date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA  0.7345726
## 7SK       -2.7733284
## A1BG       0.2830631
## A1BG-AS1  -4.1963792
## A1CF      -0.8548135
## A2M       10.9455668
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2512
num_genes_in_profile 27278
duplicated_genes_present 0
num_profile_genes_in_sets 9132
num_profile_genes_not_in_sets 18146

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2512
num_genesets_excluded 1024
num_genesets_included 1488

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Unwinding of DNA 12 1.01e-05 0.736 6.79e-05
Leading Strand Synthesis 14 2.89e-06 0.722 2.17e-05
Polymerase switching 14 2.89e-06 0.722 2.17e-05
Response to metal ions 10 7.78e-05 0.721 4.52e-04
G1/S-Specific Transcription 29 1.35e-10 0.689 1.79e-09
Condensation of Prometaphase Chromosomes 11 7.92e-05 0.687 4.57e-04
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 2.31e-04 0.672 1.12e-03
Formation of ATP by chemiosmotic coupling 18 9.15e-07 0.668 7.48e-06
SLBP independent Processing of Histone Pre-mRNAs 10 3.22e-04 0.657 1.50e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.69e-04 0.655 8.75e-04
DNA strand elongation 32 1.49e-10 0.654 1.97e-09
Translesion synthesis by REV1 16 9.42e-06 0.640 6.40e-05
Translesion synthesis by POLK 17 5.71e-06 0.635 4.07e-05
Folding of actin by CCT/TriC 10 5.53e-04 0.631 2.45e-03
SCF(Skp2)-mediated degradation of p27/p21 60 4.00e-17 0.627 2.20e-15
The role of GTSE1 in G2/M progression after G2 checkpoint 58 4.32e-16 0.617 1.90e-14
Metabolism of cofactors 19 3.58e-06 0.614 2.65e-05
Regulation of PTEN mRNA translation 12 2.44e-04 -0.612 1.17e-03
Ubiquitin-dependent degradation of Cyclin D 50 9.50e-14 0.608 2.53e-12
Lagging Strand Synthesis 20 2.88e-06 0.604 2.17e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 7.16e-13 0.598 1.50e-11
Removal of the Flap Intermediate 14 1.18e-04 0.594 6.53e-04
Vpu mediated degradation of CD4 50 3.71e-13 0.594 8.30e-12
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.87e-04 -0.591 2.97e-03
Negative regulation of NOTCH4 signaling 54 6.48e-14 0.589 1.79e-12
Hh mutants are degraded by ERAD 54 9.03e-14 0.586 2.44e-12
SCF-beta-TrCP mediated degradation of Emi1 53 1.66e-13 0.585 4.05e-12
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.10e-13 0.583 4.96e-12
HuR (ELAVL1) binds and stabilizes mRNA 10 1.56e-03 0.578 6.11e-03
Regulation of BACH1 activity 11 9.75e-04 0.574 4.10e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 2.48e-12 0.572 4.45e-11
p53-Independent DNA Damage Response 50 2.48e-12 0.572 4.45e-11
p53-Independent G1/S DNA damage checkpoint 50 2.48e-12 0.572 4.45e-11
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 13 3.63e-04 -0.571 1.68e-03
Signaling by FGFR2 IIIa TM 19 1.82e-05 0.568 1.18e-04
Hedgehog ligand biogenesis 63 7.41e-15 0.566 2.45e-13
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.85e-05 0.566 5.01e-04
Purine salvage 12 6.96e-04 0.565 2.99e-03
GLI3 is processed to GLI3R by the proteasome 57 1.58e-13 0.565 3.99e-12
Vif-mediated degradation of APOBEC3G 52 1.92e-12 0.564 3.71e-11
Formation of tubulin folding intermediates by CCT/TriC 23 2.97e-06 0.563 2.22e-05
Hh mutants abrogate ligand secretion 57 2.06e-13 0.562 4.94e-12
Defective CFTR causes cystic fibrosis 58 1.36e-13 0.561 3.48e-12
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.62e-04 0.561 2.08e-03
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.22e-06 0.560 9.83e-06
PCNA-Dependent Long Patch Base Excision Repair 21 8.81e-06 0.560 6.02e-05
NIK–>noncanonical NF-kB signaling 57 2.86e-13 0.559 6.54e-12
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 1.34e-03 0.559 5.37e-03
MASTL Facilitates Mitotic Progression 10 2.25e-03 0.558 8.40e-03
Orc1 removal from chromatin 69 1.12e-15 0.557 4.64e-14


