (s) signalling events	92	1.54e-02	2.62e-02	0.1700	4.28e-02	-0.164000	4.78e-01	6.43e-03
DAP12 signaling	26	4.58e-03	8.65e-03	0.3830	-1.47e-01	-0.354000	1.96e-01	1.80e-03
Platelet Aggregation (Plug Formation)	29	1.06e-03	2.32e-03	0.4100	-1.67e-01	-0.374000	1.19e-01	4.91e-04
Nuclear events stimulated by ALK signaling in cancer	19	2.25e-03	4.51e-03	0.4790	-4.26e-01	-0.219000	1.31e-03	9.79e-02
Costimulation by the CD28 family	57	2.82e-04	7.13e-04	0.3170	-9.74e-02	-0.301000	2.03e-01	8.23e-05
FLT3 Signaling	35	7.57e-05	2.12e-04	0.4400	-1.92e-01	-0.396000	4.94e-02	5.10e-05
Asparagine N-linked glycosylation	278	3.87e-24	1.16e-22	0.3720	-1.41e-01	-0.344000	4.89e-05	4.83e-23
Signaling by Insulin receptor	71	6.92e-03	1.27e-02	0.2170	-1.72e-02	-0.216000	8.02e-01	1.61e-03
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	35	2.24e-03	4.49e-03	0.3510	-1.29e-01	-0.326000	1.87e-01	8.33e-04
STING mediated induction of host immune responses	15	1.53e-02	2.62e-02	0.4460	-3.97e-01	-0.203000	7.74e-03	1.73e-01
FOXO-mediated transcription of cell death genes	15	2.32e-03	4.63e-03	0.5390	-4.65e-01	-0.272000	1.80e-03	6.80e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	2.47e-05	7.69e-05	0.5520	-2.82e-01	-0.475000	1.47e-02	3.91e-05
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	31	2.48e-05	7.69e-05	0.4950	-4.33e-01	-0.241000	3.02e-05	2.02e-02
Metabolism of non-coding RNA	53	1.47e-04	3.89e-04	0.3430	-3.19e-01	-0.127000	5.99e-05	1.09e-01
snRNP Assembly	53	1.47e-04	3.89e-04	0.3430	-3.19e-01	-0.127000	5.99e-05	1.09e-01
Budding and maturation of HIV virion	28	3.35e-03	6.48e-03	0.3800	-3.47e-01	-0.156000	1.48e-03	1.54e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	56	2.54e-02	4.09e-02	0.2100	-2.09e-01	-0.019100	6.72e-03	8.04e-01
Mitotic Spindle Checkpoint	109	2.66e-02	4.27e-02	0.1440	-1.31e-01	0.059000	1.79e-02	2.87e-01
FCERI mediated MAPK activation	29	8.16e-04	1.84e-03	0.4180	-1.85e-01	-0.375000	8.42e-02	4.72e-04
Protein-protein interactions at synapses	78	8.10e-05	2.24e-04	0.2910	-8.76e-02	-0.277000	1.81e-01	2.29e-05
tRNA processing in the nucleus	59	6.94e-03	1.27e-02	0.2410	-2.36e-01	-0.048200	1.73e-03	5.22e-01
Regulation of FOXO transcriptional activity by acetylation	10	1.20e-02	2.11e-02	0.5640	-2.95e-01	-0.481000	1.06e-01	8.47e-03
HSF1-dependent transactivation	31	6.44e-03	1.19e-02	0.3390	-1.29e-01	-0.314000	2.13e-01	2.49e-03
Cargo recognition for clathrin-mediated endocytosis	97	6.57e-08	3.60e-07	0.3480	-1.36e-01	-0.320000	2.06e-02	4.93e-08
Interleukin-35 Signalling	12	2.94e-02	4.67e-02	0.4590	-2.21e-01	-0.402000	1.86e-01	1.58e-02
Ub-specific processing proteases	175	4.13e-11	4.42e-10	0.3110	-2.91e-01	-0.110000	2.99e-11	1.23e-02
Ion channel transport	152	1.60e-02	2.72e-02	0.1290	7.76e-02	-0.103000	9.86e-02	2.83e-02
RHOBTB1 GTPase cycle	23	2.21e-04	5.67e-04	0.5130	-4.41e-01	-0.261000	2.47e-04	3.00e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.31e-03	2.80e-03	0.6320	-3.49e-01	-0.527000	3.66e-02	1.57e-03
Death Receptor Signalling	137	2.74e-08	1.67e-07	0.3000	-1.03e-01	-0.281000	3.72e-02	1.29e-08
PTEN Regulation	140	1.48e-08	9.52e-08	0.3020	-2.83e-01	-0.105000	7.59e-09	3.12e-02
Receptor-type tyrosine-protein phosphatases	18	1.03e-02	1.82e-02	0.4270	-2.00e-01	-0.377000	1.42e-01	5.62e-03
DAP12 interactions	33	2.83e-04	7.15e-04	0.4210	-1.97e-01	-0.372000	5.04e-02	2.15e-04
Signaling by ERBB2	48	2.31e-03	4.62e-03	0.2990	-1.05e-01	-0.280000	2.09e-01	8.02e-04
Gene Silencing by RNA	95	1.97e-04	5.09e-04	0.2500	-2.41e-01	-0.066800	4.88e-05	2.60e-01
Removal of the Flap Intermediate	14	1.09e-02	1.93e-02	0.4820	4.16e-01	0.242000	6.98e-03	1.17e-01
Postmitotic nuclear pore complex (NPC) reformation	27	4.27e-05	1.26e-04	0.5180	-4.42e-01	-0.270000	6.92e-05	1.53e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	1.97e-05	6.25e-05	0.5960	-3.27e-01	-0.498000	7.83e-03	5.18e-05
Attenuation phase	23	1.37e-02	2.37e-02	0.3650	-1.58e-01	-0.329000	1.90e-01	6.36e-03
Cytosolic tRNA aminoacylation	24	1.72e-02	2.89e-02	0.3470	-3.15e-01	-0.145000	7.49e-03	2.19e-01
Transcriptional regulation of white adipocyte differentiation	81	6.52e-06	2.35e-05	0.3240	-1.28e-01	-0.297000	4.71e-02	3.70e-06
Signaling by NTRKs	131	5.79e-15	9.33e-14	0.4240	-2.03e-01	-0.372000	5.92e-05	1.75e-13
Protein localization	158	9.55e-03	1.71e-02	0.1370	-1.31e-01	0.037600	4.34e-03	4.15e-01
M Phase	370	1.70e-06	6.98e-06	0.1540	-1.53e-01	0.013800	3.94e-07	6.49e-01
Cytosolic sensors of pathogen-associated DNA	61	3.20e-04	7.96e-04	0.3060	-2.83e-01	-0.117000	1.34e-04	1.15e-01
Signaling by NTRK1 (TRKA)	113	6.78e-13	9.19e-12	0.4220	-2.05e-01	-0.369000	1.72e-04	1.13e-11
Metabolism of lipids	643	1.22e-17	2.42e-16	0.2060	-3.95e-02	-0.202000	8.72e-02	1.67e-18
Metabolism of vitamins and cofactors	171	2.38e-02	3.86e-02	0.1160	7.39e-02	-0.088800	9.53e-02	4.50e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	34	8.73e-03	1.58e-02	0.3150	-2.88e-01	-0.126000	3.64e-03	2.02e-01
Sensory Perception	173	1.97e-02	3.25e-02	0.1180	5.70e-02	-0.104000	1.96e-01	1.84e-02
Disorders of transmembrane transporters	153	2.32e-05	7.26e-05	0.2200	-2.14e-01	-0.053000	5.02e-06	2.58e-01
Signaling by FGFR2	66	1.99e-03	4.06e-03	0.2570	-2.43e-01	-0.082800	6.23e-04	2.45e-01
Negative regulators of DDX58/IFIH1 signaling	35	7.18e-05	2.02e-04	0.4430	-3.83e-01	-0.222000	8.85e-05	2.28e-02
Interferon gamma signaling	78	2.96e-03	5.79e-03	0.2280	-2.20e-01	-0.060100	7.89e-04	3.59e-01
RHO GTPases activate KTN1	11	1.20e-03	2.60e-03	0.6650	-3.84e-01	-0.543000	2.75e-02	1.81e-03
activated TAK1 mediates p38 MAPK activation	18	1.38e-02	2.38e-02	0.4130	-2.01e-01	-0.361000	1.39e-01	8.05e-03
Diseases of signal transduction by growth factor receptors and second messengers	404	1.35e-33	6.38e-32	0.3680	-1.69e-01	-0.327000	5.80e-09	1.06e-29
Transport of small molecules	598	4.33e-09	3.14e-08	0.1470	1.29e-02	-0.146000	5.90e-01	1.01e-09
DNA Double Strand Break Response	52	3.13e-02	4.94e-02	0.2150	-2.09e-01	-0.049900	9.23e-03	5.33e-01
Inositol phosphate metabolism	45	3.42e-03	6.58e-03	0.2990	-1.17e-01	-0.275000	1.75e-01	1.39e-03
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	7.69e-05	2.15e-04	0.4350	-2.18e-01	-0.376000	2.34e-02	9.33e-05
Nucleotide biosynthesis	12	3.67e-03	7.00e-03	0.5810	-4.82e-01	-0.324000	3.83e-03	5.17e-02
Clathrin-mediated endocytosis	135	9.09e-12	1.06e-10	0.3680	-1.69e-01	-0.326000	6.80e-04	5.67e-11
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	51	1.93e-02	3.19e-02	0.2320	-2.23e-01	-0.066100	5.91e-03	4.14e-01
Signaling by FGFR1	46	9.84e-04	2.16e-03	0.3270	-1.40e-01	-0.296000	1.00e-01	5.11e-04
Cargo trafficking to the periciliary membrane	47	3.56e-03	6.84e-03	0.2920	-1.14e-01	-0.268000	1.77e-01	1.45e-03
EPHA-mediated growth cone collapse	15	1.56e-02	2.66e-02	0.4470	-2.29e-01	-0.383000	1.25e-01	1.01e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	6.77e-04	1.55e-03	0.4490	-2.31e-01	-0.385000	4.11e-02	6.70e-04
Fc epsilon receptor (FCERI) signaling	126	1.67e-09	1.31e-08	0.3390	-3.04e-01	-0.150000	3.80e-09	3.58e-03
G alpha (i) signalling events	194	4.58e-03	8.65e-03	0.1340	2.06e-02	-0.133000	6.20e-01	1.45e-03
RAB geranylgeranylation	62	3.75e-05	1.12e-04	0.3430	-1.54e-01	-0.306000	3.58e-02	3.03e-05
Golgi-to-ER retrograde transport	111	4.47e-13	6.18e-12	0.4300	-2.19e-01	-0.370000	6.79e-05	1.60e-11
Signaling by Non-Receptor Tyrosine Kinases	52	1.97e-03	4.02e-03	0.2920	-1.17e-01	-0.267000	1.44e-01	8.56e-04
Signaling by PTK6	52	1.97e-03	4.02e-03	0.2920	-1.17e-01	-0.267000	1.44e-01	8.56e-04
Transcriptional regulation by RUNX3	94	6.02e-07	2.80e-06	0.3300	-2.96e-01	-0.146000	7.02e-07	1.42e-02
Neutrophil degranulation	406	3.72e-09	2.77e-08	0.1820	-3.08e-02	-0.179000	2.86e-01	5.29e-10
NR1H2 and NR1H3-mediated signaling	43	1.61e-03	3.37e-03	0.3270	-1.45e-01	-0.293000	1.00e-01	8.86e-04
Oxidative Stress Induced Senescence	82	2.85e-02	4.53e-02	0.1720	-1.70e-01	-0.022300	7.68e-03	7.26e-01
Processive synthesis on the lagging strand	15	3.65e-03	6.97e-03	0.5200	4.33e-01	0.287000	3.66e-03	5.42e-02
Protein ubiquitination	73	3.11e-08	1.86e-07	0.4130	-3.55e-01	-0.211000	1.56e-07	1.79e-03
Metabolism of steroids	136	7.84e-05	2.18e-04	0.2210	-6.75e-02	-0.210000	1.74e-01	2.26e-05
Chromatin modifying enzymes	222	3.74e-18	7.95e-17	0.3610	-3.16e-01	-0.175000	4.33e-16	7.25e-06
Chromatin organization	222	3.74e-18	7.95e-17	0.3610	-3.16e-01	-0.175000	4.33e-16	7.25e-06
Signaling by Hedgehog	132	7.68e-03	1.40e-02	0.1580	-1.57e-01	-0.015800	1.81e-03	7.54e-01
MAPK family signaling cascades	292	9.16e-14	1.36e-12	0.2710	-1.09e-01	-0.248000	1.32e-03	2.59e-13
Mitochondrial biogenesis	91	6.45e-04	1.49e-03	0.2390	-2.23e-01	-0.084100	2.29e-04	1.65e-01
Leading Strand Synthesis	14	6.05e-03	1.12e-02	0.5130	4.26e-01	0.287000	5.81e-03	6.29e-02
Polymerase switching	14	6.05e-03	1.12e-02	0.5130	4.26e-01	0.287000	5.81e-03	6.29e-02
Transcriptional regulation by RUNX1	184	6.54e-06	2.35e-05	0.2140	-2.03e-01	-0.065200	1.92e-06	1.27e-01
TNF signaling	44	9.71e-03	1.73e-02	0.2740	-2.49e-01	-0.113000	4.21e-03	1.96e-01
Phospholipid metabolism	186	3.53e-12	4.24e-11	0.3190	-1.47e-01	-0.283000	5.25e-04	2.57e-11
MAP kinase activation	62	3.43e-10	3.16e-09	0.5040	-2.83e-01	-0.418000	1.18e-04	1.27e-08
HCMV Late Events	76	3.86e-05	1.14e-04	0.3090	-2.76e-01	-0.141000	3.25e-05	3.39e-02
Unfolded Protein Response (UPR)	89	6.86e-07	3.14e-06	0.3380	-2.97e-01	-0.163000	1.28e-06	7.96e-03
Protein folding	89	8.20e-03	1.49e-02	0.1940	-1.87e-01	-0.052600	2.33e-03	3.91e-01
