date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA -0.4520464
## 7SK       -2.2982399
## A1BG      -3.3008939
## A1BG-AS1   0.3211569
## A1CF      -0.7352419
## A2M       30.2687300
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2512
num_genes_in_profile 25203
duplicated_genes_present 0
num_profile_genes_in_sets 8951
num_profile_genes_not_in_sets 16252

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2512
num_genesets_excluded 1040
num_genesets_included 1472

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Receptor Mediated Mitophagy 11 8.03e-06 -0.777 6.39e-05
Mucopolysaccharidoses 11 1.17e-05 0.763 9.08e-05
Membrane binding and targetting of GAG proteins 14 4.02e-05 -0.634 2.67e-04
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 4.02e-05 -0.634 2.67e-04
Unwinding of DNA 12 2.83e-04 0.605 1.48e-03
Assembly Of The HIV Virion 16 3.24e-05 -0.600 2.24e-04
Biotin transport and metabolism 11 1.11e-03 0.568 4.71e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.32e-08 -0.563 1.56e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.85e-03 -0.542 7.38e-03
Signaling by Activin 15 3.30e-04 -0.535 1.66e-03
Mitophagy 28 1.15e-06 -0.531 1.16e-05
Response of EIF2AK1 (HRI) to heme deficiency 15 5.01e-04 -0.519 2.38e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 8.03e-12 -0.519 3.03e-10
Hyaluronan uptake and degradation 10 4.77e-03 0.515 1.67e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.12e-05 -0.513 2.19e-04
Translation initiation complex formation 57 2.55e-11 -0.510 8.17e-10
Lysosphingolipid and LPA receptors 12 2.41e-03 -0.506 9.22e-03
rRNA modification in the nucleus and cytosol 60 1.68e-11 -0.502 5.49e-10
HIV elongation arrest and recovery 32 9.16e-07 -0.501 9.56e-06
Pausing and recovery of HIV elongation 32 9.16e-07 -0.501 9.56e-06
SLBP independent Processing of Histone Pre-mRNAs 10 6.10e-03 -0.501 2.09e-02
Formation of the ternary complex, and subsequently, the 43S complex 50 1.07e-09 -0.498 2.76e-08
Protein methylation 15 9.68e-04 -0.492 4.13e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 11 4.89e-03 -0.490 1.71e-02
Deadenylation of mRNA 22 7.05e-05 -0.489 4.47e-04
Pausing and recovery of Tat-mediated HIV elongation 30 3.50e-06 -0.489 3.03e-05
Tat-mediated HIV elongation arrest and recovery 30 3.50e-06 -0.489 3.03e-05
PERK regulates gene expression 32 1.83e-06 -0.487 1.76e-05
Ribosomal scanning and start codon recognition 57 2.24e-10 -0.485 6.48e-09
Hyaluronan metabolism 14 1.74e-03 0.483 6.98e-03
Josephin domain DUBs 10 8.31e-03 -0.482 2.70e-02
ROS sensing by NFE2L2 55 6.27e-10 -0.482 1.74e-08
Nucleotide biosynthesis 12 3.87e-03 -0.482 1.39e-02
Spry regulation of FGF signaling 16 8.95e-04 -0.480 3.86e-03
Formation of HIV elongation complex in the absence of HIV Tat 44 4.82e-08 -0.475 9.47e-07
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.77e-07 -0.465 2.64e-06
HIV Transcription Elongation 42 1.77e-07 -0.465 2.64e-06
Tat-mediated elongation of the HIV-1 transcript 42 1.77e-07 -0.465 2.64e-06
ATF4 activates genes in response to endoplasmic reticulum stress 27 2.91e-05 -0.465 2.05e-04
L13a-mediated translational silencing of Ceruloplasmin expression 109 5.40e-17 -0.464 5.30e-15
FOXO-mediated transcription of cell death genes 15 1.86e-03 -0.464 7.40e-03
DNA strand elongation 32 5.53e-06 0.464 4.62e-05
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.27e-04 -0.462 7.32e-04
Folding of actin by CCT/TriC 10 1.19e-02 -0.459 3.64e-02
Regulation of RUNX3 expression and activity 54 6.91e-09 -0.456 1.64e-07
Regulation of PTEN mRNA translation 12 6.62e-03 -0.453 2.22e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 2.46e-03 -0.452 9.37e-03
rRNA processing in the nucleus and cytosol 190 8.93e-27 -0.450 3.29e-24
Citric acid cycle (TCA cycle) 22 2.86e-04 -0.447 1.49e-03
KSRP (KHSRP) binds and destabilizes mRNA 17 1.47e-03 -0.446 6.03e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Receptor Mediated Mitophagy 11 8.03e-06 -7.77e-01 6.39e-05
Mucopolysaccharidoses 11 1.17e-05 7.63e-01 9.08e-05
Membrane binding and targetting of GAG proteins 14 4.02e-05 -6.34e-01 2.67e-04
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 4.02e-05 -6.34e-01 2.67e-04
Unwinding of DNA 12 2.83e-04 6.05e-01 1.48e-03
Assembly Of The HIV Virion 16 3.24e-05 -6.00e-01 2.24e-04
Biotin transport and metabolism 11 1.11e-03 5.68e-01 4.71e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.32e-08 -5.63e-01 1.56e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.85e-03 -5.42e-01 7.38e-03
Signaling by Activin 15 3.30e-04 -5.35e-01 1.66e-03
Mitophagy 28 1.15e-06 -5.31e-01 1.16e-05
Response of EIF2AK1 (HRI) to heme deficiency 15 5.01e-04 -5.19e-01 2.38e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 8.03e-12 -5.19e-01 3.03e-10
Hyaluronan uptake and degradation 10 4.77e-03 5.15e-01 1.67e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.12e-05 -5.13e-01 2.19e-04
Translation initiation complex formation 57 2.55e-11 -5.10e-01 8.17e-10
Lysosphingolipid and LPA receptors 12 2.41e-03 -5.06e-01 9.22e-03
rRNA modification in the nucleus and cytosol 60 1.68e-11 -5.02e-01 5.49e-10
HIV elongation arrest and recovery 32 9.16e-07 -5.01e-01 9.56e-06
Pausing and recovery of HIV elongation 32 9.16e-07 -5.01e-01 9.56e-06
SLBP independent Processing of Histone Pre-mRNAs 10 6.10e-03 -5.01e-01 2.09e-02
Formation of the ternary complex, and subsequently, the 43S complex 50 1.07e-09 -4.98e-01 2.76e-08
Protein methylation 15 9.68e-04 -4.92e-01 4.13e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 11 4.89e-03 -4.90e-01 1.71e-02
Deadenylation of mRNA 22 7.05e-05 -4.89e-01 4.47e-04
Pausing and recovery of Tat-mediated HIV elongation 30 3.50e-06 -4.89e-01 3.03e-05
Tat-mediated HIV elongation arrest and recovery 30 3.50e-06 -4.89e-01 3.03e-05
PERK regulates gene expression 32 1.83e-06 -4.87e-01 1.76e-05
Ribosomal scanning and start codon recognition 57 2.24e-10 -4.85e-01 6.48e-09
Hyaluronan metabolism 14 1.74e-03 4.83e-01 6.98e-03
Josephin domain DUBs 10 8.31e-03 -4.82e-01 2.70e-02
ROS sensing by NFE2L2 55 6.27e-10 -4.82e-01 1.74e-08
Nucleotide biosynthesis 12 3.87e-03 -4.82e-01 1.39e-02
Spry regulation of FGF signaling 16 8.95e-04 -4.80e-01 3.86e-03
Formation of HIV elongation complex in the absence of HIV Tat 44 4.82e-08 -4.75e-01 9.47e-07
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.77e-07 -4.65e-01 2.64e-06
HIV Transcription Elongation 42 1.77e-07 -4.65e-01 2.64e-06
Tat-mediated elongation of the HIV-1 transcript 42 1.77e-07 -4.65e-01 2.64e-06
ATF4 activates genes in response to endoplasmic reticulum stress 27 2.91e-05 -4.65e-01 2.05e-04
L13a-mediated translational silencing of Ceruloplasmin expression 109 5.40e-17 -4.64e-01 5.30e-15
FOXO-mediated transcription of cell death genes 15 1.86e-03 -4.64e-01 7.40e-03
DNA strand elongation 32 5.53e-06 4.64e-01 4.62e-05
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.27e-04 -4.62e-01 7.32e-04
Folding of actin by CCT/TriC 10 1.19e-02 -4.59e-01 3.64e-02
Regulation of RUNX3 expression and activity 54 6.91e-09 -4.56e-01 1.64e-07
Regulation of PTEN mRNA translation 12 6.62e-03 -4.53e-01 2.22e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 2.46e-03 -4.52e-01 9.37e-03
rRNA processing in the nucleus and cytosol 190 8.93e-27 -4.50e-01 3.29e-24
Citric acid cycle (TCA cycle) 22 2.86e-04 -4.47e-01 1.49e-03
KSRP (KHSRP) binds and destabilizes mRNA 17 1.47e-03 -4.46e-01 6.03e-03
CS/DS degradation 14 4.08e-03 4.43e-01 1.46e-02
p75NTR signals via NF-kB 16 2.18e-03 -4.42e-01 8.42e-03
Formation of a pool of free 40S subunits 99 2.84e-14 -4.42e-01 1.74e-12
Postmitotic nuclear pore complex (NPC) reformation 27 7.20e-05 -4.41e-01 4.51e-04
Processive synthesis on the lagging strand 15 3.13e-03 4.41e-01 1.16e-02
Major pathway of rRNA processing in the nucleolus and cytosol 180 2.10e-24 -4.40e-01 4.42e-22
GTP hydrolysis and joining of the 60S ribosomal subunit 110 1.53e-15 -4.40e-01 1.25e-13
RHOBTB1 GTPase cycle 23 2.63e-04 -4.40e-01 1.40e-03
Alpha-protein kinase 1 signaling pathway 11 1.17e-02 -4.39e-01 3.59e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 1.21e-02 -4.37e-01 3.70e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.71e-07 -4.36e-01 2.63e-06
PINK1-PRKN Mediated Mitophagy 21 5.78e-04 -4.34e-01 2.66e-03
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 2.91e-05 -4.34e-01 2.05e-04
Leading Strand Synthesis 14 4.97e-03 4.34e-01 1.73e-02
Polymerase switching 14 4.97e-03 4.34e-01 1.73e-02
Mitochondrial iron-sulfur cluster biogenesis 13 6.85e-03 -4.33e-01 2.29e-02
Formation of the Early Elongation Complex 33 1.86e-05 -4.30e-01 1.40e-04
Formation of the HIV-1 Early Elongation Complex 33 1.86e-05 -4.30e-01 1.40e-04
Vif-mediated degradation of APOBEC3G 52 8.04e-08 -4.30e-01 1.44e-06
Reduction of cytosolic Ca++ levels 12 9.90e-03 4.30e-01 3.15e-02
Cholesterol biosynthesis 24 2.72e-04 -4.29e-01 1.43e-03
HS-GAG degradation 19 1.23e-03 4.28e-01 5.15e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 12 1.06e-02 -4.26e-01 3.32e-02
Nuclear events stimulated by ALK signaling in cancer 19 1.33e-03 -4.25e-01 5.49e-03
Deadenylation-dependent mRNA decay 53 8.57e-08 -4.25e-01 1.50e-06
Removal of the Flap Intermediate 14 6.07e-03 4.23e-01 2.09e-02
Autodegradation of the E3 ubiquitin ligase COP1 49 2.96e-07 -4.23e-01 3.92e-06
Degradation of DVL 55 5.65e-08 -4.23e-01 1.05e-06
Stabilization of p53 53 1.02e-07 -4.22e-01 1.67e-06
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 2.36e-07 -4.22e-01 3.24e-06
p53-Independent DNA Damage Response 50 2.36e-07 -4.22e-01 3.24e-06
p53-Independent G1/S DNA damage checkpoint 50 2.36e-07 -4.22e-01 3.24e-06
Golgi Cisternae Pericentriolar Stack Reorganization 14 6.30e-03 -4.22e-01 2.15e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 2.10e-12 -4.21e-01 8.83e-11
SUMOylation of immune response proteins 11 1.56e-02 -4.21e-01 4.57e-02
Cap-dependent Translation Initiation 117 3.65e-15 -4.21e-01 2.57e-13
Eukaryotic Translation Initiation 117 3.65e-15 -4.21e-01 2.57e-13
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 4.68e-13 -4.20e-01 2.37e-11
The activation of arylsulfatases 10 2.15e-02 4.20e-01 6.08e-02
Peptide chain elongation 87 1.27e-11 -4.20e-01 4.46e-10
Cell-extracellular matrix interactions 16 3.83e-03 -4.18e-01 1.39e-02
Viral mRNA Translation 87 1.63e-11 -4.18e-01 5.45e-10
SCF-beta-TrCP mediated degradation of Emi1 53 1.45e-07 -4.17e-01 2.27e-06
Defective CFTR causes cystic fibrosis 58 4.93e-08 -4.14e-01 9.55e-07
Regulation of Apoptosis 51 3.42e-07 -4.13e-01 4.41e-06
SUMOylation of SUMOylation proteins 35 2.71e-05 -4.10e-01 1.94e-04
Eukaryotic Translation Elongation 92 1.13e-11 -4.09e-01 4.07e-10
Regulation of HMOX1 expression and activity 63 2.11e-08 -4.08e-01 4.38e-07
Vpu mediated degradation of CD4 50 7.38e-07 -4.05e-01 7.99e-06
Transport of the SLBP Dependant Mature mRNA 36 2.81e-05 -4.03e-01 2.01e-04
mRNA Capping 29 1.73e-04 -4.03e-01 9.57e-04
Dectin-1 mediated noncanonical NF-kB signaling 59 8.62e-08 -4.03e-01 1.50e-06
Hh mutants are degraded by ERAD 54 3.14e-07 -4.02e-01 4.10e-06
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 45 3.38e-06 -4.00e-01 2.96e-05
NIK–>noncanonical NF-kB signaling 57 1.80e-07 -3.99e-01 2.64e-06
Eukaryotic Translation Termination 91 4.52e-11 -3.99e-01 1.42e-09
Regulation of ornithine decarboxylase (ODC) 49 1.33e-06 -3.99e-01 1.31e-05
TICAM1, RIP1-mediated IKK complex recruitment 18 3.41e-03 -3.99e-01 1.24e-02
MET activates RAP1 and RAC1 11 2.21e-02 -3.98e-01 6.23e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 9.94e-03 3.98e-01 3.15e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.59e-03 -3.97e-01 1.63e-02
FGFR2 alternative splicing 26 4.72e-04 -3.96e-01 2.27e-03
Degradation of AXIN 53 6.50e-07 -3.95e-01 7.19e-06
HDACs deacetylate histones 52 8.37e-07 -3.95e-01 8.99e-06
rRNA processing 214 2.61e-23 -3.94e-01 4.81e-21
Transport of Mature mRNAs Derived from Intronless Transcripts 43 7.88e-06 -3.94e-01 6.30e-05
STING mediated induction of host immune responses 15 8.41e-03 -3.93e-01 2.71e-02
Neurotoxicity of clostridium toxins 10 3.15e-02 3.93e-01 8.24e-02
Downregulation of TGF-beta receptor signaling 26 5.63e-04 -3.91e-01 2.60e-03
SRP-dependent cotranslational protein targeting to membrane 110 1.47e-12 -3.90e-01 6.35e-11
Metabolism of polyamines 57 3.46e-07 -3.90e-01 4.43e-06
The role of GTSE1 in G2/M progression after G2 checkpoint 58 2.85e-07 -3.89e-01 3.82e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 8.41e-13 -3.89e-01 3.97e-11
Nonsense-Mediated Decay (NMD) 113 8.41e-13 -3.89e-01 3.97e-11
Formation of RNA Pol II elongation complex 57 3.67e-07 -3.89e-01 4.59e-06
RNA Polymerase II Transcription Elongation 57 3.67e-07 -3.89e-01 4.59e-06
Activation of the TFAP2 (AP-2) family of transcription factors 11 2.60e-02 -3.88e-01 7.04e-02
Transport of the SLBP independent Mature mRNA 35 7.26e-05 -3.87e-01 4.53e-04
Regulation of IFNG signaling 13 1.60e-02 -3.86e-01 4.66e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 5.29e-04 -3.85e-01 2.46e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 5.29e-04 -3.85e-01 2.46e-03
Influenza Viral RNA Transcription and Replication 134 1.52e-14 -3.84e-01 1.02e-12
Synthesis of PIPs at the late endosome membrane 11 2.78e-02 -3.83e-01 7.39e-02
Vpr-mediated nuclear import of PICs 34 1.14e-04 -3.82e-01 6.70e-04
Negative regulators of DDX58/IFIH1 signaling 35 9.26e-05 -3.82e-01 5.57e-04
RHO GTPases activate KTN1 11 2.84e-02 -3.82e-01 7.50e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.52e-06 -3.82e-01 1.48e-05
Negative regulation of NOTCH4 signaling 54 1.26e-06 -3.81e-01 1.25e-05
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.99e-05 -3.80e-01 1.49e-04
Regulation of RUNX2 expression and activity 70 3.71e-08 -3.80e-01 7.48e-07
Lagging Strand Synthesis 20 3.36e-03 3.79e-01 1.24e-02
IRAK2 mediated activation of TAK1 complex 10 3.81e-02 -3.79e-01 9.61e-02
Transcription of the HIV genome 69 5.44e-08 -3.78e-01 1.03e-06
Asymmetric localization of PCP proteins 62 2.80e-07 -3.77e-01 3.79e-06
RNA polymerase II transcribes snRNA genes 71 3.97e-08 -3.77e-01 7.91e-07
N-Glycan antennae elongation 14 1.47e-02 -3.77e-01 4.38e-02
Cross-presentation of soluble exogenous antigens (endosomes) 45 1.23e-05 -3.77e-01 9.45e-05
CLEC7A (Dectin-1) signaling 97 1.44e-10 -3.76e-01 4.23e-09
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 1.46e-04 -3.76e-01 8.22e-04
FCERI mediated NF-kB activation 75 1.74e-08 -3.76e-01 3.77e-07
RNA Polymerase III Transcription Termination 23 1.82e-03 -3.76e-01 7.27e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.25e-06 -3.75e-01 2.10e-05
ATF6 (ATF6-alpha) activates chaperone genes 10 4.00e-02 -3.75e-01 9.96e-02
p130Cas linkage to MAPK signaling for integrins 12 2.45e-02 -3.75e-01 6.74e-02
Activation of NF-kappaB in B cells 65 1.86e-07 -3.74e-01 2.71e-06
Rev-mediated nuclear export of HIV RNA 35 1.33e-04 -3.73e-01 7.63e-04
Downregulation of SMAD2/3:SMAD4 transcriptional activity 28 6.35e-04 -3.73e-01 2.87e-03
Pentose phosphate pathway 13 2.03e-02 -3.72e-01 5.77e-02
Late Phase of HIV Life Cycle 135 1.07e-13 -3.70e-01 6.05e-12
Formation of TC-NER Pre-Incision Complex 53 3.66e-06 -3.67e-01 3.14e-05
Metabolism of Angiotensinogen to Angiotensins 11 3.57e-02 3.66e-01 9.16e-02
Interactions of Rev with host cellular proteins 37 1.18e-04 -3.66e-01 6.88e-04
APC/C:Cdc20 mediated degradation of Securin 66 2.78e-07 -3.66e-01 3.79e-06
p53-Dependent G1 DNA Damage Response 62 6.42e-07 -3.65e-01 7.16e-06
p53-Dependent G1/S DNA damage checkpoint 62 6.42e-07 -3.65e-01 7.16e-06
Degradation of GLI1 by the proteasome 57 1.84e-06 -3.65e-01 1.76e-05
RNA Polymerase III Abortive And Retractive Initiation 41 5.37e-05 -3.64e-01 3.45e-04
RNA Polymerase III Transcription 41 5.37e-05 -3.64e-01 3.45e-04
Ubiquitin-dependent degradation of Cyclin D 50 8.51e-06 -3.64e-01 6.70e-05
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.65e-02 3.63e-01 1.12e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 9.64e-08 -3.63e-01 1.59e-06
Viral Messenger RNA Synthesis 44 3.25e-05 -3.62e-01 2.24e-04
TGF-beta receptor signaling activates SMADs 32 3.96e-04 -3.62e-01 1.97e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 2.40e-02 3.61e-01 6.63e-02
Defective EXT2 causes exostoses 2 13 2.40e-02 3.61e-01 6.63e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.02e-02 -3.60e-01 3.21e-02
HATs acetylate histones 99 6.61e-10 -3.59e-01 1.80e-08
HIV Life Cycle 147 5.85e-14 -3.59e-01 3.44e-12
Hh mutants abrogate ligand secretion 57 2.95e-06 -3.58e-01 2.62e-05
Signaling by NODAL 19 6.99e-03 -3.57e-01 2.32e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 8.79e-08 -3.57e-01 1.50e-06
Nuclear import of Rev protein 34 3.16e-04 -3.57e-01 1.60e-03
NF-kB is activated and signals survival 13 2.66e-02 -3.55e-01 7.10e-02
Influenza Infection 154 2.69e-14 -3.55e-01 1.72e-12
Regulation of expression of SLITs and ROBOs 166 3.66e-15 -3.53e-01 2.57e-13
HDMs demethylate histones 22 4.13e-03 -3.53e-01 1.47e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism 19 7.78e-03 -3.53e-01 2.55e-02
Protein ubiquitination 73 1.91e-07 -3.52e-01 2.73e-06
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 4.31e-02 3.52e-01 1.06e-01
Selenocysteine synthesis 91 6.27e-09 -3.52e-01 1.51e-07
Signaling by BMP 23 3.48e-03 -3.52e-01 1.26e-02
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.12e-06 -3.52e-01 1.14e-05
ERK/MAPK targets 22 4.33e-03 -3.51e-01 1.54e-02
G1/S DNA Damage Checkpoints 64 1.17e-06 -3.51e-01 1.18e-05
Transport of Mature Transcript to Cytoplasm 81 5.15e-08 -3.50e-01 9.85e-07
APC/C:Cdc20 mediated degradation of mitotic proteins 74 2.02e-07 -3.49e-01 2.87e-06
Signaling by FGFR2 IIIa TM 19 8.43e-03 -3.49e-01 2.71e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.72e-02 -3.47e-01 9.42e-02
TBC/RABGAPs 43 9.17e-05 -3.45e-01 5.53e-04
p75NTR recruits signalling complexes 13 3.16e-02 -3.44e-01 8.26e-02
Budding and maturation of HIV virion 28 1.63e-03 -3.44e-01 6.59e-03
ABC transporters in lipid homeostasis 15 2.11e-02 3.44e-01 5.99e-02
APC truncation mutants have impaired AXIN binding 14 2.64e-02 -3.43e-01 7.05e-02
AXIN missense mutants destabilize the destruction complex 14 2.64e-02 -3.43e-01 7.05e-02
Signaling by AMER1 mutants 14 2.64e-02 -3.43e-01 7.05e-02
Signaling by APC mutants 14 2.64e-02 -3.43e-01 7.05e-02
Signaling by AXIN mutants 14 2.64e-02 -3.43e-01 7.05e-02
Truncations of AMER1 destabilize the destruction complex 14 2.64e-02 -3.43e-01 7.05e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 2.20e-06 -3.42e-01 2.06e-05
Interactions of Vpr with host cellular proteins 37 3.20e-04 -3.42e-01 1.62e-03
Signaling by TGF-beta Receptor Complex 74 3.68e-07 -3.42e-01 4.59e-06
Host Interactions of HIV factors 124 4.97e-11 -3.41e-01 1.52e-09
HIV Infection 222 1.89e-18 -3.41e-01 2.14e-16
Gastrin-CREB signalling pathway via PKC and MAPK 17 1.51e-02 -3.40e-01 4.46e-02
SUMOylation of ubiquitinylation proteins 39 2.35e-04 -3.40e-01 1.27e-03
Activation of RAC1 13 3.43e-02 -3.39e-01 8.82e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 6.80e-07 -3.38e-01 7.47e-06
RNA Polymerase II Pre-transcription Events 80 1.65e-07 -3.38e-01 2.56e-06
CDT1 association with the CDC6:ORC:origin complex 57 1.14e-05 -3.36e-01 8.90e-05
Activation of gene expression by SREBF (SREBP) 42 1.67e-04 -3.36e-01 9.30e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 1.07e-06 -3.35e-01 1.10e-05
Regulation of mRNA stability by proteins that bind AU-rich elements 87 6.95e-08 -3.34e-01 1.28e-06
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 9.37e-07 -3.34e-01 9.71e-06
Regulation of TP53 Activity through Acetylation 29 1.91e-03 -3.33e-01 7.57e-03
Selenoamino acid metabolism 115 7.23e-10 -3.32e-01 1.90e-08
Defective B3GAT3 causes JDSSDHD 19 1.23e-02 3.32e-01 3.75e-02
G1/S-Specific Transcription 29 2.03e-03 3.31e-01 7.99e-03
ERKs are inactivated 13 3.89e-02 -3.31e-01 9.74e-02
Processing of Capped Intronless Pre-mRNA 28 2.46e-03 -3.31e-01 9.37e-03
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 1.27e-02 3.30e-01 3.86e-02
Processing of Capped Intron-Containing Pre-mRNA 238 1.68e-18 -3.30e-01 2.06e-16
Transcriptional activation of mitochondrial biogenesis 53 3.27e-05 -3.30e-01 2.24e-04
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.25e-03 -3.30e-01 5.21e-03
Antiviral mechanism by IFN-stimulated genes 81 3.08e-07 -3.29e-01 4.05e-06