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Unwinding of DNA 12 1.01e-05 7.36e-01 6.79e-05
Leading Strand Synthesis 14 2.89e-06 7.22e-01 2.17e-05
Polymerase switching 14 2.89e-06 7.22e-01 2.17e-05
Response to metal ions 10 7.78e-05 7.21e-01 4.52e-04
G1/S-Specific Transcription 29 1.35e-10 6.89e-01 1.79e-09
Condensation of Prometaphase Chromosomes 11 7.92e-05 6.87e-01 4.57e-04
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 2.31e-04 6.72e-01 1.12e-03
Formation of ATP by chemiosmotic coupling 18 9.15e-07 6.68e-01 7.48e-06
SLBP independent Processing of Histone Pre-mRNAs 10 3.22e-04 6.57e-01 1.50e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.69e-04 6.55e-01 8.75e-04
DNA strand elongation 32 1.49e-10 6.54e-01 1.97e-09
Translesion synthesis by REV1 16 9.42e-06 6.40e-01 6.40e-05
Translesion synthesis by POLK 17 5.71e-06 6.35e-01 4.07e-05
Folding of actin by CCT/TriC 10 5.53e-04 6.31e-01 2.45e-03
SCF(Skp2)-mediated degradation of p27/p21 60 4.00e-17 6.27e-01 2.20e-15
The role of GTSE1 in G2/M progression after G2 checkpoint 58 4.32e-16 6.17e-01 1.90e-14
Metabolism of cofactors 19 3.58e-06 6.14e-01 2.65e-05
Regulation of PTEN mRNA translation 12 2.44e-04 -6.12e-01 1.17e-03
Ubiquitin-dependent degradation of Cyclin D 50 9.50e-14 6.08e-01 2.53e-12
Lagging Strand Synthesis 20 2.88e-06 6.04e-01 2.17e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 7.16e-13 5.98e-01 1.50e-11
Removal of the Flap Intermediate 14 1.18e-04 5.94e-01 6.53e-04
Vpu mediated degradation of CD4 50 3.71e-13 5.94e-01 8.30e-12
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.87e-04 -5.91e-01 2.97e-03
Negative regulation of NOTCH4 signaling 54 6.48e-14 5.89e-01 1.79e-12
Hh mutants are degraded by ERAD 54 9.03e-14 5.86e-01 2.44e-12
SCF-beta-TrCP mediated degradation of Emi1 53 1.66e-13 5.85e-01 4.05e-12
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.10e-13 5.83e-01 4.96e-12
HuR (ELAVL1) binds and stabilizes mRNA 10 1.56e-03 5.78e-01 6.11e-03
Regulation of BACH1 activity 11 9.75e-04 5.74e-01 4.10e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 2.48e-12 5.72e-01 4.45e-11
p53-Independent DNA Damage Response 50 2.48e-12 5.72e-01 4.45e-11
p53-Independent G1/S DNA damage checkpoint 50 2.48e-12 5.72e-01 4.45e-11
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 13 3.63e-04 -5.71e-01 1.68e-03
Signaling by FGFR2 IIIa TM 19 1.82e-05 5.68e-01 1.18e-04
Hedgehog ligand biogenesis 63 7.41e-15 5.66e-01 2.45e-13
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.85e-05 5.66e-01 5.01e-04
Purine salvage 12 6.96e-04 5.65e-01 2.99e-03
GLI3 is processed to GLI3R by the proteasome 57 1.58e-13 5.65e-01 3.99e-12
Vif-mediated degradation of APOBEC3G 52 1.92e-12 5.64e-01 3.71e-11
Formation of tubulin folding intermediates by CCT/TriC 23 2.97e-06 5.63e-01 2.22e-05
Hh mutants abrogate ligand secretion 57 2.06e-13 5.62e-01 4.94e-12
Defective CFTR causes cystic fibrosis 58 1.36e-13 5.61e-01 3.48e-12
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.62e-04 5.61e-01 2.08e-03
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.22e-06 5.60e-01 9.83e-06
PCNA-Dependent Long Patch Base Excision Repair 21 8.81e-06 5.60e-01 6.02e-05
NIK–>noncanonical NF-kB signaling 57 2.86e-13 5.59e-01 6.54e-12
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 1.34e-03 5.59e-01 5.37e-03
MASTL Facilitates Mitotic Progression 10 2.25e-03 5.58e-01 8.40e-03
Orc1 removal from chromatin 69 1.12e-15 5.57e-01 4.64e-14
Regulation of ornithine decarboxylase (ODC) 49 1.51e-11 5.57e-01 2.37e-10
Degradation of GLI2 by the proteasome 57 3.74e-13 5.56e-01 8.30e-12
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 2.63e-12 5.55e-01 4.65e-11
Cross-presentation of soluble exogenous antigens (endosomes) 47 4.83e-11 5.54e-01 6.98e-10
Mitochondrial translation elongation 90 1.01e-19 5.54e-01 7.17e-18
APC/C-mediated degradation of cell cycle proteins 86 9.55e-19 5.51e-01 5.47e-17
Regulation of mitotic cell cycle 86 9.55e-19 5.51e-01 5.47e-17
Mitochondrial translation termination 90 1.80e-19 5.50e-01 1.17e-17
Regulation of Apoptosis 51 1.08e-11 5.50e-01 1.71e-10
Mitochondrial translation initiation 90 2.62e-19 5.47e-01 1.63e-17
Translesion synthesis by POLI 17 9.88e-05 5.45e-01 5.55e-04
CDT1 association with the CDC6:ORC:origin complex 57 1.11e-12 5.44e-01 2.28e-11
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 4.33e-16 5.42e-01 1.90e-14
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.42e-04 5.42e-01 2.00e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 74 8.29e-16 5.41e-01 3.53e-14
Mitochondrial translation 96 6.18e-20 5.39e-01 4.60e-18
Activation of the pre-replicative complex 33 8.29e-08 5.39e-01 7.91e-07
Autodegradation of the E3 ubiquitin ligase COP1 49 6.59e-11 5.39e-01 9.30e-10
Degradation of GLI1 by the proteasome 57 1.97e-12 5.38e-01 3.76e-11
Cristae formation 31 2.17e-07 5.38e-01 1.98e-06
G1/S Transition 131 4.31e-26 5.34e-01 7.12e-24
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 4.26e-06 5.31e-01 3.12e-05
Regulation of APC/C activators between G1/S and early anaphase 79 3.21e-16 5.31e-01 1.59e-14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 6.87e-15 5.30e-01 2.32e-13
Processive synthesis on the lagging strand 15 3.91e-04 5.29e-01 1.79e-03
Recognition of DNA damage by PCNA-containing replication complex 30 5.76e-07 5.27e-01 4.93e-06
Cyclin E associated events during G1/S transition 83 1.04e-16 5.27e-01 5.51e-15
Dectin-1 mediated noncanonical NF-kB signaling 59 2.70e-12 5.26e-01 4.74e-11
Cholesterol biosynthesis 24 8.26e-06 5.26e-01 5.69e-05
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 2.01e-14 5.25e-01 5.99e-13
Mismatch Repair 15 4.69e-04 5.22e-01 2.10e-03
Synthesis of DNA 118 1.40e-22 5.20e-01 1.39e-20
G1/S DNA Damage Checkpoints 64 6.02e-13 5.20e-01 1.30e-11
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.86e-04 5.18e-01 3.32e-03
Translesion Synthesis by POLH 18 1.49e-04 5.16e-01 7.85e-04
p53-Dependent G1 DNA Damage Response 62 2.32e-12 5.15e-01 4.32e-11
p53-Dependent G1/S DNA damage checkpoint 62 2.32e-12 5.15e-01 4.32e-11
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 6.33e-14 5.11e-01 1.78e-12
Cyclin A:Cdk2-associated events at S phase entry 85 4.35e-16 5.10e-01 1.90e-14
Suppression of phagosomal maturation 13 1.54e-03 5.07e-01 6.08e-03
ROS sensing by NFE2L2 55 7.72e-11 5.07e-01 1.05e-09
Polymerase switching on the C-strand of the telomere 26 8.00e-06 5.06e-01 5.62e-05
Diseases associated with glycosylation precursor biosynthesis 18 2.10e-04 5.04e-01 1.04e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.09e-03 5.04e-01 4.53e-03
APC/C:Cdc20 mediated degradation of Securin 66 1.54e-12 5.03e-01 3.06e-11
Stabilization of p53 53 2.52e-10 5.02e-01 3.26e-09
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 3.68e-12 5.02e-01 6.37e-11
Hyaluronan uptake and degradation 10 6.43e-03 4.98e-01 2.10e-02
Polo-like kinase mediated events 16 6.10e-04 4.95e-01 2.67e-03
Glycogen storage diseases 14 1.47e-03 4.91e-01 5.80e-03
Regulation of HMOX1 expression and activity 63 1.74e-11 4.90e-01 2.70e-10
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 2.38e-03 4.87e-01 8.76e-03
Activation of ATR in response to replication stress 37 3.27e-07 4.85e-01 2.92e-06
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.90e-11 4.85e-01 2.92e-10
CDK-mediated phosphorylation and removal of Cdc6 71 1.76e-12 4.84e-01 3.45e-11
S Phase 160 8.65e-26 4.80e-01 1.29e-23
Syndecan interactions 20 2.02e-04 4.80e-01 1.01e-03
Regulation of RUNX3 expression and activity 54 1.07e-09 4.80e-01 1.31e-08
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.90e-03 4.79e-01 7.28e-03
InlB-mediated entry of Listeria monocytogenes into host cell 15 1.35e-03 4.78e-01 5.42e-03
Prefoldin mediated transfer of substrate to CCT/TriC 27 1.80e-05 4.77e-01 1.18e-04
Regulation of localization of FOXO transcription factors 12 4.50e-03 4.74e-01 1.53e-02
G0 and Early G1 27 2.23e-05 4.71e-01 1.43e-04
Signaling by NOTCH4 82 1.66e-13 4.71e-01 4.05e-12
Switching of origins to a post-replicative state 89 1.58e-14 4.71e-01 4.89e-13
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 8.20e-06 4.70e-01 5.69e-05
Advanced glycosylation endproduct receptor signaling 11 6.92e-03 4.70e-01 2.21e-02
Processing and activation of SUMO 10 1.01e-02 4.70e-01 3.02e-02
Activation of NF-kappaB in B cells 65 7.51e-11 4.67e-01 1.04e-09
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 1.30e-03 4.64e-01 5.29e-03
Degradation of DVL 55 2.83e-09 4.63e-01 3.34e-08
Synthesis, secretion, and deacylation of Ghrelin 13 3.89e-03 4.62e-01 1.33e-02
Transcription of E2F targets under negative control by DREAM complex 19 4.94e-04 4.62e-01 2.19e-03
Mitotic G1 phase and G1/S transition 147 7.60e-22 4.58e-01 7.07e-20
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.87e-06 4.57e-01 2.17e-05
Metabolism of polyamines 57 3.46e-09 4.52e-01 4.02e-08
Extension of Telomeres 51 2.45e-08 4.51e-01 2.55e-07
Degradation of AXIN 53 1.40e-08 4.50e-01 1.51e-07
Separation of Sister Chromatids 168 8.33e-24 4.49e-01 9.54e-22
HSF1 activation 26 7.49e-05 4.49e-01 4.39e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.40e-03 4.48e-01 5.56e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.40e-03 4.48e-01 5.56e-03
Regulation of mRNA stability by proteins that bind AU-rich elements 87 6.76e-13 4.45e-01 1.44e-11
Telomere Extension By Telomerase 23 2.27e-04 4.44e-01 1.10e-03
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.15e-03 4.43e-01 4.69e-03
DNA Replication Pre-Initiation 108 1.90e-15 4.42e-01 7.45e-14
Cellular response to hypoxia 73 6.65e-11 4.42e-01 9.30e-10
Butyrophilin (BTN) family interactions 11 1.12e-02 -4.41e-01 3.34e-02
Caspase activation via Dependence Receptors in the absence of ligand 10 1.63e-02 -4.39e-01 4.51e-02
DNA Replication 151 2.10e-20 4.36e-01 1.74e-18
Downstream signaling events of B Cell Receptor (BCR) 79 2.89e-11 4.33e-01 4.31e-10
NRIF signals cell death from the nucleus 16 2.92e-03 4.30e-01 1.05e-02
Resolution of Sister Chromatid Cohesion 105 2.98e-14 4.29e-01 8.70e-13
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 1.55e-05 4.28e-01 1.02e-04
PINK1-PRKN Mediated Mitophagy 21 7.38e-04 4.25e-01 3.14e-03
Chaperone Mediated Autophagy 18 1.79e-03 4.25e-01 6.87e-03
Mitotic Metaphase and Anaphase 229 1.15e-28 4.25e-01 3.41e-26
Glutamate and glutamine metabolism 13 8.01e-03 4.25e-01 2.50e-02
Mitotic Anaphase 228 2.46e-28 4.23e-01 6.09e-26
Synthesis of very long-chain fatty acyl-CoAs 23 4.44e-04 4.23e-01 2.01e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 2.06e-02 4.23e-01 5.50e-02
Depolymerisation of the Nuclear Lamina 15 4.77e-03 4.21e-01 1.61e-02
Calnexin/calreticulin cycle 26 2.23e-04 4.18e-01 1.09e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 92 4.02e-12 4.18e-01 6.71e-11
Amplification of signal from the kinetochores 92 4.02e-12 4.18e-01 6.71e-11
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 2.19e-03 4.17e-01 8.17e-03
Downstream TCR signaling 90 8.06e-12 4.17e-01 1.32e-10
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 3.10e-04 4.17e-01 1.45e-03
ER-Phagosome pathway 86 2.36e-11 4.16e-01 3.59e-10
Regulation of RAS by GAPs 64 8.31e-09 4.16e-01 9.16e-08
Translation of Replicase and Assembly of the Replication Transcription Complex 13 9.43e-03 4.16e-01 2.87e-02
Antigen processing-Cross presentation 99 1.12e-12 4.13e-01 2.28e-11
Telomere C-strand (Lagging Strand) Synthesis 34 3.41e-05 4.11e-01 2.08e-04
Fatty acyl-CoA biosynthesis 35 2.95e-05 4.08e-01 1.85e-04
Telomere C-strand synthesis initiation 13 1.14e-02 4.05e-01 3.38e-02
FCERI mediated NF-kB activation 76 1.05e-09 4.05e-01 1.30e-08
EML4 and NUDC in mitotic spindle formation 96 8.27e-12 4.03e-01 1.34e-10
Asymmetric localization of PCP proteins 62 3.96e-08 4.03e-01 3.93e-07
Host Interactions of HIV factors 126 6.36e-15 4.02e-01 2.25e-13
Assembly of the pre-replicative complex 91 3.80e-11 4.01e-01 5.54e-10
VLDLR internalisation and degradation 11 2.14e-02 4.00e-01 5.69e-02
Pentose phosphate pathway 13 1.28e-02 3.99e-01 3.70e-02
APC-Cdc20 mediated degradation of Nek2A 26 4.40e-04 3.98e-01 2.00e-03
Nucleotide salvage 22 1.28e-03 3.97e-01 5.22e-03
Establishment of Sister Chromatid Cohesion 11 2.31e-02 3.96e-01 6.00e-02
ABC transporter disorders 74 3.98e-09 3.95e-01 4.49e-08
mRNA Capping 29 2.36e-04 3.94e-01 1.14e-03
Resolution of Abasic Sites (AP sites) 38 2.66e-05 3.94e-01 1.67e-04
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 1.40e-02 3.94e-01 3.97e-02
Defective EXT2 causes exostoses 2 13 1.40e-02 3.94e-01 3.97e-02
Regulation of RUNX2 expression and activity 70 1.27e-08 3.93e-01 1.39e-07
Detoxification of Reactive Oxygen Species 31 1.52e-04 3.93e-01 8.00e-04
ATF6 (ATF6-alpha) activates chaperones 12 1.85e-02 3.93e-01 5.01e-02
Class I peroxisomal membrane protein import 19 3.07e-03 3.92e-01 1.09e-02
Chromosome Maintenance 110 1.36e-12 3.91e-01 2.73e-11
Purine catabolism 16 6.95e-03 3.90e-01 2.21e-02
Cell Cycle Checkpoints 260 2.43e-27 3.89e-01 4.53e-25
Mitochondrial protein import 64 7.16e-08 3.89e-01 6.92e-07
E2F mediated regulation of DNA replication 22 1.66e-03 3.87e-01 6.46e-03
FOXO-mediated transcription of cell cycle genes 17 5.90e-03 3.86e-01 1.95e-02
Mitotic Spindle Checkpoint 109 3.73e-12 3.85e-01 6.37e-11
Metabolism of Angiotensinogen to Angiotensins 12 2.10e-02 3.85e-01 5.58e-02
FGFR1c ligand binding and activation 10 3.57e-02 -3.84e-01 8.67e-02
Crosslinking of collagen fibrils 10 3.62e-02 3.83e-01 8.75e-02
G2/M Checkpoints 140 5.59e-15 3.82e-01 2.08e-13
FGFR2 alternative splicing 25 1.02e-03 3.79e-01 4.29e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 125 2.64e-13 3.78e-01 6.15e-12
Diseases of carbohydrate metabolism 31 2.69e-04 3.78e-01 1.28e-03
Termination of translesion DNA synthesis 32 2.21e-04 3.77e-01 1.09e-03
Cyclin A/B1/B2 associated events during G2/M transition 25 1.14e-03 3.76e-01 4.69e-03
Lewis blood group biosynthesis 16 9.35e-03 -3.75e-01 2.85e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 2.00e-02 3.73e-01 5.39e-02
TP53 Regulates Transcription of Cell Cycle Genes 48 8.01e-06 3.72e-01 5.62e-05
Attenuation phase 23 2.01e-03 3.72e-01 7.60e-03
Collagen chain trimerization 42 3.02e-05 -3.72e-01 1.87e-04
SHC1 events in EGFR signaling 14 1.61e-02 3.71e-01 4.47e-02
Regulation of PTEN stability and activity 67 1.50e-07 3.71e-01 1.39e-06
TRP channels 19 5.20e-03 -3.70e-01 1.74e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 7.87e-05 3.70e-01 4.56e-04
eNOS activation 11 3.41e-02 3.69e-01 8.33e-02
Interconversion of nucleotide di- and triphosphates 29 6.25e-04 3.67e-01 2.73e-03
PD-1 signaling 18 7.26e-03 3.65e-01 2.29e-02
HS-GAG degradation 19 5.85e-03 3.65e-01 1.94e-02
MAPK6/MAPK4 signaling 87 3.96e-09 3.65e-01 4.49e-08
Reduction of cytosolic Ca++ levels 12 2.90e-02 3.64e-01 7.24e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 1.14e-03 3.62e-01 4.69e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.14e-03 3.62e-01 4.69e-03
Interleukin-12 family signaling 51 8.22e-06 3.61e-01 5.69e-05
UCH proteinases 92 2.22e-09 3.61e-01 2.66e-08
HDR through Homologous Recombination (HRR) 66 4.52e-07 3.59e-01 3.91e-06
Interleukin-12 signaling 43 4.78e-05 3.58e-01 2.85e-04
APC/C:Cdc20 mediated degradation of Cyclin B 24 2.39e-03 3.58e-01 8.78e-03
Metabolism of non-coding RNA 53 8.05e-06 3.54e-01 5.62e-05
snRNP Assembly 53 8.05e-06 3.54e-01 5.62e-05
Disorders of Developmental Biology 13 2.73e-02 3.53e-01 6.89e-02
Disorders of Nervous System Development 13 2.73e-02 3.53e-01 6.89e-02
Loss of function of MECP2 in Rett syndrome 13 2.73e-02 3.53e-01 6.89e-02
Pervasive developmental disorders 13 2.73e-02 3.53e-01 6.89e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 2.21e-02 -3.53e-01 5.82e-02
SRP-dependent cotranslational protein targeting to membrane 110 1.53e-10 3.53e-01 2.00e-09
Translation 293 2.08e-25 3.53e-01 2.82e-23
Degradation of beta-catenin by the destruction complex 83 2.82e-08 3.52e-01 2.88e-07
RHO GTPases Activate Formins 119 4.99e-11 3.48e-01 7.13e-10
Dual Incision in GG-NER 41 1.22e-04 3.47e-01 6.76e-04
Post-chaperonin tubulin folding pathway 20 7.29e-03 3.47e-01 2.29e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 11 4.67e-02 3.46e-01 1.08e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.65e-06 3.46e-01 1.30e-05
Dual incision in TC-NER 65 1.38e-06 3.46e-01 1.10e-05
Insulin receptor recycling 24 3.35e-03 3.46e-01 1.17e-02
LDL clearance 17 1.35e-02 3.46e-01 3.86e-02
Cell Cycle, Mitotic 513 4.04e-41 3.45e-01 2.00e-38
Presynaptic phase of homologous DNA pairing and strand exchange 39 1.94e-04 3.45e-01 9.77e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 2.96e-04 3.44e-01 1.39e-03
Abortive elongation of HIV-1 transcript in the absence of Tat 23 4.37e-03 3.43e-01 1.48e-02
Negative regulation of MET activity 21 6.56e-03 3.43e-01 2.12e-02
Dissolution of Fibrin Clot 12 4.02e-02 3.42e-01 9.51e-02
Heme biosynthesis 13 3.30e-02 3.42e-01 8.15e-02
Homologous DNA Pairing and Strand Exchange 42 1.28e-04 3.41e-01 6.96e-04
Aggrephagy 21 6.85e-03 3.41e-01 2.19e-02
Cellular response to chemical stress 150 5.49e-13 3.41e-01 1.20e-11
RUNX1 regulates transcription of genes involved in differentiation of HSCs 89 2.86e-08 3.40e-01 2.89e-07
TNFR2 non-canonical NF-kB pathway 90 2.45e-08 3.40e-01 2.55e-07
Inactivation of APC/C via direct inhibition of the APC/C complex 21 7.01e-03 3.40e-01 2.22e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 7.01e-03 3.40e-01 2.22e-02
Respiratory electron transport 103 2.48e-09 3.40e-01 2.95e-08
PCP/CE pathway 90 2.50e-08 3.40e-01 2.57e-07
Zinc transporters 15 2.38e-02 3.37e-01 6.14e-02
Formation of RNA Pol II elongation complex 57 1.06e-05 3.37e-01 7.04e-05
RNA Polymerase II Transcription Elongation 57 1.06e-05 3.37e-01 7.04e-05
DNA Damage Bypass 47 6.34e-05 3.37e-01 3.74e-04
G2/M Transition 181 6.01e-15 3.36e-01 2.18e-13
Initiation of Nuclear Envelope (NE) Reformation 19 1.15e-02 3.35e-01 3.39e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 6.62e-03 3.34e-01 2.13e-02
Activation of BAD and translocation to mitochondria 15 2.50e-02 3.34e-01 6.40e-02
Regulation of expression of SLITs and ROBOs 166 1.10e-13 3.34e-01 2.86e-12
Mitotic G2-G2/M phases 183 8.19e-15 3.32e-01 2.65e-13
TCR signaling 110 1.69e-09 3.32e-01 2.06e-08
Cell Cycle 638 6.43e-47 3.32e-01 9.56e-44
Glycogen synthesis 15 2.60e-02 3.32e-01 6.63e-02
Cytoprotection by HMOX1 120 3.36e-10 3.32e-01 4.27e-09
Endosomal/Vacuolar pathway 12 4.67e-02 3.32e-01 1.08e-01
Interleukin-1 signaling 96 1.99e-08 3.31e-01 2.10e-07
M Phase 371 4.70e-28 3.31e-01 1.00e-25
The citric acid (TCA) cycle and respiratory electron transport 174 4.80e-14 3.31e-01 1.37e-12
Sealing of the nuclear envelope (NE) by ESCRT-III 29 2.04e-03 3.31e-01 7.71e-03
Mitotic Prometaphase 186 6.87e-15 3.31e-01 2.32e-13
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 4.57e-07 3.30e-01 3.93e-06
ATF6 (ATF6-alpha) activates chaperone genes 10 7.09e-02 3.30e-01 1.53e-01
Triglyceride catabolism 19 1.29e-02 3.29e-01 3.73e-02
Phosphorylation of CD3 and TCR zeta chains 17 1.95e-02 3.27e-01 5.27e-02
Signaling by the B Cell Receptor (BCR) 106 6.14e-09 3.27e-01 6.82e-08
GRB2 events in EGFR signaling 13 4.15e-02 3.26e-01 9.76e-02
Sensory perception of sweet, bitter, and umami (glutamate) taste 22 8.10e-03 -3.26e-01 2.52e-02
Signaling by BMP 23 6.89e-03 -3.25e-01 2.20e-02
HDMs demethylate histones 22 8.27e-03 -3.25e-01 2.56e-02
Hyaluronan metabolism 14 3.52e-02 3.25e-01 8.58e-02
HIV Transcription Initiation 47 1.29e-04 3.23e-01 6.96e-04
RNA Polymerase II HIV Promoter Escape 47 1.29e-04 3.23e-01 6.96e-04
RNA Polymerase II Promoter Escape 47 1.29e-04 3.23e-01 6.96e-04