Interferon Signaling	172	2.09e-09	1.62e-08	0.2890	-2.60e-01	-0.126000	4.12e-09	4.36e-03
Activation of HOX genes during differentiation	81	1.76e-02	2.94e-02	0.1860	-1.80e-01	-0.047000	5.08e-03	4.64e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	81	1.76e-02	2.94e-02	0.1860	-1.80e-01	-0.047000	5.08e-03	4.64e-01
Signaling by the B Cell Receptor (BCR)	106	5.99e-05	1.72e-04	0.2550	-2.34e-01	-0.102000	3.07e-05	6.99e-02
EPHB-mediated forward signaling	34	1.78e-05	5.79e-05	0.4820	-2.69e-01	-0.400000	6.58e-03	5.38e-05
E3 ubiquitin ligases ubiquitinate target proteins	53	3.03e-04	7.59e-04	0.3310	-2.90e-01	-0.160000	2.56e-04	4.44e-02
RAB GEFs exchange GTP for GDP on RABs	88	6.36e-09	4.40e-08	0.3930	-2.06e-01	-0.335000	8.27e-04	5.42e-08
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.36e-06	5.69e-06	0.4770	-3.94e-01	-0.268000	7.65e-06	2.36e-03
Lewis blood group biosynthesis	14	2.65e-02	4.26e-02	0.4330	-2.36e-01	-0.362000	1.26e-01	1.89e-02
Citric acid cycle (TCA cycle)	22	8.12e-05	2.24e-04	0.5570	-4.51e-01	-0.326000	2.48e-04	8.06e-03
Signaling by BMP	23	1.21e-05	4.13e-05	0.5970	-3.55e-01	-0.480000	3.17e-03	6.74e-05
Unwinding of DNA	12	5.50e-05	1.60e-04	0.7700	6.03e-01	0.480000	2.99e-04	4.02e-03
XBP1(S) activates chaperone genes	48	2.04e-06	8.29e-06	0.4440	-2.47e-01	-0.369000	3.04e-03	9.55e-06
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	7.45e-03	1.36e-02	0.3170	-1.55e-01	-0.277000	1.13e-01	4.62e-03
Cell Cycle, Mitotic	512	6.83e-04	1.56e-03	0.0954	-9.02e-02	0.031100	4.71e-04	2.27e-01
Post-translational protein modification	1261	1.50e-52	3.66e-50	0.2660	-1.18e-01	-0.238000	1.51e-12	1.84e-46
G alpha (q) signalling events	152	1.07e-05	3.68e-05	0.2320	-9.22e-02	-0.212000	4.96e-02	6.10e-06
Activation of gene expression by SREBF (SREBP)	42	7.43e-09	5.04e-08	0.5680	-3.37e-01	-0.458000	1.54e-04	2.86e-07
Signaling by Activin	15	7.85e-05	2.18e-04	0.6760	-5.34e-01	-0.414000	3.40e-04	5.44e-03
Spry regulation of FGF signaling	16	3.46e-04	8.50e-04	0.6010	-4.80e-01	-0.361000	8.77e-04	1.24e-02
SARS-CoV Infections	150	2.75e-11	3.05e-10	0.3420	-1.75e-01	-0.294000	2.07e-04	5.04e-10
IRE1alpha activates chaperones	50	3.90e-07	1.87e-06	0.4620	-2.62e-01	-0.381000	1.34e-03	3.19e-06
Neddylation	222	2.81e-09	2.13e-08	0.2520	-2.27e-01	-0.109000	5.04e-09	5.05e-03
Transcriptional Regulation by TP53	356	1.29e-08	8.39e-08	0.1900	-1.80e-01	-0.061900	5.14e-09	4.48e-02
G1/S-Specific Transcription	29	2.57e-03	5.10e-03	0.3850	3.25e-01	0.207000	2.45e-03	5.39e-02
Infectious disease	733	5.37e-25	1.67e-23	0.2360	-2.15e-01	-0.097200	2.82e-23	7.16e-06
Pre-NOTCH Processing in Golgi	18	2.08e-02	3.41e-02	0.3940	-2.14e-01	-0.331000	1.17e-01	1.50e-02
Interleukin-17 signaling	67	1.55e-08	9.85e-08	0.4410	-2.48e-01	-0.364000	4.44e-04	2.46e-07
Interactions of Rev with host cellular proteins	37	3.83e-05	1.14e-04	0.4460	-3.67e-01	-0.253000	1.11e-04	7.64e-03
HCMV Early Events	80	7.37e-07	3.36e-06	0.3570	-3.03e-01	-0.189000	2.84e-06	3.39e-03
Nonhomologous End-Joining (NHEJ)	43	3.41e-03	6.57e-03	0.3080	-2.67e-01	-0.154000	2.45e-03	8.02e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	6.43e-05	1.83e-04	0.3250	-2.79e-01	-0.167000	9.04e-05	1.92e-02
Cell Cycle	636	6.30e-04	1.46e-03	0.0860	-8.01e-02	0.031500	5.57e-04	1.74e-01
p130Cas linkage to MAPK signaling for integrins	12	1.86e-03	3.83e-03	0.6160	-3.77e-01	-0.488000	2.39e-02	3.42e-03
Interleukin-20 family signaling	19	2.74e-02	4.37e-02	0.3700	-2.00e-01	-0.311000	1.32e-01	1.89e-02
Sialic acid metabolism	31	4.34e-03	8.23e-03	0.3560	-1.90e-01	-0.301000	6.68e-02	3.76e-03
SUMOylation of DNA replication proteins	46	8.22e-05	2.26e-04	0.3840	-3.21e-01	-0.212000	1.68e-04	1.28e-02
Transport of Mature mRNA Derived from an Intronless Transcript	42	2.92e-06	1.15e-05	0.4690	-3.81e-01	-0.273000	1.93e-05	2.16e-03
Signal amplification	28	3.29e-04	8.11e-04	0.4550	-2.64e-01	-0.371000	1.55e-02	6.77e-04
Rev-mediated nuclear export of HIV RNA	35	3.50e-05	1.05e-04	0.4610	-3.74e-01	-0.269000	1.27e-04	5.86e-03
RHO GTPases activate PKNs	52	3.07e-02	4.85e-02	0.2190	-1.98e-01	-0.093200	1.36e-02	2.45e-01
COPI-dependent Golgi-to-ER retrograde traffic	78	4.33e-08	2.46e-07	0.3970	-2.24e-01	-0.328000	6.22e-04	5.63e-07
Adaptive Immune System	639	3.12e-25	9.93e-24	0.2540	-1.21e-01	-0.224000	1.80e-07	3.43e-22
SUMOylation of SUMOylation proteins	35	3.03e-06	1.18e-05	0.5130	-4.10e-01	-0.308000	2.63e-05	1.61e-03
Synaptic adhesion-like molecules	21	1.01e-02	1.79e-02	0.3980	-2.26e-01	-0.327000	7.28e-02	9.37e-03
Regulation of PTEN mRNA translation	12	2.08e-04	5.35e-04	0.7160	-4.54e-01	-0.554000	6.49e-03	8.83e-04
Inflammasomes	19	2.84e-02	4.53e-02	0.3680	-3.06e-01	-0.205000	2.11e-02	1.22e-01
Regulation of IFNA signaling	12	2.37e-02	3.85e-02	0.4750	-2.82e-01	-0.382000	9.03e-02	2.18e-02
Deubiquitination	246	2.48e-15	4.04e-14	0.3150	-2.66e-01	-0.169000	5.99e-13	5.06e-06
Immune System	1611	9.35e-47	1.37e-44	0.2240	-1.02e-01	-0.199000	7.38e-12	5.32e-41
MAPK1/MAPK3 signaling	253	3.16e-09	2.38e-08	0.2360	-1.12e-01	-0.208000	2.18e-03	1.12e-08
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	7.22e-04	1.64e-03	0.6910	-4.38e-01	-0.534000	1.18e-02	2.15e-03
DNA strand elongation	32	2.68e-07	1.32e-06	0.5860	4.59e-01	0.365000	7.01e-06	3.58e-04
RAF/MAP kinase cascade	247	4.97e-09	3.52e-08	0.2370	-1.14e-01	-0.207000	2.07e-03	1.91e-08
Assembly and cell surface presentation of NMDA receptors	23	2.31e-02	3.77e-02	0.3440	-1.92e-01	-0.286000	1.11e-01	1.78e-02
Macroautophagy	111	5.73e-06	2.08e-05	0.2800	-1.47e-01	-0.239000	7.51e-03	1.37e-05
Cellular Senescence	152	8.17e-04	1.84e-03	0.1830	-1.66e-01	-0.077000	4.13e-04	1.01e-01
Gene expression (Transcription)	1368	1.52e-39	1.11e-37	0.2220	-1.95e-01	-0.107000	7.29e-34	2.23e-11
Intracellular signaling by second messengers	287	9.44e-19	2.09e-17	0.3250	-1.83e-01	-0.269000	9.73e-08	4.49e-15
Nuclear import of Rev protein	34	7.17e-05	2.02e-04	0.4510	-3.58e-01	-0.275000	3.02e-04	5.53e-03
Synthesis of substrates in N-glycan biosythesis	61	1.86e-03	3.83e-03	0.2730	-1.47e-01	-0.230000	4.69e-02	1.90e-03
RNA Polymerase II Transcription	1234	7.75e-31	3.34e-29	0.2060	-1.80e-01	-0.098400	8.96e-27	5.31e-09
PCNA-Dependent Long Patch Base Excision Repair	21	2.89e-02	4.60e-02	0.3500	2.03e-01	0.285000	1.07e-01	2.40e-02
Regulation of TP53 Degradation	35	1.20e-03	2.60e-03	0.3730	-3.00e-01	-0.222000	2.11e-03	2.32e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	76	1.88e-02	3.11e-02	0.1940	-9.25e-02	-0.170000	1.63e-01	1.02e-02
SUMOylation	170	1.09e-07	5.82e-07	0.2620	-1.42e-01	-0.219000	1.34e-03	7.86e-07
Lagging Strand Synthesis	20	2.01e-03	4.07e-03	0.4750	3.72e-01	0.295000	3.97e-03	2.23e-02
Signaling by FGFR3	38	9.76e-04	2.15e-03	0.3640	-2.16e-01	-0.293000	2.13e-02	1.79e-03
Mitotic Prophase	103	3.55e-06	1.37e-05	0.2970	-2.45e-01	-0.168000	1.71e-05	3.16e-03
RHO GTPase Effectors	254	1.36e-07	7.12e-07	0.2120	-1.07e-01	-0.184000	3.33e-03	4.56e-07
SUMOylation of RNA binding proteins	47	4.50e-04	1.07e-03	0.3450	-2.78e-01	-0.204000	9.64e-04	1.56e-02
Innate Immune System	838	3.33e-22	9.38e-21	0.2090	-1.07e-01	-0.180000	1.39e-07	6.82e-19
Endosomal Sorting Complex Required For Transport (ESCRT)	31	2.96e-02	4.69e-02	0.2870	-2.36e-01	-0.163000	2.31e-02	1.16e-01
Toll Like Receptor 9 (TLR9) Cascade	90	1.36e-09	1.10e-08	0.4060	-2.50e-01	-0.320000	4.21e-05	1.47e-07
Transport of the SLBP Dependant Mature mRNA	36	1.24e-06	5.35e-06	0.5240	-4.04e-01	-0.334000	2.73e-05	5.26e-04
Rab regulation of trafficking	120	4.21e-12	5.02e-11	0.3990	-2.45e-01	-0.315000	3.62e-06	2.54e-09
Developmental Biology	843	2.54e-16	4.43e-15	0.1780	-8.61e-02	-0.155000	2.07e-05	1.55e-14
TNFR1-induced NFkappaB signaling pathway	26	1.58e-02	2.68e-02	0.3400	-2.73e-01	-0.204000	1.61e-02	7.23e-02
ESR-mediated signaling	170	5.47e-14	8.26e-13	0.3620	-2.19e-01	-0.288000	8.17e-07	8.87e-11
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	85	2.08e-08	1.29e-07	0.3890	-2.38e-01	-0.307000	1.43e-04	9.57e-07
Toll-like Receptor Cascades	139	2.05e-08	1.28e-07	0.3040	-1.78e-01	-0.247000	2.86e-04	4.97e-07
Disease	1437	1.81e-29	6.97e-28	0.1870	-9.45e-02	-0.162000	1.73e-09	6.57e-25
Activation of the pre-replicative complex	33	1.74e-03	3.61e-03	0.3740	2.29e-01	0.295000	2.27e-02	3.31e-03
MyD88 cascade initiated on plasma membrane	80	1.67e-09	1.31e-08	0.4290	-2.68e-01	-0.334000	3.29e-05	2.31e-07
Toll Like Receptor 10 (TLR10) Cascade	80	1.67e-09	1.31e-08	0.4290	-2.68e-01	-0.334000	3.29e-05	2.31e-07
Toll Like Receptor 5 (TLR5) Cascade	80	1.67e-09	1.31e-08	0.4290	-2.68e-01	-0.334000	3.29e-05	2.31e-07
EGFR downregulation	29	1.90e-03	3.91e-03	0.3960	-2.46e-01	-0.311000	2.20e-02	3.77e-03
Chaperonin-mediated protein folding	83	8.32e-03	1.51e-02	0.2040	-1.73e-01	-0.109000	6.50e-03	8.62e-02
Signaling by FGFR4	37	4.87e-03	9.16e-03	0.3230	-1.95e-01	-0.258000	4.05e-02	6.61e-03
SUMO E3 ligases SUMOylate target proteins	164	4.62e-07	2.19e-06	0.2540	-1.46e-01	-0.208000	1.23e-03	4.15e-06
SLC transporter disorders	80	2.77e-04	7.01e-04	0.2730	-1.60e-01	-0.221000	1.36e-02	6.27e-04
HCMV Infection	104	5.76e-07	2.69e-06	0.3170	-2.52e-01	-0.192000	8.92e-06	6.93e-04
Autophagy	124	4.03e-08	2.32e-07	0.3160	-1.92e-01	-0.251000	2.18e-04	1.35e-06
Generic Transcription Pathway	1116	2.74e-27	1.00e-25	0.2030	-1.70e-01	-0.111000	6.46e-22	2.99e-10
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	33	2.07e-02	3.41e-02	0.2920	-2.34e-01	-0.175000	2.02e-02	8.17e-02
Thrombin signalling through proteinase activated receptors (PARs)	27	3.65e-03	6.97e-03	0.3890	-2.44e-01	-0.302000	2.82e-02	6.51e-03