UCH proteinases 90 7.25e-08 -3.28e-01 1.32e-06
Other semaphorin interactions 16 2.30e-02 3.28e-01 6.43e-02
Interferon alpha/beta signaling 56 2.24e-05 -3.27e-01 1.66e-04
NS1 Mediated Effects on Host Pathways 41 2.92e-04 -3.27e-01 1.51e-03
Defective B4GALT7 causes EDS, progeroid type 19 1.37e-02 3.27e-01 4.12e-02
Regulation of RAS by GAPs 64 6.33e-06 -3.26e-01 5.22e-05
Interleukin-12 signaling 43 2.22e-04 -3.25e-01 1.20e-03
Regulation of APC/C activators between G1/S and early anaphase 79 5.74e-07 -3.25e-01 6.55e-06
Downstream signaling events of B Cell Receptor (BCR) 79 6.05e-07 -3.25e-01 6.85e-06
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 8.43e-03 -3.24e-01 2.71e-02
Diseases of carbohydrate metabolism 30 2.13e-03 3.24e-01 8.27e-03
Regulation of PTEN stability and activity 67 4.69e-06 -3.23e-01 3.97e-05
Cellular response to hypoxia 72 2.15e-06 -3.23e-01 2.03e-05
Glycosphingolipid metabolism 42 2.94e-04 3.23e-01 1.51e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.59e-03 -3.22e-01 6.48e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.59e-03 -3.22e-01 6.48e-03
Signaling by TGFB family members 98 3.55e-08 -3.22e-01 7.25e-07
Degradation of GLI2 by the proteasome 57 2.61e-05 -3.22e-01 1.88e-04
Degradation of beta-catenin by the destruction complex 83 3.98e-07 -3.22e-01 4.88e-06
Processing and activation of SUMO 10 7.82e-02 -3.22e-01 1.73e-01
SUMOylation of DNA replication proteins 46 1.74e-04 -3.20e-01 9.58e-04
Interleukin-6 signaling 11 6.65e-02 -3.19e-01 1.52e-01
Cellular response to starvation 150 1.48e-11 -3.19e-01 5.07e-10
Downstream signal transduction 29 2.97e-03 -3.19e-01 1.12e-02
GLI3 is processed to GLI3R by the proteasome 57 3.20e-05 -3.18e-01 2.24e-04
Nuclear Events (kinase and transcription factor activation) 60 2.02e-05 -3.18e-01 1.50e-04
Transport of Ribonucleoproteins into the Host Nucleus 32 1.91e-03 -3.17e-01 7.57e-03
Hedgehog ‘on’ state 84 5.13e-07 -3.17e-01 5.99e-06
The NLRP3 inflammasome 15 3.37e-02 -3.17e-01 8.68e-02
Metabolism of RNA 677 4.67e-45 -3.16e-01 6.87e-42
ISG15 antiviral mechanism 73 3.00e-06 -3.16e-01 2.64e-05
Interleukin-1 signaling 96 8.64e-08 -3.16e-01 1.50e-06
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.07e-02 3.16e-01 1.01e-01
Metabolism of non-coding RNA 53 6.95e-05 -3.16e-01 4.43e-04
snRNP Assembly 53 6.95e-05 -3.16e-01 4.43e-04
NGF-stimulated transcription 38 7.82e-04 -3.15e-01 3.48e-03
Trafficking of GluR2-containing AMPA receptors 16 2.99e-02 3.14e-01 7.84e-02
APC/C-mediated degradation of cell cycle proteins 86 4.98e-07 -3.13e-01 5.87e-06
Regulation of mitotic cell cycle 86 4.98e-07 -3.13e-01 5.87e-06
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.54e-03 -3.13e-01 9.61e-03
Chromatin modifying enzymes 222 8.47e-16 -3.13e-01 7.33e-14
Chromatin organization 222 8.47e-16 -3.13e-01 7.33e-14
Mismatch Repair 15 3.59e-02 3.13e-01 9.18e-02
Cellular response to heat stress 95 1.39e-07 -3.13e-01 2.19e-06
Ovarian tumor domain proteases 38 8.61e-04 -3.12e-01 3.77e-03
Chondroitin sulfate biosynthesis 20 1.58e-02 3.12e-01 4.62e-02
TNFR1-induced proapoptotic signaling 13 5.18e-02 -3.12e-01 1.24e-01
Cytosolic tRNA aminoacylation 24 8.35e-03 -3.11e-01 2.71e-02
mRNA decay by 3’ to 5’ exoribonuclease 16 3.20e-02 -3.10e-01 8.34e-02
mRNA Splicing - Major Pathway 179 8.64e-13 -3.10e-01 3.97e-11
mRNA Splicing - Minor Pathway 52 1.15e-04 -3.09e-01 6.74e-04
CDK-mediated phosphorylation and removal of Cdc6 71 6.76e-06 -3.09e-01 5.53e-05
Negative regulation of FGFR1 signaling 30 3.42e-03 -3.09e-01 1.24e-02
Packaging Of Telomere Ends 24 9.00e-03 -3.08e-01 2.89e-02
Regulation of HSF1-mediated heat shock response 78 2.86e-06 -3.06e-01 2.58e-05
RNA Polymerase III Transcription Initiation 36 1.47e-03 -3.06e-01 6.03e-03
Unfolded Protein Response (UPR) 91 4.44e-07 -3.06e-01 5.35e-06
CLEC7A (Dectin-1) induces NFAT activation 11 7.94e-02 -3.05e-01 1.75e-01
Inflammasomes 19 2.17e-02 -3.04e-01 6.13e-02
STAT5 activation downstream of FLT3 ITD mutants 10 9.74e-02 -3.03e-01 2.02e-01
Fc epsilon receptor (FCERI) signaling 126 5.04e-09 -3.01e-01 1.24e-07
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.95e-03 -3.00e-01 2.32e-02
CTLA4 inhibitory signaling 17 3.23e-02 -3.00e-01 8.41e-02
HCMV Early Events 80 3.60e-06 -3.00e-01 3.10e-05
HIV Transcription Initiation 47 4.04e-04 -2.98e-01 1.98e-03
RNA Polymerase II HIV Promoter Escape 47 4.04e-04 -2.98e-01 1.98e-03
RNA Polymerase II Promoter Escape 47 4.04e-04 -2.98e-01 1.98e-03
RNA Polymerase II Transcription Initiation 47 4.04e-04 -2.98e-01 1.98e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 47 4.04e-04 -2.98e-01 1.98e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 47 4.04e-04 -2.98e-01 1.98e-03
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 37 1.70e-03 -2.98e-01 6.86e-03
ER-Phagosome pathway 86 1.75e-06 -2.98e-01 1.70e-05
ER Quality Control Compartment (ERQC) 21 1.82e-02 -2.98e-01 5.23e-02
Synthesis of PIPs at the early endosome membrane 16 3.94e-02 -2.97e-01 9.84e-02
C-type lectin receptors (CLRs) 123 1.28e-08 -2.97e-01 2.81e-07
mRNA Splicing 187 2.68e-12 -2.96e-01 1.09e-10
Downstream TCR signaling 89 1.37e-06 -2.96e-01 1.35e-05
Establishment of Sister Chromatid Cohesion 11 8.94e-02 -2.96e-01 1.91e-01
Regulation of TP53 Degradation 35 2.48e-03 -2.95e-01 9.41e-03
RNA Polymerase II Transcription Termination 65 3.79e-05 -2.95e-01 2.55e-04
RNA Polymerase I Transcription Initiation 47 4.59e-04 -2.95e-01 2.22e-03
Export of Viral Ribonucleoproteins from Nucleus 33 3.39e-03 -2.95e-01 1.24e-02
A tetrasaccharide linker sequence is required for GAG synthesis 25 1.08e-02 2.94e-01 3.39e-02
Regulation of FOXO transcriptional activity by acetylation 10 1.08e-01 -2.93e-01 2.18e-01
Transcriptional regulation by RUNX3 94 8.95e-07 -2.93e-01 9.48e-06
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.98e-02 -2.92e-01 1.19e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 87 2.51e-06 -2.92e-01 2.31e-05
Signaling by ROBO receptors 211 3.20e-13 -2.91e-01 1.75e-11
Signal regulatory protein family interactions 11 9.55e-02 -2.90e-01 2.00e-01
Transcriptional regulation by small RNAs 68 3.58e-05 -2.90e-01 2.42e-04
Adherens junctions interactions 29 7.00e-03 2.89e-01 2.32e-02
N-glycan antennae elongation in the medial/trans-Golgi 25 1.25e-02 -2.89e-01 3.80e-02
Nuclear Pore Complex (NPC) Disassembly 36 2.79e-03 -2.88e-01 1.05e-02
Ub-specific processing proteases 175 5.25e-11 -2.87e-01 1.58e-09
E3 ubiquitin ligases ubiquitinate target proteins 53 2.99e-04 -2.87e-01 1.53e-03
Reactions specific to the complex N-glycan synthesis pathway 10 1.18e-01 -2.85e-01 2.32e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 34 4.01e-03 -2.85e-01 1.44e-02
Translation 293 4.15e-17 -2.85e-01 4.36e-15
DNA Damage Recognition in GG-NER 38 2.39e-03 -2.85e-01 9.18e-03
Inhibition of DNA recombination at telomere 39 2.10e-03 -2.85e-01 8.18e-03
Chondroitin sulfate/dermatan sulfate metabolism 49 6.01e-04 2.83e-01 2.74e-03
Cytoprotection by HMOX1 118 1.17e-07 -2.82e-01 1.89e-06
Defective B3GALTL causes PpS 37 3.00e-03 2.82e-01 1.12e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.85e-03 -2.82e-01 3.14e-02
PKMTs methylate histone lysines 45 1.13e-03 -2.80e-01 4.78e-03
Acyl chain remodelling of PI 10 1.25e-01 2.80e-01 2.42e-01
MAP kinase activation 63 1.21e-04 -2.80e-01 7.01e-04
Cytosolic sensors of pathogen-associated DNA 61 1.56e-04 -2.80e-01 8.72e-04
PTEN Regulation 140 1.06e-08 -2.80e-01 2.39e-07
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 1.55e-02 -2.80e-01 4.55e-02
Caspase activation via Dependence Receptors in the absence of ligand 10 1.26e-01 -2.79e-01 2.43e-01
IRF3-mediated induction of type I IFN 12 9.45e-02 -2.79e-01 1.99e-01
Regulation of IFNA signaling 12 9.51e-02 -2.78e-01 1.99e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 1.00e-04 -2.77e-01 5.96e-04
RHOBTB GTPase Cycle 35 4.68e-03 -2.76e-01 1.65e-02
SUMOylation of RNA binding proteins 47 1.05e-03 -2.76e-01 4.46e-03
Toll Like Receptor 3 (TLR3) Cascade 90 6.35e-06 -2.75e-01 5.22e-05
Prefoldin mediated transfer of substrate to CCT/TriC 27 1.36e-02 -2.74e-01 4.09e-02
TNFR2 non-canonical NF-kB pathway 90 6.86e-06 -2.74e-01 5.57e-05
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 7.57e-02 -2.74e-01 1.69e-01
Platelet sensitization by LDL 15 6.75e-02 -2.73e-01 1.54e-01
HCMV Late Events 76 3.97e-05 -2.73e-01 2.66e-04
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.02e-01 2.72e-01 2.10e-01
alpha-linolenic acid (ALA) metabolism 12 1.02e-01 2.72e-01 2.10e-01
Metabolism of amine-derived hormones 12 1.02e-01 2.72e-01 2.10e-01
Heme biosynthesis 13 9.05e-02 2.71e-01 1.93e-01
Laminin interactions 23 2.45e-02 2.71e-01 6.74e-02
Synthesis of PE 12 1.04e-01 -2.71e-01 2.13e-01
Interleukin-12 family signaling 51 8.21e-04 -2.71e-01 3.63e-03
SCF(Skp2)-mediated degradation of p27/p21 60 2.98e-04 -2.70e-01 1.53e-03
MAPK6/MAPK4 signaling 87 1.37e-05 -2.70e-01 1.04e-04
TNFR1-induced NFkappaB signaling pathway 26 1.75e-02 -2.69e-01 5.06e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 10 1.41e-01 -2.69e-01 2.66e-01
Defects in cobalamin (B12) metabolism 13 9.40e-02 -2.68e-01 1.98e-01
ABC transporter disorders 73 7.42e-05 -2.68e-01 4.61e-04
Beta-catenin phosphorylation cascade 17 5.57e-02 -2.68e-01 1.30e-01
Hedgehog ligand biogenesis 63 2.39e-04 -2.68e-01 1.28e-03
RNA Polymerase I Promoter Clearance 71 9.90e-05 -2.67e-01 5.90e-04
RNA Polymerase I Transcription 71 9.90e-05 -2.67e-01 5.90e-04
MyD88 cascade initiated on plasma membrane 81 3.30e-05 -2.67e-01 2.24e-04
Toll Like Receptor 10 (TLR10) Cascade 81 3.30e-05 -2.67e-01 2.24e-04
Toll Like Receptor 5 (TLR5) Cascade 81 3.30e-05 -2.67e-01 2.24e-04
EPHB-mediated forward signaling 34 7.15e-03 -2.67e-01 2.36e-02
Heparan sulfate/heparin (HS-GAG) metabolism 49 1.26e-03 2.66e-01 5.27e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.49e-02 -2.66e-01 4.43e-02
Signaling by PDGFRA extracellular domain mutants 12 1.13e-01 -2.64e-01 2.26e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.13e-01 -2.64e-01 2.26e-01
Signal transduction by L1 21 3.60e-02 -2.64e-01 9.18e-02
ADP signalling through P2Y purinoceptor 1 21 3.60e-02 -2.64e-01 9.18e-02
MicroRNA (miRNA) biogenesis 24 2.57e-02 -2.63e-01 6.97e-02
Deubiquitination 247 1.07e-12 -2.63e-01 4.78e-11
RNA Polymerase III Chain Elongation 18 5.37e-02 -2.63e-01 1.27e-01
Positive epigenetic regulation of rRNA expression 67 2.05e-04 -2.62e-01 1.13e-03
Circadian Clock 67 2.07e-04 -2.62e-01 1.13e-03
Lewis blood group biosynthesis 15 7.90e-02 -2.62e-01 1.75e-01
RHOBTB2 GTPase cycle 23 2.97e-02 -2.62e-01 7.81e-02
Regulation of TP53 Expression and Degradation 36 6.59e-03 -2.62e-01 2.21e-02
Nonhomologous End-Joining (NHEJ) 43 3.00e-03 -2.62e-01 1.12e-02
MET receptor recycling 10 1.53e-01 -2.61e-01 2.84e-01
Diseases associated with O-glycosylation of proteins 61 4.20e-04 2.61e-01 2.04e-03
Late endosomal microautophagy 29 1.53e-02 -2.60e-01 4.52e-02
IRE1alpha activates chaperones 50 1.48e-03 -2.60e-01 6.07e-03
Signal amplification 28 1.74e-02 -2.60e-01 5.04e-02
Cellular hexose transport 17 6.40e-02 2.59e-01 1.48e-01
GRB2 events in EGFR signaling 11 1.37e-01 -2.59e-01 2.60e-01
mRNA 3’-end processing 56 8.01e-04 -2.59e-01 3.55e-03
Interleukin-1 family signaling 127 4.71e-07 -2.59e-01 5.64e-06
TCR signaling 110 2.91e-06 -2.58e-01 2.61e-05
PCP/CE pathway 90 2.34e-05 -2.58e-01 1.71e-04
FCGR3A-mediated phagocytosis 56 8.66e-04 -2.57e-01 3.77e-03
Leishmania phagocytosis 56 8.66e-04 -2.57e-01 3.77e-03
Parasite infection 56 8.66e-04 -2.57e-01 3.77e-03
Interferon Signaling 174 4.91e-09 -2.57e-01 1.22e-07
TP53 Regulates Transcription of DNA Repair Genes 61 5.38e-04 -2.56e-01 2.50e-03
Diseases associated with glycosaminoglycan metabolism 36 7.88e-03 2.56e-01 2.57e-02
Selective autophagy 58 7.53e-04 -2.56e-01 3.38e-03
S33 mutants of beta-catenin aren’t phosphorylated 15 8.64e-02 -2.56e-01 1.87e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 8.64e-02 -2.56e-01 1.87e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 8.64e-02 -2.56e-01 1.87e-01
Signaling by CTNNB1 phospho-site mutants 15 8.64e-02 -2.56e-01 1.87e-01
Signaling by GSK3beta mutants 15 8.64e-02 -2.56e-01 1.87e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 8.64e-02 -2.56e-01 1.87e-01
Negative epigenetic regulation of rRNA expression 70 2.20e-04 -2.55e-01 1.19e-03
RHO GTPases activate CIT 19 5.53e-02 -2.54e-01 1.30e-01
Ephrin signaling 19 5.53e-02 -2.54e-01 1.30e-01
O-glycosylation of TSR domain-containing proteins 38 6.99e-03 2.53e-01 2.32e-02
CD209 (DC-SIGN) signaling 19 5.66e-02 -2.53e-01 1.32e-01
MyD88-independent TLR4 cascade 94 2.30e-05 -2.53e-01 1.69e-04
TRIF(TICAM1)-mediated TLR4 signaling 94 2.30e-05 -2.53e-01 1.69e-04
Gap junction assembly 10 1.67e-01 2.52e-01 3.01e-01
Erythropoietin activates RAS 13 1.15e-01 -2.52e-01 2.28e-01
Potential therapeutics for SARS 81 8.72e-05 -2.52e-01 5.30e-04
Regulation of RUNX1 Expression and Activity 18 6.62e-02 -2.50e-01 1.51e-01
Synthesis of PIPs at the Golgi membrane 15 9.36e-02 -2.50e-01 1.98e-01
Signaling by FGFR2 68 3.71e-04 -2.50e-01 1.86e-03
Formation of Incision Complex in GG-NER 43 4.72e-03 -2.49e-01 1.66e-02
HCMV Infection 104 1.14e-05 -2.49e-01 8.90e-05
Toll Like Receptor 9 (TLR9) Cascade 91 4.28e-05 -2.48e-01 2.79e-04
COPI-mediated anterograde transport 79 1.40e-04 -2.48e-01 7.95e-04
Resolution of D-Loop Structures 33 1.41e-02 2.47e-01 4.22e-02
Amine ligand-binding receptors 22 4.52e-02 2.47e-01 1.10e-01
Regulation of innate immune responses to cytosolic DNA 14 1.10e-01 -2.47e-01 2.22e-01
Signaling by WNT in cancer 33 1.42e-02 -2.46e-01 4.25e-02
TNF signaling 44 4.68e-03 -2.46e-01 1.65e-02
Mitotic Telophase/Cytokinesis 13 1.25e-01 -2.46e-01 2.42e-01
RNA Polymerase I Transcription Termination 30 2.01e-02 -2.45e-01 5.73e-02
VLDLR internalisation and degradation 11 1.59e-01 2.45e-01 2.94e-01
Interleukin-17 signaling 68 4.73e-04 -2.45e-01 2.27e-03
MyD88 dependent cascade initiated on endosome 87 7.91e-05 -2.45e-01 4.85e-04
Toll Like Receptor 7/8 (TLR7/8) Cascade 87 7.91e-05 -2.45e-01 4.85e-04
XBP1(S) activates chaperone genes 48 3.38e-03 -2.44e-01 1.24e-02
EGFR downregulation 29 2.30e-02 -2.44e-01 6.43e-02
Condensation of Prophase Chromosomes 34 1.38e-02 -2.44e-01 4.16e-02
Presynaptic function of Kainate receptors 17 8.25e-02 -2.43e-01 1.81e-01
Formation of apoptosome 11 1.63e-01 -2.43e-01 2.98e-01
Regulation of the apoptosome activity 11 1.63e-01 -2.43e-01 2.98e-01
Association of TriC/CCT with target proteins during biosynthesis 37 1.05e-02 -2.43e-01 3.29e-02
Regulation of KIT signaling 15 1.03e-01 -2.43e-01 2.10e-01
Epigenetic regulation of gene expression 109 1.19e-05 -2.43e-01 9.20e-05
Cyclin A:Cdk2-associated events at S phase entry 85 1.10e-04 -2.43e-01 6.50e-04
Cellular responses to stress 674 6.61e-27 -2.42e-01 3.24e-24
Thrombin signalling through proteinase activated receptors (PARs) 27 2.97e-02 -2.42e-01 7.81e-02
Rab regulation of trafficking 120 4.78e-06 -2.42e-01 4.02e-05
Negative regulation of FLT3 14 1.17e-01 -2.42e-01 2.31e-01
Polymerase switching on the C-strand of the telomere 26 3.31e-02 2.41e-01 8.56e-02
NoRC negatively regulates rRNA expression 67 6.33e-04 -2.41e-01 2.87e-03
Gene Silencing by RNA 97 4.04e-05 -2.41e-01 2.67e-04
Mitotic Prophase 103 2.36e-05 -2.41e-01 1.71e-04
SUMOylation of chromatin organization proteins 57 1.66e-03 -2.41e-01 6.71e-03
Processing of Intronless Pre-mRNAs 19 6.97e-02 -2.40e-01 1.57e-01
Cellular response to chemical stress 147 5.35e-07 -2.39e-01 6.16e-06
Signaling by FGFR4 in disease 11 1.69e-01 -2.39e-01 3.03e-01
Regulation of signaling by CBL 18 7.88e-02 -2.39e-01 1.74e-01
RNA Polymerase I Promoter Opening 24 4.35e-02 -2.38e-01 1.07e-01
FGFR2c ligand binding and activation 10 1.93e-01 2.38e-01 3.32e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 3.61e-02 2.37e-01 9.19e-02
Platelet calcium homeostasis 24 4.42e-02 2.37e-01 1.08e-01
RHO GTPases Activate WASPs and WAVEs 36 1.39e-02 -2.37e-01 4.17e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 86 1.46e-04 -2.37e-01 8.22e-04
BMAL1:CLOCK,NPAS2 activates circadian gene expression 26 3.70e-02 -2.36e-01 9.40e-02
Heme signaling 42 8.39e-03 -2.35e-01 2.71e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 31 2.39e-02 -2.34e-01 6.63e-02
Nuclear Envelope Breakdown 53 3.18e-03 -2.34e-01 1.17e-02
Orc1 removal from chromatin 69 7.79e-04 -2.34e-01 3.47e-03
Activation of the pre-replicative complex 33 2.04e-02 2.33e-01 5.80e-02
HDR through MMEJ (alt-NHEJ) 10 2.02e-01 2.33e-01 3.41e-01
tRNA processing in the nucleus 59 1.96e-03 -2.33e-01 7.71e-03
Cellular responses to stimuli 683 2.29e-25 -2.33e-01 5.63e-23
Activation of ATR in response to replication stress 37 1.49e-02 2.31e-01 4.43e-02
Signaling by ALK fusions and activated point mutants 55 3.02e-03 -2.31e-01 1.12e-02
Signaling by ALK in cancer 55 3.02e-03 -2.31e-01 1.12e-02
HSF1 activation 26 4.14e-02 -2.31e-01 1.02e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 3.95e-03 -2.31e-01 1.42e-02
Interaction between L1 and Ankyrins 25 4.56e-02 2.31e-01 1.11e-01
Antigen processing: Ubiquitination & Proteasome degradation 292 1.09e-11 -2.31e-01 4.01e-10
Cyclin E associated events during G1/S transition 83 2.80e-04 -2.31e-01 1.47e-03
Signaling by the B Cell Receptor (BCR) 106 4.08e-05 -2.31e-01 2.68e-04
Defective GALNT12 causes CRCS1 10 2.08e-01 2.30e-01 3.46e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 33 2.26e-02 -2.29e-01 6.36e-02
FGFR4 ligand binding and activation 10 2.12e-01 2.28e-01 3.52e-01
Negative regulation of FGFR3 signaling 27 4.05e-02 -2.28e-01 1.00e-01
EPHA-mediated growth cone collapse 15 1.28e-01 -2.27e-01 2.45e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 2.62e-02 2.27e-01 7.05e-02
Constitutive Signaling by AKT1 E17K in Cancer 26 4.57e-02 -2.26e-01 1.11e-01
Transcriptional regulation by RUNX2 115 2.84e-05 -2.26e-01 2.02e-04
Tie2 Signaling 17 1.07e-01 -2.25e-01 2.18e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 9.84e-02 -2.25e-01 2.03e-01
Neddylation 222 8.54e-09 -2.24e-01 1.96e-07
IKK complex recruitment mediated by RIP1 22 6.91e-02 -2.24e-01 1.57e-01
G beta:gamma signalling through CDC42 16 1.21e-01 -2.24e-01 2.37e-01
Dopamine Neurotransmitter Release Cycle 22 6.95e-02 -2.24e-01 1.57e-01
Nephrin family interactions 20 8.40e-02 -2.23e-01 1.83e-01
COPI-dependent Golgi-to-ER retrograde traffic 79 6.17e-04 -2.23e-01 2.80e-03
APC-Cdc20 mediated degradation of Nek2A 26 4.97e-02 -2.22e-01 1.19e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 9.38e-02 -2.22e-01 1.98e-01
GAB1 signalosome 15 1.37e-01 -2.22e-01 2.61e-01
Negative regulation of FGFR4 signaling 27 4.63e-02 -2.22e-01 1.12e-01
Activated point mutants of FGFR2 13 1.67e-01 2.21e-01 3.01e-01
TICAM1-dependent activation of IRF3/IRF7 12 1.84e-01 -2.21e-01 3.22e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.60e-02 -2.21e-01 1.30e-01
Phase 2 - plateau phase 13 1.69e-01 2.20e-01 3.03e-01
Synaptic adhesion-like molecules 21 8.06e-02 -2.20e-01 1.78e-01
Regulation of gene expression in beta cells 13 1.70e-01 2.20e-01 3.03e-01
SUMOylation of transcription cofactors 44 1.17e-02 -2.20e-01 3.59e-02
ESR-mediated signaling 171 7.09e-07 -2.20e-01 7.73e-06
Inactivation of CSF3 (G-CSF) signaling 25 5.75e-02 -2.19e-01 1.33e-01
Zinc transporters 14 1.55e-01 -2.19e-01 2.89e-01
Synthesis of PA 32 3.18e-02 -2.19e-01 8.31e-02
p38MAPK events 13 1.72e-01 -2.19e-01 3.06e-01
Mitochondrial biogenesis 91 3.04e-04 -2.19e-01 1.55e-03
Syndecan interactions 19 9.91e-02 2.19e-01 2.05e-01
RNA Polymerase I Promoter Escape 52 6.45e-03 -2.18e-01 2.19e-02
Thromboxane signalling through TP receptor 20 9.13e-02 -2.18e-01 1.94e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 51 7.12e-03 -2.18e-01 2.35e-02
Activation of the AP-1 family of transcription factors 10 2.33e-01 -2.18e-01 3.82e-01
RAF activation 34 2.82e-02 -2.17e-01 7.47e-02
Golgi-to-ER retrograde transport 112 7.19e-05 -2.17e-01 4.51e-04
Interleukin-35 Signalling 12 1.94e-01 -2.17e-01 3.32e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 9.37e-04 -2.17e-01 4.01e-03
Nicotinate metabolism 29 4.36e-02 2.17e-01 1.07e-01
Signaling by KIT in disease 19 1.02e-01 -2.16e-01 2.10e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 1.02e-01 -2.16e-01 2.10e-01