RNA Polymerase II Transcription Initiation 47 1.29e-04 3.23e-01 6.96e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance 47 1.29e-04 3.23e-01 6.96e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 47 1.29e-04 3.23e-01 6.96e-04
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 4.40e-02 3.23e-01 1.03e-01
Cargo concentration in the ER 31 1.98e-03 3.21e-01 7.55e-03
Response of Mtb to phagocytosis 22 9.24e-03 3.21e-01 2.82e-02
Regulated proteolysis of p75NTR 11 6.64e-02 3.20e-01 1.47e-01
Sodium/Calcium exchangers 11 6.64e-02 3.20e-01 1.47e-01
Phospholipase C-mediated cascade: FGFR1 14 3.93e-02 -3.18e-01 9.33e-02
Deposition of new CENPA-containing nucleosomes at the centromere 45 2.22e-04 3.18e-01 1.09e-03
Nucleosome assembly 45 2.22e-04 3.18e-01 1.09e-03
Infection with Mycobacterium tuberculosis 24 7.09e-03 3.17e-01 2.24e-02
Telomere Maintenance 85 4.16e-07 3.17e-01 3.64e-06
Vitamin B5 (pantothenate) metabolism 17 2.35e-02 3.17e-01 6.10e-02
HS-GAG biosynthesis 28 3.87e-03 3.15e-01 1.33e-02
COPI-dependent Golgi-to-ER retrograde traffic 80 1.09e-06 3.15e-01 8.84e-06
Removal of the Flap Intermediate from the C-strand 17 2.48e-02 3.15e-01 6.35e-02
Pyruvate metabolism 29 3.40e-03 3.14e-01 1.19e-02
Chondroitin sulfate biosynthesis 20 1.50e-02 3.14e-01 4.22e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 6.59e-07 3.14e-01 5.51e-06
ABC-family proteins mediated transport 99 6.84e-08 3.14e-01 6.65e-07
ER Quality Control Compartment (ERQC) 21 1.29e-02 3.13e-01 3.72e-02
Complex I biogenesis 57 4.65e-05 3.12e-01 2.79e-04
Nuclear Envelope (NE) Reassembly 73 4.10e-06 3.12e-01 3.02e-05
MHC class II antigen presentation 99 8.39e-08 3.11e-01 7.95e-07
RHO GTPases Activate NADPH Oxidases 22 1.16e-02 3.11e-01 3.42e-02
Defective B3GAT3 causes JDSSDHD 19 1.90e-02 3.11e-01 5.16e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.26e-03 3.11e-01 5.14e-03
Blood group systems biosynthesis 20 1.67e-02 -3.09e-01 4.60e-02
The role of Nef in HIV-1 replication and disease pathogenesis 25 7.48e-03 3.09e-01 2.34e-02
Receptor-type tyrosine-protein phosphatases 19 2.02e-02 -3.08e-01 5.43e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 18 2.38e-02 3.08e-01 6.14e-02
The activation of arylsulfatases 10 9.20e-02 3.08e-01 1.90e-01
FGFR1 ligand binding and activation 14 4.63e-02 -3.08e-01 1.08e-01
RNA Polymerase II Pre-transcription Events 80 1.97e-06 3.07e-01 1.54e-05
Interleukin-6 family signaling 23 1.07e-02 3.07e-01 3.20e-02
Defective B4GALT7 causes EDS, progeroid type 19 2.05e-02 3.07e-01 5.50e-02
Golgi Associated Vesicle Biogenesis 55 8.26e-05 3.07e-01 4.73e-04
IRAK1 recruits IKK complex 10 9.30e-02 3.07e-01 1.91e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 9.30e-02 3.07e-01 1.91e-01
Heparan sulfate/heparin (HS-GAG) metabolism 50 1.76e-04 3.06e-01 9.02e-04
Ribosomal scanning and start codon recognition 57 6.26e-05 3.06e-01 3.71e-04
Signaling by ROBO receptors 211 1.74e-14 3.06e-01 5.28e-13
Gap junction trafficking 18 2.47e-02 3.06e-01 6.35e-02
Adherens junctions interactions 28 5.15e-03 3.05e-01 1.73e-02
mRNA Splicing - Minor Pathway 52 1.42e-04 3.05e-01 7.50e-04
Formation of the ternary complex, and subsequently, the 43S complex 50 1.91e-04 3.05e-01 9.65e-04
HIV Infection 224 3.42e-15 3.05e-01 1.31e-13
Nucleotide Excision Repair 110 3.32e-08 3.05e-01 3.32e-07
Laminin interactions 23 1.14e-02 3.05e-01 3.38e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 36 1.57e-03 -3.04e-01 6.13e-03
CLEC7A (Dectin-1) signaling 97 2.22e-07 3.04e-01 2.01e-06
STAT3 nuclear events downstream of ALK signaling 10 9.61e-02 3.04e-01 1.96e-01
Translation initiation complex formation 57 7.28e-05 3.04e-01 4.28e-04
Phosphorylation of the APC/C 20 1.91e-02 3.03e-01 5.18e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 2.25e-02 3.02e-01 5.91e-02
RUNX2 regulates osteoblast differentiation 23 1.24e-02 -3.01e-01 3.61e-02
Post-translational protein phosphorylation 86 1.36e-06 3.01e-01 1.08e-05
Cyclin D associated events in G1 45 4.71e-04 3.01e-01 2.10e-03
G1 Phase 45 4.71e-04 3.01e-01 2.10e-03
RHOH GTPase cycle 35 2.08e-03 3.01e-01 7.82e-03
E3 ubiquitin ligases ubiquitinate target proteins 53 1.69e-04 2.99e-01 8.75e-04
Cell-cell junction organization 53 1.70e-04 2.98e-01 8.76e-04
MECP2 regulates neuronal receptors and channels 17 3.33e-02 2.98e-01 8.20e-02
Mitophagy 28 6.48e-03 2.97e-01 2.11e-02
Josephin domain DUBs 10 1.04e-01 2.97e-01 2.08e-01
Mitotic Telophase/Cytokinesis 13 6.40e-02 2.97e-01 1.42e-01
Apoptosis 171 2.54e-11 2.95e-01 3.81e-10
Protein localization 159 1.25e-10 2.95e-01 1.67e-09
Golgi-to-ER retrograde transport 113 6.06e-08 2.95e-01 5.97e-07
Activation of the TFAP2 (AP-2) family of transcription factors 11 9.09e-02 -2.94e-01 1.89e-01
RHOF GTPase cycle 41 1.14e-03 2.94e-01 4.69e-03
Lysosome Vesicle Biogenesis 34 3.08e-03 2.93e-01 1.09e-02
Metabolic disorders of biological oxidation enzymes 30 5.45e-03 2.93e-01 1.81e-02
FGFR2 mutant receptor activation 30 5.48e-03 2.93e-01 1.82e-02
BBSome-mediated cargo-targeting to cilium 21 2.06e-02 2.92e-01 5.50e-02
Formation of the Early Elongation Complex 33 3.73e-03 2.92e-01 1.29e-02
Formation of the HIV-1 Early Elongation Complex 33 3.73e-03 2.92e-01 1.29e-02
Kinesins 41 1.32e-03 2.90e-01 5.33e-03
Signaling by NOTCH3 47 5.91e-04 2.90e-01 2.60e-03
Diseases associated with N-glycosylation of proteins 17 3.88e-02 2.89e-01 9.24e-02
Translocation of ZAP-70 to Immunological synapse 15 5.23e-02 2.89e-01 1.20e-01
Viral Messenger RNA Synthesis 44 9.07e-04 2.89e-01 3.82e-03
Gap junction degradation 10 1.14e-01 2.88e-01 2.24e-01
Smooth Muscle Contraction 33 4.17e-03 2.88e-01 1.42e-02
Signaling by CSF3 (G-CSF) 30 6.58e-03 2.87e-01 2.12e-02
RHO GTPases activate IQGAPs 11 1.00e-01 2.86e-01 2.02e-01
Sensory perception of taste 27 1.02e-02 -2.85e-01 3.07e-02
ADP signalling through P2Y purinoceptor 12 18 3.64e-02 2.85e-01 8.77e-02
RAF-independent MAPK1/3 activation 23 1.83e-02 2.84e-01 4.99e-02
ROS and RNS production in phagocytes 32 5.40e-03 2.84e-01 1.80e-02
DNA Damage Recognition in GG-NER 38 2.51e-03 2.83e-01 9.16e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 3.38e-03 2.82e-01 1.18e-02
trans-Golgi Network Vesicle Budding 71 4.07e-05 2.81e-01 2.47e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 2.08e-04 2.81e-01 1.04e-03
RHO GTPases activate CIT 19 3.38e-02 2.81e-01 8.28e-02
Activated NOTCH1 Transmits Signal to the Nucleus 31 6.79e-03 2.81e-01 2.18e-02
Biotin transport and metabolism 11 1.07e-01 2.80e-01 2.12e-01
Listeria monocytogenes entry into host cells 20 3.01e-02 2.80e-01 7.50e-02
Eicosanoid ligand-binding receptors 12 9.32e-02 -2.80e-01 1.91e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 21 2.67e-02 -2.79e-01 6.80e-02
Diseases associated with glycosaminoglycan metabolism 36 3.76e-03 2.79e-01 1.30e-02
Gluconeogenesis 29 9.53e-03 2.78e-01 2.89e-02
Neutrophil degranulation 424 7.47e-23 2.78e-01 7.94e-21
Formation of TC-NER Pre-Incision Complex 53 4.65e-04 2.78e-01 2.09e-03
Cellular hexose transport 18 4.15e-02 2.78e-01 9.76e-02
Influenza Infection 153 3.59e-09 2.76e-01 4.14e-08
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 3.95e-04 2.76e-01 1.80e-03
Non-integrin membrane-ECM interactions 42 1.96e-03 2.76e-01 7.51e-03
Activation of Matrix Metalloproteinases 27 1.34e-02 -2.75e-01 3.83e-02
Homology Directed Repair 111 5.86e-07 2.74e-01 4.95e-06
Programmed Cell Death 197 3.02e-11 2.74e-01 4.44e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression 13 8.78e-02 -2.73e-01 1.86e-01
Pyroptosis 24 2.08e-02 2.73e-01 5.54e-02
Apoptotic cleavage of cell adhesion proteins 10 1.36e-01 2.72e-01 2.52e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 15 6.89e-02 -2.71e-01 1.50e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 181 2.94e-10 2.71e-01 3.77e-09
Selective autophagy 58 3.60e-04 2.71e-01 1.67e-03
EGFR downregulation 31 9.22e-03 2.70e-01 2.82e-02
NR1H2 and NR1H3-mediated signaling 44 1.99e-03 -2.69e-01 7.59e-03
Gap junction trafficking and regulation 20 3.73e-02 2.69e-01 8.95e-02
Nuclear Envelope Breakdown 53 7.09e-04 2.69e-01 3.04e-03
Intrinsic Pathway for Apoptosis 53 7.20e-04 2.68e-01 3.07e-03
Activation of Ca-permeable Kainate Receptor 10 1.42e-01 -2.68e-01 2.60e-01
Ionotropic activity of kainate receptors 10 1.42e-01 -2.68e-01 2.60e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.66e-03 2.68e-01 9.61e-03
HIV Transcription Elongation 42 2.66e-03 2.68e-01 9.61e-03
Tat-mediated elongation of the HIV-1 transcript 42 2.66e-03 2.68e-01 9.61e-03
Activation of BH3-only proteins 29 1.25e-02 2.68e-01 3.64e-02
Metabolism of nucleotides 91 1.01e-05 2.68e-01 6.79e-05
COPII-mediated vesicle transport 66 1.71e-04 2.67e-01 8.76e-04
Diseases of mitotic cell cycle 38 4.68e-03 2.65e-01 1.58e-02
Apoptotic execution phase 49 1.33e-03 2.65e-01 5.37e-03
RUNX2 regulates bone development 30 1.20e-02 -2.65e-01 3.52e-02
Fc epsilon receptor (FCERI) signaling 128 2.41e-07 2.64e-01 2.17e-06
Regulation of gene expression in beta cells 16 6.75e-02 2.64e-01 1.47e-01
Iron uptake and transport 56 6.41e-04 2.64e-01 2.78e-03
Processing of Capped Intronless Pre-mRNA 28 1.58e-02 2.64e-01 4.40e-02
Cap-dependent Translation Initiation 117 8.51e-07 2.63e-01 7.00e-06
Eukaryotic Translation Initiation 117 8.51e-07 2.63e-01 7.00e-06
A tetrasaccharide linker sequence is required for GAG synthesis 25 2.29e-02 2.63e-01 5.98e-02
Intra-Golgi traffic 43 2.89e-03 2.62e-01 1.04e-02
Transcriptional Regulation by E2F6 34 8.12e-03 2.62e-01 2.52e-02
Metabolism of fat-soluble vitamins 36 6.46e-03 2.62e-01 2.10e-02
RNA polymerase II transcribes snRNA genes 71 1.33e-04 2.62e-01 7.10e-04
Influenza Viral RNA Transcription and Replication 134 1.64e-07 2.62e-01 1.50e-06
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 97 8.32e-06 2.62e-01 5.71e-05
Pausing and recovery of Tat-mediated HIV elongation 30 1.31e-02 2.62e-01 3.77e-02
Tat-mediated HIV elongation arrest and recovery 30 1.31e-02 2.62e-01 3.77e-02
Pexophagy 11 1.34e-01 2.61e-01 2.50e-01
IL-6-type cytokine receptor ligand interactions 16 7.11e-02 2.61e-01 1.53e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 2.32e-06 2.61e-01 1.78e-05
SARS-CoV-1 Infection 50 1.50e-03 2.60e-01 5.90e-03
GPVI-mediated activation cascade 30 1.39e-02 2.59e-01 3.97e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 2.30e-02 2.58e-01 5.98e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 13 1.08e-01 -2.57e-01 2.14e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 105 5.57e-06 2.56e-01 4.00e-05
Formation of HIV elongation complex in the absence of HIV Tat 44 3.45e-03 2.55e-01 1.20e-02
Pregnenolone biosynthesis 12 1.27e-01 2.55e-01 2.40e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.27e-01 2.55e-01 2.40e-01
alpha-linolenic acid (ALA) metabolism 12 1.27e-01 2.55e-01 2.40e-01
C-type lectin receptors (CLRs) 128 6.43e-07 2.55e-01 5.41e-06
Mucopolysaccharidoses 11 1.44e-01 2.54e-01 2.63e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 1.27e-01 2.54e-01 2.41e-01
L13a-mediated translational silencing of Ceruloplasmin expression 109 4.49e-06 2.54e-01 3.28e-05
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 2.79e-02 2.54e-01 6.99e-02
Glycogen breakdown (glycogenolysis) 15 8.89e-02 -2.54e-01 1.87e-01
Transcription of the HIV genome 69 2.70e-04 2.54e-01 1.28e-03
Phase 2 - plateau phase 15 9.13e-02 -2.52e-01 1.89e-01
Digestion and absorption 12 1.31e-01 -2.52e-01 2.47e-01
Regulation of HSF1-mediated heat shock response 78 1.31e-04 2.50e-01 7.03e-04
Processive synthesis on the C-strand of the telomere 19 5.93e-02 2.50e-01 1.34e-01
Macroautophagy 111 5.34e-06 2.50e-01 3.86e-05
Formation of a pool of free 40S subunits 99 1.92e-05 2.48e-01 1.24e-04
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 9.66e-02 2.48e-01 1.96e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 9.66e-02 2.48e-01 1.96e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 9.77e-02 2.47e-01 1.98e-01
MAPK3 (ERK1) activation 10 1.76e-01 2.47e-01 3.06e-01
Chaperonin-mediated protein folding 85 8.46e-05 2.47e-01 4.82e-04
tRNA processing in the nucleus 59 1.10e-03 2.46e-01 4.56e-03
Postmitotic nuclear pore complex (NPC) reformation 27 2.73e-02 2.45e-01 6.89e-02
Signaling by EGFR in Cancer 25 3.42e-02 2.45e-01 8.33e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 16 9.04e-02 2.45e-01 1.89e-01
HIV elongation arrest and recovery 32 1.69e-02 2.44e-01 4.64e-02
Pausing and recovery of HIV elongation 32 1.69e-02 2.44e-01 4.64e-02
COPI-independent Golgi-to-ER retrograde traffic 33 1.53e-02 2.44e-01 4.28e-02
WNT5A-dependent internalization of FZD4 15 1.02e-01 2.44e-01 2.04e-01
Collagen degradation 36 1.14e-02 -2.43e-01 3.38e-02
Apoptotic cleavage of cellular proteins 36 1.14e-02 2.43e-01 3.38e-02
RND1 GTPase cycle 42 6.32e-03 2.43e-01 2.07e-02
Transcriptional regulation by RUNX3 94 4.48e-05 2.43e-01 2.70e-04
Metal ion SLC transporters 24 3.93e-02 2.43e-01 9.33e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 8.33e-02 2.43e-01 1.77e-01
Formation of Incision Complex in GG-NER 43 6.09e-03 2.42e-01 2.01e-02
TNFR1-induced NFkappaB signaling pathway 26 3.30e-02 -2.41e-01 8.15e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 53 2.35e-03 2.41e-01 8.69e-03
Cargo recognition for clathrin-mediated endocytosis 100 3.07e-05 2.41e-01 1.88e-04
Synthesis of IP3 and IP4 in the cytosol 25 3.69e-02 -2.41e-01 8.89e-02
Defective C1GALT1C1 causes TNPS 13 1.33e-01 2.41e-01 2.48e-01
DSCAM interactions 10 1.87e-01 -2.41e-01 3.22e-01
Synthesis of PIPs at the late endosome membrane 11 1.67e-01 -2.41e-01 2.94e-01
Signaling by EGFR 50 3.29e-03 2.40e-01 1.16e-02
Glucagon-type ligand receptors 25 3.77e-02 2.40e-01 9.01e-02
Glycosphingolipid metabolism 40 8.66e-03 2.40e-01 2.66e-02
Transferrin endocytosis and recycling 30 2.30e-02 2.40e-01 5.98e-02
Intraflagellar transport 39 9.66e-03 2.39e-01 2.92e-02
Eukaryotic Translation Termination 91 8.16e-05 2.39e-01 4.69e-04
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 1.71e-01 2.38e-01 2.98e-01
HDR through MMEJ (alt-NHEJ) 10 1.92e-01 2.38e-01 3.27e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 1.71e-01 -2.38e-01 2.98e-01
Negative regulation of MAPK pathway 43 6.82e-03 2.38e-01 2.19e-02
Asparagine N-linked glycosylation 277 8.05e-12 2.38e-01 1.32e-10
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 7.70e-05 2.37e-01 4.49e-04
Transcriptional regulation by RUNX2 116 1.04e-05 2.37e-01 6.97e-05
Synaptic adhesion-like molecules 20 6.69e-02 -2.37e-01 1.47e-01
O-linked glycosylation of mucins 55 2.45e-03 2.36e-01 8.97e-03
FCGR activation 11 1.75e-01 -2.36e-01 3.05e-01
Pyrimidine catabolism 11 1.81e-01 2.33e-01 3.12e-01
mTORC1-mediated signalling 24 4.81e-02 2.33e-01 1.11e-01
Pyrimidine salvage 11 1.81e-01 2.33e-01 3.12e-01
Retrograde neurotrophin signalling 14 1.32e-01 2.32e-01 2.48e-01
Viral mRNA Translation 87 1.84e-04 2.32e-01 9.32e-04
Interleukin-10 signaling 35 1.77e-02 2.32e-01 4.86e-02
Tight junction interactions 23 5.46e-02 2.31e-01 1.25e-01
Signaling by ERBB4 54 3.41e-03 2.30e-01 1.19e-02
RHOG GTPase cycle 74 6.39e-04 2.29e-01 2.78e-03
IRE1alpha activates chaperones 50 5.01e-03 2.29e-01 1.69e-02
DNA Double-Strand Break Repair 140 2.89e-06 2.29e-01 2.17e-05
Diseases of glycosylation 132 5.66e-06 2.29e-01 4.05e-05
Presynaptic depolarization and calcium channel opening 12 1.70e-01 -2.29e-01 2.98e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 1.39e-01 2.28e-01 2.56e-01
Glycosaminoglycan metabolism 111 3.19e-05 2.28e-01 1.95e-04
Selenocysteine synthesis 91 1.67e-04 2.28e-01 8.70e-04
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 12 1.72e-01 2.28e-01 3.00e-01
Binding and Uptake of Ligands by Scavenger Receptors 34 2.16e-02 2.28e-01 5.72e-02
Peroxisomal protein import 60 2.30e-03 2.27e-01 8.55e-03
Diseases of metabolism 220 5.99e-09 2.27e-01 6.70e-08
Peptide chain elongation 87 2.50e-04 2.27e-01 1.20e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 3.03e-05 2.27e-01 1.87e-04
Nonsense-Mediated Decay (NMD) 113 3.03e-05 2.27e-01 1.87e-04
Metabolism of vitamins and cofactors 173 2.58e-07 2.27e-01 2.31e-06
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.17e-01 2.27e-01 2.27e-01
Retinoid metabolism and transport 32 2.66e-02 2.26e-01 6.79e-02
Chondroitin sulfate/dermatan sulfate metabolism 49 6.13e-03 2.26e-01 2.01e-02
WNT ligand biogenesis and trafficking 24 5.53e-02 2.26e-01 1.26e-01
Base Excision Repair 64 1.78e-03 2.26e-01 6.84e-03
Disorders of transmembrane transporters 157 1.03e-06 2.26e-01 8.37e-06
RHO GTPase Effectors 258 4.13e-10 2.26e-01 5.21e-09
RHO GTPases Activate ROCKs 19 8.90e-02 2.25e-01 1.87e-01
Protein folding 91 2.04e-04 2.25e-01 1.02e-03
Hedgehog ‘off’ state 96 1.42e-04 2.25e-01 7.50e-04
Autophagy 125 1.50e-05 2.24e-01 9.85e-05
Regulation of PLK1 Activity at G2/M Transition 87 3.11e-04 2.24e-01 1.45e-03
RAB geranylgeranylation 62 2.33e-03 2.24e-01 8.62e-03
TRAF6 mediated IRF7 activation 17 1.11e-01 -2.23e-01 2.17e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.05e-02 2.23e-01 5.49e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.51e-02 2.22e-01 1.80e-01
GAB1 signalosome 17 1.13e-01 2.22e-01 2.21e-01
Signaling by FGFR2 in disease 40 1.55e-02 2.21e-01 4.33e-02
RORA activates gene expression 18 1.04e-01 -2.21e-01 2.09e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 9.57e-02 2.21e-01 1.96e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 9.57e-02 2.21e-01 1.96e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 2.19e-02 2.21e-01 5.79e-02
Insulin processing 25 5.64e-02 2.20e-01 1.28e-01
SARS-CoV-2 Infection 71 1.36e-03 2.20e-01 5.44e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 8.92e-02 -2.20e-01 1.87e-01
DNA Repair 298 6.69e-11 2.19e-01 9.30e-10
Eukaryotic Translation Elongation 92 2.75e-04 2.19e-01 1.30e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 9.05e-02 2.19e-01 1.89e-01
Neurodegenerative Diseases 20 9.05e-02 2.19e-01 1.89e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 4.20e-07 2.18e-01 3.65e-06
Transport of vitamins, nucleosides, and related molecules 35 2.54e-02 2.18e-01 6.49e-02
Synthesis of PC 28 4.56e-02 2.18e-01 1.06e-01
Retrograde transport at the Trans-Golgi-Network 49 8.43e-03 2.17e-01 2.61e-02
Assembly and cell surface presentation of NMDA receptors 25 6.07e-02 -2.17e-01 1.36e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.22e-01 2.17e-01 2.34e-01
Plasma lipoprotein clearance 30 4.01e-02 2.17e-01 9.50e-02
Rap1 signalling 15 1.47e-01 2.16e-01 2.67e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 1.47e-01 2.16e-01 2.67e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 24 6.70e-02 2.16e-01 1.47e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 24 6.70e-02 2.16e-01 1.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 6.70e-02 2.16e-01 1.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 6.70e-02 2.16e-01 1.47e-01
Diseases of DNA Double-Strand Break Repair 24 6.70e-02 2.16e-01 1.47e-01
ER to Golgi Anterograde Transport 131 2.06e-05 2.15e-01 1.33e-04
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 2.39e-01 2.15e-01 3.86e-01
Incretin synthesis, secretion, and inactivation 19 1.05e-01 2.15e-01 2.09e-01
Interactions of Vpr with host cellular proteins 37 2.39e-02 2.15e-01 6.15e-02
Interleukin-1 family signaling 128 2.75e-05 2.14e-01 1.73e-04
Hedgehog ‘on’ state 84 6.81e-04 2.14e-01 2.95e-03
Regulation of beta-cell development 33 3.33e-02 2.14e-01 8.20e-02
Post-translational modification: synthesis of GPI-anchored proteins 68 2.33e-03 2.13e-01 8.62e-03
rRNA processing in the nucleus and cytosol 190 3.84e-07 2.13e-01 3.38e-06
Nuclear import of Rev protein 34 3.14e-02 2.13e-01 7.76e-02
Killing mechanisms 12 2.01e-01 2.13e-01 3.41e-01