Negative regulation of FGFR1 signaling	29	2.96e-03	5.79e-03	0.3820	-2.98e-01	-0.239000	5.55e-03	2.56e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	2.83e-02	4.52e-02	0.4300	-2.74e-01	-0.332000	7.61e-02	3.16e-02
N-glycan antennae elongation in the medial/trans-Golgi	25	8.58e-04	1.93e-03	0.4530	-2.91e-01	-0.347000	1.17e-02	2.65e-03
Antiviral mechanism by IFN-stimulated genes	80	1.52e-09	1.23e-08	0.4300	-3.31e-01	-0.275000	3.17e-07	2.12e-05
Mitochondrial Fatty Acid Beta-Oxidation	34	9.47e-03	1.70e-02	0.3150	1.94e-01	0.249000	5.07e-02	1.19e-02
MyD88-independent TLR4 cascade	93	1.24e-09	1.01e-08	0.4010	-2.54e-01	-0.310000	2.23e-05	2.40e-07
TRIF(TICAM1)-mediated TLR4 signaling	93	1.24e-09	1.01e-08	0.4010	-2.54e-01	-0.310000	2.23e-05	2.40e-07
RHOBTB2 GTPase cycle	23	2.74e-02	4.37e-02	0.3370	-2.64e-01	-0.210000	2.84e-02	8.18e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	28	4.01e-06	1.52e-05	0.5680	-3.74e-01	-0.428000	6.15e-04	8.87e-05
Selective autophagy	58	1.67e-04	4.38e-04	0.3300	-2.59e-01	-0.205000	6.48e-04	6.92e-03
Regulation of HSF1-mediated heat shock response	78	3.68e-08	2.14e-07	0.4000	-3.08e-01	-0.255000	2.54e-06	9.92e-05
Signaling by NOTCH	193	1.05e-04	2.84e-04	0.1860	-1.55e-01	-0.102000	2.01e-04	1.42e-02
tRNA Aminoacylation	42	2.36e-02	3.84e-02	0.2540	-2.04e-01	-0.152000	2.19e-02	8.93e-02
Signaling by WNT	276	1.42e-13	2.01e-12	0.2800	-1.70e-01	-0.223000	1.15e-06	1.82e-10
N-Glycan antennae elongation	14	1.75e-03	3.62e-03	0.5740	-3.79e-01	-0.432000	1.41e-02	5.18e-03
Transport of Ribonucleoproteins into the Host Nucleus	32	2.67e-05	8.19e-05	0.4890	-3.19e-01	-0.371000	1.80e-03	2.79e-04
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.75e-03	3.62e-03	0.2980	-2.35e-01	-0.183000	3.34e-03	2.25e-02
TGF-beta receptor signaling activates SMADs	32	3.78e-05	1.13e-04	0.4810	-3.65e-01	-0.314000	3.52e-04	2.14e-03
Signaling by Nuclear Receptors	236	1.69e-12	2.10e-11	0.2900	-1.78e-01	-0.229000	2.47e-06	1.33e-09
Toll Like Receptor 3 (TLR3) Cascade	89	1.59e-10	1.53e-09	0.4300	-2.77e-01	-0.328000	6.05e-06	8.53e-08
Signaling by TGF-beta Receptor Complex	74	9.30e-13	1.23e-11	0.5220	-3.43e-01	-0.394000	3.29e-07	4.71e-09
Nuclear Envelope Breakdown	53	4.21e-05	1.24e-04	0.3720	-2.37e-01	-0.287000	2.86e-03	3.03e-04
MyD88 dependent cascade initiated on endosome	86	2.40e-08	1.47e-07	0.3860	-2.46e-01	-0.296000	7.74e-05	1.99e-06
Toll Like Receptor 7/8 (TLR7/8) Cascade	86	2.40e-08	1.47e-07	0.3860	-2.46e-01	-0.296000	7.74e-05	1.99e-06
Toll Like Receptor 4 (TLR4) Cascade	121	5.94e-08	3.30e-07	0.3170	-1.98e-01	-0.247000	1.69e-04	2.63e-06
Downregulation of TGF-beta receptor signaling	26	5.37e-05	1.56e-04	0.5250	-3.95e-01	-0.346000	4.95e-04	2.29e-03
TCF dependent signaling in response to WNT	186	3.89e-07	1.87e-06	0.2410	-1.93e-01	-0.144000	5.69e-06	7.01e-04
Beta-catenin independent WNT signaling	138	4.60e-06	1.73e-05	0.2550	-2.03e-01	-0.154000	3.91e-05	1.74e-03
Regulation of TP53 Activity through Acetylation	29	4.05e-04	9.71e-04	0.4430	-3.36e-01	-0.288000	1.72e-03	7.27e-03
Programmed Cell Death	195	1.99e-03	4.06e-03	0.1520	-8.13e-02	-0.129000	5.01e-02	1.94e-03
SUMOylation of transcription cofactors	44	6.32e-04	1.46e-03	0.3490	-2.22e-01	-0.269000	1.08e-02	2.00e-03
Signaling by TGFB family members	98	6.70e-15	1.07e-13	0.4930	-3.24e-01	-0.371000	2.90e-08	2.12e-10
Transport of the SLBP independent Mature mRNA	35	2.53e-06	1.00e-05	0.5180	-3.88e-01	-0.342000	7.04e-05	4.54e-04
ER Quality Control Compartment (ERQC)	21	1.15e-02	2.02e-02	0.3930	-2.99e-01	-0.255000	1.75e-02	4.30e-02
Vpr-mediated nuclear import of PICs	34	4.88e-06	1.82e-05	0.5120	-3.83e-01	-0.339000	1.09e-04	6.25e-04
RHOBTB GTPase Cycle	35	1.72e-04	4.49e-04	0.4250	-2.79e-01	-0.320000	4.28e-03	1.05e-03
Transcriptional activation of mitochondrial biogenesis	53	1.16e-08	7.56e-08	0.5010	-3.33e-01	-0.374000	2.66e-05	2.46e-06
Signaling by FGFR	78	2.76e-03	5.43e-03	0.2340	-1.85e-01	-0.145000	4.82e-03	2.73e-02
Regulation of TP53 Activity	155	9.01e-06	3.16e-05	0.2340	-1.84e-01	-0.144000	7.67e-05	1.90e-03
SUMOylation of ubiquitinylation proteins	39	1.39e-05	4.64e-05	0.4570	-3.42e-01	-0.303000	2.20e-04	1.05e-03
Nuclear Envelope (NE) Reassembly	73	3.68e-03	7.01e-03	0.2360	-1.85e-01	-0.147000	6.33e-03	2.94e-02
Export of Viral Ribonucleoproteins from Nucleus	33	1.23e-04	3.27e-04	0.4460	-2.96e-01	-0.333000	3.22e-03	9.30e-04
Signaling by NODAL	19	5.24e-04	1.23e-03	0.5380	-3.62e-01	-0.398000	6.34e-03	2.66e-03
ISG15 antiviral mechanism	72	1.81e-08	1.14e-07	0.4250	-3.18e-01	-0.282000	3.08e-06	3.53e-05
Antigen processing: Ubiquitination & Proteasome degradation	292	4.00e-17	7.32e-16	0.3080	-2.35e-01	-0.200000	4.88e-12	4.23e-09
NS1 Mediated Effects on Host Pathways	40	2.66e-05	8.17e-05	0.4380	-3.27e-01	-0.292000	3.49e-04	1.41e-03
Deadenylation of mRNA	22	1.59e-07	8.27e-07	0.7200	-4.91e-01	-0.526000	6.62e-05	1.96e-05
ADP signalling through P2Y purinoceptor 1	21	9.19e-03	1.65e-02	0.4030	-2.68e-01	-0.301000	3.36e-02	1.68e-02
Signaling by FGFR in disease	59	5.20e-03	9.77e-03	0.2550	-1.64e-01	-0.195000	2.96e-02	9.51e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	2.40e-06	9.59e-06	0.3170	-2.08e-01	-0.239000	4.84e-04	6.22e-05
Toll Like Receptor 2 (TLR2) Cascade	94	2.40e-06	9.59e-06	0.3170	-2.08e-01	-0.239000	4.84e-04	6.22e-05
Toll Like Receptor TLR1:TLR2 Cascade	94	2.40e-06	9.59e-06	0.3170	-2.08e-01	-0.239000	4.84e-04	6.22e-05
Toll Like Receptor TLR6:TLR2 Cascade	94	2.40e-06	9.59e-06	0.3170	-2.08e-01	-0.239000	4.84e-04	6.22e-05
Nervous system development	522	8.27e-12	9.77e-11	0.1900	-1.19e-01	-0.149000	3.47e-06	5.53e-09
Estrogen-dependent gene expression	107	1.62e-05	5.34e-05	0.2740	-2.07e-01	-0.180000	2.20e-04	1.26e-03
PIP3 activates AKT signaling	251	2.31e-15	3.80e-14	0.3140	-2.09e-01	-0.234000	1.22e-08	1.52e-10
HDR through Homologous Recombination (HRR)	66	1.50e-03	3.17e-03	0.2680	1.77e-01	0.202000	1.31e-02	4.63e-03
Regulation of TP53 Expression and Degradation	36	1.67e-03	3.49e-03	0.3600	-2.66e-01	-0.242000	5.67e-03	1.21e-02
Metabolism	1856	4.20e-04	1.00e-03	0.0570	-5.01e-02	-0.027000	3.24e-04	5.24e-02
HSF1 activation	26	1.46e-02	2.51e-02	0.3440	-2.32e-01	-0.254000	4.08e-02	2.48e-02
Cytokine Signaling in Immune system	596	8.21e-19	1.85e-17	0.2280	-1.72e-01	-0.150000	6.83e-13	3.93e-10
Cellular response to heat stress	94	4.47e-11	4.74e-10	0.4300	-3.14e-01	-0.294000	1.39e-07	8.51e-07
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	2.40e-03	4.78e-03	0.2990	-2.01e-01	-0.222000	1.48e-02	7.25e-03
Association of TriC/CCT with target proteins during biosynthesis	37	1.32e-03	2.82e-03	0.3610	-2.45e-01	-0.265000	9.89e-03	5.21e-03
SUMOylation of DNA damage response and repair proteins	76	2.12e-05	6.70e-05	0.3210	-2.17e-01	-0.237000	1.06e-03	3.53e-04
Apoptosis	169	4.71e-03	8.88e-03	0.1520	-9.73e-02	-0.117000	2.90e-02	8.60e-03
Axon guidance	500	1.60e-09	1.28e-08	0.1730	-1.12e-01	-0.132000	1.62e-05	4.32e-07
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	6.16e-09	4.28e-08	0.5530	-4.00e-01	-0.382000	3.36e-06	9.34e-06
PKMTs methylate histone lysines	45	8.74e-05	2.40e-04	0.3890	-2.84e-01	-0.266000	9.74e-04	2.04e-03
Ovarian tumor domain proteases	37	2.37e-05	7.40e-05	0.4580	-3.15e-01	-0.333000	9.25e-04	4.61e-04
Synthesis of PA	32	1.63e-02	2.77e-02	0.3060	-2.24e-01	-0.208000	2.80e-02	4.16e-02
Metabolism of proteins	1731	1.62e-36	8.49e-35	0.1930	-1.44e-01	-0.128000	1.33e-23	5.62e-19
Signaling by Interleukins	384	1.14e-11	1.30e-10	0.2200	-1.48e-01	-0.163000	6.13e-07	4.15e-08
Glycerophospholipid biosynthesis	110	1.74e-03	3.61e-03	0.2050	-1.38e-01	-0.152000	1.24e-02	5.81e-03
Potential therapeutics for SARS	81	2.35e-07	1.19e-06	0.3710	-2.55e-01	-0.269000	7.11e-05	2.84e-05
Nuclear Events (kinase and transcription factor activation)	60	9.77e-08	5.23e-07	0.4430	-3.20e-01	-0.306000	1.83e-05	4.02e-05
Resolution of D-Loop Structures	33	3.94e-03	7.48e-03	0.3500	2.41e-01	0.253000	1.66e-02	1.18e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	32	1.07e-02	1.90e-02	0.3210	2.21e-01	0.233000	3.05e-02	2.23e-02
Nuclear Pore Complex (NPC) Disassembly	36	3.56e-04	8.73e-04	0.4010	-2.89e-01	-0.277000	2.64e-03	3.99e-03
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.17e-03	2.55e-03	0.5920	-4.24e-01	-0.413000	5.97e-03	7.43e-03
Regulation of PTEN gene transcription	61	1.20e-03	2.60e-03	0.2840	-1.95e-01	-0.206000	8.31e-03	5.48e-03
SUMOylation of chromatin organization proteins	57	6.72e-05	1.91e-04	0.3510	-2.43e-01	-0.252000	1.49e-03	9.77e-04
NEP/NS2 Interacts with the Cellular Export Machinery	32	5.08e-05	1.48e-04	0.4740	-3.31e-01	-0.340000	1.18e-03	8.85e-04
RHO GTPases activate CIT	19	3.06e-02	4.85e-02	0.3650	-2.56e-01	-0.261000	5.38e-02	4.87e-02
Negative regulation of FGFR3 signaling	27	1.92e-02	3.18e-02	0.3270	-2.33e-01	-0.228000	3.58e-02	4.00e-02
Activation of ATR in response to replication stress	37	6.12e-03	1.13e-02	0.3170	2.27e-01	0.221000	1.71e-02	1.97e-02
Class I MHC mediated antigen processing & presentation	352	1.25e-17	2.44e-16	0.2850	-1.99e-01	-0.204000	1.23e-10	4.32e-11
Interactions of Vpr with host cellular proteins	37	6.60e-06	2.37e-05	0.4850	-3.44e-01	-0.341000	2.87e-04	3.33e-04
TBC/RABGAPs	43	6.20e-07	2.86e-06	0.4920	-3.46e-01	-0.350000	8.54e-05	7.21e-05
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.00e-04	2.72e-04	0.4580	-3.25e-01	-0.323000	1.48e-03	1.57e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.00e-04	2.72e-04	0.4580	-3.25e-01	-0.323000	1.48e-03	1.57e-03