Interferon gamma signaling 79 8.89e-04 -2.16e-01 3.85e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 1.78e-01 2.16e-01 3.14e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.50e-02 -2.16e-01 6.82e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 13 1.78e-01 -2.16e-01 3.14e-01
Signaling by FLT3 ITD and TKD mutants 16 1.36e-01 -2.16e-01 2.58e-01
Cytochrome c-mediated apoptotic response 13 1.79e-01 -2.15e-01 3.15e-01
Fcgamma receptor (FCGR) dependent phagocytosis 82 7.49e-04 -2.15e-01 3.37e-03
Assembly of the pre-replicative complex 90 4.17e-04 -2.15e-01 2.03e-03
Regulation of localization of FOXO transcription factors 12 1.98e-01 2.15e-01 3.35e-01
Regulation of TNFR1 signaling 35 2.80e-02 -2.15e-01 7.43e-02
Oncogene Induced Senescence 31 3.86e-02 -2.15e-01 9.71e-02
Switching of origins to a post-replicative state 89 4.74e-04 -2.14e-01 2.27e-03
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 11 2.20e-01 2.14e-01 3.63e-01
SUMOylation of DNA damage response and repair proteins 76 1.28e-03 -2.14e-01 5.33e-03
G beta:gamma signalling through PLC beta 16 1.41e-01 -2.13e-01 2.65e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 7.15e-02 -2.12e-01 1.60e-01
Disorders of transmembrane transporters 154 5.66e-06 -2.12e-01 4.71e-05
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 6.58e-03 -2.12e-01 2.21e-02
Infectious disease 735 1.07e-22 -2.12e-01 1.75e-20
Signaling by FGFR3 38 2.39e-02 -2.12e-01 6.63e-02
Hedgehog ‘off’ state 95 3.61e-04 -2.12e-01 1.82e-03
FGFR3 mutant receptor activation 10 2.47e-01 2.11e-01 4.00e-01
Signaling by activated point mutants of FGFR3 10 2.47e-01 2.11e-01 4.00e-01
Separation of Sister Chromatids 168 2.42e-06 -2.11e-01 2.24e-05
Pre-NOTCH Processing in Golgi 18 1.22e-01 -2.10e-01 2.39e-01
Intraflagellar transport 39 2.31e-02 2.10e-01 6.45e-02
Estrogen-dependent gene expression 108 1.62e-04 -2.10e-01 9.06e-04
Metalloprotease DUBs 24 7.65e-02 -2.09e-01 1.71e-01
NCAM1 interactions 35 3.26e-02 2.09e-01 8.45e-02
PCNA-Dependent Long Patch Base Excision Repair 21 9.80e-02 2.09e-01 2.03e-01
Regulation of TP53 Activity through Methylation 19 1.16e-01 -2.08e-01 2.29e-01
MAPK3 (ERK1) activation 10 2.55e-01 -2.08e-01 4.08e-01
Antigen processing-Cross presentation 96 4.37e-04 -2.08e-01 2.12e-03
Integrin cell surface interactions 58 6.47e-03 2.07e-01 2.19e-02
Cell-cell junction organization 51 1.08e-02 2.06e-01 3.38e-02
PRC2 methylates histones and DNA 34 3.73e-02 -2.06e-01 9.45e-02
Diseases of DNA repair 34 3.76e-02 2.06e-01 9.51e-02
PIP3 activates AKT signaling 252 1.78e-08 -2.06e-01 3.80e-07
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 95 5.28e-04 -2.06e-01 2.46e-03
Toll Like Receptor 2 (TLR2) Cascade 95 5.28e-04 -2.06e-01 2.46e-03
Toll Like Receptor TLR1:TLR2 Cascade 95 5.28e-04 -2.06e-01 2.46e-03
Toll Like Receptor TLR6:TLR2 Cascade 95 5.28e-04 -2.06e-01 2.46e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 26 6.96e-02 -2.06e-01 1.57e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 56 7.88e-03 -2.05e-01 2.57e-02
Dual incision in TC-NER 65 4.23e-03 -2.05e-01 1.50e-02
Synthesis of IP2, IP, and Ins in the cytosol 14 1.85e-01 -2.05e-01 3.23e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 5.31e-02 -2.04e-01 1.26e-01
DNA Double Strand Break Response 52 1.11e-02 -2.04e-01 3.45e-02
Plasma lipoprotein clearance 29 5.84e-02 2.03e-01 1.35e-01
RAB GEFs exchange GTP for GDP on RABs 88 1.01e-03 -2.03e-01 4.31e-03
Metabolism of cofactors 19 1.26e-01 2.02e-01 2.43e-01
Non-integrin membrane-ECM interactions 41 2.50e-02 2.02e-01 6.82e-02
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.38e-01 2.02e-01 2.61e-01
COPI-independent Golgi-to-ER retrograde traffic 33 4.45e-02 -2.02e-01 1.09e-01
Signaling by NTRK1 (TRKA) 113 2.13e-04 -2.02e-01 1.16e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 1.02e-01 2.01e-01 2.10e-01
RIP-mediated NFkB activation via ZBP1 16 1.64e-01 -2.01e-01 2.99e-01
Activation of Matrix Metalloproteinases 27 7.09e-02 -2.01e-01 1.59e-01
activated TAK1 mediates p38 MAPK activation 19 1.30e-01 -2.01e-01 2.49e-01
Transcriptional regulation by RUNX1 184 2.72e-06 -2.00e-01 2.48e-05
FGFRL1 modulation of FGFR1 signaling 11 2.50e-01 2.00e-01 4.03e-01
Signaling by NTRKs 131 7.67e-05 -2.00e-01 4.74e-04
Synthesis, secretion, and deacylation of Ghrelin 14 1.95e-01 2.00e-01 3.33e-01
Assembly of the ORC complex at the origin of replication 30 5.87e-02 -1.99e-01 1.36e-01
tRNA Aminoacylation 42 2.55e-02 -1.99e-01 6.93e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 50 1.48e-02 -1.99e-01 4.41e-02
Toll Like Receptor 4 (TLR4) Cascade 123 1.36e-04 -1.99e-01 7.76e-04
G beta:gamma signalling through BTK 14 1.97e-01 -1.99e-01 3.35e-01
Beta-catenin independent WNT signaling 140 4.76e-05 -1.99e-01 3.09e-04
Mitochondrial protein import 64 5.96e-03 -1.99e-01 2.05e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 2.77e-01 1.98e-01 4.32e-01
Formation of the cornified envelope 29 6.47e-02 -1.98e-01 1.49e-01
Senescence-Associated Secretory Phenotype (SASP) 71 3.90e-03 -1.98e-01 1.40e-02
Signaling by FGFR 81 2.10e-03 -1.98e-01 8.18e-03
ADP signalling through P2Y purinoceptor 12 17 1.58e-01 -1.98e-01 2.93e-01
Receptor-type tyrosine-protein phosphatases 18 1.47e-01 -1.98e-01 2.74e-01
Telomere C-strand (Lagging Strand) Synthesis 34 4.63e-02 1.97e-01 1.12e-01
Signaling by Erythropoietin 24 9.50e-02 -1.97e-01 1.99e-01
Signaling by PDGFR in disease 19 1.38e-01 -1.96e-01 2.62e-01
Gluconeogenesis 29 6.74e-02 1.96e-01 1.54e-01
Retrograde neurotrophin signalling 14 2.04e-01 1.96e-01 3.42e-01
Interleukin-20 family signaling 19 1.39e-01 -1.96e-01 2.63e-01
Homologous DNA Pairing and Strand Exchange 42 2.81e-02 1.96e-01 7.45e-02
Extra-nuclear estrogen signaling 66 5.94e-03 -1.96e-01 2.05e-02
Surfactant metabolism 19 1.40e-01 -1.95e-01 2.64e-01
Cleavage of the damaged pyrimidine 33 5.22e-02 -1.95e-01 1.24e-01
Depyrimidination 33 5.22e-02 -1.95e-01 1.24e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 33 5.22e-02 -1.95e-01 1.24e-01
Class I MHC mediated antigen processing & presentation 352 2.93e-10 -1.95e-01 8.30e-09
Mitotic Metaphase and Anaphase 229 4.18e-07 -1.94e-01 5.09e-06
ATF6 (ATF6-alpha) activates chaperones 12 2.45e-01 -1.94e-01 3.97e-01
DAP12 interactions 33 5.40e-02 -1.94e-01 1.27e-01
Acetylcholine binding and downstream events 11 2.67e-01 1.93e-01 4.19e-01
Postsynaptic nicotinic acetylcholine receptors 11 2.67e-01 1.93e-01 4.19e-01
Diseases of glycosylation 131 1.33e-04 1.93e-01 7.63e-04
LDL clearance 16 1.81e-01 1.93e-01 3.17e-01
RHO GTPases activate PKNs 52 1.60e-02 -1.93e-01 4.66e-02
GRB2 events in ERBB2 signaling 15 1.96e-01 -1.93e-01 3.33e-01
Regulation of actin dynamics for phagocytic cup formation 58 1.11e-02 -1.93e-01 3.45e-02
Mitotic Anaphase 228 5.34e-07 -1.93e-01 6.16e-06
Regulation of PTEN gene transcription 61 9.33e-03 -1.92e-01 2.98e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.70e-01 1.92e-01 3.03e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.70e-01 1.92e-01 3.03e-01
Nucleotide Excision Repair 110 4.91e-04 -1.92e-01 2.34e-03
Gene expression (Transcription) 1375 5.17e-33 -1.91e-01 3.81e-30
DSCAM interactions 10 2.96e-01 -1.91e-01 4.57e-01
Cohesin Loading onto Chromatin 10 2.96e-01 -1.91e-01 4.57e-01
TCF dependent signaling in response to WNT 187 6.88e-06 -1.91e-01 5.57e-05
B-WICH complex positively regulates rRNA expression 52 1.76e-02 -1.90e-01 5.06e-02
Glycosaminoglycan metabolism 110 5.68e-04 1.90e-01 2.62e-03
Integrin signaling 24 1.07e-01 -1.90e-01 2.17e-01
G-protein activation 18 1.63e-01 -1.90e-01 2.98e-01
Uptake and function of anthrax toxins 11 2.75e-01 -1.90e-01 4.29e-01
Signaling by NOTCH4 81 3.13e-03 -1.90e-01 1.16e-02
Signaling by FGFR4 37 4.57e-02 -1.90e-01 1.11e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 25 1.01e-01 -1.90e-01 2.08e-01
Autophagy 125 2.50e-04 -1.90e-01 1.33e-03
Presynaptic phase of homologous DNA pairing and strand exchange 39 4.05e-02 1.90e-01 1.00e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.06e-01 -1.88e-01 3.45e-01
Plasma lipoprotein assembly 13 2.40e-01 1.88e-01 3.91e-01
Sialic acid metabolism 31 6.99e-02 -1.88e-01 1.57e-01
Assembly and cell surface presentation of NMDA receptors 24 1.11e-01 -1.88e-01 2.23e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.47e-01 -1.87e-01 2.74e-01
ZBP1(DAI) mediated induction of type I IFNs 19 1.58e-01 -1.87e-01 2.92e-01
Early Phase of HIV Life Cycle 13 2.43e-01 -1.87e-01 3.95e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.96e-01 -1.87e-01 3.34e-01
CD28 co-stimulation 29 8.27e-02 -1.86e-01 1.81e-01
Blood group systems biosynthesis 19 1.61e-01 -1.86e-01 2.96e-01
Aflatoxin activation and detoxification 14 2.29e-01 1.86e-01 3.77e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 24 1.16e-01 1.85e-01 2.28e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 24 1.16e-01 1.85e-01 2.28e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 1.16e-01 1.85e-01 2.28e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 1.16e-01 1.85e-01 2.28e-01
Diseases of DNA Double-Strand Break Repair 24 1.16e-01 1.85e-01 2.28e-01
FLT3 Signaling 36 5.50e-02 -1.85e-01 1.29e-01
FCERI mediated MAPK activation 29 8.56e-02 -1.84e-01 1.86e-01
Defective C1GALT1C1 causes TNPS 11 2.90e-01 1.84e-01 4.49e-01
Translocation of ZAP-70 to Immunological synapse 14 2.33e-01 1.84e-01 3.82e-01
Protein folding 89 2.74e-03 -1.84e-01 1.03e-02
Glyoxylate metabolism and glycine degradation 26 1.06e-01 -1.83e-01 2.15e-01
HDR through Homologous Recombination (HRR) 66 1.02e-02 1.83e-01 3.22e-02
Signaling by CSF3 (G-CSF) 30 8.35e-02 -1.83e-01 1.83e-01
Diseases of metabolism 215 4.13e-06 1.82e-01 3.51e-05
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.19e-02 -1.82e-01 3.66e-02
Cleavage of the damaged purine 28 9.65e-02 -1.81e-01 2.01e-01
Depurination 28 9.65e-02 -1.81e-01 2.01e-01
Recognition and association of DNA glycosylase with site containing an affected purine 28 9.65e-02 -1.81e-01 2.01e-01
SIRT1 negatively regulates rRNA expression 29 9.10e-02 -1.81e-01 1.94e-01
Regulation of beta-cell development 29 9.27e-02 1.80e-01 1.96e-01
Intracellular signaling by second messengers 289 1.31e-07 -1.80e-01 2.10e-06
Nuclear Envelope (NE) Reassembly 73 7.77e-03 -1.80e-01 2.55e-02
Mitochondrial Fatty Acid Beta-Oxidation 35 6.52e-02 1.80e-01 1.50e-01
Processing of SMDT1 15 2.27e-01 -1.80e-01 3.74e-01
Methylation 14 2.45e-01 -1.80e-01 3.97e-01
Negative regulation of FGFR2 signaling 30 8.88e-02 -1.79e-01 1.90e-01
Regulation of TP53 Activity 155 1.14e-04 -1.79e-01 6.70e-04
Phosphorylation of the APC/C 20 1.65e-01 -1.79e-01 3.00e-01
Signaling by Nuclear Receptors 238 1.90e-06 -1.79e-01 1.81e-05
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 1.66e-01 -1.79e-01 3.01e-01
Toll-like Receptor Cascades 141 2.45e-04 -1.79e-01 1.31e-03
Norepinephrine Neurotransmitter Release Cycle 16 2.20e-01 -1.77e-01 3.63e-01
RNA Polymerase II Transcription 1239 6.19e-26 -1.77e-01 1.82e-23
FGFR2 ligand binding and activation 15 2.35e-01 1.77e-01 3.85e-01
Signaling by FGFR2 in disease 39 5.59e-02 -1.77e-01 1.30e-01
RMTs methylate histone arginines 42 4.80e-02 -1.76e-01 1.15e-01
G2/M Transition 181 4.27e-05 -1.76e-01 2.79e-04
Transcriptional Regulation by TP53 356 1.07e-08 -1.76e-01 2.39e-07
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 26 1.20e-01 -1.76e-01 2.35e-01
Activation of HOX genes during differentiation 81 6.22e-03 -1.76e-01 2.12e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 81 6.22e-03 -1.76e-01 2.12e-02
PIWI-interacting RNA (piRNA) biogenesis 26 1.21e-01 -1.76e-01 2.36e-01
Pyrimidine salvage 10 3.36e-01 1.76e-01 4.93e-01
Beta-oxidation of very long chain fatty acids 10 3.37e-01 1.75e-01 4.93e-01
Signaling by EGFR in Cancer 23 1.46e-01 -1.75e-01 2.72e-01
Presynaptic depolarization and calcium channel opening 11 3.14e-01 1.75e-01 4.76e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.30e-01 1.75e-01 2.49e-01
Class I peroxisomal membrane protein import 19 1.87e-01 1.75e-01 3.25e-01
Initiation of Nuclear Envelope (NE) Reformation 19 1.88e-01 -1.75e-01 3.26e-01
tRNA processing in the mitochondrion 20 1.78e-01 1.74e-01 3.14e-01
Binding and Uptake of Ligands by Scavenger Receptors 32 9.04e-02 1.73e-01 1.93e-01
RORA activates gene expression 18 2.04e-01 -1.73e-01 3.42e-01
Cytokine Signaling in Immune system 605 3.79e-13 -1.72e-01 1.99e-11
SARS-CoV Infections 150 2.67e-04 -1.72e-01 1.41e-03
O-linked glycosylation 97 3.41e-03 1.72e-01 1.24e-02
Signalling to ERKs 33 8.77e-02 -1.72e-01 1.88e-01
Free fatty acids regulate insulin secretion 10 3.49e-01 -1.71e-01 5.02e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 12 3.05e-01 -1.71e-01 4.66e-01
Defective Intrinsic Pathway for Apoptosis 22 1.65e-01 -1.71e-01 3.00e-01
Apoptotic cleavage of cellular proteins 35 8.07e-02 1.71e-01 1.78e-01
DNA Damage/Telomere Stress Induced Senescence 51 3.53e-02 -1.70e-01 9.06e-02
Mitotic G2-G2/M phases 183 7.08e-05 -1.70e-01 4.48e-04
Frs2-mediated activation 12 3.08e-01 -1.70e-01 4.69e-01
Resolution of Abasic Sites (AP sites) 38 6.98e-02 1.70e-01 1.57e-01
Chaperonin-mediated protein folding 83 7.62e-03 -1.69e-01 2.51e-02
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.81e-01 -1.69e-01 3.17e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.81e-01 -1.69e-01 3.17e-01
Nucleotide salvage 21 1.81e-01 1.69e-01 3.17e-01
Signaling by WNT 280 1.25e-06 -1.68e-01 1.25e-05
ER to Golgi Anterograde Transport 131 9.11e-04 -1.68e-01 3.91e-03
RAF-independent MAPK1/3 activation 23 1.64e-01 -1.68e-01 2.99e-01
Generic Transcription Pathway 1121 2.98e-21 -1.67e-01 3.99e-19
Diseases of signal transduction by growth factor receptors and second messengers 407 7.54e-09 -1.67e-01 1.76e-07
Transport to the Golgi and subsequent modification 161 2.67e-04 -1.66e-01 1.41e-03
Oxidative Stress Induced Senescence 82 9.27e-03 -1.66e-01 2.97e-02
PI Metabolism 77 1.17e-02 -1.66e-01 3.61e-02
Clathrin-mediated endocytosis 135 8.80e-04 -1.66e-01 3.82e-03
Mitochondrial calcium ion transport 22 1.79e-01 -1.66e-01 3.15e-01
Interleukin-27 signaling 10 3.65e-01 -1.65e-01 5.19e-01
TRAF6 mediated IRF7 activation 16 2.52e-01 -1.65e-01 4.06e-01
Calnexin/calreticulin cycle 26 1.45e-01 -1.65e-01 2.72e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 180 1.37e-04 -1.65e-01 7.76e-04
Signaling by NTRK2 (TRKB) 24 1.63e-01 -1.65e-01 2.98e-01
Signaling by NTRK3 (TRKC) 16 2.57e-01 -1.64e-01 4.10e-01
Signaling by FGFR3 fusions in cancer 10 3.71e-01 -1.63e-01 5.26e-01
Endosomal/Vacuolar pathway 12 3.27e-01 -1.63e-01 4.85e-01
Post-translational modification: synthesis of GPI-anchored proteins 65 2.28e-02 1.63e-01 6.40e-02
Pyruvate metabolism 28 1.36e-01 -1.63e-01 2.60e-01
Glycogen storage diseases 14 2.94e-01 1.62e-01 4.55e-01
Platelet Aggregation (Plug Formation) 29 1.32e-01 -1.62e-01 2.52e-01
Cellular Senescence 152 5.80e-04 -1.62e-01 2.66e-03
Collagen formation 84 1.10e-02 1.60e-01 3.43e-02
Signaling by FGFR in disease 59 3.31e-02 -1.60e-01 8.56e-02
Purine catabolism 17 2.53e-01 1.60e-01 4.06e-01
ABC-family proteins mediated transport 97 6.43e-03 -1.60e-01 2.18e-02
Regulation of TLR by endogenous ligand 14 3.00e-01 1.60e-01 4.63e-01
SLC transporter disorders 81 1.29e-02 -1.60e-01 3.91e-02
Glutathione synthesis and recycling 12 3.39e-01 1.59e-01 4.95e-01
Signaling by Hippo 20 2.18e-01 -1.59e-01 3.61e-01
Glycolysis 67 2.50e-02 -1.58e-01 6.82e-02
IL-6-type cytokine receptor ligand interactions 16 2.73e-01 1.58e-01 4.28e-01
Mitochondrial translation elongation 90 1.00e-02 -1.57e-01 3.18e-02
Attenuation phase 23 1.93e-01 -1.57e-01 3.32e-01
SHC1 events in EGFR signaling 12 3.48e-01 -1.56e-01 5.02e-01
MET activates PTK2 signaling 18 2.51e-01 1.56e-01 4.04e-01
Mitochondrial translation initiation 90 1.10e-02 -1.55e-01 3.42e-02
Respiratory electron transport 103 6.51e-03 -1.55e-01 2.20e-02
Signaling by FGFR1 in disease 36 1.08e-01 -1.55e-01 2.18e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 3.96e-01 1.55e-01 5.49e-01
Dectin-2 family 14 3.17e-01 1.55e-01 4.78e-01
CaMK IV-mediated phosphorylation of CREB 10 3.99e-01 -1.54e-01 5.52e-01
Base-Excision Repair, AP Site Formation 35 1.15e-01 -1.54e-01 2.28e-01
Signaling by Hedgehog 132 2.33e-03 -1.53e-01 8.99e-03
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 27 1.68e-01 -1.53e-01 3.03e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 3.21e-01 -1.53e-01 4.81e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.17e-01 -1.53e-01 2.30e-01
Post-translational protein phosphorylation 87 1.36e-02 1.53e-01 4.09e-02
Scavenging by Class A Receptors 17 2.75e-01 1.53e-01 4.30e-01
Signaling by SCF-KIT 41 9.10e-02 -1.53e-01 1.94e-01
Phospholipase C-mediated cascade; FGFR2 14 3.26e-01 1.51e-01 4.85e-01
RHO GTPases Activate ROCKs 19 2.53e-01 -1.51e-01 4.06e-01
Signaling by NOTCH 193 2.87e-04 -1.51e-01 1.49e-03
Prolonged ERK activation events 14 3.29e-01 -1.51e-01 4.85e-01
Disorders of Developmental Biology 13 3.47e-01 1.51e-01 5.01e-01
Disorders of Nervous System Development 13 3.47e-01 1.51e-01 5.01e-01
Loss of function of MECP2 in Rett syndrome 13 3.47e-01 1.51e-01 5.01e-01
Pervasive developmental disorders 13 3.47e-01 1.51e-01 5.01e-01
Collagen biosynthesis and modifying enzymes 62 4.03e-02 1.51e-01 1.00e-01
G2/M Checkpoints 140 2.13e-03 -1.50e-01 8.27e-03
Signaling by Interleukins 389 3.83e-07 -1.50e-01 4.74e-06
Membrane Trafficking 579 6.81e-10 -1.50e-01 1.82e-08
Sodium/Calcium exchangers 11 3.91e-01 1.49e-01 5.45e-01
Translesion Synthesis by POLH 18 2.73e-01 -1.49e-01 4.28e-01
PI3K events in ERBB2 signaling 15 3.17e-01 -1.49e-01 4.78e-01
RAB geranylgeranylation 62 4.22e-02 -1.49e-01 1.04e-01
Signaling by FGFR1 47 7.69e-02 -1.49e-01 1.71e-01
M Phase 370 8.69e-07 -1.49e-01 9.27e-06
PKA activation 16 3.04e-01 1.48e-01 4.66e-01
Phase 0 - rapid depolarisation 29 1.67e-01 1.48e-01 3.01e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 1.60e-01 -1.48e-01 2.95e-01
Heme degradation 11 3.98e-01 -1.47e-01 5.50e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.97e-02 -1.47e-01 5.63e-02
The citric acid (TCA) cycle and respiratory electron transport 173 8.42e-04 -1.47e-01 3.71e-03
Assembly of collagen fibrils and other multimeric structures 52 6.75e-02 1.47e-01 1.54e-01
TRAF3-dependent IRF activation pathway 14 3.43e-01 -1.46e-01 4.98e-01
Pexophagy 11 4.01e-01 -1.46e-01 5.53e-01
DNA methylation 26 1.97e-01 -1.46e-01 3.35e-01
Transcriptional Regulation by VENTX 38 1.19e-01 -1.46e-01 2.34e-01
Negative regulation of MAPK pathway 43 9.78e-02 -1.46e-01 2.03e-01
Activation of BAD and translocation to mitochondria 15 3.28e-01 -1.46e-01 4.85e-01
SHC1 events in ERBB4 signaling 13 3.64e-01 -1.45e-01 5.19e-01
Incretin synthesis, secretion, and inactivation 16 3.14e-01 -1.45e-01 4.76e-01
Mitochondrial translation termination 90 1.73e-02 -1.45e-01 5.02e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 2.74e-01 -1.45e-01 4.28e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 2.74e-01 -1.45e-01 4.28e-01
Signaling by Retinoic Acid 38 1.23e-01 -1.45e-01 2.39e-01
Macroautophagy 112 8.23e-03 -1.44e-01 2.68e-02
RIPK1-mediated regulated necrosis 27 1.95e-01 -1.44e-01 3.33e-01
Regulation of necroptotic cell death 27 1.95e-01 -1.44e-01 3.33e-01
Synthesis of substrates in N-glycan biosythesis 61 5.20e-02 -1.44e-01 1.24e-01
DAP12 signaling 26 2.05e-01 -1.44e-01 3.43e-01
FRS-mediated FGFR1 signaling 20 2.67e-01 -1.43e-01 4.19e-01
Phospholipid metabolism 186 7.66e-04 -1.43e-01 3.43e-03
SUMO E3 ligases SUMOylate target proteins 164 1.59e-03 -1.43e-01 6.48e-03
Deactivation of the beta-catenin transactivating complex 41 1.14e-01 1.43e-01 2.27e-01
Phosphorylation of CD3 and TCR zeta chains 17 3.09e-01 1.43e-01 4.69e-01
Mitochondrial translation 96 1.58e-02 -1.42e-01 4.62e-02
DNA Replication Pre-Initiation 107 1.14e-02 -1.42e-01 3.53e-02
O-linked glycosylation of mucins 49 8.70e-02 1.41e-01 1.87e-01
Cell Cycle Checkpoints 260 9.10e-05 -1.41e-01 5.51e-04
Ion homeostasis 46 9.84e-02 1.41e-01 2.03e-01
Metabolism of amino acids and derivatives 339 8.34e-06 -1.41e-01 6.60e-05
Synthesis of very long-chain fatty acyl-CoAs 22 2.54e-01 1.40e-01 4.07e-01
Metabolism of proteins 1739 1.24e-22 -1.40e-01 1.83e-20
Caspase-mediated cleavage of cytoskeletal proteins 12 4.01e-01 1.40e-01 5.53e-01
NR1H2 and NR1H3-mediated signaling 43 1.12e-01 -1.40e-01 2.26e-01
RHOBTB3 ATPase cycle 10 4.45e-01 -1.40e-01 5.96e-01
Sphingolipid de novo biosynthesis 43 1.14e-01 -1.39e-01 2.27e-01