WNT5:FZD7-mediated leishmania damping 12 2.01e-01 2.13e-01 3.41e-01
Interleukin-15 signaling 14 1.68e-01 2.13e-01 2.95e-01
Deactivation of the beta-catenin transactivating complex 41 1.84e-02 2.13e-01 5.01e-02
Apoptotic factor-mediated response 19 1.09e-01 2.13e-01 2.14e-01
Protein ubiquitination 73 1.71e-03 2.12e-01 6.61e-03
SUMOylation of DNA replication proteins 46 1.27e-02 2.12e-01 3.69e-02
DARPP-32 events 23 7.81e-02 2.12e-01 1.67e-01
Resolution of D-Loop Structures 33 3.59e-02 2.11e-01 8.71e-02
Glyoxylate metabolism and glycine degradation 26 6.28e-02 2.11e-01 1.40e-01
Processing of DNA double-strand break ends 72 2.01e-03 2.10e-01 7.60e-03
Metabolism of porphyrins 22 8.80e-02 2.10e-01 1.86e-01
G beta:gamma signalling through PI3Kgamma 23 8.17e-02 2.10e-01 1.74e-01
Signaling by NOTCH2 33 3.71e-02 2.10e-01 8.93e-02
HDR through Single Strand Annealing (SSA) 37 2.75e-02 2.09e-01 6.92e-02
Association of TriC/CCT with target proteins during biosynthesis 37 2.78e-02 2.09e-01 6.96e-02
Inactivation of CSF3 (G-CSF) signaling 25 7.07e-02 2.09e-01 1.53e-01
Peptide hormone metabolism 70 2.57e-03 2.08e-01 9.37e-03
RHO GTPases activate PAKs 21 9.85e-02 2.08e-01 1.99e-01
COPI-mediated anterograde transport 79 1.44e-03 2.07e-01 5.70e-03
Oncogenic MAPK signaling 77 1.69e-03 2.07e-01 6.58e-03
Unfolded Protein Response (UPR) 92 6.08e-04 2.07e-01 2.67e-03
Synthesis of bile acids and bile salts 31 4.65e-02 -2.07e-01 1.08e-01
mRNA Splicing - Major Pathway 179 1.93e-06 2.06e-01 1.52e-05
Platelet degranulation 112 1.64e-04 2.06e-01 8.60e-04
RND3 GTPase cycle 41 2.25e-02 2.06e-01 5.91e-02
Export of Viral Ribonucleoproteins from Nucleus 33 4.07e-02 2.06e-01 9.60e-02
Spry regulation of FGF signaling 16 1.54e-01 2.06e-01 2.76e-01
Factors involved in megakaryocyte development and platelet production 120 9.80e-05 2.06e-01 5.52e-04
Metabolism of RNA 677 5.92e-20 2.05e-01 4.60e-18
Interactions of Rev with host cellular proteins 37 3.06e-02 2.05e-01 7.61e-02
Triglyceride metabolism 29 5.57e-02 2.05e-01 1.27e-01
Diseases of DNA repair 34 3.83e-02 2.05e-01 9.16e-02
Regulation of TP53 Activity through Phosphorylation 91 7.20e-04 2.05e-01 3.07e-03
Fatty acid metabolism 156 1.16e-05 2.03e-01 7.68e-05
Defective GALNT12 causes CRCS1 12 2.24e-01 2.03e-01 3.68e-01
RHOJ GTPase cycle 54 9.97e-03 2.03e-01 3.00e-02
Transport of the SLBP Dependant Mature mRNA 36 3.56e-02 2.02e-01 8.67e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 1.34e-02 2.02e-01 3.84e-02
Methylation 14 1.91e-01 2.02e-01 3.26e-01
Mitotic Prophase 104 3.72e-04 2.02e-01 1.71e-03
XBP1(S) activates chaperone genes 48 1.56e-02 2.02e-01 4.35e-02
Fanconi Anemia Pathway 36 3.62e-02 2.02e-01 8.75e-02
Late Phase of HIV Life Cycle 135 5.19e-05 2.02e-01 3.09e-04
Phenylalanine and tyrosine metabolism 10 2.70e-01 2.02e-01 4.24e-01
mRNA Splicing 187 1.98e-06 2.01e-01 1.54e-05
Response to elevated platelet cytosolic Ca2+ 117 1.66e-04 2.01e-01 8.68e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 5.80e-04 2.00e-01 2.56e-03
PERK regulates gene expression 32 5.02e-02 2.00e-01 1.16e-01
HSF1-dependent transactivation 33 4.77e-02 1.99e-01 1.10e-01
Citric acid cycle (TCA cycle) 22 1.06e-01 1.99e-01 2.11e-01
Other semaphorin interactions 15 1.83e-01 1.98e-01 3.15e-01
Synthesis of IP2, IP, and Ins in the cytosol 14 1.99e-01 -1.98e-01 3.38e-01
Neurotoxicity of clostridium toxins 10 2.78e-01 1.98e-01 4.35e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 75 3.05e-03 1.98e-01 1.09e-02
Neddylation 223 3.83e-07 1.97e-01 3.38e-06
Unblocking of NMDA receptors, glutamate binding and activation 20 1.27e-01 -1.97e-01 2.41e-01
Defective Intrinsic Pathway for Apoptosis 22 1.10e-01 1.97e-01 2.17e-01
Activation of gene expression by SREBF (SREBP) 42 2.75e-02 1.96e-01 6.92e-02
RHO GTPases Activate WASPs and WAVEs 36 4.14e-02 1.96e-01 9.76e-02
Late endosomal microautophagy 30 6.28e-02 1.96e-01 1.40e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.50e-02 1.96e-01 1.26e-01
Activation of SMO 18 1.50e-01 -1.96e-01 2.70e-01
HIV Life Cycle 147 4.10e-05 1.96e-01 2.48e-04
Signaling by NOTCH 196 2.28e-06 1.96e-01 1.77e-05
Initial triggering of complement 15 1.90e-01 -1.96e-01 3.25e-01
Metabolism of amino acids and derivatives 344 4.39e-10 1.95e-01 5.49e-09
RHOD GTPase cycle 53 1.43e-02 1.94e-01 4.06e-02
Nuclear signaling by ERBB4 29 7.02e-02 1.94e-01 1.52e-01
Metabolism of proteins 1758 1.71e-42 1.94e-01 1.27e-39
Cell junction organization 78 3.10e-03 1.94e-01 1.10e-02
TP53 Regulates Metabolic Genes 85 2.07e-03 1.93e-01 7.80e-03
MET activates PTK2 signaling 18 1.56e-01 1.93e-01 2.78e-01
Transcriptional regulation of granulopoiesis 52 1.63e-02 1.92e-01 4.53e-02
Basigin interactions 23 1.11e-01 1.92e-01 2.17e-01
LGI-ADAM interactions 13 2.31e-01 -1.92e-01 3.77e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 6.01e-02 1.92e-01 1.35e-01
Role of LAT2/NTAL/LAB on calcium mobilization 13 2.33e-01 1.91e-01 3.79e-01
ALK mutants bind TKIs 12 2.52e-01 1.91e-01 4.01e-01
Beta-catenin independent WNT signaling 142 8.73e-05 1.91e-01 4.96e-04
Mitochondrial iron-sulfur cluster biogenesis 13 2.35e-01 1.90e-01 3.80e-01
ISG15 antiviral mechanism 72 5.24e-03 1.90e-01 1.75e-02
TP53 Regulates Transcription of DNA Repair Genes 61 1.02e-02 1.90e-01 3.07e-02
Transport of the SLBP independent Mature mRNA 35 5.18e-02 1.90e-01 1.19e-01
Regulation of TLR by endogenous ligand 14 2.18e-01 1.90e-01 3.61e-01
G2/M DNA damage checkpoint 69 6.50e-03 1.89e-01 2.11e-02
SHC1 events in ERBB2 signaling 22 1.25e-01 1.89e-01 2.38e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 6.48e-02 1.89e-01 1.44e-01
Interaction between L1 and Ankyrins 26 9.69e-02 -1.88e-01 1.97e-01
Signaling by Hippo 20 1.46e-01 1.88e-01 2.65e-01
Early Phase of HIV Life Cycle 13 2.42e-01 1.88e-01 3.89e-01
FGFR1 mutant receptor activation 29 8.15e-02 -1.87e-01 1.73e-01
Glucose metabolism 84 3.06e-03 1.87e-01 1.09e-02
Metabolism of carbohydrates 266 1.51e-07 1.87e-01 1.40e-06
Sphingolipid metabolism 83 3.26e-03 1.87e-01 1.15e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.85e-01 1.86e-01 4.44e-01
Lysine catabolism 12 2.65e-01 -1.86e-01 4.19e-01
Miscellaneous transport and binding events 23 1.23e-01 1.86e-01 2.36e-01
CDC6 association with the ORC:origin complex 11 2.86e-01 1.86e-01 4.46e-01
Metalloprotease DUBs 26 1.02e-01 1.85e-01 2.04e-01
Signaling by Leptin 10 3.11e-01 -1.85e-01 4.73e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.05e-02 1.85e-01 1.89e-01
Vitamin D (calciferol) metabolism 10 3.12e-01 1.85e-01 4.74e-01
Rev-mediated nuclear export of HIV RNA 35 5.89e-02 1.84e-01 1.33e-01
Scavenging by Class A Receptors 18 1.77e-01 1.84e-01 3.06e-01
Heme signaling 43 3.72e-02 -1.84e-01 8.93e-02
Apoptosis induced DNA fragmentation 12 2.73e-01 1.83e-01 4.28e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 2.22e-01 1.82e-01 3.65e-01
Signaling by FGFR1 in disease 36 5.92e-02 -1.82e-01 1.33e-01
Cellular response to heat stress 96 2.10e-03 1.82e-01 7.88e-03
Voltage gated Potassium channels 33 7.15e-02 -1.81e-01 1.54e-01
Cellular responses to stimuli 691 3.65e-16 1.81e-01 1.75e-14
rRNA processing 214 4.94e-06 1.81e-01 3.59e-05
Signaling by Hedgehog 133 3.34e-04 1.80e-01 1.55e-03
Signaling by MET 66 1.17e-02 1.79e-01 3.45e-02
Response of EIF2AK1 (HRI) to heme deficiency 15 2.30e-01 -1.79e-01 3.76e-01
ERBB2 Regulates Cell Motility 15 2.31e-01 1.78e-01 3.78e-01
MAP2K and MAPK activation 36 6.48e-02 1.78e-01 1.44e-01
RNA Polymerase I Transcription Termination 30 9.21e-02 1.78e-01 1.90e-01
Transport to the Golgi and subsequent modification 161 9.97e-05 1.78e-01 5.58e-04
G beta:gamma signalling through BTK 16 2.20e-01 1.77e-01 3.63e-01
RA biosynthesis pathway 18 1.93e-01 1.77e-01 3.29e-01
RAS processing 19 1.83e-01 1.77e-01 3.15e-01
Aflatoxin activation and detoxification 14 2.53e-01 1.76e-01 4.03e-01
Platelet calcium homeostasis 25 1.28e-01 1.76e-01 2.41e-01
rRNA modification in the nucleus and cytosol 60 1.85e-02 1.76e-01 5.01e-02
SUMOylation of transcription cofactors 44 4.36e-02 -1.76e-01 1.02e-01
VEGFR2 mediated vascular permeability 26 1.21e-01 1.76e-01 2.33e-01
Cellular response to starvation 150 2.01e-04 1.76e-01 1.01e-03
Glutamate Neurotransmitter Release Cycle 24 1.36e-01 -1.76e-01 2.52e-01
Infectious disease 747 2.70e-16 1.75e-01 1.38e-14
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 26 1.22e-01 1.75e-01 2.34e-01
Regulation of Complement cascade 30 9.98e-02 -1.74e-01 2.01e-01
STING mediated induction of host immune responses 15 2.45e-01 -1.74e-01 3.92e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 1.80e-01 1.73e-01 3.11e-01
Transcriptional Regulation by TP53 356 1.92e-08 1.73e-01 2.04e-07
Cellular responses to stress 681 1.14e-14 1.73e-01 3.62e-13
Generation of second messenger molecules 29 1.07e-01 1.73e-01 2.12e-01
Signaling by FGFR2 67 1.48e-02 1.72e-01 4.17e-02
RAC2 GTPase cycle 86 5.81e-03 1.72e-01 1.93e-02
Bile acid and bile salt metabolism 38 6.65e-02 -1.72e-01 1.47e-01
Metabolism 1909 7.03e-36 1.71e-01 2.62e-33
AURKA Activation by TPX2 72 1.24e-02 1.70e-01 3.62e-02
FOXO-mediated transcription 61 2.17e-02 1.70e-01 5.75e-02
TNFR1-induced proapoptotic signaling 13 2.89e-01 -1.70e-01 4.48e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 2.40e-01 1.69e-01 3.88e-01
Translation of Structural Proteins 29 1.16e-01 1.69e-01 2.26e-01
Acyl chain remodelling of PI 12 3.12e-01 1.69e-01 4.74e-01
Regulation of FZD by ubiquitination 21 1.81e-01 1.69e-01 3.12e-01
Amino acid transport across the plasma membrane 31 1.05e-01 -1.68e-01 2.10e-01
RHOBTB2 GTPase cycle 23 1.65e-01 1.67e-01 2.90e-01
Defective GALNT3 causes HFTC 12 3.16e-01 1.67e-01 4.77e-01
G beta:gamma signalling through CDC42 18 2.19e-01 1.67e-01 3.62e-01
FOXO-mediated transcription of cell death genes 15 2.62e-01 -1.67e-01 4.15e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 2.33e-01 1.67e-01 3.80e-01
Metabolism of folate and pterines 16 2.48e-01 1.67e-01 3.97e-01
Recycling of bile acids and salts 13 2.98e-01 -1.67e-01 4.59e-01
Antiviral mechanism by IFN-stimulated genes 80 9.96e-03 1.67e-01 3.00e-02
The canonical retinoid cycle in rods (twilight vision) 20 1.97e-01 -1.66e-01 3.36e-01
Clathrin-mediated endocytosis 138 7.59e-04 1.66e-01 3.22e-03
NOTCH3 Intracellular Domain Regulates Transcription 23 1.68e-01 1.66e-01 2.96e-01
Phospholipase C-mediated cascade; FGFR3 11 3.43e-01 -1.65e-01 5.11e-01
FLT3 signaling in disease 28 1.31e-01 1.65e-01 2.46e-01
SUMOylation of immune response proteins 11 3.44e-01 -1.65e-01 5.13e-01
Nucleotide catabolism 32 1.07e-01 1.64e-01 2.12e-01
Signaling by PDGFR in disease 20 2.05e-01 1.64e-01 3.45e-01
AKT phosphorylates targets in the cytosol 14 2.89e-01 1.64e-01 4.48e-01
Activated NTRK2 signals through FRS2 and FRS3 11 3.49e-01 1.63e-01 5.17e-01
Signaling by Interleukins 394 2.91e-08 1.62e-01 2.93e-07
Glutathione conjugation 30 1.24e-01 1.62e-01 2.37e-01
CS/DS degradation 14 2.94e-01 1.62e-01 4.55e-01
Selenoamino acid metabolism 115 2.74e-03 1.62e-01 9.87e-03
N-Glycan antennae elongation 14 2.96e-01 -1.61e-01 4.56e-01
NS1 Mediated Effects on Host Pathways 40 7.80e-02 1.61e-01 1.67e-01
Vesicle-mediated transport 614 8.56e-12 1.61e-01 1.37e-10
Gamma carboxylation, hypusine formation and arylsulfatase activation 37 9.08e-02 1.61e-01 1.89e-01
Aquaporin-mediated transport 39 8.30e-02 1.60e-01 1.76e-01
cGMP effects 14 2.99e-01 1.60e-01 4.59e-01
Metabolism of water-soluble vitamins and cofactors 119 2.63e-03 1.60e-01 9.59e-03
Prostacyclin signalling through prostacyclin receptor 17 2.55e-01 1.59e-01 4.05e-01
RNA Polymerase III Chain Elongation 18 2.43e-01 1.59e-01 3.90e-01
Processing of Capped Intron-Containing Pre-mRNA 238 2.36e-05 1.59e-01 1.51e-04
PIWI-interacting RNA (piRNA) biogenesis 26 1.61e-01 1.59e-01 2.86e-01
Innate Immune System 875 1.28e-15 1.59e-01 5.15e-14
Complement cascade 38 9.15e-02 -1.58e-01 1.90e-01
Protein-protein interactions at synapses 79 1.51e-02 -1.58e-01 4.24e-02
Acetylcholine regulates insulin secretion 10 3.88e-01 1.58e-01 5.57e-01
Post-translational protein modification 1280 1.44e-21 1.58e-01 1.26e-19
Regulation of RUNX1 Expression and Activity 18 2.47e-01 -1.57e-01 3.96e-01
Signal transduction by L1 21 2.12e-01 1.57e-01 3.52e-01
Intrinsic Pathway of Fibrin Clot Formation 17 2.62e-01 1.57e-01 4.15e-01
Disease 1474 3.06e-24 1.57e-01 3.79e-22
Membrane Trafficking 582 9.20e-11 1.57e-01 1.24e-09
Constitutive Signaling by Overexpressed ERBB2 11 3.69e-01 1.56e-01 5.42e-01
Transport of bile salts and organic acids, metal ions and amine compounds 62 3.35e-02 1.56e-01 8.22e-02
Downregulation of ERBB2:ERBB3 signaling 13 3.30e-01 1.56e-01 4.95e-01
Keratan sulfate/keratin metabolism 29 1.46e-01 1.56e-01 2.66e-01
Thromboxane signalling through TP receptor 22 2.07e-01 1.55e-01 3.48e-01
Hemostasis 505 2.08e-09 1.55e-01 2.51e-08
Recruitment of NuMA to mitotic centrosomes 80 1.64e-02 1.55e-01 4.53e-02
Vpr-mediated nuclear import of PICs 34 1.19e-01 1.54e-01 2.31e-01
Class I MHC mediated antigen processing & presentation 356 5.85e-07 1.54e-01 4.95e-06
Interleukin-4 and Interleukin-13 signaling 98 8.47e-03 1.54e-01 2.62e-02
Regulation of gene expression by Hypoxia-inducible Factor 11 3.78e-01 1.54e-01 5.47e-01
Interleukin-6 signaling 11 3.78e-01 1.54e-01 5.47e-01
Branched-chain amino acid catabolism 21 2.24e-01 1.53e-01 3.68e-01
Metabolism of steroids 140 1.75e-03 1.53e-01 6.78e-03
Glycolysis 67 3.09e-02 1.52e-01 7.66e-02
EPH-ephrin mediated repulsion of cells 47 7.26e-02 1.51e-01 1.56e-01
Formation of the cornified envelope 34 1.27e-01 -1.51e-01 2.41e-01
Synthesis of substrates in N-glycan biosythesis 60 4.42e-02 1.50e-01 1.03e-01
RIP-mediated NFkB activation via ZBP1 16 2.99e-01 -1.50e-01 4.59e-01
Signaling by high-kinase activity BRAF mutants 32 1.42e-01 1.50e-01 2.60e-01
MAPK1/MAPK3 signaling 264 2.65e-05 1.50e-01 1.67e-04
Metabolism of steroid hormones 31 1.48e-01 1.50e-01 2.68e-01
Platelet homeostasis 76 2.44e-02 1.49e-01 6.28e-02
Transcriptional regulation by RUNX1 190 3.83e-04 1.49e-01 1.76e-03
Vasopressin regulates renal water homeostasis via Aquaporins 36 1.21e-01 1.49e-01 2.34e-01
Signaling by PDGFRA extracellular domain mutants 12 3.72e-01 1.49e-01 5.43e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.72e-01 1.49e-01 5.43e-01
Interleukin-20 family signaling 19 2.62e-01 -1.49e-01 4.15e-01
SARS-CoV Infections 151 1.62e-03 1.49e-01 6.32e-03
Anchoring of the basal body to the plasma membrane 97 1.20e-02 1.48e-01 3.51e-02
Signaling by FGFR3 fusions in cancer 10 4.19e-01 1.47e-01 5.88e-01
G beta:gamma signalling through PLC beta 18 2.80e-01 1.47e-01 4.37e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.32e-01 1.47e-01 3.79e-01
Centrosome maturation 81 2.29e-02 1.46e-01 5.98e-02
Recruitment of mitotic centrosome proteins and complexes 81 2.29e-02 1.46e-01 5.98e-02
Regulated Necrosis 51 7.09e-02 1.46e-01 1.53e-01
IRAK2 mediated activation of TAK1 complex 10 4.24e-01 1.46e-01 5.93e-01
Phase 0 - rapid depolarisation 30 1.67e-01 -1.46e-01 2.94e-01
Cell-Cell communication 109 8.66e-03 1.45e-01 2.66e-02
SUMOylation of DNA damage response and repair proteins 76 2.85e-02 1.45e-01 7.14e-02
SHC1 events in ERBB4 signaling 14 3.47e-01 1.45e-01 5.15e-01
EPH-Ephrin signaling 90 1.83e-02 1.44e-01 4.99e-02
Signaling by Non-Receptor Tyrosine Kinases 54 6.87e-02 1.43e-01 1.50e-01
Signaling by PTK6 54 6.87e-02 1.43e-01 1.50e-01
p130Cas linkage to MAPK signaling for integrins 13 3.72e-01 -1.43e-01 5.43e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 26 2.07e-01 -1.43e-01 3.48e-01
SUMOylation of RNA binding proteins 47 9.05e-02 1.43e-01 1.89e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 2.18e-01 -1.42e-01 3.60e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.64e-01 1.42e-01 2.89e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.64e-01 1.42e-01 2.89e-01
PTEN Regulation 140 3.67e-03 1.42e-01 1.27e-02
IRF3-mediated induction of type I IFN 12 3.94e-01 -1.42e-01 5.63e-01
PKMTs methylate histone lysines 46 9.57e-02 -1.42e-01 1.96e-01
Activation of G protein gated Potassium channels 26 2.10e-01 1.42e-01 3.50e-01
G protein gated Potassium channels 26 2.10e-01 1.42e-01 3.50e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 26 2.10e-01 1.42e-01 3.50e-01
Transcriptional regulation by small RNAs 69 4.23e-02 1.41e-01 9.92e-02
Costimulation by the CD28 family 60 5.82e-02 1.41e-01 1.32e-01
Assembly of collagen fibrils and other multimeric structures 55 6.99e-02 -1.41e-01 1.52e-01
Cilium Assembly 181 1.04e-03 1.41e-01 4.34e-03
Diseases of signal transduction by growth factor receptors and second messengers 414 7.91e-07 1.41e-01 6.57e-06
Platelet Aggregation (Plug Formation) 32 1.69e-01 -1.40e-01 2.96e-01
RAF activation 34 1.56e-01 1.40e-01 2.79e-01
Signaling by FLT3 ITD and TKD mutants 16 3.31e-01 1.40e-01 4.96e-01
Degradation of the extracellular matrix 97 1.69e-02 -1.40e-01 4.65e-02
MAPK family signaling cascades 303 2.64e-05 1.40e-01 1.67e-04
STAT5 activation downstream of FLT3 ITD mutants 10 4.43e-01 1.40e-01 6.08e-01
Signaling by FGFR 81 2.93e-02 1.40e-01 7.30e-02
Platelet activation, signaling and aggregation 231 2.47e-04 1.40e-01 1.19e-03
Cytokine Signaling in Immune system 614 3.04e-09 1.40e-01 3.57e-08
Axon guidance 504 7.47e-08 1.40e-01 7.17e-07
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.90e-01 1.38e-01 3.26e-01
RAF/MAP kinase cascade 258 1.31e-04 1.38e-01 7.03e-04
Cargo trafficking to the periciliary membrane 47 1.02e-01 1.38e-01 2.04e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 3.26e-01 1.38e-01 4.90e-01
Activation of GABAB receptors 38 1.42e-01 1.38e-01 2.60e-01
GABA B receptor activation 38 1.42e-01 1.38e-01 2.60e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 2.18e-01 1.37e-01 3.61e-01
G alpha (z) signalling events 42 1.25e-01 1.37e-01 2.38e-01
Sphingolipid de novo biosynthesis 43 1.21e-01 1.37e-01 2.33e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 57 7.41e-02 -1.37e-01 1.59e-01
Repression of WNT target genes 14 3.76e-01 -1.37e-01 5.46e-01
Trafficking of GluR2-containing AMPA receptors 16 3.45e-01 1.36e-01 5.13e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.22e-01 1.36e-01 2.34e-01
Transcriptional Regulation by VENTX 38 1.46e-01 -1.36e-01 2.66e-01
TCF dependent signaling in response to WNT 188 1.31e-03 1.36e-01 5.29e-03
Loss of Nlp from mitotic centrosomes 69 5.13e-02 1.36e-01 1.18e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 5.13e-02 1.36e-01 1.18e-01
TNF signaling 44 1.20e-01 -1.35e-01 2.32e-01
Ion homeostasis 47 1.08e-01 1.35e-01 2.14e-01
tRNA processing in the mitochondrion 20 2.95e-01 -1.35e-01 4.55e-01
EPHA-mediated growth cone collapse 15 3.66e-01 1.35e-01 5.38e-01
MET receptor recycling 10 4.61e-01 -1.35e-01 6.29e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 2.97e-01 1.35e-01 4.58e-01
TRAF3-dependent IRF activation pathway 14 3.83e-01 -1.35e-01 5.52e-01
Adaptive Immune System 656 3.90e-09 1.34e-01 4.46e-08
Nervous system development 527 1.48e-07 1.33e-01 1.39e-06
ABC transporters in lipid homeostasis 17 3.41e-01 -1.33e-01 5.09e-01
NOTCH4 Intracellular Domain Regulates Transcription 20 3.05e-01 1.32e-01 4.67e-01
GABA receptor activation 50 1.05e-01 1.32e-01 2.10e-01
SUMOylation of ubiquitinylation proteins 39 1.53e-01 1.32e-01 2.74e-01
Signaling by ERBB2 ECD mutants 16 3.60e-01 1.32e-01 5.31e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 2.04e-01 1.32e-01 3.44e-01
Immune System 1671 1.44e-19 1.32e-01 9.73e-18
Deadenylation-dependent mRNA decay 53 9.81e-02 1.31e-01 1.99e-01
Cohesin Loading onto Chromatin 10 4.73e-01 1.31e-01 6.39e-01
Antigen processing: Ubiquitination & Proteasome degradation 293 1.13e-04 1.31e-01 6.32e-04
Signaling by Rho GTPases 629 1.90e-08 1.31e-01 2.04e-07