---

Detailed Gene set reports

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	87
pMANOVA	2.79e-43
p.adjustMANOVA	3.4e-41
s.dist	0.83
s.KO	-0.422
s.drug	0.715
p.KO	9.35e-12
p.drug	8.26e-31

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EEF1A1	-9758	-7439
EEF2	-6416	-8810
FAU	-8610	13102
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	87
pMANOVA	3.07e-43
p.adjustMANOVA	3.46e-41
s.dist	0.83
s.KO	-0.42
s.drug	0.715
p.KO	1.17e-11
p.drug	7.1e-31

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
DNAJC3	-2895	-7549
FAU	-8610	13102
GRSF1	-11152	-7843
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	99
pMANOVA	1.26e-44
p.adjustMANOVA	1.68e-42
s.dist	0.789
s.KO	-0.444
s.drug	0.652
p.KO	2.03e-14
p.drug	3.21e-29

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
FAU	-8610	13102
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	91
pMANOVA	2.19e-41
p.adjustMANOVA	1.89e-39
s.dist	0.794
s.KO	-0.402
s.drug	0.684
p.KO	3.27e-11
p.drug	1.32e-29

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
APEH	9298	-8571
ETF1	-5515	-9496
FAU	-8610	13102
GSPT1	-11018	-10261
GSPT2	-5509	-6727
N6AMT1	7099	10581
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
TRMT112	-5741	13057
UBA52	-6807	11639

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	92
pMANOVA	1.82e-41
p.adjustMANOVA	1.67e-39
s.dist	0.79
s.KO	-0.412
s.drug	0.674
p.KO	8.16e-12
p.drug	4.97e-29

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EEF1A1	-9758	-7439
EEF1A1P5	-2416	-8237
EEF1A2	11418	-3449
EEF1B2	-9424	8464
EEF1D	-2336	11037
EEF1G	-7846	-5785
EEF2	-6416	-8810
FAU	-8610	13102
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

metric	value
setSize	13
pMANOVA	1.43e-06
p.adjustMANOVA	5.93e-06
s.dist	0.799
s.KO	0.358
s.drug	-0.714
p.KO	0.0255
p.drug	8.23e-06

Top 20 genes

Gene	KO	drug
AGRN	12518	-11205
SDC4	12322	-10633
EXT2	11023	-9224
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
EXT1	10114	-6275
GPC5	7673	-3135
GPC1	1951	-7922

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
EXT1	10114	-6275
EXT2	11023	-9224
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HSPG2	-9046	-9768
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633

---

---

Defective EXT2 causes exostoses 2

Defective EXT2 causes exostoses 2

metric	value
setSize	13
pMANOVA	1.43e-06
p.adjustMANOVA	5.93e-06
s.dist	0.799
s.KO	0.358
s.drug	-0.714
p.KO	0.0255
p.drug	8.23e-06

Top 20 genes

Gene	KO	drug
AGRN	12518	-11205
SDC4	12322	-10633
EXT2	11023	-9224
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
EXT1	10114	-6275
GPC5	7673	-3135
GPC1	1951	-7922

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
EXT1	10114	-6275
EXT2	11023	-9224
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HSPG2	-9046	-9768
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633

---

---

Laminin interactions

Laminin interactions

metric	value
setSize	23
pMANOVA	1.23e-11
p.adjustMANOVA	1.39e-10
s.dist	0.827
s.KO	0.269
s.drug	-0.782
p.KO	0.0258
p.drug	8.23e-11

Top 20 genes

Gene	KO	drug
LAMC1	12854	-11227
LAMB2	12607	-10832
LAMA5	12583	-10447
ITGA1	12258	-10552
LAMA1	12802	-10091
ITGA3	12831	-9596
NID1	9752	-11078
ITGB4	12465	-8452
ITGA7	12807	-7517
ITGA2	8062	-11213
LAMB3	7018	-11255
LAMC2	10786	-6533
COL18A1	10348	-6371
LAMC3	11660	-2369
ITGAV	144	-11011

Click HERE to show all gene set members

All member genes

	KO	drug
COL18A1	10348	-6371
HSPG2	-9046	-9768
ITGA1	12258	-10552
ITGA2	8062	-11213
ITGA3	12831	-9596
ITGA6	-7384	-11184
ITGA7	12807	-7517
ITGAV	144	-11011
ITGB1	-3655	-11215
ITGB4	12465	-8452
LAMA1	12802	-10091
LAMA2	-8729	-4164
LAMA3	-11238	4464
LAMA4	-7403	-10348
LAMA5	12583	-10447
LAMB1	-9087	-10329
LAMB2	12607	-10832
LAMB3	7018	-11255
LAMC1	12854	-11227
LAMC2	10786	-6533
LAMC3	11660	-2369
NID1	9752	-11078
NID2	-11453	-7028

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	99
pMANOVA	6.6e-41
p.adjustMANOVA	5.37e-39
s.dist	0.755
s.KO	-0.423
s.drug	0.625
p.KO	3.36e-13
p.drug	5.07e-27

Top 20 genes

Gene	KO	drug
ASNS	-10878	12349
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382

Click HERE to show all gene set members

All member genes

	KO	drug
ASNS	-10878	12349
ATF2	-8942	-9289
ATF3	-4081	-4353
ATF4	-6768	11948
CEBPB	-7116	12656
CEBPG	-9940	6581
DDIT3	-9395	10987
EIF2AK4	10865	-7766
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
FAU	-8610	13102
GCN1	10665	-8257
IMPACT	-1732	-8127
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
TRIB3	-3221	-5552
UBA52	-6807	11639

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	93
pMANOVA	6.86e-38
p.adjustMANOVA	4.02e-36
s.dist	0.749
s.KO	-0.424
s.drug	0.617
p.KO	1.55e-12
p.drug	6.83e-25

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EIF4G1	9159	-10287
ETF1	-5515	-9496
FAU	-8610	13102
GSPT1	-11018	-10261
GSPT2	-5509	-6727
NCBP1	-7784	-5234
NCBP2	-6378	-6281
PABPC1	-7033	-10406
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639
UPF1	-10419	-10092

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	91
pMANOVA	1.38e-38
p.adjustMANOVA	8.77e-37
s.dist	0.768
s.KO	-0.355
s.drug	0.681
p.KO	4.6e-09
p.drug	2.66e-29

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EEFSEC	11184	-3492
FAU	-8610	13102
PSTK	5756	9314
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SARS1	10748	-9421
SECISBP2	11207	-6517
SEPHS2	8103	-351
SEPSECS	-6443	-5096
UBA52	-6807	11639

---

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

metric	value
setSize	50
pMANOVA	7.28e-20
p.adjustMANOVA	1.67e-18
s.dist	0.731
s.KO	-0.501
s.drug	0.532
p.KO	8.83e-10
p.drug	7.23e-11

Top 20 genes

Gene	KO	drug
RPS17	-10534	11631
RPS13	-9450	12652
RPS25	-9371	12690
RPS18	-9122	12984
RPS6	-9225	12405
RPS15A	-8754	12989
FAU	-8610	13102
RPS4X	-8542	12239
RPS11	-7725	12935
EIF3C	-8843	11244
RPS19	-7633	12888
EIF3M	-10718	9044
EIF3I	-7897	12235
RPS15	-7430	12908
EIF3E	-9070	10545
RPS3	-7756	12135
RPS12	-7872	11600
RPS2	-10222	8916
RPS9	-8815	10189
RPS10	-8384	10665

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
FAU	-8610	13102
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576

---

---

Syndecan interactions

Syndecan interactions

metric	value
setSize	19
pMANOVA	5.07e-10
p.adjustMANOVA	4.45e-09
s.dist	0.844
s.KO	0.216
s.drug	-0.816
p.KO	0.104
p.drug	7.21e-10

Top 20 genes

Gene	KO	drug
ITGB3	12688	-11286
SDC4	12322	-10633
PRKCA	12366	-10396
ITGB5	12503	-10104
ITGB4	12465	-8452
THBS1	12626	-7518
ITGA2	8062	-11213
ACTN1	8122	-10816
SDC1	12230	-7104
SDC3	12401	-6760
ITGAV	144	-11011

Click HERE to show all gene set members

All member genes

	KO	drug
ACTN1	8122	-10816
CASK	-5732	-8641
FGF2	-5091	-5204
ITGA2	8062	-11213
ITGA6	-7384	-11184
ITGAV	144	-11011
ITGB1	-3655	-11215
ITGB3	12688	-11286
ITGB4	12465	-8452
ITGB5	12503	-10104
PRKCA	12366	-10396
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
TGFB1	-3526	-8816
THBS1	12626	-7518
TNC	-10537	-10838
TRAPPC4	-10355	-4660

---

---

Mucopolysaccharidoses

Mucopolysaccharidoses

metric	value
setSize	11
pMANOVA	1.36e-05
p.adjustMANOVA	4.58e-05
s.dist	0.799
s.KO	0.756
s.drug	-0.258
p.KO	1.41e-05
p.drug	0.138

Top 20 genes

Gene	KO	drug
GNS	11099	-11125
GLB1	10162	-9240
ARSB	12086	-7494
IDS	8178	-10132
GALNS	11751	-6370
NAGLU	12163	-5299
HGSNAT	6442	-3959

Click HERE to show all gene set members

All member genes

	KO	drug
ARSB	12086	-7494
GALNS	11751	-6370
GLB1	10162	-9240
GNS	11099	-11125
GUSB	9430	8910
HGSNAT	6442	-3959
HYAL1	4794	556
IDS	8178	-10132
IDUA	11538	11620
NAGLU	12163	-5299
SGSH	11466	8231

---

---

Defective B4GALT7 causes EDS, progeroid type

Defective B4GALT7 causes EDS, progeroid type

metric	value
setSize	18
pMANOVA	1.1e-07
p.adjustMANOVA	5.83e-07
s.dist	0.739
s.KO	0.371
s.drug	-0.639
p.KO	0.00644
p.drug	2.71e-06

Top 20 genes

Gene	KO	drug
CSPG4	12459	-11273
AGRN	12518	-11205
SDC4	12322	-10633
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
B4GALT7	10562	-4980
BCAN	12079	-4013
GPC5	7673	-3135
BGN	11953	-1313
GPC1	1951	-7922
NCAN	3533	-1773
CSPG5	545	-3163

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
B4GALT7	10562	-4980
BCAN	12079	-4013
BGN	11953	-1313
CSPG4	12459	-11273
CSPG5	545	-3163
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HSPG2	-9046	-9768
NCAN	3533	-1773
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
VCAN	-1861	-11263

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	109
pMANOVA	3.24e-39
p.adjustMANOVA	2.26e-37
s.dist	0.702
s.KO	-0.466
s.drug	0.525
p.KO	3.94e-17
p.drug	2.32e-21

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4G1	9159	-10287
EIF4H	-10967	-8512
FAU	-8610	13102
PABPC1	-7033	-10406
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	110
pMANOVA	3.32e-38
p.adjustMANOVA	2.03e-36
s.dist	0.69
s.KO	-0.442
s.drug	0.53
p.KO	1.11e-15
p.drug	6.6e-22

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4G1	9159	-10287
EIF4H	-10967	-8512
EIF5	10203	-9440
EIF5B	10163	12775
FAU	-8610	13102
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

Defective B3GAT3 causes JDSSDHD

Defective B3GAT3 causes JDSSDHD

metric	value
setSize	18
pMANOVA	9.01e-07
p.adjustMANOVA	3.96e-06
s.dist	0.687
s.KO	0.376
s.drug	-0.575
p.KO	0.00569
p.drug	2.43e-05

Top 20 genes

Gene	KO	drug
CSPG4	12459	-11273
AGRN	12518	-11205
SDC4	12322	-10633
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
BCAN	12079	-4013
GPC5	7673	-3135
BGN	11953	-1313
GPC1	1951	-7922
NCAN	3533	-1773
CSPG5	545	-3163

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
B3GAT3	11784	9103
BCAN	12079	-4013
BGN	11953	-1313
CSPG4	12459	-11273
CSPG5	545	-3163
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HSPG2	-9046	-9768
NCAN	3533	-1773
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
VCAN	-1861	-11263

---

---

Other semaphorin interactions

Other semaphorin interactions

metric	value
setSize	15
pMANOVA	8.68e-06
p.adjustMANOVA	3.06e-05
s.dist	0.689
s.KO	0.359
s.drug	-0.588
p.KO	0.0159
p.drug	7.98e-05

Top 20 genes

Gene	KO	drug
PLXNA1	12834	-10985
ITGA1	12258	-10552
PLXNA4	11726	-9845
SEMA7A	9143	-11223
SEMA6A	12824	-7654
PLXNB3	11348	-6567
PLXND1	11557	-4291
PLXNC1	7782	-4731

Click HERE to show all gene set members

All member genes

	KO	drug
CD72	-627	3306
ITGA1	12258	-10552
ITGB1	-3655	-11215
PLXNA1	12834	-10985
PLXNA2	-1563	-6909
PLXNA4	11726	-9845
PLXNB3	11348	-6567
PLXNC1	7782	-4731
PLXND1	11557	-4291
SEMA4A	-31	5409
SEMA4D	9903	32
SEMA5A	-11537	-10912
SEMA6A	12824	-7654
SEMA6D	-5924	-7539
SEMA7A	9143	-11223

---

---

Defective B3GALT6 causes EDSP2 and SEMDJL1

Defective B3GALT6 causes EDSP2 and SEMDJL1

metric	value
setSize	18
pMANOVA	1.31e-06
p.adjustMANOVA	5.63e-06
s.dist	0.677
s.KO	0.375
s.drug	-0.564
p.KO	0.00592
p.drug	3.38e-05

Top 20 genes

Gene	KO	drug
CSPG4	12459	-11273
AGRN	12518	-11205
SDC4	12322	-10633
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
BCAN	12079	-4013
GPC5	7673	-3135
BGN	11953	-1313
GPC1	1951	-7922
NCAN	3533	-1773
CSPG5	545	-3163

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
B3GALT6	11393	11355
BCAN	12079	-4013
BGN	11953	-1313
CSPG4	12459	-11273
CSPG5	545	-3163
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HSPG2	-9046	-9768
NCAN	3533	-1773
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
VCAN	-1861	-11263

---

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

metric	value
setSize	117
pMANOVA	2.43e-37
p.adjustMANOVA	1.32e-35
s.dist	0.662
s.KO	-0.423
s.drug	0.509
p.KO	2.56e-15
p.drug	1.77e-21

Top 20 genes

Gene	KO	drug
EIF4EBP1	-11425	12142
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2B1	11179	11041
EIF2B2	-2856	-6814
EIF2B3	3812	8509
EIF2B4	-8202	8563
EIF2B5	8652	-2008
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4EBP1	-11425	12142
EIF4G1	9159	-10287
EIF4H	-10967	-8512
EIF5	10203	-9440
EIF5B	10163	12775
FAU	-8610	13102
PABPC1	-7033	-10406
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

metric	value
setSize	117
pMANOVA	2.43e-37
p.adjustMANOVA	1.32e-35
s.dist	0.662
s.KO	-0.423
s.drug	0.509
p.KO	2.56e-15
p.drug	1.77e-21

Top 20 genes

Gene	KO	drug
EIF4EBP1	-11425	12142
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2B1	11179	11041
EIF2B2	-2856	-6814
EIF2B3	3812	8509
EIF2B4	-8202	8563
EIF2B5	8652	-2008
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4EBP1	-11425	12142
EIF4G1	9159	-10287
EIF4H	-10967	-8512
EIF5	10203	-9440
EIF5B	10163	12775
FAU	-8610	13102
PABPC1	-7033	-10406
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
UBA52	-6807	11639