Ion transport by P-type ATPases 48 9.49e-02 1.39e-01 1.99e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 3.35e-01 -1.39e-01 4.93e-01
SUMOylation 170 1.73e-03 -1.39e-01 6.97e-03
Serotonin Neurotransmitter Release Cycle 17 3.21e-01 -1.39e-01 4.81e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 13 3.86e-01 1.39e-01 5.40e-01
Phospholipase C-mediated cascade; FGFR4 11 4.26e-01 1.38e-01 5.82e-01
InlB-mediated entry of Listeria monocytogenes into host cell 15 3.55e-01 -1.38e-01 5.09e-01
Regulation of Complement cascade 25 2.33e-01 -1.38e-01 3.82e-01
Activation of kainate receptors upon glutamate binding 26 2.25e-01 -1.37e-01 3.71e-01
Physiological factors 10 4.53e-01 -1.37e-01 6.03e-01
Asparagine N-linked glycosylation 278 8.25e-05 -1.37e-01 5.04e-04
CDC6 association with the ORC:origin complex 11 4.32e-01 1.37e-01 5.85e-01
FGFR2 mutant receptor activation 29 2.02e-01 -1.37e-01 3.41e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 21 2.79e-01 -1.37e-01 4.33e-01
RUNX3 regulates NOTCH signaling 14 3.76e-01 -1.37e-01 5.31e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 1.05e-01 -1.37e-01 2.14e-01
HS-GAG biosynthesis 27 2.21e-01 1.36e-01 3.64e-01
SHC-mediated cascade:FGFR2 19 3.04e-01 1.36e-01 4.66e-01
Prolactin receptor signaling 11 4.35e-01 -1.36e-01 5.86e-01
Aspartate and asparagine metabolism 10 4.58e-01 1.35e-01 6.07e-01
Prostacyclin signalling through prostacyclin receptor 15 3.64e-01 -1.35e-01 5.19e-01
Formation of tubulin folding intermediates by CCT/TriC 23 2.64e-01 -1.35e-01 4.18e-01
Vesicle-mediated transport 609 1.83e-08 -1.33e-01 3.85e-07
Glycerophospholipid biosynthesis 110 1.58e-02 -1.33e-01 4.62e-02
HSF1-dependent transactivation 32 1.95e-01 -1.32e-01 3.33e-01
RND3 GTPase cycle 41 1.42e-01 1.32e-01 2.67e-01
Cargo recognition for clathrin-mediated endocytosis 97 2.47e-02 -1.32e-01 6.78e-02
TP53 Regulates Metabolic Genes 85 3.70e-02 -1.31e-01 9.40e-02
RHOV GTPase cycle 37 1.69e-01 -1.31e-01 3.03e-01
PPARA activates gene expression 109 1.86e-02 -1.30e-01 5.34e-02
Extension of Telomeres 51 1.08e-01 1.30e-01 2.18e-01
Retinoid metabolism and transport 32 2.03e-01 1.30e-01 3.42e-01
Activated NTRK2 signals through FRS2 and FRS3 11 4.58e-01 -1.29e-01 6.07e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 3.30e-01 1.29e-01 4.86e-01
Listeria monocytogenes entry into host cells 20 3.18e-01 -1.29e-01 4.78e-01
Antimicrobial peptides 25 2.64e-01 1.29e-01 4.18e-01
Protein localization 159 5.00e-03 -1.29e-01 1.74e-02
Biosynthesis of DHA-derived SPMs 13 4.21e-01 -1.29e-01 5.76e-01
Killing mechanisms 11 4.60e-01 1.29e-01 6.08e-01
WNT5:FZD7-mediated leishmania damping 11 4.60e-01 1.29e-01 6.08e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 1.77e-01 -1.28e-01 3.14e-01
Signaling by EGFR 48 1.25e-01 -1.28e-01 2.42e-01
Regulation of lipid metabolism by PPARalpha 111 2.00e-02 -1.28e-01 5.73e-02
Diseases of programmed cell death 61 8.45e-02 -1.28e-01 1.84e-01
Unblocking of NMDA receptors, glutamate binding and activation 19 3.35e-01 -1.28e-01 4.93e-01
Gap junction trafficking 19 3.37e-01 1.27e-01 4.93e-01
MTOR signalling 40 1.64e-01 -1.27e-01 2.99e-01
RET signaling 37 1.81e-01 -1.27e-01 3.17e-01
Digestion and absorption 10 4.87e-01 -1.27e-01 6.33e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 3.28e-01 -1.26e-01 4.85e-01
Neurodegenerative Diseases 20 3.28e-01 -1.26e-01 4.85e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 2.47e-01 -1.26e-01 4.00e-01
Activation of SMO 18 3.54e-01 -1.26e-01 5.09e-01
RND1 GTPase cycle 42 1.58e-01 1.26e-01 2.92e-01
Mitotic Spindle Checkpoint 109 2.34e-02 -1.26e-01 6.52e-02
G-protein beta:gamma signalling 28 2.50e-01 -1.26e-01 4.03e-01
Role of phospholipids in phagocytosis 22 3.08e-01 -1.26e-01 4.69e-01
PI-3K cascade:FGFR1 18 3.57e-01 -1.25e-01 5.11e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 92 3.90e-02 -1.25e-01 9.74e-02
Amplification of signal from the kinetochores 92 3.90e-02 -1.25e-01 9.74e-02
Defective GALNT3 causes HFTC 10 4.96e-01 1.24e-01 6.41e-01
SHC-mediated cascade:FGFR4 16 3.89e-01 1.24e-01 5.44e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 35 2.05e-01 -1.24e-01 3.43e-01
Metabolic disorders of biological oxidation enzymes 28 2.57e-01 1.24e-01 4.10e-01
HDR through Single Strand Annealing (SSA) 37 1.93e-01 1.24e-01 3.32e-01
Triglyceride catabolism 17 3.78e-01 1.23e-01 5.33e-01
Phospholipase C-mediated cascade; FGFR3 11 4.79e-01 1.23e-01 6.25e-01
RAS processing 19 3.53e-01 -1.23e-01 5.07e-01
Transcriptional regulation of white adipocyte differentiation 81 5.59e-02 -1.23e-01 1.30e-01
tRNA modification in the nucleus and cytosol 43 1.64e-01 -1.23e-01 2.99e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 28 2.63e-01 1.22e-01 4.17e-01
Trafficking of AMPA receptors 28 2.63e-01 1.22e-01 4.17e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.67e-01 -1.22e-01 3.01e-01
Recycling of bile acids and salts 14 4.30e-01 1.22e-01 5.85e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 97 3.87e-02 1.21e-01 9.71e-02
Signaling by Non-Receptor Tyrosine Kinases 53 1.26e-01 -1.21e-01 2.43e-01
Signaling by PTK6 53 1.26e-01 -1.21e-01 2.43e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.94e-01 1.21e-01 4.55e-01
Cell recruitment (pro-inflammatory response) 23 3.15e-01 -1.21e-01 4.77e-01
Purinergic signaling in leishmaniasis infection 23 3.15e-01 -1.21e-01 4.77e-01
Nicotinamide salvaging 18 3.76e-01 1.21e-01 5.31e-01
Resolution of Sister Chromatid Cohesion 105 3.35e-02 -1.20e-01 8.65e-02
Amino acids regulate mTORC1 51 1.38e-01 -1.20e-01 2.61e-01
Eicosanoid ligand-binding receptors 13 4.54e-01 -1.20e-01 6.03e-01
Cytosolic iron-sulfur cluster assembly 13 4.54e-01 1.20e-01 6.03e-01
Adaptive Immune System 648 1.91e-07 -1.20e-01 2.73e-06
Signaling by BRAF and RAF1 fusions 60 1.09e-01 -1.20e-01 2.20e-01
tRNA processing 124 2.17e-02 -1.19e-01 6.13e-02
Netrin-1 signaling 45 1.67e-01 -1.19e-01 3.01e-01
Nervous system development 526 2.94e-06 -1.19e-01 2.62e-05
Telomere Extension By Telomerase 23 3.25e-01 -1.19e-01 4.83e-01
Regulation of TP53 Activity through Phosphorylation 91 5.07e-02 -1.18e-01 1.21e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 4.96e-01 1.18e-01 6.41e-01
Glucagon signaling in metabolic regulation 27 2.88e-01 -1.18e-01 4.47e-01
G0 and Early G1 27 2.89e-01 1.18e-01 4.48e-01
Complex I biogenesis 57 1.25e-01 -1.17e-01 2.42e-01
STAT3 nuclear events downstream of ALK signaling 10 5.21e-01 1.17e-01 6.66e-01
cGMP effects 14 4.49e-01 1.17e-01 6.00e-01
EML4 and NUDC in mitotic spindle formation 96 4.87e-02 -1.16e-01 1.17e-01
Signalling to RAS 20 3.68e-01 -1.16e-01 5.22e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.52e-01 1.16e-01 6.03e-01
Xenobiotics 14 4.53e-01 1.16e-01 6.03e-01
Glutamate Neurotransmitter Release Cycle 23 3.36e-01 -1.16e-01 4.93e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 125 2.55e-02 -1.16e-01 6.94e-02
Post-translational protein modification 1268 3.98e-12 -1.15e-01 1.54e-10
NOD1/2 Signaling Pathway 32 2.59e-01 -1.15e-01 4.12e-01
Negative regulation of MET activity 21 3.63e-01 -1.15e-01 5.18e-01
FGFR3 ligand binding and activation 11 5.11e-01 1.15e-01 6.57e-01
FGFR3c ligand binding and activation 11 5.11e-01 1.15e-01 6.57e-01
Dissolution of Fibrin Clot 12 4.94e-01 1.14e-01 6.39e-01
Sensory processing of sound by outer hair cells of the cochlea 45 1.86e-01 1.14e-01 3.23e-01
SHC-mediated cascade:FGFR3 16 4.31e-01 1.14e-01 5.85e-01
RAF/MAP kinase cascade 250 1.95e-03 -1.14e-01 7.68e-03
ERBB2 Regulates Cell Motility 14 4.62e-01 -1.14e-01 6.10e-01
SUMOylation of intracellular receptors 27 3.09e-01 1.13e-01 4.69e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.81e-01 -1.13e-01 5.35e-01
Axon guidance 504 1.34e-05 -1.13e-01 1.02e-04
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 4.65e-01 1.13e-01 6.10e-01
Formation of the beta-catenin:TCF transactivating complex 52 1.59e-01 -1.13e-01 2.94e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 5.38e-01 1.12e-01 6.78e-01
FCERI mediated Ca+2 mobilization 28 3.03e-01 -1.12e-01 4.66e-01
Inositol phosphate metabolism 46 1.88e-01 -1.12e-01 3.26e-01
MAPK1/MAPK3 signaling 256 2.06e-03 -1.12e-01 8.06e-03
CD28 dependent PI3K/Akt signaling 18 4.12e-01 -1.12e-01 5.66e-01
Gap junction trafficking and regulation 21 3.76e-01 1.12e-01 5.31e-01
CDC42 GTPase cycle 153 1.72e-02 1.12e-01 4.99e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.88e-01 -1.11e-01 6.35e-01
Synthesis of PIPs at the plasma membrane 50 1.77e-01 -1.10e-01 3.14e-01
Signaling by ERBB2 49 1.83e-01 -1.10e-01 3.20e-01
Apoptotic execution phase 48 1.88e-01 1.10e-01 3.26e-01
Extracellular matrix organization 259 2.46e-03 1.09e-01 9.37e-03
MAPK family signaling cascades 295 1.29e-03 -1.09e-01 5.37e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 5.15e-01 -1.09e-01 6.61e-01
Smooth Muscle Contraction 32 2.88e-01 1.09e-01 4.47e-01
IRAK1 recruits IKK complex 10 5.54e-01 -1.08e-01 6.93e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 5.54e-01 -1.08e-01 6.93e-01
Innate Immune System 848 9.23e-08 -1.08e-01 1.56e-06
Cargo trafficking to the periciliary membrane 47 2.01e-01 -1.08e-01 3.40e-01
VxPx cargo-targeting to cilium 19 4.22e-01 -1.06e-01 5.77e-01
Signaling by NOTCH2 32 3.03e-01 1.05e-01 4.66e-01
PD-1 signaling 17 4.55e-01 1.05e-01 6.04e-01
PI3K/AKT Signaling in Cancer 90 8.66e-02 -1.04e-01 1.87e-01
RHOB GTPase cycle 69 1.33e-01 1.04e-01 2.55e-01
Transcription of E2F targets under negative control by DREAM complex 19 4.34e-01 1.04e-01 5.86e-01
RHOJ GTPase cycle 54 1.90e-01 1.03e-01 3.28e-01
Interleukin-7 signaling 23 3.93e-01 1.03e-01 5.46e-01
Immune System 1635 3.24e-12 -1.03e-01 1.29e-10
Muscle contraction 160 2.50e-02 1.03e-01 6.82e-02
Metal ion SLC transporters 23 3.95e-01 -1.02e-01 5.48e-01
Role of LAT2/NTAL/LAB on calcium mobilization 13 5.24e-01 -1.02e-01 6.69e-01
RHO GTPase Effectors 254 5.07e-03 -1.02e-01 1.76e-02
MET activates RAS signaling 11 5.61e-01 -1.01e-01 7.00e-01
FGFR1c ligand binding and activation 10 5.80e-01 -1.01e-01 7.16e-01
Transferrin endocytosis and recycling 30 3.39e-01 1.01e-01 4.95e-01
FGFR1 mutant receptor activation 29 3.48e-01 -1.01e-01 5.02e-01
Initial triggering of complement 13 5.30e-01 -1.01e-01 6.74e-01
Recognition of DNA damage by PCNA-containing replication complex 30 3.44e-01 -9.99e-02 4.99e-01
Costimulation by the CD28 family 58 1.89e-01 -9.97e-02 3.27e-01
Processing of DNA double-strand break ends 72 1.44e-01 -9.95e-02 2.71e-01
Death Receptor Signalling 137 4.45e-02 -9.94e-02 1.09e-01
Protein-protein interactions at synapses 80 1.25e-01 -9.92e-02 2.42e-01
Plasma lipoprotein assembly, remodeling, and clearance 57 1.96e-01 9.90e-02 3.34e-01
The role of Nef in HIV-1 replication and disease pathogenesis 23 4.11e-01 -9.90e-02 5.65e-01
Regulation of PLK1 Activity at G2/M Transition 87 1.14e-01 -9.81e-02 2.27e-01
Degradation of cysteine and homocysteine 11 5.74e-01 9.79e-02 7.12e-01
IRAK4 deficiency (TLR2/4) 15 5.12e-01 9.77e-02 6.59e-01
Transcriptional regulation of testis differentiation 11 5.76e-01 9.75e-02 7.13e-01
RUNX2 regulates osteoblast differentiation 22 4.30e-01 -9.73e-02 5.85e-01
WNT5A-dependent internalization of FZD4 15 5.15e-01 9.71e-02 6.61e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 38 3.01e-01 -9.70e-02 4.63e-01
Cardiac conduction 108 8.16e-02 9.70e-02 1.79e-01
Apoptosis 170 2.97e-02 -9.66e-02 7.81e-02
G2/M DNA damage checkpoint 69 1.67e-01 -9.63e-02 3.01e-01
eNOS activation 11 5.81e-01 9.61e-02 7.16e-01
Chaperone Mediated Autophagy 17 4.93e-01 -9.60e-02 6.39e-01
RHO GTPases Activate Formins 118 7.22e-02 -9.58e-02 1.61e-01
Defective pyroptosis 34 3.37e-01 -9.52e-02 4.93e-01
Peroxisomal lipid metabolism 27 3.93e-01 9.49e-02 5.46e-01
Acyl chain remodelling of PG 11 5.86e-01 -9.49e-02 7.20e-01
FLT3 signaling in disease 28 3.86e-01 -9.45e-02 5.40e-01
Activation of G protein gated Potassium channels 23 4.33e-01 -9.45e-02 5.85e-01
G protein gated Potassium channels 23 4.33e-01 -9.45e-02 5.85e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 23 4.33e-01 -9.45e-02 5.85e-01
Elastic fibre formation 36 3.27e-01 9.45e-02 4.85e-01
G alpha (q) signalling events 156 4.30e-02 -9.38e-02 1.06e-01
Dermatan sulfate biosynthesis 11 5.91e-01 9.35e-02 7.26e-01
Caspase activation via Death Receptors in the presence of ligand 15 5.31e-01 9.34e-02 6.74e-01
ERBB2 Activates PTK6 Signaling 12 5.76e-01 -9.33e-02 7.13e-01
Complement cascade 31 3.71e-01 -9.29e-02 5.26e-01
RND2 GTPase cycle 41 3.04e-01 9.28e-02 4.66e-01
Formation of Fibrin Clot (Clotting Cascade) 24 4.33e-01 -9.24e-02 5.86e-01
PKA activation in glucagon signalling 15 5.37e-01 9.20e-02 6.78e-01
Disease 1445 4.45e-09 -9.17e-02 1.13e-07
Defects in vitamin and cofactor metabolism 21 4.67e-01 9.16e-02 6.12e-01
Nucleotide catabolism 31 3.78e-01 9.14e-02 5.33e-01
Sensory processing of sound 64 2.07e-01 9.11e-02 3.45e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 2.65e-01 -9.11e-02 4.18e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.01e-01 9.11e-02 7.34e-01
Activation of GABAB receptors 35 3.52e-01 -9.10e-02 5.05e-01
GABA B receptor activation 35 3.52e-01 -9.10e-02 5.05e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 5.29e-01 -9.09e-02 6.74e-01
SARS-CoV-2 Infection 70 1.88e-01 -9.09e-02 3.26e-01
SUMOylation of DNA methylation proteins 16 5.29e-01 -9.08e-02 6.74e-01
Nuclear signaling by ERBB4 28 4.07e-01 9.05e-02 5.60e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 5.31e-01 9.04e-02 6.74e-01
GPVI-mediated activation cascade 29 4.00e-01 -9.02e-02 5.53e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 3.24e-01 -9.01e-02 4.82e-01
Signaling by RAS mutants 40 3.24e-01 -9.01e-02 4.82e-01
Signaling by moderate kinase activity BRAF mutants 40 3.24e-01 -9.01e-02 4.82e-01
Signaling downstream of RAS mutants 40 3.24e-01 -9.01e-02 4.82e-01
Pre-NOTCH Expression and Processing 70 1.92e-01 -9.01e-02 3.31e-01
Developmental Biology 857 7.72e-06 -8.97e-02 6.21e-05
COPII-mediated vesicle transport 66 2.08e-01 -8.96e-02 3.46e-01
Sphingolipid metabolism 85 1.55e-01 8.91e-02 2.89e-01
Sensory processing of sound by inner hair cells of the cochlea 59 2.37e-01 8.90e-02 3.86e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 5.80e-01 8.87e-02 7.16e-01
Deposition of new CENPA-containing nucleosomes at the centromere 44 3.09e-01 -8.87e-02 4.69e-01
Nucleosome assembly 44 3.09e-01 -8.87e-02 4.69e-01
RHOF GTPase cycle 41 3.30e-01 8.80e-02 4.86e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 76 1.85e-01 -8.79e-02 3.23e-01
Mitotic G1 phase and G1/S transition 147 6.61e-02 -8.78e-02 1.51e-01
Molecules associated with elastic fibres 26 4.40e-01 8.76e-02 5.92e-01
Endogenous sterols 22 4.77e-01 -8.75e-02 6.24e-01
Telomere C-strand synthesis initiation 13 5.87e-01 8.71e-02 7.21e-01
RHOA GTPase cycle 146 7.14e-02 8.64e-02 1.60e-01
Cell Cycle, Mitotic 512 9.00e-04 -8.56e-02 3.87e-03
Pregnenolone biosynthesis 10 6.39e-01 8.55e-02 7.63e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 5.80e-01 -8.54e-02 7.16e-01
TRAF6 mediated NF-kB activation 23 4.79e-01 -8.53e-02 6.25e-01
Diseases associated with the TLR signaling cascade 27 4.46e-01 -8.48e-02 5.96e-01
Diseases of Immune System 27 4.46e-01 -8.48e-02 5.96e-01
RAC3 GTPase cycle 89 1.69e-01 -8.42e-02 3.03e-01
Adenylate cyclase inhibitory pathway 12 6.14e-01 -8.40e-02 7.44e-01
Opioid Signalling 80 1.94e-01 -8.39e-02 3.33e-01
Downstream signaling of activated FGFR1 28 4.42e-01 -8.39e-02 5.94e-01
G beta:gamma signalling through PI3Kgamma 21 5.07e-01 -8.36e-02 6.54e-01
Glycogen metabolism 26 4.64e-01 8.29e-02 6.10e-01
Ion channel transport 153 7.69e-02 8.28e-02 1.71e-01
G alpha (12/13) signalling events 75 2.15e-01 8.27e-02 3.57e-01
Glutathione conjugation 30 4.35e-01 8.24e-02 5.86e-01
Apoptotic factor-mediated response 19 5.36e-01 -8.21e-02 6.77e-01
Signaling by VEGF 99 1.59e-01 -8.19e-02 2.94e-01
Signaling by RAF1 mutants 36 3.96e-01 -8.17e-02 5.49e-01
Intrinsic Pathway of Fibrin Clot Formation 14 5.98e-01 8.14e-02 7.31e-01
Cytochrome P450 - arranged by substrate type 42 3.63e-01 8.11e-02 5.18e-01
Signaling by ERBB2 in Cancer 25 4.83e-01 -8.11e-02 6.29e-01
LGI-ADAM interactions 11 6.43e-01 8.08e-02 7.65e-01
Programmed Cell Death 196 5.23e-02 -8.04e-02 1.24e-01
Neurotransmitter release cycle 47 3.41e-01 -8.03e-02 4.96e-01
DNA Damage Bypass 47 3.44e-01 -7.98e-02 5.00e-01
Signaling by Leptin 10 6.63e-01 -7.96e-02 7.77e-01
ECM proteoglycans 45 3.56e-01 7.95e-02 5.10e-01
Sema3A PAK dependent Axon repulsion 16 5.85e-01 -7.88e-02 7.20e-01
S Phase 160 8.73e-02 -7.83e-02 1.88e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 6.12e-01 -7.82e-02 7.43e-01
Collagen chain trimerization 40 3.92e-01 7.81e-02 5.46e-01
AURKA Activation by TPX2 72 2.53e-01 -7.79e-02 4.06e-01
Metabolism of vitamins and cofactors 172 7.81e-02 7.78e-02 1.73e-01
Mitochondrial tRNA aminoacylation 21 5.37e-01 -7.77e-02 6.78e-01
G1/S Transition 131 1.28e-01 -7.70e-02 2.46e-01
FGFR1 ligand binding and activation 13 6.32e-01 -7.66e-02 7.58e-01
Arachidonic acid metabolism 38 4.18e-01 -7.60e-02 5.72e-01
FOXO-mediated transcription 58 3.20e-01 -7.55e-02 4.80e-01
Termination of translesion DNA synthesis 32 4.60e-01 7.55e-02 6.08e-01
Integration of energy metabolism 95 2.04e-01 -7.54e-02 3.42e-01
Intra-Golgi traffic 43 3.93e-01 -7.52e-02 5.46e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 4.92e-01 7.51e-02 6.38e-01
Cell Cycle 636 1.22e-03 -7.50e-02 5.14e-03
Oncogenic MAPK signaling 77 2.56e-01 -7.48e-02 4.09e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.68e-01 -7.48e-02 7.79e-01
Constitutive Signaling by EGFRvIII 15 6.18e-01 -7.45e-02 7.45e-01
Signaling by EGFRvIII in Cancer 15 6.18e-01 -7.45e-02 7.45e-01
Regulation of MECP2 expression and activity 30 4.80e-01 -7.44e-02 6.26e-01
Purine salvage 12 6.56e-01 7.43e-02 7.74e-01
Vitamin D (calciferol) metabolism 10 6.84e-01 7.42e-02 7.91e-01
Nucleotide-like (purinergic) receptors 12 6.57e-01 7.41e-02 7.74e-01
Na+/Cl- dependent neurotransmitter transporters 11 6.72e-01 7.37e-02 7.82e-01
DARPP-32 events 23 5.42e-01 7.34e-02 6.82e-01
Cell junction organization 76 2.69e-01 7.33e-02 4.22e-01
BBSome-mediated cargo-targeting to cilium 21 5.61e-01 -7.32e-02 7.00e-01
Peptide hormone metabolism 66 3.04e-01 7.32e-02 4.66e-01
DCC mediated attractive signaling 14 6.36e-01 -7.31e-02 7.60e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 16 6.13e-01 -7.31e-02 7.43e-01
Metabolism of fat-soluble vitamins 36 4.52e-01 7.24e-02 6.03e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 90 2.35e-01 -7.24e-02 3.85e-01
PKA-mediated phosphorylation of CREB 18 5.96e-01 7.22e-02 7.30e-01
AKT phosphorylates targets in the cytosol 14 6.41e-01 -7.19e-02 7.64e-01
Phase 4 - resting membrane potential 16 6.20e-01 -7.17e-02 7.46e-01
Tryptophan catabolism 12 6.69e-01 7.13e-02 7.80e-01
Negative regulation of the PI3K/AKT network 97 2.26e-01 -7.11e-02 3.73e-01
Phospholipase C-mediated cascade: FGFR1 13 6.57e-01 -7.10e-02 7.74e-01
Synthesis of bile acids and bile salts 31 4.95e-01 -7.09e-02 6.40e-01
Activation of NMDA receptors and postsynaptic events 70 3.07e-01 -7.06e-02 4.69e-01
Keratan sulfate biosynthesis 24 5.50e-01 -7.05e-02 6.90e-01
FCGR3A-mediated IL10 synthesis 32 4.91e-01 -7.04e-02 6.37e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 6.61e-01 7.04e-02 7.77e-01
ROS and RNS production in phagocytes 31 4.98e-01 7.03e-02 6.42e-01
Interleukin-15 signaling 14 6.50e-01 7.00e-02 7.70e-01
G-protein mediated events 50 3.92e-01 -7.00e-02 5.46e-01
EPH-Ephrin signaling 91 2.50e-01 -6.97e-02 4.03e-01
Striated Muscle Contraction 26 5.39e-01 6.97e-02 6.78e-01
Aggrephagy 21 5.81e-01 -6.95e-02 7.16e-01
Homology Directed Repair 111 2.07e-01 6.93e-02 3.45e-01
Loss of Nlp from mitotic centrosomes 69 3.20e-01 -6.92e-02 4.80e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 3.20e-01 -6.92e-02 4.80e-01
VEGFA-VEGFR2 Pathway 91 2.54e-01 -6.91e-02 4.07e-01
Diseases associated with glycosylation precursor biosynthesis 18 6.13e-01 -6.89e-02 7.43e-01
Transport of vitamins, nucleosides, and related molecules 36 4.75e-01 6.87e-02 6.22e-01
Other interleukin signaling 22 5.78e-01 -6.86e-02 7.15e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 20 5.97e-01 -6.83e-02 7.30e-01
Detoxification of Reactive Oxygen Species 30 5.18e-01 -6.82e-02 6.64e-01
Metabolism of steroid hormones 28 5.33e-01 6.81e-02 6.75e-01
Insulin receptor recycling 24 5.65e-01 6.79e-02 7.03e-01
Gap junction degradation 10 7.11e-01 -6.78e-02 8.09e-01