Extra-nuclear estrogen signaling 70 5.84e-02 1.31e-01 1.32e-01
Phospholipase C-mediated cascade; FGFR2 15 3.81e-01 -1.31e-01 5.50e-01
RNA Polymerase III Transcription Initiation 36 1.76e-01 1.30e-01 3.06e-01
Negative regulation of FLT3 14 3.98e-01 1.30e-01 5.67e-01
Phospholipase C-mediated cascade; FGFR4 12 4.34e-01 -1.30e-01 6.03e-01
Signaling by WNT 282 1.79e-04 1.29e-01 9.12e-04
RND2 GTPase cycle 41 1.52e-01 1.29e-01 2.73e-01
Downstream signaling of activated FGFR1 29 2.31e-01 -1.29e-01 3.78e-01
Norepinephrine Neurotransmitter Release Cycle 17 3.60e-01 -1.28e-01 5.31e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 645 2.49e-08 1.28e-01 2.57e-07
Collagen biosynthesis and modifying enzymes 65 7.38e-02 -1.28e-01 1.58e-01
Glucagon signaling in metabolic regulation 28 2.41e-01 1.28e-01 3.88e-01
Adenylate cyclase inhibitory pathway 12 4.43e-01 1.28e-01 6.08e-01
Inhibition of DNA recombination at telomere 40 1.62e-01 1.28e-01 2.87e-01
Organelle biogenesis and maintenance 272 2.82e-04 1.28e-01 1.33e-03
Meiotic recombination 47 1.30e-01 1.28e-01 2.45e-01
RHOBTB GTPase Cycle 35 1.92e-01 1.27e-01 3.27e-01
Amino acids regulate mTORC1 51 1.15e-01 1.27e-01 2.25e-01
Constitutive Signaling by EGFRvIII 15 3.93e-01 1.27e-01 5.61e-01
Signaling by EGFRvIII in Cancer 15 3.93e-01 1.27e-01 5.61e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.44e-01 1.27e-01 3.91e-01
Arachidonic acid metabolism 44 1.47e-01 1.26e-01 2.66e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 4.49e-01 1.26e-01 6.16e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 3.99e-01 1.26e-01 5.67e-01
Uptake and function of anthrax toxins 11 4.73e-01 -1.25e-01 6.39e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.63e-01 1.24e-01 2.89e-01
SUMOylation of SUMOylation proteins 35 2.06e-01 1.24e-01 3.46e-01
HDACs deacetylate histones 54 1.17e-01 -1.23e-01 2.27e-01
Plasma lipoprotein assembly 13 4.41e-01 1.23e-01 6.08e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 3.52e-01 -1.23e-01 5.21e-01
Dopamine Neurotransmitter Release Cycle 23 3.08e-01 -1.23e-01 4.70e-01
RHOQ GTPase cycle 58 1.06e-01 1.23e-01 2.11e-01
Diseases of programmed cell death 62 9.64e-02 1.22e-01 1.96e-01
Phase II - Conjugation of compounds 79 6.11e-02 1.22e-01 1.36e-01
Interleukin-7 signaling 23 3.13e-01 1.22e-01 4.74e-01
Inositol phosphate metabolism 46 1.54e-01 -1.22e-01 2.75e-01
Metabolism of lipids 668 8.44e-08 1.21e-01 7.95e-07
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 36 2.09e-01 1.21e-01 3.50e-01
Erythropoietin activates RAS 14 4.34e-01 1.21e-01 6.03e-01
tRNA processing 124 2.03e-02 1.21e-01 5.44e-02
G-protein activation 20 3.52e-01 1.20e-01 5.21e-01
Antimicrobial peptides 26 2.89e-01 1.20e-01 4.48e-01
MyD88 deficiency (TLR2/4) 14 4.38e-01 1.20e-01 6.05e-01
Phase 4 - resting membrane potential 16 4.09e-01 -1.19e-01 5.79e-01
ESR-mediated signaling 177 6.36e-03 1.19e-01 2.08e-02
PI-3K cascade:FGFR1 19 3.71e-01 -1.18e-01 5.43e-01
Neurexins and neuroligins 50 1.48e-01 -1.18e-01 2.68e-01
NRAGE signals death through JNK 59 1.17e-01 -1.18e-01 2.27e-01
Amine ligand-binding receptors 23 3.29e-01 1.18e-01 4.93e-01
Uptake and actions of bacterial toxins 29 2.74e-01 1.17e-01 4.29e-01
ADORA2B mediated anti-inflammatory cytokines production 86 6.06e-02 1.17e-01 1.36e-01
PPARA activates gene expression 111 3.35e-02 1.17e-01 8.22e-02
Interleukin-27 signaling 10 5.25e-01 1.16e-01 6.90e-01
Defective pyroptosis 35 2.35e-01 1.16e-01 3.80e-01
G-protein beta:gamma signalling 30 2.72e-01 1.16e-01 4.27e-01
Transcriptional activation of mitochondrial biogenesis 53 1.48e-01 -1.15e-01 2.67e-01
RHO GTPases activate PKNs 53 1.48e-01 1.15e-01 2.68e-01
Acetylcholine Neurotransmitter Release Cycle 16 4.28e-01 -1.14e-01 5.98e-01
Regulation of IFNG signaling 13 4.76e-01 1.14e-01 6.41e-01
Interferon Signaling 178 8.83e-03 1.14e-01 2.71e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 58 1.34e-01 1.14e-01 2.50e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 58 1.34e-01 1.14e-01 2.50e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 58 1.34e-01 1.14e-01 2.50e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 58 1.34e-01 1.14e-01 2.50e-01
Signaling by NOTCH1 in Cancer 58 1.34e-01 1.14e-01 2.50e-01
Regulation of TP53 Activity 155 1.46e-02 1.14e-01 4.12e-02
NCAM signaling for neurite out-growth 56 1.42e-01 -1.13e-01 2.60e-01
Developmental Biology 870 1.40e-08 1.13e-01 1.51e-07
Recycling pathway of L1 27 3.10e-01 1.13e-01 4.73e-01
Plasma lipoprotein assembly, remodeling, and clearance 58 1.38e-01 1.13e-01 2.54e-01
Signaling by NODAL 19 3.95e-01 -1.13e-01 5.64e-01
FCGR3A-mediated IL10 synthesis 35 2.49e-01 -1.13e-01 3.97e-01
Regulation of lipid metabolism by PPARalpha 113 3.90e-02 1.12e-01 9.29e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 16 4.37e-01 -1.12e-01 6.04e-01
Diseases associated with the TLR signaling cascade 27 3.15e-01 -1.12e-01 4.76e-01
Diseases of Immune System 27 3.15e-01 -1.12e-01 4.76e-01
Carboxyterminal post-translational modifications of tubulin 37 2.40e-01 1.12e-01 3.87e-01
Reactions specific to the complex N-glycan synthesis pathway 10 5.42e-01 -1.11e-01 7.02e-01
Ub-specific processing proteases 178 1.04e-02 1.11e-01 3.10e-02
Netrin-1 signaling 46 1.92e-01 -1.11e-01 3.28e-01
PKA activation 16 4.43e-01 1.11e-01 6.08e-01
Estrogen-dependent gene expression 110 4.62e-02 1.10e-01 1.08e-01
Sensory processing of sound by inner hair cells of the cochlea 58 1.49e-01 1.10e-01 2.68e-01
SHC-mediated cascade:FGFR4 17 4.35e-01 1.09e-01 6.03e-01
Long-term potentiation 22 3.75e-01 -1.09e-01 5.46e-01
RNA Polymerase I Promoter Opening 25 3.46e-01 -1.09e-01 5.14e-01
Transport of small molecules 620 3.52e-06 1.09e-01 2.62e-05
Signaling by ERBB2 TMD/JMD mutants 22 3.80e-01 1.08e-01 5.50e-01
Synthesis of PA 32 2.94e-01 -1.07e-01 4.55e-01
DAP12 interactions 33 2.87e-01 1.07e-01 4.46e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 3.35e-01 1.07e-01 5.01e-01
RAC3 GTPase cycle 91 7.81e-02 1.07e-01 1.67e-01
Signaling by BRAF and RAF1 fusions 60 1.52e-01 1.07e-01 2.73e-01
PIP3 activates AKT signaling 257 3.21e-03 1.07e-01 1.13e-02
Signal amplification 29 3.23e-01 1.06e-01 4.87e-01
Serotonin Neurotransmitter Release Cycle 18 4.37e-01 -1.06e-01 6.04e-01
Deubiquitination 250 3.94e-03 1.06e-01 1.35e-02
Diseases associated with visual transduction 10 5.64e-01 -1.05e-01 7.17e-01
Diseases of the neuronal system 10 5.64e-01 -1.05e-01 7.17e-01
Retinoid cycle disease events 10 5.64e-01 -1.05e-01 7.17e-01
Defects in cobalamin (B12) metabolism 13 5.11e-01 -1.05e-01 6.76e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 24 3.75e-01 1.05e-01 5.46e-01
MET promotes cell motility 29 3.31e-01 1.04e-01 4.96e-01
RAB GEFs exchange GTP for GDP on RABs 88 9.10e-02 1.04e-01 1.89e-01
Signaling by NOTCH1 74 1.22e-01 1.04e-01 2.34e-01
Platelet sensitization by LDL 16 4.72e-01 1.04e-01 6.39e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 15 4.87e-01 -1.04e-01 6.53e-01
Chromatin modifying enzymes 226 7.47e-03 -1.03e-01 2.34e-02
Chromatin organization 226 7.47e-03 -1.03e-01 2.34e-02
TBC/RABGAPs 43 2.43e-01 -1.03e-01 3.90e-01
PKA activation in glucagon signalling 15 4.92e-01 1.02e-01 6.58e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.94e-01 1.02e-01 6.59e-01
VEGFA-VEGFR2 Pathway 91 9.25e-02 1.02e-01 1.91e-01
ZBP1(DAI) mediated induction of type I IFNs 19 4.42e-01 -1.02e-01 6.08e-01
Senescence-Associated Secretory Phenotype (SASP) 72 1.35e-01 1.02e-01 2.51e-01
Elastic fibre formation 37 2.86e-01 1.01e-01 4.45e-01
Signaling by TGF-beta Receptor Complex 74 1.32e-01 1.01e-01 2.47e-01
Condensation of Prophase Chromosomes 35 3.00e-01 1.01e-01 4.59e-01
TGF-beta receptor signaling activates SMADs 32 3.22e-01 1.01e-01 4.85e-01
SHC-mediated cascade:FGFR3 16 4.87e-01 1.00e-01 6.53e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 2.68e-01 9.99e-02 4.22e-01
Signaling by RAS mutants 41 2.68e-01 9.99e-02 4.22e-01
Signaling by moderate kinase activity BRAF mutants 41 2.68e-01 9.99e-02 4.22e-01
Signaling downstream of RAS mutants 41 2.68e-01 9.99e-02 4.22e-01
Sensory processing of sound 63 1.70e-01 9.99e-02 2.98e-01
N-glycan antennae elongation in the medial/trans-Golgi 25 3.88e-01 -9.96e-02 5.57e-01
Mitochondrial biogenesis 91 1.01e-01 9.93e-02 2.04e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 5.69e-01 9.93e-02 7.22e-01
Nucleotide-like (purinergic) receptors 11 5.70e-01 -9.90e-02 7.23e-01
Integration of energy metabolism 97 9.25e-02 9.88e-02 1.91e-01
Regulation of KIT signaling 15 5.08e-01 -9.88e-02 6.73e-01
FRS-mediated FGFR1 signaling 21 4.34e-01 -9.87e-02 6.03e-01
Protein methylation 15 5.09e-01 -9.86e-02 6.73e-01
AKT phosphorylates targets in the nucleus 10 5.90e-01 9.84e-02 7.40e-01
Amyloid fiber formation 60 1.88e-01 9.82e-02 3.23e-01
Signaling by Receptor Tyrosine Kinases 482 2.25e-04 9.79e-02 1.10e-03
Presynaptic function of Kainate receptors 19 4.62e-01 9.75e-02 6.29e-01
Budding and maturation of HIV virion 28 3.73e-01 9.73e-02 5.44e-01
Common Pathway of Fibrin Clot Formation 15 5.15e-01 9.71e-02 6.78e-01
Processing of Intronless Pre-mRNAs 19 4.64e-01 9.70e-02 6.31e-01
Meiosis 77 1.44e-01 9.64e-02 2.63e-01
Signaling by ERBB2 50 2.38e-01 9.64e-02 3.86e-01
Negative regulation of FGFR4 signaling 28 3.78e-01 9.63e-02 5.47e-01
Nicotinate metabolism 29 3.73e-01 9.55e-02 5.44e-01
O-glycosylation of TSR domain-containing proteins 37 3.15e-01 -9.55e-02 4.76e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 6.01e-01 -9.54e-02 7.48e-01
Lysosphingolipid and LPA receptors 12 5.68e-01 -9.52e-02 7.21e-01
Sema3A PAK dependent Axon repulsion 16 5.10e-01 9.52e-02 6.74e-01
Signaling by Insulin receptor 73 1.61e-01 9.49e-02 2.85e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 3.62e-01 9.46e-02 5.33e-01
Signaling by Activin 15 5.26e-01 -9.45e-02 6.91e-01
Thrombin signalling through proteinase activated receptors (PARs) 30 3.70e-01 9.45e-02 5.43e-01
Regulation of TNFR1 signaling 35 3.36e-01 -9.40e-02 5.01e-01
Signaling by FGFR in disease 60 2.13e-01 9.29e-02 3.54e-01
RHO GTPases activate KTN1 11 5.95e-01 9.25e-02 7.43e-01
Cytosolic tRNA aminoacylation 24 4.33e-01 -9.24e-02 6.03e-01
RNA Polymerase II Transcription Termination 65 1.99e-01 9.22e-02 3.37e-01
RHOA GTPase cycle 146 5.52e-02 9.19e-02 1.26e-01
Signaling by Nuclear Receptors 245 1.35e-02 9.16e-02 3.85e-02
Mitochondrial tRNA aminoacylation 21 4.68e-01 9.15e-02 6.34e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 5.41e-01 9.12e-02 7.01e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 5.41e-01 9.12e-02 7.01e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 5.41e-01 9.12e-02 7.01e-01
Signaling by CTNNB1 phospho-site mutants 15 5.41e-01 9.12e-02 7.01e-01
Signaling by GSK3beta mutants 15 5.41e-01 9.12e-02 7.01e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 5.41e-01 9.12e-02 7.01e-01
Negative regulation of FGFR3 signaling 27 4.15e-01 9.05e-02 5.85e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 5.31e-01 9.04e-02 6.95e-01
DAP12 signaling 26 4.27e-01 9.00e-02 5.96e-01
Cell surface interactions at the vascular wall 105 1.11e-01 8.99e-02 2.18e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 4.11e-01 8.97e-02 5.81e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 13 5.76e-01 -8.97e-02 7.27e-01
Signaling by VEGF 100 1.22e-01 8.94e-02 2.34e-01
NoRC negatively regulates rRNA expression 68 2.03e-01 8.92e-02 3.44e-01
Signaling by Retinoic Acid 38 3.41e-01 8.92e-02 5.09e-01
SUMOylation of intracellular receptors 28 4.14e-01 8.91e-02 5.85e-01
HCMV Infection 106 1.15e-01 8.86e-02 2.25e-01
Peroxisomal lipid metabolism 28 4.18e-01 8.85e-02 5.87e-01
ERK/MAPK targets 22 4.73e-01 -8.83e-02 6.39e-01
PI Metabolism 78 1.80e-01 -8.79e-02 3.11e-01
FCERI mediated MAPK activation 29 4.14e-01 8.76e-02 5.84e-01
Intracellular signaling by second messengers 294 9.64e-03 8.76e-02 2.92e-02
Regulation of signaling by CBL 18 5.20e-01 -8.76e-02 6.84e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 6.01e-01 8.72e-02 7.48e-01
Regulation of TP53 Activity through Acetylation 29 4.16e-01 -8.72e-02 5.86e-01
Signaling by FGFR4 in disease 11 6.20e-01 8.63e-02 7.63e-01
Negative epigenetic regulation of rRNA expression 71 2.09e-01 8.62e-02 3.50e-01
MET activates RAS signaling 11 6.21e-01 8.61e-02 7.63e-01
Cytosolic iron-sulfur cluster assembly 13 5.93e-01 8.55e-02 7.42e-01
GRB2 events in ERBB2 signaling 16 5.54e-01 8.55e-02 7.11e-01
Circadian Clock 67 2.27e-01 -8.54e-02 3.72e-01
Surfactant metabolism 21 4.99e-01 -8.53e-02 6.64e-01
Cell-extracellular matrix interactions 16 5.56e-01 -8.50e-02 7.12e-01
PKA-mediated phosphorylation of CREB 18 5.35e-01 8.45e-02 6.98e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 95 1.54e-01 -8.45e-02 2.76e-01
O-linked glycosylation 102 1.41e-01 8.44e-02 2.59e-01
Regulation of actin dynamics for phagocytic cup formation 60 2.59e-01 8.43e-02 4.11e-01
IKK complex recruitment mediated by RIP1 22 4.96e-01 8.38e-02 6.62e-01
FGFRL1 modulation of FGFR1 signaling 12 6.16e-01 8.35e-02 7.61e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 4.37e-01 8.34e-02 6.04e-01
Trafficking of AMPA receptors 29 4.37e-01 8.34e-02 6.04e-01
SUMOylation 171 5.97e-02 8.34e-02 1.34e-01
Inwardly rectifying K+ channels 32 4.18e-01 8.27e-02 5.87e-01
Activation of RAC1 13 6.06e-01 8.26e-02 7.53e-01
Diseases associated with O-glycosylation of proteins 62 2.61e-01 8.26e-02 4.13e-01
RHOU GTPase cycle 40 3.68e-01 8.22e-02 5.41e-01
FGFR3 mutant receptor activation 10 6.55e-01 -8.17e-02 7.89e-01
Signaling by activated point mutants of FGFR3 10 6.55e-01 -8.17e-02 7.89e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 27 4.63e-01 -8.15e-02 6.31e-01
Signaling by ERBB2 KD Mutants 25 4.89e-01 8.00e-02 6.55e-01
RHO GTPase cycle 436 4.27e-03 7.97e-02 1.45e-02
RNA Polymerase I Promoter Escape 53 3.17e-01 7.95e-02 4.78e-01
Chemokine receptors bind chemokines 29 4.59e-01 7.95e-02 6.26e-01
MicroRNA (miRNA) biogenesis 24 5.01e-01 7.93e-02 6.66e-01
Signaling by RAF1 mutants 37 4.10e-01 7.83e-02 5.79e-01
Interleukin-37 signaling 21 5.36e-01 -7.81e-02 6.99e-01
Regulation of TP53 Activity through Association with Co-factors 12 6.42e-01 7.76e-02 7.77e-01
Ca2+ pathway 60 3.03e-01 -7.69e-02 4.64e-01
Ephrin signaling 19 5.63e-01 -7.67e-02 7.17e-01
rRNA processing in the mitochondrion 24 5.16e-01 -7.66e-02 6.79e-01
Downstream signal transduction 29 4.76e-01 -7.65e-02 6.41e-01
Beta-catenin phosphorylation cascade 17 5.86e-01 7.62e-02 7.36e-01
Nicotinamide salvaging 18 5.77e-01 7.60e-02 7.28e-01
Reproduction 94 2.05e-01 7.56e-02 3.45e-01
Regulation of insulin secretion 69 2.79e-01 7.53e-02 4.37e-01
PLC beta mediated events 46 3.77e-01 -7.52e-02 5.47e-01
Defective B3GALTL causes PpS 36 4.35e-01 -7.52e-02 6.03e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 95 2.10e-01 7.45e-02 3.50e-01
Toll Like Receptor 2 (TLR2) Cascade 95 2.10e-01 7.45e-02 3.50e-01
Toll Like Receptor TLR1:TLR2 Cascade 95 2.10e-01 7.45e-02 3.50e-01
Toll Like Receptor TLR6:TLR2 Cascade 95 2.10e-01 7.45e-02 3.50e-01
Negative regulation of FGFR2 signaling 31 4.74e-01 7.42e-02 6.40e-01
IRAK4 deficiency (TLR2/4) 15 6.19e-01 7.42e-02 7.63e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 6.21e-01 7.37e-02 7.63e-01
SLC transporter disorders 83 2.49e-01 7.32e-02 3.97e-01
SHC-mediated cascade:FGFR2 20 5.72e-01 7.31e-02 7.24e-01
FLT3 Signaling 36 4.49e-01 7.29e-02 6.16e-01
SLC-mediated transmembrane transport 205 7.54e-02 7.20e-02 1.61e-01
Downregulation of ERBB2 signaling 29 5.05e-01 7.16e-02 6.69e-01
HATs acetylate histones 101 2.17e-01 -7.10e-02 3.60e-01
Constitutive Signaling by Aberrant PI3K in Cancer 68 3.13e-01 7.08e-02 4.74e-01
Synthesis of PE 13 6.59e-01 -7.06e-02 7.92e-01
Oncogene Induced Senescence 31 4.97e-01 -7.05e-02 6.62e-01
SUMOylation of transcription factors 19 5.95e-01 7.04e-02 7.43e-01
Nonhomologous End-Joining (NHEJ) 43 4.25e-01 -7.03e-02 5.94e-01
Nitric oxide stimulates guanylate cyclase 18 6.08e-01 6.99e-02 7.53e-01
Effects of PIP2 hydrolysis 24 5.55e-01 -6.97e-02 7.11e-01
The NLRP3 inflammasome 15 6.42e-01 6.94e-02 7.77e-01
Signal Transduction 2215 6.18e-08 6.93e-02 6.05e-07
tRNA modification in the nucleus and cytosol 43 4.33e-01 6.90e-02 6.03e-01
Signaling by PDGF 53 3.86e-01 -6.88e-02 5.54e-01
Activated point mutants of FGFR2 14 6.57e-01 -6.86e-02 7.90e-01
Formation of apoptosome 11 6.94e-01 6.84e-02 8.23e-01
Regulation of the apoptosome activity 11 6.94e-01 6.84e-02 8.23e-01
Downregulation of TGF-beta receptor signaling 26 5.48e-01 6.80e-02 7.06e-01
Potential therapeutics for SARS 82 2.88e-01 6.79e-02 4.47e-01
Neurotransmitter receptors and postsynaptic signal transmission 163 1.35e-01 6.78e-02 2.51e-01
Tie2 Signaling 17 6.30e-01 6.75e-02 7.69e-01
Pre-NOTCH Processing in Golgi 18 6.20e-01 6.74e-02 7.63e-01
Acyl chain remodelling of PC 21 5.93e-01 -6.73e-02 7.42e-01
Role of phospholipids in phagocytosis 24 5.72e-01 -6.66e-02 7.24e-01
Post NMDA receptor activation events 58 3.82e-01 6.63e-02 5.51e-01
Signaling by NTRK3 (TRKC) 16 6.46e-01 -6.63e-02 7.82e-01
Aspartate and asparagine metabolism 10 7.17e-01 -6.62e-02 8.37e-01
Nephrin family interactions 21 6.00e-01 6.61e-02 7.47e-01
Nucleotide biosynthesis 12 6.93e-01 6.59e-02 8.23e-01
Transcriptional regulation of testis differentiation 11 7.06e-01 6.56e-02 8.30e-01
Interleukin receptor SHC signaling 22 5.95e-01 6.55e-02 7.43e-01
Molecules associated with elastic fibres 27 5.61e-01 6.47e-02 7.17e-01
NOD1/2 Signaling Pathway 32 5.28e-01 -6.45e-02 6.92e-01
DNA methylation 27 5.63e-01 -6.43e-02 7.17e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 85 3.06e-01 6.42e-02 4.67e-01
SUMO E3 ligases SUMOylate target proteins 165 1.59e-01 6.35e-02 2.83e-01
Growth hormone receptor signaling 20 6.24e-01 -6.34e-02 7.65e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.83e-01 6.33e-02 6.48e-01
RNA Polymerase III Transcription 41 4.83e-01 6.33e-02 6.48e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 6.53e-01 6.31e-02 7.88e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 26 5.78e-01 6.30e-02 7.28e-01
Ovarian tumor domain proteases 38 5.03e-01 -6.28e-02 6.68e-01
Tryptophan catabolism 13 6.96e-01 -6.25e-02 8.24e-01
Endogenous sterols 23 6.10e-01 -6.15e-02 7.55e-01
Cytochrome c-mediated apoptotic response 13 7.02e-01 6.12e-02 8.27e-01
Trafficking and processing of endosomal TLR 11 7.26e-01 6.10e-02 8.45e-01
Class B/2 (Secretin family receptors) 74 3.66e-01 6.08e-02 5.38e-01
Myogenesis 25 5.99e-01 6.07e-02 7.47e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 28 5.78e-01 -6.07e-02 7.28e-01
Stimuli-sensing channels 87 3.28e-01 -6.07e-02 4.93e-01
Carnitine metabolism 11 7.28e-01 -6.06e-02 8.46e-01
Defects in vitamin and cofactor metabolism 21 6.33e-01 6.01e-02 7.73e-01
Other interleukin signaling 23 6.23e-01 -5.93e-02 7.64e-01
Sema4D in semaphorin signaling 24 6.16e-01 5.91e-02 7.61e-01
Regulation of TP53 Expression and Degradation 36 5.44e-01 5.84e-02 7.03e-01
CD28 dependent PI3K/Akt signaling 19 6.61e-01 -5.80e-02 7.94e-01
Leishmania infection 196 1.63e-01 5.77e-02 2.89e-01
CLEC7A (Dectin-1) induces NFAT activation 11 7.41e-01 -5.76e-02 8.52e-01
Collagen formation 87 3.53e-01 -5.76e-02 5.22e-01
MTOR signalling 40 5.29e-01 5.75e-02 6.93e-01
Integrin signaling 25 6.24e-01 -5.67e-02 7.65e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 7.24e-01 5.65e-02 8.44e-01
Signaling by FGFR3 38 5.48e-01 5.63e-02 7.06e-01
Prolonged ERK activation events 14 7.17e-01 5.59e-02 8.37e-01
Packaging Of Telomere Ends 25 6.29e-01 -5.58e-02 7.69e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 38 5.54e-01 -5.55e-02 7.11e-01
Striated Muscle Contraction 27 6.19e-01 -5.53e-02 7.63e-01