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	110
pMANOVA	3.9e-35
p.adjustMANOVA	1.97e-33
s.dist	0.662
s.KO	-0.393
s.drug	0.533
p.KO	9.93e-13
p.drug	4.19e-22

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
DDOST	9438	-6642
FAU	-8610	13102
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPN1	-4194	1205
RPN2	11923	-9366
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SEC11A	7466	10882
SEC11C	-9228	9516
SEC61A1	-5502	-10602
SEC61A2	-122	-3639
SEC61B	-8269	12482
SEC61G	-7012	-6414
SPCS1	1876	9024
SPCS2	-9826	1441
SPCS3	-4819	-8123
SRP14	11867	12615
SRP19	-7488	10214
SRP54	-10408	-9159
SRP68	-8580	-10245
SRP72	-11292	-11041
SRP9	-5683	-6445
SRPRA	-11264	-9507
SRPRB	-4441	7574
SSR1	-6980	-9998
SSR2	-4823	-3645
SSR3	2021	-10353
SSR4	4605	12772
TRAM1	-8764	-11121
UBA52	-6807	11639

---

---

Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels

metric	value
setSize	12
pMANOVA	0.000199
p.adjustMANOVA	0.000513
s.dist	0.656
s.KO	0.423
s.drug	-0.502
p.KO	0.0112
p.drug	0.00259

Top 20 genes

Gene	KO	drug
ATP2A3	12011	-9206
ATP2B4	7929	-11266
SLC8A2	11131	-7612
ATP2A2	7536	-11089
SLC8A3	12029	-6726
CALM1	11329	-6948
ATP2B1	6952	-10931
SLC8A1	10101	-6530
ATP2B2	1355	-2448

Click HERE to show all gene set members

All member genes

	KO	drug
ATP2A1	-7073	10801
ATP2A2	7536	-11089
ATP2A3	12011	-9206
ATP2B1	6952	-10931
ATP2B2	1355	-2448
ATP2B3	5288	7244
ATP2B4	7929	-11266
CALM1	11329	-6948
SLC8A1	10101	-6530
SLC8A2	11131	-7612
SLC8A3	12029	-6726
SRI	-8466	-7625

---

---

Non-integrin membrane-ECM interactions

Non-integrin membrane-ECM interactions

metric	value
setSize	41
pMANOVA	1.27e-16
p.adjustMANOVA	2.25e-15
s.dist	0.751
s.KO	0.2
s.drug	-0.724
p.KO	0.0268
p.drug	1e-15

Top 20 genes

Gene	KO	drug
LAMC1	12854	-11227
ITGB3	12688	-11286
PDGFB	12741	-11178
AGRN	12518	-11205
LAMB2	12607	-10832
LAMA5	12583	-10447
SDC4	12322	-10633
LAMA1	12802	-10091
PRKCA	12366	-10396
ITGB5	12503	-10104
ITGB4	12465	-8452
DDR1	12660	-8206
THBS1	12626	-7518
PDGFA	12623	-7408
ITGA2	8062	-11213
ACTN1	8122	-10816
SDC1	12230	-7104
SDC3	12401	-6760
LAMB3	7018	-11255
LAMC2	10786	-6533

Click HERE to show all gene set members

All member genes

	KO	drug
ACTN1	8122	-10816
AGRN	12518	-11205
CASK	-5732	-8641
DAG1	6148	-8573
DDR1	12660	-8206
DDR2	-9960	-7915
DMD	-237	910
FGF2	-5091	-5204
HSPG2	-9046	-9768
ITGA2	8062	-11213
ITGA6	-7384	-11184
ITGAV	144	-11011
ITGB1	-3655	-11215
ITGB3	12688	-11286
ITGB4	12465	-8452
ITGB5	12503	-10104
LAMA1	12802	-10091
LAMA2	-8729	-4164
LAMA3	-11238	4464
LAMA4	-7403	-10348
LAMA5	12583	-10447
LAMB1	-9087	-10329
LAMB2	12607	-10832
LAMB3	7018	-11255
LAMC1	12854	-11227
LAMC2	10786	-6533
LAMC3	11660	-2369
NRXN1	-7510	141
NTN4	-8804	-7703
PDGFA	12623	-7408
PDGFB	12741	-11178
PRKCA	12366	-10396
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
TGFB1	-3526	-8816
THBS1	12626	-7518
TNC	-10537	-10838
TRAPPC4	-10355	-4660
TTR	-212	1928

---

---

MET activates PTK2 signaling

MET activates PTK2 signaling

metric	value
setSize	18
pMANOVA	6.8e-08
p.adjustMANOVA	3.72e-07
s.dist	0.765
s.KO	0.155
s.drug	-0.749
p.KO	0.256
p.drug	3.71e-08

Top 20 genes

Gene	KO	drug
LAMC1	12854	-11227
LAMB2	12607	-10832
LAMA5	12583	-10447
LAMA1	12802	-10091
ITGA3	12831	-9596
MET	10796	-11047
ITGA2	8062	-11213
LAMB3	7018	-11255
LAMC2	10786	-6533
LAMC3	11660	-2369

Click HERE to show all gene set members

All member genes

	KO	drug
HGF	-5157	-4177
ITGA2	8062	-11213
ITGA3	12831	-9596
ITGB1	-3655	-11215
LAMA1	12802	-10091
LAMA2	-8729	-4164
LAMA3	-11238	4464
LAMA4	-7403	-10348
LAMA5	12583	-10447
LAMB1	-9087	-10329
LAMB2	12607	-10832
LAMB3	7018	-11255
LAMC1	12854	-11227
LAMC2	10786	-6533
LAMC3	11660	-2369
MET	10796	-11047
PTK2	-9167	-10148
SRC	-11388	-7284

---

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

metric	value
setSize	58
pMANOVA	5.49e-18
p.adjustMANOVA	1.13e-16
s.dist	0.646
s.KO	-0.521
s.drug	0.382
p.KO	6.74e-12
p.drug	4.78e-07

Top 20 genes

Gene	KO	drug
EIF4EBP1	-11425	12142
RPS17	-10534	11631
RPS13	-9450	12652
RPS25	-9371	12690
RPS18	-9122	12984
RPS6	-9225	12405
RPS15A	-8754	12989
FAU	-8610	13102
RPS4X	-8542	12239
RPS11	-7725	12935
EIF3C	-8843	11244
RPS19	-7633	12888
EIF3M	-10718	9044
EIF3I	-7897	12235
RPS15	-7430	12908
EIF3E	-9070	10545
RPS3	-7756	12135
RPS12	-7872	11600
RPS2	-10222	8916
RPS9	-8815	10189

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4EBP1	-11425	12142
EIF4G1	9159	-10287
EIF4H	-10967	-8512
FAU	-8610	13102
PABPC1	-7033	-10406
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576

---

---

Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis

metric	value
setSize	13
pMANOVA	0.000173
p.adjustMANOVA	0.00045
s.dist	0.635
s.KO	-0.437
s.drug	0.462
p.KO	0.00639
p.drug	0.00396

Top 20 genes

Gene	KO	drug
SLC25A37	-9868	12952
GLRX5	-9519	11726
HSCB	-10466	7562
FDX1	-8625	8318
ISCU	-6298	10132
FDX2	-5678	10706
LYRM4	-3448	10228
SLC25A28	-2674	12676

Click HERE to show all gene set members

All member genes

	KO	drug
FDX1	-8625	8318
FDX2	-5678	10706
FDXR	6797	-10
FXN	3001	6244
GLRX5	-9519	11726
HSCB	-10466	7562
ISCA1	-7587	-4971
ISCA2	2253	4958
ISCU	-6298	10132
LYRM4	-3448	10228
NFS1	-8587	-4816
SLC25A28	-2674	12676
SLC25A37	-9868	12952

---

---

Translation initiation complex formation

Translation initiation complex formation

metric	value
setSize	57
pMANOVA	4.76e-17
p.adjustMANOVA	8.61e-16
s.dist	0.634
s.KO	-0.512
s.drug	0.373
p.KO	2.15e-11
p.drug	1.12e-06

Top 20 genes

Gene	KO	drug
RPS17	-10534	11631
RPS13	-9450	12652
RPS25	-9371	12690
RPS18	-9122	12984
RPS6	-9225	12405
RPS15A	-8754	12989
FAU	-8610	13102
RPS4X	-8542	12239
RPS11	-7725	12935
EIF3C	-8843	11244
RPS19	-7633	12888
EIF3M	-10718	9044
EIF3I	-7897	12235
RPS15	-7430	12908
EIF3E	-9070	10545
RPS3	-7756	12135
RPS12	-7872	11600
RPS2	-10222	8916
RPS9	-8815	10189
RPS10	-8384	10665

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4G1	9159	-10287
EIF4H	-10967	-8512
FAU	-8610	13102
PABPC1	-7033	-10406
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576

---

---

The activation of arylsulfatases

The activation of arylsulfatases

metric	value
setSize	10
pMANOVA	0.00191
p.adjustMANOVA	0.00391
s.dist	0.616
s.KO	0.417
s.drug	-0.454
p.KO	0.0225
p.drug	0.0129

Top 20 genes

Gene	KO	drug
SUMF2	11753	-9338
ARSB	12086	-7494
ARSD	9745	-6384
SUMF1	11852	-4769
ARSG	12508	-4208
STS	6761	-3002

Click HERE to show all gene set members

All member genes

	KO	drug
ARSA	11743	9589
ARSB	12086	-7494
ARSD	9745	-6384
ARSG	12508	-4208
ARSI	-7529	-4701
ARSJ	-8413	-8593
ARSK	-2824	-7149
STS	6761	-3002
SUMF1	11852	-4769
SUMF2	11753	-9338

---

---

HS-GAG degradation

HS-GAG degradation

metric	value
setSize	19
pMANOVA	7.84e-06
p.adjustMANOVA	2.77e-05
s.dist	0.612
s.KO	0.424
s.drug	-0.441
p.KO	0.00136
p.drug	0.000862

Top 20 genes

Gene	KO	drug
AGRN	12518	-11205
SDC4	12322	-10633
GPC4	11190	-8942
GLB1	10162	-9240
SDC1	12230	-7104
SDC3	12401	-6760
IDS	8178	-10132
NAGLU	12163	-5299
GPC5	7673	-3135
GPC1	1951	-7922

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
GLB1	10162	-9240
GLB1L	10787	1974
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
GUSB	9430	8910
HPSE	-6814	-4898
HSPG2	-9046	-9768
IDS	8178	-10132
IDUA	11538	11620
NAGLU	12163	-5299
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
SGSH	11466	8231

---

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

metric	value
setSize	57
pMANOVA	4.22e-16
p.adjustMANOVA	7.19e-15
s.dist	0.615
s.KO	-0.488
s.drug	0.374
p.KO	1.87e-10
p.drug	1.03e-06

Top 20 genes

Gene	KO	drug
RPS17	-10534	11631
RPS13	-9450	12652
RPS25	-9371	12690
RPS18	-9122	12984
RPS6	-9225	12405
RPS15A	-8754	12989
FAU	-8610	13102
RPS4X	-8542	12239
RPS11	-7725	12935
EIF3C	-8843	11244
RPS19	-7633	12888
EIF3M	-10718	9044
EIF3I	-7897	12235
RPS15	-7430	12908
EIF3E	-9070	10545
RPS3	-7756	12135
RPS12	-7872	11600
RPS2	-10222	8916
RPS9	-8815	10189
RPS10	-8384	10665

Click HERE to show all gene set members

All member genes

	KO	drug
EIF1AX	-5479	11112
EIF2S1	-8950	-8774
EIF2S2	-10653	-6089
EIF2S3	-10174	-5022
EIF3A	-5233	-9195
EIF3B	-4779	-8277
EIF3C	-8843	11244
EIF3D	-10400	-7621
EIF3E	-9070	10545
EIF3F	-1343	-5879
EIF3G	-7655	4326
EIF3H	-8110	-1879
EIF3I	-7897	12235
EIF3J	-4825	-4367
EIF3K	-2668	9951
EIF3L	-9160	-8016
EIF3M	-10718	9044
EIF4A1	-8156	-2754
EIF4A2	-9799	-8479
EIF4B	-9005	-10529
EIF4E	-10282	-8119
EIF4G1	9159	-10287
EIF4H	-10967	-8512
EIF5	10203	-9440
FAU	-8610	13102
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576

---

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

metric	value
setSize	180
pMANOVA	4.38e-48
p.adjustMANOVA	7.14e-46
s.dist	0.607
s.KO	-0.442
s.drug	0.415
p.KO	1.15e-24
p.drug	6.33e-22

Top 20 genes

Gene	KO	drug
SNU13	-10311	12575
RPP21	-10144	12682
RPL22L1	-10448	12221
RRP1	-10564	11767
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
UTP11	-10533	11453
RPL26L1	-9387	12770
RPS13	-9450	12652
NOP58	-9719	12285
RPS25	-9371	12690
PELP1	-10416	11398
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989

Click HERE to show all gene set members

All member genes

	KO	drug
BMS1	2178	-7536
BOP1	-7790	11804
BYSL	-9303	-4305
C1D	4815	-6610
CSNK1D	10532	-5548
CSNK1E	-10445	-9281
DCAF13	-10197	3606
DDX21	-9821	-11141
DDX47	-3040	-3704
DDX49	-6948	11408
DDX52	-4956	-6639
DHX37	-6857	-5150
DIS3	-7066	-10210
EBNA1BP2	-5730	8621
EMG1	-8533	12199
ERI1	-6981	-7986
EXOSC1	5616	12257
EXOSC10	11323	10109
EXOSC2	-6345	11400
EXOSC3	-9626	11413
EXOSC4	-5748	12031
EXOSC5	-8463	12469
EXOSC6	-4792	6631
EXOSC7	-9145	12400
EXOSC8	-5608	12846
EXOSC9	2510	12417
FAU	-8610	13102
FBL	-9012	11058
FCF1	709	-9413
FTSJ3	6717	-6330
GNL3	-10056	-3684
HEATR1	-2296	-10015
IMP3	8515	12268
IMP4	-11049	7633
ISG20L2	9239	-8076
KRR1	-1464	-4631
LAS1L	7432	11693
LTV1	-7819	11102
MPHOSPH10	-6190	11406
MPHOSPH6	-2428	9099
MTREX	-8233	-5923
NCL	-9791	-342
NIP7	-7922	9186
NOB1	-9953	-8397
NOC4L	-6715	11954
NOL11	-3226	-8080
NOL12	5520	12622
NOL6	-9823	2445
NOL9	-6385	-511
NOP14	-10166	-3847
NOP56	-7158	12073
NOP58	-9719	12285
PDCD11	-8464	-9477
PELP1	-10416	11398
PES1	-9830	-6872
PNO1	-3440	-3672
PWP2	-2846	-152
RBM28	-10901	3636
RCL1	-11359	8957
RIOK1	-10244	-3480
RIOK2	-6415	4119
RIOK3	-9445	-11119
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPP14	-7031	-2565
RPP21	-10144	12682
RPP25	12002	11609
RPP30	4656	11993
RPP38	-6789	3778
RPP40	-7844	9292
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
RRP1	-10564	11767
RRP36	-6050	-2045
RRP7A	-2282	10997
RRP9	-7176	12125
SENP3	-6212	-9010
SNORD3A	-5504	7763
SNU13	-10311	12575
TBL3	-9717	9564
TEX10	-10686	-7186
TSR1	-11196	-7332
UBA52	-6807	11639
UTP11	-10533	11453
UTP14A	6133	11385
UTP14C	4183	769
UTP15	-2850	-3508
UTP18	-9890	-9637
UTP20	7490	-8121
UTP25	-2108	-9255
UTP3	-4017	10489
UTP4	-6489	3608
UTP6	-9002	-4625
WDR12	-10594	3479
WDR18	-808	11293
WDR3	-7914	-8658
WDR36	2115	-8307
WDR43	-8618	-5190
WDR46	-9852	176
WDR75	-11340	9185
XRN2	-8638	-11123