Downregulation of ERBB2 signaling 28 5.35e-01 -6.76e-02 6.77e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 3.82e-01 -6.69e-02 5.35e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 3.82e-01 -6.69e-02 5.35e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 3.82e-01 -6.69e-02 5.35e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 3.82e-01 -6.69e-02 5.35e-01
Signaling by NOTCH1 in Cancer 57 3.82e-01 -6.69e-02 5.35e-01
Metabolism of steroids 138 1.75e-01 -6.68e-02 3.12e-01
Metabolism of water-soluble vitamins and cofactors 118 2.11e-01 6.67e-02 3.50e-01
PLC beta mediated events 46 4.37e-01 -6.62e-02 5.89e-01
Metabolism of carbohydrates 264 6.44e-02 6.61e-02 1.48e-01
Glycogen synthesis 15 6.64e-01 6.47e-02 7.78e-01
Sema4D induced cell migration and growth-cone collapse 20 6.17e-01 -6.46e-02 7.45e-01
Termination of O-glycan biosynthesis 17 6.45e-01 6.45e-02 7.67e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 6.56e-01 -6.43e-02 7.74e-01
E2F mediated regulation of DNA replication 22 6.02e-01 6.43e-02 7.34e-01
Organelle biogenesis and maintenance 272 6.83e-02 -6.42e-02 1.55e-01
Metabolism of folate and pterines 16 6.57e-01 6.41e-02 7.74e-01
Keratan sulfate/keratin metabolism 29 5.51e-01 6.40e-02 6.90e-01
Signaling by PDGF 52 4.28e-01 -6.35e-02 5.83e-01
Golgi Associated Vesicle Biogenesis 55 4.16e-01 -6.34e-02 5.71e-01
Cyclin D associated events in G1 45 4.63e-01 -6.33e-02 6.10e-01
G1 Phase 45 4.63e-01 -6.33e-02 6.10e-01
Constitutive Signaling by Overexpressed ERBB2 11 7.20e-01 6.24e-02 8.15e-01
Stimuli-sensing channels 84 3.23e-01 6.24e-02 4.82e-01
Leishmania infection 188 1.40e-01 -6.24e-02 2.64e-01
Metabolism of porphyrins 22 6.14e-01 6.22e-02 7.44e-01
Post NMDA receptor activation events 57 4.17e-01 -6.21e-02 5.72e-01
Glucose metabolism 84 3.26e-01 -6.20e-02 4.84e-01
Polo-like kinase mediated events 16 6.68e-01 -6.20e-02 7.79e-01
Regulation of TP53 Activity through Association with Co-factors 12 7.10e-01 6.20e-02 8.09e-01
Common Pathway of Fibrin Clot Formation 14 6.91e-01 6.14e-02 7.95e-01
Olfactory Signaling Pathway 21 6.27e-01 6.13e-02 7.54e-01
MECP2 regulates neuronal receptors and channels 17 6.63e-01 -6.11e-02 7.77e-01
Pyroptosis 24 6.06e-01 6.09e-02 7.38e-01
Fatty acid metabolism 148 2.02e-01 6.07e-02 3.41e-01
Signal Transduction 2177 2.73e-06 -6.07e-02 2.48e-05
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 6.66e-01 -6.04e-02 7.79e-01
RAC2 GTPase cycle 85 3.37e-01 -6.02e-02 4.93e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 6.41e-01 -6.02e-02 7.64e-01
Acetylcholine Neurotransmitter Release Cycle 15 6.90e-01 -5.95e-02 7.95e-01
Synthesis of DNA 118 2.68e-01 -5.90e-02 4.21e-01
Sensory Perception 178 1.74e-01 5.90e-02 3.10e-01
Myogenesis 25 6.10e-01 5.89e-02 7.42e-01
VEGFR2 mediated vascular permeability 27 5.97e-01 5.88e-02 7.30e-01
RHOD GTPase cycle 52 4.65e-01 5.86e-02 6.10e-01
Generation of second messenger molecules 28 5.93e-01 5.84e-02 7.27e-01
Voltage gated Potassium channels 33 5.67e-01 5.76e-02 7.04e-01
Transcriptional regulation of granulopoiesis 50 4.84e-01 -5.73e-02 6.29e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 83 3.69e-01 5.70e-02 5.24e-01
DNA Repair 297 9.27e-02 -5.67e-02 1.96e-01
AKT phosphorylates targets in the nucleus 10 7.57e-01 5.66e-02 8.40e-01
Response of Mtb to phagocytosis 22 6.47e-01 -5.64e-02 7.68e-01
Fanconi Anemia Pathway 36 5.59e-01 5.63e-02 6.98e-01
MyD88 deficiency (TLR2/4) 14 7.16e-01 5.62e-02 8.11e-01
Peptide ligand-binding receptors 106 3.18e-01 5.61e-02 4.78e-01
Transport of bile salts and organic acids, metal ions and amine compounds 60 4.55e-01 5.57e-02 6.04e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 6.30e-01 -5.57e-02 7.57e-01
Ca2+ pathway 58 4.63e-01 -5.56e-02 6.10e-01
Mitotic Prometaphase 186 1.91e-01 -5.56e-02 3.29e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 29 6.05e-01 5.55e-02 7.38e-01
Keratinization 56 4.73e-01 -5.55e-02 6.19e-01
RUNX2 regulates bone development 29 6.05e-01 -5.54e-02 7.38e-01
Signaling by cytosolic FGFR1 fusion mutants 18 6.85e-01 -5.53e-02 7.91e-01
Signaling by NOTCH1 72 4.18e-01 -5.52e-02 5.72e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 7.13e-01 -5.49e-02 8.11e-01
Inwardly rectifying K+ channels 28 6.15e-01 -5.48e-02 7.44e-01
Glycogen breakdown (glycogenolysis) 15 7.13e-01 5.48e-02 8.11e-01
Depolymerisation of the Nuclear Lamina 15 7.15e-01 -5.44e-02 8.11e-01
Long-term potentiation 21 6.69e-01 -5.39e-02 7.80e-01
RHO GTPases activate IQGAPs 11 7.57e-01 -5.38e-02 8.40e-01
SUMOylation of transcription factors 19 6.85e-01 -5.38e-02 7.91e-01
Cytosolic sulfonation of small molecules 22 6.63e-01 5.37e-02 7.77e-01
Signaling by ALK 26 6.37e-01 -5.34e-02 7.61e-01
DNA Replication 150 2.63e-01 -5.29e-02 4.17e-01
rRNA processing in the mitochondrion 24 6.55e-01 5.27e-02 7.74e-01
SHC1 events in ERBB2 signaling 21 6.80e-01 -5.19e-02 7.89e-01
Signaling by FLT3 fusion proteins 19 6.96e-01 -5.18e-02 7.98e-01
Sensory perception of taste 25 6.55e-01 -5.17e-02 7.74e-01
Sema4D in semaphorin signaling 24 6.62e-01 -5.15e-02 7.77e-01
Biosynthesis of specialized proresolving mediators (SPMs) 14 7.39e-01 -5.14e-02 8.32e-01
EPH-ephrin mediated repulsion of cells 48 5.38e-01 5.14e-02 6.78e-01
mTORC1-mediated signalling 24 6.66e-01 -5.08e-02 7.79e-01
TRP channels 18 7.09e-01 5.08e-02 8.08e-01
Nitric oxide stimulates guanylate cyclase 18 7.15e-01 4.96e-02 8.11e-01
Miscellaneous transport and binding events 23 6.81e-01 -4.96e-02 7.89e-01
Meiotic synapsis 49 5.51e-01 -4.93e-02 6.90e-01
Regulated proteolysis of p75NTR 11 7.79e-01 4.90e-02 8.60e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 6.73e-01 4.88e-02 7.83e-01
RAC1 GTPase cycle 176 2.64e-01 4.88e-02 4.18e-01
NRAGE signals death through JNK 59 5.19e-01 4.86e-02 6.64e-01
Transcriptional Regulation by MECP2 56 5.34e-01 4.81e-02 6.76e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 6.78e-01 4.79e-02 7.88e-01
Interleukin-37 signaling 21 7.05e-01 4.78e-02 8.05e-01
Metabolism 1871 5.95e-04 -4.76e-02 2.72e-03
Regulated Necrosis 51 5.56e-01 -4.76e-02 6.95e-01
RHO GTPases activate PAKs 21 7.08e-01 -4.73e-02 8.07e-01
Acyl chain remodelling of PC 19 7.22e-01 -4.72e-02 8.16e-01
Cargo concentration in the ER 31 6.49e-01 -4.72e-02 7.70e-01
Signaling by ERBB2 KD Mutants 24 6.94e-01 -4.64e-02 7.96e-01
Platelet activation, signaling and aggregation 224 2.36e-01 -4.59e-02 3.85e-01
WNT ligand biogenesis and trafficking 25 6.93e-01 -4.57e-02 7.95e-01
Constitutive Signaling by Aberrant PI3K in Cancer 63 5.32e-01 -4.55e-02 6.74e-01
Response to elevated platelet cytosolic Ca2+ 114 4.02e-01 4.55e-02 5.53e-01
RHOQ GTPase cycle 58 5.50e-01 4.53e-02 6.90e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 6.90e-01 -4.52e-02 7.95e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 8.07e-01 -4.45e-02 8.79e-01
Elevation of cytosolic Ca2+ levels 12 7.91e-01 4.42e-02 8.71e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 17 7.53e-01 -4.41e-02 8.39e-01
CASP8 activity is inhibited 10 8.10e-01 4.40e-02 8.79e-01
Dimerization of procaspase-8 10 8.10e-01 4.40e-02 8.79e-01
Regulation by c-FLIP 10 8.10e-01 4.40e-02 8.79e-01
G alpha (s) signalling events 93 4.66e-01 4.38e-02 6.11e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 8.11e-01 -4.36e-02 8.79e-01
Transcriptional regulation of pluripotent stem cells 30 6.81e-01 4.34e-02 7.89e-01
Recycling pathway of L1 27 6.96e-01 -4.34e-02 7.98e-01
Class B/2 (Secretin family receptors) 72 5.25e-01 4.33e-02 6.70e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 641 6.11e-02 -4.33e-02 1.41e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 105 4.44e-01 4.32e-02 5.96e-01
Growth hormone receptor signaling 20 7.41e-01 -4.27e-02 8.33e-01
Cristae formation 31 6.81e-01 -4.26e-02 7.89e-01
Advanced glycosylation endproduct receptor signaling 11 8.09e-01 4.21e-02 8.79e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 8.18e-01 4.20e-02 8.83e-01
PI-3K cascade:FGFR2 19 7.54e-01 4.15e-02 8.40e-01
VEGFR2 mediated cell proliferation 19 7.56e-01 -4.11e-02 8.40e-01
Interleukin-6 family signaling 23 7.33e-01 4.11e-02 8.28e-01
Signaling by FGFR3 in disease 20 7.52e-01 -4.08e-02 8.39e-01
Signaling by FGFR3 point mutants in cancer 20 7.52e-01 -4.08e-02 8.39e-01
Ca-dependent events 34 6.91e-01 -3.93e-02 7.95e-01
Nuclear Receptor transcription pathway 46 6.50e-01 -3.87e-02 7.70e-01
Repression of WNT target genes 14 8.02e-01 -3.86e-02 8.76e-01
Metabolism of lipids 649 9.44e-02 -3.84e-02 1.99e-01
Condensation of Prometaphase Chromosomes 11 8.26e-01 -3.83e-02 8.87e-01
Cell death signalling via NRAGE, NRIF and NADE 76 5.68e-01 3.79e-02 7.05e-01
Formation of ATP by chemiosmotic coupling 18 7.81e-01 -3.78e-02 8.61e-01
Signaling by ERBB2 TMD/JMD mutants 21 7.64e-01 -3.78e-02 8.45e-01
Aquaporin-mediated transport 37 6.92e-01 3.77e-02 7.95e-01
Glutamate and glutamine metabolism 13 8.16e-01 3.73e-02 8.82e-01
Collagen degradation 36 6.99e-01 -3.73e-02 8.00e-01
Chemokine receptors bind chemokines 27 7.39e-01 -3.71e-02 8.32e-01
Signaling by Rho GTPases 625 1.13e-01 -3.71e-02 2.26e-01
ADORA2B mediated anti-inflammatory cytokines production 82 5.62e-01 3.70e-02 7.00e-01
Neutrophil degranulation 414 2.01e-01 -3.66e-02 3.39e-01
SLC-mediated transmembrane transport 200 3.75e-01 3.64e-02 5.30e-01
Platelet degranulation 109 5.18e-01 3.58e-02 6.64e-01
Translesion synthesis by POLK 17 8.01e-01 3.53e-02 8.75e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 36 7.19e-01 3.47e-02 8.14e-01
Interconversion of nucleotide di- and triphosphates 29 7.47e-01 -3.46e-02 8.37e-01
Processive synthesis on the C-strand of the telomere 19 7.94e-01 3.46e-02 8.72e-01
Apoptosis induced DNA fragmentation 12 8.36e-01 -3.45e-02 8.94e-01
ALK mutants bind TKIs 12 8.36e-01 -3.45e-02 8.94e-01
Visual phototransduction 72 6.16e-01 3.42e-02 7.44e-01
Phase I - Functionalization of compounds 72 6.20e-01 -3.38e-02 7.47e-01
Signaling by high-kinase activity BRAF mutants 31 7.45e-01 -3.37e-02 8.36e-01
Insulin receptor signalling cascade 48 6.89e-01 -3.33e-02 7.95e-01
RHO GTPases Activate NADPH Oxidases 20 8.00e-01 3.28e-02 8.75e-01
FRS-mediated FGFR3 signaling 18 8.10e-01 -3.28e-02 8.79e-01
Vasopressin regulates renal water homeostasis via Aquaporins 35 7.38e-01 3.27e-02 8.32e-01
NRIF signals cell death from the nucleus 16 8.22e-01 -3.25e-02 8.85e-01
Platelet homeostasis 72 6.34e-01 3.24e-02 7.59e-01
FOXO-mediated transcription of cell cycle genes 15 8.29e-01 -3.21e-02 8.89e-01
GPCR ligand binding 271 3.63e-01 3.21e-02 5.18e-01
RHOG GTPase cycle 74 6.34e-01 -3.20e-02 7.59e-01
GPCR downstream signalling 428 2.58e-01 3.18e-02 4.11e-01
Basigin interactions 23 7.92e-01 3.18e-02 8.71e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 8.00e-01 -3.12e-02 8.75e-01
L1CAM interactions 93 6.07e-01 -3.08e-02 7.39e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 7.49e-01 3.08e-02 8.38e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 7.44e-01 3.06e-02 8.35e-01
DNA Double-Strand Break Repair 140 5.32e-01 3.06e-02 6.74e-01
Transmission across Chemical Synapses 216 4.42e-01 3.03e-02 5.94e-01
Downstream signaling of activated FGFR3 23 8.02e-01 -3.02e-02 8.76e-01
RA biosynthesis pathway 18 8.26e-01 3.00e-02 8.87e-01
Pre-NOTCH Transcription and Translation 54 7.04e-01 -2.98e-02 8.05e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 8.64e-01 -2.97e-02 9.15e-01
Regulation of FZD by ubiquitination 21 8.16e-01 -2.93e-02 8.82e-01
p75 NTR receptor-mediated signalling 94 6.31e-01 -2.86e-02 7.58e-01
TNFs bind their physiological receptors 20 8.27e-01 -2.82e-02 8.88e-01
Infection with Mycobacterium tuberculosis 24 8.14e-01 -2.77e-02 8.81e-01
Sulfur amino acid metabolism 25 8.11e-01 -2.76e-02 8.79e-01
Phase II - Conjugation of compounds 77 6.76e-01 2.75e-02 7.86e-01
Anchoring of the basal body to the plasma membrane 97 6.43e-01 2.72e-02 7.65e-01
Class A/1 (Rhodopsin-like receptors) 186 5.23e-01 2.71e-02 6.68e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 34 7.88e-01 2.67e-02 8.68e-01
IGF1R signaling cascade 47 7.58e-01 2.60e-02 8.40e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 47 7.58e-01 2.60e-02 8.40e-01
PECAM1 interactions 11 8.82e-01 -2.58e-02 9.26e-01
Cell-Cell communication 106 6.47e-01 -2.57e-02 7.68e-01
Factors involved in megakaryocyte development and platelet production 116 6.32e-01 2.57e-02 7.58e-01
Intrinsic Pathway for Apoptosis 53 7.47e-01 2.56e-02 8.37e-01
SHC-mediated cascade:FGFR1 18 8.51e-01 -2.55e-02 9.04e-01
Signaling by Receptor Tyrosine Kinases 474 3.42e-01 -2.54e-02 4.98e-01
Signaling by ERBB4 52 7.51e-01 2.54e-02 8.39e-01
The canonical retinoid cycle in rods (twilight vision) 17 8.56e-01 2.54e-02 9.09e-01
Fatty acyl-CoA biosynthesis 35 7.96e-01 2.52e-02 8.73e-01
Neuronal System 333 4.31e-01 2.51e-02 5.85e-01
Signaling by GPCR 486 3.47e-01 2.49e-02 5.01e-01
Iron uptake and transport 56 7.48e-01 2.48e-02 8.37e-01
IRS-mediated signalling 43 7.79e-01 -2.47e-02 8.60e-01
Peroxisomal protein import 60 7.42e-01 2.46e-02 8.33e-01
Neurexins and neuroligins 51 7.61e-01 -2.46e-02 8.43e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 8.79e-01 2.44e-02 9.26e-01
Activation of BH3-only proteins 29 8.20e-01 2.44e-02 8.85e-01
Vitamin B5 (pantothenate) metabolism 17 8.62e-01 2.44e-02 9.14e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 8.71e-01 -2.42e-02 9.21e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 8.71e-01 -2.42e-02 9.21e-01
NOTCH2 intracellular domain regulates transcription 11 8.90e-01 -2.41e-02 9.30e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 8.95e-01 -2.41e-02 9.33e-01
Interleukin-2 family signaling 34 8.10e-01 2.38e-02 8.79e-01
FRS-mediated FGFR4 signaling 18 8.63e-01 -2.34e-02 9.15e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 91 7.05e-01 -2.30e-02 8.05e-01
Downstream signaling of activated FGFR4 23 8.49e-01 -2.29e-02 9.04e-01
Diseases of mitotic cell cycle 38 8.17e-01 2.17e-02 8.82e-01
Signaling by MET 66 7.61e-01 -2.16e-02 8.43e-01
Telomere Maintenance 84 7.32e-01 -2.16e-02 8.27e-01
MASTL Facilitates Mitotic Progression 10 9.06e-01 2.16e-02 9.41e-01
Amino acid transport across the plasma membrane 29 8.41e-01 -2.15e-02 8.98e-01
CRMPs in Sema3A signaling 16 8.82e-01 2.15e-02 9.26e-01
MHC class II antigen presentation 98 7.15e-01 2.13e-02 8.11e-01
Neurotransmitter receptors and postsynaptic signal transmission 156 6.50e-01 2.10e-02 7.70e-01
SARS-CoV-1 Infection 49 7.99e-01 2.10e-02 8.75e-01
Diseases associated with N-glycosylation of proteins 17 8.84e-01 2.05e-02 9.27e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 8.07e-01 -2.04e-02 8.79e-01
RHOH GTPase cycle 35 8.35e-01 -2.03e-02 8.94e-01
NCAM signaling for neurite out-growth 55 7.95e-01 2.02e-02 8.73e-01
Recruitment of NuMA to mitotic centrosomes 80 7.55e-01 -2.02e-02 8.40e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 8.81e-01 -1.98e-02 9.26e-01
Fertilization 16 8.92e-01 -1.97e-02 9.31e-01
Acyl chain remodelling of PE 19 8.83e-01 1.95e-02 9.26e-01
Branched-chain amino acid catabolism 21 8.79e-01 1.93e-02 9.26e-01
Trafficking and processing of endosomal TLR 11 9.12e-01 -1.92e-02 9.45e-01
Regulation of insulin secretion 66 7.91e-01 1.88e-02 8.71e-01
Interleukin-4 and Interleukin-13 signaling 96 7.52e-01 -1.86e-02 8.39e-01
Interleukin-10 signaling 34 8.51e-01 1.86e-02 9.04e-01
Retrograde transport at the Trans-Golgi-Network 49 8.25e-01 -1.83e-02 8.87e-01
Interleukin receptor SHC signaling 21 8.88e-01 1.78e-02 9.29e-01
Translesion synthesis by POLI 17 8.99e-01 -1.77e-02 9.36e-01
Downregulation of ERBB2:ERBB3 signaling 13 9.12e-01 -1.77e-02 9.45e-01
Acyl chain remodelling of PS 15 9.06e-01 1.76e-02 9.41e-01
Degradation of the extracellular matrix 94 7.68e-01 -1.76e-02 8.49e-01
Notch-HLH transcription pathway 28 8.73e-01 -1.75e-02 9.21e-01
G alpha (z) signalling events 39 8.52e-01 1.73e-02 9.04e-01
Activation of Ca-permeable Kainate Receptor 10 9.27e-01 -1.67e-02 9.52e-01
Ionotropic activity of kainate receptors 10 9.27e-01 -1.67e-02 9.52e-01
G alpha (i) signalling events 200 6.90e-01 1.64e-02 7.95e-01
Signaling by NOTCH3 46 8.48e-01 1.63e-02 9.04e-01
GABA receptor activation 45 8.51e-01 -1.62e-02 9.04e-01
Amyloid fiber formation 59 8.32e-01 1.60e-02 8.91e-01
Carnitine metabolism 11 9.28e-01 1.58e-02 9.52e-01
Plasma lipoprotein remodeling 24 8.94e-01 1.58e-02 9.32e-01
Acetylcholine regulates insulin secretion 10 9.32e-01 1.56e-02 9.54e-01
DAG and IP3 signaling 38 8.70e-01 -1.54e-02 9.20e-01
Rap1 signalling 15 9.22e-01 1.45e-02 9.51e-01
Cilium Assembly 181 7.38e-01 1.44e-02 8.32e-01
CaM pathway 32 8.89e-01 1.43e-02 9.29e-01
Calmodulin induced events 32 8.89e-01 1.43e-02 9.29e-01
Chromosome Maintenance 109 8.00e-01 -1.40e-02 8.75e-01
Kinesins 40 8.79e-01 1.39e-02 9.26e-01
Meiosis 75 8.36e-01 1.38e-02 8.94e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 13 9.32e-01 1.37e-02 9.54e-01
Transport of small molecules 605 5.66e-01 1.37e-02 7.03e-01
Signaling by ERBB2 ECD mutants 16 9.27e-01 1.33e-02 9.52e-01
Regulation of BACH1 activity 11 9.41e-01 1.28e-02 9.61e-01
Dual Incision in GG-NER 41 8.89e-01 -1.26e-02 9.29e-01
Anti-inflammatory response favouring Leishmania parasite infection 107 8.24e-01 1.24e-02 8.87e-01
Leishmania parasite growth and survival 107 8.24e-01 1.24e-02 8.87e-01
Synthesis of PC 26 9.14e-01 -1.23e-02 9.46e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 9.29e-01 1.21e-02 9.52e-01
The phototransduction cascade 27 9.14e-01 -1.20e-02 9.46e-01
PI-3K cascade:FGFR4 16 9.34e-01 1.19e-02 9.55e-01
Lysine catabolism 12 9.43e-01 1.18e-02 9.62e-01
Translation of Structural Proteins 29 9.17e-01 -1.11e-02 9.48e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 9.16e-01 1.11e-02 9.48e-01
Signaling by Insulin receptor 71 8.73e-01 -1.10e-02 9.21e-01
MET promotes cell motility 29 9.28e-01 -9.76e-03 9.52e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 9.37e-01 -9.50e-03 9.58e-01
Transcriptional Regulation by E2F6 34 9.26e-01 -9.22e-03 9.52e-01
PI3K Cascade 39 9.21e-01 -9.15e-03 9.51e-01
Maturation of nucleoprotein 11 9.61e-01 8.41e-03 9.74e-01
Meiotic recombination 45 9.23e-01 -8.38e-03 9.51e-01
FRS-mediated FGFR2 signaling 21 9.47e-01 8.37e-03 9.64e-01
Reproduction 91 8.96e-01 7.89e-03 9.34e-01
Insulin processing 25 9.47e-01 7.65e-03 9.64e-01
Effects of PIP2 hydrolysis 24 9.49e-01 -7.54e-03 9.65e-01
Centrosome maturation 81 9.07e-01 -7.52e-03 9.41e-01
Recruitment of mitotic centrosome proteins and complexes 81 9.07e-01 -7.52e-03 9.41e-01
Tight junction interactions 20 9.55e-01 7.36e-03 9.69e-01
Base Excision Repair 63 9.20e-01 -7.33e-03 9.50e-01
Assembly of active LPL and LIPC lipase complexes 13 9.66e-01 -6.79e-03 9.76e-01
RHOU GTPase cycle 40 9.42e-01 -6.69e-03 9.61e-01
GABA synthesis, release, reuptake and degradation 18 9.62e-01 6.53e-03 9.74e-01
Glucagon-type ligand receptors 23 9.57e-01 -6.43e-03 9.71e-01
Suppression of phagosomal maturation 13 9.68e-01 -6.38e-03 9.76e-01
trans-Golgi Network Vesicle Budding 71 9.28e-01 -6.19e-03 9.52e-01
Translesion synthesis by REV1 16 9.67e-01 5.96e-03 9.76e-01
Removal of the Flap Intermediate from the C-strand 17 9.68e-01 5.62e-03 9.76e-01
IRS-related events triggered by IGF1R 46 9.49e-01 5.40e-03 9.65e-01
Synthesis of IP3 and IP4 in the cytosol 25 9.64e-01 -5.23e-03 9.75e-01
Hemostasis 489 8.47e-01 5.07e-03 9.04e-01
Uptake and actions of bacterial toxins 28 9.68e-01 4.33e-03 9.76e-01
Carboxyterminal post-translational modifications of tubulin 37 9.64e-01 4.29e-03 9.75e-01
RHO GTPase cycle 433 8.80e-01 4.23e-03 9.26e-01
Cell surface interactions at the vascular wall 100 9.42e-01 4.20e-03 9.61e-01
Lysosome Vesicle Biogenesis 34 9.66e-01 4.17e-03 9.76e-01
Potassium Channels 82 9.53e-01 3.80e-03 9.68e-01
Bile acid and bile salt metabolism 39 9.76e-01 2.83e-03 9.82e-01
Downstream signaling of activated FGFR2 26 9.81e-01 2.72e-03 9.86e-01
Metabolism of nucleotides 90 9.70e-01 2.31e-03 9.76e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 14 9.89e-01 -2.06e-03 9.93e-01
Triglyceride metabolism 26 9.86e-01 -2.02e-03 9.90e-01
PI-3K cascade:FGFR3 16 9.92e-01 1.45e-03 9.93e-01
RHOC GTPase cycle 72 9.86e-01 -1.17e-03 9.90e-01
MAP2K and MAPK activation 35 9.91e-01 1.11e-03 9.93e-01
Semaphorin interactions 61 9.90e-01 9.06e-04 9.93e-01
Post-chaperonin tubulin folding pathway 20 9.95e-01 8.74e-04 9.95e-01
Biological oxidations 153 9.99e-01 7.51e-05 9.99e-01