Caspase activation via Death Receptors in the presence of ligand 15 7.11e-01 5.53e-02 8.34e-01
Signaling by cytosolic FGFR1 fusion mutants 18 6.86e-01 -5.50e-02 8.18e-01
Signaling by FGFR4 38 5.60e-01 5.47e-02 7.16e-01
Frs2-mediated activation 12 7.44e-01 5.44e-02 8.54e-01
SHC-mediated cascade:FGFR1 19 6.82e-01 -5.44e-02 8.13e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 4.27e-01 5.41e-02 5.96e-01
Transcriptional Regulation by MECP2 57 4.80e-01 5.40e-02 6.46e-01
Biological oxidations 165 2.32e-01 5.38e-02 3.79e-01
Synthesis of PIPs at the early endosome membrane 16 7.10e-01 -5.37e-02 8.33e-01
MyD88 cascade initiated on plasma membrane 81 4.05e-01 5.35e-02 5.74e-01
Toll Like Receptor 10 (TLR10) Cascade 81 4.05e-01 5.35e-02 5.74e-01
Toll Like Receptor 5 (TLR5) Cascade 81 4.05e-01 5.35e-02 5.74e-01
Metabolism of amine-derived hormones 13 7.39e-01 5.33e-02 8.51e-01
G alpha (q) signalling events 163 2.45e-01 -5.27e-02 3.93e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 21 6.77e-01 -5.26e-02 8.09e-01
Signaling by KIT in disease 19 6.92e-01 -5.25e-02 8.23e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 6.92e-01 -5.25e-02 8.23e-01
The phototransduction cascade 27 6.38e-01 5.23e-02 7.77e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 7.35e-01 5.23e-02 8.50e-01
Regulation of TP53 Degradation 35 5.93e-01 5.22e-02 7.42e-01
Activation of the AP-1 family of transcription factors 10 7.75e-01 -5.21e-02 8.72e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 86 4.04e-01 5.21e-02 5.74e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 95 3.81e-01 5.20e-02 5.50e-01
HCMV Early Events 82 4.17e-01 5.18e-02 5.87e-01
Transcriptional regulation of white adipocyte differentiation 82 4.19e-01 5.16e-02 5.88e-01
FGFR4 ligand binding and activation 11 7.68e-01 -5.13e-02 8.67e-01
Semaphorin interactions 60 4.93e-01 5.12e-02 6.59e-01
Ras activation upon Ca2+ influx through NMDA receptor 20 6.97e-01 -5.02e-02 8.24e-01
PI3K/AKT Signaling in Cancer 95 3.99e-01 5.01e-02 5.67e-01
DNA Damage/Telomere Stress Induced Senescence 52 5.33e-01 -4.99e-02 6.97e-01
Glutathione synthesis and recycling 12 7.66e-01 4.97e-02 8.67e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 5.43e-01 -4.92e-02 7.02e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 6.52e-01 4.92e-02 7.88e-01
TICAM1-dependent activation of IRF3/IRF7 12 7.70e-01 4.87e-02 8.68e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 11 7.81e-01 4.83e-02 8.77e-01
Diseases of hemostasis 11 7.81e-01 4.83e-02 8.77e-01
Glycogen metabolism 26 6.71e-01 4.82e-02 8.03e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 6.30e-01 4.78e-02 7.69e-01
FGFR2c ligand binding and activation 10 7.95e-01 -4.75e-02 8.81e-01
RNA Polymerase I Transcription Initiation 47 5.75e-01 4.72e-02 7.27e-01
Prolactin receptor signaling 11 7.86e-01 -4.72e-02 8.79e-01
Anti-inflammatory response favouring Leishmania parasite infection 114 3.85e-01 4.71e-02 5.53e-01
Leishmania parasite growth and survival 114 3.85e-01 4.71e-02 5.53e-01
SUMOylation of chromatin organization proteins 57 5.43e-01 4.65e-02 7.02e-01
Regulation of FOXO transcriptional activity by acetylation 10 7.99e-01 -4.64e-02 8.84e-01
VEGFR2 mediated cell proliferation 19 7.29e-01 4.58e-02 8.46e-01
FGFR3 ligand binding and activation 11 7.93e-01 -4.56e-02 8.80e-01
FGFR3c ligand binding and activation 11 7.93e-01 -4.56e-02 8.80e-01
Deadenylation of mRNA 22 7.13e-01 4.53e-02 8.35e-01
MyD88 dependent cascade initiated on endosome 87 4.68e-01 4.50e-02 6.34e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 87 4.68e-01 4.50e-02 6.34e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 13 7.79e-01 4.49e-02 8.76e-01
Signaling by FLT3 fusion proteins 19 7.36e-01 4.47e-02 8.50e-01
MyD88-independent TLR4 cascade 94 4.54e-01 4.47e-02 6.20e-01
TRIF(TICAM1)-mediated TLR4 signaling 94 4.54e-01 4.47e-02 6.20e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 7.43e-01 4.47e-02 8.53e-01
Assembly of active LPL and LIPC lipase complexes 14 7.72e-01 4.47e-02 8.70e-01
Receptor Mediated Mitophagy 11 7.98e-01 4.45e-02 8.83e-01
Cytochrome P450 - arranged by substrate type 49 5.90e-01 4.45e-02 7.40e-01
Termination of O-glycan biosynthesis 19 7.38e-01 4.43e-02 8.50e-01
Interleukin-17 signaling 68 5.28e-01 4.43e-02 6.92e-01
Dectin-2 family 18 7.48e-01 4.37e-02 8.56e-01
RHOBTB3 ATPase cycle 10 8.11e-01 -4.36e-02 8.91e-01
Formation of the beta-catenin:TCF transactivating complex 53 5.83e-01 -4.36e-02 7.33e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 8.11e-01 4.36e-02 8.91e-01
PI3K events in ERBB2 signaling 16 7.63e-01 4.36e-02 8.65e-01
B-WICH complex positively regulates rRNA expression 53 5.85e-01 4.34e-02 7.35e-01
Adrenaline,noradrenaline inhibits insulin secretion 26 7.02e-01 4.33e-02 8.27e-01
Transport of Mature Transcript to Cytoplasm 81 5.01e-01 4.32e-02 6.66e-01
FRS-mediated FGFR4 signaling 19 7.45e-01 4.31e-02 8.54e-01
Negative regulation of the PI3K/AKT network 102 4.56e-01 4.27e-02 6.23e-01
Nuclear Events (kinase and transcription factor activation) 62 5.62e-01 -4.25e-02 7.17e-01
Signaling by ERBB2 in Cancer 26 7.13e-01 4.17e-02 8.35e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 7.14e-01 4.15e-02 8.35e-01
Oxidative Stress Induced Senescence 83 5.13e-01 -4.15e-02 6.77e-01
FGFR2 ligand binding and activation 15 7.85e-01 -4.08e-02 8.78e-01
Sensory processing of sound by outer hair cells of the cochlea 44 6.40e-01 4.07e-02 7.77e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 45 6.37e-01 4.07e-02 7.76e-01
CASP8 activity is inhibited 10 8.25e-01 4.03e-02 8.99e-01
Dimerization of procaspase-8 10 8.25e-01 4.03e-02 8.99e-01
Regulation by c-FLIP 10 8.25e-01 4.03e-02 8.99e-01
RHOC GTPase cycle 72 5.55e-01 4.02e-02 7.11e-01
ERKs are inactivated 13 8.03e-01 4.00e-02 8.85e-01
Inflammasomes 20 7.59e-01 -3.96e-02 8.64e-01
Transmission across Chemical Synapses 225 3.11e-01 3.92e-02 4.73e-01
NOTCH1 Intracellular Domain Regulates Transcription 48 6.39e-01 3.92e-02 7.77e-01
Opioid Signalling 82 5.40e-01 3.91e-02 7.01e-01
FCERI mediated Ca+2 mobilization 28 7.22e-01 3.89e-02 8.42e-01
Ion transport by P-type ATPases 49 6.39e-01 3.87e-02 7.77e-01
Muscle contraction 166 3.90e-01 3.86e-02 5.59e-01
ERBB2 Activates PTK6 Signaling 13 8.11e-01 -3.82e-02 8.91e-01
Regulation of IFNA signaling 13 8.12e-01 -3.82e-02 8.91e-01
Negative regulators of DDX58/IFIH1 signaling 35 6.96e-01 -3.82e-02 8.24e-01
Synthesis of PIPs at the Golgi membrane 16 7.92e-01 3.81e-02 8.80e-01
Signaling by FGFR3 in disease 20 7.68e-01 -3.80e-02 8.67e-01
Signaling by FGFR3 point mutants in cancer 20 7.68e-01 -3.80e-02 8.67e-01
Toll Like Receptor 4 (TLR4) Cascade 123 4.67e-01 3.80e-02 6.34e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 6.94e-01 3.79e-02 8.23e-01
p75NTR signals via NF-kB 16 7.93e-01 -3.79e-02 8.80e-01
PI-3K cascade:FGFR4 17 7.88e-01 3.76e-02 8.80e-01
ECM proteoglycans 47 6.57e-01 -3.74e-02 7.91e-01
MAP kinase activation 63 6.12e-01 3.69e-02 7.58e-01
Glycerophospholipid biosynthesis 116 4.93e-01 3.68e-02 6.59e-01
Toll Like Receptor 9 (TLR9) Cascade 91 5.45e-01 3.67e-02 7.04e-01
Integrin cell surface interactions 59 6.27e-01 3.66e-02 7.68e-01
Physiological factors 11 8.34e-01 -3.66e-02 8.99e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 7.29e-01 3.65e-02 8.46e-01
Signaling by TGFB family members 98 5.37e-01 3.61e-02 7.00e-01
tRNA Aminoacylation 42 6.90e-01 -3.56e-02 8.22e-01
Processing of SMDT1 15 8.13e-01 3.52e-02 8.91e-01
SUMOylation of DNA methylation proteins 16 8.08e-01 -3.52e-02 8.89e-01
Cytosolic sulfonation of small molecules 22 7.76e-01 3.51e-02 8.72e-01
CD28 co-stimulation 30 7.41e-01 3.49e-02 8.52e-01
PI3K Cascade 41 6.99e-01 -3.48e-02 8.25e-01
G alpha (s) signalling events 97 5.55e-01 3.47e-02 7.11e-01
Negative regulation of FGFR1 signaling 31 7.45e-01 -3.37e-02 8.54e-01
HCMV Late Events 78 6.07e-01 3.37e-02 7.53e-01
RIPK1-mediated regulated necrosis 27 7.63e-01 3.35e-02 8.65e-01
Regulation of necroptotic cell death 27 7.63e-01 3.35e-02 8.65e-01
NCAM1 interactions 36 7.28e-01 -3.34e-02 8.46e-01
RNA Polymerase III Transcription Termination 23 7.82e-01 3.33e-02 8.77e-01
Nuclear events stimulated by ALK signaling in cancer 19 8.03e-01 3.31e-02 8.85e-01
Cytosolic sensors of pathogen-associated DNA 62 6.54e-01 -3.29e-02 7.89e-01
Transcriptional regulation of pluripotent stem cells 31 7.53e-01 3.27e-02 8.58e-01
ADP signalling through P2Y purinoceptor 1 23 7.87e-01 3.25e-02 8.79e-01
Interferon alpha/beta signaling 58 6.69e-01 3.24e-02 8.02e-01
DCC mediated attractive signaling 14 8.34e-01 3.24e-02 8.99e-01
Signaling by WNT in cancer 33 7.48e-01 -3.23e-02 8.56e-01
APC truncation mutants have impaired AXIN binding 14 8.36e-01 3.20e-02 8.99e-01
AXIN missense mutants destabilize the destruction complex 14 8.36e-01 3.20e-02 8.99e-01
Signaling by AMER1 mutants 14 8.36e-01 3.20e-02 8.99e-01
Signaling by APC mutants 14 8.36e-01 3.20e-02 8.99e-01
Signaling by AXIN mutants 14 8.36e-01 3.20e-02 8.99e-01
Truncations of AMER1 destabilize the destruction complex 14 8.36e-01 3.20e-02 8.99e-01
Signaling by Erythropoietin 25 7.83e-01 -3.19e-02 8.77e-01
Toll-like Receptor Cascades 141 5.13e-01 3.19e-02 6.77e-01
Dermatan sulfate biosynthesis 11 8.55e-01 3.17e-02 9.11e-01
RHOBTB1 GTPase cycle 23 7.93e-01 3.16e-02 8.80e-01
Neurotransmitter release cycle 48 7.06e-01 -3.15e-02 8.30e-01
FRS-mediated FGFR3 signaling 18 8.17e-01 3.14e-02 8.94e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 13 8.46e-01 -3.11e-02 9.08e-01
Triglyceride biosynthesis 10 8.67e-01 -3.07e-02 9.19e-01
Signaling by SCF-KIT 41 7.34e-01 -3.06e-02 8.50e-01
Signaling by ALK fusions and activated point mutants 55 6.98e-01 -3.03e-02 8.24e-01
Signaling by ALK in cancer 55 6.98e-01 -3.03e-02 8.24e-01
DAG and IP3 signaling 38 7.50e-01 -2.99e-02 8.56e-01
Na+/Cl- dependent neurotransmitter transporters 12 8.58e-01 -2.99e-02 9.13e-01
p75 NTR receptor-mediated signalling 96 6.13e-01 2.99e-02 7.58e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 7.92e-01 2.98e-02 8.80e-01
Keratan sulfate biosynthesis 24 8.01e-01 2.97e-02 8.85e-01
Interferon gamma signaling 83 6.41e-01 2.96e-02 7.77e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 26 7.96e-01 2.93e-02 8.82e-01
Visual phototransduction 75 6.65e-01 2.89e-02 7.97e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 51 7.26e-01 -2.84e-02 8.45e-01
activated TAK1 mediates p38 MAPK activation 19 8.31e-01 2.83e-02 8.99e-01
Death Receptor Signalling 139 5.72e-01 -2.77e-02 7.24e-01
Signalling to RAS 20 8.34e-01 -2.71e-02 8.99e-01
CTLA4 inhibitory signaling 17 8.48e-01 -2.69e-02 9.08e-01
Sulfur amino acid metabolism 26 8.13e-01 2.69e-02 8.91e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 67 7.06e-01 -2.67e-02 8.30e-01
Heme degradation 11 8.80e-01 -2.63e-02 9.30e-01
RMTs methylate histone arginines 44 7.63e-01 2.63e-02 8.65e-01
Epigenetic regulation of gene expression 110 6.34e-01 2.62e-02 7.74e-01
EPHB-mediated forward signaling 34 7.93e-01 2.60e-02 8.80e-01
TNFs bind their physiological receptors 21 8.37e-01 -2.59e-02 8.99e-01
RET signaling 37 7.86e-01 -2.58e-02 8.79e-01
Synthesis of PIPs at the plasma membrane 50 7.53e-01 -2.57e-02 8.58e-01
SIRT1 negatively regulates rRNA expression 30 8.09e-01 -2.56e-02 8.90e-01
FCGR3A-mediated phagocytosis 58 7.37e-01 2.55e-02 8.50e-01
Leishmania phagocytosis 58 7.37e-01 2.55e-02 8.50e-01
Parasite infection 58 7.37e-01 2.55e-02 8.50e-01
GABA synthesis, release, reuptake and degradation 18 8.53e-01 2.52e-02 9.10e-01
Class A/1 (Rhodopsin-like receptors) 196 5.47e-01 -2.49e-02 7.05e-01
Signaling by NTRK2 (TRKB) 24 8.33e-01 -2.48e-02 8.99e-01
PECAM1 interactions 11 8.87e-01 2.48e-02 9.34e-01
RUNX3 regulates NOTCH signaling 14 8.74e-01 -2.46e-02 9.25e-01
PI-3K cascade:FGFR3 16 8.67e-01 2.42e-02 9.19e-01
Beta-oxidation of very long chain fatty acids 11 8.91e-01 2.38e-02 9.36e-01
NGF-stimulated transcription 40 8.00e-01 -2.31e-02 8.84e-01
Acyl chain remodelling of PE 22 8.54e-01 2.27e-02 9.10e-01
Signaling by NTRK1 (TRKA) 115 6.76e-01 2.26e-02 8.08e-01
Positive epigenetic regulation of rRNA expression 68 7.49e-01 2.25e-02 8.56e-01
Membrane binding and targetting of GAG proteins 14 8.85e-01 2.24e-02 9.33e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 8.85e-01 2.24e-02 9.33e-01
Toll Like Receptor 3 (TLR3) Cascade 90 7.16e-01 2.22e-02 8.36e-01
Regulation of PTEN gene transcription 61 7.66e-01 2.20e-02 8.67e-01
Interleukin-35 Signalling 12 8.96e-01 2.18e-02 9.38e-01
Signaling by ALK 26 8.51e-01 2.13e-02 9.10e-01
Activation of NMDA receptors and postsynaptic events 71 7.60e-01 2.09e-02 8.64e-01
Cleavage of the damaged pyrimidine 34 8.33e-01 2.08e-02 8.99e-01
Depyrimidination 34 8.33e-01 2.08e-02 8.99e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 34 8.33e-01 2.08e-02 8.99e-01
Sema4D induced cell migration and growth-cone collapse 20 8.72e-01 2.08e-02 9.24e-01
Generic Transcription Pathway 1144 2.34e-01 -2.08e-02 3.80e-01
p75NTR recruits signalling complexes 13 8.99e-01 2.04e-02 9.39e-01
Base-Excision Repair, AP Site Formation 36 8.33e-01 2.04e-02 8.99e-01
p38MAPK events 13 9.02e-01 -1.96e-02 9.41e-01
Sialic acid metabolism 30 8.53e-01 -1.95e-02 9.10e-01
Regulation of MECP2 expression and activity 31 8.53e-01 -1.92e-02 9.10e-01
FRS-mediated FGFR2 signaling 22 8.76e-01 1.92e-02 9.27e-01
IRS-mediated signalling 45 8.24e-01 -1.91e-02 8.99e-01
CaMK IV-mediated phosphorylation of CREB 10 9.18e-01 1.87e-02 9.51e-01
RHOB GTPase cycle 69 7.89e-01 1.86e-02 8.80e-01
Fertilization 17 8.94e-01 -1.86e-02 9.38e-01
Interleukin-2 family signaling 36 8.48e-01 -1.85e-02 9.08e-01
Interleukin-2 signaling 10 9.20e-01 -1.84e-02 9.51e-01
RHOV GTPase cycle 37 8.49e-01 1.80e-02 9.09e-01
Gene Silencing by RNA 98 7.59e-01 1.79e-02 8.64e-01
Peptide ligand-binding receptors 113 7.44e-01 1.78e-02 8.54e-01
L1CAM interactions 93 7.67e-01 1.77e-02 8.67e-01
Pre-NOTCH Expression and Processing 71 7.97e-01 -1.77e-02 8.82e-01
Ion channel transport 157 7.03e-01 1.76e-02 8.27e-01
Signalling to ERKs 33 8.63e-01 1.74e-02 9.18e-01
Signal regulatory protein family interactions 11 9.21e-01 1.73e-02 9.51e-01
G-protein mediated events 50 8.36e-01 -1.70e-02 8.99e-01
Downstream signaling of activated FGFR4 24 8.88e-01 1.66e-02 9.34e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 9.03e-01 1.66e-02 9.41e-01
RNA Polymerase I Promoter Clearance 72 8.17e-01 1.58e-02 8.93e-01
RNA Polymerase I Transcription 72 8.17e-01 1.58e-02 8.93e-01
GPCR ligand binding 285 6.48e-01 -1.57e-02 7.83e-01
CD209 (DC-SIGN) signaling 20 9.03e-01 -1.57e-02 9.41e-01
Extracellular matrix organization 263 6.62e-01 -1.56e-02 7.95e-01
Plasma lipoprotein remodeling 24 8.95e-01 -1.56e-02 9.38e-01
Assembly of the ORC complex at the origin of replication 31 8.81e-01 1.55e-02 9.30e-01
Xenobiotics 16 9.17e-01 1.51e-02 9.50e-01
Signaling by GPCR 500 5.79e-01 -1.45e-02 7.28e-01
Fcgamma receptor (FCGR) dependent phagocytosis 85 8.18e-01 1.44e-02 8.94e-01
Insulin receptor signalling cascade 50 8.63e-01 -1.41e-02 9.18e-01
Biosynthesis of DHA-derived SPMs 14 9.28e-01 1.39e-02 9.57e-01
Olfactory Signaling Pathway 24 9.07e-01 -1.38e-02 9.44e-01
RAC1 GTPase cycle 178 7.51e-01 1.38e-02 8.57e-01
G alpha (i) signalling events 207 7.37e-01 1.36e-02 8.50e-01
Assembly Of The HIV Virion 16 9.31e-01 1.24e-02 9.59e-01
PI-3K cascade:FGFR2 20 9.25e-01 1.22e-02 9.54e-01
MET activates RAP1 and RAC1 11 9.45e-01 -1.19e-02 9.69e-01
VxPx cargo-targeting to cilium 19 9.29e-01 -1.17e-02 9.57e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 9.10e-01 -1.17e-02 9.46e-01
Potassium Channels 86 8.52e-01 -1.16e-02 9.10e-01
GPCR downstream signalling 442 6.77e-01 -1.15e-02 8.09e-01
Free fatty acids regulate insulin secretion 10 9.50e-01 -1.15e-02 9.70e-01
Cardiac conduction 112 8.37e-01 -1.13e-02 8.99e-01
Degradation of cysteine and homocysteine 12 9.46e-01 -1.12e-02 9.69e-01
PI3K events in ERBB4 signaling 10 9.51e-01 -1.12e-02 9.70e-01
Ca-dependent events 34 9.11e-01 -1.11e-02 9.46e-01
IGF1R signaling cascade 49 8.95e-01 1.09e-02 9.38e-01
Formation of Fibrin Clot (Clotting Cascade) 27 9.24e-01 1.06e-02 9.53e-01
NF-kB is activated and signals survival 13 9.48e-01 1.05e-02 9.70e-01
NOTCH2 intracellular domain regulates transcription 12 9.51e-01 1.02e-02 9.70e-01
Phase I - Functionalization of compounds 82 8.74e-01 -1.01e-02 9.25e-01
Alpha-protein kinase 1 signaling pathway 11 9.54e-01 -9.99e-03 9.71e-01
TRAF6 mediated NF-kB activation 23 9.35e-01 9.75e-03 9.62e-01
Maturation of nucleoprotein 11 9.55e-01 -9.73e-03 9.71e-01
Phospholipid metabolism 193 8.20e-01 -9.50e-03 8.95e-01
CDC42 GTPase cycle 153 8.42e-01 -9.33e-03 9.04e-01
Activation of HOX genes during differentiation 82 8.87e-01 -9.05e-03 9.34e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 82 8.87e-01 -9.05e-03 9.34e-01
DNA Double Strand Break Response 52 9.11e-01 -8.98e-03 9.46e-01
IRS-related events triggered by IGF1R 48 9.16e-01 -8.80e-03 9.50e-01
Acyl chain remodelling of PG 12 9.58e-01 -8.72e-03 9.73e-01
Cell death signalling via NRAGE, NRIF and NADE 76 8.98e-01 8.53e-03 9.39e-01
Nuclear Receptor transcription pathway 48 9.21e-01 -8.25e-03 9.51e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 28 9.41e-01 -8.13e-03 9.65e-01
CaM pathway 32 9.37e-01 8.07e-03 9.62e-01
Calmodulin induced events 32 9.37e-01 8.07e-03 9.62e-01
mRNA 3’-end processing 56 9.17e-01 8.01e-03 9.51e-01
Keratinization 58 9.20e-01 -7.66e-03 9.51e-01
Rab regulation of trafficking 120 8.92e-01 7.17e-03 9.37e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 9.69e-01 -6.70e-03 9.83e-01
Cleavage of the damaged purine 29 9.50e-01 6.69e-03 9.70e-01
Depurination 29 9.50e-01 6.69e-03 9.70e-01
Recognition and association of DNA glycosylase with site containing an affected purine 29 9.50e-01 6.69e-03 9.70e-01
TP53 Regulates Transcription of Cell Death Genes 43 9.41e-01 6.47e-03 9.65e-01
Downstream signaling of activated FGFR3 23 9.58e-01 6.32e-03 9.73e-01
Signaling by NTRKs 133 9.03e-01 -6.13e-03 9.41e-01
PRC2 methylates histones and DNA 35 9.54e-01 5.65e-03 9.71e-01
Cellular Senescence 153 9.12e-01 -5.15e-03 9.47e-01
Meiotic synapsis 50 9.55e-01 -4.56e-03 9.71e-01
Mitochondrial calcium ion transport 22 9.73e-01 4.21e-03 9.85e-01
Neuronal System 342 8.99e-01 -3.99e-03 9.39e-01
Acetylcholine binding and downstream events 11 9.84e-01 -3.54e-03 9.91e-01
Postsynaptic nicotinic acetylcholine receptors 11 9.84e-01 -3.54e-03 9.91e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 39 9.71e-01 -3.42e-03 9.84e-01
Cell recruitment (pro-inflammatory response) 23 9.78e-01 3.39e-03 9.87e-01
Purinergic signaling in leishmaniasis infection 23 9.78e-01 3.39e-03 9.87e-01
Gene expression (Transcription) 1398 8.65e-01 -2.69e-03 9.19e-01
Acyl chain remodelling of PS 17 9.85e-01 -2.64e-03 9.91e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 50 9.75e-01 -2.56e-03 9.86e-01
Elevation of cytosolic Ca2+ levels 13 9.88e-01 2.32e-03 9.93e-01
Regulation of TP53 Activity through Methylation 19 9.86e-01 -2.32e-03 9.91e-01
G alpha (12/13) signalling events 77 9.79e-01 -1.76e-03 9.87e-01
Sensory Perception 184 9.73e-01 -1.45e-03 9.85e-01
Pre-NOTCH Transcription and Translation 55 9.86e-01 1.35e-03 9.91e-01
Activation of kainate receptors upon glutamate binding 28 9.90e-01 -1.33e-03 9.94e-01
Notch-HLH transcription pathway 28 9.91e-01 -1.29e-03 9.94e-01
Regulation of innate immune responses to cytosolic DNA 14 9.93e-01 -1.29e-03 9.96e-01
Platelet Adhesion to exposed collagen 11 9.94e-01 -1.23e-03 9.96e-01
CRMPs in Sema3A signaling 16 9.95e-01 -9.81e-04 9.96e-01
RNA Polymerase II Transcription 1262 9.74e-01 -5.39e-04 9.85e-01
Signaling by FGFR1 48 9.98e-01 -1.58e-04 9.99e-01
Downstream signaling of activated FGFR2 27 1.00e+00 6.12e-05 1.00e+00