---

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

metric	value
setSize	190
pMANOVA	1.23e-50
p.adjustMANOVA	2.57e-48
s.dist	0.606
s.KO	-0.452
s.drug	0.404
p.KO	4.72e-27
p.drug	6.93e-22

Top 20 genes

Gene	KO	drug
NOP2	-10527	12781
SNU13	-10311	12575
RPP21	-10144	12682
RPL22L1	-10448	12221
RRP1	-10564	11767
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
UTP11	-10533	11453
RPL26L1	-9387	12770
RPS13	-9450	12652
NOP58	-9719	12285
RPS25	-9371	12690
PELP1	-10416	11398
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405

Click HERE to show all gene set members

All member genes

	KO	drug
BMS1	2178	-7536
BOP1	-7790	11804
BYSL	-9303	-4305
C1D	4815	-6610
CSNK1D	10532	-5548
CSNK1E	-10445	-9281
DCAF13	-10197	3606
DDX21	-9821	-11141
DDX47	-3040	-3704
DDX49	-6948	11408
DDX52	-4956	-6639
DHX37	-6857	-5150
DIMT1	-9289	-6845
DIS3	-7066	-10210
DKC1	-9026	-6327
EBNA1BP2	-5730	8621
EMG1	-8533	12199
ERI1	-6981	-7986
EXOSC1	5616	12257
EXOSC10	11323	10109
EXOSC2	-6345	11400
EXOSC3	-9626	11413
EXOSC4	-5748	12031
EXOSC5	-8463	12469
EXOSC6	-4792	6631
EXOSC7	-9145	12400
EXOSC8	-5608	12846
EXOSC9	2510	12417
FAU	-8610	13102
FBL	-9012	11058
FCF1	709	-9413
FTSJ3	6717	-6330
GAR1	-8958	8023
GNL3	-10056	-3684
HEATR1	-2296	-10015
IMP3	8515	12268
IMP4	-11049	7633
ISG20L2	9239	-8076
KRR1	-1464	-4631
LAS1L	7432	11693
LTV1	-7819	11102
MPHOSPH10	-6190	11406
MPHOSPH6	-2428	9099
MTREX	-8233	-5923
NAT10	-9415	792
NCL	-9791	-342
NHP2	-218	11370
NIP7	-7922	9186
NOB1	-9953	-8397
NOC4L	-6715	11954
NOL11	-3226	-8080
NOL12	5520	12622
NOL6	-9823	2445
NOL9	-6385	-511
NOP10	2766	11209
NOP14	-10166	-3847
NOP2	-10527	12781
NOP56	-7158	12073
NOP58	-9719	12285
PDCD11	-8464	-9477
PELP1	-10416	11398
PES1	-9830	-6872
PNO1	-3440	-3672
PWP2	-2846	-152
RBM28	-10901	3636
RCL1	-11359	8957
RIOK1	-10244	-3480
RIOK2	-6415	4119
RIOK3	-9445	-11119
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPP14	-7031	-2565
RPP21	-10144	12682
RPP25	12002	11609
RPP30	4656	11993
RPP38	-6789	3778
RPP40	-7844	9292
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
RRP1	-10564	11767
RRP36	-6050	-2045
RRP7A	-2282	10997
RRP9	-7176	12125
SENP3	-6212	-9010
SNORD3A	-5504	7763
SNU13	-10311	12575
TBL3	-9717	9564
TEX10	-10686	-7186
THUMPD1	-10328	-6819
TRMT112	-5741	13057
TSR1	-11196	-7332
TSR3	-8931	-3980
UBA52	-6807	11639
UTP11	-10533	11453
UTP14A	6133	11385
UTP14C	4183	769
UTP15	-2850	-3508
UTP18	-9890	-9637
UTP20	7490	-8121
UTP25	-2108	-9255
UTP3	-4017	10489
UTP4	-6489	3608
UTP6	-9002	-4625
WDR12	-10594	3479
WDR18	-808	11293
WDR3	-7914	-8658
WDR36	2115	-8307
WDR43	-8618	-5190
WDR46	-9852	176
WDR75	-11340	9185
XRN2	-8638	-11123

---

---

Selenoamino acid metabolism

Selenoamino acid metabolism

metric	value
setSize	115
pMANOVA	5.95e-32
p.adjustMANOVA	2.64e-30
s.dist	0.618
s.KO	-0.336
s.drug	0.519
p.KO	4.63e-10
p.drug	6.31e-22

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
AHCY	1345	629
AIMP1	-9006	1838
AIMP2	1872	-2032
CBS	10907	11159
CTH	-3063	-3718
DARS1	-10008	4484
EEF1E1	-10204	1085
EEFSEC	11184	-3492
EPRS1	1368	-10895
FAU	-8610	13102
GNMT	-1375	5139
GSR	-11433	-4996
HNMT	-1649	3699
IARS1	-2182	-9570
INMT	9444	-4952
KARS1	-10243	9778
LARS1	-7999	-5859
MARS1	-1476	10979
MAT1A	-6091	2828
NNMT	12760	12864
PAPSS1	-10307	-3927
PAPSS2	6847	-10771
PSTK	5756	9314
QARS1	10134	-6688
RARS1	-9720	-7252
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SARS1	10748	-9421
SCLY	-9481	10671
SECISBP2	11207	-6517
SEPHS2	8103	-351
SEPSECS	-6443	-5096
TXNRD1	-10964	-9955
UBA52	-6807	11639

---

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

metric	value
setSize	113
pMANOVA	2.07e-30
p.adjustMANOVA	8.41e-29
s.dist	0.606
s.KO	-0.392
s.drug	0.462
p.KO	5.64e-13
p.drug	1.93e-17

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
CASC3	3621	-10268
DCP1A	-8837	-10280
EIF4A3	-628	-6343
EIF4G1	9159	-10287
ETF1	-5515	-9496
FAU	-8610	13102
GSPT1	-11018	-10261
GSPT2	-5509	-6727
MAGOH	-5607	12947
MAGOHB	-7769	12200
NCBP1	-7784	-5234
NCBP2	-6378	-6281
PABPC1	-7033	-10406
PNRC2	2116	6441
PPP2CA	-3124	-7225
PPP2R1A	-9193	-4828
PPP2R2A	-11248	-10666
RBM8A	8447	9246
RNPS1	-10981	-5614
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SMG1	-8987	-10553
SMG5	10836	-9825
SMG6	-7165	-6549
SMG7	9137	-8660
SMG8	9515	-8783
SMG9	-11415	-3130
UBA52	-6807	11639
UPF1	-10419	-10092
UPF2	6857	-7169
UPF3A	-8410	11718
UPF3B	-3041	12685

---

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

metric	value
setSize	113
pMANOVA	2.07e-30
p.adjustMANOVA	8.41e-29
s.dist	0.606
s.KO	-0.392
s.drug	0.462
p.KO	5.64e-13
p.drug	1.93e-17

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382
RPL35	-8027	13097

Click HERE to show all gene set members

All member genes

	KO	drug
CASC3	3621	-10268
DCP1A	-8837	-10280
EIF4A3	-628	-6343
EIF4G1	9159	-10287
ETF1	-5515	-9496
FAU	-8610	13102
GSPT1	-11018	-10261
GSPT2	-5509	-6727
MAGOH	-5607	12947
MAGOHB	-7769	12200
NCBP1	-7784	-5234
NCBP2	-6378	-6281
PABPC1	-7033	-10406
PNRC2	2116	6441
PPP2CA	-3124	-7225
PPP2R1A	-9193	-4828
PPP2R2A	-11248	-10666
RBM8A	8447	9246
RNPS1	-10981	-5614
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SMG1	-8987	-10553
SMG5	10836	-9825
SMG6	-7165	-6549
SMG7	9137	-8660
SMG8	9515	-8783
SMG9	-11415	-3130
UBA52	-6807	11639
UPF1	-10419	-10092
UPF2	6857	-7169
UPF3A	-8410	11718
UPF3B	-3041	12685

---

---

Complex I biogenesis

Complex I biogenesis

metric	value
setSize	57
pMANOVA	8.21e-22
p.adjustMANOVA	2.23e-20
s.dist	0.74
s.KO	-0.123
s.drug	0.729
p.KO	0.109
p.drug	1.49e-21

Top 20 genes

Gene	KO	drug
NDUFA6	-10640	12901
NDUFB10	-9687	12582
NDUFA8	-8774	12900
NDUFS3	-8653	12725
NDUFB9	-8544	12805
NDUFS8	-7989	12773
NDUFB6	-8238	12165
NDUFAB1	-10558	8746
NDUFV2	-6865	13148
NDUFC1	-7186	12437
NDUFAF4	-8760	9608
NDUFS5	-6394	13145
NDUFV3	-6779	12304
NDUFB11	-7090	11583
NDUFA1	-6222	13127
TMEM126B	-8036	9815
NDUFS6	-6327	12108
NDUFA5	-6593	11094
NDUFAF2	-5167	12574
ECSIT	-6333	10115

Click HERE to show all gene set members

All member genes

	KO	drug
ACAD9	12457	11377
COA1	11438	12298
ECSIT	-6333	10115
MT-ND1	5209	13177
MT-ND2	-1457	13183
MT-ND3	6571	13181
MT-ND4	566	13174
MT-ND5	4289	13012
MT-ND6	4676	13045
NDUFA1	-6222	13127
NDUFA10	-7241	-4286
NDUFA11	9807	12851
NDUFA12	6720	13049
NDUFA13	-4424	12971
NDUFA2	5937	13125
NDUFA3	-4508	13084
NDUFA5	-6593	11094
NDUFA6	-10640	12901
NDUFA7	8872	13143
NDUFA8	-8774	12900
NDUFA9	2605	10360
NDUFAB1	-10558	8746
NDUFAF1	2883	9463
NDUFAF2	-5167	12574
NDUFAF3	10175	13112
NDUFAF4	-8760	9608
NDUFAF5	-3460	9719
NDUFAF6	-5625	10508
NDUFAF7	6751	8883
NDUFB1	8092	13163
NDUFB10	-9687	12582
NDUFB11	-7090	11583
NDUFB2	11367	12511
NDUFB3	1661	12046
NDUFB4	8888	13008
NDUFB5	-3244	-5075
NDUFB6	-8238	12165
NDUFB7	-4205	12444
NDUFB8	8367	13039
NDUFB9	-8544	12805
NDUFC1	-7186	12437
NDUFC2	-5184	11409
NDUFS1	-9609	-7041
NDUFS2	3967	-10068
NDUFS3	-8653	12725
NDUFS4	6388	3949
NDUFS5	-6394	13145
NDUFS6	-6327	12108
NDUFS7	5531	12411
NDUFS8	-7989	12773
NDUFV1	-5404	8980
NDUFV2	-6865	13148
NDUFV3	-6779	12304
NUBPL	8039	-8010
TIMMDC1	9211	-3329
TMEM126B	-8036	9815
TMEM186	-8187	5086

---

---

Biotin transport and metabolism

Biotin transport and metabolism

metric	value
setSize	11
pMANOVA	0.000811
p.adjustMANOVA	0.00183
s.dist	0.631
s.KO	0.561
s.drug	-0.29
p.KO	0.00128
p.drug	0.0961

Top 20 genes

Gene	KO	drug
ACACA	11587	-9231
BTD	11562	-8185
PCCA	11484	-7458
MCCC1	12225	-6790
PC	10642	-7758
PCCB	2928	-5796
HLCS	1981	-7850
MCCC2	8284	-1797

Click HERE to show all gene set members

All member genes

	KO	drug
ACACA	11587	-9231
ACACB	10941	6062
BTD	11562	-8185
HLCS	1981	-7850
MCCC1	12225	-6790
MCCC2	8284	-1797
PC	10642	-7758
PCCA	11484	-7458
PCCB	2928	-5796
PDZD11	10212	12640
SLC5A6	-9022	7606

---

---

rRNA processing

rRNA processing

metric	value
setSize	214
pMANOVA	9.34e-54
p.adjustMANOVA	2.74e-51
s.dist	0.589
s.KO	-0.397
s.drug	0.435
p.KO	1.09e-23
p.drug	4.38e-28

Top 20 genes

Gene	KO	drug
NOP2	-10527	12781
SNU13	-10311	12575
RPP21	-10144	12682
RPL22L1	-10448	12221
RRP1	-10564	11767
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
UTP11	-10533	11453
RPL26L1	-9387	12770
RPS13	-9450	12652
NOP58	-9719	12285
RPS25	-9371	12690
PELP1	-10416	11398
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405