Detailed Gene set reports



Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
1008
set Receptor Mediated Mitophagy
setSize 11
pANOVA 8.03e-06
s.dist -0.777
p.adjustANOVA 6.39e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC -12015
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
CSNK2A2 -10568
MAP1LC3B -10436
MAP1LC3A -10048
CSNK2B -9864
ATG5 -8156
ATG12 -4960
FUNDC1 -3325

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC -12015
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
CSNK2A2 -10568
MAP1LC3B -10436
MAP1LC3A -10048
CSNK2B -9864
ATG5 -8156
ATG12 -4960
FUNDC1 -3325


Mucopolysaccharidoses

Mucopolysaccharidoses
720
set Mucopolysaccharidoses
setSize 11
pANOVA 1.17e-05
s.dist 0.763
p.adjustANOVA 9.08e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NAGLU 12266
ARSB 12189
GALNS 11854
IDUA 11641
SGSH 11569
GNS 11202
GLB1 10265
GUSB 9533
IDS 8281
HGSNAT 6544
HYAL1 4893

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NAGLU 12266
ARSB 12189
GALNS 11854
IDUA 11641
SGSH 11569
GNS 11202
GLB1 10265
GUSB 9533
IDS 8281
HGSNAT 6544
HYAL1 4893


Membrane binding and targetting of GAG proteins

Membrane binding and targetting of GAG proteins
670
set Membrane binding and targetting of GAG proteins
setSize 14
pANOVA 4.02e-05
s.dist -0.634
p.adjustANOVA 0.000267



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS37D -12061
VPS37A -11954
UBAP1 -11859
UBC -11024
VPS37C -10260
TSG101 -9839
VPS28 -8884
MVB12B -8325
UBA52 -7355
UBB -6063
NMT2 -5382
VPS37B -4426
MVB12A -4012
RPS27A 5458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS37D -12061
VPS37A -11954
UBAP1 -11859
UBC -11024
VPS37C -10260
TSG101 -9839
VPS28 -8884
MVB12B -8325
UBA52 -7355
UBB -6063
NMT2 -5382
VPS37B -4426
MVB12A -4012
RPS27A 5458


Synthesis And Processing Of GAG, GAGPOL Polyproteins

Synthesis And Processing Of GAG, GAGPOL Polyproteins
1264
set Synthesis And Processing Of GAG, GAGPOL Polyproteins
setSize 14
pANOVA 4.02e-05
s.dist -0.634
p.adjustANOVA 0.000267



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS37D -12061
VPS37A -11954
UBAP1 -11859
UBC -11024
VPS37C -10260
TSG101 -9839
VPS28 -8884
MVB12B -8325
UBA52 -7355
UBB -6063
NMT2 -5382
VPS37B -4426
MVB12A -4012
RPS27A 5458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS37D -12061
VPS37A -11954
UBAP1 -11859
UBC -11024
VPS37C -10260
TSG101 -9839
VPS28 -8884
MVB12B -8325
UBA52 -7355
UBB -6063
NMT2 -5382
VPS37B -4426
MVB12A -4012
RPS27A 5458


Unwinding of DNA

Unwinding of DNA
1411
set Unwinding of DNA
setSize 12
pANOVA 0.000283
s.dist 0.605
p.adjustANOVA 0.00148



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM2 12397
MCM3 12395
MCM4 12297
MCM8 11539
GINS4 11393
MCM5 11361
GINS2 11349
GINS1 11143
CDC45 10334
GINS3 9584
MCM7 -7516
MCM6 -9875

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM2 12397
MCM3 12395
MCM4 12297
MCM8 11539
GINS4 11393
MCM5 11361
GINS2 11349
GINS1 11143
CDC45 10334
GINS3 9584
MCM7 -7516
MCM6 -9875


Assembly Of The HIV Virion

Assembly Of The HIV Virion
93
set Assembly Of The HIV Virion
setSize 16
pANOVA 3.24e-05
s.dist -0.6
p.adjustANOVA 0.000224



Top enriched genes

Top 20 genes
GeneID Gene Rank
FURIN -12177
VPS37D -12061
VPS37A -11954
UBAP1 -11859
UBC -11024
VPS37C -10260
TSG101 -9839
VPS28 -8884
MVB12B -8325
UBA52 -7355
UBB -6063
NMT2 -5382
VPS37B -4426
MVB12A -4012
PPIA 3841
RPS27A 5458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FURIN -12177
VPS37D -12061
VPS37A -11954
UBAP1 -11859
UBC -11024
VPS37C -10260
TSG101 -9839
VPS28 -8884
MVB12B -8325
UBA52 -7355
UBB -6063
NMT2 -5382
VPS37B -4426
MVB12A -4012
PPIA 3841
RPS27A 5458


Biotin transport and metabolism

Biotin transport and metabolism
121
set Biotin transport and metabolism
setSize 11
pANOVA 0.00111
s.dist 0.568
p.adjustANOVA 0.00471



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCCC1 12328
ACACA 11690
BTD 11665
PCCA 11587
ACACB 11044
PC 10745
PDZD11 10315
MCCC2 8387
PCCB 2999
HLCS 2045
SLC5A6 -9633

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCCC1 12328
ACACA 11690
BTD 11665
PCCA 11587
ACACB 11044
PC 10745
PDZD11 10315
MCCC2 8387
PCCB 2999
HLCS 2045
SLC5A6 -9633


Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Synthesis of active ubiquitin: roles of E1 and E2 enzymes
1276
set Synthesis of active ubiquitin: roles of E1 and E2 enzymes
setSize 30
pANOVA 9.32e-08
s.dist -0.563
p.adjustANOVA 1.56e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBE2R2 -11999
USP7 -11933
UBE2A -11512
UBE2L3 -11225
UBA1 -11117
UBC -11024
UBE2Q2 -10610
UBE2G1 -10537
UBE2D1 -10173
UBE2K -9910
UBE2S -9692
UBE2D2 -9286
UBE2E1 -9251
OTULIN -9052
UBE2W -9038
UBE2E3 -8906
UBA6 -8737
UBE2Z -8436
USP9X -8193
UBA52 -7355