Detailed Gene set reports



Unwinding of DNA

Unwinding of DNA
1427
set Unwinding of DNA
setSize 12
pANOVA 1.01e-05
s.dist 0.736
p.adjustANOVA 6.79e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
GINS2 12599
MCM2 12140
MCM4 12113
GINS4 11992
GINS1 11681
CDC45 11329
MCM3 11283
MCM5 10865
MCM8 10355
GINS3 10094
MCM6 9193
MCM7 -13907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GINS2 12599
MCM2 12140
MCM4 12113
GINS4 11992
GINS1 11681
CDC45 11329
MCM3 11283
MCM5 10865
MCM8 10355
GINS3 10094
MCM6 9193
MCM7 -13907


Leading Strand Synthesis

Leading Strand Synthesis
640
set Leading Strand Synthesis
setSize 14
pANOVA 2.89e-06
s.dist 0.722
p.adjustANOVA 2.17e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RFC4 12293
RFC5 12157
RFC3 11888
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
RFC2 10552
POLD4 10381
POLD2 10201
POLD1 7223
POLA1 5953
RFC1 5243
POLD3 -6136

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RFC4 12293
RFC5 12157
RFC3 11888
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
RFC2 10552
POLD4 10381
POLD2 10201
POLD1 7223
POLA1 5953
RFC1 5243
POLD3 -6136


Polymerase switching

Polymerase switching
893
set Polymerase switching
setSize 14
pANOVA 2.89e-06
s.dist 0.722
p.adjustANOVA 2.17e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RFC4 12293
RFC5 12157
RFC3 11888
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
RFC2 10552
POLD4 10381
POLD2 10201
POLD1 7223
POLA1 5953
RFC1 5243
POLD3 -6136

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RFC4 12293
RFC5 12157
RFC3 11888
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
RFC2 10552
POLD4 10381
POLD2 10201
POLD1 7223
POLA1 5953
RFC1 5243
POLD3 -6136


Response to metal ions

Response to metal ions
1102
set Response to metal ions
setSize 10
pANOVA 7.78e-05
s.dist 0.721
p.adjustANOVA 0.000452



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT2A 12726
MT1X 12642
CSRP1 11811
MT1A 11657
MT1E 11245
MT1M 8775
SNCB 8652
MT1F 5248
MTF1 4807
MT1G 1913

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT2A 12726
MT1X 12642
CSRP1 11811
MT1A 11657
MT1E 11245
MT1M 8775
SNCB 8652
MT1F 5248
MTF1 4807
MT1G 1913


G1/S-Specific Transcription

G1/S-Specific Transcription
458
set G1/S-Specific Transcription
setSize 29
pANOVA 1.35e-10
s.dist 0.689
p.adjustANOVA 1.79e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
RRM2 12689
DHFR 12674
CDK1 12520
TYMS 12399
TK1 12261
TFDP2 12250
CDT1 12021
CDC6 11743
ORC1 11656
TFDP1 11600
PCNA 11595
CDC45 11329
E2F6 10776
CDC25A 10302
E2F1 10289
FBXO5 10008
RBBP4 9908
RBL1 9200
LIN52 8996
LIN9 7328

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RRM2 12689
DHFR 12674
CDK1 12520
TYMS 12399
TK1 12261
TFDP2 12250
CDT1 12021
CDC6 11743
ORC1 11656
TFDP1 11600
PCNA 11595
CDC45 11329
E2F6 10776
CDC25A 10302
E2F1 10289
FBXO5 10008
RBBP4 9908
RBL1 9200
LIN52 8996
LIN9 7328
E2F4 7326
LIN54 6601
CCNA1 6154
CCNE1 5969
POLA1 5953
HDAC1 4759
E2F5 1156
RBL2 -1061
LIN37 -12099


Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
216
set Condensation of Prometaphase Chromosomes
setSize 11
pANOVA 7.92e-05
s.dist 0.687
p.adjustANOVA 0.000457



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCNB2 12588
CDK1 12520
NCAPG 12491
CCNB1 12183
NCAPD2 11991
SMC4 11970
NCAPH 11733
SMC2 8585
CSNK2A1 7686
CSNK2B 1532
CSNK2A2 -10004

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNB2 12588
CDK1 12520
NCAPG 12491
CCNB1 12183
NCAPD2 11991
SMC4 11970
NCAPH 11733
SMC2 8585
CSNK2A1 7686
CSNK2B 1532
CSNK2A2 -10004


Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
1345
set Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
setSize 10
pANOVA 0.000231
s.dist 0.672
p.adjustANOVA 0.00112



Top enriched genes

Top 20 genes
GeneID Gene Rank
DHFR 12674
HSP90AA1 12629
GCHFR 12481
CALM1 12384
GCH1 11018
SPR 10281
PTS 8026
PRKG2 5985
AKT1 -942
NOS3 -1756

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DHFR 12674
HSP90AA1 12629
GCHFR 12481
CALM1 12384
GCH1 11018
SPR 10281
PTS 8026
PRKG2 5985
AKT1 -942
NOS3 -1756


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
423
set Formation of ATP by chemiosmotic coupling
setSize 18
pANOVA 9.15e-07
s.dist 0.668
p.adjustANOVA 7.48e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5MC1 12573
ATP5MC3 11518
ATP5PB 11353
ATP5PF 11264
ATP5F1E 11110
DMAC2L 10638
ATP5MG 10628
ATP5F1A 9986
ATP5F1B 9845
ATP5F1C 9306
ATP5MC2 8959
ATP5PD 8937
ATP5PO 7206
ATP5F1D 5870
ATP5MF 4075
ATP5ME 2212
MT-ATP8 2186
MT-ATP6 266

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MC1 12573
ATP5MC3 11518
ATP5PB 11353
ATP5PF 11264
ATP5F1E 11110
DMAC2L 10638
ATP5MG 10628
ATP5F1A 9986
ATP5F1B 9845
ATP5F1C 9306
ATP5MC2 8959
ATP5PD 8937
ATP5PO 7206
ATP5F1D 5870
ATP5MF 4075
ATP5ME 2212
MT-ATP8 2186
MT-ATP6 266


SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs
1130
set SLBP independent Processing of Histone Pre-mRNAs
setSize 10
pANOVA 0.000322
s.dist 0.657
p.adjustANOVA 0.0015



Top enriched genes

Top 20 genes
GeneID Gene Rank
SNRPG 12404
NCBP2 12178
SNRPE 11802
SNRPB 10044
LSM10 9224
SNRPF 9080
NCBP1 8822
SNRPD3 7705
LSM11 3127
ZNF473 -3728

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SNRPG 12404
NCBP2 12178
SNRPE 11802
SNRPB 10044
LSM10 9224
SNRPF 9080
NCBP1 8822
SNRPD3 7705
LSM11 3127
ZNF473 -3728


SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1129
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 11
pANOVA 0.000169
s.dist 0.655
p.adjustANOVA 0.000875



Top enriched genes

Top 20 genes
GeneID Gene Rank
SNRPG 12404
NCBP2 12178
SNRPE 11802
SNRPB 10044
LSM10 9224
SNRPF 9080
NCBP1 8822
SLBP 7761
SNRPD3 7705
LSM11 3127
ZNF473 -3728

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SNRPG 12404
NCBP2 12178
SNRPE 11802
SNRPB 10044
LSM10 9224
SNRPF 9080
NCBP1 8822
SLBP 7761
SNRPD3 7705
LSM11 3127
ZNF473 -3728


DNA strand elongation

DNA strand elongation
260
set DNA strand elongation
setSize 32
pANOVA 1.49e-10
s.dist 0.654
p.adjustANOVA 1.97e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
GINS2 12599
RPA3 12466
RFC4 12293
RFC5 12157
MCM2 12140
MCM4 12113
FEN1 11996
GINS4 11992
RFC3 11888
GINS1 11681
POLA2 11680
PCNA 11595
PRIM1 11591
CDC45 11329
MCM3 11283
MCM5 10865
PRIM2 10724
RFC2 10552
POLD4 10381
MCM8 10355

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GINS2 12599
RPA3 12466
RFC4 12293
RFC5 12157
MCM2 12140
MCM4 12113
FEN1 11996
GINS4 11992
RFC3 11888
GINS1 11681
POLA2 11680
PCNA 11595
PRIM1 11591
CDC45 11329
MCM3 11283
MCM5 10865
PRIM2 10724
RFC2 10552
POLD4 10381
MCM8 10355
POLD2 10201
GINS3 10094
RPA2 9854
MCM6 9193
POLD1 7223
POLA1 5953
RFC1 5243
RPA1 3220
POLD3 -6136
LIG1 -6204
DNA2 -9757
MCM7 -13907


Translesion synthesis by REV1

Translesion synthesis by REV1
1397
set Translesion synthesis by REV1
setSize 16
pANOVA 9.42e-06
s.dist 0.64
p.adjustANOVA 6.4e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
RFC3 11888
PCNA 11595
RPS27A 11143
UBB 10939
RFC2 10552
RPA2 9854
REV3L 9600
MAD2L2 9403
UBC 7520
RFC1 5243
RPA1 3220
UBA52 -2054
REV1 -10553

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
RFC3 11888
PCNA 11595
RPS27A 11143
UBB 10939
RFC2 10552
RPA2 9854
REV3L 9600
MAD2L2 9403
UBC 7520
RFC1 5243
RPA1 3220
UBA52 -2054
REV1 -10553


Translesion synthesis by POLK

Translesion synthesis by POLK
1396
set Translesion synthesis by POLK
setSize 17
pANOVA 5.71e-06
s.dist 0.635
p.adjustANOVA 4.07e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
RFC3 11888
PCNA 11595
RPS27A 11143
UBB 10939
RFC2 10552
RPA2 9854
REV3L 9600
MAD2L2 9403
UBC 7520
POLK 6857
RFC1 5243
RPA1 3220
UBA52 -2054
REV1 -10553

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
RFC3 11888
PCNA 11595
RPS27A 11143
UBB 10939
RFC2 10552
RPA2 9854
REV3L 9600
MAD2L2 9403
UBC 7520
POLK 6857
RFC1 5243
RPA1 3220
UBA52 -2054
REV1 -10553


Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
422
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.000553
s.dist 0.631
p.adjustANOVA 0.00245



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCT3 10735
CCT6A 10398
CCT4 10231
CCT7 9978
ACTB 9571
CCT8 9247
CCT2 9045
TCP1 8988
CCT5 4037
CCT6B -5139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT3 10735
CCT6A 10398
CCT4 10231
CCT7 9978
ACTB 9571
CCT8 9247
CCT2 9045
TCP1 8988
CCT5 4037
CCT6B -5139


SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21
1118
set SCF(Skp2)-mediated degradation of p27/p21
setSize 60
pANOVA 4e-17
s.dist 0.627
p.adjustANOVA 2.2e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
CDKN1A 12076
PSME3 11980
CKS1B 11954
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP2 11715
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
CCND1 11428
CDK2 11366
RPS27A 11143
PSMB5 11025

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
CDKN1A 12076
PSME3 11980
CKS1B 11954
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP2 11715
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
CCND1 11428
CDK2 11366
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
CDKN1B 9662
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
CDK4 9010
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
CCNA2 7816
UBC 7520
PSMC2 7229
PSMD9 7167
CCNA1 6154
CCNE1 5969
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
CCNE2 2492
PSMD6 140
PSME1 -1500
UBA52 -2054
PSMD5 -8988
PSMB8 -9809
PTK6 -10078
PSMB9 -11036


The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint
1351
set The role of GTSE1 in G2/M progression after G2 checkpoint
setSize 58
pANOVA 4.32e-16
s.dist 0.617
p.adjustANOVA 1.9e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90AA1 12629
CCNB2 12588
CDK1 12520
PSMA5 12432
CCNB1 12183
PSMA6 12089
CDKN1A 12076
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
MAPRE1 11582
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90AA1 12629
CCNB2 12588
CDK1 12520
PSMA5 12432
CCNB1 12183
PSMA6 12089
CDKN1A 12076
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
MAPRE1 11582
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
GTSE1 9678
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
HSP90AB1 9283
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PLK1 8153
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
FKBPL 5080
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
TP53 -9081
PSMB8 -9809
PSMB9 -11036


Metabolism of cofactors

Metabolism of cofactors
686
set Metabolism of cofactors
setSize 19
pANOVA 3.58e-06
s.dist 0.614
p.adjustANOVA 2.65e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
DHFR 12674
HSP90AA1 12629
GCHFR 12481
CALM1 12384
COQ5 11277
GCH1 11018
COQ2 10825
SPR 10281
PDSS1 9980
COQ3 8274
PDSS2 8200
PTS 8026
COQ6 6298
PRKG2 5985
IDH1 4854
COQ9 2938
AKT1 -942
NOS3 -1756
COQ7 -3324

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DHFR 12674
HSP90AA1 12629
GCHFR 12481
CALM1 12384
COQ5 11277
GCH1 11018
COQ2 10825
SPR 10281
PDSS1 9980
COQ3 8274
PDSS2 8200
PTS 8026
COQ6 6298
PRKG2 5985
IDH1 4854
COQ9 2938
AKT1 -942
NOS3 -1756
COQ7 -3324


Regulation of PTEN mRNA translation

Regulation of PTEN mRNA translation
1050
set Regulation of PTEN mRNA translation
setSize 12
pANOVA 0.000244
s.dist -0.612
p.adjustANOVA 0.00117



Top enriched genes

Top 20 genes
GeneID Gene Rank
MOV10 -13419
TNRC6B -12976
TNRC6A -12667
PTEN -12299
AGO2 -12096
PTENP1 -11262
AGO4 -10917
AGO3 -9248
CNOT6L -9218
AGO1 -9002
TNRC6C -8274
VAPA 10675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MOV10 -13419
TNRC6B -12976
TNRC6A -12667
PTEN -12299
AGO2 -12096
PTENP1 -11262
AGO4 -10917
AGO3 -9248
CNOT6L -9218
AGO1 -9002
TNRC6C -8274
VAPA 10675


Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D
1424
set Ubiquitin-dependent degradation of Cyclin D
setSize 50
pANOVA 9.5e-14
s.dist 0.608
p.adjustANOVA 2.53e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
CCND1 11428
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
GSK3B 10766
PSMC3 10692
PSMC5 10666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
CCND1 11428
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
GSK3B 10766
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
CDK4 9010
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


Lagging Strand Synthesis

Lagging Strand Synthesis
636
set Lagging Strand Synthesis
setSize 20
pANOVA 2.88e-06
s.dist 0.604
p.adjustANOVA 2.17e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
FEN1 11996
RFC3 11888
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
RFC2 10552
POLD4 10381
POLD2 10201
RPA2 9854
POLD1 7223
POLA1 5953
RFC1 5243
RPA1 3220
POLD3 -6136
LIG1 -6204
DNA2 -9757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
FEN1 11996
RFC3 11888
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
RFC2 10552
POLD4 10381
POLD2 10201
RPA2 9854
POLD1 7223
POLA1 5953
RFC1 5243
RPA1 3220
POLD3 -6136
LIG1 -6204
DNA2 -9757


Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation
1066
set Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize 48
pANOVA 7.16e-13
s.dist 0.598
p.adjustANOVA 1.5e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PAK2 9865
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


Removal of the Flap Intermediate

Removal of the Flap Intermediate
1086
set Removal of the Flap Intermediate
setSize 14
pANOVA 0.000118
s.dist 0.594
p.adjustANOVA 0.000653



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA3 12466
FEN1 11996
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
POLD4 10381
POLD2 10201
RPA2 9854
POLD1 7223
POLA1 5953
RPA1 3220
POLD3 -6136
DNA2 -9757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA3 12466
FEN1 11996
POLA2 11680
PCNA 11595
PRIM1 11591
PRIM2 10724
POLD4 10381
POLD2 10201
RPA2 9854
POLD1 7223
POLA1 5953
RPA1 3220
POLD3 -6136
DNA2 -9757


Vpu mediated degradation of CD4

Vpu mediated degradation of CD4
1444
set Vpu mediated degradation of CD4
setSize 50
pANOVA 3.71e-13
s.dist 0.594
p.adjustANOVA 8.3e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
CD4 6771
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
BTRC 2663
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation
213
set Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize 11
pANOVA 0.000687
s.dist -0.591
p.adjustANOVA 0.00297



Top enriched genes

Top 20 genes
GeneID Gene Rank
MOV10 -13419
TNRC6B -12976
TNRC6A -12667
AGO2 -12096
PTENP1 -11262
AGO4 -10917
AGO3 -9248
CNOT6L -9218
AGO1 -9002
TNRC6C -8274
VAPA 10675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MOV10 -13419
TNRC6B -12976
TNRC6A -12667
AGO2 -12096
PTENP1 -11262
AGO4 -10917
AGO3 -9248
CNOT6L -9218
AGO1 -9002
TNRC6C -8274
VAPA 10675


Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling
771
set Negative regulation of NOTCH4 signaling
setSize 54
pANOVA 6.48e-14
s.dist 0.589
p.adjustANOVA 1.79e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
TACC3 11352
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
TACC3 11352
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
YWHAZ 9834
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
NOTCH4 7925
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
RBX1 -331
AKT1 -942
PSME1 -1500
UBA52 -2054
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036
FBXW7 -11989


Hh mutants are degraded by ERAD

Hh mutants are degraded by ERAD
539
set Hh mutants are degraded by ERAD
setSize 54
pANOVA 9.03e-14
s.dist 0.586
p.adjustANOVA 2.44e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
SHH 12686
PSMA5 12432
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SHH 12686
PSMA5 12432
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
SYVN1 -439
VCP -871
PSME1 -1500
DERL2 -1891
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1
1119
set SCF-beta-TrCP mediated degradation of Emi1
setSize 53
pANOVA 1.66e-13
s.dist 0.585
p.adjustANOVA 4.05e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
CDC20 11684
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
CDC20 11684
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
FBXO5 10008
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
BTRC 2663
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036
FZR1 -11835


FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
386
set FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
setSize 53
pANOVA 2.1e-13
s.dist 0.583
p.adjustANOVA 4.96e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
AURKA 12174
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
AURKA 12174
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
FBXL18 9268
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
RBX1 -331
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
FBXL7 -10389
PSMB9 -11036


HuR (ELAVL1) binds and stabilizes mRNA

HuR (ELAVL1) binds and stabilizes mRNA
543
set HuR (ELAVL1) binds and stabilizes mRNA
setSize 10
pANOVA 0.00156
s.dist 0.578
p.adjustANOVA 0.00611



Top enriched genes

Top 20 genes
GeneID Gene Rank
GPRC5A 12612
ANP32A 12121
PRKCA 10091
ELAVL1 10078
ENPP2 9957
PRKCD 9846
XPO1 5851
TNFSF13 1143
NUP214 -329
SET -1487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPRC5A 12612
ANP32A 12121
PRKCA 10091
ELAVL1 10078
ENPP2 9957
PRKCD 9846
XPO1 5851
TNFSF13 1143
NUP214 -329
SET -1487


Regulation of BACH1 activity

Regulation of BACH1 activity
1036
set Regulation of BACH1 activity
setSize 11
pANOVA 0.000975
s.dist 0.574
p.adjustANOVA 0.0041



Top enriched genes

Top 20 genes
GeneID Gene Rank
CUL1 12341
SKP2 11715
SKP1 11672
RPS27A 11143
BACH1 11022
UBB 10939
UBC 7520
MAFK 4822
RBX1 -331
UBA52 -2054
FBXL17 -2458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CUL1 12341
SKP2 11715
SKP1 11672
RPS27A 11143
BACH1 11022
UBB 10939
UBC 7520
MAFK 4822
RBX1 -331
UBA52 -2054
FBXL17 -2458


Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
1423
set Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize 50
pANOVA 2.48e-12
s.dist 0.572
p.adjustANOVA 4.45e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
CDC25A 10302
PSMA1 10273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
CDC25A 10302
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
CHEK1 6566
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
CHEK2 -10300
PSMB9 -11036


p53-Independent DNA Damage Response

p53-Independent DNA Damage Response
1473
set p53-Independent DNA Damage Response
setSize 50
pANOVA 2.48e-12
s.dist 0.572
p.adjustANOVA 4.45e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
CDC25A 10302
PSMA1 10273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
CDC25A 10302
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
CHEK1 6566
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
CHEK2 -10300
PSMB9 -11036


p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint
1474
set p53-Independent G1/S DNA damage checkpoint
setSize 50
pANOVA 2.48e-12
s.dist 0.572
p.adjustANOVA 4.45e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
CDC25A 10302
PSMA1 10273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
CDC25A 10302
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
CHEK1 6566
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
CHEK2 -10300
PSMB9 -11036


Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol
1294
set Synthesis of bile acids and bile salts via 27-hydroxycholesterol
setSize 13
pANOVA 0.000363
s.dist -0.571
p.adjustANOVA 0.00168



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKR1C3 -14455
HSD3B7 -13620
AKR1C1 -13255
CYP27A1 -12994
RXRA -12352
AKR1C2 -12236
NCOA1 -9240
NR1H4 -5408
NCOA2 -4776
CYP7B1 -4552
CYP8B1 -3420
PTGIS -3347
AKR1D1 -3092

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKR1C3 -14455
HSD3B7 -13620
AKR1C1 -13255
CYP27A1 -12994
RXRA -12352
AKR1C2 -12236
NCOA1 -9240
NR1H4 -5408
NCOA2 -4776
CYP7B1 -4552
CYP8B1 -3420
PTGIS -3347
AKR1D1 -3092


Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM
1200
set Signaling by FGFR2 IIIa TM
setSize 19
pANOVA 1.82e-05
s.dist 0.568
p.adjustANOVA 0.000118



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2L 12317
NCBP2 12178
POLR2K 11614
POLR2C 11159
POLR2G 10585
POLR2H 9951
GTF2F2 9803
FGFR2 9491
POLR2E 8987
POLR2B 8936
NCBP1 8822
FGF1 6074
GTF2F1 6038
POLR2D 3369
POLR2I 2877
POLR2F 2706
POLR2A 921
POLR2J -1668
FGF2 -3988

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2L 12317
NCBP2 12178
POLR2K 11614
POLR2C 11159
POLR2G 10585
POLR2H 9951
GTF2F2 9803
FGFR2 9491
POLR2E 8987
POLR2B 8936
NCBP1 8822
FGF1 6074
GTF2F1 6038
POLR2D 3369
POLR2I 2877
POLR2F 2706
POLR2A 921
POLR2J -1668
FGF2 -3988


Hedgehog ligand biogenesis

Hedgehog ligand biogenesis
532
set Hedgehog ligand biogenesis
setSize 63
pANOVA 7.41e-15
s.dist 0.566
p.adjustANOVA 2.45e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
SHH 12686
PSMA5 12432
P4HB 12402
NOTUM 12257
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
PSMB5 11025
PSMD13 10950

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SHH 12686
PSMA5 12432
P4HB 12402
NOTUM 12257
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
ADAM17 10197
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
GPC5 9226
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
DISP2 7403
PSMC2 7229
PSMD9 7167
HHAT 3962
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
DHH 660
PSMD6 140
SYVN1 -439
VCP -871
PSME1 -1500
DERL2 -1891
IHH -1989
UBA52 -2054
PSME4 -6905
SCUBE2 -7546
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
1371
set Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
setSize 16
pANOVA 8.85e-05
s.dist 0.566
p.adjustANOVA 0.000501



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYBL2 12626
CDK1 12520
TFDP2 12250
TFDP1 11600
E2F1 10289
RBBP4 9908
RBL1 9200
LIN52 8996
CCNA2 7816
LIN9 7328
E2F4 7326
LIN54 6601
HDAC1 4759
E2F5 1156
RBL2 -1061
LIN37 -12099

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYBL2 12626
CDK1 12520
TFDP2 12250
TFDP1 11600
E2F1 10289
RBBP4 9908
RBL1 9200
LIN52 8996
CCNA2 7816
LIN9 7328
E2F4 7326
LIN54 6601
HDAC1 4759
E2F5 1156
RBL2 -1061
LIN37 -12099


Purine salvage

Purine salvage
931
set Purine salvage
setSize 12
pANOVA 0.000696
s.dist 0.565
p.adjustANOVA 0.00299



Top enriched genes

Top 20 genes
GeneID Gene Rank
APRT 12430
HPRT1 12035
AMPD3 12028
DGUOK 11198
GMPR2 11196
ADK 10805
ADAL 10453
PNP 10254
GMPR 9152
DCK 7645
ADA -12093
AMPD2 -13284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APRT 12430
HPRT1 12035
AMPD3 12028
DGUOK 11198
GMPR2 11196
ADK 10805
ADAL 10453
PNP 10254
GMPR 9152
DCK 7645
ADA -12093
AMPD2 -13284


GLI3 is processed to GLI3R by the proteasome

GLI3 is processed to GLI3R by the proteasome
466
set GLI3 is processed to GLI3R by the proteasome
setSize 57
pANOVA 1.58e-13
s.dist 0.565
p.adjustANOVA 3.99e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
GSK3B 10766
PSMC3 10692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
GSK3B 10766
PSMC3 10692
PSMC5 10666
PSMA1 10273
PRKACA 10142
PRKACB 10089
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
BTRC 2663
SUFU 2472
PSMD6 140
RBX1 -331
PSME1 -1500
UBA52 -2054
GLI3 -4826
CSNK1A1 -6034
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G
1436
set Vif-mediated degradation of APOBEC3G
setSize 52
pANOVA 1.92e-12
s.dist 0.564
p.adjustANOVA 3.71e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOBEC3G 12721
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
ELOC 10337

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOBEC3G 12721
PSMA5 12432
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
ELOC 10337
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
CUL5 3157
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
RBX1 -331
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036
ELOB -11356


Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
438
set Formation of tubulin folding intermediates by CCT/TriC
setSize 23
pANOVA 2.97e-06
s.dist 0.563
p.adjustANOVA 2.22e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB4A 12547
TUBA1B 12444
TUBA1C 12233
TUBB4B 12200
TUBB2A 11257
TUBB2B 11043
CCT3 10735
TUBB3 10556
TUBB6 10549
TUBAL3 10512
CCT6A 10398
CCT4 10231
CCT7 9978
TUBA1A 9909
CCT8 9247
CCT2 9045
TCP1 8988
CCT5 4037
TUBB1 634
TUBA3D -2667

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB4A 12547
TUBA1B 12444
TUBA1C 12233
TUBB4B 12200
TUBB2A 11257
TUBB2B 11043
CCT3 10735
TUBB3 10556
TUBB6 10549
TUBAL3 10512
CCT6A 10398
CCT4 10231
CCT7 9978
TUBA1A 9909
CCT8 9247
CCT2 9045
TCP1 8988
CCT5 4037
TUBB1 634
TUBA3D -2667
CCT6B -5139
TUBA8 -8748
TUBA4A -14060


Hh mutants abrogate ligand secretion

Hh mutants abrogate ligand secretion
538
set Hh mutants abrogate ligand secretion
setSize 57
pANOVA 2.06e-13
s.dist 0.562
p.adjustANOVA 4.94e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
SHH 12686
PSMA5 12432
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SHH 12686
PSMA5 12432
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
HHAT 3962
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
DHH 660
PSMD6 140
SYVN1 -439
VCP -871
PSME1 -1500
DERL2 -1891
IHH -1989
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036


Defective CFTR causes cystic fibrosis

Defective CFTR causes cystic fibrosis
273
set Defective CFTR causes cystic fibrosis
setSize 58
pANOVA 1.36e-13
s.dist 0.561
p.adjustANOVA 3.48e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
DERL1 11116
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
OS9 12176
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
SEL1L 11387
ERLEC1 11203
RPS27A 11143
DERL1 11116
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
ERLIN1 9281
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
RNF5 7917
UBC 7520
PSMC2 7229
PSMD9 7167
DERL3 5331
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
VCP -871
PSME1 -1500
DERL2 -1891
UBA52 -2054
RNF185 -3011
PSME4 -6905
PSMD5 -8988
ERLIN2 -9528
PSMB8 -9809
PSMB9 -11036


Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
188
set Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize 13
pANOVA 0.000462
s.dist 0.561
p.adjustANOVA 0.00208



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDK1 12520
YWHAQ 12361
CCNB1 12183
CDC25C 11793
YWHAB 10175
YWHAZ 9834
YWHAG 9039
YWHAH 8974
YWHAE 8402
SFN 8046
CHEK1 6566
CHEK2 -10300
WEE1 -11751

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDK1 12520
YWHAQ 12361
CCNB1 12183
CDC25C 11793
YWHAB 10175
YWHAZ 9834
YWHAG 9039
YWHAH 8974
YWHAE 8402
SFN 8046
CHEK1 6566
CHEK2 -10300
WEE1 -11751


Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER
478
set Gap-filling DNA repair synthesis and ligation in GG-NER
setSize 25
pANOVA 1.22e-06
s.dist 0.56
p.adjustANOVA 9.83e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
RFC3 11888
POLE2 11628
PCNA 11595
POLE3 11495
RPS27A 11143
UBB 10939
RFC2 10552
POLD4 10381
POLD2 10201
POLE4 10120
RPA2 9854
UBC 7520
POLD1 7223
POLK 6857
RFC1 5243
LIG3 4937
RPA1 3220

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
RFC3 11888
POLE2 11628
PCNA 11595
POLE3 11495
RPS27A 11143
UBB 10939
RFC2 10552
POLD4 10381
POLD2 10201
POLE4 10120
RPA2 9854
UBC 7520
POLD1 7223
POLK 6857
RFC1 5243
LIG3 4937
RPA1 3220
POLE 853
UBA52 -2054
POLD3 -6136
LIG1 -6204
XRCC1 -9471


PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair
825
set PCNA-Dependent Long Patch Base Excision Repair
setSize 21
pANOVA 8.81e-06
s.dist 0.56
p.adjustANOVA 6.02e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
FEN1 11996
RFC3 11888
POLE2 11628
PCNA 11595
POLE3 11495
RFC2 10552
POLD4 10381
POLD2 10201
POLE4 10120
RPA2 9854
POLD1 7223
RFC1 5243
RPA1 3220
APEX1 2828
POLE 853
POLD3 -6136
LIG1 -6204

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA3 12466
RFC4 12293
RFC5 12157
FEN1 11996
RFC3 11888
POLE2 11628
PCNA 11595
POLE3 11495
RFC2 10552
POLD4 10381
POLD2 10201
POLE4 10120
RPA2 9854
POLD1 7223
RFC1 5243
RPA1 3220
APEX1 2828
POLE 853
POLD3 -6136
LIG1 -6204
POLB -12017


NIK–>noncanonical NF-kB signaling

NIK–>noncanonical NF-kB signaling
745
set NIK–>noncanonical NF-kB signaling
setSize 57
pANOVA 2.86e-13
s.dist 0.559
p.adjustANOVA 6.54e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
PSMA6 12089
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
MAP3K14 10609
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
UBE2M 9270
PSMD7 9260
PSMA7 9241
FBXW11 8658
PSMD4 8653
PSMD1 8598
PSMD14 8452
CHUK 8379
PSMA4 8117
PSMD2 7977
UBA3 7789
UBC 7520
PSMC2 7229
PSMD9 7167
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
BTRC 2663
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
PSMB9 -11036
NFKB2 -13541
RELB -13570


NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
752
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 11
pANOVA 0.00134
s.dist 0.559
p.adjustANOVA 0.00537



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADAM10 12378
APH1B 11194
APH1A 10641
PSENEN 9981
YWHAZ 9834
NCSTN 8328
NOTCH4 7925
PSEN1 7309
PSEN2 5253
DLL4 5176
JAG1 -14025

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADAM10 12378
APH1B 11194
APH1A 10641
PSENEN 9981
YWHAZ 9834
NCSTN 8328
NOTCH4 7925
PSEN1 7309
PSEN2 5253
DLL4 5176
JAG1 -14025


MASTL Facilitates Mitotic Progression

MASTL Facilitates Mitotic Progression
662
set MASTL Facilitates Mitotic Progression
setSize 10
pANOVA 0.00225
s.dist 0.558
p.adjustANOVA 0.0084



Top enriched genes

Top 20 genes
GeneID Gene Rank
ENSA 12558
CDK1 12520
ARPP19 12276
CCNB1 12183
PPP2CA 12020
MASTL 11508
PPP2R1B 6872
PPP2R2D 6439
PPP2R1A -7177
PPP2CB -12032

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ENSA 12558
CDK1 12520
ARPP19 12276
CCNB1 12183
PPP2CA 12020
MASTL 11508
PPP2R1B 6872
PPP2R2D 6439
PPP2R1A -7177
PPP2CB -12032


Orc1 removal from chromatin

Orc1 removal from chromatin
818
set Orc1 removal from chromatin
setSize 69
pANOVA 1.12e-15
s.dist 0.557
p.adjustANOVA 4.64e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
MCM2 12140
MCM4 12113
PSMA6 12089
CDT1 12021
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
CDC6 11743
PSMD3 11738
PSMB3 11727
SKP2 11715
SKP1 11672
ORC1 11656
PSMC1 11554
PSMD11 11493
PSMB2 11467
CDK2 11366

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
CUL1 12341
MCM2 12140
MCM4 12113
PSMA6 12089
CDT1 12021
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
CDC6 11743
PSMD3 11738
PSMB3 11727
SKP2 11715
SKP1 11672
ORC1 11656
PSMC1 11554
PSMD11 11493
PSMB2 11467
CDK2 11366
MCM3 11283
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
MCM5 10865
PSMD10 10775
PSMC3 10692
PSMC5 10666
MCM8 10355
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
MCM6 9193
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
CCNA2 7816
UBC 7520
PSMC2 7229
PSMD9 7167
ORC3 6795
CCNA1 6154
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
ORC4 2326
PSMD6 140
RBX1 -331
PSME1 -1500
UBA52 -2054
PSME4 -6905
PSMD5 -8988
PSMB8 -9809
ORC6 -10133
ORC5 -10855
PSMB9 -11036
ORC2 -12965
MCM7 -13907


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.9          
##  [49] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       rlang_1.0.2           
##  [55] later_1.3.0            AnnotationDbi_1.54.1   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.0            cachem_1.0.6          
##  [61] cli_3.2.0              generics_0.1.2         RSQLite_2.2.10        
##  [64] broom_0.7.12           evaluate_0.15          fastmap_1.1.0         
##  [67] yaml_2.3.5             knitr_1.37             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.32.0       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.0        
##  [76] rstudioapi_0.13        png_0.1-7              reprex_2.0.1          
##  [79] geneplotter_1.70.0     bslib_0.3.1            stringi_1.7.6         
##  [82] highr_0.9              desc_1.4.1             lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.3.8            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] assertthat_0.2.1       rprojroot_2.0.2        withr_2.5.0           
## [100] GenomeInfoDbData_1.2.6 hms_1.1.1              grid_4.2.0            
## [103] rmarkdown_2.13         shiny_1.7.1            lubridate_1.8.0

END of report