Click HERE to show all gene set members

All member genes

	KO	drug
BMS1	2178	-7536
BOP1	-7790	11804
BYSL	-9303	-4305
C1D	4815	-6610
CSNK1D	10532	-5548
CSNK1E	-10445	-9281
DCAF13	-10197	3606
DDX21	-9821	-11141
DDX47	-3040	-3704
DDX49	-6948	11408
DDX52	-4956	-6639
DHX37	-6857	-5150
DIMT1	-9289	-6845
DIS3	-7066	-10210
DKC1	-9026	-6327
EBNA1BP2	-5730	8621
ELAC2	-9745	-1209
EMG1	-8533	12199
ERI1	-6981	-7986
EXOSC1	5616	12257
EXOSC10	11323	10109
EXOSC2	-6345	11400
EXOSC3	-9626	11413
EXOSC4	-5748	12031
EXOSC5	-8463	12469
EXOSC6	-4792	6631
EXOSC7	-9145	12400
EXOSC8	-5608	12846
EXOSC9	2510	12417
FAU	-8610	13102
FBL	-9012	11058
FCF1	709	-9413
FTSJ3	6717	-6330
GAR1	-8958	8023
GNL3	-10056	-3684
HEATR1	-2296	-10015
HSD17B10	2620	11931
IMP3	8515	12268
IMP4	-11049	7633
ISG20L2	9239	-8076
KRR1	-1464	-4631
LAS1L	7432	11693
LTV1	-7819	11102
MPHOSPH10	-6190	11406
MPHOSPH6	-2428	9099
MRM1	6997	6882
MRM2	9539	10866
MRM3	-8705	6922
MT-ATP6	8420	13018
MT-ATP8	9404	12604
MT-CO1	9067	13178
MT-CO2	8603	13180
MT-CO3	8245	13176
MT-CYB	5991	13184
MT-ND1	5209	13177
MT-ND2	-1457	13183
MT-ND3	6571	13181
MT-ND4	566	13174
MT-ND4L	2132	13172
MT-ND5	4289	13012
MT-RNR1	-5225	13169
MT-RNR2	-1383	13168
MTERF4	-10210	9791
MTREX	-8233	-5923
NAT10	-9415	792
NCL	-9791	-342
NHP2	-218	11370
NIP7	-7922	9186
NOB1	-9953	-8397
NOC4L	-6715	11954
NOL11	-3226	-8080
NOL12	5520	12622
NOL6	-9823	2445
NOL9	-6385	-511
NOP10	2766	11209
NOP14	-10166	-3847
NOP2	-10527	12781
NOP56	-7158	12073
NOP58	-9719	12285
NSUN4	-8664	-9020
PDCD11	-8464	-9477
PELP1	-10416	11398
PES1	-9830	-6872
PNO1	-3440	-3672
PRORP	-2649	-8367
PWP2	-2846	-152
RBM28	-10901	3636
RCL1	-11359	8957
RIOK1	-10244	-3480
RIOK2	-6415	4119
RIOK3	-9445	-11119
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPP14	-7031	-2565
RPP21	-10144	12682
RPP25	12002	11609
RPP30	4656	11993
RPP38	-6789	3778
RPP40	-7844	9292
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
RRP1	-10564	11767
RRP36	-6050	-2045
RRP7A	-2282	10997
RRP9	-7176	12125
SENP3	-6212	-9010
SNORD3A	-5504	7763
SNU13	-10311	12575
TBL3	-9717	9564
TEX10	-10686	-7186
TFB1M	-11120	4823
THUMPD1	-10328	-6819
TRMT10C	-106	3998
TRMT112	-5741	13057
TSR1	-11196	-7332
TSR3	-8931	-3980
UBA52	-6807	11639
UTP11	-10533	11453
UTP14A	6133	11385
UTP14C	4183	769
UTP15	-2850	-3508
UTP18	-9890	-9637
UTP20	7490	-8121
UTP25	-2108	-9255
UTP3	-4017	10489
UTP4	-6489	3608
UTP6	-9002	-4625
WDR12	-10594	3479
WDR18	-808	11293
WDR3	-7914	-8658
WDR36	2115	-8307
WDR43	-8618	-5190
WDR46	-9852	176
WDR75	-11340	9185
XRN2	-8638	-11123

---

---

ATF4 activates genes in response to endoplasmic reticulum stress

ATF4 activates genes in response to endoplasmic reticulum stress

metric	value
setSize	26
pMANOVA	4.79e-07
p.adjustMANOVA	2.26e-06
s.dist	0.583
s.KO	-0.453
s.drug	0.367
p.KO	6.33e-05
p.drug	0.0012

Top 20 genes

Gene	KO	drug
ASNS	-10878	12349
EXOSC7	-9145	12400
EXOSC3	-9626	11413
EXOSC5	-8463	12469
DDIT3	-9395	10987
CEBPB	-7116	12656
ATF4	-6768	11948
KHSRP	-8858	8459
EXOSC2	-6345	11400
EXOSC8	-5608	12846
EXOSC4	-5748	12031
CEBPG	-9940	6581
NFYB	-5919	7739
NFYC	-3340	12311
EXOSC6	-4792	6631

Click HERE to show all gene set members

All member genes

	KO	drug
ASNS	-10878	12349
ATF3	-4081	-4353
ATF4	-6768	11948
ATF6	8977	-10990
CEBPB	-7116	12656
CEBPG	-9940	6581
CXCL8	-4457	-2346
DCP2	-7297	-9802
DDIT3	-9395	10987
DIS3	-7066	-10210
EXOSC1	5616	12257
EXOSC2	-6345	11400
EXOSC3	-9626	11413
EXOSC4	-5748	12031
EXOSC5	-8463	12469
EXOSC6	-4792	6631
EXOSC7	-9145	12400
EXOSC8	-5608	12846
EXOSC9	2510	12417
HERPUD1	-261	-7658
IGFBP1	12833	11045
KHSRP	-8858	8459
NFYA	-10786	-9962
NFYB	-5919	7739
NFYC	-3340	12311
PARN	-10553	-1376

---

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

metric	value
setSize	11
pMANOVA	0.00138
p.adjustMANOVA	0.00294
s.dist	0.607
s.KO	-0.543
s.drug	0.273
p.KO	0.00183
p.drug	0.118

Top 20 genes

Gene	KO	drug
SNRPD3	-5633	11696
SNRPB	-4839	12483
SNRPF	-4377	13130
SNRPE	-4775	10726
SNRPG	-3856	13126
LSM10	-2802	12334
SLBP	-10989	534

Click HERE to show all gene set members

All member genes

	KO	drug
LSM10	-2802	12334
LSM11	-6043	-9210
NCBP1	-7784	-5234
NCBP2	-6378	-6281
SLBP	-10989	534
SNRPB	-4839	12483
SNRPD3	-5633	11696
SNRPE	-4775	10726
SNRPF	-4377	13130
SNRPG	-3856	13126
ZNF473	-8128	-6210

---

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

metric	value
setSize	10
pMANOVA	0.00365
p.adjustMANOVA	0.00697
s.dist	0.586
s.KO	-0.502
s.drug	0.303
p.KO	0.00602
p.drug	0.0969

Top 20 genes

Gene	KO	drug
SNRPD3	-5633	11696
SNRPB	-4839	12483
SNRPF	-4377	13130
SNRPE	-4775	10726
SNRPG	-3856	13126
LSM10	-2802	12334

Click HERE to show all gene set members

All member genes

	KO	drug
LSM10	-2802	12334
LSM11	-6043	-9210
NCBP1	-7784	-5234
NCBP2	-6378	-6281
SNRPB	-4839	12483
SNRPD3	-5633	11696
SNRPE	-4775	10726
SNRPF	-4377	13130
SNRPG	-3856	13126
ZNF473	-8128	-6210

---

---

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs

metric	value
setSize	166
pMANOVA	3.5e-39
p.adjustMANOVA	2.33e-37
s.dist	0.57
s.KO	-0.356
s.drug	0.445
p.KO	2.19e-15
p.drug	4.05e-23

Top 20 genes

Gene	KO	drug
SEM1	-9978	13108
RPL22L1	-10448	12221
ELOB	-9703	13020
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RBX1	-9316	12919
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
PSMA4	-9907	11447
FAU	-8610	13102

Click HERE to show all gene set members

All member genes

	KO	drug
CASC3	3621	-10268
COL4A5	12376	8368
CUL2	-2032	-10093
DAG1	6148	-8573
EIF4A3	-628	-6343
EIF4G1	9159	-10287
ELOB	-9703	13020
ELOC	-7394	12764
ETF1	-5515	-9496
FAU	-8610	13102
GSPT1	-11018	-10261
GSPT2	-5509	-6727
HOXA2	8898	12312
ISL1	-4207	3822
LDB1	4147	748
LHX2	10308	-302
LHX4	11564	-5603
LHX9	9237	-4741
MAGOH	-5607	12947
MAGOHB	-7769	12200
MSI1	9573	10261
NCBP1	-7784	-5234
NCBP2	-6378	-6281
PABPC1	-7033	-10406
PSMA1	-9646	10578
PSMA2	-4002	-4430
PSMA3	-5668	12561
PSMA4	-9907	11447
PSMA5	5538	826
PSMA6	-3328	8997
PSMA7	-10164	-7607
PSMB1	-6139	12480
PSMB10	9537	11663
PSMB2	-3364	8976
PSMB3	7905	13078
PSMB4	-1370	12998
PSMB5	-6937	-2970
PSMB6	-6537	10901
PSMB7	-8656	12462
PSMB8	-9783	11153
PSMB9	-9810	10733
PSMC1	-3547	-3814
PSMC2	-9185	11068
PSMC3	-1273	12327
PSMC4	-7156	12714
PSMC5	7024	12041
PSMC6	-7069	697
PSMD1	-9192	-10441
PSMD10	-6869	1286
PSMD11	7720	-8518
PSMD12	813	8775
PSMD13	-5300	12140
PSMD14	-10615	8461
PSMD2	-6801	-10378
PSMD3	-8058	-4798
PSMD4	743	11756
PSMD5	-9642	-8039
PSMD6	-7577	12228
PSMD7	-6198	-6043
PSMD8	-9103	-6526
PSMD9	-7638	-3346
PSME1	-8654	11878
PSME2	-4231	12869
PSME3	11811	-7813
PSME4	-10581	-10843
PSMF1	-7549	-4369
RBM8A	8447	9246
RBX1	-9316	12919
RNPS1	-10981	-5614
ROBO1	-4716	-10678
ROBO2	-6358	1760
ROBO3	-7871	12150
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SEM1	-9978	13108
SLIT1	12338	-6263
SLIT2	-11365	-9218
UBA52	-6807	11639
UBB	-5602	12024
UBC	-10397	7017
UPF2	6857	-7169
UPF3A	-8410	11718
UPF3B	-3041	12685
USP33	1911	-8690
ZSWIM8	10701	-5986

---

---

CREB1 phosphorylation through the activation of Adenylate Cyclase

CREB1 phosphorylation through the activation of Adenylate Cyclase

metric	value
setSize	10
pMANOVA	0.00171
p.adjustMANOVA	0.00356
s.dist	0.632
s.KO	0.195
s.drug	-0.602
p.KO	0.286
p.drug	0.000985

Top 20 genes

Gene	KO	drug
ADCY1	11934	-11008
PRKAR1A	8600	-10630
PRKACB	8849	-9614
CALM1	11329	-6948
PRKAR1B	8608	-4934

Click HERE to show all gene set members

All member genes

	KO	drug
ADCY1	11934	-11008
CALM1	11329	-6948
CREB1	-4739	-8655
PRKACA	8250	9679
PRKACB	8849	-9614
PRKAR1A	8600	-10630
PRKAR1B	8608	-4934
PRKAR2A	-5980	-10943
PRKAR2B	-9276	-5166
PRKX	-7017	-5888

---

---

A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis

metric	value
setSize	24
pMANOVA	3.1e-06
p.adjustMANOVA	1.21e-05
s.dist	0.567
s.KO	0.325
s.drug	-0.465
p.KO	0.00589
p.drug	7.89e-05

Top 20 genes

Gene	KO	drug
CSPG4	12459	-11273
AGRN	12518	-11205
SDC4	12322	-10633
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
XYLT2	10574	-7316
B4GALT7	10562	-4980
BCAN	12079	-4013
GPC5	7673	-3135
BGN	11953	-1313
GPC1	1951	-7922
NCAN	3533	-1773
CSPG5	545	-3163

Click HERE to show all gene set members

All member genes

	KO	drug
AGRN	12518	-11205
B3GALT6	11393	11355
B3GAT1	-914	2011
B3GAT2	-4097	5251
B3GAT3	11784	9103
B4GALT7	10562	-4980
BCAN	12079	-4013
BGN	11953	-1313
CSPG4	12459	-11273
CSPG5	545	-3163
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HSPG2	-9046	-9768
NCAN	3533	-1773
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
VCAN	-1861	-11263
XYLT1	-11081	-10705
XYLT2	10574	-7316

---

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

metric	value
setSize	134
pMANOVA	3.21e-30
p.adjustMANOVA	1.27e-28
s.dist	0.555
s.KO	-0.386
s.drug	0.398
p.KO	1.09e-14
p.drug	1.59e-15

Top 20 genes

Gene	KO	drug
RPL22L1	-10448	12221
RPL9	-9659	12806
RPS17	-10534	11631
RPL34	-9357	12996
RPL12	-9329	12992
RPL26L1	-9387	12770
RPS13	-9450	12652
RPS25	-9371	12690
RPL37A	-9347	12675
RPS18	-9122	12984
RPL17	-8989	12909
RPL31	-8781	13131
RPS6	-9225	12405
RPS15A	-8754	12989
RPL36	-8818	12868
FAU	-8610	13102
POLR2F	-8900	12621
RPL26	-8797	12658
RPLP2	-8225	12999
RPL11	-8529	12382