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBE2R2 -11999
USP7 -11933
UBE2A -11512
UBE2L3 -11225
UBA1 -11117
UBC -11024
UBE2Q2 -10610
UBE2G1 -10537
UBE2D1 -10173
UBE2K -9910
UBE2S -9692
UBE2D2 -9286
UBE2E1 -9251
OTULIN -9052
UBE2W -9038
UBE2E3 -8906
UBA6 -8737
UBE2Z -8436
USP9X -8193
UBA52 -7355
CDC34 -7115
USP5 -6619
UBE2B -6195
UBB -6063
UBE2C -3443
UCHL3 1886
UBE2G2 3663
RPS27A 5458
UBE2H 7767
UBE2T 8378


SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1115
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 11
pANOVA 0.00185
s.dist -0.542
p.adjustANOVA 0.00738



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLBP -11616
ZNF473 -8727
NCBP1 -8378
NCBP2 -6900
LSM11 -6545
SNRPD3 -6094
SNRPB -5246
SNRPE -5176
SNRPF -4734
SNRPG -4164
LSM10 -3008

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLBP -11616
ZNF473 -8727
NCBP1 -8378
NCBP2 -6900
LSM11 -6545
SNRPD3 -6094
SNRPB -5246
SNRPE -5176
SNRPF -4734
SNRPG -4164
LSM10 -3008


Signaling by Activin

Signaling by Activin
1166
set Signaling by Activin
setSize 15
pANOVA 0.00033
s.dist -0.535
p.adjustANOVA 0.00166



Top enriched genes

Top 20 genes
GeneID Gene Rank
INHBA -12105
DRAP1 -11977
MAPK3 -10361
FSTL3 -9828
MAPK1 -9787
FST -9229
SMAD2 -9171
ACVR2A -8433
SMAD4 -8385
ACVR1B -7441
SMAD3 -5929
ACVR2B -5189
INHBB -4899
FOXH1 6155
ACVR1C 11598

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INHBA -12105
DRAP1 -11977
MAPK3 -10361
FSTL3 -9828
MAPK1 -9787
FST -9229
SMAD2 -9171
ACVR2A -8433
SMAD4 -8385
ACVR1B -7441
SMAD3 -5929
ACVR2B -5189
INHBB -4899
FOXH1 6155
ACVR1C 11598


Mitophagy

Mitophagy
710
set Mitophagy
setSize 28
pANOVA 1.15e-06
s.dist -0.531
p.adjustANOVA 1.16e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC -12015
TOMM5 -11478
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
UBC -11024
TOMM22 -10580
CSNK2A2 -10568
MAP1LC3B -10436
PINK1 -10350
SQSTM1 -10076
MAP1LC3A -10048
CSNK2B -9864
TOMM6 -9737
MFN2 -9248
ATG5 -8156
UBA52 -7355
MTERF3 -7267
UBB -6063
TOMM40 -5710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC -12015
TOMM5 -11478
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
UBC -11024
TOMM22 -10580
CSNK2A2 -10568
MAP1LC3B -10436
PINK1 -10350
SQSTM1 -10076
MAP1LC3A -10048
CSNK2B -9864
TOMM6 -9737
MFN2 -9248
ATG5 -8156
UBA52 -7355
MTERF3 -7267
UBB -6063
TOMM40 -5710
ATG12 -4960
FUNDC1 -3325
TOMM20 -2687
TOMM7 1305
TOMM70 2169
RPS27A 5458
MFN1 9758
VDAC1 10424


Response of EIF2AK1 (HRI) to heme deficiency

Response of EIF2AK1 (HRI) to heme deficiency
1086
set Response of EIF2AK1 (HRI) to heme deficiency
setSize 15
pANOVA 0.000501
s.dist -0.519
p.adjustANOVA 0.00238



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP1R15A -11685
ASNS -11505
EIF2S2 -11280
EIF2S3 -10799
CEBPG -10559
DDIT3 -10011
EIF2S1 -9559
GRB10 -7819
CEBPB -7684
ATF4 -7315
ATF3 -4410
TRIB3 -3462
ATF5 -2836
EIF2AK1 7124
CHAC1 9936

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1R15A -11685
ASNS -11505
EIF2S2 -11280
EIF2S3 -10799
CEBPG -10559
DDIT3 -10011
EIF2S1 -9559
GRB10 -7819
CEBPB -7684
ATF4 -7315
ATF3 -4410
TRIB3 -3462
ATF5 -2836
EIF2AK1 7124
CHAC1 9936


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
55
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 58
pANOVA 8.03e-12
s.dist -0.519
p.adjustANOVA 3.03e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF4EBP1 -12052
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
EIF2S1 -9559
EIF3C -9450

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF4EBP1 -12052
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
EIF2S1 -9559
EIF3C -9450
RPS9 -9422
RPS15A -9361
FAU -9217
RPS4X -9149
RPS10 -8990
EIF4A1 -8756
EIF3H -8709
EIF3I -8493
RPS12 -8467
RPS3 -8350
RPS11 -8319
EIF3G -8248
RPS19 -8226
RPS15 -8015
PABPC1 -7595
RPS5 -6800
RPS8 -6290
EIF1AX -5932
EIF3A -5666
RPS20 -5374
EIF3J -5231
EIF3B -5180
RPS16 -4149
RPS21 -3225
EIF3K -2857
RPS26 -2804
EIF3F -1420
RPS14 -1250
RPS29 -684
RPSA 306
RPS27 679
RPS24 2437
RPS28 2787
RPS7 5242
RPS27A 5458
RPS23 7043
RPS27L 7433
EIF4G1 9262


Hyaluronan uptake and degradation

Hyaluronan uptake and degradation
538
set Hyaluronan uptake and degradation
setSize 10
pANOVA 0.00477
s.dist 0.515
p.adjustANOVA 0.0167



Top enriched genes

Top 20 genes
GeneID Gene Rank
HEXA 12529
CHP1 10937
GUSB 9533
SLC9A1 8344
CD44 7147
HYAL2 7132
HMMR 6234
HYAL1 4893
HEXB 1828
HYAL3 445

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HEXA 12529
CHP1 10937
GUSB 9533
SLC9A1 8344
CD44 7147
HYAL2 7132
HMMR 6234
HYAL1 4893
HEXB 1828
HYAL3 445


Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
572
set Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
setSize 22
pANOVA 3.12e-05
s.dist -0.513
p.adjustANOVA 0.000219



Top enriched genes

Top 20 genes
GeneID Gene Rank
HMOX1 -11813
STX1A -11406
EMD -10841
VAPA -10722
STX5 -10504
BAG6 -10318
SERP1 -9958
UBL4A -9686
CAMLG -9613
SGTA -8988
SEC61B -8872
PRNP -8739
GET4 -8088
SEC61G -7573
VAMP2 -5911
GET3 -5743
GET1 -5214
UBE2J2 -3854
OTOF 748
ALDH3A2 5532

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HMOX1 -11813
STX1A -11406
EMD -10841
VAPA -10722
STX5 -10504
BAG6 -10318
SERP1 -9958
UBL4A -9686
CAMLG -9613
SGTA -8988
SEC61B -8872
PRNP -8739
GET4 -8088
SEC61G -7573
VAMP2 -5911
GET3 -5743
GET1 -5214
UBE2J2 -3854
OTOF 748
ALDH3A2 5532
CYB5A 6561
APP 12020


Translation initiation complex formation

Translation initiation complex formation
1376
set Translation initiation complex formation
setSize 57
pANOVA 2.55e-11
s.dist -0.51
p.adjustANOVA 8.17e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
EIF2S1 -9559
EIF3C -9450
RPS9 -9422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
EIF2S1 -9559
EIF3C -9450
RPS9 -9422
RPS15A -9361
FAU -9217
RPS4X -9149
RPS10 -8990
EIF4A1 -8756
EIF3H -8709
EIF3I -8493
RPS12 -8467
RPS3 -8350
RPS11 -8319
EIF3G -8248
RPS19 -8226
RPS15 -8015
PABPC1 -7595
RPS5 -6800
RPS8 -6290
EIF1AX -5932
EIF3A -5666
RPS20 -5374
EIF3J -5231
EIF3B -5180
RPS16 -4149
RPS21 -3225
EIF3K -2857
RPS26 -2804
EIF3F -1420
RPS14 -1250
RPS29 -684
RPSA 306
RPS27 679
RPS24 2437
RPS28 2787
RPS7 5242
RPS27A 5458
RPS23 7043
RPS27L 7433
EIF4G1 9262


Lysosphingolipid and LPA receptors

Lysosphingolipid and LPA receptors
644
set Lysosphingolipid and LPA receptors
setSize 12
pANOVA 0.00241
s.dist -0.506
p.adjustANOVA 0.00922



Top enriched genes

Top 20 genes
GeneID Gene Rank
PLPPR3 -10723
LPAR1 -10266
S1PR2 -10033
LPAR3 -9311
S1PR5 -7898
S1PR3 -7624
LPAR2 -7023
LPAR5 -5649
PLPPR4 -2974
PLPPR5 -2033
S1PR1 -1606
PLPPR2 3603

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLPPR3 -10723
LPAR1 -10266
S1PR2 -10033
LPAR3 -9311
S1PR5 -7898
S1PR3 -7624
LPAR2 -7023
LPAR5 -5649
PLPPR4 -2974
PLPPR5 -2033
S1PR1 -1606
PLPPR2 3603


rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
1462
set rRNA modification in the nucleus and cytosol
setSize 60
pANOVA 1.68e-11
s.dist -0.502
p.adjustANOVA 5.49e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
RCL1 -11986
WDR75 -11967
IMP4 -11676
UTP11 -11160
NOP2 -11154
THUMPD1 -10954
SNU13 -10937
RPS2 -10847
DCAF13 -10822
NOP14 -10791
UTP18 -10509
WDR46 -10471
NOL6 -10442
NOP58 -10338
TBL3 -10336
NAT10 -10031
DIMT1 -9904
RPS6 -9840
DKC1 -9637
FBL -9623

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RCL1 -11986
WDR75 -11967
IMP4 -11676
UTP11 -11160
NOP2 -11154
THUMPD1 -10954
SNU13 -10937
RPS2 -10847
DCAF13 -10822
NOP14 -10791
UTP18 -10509
WDR46 -10471
NOL6 -10442
NOP58 -10338
TBL3 -10336
NAT10 -10031
DIMT1 -9904
RPS6 -9840
DKC1 -9637
FBL -9623
UTP6 -9612
GAR1 -9567
TSR3 -9540
RPS9 -9422
WDR43 -9225
EMG1 -9140
PDCD11 -9070
WDR3 -8511
RRP9 -7747
NOP56 -7729
DDX49 -7500
DHX37 -7406
NOC4L -7253
UTP4 -7019
MPHOSPH10 -6698
RRP36 -6552
TRMT112 -6214
SNORD3A -5958
DDX52 -5369
UTP3 -4338
PNO1 -3714
NOL11 -3467
DDX47 -3266
UTP15 -3063
PWP2 -3059
HEATR1 -2462
RRP7A -2448
UTP25 -2260
KRR1 -1550
RPS14 -1250
NHP2 -229
FCF1 737
WDR36 2180
BMS1 2244
NOP10 2837
UTP14C 4272
RPS7 5242
UTP14A 6235
UTP20 7593
IMP3 8618


HIV elongation arrest and recovery

HIV elongation arrest and recovery
517
set HIV elongation arrest and recovery
setSize 32
pANOVA 9.16e-07
s.dist -0.501
p.adjustANOVA 9.56e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CCNK -8869
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CCNK -8869
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
CCNT2 -7458
ELOA -6230
POLR2I -6204
POLR2G -6092
POLR2E -5082
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
SUPT16H 10173
POLR2L 12269


Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation
848
set Pausing and recovery of HIV elongation
setSize 32
pANOVA 9.16e-07
s.dist -0.501
p.adjustANOVA 9.56e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CCNK -8869
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CCNK -8869
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
CCNT2 -7458
ELOA -6230
POLR2I -6204
POLR2G -6092
POLR2E -5082
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
SUPT16H 10173
POLR2L 12269


SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs
1116
set SLBP independent Processing of Histone Pre-mRNAs
setSize 10
pANOVA 0.0061
s.dist -0.501
p.adjustANOVA 0.0209



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZNF473 -8727
NCBP1 -8378
NCBP2 -6900
LSM11 -6545
SNRPD3 -6094
SNRPB -5246
SNRPE -5176
SNRPF -4734
SNRPG -4164
LSM10 -3008

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZNF473 -8727
NCBP1 -8378
NCBP2 -6900
LSM11 -6545
SNRPD3 -6094
SNRPB -5246
SNRPE -5176
SNRPF -4734
SNRPG -4164
LSM10 -3008


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
429
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 50
pANOVA 1.07e-09
s.dist -0.498
p.adjustANOVA 2.76e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
RPS2 -10847
EIF2S3 -10799
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF2S1 -9559
EIF3C -9450
RPS9 -9422
RPS15A -9361
FAU -9217
RPS4X -9149
RPS10 -8990

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
RPS2 -10847
EIF2S3 -10799
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF2S1 -9559
EIF3C -9450
RPS9 -9422
RPS15A -9361
FAU -9217
RPS4X -9149
RPS10 -8990
EIF3H -8709
EIF3I -8493
RPS12 -8467
RPS3 -8350
RPS11 -8319
EIF3G -8248
RPS19 -8226
RPS15 -8015
RPS5 -6800
RPS8 -6290
EIF1AX -5932
EIF3A -5666
RPS20 -5374
EIF3J -5231
EIF3B -5180
RPS16 -4149
RPS21 -3225
EIF3K -2857
RPS26 -2804
EIF3F -1420
RPS14 -1250
RPS29 -684
RPSA 306
RPS27 679
RPS24 2437
RPS28 2787
RPS7 5242
RPS27A 5458
RPS23 7043
RPS27L 7433


Protein methylation

Protein methylation
916
set Protein methylation
setSize 15
pANOVA 0.000968
s.dist -0.492
p.adjustANOVA 0.00413



Top enriched genes

Top 20 genes
GeneID Gene Rank
ETFB -11539
HSPA8 -11386
VCP -11298
RPS2 -10847
EEF1A1 -10377
PRMT3 -8703
METTL22 -8180
EEF2KMT -8024
METTL21A -7187
EEF2 -6940
VCPKMT -6040
CAMKMT -4009
KIN 1531
ETFBKMT 4791
CALM1 11432

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ETFB -11539
HSPA8 -11386
VCP -11298
RPS2 -10847
EEF1A1 -10377
PRMT3 -8703
METTL22 -8180
EEF2KMT -8024
METTL21A -7187
EEF2 -6940
VCPKMT -6040
CAMKMT -4009
KIN 1531
ETFBKMT 4791
CALM1 11432


TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex
1296
set TICAM1,TRAF6-dependent induction of TAK1 complex
setSize 11
pANOVA 0.00489
s.dist -0.49
p.adjustANOVA 0.0171



Top enriched genes

Top 20 genes
GeneID Gene Rank
TICAM1 -11202
UBC -11024
TAB3 -10903
TRAF6 -10448
UBA52 -7355
UBB -6063
TAB2 -5482
TAB1 -5261
MAP3K7 -4381
TLR3 3299
RPS27A 5458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TICAM1 -11202
UBC -11024
TAB3 -10903
TRAF6 -10448
UBA52 -7355
UBB -6063
TAB2 -5482
TAB1 -5261
MAP3K7 -4381
TLR3 3299
RPS27A 5458


Deadenylation of mRNA

Deadenylation of mRNA
260
set Deadenylation of mRNA
setSize 22
pANOVA 7.05e-05
s.dist -0.489
p.adjustANOVA 0.000447



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNKS1BP1 -12129
CNOT7 -11928
PARN -11180
EIF4E -10908
CNOT3 -10808
EIF4A2 -10418
CNOT10 -9929
CNOT11 -9747
EIF4B -9615
CNOT8 -9272
PAIP1 -9033
CNOT6L -8963
EIF4A1 -8756
PABPC1 -7595
PAN3 -5331
PAN2 -5141
CNOT4 -2474
EIF4A3 -659
CNOT1 2604
CNOT6 4445

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNKS1BP1 -12129
CNOT7 -11928
PARN -11180
EIF4E -10908
CNOT3 -10808
EIF4A2 -10418
CNOT10 -9929
CNOT11 -9747
EIF4B -9615
CNOT8 -9272
PAIP1 -9033
CNOT6L -8963
EIF4A1 -8756
PABPC1 -7595
PAN3 -5331
PAN2 -5141
CNOT4 -2474
EIF4A3 -659
CNOT1 2604
CNOT6 4445
EIF4G1 9262
CNOT2 11053


Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation
849
set Pausing and recovery of Tat-mediated HIV elongation
setSize 30
pANOVA 3.5e-06
s.dist -0.489
p.adjustANOVA 3.03e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
ELOA -6230
POLR2I -6204
POLR2G -6092
POLR2E -5082
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
SUPT16H 10173
POLR2L 12269


Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery
1322
set Tat-mediated HIV elongation arrest and recovery
setSize 30
pANOVA 3.5e-06
s.dist -0.489
p.adjustANOVA 3.03e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
POLR2D -9853
TCEA1 -9759
POLR2F -9509
SSRP1 -9242
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
ELOA -6230
POLR2I -6204
POLR2G -6092
POLR2E -5082
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
SUPT16H 10173
POLR2L 12269


PERK regulates gene expression

PERK regulates gene expression
821
set PERK regulates gene expression
setSize 32
pANOVA 1.83e-06
s.dist -0.487
p.adjustANOVA 1.76e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ASNS -11505
NFYA -11413
EIF2S2 -11280
PARN -11180
EIF2S3 -10799
CEBPG -10559
EXOSC3 -10243
DDIT3 -10011
EXOSC7 -9758
CCL2 -9580
EIF2S1 -9559
KHSRP -9466
EXOSC5 -9069
DCP2 -7876
CEBPB -7684
DIS3 -7630
ATF4 -7315
EXOSC2 -6863
HSPA5 -6732
NFYB -6415

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ASNS -11505
NFYA -11413
EIF2S2 -11280
PARN -11180
EIF2S3 -10799
CEBPG -10559
EXOSC3 -10243
DDIT3 -10011
EXOSC7 -9758
CCL2 -9580
EIF2S1 -9559
KHSRP -9466
EXOSC5 -9069
DCP2 -7876
CEBPB -7684
DIS3 -7630
ATF4 -7315
EXOSC2 -6863
HSPA5 -6732
NFYB -6415
EXOSC4 -6221
EXOSC8 -6069
EXOSC6 -5196
CXCL8 -4823
ATF3 -4410
NFYC -3596
HERPUD1 -275
EIF2AK3 2165
EXOSC9 2580
EXOSC1 5717
ATF6 9080
IGFBP1 12936


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1094
set Ribosomal scanning and start codon recognition
setSize 57
pANOVA 2.24e-10
s.dist -0.485
p.adjustANOVA 6.48e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
EIF2S1 -9559
EIF3C -9450
RPS9 -9422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPS13 -10067
RPS25 -9987
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
EIF2S1 -9559
EIF3C -9450
RPS9 -9422
RPS15A -9361
FAU -9217
RPS4X -9149
RPS10 -8990
EIF4A1 -8756
EIF3H -8709
EIF3I -8493
RPS12 -8467
RPS3 -8350
RPS11 -8319
EIF3G -8248
RPS19 -8226
RPS15 -8015
RPS5 -6800
RPS8 -6290
EIF1AX -5932
EIF3A -5666
RPS20 -5374
EIF3J -5231
EIF3B -5180
RPS16 -4149
RPS21 -3225
EIF3K -2857
RPS26 -2804
EIF3F -1420
RPS14 -1250
RPS29 -684
RPSA 306
RPS27 679
RPS24 2437
RPS28 2787
RPS7 5242
RPS27A 5458
RPS23 7043
RPS27L 7433
EIF4G1 9262
EIF5 10306


Hyaluronan metabolism

Hyaluronan metabolism
537
set Hyaluronan metabolism
setSize 14
pANOVA 0.00174
s.dist 0.483
p.adjustANOVA 0.00698



Top enriched genes

Top 20 genes
GeneID Gene Rank
CEMIP 12965
HEXA 12529
HAS3 11642
CHP1 10937
GUSB 9533
ABCC5 9531
SLC9A1 8344
CD44 7147
HYAL2 7132
HMMR 6234
HYAL1 4893
HEXB 1828
HYAL3 445
HAS2 -12188

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CEMIP 12965
HEXA 12529
HAS3 11642
CHP1 10937
GUSB 9533
ABCC5 9531
SLC9A1 8344
CD44 7147
HYAL2 7132
HMMR 6234
HYAL1 4893
HEXB 1828
HYAL3 445
HAS2 -12188


Josephin domain DUBs

Josephin domain DUBs
617
set Josephin domain DUBs
setSize 10
pANOVA 0.00831
s.dist -0.482
p.adjustANOVA 0.027



Top enriched genes

Top 20 genes
GeneID Gene Rank
VCP -11298
JOSD1 -11235
UBC -11024
ATXN3 -9324
RAD23B -7960
UBA52 -7355
UBB -6063
RAD23A -5286
RPS27A 5458
JOSD2 7490

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VCP -11298
JOSD1 -11235
UBC -11024
ATXN3 -9324
RAD23B -7960
UBA52 -7355
UBB -6063
RAD23A -5286
RPS27A 5458
JOSD2 7490


ROS sensing by NFE2L2

ROS sensing by NFE2L2
997
set ROS sensing by NFE2L2
setSize 55
pANOVA 6.27e-10
s.dist -0.482
p.adjustANOVA 1.74e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
NFE2L2 -11721
CUL3 -11425
PSMD14 -11242
CSNK2A1 -11231
PSME4 -11208
UBC -11024
PSMA7 -10789
SEM1 -10597
CSNK2A2 -10568
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
RBX1 -9931
CSNK2B -9864
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PSMB7 -9263

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NFE2L2 -11721
CUL3 -11425
PSMD14 -11242
CSNK2A1 -11231
PSME4 -11208
UBC -11024
PSMA7 -10789
SEM1 -10597
CSNK2A2 -10568
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
RBX1 -9931
CSNK2B -9864
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PSMB7 -9263
PSME1 -9261
PSMD3 -8656
PSMD9 -8231
PSMD6 -8169
PSMF1 -8140
PSMC4 -7727
PSMC6 -7633
PSMB5 -7489
PSMD10 -7419
UBA52 -7355
PSMD2 -7349
PSMB6 -7067
PSMD7 -6706
PSMB1 -6644
PSMA3 -6131
UBB -6063
PSMD13 -5738
PRKCD -4707
PSME2 -4577
KEAP1 -4517
PSMA2 -4323
PSMC1 -3828
PSMB2 -3623
PSMA6 -3583
PSMB4 -1449
PSMC3 -1344
PSMD4 774
PSMD12 846
RPS27A 5458
PSMA5 5639
PSMC5 7127
PSMD11 7823
PSMB3 8008
PSMB10 9640
PSME3 11914


Nucleotide biosynthesis

Nucleotide biosynthesis
798
set Nucleotide biosynthesis
setSize 12
pANOVA 0.00387
s.dist -0.482
p.adjustANOVA 0.0139