Click HERE to show all gene set members

All member genes

	KO	drug
AAAS	-4744	12385
DNAJC3	-2895	-7549
FAU	-8610	13102
GRSF1	-11152	-7843
GTF2F1	-7239	-7788
GTF2F2	-7180	9519
HSP90AA1	11397	-7534
IPO5	-10440	-10308
NDC1	-5800	-9199
NUP107	10317	11210
NUP133	6251	-8590
NUP153	-8447	-10433
NUP155	1534	-10720
NUP160	-10172	-9854
NUP188	-11151	-5029
NUP205	12369	-7848
NUP210	12856	-5260
NUP214	-6331	-6303
NUP35	-10251	8114
NUP37	3092	10118
NUP42	8137	9137
NUP43	-7490	9639
NUP50	-10234	-3947
NUP54	-10563	-8348
NUP58	-7370	-10307
NUP62	-5900	-6034
NUP85	7849	10502
NUP88	-10968	2131
NUP93	-6918	-6255
NUP98	-10847	-10135
PARP1	11937	-9418
POLR2A	-11346	-10737
POLR2B	-9710	-9575
POLR2C	-9451	-4938
POLR2D	-9238	4530
POLR2E	-4690	-3689
POLR2F	-8900	12621
POLR2G	-5631	9765
POLR2H	7259	12667
POLR2I	-5731	12659
POLR2J	-6932	12928
POLR2K	8115	12316
POLR2L	12166	11532
POM121	-8878	-9749
POM121C	-9406	-9089
RAE1	-7356	-5016
RANBP2	-5941	-10334
RPL10	-3821	1598
RPL10A	-9707	-8212
RPL11	-8529	12382
RPL12	-9329	12992
RPL13	-3469	12598
RPL13A	-6854	6955
RPL14	-6386	13137
RPL15	-786	12153
RPL17	-8989	12909
RPL18	-6672	12800
RPL18A	-6976	11926
RPL19	3924	12911
RPL21	-6322	5141
RPL22	-5554	9520
RPL22L1	-10448	12221
RPL23	5769	12922
RPL23A	11361	-5257
RPL24	-4591	12995
RPL26	-8797	12658
RPL26L1	-9387	12770
RPL27	6735	11625
RPL27A	-7818	13051
RPL28	-5809	12962
RPL29	-4515	12915
RPL3	-6827	-4536
RPL30	-3907	11096
RPL31	-8781	13131
RPL32	-5028	12983
RPL34	-9357	12996
RPL35	-8027	13097
RPL35A	-1449	12789
RPL36	-8818	12868
RPL36A	-4480	13010
RPL36AL	-8216	12702
RPL37	-4624	13134
RPL37A	-9347	12675
RPL38	1558	13140
RPL39	-6168	11962
RPL39L	-6608	-6269
RPL3L	-510	7904
RPL4	11351	12558
RPL41	-4616	-6075
RPL5	4679	12075
RPL6	-6903	12730
RPL7	-3327	-8789
RPL7A	-6163	11708
RPL8	-7572	10323
RPL9	-9659	12806
RPLP0	-1504	-7331
RPLP1	9026	12731
RPLP2	-8225	12999
RPS10	-8384	10665
RPS11	-7725	12935
RPS12	-7872	11600
RPS13	-9450	12652
RPS14	-1180	12428
RPS15	-7430	12908
RPS15A	-8754	12989
RPS16	-3844	12941
RPS17	-10534	11631
RPS18	-9122	12984
RPS19	-7633	12888
RPS2	-10222	8916
RPS20	-4961	13095
RPS21	-3001	13022
RPS23	6940	11907
RPS24	2369	13034
RPS25	-9371	12690
RPS26	-2615	13114
RPS27	651	11270
RPS27A	5357	6464
RPS27L	7330	12750
RPS28	2716	12485
RPS29	-652	9078
RPS3	-7756	12135
RPS3A	-9170	5257
RPS4X	-8542	12239
RPS5	-6283	-7965
RPS6	-9225	12405
RPS7	5142	12976
RPS8	-5812	12745
RPS9	-8815	10189
RPSA	292	11576
SEC13	-9702	-8646
SEH1L	-9333	-5653
TPR	8761	-5835
UBA52	-6807	11639

---

---

Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis

metric	value
setSize	19
pMANOVA	7e-05
p.adjustMANOVA	0.000198
s.dist	0.553
s.KO	0.35
s.drug	-0.428
p.KO	0.00818
p.drug	0.00125

Top 20 genes

Gene	KO	drug
CHST15	12906	-11169
CSPG4	12459	-11273
CHST11	12103	-10187
CHSY3	10102	-9769
BCAN	12079	-4013
CHSY1	3107	-10988
BGN	11953	-1313
CHST9	11110	-1231
NCAN	3533	-1773
CSPG5	545	-3163

Click HERE to show all gene set members

All member genes

	KO	drug
BCAN	12079	-4013
BGN	11953	-1313
CHPF	-11347	-6066
CHPF2	12137	9414
CHST11	12103	-10187
CHST12	11011	10555
CHST13	11177	9777
CHST15	12906	-11169
CHST3	-2862	-10133
CHST7	-2403	-5448
CHST9	11110	-1231
CHSY1	3107	-10988
CHSY3	10102	-9769
CSGALNACT1	-750	-2738
CSGALNACT2	-10808	-10564
CSPG4	12459	-11273
CSPG5	545	-3163
NCAN	3533	-1773
VCAN	-1861	-11263

---

---

PKA activation

PKA activation

metric	value
setSize	16
pMANOVA	2.75e-05
p.adjustMANOVA	8.39e-05
s.dist	0.646
s.KO	0.145
s.drug	-0.63
p.KO	0.317
p.drug	1.29e-05

Top 20 genes

Gene	KO	drug
ADCY6	12249	-10841
ADCY1	11934	-11008
NBEA	10299	-10694
PRKAR1A	8600	-10630
PRKACB	8849	-9614
CALM1	11329	-6948
ADCY5	11160	-6292
PRKAR1B	8608	-4934
ADCY4	2183	-585

Click HERE to show all gene set members

All member genes

	KO	drug
ADCY1	11934	-11008
ADCY2	-11203	-2904
ADCY3	-9214	-7503
ADCY4	2183	-585
ADCY5	11160	-6292
ADCY6	12249	-10841
ADCY7	-11317	-10422
ADCY9	-7412	-9235
CALM1	11329	-6948
NBEA	10299	-10694
PRKACA	8250	9679
PRKACB	8849	-9614
PRKAR1A	8600	-10630
PRKAR1B	8608	-4934
PRKAR2A	-5980	-10943
PRKAR2B	-9276	-5166

---

---

Diseases associated with glycosaminoglycan metabolism

Diseases associated with glycosaminoglycan metabolism

metric	value
setSize	35
pMANOVA	2.97e-08
p.adjustMANOVA	1.79e-07
s.dist	0.551
s.KO	0.273
s.drug	-0.479
p.KO	0.00521
p.drug	9.35e-07

Top 20 genes

Gene	KO	drug
CSPG4	12459	-11273
AGRN	12518	-11205
SDC4	12322	-10633
EXT2	11023	-9224
GPC4	11190	-8942
SDC1	12230	-7104
SDC3	12401	-6760
PAPSS2	6847	-10771
EXT1	10114	-6275
B4GALT7	10562	-4980
BCAN	12079	-4013
CHSY1	3107	-10988
GPC5	7673	-3135
BGN	11953	-1313
GPC1	1951	-7922
NCAN	3533	-1773
HEXB	1770	-1985
CSPG5	545	-3163

Click HERE to show all gene set members

All member genes

	KO	drug
ACAN	-11431	-5454
AGRN	12518	-11205
B3GALT6	11393	11355
B3GAT3	11784	9103
B4GALT1	-11375	-10725
B4GALT7	10562	-4980
BCAN	12079	-4013
BGN	11953	-1313
CHST14	12268	10719
CHST3	-2862	-10133
CHST6	-4221	-9474
CHSY1	3107	-10988
CSPG4	12459	-11273
CSPG5	545	-3163
EXT1	10114	-6275
EXT2	11023	-9224
GPC1	1951	-7922
GPC2	-3913	-3279
GPC4	11190	-8942
GPC5	7673	-3135
GPC6	-6095	-11229
HEXA	12426	6143
HEXB	1770	-1985
HSPG2	-9046	-9768
NCAN	3533	-1773
OMD	2559	1901
PAPSS2	6847	-10771
PRELP	4474	2215
SDC1	12230	-7104
SDC2	-6754	-5737
SDC3	12401	-6760
SDC4	12322	-10633
SLC26A2	-4295	-10449
ST3GAL3	-7104	-4100
VCAN	-1861	-11263

---

---

Respiratory electron transport

Respiratory electron transport

metric	value
setSize	103
pMANOVA	4.7e-27
p.adjustMANOVA	1.64e-25
s.dist	0.61
s.KO	-0.16
s.drug	0.589
p.KO	0.0049
p.drug	4.56e-25

Top 20 genes

Gene	KO	drug
NDUFA6	-10640	12901
NDUFB10	-9687	12582
COX6B1	-9124	13132
UQCR10	-9028	12920
NDUFA8	-8774	12900
NDUFS3	-8653	12725
NDUFB9	-8544	12805
UQCRH	-8039	12733
NDUFS8	-7989	12773
COX20	-9184	10961
NDUFB6	-8238	12165
COX7B	-7400	13161
TRAP1	-11197	8602
SCO2	-9739	9526
NDUFAB1	-10558	8746
COX8A	-7227	12756
NDUFV2	-6865	13148
NDUFC1	-7186	12437
COX5B	-6531	13149
NDUFAF4	-8760	9608

Click HERE to show all gene set members

All member genes

	KO	drug
ACAD9	12457	11377
COA1	11438	12298
COQ10A	2060	8793
COQ10B	-11071	1561
COX11	3872	-3998
COX14	-5296	7054
COX16	-4741	10348
COX18	-7574	-2747
COX19	5255	5188
COX20	-9184	10961
COX4I1	-1716	13016
COX5A	8620	10682
COX5B	-6531	13149
COX6A1	-1616	13101
COX6B1	-9124	13132
COX6C	5468	12965
COX7A2L	-5446	-8229
COX7B	-7400	13161
COX7C	9483	12599
COX8A	-7227	12756
CYC1	-8796	9550
CYCS	-2044	10884
ECSIT	-6333	10115
ETFA	-3727	-7917
ETFB	-10912	576
ETFDH	2376	356
LRPPRC	-7531	-9087
MT-CO1	9067	13178
MT-CO2	8603	13180
MT-CO3	8245	13176
MT-CYB	5991	13184
MT-ND1	5209	13177
MT-ND2	-1457	13183
MT-ND3	6571	13181
MT-ND4	566	13174
MT-ND5	4289	13012
MT-ND6	4676	13045
NDUFA1	-6222	13127
NDUFA10	-7241	-4286
NDUFA11	9807	12851
NDUFA12	6720	13049
NDUFA13	-4424	12971
NDUFA2	5937	13125
NDUFA3	-4508	13084
NDUFA4	9132	11345
NDUFA5	-6593	11094
NDUFA6	-10640	12901
NDUFA7	8872	13143
NDUFA8	-8774	12900
NDUFA9	2605	10360
NDUFAB1	-10558	8746
NDUFAF1	2883	9463
NDUFAF2	-5167	12574
NDUFAF3	10175	13112
NDUFAF4	-8760	9608
NDUFAF5	-3460	9719
NDUFAF6	-5625	10508
NDUFAF7	6751	8883
NDUFB1	8092	13163
NDUFB10	-9687	12582
NDUFB11	-7090	11583
NDUFB2	11367	12511
NDUFB3	1661	12046
NDUFB4	8888	13008
NDUFB5	-3244	-5075
NDUFB6	-8238	12165
NDUFB7	-4205	12444
NDUFB8	8367	13039
NDUFB9	-8544	12805
NDUFC1	-7186	12437
NDUFC2	-5184	11409
NDUFS1	-9609	-7041
NDUFS2	3967	-10068
NDUFS3	-8653	12725
NDUFS4	6388	3949
NDUFS5	-6394	13145
NDUFS6	-6327	12108
NDUFS7	5531	12411
NDUFS8	-7989	12773
NDUFV1	-5404	8980
NDUFV2	-6865	13148
NDUFV3	-6779	12304
NUBPL	8039	-8010
SCO1	-10631	-6537
SCO2	-9739	9526
SDHA	-10480	-9986
SDHB	-299	5982
SDHC	9345	-5559
SDHD	-9641	-2716
SURF1	8003	9112
TACO1	8239	8081
TIMMDC1	9211	-3329
TMEM126B	-8036	9815
TMEM186	-8187	5086
TRAP1	-11197	8602
UQCR10	-9028	12920
UQCR11	-5675	11509
UQCRB	-979	12923
UQCRC1	8588	-1762
UQCRC2	-11089	-6026
UQCRFS1	-10915	-8657
UQCRH	-8039	12733
UQCRQ	10244	13147

---

---

Regulation of localization of FOXO transcription factors

Regulation of localization of FOXO transcription factors

metric	value
setSize	12
pMANOVA	0.00154
p.adjustMANOVA	0.00324
s.dist	0.58
s.KO	0.206
s.drug	-0.542
p.KO	0.216
p.drug	0.00115

Top 20 genes

Gene	KO	drug
YWHAQ	7979	-10945
FOXO1	7945	-10183
YWHAB	11096	-6543
AKT3	6626	-10834
FOXO4	7396	-7380
SFN	5633	-2792

Click HERE to show all gene set members

All member genes

	KO	drug
AKT1	-1733	-1215
AKT2	9732	3410
AKT3	6626	-10834
FOXO1	7945	-10183
FOXO3	-9950	-10606
FOXO4	7396	-7380
FOXO6	7392	9947
SFN	5633	-2792
YWHAB	11096	-6543
YWHAG	-8344	-10868
YWHAQ	7979	-10945
YWHAZ	-5429	-10168

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.2.2              echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.1               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58                 fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [23] IRanges_2.30.0              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.9                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.7                ggplot2_3.3.6              
## [35] tidyverse_1.3.1             zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.7             polylabelr_0.2.0      
##   [7] splines_4.2.1          BiocParallel_1.30.3    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.3            magrittr_2.0.3        
##  [13] memoise_2.0.1          tzdb_0.3.0             Biostrings_2.64.0     
##  [16] annotate_1.74.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.3             rvest_1.0.2           
##  [22] haven_2.5.0            xfun_0.31              crayon_1.5.1          
##  [25] RCurl_1.98-1.7         jsonlite_1.8.0         genefilter_1.78.0     
##  [28] survival_3.4-0         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.42.0        XVector_0.36.0        
##  [34] webshot_0.5.3          DelayedArray_0.22.0    scales_1.2.0          
##  [37] DBI_1.1.3              Rcpp_1.0.8.3           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.3             RColorBrewer_1.1-3     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.9         
##  [49] XML_3.99-0.10          sass_0.4.1             dbplyr_2.2.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.3            later_1.3.0           
##  [58] AnnotationDbi_1.58.0   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.1            cachem_1.0.6           cli_3.3.0             
##  [64] generics_0.1.2         RSQLite_2.2.14         broom_0.8.0           
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.39             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.36.2        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.1         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.74.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] lattice_0.20-45        Matrix_1.4-1           vctrs_0.4.1           
##  [88] pillar_1.7.0           lifecycle_1.0.1        jquerylib_0.1.4       
##  [91] data.table_1.14.2      bitops_1.0-7           httpuv_1.6.5          
##  [94] R6_2.5.1               promises_1.2.0.1       KernSmooth_2.23-20    
##  [97] gridExtra_2.3          codetools_0.2-18       assertthat_0.2.1      
## [100] withr_2.5.0            GenomeInfoDbData_1.2.8 parallel_4.2.1        
## [103] hms_1.1.1              grid_4.2.1             rmarkdown_2.14        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report