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATIC -11566
GART -11514
PPAT -10725
IMPDH2 -9672
PAICS -9504
IMPDH1 -9283
CAD -8582
ADSL -7668
GMPS -4747
UMPS -2534
DHODH 7463
PFAS 10473

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATIC -11566
GART -11514
PPAT -10725
IMPDH2 -9672
PAICS -9504
IMPDH1 -9283
CAD -8582
ADSL -7668
GMPS -4747
UMPS -2534
DHODH 7463
PFAS 10473


Spry regulation of FGF signaling

Spry regulation of FGF signaling
1254
set Spry regulation of FGF signaling
setSize 16
pANOVA 0.000895
s.dist -0.48
p.adjustANOVA 0.00386



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC -12015
PPP2CB -12001
UBC -11024
MAPK3 -10361
CBL -9932
PPP2R1A -9808
MAPK1 -9787
PTPN11 -7428
UBA52 -7355
GRB2 -6642
SPRY2 -6481
UBB -6063
PPP2CA -3355
RPS27A 5458
BRAF 8079
MKNK1 8665

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC -12015
PPP2CB -12001
UBC -11024
MAPK3 -10361
CBL -9932
PPP2R1A -9808
MAPK1 -9787
PTPN11 -7428
UBA52 -7355
GRB2 -6642
SPRY2 -6481
UBB -6063
PPP2CA -3355
RPS27A 5458
BRAF 8079
MKNK1 8665


Formation of HIV elongation complex in the absence of HIV Tat

Formation of HIV elongation complex in the absence of HIV Tat
417
set Formation of HIV elongation complex in the absence of HIV Tat
setSize 44
pANOVA 4.82e-08
s.dist -0.475
p.adjustANOVA 9.47e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
CCNK -8869
NCBP1 -8378
CTDP1 -8346
ELOC -7977

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
CCNK -8869
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
CCNT2 -7458
CCNH -7329
ERCC2 -6960
NCBP2 -6900
ELOA -6230
POLR2I -6204
GTF2H2 -6113
POLR2G -6092
GTF2H5 -5258
POLR2E -5082
MNAT1 -4688
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
GTF2H4 8518
SUPT16H 10173
GTF2H3 10709
POLR2L 12269


Formation of HIV-1 elongation complex containing HIV-1 Tat

Formation of HIV-1 elongation complex containing HIV-1 Tat
418
set Formation of HIV-1 elongation complex containing HIV-1 Tat
setSize 42
pANOVA 1.77e-07
s.dist -0.465
p.adjustANOVA 2.64e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
CCNH -7329
ERCC2 -6960
NCBP2 -6900
ELOA -6230
POLR2I -6204
GTF2H2 -6113
POLR2G -6092
GTF2H5 -5258
POLR2E -5082
MNAT1 -4688
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
GTF2H4 8518
SUPT16H 10173
GTF2H3 10709
POLR2L 12269


HIV Transcription Elongation

HIV Transcription Elongation
515
set HIV Transcription Elongation
setSize 42
pANOVA 1.77e-07
s.dist -0.465
p.adjustANOVA 2.64e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
CCNH -7329
ERCC2 -6960
NCBP2 -6900
ELOA -6230
POLR2I -6204
GTF2H2 -6113
POLR2G -6092
GTF2H5 -5258
POLR2E -5082
MNAT1 -4688
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
GTF2H4 8518
SUPT16H 10173
GTF2H3 10709
POLR2L 12269


Tat-mediated elongation of the HIV-1 transcript

Tat-mediated elongation of the HIV-1 transcript
1323
set Tat-mediated elongation of the HIV-1 transcript
setSize 42
pANOVA 1.77e-07
s.dist -0.465
p.adjustANOVA 2.64e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
ELL -11410
CCNT1 -11239
NELFA -11134
ERCC3 -10404
POLR2B -10329
ELOB -10320
NELFCD -10185
POLR2C -10068
CDK7 -10058
POLR2D -9853
TCEA1 -9759
POLR2F -9509
GTF2H1 -9432
SSRP1 -9242
NCBP1 -8378
CTDP1 -8346
ELOC -7977
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
CDK9 -7460
CCNH -7329
ERCC2 -6960
NCBP2 -6900
ELOA -6230
POLR2I -6204
GTF2H2 -6113
POLR2G -6092
GTF2H5 -5258
POLR2E -5082
MNAT1 -4688
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
GTF2H4 8518
SUPT16H 10173
GTF2H3 10709
POLR2L 12269


ATF4 activates genes in response to endoplasmic reticulum stress

ATF4 activates genes in response to endoplasmic reticulum stress
19
set ATF4 activates genes in response to endoplasmic reticulum stress
setSize 27
pANOVA 2.91e-05
s.dist -0.465
p.adjustANOVA 0.000205



Top enriched genes

Top 20 genes
GeneID Gene Rank
ASNS -11505
NFYA -11413
PARN -11180
CEBPG -10559
EXOSC3 -10243
DDIT3 -10011
EXOSC7 -9758
CCL2 -9580
KHSRP -9466
EXOSC5 -9069
DCP2 -7876
CEBPB -7684
DIS3 -7630
ATF4 -7315
EXOSC2 -6863
NFYB -6415
EXOSC4 -6221
EXOSC8 -6069
EXOSC6 -5196
CXCL8 -4823

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ASNS -11505
NFYA -11413
PARN -11180
CEBPG -10559
EXOSC3 -10243
DDIT3 -10011
EXOSC7 -9758
CCL2 -9580
KHSRP -9466
EXOSC5 -9069
DCP2 -7876
CEBPB -7684
DIS3 -7630
ATF4 -7315
EXOSC2 -6863
NFYB -6415
EXOSC4 -6221
EXOSC8 -6069
EXOSC6 -5196
CXCL8 -4823
ATF3 -4410
NFYC -3596
HERPUD1 -275
EXOSC9 2580
EXOSC1 5717
ATF6 9080
IGFBP1 12936


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
624
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 109
pANOVA 5.4e-17
s.dist -0.464
p.adjustANOVA 5.3e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
RPL22L1 -11075
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPL10A -10326
RPL9 -10276
RPS13 -10067
RPL26L1 -10003
RPS25 -9987
RPL34 -9972
RPL37A -9962
RPL12 -9944
RPS6 -9840
RPS3A -9784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF4H -11594
EIF3M -11345
EIF2S2 -11280
RPS17 -11161
RPL22L1 -11075
EIF3D -11027
EIF4E -10908
RPS2 -10847
EIF2S3 -10799
EIF4A2 -10418
RPL10A -10326
RPL9 -10276
RPS13 -10067
RPL26L1 -10003
RPS25 -9987
RPL34 -9972
RPL37A -9962
RPL12 -9944
RPS6 -9840
RPS3A -9784
EIF3L -9774
RPS18 -9734
EIF3E -9682
EIF4B -9615
RPL17 -9599
EIF2S1 -9559
EIF3C -9450
RPL36 -9425
RPS9 -9422
RPL26 -9404
RPL31 -9388
RPS15A -9361
FAU -9217
RPS4X -9149
RPL11 -9136
RPS10 -8990
RPLP2 -8827
RPL36AL -8817
EIF4A1 -8756
EIF3H -8709
RPL35 -8625
EIF3I -8493
RPS12 -8467
RPL27A -8412
RPS3 -8350
RPS11 -8319
EIF3G -8248
RPS19 -8226
RPL8 -8164
RPS15 -8015
PABPC1 -7595
RPL18A -7530
RPL6 -7455
RPL13A -7403
RPL3 -7375
UBA52 -7355
RPL18 -7207
RPL39L -7141
RPL14 -6909
RPL21 -6840
RPS5 -6800
RPL39 -6675
RPL7A -6670
RPS8 -6290
RPL28 -6287
RPL22 -6014
EIF1AX -5932
EIF3A -5666
RPL32 -5445
RPS20 -5374
EIF3J -5231
EIF3B -5180
RPL37 -5004
RPL41 -4994
RPL24 -4966
RPL29 -4883
RPL36A -4846
RPL30 -4218
RPS16 -4149
RPL10 -4126
RPL13 -3746
RPL7 -3582
RPS21 -3225
EIF3K -2857
RPS26 -2804
RPLP0 -1594
RPL35A -1535
EIF3F -1420
RPS14 -1250
RPL15 -826
RPS29 -684
RPL3L -537
RPSA 306
RPS27 679
RPL38 1610
RPS24 2437
RPS28 2787
RPL19 4011
RPL5 4778
RPS7 5242
RPS27A 5458
RPL23 5870
RPL27 6838
RPS23 7043
RPS27L 7433
RPLP1 9129
EIF4G1 9262
RPL4 11454
RPL23A 11464


FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes
401
set FOXO-mediated transcription of cell death genes
setSize 15
pANOVA 0.00186
s.dist -0.464
p.adjustANOVA 0.0074



Top enriched genes

Top 20 genes
GeneID Gene Rank
NFYA -11413
BCL2L11 -11391
CREBBP -11014
FOXO3 -10569
PINK1 -10350
EP300 -10088
DDIT3 -10011
STK11 -9001
NFYB -6415
BBC3 -6232
BCL6 -4463
NFYC -3596
FOXO4 7499
CITED2 7513
FOXO1 8048

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NFYA -11413
BCL2L11 -11391
CREBBP -11014
FOXO3 -10569
PINK1 -10350
EP300 -10088
DDIT3 -10011
STK11 -9001
NFYB -6415
BBC3 -6232
BCL6 -4463
NFYC -3596
FOXO4 7499
CITED2 7513
FOXO1 8048


DNA strand elongation

DNA strand elongation
257
set DNA strand elongation
setSize 32
pANOVA 5.53e-06
s.dist 0.464
p.adjustANOVA 4.62e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM2 12397
MCM3 12395
RFC5 12353
MCM4 12297
POLD4 11622
MCM8 11539
GINS4 11393
MCM5 11361
GINS2 11349
GINS1 11143
POLD1 10933
RPA3 10692
FEN1 10426
CDC45 10334
POLD2 10275
PRIM1 9683
GINS3 9584
DNA2 9285
PCNA 9270
LIG1 8972

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM2 12397
MCM3 12395
RFC5 12353
MCM4 12297
POLD4 11622
MCM8 11539
GINS4 11393
MCM5 11361
GINS2 11349
GINS1 11143
POLD1 10933
RPA3 10692
FEN1 10426
CDC45 10334
POLD2 10275
PRIM1 9683
GINS3 9584
DNA2 9285
PCNA 9270
LIG1 8972
POLA1 8347
RFC3 8052
RFC4 7757
PRIM2 6325
POLA2 5446
POLD3 -3904
RFC2 -4546
RPA2 -6512
MCM7 -7516
RFC1 -9407
MCM6 -9875
RPA1 -11466


Abortive elongation of HIV-1 transcript in the absence of Tat

Abortive elongation of HIV-1 transcript in the absence of Tat
28
set Abortive elongation of HIV-1 transcript in the absence of Tat
setSize 23
pANOVA 0.000127
s.dist -0.462
p.adjustANOVA 0.000732



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
NELFA -11134
POLR2B -10329
NELFCD -10185
POLR2C -10068
POLR2D -9853
POLR2F -9509
NCBP1 -8378
CTDP1 -8346
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
NCBP2 -6900
POLR2I -6204
POLR2G -6092
POLR2E -5082
NELFE -3770
POLR2H 7362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973
SUPT5H -11494
NELFA -11134
POLR2B -10329
NELFCD -10185
POLR2C -10068
POLR2D -9853
POLR2F -9509
NCBP1 -8378
CTDP1 -8346
GTF2F1 -7816
GTF2F2 -7751
NELFB -7562
POLR2J -7484
NCBP2 -6900
POLR2I -6204
POLR2G -6092
POLR2E -5082
NELFE -3770
POLR2H 7362
SUPT4H1 7877
POLR2K 8218
POLR2L 12269


Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
414
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.0119
s.dist -0.459
p.adjustANOVA 0.0364



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCT5 -11857
CCT8 -11545
TCP1 -11094
CCT2 -10660
CCT6A -10000
CCT4 -9256
CCT7 -6911
CCT6B 367
CCT3 6847
ACTB 10353

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT5 -11857
CCT8 -11545
TCP1 -11094
CCT2 -10660
CCT6A -10000
CCT4 -9256
CCT7 -6911
CCT6B 367
CCT3 6847
ACTB 10353


Regulation of RUNX3 expression and activity

Regulation of RUNX3 expression and activity
1043
set Regulation of RUNX3 expression and activity
setSize 54
pANOVA 6.91e-09
s.dist -0.456
p.adjustANOVA 1.64e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC -12015
SMURF1 -11912
PSMD14 -11242
UBC -11024
PSMA7 -10789
RUNX3 -10659
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
EP300 -10088
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PSMB7 -9263
PSME1 -9261
PSMD3 -8656
PSMD9 -8231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC -12015
SMURF1 -11912
PSMD14 -11242
UBC -11024
PSMA7 -10789
RUNX3 -10659
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
EP300 -10088
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PSMB7 -9263
PSME1 -9261
PSMD3 -8656
PSMD9 -8231
PSMD6 -8169
CBFB -8160
PSMF1 -8140
PSMC4 -7727
PSMC6 -7633
PSMB5 -7489
PSMD10 -7419
UBA52 -7355
PSMD2 -7349
PSMB6 -7067
PSMD7 -6706
PSMB1 -6644
PSMA3 -6131
UBB -6063
PSMD13 -5738
PSME2 -4577
PSMA2 -4323
PSMC1 -3828
TGFB1 -3807
MDM2 -3649
PSMB2 -3623
PSMA6 -3583
PSMB4 -1449
SMURF2 -1426
PSMC3 -1344
PSMD4 774
PSMD12 846
RPS27A 5458
PSMA5 5639
PSMC5 7127
PSMD11 7823
PSMB3 8008
PSMB10 9640
PSME3 11914


Regulation of PTEN mRNA translation

Regulation of PTEN mRNA translation
1038
set Regulation of PTEN mRNA translation
setSize 12
pANOVA 0.00662
s.dist -0.453
p.adjustANOVA 0.0222



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGO2 -11451
TNRC6B -11300
VAPA -10722
AGO3 -10535
CNOT6L -8963
AGO1 -8274
PTENP1 -7709
PTEN -7485
TNRC6C -5453
TNRC6A 2975
MOV10 6768
AGO4 8669

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGO2 -11451
TNRC6B -11300
VAPA -10722
AGO3 -10535
CNOT6L -8963
AGO1 -8274
PTENP1 -7709
PTEN -7485
TNRC6C -5453
TNRC6A 2975
MOV10 6768
AGO4 8669


mRNA decay by 5’ to 3’ exoribonuclease

mRNA decay by 5’ to 3’ exoribonuclease
1450
set mRNA decay by 5’ to 3’ exoribonuclease
setSize 15
pANOVA 0.00246
s.dist -0.452
p.adjustANOVA 0.00937



Top enriched genes

Top 20 genes
GeneID Gene Rank
PATL1 -11200
LSM2 -10658
LSM1 -10498
DDX6 -10279
DCP1A -9444
LSM7 -9357
EDC4 -8269
DCP2 -7876
LSM6 -7679
LSM3 -4520
LSM5 -4123
LSM4 -2397
XRN1 3558
DCP1B 4249
EDC3 9348

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PATL1 -11200
LSM2 -10658
LSM1 -10498
DDX6 -10279
DCP1A -9444
LSM7 -9357
EDC4 -8269
DCP2 -7876
LSM6 -7679
LSM3 -4520
LSM5 -4123
LSM4 -2397
XRN1 3558
DCP1B 4249
EDC3 9348


rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
1465
set rRNA processing in the nucleus and cytosol
setSize 190
pANOVA 8.93e-27
s.dist -0.45
p.adjustANOVA 3.29e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RCL1 -11986
WDR75 -11967
TSR1 -11823
IMP4 -11676
RBM28 -11528
TEX10 -11313
WDR12 -11221
RRP1 -11191
RPS17 -11161
UTP11 -11160
NOP2 -11154
RPL22L1 -11075
CSNK1E -11072
PELP1 -11043
THUMPD1 -10954
SNU13 -10937
RIOK1 -10870
RPS2 -10847
DCAF13 -10822
NOP14 -10791

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RCL1 -11986
WDR75 -11967
TSR1 -11823
IMP4 -11676
RBM28 -11528
TEX10 -11313
WDR12 -11221
RRP1 -11191
RPS17 -11161
UTP11 -11160
NOP2 -11154
RPL22L1 -11075
CSNK1E -11072
PELP1 -11043
THUMPD1 -10954
SNU13 -10937
RIOK1 -10870
RPS2 -10847
DCAF13 -10822
NOP14 -10791
RPP21 -10768
GNL3 -10678
NOB1 -10572
UTP18 -10509
WDR46 -10471
PES1 -10449
NOL6 -10442
DDX21 -10440
NCL -10410
NOP58 -10338
TBL3 -10336
RPL10A -10326
RPL9 -10276
EXOSC3 -10243
RPS13 -10067
RIOK3 -10062
NAT10 -10031
RPL26L1 -10003
RPS25 -9987
RPL34 -9972
RPL37A -9962
RPL12 -9944
BYSL -9918
DIMT1 -9904
RPS6 -9840
RPS3A -9784
EXOSC7 -9758
RPS18 -9734
DKC1 -9637
FBL -9623
UTP6 -9612
RPL17 -9599
GAR1 -9567
TSR3 -9540
RPL36 -9425
RPS9 -9422
RPL26 -9404
RPL31 -9388
RPS15A -9361
XRN2 -9245
WDR43 -9225
FAU -9217
RPS4X -9149
EMG1 -9140
RPL11 -9136
PDCD11 -9070
EXOSC5 -9069
RPS10 -8990
MTREX -8835
RPLP2 -8827
RPL36AL -8817
RPL35 -8625
NIP7 -8519
WDR3 -8511
RPS12 -8467
RPP40 -8438
LTV1 -8413
RPL27A -8412
BOP1 -8384
RPS3 -8350
RPS11 -8319
RPS19 -8226
RPL8 -8164
RPS15 -8015
RRP9 -7747
NOP56 -7729
DIS3 -7630
RPP14 -7593
ERI1 -7537
RPL18A -7530
DDX49 -7500
RPL6 -7455
DHX37 -7406
RPL13A -7403
RPL3 -7375
UBA52 -7355
RPP38 -7337
NOC4L -7253
RPL18 -7207
RPL39L -7141
UTP4 -7019
RIOK2 -6938
RPL14 -6909
NOL9 -6908
EXOSC2 -6863
RPL21 -6840
RPS5 -6800
SENP3 -6721
MPHOSPH10 -6698
RPL39 -6675
RPL7A -6670
RRP36 -6552
RPS8 -6290
RPL28 -6287
EXOSC4 -6221
TRMT112 -6214
EBNA1BP2 -6202
EXOSC8 -6069
RPL22 -6014
SNORD3A -5958
RPL32 -5445
RPS20 -5374
DDX52 -5369
EXOSC6 -5196
RPL37 -5004
RPL41 -4994
RPL24 -4966
RPL29 -4883
RPL36A -4846
UTP3 -4338
RPL30 -4218
RPS16 -4149
RPL10 -4126
RPL13 -3746
PNO1 -3714
RPL7 -3582
NOL11 -3467
DDX47 -3266
RPS21 -3225
UTP15 -3063
PWP2 -3059
RPS26 -2804
MPHOSPH6 -2601
HEATR1 -2462
RRP7A -2448
UTP25 -2260
RPLP0 -1594
KRR1 -1550
RPL35A -1535
RPS14 -1250
WDR18 -850
RPL15 -826
RPS29 -684
RPL3L -537
NHP2 -229
RPSA 306
RPS27 679
FCF1 737
RPL38 1610
WDR36 2180
BMS1 2244
RPS24 2437
EXOSC9 2580
RPS28 2787
NOP10 2837
RPL19 4011
UTP14C 4272
RPP30 4754
RPL5 4778
C1D 4914
RPS7 5242
RPS27A 5458
NOL12 5621
EXOSC1 5717
RPL23 5870
UTP14A 6235
FTSJ3 6820
RPL27 6838
RPS23 7043
RPS27L 7433
LAS1L 7535
UTP20 7593
IMP3 8618
RPLP1 9129
ISG20L2 9342
CSNK1D 10635
EXOSC10 11426
RPL4 11454
RPL23A 11464
RPP25 12105


Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
195
set Citric acid cycle (TCA cycle)
setSize 22
pANOVA 0.000286
s.dist -0.447
p.adjustANOVA 0.00149



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDH2 -11636
ME2 -11619
MDH2 -11288
SDHA -11107
SDHD -10258
CS -9888
DLD -9868
IDH3A -9507
ME3 -9113
DLST -8794
SUCLG2 -6856
FAHD1 -6804
OGDH -5828
ACO2 -5458
IDH3B -4657
FH -414
SDHB -314
IDH3G 123
SUCLG1 1158
SUCLA2 3403

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDH2 -11636
ME2 -11619
MDH2 -11288
SDHA -11107
SDHD -10258
CS -9888
DLD -9868
IDH3A -9507
ME3 -9113
DLST -8794
SUCLG2 -6856
FAHD1 -6804
OGDH -5828
ACO2 -5458
IDH3B -4657
FH -414
SDHB -314
IDH3G 123
SUCLG1 1158
SUCLA2 3403
NNT 4578
SDHC 9448


KSRP (KHSRP) binds and destabilizes mRNA

KSRP (KHSRP) binds and destabilizes mRNA
618
set KSRP (KHSRP) binds and destabilizes mRNA
setSize 17
pANOVA 0.00147
s.dist -0.446
p.adjustANOVA 0.00603



Top enriched genes

Top 20 genes
GeneID Gene Rank
PARN -11180
EXOSC3 -10243
MAPK14 -10203
EXOSC7 -9758
KHSRP -9466
EXOSC5 -9069
DCP2 -7876
DIS3 -7630
EXOSC2 -6863
EXOSC4 -6221
EXOSC8 -6069
YWHAZ -5875
EXOSC6 -5196
AKT1 -1843
EXOSC9 2580
EXOSC1 5717
MAPK11 10781

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARN -11180
EXOSC3 -10243
MAPK14 -10203
EXOSC7 -9758
KHSRP -9466
EXOSC5 -9069
DCP2 -7876
DIS3 -7630
EXOSC2 -6863
EXOSC4 -6221
EXOSC8 -6069
YWHAZ -5875
EXOSC6 -5196
AKT1 -1843
EXOSC9 2580
EXOSC1 5717
MAPK11 10781


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.9          
##  [49] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       rlang_1.0.2           
##  [55] later_1.3.0            AnnotationDbi_1.54.1   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.0            cachem_1.0.6          
##  [61] cli_3.2.0              generics_0.1.2         RSQLite_2.2.10        
##  [64] broom_0.7.12           evaluate_0.15          fastmap_1.1.0         
##  [67] yaml_2.3.5             knitr_1.37             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.32.0       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.0        
##  [76] rstudioapi_0.13        png_0.1-7              reprex_2.0.1          
##  [79] geneplotter_1.70.0     bslib_0.3.1            stringi_1.7.6         
##  [82] highr_0.9              desc_1.4.1             lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.3.8            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] assertthat_0.2.1       rprojroot_2.0.2        withr_2.5.0           
## [100] GenomeInfoDbData_1.2.6 hms_1.1.1              grid_4.2.0            
## [103] rmarkdown_2.13         shiny_1.7.1            lubridate_1.8.0

END of report